                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Hohn, Michael J.
       Liu, Zhong
       Saunders, Jason
 
<120>  MODIFIED APOL1 POLYPEPTIDES

<130>  23351

<150>  US 61/727,443
<151>  2012-11-16

<150>  US 61/773,015
<151>  2013-03-05

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1122
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcggaag aagctggcgc gcgtgttcag caaaatgtcc cgtcgggtac cgatacgggt       60

gacccgcaga gcaaaccgct gggtgattgg gcagcaggta ccatggaccc ggaaagctct      120

atcttcatcg aagatgccat caaatacttc aaagaaaaag tgtctacgca aaacctgctg      180

ctgctgctga ccgacaatga agcctggaac ggctttgttg cagctgcgga actgccgcgt      240

aatgaagcag atgaactgcg caaagccctg gacaacctgg cacgtcagat gatcatgaaa      300

gataaaaact ggcatgacaa gggtcagcaa taccgtaact ggtttctgaa agaattcccg      360

cgcctgaaaa gcaaactgga agataatatt cgtcgcctgc gtgcactggc agacggtgtt      420

cagaaagtcc acaaaggtac cacgatcgcg aacgtggtta gcggctctct gagtattagt      480

tccggtatcc tgaccctggt gggcatgggt ctggcaccgt tcaccgaagg cggttccctg      540

gttctgctgg aaccgggcat ggaactgggt attacggccg cactgaccgg cattacgtca      600

tcgaccatcg attatggtaa aaaatggtgg acccaggctc aagcgcatga tctggtcatt      660

aaaagtctgg acaaactgaa agaagtgaaa gaatttctgg gcgaaaatat ctctaacttc      720

ctgagtctgg ctggtaatac gtaccagctg acccgcggca ttggtaaaga tatccgtgca      780

ctgcgtcgcg cccgcgcaaa cctgcaaagc gttccgcacg cttccgcgtc acgtccgcgc      840

gtcacggaac cgatttcggc agaaagcggc gaacaggtgg aacgtgttaa tgaaccgtcc      900

atcctggaaa tgtcacgcgg tgtgaaactg accgatgtcg cgcctgtgag ctttttcctg      960

gtgctggacg tcgtgtatct ggtttacgaa tctaaacatc tgcacgaagg tgctaaaagt     1020

gaaaccgcgg aagaactgaa aaaagttgcc caggaactgg aagaaaaact gaacatcctg     1080

aacaacaact acaaaatcct gcaggcagat caagaactgt ga                        1122


<210>  2
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Glu Ala Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly 
1               5                   10                  15      


Thr Asp Thr Gly Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala 
            20                  25                  30          


Gly Thr Met Asp Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys 
        35                  40                  45              


Tyr Phe Lys Glu Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr 
    50                  55                  60                  


Asp Asn Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg 
65                  70                  75                  80  


Asn Glu Ala Asp Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln 
                85                  90                  95      


Met Ile Met Lys Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg 
            100                 105                 110         


Asn Trp Phe Leu Lys Glu Phe Pro Arg Leu Lys Ser Lys Leu Glu Asp 
        115                 120                 125             


Asn Ile Arg Arg Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His 
    130                 135                 140                 


Lys Gly Thr Thr Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser 
145                 150                 155                 160 


Ser Gly Ile Leu Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu 
                165                 170                 175     


Gly Gly Ser Leu Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr 
            180                 185                 190         


Ala Ala Leu Thr Gly Ile Thr Ser Ser Thr Ile Asp Tyr Gly Lys Lys 
        195                 200                 205             


Trp Trp Thr Gln Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp 
    210                 215                 220                 


Lys Leu Lys Glu Val Lys Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe 
225                 230                 235                 240 


Leu Ser Leu Ala Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys 
                245                 250                 255     


Asp Ile Arg Ala Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro 
            260                 265                 270         


His Ala Ser Ala Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu 
        275                 280                 285             


Ser Gly Glu Gln Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met 
    290                 295                 300                 


Ser Arg Gly Val Lys Leu Thr Asp Val Ala Pro Val Ser Phe Phe Leu 
305                 310                 315                 320 


Val Leu Asp Val Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu 
                325                 330                 335     


Gly Ala Lys Ser Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu 
            340                 345                 350         


Leu Glu Glu Lys Leu Asn Ile Leu Asn Asn Asn Tyr Lys Ile Leu Gln 
        355                 360                 365             


Ala Asp Gln Glu Leu 
    370             


<210>  3
<211>  1146
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcggaag aagctggcgc gcgtgttcag caaaatgtcc cgtcgggtac cgatacgggt       60

gacccgcaga gcaaaccgct gggtgattgg gcagcaggta ccatggaccc ggaaagctct      120

atcttcatcg aagatgccat caaatacttc aaagaaaaag tgtctacgca aaacctgctg      180

ctgctgctga ccgacaatga agcctggaac ggctttgttg cagctgcgga actgccgcgt      240

aatgaagcag atgaactgcg caaagccctg gacaacctgg cacgtcagat gatcatgaaa      300

gataaaaact ggcatgacaa gggtcagcaa taccgtaact ggtttctgaa agaattcccg      360

cgcctgaaaa gcaaactgga agataatatt cgtcgcctgc gtgcactggc agacggtgtt      420

cagaaagtcc acaaaggtac cacgatcgcg aacgtggtta gcggctctct gagtattagt      480

tccggtatcc tgaccctggt gggcatgggt ctggcaccgt tcaccgaagg cggttccctg      540

gttctgctgg aaccgggcat ggaactgggt attacggccg cactgaccgg cattacgtca      600

tcgaccatcg attatggtaa aaaatggtgg acccaggctc aagcgcatga tctggtcatt      660

aaaagtctgg acaaactgaa agaagtgaaa gaatttctgg gcgaaaatat ctctaacttc      720

ctgagtctgg ctggtaatac gtaccagctg acccgcggca ttggtaaaga tatccgtgca      780

ctgcgtcgcg cccgcgcaaa cctgcaaagc gttccgcacg cttccgcgtc acgtccgcgc      840

gtcacggaac cgatttcggc agaaagcggc gaacaggtgg aacgtgttaa tgaaccgtcc      900

atcctggaaa tgtcacgcgg tgtgaaactg accgatgtcg cgcctgtgag ctttttcctg      960

gtgctggacg tcgtgtatct ggtttacgaa tctaaacatc tgcacgaagg tgctaaaagt     1020

gaaaccgcgg aagaactgaa aaaagttgcc caggaactgg aagaaaaact gaacatcctg     1080

aacaacaact acaaaatcct gcaggcagat caagaactgc tcgagcacca ccaccaccac     1140

cactga                                                                1146


<210>  4
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Glu Ala Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly 
1               5                   10                  15      


Thr Asp Thr Gly Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala 
            20                  25                  30          


Gly Thr Met Asp Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys 
        35                  40                  45              


Tyr Phe Lys Glu Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr 
    50                  55                  60                  


Asp Asn Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg 
65                  70                  75                  80  


Asn Glu Ala Asp Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln 
                85                  90                  95      


Met Ile Met Lys Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg 
            100                 105                 110         


Asn Trp Phe Leu Lys Glu Phe Pro Arg Leu Lys Ser Lys Leu Glu Asp 
        115                 120                 125             


Asn Ile Arg Arg Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His 
    130                 135                 140                 


Lys Gly Thr Thr Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser 
145                 150                 155                 160 


Ser Gly Ile Leu Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu 
                165                 170                 175     


Gly Gly Ser Leu Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr 
            180                 185                 190         


Ala Ala Leu Thr Gly Ile Thr Ser Ser Thr Ile Asp Tyr Gly Lys Lys 
        195                 200                 205             


Trp Trp Thr Gln Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp 
    210                 215                 220                 


Lys Leu Lys Glu Val Lys Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe 
225                 230                 235                 240 


Leu Ser Leu Ala Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys 
                245                 250                 255     


Asp Ile Arg Ala Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro 
            260                 265                 270         


His Ala Ser Ala Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu 
        275                 280                 285             


Ser Gly Glu Gln Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met 
    290                 295                 300                 


Ser Arg Gly Val Lys Leu Thr Asp Val Ala Pro Val Ser Phe Phe Leu 
305                 310                 315                 320 


Val Leu Asp Val Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu 
                325                 330                 335     


Gly Ala Lys Ser Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu 
            340                 345                 350         


Leu Glu Glu Lys Leu Asn Ile Leu Asn Asn Asn Tyr Lys Ile Leu Gln 
        355                 360                 365             


Ala Asp Gln Glu Leu Leu Glu His His His His His His 
    370                 375                 380     


<210>  5
<211>  1137
<212>  DNA
<213>  Homo sapiens

<400>  5
atggctggcg cgcgtgttca gcaaaatgtc ccgtcgggta ccgatacggg tgacccgcag       60

agcaaaccgc tgggtgattg ggcagcaggt accatggacc cggaaagctc tatcttcatc      120

gaagatgcca tcaaatactt caaagaaaaa gtgtctacgc aaaacctgct gctgctgctg      180

accgacaatg aagcctggaa cggctttgtt gcagctgcgg aactgccgcg taatgaagca      240

gatgaactgc gcaaagccct ggacaacctg gcacgtcaga tgatcatgaa agataaaaac      300

tggcatgaca agggtcagca ataccgtaac tggtttctga aagaattccc gcgcctgaaa      360

agcaaactgg aagataatat tcgtcgcctg cgtgcactgg cagacggtgt tcagaaagtc      420

cacaaaggta ccacgatcgc gaacgtggtt agcggctctc tgagtattag ttccggtatc      480

ctgaccctgg tgggcatggg tctggcaccg ttcaccgaag gcggttccct ggttctgctg      540

gaaccgggca tggaactggg tattacggcc gcactgaccg gcattacgtc atcgaccatc      600

gattatggta aaaaatggtg gacccaggct caagcgcatg atctggtcat taaaagtctg      660

gacaaactga aagaagtgaa agaatttctg ggcgaaaata tctctaactt cctgagtctg      720

gctggtaata cgtaccagct gacccgcggc attggtaaag atatccgtgc actgcgtcgc      780

gcccgcgcaa acctgcaaag cgttccgcac gcttccgcgt cacgtccgcg cgtcacggaa      840

ccgatttcgg cagaaagcgg cgaacaggtg gaacgtgtta atgaaccgtc catcctggaa      900

atgtcacgcg gtgtgaaact gaccgatgtc gcgcctgtga gctttttcct ggtgctggac      960

gtcgtgtatc tggtttacga atctaaacat ctgcacgaag gtgctaaaag tgaaaccgcg     1020

gaagaactga aaaaagttgc ccaggaactg gaagaaaaac tgaacatcct gaacaacaac     1080

tacaaaatcc tgcaggcaga tcaagaactg ctcgagcacc accaccacca ccactga        1137


<210>  6
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr 
1               5                   10                  15      


Gly Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met 
            20                  25                  30          


Asp Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys 
        35                  40                  45              


Glu Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu 
    50                  55                  60                  


Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala 
65                  70                  75                  80  


Asp Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met 
                85                  90                  95      


Lys Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe 
            100                 105                 110         


Leu Lys Glu Phe Pro Arg Leu Lys Ser Lys Leu Glu Asp Asn Ile Arg 
        115                 120                 125             


Arg Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr 
    130                 135                 140                 


Thr Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile 
145                 150                 155                 160 


Leu Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser 
                165                 170                 175     


Leu Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu 
            180                 185                 190         


Thr Gly Ile Thr Ser Ser Thr Ile Asp Tyr Gly Lys Lys Trp Trp Thr 
        195                 200                 205             


Gln Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys 
    210                 215                 220                 


Glu Val Lys Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu 
225                 230                 235                 240 


Ala Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg 
                245                 250                 255     


Ala Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser 
            260                 265                 270         


Ala Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu 
        275                 280                 285             


Gln Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly 
    290                 295                 300                 


Val Lys Leu Thr Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp 
305                 310                 315                 320 


Val Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
                325                 330                 335     


Ser Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu 
            340                 345                 350         


Lys Leu Asn Ile Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln 
        355                 360                 365             


Glu Leu Leu Glu His His His His His His 
    370                 375             


<210>  7
<211>  1134
<212>  DNA
<213>  Homo sapiens

<400>  7
atgggcgcgc gtgttcagca aaatgtcccg tcgggtaccg atacgggtga cccgcagagc       60

aaaccgctgg gtgattgggc agcaggtacc atggacccgg aaagctctat cttcatcgaa      120

gatgccatca aatacttcaa agaaaaagtg tctacgcaaa acctgctgct gctgctgacc      180

gacaatgaag cctggaacgg ctttgttgca gctgcggaac tgccgcgtaa tgaagcagat      240

gaactgcgca aagccctgga caacctggca cgtcagatga tcatgaaaga taaaaactgg      300

catgacaagg gtcagcaata ccgtaactgg tttctgaaag aattcccgcg cctgaaaagc      360

aaactggaag ataatattcg tcgcctgcgt gcactggcag acggtgttca gaaagtccac      420

aaaggtacca cgatcgcgaa cgtggttagc ggctctctga gtattagttc cggtatcctg      480

accctggtgg gcatgggtct ggcaccgttc accgaaggcg gttccctggt tctgctggaa      540

ccgggcatgg aactgggtat tacggccgca ctgaccggca ttacgtcatc gaccatcgat      600

tatggtaaaa aatggtggac ccaggctcaa gcgcatgatc tggtcattaa aagtctggac      660

aaactgaaag aagtgaaaga atttctgggc gaaaatatct ctaacttcct gagtctggct      720

ggtaatacgt accagctgac ccgcggcatt ggtaaagata tccgtgcact gcgtcgcgcc      780

cgcgcaaacc tgcaaagcgt tccgcacgct tccgcgtcac gtccgcgcgt cacggaaccg      840

atttcggcag aaagcggcga acaggtggaa cgtgttaatg aaccgtccat cctggaaatg      900

tcacgcggtg tgaaactgac cgatgtcgcg cctgtgagct ttttcctggt gctggacgtc      960

gtgtatctgg tttacgaatc taaacatctg cacgaaggtg ctaaaagtga aaccgcggaa     1020

gaactgaaaa aagttgccca ggaactggaa gaaaaactga acatcctgaa caacaactac     1080

aaaatcctgc aggcagatca agaactgctc gagcaccacc accaccacca ctga           1134


<210>  8
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly 
1               5                   10                  15      


Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp 
            20                  25                  30          


Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu 
        35                  40                  45              


Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala 
    50                  55                  60                  


Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp 
65                  70                  75                  80  


Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys 
                85                  90                  95      


Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu 
            100                 105                 110         


Lys Glu Phe Pro Arg Leu Lys Ser Lys Leu Glu Asp Asn Ile Arg Arg 
        115                 120                 125             


Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr 
    130                 135                 140                 


Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu 
145                 150                 155                 160 


Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu 
                165                 170                 175     


Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr 
            180                 185                 190         


Gly Ile Thr Ser Ser Thr Ile Asp Tyr Gly Lys Lys Trp Trp Thr Gln 
        195                 200                 205             


Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu 
    210                 215                 220                 


Val Lys Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala 
225                 230                 235                 240 


Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala 
                245                 250                 255     


Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala 
            260                 265                 270         


Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln 
        275                 280                 285             


Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val 
    290                 295                 300                 


Lys Leu Thr Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val 
305                 310                 315                 320 


Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser 
                325                 330                 335     


Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys 
            340                 345                 350         


Leu Asn Ile Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu 
        355                 360                 365             


Leu Leu Glu His His His His His His 
    370                 375         


<210>  9
<211>  1119
<212>  DNA
<213>  Homo sapiens

<400>  9
atggaagaag ctggcgcgcg tgttcagcaa aatgtcccgt cgggtaccga tacgggtgac       60

ccgcagagca aaccgctggg tgattgggca gcaggtacca tggacccgga aagctctatc      120

ttcatcgaag atgccatcaa atacttcaaa gaaaaagtgt ctacgcaaaa cctgctgctg      180

ctgctgaccg acaatgaagc ctggaacggc tttgttgcag ctgcggaact gccgcgtaat      240

gaagcagatg aactgcgcaa agccctggac aacctggcac gtcagatgat catgaaagat      300

aaaaactggc atgacaaggg tcagcaatac cgtaactggt ttctgaaaga attcccgcgc      360

ctgaaaagca aactggaaga taatattcgt cgcctgcgtg cactggcaga cggtgttcag      420

aaagtccaca aaggtaccac gatcgcgaac gtggttagcg gctctctgag tattagttcc      480

ggtatcctga ccctggtggg catgggtctg gcaccgttca ccgaaggcgg ttccctggtt      540

ctgctggaac cgggcatgga actgggtatt acggccgcac tgaccggcat tacgtcatcg      600

accatcgatt atggtaaaaa atggtggacc caggctcaag cgcatgatct ggtcattaaa      660

agtctggaca aactgaaaga agtgaaagaa tttctgggcg aaaatatctc taacttcctg      720

agtctggctg gtaatacgta ccagctgacc cgcggcattg gtaaagatat ccgtgcactg      780

cgtcgcgccc gcgcaaacct gcaaagcgtt ccgcacgctt ccgcgtcacg tccgcgcgtc      840

acggaaccga tttcggcaga aagcggcgaa caggtggaac gtgttaatga accgtccatc      900

ctggaaatgt cacgcggtgt gaaactgacc gatgtcgcgc ctgtgagctt tttcctggtg      960

ctggacgtcg tgtatctggt ttacgaatct aaacatctgc acgaaggtgc taaaagtgaa     1020

accgcggaag aactgaaaaa agttgcccag gaactggaag aaaaactgaa catcctgaac     1080

aacaactaca aaatcctgca ggcagatcaa gaactgtga                            1119


<210>  10
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Glu Ala Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly Thr 
1               5                   10                  15      


Asp Thr Gly Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly 
            20                  25                  30          


Thr Met Asp Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr 
        35                  40                  45              


Phe Lys Glu Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp 
    50                  55                  60                  


Asn Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asn 
65                  70                  75                  80  


Glu Ala Asp Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln Met 
                85                  90                  95      


Ile Met Lys Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg Asn 
            100                 105                 110         


Trp Phe Leu Lys Glu Phe Pro Arg Leu Lys Ser Lys Leu Glu Asp Asn 
        115                 120                 125             


Ile Arg Arg Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His Lys 
    130                 135                 140                 


Gly Thr Thr Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser Ser 
145                 150                 155                 160 


Gly Ile Leu Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu Gly 
                165                 170                 175     


Gly Ser Leu Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr Ala 
            180                 185                 190         


Ala Leu Thr Gly Ile Thr Ser Ser Thr Ile Asp Tyr Gly Lys Lys Trp 
        195                 200                 205             


Trp Thr Gln Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp Lys 
    210                 215                 220                 


Leu Lys Glu Val Lys Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu 
225                 230                 235                 240 


Ser Leu Ala Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp 
                245                 250                 255     


Ile Arg Ala Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro His 
            260                 265                 270         


Ala Ser Ala Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu Ser 
        275                 280                 285             


Gly Glu Gln Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met Ser 
    290                 295                 300                 


Arg Gly Val Lys Leu Thr Asp Val Ala Pro Val Ser Phe Phe Leu Val 
305                 310                 315                 320 


Leu Asp Val Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu Gly 
                325                 330                 335     


Ala Lys Ser Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu Leu 
            340                 345                 350         


Glu Glu Lys Leu Asn Ile Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala 
        355                 360                 365             


Asp Gln Glu Leu 
    370         


<210>  11
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  11
atggaagaag ctggcgcgcg tgttcagcaa aatgtcccgt cgggtaccga tacgggtgac       60

ccgcagagca aaccgctggg tgattgggca gcaggtacca tggacccgga aagctctatc      120

ttcatcgaag atgccatcaa atacttcaaa gaaaaagtgt ctacgcaaaa cctgctgctg      180

ctgctgaccg acaatgaagc ctggaacggc tttgttgcag ctgcggaact gccgcgtaat      240

gaagcagatg aactgcgcaa agccctggac aacctggcac gtcagatgat catgaaagat      300

aaaaactggc atgacaaggg tcagcaatac cgtaactggt ttctgaaaga attcccgcgc      360

ctgaaaagca aactggaaga taatattcgt cgcctgcgtg cactggcaga cggtgttcag      420

aaagtccaca aaggtaccac gatcgcgaac gtggttagcg gctctctgag tattagttcc      480

ggtatcctga ccctggtggg catgggtctg gcaccgttca ccgaaggcgg ttccctggtt      540

ctgctggaac cgggcatgga actgggtatt acggccgcac tgaccggcat tacgtcatcg      600

accatcgatt atggtaaaaa atggtggacc caggctcaag cgcatgatct ggtcattaaa      660

agtctggaca aactgaaaga agtgaaagaa tttctgggcg aaaatatctc taacttcctg      720

agtctggctg gtaatacgta ccagctgacc cgcggcattg gtaaagatat ccgtgcactg      780

cgtcgcgccc gcgcaaacct gcaaagcgtt ccgcacgctt ccgcgtcacg tccgcgcgtc      840

acggaaccga tttcggcaga aagcggcgaa caggtggaac gtgttaatga accgtccatc      900

ctggaaatgt cacgcggtgt gaaactgacc gatgtcgcgc ctgtgagctt tttcctggtg      960

ctggacgtcg tgtatctggt ttacgaatct aaacatctgc acgaaggtgc taaaagtgaa     1020

accgcggaag aactgaaaaa agttgcccag gaactggaag aaaaactgaa catcctgaac     1080

aacaactaca aaatcctgca ggcagatcaa gaactgctcg agcaccacca ccaccaccac     1140

tga                                                                   1143


<210>  12
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Glu Ala Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly Thr 
1               5                   10                  15      


Asp Thr Gly Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly 
            20                  25                  30          


Thr Met Asp Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr 
        35                  40                  45              


Phe Lys Glu Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp 
    50                  55                  60                  


Asn Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asn 
65                  70                  75                  80  


Glu Ala Asp Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln Met 
                85                  90                  95      


Ile Met Lys Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg Asn 
            100                 105                 110         


Trp Phe Leu Lys Glu Phe Pro Arg Leu Lys Ser Lys Leu Glu Asp Asn 
        115                 120                 125             


Ile Arg Arg Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His Lys 
    130                 135                 140                 


Gly Thr Thr Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser Ser 
145                 150                 155                 160 


Gly Ile Leu Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu Gly 
                165                 170                 175     


Gly Ser Leu Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr Ala 
            180                 185                 190         


Ala Leu Thr Gly Ile Thr Ser Ser Thr Ile Asp Tyr Gly Lys Lys Trp 
        195                 200                 205             


Trp Thr Gln Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp Lys 
    210                 215                 220                 


Leu Lys Glu Val Lys Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu 
225                 230                 235                 240 


Ser Leu Ala Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp 
                245                 250                 255     


Ile Arg Ala Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro His 
            260                 265                 270         


Ala Ser Ala Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu Ser 
        275                 280                 285             


Gly Glu Gln Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met Ser 
    290                 295                 300                 


Arg Gly Val Lys Leu Thr Asp Val Ala Pro Val Ser Phe Phe Leu Val 
305                 310                 315                 320 


Leu Asp Val Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu Gly 
                325                 330                 335     


Ala Lys Ser Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu Leu 
            340                 345                 350         


Glu Glu Lys Leu Asn Ile Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala 
        355                 360                 365             


Asp Gln Glu Leu Leu Glu His His His His His His 
    370                 375                 380 


<210>  13
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala 
            20                  25          


<210>  14
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Glu Ala Gly Ala 
1               5   


