                         SEQUENCE LISTING

<110>  United Biomedical, Inc.
       Wang, Chang-Yi
 
<120>  Synthetic Peptide-Based Emergency Vaccine Against Foot And Mouth 
       Disease (FMD)

<130>  1004263.209WO

<140>  TBD
<141>  2012-11-15

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UBI Foot-and-mouth disease virus (FMDV) O Consensus sequence VP1 
       134-158, cyclized.

<400>  1

Cys Lys Tyr Gly Glu Asn Ala Val Thr Asn Val Arg Gly Asp Leu Gln 
1               5                   10                  15      


Val Leu Ala Gln Lys Ala Ala Arg Cys 
            20                  25  


<210>  2
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Foot-and-mouth disease virus (FMDV) O Consensus VP1 129-168, 
       (2570A), Peptides with both 134 and 158 AA positions substituted 
       by Cys and cyclized.

<400>  2

Val Tyr Asn Gly Asn Cys Lys Tyr Gly Glu Asn Ala Val Thr Asn Val 
1               5                   10                  15      


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala Arg Cys Leu Pro 
            20                  25                  30          


Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40      


<210>  3
<211>  41
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(41)
<223>  Foot-and-Mouth Disease Virus (FMDV) O Consensus VP1 129-168, 
       (2570A), Peptides with both 134 and 158 AA positions substituted 
       by Cys and cyclized.

<400>  3

Val Tyr Asn Gly Glu Cys Arg Tyr Ser Arg Asn Ala Val Pro Asn Val 
1               5                   10                  15      


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Val Ala Arg Cys Leu Pro 
            20                  25                  30          


Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40      


<210>  4
<211>  41
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(41)
<223>  UBI FMDV Taiwan 2956a VP1. Peptides with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  4

Val Tyr Asn Gly Ser Cys Lys Tyr Gly Asp Thr Ser Thr Asn Asn Val 
1               5                   10                  15      


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Glu Arg Cys Leu Pro 
            20                  25                  30          


Thr Ser Phe Asn Phe Gly Ala Ile Lys 
        35                  40      


<210>  5
<211>  41
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(41)
<223>  UBI FMDV  O O1K/O1BFS, VP1. Peptides with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  5

Val Tyr Asn Gly Glu Cys Arg Tyr Asn Arg Asn Ala Val Pro Asn Leu 
1               5                   10                  15      


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Val Ala Arg Thr Leu Pro 
            20                  25                  30          


Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40      


<210>  6
<211>  41
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(41)
<223>  UBI FMDV China (Gd/86) VP1. Peptides with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  6

Val Tyr Asn Gly Ser Cys Lys Tyr Ser Asp Ala Arg Val Ser Asn Val 
1               5                   10                  15      


Arg Gly Asp Leu Arg Val Leu Ala Gln Lys Ala Glu Arg Ala Leu Pro 
            20                  25                  30          


Thr Ser Ser Asn Tyr Gly Ala Ile Lys 
        35                  40      


<210>  7
<211>  41
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(41)
<223>  UBI FMDV O Swine/Cattle/O/MYA/7/02 VP1.  Peptides with both 134 
       and 158 AA positions substituted by Cys and cyclized.

<400>  7

Val Tyr Asn Gly Asn Cys Lys Tyr Ala Gly Gly Ser Leu Thr Asn Val 
1               5                   10                  15      


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala Arg Cys Leu Pro 
            20                  25                  30          


Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40      


<210>  8
<211>  41
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(41)
<223>  UBI FMDV O/Ozk/93, VP1. Peptides with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  8

Val Tyr Asn Gly Asn Cys Lys Tyr Ser Asp Arg Ala Val Ser Asn Val 
1               5                   10                  15      


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala Arg Cys Leu Pro 
            20                  25                  30          


Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40      


<210>  9
<211>  41
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  UBI Foot-and-Mouth Disease Virus (FMDV) O/A/58, VP1.  Peptides 
       with both 134 and 158 AA positions substituted by Cys and 
       cyclized.
<222>  (1)..(41)
<223>  UBI FMDV O/A/58, VP1.  Peptides with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  9

Val Tyr Asn Gly Asn Cys Lys Tyr Gly Val Gly Pro Val Thr Lys Val 
1               5                   10                  15      


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala Arg Cys Leu Pro 
            20                  25                  30          


Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40      


<210>  10
<211>  41
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(41)
<223>  UBI FMDV O/OZK/93, VP1.  Peptides with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  10

Val Tyr Asn Gly Asn Cys Lys Tyr Ser Asp Arg Pro Val Thr Lys Val 
1               5                   10                  15      


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala Arg Cys Leu Pro 
            20                  25                  30          


Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40      


<210>  11
<211>  41
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(41)
<223>  UBI FMDV O Lanzhou, VP1. Peptides with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  11

Val Tyr Asn Gly Ser Cys Lys Tyr Ser Asp Ala Arg Val Ser Asn Val 
1               5                   10                  15      


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Glu Arg Cys Leu Pro 
            20                  25                  30          


Ser Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40      


<210>  12
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UBI Foot-and-Mouth Disease Virus (FMDV) Asia 1 Consensus, VP1. 
       Peptides with both 134 and 158 AA positions substituted by Cys 
       and cyclized.

<400>  12

Val Tyr Asn Gly Lys Cys Thr Tyr Gly Glu Gln Pro Ser Arg Arg Gly 
1               5                   10                  15      


Asp Met Ala Ala Leu Ala Gln Arg Leu Ser Arg Cys Leu Pro Thr Ser 
            20                  25                  30          


Phe Asn Tyr Gly Ala Val Lys 
        35                  


<210>  13
<211>  39
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(39)
<223>  UBI FMDV Asia 1 Yunnan PRC, VP1. Peptides with both 134 and 158 
       AA positions substituted by Cys and cyclized.

<400>  13

Val Tyr Asn Gly Lys Cys Thr Tyr Gly Glu Glu Ser Thr Arg Arg Gly 
1               5                   10                  15      


Asp Phe Ala Ala Leu Ala Gln Arg Leu Ser Arg Cys Leu Pro Thr Ser 
            20                  25                  30          


Phe Asn Tyr Gly Ala Val Lys 
        35                  


<210>  14
<211>  39
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(39)
<223>  UBI FMDV Asia 1 KZC-2/10 PRC, VP1. Peptides with both 134 and 158
       AA positions substituted by Cys and cyclized.

<400>  14

Val Tyr Asn Gly Lys Cys Thr Tyr Gly Glu Thr Thr Ala Arg Arg Gly 
1               5                   10                  15      


Asp Thr Ala Ala Leu Ala Gln Arg Leu Ser Gly Cys Leu Pro Thr Ser 
            20                  25                  30          


Phe Asn Tyr Gly Ala Val Lys 
        35                  


<210>  15
<211>  39
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(39)
<223>  UBI FMDV Asia 1 JiangSu/China/2005, VP1. Peptides with both 134 
       and 158 AA positions substituted by Cys and cyclized.

<400>  15

Val Tyr Asn Gly Lys Cys Thr Tyr Gly Glu Glu Ser Ser Arg Arg Gly 
1               5                   10                  15      


Asp Leu Ala Ala Leu Ala Arg Arg Val Asn Asn Cys Leu Pro Thr Ser 
            20                  25                  30          


Phe Asn Tyr Gly Ala Val Lys 
        35                  


<210>  16
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UBI Foot-and-Mouth Disease Virus (FMDV) A consensus, VP1. 
       Peptides with both 134 and 158 AA positions substituted by Cys 
       and cyclized.


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  UBI FMDV A consensus, VP1. Peptides with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  16

Val Tyr Asn Gly Thr Cys Lys Tyr Thr Val Gly Gly Ser Gly Arg Arg 
1               5                   10                  15      


Gly Asp Leu Gly Ser Leu Ala Ala Arg Val Ala Lys Cys Leu Pro Ala 
            20                  25                  30          


Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40  


<210>  17
<211>  40
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  UBI FMDV A24 Cruzeiro California, VP1. Peptides with both 134 and
       158 AA positions substituted by Cys and cyclized.

<400>  17

Val Tyr Asn Gly Thr Ser Lys Tyr Ala Val Gly Gly Ser Gly Arg Arg 
1               5                   10                  15      


Gly Asp Met Gly Ser Leu Ala Ala Arg Val Val Lys Gln Leu Pro Ala 
            20                  25                  30          


Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40  


<210>  18
<211>  40
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  UBI FMDV A Gansu/China/60Y, VP1. Peptide with both 134 and 158 AA
       positions substituted by Cys and cyclized.

<400>  18

Val Tyr Asn Gly Thr Cys Gln Tyr Ser Thr Gly Asn Ala Gly Arg Arg 
1               5                   10                  15      


Gly Asp Leu Gly Ser Leu Ala Arg Val Ala Ala Gln Cys Leu Pro Ala 
            20                  25                  30          


Ser Phe Asn Phe Gly Ala Ile Arg 
        35                  40  


<210>  19
<211>  40
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  UBI FMDV A XinJiang/China/58Y, VP1. Peptides with both 134 and 
       158 AA positions substituted by Cys and cyclized.

<400>  19

Val Tyr Asn Gly Thr Cys Thr Tyr Ser Thr Gly Ser Ala Gly Arg Arg 
1               5                   10                  15      


Gly Asp Leu Gly Ser Leu Ala Ala Arg Val Ala Asn Cys Leu Pro Ala 
            20                  25                  30          


Ser Phe Asn Phe Gly Ala Ile Arg 
        35                  40  


<210>  20
<211>  40
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  UBI FMDV A22 A Mahmatli/Tur/65Y, VP1. Peptides with both 134 and 
       158 AA positions substituted by Cys and cyclized.

<400>  20

Val Tyr Asn Gly Thr Cys Lys Tyr Ser Ala Gly Gly Thr Gly Arg Arg 
1               5                   10                  15      


Gly Asp Leu Gly Pro Leu Ala Ala Arg Val Ala Ala Cys Leu Pro Ala 
            20                  25                  30          


Ser Phe Asn Phe Gly Ala Ile Gln 
        35                  40  


<210>  21
<211>  40
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  UBI FMDV A Argentina 2001Y, VP1. Peptides with both 134 and 158 
       AA positions substituted by Cys and cyclized.

<400>  21

Val Tyr Asn Gly Thr Cys Lys Tyr Thr Val Ser Gly Ser Ser Arg Arg 
1               5                   10                  15      


Gly Asp Leu Gly Ser Leu Ala Ala Arg Val Val Lys Cys Leu Pro Ala 
            20                  25                  30          


Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40  


<210>  22
<211>  38
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(38)
<223>  UBI FMDV C3 Indaial/Brazil/84Y, VP1. Peptides with both 134 and 
       158 AA positions substituted by Cys and cyclized.

<400>  22

Thr Tyr Thr Gly Thr Cys Ala Tyr Thr Ala Ser Ala Arg Arg Gly Asp 
1               5                   10                  15      


Leu Ala His Leu Ala Ala Ala His Ala Arg Cys Leu Pro Thr Ser Phe 
            20                  25                  30          


Asn Phe Gly Ala Val Lys 
        35              


<210>  23
<211>  38
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(38)
<223>  UBI FMDV C3 Argentina/83c, VP1. Peptides with both 134 and 158 AA
       positions substituted by Cys and cyclized.

<400>  23

Thr Tyr Thr Gly Thr Cys Thr Tyr Thr Thr Ser Ala Arg Arg Gly Asp 
1               5                   10                  15      


Leu Ala His Leu Ala Thr Ala His Ala Arg Cys Leu Pro Thr Ser Phe 
            20                  25                  30          


Asn Phe Gly Ala Val Lys 
        35              


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Combinatorial modified T helper peptide from Measles virus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<400>  24

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe 
            


<210>  25
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitope from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Artificial combinatorial modified T helper peptide sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  linked spacer, K (20) is epsilon K.

<220>
<221>  MISC_FEATURE
<222>  (21)..(61)
<223>  UBI FMDV VP1 2570a, with both 134 and 158 AA positions 
       substituted by Cys and cyclized.

<400>  25

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Tyr Asn Gly Asn Cys Lys Tyr Gly Glu Asn Ala 
            20                  25                  30          


Val Thr Asn Val Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala 
        35                  40                  45              


Arg Cys Leu Pro Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
    50                  55                  60      


<210>  26
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitope from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Combinatorial modified T helper peptide sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Linked spacer, K (20) is epsilon K.

<220>
<221>  MISC_FEATURE
<222>  (21)..(61)
<223>  UBI FMDV VP1 O Campos/Brazil/58Y, with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  26

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Tyr Asn Gly Glu Cys Arg Tyr Ser Arg Asn Ala 
            20                  25                  30          


Val Pro Asn Val Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Val Ala 
        35                  40                  45              


Arg Cys Leu Pro Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
    50                  55                  60      


<210>  27
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitope from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Artificial combinatorial modified T helper peptide sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Linked spacer, K (20) is epsilon K.

<220>
<221>  MISC_FEATURE
<222>  (21)..(61)
<223>  UBI FMDV VP1 O swine/Cattle/O/MYA/7/02, with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  27

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Tyr Asn Gly Asn Cys Lys Tyr Ala Gly Gly Ser 
            20                  25                  30          


Leu Thr Asn Val Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala 
        35                  40                  45              


Arg Cys Leu Pro Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
    50                  55                  60      


<210>  28
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitope from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Artificial combinatorial modified T helper peptide sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Linked spacer K(20) is epsilon K.

<220>
<221>  MISC_FEATURE
<222>  (21)..(61)
<223>  UBI FMDV VP1 O/Ozk/93, with both 134 and 158 AA positions 
       substituted by Cys and cyclized.

<400>  28

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Tyr Asn Gly Asn Cys Lys Tyr Ser Asp Arg Ala 
            20                  25                  30          


Val Ser Asn Val Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala 
        35                  40                  45              


Arg Cys Leu Pro Thr Ser Phe Asn Tyr Gly Ala Ile Lys 
    50                  55                  60      


<210>  29
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitope from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Artificial combinatorial modified T helper peptide sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Linked spacer, K (20) is epsilon K.

<220>
<221>  MISC_FEATURE
<222>  (21)..(59)
<223>  UBI FMDV VP1 Asia 1 JiangSu/China/2005, with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  29

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Tyr Asn Gly Lys Cys Thr Tyr Gly Glu Glu Ser 
            20                  25                  30          


Ser Arg Arg Gly Asp Leu Ala Ala Leu Ala Arg Arg Val Asn Asn Cys 
        35                  40                  45              


Leu Pro Thr Ser Phe Asn Tyr Gly Ala Val Lys 
    50                  55                  


<210>  30
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitope from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Artificial combinatorial modified T helper peptide sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Linked spacer, K (20) is epsilon k.

<220>
<221>  MISC_FEATURE
<222>  (21)..(60)
<223>  UBI FMDV VP1 A24 Cruzeiro California, with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  30

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Tyr Asn Gly Thr Ser Lys Tyr Ala Val Gly Gly 
            20                  25                  30          


Ser Gly Arg Arg Gly Asp Met Gly Ser Leu Ala Ala Arg Val Val Lys 
        35                  40                  45              


Gln Leu Pro Ala Ser Phe Asn Tyr Gly Ala Ile Lys 
    50                  55                  60  


<210>  31
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitope from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Artificial combinatorial modified T helper peptide sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Linked spacer, K (20) is epsilon K.

<220>
<221>  MISC_FEATURE
<222>  (21)..(60)
<223>  UBI FMDV VP1 A Gansu/China/60Y, with both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  31

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Tyr Asn Gly Thr Cys Gln Tyr Ser Thr Gly Asn 
            20                  25                  30          


Ala Gly Arg Arg Gly Asp Leu Gly Ser Leu Ala Arg Val Ala Ala Gln 
        35                  40                  45              


Cys Leu Pro Ala Ser Phe Asn Phe Gly Ala Ile Arg 
    50                  55                  60  


<210>  32
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitope from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Artificial combinatorial modified T helper peptide sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Linked spacer, K (20) is epsilon K.

<220>
<221>  MISC_FEATURE
<222>  (21)..(58)
<223>  UBI FMDV VP1 C3 Indaial/Brazil/84Y, with VP1 both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  32

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Thr Tyr Thr Gly Thr Cys Ala Tyr Thr Ala Ser Ala 
            20                  25                  30          


Arg Arg Gly Asp Leu Ala His Leu Ala Ala Ala His Ala Arg Cys Leu 
        35                  40                  45              


Pro Thr Ser Phe Asn Phe Gly Ala Val Lys 
    50                  55              


<210>  33
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitope from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Artificial combinatorial modified T helper peptide sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Linked spacer, K (20) is epsilon K.

<220>
<221>  MISC_FEATURE
<222>  (21)..(60)
<223>  UBI FMDV VP1 A Argentina 2001, with VP1 both 134 and 158 AA 
       positions substituted by Cys and cyclized.

<400>  33

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Tyr Asn Gly Thr Ser Lys Tyr Thr Val Ser Gly 
            20                  25                  30          


Ser Ser Arg Arg Gly Asp Leu Gly Ser Leu Ala Ala Arg Val Val Lys 
        35                  40                  45              


Ala Leu Pro Ala Ser Phe Asn Tyr Gly Ala Ile Lys 
    50                  55                  60  


<210>  34
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (S221-M235)  [FMDV VP4 20-35].

<400>  34

Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser Met 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (I223-T237)[FMDV VP4 22-36].

<400>  35

Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser Met Asp Thr 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P369-K374)[FMDV VP2 74-88].

<400>  36

Pro Phe Gly Arg Cys Tyr Leu Leu Glu Leu Pro Thr Asp His Lys 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (D582-A596) [FMDV VP3 78-92].

<400>  37

Asp Leu Ser Leu Ala Ala Lys His Met Ser Asn Thr Phe Leu Ala 
1               5                   10                  15  


<210>  38
<211>  20
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  AJ539137 FMDV O, strain TAW/2/99 (E745-V7964)[FMDV VP1 21-40].

<400>  38

Glu Thr Gln Val Gln Arg Arg Gln His Thr Asp Val Ser Phe Ile Leu 
1               5                   10                  15      


Asp Arg Phe Val 
            20  


<210>  39
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (I759-N773) [VP1 35-49].

<400>  39

Ile Leu Asp Arg Phe Val Lys Val Thr Pro Lys Asp Gln Ile Asn 
1               5                   10                  15  


<210>  40
<211>  19
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  AJ539137 FMDV O, strain TAW/2/99 (I759-L777)[FMDV VP1 35-53].

<400>  40

Ile Leu Asp Arg Phe Val Lys Val Thr Pro Lys Asp Gln Ile Asn Val 
1               5                   10                  15      


Leu Asp Leu 
            


<210>  41
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (V786-L800)[FMDV VP1 62-76].

<400>  41

Val Gly Ala Leu Leu Arg Thr Ala Thr Tyr Tyr Phe Ala Asp Leu 
1               5                   10                  15  


<210>  42
<211>  21
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  AJ539137 FMDV O, strain TAW/2/99 (G808-P828)[FMDV VP1 84-104].

<400>  42

Gly Asn Leu Thr Trp Val Pro Asn Gly Ala Pro Glu Thr Ala Leu Asp 
1               5                   10                  15      


Asn Thr Thr Asn Pro 
            20      


<210>  43
<211>  22
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P835-G856)[FMDV VP1 111-132].

<400>  43

Pro Leu Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu 
1               5                   10                  15      


Ala Thr Val Tyr Asn Gly 
            20          


<210>  44
<211>  17
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  AJ539137 FMDV O, strain TAW/2/99 (T895-C911)[FMDV VP1 167-183].

<400>  44

Thr Arg Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr 
1               5                   10                  15      


Cys 
    


<210>  45
<211>  22
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P912-V933)[FMDV VP1 188-209].

<400>  45

Pro Arg Pro Leu Leu Ala Ile His Pro Ser Lys Ala Arg His Lys Gln 
1               5                   10                  15      


Lys Ile Val Ala Pro Val 
            20          


<210>  46
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (R924-L937)[FMDV VP1 200-213].

<400>  46

Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Leu Leu 
1               5                   10                  


<210>  47
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99  (P954-V968) [FMDV 2B 1-15].

<400>  47

Pro Phe Phe Phe Ser Asp Val Arg Ser Asn Phe Ser Lys Leu Val 
1               5                   10                  15  


<210>  48
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (F1093-K1106) [FMDV 2B 140-153].

<400>  48

Phe Phe Arg Ser Thr Pro Glu Asp Leu Glu Arg Ala Glu Lys 
1               5                   10                  


<210>  49
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99  (L1108-N1122) [FMDV 2C 1-15].

<400>  49

Leu Lys Ala Arg Asp Ile Asn Asp Ile Phe Ala Ile Leu Lys Asn 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (S1143-I1157) [FMDV 2C 36-50].

<400>  50

Ser Glu Glu Lys Phe Val Thr Met Thr Asp Leu Val Pro Gly Ile 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (V1148-R1162) [FMDV 2C 41-55].

<400>  51

Val Thr Met Thr Asp Leu Val Pro Gly Ile Leu Glu Lys Gln Arg 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (A1446-K1450) [FMDV 3A 21-35].

<400>  52

Ala Ala Ile Glu Phe Phe Glu Gly Met Val His Asp Ser Ile Lys 
1               5                   10                  15  


<210>  53
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (N1516-K1529) [FMDV 3A 91-104].

<400>  53

Asn Glu Tyr Ile Glu Lys Ala Ser Ile Thr Thr Asp Asp Lys 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (T1551-L1564) [FMDV 3A 101-114].

<400>  54

Thr Asp Asp Lys Thr Leu Asp Glu Ala Glu Lys Asn Pro Leu 
1               5                   10                  


<210>  55
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (E1551-N1564) [FMDV 3A 126-139].

<400>  55

Glu Lys Thr Leu Pro Gly His Lys Ala Ser Asp Asp Val Asn 
1               5                   10                  


<210>  56
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (G1579-K1592) [FMDV 3B1 1-14].

<400>  56

Gly Pro Tyr Ala Gly Pro Met Glu Arg Gln Lys Pro Leu Lys 
1               5                   10                  


<210>  57
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P1584-L1597) [FMDV 3B1 6-19].

<400>  57

Pro Leu Glu Arg Gln Lys Pro Leu Lys Val Arg Ala Lys Leu 
1               5                   10                  


<210>  58
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P1607-A1620) [FMDV 3B2 6-19].

<400>  58

Pro Met Glu Arg Gln Lys Pro Leu Lys Val Lys Val Lys Ala 
1               5                   10                  


<210>  59
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P1631-N1644) [FMDV 3B3 6-19].

<400>  59

Pro Val Lys Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn 
1               5                   10                  


<210>  60
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (M1878-F1892) [FMDV 3D 16-30].

<400>  60

Met Arg Lys Thr Lys Leu Ala Pro Thr Val Ala His Gly Val Phe 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (I1918-D1932)[FMDV 3D 56-70].

<400>  61

Ile Phe Ser Lys His Lys Gly Asn Thr Lys Met Ser Glu Glu Asp 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (A2108-V2122)[FMDV 3D 246-260].

<400>  62

Ala Asn His Cys Ser Asp Ala Met Asn Ile Met Phe Glu Glu Val 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (L2248-K2262)[FMDV 3D 386-400].

<400>  63

Leu Lys Arg His Phe His Met Asp Tyr Gly Thr Gly Phe Tyr Lys 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (I1918-D1932) as homologue of 
       [FMDV 3D 56-70].

<400>  64

Leu Phe Ser Arg His Arg Gly Asn Thr Lys Met Ser Glu Glu Asp 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (A2108-V2122) as homologue of 
       [FMDV 3D 246-260].

<400>  65

Ala Asn His Cys Ser Asp Ala Met Asn Leu Met Phe Glu Glu Val 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (L2248-K2262) as homologue of 
       [FMDV 3D386-400].

<400>  66

Ile Arg Lys His Phe His Met Asp Tyr Gly Thr Gly Phe Tyr Arg 
1               5                   10                  15  


<210>  67
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (F1093-K1106) as homologue of 
       [FMDV 2B 140-153].

<400>  67

Phe Phe Lys Ser Thr Pro Glu Asp Val Glu Lys Ala Glu Arg 
1               5                   10                  


<210>  68
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (F1093-K1106) as homologue of 
       [FMDV 2B 140-153].

<400>  68

Phe Phe Arg Ser Thr Pro Glu Glu Ile Glu Arg Ala Glu Lys 
1               5                   10                  


<210>  69
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (N1516-K1529) as homologue of 
       [FMDV 3A 91-104].

<400>  69

Asn Asp Tyr Leu Glu Arg Ala Asn Leu Thr Thr Asp Pro Arg 
1               5                   10                  


<210>  70
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (N1516-K1529) as homologue of 
       [FMDV 3A 91-104].

<400>  70

Asn Glu Tyr Ile Glu Lys Val Ser Ile Thr Thr Asp Asp Lys 
1               5                   10                  


<210>  71
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (M1878-F1892) as homologue of 
       [FMDV 3D 16-30].

<400>  71

Met Lys Arg Thr Arg Ile Ala Pro Thr Leu Ala His Gly Ile Phe 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (M1878-F1892) as homologue of 
       [FMDV 3D 16-30].

<400>  72

Met Arg Lys Thr Lys Val Ala Pro Thr Ile Ala His Gly Leu Phe 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (S221-M235) as homologue of 
       [FMDV VP4 20-34].

<400>  73

Ser Leu Leu Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser Met 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (S221-M235) as homologue of 
       [FMDV VP4 20-34].

<400>  74

Ser Val Val Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser Met 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P360-K374) as homologue of 
       [FMDV VP2 74-88].

<400>  75

Pro Phe Gly Lys Cys Tyr Ile Ile Glu Ile Pro Thr Asp His Arg 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P360-K374) as homologue of 
       [FMDV VP2 74-88].

<400>  76

Pro Phe Gly Arg Cys Tyr Val Val Glu Val Pro Thr Asp His Lys 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (D582-A596) as homologue of 
       [FMDV VP3 78-92].

<400>  77

Asp Val Ser Ile Ala Ala Gly His Met Ser Asn Thr Tyr Leu Ser 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (D582-A596) as homologue of 
       [FMDV VP3 78-92].

<400>  78

Asp Val Ser Val Ala Ala Lys His Met Ser Asn Thr Phe Leu Val 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (I1918-D1932)[FMDV 3D 56-70].

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  I or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  K or R

<400>  79

Xaa Phe Ser Xaa His Xaa Gly Asn Thr Xaa Met Ser Glu Glu Asp 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O strain TAW/2/99 (A2108-V2122)[FMDV 3D 246-260].

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  I or L

<400>  80

Ala Asn His Cys Ser Asp Ala Met Asn Xaa Met Phe Glu Glu Val 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (L2248-K2262)[FMDV 3D386-400].

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  L or I

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  K or R

<400>  81

Xaa Xaa Xaa His Phe His Met Asp Tyr Gly Thr Gly Phe Tyr Xaa 
1               5                   10                  15  


<210>  82
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (F1093-K1106) [FMDV 2B 140-153].

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  K or R

<400>  82

Phe Phe Xaa Ser Thr Pro Glu Xaa Xaa Glu Xaa Ala Glu Xaa 
1               5                   10                  


<210>  83
<211>  14
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  AJ539137 FMDV O, strain TAW/2/99 (N1516-K1529) (FMDV 3A 91-104)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  E or D

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  I or L

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  N or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  I or L

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  D or P

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  K or R

<400>  83

Asn Xaa Tyr Xaa Glu Xaa Ala Xaa Xaa Thr Thr Asp Xaa Xaa 
1               5                   10                  


<210>  84
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (M1878-F1892) [FMDV 3D 16-30].

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  V or L or I

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  V or I or L

<400>  84

Met Xaa Xaa Thr Xaa Xaa Ala Pro Thr Val Ala His Gly Val Phe 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99  (S221-M235) [FMDV VP4 20-34].

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  I or L or V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  I or L or V

<400>  85

Ser Xaa Xaa Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser Met 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P360-K374)[FMDV VP2 74-88].

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  K or R

<400>  86

Pro Phe Gly Xaa Cys Tyr Xaa Xaa Glu Xaa Pro Thr Asp His Xaa 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (D582-A596) [FMDV VP3 78-92].

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or G

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  F or Y

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  A or S or V

<400>  87

Asp Xaa Ser Leu Ala Ala Xaa His Met Ser Asn Thr Xaa Leu Xaa 
1               5                   10                  15  


<210>  88
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitopes from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Combinatorial modified T helper sequence.

<220>
<221>  MISC_FEATURE
<222>  (1)..(65)
<223>  UBITh(R) 3-K- [FMDV 2B 140-153]-K- [FMDV 3A 91-104]-K-[FMDV 3D 
       16-30] from AJ539137 FMDV O, strain TAW/2/99.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  K is linked spacer.

<400>  88

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Phe Phe Arg Ser Thr Pro Glu Asp Leu Glu Arg Ala 
            20                  25                  30          


Glu Lys Lys Asn Glu Tyr Ile Glu Lys Ala Ser Ile Thr Thr Asp Asp 
        35                  40                  45              


Lys Lys Met Arg Lys Thr Lys Leu Ala Pro Thr Val Ala His Gly Val 
    50                  55                  60                  


Phe 
65  


<210>  89
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitopes from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  Combinatorial modified T helper sequence.

<220>
<221>  MISC_FEATURE
<222>  (1)..(67)
<223>  UBITh(R) 3-K- [FMDV VP4 20-34]-K-[FMDV VP2 74-88]-K-[FMDV 
       VP378-92] from AJ539137 FMDV O, strain TAW/2/99.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  k is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  k is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  K is linked spacer.

<400>  89

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Lys Pro Phe Gly Arg Cys Tyr Leu Leu Glu Leu Pro Thr 
        35                  40                  45              


Asp His Lys Lys Asp Leu Ser Leu Ala Ala Lys His Met Ser Asn Thr 
    50                  55                  60                  


Phe Leu Ala 
65          


<210>  90
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitopes from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Combinatorial modified T helper sequence.

<220>
<221>  MISC_FEATURE
<222>  (1)..(67)
<223>  UBITh(R) 3-K-[FMDV 3D 56-70]-K-[FMDV 3D 248-260]-K-[FMDV 3D 
       386-400] AJ539137 FMDV O, strain TAW/2/99.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  K is linked spacer sequence.

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  I or L

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  I or L

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  L or I

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  K or R

<400>  90

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Xaa Phe Ser Xaa His Xaa Gly Asn Thr Xaa Met Ser 
            20                  25                  30          


Glu Glu Asp Lys Ala Asn His Cys Ser Asp Ala Met Asn Xaa Met Phe 
        35                  40                  45              


Glu Glu Val Lys Xaa Xaa Xaa His Phe His Met Asp Tyr Gly Thr Gly 
    50                  55                  60                  


Phe Tyr Xaa 
65          


<210>  91
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitopes from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Combinatorial modified T helper sequence.

<220>
<221>  MISC_FEATURE
<222>  (1)..(65)
<223>  UBITh(R) 3-K- [FMDV 2B 140-153]-K-[FMDV 3A 91-104]-K-[FMDV 3D 
       16-30] from  AJ539137 FMDV O, strain TAW/2/99.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  E or D

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  I or L

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  N or S

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  I or L

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  D or P

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  V or L or I

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  V or I or L

<400>  91

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Phe Phe Xaa Ser Thr Pro Glu Xaa Xaa Glu Xaa Ala 
            20                  25                  30          


Glu Xaa Lys Asn Xaa Tyr Xaa Glu Xaa Ala Xaa Xaa Thr Thr Asp Asp 
        35                  40                  45              


Xaa Lys Met Xaa Lys Thr Xaa Xaa Ala Pro Thr Val Ala His Gly Val 
    50                  55                  60                  


Phe 
65  


<210>  92
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitopes from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(67)
<223>  UBITh(R) 3-K- [FMDV VP420-34]-K-[FMDV VP2 74-88]-K- [FMDV VP3 
       78-92] from AJ539137 FMDV O, strain TAW/2/99.

<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Combinatorial T helper sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  I or L or V

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  I or L or V

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  P or A

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  H or R or K

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  L or C or S

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  E or H or Y

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  T or A or S

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  H or K or R

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  L or V

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  K or G

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  F or Y

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  A or S or V

<400>  92

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Ser Xaa Xaa Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Lys Xaa Phe Gly Xaa Xaa Xaa Xaa Xaa Glu Xaa Pro Xaa 
        35                  40                  45              


Xaa His Xaa Lys Asp Xaa Ser Ile Ala Ala Xaa His Met Ser Asn Thr 
    50                  55                  60                  


Xaa Leu Xaa 
65          


<210>  93
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitopes from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Combinatorial T helper sequence.

<220>
<221>  MISC_FEATURE
<222>  (1)..(67)
<223>  UBITh(R) 3-K- FMDV Th library from polyprotein type O, A, C and 
       Asia-1 and type O-1 (ABR19839) sequence based construct 
       [S221-M235]-K-[P360-K374]-K-[D582-A596].

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  I or L or V

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  I or L or V

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  P or N or S or A

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  R or H or K

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C or M or I or S

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Y or H or E

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  T or S or H

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  H or P

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  L or V

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  A or S

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  K or R or G

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  S or A

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  F or Y

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  A or S

<400>  93

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Ser Xaa Xaa Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Lys Xaa Phe Gly Xaa Xaa Xaa Xaa Xaa Glu Xaa Pro Xaa 
        35                  40                  45              


Xaa Xaa Xaa Lys Asp Xaa Ser Xaa Ala Ala Xaa His Met Xaa Asn Thr 
    50                  55                  60                  


Xaa Leu Xaa 
65          


<210>  94
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitopes from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Combinatorial T helper sequence.

<220>
<221>  MISC_FEATURE
<222>  (1)..(84)
<223>  UBITh(R) 3-K- FMDV Th library from polyprotein type O, A, C and 
       Asia-1 and type O-1 (ABR19839) sequence based construct 
       [I759-L777]-K-[G808-P828]-K-[P912-V933].

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  I or V

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  L or M

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  K or Q or E

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  V or L or I

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  T or Q or K

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  P or V or A

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  K or S or V

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  D or S or K

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Q or N or P

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  I or T or Q

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  N or H or Q

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  V or T or I

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  L or I

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  D or M

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  L or V or M

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  N or K or P

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  L or V or A

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  A or S

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  P or K

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  E or V or D

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  T or A

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  D or E or N

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  T or Q or H

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  L or I

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  A or P

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  I or L or V

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  H or D or Q

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  P or T or V

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  S or T or N

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  K or Q or G

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  A or D

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  H or R

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  K or E or P

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  I or L

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  V or E or A

<400>  94

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Xaa Xaa Asp Arg Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Gly Xaa Xaa Thr Trp Val Pro Asn 
        35                  40                  45              


Gly Xaa Pro Xaa Xaa Ala Leu Xaa Asn Xaa Xaa Asn Pro Lys Pro Arg 
    50                  55                  60                  


Pro Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Lys Gln Xaa Xaa 
65                  70                  75                  80  


Xaa Ala Pro Xaa 
                


<210>  95
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide containing artificial T helper epitope from measles virus
       and B cell epitopes from foot-and-mouth disease virus (FMDV)


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Combinatorial T helper sequence.

<220>
<221>  MISC_FEATURE
<222>  (1)..(74)
<223>  UBITh(R) 3-K- FMDV Th library from polyprotein type O, A, C and 
       Asia-1 and type O-1 (ABR19839) sequence based construct 
       [V786-L800]-K-[P835-G856]-K-[A1446-K1460].

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  L or M

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  T or A or S

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  A or S

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  A or S

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  K is linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  L or V or F

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  N or T

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  K is lined spacer.

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  E or D

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  I or V

<400>  95

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Gly Ala Xaa Leu Arg Xaa Xaa Thr Tyr Tyr Phe 
            20                  25                  30          


Xaa Asp Leu Lys Pro Xaa Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro 
        35                  40                  45              


His Arg Val Leu Ala Thr Xaa Tyr Xaa Gly Lys Ala Ala Ile Glu Phe 
    50                  55                  60                  


Phe Xaa Gly Met Val His Asp Ser Xaa Lys 
65                  70                  


<210>  96
<211>  24
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(24)
<223>  A12 (134-159) from FMDV VP1.

<400>  96

Asn Lys Tyr Ser Ala Ser Gly Ser Gly Val Arg Gly Asp Phe Gly Ser 
1               5                   10                  15      


Leu Ala Pro Arg Val Ala Arg Gln 
            20                  


<210>  97
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(35)
<223>  A12 (134-169) from FMDV VP1.

<400>  97

Asn Lys Tyr Ser Ala Ser Gly Ser Gly Val Arg Gly Asp Phe Gly Ser 
1               5                   10                  15      


Leu Ala Pro Arg Val Ala Arg Gln Leu Pro Ala Ser Phe Asn Tyr Gly 
            20                  25                  30          


Ala Ile Lys 
        35  


<210>  98
<211>  35
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(35)
<223>  A12 [134(N-C) -158(Q-C) -169] from FMDV VP1, cyclized.

<400>  98

Cys Lys Tyr Ser Ala Ser Gly Ser Gly Val Arg Gly Asp Phe Gly Ser 
1               5                   10                  15      


Leu Ala Pro Arg Val Ala Arg Cys Leu Pro Ala Ser Phe Asn Tyr Gly 
            20                  25                  30          


Ala Ile Lys 
        35  


<210>  99
<211>  40
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  A12 [129-134(N-C)-158(Q-C)-169] from FMDV VP1, cyclized.

<400>  99

Val Tyr Asn Gly Thr Cys Lys Tyr Ser Ala Ser Gly Ser Gly Val Arg 
1               5                   10                  15      


Gly Asp Phe Gly Ser Leu Ala Pro Arg Val Ala Arg Cys Leu Pro Ala 
            20                  25                  30          


Ser Phe Asn Tyr Gly Ala Ile Lys 
        35                  40  


<210>  100
<211>  60
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Combinatorial T helper sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  K is epsilon K as a linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (21)..(60)
<223>  A12 [129-134(N-C)-158(Q-C)-169] from FMDV VP1, cyclized.

<400>  100

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Tyr Asn Gly Thr Cys Lys Tyr Ser Ala Ser Gly 
            20                  25                  30          


Ser Gly Val Arg Gly Asp Phe Gly Ser Leu Ala Pro Arg Val Ala Arg 
        35                  40                  45              


Cys Leu Pro Ala Ser Phe Asn Tyr Gly Ala Ile Lys 
    50                  55                  60  


<210>  101
<211>  56
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(56)
<223>  UBITh-K - O library [134-158 (T-C)-169], cyclized

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  K is epsilon K as a linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  G or S

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  E or D

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Q or R

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  A or E

<400>  101

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Cys Lys Tyr Xaa Xaa Asn Ala Val Thr Asn Val Arg 
            20                  25                  30          


Gly Asp Leu Xaa Val Leu Ala Gln Lys Ala Xaa Arg Cys Leu Pro Thr 
        35                  40                  45              


Ser Phe Asn Tyr Gly Ala Ile Lys 
    50                  55      


<210>  102
<211>  59
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Combinatorial T helper sequence.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  K is epsilon K as a linked spacer.

<220>
<221>  MISC_FEATURE
<222>  (21)..(59)
<223>  Asia library [129-134(T-C)-158(R-C)-169] from FMDV VP1, cyclized

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  R or T

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  R or E

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Q or L

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  T or V

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  F or N

<400>  102

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Val Tyr Asn Gly Lys Cys Thr Tyr Gly Glu Gln Pro 
            20                  25                  30          


Ser Xaa Xaa Gly Asp Met Ala Ala Leu Ala Xaa Arg Leu Ser Arg Cys 
        35                  40                  45              


Leu Pro Xaa Ser Xaa Asn Tyr Gly Ala Val Lys 
    50                  55                  


<210>  103
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P360-K374) as homologue of 
       [FMDV VP2 74-88].

<400>  103

Pro Phe Gly Lys Ser Tyr Ile Ile Glu Ile Pro Thr Asp His Arg 
1               5                   10                  15  


<210>  104
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P360-K374) as homologue of 
       [FMDV VP2 74-88].

<400>  104

Pro Phe Gly Arg Ser Tyr Val Val Glu Val Pro Thr Asp His Lys 
1               5                   10                  15  


<210>  105
<211>  15
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  AJ539137 FMDV O, strain TAW/2/99 (P360-K374)[FMDV VP2 74-88].

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  S or C

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  L or I or V

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  K or R

<400>  105

Pro Phe Gly Xaa Xaa Tyr Xaa Xaa Glu Xaa Pro Thr Asp His Xaa 
1               5                   10                  15  


<210>  106
<211>  211
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(211)
<223>  NCBI Reference Sequence: NP_740460.1

<400>  106

Thr Thr Ser Ala Gly Glu Ser Ala Asp Pro Val Thr Ala Thr Val Glu 
1               5                   10                  15      


Asn Tyr Gly Gly Glu Thr Gln Val Gln Arg Arg Gln His Thr Asp Ile 
            20                  25                  30          


Ala Phe Ile Leu Asp Arg Phe Val Lys Val Lys Pro Lys Glu Gln Val 
        35                  40                  45              


Asn Val Leu Asp Leu Met Gln Ile Pro Ala His Thr Leu Val Gly Ala 
    50                  55                  60                  


Leu Leu Arg Thr Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Leu Ala Val 
65                  70                  75                  80  


Lys His Glu Gly Asp Leu Thr Trp Val Pro Asn Gly Ala Pro Glu Thr 
                85                  90                  95      


Ala Leu Asp Asn Thr Thr Asn Pro Thr Ala Tyr His Lys Glu Pro Leu 
            100                 105                 110         


Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr 
        115                 120                 125             


Val Tyr Asn Gly Ser Ser Lys Tyr Gly Asp Thr Ser Thr Asn Asn Val 
    130                 135                 140                 


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Glu Arg Thr Leu Pro 
145                 150                 155                 160 


Thr Ser Phe Asn Phe Gly Ala Ile Lys Ala Thr Arg Val Thr Glu Leu 
                165                 170                 175     


Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro Arg Pro Leu Leu 
            180                 185                 190         


Ala Ile Gln Pro Ser Asp Ala Arg His Lys Gln Arg Ile Val Ala Pro 
        195                 200                 205             


Ala Lys Gln 
    210     


<210>  107
<211>  2332
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(2332)
<223>  GenBank: AJ539137.1

<400>  107

Met Ser Thr Thr Asp Cys Phe Ile Ala Leu Leu Tyr Ala Phe Arg Glu 
1               5                   10                  15      


Ile Lys Thr Leu Phe Leu Ser Arg Ala Gln Gly Lys Met Glu Phe Thr 
            20                  25                  30          


Leu His Asn Gly Glu Arg Lys Thr Phe Tyr Ser Arg Pro Asn Asn His 
        35                  40                  45              


Asp Asn Cys Trp Leu Asn Thr Ile Leu Gln Leu Phe Arg Tyr Val Asp 
    50                  55                  60                  


Glu Pro Phe Phe Asp Trp Val Tyr Tyr Ser Pro Glu Asn Leu Thr Leu 
65                  70                  75                  80  


Asp Ala Ile Lys Gln Leu Glu Glu Ile Thr Gly Leu Glu Leu His Glu 
                85                  90                  95      


Gly Gly Pro Pro Ala Leu Val Ile Trp Asn Ile Lys His Leu Leu Asn 
            100                 105                 110         


Thr Gly Ile Gly Thr Ala Ser Arg Pro Ser Glu Val Cys Met Val Asp 
        115                 120                 125             


Gly Thr Asp Met Cys Leu Ala Asp Phe His Ala Gly Ile Phe Leu Lys 
    130                 135                 140                 


Gly Gln Glu His Ala Val Phe Ala Cys Val Thr Ser Asn Gly Trp Tyr 
145                 150                 155                 160 


Ala Ile Asp Asp Glu Asp Phe Tyr Pro Trp Thr Pro Asp Pro Ser Asp 
                165                 170                 175     


Val Leu Val Phe Val Pro Tyr Asp Gln Glu Pro Leu Asn Gly Glu Trp 
            180                 185                 190         


Lys Ala Lys Val Gln Lys Arg Leu Arg Gly Ala Gly Gln Ser Ser Pro 
        195                 200                 205             


Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn Thr Gly Ser Ile Ile Asn 
    210                 215                 220                 


Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser Met Asp Thr Gln Leu Gly 
225                 230                 235                 240 


Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu Gly Ser Thr Asp Thr Thr 
                245                 250                 255     


Ser Thr His Thr Thr Asn Thr Gln Asn Asn Asp Trp Phe Ser Lys Leu 
            260                 265                 270         


Ala Ser Ser Ala Phe Ser Gly Leu Phe Gly Ala Leu Leu Ala Asp Lys 
        275                 280                 285             


Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile Leu Thr Thr Arg 
    290                 295                 300                 


Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val Gly Val Thr Tyr 
305                 310                 315                 320 


Gly Tyr Ala Thr Ala Glu Asp Phe Val Ser Gly Pro Asn Thr Ser Gly 
                325                 330                 335     


Leu Glu Thr Arg Val Val Gln Ala Glu Arg Phe Phe Lys Thr His Leu 
            340                 345                 350         


Phe Asp Trp Val Thr Ser Asp Pro Phe Gly Arg Cys Tyr Leu Leu Glu 
        355                 360                 365             


Leu Pro Thr Asp His Lys Gly Val Tyr Gly Ser Leu Thr Asp Ser Tyr 
    370                 375                 380                 


Ala Tyr Met Arg Asn Gly Trp Asp Val Glu Val Thr Ala Val Gly Asn 
385                 390                 395                 400 


Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Met Val Pro Glu Leu Cys 
                405                 410                 415     


Ser Ile Asp Lys Arg Glu Leu Tyr Gln Leu Thr Leu Phe Pro His Gln 
            420                 425                 430         


Phe Ile Asn Pro Arg Thr Asn Met Thr Ala His Ile Thr Val Pro Phe 
        435                 440                 445             


Val Gly Val Asn Arg Tyr Asp Gln Tyr Lys Val His Lys Pro Trp Thr 
    450                 455                 460                 


Leu Val Val Met Val Val Ala Pro Leu Thr Val Asn Thr Glu Gly Ala 
465                 470                 475                 480 


Pro Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr Asn Val His Val 
                485                 490                 495     


Ala Gly Glu Phe Pro Ser Lys Glu Gly Ile Phe Pro Val Ala Cys Ser 
            500                 505                 510         


Asp Gly Tyr Gly Gly Leu Val Thr Thr Asp Pro Lys Thr Ala Asp Pro 
        515                 520                 525             


Ala Tyr Gly Lys Val Phe Asn Pro Pro Arg Asn Met Leu Pro Gly Arg 
    530                 535                 540                 


Phe Thr Asn Phe Leu Asp Val Ala Glu Ala Cys Pro Thr Phe Leu His 
545                 550                 555                 560 


Phe Glu Gly Asp Val Pro Tyr Val Thr Thr Lys Thr Asp Ser Asp Arg 
                565                 570                 575     


Val Leu Ala Gln Phe Asp Leu Ser Leu Ala Ala Lys His Met Ser Asn 
            580                 585                 590         


Thr Phe Leu Ala Gly Leu Ala Gln Tyr Tyr Thr Gln Tyr Ser Gly Thr 
        595                 600                 605             


Ile Asn Leu His Phe Met Phe Thr Gly Pro Thr Asp Ala Lys Ala Arg 
    610                 615                 620                 


Tyr Met Ile Ala Tyr Ala Pro Pro Gly Met Glu Pro Pro Lys Thr Pro 
625                 630                 635                 640 


Glu Ala Ala Ala His Cys Ile His Ala Glu Trp Asp Thr Gly Leu Asn 
                645                 650                 655     


Ser Lys Phe Thr Phe Ser Ile Pro Tyr Leu Ser Ala Ala Asp Tyr Ala 
            660                 665                 670         


Tyr Thr Ala Ser Asp Val Ala Glu Thr Thr Asn Val Gln Gly Trp Val 
        675                 680                 685             


Cys Leu Phe Gln Ile Thr His Gly Lys Ala Asp Gly Asp Ala Leu Val 
    690                 695                 700                 


Val Leu Ala Ser Ala Gly Lys Asp Phe Glu Leu Arg Leu Pro Val Asp 
705                 710                 715                 720 


Ala Arg Thr Gln Thr Thr Ser Thr Gly Glu Ser Ala Asp Pro Val Thr 
                725                 730                 735     


Ala Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln Val Gln Arg Arg Gln 
            740                 745                 750         


His Thr Asp Val Ser Phe Ile Leu Asp Arg Phe Val Lys Val Thr Pro 
        755                 760                 765             


Lys Asp Gln Ile Asn Val Leu Asp Leu Val Gln Thr Pro Ala His Thr 
    770                 775                 780                 


Leu Val Gly Ala Leu Leu Arg Thr Ala Thr Tyr Tyr Phe Ala Asp Leu 
785                 790                 795                 800 


Glu Val Ala Val Lys His Glu Gly Asn Leu Thr Trp Val Pro Asn Gly 
                805                 810                 815     


Ala Pro Glu Thr Ala Leu Asp Asn Thr Thr Asn Pro Thr Ala Tyr His 
            820                 825                 830         


Lys Ala Pro Leu Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg 
        835                 840                 845             


Val Leu Ala Thr Val Tyr Asn Gly Asn Cys Lys Tyr Gly Glu Ser Pro 
    850                 855                 860                 


Val Thr Asn Val Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala 
865                 870                 875                 880 


Arg Thr Leu Pro Thr Ser Phe Asn Tyr Gly Ala Ile Lys Ala Thr Arg 
                885                 890                 895     


Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
            900                 905                 910         


Arg Pro Leu Leu Ala Ile His Pro Ser Lys Ala Arg His Lys Gln Lys 
        915                 920                 925             


Ile Val Ala Pro Val Lys Gln Leu Leu Asn Phe Asn Leu Leu Lys Leu 
    930                 935                 940                 


Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Phe Phe Phe Ser Asp Val 
945                 950                 955                 960 


Arg Ser Asn Phe Ser Lys Leu Val Glu Thr Ile Asn Gln Met Gln Glu 
                965                 970                 975     


Asp Met Ser Thr Lys His Gly Pro Asp Phe Asn Arg Leu Val Ser Ala 
            980                 985                 990         


Phe Glu Glu Leu Ala Thr Gly Val  Lys Ala Ile Arg Thr  Gly Leu Asp 
        995                 1000                 1005             


Glu Ala  Lys Pro Trp Tyr Lys  Leu Ile Lys Leu Leu  Ser Arg Leu 
    1010                 1015                 1020             


Ser Cys  Met Ala Ala Val Ala  Ala Arg Ser Lys Asp  Pro Val Leu 
    1025                 1030                 1035             


Val Ala  Ile Met Leu Ala Asp  Thr Gly Leu Glu Ile  Leu Asp Ser 
    1040                 1045                 1050             


Thr Phe  Val Val Lys Lys Ile  Ser Asp Ser Leu Ser  Ser Leu Phe 
    1055                 1060                 1065             


His Val  Pro Ala Pro Val Phe  Ser Phe Gly Ala Pro  Ile Leu Leu 
    1070                 1075                 1080             


Ala Gly  Leu Val Lys Val Ala  Ser Ser Phe Phe Arg  Ser Thr Pro 
    1085                 1090                 1095             


Glu Asp  Leu Glu Arg Ala Glu  Lys Gln Leu Lys Ala  Arg Asp Ile 
    1100                 1105                 1110             


Asn Asp  Ile Phe Ala Ile Leu  Lys Asn Gly Glu Trp  Leu Val Lys 
    1115                 1120                 1125             


Leu Ile  Leu Ala Ile Arg Asp  Trp Ile Lys Ala Trp  Ile Ala Ser 
    1130                 1135                 1140             


Glu Glu  Lys Phe Val Thr Met  Thr Asp Leu Val Pro  Gly Ile Leu 
    1145                 1150                 1155             


Glu Lys  Gln Arg Asp Leu Asn  Asp Pro Ser Lys Tyr  Lys Glu Ala 
    1160                 1165                 1170             


Lys Glu  Trp Leu Asp Asn Ala  Arg Gln Ala Cys Leu  Lys Ser Gly 
    1175                 1180                 1185             


Asn Ile  His Ile Ala Asn Leu  Cys Lys Val Val Ala  Pro Ala Pro 
    1190                 1195                 1200             


Ser Arg  Ser Arg Pro Glu Pro  Val Val Val Cys Leu  Arg Gly Lys 
    1205                 1210                 1215             


Ser Gly  Gln Gly Lys Ser Phe  Leu Ala Asn Val Leu  Ala Gln Ala 
    1220                 1225                 1230             


Ile Ser  Thr His Phe Thr Gly  Arg Thr Asp Ser Val  Trp Tyr Cys 
    1235                 1240                 1245             


Pro Pro  Asp Pro Asp His Phe  Asp Gly Tyr Asn Gln  Gln Thr Val 
    1250                 1255                 1260             


Val Val  Met Asp Asp Leu Gly  Gln Asn Pro Asp Gly  Lys Asp Phe 
    1265                 1270                 1275             


Lys Tyr  Phe Ala Gln Met Val  Ser Thr Thr Gly Phe  Ile Pro Pro 
    1280                 1285                 1290             


Met Ala  Ser Leu Glu Asp Lys  Gly Lys Pro Phe Asn  Ser Lys Val 
    1295                 1300                 1305             


Ile Ile  Ala Thr Thr Asn Leu  Tyr Ser Gly Phe Thr  Pro Arg Thr 
    1310                 1315                 1320             


Met Val  Cys Pro Asp Ala Leu  Asn Arg Arg Phe His  Phe Asp Ile 
    1325                 1330                 1335             


Asp Val  Ser Ala Lys Asp Gly  Tyr Lys Ile Asn Asn  Lys Leu Asp 
    1340                 1345                 1350             


Ile Asn  Lys Ala Leu Glu Asp  Thr His Thr Asn Pro  Val Ala Met 
    1355                 1360                 1365             


Phe Gln  Tyr Asp Cys Ala Leu  Leu Asn Gly Met Ala  Val Glu Met 
    1370                 1375                 1380             


Lys Arg  Met Gln Gln Asp Met  Phe Lys Pro Gln Pro  Pro Leu Gln 
    1385                 1390                 1395             


Asn Val  Tyr Gln Leu Val Gln  Glu Val Ile Asp Arg  Val Glu Leu 
    1400                 1405                 1410             


His Glu  Lys Val Ser Ser His  Pro Ile Phe Lys Gln  Ile Ser Ile 
    1415                 1420                 1425             


Pro Ser  Gln Lys Ala Val Leu  Tyr Phe Leu Ile Glu  Lys Gly Gln 
    1430                 1435                 1440             


His Glu  Ala Ala Ile Glu Phe  Phe Glu Gly Met Val  His Asp Ser 
    1445                 1450                 1455             


Ile Lys  Glu Glu Leu Arg Pro  Leu Ile Gln Gln Thr  Ser Phe Val 
    1460                 1465                 1470             


Lys Arg  Ala Phe Lys Arg Leu  Lys Glu Asn Phe Glu  Ile Val Ala 
    1475                 1480                 1485             


Leu Cys  Leu Thr Leu Leu Ala  Asn Ile Val Ile Met  Ile Arg Glu 
    1490                 1495                 1500             


Thr Arg  Lys Arg Gln Gln Met  Val Asp Asp Ala Val  Asn Glu Tyr 
    1505                 1510                 1515             


Ile Glu  Lys Ala Ser Ile Thr  Thr Asp Asp Lys Thr  Leu Asp Glu 
    1520                 1525                 1530             


Ala Glu  Lys Asn Pro Leu Glu  Thr Ser Gly Ala Thr  Thr Val Gly 
    1535                 1540                 1545             


Phe Arg  Glu Lys Thr Leu Pro  Gly His Lys Ala Ser  Asp Asp Val 
    1550                 1555                 1560             


Asn Ser  Glu Pro Ala Lys Pro  Val Glu Glu Gln Pro  Gln Ala Glu 
    1565                 1570                 1575             


Gly Pro  Tyr Thr Gly Pro Leu  Glu Arg Gln Lys Pro  Leu Lys Val 
    1580                 1585                 1590             


Arg Ala  Lys Leu Pro Gln Gln  Glu Gly Pro Tyr Ala  Gly Pro Met 
    1595                 1600                 1605             


Glu Arg  Gln Lys Pro Leu Lys  Val Lys Val Lys Ala  Pro Val Val 
    1610                 1615                 1620             


Lys Glu  Gly Pro Tyr Glu Gly  Pro Val Lys Lys Pro  Val Ala Leu 
    1625                 1630                 1635             


Lys Val  Lys Ala Lys Asn Leu  Ile Val Thr Glu Ser  Gly Ala Pro 
    1640                 1645                 1650             


Pro Thr  Asp Leu Gln Lys Met  Val Met Gly Asn Thr  Lys Pro Val 
    1655                 1660                 1665             


Glu Leu  Ile Leu Asp Gly Lys  Thr Val Ala Ile Cys  Cys Ala Thr 
    1670                 1675                 1680             


Gly Val  Phe Gly Thr Ala Tyr  Leu Val Pro Arg His  Leu Phe Ala 
    1685                 1690                 1695             


Glu Lys  Tyr Asp Lys Ile Met  Leu Asp Gly Arg Ala  Met Thr Asp 
    1700                 1705                 1710             


Ser Asp  Tyr Arg Val Phe Glu  Phe Glu Ile Lys Val  Lys Gly Gln 
    1715                 1720                 1725             


Asp Met  Leu Ser Asp Ala Ala  Leu Met Val Leu His  Arg Gly Asn 
    1730                 1735                 1740             


Arg Val  Arg Asp Ile Thr Lys  His Phe Arg Asp Val  Ala Arg Met 
    1745                 1750                 1755             


Lys Lys  Gly Thr Pro Val Val  Gly Val Ile Asn Asn  Ala Asp Val 
    1760                 1765                 1770             


Gly Arg  Leu Ile Phe Ser Gly  Glu Ala Leu Thr Tyr  Lys Asp Ile 
    1775                 1780                 1785             


Val Val  Cys Met Asp Gly Asp  Thr Met Pro Gly Leu  Phe Ala Tyr 
    1790                 1795                 1800             


Lys Ala  Ala Thr Lys Ala Gly  Tyr Cys Gly Gly Ala  Val Leu Ala 
    1805                 1810                 1815             


Lys Asp  Gly Ala Glu Thr Phe  Ile Val Gly Thr His  Ser Ala Gly 
    1820                 1825                 1830             


Gly Asn  Gly Val Gly Tyr Cys  Ser Cys Val Ser Arg  Ser Met Leu 
    1835                 1840                 1845             


Leu Lys  Met Lys Ala His Ile  Asp Pro Glu Pro His  His Glu Gly 
    1850                 1855                 1860             


Leu Ile  Val Asp Thr Arg Asp  Val Glu Glu Arg Val  His Val Met 
    1865                 1870                 1875             


Arg Lys  Thr Lys Leu Ala Pro  Thr Val Ala His Gly  Val Phe Asn 
    1880                 1885                 1890             


Pro Glu  Phe Gly Pro Ala Ala  Leu Ser Asn Lys Asp  Pro Arg Leu 
    1895                 1900                 1905             


Asn Glu  Gly Val Val Leu Asp  Glu Ala Ile Phe Ser  Lys His Lys 
    1910                 1915                 1920             


Gly Asn  Thr Lys Met Ser Glu  Glu Asp Lys Ala Leu  Phe Arg Arg 
    1925                 1930                 1935             


Cys Ala  Ala Asp Tyr Ala Ser  Arg Leu His Ser Val  Leu Gly Thr 
    1940                 1945                 1950             


Ala Asn  Ala Pro Leu Ser Thr  Tyr Glu Ala Ile Lys  Gly Val Asp 
    1955                 1960                 1965             


Gly Leu  Asp Ala Met Glu Pro  Asp Thr Ala Pro Gly  Leu Pro Trp 
    1970                 1975                 1980             


Ala Leu  Gln Gly Lys Arg Arg  Gly Ala Leu Ile Asp  Phe Glu Asn 
    1985                 1990                 1995             


Gly Thr  Val Gly Pro Glu Val  Glu Ala Ala Leu Lys  Leu Met Glu 
    2000                 2005                 2010             


Lys Arg  Glu Tyr Lys Phe Val  Cys Gln Thr Phe Leu  Lys Asp Glu 
    2015                 2020                 2025             


Ile Arg  Pro Met Glu Lys Val  Arg Ala Gly Lys Thr  Arg Ile Val 
    2030                 2035                 2040             


Asp Val  Leu Pro Val Glu His  Ile Leu Tyr Thr Arg  Met Met Ile 
    2045                 2050                 2055             


Gly Arg  Phe Cys Ala Gln Met  His Leu Asn Asn Gly  Pro Gln Ile 
    2060                 2065                 2070             


Gly Ser  Ala Val Gly Cys Asn  Pro Asp Val Asp Trp  Gln Arg Phe 
    2075                 2080                 2085             


Gly Thr  His Phe Ala Gln Tyr  Arg Asn Val Trp Asp  Val Asp Tyr 
    2090                 2095                 2100             


Ser Ala  Phe Asp Ala Asn His  Cys Ser Asp Ala Met  Asn Ile Met 
    2105                 2110                 2115             


Phe Glu  Glu Val Phe Asn Thr  Asp Phe Gly Phe His  Pro Asn Ala 
    2120                 2125                 2130             


Glu Trp  Ile Leu Lys Thr Leu  Val Asn Thr Glu His  Ala Tyr Glu 
    2135                 2140                 2145             


Asn Lys  Arg Ile Thr Val Glu  Gly Gly Met Pro Ser  Gly Cys Ser 
    2150                 2155                 2160             


Ala Thr  Ser Ile Ile Asn Thr  Ile Leu Asn Asn Ile  Tyr Val Leu 
    2165                 2170                 2175             


Tyr Ala  Leu Arg Arg His Tyr  Glu Gly Val Glu Leu  Asp Ser Tyr 
    2180                 2185                 2190             


Thr Met  Ile Ser Tyr Gly Asp  Asp Ile Val Val Ala  Ser Asp Tyr 
    2195                 2200                 2205             


Asp Leu  Asp Phe Glu Ala Leu  Arg Pro His Phe Lys  Ser Leu Gly 
    2210                 2215                 2220             


Gln Thr  Ile Thr Pro Ala Asp  Lys Ser Asp Lys Gly  Phe Val Leu 
    2225                 2230                 2235             


Gly His  Ser Ile Thr Asp Val  Thr Phe Leu Lys Arg  His Phe His 
    2240                 2245                 2250             


Met Asp  Tyr Gly Thr Gly Phe  Tyr Lys Pro Val Met  Ala Ser Lys 
    2255                 2260                 2265             


Thr Leu  Glu Ala Ile Leu Ser  Phe Ala Arg Arg Gly  Thr Ile Gln 
    2270                 2275                 2280             


Glu Lys  Leu Ile Ser Val Ala  Gly Leu Ala Ile His  Ser Gly Pro 
    2285                 2290                 2295             


Asp Glu  Tyr Arg Arg Leu Phe  Glu Pro Phe Gln Gly  Leu Phe Glu 
    2300                 2305                 2310             


Ile Pro  Ser Tyr Arg Ser Leu  Tyr Leu Arg Trp Val  Asn Ala Val 
    2315                 2320                 2325             


Cys Gly  Asp Ala 
    2330         


<210>  108
<211>  2332
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(2332)
<223>  GenBank: ABR19839.1

<220>
<221>  MISC_FEATURE
<222>  (268)..(268)
<223>  Xaa may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (360)..(360)
<223>  Xaa may be any amino acid

<400>  108

Met Asn Thr Thr Asp Cys Phe Thr Ala Leu Ile His Ile Phe Arg Glu 
1               5                   10                  15      


Ile Arg Thr Leu Phe Leu Ser Arg Thr Gln Gly Lys Met Glu Phe Thr 
            20                  25                  30          


Leu Tyr Asn Gly Glu Lys Lys Thr Phe Tyr Ser Arg Pro Asn Asn His 
        35                  40                  45              


Asp Asn Cys Trp Leu Asn Ala Ile Leu Gln Leu Phe Arg Tyr Val Asp 
    50                  55                  60                  


Glu Pro Phe Phe Asp Trp Val Tyr Asp Ser Pro Glu Asn Leu Thr Val 
65                  70                  75                  80  


Glu Ala Ile Arg Gln Leu Glu Gly Leu Thr Gly Leu Glu Leu His Glu 
                85                  90                  95      


Gly Gly Pro Pro Ala Leu Val Ile Trp Asn Ile Lys His Leu Leu His 
            100                 105                 110         


Thr Gly Ile Gly Thr Ala Ser Arg Pro Ser Glu Val Cys Met Val Asp 
        115                 120                 125             


Gly Thr Asp Met Cys Leu Ala Asp Phe His Ala Gly Ile Phe Leu Lys 
    130                 135                 140                 


Gly Gln Glu His Ala Val Phe Ala Cys Val Thr Ser Asp Gly Trp Phe 
145                 150                 155                 160 


Ala Ile Asp Asp Glu Asp Phe Tyr Pro Trp Thr Pro Asp Pro Ser Asp 
                165                 170                 175     


Val Leu Val Phe Val Pro Tyr Asp Gln Glu Pro Leu Asn Gly Asp Trp 
            180                 185                 190         


Lys Ala Lys Val Gln Arg Arg Leu Lys Gly Ala Gly Gln Ser Ser Pro 
        195                 200                 205             


Ala Thr Trp Ser Gln Asn Gln Ser Gly Asn Thr Gly Ser Ile Ile Asn 
    210                 215                 220                 


Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser Met Asp Thr Gln Leu Gly 
225                 230                 235                 240 


Asp Asn Ala Thr Ser Gly Gly Ser Asn Glu Gly Ser Thr Asp Thr Thr 
                245                 250                 255     


Ser Thr His Thr Thr Asn Thr Gln Asn Asn Asp Xaa Phe Ser Lys Leu 
            260                 265                 270         


Ala Ser Ser Ala Phe Ser Gly Leu Phe Gly Ala Leu Leu Ala Asp Lys 
        275                 280                 285             


Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile Leu Thr Thr Arg 
    290                 295                 300                 


Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val Gly Val Thr Tyr 
305                 310                 315                 320 


Gly Tyr Ala Thr Ala Glu Asp Phe Val Ser Gly Pro Asn Thr Ser Gly 
                325                 330                 335     


Leu Glu Thr Arg Val Ala Gln Ala Glu Arg Phe Phe Lys Thr His Leu 
            340                 345                 350         


Phe Asp Trp Val Thr Ser Asp Xaa Phe Gly Arg Cys His Leu Leu Glu 
        355                 360                 365             


Leu Pro Thr Asp His Lys Gly Ile Tyr Gly Gly Leu Ile Asp Ser Tyr 
    370                 375                 380                 


Ala Tyr Met Arg Asn Gly Trp Asp Val Glu Val Thr Ala Val Gly Asn 
385                 390                 395                 400 


Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Met Val Pro Glu Leu Cys 
                405                 410                 415     


Ser Ile Gln Lys Arg Glu Leu Tyr Gln Leu Thr Leu Phe Pro His Gln 
            420                 425                 430         


Phe Ile Asn Pro Arg Thr Asn Met Thr Ala His Ile Thr Val Pro Phe 
        435                 440                 445             


Val Gly Val Asn Arg Tyr Asp Gln Tyr Lys Val His Lys Pro Trp Thr 
    450                 455                 460                 


Leu Val Val Met Val Val Ala Pro Leu Thr Val Asn Thr Glu Gly Ala 
465                 470                 475                 480 


Pro Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr Asn Val His Val 
                485                 490                 495     


Ala Gly Glu Phe Pro Ser Lys Glu Gly Ile Phe Pro Val Ala Cys Ser 
            500                 505                 510         


Asp Gly Tyr Gly Gly Leu Val Thr Thr Asp Pro Lys Thr Ala Asp Pro 
        515                 520                 525             


Ala Tyr Gly Lys Val Phe Asn Pro Pro Arg Asn Met Leu Pro Gly Arg 
    530                 535                 540                 


Phe Thr Asn Leu Leu Asp Val Ala Glu Ala Cys Pro Thr Phe Leu His 
545                 550                 555                 560 


Phe Glu Gly Asp Val Pro Tyr Val Thr Thr Lys Thr Asp Ser Asp Arg 
                565                 570                 575     


Val Leu Thr Gln Phe Asp Leu Ser Leu Ala Ala Lys His Met Ser Asn 
            580                 585                 590         


Thr Phe Leu Ala Gly Leu Ala Gln Tyr Tyr Thr Gln Tyr Ser Gly Thr 
        595                 600                 605             


Ile Asn Leu His Phe Met Phe Thr Gly Pro Thr Asp Ala Lys Ala Arg 
    610                 615                 620                 


Tyr Met Ile Ala Tyr Ala Pro Pro Gly Met Glu Pro Pro Lys Thr Pro 
625                 630                 635                 640 


Glu Thr Ala Ala His Cys Ile His Ala Glu Trp Asp Thr Gly Leu Asn 
                645                 650                 655     


Ser Lys Phe Thr Phe Ser Ile Pro Tyr Leu Ser Ala Ala Asp Tyr Ala 
            660                 665                 670         


Tyr Thr Ala Ser Ser Thr Ala Glu Thr Thr Asn Val Gln Gly Trp Val 
        675                 680                 685             


Cys Leu Phe Gln Ile Thr His Gly Lys Ala Asp Gly Asp Ala Leu Val 
    690                 695                 700                 


Val Leu Ala Ser Ala Gly Lys Asp Phe Asp Leu Arg Leu Pro Val Asp 
705                 710                 715                 720 


Ala Arg Thr Gln Thr Thr Ser Pro Gly Glu Ser Ala Asp Pro Val Thr 
                725                 730                 735     


Ala Thr Val Glu Asn Tyr Gly Gly Val Thr Gln Ala Gln Arg Arg Gln 
            740                 745                 750         


His Thr Asp Val Ser Phe Ile Leu Asp Arg Phe Val Lys Val Thr Pro 
        755                 760                 765             


Gln Asp Gln Ile Asn Val Leu Asp Leu Met Gln Ile Pro Ala His Thr 
    770                 775                 780                 


Leu Val Gly Ala Leu Leu Arg Thr Ser Thr Tyr Tyr Phe Ala Asp Leu 
785                 790                 795                 800 


Glu Leu Ala Val Lys His Glu Gly Asn Leu Thr Trp Val Pro Asn Gly 
                805                 810                 815     


Ala Pro Glu Ala Ala Leu Asp Asn Thr Thr Asn Pro Thr Val Tyr His 
            820                 825                 830         


Lys Ala Pro Leu Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg 
        835                 840                 845             


Val Leu Ala Thr Val Tyr Asn Gly Asn Cys Lys Tyr Ser Gly Ser Ser 
    850                 855                 860                 


Ala Thr Asn Val Arg Gly Asp Leu Gln Val Leu Ala Gln Arg Ala Ala 
865                 870                 875                 880 


Arg Thr Leu Pro Thr Ser Phe Asn Tyr Gly Ala Ile Lys Ala Thr Arg 
                885                 890                 895     


Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
            900                 905                 910         


Arg Pro Leu Leu Ala Ile His Pro Ser Glu Ala Arg His Lys Gln Lys 
        915                 920                 925             


Ile Val Ala Pro Val Lys Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu 
    930                 935                 940                 


Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Phe Phe Phe Ser Asp Val 
945                 950                 955                 960 


Arg Ser Asn Phe Ser Lys Leu Val Glu Thr Ile Asn Gln Met Gln Glu 
                965                 970                 975     


Asp Met Ser Thr Lys His Gly Pro Asp Phe Asn Arg Leu Val Ser Ala 
            980                 985                 990         


Phe Glu Glu Leu Ala Thr Gly Val  Lys Ala Ile Arg Thr  Gly Leu Asp 
        995                 1000                 1005             


Glu Ala  Lys Pro Trp Tyr Lys  Leu Ile Lys Leu Leu  Ser Arg Leu 
    1010                 1015                 1020             


Ser Cys  Met Ala Ala Val Ala  Ala Arg Ser Lys Asp  Pro Val Leu 
    1025                 1030                 1035             


Val Ala  Ile Met Leu Ala Asp  Thr Gly Leu Glu Ile  Leu Asp Ser 
    1040                 1045                 1050             


Thr Phe  Val Val Lys Lys Ile  Ser Asp Ser Leu Ser  Ser Leu Phe 
    1055                 1060                 1065             


His Val  Pro Ala Pro Ala Phe  Ser Phe Gly Ala Pro  Leu Leu Leu 
    1070                 1075                 1080             


Ala Gly  Leu Val Lys Val Ala  Ser Ser Phe Phe Arg  Ser Thr Pro 
    1085                 1090                 1095             


Glu Glu  Leu Glu Arg Ala Glu  Lys Gln Leu Lys Ala  Arg Asp Ile 
    1100                 1105                 1110             


Asn Asp  Ile Phe Ala Ile Leu  Lys Asn Gly Glu Trp  Leu Val Lys 
    1115                 1120                 1125             


Leu Ile  Leu Ala Ile Arg Asp  Trp Ile Lys Ala Trp  Ile Ala Ser 
    1130                 1135                 1140             


Glu Glu  Lys Phe Val Thr Met  Thr Asp Leu Val Pro  Gly Ile Leu 
    1145                 1150                 1155             


Glu Lys  Gln Arg Asp Leu Asn  Asp Pro Ser Lys Tyr  Lys Glu Ala 
    1160                 1165                 1170             


Lys Glu  Trp Leu Asp Asn Ala  Arg Gln Ala Cys Leu  Lys Ser Gly 
    1175                 1180                 1185             


Asn Val  His Ile Ala Asn Leu  Cys Lys Val Val Ala  Pro Ala Pro 
    1190                 1195                 1200             


Ser Arg  Ser Arg Pro Glu Pro  Val Val Val Cys Leu  Arg Gly Lys 
    1205                 1210                 1215             


Ser Gly  Gln Gly Lys Ser Phe  Leu Ala Asn Val Leu  Ala Gln Ala 
    1220                 1225                 1230             


Ile Ser  Thr His Phe Thr Gly  Arg Thr Asp Ser Val  Trp Tyr Cys 
    1235                 1240                 1245             


Pro Pro  Asp Pro Asp His Phe  Asp Gly Tyr Asn Gln  Gln Thr Val 
    1250                 1255                 1260             


Val Val  Met Asp Asp Leu Gly  Gln Asn Pro Asp Gly  Lys Asp Phe 
    1265                 1270                 1275             


Lys Tyr  Phe Ala Gln Met Val  Ser Thr Thr Gly Phe  Ile Pro Pro 
    1280                 1285                 1290             


Met Ala  Ser Leu Glu Asp Lys  Gly Lys Pro Phe Asn  Ser Lys Val 
    1295                 1300                 1305             


Ile Ile  Ala Thr Thr Asn Leu  Tyr Ser Gly Phe Thr  Pro Arg Thr 
    1310                 1315                 1320             


Met Val  Cys Pro Asp Ala Leu  Asn Arg Arg Phe His  Phe Asp Ile 
    1325                 1330                 1335             


Asp Val  Ser Ala Lys Asp Gly  Tyr Lys Ile Asn Asn  Lys Leu Asp 
    1340                 1345                 1350             


Ile Ile  Lys Ala Leu Glu Asp  Thr His Thr Asn Pro  Val Ala Met 
    1355                 1360                 1365             


Phe Gln  Tyr Asp Cys Ala Leu  Leu Asn Gly Met Ala  Val Glu Met 
    1370                 1375                 1380             


Lys Arg  Met Gln Gln Asp Met  Phe Lys Pro Gln Pro  Pro Leu Gln 
    1385                 1390                 1395             


Asn Val  Tyr Gln Leu Val Gln  Glu Val Ile Glu Arg  Val Glu Leu 
    1400                 1405                 1410             


His Glu  Lys Val Ser Asn His  Pro Ile Phe Lys Gln  Ile Ser Ile 
    1415                 1420                 1425             


Pro Ser  Gln Lys Ser Val Leu  Tyr Phe Leu Ile Glu  Lys Gly Gln 
    1430                 1435                 1440             


His Glu  Ala Ala Ile Glu Phe  Phe Glu Gly Met Val  His Asp Ser 
    1445                 1450                 1455             


Ile Lys  Glu Glu Leu Arg Pro  Leu Val Gln Gln Thr  Ser Phe Val 
    1460                 1465                 1470             


Lys Arg  Ala Phe Lys Arg Leu  Lys Glu Asn Phe Glu  Ile Val Ala 
    1475                 1480                 1485             


Leu Cys  Leu Thr Leu Leu Ala  Asn Ile Val Ile Met  Ile Arg Glu 
    1490                 1495                 1500             


Thr Arg  Lys Arg Gln Gln Met  Val Asp Asp Ala Val  Asn Glu Tyr 
    1505                 1510                 1515             


Ile Glu  Lys Ala Asn Ile Thr  Thr Asp Asp Lys Thr  Leu Asp Glu 
    1520                 1525                 1530             


Ala Glu  Lys Asn Pro Leu Glu  Thr Ser Gly Ala Ser  Thr Val Gly 
    1535                 1540                 1545             


Phe Arg  Glu Arg Thr Leu Pro  Gly Gln Lys Ala Ser  Asp Asp Val 
    1550                 1555                 1560             


Asn Ser  Glu Pro Ala Lys Pro  Val Asp Glu Gln Pro  Gln Ala Glu 
    1565                 1570                 1575             


Gly Pro  Tyr Ala Gly Pro Leu  Glu Arg Gln Lys Pro  Leu Lys Val 
    1580                 1585                 1590             


Arg Ala  Lys Leu Pro Gln Gln  Glu Gly Pro Tyr Ala  Gly Pro Met 
    1595                 1600                 1605             


Glu Arg  Gln Lys Pro Leu Lys  Val Lys Ala Lys Ala  Pro Val Val 
    1610                 1615                 1620             


Lys Glu  Gly Pro Tyr Glu Gly  Pro Val Lys Lys Pro  Val Ala Leu 
    1625                 1630                 1635             


Lys Val  Lys Ala Lys Asn Leu  Ile Val Thr Glu Ser  Gly Ala Pro 
    1640                 1645                 1650             


Pro Thr  Asp Leu Gln Lys Met  Val Met Gly Asn Thr  Lys Pro Val 
    1655                 1660                 1665             


Glu Leu  Ile Leu Asp Gly Lys  Thr Val Ala Ile Cys  Cys Ala Thr 
    1670                 1675                 1680             


Gly Val  Phe Gly Thr Ala Tyr  Leu Val Pro Arg His  Leu Phe Ala 
    1685                 1690                 1695             


Glu Lys  Tyr Asp Lys Ile Met  Leu Asp Gly Arg Ala  Met Thr Asp 
    1700                 1705                 1710             


Ser Asp  Tyr Arg Val Phe Glu  Phe Glu Ile Lys Val  Lys Gly Gln 
    1715                 1720                 1725             


Asp Met  Leu Ser Asp Ala Ala  Leu Met Val Leu His  Arg Gly Asn 
    1730                 1735                 1740             


Arg Val  Arg Asp Ile Thr Lys  His Phe Arg Asp Thr  Ala Arg Met 
    1745                 1750                 1755             


Lys Lys  Gly Thr Pro Val Val  Gly Val Ile Asn Asn  Ala Asp Val 
    1760                 1765                 1770             


Gly Arg  Leu Ile Phe Ser Gly  Glu Ala Leu Thr Tyr  Lys Asp Ile 
    1775                 1780                 1785             


Val Val  Cys Met Asp Gly Asp  Thr Met Pro Gly Leu  Phe Ala Tyr 
    1790                 1795                 1800             


Arg Ala  Ala Thr Lys Ala Gly  Tyr Cys Gly Gly Ala  Val Leu Ala 
    1805                 1810                 1815             


Lys Asp  Gly Ala Asp Thr Phe  Ile Val Gly Thr His  Ser Ala Gly 
    1820                 1825                 1830             


Gly Asn  Gly Val Gly Tyr Cys  Ser Cys Val Ser Arg  Ser Met Leu 
    1835                 1840                 1845             


Leu Lys  Met Lys Ala His Ile  Asp Pro Glu Pro His  His Glu Gly 
    1850                 1855                 1860             


Leu Ile  Ile Asp Thr Arg Asp  Val Glu Glu Arg Val  His Val Met 
    1865                 1870                 1875             


Arg Lys  Thr Lys Leu Ala Pro  Thr Val Ala His Gly  Val Phe Asn 
    1880                 1885                 1890             


Pro Glu  Phe Gly Pro Ala Ala  Leu Ser Asn Lys Asp  Pro Arg Leu 
    1895                 1900                 1905             


Asn Glu  Gly Val Val Leu Asp  Glu Val Ile Phe Ser  Lys His Lys 
    1910                 1915                 1920             


Gly Asp  Thr Lys Met Ser Glu  Glu Asp Lys Ala Leu  Phe Arg Arg 
    1925                 1930                 1935             


Cys Ala  Ala Asp Tyr Ala Ser  Arg Leu His Ser Glu  Leu Gly Thr 
    1940                 1945                 1950             


Ala Asn  Ala Pro Leu Ser Ile  Tyr Glu Ala Ile Lys  Gly Val Asp 
    1955                 1960                 1965             


Gly Leu  Asp Ala Met Glu Pro  Asp Thr Ala Pro Gly  Leu Pro Trp 
    1970                 1975                 1980             


Ala Leu  Gln Gly Lys Arg Arg  Gly Ala Leu Ile Asp  Phe Glu Asn 
    1985                 1990                 1995             


Gly Thr  Val Gly Pro Glu Val  Thr Ala Ala Leu Glu  Leu Met Glu 
    2000                 2005                 2010             


Lys Arg  Glu Tyr Lys Phe Ala  Cys Gln Thr Phe Leu  Lys Asp Glu 
    2015                 2020                 2025             


Ile Arg  Pro Met Glu Lys Val  Arg Ala Gly Lys Thr  Arg Ile Val 
    2030                 2035                 2040             


Asp Val  Leu Pro Val Glu His  Ile Leu Tyr Thr Arg  Met Met Ile 
    2045                 2050                 2055             


Gly Arg  Phe Cys Ala Gln Met  His Ala Asn Asn Gly  Pro Arg Ile 
    2060                 2065                 2070             


Gly Ser  Ala Val Gly Cys Asn  Pro Asp Val Asp Trp  Gln Arg Phe 
    2075                 2080                 2085             


Gly Thr  His Phe Ala Gln Tyr  Arg Asn Val Trp Asp  Val Asp Tyr 
    2090                 2095                 2100             


Ser Ala  Phe Asp Ala Asn His  Cys Ser Asp Ala Met  Asn Ile Met 
    2105                 2110                 2115             


Phe Glu  Glu Val Phe Arg Thr  Glu Phe Gly Phe His  Pro Asn Ala 
    2120                 2125                 2130             


Glu Trp  Ile Leu Lys Thr Leu  Val Asn Thr Glu His  Ala Tyr Glu 
    2135                 2140                 2145             


Asn Lys  Arg Ile Thr Val Glu  Gly Gly Met Pro Ser  Gly Cys Ser 
    2150                 2155                 2160             


Ala Thr  Ser Ile Ile Asn Thr  Ile Leu Asn Asn Ile  Tyr Val Leu 
    2165                 2170                 2175             


Tyr Ala  Leu Arg Arg His Tyr  Glu Gly Val Glu Leu  Asp Thr Tyr 
    2180                 2185                 2190             


Thr Met  Ile Ser Tyr Gly Asp  Asp Ile Val Val Ala  Ser Asp Tyr 
    2195                 2200                 2205             


Asp Leu  Asp Phe Glu Ala Leu  Lys Pro His Phe Lys  Ser Leu Gly 
    2210                 2215                 2220             


Gln Thr  Ile Thr Pro Ala Asp  Lys Ser Asp Lys Gly  Phe Val Leu 
    2225                 2230                 2235             


Gly His  Ser Ile Thr Asp Val  Thr Phe Leu Lys Arg  His Phe His 
    2240                 2245                 2250             


Met Asp  Tyr Gly Thr Gly Phe  Tyr Lys Pro Val Met  Ala Ser Lys 
    2255                 2260                 2265             


Thr Leu  Glu Ala Ile Leu Ser  Phe Ala Arg Arg Gly  Thr Ile Gln 
    2270                 2275                 2280             


Glu Lys  Leu Ile Ser Val Ala  Gly Leu Ala Val His  Ser Gly Pro 
    2285                 2290                 2295             


Asp Glu  Tyr Arg Arg Leu Phe  Glu Pro Phe Gln Gly  Leu Phe Glu 
    2300                 2305                 2310             


Ile Pro  Ser Tyr Arg Ser Leu  Tyr Leu Arg Trp Val  Asn Ala Val 
    2315                 2320                 2325             


Cys Gly  Asp Ala 
    2330         
