﻿SEQUENCE LISTING

<110>   Sagetis Biotech, SL

<120>   POLYPEPTIDES FOR BLOOD BRAIN BARRIER TRANSPORT

<130>   P062878WO

<140>   not yet assigned 
<141>   2013-11-14

<150>   GB 1220474.9 
<151>   2012-11-14

<160>   48

<170>   SeqWin2010, version 1.0

<210>   1
<211>   59
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Regulon 

<400>   1
His Lys Lys Trp Gln Phe Asn Ser Pro Phe Val Pro Arg Ala Asp Glu 
1               5                   10                  15      

Pro Ala Arg Lys Gly Lys Val His Ile Pro Phe Pro Leu Asp Asn Ile 
            20                  25                  30          

Thr Cys Arg Val Pro Met Ala Arg Glu Pro Thr Val Ile His Gly Lys 
        35                  40                  45              

Arg Glu Val Thr Leu His Leu His Pro Asp His 
    50                  55                  

<210>   2
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Regulon_construct1

<400>   2
Pro Thr Val Ile His Gly Lys Arg Glu Val Thr Leu His Leu 
1               5                   10                  

<210>   3
<211>   23
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Regulon_construct4

<400>   3
Pro Met Ala Arg Glu Pro Thr Val Ile His Gly Lys Arg Glu Val Thr 
1               5                   10                  15      

Leu His Leu His Pro Asp His 
            20              

<210>   4
<211>   20
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RH_construct1

<400>   4
Glu Leu Lys His Phe Glu Ala Lys Ile Glu Lys His Asn His Tyr Gln 
1               5                   10                  15      

Lys Gln Leu Glu 
            20  

<210>   5
<211>   41
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RH_construct2

<400>   5
Asp Lys Glu Leu Glu Ala Phe Arg Glu Glu Leu Lys His Phe Glu Ala 
1               5                   10                  15      

Lys Ile Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile Ala His 
            20                  25                  30          

Glu Lys Leu Arg His Ala Glu Ser Val 
        35                  40      

<210>   6
<211>   84
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RH_construct3

<400>   6
Asp Lys Glu Leu Glu Ala Phe Arg Glu Glu Leu Lys His Phe Glu Ala 
1               5                   10                  15      

Lys Ile Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile Ala His 
            20                  25                  30          

Glu Lys Leu Arg His Ala Glu Ser Val Gly Asp Gly Glu Arg Val Ser 
        35                  40                  45              

Arg Ser Arg Glu Lys His Ala Leu Leu Glu Gly Arg Thr Lys Glu Leu 
    50                  55                  60                  

Gly Tyr Thr Val Lys Lys His Leu Gln Asp Leu Ser Gly Arg Ile Ser 
65                  70                  75                  80  

Arg Ala Arg His 
                

<210>   7
<211>   19
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Flex_1

<400>   7
Thr Gly Glu Ser Asn Thr Val Arg Gly Lys Arg Gly Ser Tyr Lys Asp 
1               5                   10                  15      

Glu Asn Arg 
            

<210>   8
<211>   19
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Flex_2

<400>   8
Phe Arg Glu Ser Asn Thr Ile Arg Gly Lys Arg Glu Thr Thr Lys Asp 
1               5                   10                  15      

Glu Asn Arg 
            

<210>   9
<211>   19
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Flex_3

<400>   9
Thr Lys Glu Thr Ser Ala Thr Arg Gly Lys Arg Glu Thr Thr Lys Asp 
1               5                   10                  15      

Glu Gly Lys 
            

<210>   10
<211>   19
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Flex_4

<400>   10
Ala Arg Glu Thr Ser Ile Val Arg Gly Lys Arg Asp Tyr Phe Lys Asp 
1               5                   10                  15      

Glu Gly Lys 
            

<210>   11
<211>   19
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Flex_5

<400>   11
Ser Ser Glu Ser Asn Ile Thr Arg Gly Lys Arg Glu Tyr Thr Lys Asp 
1               5                   10                  15      

Glu Gly Arg 
            

<210>   12
<211>   20
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Rigid_1

<400>   12
Gly Asp Ala Ala Ala Ala Lys Ala Ala Lys Ala Ala Ala Lys Ala Ala 
1               5                   10                  15      

Ala Asp Gly Tyr 
            20  

<210>   13
<211>   20
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Rigid_2

<400>   13
Gly Asp Ala Ala Ala Ala Arg Ala Ala Lys Ala Ala Ala Arg Ala Ala 
1               5                   10                  15      

Ala Asp Gly Tyr 
            20  

<210>   14
<211>   34
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Rigid_3

<400>   14
Gly Asp Ala Ala Ala Ala Lys Ala Ala Lys Ala Ala Ala Lys Ala Ala 
1               5                   10                  15      

Ala Ala Ala Ala Lys Ala Ala Lys Ala Ala Ala Lys Ala Ala Ala Asp 
            20                  25                  30          

Gly Tyr 
        

<210>   15
<211>   34
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Rigid_4

<400>   15
Gly Asp Ala Ala Glu Ala Lys Ala Glu Lys Ala Glu Ala Lys Ala Glu 
1               5                   10                  15      

Ala Ala Glu Ala Lys Ala Glu Lys Ala Glu Ala Lys Ala Ala Ala Glu 
            20                  25                  30          

Gly Tyr 
        

<210>   16
<211>   34
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Rigid_5

<400>   16
Gly Asp Ala Ala Glu Ala Lys Ala Gln Lys Ala Gln Ala Lys Ala Asn 
1               5                   10                  15      

Ala Ala Lys Ala Lys Ala Gln Lys Ala Gln Ala Lys Ala Ala Ala Asn 
            20                  25                  30          

Gly Tyr 
        

<210>   17
<211>   6
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Linker

<400>   17
Gly Ser Gly Gly Gly Gly 
1               5       

<210>   18
<211>   8
<212>   PRT
<213>   Linker

<400>   18
Gly Ser Gly Ser Gly Gly Gly Gly 
1               5               

<210>   19
<211>   6
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Linker

<400>   19
Ala Ser Gly Gly Gly Ser 
1               5       

<210>   20
<211>   12
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Regulon hairpin

<400>   20
Thr Val Ile His Gly Lys Arg Glu Val Thr Leu His 
1               5                   10          

<210>   21
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Beta strand

<400>   21
Thr Val Ile His Gly 
1               5   

<210>   22
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Beta strand

<400>   22
Glu Val Thr Leu His 
1               5   

<210>   23
<211>   19
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is A, F, S or T

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is G, K, R or S

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   13
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   14
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   18
<223>   Xaa is G or N

<220>
<221>   misc_feature
<222>   19
<223>   Xaa is K or R

<400>   23
Xaa Xaa Glu Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp 
1               5                   10                  15      

Glu Xaa Xaa 
            

<210>   24
<211>   10
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is F, T or Y

<400>   24
Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu 
1               5                   10  

<210>   25
<211>   18
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is G, K, R or S

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   13
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   17
<223>   Xaa is G or N

<220>
<221>   misc_feature
<222>   18
<223>   Xaa is K or R

<400>   25
Xaa Glu Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu 
1               5                   10                  15      

Xaa Xaa 
        

<210>   26
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   10
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   16
<223>   Xaa is G or N

<220>
<221>   misc_feature
<222>   17
<223>   Xaa is K or R

<400>   26
Glu Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa 
1               5                   10                  15      

Xaa 
    

<210>   27
<211>   16
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   9
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   10
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   15
<223>   Xaa is G or N

<220>
<221>   misc_feature
<222>   16
<223>   Xaa is K or R

<400>   27
Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa Xaa 
1               5                   10                  15      

<210>   28
<211>   15
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   8
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   9
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   10
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   14
<223>   Xaa is G or N

<220>
<221>   misc_feature
<222>   15
<223>   Xaa is K or R

<400>   28
Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa Xaa 
1               5                   10                  15  

<210>   29
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   8
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   9
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   13
<223>   Xaa is G or N

<220>
<221>   misc_feature
<222>   14
<223>   Xaa is K or R

<400>   29
Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa Xaa 
1               5                   10                  

<210>   30
<211>   13
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   8
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is G or N

<220>
<221>   misc_feature
<222>   13
<223>   Xaa is K or R

<400>   30
Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa Xaa 
1               5                   10              

<210>   31
<211>   12
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is G or N

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is K or R

<400>   31
Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa Xaa 
1               5                   10          


<210>   32
<211>   18
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is A, F, S or T

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is G, K, R or S

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   13
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   14
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   18
<223>   Xaa is G or N


<400>   32
Xaa Xaa Glu Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp 
1               5                   10                  15      

Glu Xaa 


<210>   33
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is G, K, R or S

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   13
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   17
<223>   Xaa is G or N

<400>   33
Xaa Glu Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu 
1               5                   10                  15      

Xaa 
        

<210>   34
<211>   16
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   10
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   16
<223>   Xaa is G or N

<400>   34
Glu Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa 
1               5                   10                  15      

    

<210>   35
<211>   15
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   9
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   10
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   15
<223>   Xaa is G or N

<400>   35
Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa 
1               5                   10                  15      

<210>   36
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   8
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   9
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   10
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   14
<223>   Xaa is G or N

<400>   36
Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa 
1               5                   10                  

<210>   37
<211>   13
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   8
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   9
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   13
<223>   Xaa is G or N

<400>   37
Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa  
1               5                   10                  

<210>   38
<211>   12
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   8
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is G or N

<400>   38
Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa 
1               5                   10              

<210>   39
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is F, T or Y

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is G or N

<400>   39
Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu Xaa 
1               5                   10         


<210>   40
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is A, F, S or T

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is G, K, R or S

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   13
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   14
<223>   Xaa is F, T or Y



<400>   40
Xaa Xaa Glu Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp 
1               5                   10                  15      

Glu 


<210>   41
<211>   16
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is G, K, R or S

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   13
<223>   Xaa is F, T or Y

<400>   41
Xaa Glu Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu 
1               5                   10                  15      
        

<210>   42
<211>   15
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   10
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   12
<223>   Xaa is F, T or Y


<400>   42
Glu Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu 
1               5                   10                  15      

    
<210>   43
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is S or T

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   4
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   9
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   10
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   11
<223>   Xaa is F, T or Y

<400>   43
Xaa Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu 
1               5                   10                       

<210>   44
<211>   13
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is N or S

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   3
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   8
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   9
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   10
<223>   Xaa is F, T or Y

<400>   44
Xaa Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu 
1               5                   10                  

<210>   45
<211>   12
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is A, I or T

<220>
<221>   misc_feature
<222>   2
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   8
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   9
<223>   Xaa is F, T or Y

<400>   45
Xaa Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu 
1               5                   10                  

<210>   46
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   1
<223>   Xaa is I, T or V

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   8
<223>   Xaa is F, T or Y

<400>   46
Xaa Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu 
1               5                   10              

<210>   47
<211>   10
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Consensus sequence

<220>
<221>   misc_feature
<222>   5
<223>   Xaa is D, E or G

<220>
<221>   misc_feature
<222>   6
<223>   Xaa is S, T or Y

<220>
<221>   misc_feature
<222>   7
<223>   Xaa is F, T or Y

<400>   47
Arg Gly Lys Arg Xaa Xaa Xaa Lys Asp Glu 
1               5                   10  


<210>   48
<211>   357
<212>   PRT
<213>   Receptor associted protein

<400>   1
Met Ala Pro Arg Arg Val Arg Ser Phe Leu Arg Gly Leu Pro Ala Leu 
1               5                   10                  15      

Leu Leu Leu Leu Leu Phe Leu Gly Pro Trp Pro Ala Ala Ser His Gly 
            20                  25                  30          

Gly Lys Tyr Ser Arg Glu Lys Asn Gln Pro Lys Pro Ser Pro Lys Arg 
        35                  40                  45              

Glu Ser Gly Glu Glu Phe Arg Met Glu Lys Leu Asn Gln Leu Trp Glu 
    50                  55                  60                  

Lys Ala Gln Arg Leu His Leu Pro Pro Val Arg Leu Ala Glu Leu His 
65                  70                  75                  80  

Ala Asp Leu Lys Ile Gln Glu Arg Asp Glu Leu Ala Trp Lys Lys Leu 
                85                  90                  95      

Lys Leu Asp Gly Leu Asp Glu Asp Gly Glu Lys Glu Ala Arg Leu Ile 
            100                 105                 110         

Arg Asn Leu Asn Val Ile Leu Ala Lys Tyr Gly Leu Asp Gly Lys Lys 
        115                 120                 125             

Asp Ala Arg Gln Val Thr Ser Asn Ser Leu Ser Gly Thr Gln Glu Asp 
    130                 135                 140                 

Gly Leu Asp Asp Pro Arg Leu Glu Lys Leu Trp His Lys Ala Lys Thr 
145                 150                 155                 160 

Ser Gly Lys Phe Ser Gly Glu Glu Leu Asp Lys Leu Trp Arg Glu Phe 
                165                 170                 175     

Leu His His Lys Glu Lys Val His Glu Tyr Asn Val Leu Leu Glu Thr 
            180                 185                 190         

Leu Ser Arg Thr Glu Glu Ile His Glu Asn Val Ile Ser Pro Ser Asp 
        195                 200                 205             

Leu Ser Asp Ile Lys Gly Ser Val Leu His Ser Arg His Thr Glu Leu 
    210                 215                 220                 

Lys Glu Lys Leu Arg Ser Ile Asn Gln Gly Leu Asp Arg Leu Arg Arg 
225                 230                 235                 240 

Val Ser His Gln Gly Tyr Ser Thr Glu Ala Glu Phe Glu Glu Pro Arg 
                245                 250                 255     

Val Ile Asp Leu Trp Asp Leu Ala Gln Ser Ala Asn Leu Thr Asp Lys 
            260                 265                 270         

Glu Leu Glu Ala Phe Arg Glu Glu Leu Lys His Phe Glu Ala Lys Ile 
        275                 280                 285             

Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile Ala His Glu Lys 
    290                 295                 300                 

Leu Arg His Ala Glu Ser Val Gly Asp Gly Glu Arg Val Ser Arg Ser 
305                 310                 315                 320 

Arg Glu Lys His Ala Leu Leu Glu Gly Arg Thr Lys Glu Leu Gly Tyr 
                325                 330                 335     

Thr Val Lys Lys His Leu Gln Asp Leu Ser Gly Arg Ile Ser Arg Ala 
            340                 345                 350         

Arg His Asn Glu Leu 
        355        