                         SEQUENCE LISTING

<110>  Baliopharm AG
 
<120>  RECOMBINANT BISPECIFIC ANTIBODY

<130>  BA003P

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  VL Sequence

<400>  1

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Val Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Thr 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  2
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  2

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln 
1               5                   10                  15  


<210>  3
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  3

Val Ala Ser Asn Val Glu Ser 
1               5           


<210>  4
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  4

Gln Gln Ser Thr Lys Val Pro Trp Thr 
1               5                   


<210>  5
<211>  115
<212>  PRT
<213>  artificial

<220>
<223>  VH Sequence

<400>  5

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Thr Asp Gly Tyr Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  6
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  6

Thr Asn Ala Met Asn 
1               5   


<210>  7
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  7

Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  8
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  8

Asp Gly Tyr Tyr 
1               


<210>  9
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  VL Sequence

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Val Ala Ser Asn Val Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln Ser Thr 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  10
<211>  115
<212>  PRT
<213>  artificial

<220>
<223>  VH Sequence

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Thr Asp Gly Tyr Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  11
<211>  106
<212>  PRT
<213>  artificial

<220>
<223>  VL Sequence

<400>  11

Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  12
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  12

Arg Ala Ser Ser Ser Val Ser Tyr Met 
1               5                   


<210>  13
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  13

Ala Pro Ser Asn Leu Ala Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  14

Gln Gln Trp Ser Phe Asn Pro Pro Thr 
1               5                   


<210>  15
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  VH Sequence

<400>  15

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  16
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  16

Ser Tyr Asn Met His 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  17

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  CDR Sequence

<400>  18

Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  19
<211>  106
<212>  PRT
<213>  artificial

<220>
<223>  VL Sequence

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  20
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  VH Sequence

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  21
<211>  218
<212>  PRT
<213>  artificial

<220>
<223>  LC Sequence

<400>  21

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Val Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Thr 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  22
<211>  657
<212>  DNA
<213>  artificial

<220>
<223>  LC Sequence

<400>  22
gacattgtgc tcacccaatc tccagcttct ttggctgtgt ctctagggca gagagccacc       60

atctcctgca gagccagtga aagtgttgaa tattatggca caagtttaat gcaatggtac      120

caacagaagc caggacagcc acccaaactc ctcatctatg ttgcatccaa cgtagaatct      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccac      240

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaagtacgaa ggttccttgg      300

acgttcggtg gaggcaccaa gctggaaatc aaacggactg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttag         657


<210>  23
<211>  585
<212>  PRT
<213>  artificial

<220>
<223>  HC Sequence

<400>  23

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Thr Asp Gly Tyr Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser 
    210                 215                 220                 


Pro Pro Ser Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Ser Gly Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu 
            340                 345                 350         


Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        355                 360                 365             


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg 
    370                 375                 380                 


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
385                 390                 395                 400 


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            420                 425                 430         


Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr 
        435                 440                 445             


Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
465                 470                 475                 480 


Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
                485                 490                 495     


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His 
            500                 505                 510         


Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
        515                 520                 525             


Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    530                 535                 540                 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
545                 550                 555                 560 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
                565                 570                 575     


Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            580                 585 


<210>  24
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Linker

<400>  24

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  25
<211>  1095
<212>  DNA
<213>  artificial

<220>
<223>  HC Sequence

<400>  25
gaggtgcagc ttgttgagac tggtggagga ttggtgcagc ctaaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat accaatgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtaataa ttatgcaaca      180

tactatgccg aatcagtgaa agacaggttc accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cttgaaagct gaggacacag ccatgtatta ctgtgtgact      300

gatggttact actggggcca aggcaccact ctcacagtct cctcagggca gccctccgga      360

caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg      420

tcctgcaagg cttctggcta cacatttacc agttacaata tgcactgggt aaagcagaca      480

cctagacagg gcctggaatg gattggagct atttatccag gaaatggtga tacttcctac      540

aatcagaagt tcaagggcaa ggccacactg actgtagaca aatcctccag cacagcctac      600

atgcagctca gcagcctgac ctctgaagac tctgcggtct atttctgtgc aagagtggtg      660

tactatagta actcttactg gtacttcgac gtctggggca cagggaccac ggtcaccgtc      720

tcctcaggtg gaggcggttc aggcggaggt ggctctggcg gtggcggatc ggacatcgtt      780

ctctcccagt ctccagctat cttgtctgca tctccagggg agaaggtcac catgacttgc      840

agagccagtt caagtgttag ttacatgcac tggtaccagc agaagccagg atcctccccc      900

aaaccctgga tttatgcccc atccaacctg gcttctggag tccctgctcg cttcagtggc      960

agtgggtctg ggacctctta ctctctcaca atcagcagag tggaggctga agatgctgcc     1020

acttattact gccagcagtg gagttttaac ccacccacgt tcggtgctgg gaccaagctg     1080

gagctgaaat gataa                                                      1095


<210>  26
<211>  218
<212>  PRT
<213>  artificial

<220>
<223>  LC Sequence

<400>  26

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Val Ala Ser Asn Val Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln Ser Thr 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  27
<211>  717
<212>  DNA
<213>  artificial

<220>
<223>  LC Sequence

<400>  27
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg ctccaccggc       60

gacatcgtga tgacccagtc ccccgactcc ctggccgtgt ccctgggcga gagggccacc      120

atctcctgca gggcctccga gtccgtggag tactacggca cctccctgat gcagtggtac      180

cagcagaagc ccggccagcc ccccaagctg ctgatctacg tggcctccaa cgtggagtcc      240

ggcgtgcccg acaggttctc cggctccggc tccggcaccg acttcaccct gaccatctcc      300

tccctgcagg ccgaggacgt ggccgtgtac ttctgccagc agtccaccaa ggtgccctgg      360

accttcggcc agggcaccaa gctggagatc aagcgtacgg tggccgcccc ctccgtgttc      420

atcttccccc cctccgacga gcagctgaag tccggcaccg cctccgtggt gtgcctgctg      480

aacaacttct accccaggga ggccaaggtg cagtggaagg tggacaacgc cctgcagtcc      540

ggcaactccc aggagtccgt gaccgagcag gactccaagg actccaccta ctccctgtcc      600

tccaccctga ccctgtccaa ggccgactac gagaagcaca aggtctacgc ctgcgaggtg      660

acccaccagg gcctgtcctc ccccgtgacc aagtccttca acaggggcga gtgctga         717


<210>  28
<211>  585
<212>  PRT
<213>  artificial

<220>
<223>  HC Sequence

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Thr Asp Gly Tyr Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser 
    210                 215                 220                 


Pro Pro Ser Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Ser Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            340                 345                 350         


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        355                 360                 365             


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly 
    370                 375                 380                 


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
385                 390                 395                 400 


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Arg Asp Thr 
                405                 410                 415     


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            420                 425                 430         


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr 
        435                 440                 445             


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
465                 470                 475                 480 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                485                 490                 495     


Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His 
            500                 505                 510         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Ala 
        515                 520                 525             


Pro Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    530                 535                 540                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
545                 550                 555                 560 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
                565                 570                 575     


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            580                 585 


<210>  29
<211>  1818
<212>  DNA
<213>  artificial

<220>
<223>  HC Sequence

<400>  29
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg ctccaccggc       60

gaggtgcagc tggtggagtc cggcggcggc ctggtgaagc ccggcggctc cctgaggctg      120

tcctgcgccg cctccggctt caccttcaac accaacgcca tgaactgggt gaggcaggcc      180

cccggcaagg gcctggagtg ggtggccagg atcaggtcca agtccaacaa ctacgccacc      240

tactacgccg agtccgtgaa ggacaggttc accatctcca gggacgactc caagaacacc      300

ctgtacctgc agatgaactc cctgaagacc gaggacaccg ccgtgtacta ctgcgtgacc      360

gacggctact actggggcca gggcaccacc ctgaccgtgt cctccgcctc caccaagggc      420

ccctccgtgt tccccctggc cccctcctcc aagtccacct ccggcggcac cgccgccctg      480

ggctgcctgg tgaaggacta cttccccgag cccgtgaccg tgtcctggaa ctccggcgcc      540

ctgacctccg gcgtgcacac cttccccgcc gtgctgcagt cctccggcct gtactccctg      600

tcctccgtgg tgaccgtgcc ctcctcctcc ctgggcaccc agacctacat ctgcaacgtg      660

aaccacaagc cctccaacac caaggtggac aagaaggtgg agcccaagtc ctgcgacaag      720

acccacacct cccccccctc ccccgccccc cccgtggccg gcccctccgt gttcctgttc      780

ccccccaagc ccaaggacac cctgatgatc tccaggaccc ccgaggtgac ctgcgtggtg      840

gtgggcgtgt cccacgagga ccccgaggtg aagttcaact ggtacgtgga cggcgtggag      900

gtgcacaacg ccaagaccaa gcccagggag gagcagtacc agtccaccta cagggtggtg      960

tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtg     1020

tccaacaagc agctgccctc ccccatcgag aagacgatat ccaaggccaa gggccagccc     1080

tccggccagg tgcagctggt gcagtccggc gccgaggtga agaagcccgg cgcctccgtg     1140

aaggtgtcct gcaaggcctc cggctacacc ttcacctcct acaacatgca ctgggtcagg     1200

caggcccccg gccagggcct ggagtggatc ggcgccatct accccggcaa cggcgacacc     1260

tcctacaacc agaagttcaa gggcagggtg accatcacca gggacacctc cgcctccacc     1320

gcctacatgg agctgtcctc cctgaggtcc gaggacaccg ccgtgtacta ctgcgccagg     1380

gtggtgtact actccaactc ctactggtac ttcgacgtgt ggggccaggg caccctggtg     1440

accgtgtcct ccggcggcgg cggctccggc ggcggcggat ccggcggcgg cggctccgac     1500

atccagatga cccagtcccc ctcctccctg tccgcctccg tgggcgacag ggtgaccatc     1560

acctgcaggg cctcctcctc cgtgtcctac atgcactggt accagcagaa gcccggcaag     1620

gcccccaagc ccctgatcta cgccccctcc aacctggcct ccggcgtgcc ctccaggttc     1680

tccggctccg gctccggcac cgacttcacc ctgaccatct cctccctgca gcccgaggac     1740

ttcgccacct actactgcca gcagtggtcc ttcaaccccc ccaccttcgg ccagggcacc     1800

aagctggaga tcaagtga                                                   1818


