                         SEQUENCE LISTING

<110>  Novozymes A/S
       Christensen, Bjarke
       Olsen, Peter
 
<120>  Isopropanol Production by Recombinant Hosts Using an HMG-CoA 
       Intermediate

<130>  12550-WO-PCT

<150>  US 61/727,876
<151>  2012-11-19

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  1179
<212>  DNA
<213>  C. acetobutylicum

<400>  1
atgaaagaag ttgtaatagc tagtgcagta agaacagcga ttggatctta tggaaagtct       60

cttaaggatg taccagcagt agatttagga gctacagcta taaaggaagc agttaaaaaa      120

gcaggaataa aaccagagga tgttaatgaa gtcattttag gaaatgttct tcaagcaggt      180

ttaggacaga atccagcaag acaggcatct tttaaagcag gattaccagt tgaaattcca      240

gctatgacta ttaataaggt ttgtggttca ggacttagaa cagttagctt agcagcacaa      300

attataaaag caggagatgc tgacgtaata atagcaggtg gtatggaaaa tatgtctaga      360

gctccttact tagcgaataa cgctagatgg ggatatagaa tgggaaacgc taaatttgtt      420

gatgaaatga tcactgacgg attgtgggat gcatttaatg attaccacat gggaataaca      480

gcagaaaaca tagctgagag atggaacatt tcaagagaag aacaagatga gtttgctctt      540

gcatcacaaa aaaaagctga agaagctata aaatcaggtc aatttaaaga tgaaatagtt      600

cctgtagtaa ttaaaggcag aaagggagaa actgtagttg atacagatga gcaccctaga      660

tttggatcaa ctatagaagg acttgcaaaa ttaaaacctg ccttcaaaaa agatggaaca      720

gttacagctg gtaatgcatc aggattaaat gactgtgcag cagtacttgt aatcatgagt      780

gcagaaaaag ctaaagagct tggagtaaaa ccacttgcta agatagtttc ttatggttca      840

gcaggagttg acccagcaat aatgggatat ggacctttct atgcaacaaa agcagctatt      900

gaaaaagcag gttggacagt tgatgaatta gatttaatag aatcaaatga agcttttgca      960

gctcaaagtt tagcagtagc aaaagattta aaatttgata tgaataaagt aaatgtaaat     1020

ggaggagcta ttgcccttgg tcatccaatt ggagcatcag gtgcaagaat actcgttact     1080

cttgtacacg caatgcaaaa aagagatgca aaaaaaggct tagcaacttt atgtataggt     1140

ggcggacaag gaacagcaat attgctagaa aagtgctag                            1179


<210>  2
<211>  1179
<212>  DNA
<213>  C. acetobutylicum

<400>  2
atgaaagagg tcgtcattgc atcggctgtg cgtactgcta ttggttcata cggtaagagt       60

ttgaaagacg taccagcggt cgacttaggc gcaactgcca tcaaagaagc agttaagaaa      120

gcagggatta agccggaaga cgttaacgaa gttattctgg ggaacgtctt gcaagccggt      180

cttggtcaaa atccagcgcg tcaggcatct ttcaaagcgg gtcttccagt agaaattcct      240

gccatgacca tcaacaaggt atgcggtagt ggcctccgta ccgtctctct agctgctcag      300

atcatcaaag cgggagacgc cgatgttatc attgctggtg gtatggaaaa catgagtcgg      360

gcaccctacc tagcaaacaa cgcacgttgg ggataccgta tgggtaacgc caaattcgtc      420

gatgaaatga ttactgacgg cctctgggac gcattcaacg actaccacat gggaatcact      480

gccgaaaaca ttgccgaacg ttggaacatt agtcgcgaag aacaagatga gttcgcgttg      540

gcgagccaaa agaaagctga agaagcaatc aaatcaggtc aattcaaaga tgaaattgtt      600

cctgtggtta tcaaaggtcg caaaggcgaa acggttgtcg acactgacga acatccgcgt      660

ttcggaagta cgatcgaagg actcgcgaag ttgaaacctg ccttcaagaa ggacggcacc      720

gtgacggctg gcaacgcaag cggcttaaac gactgcgcag ccgtcctcgt cattatgagt      780

gccgagaaag ccaaagaact gggtgtgaaa ccgctcgcca agattgttag ctacggctct      840

gctggtgttg acccagccat tatgggttat ggccctttct acgctactaa agccgctatt      900

gaaaaagccg gatggaccgt agacgaactt gacctgattg aatcgaacga ggctttcgct      960

gctcagtcct tagccgtagc aaaagacttg aagttcgaca tgaacaaagt taacgtaaac     1020

ggtggtgcca ttgctttggg acacccgatt ggtgcctcgg gtgctcggat cttagttacg     1080

ctggttcacg caatgcaaaa gcgtgacgct aagaaagggt tggcaacatt atgcatcggt     1140

ggtggacaag gcacagcgat ccttcttgaa aagtgctag                            1179


<210>  3
<211>  392
<212>  PRT
<213>  C. acetobutylicum

<400>  3

Met Lys Glu Val Val Ile Ala Ser Ala Val Arg Thr Ala Ile Gly Ser 
1               5                   10                  15      


Tyr Gly Lys Ser Leu Lys Asp Val Pro Ala Val Asp Leu Gly Ala Thr 
            20                  25                  30          


Ala Ile Lys Glu Ala Val Lys Lys Ala Gly Ile Lys Pro Glu Asp Val 
        35                  40                  45              


Asn Glu Val Ile Leu Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn 
    50                  55                  60                  


Pro Ala Arg Gln Ala Ser Phe Lys Ala Gly Leu Pro Val Glu Ile Pro 
65                  70                  75                  80  


Ala Met Thr Ile Asn Lys Val Cys Gly Ser Gly Leu Arg Thr Val Ser 
                85                  90                  95      


Leu Ala Ala Gln Ile Ile Lys Ala Gly Asp Ala Asp Val Ile Ile Ala 
            100                 105                 110         


Gly Gly Met Glu Asn Met Ser Arg Ala Pro Tyr Leu Ala Asn Asn Ala 
        115                 120                 125             


Arg Trp Gly Tyr Arg Met Gly Asn Ala Lys Phe Val Asp Glu Met Ile 
    130                 135                 140                 


Thr Asp Gly Leu Trp Asp Ala Phe Asn Asp Tyr His Met Gly Ile Thr 
145                 150                 155                 160 


Ala Glu Asn Ile Ala Glu Arg Trp Asn Ile Ser Arg Glu Glu Gln Asp 
                165                 170                 175     


Glu Phe Ala Leu Ala Ser Gln Lys Lys Ala Glu Glu Ala Ile Lys Ser 
            180                 185                 190         


Gly Gln Phe Lys Asp Glu Ile Val Pro Val Val Ile Lys Gly Arg Lys 
        195                 200                 205             


Gly Glu Thr Val Val Asp Thr Asp Glu His Pro Arg Phe Gly Ser Thr 
    210                 215                 220                 


Ile Glu Gly Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Thr 
225                 230                 235                 240 


Val Thr Ala Gly Asn Ala Ser Gly Leu Asn Asp Cys Ala Ala Val Leu 
                245                 250                 255     


Val Ile Met Ser Ala Glu Lys Ala Lys Glu Leu Gly Val Lys Pro Leu 
            260                 265                 270         


Ala Lys Ile Val Ser Tyr Gly Ser Ala Gly Val Asp Pro Ala Ile Met 
        275                 280                 285             


Gly Tyr Gly Pro Phe Tyr Ala Thr Lys Ala Ala Ile Glu Lys Ala Gly 
    290                 295                 300                 


Trp Thr Val Asp Glu Leu Asp Leu Ile Glu Ser Asn Glu Ala Phe Ala 
305                 310                 315                 320 


Ala Gln Ser Leu Ala Val Ala Lys Asp Leu Lys Phe Asp Met Asn Lys 
                325                 330                 335     


Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly Ala 
            340                 345                 350         


Ser Gly Ala Arg Ile Leu Val Thr Leu Val His Ala Met Gln Lys Arg 
        355                 360                 365             


Asp Ala Lys Lys Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln Gly 
    370                 375                 380                 


Thr Ala Ile Leu Leu Glu Lys Cys 
385                 390         


<210>  4
<211>  702
<212>  DNA
<213>  B. subtilis

<400>  4
atgggaaaag gaaaagtgat ggactcttat caagatgctg ctgcactgat caaggacgga       60

gacaccctca tcgcaggagg cttcggcctg tgcggcattc cggaacaatt aattctcgcg      120

atcagggaca gcggcgtaaa aaacttgacc gttgtcagta ataactgcgg tgttgatgat      180

tgggggttag gcctcttgct tgcaaaccgg cagatcaaaa aaatggtcgc atcctatgtg      240

ggagaaaaca aaacctttga acggcagttt ttaagcgggg agctggaagt cgaattggtg      300

ccccaaggaa cgctcgcaga aagaattcgc gcgggagggg cgggcattcc ggcgttttac      360

acacctgcgg gcgtcggaac atcagtagcc gagggaaaag aacataagac atttgacgga      420

cgcacctatc ttctggagaa agggattaca gggaacgccg ccatcgtaaa ggcctggaaa      480

gccgatcctc tgggcaacct gatgttcaga aagacggcga gaaatttcaa tccgctcgct      540

gcaatggcag gcaaagtgac gattgcagag gctgaagaaa tcgtcgatgc cggagagctt      600

gatccggatc aaattcatac gccgggtatt tttgtgcagc acgtgctgct cggcgggatt      660

catgaaaaac ggattgaacg ccgcaccgtc cggcaagcat ga                         702


<210>  5
<211>  702
<212>  DNA
<213>  B. subtilis

<400>  5
atgggtaagg gtaaagtaat ggattcttat caagatgcag cagcgttgat caaagatggt       60

gacaccttaa tcgcaggcgg ttttggcctt tgtggtattc ctgagcagtt aatccttgct      120

atccgtgaca gtggcgttaa gaacttgacc gttgtgtcca acaattgtgg ggttgatgat      180

tgggggttgg gtctgttgct cgccaatcgg cagatcaaga agatggtcgc ctcttatgtg      240

ggtgaaaaca aaacttttga acgccagttc ttaagcggtg aattagaagt tgaacttgtt      300

cctcaaggaa cgctggctga gcggattcgt gcaggtggtg cagggattcc tgccttctat      360

actcctgcgg gtgtgggtac aagcgtcgcg gaaggtaagg aacacaaaac ctttgatggt      420

cggacctatc ttttggaaaa aggtatcacc ggtaatgcag ccattgtgaa agcctggaaa      480

gccgacccac ttggtaatct tatgtttcgg aaaactgcac gcaacttcaa tccattagca      540

gcaatggctg gtaaagtgac cattgctgaa gccgaagaaa ttgtcgatgc tggtgaactt      600

gatccagatc agattcacac tccagggatt ttcgttcagc atgttttgct tggtggcatc      660

catgagaaac gtattgaacg tcgtacggtc cgtcaggcat ag                         702


<210>  6
<211>  233
<212>  PRT
<213>  B. subtilis

<400>  6

Met Gly Lys Gly Lys Val Met Asp Ser Tyr Gln Asp Ala Ala Ala Leu 
1               5                   10                  15      


Ile Lys Asp Gly Asp Thr Leu Ile Ala Gly Gly Phe Gly Leu Cys Gly 
            20                  25                  30          


Ile Pro Glu Gln Leu Ile Leu Ala Ile Arg Asp Ser Gly Val Lys Asn 
        35                  40                  45              


Leu Thr Val Val Ser Asn Asn Cys Gly Val Asp Asp Trp Gly Leu Gly 
    50                  55                  60                  


Leu Leu Leu Ala Asn Arg Gln Ile Lys Lys Met Val Ala Ser Tyr Val 
65                  70                  75                  80  


Gly Glu Asn Lys Thr Phe Glu Arg Gln Phe Leu Ser Gly Glu Leu Glu 
                85                  90                  95      


Val Glu Leu Val Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly 
            100                 105                 110         


Gly Ala Gly Ile Pro Ala Phe Tyr Thr Pro Ala Gly Val Gly Thr Ser 
        115                 120                 125             


Val Ala Glu Gly Lys Glu His Lys Thr Phe Asp Gly Arg Thr Tyr Leu 
    130                 135                 140                 


Leu Glu Lys Gly Ile Thr Gly Asn Ala Ala Ile Val Lys Ala Trp Lys 
145                 150                 155                 160 


Ala Asp Pro Leu Gly Asn Leu Met Phe Arg Lys Thr Ala Arg Asn Phe 
                165                 170                 175     


Asn Pro Leu Ala Ala Met Ala Gly Lys Val Thr Ile Ala Glu Ala Glu 
            180                 185                 190         


Glu Ile Val Asp Ala Gly Glu Leu Asp Pro Asp Gln Ile His Thr Pro 
        195                 200                 205             


Gly Ile Phe Val Gln His Val Leu Leu Gly Gly Ile His Glu Lys Arg 
    210                 215                 220                 


Ile Glu Arg Arg Thr Val Arg Gln Ala 
225                 230             


<210>  7
<211>  651
<212>  DNA
<213>  B. subtilis

<400>  7
gtgaaggaag cgagaaaacg aatggtcaaa cgggctgtac aagaaatcaa ggacggcatg       60

aatgtgaatc tcgggattgg aatgccgacg cttgtcgcaa atgagatacc cgatggcgtt      120

cacgtcatgc ttcagtcgga aaacggcttg ctcggaattg gcccctatcc tctggaagga      180

acggaagacg cggatttgat caatgcggga aaggaaacga tcactgaagt gacaggcgcc      240

tcttattttg acagcgctga gtcattcgcg atgataagag gcgggcatat cgatttagct      300

attctcggcg gaatggaggt ttcggagcag ggggatttgg ccaattggat gatcccgggc      360

aaaatggtaa aagggatggg cggcgccatg gatctcgtca acggggcgaa acgaatcgtt      420

gtcatcatgg agcacgtcaa taagcatggt gaatcaaagg tgaaaaaaac atgctccctt      480

ccgctgacag gccagaaagt cgtacacagg ctgattacgg atttggctgt atttgatttt      540

gtgaacggcc gcatgacact gacggagctt caggatggtg tcacaattga agaggtttat      600

gaaaaaacag aagctgattt cgctgtaagc cagtctgtac tcaattctta a               651


<210>  8
<211>  651
<212>  DNA
<213>  B. subtilis

<400>  8
atgaaggaag ctcgtaagcg tatggttaag cgtgcggttc aggaaatcaa agacggtatg       60

aacgttaact taggcatcgg gatgccgaca cttgttgcaa acgaaattcc ggacggtgta      120

cacgttatgt tacagagtga aaacggattg ttgggtattg gtccctaccc actcgaaggc      180

accgaagacg ctgacttgat caatgccgga aaggaaacga ttacggaagt gactggcgca      240

tcttacttcg acagtgcgga gtcgttcgcc atgattcgtg gtggacacat tgacctggct      300

atcctcggtg gaatggaggt gtctgaacag ggggacttag cgaactggat gattccaggc      360

aaaatggtca agggtatggg tggtgcaatg gacttggtca atggcgctaa acggatcgtc      420

gtgatcatgg aacacgttaa caagcacggt gaaagtaagg ttaagaagac atgctcctta      480

ccgttgacgg gacagaaggt ggttcaccgc ttgattaccg acctcgcagt tttcgacttc      540

gttaacggac gtatgactct tacggaacta caggacggtg tcacgatcga agaagtttac      600

gaaaagactg aagcagactt cgctgtgtcc cagagtgtgc tcaacagtta g               651


<210>  9
<211>  216
<212>  PRT
<213>  B. subtilis


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Xaa Lys Glu Ala Arg Lys Arg Met Val Lys Arg Ala Val Gln Glu Ile 
1               5                   10                  15      


Lys Asp Gly Met Asn Val Asn Leu Gly Ile Gly Met Pro Thr Leu Val 
            20                  25                  30          


Ala Asn Glu Ile Pro Asp Gly Val His Val Met Leu Gln Ser Glu Asn 
        35                  40                  45              


Gly Leu Leu Gly Ile Gly Pro Tyr Pro Leu Glu Gly Thr Glu Asp Ala 
    50                  55                  60                  


Asp Leu Ile Asn Ala Gly Lys Glu Thr Ile Thr Glu Val Thr Gly Ala 
65                  70                  75                  80  


Ser Tyr Phe Asp Ser Ala Glu Ser Phe Ala Met Ile Arg Gly Gly His 
                85                  90                  95      


Ile Asp Leu Ala Ile Leu Gly Gly Met Glu Val Ser Glu Gln Gly Asp 
            100                 105                 110         


Leu Ala Asn Trp Met Ile Pro Gly Lys Met Val Lys Gly Met Gly Gly 
        115                 120                 125             


Ala Met Asp Leu Val Asn Gly Ala Lys Arg Ile Val Val Ile Met Glu 
    130                 135                 140                 


His Val Asn Lys His Gly Glu Ser Lys Val Lys Lys Thr Cys Ser Leu 
145                 150                 155                 160 


Pro Leu Thr Gly Gln Lys Val Val His Arg Leu Ile Thr Asp Leu Ala 
                165                 170                 175     


Val Phe Asp Phe Val Asn Gly Arg Met Thr Leu Thr Glu Leu Gln Asp 
            180                 185                 190         


Gly Val Thr Ile Glu Glu Val Tyr Glu Lys Thr Glu Ala Asp Phe Ala 
        195                 200                 205             


Val Ser Gln Ser Val Leu Asn Ser 
    210                 215     


<210>  10
<211>  714
<212>  DNA
<213>  B. mojavensis

<400>  10
atgggaaaag tgctgtcatc gagtaaggaa gccgcggaac tcattcggga gggggataca       60

ctgatcgcgg gcggattcgg cctgtgcgga attcccgagc agctcattct ggcgataagg      120

gataaagggg taaaagattt aaccgtcgtc agcaataatt gcggagttga tgattggggg      180

ctcggtctgc tgctggcaaa caagcaaatc aaaaaaatga tcgcttccta cgtcggagaa      240

aacaaaattt ttgaaaagca atttttaagc ggagaattgg aagtggaatt ggttccccaa      300

gggaccctcg ctgaaagaat ccgagccgga ggagcgggta taccgggatt ttacacagcc      360

acaggcgtcg gaacatctat cgctgacggg aaagagcata aaacctttga cggacgcact      420

tatgtgttag aaaaagggat tactggggat gtcgccattg taaaagcatg gaaagcggac      480

accatgggga atttagtttt tcggaaaacg gcaagaaatt tcaatccggt tgccgccatg      540

gcgggaaaga tcacaattgc cgaggcagaa gaaattgttg aggcgggaga gctcgatccc      600

gaccacatac acacgcctgg tatttacgta cagcatgttg tgctcggcac acatgaaaag      660

cggattgaaa aacgaactgt tcagcaagcg gagggaaagg aggcggcaca atga            714


<210>  11
<211>  714
<212>  DNA
<213>  B. mojavensis

<400>  11
atggggaaag tactcagttc tagcaaagaa gctgcggagt taatccgtga gggcgataca       60

cttattgcgg gtggtttcgg cctctgcggt attccagaac agttgatttt ggccattcgg      120

gataaaggtg taaaggatct gacagttgtc agcaataact gtggggttga tgactggggg      180

ttgggtctct tgttagcgaa caaacagatc aagaaaatga ttgcttcgta tgtgggcgaa      240

aacaagatct ttgaaaagca gtttttgtca ggagagcttg aagtggaact tgtcccacaa      300

gggaccctag ccgaacggat tcgtgccggt ggcgctggta ttcctggctt ctatacagct      360

acaggagtag gaacatctat cgctgatggt aaagaacaca aaacgttcga tggtcgtacc      420

tatgtgctcg aaaagggtat tactggggac gtggccattg tgaaagcgtg gaaggctgat      480

acgatgggta atctagtgtt tcggaagact gcccgtaact tcaatcctgt tgctgcaatg      540

gcaggcaaga ttacgatcgc tgaagcggaa gaaatcgtag aagcgggtga attagatcct      600

gaccacattc atactccagg catctacgta cagcatgtag tattgggtac acatgaaaaa      660

cgtatcgaaa aacgcacggt acaacaggcc gaaggcaaag aagcagcgca atag            714


<210>  12
<211>  237
<212>  PRT
<213>  B. mojavensis

<400>  12

Met Gly Lys Val Leu Ser Ser Ser Lys Glu Ala Ala Glu Leu Ile Arg 
1               5                   10                  15      


Glu Gly Asp Thr Leu Ile Ala Gly Gly Phe Gly Leu Cys Gly Ile Pro 
            20                  25                  30          


Glu Gln Leu Ile Leu Ala Ile Arg Asp Lys Gly Val Lys Asp Leu Thr 
        35                  40                  45              


Val Val Ser Asn Asn Cys Gly Val Asp Asp Trp Gly Leu Gly Leu Leu 
    50                  55                  60                  


Leu Ala Asn Lys Gln Ile Lys Lys Met Ile Ala Ser Tyr Val Gly Glu 
65                  70                  75                  80  


Asn Lys Ile Phe Glu Lys Gln Phe Leu Ser Gly Glu Leu Glu Val Glu 
                85                  90                  95      


Leu Val Pro Gln Gly Thr Leu Ala Glu Arg Ile Arg Ala Gly Gly Ala 
            100                 105                 110         


Gly Ile Pro Gly Phe Tyr Thr Ala Thr Gly Val Gly Thr Ser Ile Ala 
        115                 120                 125             


Asp Gly Lys Glu His Lys Thr Phe Asp Gly Arg Thr Tyr Val Leu Glu 
    130                 135                 140                 


Lys Gly Ile Thr Gly Asp Val Ala Ile Val Lys Ala Trp Lys Ala Asp 
145                 150                 155                 160 


Thr Met Gly Asn Leu Val Phe Arg Lys Thr Ala Arg Asn Phe Asn Pro 
                165                 170                 175     


Val Ala Ala Met Ala Gly Lys Ile Thr Ile Ala Glu Ala Glu Glu Ile 
            180                 185                 190         


Val Glu Ala Gly Glu Leu Asp Pro Asp His Ile His Thr Pro Gly Ile 
        195                 200                 205             


Tyr Val Gln His Val Val Leu Gly Thr His Glu Lys Arg Ile Glu Lys 
    210                 215                 220                 


Arg Thr Val Gln Gln Ala Glu Gly Lys Glu Ala Ala Gln 
225                 230                 235         


<210>  13
<211>  657
<212>  DNA
<213>  B. mojavensis

<400>  13
atgaaggaag ccagaaaacg aatggtcaaa cgtgctgtaa aggaaataaa agacggtatg       60

aacgtcaatc ttgggatagg gatgccgaca cttgtggcaa atgaaatacc ggagggcgtt      120

catgtgatgc ttcaatcaga aaacggcttg cttgggatcg gcccgtatcc gctggacgga      180

acggaagacc cggatctgat caatgcgggg aaagaaacga tcaccgccgt aacaggcgca      240

tcctattttg acagcgcaga atcctttgcg atgatacgag gcggtcatat cgacctggct      300

atcctcgggg gcatggaggt ttctgagcaa ggggatttgg cgaactggat gatcccgggg      360

aaaatggtga agggaatggg cggcgctatg gatttggtca acggggctaa gcgaatcgtt      420

gtcatcatgg agcacgtcaa taaacatggg gaatcgaagg tgaaaaaaca atgctccctc      480

ccgctgacag gacagaaagt cgttcatcgg ctgatcactg atttagctgt ttttgatttt      540

gataacggcc atatgacact gactgagctc caggacggcg tcacgctgga agaggtatat      600

gagaaaactg aagctgactt cgccgtaagc cagtcagtca tccggcaaaa atcttaa         657


<210>  14
<211>  657
<212>  DNA
<213>  B. mojavensis

<400>  14
atgaaagaag cccgtaagcg catggttaag cgtgccgtaa aggaaatcaa ggacgggatg       60

aacgttaact tgggtattgg tatgccgaca cttgtagcaa acgaaattcc tgaaggtgtt      120

cacgtcatgc tccagagtga gaacggtctt ttaggtattg gtccctaccc attagacggc      180

acagaggacc cagacttgat taacgcaggt aaagaaacta tcaccgctgt aactggggca      240

agttacttcg actcagcaga atctttcgct atgattcgtg gtgggcacat cgacttggca      300

attcttggtg gtatggaagt ttcagaacag ggggacttgg ctaactggat gattccaggc      360

aaaatggtta aggggatggg aggagctatg gacttggtaa atggcgcaaa gcggattgtg      420

gtcattatgg aacacgttaa caagcacggt gaatcaaagg tcaagaaaca gtgctccctt      480

ccattgactg gtcagaaggt tgttcaccgt ttgatcaccg acctcgctgt attcgacttc      540

gacaacggac acatgacttt gaccgagtta caggacggtg taacactaga agaggtttac      600

gagaaaacag aagccgactt cgcagttagc cagagtgtta tccgtcagaa atcgtag         657


<210>  15
<211>  218
<212>  PRT
<213>  B. mojavensis

<400>  15

Met Lys Glu Ala Arg Lys Arg Met Val Lys Arg Ala Val Lys Glu Ile 
1               5                   10                  15      


Lys Asp Gly Met Asn Val Asn Leu Gly Ile Gly Met Pro Thr Leu Val 
            20                  25                  30          


Ala Asn Glu Ile Pro Glu Gly Val His Val Met Leu Gln Ser Glu Asn 
        35                  40                  45              


Gly Leu Leu Gly Ile Gly Pro Tyr Pro Leu Asp Gly Thr Glu Asp Pro 
    50                  55                  60                  


Asp Leu Ile Asn Ala Gly Lys Glu Thr Ile Thr Ala Val Thr Gly Ala 
65                  70                  75                  80  


Ser Tyr Phe Asp Ser Ala Glu Ser Phe Ala Met Ile Arg Gly Gly His 
                85                  90                  95      


Ile Asp Leu Ala Ile Leu Gly Gly Met Glu Val Ser Glu Gln Gly Asp 
            100                 105                 110         


Leu Ala Asn Trp Met Ile Pro Gly Lys Met Val Lys Gly Met Gly Gly 
        115                 120                 125             


Ala Met Asp Leu Val Asn Gly Ala Lys Arg Ile Val Val Ile Met Glu 
    130                 135                 140                 


His Val Asn Lys His Gly Glu Ser Lys Val Lys Lys Gln Cys Ser Leu 
145                 150                 155                 160 


Pro Leu Thr Gly Gln Lys Val Val His Arg Leu Ile Thr Asp Leu Ala 
                165                 170                 175     


Val Phe Asp Phe Asp Asn Gly His Met Thr Leu Thr Glu Leu Gln Asp 
            180                 185                 190         


Gly Val Thr Leu Glu Glu Val Tyr Glu Lys Thr Glu Ala Asp Phe Ala 
        195                 200                 205             


Val Ser Gln Ser Val Ile Arg Gln Lys Ser 
    210                 215             


<210>  16
<211>  741
<212>  DNA
<213>  C. beijerinckii

<400>  16
atgttagaaa gtgaagtatc taaacaaatt acaactccac ttgctgctcc agcgtttcct       60

agaggaccat ataggtttca caatagagaa tatctaaaca ttatttatcg aactgattta      120

gatgctcttc gaaaaatagt accagagcca cttgaattag atagagcata tgttagattt      180

gaaatgatgg ctatgcctga tacaaccgga ctaggctcat atacagaatg tggtcaagct      240

attccagtaa aatataatgg tgttaagggt gactacttgc atatgatgta tctagataat      300

gaacctgcta ttgctgttgg aagagaaagt agcgcttatc caaaaaagct tggctatcca      360

aagctatttg ttgattcaga tactttagtt gggacactta aatatggtac attaccagta      420

gctactgcaa caatgggata taagcacgag cctctagatc ttaaagaagc ctatgctcaa      480

attgcaagac ccaattttat gctaaaaatc attcaaggtt acgatggtaa gccaagaatt      540

tgtgaactaa tatgtgcaga aaatactgat ataactattc acggtgcttg gactggaagt      600

gcacgtctac aattatttag ccatgcacta gctcctcttg ctgatttacc tgtattagag      660

attgtatcag catctcatat cctcacagat ttaactcttg gaacacctaa ggttgtacat      720

gattatcttt cagtaaaata a                                                741


<210>  17
<211>  741
<212>  DNA
<213>  C. beijerinckii

<400>  17
atgctcgaaa gtgaagtttc taaacagatt actaccccat tagcggcacc agcatttccc       60

cgtggtccat accgtttcca caaccgtgag tacttgaaca tcatttaccg tacggactta      120

gacgctttgc gcaagatcgt tccagaaccg ctcgaacttg accgtgctta cgttcgtttc      180

gaaatgatgg caatgccaga cacgaccggt ctcggctcat acacggaatg tgggcaagcc      240

attcccgtga aatacaacgg tgttaaagga gactacttac acatgatgta cttggataac      300

gaacctgcaa ttgcagttgg tcgcgaatct tccgcgtacc ccaagaaact cggataccct      360

aaacttttcg ttgactcgga cacgttggta ggtacgttga aatacgggac actgccagtc      420

gccacagcca caatgggtta caaacacgaa cctcttgacc ttaaggaagc atacgcccaa      480

attgcgcgtc ccaacttcat gttgaagatc attcaggggt acgacggcaa accacggatt      540

tgcgaactta tctgcgcaga aaacaccgac attacaattc atggggcttg gacaggtagt      600

gctcgcctcc agttattcag tcacgcctta gccccactgg cagacttacc tgtacttgaa      660

atcgtatcag caagccacat ccttaccgac ttgactttgg gtacaccgaa agttgtacac      720

gactacctca gtgtcaagta g                                                741


<210>  18
<211>  246
<212>  PRT
<213>  C. beijerinckii

<400>  18

Met Leu Glu Ser Glu Val Ser Lys Gln Ile Thr Thr Pro Leu Ala Ala 
1               5                   10                  15      


Pro Ala Phe Pro Arg Gly Pro Tyr Arg Phe His Asn Arg Glu Tyr Leu 
            20                  25                  30          


Asn Ile Ile Tyr Arg Thr Asp Leu Asp Ala Leu Arg Lys Ile Val Pro 
        35                  40                  45              


Glu Pro Leu Glu Leu Asp Arg Ala Tyr Val Arg Phe Glu Met Met Ala 
    50                  55                  60                  


Met Pro Asp Thr Thr Gly Leu Gly Ser Tyr Thr Glu Cys Gly Gln Ala 
65                  70                  75                  80  


Ile Pro Val Lys Tyr Asn Gly Val Lys Gly Asp Tyr Leu His Met Met 
                85                  90                  95      


Tyr Leu Asp Asn Glu Pro Ala Ile Ala Val Gly Arg Glu Ser Ser Ala 
            100                 105                 110         


Tyr Pro Lys Lys Leu Gly Tyr Pro Lys Leu Phe Val Asp Ser Asp Thr 
        115                 120                 125             


Leu Val Gly Thr Leu Lys Tyr Gly Thr Leu Pro Val Ala Thr Ala Thr 
    130                 135                 140                 


Met Gly Tyr Lys His Glu Pro Leu Asp Leu Lys Glu Ala Tyr Ala Gln 
145                 150                 155                 160 


Ile Ala Arg Pro Asn Phe Met Leu Lys Ile Ile Gln Gly Tyr Asp Gly 
                165                 170                 175     


Lys Pro Arg Ile Cys Glu Leu Ile Cys Ala Glu Asn Thr Asp Ile Thr 
            180                 185                 190         


Ile His Gly Ala Trp Thr Gly Ser Ala Arg Leu Gln Leu Phe Ser His 
        195                 200                 205             


Ala Leu Ala Pro Leu Ala Asp Leu Pro Val Leu Glu Ile Val Ser Ala 
    210                 215                 220                 


Ser His Ile Leu Thr Asp Leu Thr Leu Gly Thr Pro Lys Val Val His 
225                 230                 235                 240 


Asp Tyr Leu Ser Val Lys 
                245     


<210>  19
<211>  1056
<212>  DNA
<213>  C. beijerinckii

<400>  19
atgaaaggtt ttgcaatgct aggtattaat aagttaggat ggatcgaaaa agaaaggcca       60

gttgcgggtt catatgatgc tattgtacgc ccattagcag tatctccgtg tacatcagat      120

atacatactg tttttgaggg agctcttgga gataggaaga atatgatttt agggcatgaa      180

gctgtaggtg aagttgttga agtaggaagt gaagtgaagg attttaaacc tggtgacaga      240

gttatagttc cttgtacaac tccagattgg agatctttgg aagttcaagc tggttttcaa      300

cagcactcaa acggtatgct cgcaggatgg aaattttcaa atttcaagga tggagttttt      360

ggtgaatatt ttcatgtaaa tgatgcggat atgaatcttg cgattctacc taaagacatg      420

ccattagaaa atgctgttat gataacagat atgatgacta ctggatttca tggagcagaa      480

cttgcagata ttcaaatggg ttcaagtgtt gtggtaattg gcattggagc tgttggctta      540

atgggaatag caggtgctaa attacgtgga gcaggtagaa taattggagt ggggagcagg      600

ccgatttgtg ttgaggctgc aaaattttat ggagcaacag atattctaaa ttataaaaat      660

ggtcatatag ttgatcaagt tatgaaatta acgaatggaa aaggcgttga ccgcgtaatt      720

atggcaggcg gtggttctga aacattatcc caagcagtat ctatggttaa accaggagga      780

ataatttcta atataaatta tcatggaagt ggagatgctt tactaatacc acgtgtagaa      840

tggggatgtg gaatggctca caagactata aaaggaggtc tttgtcctgg gggacgtttg      900

agagcagaaa tgttaagaga tatggtagta tataatcgtg ttgatctaag taaattagtt      960

acacatgtat atcatggatt tgatcacata gaagaagcac tgttattaat gaaagacaag     1020

ccaaaagact taattaaagc agtagttata ttataa                               1056


<210>  20
<211>  1056
<212>  DNA
<213>  C. beijerinckii

<400>  20
atgaagggat tcgccatgct agggattaac aagttaggtt ggattgagaa agaacgtcca       60

gtagcaggga gctacgacgc catcgttcgt ccccttgcgg tttccccttg cacttcggac      120

attcacaccg ttttcgaagg cgctctgggc gaccgcaaaa acatgatctt agggcacgaa      180

gccgtaggtg aagtggtgga agtcgggagt gaggttaaag atttcaaacc tggggatcgt      240

gtcattgtac cgtgcacaac tccggactgg cgctcgttgg aagtacaggc tggattccaa      300

cagcactcta acgggatgtt ggctggctgg aaattctcga acttcaaaga tggggtcttc      360

ggtgagtact tccacgtgaa cgacgctgac atgaacttgg caattctgcc taaggacatg      420

ccactggaaa acgcagttat gattaccgac atgatgacca ctgggttcca cggtgcagaa      480

ttagcagata tccagatggg aagttctgtg gttgtaattg gtattggagc cgtcggcctc      540

atggggatcg caggtgccaa attgcgtggg gcaggtcgca tcatcggagt ggggtctcgt      600

cccatttgcg tagaagcggc taagttctat ggtgccacgg acattctcaa ctacaagaac      660

ggccacatcg tcgaccaagt tatgaagttg actaacggca aaggtgttga ccgggtcatt      720

atggcaggtg gtggtagtga gacattaagc caagctgtta gtatggttaa accgggtggc      780

attatcagta acatcaacta ccacggaagc ggtgatgctc tgctgattcc gcgtgtcgag      840

tggggttgcg gcatggcaca caagacaatc aaaggtggtc tatgtcccgg aggtcgcctt      900

cgtgcggaga tgcttcgcga catggttgtc tacaaccggg tcgacttaag caaattggta      960

acacacgtgt accacggttt cgaccacatt gaagaagcac tgttgttaat gaaagacaag     1020

ccaaaggact tgatcaaagc cgttgtgatc ttatag                               1056


<210>  21
<211>  351
<212>  PRT
<213>  C. beijerinckii

<400>  21

Met Lys Gly Phe Ala Met Leu Gly Ile Asn Lys Leu Gly Trp Ile Glu 
1               5                   10                  15      


Lys Glu Arg Pro Val Ala Gly Ser Tyr Asp Ala Ile Val Arg Pro Leu 
            20                  25                  30          


Ala Val Ser Pro Cys Thr Ser Asp Ile His Thr Val Phe Glu Gly Ala 
        35                  40                  45              


Leu Gly Asp Arg Lys Asn Met Ile Leu Gly His Glu Ala Val Gly Glu 
    50                  55                  60                  


Val Val Glu Val Gly Ser Glu Val Lys Asp Phe Lys Pro Gly Asp Arg 
65                  70                  75                  80  


Val Ile Val Pro Cys Thr Thr Pro Asp Trp Arg Ser Leu Glu Val Gln 
                85                  90                  95      


Ala Gly Phe Gln Gln His Ser Asn Gly Met Leu Ala Gly Trp Lys Phe 
            100                 105                 110         


Ser Asn Phe Lys Asp Gly Val Phe Gly Glu Tyr Phe His Val Asn Asp 
        115                 120                 125             


Ala Asp Met Asn Leu Ala Ile Leu Pro Lys Asp Met Pro Leu Glu Asn 
    130                 135                 140                 


Ala Val Met Ile Thr Asp Met Met Thr Thr Gly Phe His Gly Ala Glu 
145                 150                 155                 160 


Leu Ala Asp Ile Gln Met Gly Ser Ser Val Val Val Ile Gly Ile Gly 
                165                 170                 175     


Ala Val Gly Leu Met Gly Ile Ala Gly Ala Lys Leu Arg Gly Ala Gly 
            180                 185                 190         


Arg Ile Ile Gly Val Gly Ser Arg Pro Ile Cys Val Glu Ala Ala Lys 
        195                 200                 205             


Phe Tyr Gly Ala Thr Asp Ile Leu Asn Tyr Lys Asn Gly His Ile Val 
    210                 215                 220                 


Asp Gln Val Met Lys Leu Thr Asn Gly Lys Gly Val Asp Arg Val Ile 
225                 230                 235                 240 


Met Ala Gly Gly Gly Ser Glu Thr Leu Ser Gln Ala Val Ser Met Val 
                245                 250                 255     


Lys Pro Gly Gly Ile Ile Ser Asn Ile Asn Tyr His Gly Ser Gly Asp 
            260                 265                 270         


Ala Leu Leu Ile Pro Arg Val Glu Trp Gly Cys Gly Met Ala His Lys 
        275                 280                 285             


Thr Ile Lys Gly Gly Leu Cys Pro Gly Gly Arg Leu Arg Ala Glu Met 
    290                 295                 300                 


Leu Arg Asp Met Val Val Tyr Asn Arg Val Asp Leu Ser Lys Leu Val 
305                 310                 315                 320 


Thr His Val Tyr His Gly Phe Asp His Ile Glu Glu Ala Leu Leu Leu 
                325                 330                 335     


Met Lys Asp Lys Pro Lys Asp Leu Ile Lys Ala Val Val Ile Leu 
            340                 345                 350     


<210>  22
<211>  1059
<212>  DNA
<213>  Thermoanaerobacter ethanolicus

<400>  22
atgaaaggtt ttgcaatgct cagtatcggt aaagtcggtt ggattgaaaa agaaaagcct       60

actcccggcc cttttgacgc tatcgtaaga cctctagctg tggccccttg cacttcggac      120

gttcataccg tttttgaagg tgctattggc gaaagacata acatgatact cggtcacgaa      180

gctgtaggtg aagtagttga agtaggtagt gaggtaaaag attttaaacc tggtgatcgc      240

gttgttgtac cagctattac ccctgattgg cgaacctctg aagtacaaag aggatatcac      300

caacactctg gtggaatgct ggcaggctgg aaattttcga atataaaaga tggtgttttt      360

ggtgaatttt ttcatgtgaa cgatgctgat atgaatttag cacatctgcc taaggaaatt      420

ccattggaag ctgcagttat gattcccgat atgatgacta ctggctttca cggagccgaa      480

ctggcagaaa tagaattagg tgcaacggta gcggttttgg gtattggtcc agtaggtctt      540

atggcagtcg ctggtgccaa attgcggggt gctggaagaa ttattgcagt aggcagtaga      600

cctgtttgtg tagatgctgc aaaatactat ggagctactg atattgtaaa ctataaaaat      660

ggtcctatcg aaagccagat tatggattta acggaaggca aaggtgttga tgctgccatc      720

atcgctggag gaaatgctga cattatggct acagcagtta agattgttaa accaggcggc      780

accatcgcta atgtaaatta ttttggcgaa ggagatgttc tgcctgttcc tcgtcttgaa      840

tggggttgcg gcatggctca taaagctata aaaggcggtt tatgccctgg tggacgtcta      900

agaatggaaa gactgattga ccttgttttt tataagcgtg tcgatccttc caaactcgtc      960

actcatgttt ttcaaggatt tgataatatt gaaaaagctc taatgctgat gaaagataaa     1020

ccaaaagacc taatcaaacc tgttgtaata ttagcataa                            1059


<210>  23
<211>  1059
<212>  DNA
<213>  Thermoanaerobacter ethanolicus

<400>  23
atgaaggggt ttgcaatgct ctcgattggt aaggtgggtt ggattgaaaa agaaaaacca       60

acaccaggtc cttttgacgc cattgtacgt ccgttggccg ttgctccgtg cacgtcagat      120

gttcacacgg ttttcgaagg ggcaattggt gaacgtcata acatgatctt aggccatgag      180

gcagttggcg aagttgtaga ggtgggtagt gaggttaagg acttcaaacc cggtgatcgg      240

gtagtcgttc cagcaattac tccggattgg cgtacaagtg aggtccaacg tggctaccat      300

cagcactccg gtggtatgct cgcaggttgg aaattcagca acatcaaaga tggggtattt      360

ggcgagttct tccacgttaa tgatgccgac atgaacttag ctcatttacc taaagaaatt      420

ccattagaag cggctgttat gattcccgat atgatgacga ctggctttca tggtgcggaa      480

ttggcagaaa ttgagctcgg agcgaccgtt gcagtcttgg gcattggccc tgtaggtttg      540

atggcagttg cgggtgcgaa acttcgtggc gctggacgga tcatcgctgt gggttcgcgt      600

ccagtctgcg tagatgcagc caagtactat ggagctactg atattgtcaa ctacaagaat      660

gggcctattg agtctcagat tatggatctt accgagggta aaggtgtgga tgcagcgatc      720

attgcgggag ggaatgcgga cattatggct actgccgtga agattgtaaa acctggtggc      780

acaattgcaa acgttaacta ctttggtgaa ggtgatgtct tgccggttcc acgtcttgaa      840

tgggggtgtg gtatggctca caaagctatc aagggtgggt tgtgcccagg tggtcggctg      900

cgtatggaac gcctaattga tttagttttc tacaaacgcg ttgatccatc caagttagtt      960

actcatgtct tccaagggtt cgacaacatt gaaaaagcac tcatgttaat gaaagataaa     1020

ccgaaggact tgattaagcc ggttgtcatc ttagcgtag                            1059


<210>  24
<211>  352
<212>  PRT
<213>  Thermoanaerobacter ethanolicus

<400>  24

Met Lys Gly Phe Ala Met Leu Ser Ile Gly Lys Val Gly Trp Ile Glu 
1               5                   10                  15      


Lys Glu Lys Pro Thr Pro Gly Pro Phe Asp Ala Ile Val Arg Pro Leu 
            20                  25                  30          


Ala Val Ala Pro Cys Thr Ser Asp Val His Thr Val Phe Glu Gly Ala 
        35                  40                  45              


Ile Gly Glu Arg His Asn Met Ile Leu Gly His Glu Ala Val Gly Glu 
    50                  55                  60                  


Val Val Glu Val Gly Ser Glu Val Lys Asp Phe Lys Pro Gly Asp Arg 
65                  70                  75                  80  


Val Val Val Pro Ala Ile Thr Pro Asp Trp Arg Thr Ser Glu Val Gln 
                85                  90                  95      


Arg Gly Tyr His Gln His Ser Gly Gly Met Leu Ala Gly Trp Lys Phe 
            100                 105                 110         


Ser Asn Ile Lys Asp Gly Val Phe Gly Glu Phe Phe His Val Asn Asp 
        115                 120                 125             


Ala Asp Met Asn Leu Ala His Leu Pro Lys Glu Ile Pro Leu Glu Ala 
    130                 135                 140                 


Ala Val Met Ile Pro Asp Met Met Thr Thr Gly Phe His Gly Ala Glu 
145                 150                 155                 160 


Leu Ala Glu Ile Glu Leu Gly Ala Thr Val Ala Val Leu Gly Ile Gly 
                165                 170                 175     


Pro Val Gly Leu Met Ala Val Ala Gly Ala Lys Leu Arg Gly Ala Gly 
            180                 185                 190         


Arg Ile Ile Ala Val Gly Ser Arg Pro Val Cys Val Asp Ala Ala Lys 
        195                 200                 205             


Tyr Tyr Gly Ala Thr Asp Ile Val Asn Tyr Lys Asn Gly Pro Ile Glu 
    210                 215                 220                 


Ser Gln Ile Met Asp Leu Thr Glu Gly Lys Gly Val Asp Ala Ala Ile 
225                 230                 235                 240 


Ile Ala Gly Gly Asn Ala Asp Ile Met Ala Thr Ala Val Lys Ile Val 
                245                 250                 255     


Lys Pro Gly Gly Thr Ile Ala Asn Val Asn Tyr Phe Gly Glu Gly Asp 
            260                 265                 270         


Val Leu Pro Val Pro Arg Leu Glu Trp Gly Cys Gly Met Ala His Lys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Cys Pro Gly Gly Arg Leu Arg Met Glu Arg 
    290                 295                 300                 


Leu Ile Asp Leu Val Phe Tyr Lys Arg Val Asp Pro Ser Lys Leu Val 
305                 310                 315                 320 


Thr His Val Phe Gln Gly Phe Asp Asn Ile Glu Lys Ala Leu Met Leu 
                325                 330                 335     


Met Lys Asp Lys Pro Lys Asp Leu Ile Lys Pro Val Val Ile Leu Ala 
            340                 345                 350         


<210>  25
<211>  1179
<212>  DNA
<213>  L. reuteri

<400>  25
atggagaagg tttacattgt tgctgctcag cgaacaccaa tcggtaagtt taacggtcag       60

ttagcttcaa agtctgcagt tgaattagga gcgattgcaa ttaaagcggc tgttgaaaag      120

gcaaagctca gcgaaaacga tattgaccaa gtgttaatgg ggaatgttat tcaagcagga      180

acgggacaaa atccagcgcg tcaagcatca atggccgctg gattaggtga gcaggttccg      240

gcaataacga ttaatgacgt ctgtgcgtcg ggaatgtcca gtgttgacct ggcagcaagt      300

ttgattcgcg caggacaggc taatgtaatt gttgccgggg ggatggaaag tatgtcccaa      360

gctccatatg ttcttcctaa ggcacggaat ggctatcgat ttgggaatgg aaccttgctt      420

gatgcgatgc aaagtgatgc attaaatgat gtttatggcg gttatccgat gggaattact      480

gctgaaaata tcaatgataa gtatcagatt actcgtcacc aacaagacga atttgctttg      540

atgagccacc aacgtgcggt aaaggctcaa aaagcaggct atttcgattc agaaattgta      600

ccagttgaag ttaagcagaa acgaacaaca gtgactgtaa ctgttgacga agctccacga      660

ccagatactt cactagcggc tttagcaaaa ttaaaaccag cttttaaatc tgacggaagt      720

gtgactgcag ggaatgcctc gggaattaat gatggtggag ctgccttggt tcttgcttct      780

gaaagtgcag tcaaccgatt aggattaact ccattggctg agtggcaagg atctgcagtt      840

gttggtcttg atccagcatt gatgggtttg ggaccatatt atgcaatcaa gaagctctta      900

aaaaatcagc agctgtcggc agatgacgta gatacttacg aaattaatga ggcgtttgcg      960

acccaagccc ttgtctgtca gaacttgctt catcttgatc ctagggctgt caatccttgg     1020

ggtggggcaa ttgcattagg ccatcctgtt gggtgttcag gagcacgaat tatcgtcacg     1080

atgattagtg aaatgcatag ggataatcat gaactcggca ttgcttcgct gtgtgtcggg     1140

ggcggaatgg gtgaagcggt tctgcttaag aaaatttag                            1179


<210>  26
<211>  392
<212>  PRT
<213>  L. reuteri

<400>  26

Met Glu Lys Val Tyr Ile Val Ala Ala Gln Arg Thr Pro Ile Gly Lys 
1               5                   10                  15      


Phe Asn Gly Gln Leu Ala Ser Lys Ser Ala Val Glu Leu Gly Ala Ile 
            20                  25                  30          


Ala Ile Lys Ala Ala Val Glu Lys Ala Lys Leu Ser Glu Asn Asp Ile 
        35                  40                  45              


Asp Gln Val Leu Met Gly Asn Val Ile Gln Ala Gly Thr Gly Gln Asn 
    50                  55                  60                  


Pro Ala Arg Gln Ala Ser Met Ala Ala Gly Leu Gly Glu Gln Val Pro 
65                  70                  75                  80  


Ala Ile Thr Ile Asn Asp Val Cys Ala Ser Gly Met Ser Ser Val Asp 
                85                  90                  95      


Leu Ala Ala Ser Leu Ile Arg Ala Gly Gln Ala Asn Val Ile Val Ala 
            100                 105                 110         


Gly Gly Met Glu Ser Met Ser Gln Ala Pro Tyr Val Leu Pro Lys Ala 
        115                 120                 125             


Arg Asn Gly Tyr Arg Phe Gly Asn Gly Thr Leu Leu Asp Ala Met Gln 
    130                 135                 140                 


Ser Asp Ala Leu Asn Asp Val Tyr Gly Gly Tyr Pro Met Gly Ile Thr 
145                 150                 155                 160 


Ala Glu Asn Ile Asn Asp Lys Tyr Gln Ile Thr Arg His Gln Gln Asp 
                165                 170                 175     


Glu Phe Ala Leu Met Ser His Gln Arg Ala Val Lys Ala Gln Lys Ala 
            180                 185                 190         


Gly Tyr Phe Asp Ser Glu Ile Val Pro Val Glu Val Lys Gln Lys Arg 
        195                 200                 205             


Thr Thr Val Thr Val Thr Val Asp Glu Ala Pro Arg Pro Asp Thr Ser 
    210                 215                 220                 


Leu Ala Ala Leu Ala Lys Leu Lys Pro Ala Phe Lys Ser Asp Gly Ser 
225                 230                 235                 240 


Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Gly Gly Ala Ala Leu 
                245                 250                 255     


Val Leu Ala Ser Glu Ser Ala Val Asn Arg Leu Gly Leu Thr Pro Leu 
            260                 265                 270         


Ala Glu Trp Gln Gly Ser Ala Val Val Gly Leu Asp Pro Ala Leu Met 
        275                 280                 285             


Gly Leu Gly Pro Tyr Tyr Ala Ile Lys Lys Leu Leu Lys Asn Gln Gln 
    290                 295                 300                 


Leu Ser Ala Asp Asp Val Asp Thr Tyr Glu Ile Asn Glu Ala Phe Ala 
305                 310                 315                 320 


Thr Gln Ala Leu Val Cys Gln Asn Leu Leu His Leu Asp Pro Arg Ala 
                325                 330                 335     


Val Asn Pro Trp Gly Gly Ala Ile Ala Leu Gly His Pro Val Gly Cys 
            340                 345                 350         


Ser Gly Ala Arg Ile Ile Val Thr Met Ile Ser Glu Met His Arg Asp 
        355                 360                 365             


Asn His Glu Leu Gly Ile Ala Ser Leu Cys Val Gly Gly Gly Met Gly 
    370                 375                 380                 


Glu Ala Val Leu Leu Lys Lys Ile 
385                 390         


<210>  27
<211>  651
<212>  DNA
<213>  E. coli

<400>  27
atggatgcta aacagcgcat tgcacgtcgt gttgcacagg agttgcgtga tggcgatatt       60

gtcaatttgg ggattggtct gccaactatg gtggccaatt acctccctga gggcattcac      120

attaccttac agtccgaaaa tggctttttg ggcttaggtc cagttactac tgcacatccc      180

gacttagtga atgcaggtgg gcaaccctgt ggggttcttc caggtgcggc aatgttcgat      240

tccgcaatga gctttgcttt gattcgggga ggtcacatcg acgcgtgcgt tctgggtggt      300

ctccaagtcg atgaagaagc caatttggca aattgggttg tacctggcaa aatggtgcca      360

ggcatgggag gggctatgga tttagtcacg ggttcacgga aagtcatcat tgcaatggaa      420

cattgcgcaa aagatggcag tgccaagatt cttcggcgtt gcacaatgcc gttaacagcg      480

caacacgcag ttcatatgtt agttactgaa ctggccgttt tccgcttcat tgatgggaaa      540

atgtggttaa ctgaaattgc agatggttgc gatttggcca cagttcgcgc taaaaccgaa      600

gcgcgttttg aggttgcagc cgatctcaat acccagcgtg gtgacttgta g               651


<210>  28
<211>  216
<212>  PRT
<213>  E. coli

<400>  28

Met Asp Ala Lys Gln Arg Ile Ala Arg Arg Val Ala Gln Glu Leu Arg 
1               5                   10                  15      


Asp Gly Asp Ile Val Asn Leu Gly Ile Gly Leu Pro Thr Met Val Ala 
            20                  25                  30          


Asn Tyr Leu Pro Glu Gly Ile His Ile Thr Leu Gln Ser Glu Asn Gly 
        35                  40                  45              


Phe Leu Gly Leu Gly Pro Val Thr Thr Ala His Pro Asp Leu Val Asn 
    50                  55                  60                  


Ala Gly Gly Gln Pro Cys Gly Val Leu Pro Gly Ala Ala Met Phe Asp 
65                  70                  75                  80  


Ser Ala Met Ser Phe Ala Leu Ile Arg Gly Gly His Ile Asp Ala Cys 
                85                  90                  95      


Val Leu Gly Gly Leu Gln Val Asp Glu Glu Ala Asn Leu Ala Asn Trp 
            100                 105                 110         


Val Val Pro Gly Lys Met Val Pro Gly Met Gly Gly Ala Met Asp Leu 
        115                 120                 125             


Val Thr Gly Ser Arg Lys Val Ile Ile Ala Met Glu His Cys Ala Lys 
    130                 135                 140                 


Asp Gly Ser Ala Lys Ile Leu Arg Arg Cys Thr Met Pro Leu Thr Ala 
145                 150                 155                 160 


Gln His Ala Val His Met Leu Val Thr Glu Leu Ala Val Phe Arg Phe 
                165                 170                 175     


Ile Asp Gly Lys Met Trp Leu Thr Glu Ile Ala Asp Gly Cys Asp Leu 
            180                 185                 190         


Ala Thr Val Arg Ala Lys Thr Glu Ala Arg Phe Glu Val Ala Ala Asp 
        195                 200                 205             


Leu Asn Thr Gln Arg Gly Asp Leu 
    210                 215     


<210>  29
<211>  663
<212>  DNA
<213>  E. coli

<400>  29
atgaaaacca aattgatgac actccaagat gcaacggggt tctttcgtga tggcatgacc       60

attatggttg gtggctttat gggtattggg accccatctc gcttggttga agcattgctc      120

gaatctggtg tgcgggatct gaccttgatt gcaaacgata ctgcatttgt tgatacaggt      180

attgggcctt tgattgtcaa tggtcgcgtc cgtaaggtga tcgcatccca tattgggaca      240

aatcctgaaa ctgggcgtcg tatgatttct ggcgaaatgg atgttgtcct cgtaccccag      300

ggtactctca tcgaacagat tcgttgtggc ggtgcaggtc ttggtggctt cttgacccct      360

acgggtgttg ggactgtggt cgaagaagga aaacaaacgc tcacgctcga tggcaagacg      420

tggttattgg aacgtccctt acgtgcagat ttagcattga ttcgtgccca ccgttgcgac      480

accttaggta atctcacata tcagttaagt gcccgtaact ttaacccatt gattgctctt      540

gcagccgaca tcaccttagt cgaacccgat gaattagttg aaactggtga gctgcaacct      600

gatcatattg ttacaccagg tgcggttatt gaccacatca ttgtgagcca agagtctaaa      660

tag                                                                    663


<210>  30
<211>  220
<212>  PRT
<213>  E. coli

<400>  30

Met Lys Thr Lys Leu Met Thr Leu Gln Asp Ala Thr Gly Phe Phe Arg 
1               5                   10                  15      


Asp Gly Met Thr Ile Met Val Gly Gly Phe Met Gly Ile Gly Thr Pro 
            20                  25                  30          


Ser Arg Leu Val Glu Ala Leu Leu Glu Ser Gly Val Arg Asp Leu Thr 
        35                  40                  45              


Leu Ile Ala Asn Asp Thr Ala Phe Val Asp Thr Gly Ile Gly Pro Leu 
    50                  55                  60                  


Ile Val Asn Gly Arg Val Arg Lys Val Ile Ala Ser His Ile Gly Thr 
65                  70                  75                  80  


Asn Pro Glu Thr Gly Arg Arg Met Ile Ser Gly Glu Met Asp Val Val 
                85                  90                  95      


Leu Val Pro Gln Gly Thr Leu Ile Glu Gln Ile Arg Cys Gly Gly Ala 
            100                 105                 110         


Gly Leu Gly Gly Phe Leu Thr Pro Thr Gly Val Gly Thr Val Val Glu 
        115                 120                 125             


Glu Gly Lys Gln Thr Leu Thr Leu Asp Gly Lys Thr Trp Leu Leu Glu 
    130                 135                 140                 


Arg Pro Leu Arg Ala Asp Leu Ala Leu Ile Arg Ala His Arg Cys Asp 
145                 150                 155                 160 


Thr Leu Gly Asn Leu Thr Tyr Gln Leu Ser Ala Arg Asn Phe Asn Pro 
                165                 170                 175     


Leu Ile Ala Leu Ala Ala Asp Ile Thr Leu Val Glu Pro Asp Glu Leu 
            180                 185                 190         


Val Glu Thr Gly Glu Leu Gln Pro Asp His Ile Val Thr Pro Gly Ala 
        195                 200                 205             


Val Ile Asp His Ile Ile Val Ser Gln Glu Ser Lys 
    210                 215                 220 


<210>  31
<211>  657
<212>  DNA
<213>  C. acetobutylicum

<400>  31
atgaacagta agatcatccg tttcgagaac ttacgtagct tcttcaagga cggtatgacc       60

attatgattg ggggtttctt aaactgcggt actcctacca agttgatcga cttcttagtg      120

aacttgaaca tcaagaactt aaccatcatc tcaaacgaca cctgctaccc taacaccgga      180

atcggtaagt taatctcaaa caaccaggtt aagaagttaa tcgcctcata catcggcagc      240

aaccctgaca ccggcaagaa gctcttcaac aacgagttag aggtagagtt atcacctcag      300

gggaccttag tggagcgcat tcgggcaggg ggtagtgggc tcggaggagt tttgactaag      360

acgggattag gcaccttgat cgagaagggc aagaagaaga tcagtatcaa cggcaccgag      420

tacctgcttg agttaccctt aaccgctgac gtagccttaa tcaagggctc gatcgtcgac      480

gaagcgggta acaccttcta caagggtaca acgaagaact tcaacccgta catggctatg      540

gcagcgaaga ccgttatcgt agaggccgag aacttggttt catgcgagaa acttgagaag      600

gagaaggcta tgacacctgg tgttttgatc aactacatcg tgaaggagcc tgcctag         657


<210>  32
<211>  218
<212>  PRT
<213>  C. acetobutylicum

<400>  32

Met Asn Ser Lys Ile Ile Arg Phe Glu Asn Leu Arg Ser Phe Phe Lys 
1               5                   10                  15      


Asp Gly Met Thr Ile Met Ile Gly Gly Phe Leu Asn Cys Gly Thr Pro 
            20                  25                  30          


Thr Lys Leu Ile Asp Phe Leu Val Asn Leu Asn Ile Lys Asn Leu Thr 
        35                  40                  45              


Ile Ile Ser Asn Asp Thr Cys Tyr Pro Asn Thr Gly Ile Gly Lys Leu 
    50                  55                  60                  


Ile Ser Asn Asn Gln Val Lys Lys Leu Ile Ala Ser Tyr Ile Gly Ser 
65                  70                  75                  80  


Asn Pro Asp Thr Gly Lys Lys Leu Phe Asn Asn Glu Leu Glu Val Glu 
                85                  90                  95      


Leu Ser Pro Gln Gly Thr Leu Val Glu Arg Ile Arg Ala Gly Gly Ser 
            100                 105                 110         


Gly Leu Gly Gly Val Leu Thr Lys Thr Gly Leu Gly Thr Leu Ile Glu 
        115                 120                 125             


Lys Gly Lys Lys Lys Ile Ser Ile Asn Gly Thr Glu Tyr Leu Leu Glu 
    130                 135                 140                 


Leu Pro Leu Thr Ala Asp Val Ala Leu Ile Lys Gly Ser Ile Val Asp 
145                 150                 155                 160 


Glu Ala Gly Asn Thr Phe Tyr Lys Gly Thr Thr Lys Asn Phe Asn Pro 
                165                 170                 175     


Tyr Met Ala Met Ala Ala Lys Thr Val Ile Val Glu Ala Glu Asn Leu 
            180                 185                 190         


Val Ser Cys Glu Lys Leu Glu Lys Glu Lys Ala Met Thr Pro Gly Val 
        195                 200                 205             


Leu Ile Asn Tyr Ile Val Lys Glu Pro Ala 
    210                 215             


<210>  33
<211>  666
<212>  DNA
<213>  C. acetobutylicum

<400>  33
atgatcaacg acaagaactt ggctaaggag attatcgcca agcgcgttgc ccgtgagtta       60

aagaacggcc agctcgttaa ccttggtgtc ggtctcccaa cgatggttgc cgactacatc      120

cccaagaact tcaagattac attccagtcg gaaaacggta ttgttggtat gggtgccagt      180

ccaaagatca acgaggcaga caaggacgtt gttaacgcag gtggggacta caccactgtg      240

ctgcccgacg gaaccttctt cgacagttct gttagtttca gccttatccg tggtggacac      300

gttgacgtca ctgttttagg tgctttgcag gtcgacgaaa aggggaacat cgcaaactgg      360

atcgttcccg gaaagatgtt gtcaggaatg ggtggggcaa tggaccttgt caacggagcg      420

aagaaggtga ttatcgctat gcgccacacg aacaaggggc agccgaagat cttgaagaag      480

tgcactttac cgttgacggc caagagccag gctaacctga tcgttacgga actcggtgtt      540

attgaagtta tcaacgacgg cttgttattg acggagatta acaagaacac aaccattgac      600

gaaattcgct cattaactgc cgctgacctc ttgatcagta acgaattacg ccctatggca      660

gtatag                                                                 666


<210>  34
<211>  221
<212>  PRT
<213>  C. acetobutylicum

<400>  34

Met Ile Asn Asp Lys Asn Leu Ala Lys Glu Ile Ile Ala Lys Arg Val 
1               5                   10                  15      


Ala Arg Glu Leu Lys Asn Gly Gln Leu Val Asn Leu Gly Val Gly Leu 
            20                  25                  30          


Pro Thr Met Val Ala Asp Tyr Ile Pro Lys Asn Phe Lys Ile Thr Phe 
        35                  40                  45              


Gln Ser Glu Asn Gly Ile Val Gly Met Gly Ala Ser Pro Lys Ile Asn 
    50                  55                  60                  


Glu Ala Asp Lys Asp Val Val Asn Ala Gly Gly Asp Tyr Thr Thr Val 
65                  70                  75                  80  


Leu Pro Asp Gly Thr Phe Phe Asp Ser Ser Val Ser Phe Ser Leu Ile 
                85                  90                  95      


Arg Gly Gly His Val Asp Val Thr Val Leu Gly Ala Leu Gln Val Asp 
            100                 105                 110         


Glu Lys Gly Asn Ile Ala Asn Trp Ile Val Pro Gly Lys Met Leu Ser 
        115                 120                 125             


Gly Met Gly Gly Ala Met Asp Leu Val Asn Gly Ala Lys Lys Val Ile 
    130                 135                 140                 


Ile Ala Met Arg His Thr Asn Lys Gly Gln Pro Lys Ile Leu Lys Lys 
145                 150                 155                 160 


Cys Thr Leu Pro Leu Thr Ala Lys Ser Gln Ala Asn Leu Ile Val Thr 
                165                 170                 175     


Glu Leu Gly Val Ile Glu Val Ile Asn Asp Gly Leu Leu Leu Thr Glu 
            180                 185                 190         


Ile Asn Lys Asn Thr Thr Ile Asp Glu Ile Arg Ser Leu Thr Ala Ala 
        195                 200                 205             


Asp Leu Leu Ile Ser Asn Glu Leu Arg Pro Met Ala Val 
    210                 215                 220     


<210>  35
<211>  780
<212>  DNA
<213>  C. acetobutylicum

<400>  35
atgctagaaa agttaaacat catcaagttc cgtaaggtta ctttcatgtt aaaggacgag       60

gtcattaagc agattagcac accgttaaca tcgccagcat tccctcgtgg accttacaag      120

ttccacaacc gggaatactt caacatcgtg taccgcaccg acatggacgc actgcgcaag      180

gtcgttccgg aaccgcttga aattgacgaa cctctagtac gtttcgagat tatggcaatg      240

cacgacacca gtgggttagg ttgctacacg gaaagtggtc aggcaattcc agttagcttc      300

aacggtgtca agggcgacta cttgcacatg atgtacctgg acaacgaacc ggctatcgca      360

gtaggtcgtg aattgtctgc atacccaaag aagttaggct accctaagtt attcgtcgac      420

agcgacacat tagtagggac attggactac ggaaagttac gggtggcaac agcaactatg      480

ggttacaagc acaaggcgct tgacgcaaac gaggcgaagg accagatctg ccgtccgaac      540

tacatgctta agatcattcc caactacgac ggctctcctc gtatttgcga actcattaac      600

gcaaagatta cagacgttac ggttcacgaa gcatggactg gtcctactcg gctgcagtta      660

ttcgaccacg cgatggcacc actgaacgac ctgccagtaa aggaaatcgt ctcttcatcg      720

cacatccttg cagacatcat ccttcctcgt gcagaagtaa tctacgacta cttgaagtag      780


<210>  36
<211>  259
<212>  PRT
<213>  C. acetobutylicum

<400>  36

Met Leu Glu Lys Leu Asn Ile Ile Lys Phe Arg Lys Val Thr Phe Met 
1               5                   10                  15      


Leu Lys Asp Glu Val Ile Lys Gln Ile Ser Thr Pro Leu Thr Ser Pro 
            20                  25                  30          


Ala Phe Pro Arg Gly Pro Tyr Lys Phe His Asn Arg Glu Tyr Phe Asn 
        35                  40                  45              


Ile Val Tyr Arg Thr Asp Met Asp Ala Leu Arg Lys Val Val Pro Glu 
    50                  55                  60                  


Pro Leu Glu Ile Asp Glu Pro Leu Val Arg Phe Glu Ile Met Ala Met 
65                  70                  75                  80  


His Asp Thr Ser Gly Leu Gly Cys Tyr Thr Glu Ser Gly Gln Ala Ile 
                85                  90                  95      


Pro Val Ser Phe Asn Gly Val Lys Gly Asp Tyr Leu His Met Met Tyr 
            100                 105                 110         


Leu Asp Asn Glu Pro Ala Ile Ala Val Gly Arg Glu Leu Ser Ala Tyr 
        115                 120                 125             


Pro Lys Lys Leu Gly Tyr Pro Lys Leu Phe Val Asp Ser Asp Thr Leu 
    130                 135                 140                 


Val Gly Thr Leu Asp Tyr Gly Lys Leu Arg Val Ala Thr Ala Thr Met 
145                 150                 155                 160 


Gly Tyr Lys His Lys Ala Leu Asp Ala Asn Glu Ala Lys Asp Gln Ile 
                165                 170                 175     


Cys Arg Pro Asn Tyr Met Leu Lys Ile Ile Pro Asn Tyr Asp Gly Ser 
            180                 185                 190         


Pro Arg Ile Cys Glu Leu Ile Asn Ala Lys Ile Thr Asp Val Thr Val 
        195                 200                 205             


His Glu Ala Trp Thr Gly Pro Thr Arg Leu Gln Leu Phe Asp His Ala 
    210                 215                 220                 


Met Ala Pro Leu Asn Asp Leu Pro Val Lys Glu Ile Val Ser Ser Ser 
225                 230                 235                 240 


His Ile Leu Ala Asp Ile Ile Leu Pro Arg Ala Glu Val Ile Tyr Asp 
                245                 250                 255     


Tyr Leu Lys 
            


<210>  37
<211>  1071
<212>  DNA
<213>  L. antri

<400>  37
atgcgtggtt tcgcgatgat tggtccaaac gaaaccgggt tcattgaaaa ggatgatccg       60

gaaatgggtc cacgggatgc gttagttaaa ccactagctg ttgcaccatg cacctcggat      120

atccacacgg tctacgaaaa cgcaattggc ccacggcaca acatgatctt aggtcacgag      180

gcttgtggcg aaatcgttgc agtgggtgat gaagtaaaag atttcaaagt aggggacaag      240

gttttagtac cagccgtgac ccctgattgg agcaaattgg aaagtcaagc cggttacgct      300

tctcacagtg ggggtatgct tgctggttgg aaattcagca acttcaagga tggcgtgttc      360

gcgacccgct tccacgtgaa cgatgcagat ggtaacttgg cgcaccttcc gttgggaatg      420

gacccaggtg aagcctgtat gttaagtgat atgattccga ccggattgca cgcagatgaa      480

atggccaacg tacaatacgg cgatacagta gcagttattg gtattggtcc cgtgggcttg      540

atggcccttc gtggggcagt cctgcacggt gcgggtcgca ttttcgctgt cggatctcgt      600

cccaaaacca ttgaagttgc aaaggagtat ggcgcaaccg acatcattga ttaccaccaa      660

ggtgatattg cggaccaaat cttgaagtta acggataacc agggggttga taaagttcta      720

attgctggtg gcgacactga acacactttc gatcaagcag cgcgtatgac gaaacccgga      780

ggtgcgattt caaacgttgc ttacttgaac ggtaacgatg tcttgaagat caaagctgca      840

gattggggag ttggcatgtc gaacattacc attgatggtg ggttgatgcc aggtggtcgc      900

ttgcgcatgg aaaaactcgc atcattgatt accaacggtc gtcttgaccc atccctaatg      960

atcacccaca agttctacgg tttcgagaag attccagatg ctctggagtt aatgcacaac     1020

aagcctgccg atctcatcaa acctgtcgtt tactgcgatg atattgatta g              1071


<210>  38
<211>  356
<212>  PRT
<213>  L. antri

<400>  38

Met Arg Gly Phe Ala Met Ile Gly Pro Asn Glu Thr Gly Phe Ile Glu 
1               5                   10                  15      


Lys Asp Asp Pro Glu Met Gly Pro Arg Asp Ala Leu Val Lys Pro Leu 
            20                  25                  30          


Ala Val Ala Pro Cys Thr Ser Asp Ile His Thr Val Tyr Glu Asn Ala 
        35                  40                  45              


Ile Gly Pro Arg His Asn Met Ile Leu Gly His Glu Ala Cys Gly Glu 
    50                  55                  60                  


Ile Val Ala Val Gly Asp Glu Val Lys Asp Phe Lys Val Gly Asp Lys 
65                  70                  75                  80  


Val Leu Val Pro Ala Val Thr Pro Asp Trp Ser Lys Leu Glu Ser Gln 
                85                  90                  95      


Ala Gly Tyr Ala Ser His Ser Gly Gly Met Leu Ala Gly Trp Lys Phe 
            100                 105                 110         


Ser Asn Phe Lys Asp Gly Val Phe Ala Thr Arg Phe His Val Asn Asp 
        115                 120                 125             


Ala Asp Gly Asn Leu Ala His Leu Pro Leu Gly Met Asp Pro Gly Glu 
    130                 135                 140                 


Ala Cys Met Leu Ser Asp Met Ile Pro Thr Gly Leu His Ala Asp Glu 
145                 150                 155                 160 


Met Ala Asn Val Gln Tyr Gly Asp Thr Val Ala Val Ile Gly Ile Gly 
                165                 170                 175     


Pro Val Gly Leu Met Ala Leu Arg Gly Ala Val Leu His Gly Ala Gly 
            180                 185                 190         


Arg Ile Phe Ala Val Gly Ser Arg Pro Lys Thr Ile Glu Val Ala Lys 
        195                 200                 205             


Glu Tyr Gly Ala Thr Asp Ile Ile Asp Tyr His Gln Gly Asp Ile Ala 
    210                 215                 220                 


Asp Gln Ile Leu Lys Leu Thr Asp Asn Gln Gly Val Asp Lys Val Leu 
225                 230                 235                 240 


Ile Ala Gly Gly Asp Thr Glu His Thr Phe Asp Gln Ala Ala Arg Met 
                245                 250                 255     


Thr Lys Pro Gly Gly Ala Ile Ser Asn Val Ala Tyr Leu Asn Gly Asn 
            260                 265                 270         


Asp Val Leu Lys Ile Lys Ala Ala Asp Trp Gly Val Gly Met Ser Asn 
        275                 280                 285             


Ile Thr Ile Asp Gly Gly Leu Met Pro Gly Gly Arg Leu Arg Met Glu 
    290                 295                 300                 


Lys Leu Ala Ser Leu Ile Thr Asn Gly Arg Leu Asp Pro Ser Leu Met 
305                 310                 315                 320 


Ile Thr His Lys Phe Tyr Gly Phe Glu Lys Ile Pro Asp Ala Leu Glu 
                325                 330                 335     


Leu Met His Asn Lys Pro Ala Asp Leu Ile Lys Pro Val Val Tyr Cys 
            340                 345                 350         


Asp Asp Ile Asp 
        355     


<210>  39
<211>  1155
<212>  DNA
<213>  Propionibacterium freudenreichii

<400>  39
atgaacacgc ttgccgataa cccggtcatt atcgaagcgc tgcgcacacc tattgggact       60

acgggtggtg tgtttgcgga tcaaactacc actgatctag cagcgccagt cttgggtgaa      120

ctcgacgctc ggctgcctac cggtactggt tttggcgaag ttgtgttagg taacgttcgt      180

gggcctggcg gtgatccagc acgtgttgcc gctttggctg cagggattga tccagcagta      240

ccagcgttaa cattagaccg ccagtgcggt agcggtatgg cagcaattga gtatgcatgg      300

caccgatgcc ggtcacaacc aggggtcgtt gctgccggag gtgtccaagc ggcaagcaca      360

cagcctatta cattatggcc tggccgtgat ggtgaaccac ccagttcgtt tgaccgtgcg      420

ccatttgccc cacctccgtg gttagatcct gatatggggg ttatggctga ccgtttagca      480

gctgaacttc acattagtcg tgaacgtcaa gatcgttatg cgctgcgctc tcatacccgt      540

gcctcaaccg cacgagatgc aggggatttc gatgcggaaa tcgtgccaat cgctcgtgta      600

cgtcgtgatc aacgtccacg ctcaggtttt actatggcac gcttggcacg tttcccagcg      660

gcttttcgcc ctggtggcac ggttacggca gcaaatagtt gtgggattaa cgacgcagca      720

gccgctgtga cgatggtaga tgctgctacc catgcgcact tagcaactcc aggcttgcgc      780

gtgttagctg cacgtacagt tggttatgat ccggaccggt ttgggttggg cctcgtaccg      840

gctgttcggg cagcgcttga cgacgctggt ttgggtttgg accaaattga tgcattagag      900

ttcaatgaag cgtttgcggc tcaagtattg gcttgtgcgg atgctttgga tttggatgag      960

catcgtctct gtccacgtgg cggagcaatt tcgctaggtc atccttgggg tgcgtccggt     1020

gccatcttac ttgttcgtct ctttagtcgc ttggtacgtg aaggcgcagg tcgttacggt     1080

ttggctgcga tttctattgg tggtgggcaa ggctctgctg ttgttgtcga ggcagtacat     1140

ccccgtggga attag                                                      1155


<210>  40
<211>  384
<212>  PRT
<213>  Propionibacterium freudenreichii

<400>  40

Met Asn Thr Leu Ala Asp Asn Pro Val Ile Ile Glu Ala Leu Arg Thr 
1               5                   10                  15      


Pro Ile Gly Thr Thr Gly Gly Val Phe Ala Asp Gln Thr Thr Thr Asp 
            20                  25                  30          


Leu Ala Ala Pro Val Leu Gly Glu Leu Asp Ala Arg Leu Pro Thr Gly 
        35                  40                  45              


Thr Gly Phe Gly Glu Val Val Leu Gly Asn Val Arg Gly Pro Gly Gly 
    50                  55                  60                  


Asp Pro Ala Arg Val Ala Ala Leu Ala Ala Gly Ile Asp Pro Ala Val 
65                  70                  75                  80  


Pro Ala Leu Thr Leu Asp Arg Gln Cys Gly Ser Gly Met Ala Ala Ile 
                85                  90                  95      


Glu Tyr Ala Trp His Arg Cys Arg Ser Gln Pro Gly Val Val Ala Ala 
            100                 105                 110         


Gly Gly Val Gln Ala Ala Ser Thr Gln Pro Ile Thr Leu Trp Pro Gly 
        115                 120                 125             


Arg Asp Gly Glu Pro Pro Ser Ser Phe Asp Arg Ala Pro Phe Ala Pro 
    130                 135                 140                 


Pro Pro Trp Leu Asp Pro Asp Met Gly Val Met Ala Asp Arg Leu Ala 
145                 150                 155                 160 


Ala Glu Leu His Ile Ser Arg Glu Arg Gln Asp Arg Tyr Ala Leu Arg 
                165                 170                 175     


Ser His Thr Arg Ala Ser Thr Ala Arg Asp Ala Gly Asp Phe Asp Ala 
            180                 185                 190         


Glu Ile Val Pro Ile Ala Arg Val Arg Arg Asp Gln Arg Pro Arg Ser 
        195                 200                 205             


Gly Phe Thr Met Ala Arg Leu Ala Arg Phe Pro Ala Ala Phe Arg Pro 
    210                 215                 220                 


Gly Gly Thr Val Thr Ala Ala Asn Ser Cys Gly Ile Asn Asp Ala Ala 
225                 230                 235                 240 


Ala Ala Val Thr Met Val Asp Ala Ala Thr His Ala His Leu Ala Thr 
                245                 250                 255     


Pro Gly Leu Arg Val Leu Ala Ala Arg Thr Val Gly Tyr Asp Pro Asp 
            260                 265                 270         


Arg Phe Gly Leu Gly Leu Val Pro Ala Val Arg Ala Ala Leu Asp Asp 
        275                 280                 285             


Ala Gly Leu Gly Leu Asp Gln Ile Asp Ala Leu Glu Phe Asn Glu Ala 
    290                 295                 300                 


Phe Ala Ala Gln Val Leu Ala Cys Ala Asp Ala Leu Asp Leu Asp Glu 
305                 310                 315                 320 


His Arg Leu Cys Pro Arg Gly Gly Ala Ile Ser Leu Gly His Pro Trp 
                325                 330                 335     


Gly Ala Ser Gly Ala Ile Leu Leu Val Arg Leu Phe Ser Arg Leu Val 
            340                 345                 350         


Arg Glu Gly Ala Gly Arg Tyr Gly Leu Ala Ala Ile Ser Ile Gly Gly 
        355                 360                 365             


Gly Gln Gly Ser Ala Val Val Val Glu Ala Val His Pro Arg Gly Asn 
    370                 375                 380                 


<210>  41
<211>  1170
<212>  DNA
<213>  Lactobacillus brevis

<400>  41
atggcagaag aggttgtgat tgttagtgcg gcacgtaccc ctatcggcaa gtttggcaaa       60

tccttacggg gattgagtgc agaacaacta ggcaccattg ccgctaaagc agcgattact      120

cgtagtggct tagatcctgc gacgattcaa cagaccatct ttggaagcgt gctgcaagct      180

gggcaaggcc aaaacattgc gcgtcagatc gaattgaacg caggcttacc agtcacttcg      240

accgcaatga ccattaacca ggtgtgtggc tcatccctca aagctattcg tttgggccag      300

tccgccattt tgatggggga tgccgatatc gttcttgtag gtggtacaga atccatgtcc      360

aatgcacctt accttactcc tcaaacccgt tggggtcata agtttggtga cattacgctt      420

acagattctc tcgcccatga tggtttaaca gacgctttta cggatatccc tatgggaatc      480

acggctgaga acgttgccgc acagttccac atctcacgtg ccgaccagga cgcttttgcc      540

cttcgttccc aacgtcgtgc cacggctgcc cagcaagcta atcggtttgc cgacgaaatt      600

gttcccgtaa gcctgggtac aacgactctc acaactgatg aagccgtccg gactaccact      660

tcgcgtgagc aactggcagc gttgcgtcca gcattcaaaa gtgttggcac cgttactgca      720

gggaacgctg caggcttgaa tgacggagcc gctgcgatga ttctgatgaa gaaaagtact      780

gcacgcgctg ctgggattgc gtacttggca acccttcgcg gttaccaaga agtcgggatt      840

gatccagcca tcatgggata tgctccggtt acagctattc agcaactcct tacgaaaact      900

cagcgcagtg tgtcggatat tgaccgtttt gaattgaatg aggcttttgc agcccaaagt      960

gttgctgtag gtcaagctct agcattacca gatgaccgct tgaatgttaa tggtggtgcc     1020

attgcactcg gtcatcctct aggtgcttcc ggcacccgta tcgtcgttac attgctgtac     1080

gaacttttgc attccgggac ccatttgggt gttgcttcta tgtgcattgg tggtggaatg     1140

ggaatggcat tgatgattga gtcgaattag                                      1170


<210>  42
<211>  389
<212>  PRT
<213>  Lactobacillus brevis

<400>  42

Met Ala Glu Glu Val Val Ile Val Ser Ala Ala Arg Thr Pro Ile Gly 
1               5                   10                  15      


Lys Phe Gly Lys Ser Leu Arg Gly Leu Ser Ala Glu Gln Leu Gly Thr 
            20                  25                  30          


Ile Ala Ala Lys Ala Ala Ile Thr Arg Ser Gly Leu Asp Pro Ala Thr 
        35                  40                  45              


Ile Gln Gln Thr Ile Phe Gly Ser Val Leu Gln Ala Gly Gln Gly Gln 
    50                  55                  60                  


Asn Ile Ala Arg Gln Ile Glu Leu Asn Ala Gly Leu Pro Val Thr Ser 
65                  70                  75                  80  


Thr Ala Met Thr Ile Asn Gln Val Cys Gly Ser Ser Leu Lys Ala Ile 
                85                  90                  95      


Arg Leu Gly Gln Ser Ala Ile Leu Met Gly Asp Ala Asp Ile Val Leu 
            100                 105                 110         


Val Gly Gly Thr Glu Ser Met Ser Asn Ala Pro Tyr Leu Thr Pro Gln 
        115                 120                 125             


Thr Arg Trp Gly His Lys Phe Gly Asp Ile Thr Leu Thr Asp Ser Leu 
    130                 135                 140                 


Ala His Asp Gly Leu Thr Asp Ala Phe Thr Asp Ile Pro Met Gly Ile 
145                 150                 155                 160 


Thr Ala Glu Asn Val Ala Ala Gln Phe His Ile Ser Arg Ala Asp Gln 
                165                 170                 175     


Asp Ala Phe Ala Leu Arg Ser Gln Arg Arg Ala Thr Ala Ala Gln Gln 
            180                 185                 190         


Ala Asn Arg Phe Ala Asp Glu Ile Val Pro Val Ser Leu Gly Thr Thr 
        195                 200                 205             


Thr Leu Thr Thr Asp Glu Ala Val Arg Thr Thr Thr Ser Arg Glu Gln 
    210                 215                 220                 


Leu Ala Ala Leu Arg Pro Ala Phe Lys Ser Val Gly Thr Val Thr Ala 
225                 230                 235                 240 


Gly Asn Ala Ala Gly Leu Asn Asp Gly Ala Ala Ala Met Ile Leu Met 
                245                 250                 255     


Lys Lys Ser Thr Ala Arg Ala Ala Gly Ile Ala Tyr Leu Ala Thr Leu 
            260                 265                 270         


Arg Gly Tyr Gln Glu Val Gly Ile Asp Pro Ala Ile Met Gly Tyr Ala 
        275                 280                 285             


Pro Val Thr Ala Ile Gln Gln Leu Leu Thr Lys Thr Gln Arg Ser Val 
    290                 295                 300                 


Ser Asp Ile Asp Arg Phe Glu Leu Asn Glu Ala Phe Ala Ala Gln Ser 
305                 310                 315                 320 


Val Ala Val Gly Gln Ala Leu Ala Leu Pro Asp Asp Arg Leu Asn Val 
                325                 330                 335     


Asn Gly Gly Ala Ile Ala Leu Gly His Pro Leu Gly Ala Ser Gly Thr 
            340                 345                 350         


Arg Ile Val Val Thr Leu Leu Tyr Glu Leu Leu His Ser Gly Thr His 
        355                 360                 365             


Leu Gly Val Ala Ser Met Cys Ile Gly Gly Gly Met Gly Met Ala Leu 
    370                 375                 380                 


Met Ile Glu Ser Asn 
385                 


<210>  43
<211>  834
<212>  DNA
<213>  Lactobacillus salvarius

<400>  43
atgtcaagtt tcgttgcgaa cgaagaagaa atccggaact tcttatgtcg tcccaacatg       60

aagaagcagg acggcattat gttcgcatac gttaccagtg ccgaaaagct gactgagctc      120

gtaccaaagc cgctcaaggt tgttgcaccc gttatcatgg gatacgtcac acacatgggc      180

gacccaacat tcgctgcacc atacgacgaa gcggttctgt acgcgttcgt gagttaccag      240

gacaagatca tgggagcata cccattcgtc ttataccttt cgggtgaagg tgctgaagaa      300

gccatgatcg caggtcgtga aggtgcttgt atgccgaaga agttagcaga cgacatcaag      360

atcgagaagt ccgaaaacaa ggtccaggcc aagattatcc ggcacggtac agaaatctta      420

aacttaaagt gggaagcagg tgttccgaac gacgttgaaa ctgtgaagaa gatgttcggc      480

agccaggtca agttaggcga accaagcgaa atggcctcat tcttcatcaa ctacgacatt      540

gaacagcagg acgacggttc taacaagttc gttaacaccg agcttatcgc cacacagagc      600

accggtctaa ctactgacat ggaaattggg aagatcgaca tgaaacttac gagcagcgag      660

gacgacccgc tcgccgaatt agaagttttg aagcctgtag gcggtgcaca ctacaagatg      720

gactactccg tcatgcacaa gacgttgaaa cttgactcac ttaacccgga ggaaattgcc      780

ccatacctta tcacaggtca ctacgaccgt actttcgtta ctaagcagga ctag            834


<210>  44
<211>  277
<212>  PRT
<213>  Lactobacillus salvarius

<400>  44

Met Ser Ser Phe Val Ala Asn Glu Glu Glu Ile Arg Asn Phe Leu Cys 
1               5                   10                  15      


Arg Pro Asn Met Lys Lys Gln Asp Gly Ile Met Phe Ala Tyr Val Thr 
            20                  25                  30          


Ser Ala Glu Lys Leu Thr Glu Leu Val Pro Lys Pro Leu Lys Val Val 
        35                  40                  45              


Ala Pro Val Ile Met Gly Tyr Val Thr His Met Gly Asp Pro Thr Phe 
    50                  55                  60                  


Ala Ala Pro Tyr Asp Glu Ala Val Leu Tyr Ala Phe Val Ser Tyr Gln 
65                  70                  75                  80  


Asp Lys Ile Met Gly Ala Tyr Pro Phe Val Leu Tyr Leu Ser Gly Glu 
                85                  90                  95      


Gly Ala Glu Glu Ala Met Ile Ala Gly Arg Glu Gly Ala Cys Met Pro 
            100                 105                 110         


Lys Lys Leu Ala Asp Asp Ile Lys Ile Glu Lys Ser Glu Asn Lys Val 
        115                 120                 125             


Gln Ala Lys Ile Ile Arg His Gly Thr Glu Ile Leu Asn Leu Lys Trp 
    130                 135                 140                 


Glu Ala Gly Val Pro Asn Asp Val Glu Thr Val Lys Lys Met Phe Gly 
145                 150                 155                 160 


Ser Gln Val Lys Leu Gly Glu Pro Ser Glu Met Ala Ser Phe Phe Ile 
                165                 170                 175     


Asn Tyr Asp Ile Glu Gln Gln Asp Asp Gly Ser Asn Lys Phe Val Asn 
            180                 185                 190         


Thr Glu Leu Ile Ala Thr Gln Ser Thr Gly Leu Thr Thr Asp Met Glu 
        195                 200                 205             


Ile Gly Lys Ile Asp Met Lys Leu Thr Ser Ser Glu Asp Asp Pro Leu 
    210                 215                 220                 


Ala Glu Leu Glu Val Leu Lys Pro Val Gly Gly Ala His Tyr Lys Met 
225                 230                 235                 240 


Asp Tyr Ser Val Met His Lys Thr Leu Lys Leu Asp Ser Leu Asn Pro 
                245                 250                 255     


Glu Glu Ile Ala Pro Tyr Leu Ile Thr Gly His Tyr Asp Arg Thr Phe 
            260                 265                 270         


Val Thr Lys Gln Asp 
        275         


<210>  45
<211>  846
<212>  DNA
<213>  Lactobacillus plantarum

<400>  45
atggctagct tcattgcttc ggaccaggac gtgaagaact tcttaactgc accgtctatg       60

aacgaccaag aaggtattgg attcgcgtac gcgactgacg aggcagttct gaaggctttg      120

attccagcac cgctcaagtt aatggcaccg gttgtttgcg gttacgtcgt acacatggga      180

aaaccgacct tctctgcccc atacttggaa gaatcattgt tcgcattagt gagctacaag      240

gacaaaatga tgggtgcata cccgattaac ttgttacttc atggtccggg tgcagaatca      300

ggtgttattg cagggcgtga aggggcaggt atcccgaaga aactcgctga cgacattgaa      360

cttcgtcgca acgacaacag tgcaactgct actgttgaac gtcacgggaa aaccctcttg      420

aacgtcagtt ggacagctgg agagttgaac gacccgtcga ttatgaaaca attcgcaggt      480

caattagcgc tcggcaagga agctgaaatg aacagtttct tctacaaata cgacattgac      540

cagcacgaag acggcactaa ccacttctct aacgttcaac ttgttgctac gcaattacgt      600

agccttgccg accaagtcga accagggaac ctcagcatcc agttagaatc tacggacgac      660

gacccgttcg gtgagttgaa agtcttaaag cctctgggtg ctgcttggtt ccacttcgac      720

acaagtgtca tgttcaacac gctgaaactc gacgaagttg acgctgcaac tactatgcct      780

aagttattga cgggtcggta cgaccgctca ttcttcaacc caaaagccgc tacttacatt      840

atctag                                                                 846


<210>  46
<211>  281
<212>  PRT
<213>  Lactobacillus plantarum

<400>  46

Met Ala Ser Phe Ile Ala Ser Asp Gln Asp Val Lys Asn Phe Leu Thr 
1               5                   10                  15      


Ala Pro Ser Met Asn Asp Gln Glu Gly Ile Gly Phe Ala Tyr Ala Thr 
            20                  25                  30          


Asp Glu Ala Val Leu Lys Ala Leu Ile Pro Ala Pro Leu Lys Leu Met 
        35                  40                  45              


Ala Pro Val Val Cys Gly Tyr Val Val His Met Gly Lys Pro Thr Phe 
    50                  55                  60                  


Ser Ala Pro Tyr Leu Glu Glu Ser Leu Phe Ala Leu Val Ser Tyr Lys 
65                  70                  75                  80  


Asp Lys Met Met Gly Ala Tyr Pro Ile Asn Leu Leu Leu His Gly Pro 
                85                  90                  95      


Gly Ala Glu Ser Gly Val Ile Ala Gly Arg Glu Gly Ala Gly Ile Pro 
            100                 105                 110         


Lys Lys Leu Ala Asp Asp Ile Glu Leu Arg Arg Asn Asp Asn Ser Ala 
        115                 120                 125             


Thr Ala Thr Val Glu Arg His Gly Lys Thr Leu Leu Asn Val Ser Trp 
    130                 135                 140                 


Thr Ala Gly Glu Leu Asn Asp Pro Ser Ile Met Lys Gln Phe Ala Gly 
145                 150                 155                 160 


Gln Leu Ala Leu Gly Lys Glu Ala Glu Met Asn Ser Phe Phe Tyr Lys 
                165                 170                 175     


Tyr Asp Ile Asp Gln His Glu Asp Gly Thr Asn His Phe Ser Asn Val 
            180                 185                 190         


Gln Leu Val Ala Thr Gln Leu Arg Ser Leu Ala Asp Gln Val Glu Pro 
        195                 200                 205             


Gly Asn Leu Ser Ile Gln Leu Glu Ser Thr Asp Asp Asp Pro Phe Gly 
    210                 215                 220                 


Glu Leu Lys Val Leu Lys Pro Leu Gly Ala Ala Trp Phe His Phe Asp 
225                 230                 235                 240 


Thr Ser Val Met Phe Asn Thr Leu Lys Leu Asp Glu Val Asp Ala Ala 
                245                 250                 255     


Thr Thr Met Pro Lys Leu Leu Thr Gly Arg Tyr Asp Arg Ser Phe Phe 
            260                 265                 270         


Asn Pro Lys Ala Ala Thr Tyr Ile Ile 
        275                 280     


<210>  47
<211>  1071
<212>  DNA
<213>  Lactobacillus fermentum

<400>  47
atgaaaggtt tcgctatgct tggtcccaac aagaccggtt tcattgaaaa agaagatccc       60

aaagttggct cgcgtgatgc tttggttcgt ccgctggcag ttgcgccatg cacaagtgat      120

atccacaccg tattcgaaga tgcattgggt cctcgggaaa acatgatctt agggcacgag      180

gcttgtgggg aaatcgtaga ggttggtagc gaagttaaag atttcaaggt aggcgatcgt      240

gtcctgatcc cagccattac accgaactgg agtgatgtat actctcaagc aggttacgca      300

actgatagcg atggtatgtt gggaggctgg aaattctcca acattaagga tggtgtcttc      360

tcaactcgta ttcacgttaa cgatgcggac ggaaacttag ctttacttcc aaaagagatt      420

gatccggcag aagcctgtat gctgagtgac atgattccga cgggtctgca cgcgtttgaa      480

atggcaggag ttaccttcgg ggacgccgtg gccgtgattg gcgtgggtcc agttggtctc      540

atggctttac gtggggctgt tttacatggg gctggacgcg tattcgcggt tggttcacgg      600

gagaaaacag tagaagtggc gaagaagtat ggtgccaccg acatcattga ctaccacaac      660

ggtcgcatta gcgaccaaat tctggaagcc acaaacggtc aaggtgttga taaagtattg      720

attgcagggg gtaacgccaa agatactttc gaagaagctg tgcggatgct caaaccgggt      780

ggtagcatcg gaaacgtcaa ctacctaaac ggtcacgatg atgttgtttt caacgcaggt      840

gactggggtg ttggtatggg ccacaaaaca attcacggtg gcctcatgcc aggtggccgt      900

ttgcgtatgg aaaagttagc cgcattggta gtgaatggtc ggattgaccc ctcgctgatg      960

attacacacc gtttcgaagg cttcgagaaa atccctgatg ccatcgagct catgcaccac     1020

aaaccagctg atttgatcaa accggttgtc atttgtaacg atattgatta g              1071


<210>  48
<211>  356
<212>  PRT
<213>  Lactobacillus fermentum

<400>  48

Met Lys Gly Phe Ala Met Leu Gly Pro Asn Lys Thr Gly Phe Ile Glu 
1               5                   10                  15      


Lys Glu Asp Pro Lys Val Gly Ser Arg Asp Ala Leu Val Arg Pro Leu 
            20                  25                  30          


Ala Val Ala Pro Cys Thr Ser Asp Ile His Thr Val Phe Glu Asp Ala 
        35                  40                  45              


Leu Gly Pro Arg Glu Asn Met Ile Leu Gly His Glu Ala Cys Gly Glu 
    50                  55                  60                  


Ile Val Glu Val Gly Ser Glu Val Lys Asp Phe Lys Val Gly Asp Arg 
65                  70                  75                  80  


Val Leu Ile Pro Ala Ile Thr Pro Asn Trp Ser Asp Val Tyr Ser Gln 
                85                  90                  95      


Ala Gly Tyr Ala Thr Asp Ser Asp Gly Met Leu Gly Gly Trp Lys Phe 
            100                 105                 110         


Ser Asn Ile Lys Asp Gly Val Phe Ser Thr Arg Ile His Val Asn Asp 
        115                 120                 125             


Ala Asp Gly Asn Leu Ala Leu Leu Pro Lys Glu Ile Asp Pro Ala Glu 
    130                 135                 140                 


Ala Cys Met Leu Ser Asp Met Ile Pro Thr Gly Leu His Ala Phe Glu 
145                 150                 155                 160 


Met Ala Gly Val Thr Phe Gly Asp Ala Val Ala Val Ile Gly Val Gly 
                165                 170                 175     


Pro Val Gly Leu Met Ala Leu Arg Gly Ala Val Leu His Gly Ala Gly 
            180                 185                 190         


Arg Val Phe Ala Val Gly Ser Arg Glu Lys Thr Val Glu Val Ala Lys 
        195                 200                 205             


Lys Tyr Gly Ala Thr Asp Ile Ile Asp Tyr His Asn Gly Arg Ile Ser 
    210                 215                 220                 


Asp Gln Ile Leu Glu Ala Thr Asn Gly Gln Gly Val Asp Lys Val Leu 
225                 230                 235                 240 


Ile Ala Gly Gly Asn Ala Lys Asp Thr Phe Glu Glu Ala Val Arg Met 
                245                 250                 255     


Leu Lys Pro Gly Gly Ser Ile Gly Asn Val Asn Tyr Leu Asn Gly His 
            260                 265                 270         


Asp Asp Val Val Phe Asn Ala Gly Asp Trp Gly Val Gly Met Gly His 
        275                 280                 285             


Lys Thr Ile His Gly Gly Leu Met Pro Gly Gly Arg Leu Arg Met Glu 
    290                 295                 300                 


Lys Leu Ala Ala Leu Val Val Asn Gly Arg Ile Asp Pro Ser Leu Met 
305                 310                 315                 320 


Ile Thr His Arg Phe Glu Gly Phe Glu Lys Ile Pro Asp Ala Ile Glu 
                325                 330                 335     


Leu Met His His Lys Pro Ala Asp Leu Ile Lys Pro Val Val Ile Cys 
            340                 345                 350         


Asn Asp Ile Asp 
        355     


<210>  49
<211>  182
<212>  DNA
<213>  E. coli

<400>  49
aagcttatcg atagcgctat agttgttgac agaatggaca tactatgata tattgttgct       60

atagcgtact tagctggcca gcatatatgt attctataaa atactattac aaggagattt      120

tagccatgga attcgcatgc ggatccgcgg ccgcggtacc cgggcgcgcc tctagaaagc      180

tt                                                                     182


<210>  50
<211>  182
<212>  DNA
<213>  E. coli

<400>  50
aagcttatcg atcggggttt agttgttgac agggaggctt cgttgtgata agatggtagt       60

atagcgtact tagctggcca gcatatatgt attctataaa atactattac aaggagattt      120

tagccatgga attcgcatgc ggatccgcgg ccgcggtacc cgggcgcgcc tctagaaagc      180

tt                                                                     182


<210>  51
<211>  35
<212>  DNA
<213>  Lactobacillus reuteri

<400>  51
agtcaagctt ccatggagaa ggtttacatt gttgc                                  35


<210>  52
<211>  51
<212>  DNA
<213>  Lactobacillus reuteri

<400>  52
atgcggtacc gaattcctcg agtctagact aaattttctt aagcagaacc g                51


<210>  53
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  ARTIFICIAL PRIMER

<400>  53
tagtctagac tcgaggaatt cggtacc                                           27


<210>  54
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  ARTIFICIAL PRIMER

<400>  54
aagcttctcg agactattac aaggagattt tagcc                                  35


<210>  55
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  ARTIFICIAL PRIMER

<400>  55
gaattcacta ttacaaggag attttagtc                                         29


<210>  56
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  ARTIFICIAL PRIMER

<400>  56
aagcttctcg agactattac aaggagattt tagtc                                  35


<210>  57
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  ARTIFICIAL PRIMER

<400>  57
aagcttcggc cgactattac aaggagattt tagcc                                  35


<210>  58
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  ARTIFICIAL PRIMER

<400>  58
ggtaccacta ttacaaggag attttagtc                                         29


<210>  59
<211>  1197
<212>  DNA
<213>  Lactobacillus reuteri

<400>  59
atgtcaaaaa caattgcagt taacgctggt agttcaacac ttaaattcaa attatttgat       60

atgccaagtg aagatgtagt agctgaaggt acgattgaac gtattggtga aaagatgggt      120

catgctaaga ttaagtatgg taatggtcaa aagcatgaag aagataagcc atttgctgat      180

catgctgccg cagttaatta cttgttagac aagttaattg aattaaagat tgtggcaagc      240

tatgatgaaa tcacagcagt aggtcaccga atcgttgccg gtggagaatt ctttaaggat      300

tcaacaatta ttgatgatga tgttattagc aaaattgatg aattgtcaga atatgctcca      360

ctccatgagc ctgcagaatt agttggtatt aaagccttcc gtaaagtatt gcctaatgca      420

tttgcggttg ctgtttttga tacatcattc catgttgata tgccagaaat gaatgcattg      480

tacagtgtgc cttatgattg gtatgagaag tatggtgctc gtaagtacgg tgctcacggt      540

accagtcacc gttatgtatc tgcacgtgct gcggaaatgt taggaaagcc aattgaagag      600

cttaaattaa tcaccatgca tattggagca ggtgcgtcaa tcactgccgt aaagaatggt      660

aagtcattcg atacatcaat gggcttcaca cctgttgcgg gaataacaat ggcaactcgt      720

tcaggggatg ttgatccatc cttaattgct tttatgcagg gtaaactaaa cttatcctca      780

gatgagatga ttgatatttt gaaccataag tctggtttac ttggtatttc tggtatctca      840

ccagatatgc gtgatattct tgcagctgct gaaaagggtg acgagcgagc acaacttgca      900

ttagatattt atgttaaccg cattgtccgt tacattggag catacattgc ggagatgggt      960

ggcgctgatg ccattgtctt cactgctggt gttggtgaaa acagtgttcc agtacgaaag     1020

atgatcacag ataagcttga ctactttggt attaagattg atcaagaaaa gaacaattgc     1080

catggtgttg aacgtgacct ttccgccgat gatgcaaaga ttaagacatt gttaattcca     1140

actaacgaag aattaatgat tgttcgtgac attgaacgct taaagaaaaa taactaa        1197


<210>  60
<211>  398
<212>  PRT
<213>  Lactobacillus reuteri

<400>  60

Met Ser Lys Thr Ile Ala Val Asn Ala Gly Ser Ser Thr Leu Lys Phe 
1               5                   10                  15      


Lys Leu Phe Asp Met Pro Ser Glu Asp Val Val Ala Glu Gly Thr Ile 
            20                  25                  30          


Glu Arg Ile Gly Glu Lys Met Gly His Ala Lys Ile Lys Tyr Gly Asn 
        35                  40                  45              


Gly Gln Lys His Glu Glu Asp Lys Pro Phe Ala Asp His Ala Ala Ala 
    50                  55                  60                  


Val Asn Tyr Leu Leu Asp Lys Leu Ile Glu Leu Lys Ile Val Ala Ser 
65                  70                  75                  80  


Tyr Asp Glu Ile Thr Ala Val Gly His Arg Ile Val Ala Gly Gly Glu 
                85                  90                  95      


Phe Phe Lys Asp Ser Thr Ile Ile Asp Asp Asp Val Ile Ser Lys Ile 
            100                 105                 110         


Asp Glu Leu Ser Glu Tyr Ala Pro Leu His Glu Pro Ala Glu Leu Val 
        115                 120                 125             


Gly Ile Lys Ala Phe Arg Lys Val Leu Pro Asn Ala Phe Ala Val Ala 
    130                 135                 140                 


Val Phe Asp Thr Ser Phe His Val Asp Met Pro Glu Met Asn Ala Leu 
145                 150                 155                 160 


Tyr Ser Val Pro Tyr Asp Trp Tyr Glu Lys Tyr Gly Ala Arg Lys Tyr 
                165                 170                 175     


Gly Ala His Gly Thr Ser His Arg Tyr Val Ser Ala Arg Ala Ala Glu 
            180                 185                 190         


Met Leu Gly Lys Pro Ile Glu Glu Leu Lys Leu Ile Thr Met His Ile 
        195                 200                 205             


Gly Ala Gly Ala Ser Ile Thr Ala Val Lys Asn Gly Lys Ser Phe Asp 
    210                 215                 220                 


Thr Ser Met Gly Phe Thr Pro Val Ala Gly Ile Thr Met Ala Thr Arg 
225                 230                 235                 240 


Ser Gly Asp Val Asp Pro Ser Leu Ile Ala Phe Met Gln Gly Lys Leu 
                245                 250                 255     


Asn Leu Ser Ser Asp Glu Met Ile Asp Ile Leu Asn His Lys Ser Gly 
            260                 265                 270         


Leu Leu Gly Ile Ser Gly Ile Ser Pro Asp Met Arg Asp Ile Leu Ala 
        275                 280                 285             


Ala Ala Glu Lys Gly Asp Glu Arg Ala Gln Leu Ala Leu Asp Ile Tyr 
    290                 295                 300                 


Val Asn Arg Ile Val Arg Tyr Ile Gly Ala Tyr Ile Ala Glu Met Gly 
305                 310                 315                 320 


Gly Ala Asp Ala Ile Val Phe Thr Ala Gly Val Gly Glu Asn Ser Val 
                325                 330                 335     


Pro Val Arg Lys Met Ile Thr Asp Lys Leu Asp Tyr Phe Gly Ile Lys 
            340                 345                 350         


Ile Asp Gln Glu Lys Asn Asn Cys His Gly Val Glu Arg Asp Leu Ser 
        355                 360                 365             


Ala Asp Asp Ala Lys Ile Lys Thr Leu Leu Ile Pro Thr Asn Glu Glu 
    370                 375                 380                 


Leu Met Ile Val Arg Asp Ile Glu Arg Leu Lys Lys Asn Asn 
385                 390                 395             


<210>  61
<211>  385
<212>  PRT
<213>  Lactobacillus reuteri

<400>  61

Met Arg Ile Gly Ile Asp Lys Met Ala Phe Ala Thr Thr Asn Asp Tyr 
1               5                   10                  15      


Leu Asp Leu Val Glu Leu Ala Lys Glu Arg Gly Val Asp Pro Asn Lys 
            20                  25                  30          


Phe Thr Ile Gly Ile Gly Gln Asp Leu Gln Ala Val Val Pro Pro Thr 
        35                  40                  45              


Gln Asp Ile Val Thr Leu Gly Ala Thr Ala Ala Lys Lys Leu Leu Thr 
    50                  55                  60                  


Pro Glu Leu Glu Lys Asn Ile Ser Thr Val Ile Val Ala Thr Glu Ser 
65                  70                  75                  80  


Gly Ile Asp Asn Ser Lys Ala Ser Ala Ile Tyr Ile Lys His Leu Leu 
                85                  90                  95      


Gly Leu Ser Asp Phe Ile Arg Thr Val Glu Met Lys Glu Ala Cys Tyr 
            100                 105                 110         


Ser Ala Thr Ala Ala Ile Gln Phe Ala Lys Gly Val Val Ala Leu Asn 
        115                 120                 125             


Pro Gln Glu Thr Val Leu Val Ile Ala Ala Asp Ile Ala Arg Tyr Gly 
    130                 135                 140                 


Leu Asn Thr Pro Gly Glu Val Thr Gln Gly Ala Gly Ala Val Ala Met 
145                 150                 155                 160 


Leu Ile Ser Arg Asn Pro His Ile Leu Thr Leu Glu Asp Thr Thr Val 
                165                 170                 175     


Ala Tyr Ser Lys Asp Ile Met Asp Phe Trp Arg Pro Leu Tyr Ala Thr 
            180                 185                 190         


Glu Ala Leu Val Asp Gly Lys Tyr Ser Thr Asn Val Tyr Ile Glu Phe 
        195                 200                 205             


Phe Leu Gln Thr Phe Thr Arg Tyr Gln Gln Leu Thr Gly Arg Glu Leu 
    210                 215                 220                 


Ala Asp Phe Ala Ala Leu Thr Phe His Met Pro Phe Thr Lys Met Gly 
225                 230                 235                 240 


Lys Lys Gly Leu Glu Gly Leu Leu Lys Asp Arg Asn Asp Glu Val Ala 
                245                 250                 255     


Gln Arg Leu Arg Thr Gln Leu Thr Ala Ser Gln Leu Phe Ser Arg Gln 
            260                 265                 270         


Val Gly Asn Leu Tyr Thr Gly Ser Leu Tyr Leu Ser Leu Met Ser Leu 
        275                 280                 285             


Leu Gln Asn Ser Asp Leu Arg Ala Glu Ser Arg Ile Gly Leu Phe Ser 
    290                 295                 300                 


Tyr Gly Ser Gly Ala Glu Gly Glu Phe Tyr Thr Gly Ile Leu Glu Asp 
305                 310                 315                 320 


Gly Tyr Glu His Tyr Met Asn Asn Ile Gln Glu Glu Leu Lys His Arg 
                325                 330                 335     


His Gln Val Ser Val Ala Glu Tyr Glu Lys Leu Phe Ser Ser Gln Leu 
            340                 345                 350         


Gly Met Asn Asp Arg Asp Ile Glu Phe Asp Val Thr Thr Asp Pro Leu 
        355                 360                 365             


Pro Phe Val Leu Lys Gly Gln Lys Asp His Gln Arg Ile Tyr Glu Ala 
    370                 375                 380                 


Lys 
385 


<210>  62
<211>  415
<212>  PRT
<213>  Bacillus amyloliquefaciens

<400>  62

Met Asn Val Gly Ile Glu Ala Met Asn Val Phe Gly Gly Thr Ala Tyr 
1               5                   10                  15      


Val Asp Val Met Glu Leu Ala Glu His Arg Asn Leu Asp Lys Lys Arg 
            20                  25                  30          


Phe Glu Asn Leu Leu Met Lys Glu Lys Val Val Ala Leu Pro Phe Glu 
        35                  40                  45              


Asp Pro Ile Thr Phe Ala Val Asn Ala Ala Lys Pro Ile Ile Asp Ser 
    50                  55                  60                  


Leu Ser Glu Glu Glu Arg Asn Gln Ile Glu Met Val Ile Thr Cys Thr 
65                  70                  75                  80  


Glu Ser Gly Ile Asp Phe Gly Lys Ser Ile Ser Thr Tyr Val His Asp 
                85                  90                  95      


Tyr Leu Gln Leu Lys Arg Asn Cys Arg Leu Phe Glu Val Lys Gln Ala 
            100                 105                 110         


Cys Tyr Ser Leu Thr Ala Gly Phe Gln Met Gly Val Asn Phe Ile Leu 
        115                 120                 125             


Ser Gln Thr Ser Pro Gly Ala Lys Ala Leu Ile Ile Gly Thr Asp Ile 
    130                 135                 140                 


Ser Arg Phe Leu Val Ala Glu Gly Gly Asp Ala Leu Thr Glu Glu Trp 
145                 150                 155                 160 


Ser Tyr Ala Glu Pro Ser Ala Gly Ala Gly Ala Val Ala Leu Leu Val 
                165                 170                 175     


Ser Ser Thr Pro His Val Phe Leu Leu Asp Gln Gly Ala Ser Gly Tyr 
            180                 185                 190         


Tyr Gly Tyr Glu Val Met Asp Thr Cys Arg Pro Ile Pro Asp Ser Glu 
        195                 200                 205             


Ala Gly Asp Ala Asp Leu Ser Leu Met Ser Tyr Leu Asp Cys Cys Glu 
    210                 215                 220                 


Lys Ser Phe Gln Glu Tyr Arg Lys Arg Val Ser Gly Ala Asp Tyr Lys 
225                 230                 235                 240 


Asn Thr Phe Gln Tyr Leu Ser Phe His Thr Pro Phe Gly Gly Met Val 
                245                 250                 255     


Lys Gly Ala His Arg Thr Met Met Arg Lys Leu Ala Lys Ala Lys Pro 
            260                 265                 270         


Gln Asp Ile Glu Ala Asp Phe Gln Gln Arg Val Leu Pro Gly Ile Gln 
        275                 280                 285             


Tyr Cys Gln Arg Val Gly Asn Ile Met Gly Ala Thr Val Phe Leu Ser 
    290                 295                 300                 


Leu Ala Ser Thr Ile Asp Asn Gly Ser Phe Glu Thr Pro Lys Arg Val 
305                 310                 315                 320 


Gly Cys Phe Ser Tyr Gly Ser Gly Cys Cys Ser Glu Phe Tyr Ser Gly 
                325                 330                 335     


Val Val Met Pro Gln Ser Arg Thr Arg Gln Asn Gln Phe Gln Ile Ser 
            340                 345                 350         


Arg His Leu Asp Glu Arg Val Arg Leu Ser Met Ala Asp Tyr Asp Arg 
        355                 360                 365             


Leu Leu Gln Asp Ser Gly Ile Val Lys Phe Gly Thr Arg Asn Ala Ala 
    370                 375                 380                 


Pro Ala Ala Asp Ile Pro Asn Ala His Gln Gly Lys Thr Arg Leu Val 
385                 390                 395                 400 


Leu Ala Glu Ile Lys Glu Phe His Arg Lys Tyr Glu Trp Thr Thr 
                405                 410                 415 


<210>  63
<211>  420
<212>  PRT
<213>  Bacillus amyloliquefaciens

<400>  63

Met Ala Ala Ala Gly Ile Glu Ala Ile Asn Val Phe Gly Gly Thr Ala 
1               5                   10                  15      


Tyr Leu Asp Val Met Gln Leu Ala Glu Tyr Arg Asn Leu Asp Pro Ala 
            20                  25                  30          


Arg Phe Glu Asn Leu Leu Met Lys Glu Lys Ala Val Ala Leu Pro Tyr 
        35                  40                  45              


Glu Asp Pro Val Thr Phe Gly Val Asn Ala Ala Lys Pro Ile Ile Asp 
    50                  55                  60                  


Arg Leu Thr Glu Ala Glu Lys Asp Arg Ile Glu Leu Leu Ile Thr Cys 
65                  70                  75                  80  


Ser Glu Ser Gly Ile Asp Phe Gly Lys Ser Leu Ser Thr Tyr Ile His 
                85                  90                  95      


Asp Tyr Leu Gly Leu Asn Arg Asn Cys Arg Leu Phe Glu Leu Lys Gln 
            100                 105                 110         


Ala Cys Tyr Ser Gly Thr Ala Gly Leu Gln Met Ala Leu Asn Phe Ile 
        115                 120                 125             


Leu Ser Gln Thr Ser Pro Gly Ala Lys Ala Leu Val Val Ala Thr Asp 
    130                 135                 140                 


Ile Ser Arg Phe Leu Ile Ala Glu Gly Gly Asp Ala Leu Ser Glu Asp 
145                 150                 155                 160 


Trp Ser Tyr Ala Glu Pro Ser Ala Gly Ala Gly Ala Val Ala Leu Leu 
                165                 170                 175     


Ile Gly Glu Asn Pro Ile Val Phe Gln Ala Asp Ala Gly Ala Asn Gly 
            180                 185                 190         


Tyr Tyr Gly Tyr Glu Val Met Asp Thr Cys Arg Pro Ile Pro Asp Ser 
        195                 200                 205             


Glu Ala Gly Asp Ala Asp Leu Ser Leu Met Ser Tyr Leu Asp Cys Cys 
    210                 215                 220                 


Glu Gln Thr Phe Arg Glu Tyr Lys Asn Arg Val Pro Gly Ala Asp Tyr 
225                 230                 235                 240 


Lys Glu Thr Phe His Tyr Leu Ala Phe His Thr Pro Phe Gly Gly Met 
                245                 250                 255     


Val Lys Gly Ala His Arg Thr Met Met Arg Lys Leu Ala Lys Ala Lys 
            260                 265                 270         


Asn Ala Glu Ile Glu Gln Asp Phe Gln Thr Arg Val Glu Pro Gly Leu 
        275                 280                 285             


Arg Tyr Cys Gln Arg Val Gly Asn Ile Met Gly Ala Ala Ser Leu Leu 
    290                 295                 300                 


Ala Leu Ala Ser Thr Ile Asp Gln Gly Ala Phe Asp Thr Ser Lys Arg 
305                 310                 315                 320 


Ile Gly Cys Phe Ser Tyr Gly Ser Gly Cys Cys Ser Glu Phe Tyr Ser 
                325                 330                 335     


Gly Val Val Thr Pro Glu Gly Gln Thr Arg Gln His Ser Phe Lys Ile 
            340                 345                 350         


Glu Glu His Leu Asn Asn Arg Tyr Arg Leu Ser Met Glu Glu Tyr Glu 
        355                 360                 365             


Glu Leu Phe Lys Gly Ser Gly Leu Val Lys Phe Gly Thr Arg Asn Val 
    370                 375                 380                 


Lys Leu Asp Met Asn Met Ile Pro Asn Ile Leu Asp His His Ala Gly 
385                 390                 395                 400 


Ser Pro Arg Leu Tyr Leu Glu Glu Ile Thr Glu Phe His Arg Lys Tyr 
                405                 410                 415     


Arg Trp Ile Ser 
            420 


<210>  64
<211>  491
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  64

Met Lys Leu Ser Thr Lys Leu Cys Trp Cys Gly Ile Lys Gly Arg Leu 
1               5                   10                  15      


Arg Pro Gln Lys Gln Gln Gln Leu His Asn Thr Asn Leu Gln Met Thr 
            20                  25                  30          


Glu Leu Lys Lys Gln Lys Thr Ala Glu Gln Lys Thr Arg Pro Gln Asn 
        35                  40                  45              


Val Gly Ile Lys Gly Ile Gln Ile Tyr Ile Pro Thr Gln Cys Val Asn 
    50                  55                  60                  


Gln Ser Glu Leu Glu Lys Phe Asp Gly Val Ser Gln Gly Lys Tyr Thr 
65                  70                  75                  80  


Ile Gly Leu Gly Gln Thr Asn Met Ser Phe Val Asn Asp Arg Glu Asp 
                85                  90                  95      


Ile Tyr Ser Met Ser Leu Thr Val Leu Ser Lys Leu Ile Lys Ser Tyr 
            100                 105                 110         


Asn Ile Asp Thr Asn Lys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
        115                 120                 125             


Leu Ile Asp Lys Ser Lys Ser Val Lys Ser Val Leu Met Gln Leu Phe 
    130                 135                 140                 


Gly Glu Asn Thr Asp Val Glu Gly Ile Asp Thr Leu Asn Ala Cys Tyr 
145                 150                 155                 160 


Gly Gly Thr Asn Ala Leu Phe Asn Ser Leu Asn Trp Ile Glu Ser Asn 
                165                 170                 175     


Ala Trp Asp Gly Arg Asp Ala Ile Val Val Cys Gly Asp Ile Ala Ile 
            180                 185                 190         


Tyr Asp Lys Gly Ala Ala Arg Pro Thr Gly Gly Ala Gly Thr Val Ala 
        195                 200                 205             


Met Trp Ile Gly Pro Asp Ala Pro Ile Val Phe Asp Ser Val Arg Ala 
    210                 215                 220                 


Ser Tyr Met Glu His Ala Tyr Asp Phe Tyr Lys Pro Asp Phe Thr Ser 
225                 230                 235                 240 


Glu Tyr Pro Tyr Val Asp Gly His Phe Ser Leu Thr Cys Tyr Val Lys 
                245                 250                 255     


Ala Leu Asp Gln Val Tyr Lys Ser Tyr Ser Lys Lys Ala Ile Ser Lys 
            260                 265                 270         


Gly Leu Val Ser Asp Pro Ala Gly Ser Asp Ala Leu Asn Val Leu Lys 
        275                 280                 285             


Tyr Phe Asp Tyr Asn Val Phe His Val Pro Thr Cys Lys Leu Val Thr 
    290                 295                 300                 


Lys Ser Tyr Gly Arg Leu Leu Tyr Asn Asp Phe Arg Ala Asn Pro Gln 
305                 310                 315                 320 


Leu Phe Pro Glu Val Asp Ala Glu Leu Ala Thr Arg Asp Tyr Asp Glu 
                325                 330                 335     


Ser Leu Thr Asp Lys Asn Ile Glu Lys Thr Phe Val Asn Val Ala Lys 
            340                 345                 350         


Pro Phe His Lys Glu Arg Val Ala Gln Ser Leu Ile Val Pro Thr Asn 
        355                 360                 365             


Thr Gly Asn Met Tyr Thr Ala Ser Val Tyr Ala Ala Phe Ala Ser Leu 
    370                 375                 380                 


Leu Asn Tyr Val Gly Ser Asp Asp Leu Gln Gly Lys Arg Val Gly Leu 
385                 390                 395                 400 


Phe Ser Tyr Gly Ser Gly Leu Ala Ala Ser Leu Tyr Ser Cys Lys Ile 
                405                 410                 415     


Val Gly Asp Val Gln His Ile Ile Lys Glu Leu Asp Ile Thr Asn Lys 
            420                 425                 430         


Leu Ala Lys Arg Ile Thr Glu Thr Pro Lys Asp Tyr Glu Ala Ala Ile 
        435                 440                 445             


Glu Leu Arg Glu Asn Ala His Leu Lys Lys Asn Phe Lys Pro Gln Gly 
    450                 455                 460                 


Ser Ile Glu His Leu Gln Ser Gly Val Tyr Tyr Leu Thr Asn Ile Asp 
465                 470                 475                 480 


Asp Lys Phe Arg Arg Ser Tyr Asp Val Lys Lys 
                485                 490     


<210>  65
<211>  447
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  65

Met Ser Phe Asp Arg Lys Asp Ile Gly Ile Lys Gly Leu Val Leu Tyr 
1               5                   10                  15      


Thr Pro Asn Gln Tyr Val Glu Gln Ala Ala Leu Glu Ala His Asp Gly 
            20                  25                  30          


Val Ser Thr Gly Lys Tyr Thr Ile Gly Leu Gly Leu Thr Lys Met Ala 
        35                  40                  45              


Phe Val Asp Asp Arg Glu Asp Ile Tyr Ser Phe Gly Leu Thr Ala Leu 
    50                  55                  60                  


Ser Gln Leu Ile Lys Arg Tyr Gln Ile Asp Ile Ser Lys Ile Gly Arg 
65                  70                  75                  80  


Leu Glu Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ser Val Lys 
                85                  90                  95      


Ser Val Leu Met Gln Leu Phe Gly Asp Asn His Asn Val Glu Gly Ile 
            100                 105                 110         


Asp Cys Val Asn Ala Cys Tyr Gly Gly Val Asn Ala Leu Phe Asn Thr 
        115                 120                 125             


Ile Asp Trp Ile Glu Ser Ser Ala Trp Asp Gly Arg Asp Gly Ile Val 
    130                 135                 140                 


Val Ala Gly Asp Ile Ala Leu Tyr Ala Lys Gly Asn Ala Arg Pro Thr 
145                 150                 155                 160 


Gly Gly Ala Gly Cys Val Ala Leu Leu Val Gly Pro Asn Ala Pro Ile 
                165                 170                 175     


Val Phe Glu Pro Gly Leu Arg Gly Thr Tyr Met Gln His Ala Tyr Asp 
            180                 185                 190         


Phe Tyr Lys Pro Asp Leu Thr Ser Glu Tyr Pro Tyr Val Asp Gly His 
        195                 200                 205             


Phe Ser Leu Glu Cys Tyr Val Lys Ala Leu Asp Gly Ala Tyr Ala Asn 
    210                 215                 220                 


Tyr Asn Val Arg Asp Val Ala Lys Asn Gly Lys Ser Gln Gly Leu Gly 
225                 230                 235                 240 


Leu Asp Arg Phe Asp Tyr Cys Ile Phe His Ala Pro Thr Cys Lys Gln 
                245                 250                 255     


Val Gln Lys Ala Tyr Ala Arg Leu Leu Tyr Thr Asp Ser Ala Ala Glu 
            260                 265                 270         


Pro Ser Asn Pro Glu Leu Glu Gly Val Arg Glu Leu Leu Ser Thr Leu 
        275                 280                 285             


Asp Ala Lys Lys Ser Leu Thr Asp Lys Ala Leu Glu Lys Gly Leu Met 
    290                 295                 300                 


Ala Ile Thr Lys Glu Arg Phe Asn Lys Arg Val Ser Pro Ser Val Tyr 
305                 310                 315                 320 


Ala Pro Thr Asn Cys Gly Asn Met Tyr Thr Ala Ser Ile Phe Ser Cys 
                325                 330                 335     


Leu Thr Ala Leu Leu Ser Arg Val Pro Ala Asp Glu Leu Lys Gly Lys 
            340                 345                 350         


Arg Val Gly Ala Tyr Ser Tyr Gly Ser Gly Leu Ala Ala Ser Phe Phe 
        355                 360                 365             


Ser Phe Val Val Lys Gly Asp Val Ser Glu Ile Ala Lys Lys Thr Asn 
    370                 375                 380                 


Leu Val Asn Asp Leu Asp Asn Arg His Cys Leu Thr Pro Thr Gln Tyr 
385                 390                 395                 400 


Glu Glu Ala Ile Glu Leu Arg His Gln Ala His Leu Lys Lys Asn Phe 
                405                 410                 415     


Thr Pro Lys Gly Ser Ile Glu Arg Leu Arg Ser Gly Thr Tyr Tyr Leu 
            420                 425                 430         


Thr Gly Ile Asp Asp Met Phe Arg Arg Ser Tyr Ser Val Lys Pro 
        435                 440                 445         


<210>  66
<211>  461
<212>  PRT
<213>  Arabidopsis thaliana

<400>  66

Met Ala Lys Asn Val Gly Ile Leu Ala Met Asp Ile Tyr Phe Pro Pro 
1               5                   10                  15      


Thr Cys Val Gln Gln Glu Ala Leu Glu Ala His Asp Gly Ala Ser Lys 
            20                  25                  30          


Gly Lys Tyr Thr Ile Gly Leu Gly Gln Asp Cys Leu Ala Phe Cys Thr 
        35                  40                  45              


Glu Leu Glu Asp Val Ile Ser Met Ser Phe Asn Ala Val Thr Ser Leu 
    50                  55                  60                  


Phe Glu Lys Tyr Lys Ile Asp Pro Asn Gln Ile Gly Arg Leu Glu Val 
65                  70                  75                  80  


Gly Ser Glu Thr Val Ile Asp Lys Ser Lys Ser Ile Lys Thr Phe Leu 
                85                  90                  95      


Met Gln Leu Phe Glu Lys Cys Gly Asn Thr Asp Val Glu Gly Val Asp 
            100                 105                 110         


Ser Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ala Leu Leu Asn Cys Val 
        115                 120                 125             


Asn Trp Val Glu Ser Asn Ser Trp Asp Gly Arg Tyr Gly Leu Val Ile 
    130                 135                 140                 


Cys Thr Asp Ser Ala Val Tyr Ala Glu Gly Pro Ala Arg Pro Thr Gly 
145                 150                 155                 160 


Gly Ala Ala Ala Ile Ala Met Leu Ile Gly Pro Asp Ala Pro Ile Val 
                165                 170                 175     


Phe Glu Ser Lys Leu Arg Ala Ser His Met Ala His Val Tyr Asp Phe 
            180                 185                 190         


Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Val Val Asp Gly Lys Leu 
        195                 200                 205             


Ser Gln Thr Cys Tyr Leu Met Ala Leu Asp Ser Cys Tyr Lys His Leu 
    210                 215                 220                 


Cys Asn Lys Phe Glu Lys Ile Glu Gly Lys Glu Phe Ser Ile Asn Asp 
225                 230                 235                 240 


Ala Asp Tyr Ile Val Phe His Ser Pro Tyr Asn Lys Leu Val Gln Lys 
                245                 250                 255     


Ser Phe Ala Arg Leu Leu Tyr Asn Asp Phe Leu Arg Asn Ala Ser Ser 
            260                 265                 270         


Ile Asp Glu Ala Ala Lys Glu Lys Phe Thr Pro Tyr Ser Ser Leu Thr 
        275                 280                 285             


Leu Asp Glu Ser Tyr Gln Ser Arg Asp Leu Glu Lys Val Ser Gln Gln 
    290                 295                 300                 


Ile Ala Lys Pro Phe Tyr Asp Ala Lys Val Gln Pro Thr Thr Leu Ile 
305                 310                 315                 320 


Pro Lys Glu Val Gly Asn Met Tyr Thr Ala Ser Leu Tyr Ala Ala Phe 
                325                 330                 335     


Ala Ser Leu Ile His Lys Lys His Asn Asp Leu Ala Gly Lys Arg Val 
            340                 345                 350         


Val Met Phe Ser Tyr Gly Ser Gly Ser Thr Ala Thr Met Phe Ser Leu 
        355                 360                 365             


Arg Leu Asn Asp Asn Lys Pro Pro Phe Ser Ile Ser Asn Ile Ala Ser 
    370                 375                 380                 


Val Met Asp Val Gly Gly Lys Leu Lys Ala Arg His Glu Tyr Ala Pro 
385                 390                 395                 400 


Glu Lys Phe Val Glu Thr Met Lys Leu Met Glu His Arg Tyr Gly Ala 
                405                 410                 415     


Lys Asp Phe Val Thr Thr Lys Glu Gly Ile Ile Asp Leu Leu Ala Pro 
            420                 425                 430         


Gly Thr Tyr Tyr Leu Lys Glu Val Asp Ser Leu Tyr Arg Arg Phe Tyr 
        435                 440                 445             


Gly Lys Lys Gly Glu Asp Gly Ser Val Ala Asn Gly His 
    450                 455                 460     


<210>  67
<211>  453
<212>  PRT
<213>  Blattella germanica

<400>  67

Met Trp Pro Ser Asp Val Gly Ile Val Ala Leu Glu Leu Ile Phe Pro 
1               5                   10                  15      


Ser Gln Tyr Val Asp Gln Val Asp Leu Glu Val Tyr Asp Asn Val Ser 
            20                  25                  30          


Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Ala Arg Met Gly Phe Cys 
        35                  40                  45              


Thr Asp Arg Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Ser Arg 
    50                  55                  60                  


Leu Met Glu Arg Trp Ser Ile Pro Tyr Ser Gln Ile Gly Arg Leu Glu 
65                  70                  75                  80  


Val Gly Thr Glu Thr Leu Leu Asp Lys Ser Lys Ser Val Lys Thr Val 
                85                  90                  95      


Leu Met Gln Leu Phe Lys Asp Asn Thr Asp Ile Glu Gly Val Asp Thr 
            100                 105                 110         


Val Asn Ala Cys Tyr Gly Gly Thr Ser Ala Leu Phe Asn Ala Ile Ser 
        115                 120                 125             


Trp Val Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala 
    130                 135                 140                 


Gly Asp Ile Ala Val Tyr Ala Lys Gly Ser Ala Arg Pro Thr Gly Gly 
145                 150                 155                 160 


Ala Gly Ala Val Ala Met Leu Val Gly Ala Asn Ala Pro Leu Val Phe 
                165                 170                 175     


Asp Arg Gly Val Arg Ser Ser His Met Gln His Ala Tyr Asp Phe Tyr 
            180                 185                 190         


Lys Pro Asp Leu Ser Ser Leu Tyr Pro Thr Val Asp Gly Lys Leu Ser 
        195                 200                 205             


Ile Gln Cys Tyr Leu Ser Ala Leu Asp His Cys Tyr Gln Leu Tyr Cys 
    210                 215                 220                 


Ser Lys Ile Gln Lys Gln Leu Gly Glu Lys Phe Asp Ile Glu Arg Leu 
225                 230                 235                 240 


Asp Ala Val Leu Phe His Ala Pro Tyr Cys Lys Leu Val Gln Lys Ser 
                245                 250                 255     


Leu Ala Arg Leu Val Leu Asn Asp Phe Val Arg Ala Ser Glu Glu Glu 
            260                 265                 270         


Arg Thr Thr Lys Tyr Ser Ser Leu Glu Ala Leu Lys Gly Val Lys Leu 
        275                 280                 285             


Glu Asp Thr Tyr Phe Asp Arg Glu Val Glu Lys Ala Val Met Thr Tyr 
    290                 295                 300                 


Ser Lys Asn Met Phe Glu Glu Lys Thr Lys Pro Ser Leu Leu Leu Ala 
305                 310                 315                 320 


Asn Gln Val Gly Asn Met Tyr Thr Pro Ser Leu Tyr Gly Gly Leu Val 
                325                 330                 335     


Ser Leu Leu Val Ser Lys Ser Ala Gln Glu Leu Ala Gly Lys Arg Val 
            340                 345                 350         


Ala Leu Phe Ser Tyr Gly Ser Gly Leu Ala Ser Ser Met Phe Ser Leu 
        355                 360                 365             


Arg Ile Ser Ser Asp Ala Ser Ala Lys Ser Ser Leu Gln Arg Leu Val 
    370                 375                 380                 


Ser Asn Leu Ser His Ile Lys Pro Gln Leu Asp Leu Arg His Lys Val 
385                 390                 395                 400 


Ser Pro Glu Glu Phe Ala Gln Thr Met Glu Thr Arg Glu His Asn His 
                405                 410                 415     


His Lys Ala Pro Tyr Thr Pro Glu Gly Ser Ile Asp Val Leu Phe Pro 
            420                 425                 430         


Gly Thr Trp Tyr Leu Glu Ser Val Asp Ser Leu Tyr Arg Arg Ser Tyr 
        435                 440                 445             


Lys Gln Val Pro Gly 
    450             


<210>  68
<211>  455
<212>  PRT
<213>  Blattella germanica

<400>  68

Met Ala His Trp Pro Glu Asp Val Gly Ile Ile Gly Ile Glu Met Ile 
1               5                   10                  15      


Phe Pro Ser Leu Tyr Val Asp Gln Ala Glu Leu Glu Thr Tyr Asp Glu 
            20                  25                  30          


Val Ser Pro Gly Lys Tyr Thr Met Gly Leu Gly Gln Asp Lys Met Gly 
        35                  40                  45              


Val Cys Thr Asp Arg Glu Asp Ile Asn Ser Leu Cys Leu Thr Ala Val 
    50                  55                  60                  


Asp Lys Leu Met Glu Arg Asn Asn Ile Asp Tyr Asn Asp Ile Gly Trp 
65                  70                  75                  80  


Leu Glu Val Gly Thr Glu Thr Ile Leu Asp Lys Val Lys Ser Val Lys 
                85                  90                  95      


Thr Val Leu Met Gln Leu Phe Glu Glu Ser Gly Asn Thr Asp Val Glu 
            100                 105                 110         


Gly Ile Asp Thr Ile Asn Ala Cys Tyr Arg Gly Thr Ala Ala Leu Phe 
        115                 120                 125             


Asn Ala Leu Ile Trp Ile Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala 
    130                 135                 140                 


Ile Val Val Ala Ala Asp Ile Ala Ile Tyr Ala Lys Glu Cys Ser Pro 
145                 150                 155                 160 


Thr Gly Gly Ala Gly Ala Leu Leu Met Leu Ile Gly Ala Asn Ala Pro 
                165                 170                 175     


Ile Val Ile Asp Arg Gly Val Arg Ala Ser His Met Lys His Ala Tyr 
            180                 185                 190         


Asp Phe Tyr Lys Pro Asp Leu Met Ser Glu Tyr Pro Val Val Asp Gly 
        195                 200                 205             


Lys Leu Ser Val Gln Cys Tyr Leu Ser Ala Leu Asp His Cys Tyr Pro 
    210                 215                 220                 


Arg Phe Cys Ser Lys Thr Glu Lys Tyr Leu Lys Arg Cys Gly Lys Glu 
225                 230                 235                 240 


Asn Thr Lys Ile Asp Leu Asp Tyr Phe Asp Ala Phe Val Phe His Ser 
                245                 250                 255     


Pro Tyr Cys Lys Leu Val Gln Lys Ser Val Ala Arg Leu Val Leu Asn 
            260                 265                 270         


Asp Phe Ile Gln Tyr Pro Glu Lys Tyr Gln Asp Leu Gln Gln Leu Arg 
        275                 280                 285             


Asn Leu Lys Phe Glu Asp Thr Tyr Phe Asp Arg Asp Ile Glu Lys Ile 
    290                 295                 300                 


Phe Met Asp Lys Ser Lys Gln Leu Phe Glu Lys Lys Thr Lys Pro Ser 
305                 310                 315                 320 


Leu Met Leu Ala Asn Gln Val Gly Asn Met Tyr Thr Thr Ser Leu Tyr 
                325                 330                 335     


Gly Gly Leu Val Ser Leu Leu Ile Ser Glu Asp Ile Gly Glu Leu Ala 
            340                 345                 350         


Gly Lys Cys Ile Cys Met Phe Ser Tyr Gly Ser Gly Phe Ala Ala Ser 
        355                 360                 365             


Met Phe Ser Leu His Ile Ser Thr Asp Ser Ser Pro Gly Ser Thr Leu 
    370                 375                 380                 


Ser Arg Leu Val Thr Asn Leu Thr His Ile Lys Pro Gln Val Gln Gln 
385                 390                 395                 400 


Arg Val Lys Leu Ser Pro Gly Glu Phe Glu Asn Ile Met Glu Ile Arg 
                405                 410                 415     


Glu Gln Asn His His Lys Ala Pro Tyr Thr Pro Val Ala Ser Pro Asn 
            420                 425                 430         


Thr Leu Phe Pro Gly Thr Trp Tyr Leu Glu Ser Ile Asp Ser Met His 
        435                 440                 445             


Arg Arg Lys Tyr Lys Arg Val 
    450                 455 


<210>  69
<211>  407
<212>  PRT
<213>  Borrelia burgdorferi

<400>  69

Met Arg Ile Gly Ile Ser Asp Ile Arg Ile Phe Leu Pro Leu Asn Tyr 
1               5                   10                  15      


Leu Asp Phe Ser Val Leu Leu Glu Asn Pro Leu Tyr Phe Ser Asn Glu 
            20                  25                  30          


Val Phe Phe Lys Lys Ile Asn Arg Ala Ile Asp Ala Thr Leu Gln Lys 
        35                  40                  45              


Gly Phe Arg Phe Thr Ser Pro Asn Glu Asp Ser Val Thr Met Ala Ser 
    50                  55                  60                  


Ser Ala Val Lys Leu Ile Phe Asp Asn Asn Asn Leu Asp Leu Ser Lys 
65                  70                  75                  80  


Ile Arg Ile Leu Leu Gly Gly Thr Glu Thr Gly Val Asp His Ser Lys 
                85                  90                  95      


Ala Ile Ser Ser Tyr Val Phe Gly Ala Leu Lys Gln Ser Gly Ile Cys 
            100                 105                 110         


Leu Gly Asn Asn Phe Leu Thr Phe Gln Val Gln His Ala Cys Ala Gly 
        115                 120                 125             


Ala Ala Met Ser Leu His Thr Val Ala Ser Val Leu Ser His Ser Asn 
    130                 135                 140                 


Asn Ser Glu Tyr Gly Ile Val Phe Ser Ser Asp Ile Ala His Tyr Ser 
145                 150                 155                 160 


Asn Leu Thr Thr Ala Glu Ile Thr Gln Gly Ala Gly Ala Thr Ala Ile 
                165                 170                 175     


Leu Ile Glu Lys Asn Pro Lys Leu Leu Ser Ile Asn Leu Ser Glu Phe 
            180                 185                 190         


Gly Val Tyr Thr Asp Asp Val Asp Asp Phe Phe Arg Pro Phe Gly Ser 
        195                 200                 205             


Val Glu Ala Lys Val Arg Gly Gln Tyr Ser Val Glu Cys Tyr Asn Asn 
    210                 215                 220                 


Ala Asn Glu Asn Ala Leu Arg Asp Phe Ala Phe Lys Lys Gln Leu Ser 
225                 230                 235                 240 


Met Lys Asp Leu Phe Ser Asn Tyr Arg Phe Val Leu His Val Pro Phe 
                245                 250                 255     


Ala Lys Met Pro Ile Asp Ser Met His Tyr Ile Leu Lys Lys Tyr Tyr 
            260                 265                 270         


Ser Asp Asp Glu Ser Val Arg Asn Ala Tyr Leu Glu Ser Ile Asp Phe 
        275                 280                 285             


Tyr Asp Gly Val Glu Ala Ala Met Glu Val Gly Asn Leu Tyr Thr Gly 
    290                 295                 300                 


Ser Ile Phe Leu Ser Leu Ala Phe Tyr Leu Lys Arg Val Phe Ser Lys 
305                 310                 315                 320 


Lys Asp Ile Thr Gly Glu Lys Ile Leu Phe Cys Ser Tyr Gly Ser Gly 
                325                 330                 335     


Asn Ile Met Ile Ile Tyr Glu Leu Thr Ile Glu Lys Ser Ala Phe Asp 
            340                 345                 350         


Val Ile Lys Leu Trp Asp Leu Glu Gly Leu Ile Lys Asn Arg Asn Asn 
        355                 360                 365             


Ala Asn Phe Glu Glu Tyr Lys Asp Phe Phe Gln Asn Lys Ile Ile Pro 
    370                 375                 380                 


Gly Glu Ser Arg Gly Phe Tyr Leu Lys Glu Leu Arg Asn Asp Gly Tyr 
385                 390                 395                 400 


Arg Val Tyr Gly Tyr Arg Ala 
                405         


<210>  70
<211>  462
<212>  PRT
<213>  Caenorhabditis elegans

<400>  70

Met Ser Leu Gly Gln Leu Ser Tyr Thr Pro Val Thr Asp Val Gly Ile 
1               5                   10                  15      


Gly Ala Ile Glu Leu Tyr Phe Pro Gln Asn Phe Val Asp Gln Asn Asp 
            20                  25                  30          


Leu Glu Lys Phe Asn Asn Val Ser Ser Gly Lys Tyr Thr Ile Gly Leu 
        35                  40                  45              


Gly Gln Gln Gln Met Gly Phe Cys Ser Asp Asn Glu Asp Ile Val Ser 
    50                  55                  60                  


Ile Ser Leu Thr Val Thr Arg Lys Leu Ile Glu Thr Tyr Lys Ile Ser 
65                  70                  75                  80  


Thr Asp Ser Ile Gly Cys Leu Val Val Gly Thr Glu Thr Met Ile Asp 
                85                  90                  95      


Lys Ser Lys Ser Val Lys Thr Ala Leu Met Asp Leu Phe Pro Gly Asn 
            100                 105                 110         


Ser Asp Ile Glu Gly Val Asp Ile Lys Asn Ala Cys Phe Gly Gly Ala 
        115                 120                 125             


Gln Ala Leu Leu His Ala Ile Asp Trp Val Thr Val Asn His Pro Leu 
    130                 135                 140                 


Asp Lys Lys Asn Ala Ile Val Val Val Ala Asp Ile Ala Ile Tyr Glu 
145                 150                 155                 160 


Glu Gly Pro Ala Arg Cys Thr Gly Gly Ala Gly Ala Ile Ala Phe Leu 
                165                 170                 175     


Ile Cys Pro Asp Ala Ser Ile Pro Ile Asp Arg Gln Phe Ser Ala Cys 
            180                 185                 190         


His Met Lys Asn Thr Trp Asp Phe Phe Lys Pro Ile Thr Pro Ile Pro 
        195                 200                 205             


Ser Glu Tyr Pro Val Val Asp Gly Ser Leu Ser Leu Ser Ser Tyr Leu 
    210                 215                 220                 


Glu Ala Val Arg Met Thr Tyr Thr Tyr Phe Ile Ser Lys Val Asn Arg 
225                 230                 235                 240 


His Thr Thr Gly Ile Asp Gly Leu Asn Ser Phe Asp Gly Val Phe Leu 
                245                 250                 255     


His Ser Pro Phe Thr Lys Met Val Gln Lys Gly Leu Ala Val Met Asn 
            260                 265                 270         


Tyr Thr Asp Ser Gln Leu Arg His Lys Gln Leu Asn Gly Asn Gly Val 
        275                 280                 285             


Asp His Lys Leu Asp Glu Asn Asp Arg Ala Gly Leu Ala Lys Met Ile 
    290                 295                 300                 


Glu Leu Ser Ala Gln Val Trp Lys Glu Lys Thr Asp Pro Tyr Leu Val 
305                 310                 315                 320 


Phe Asn Arg Arg Ile Gly Asn Met Tyr Thr Pro Ser Leu Phe Ala Gln 
                325                 330                 335     


Leu Leu Ala Tyr Leu Ala Ala Asp Asp Cys Val Thr Gly Glu Lys Ser 
            340                 345                 350         


Ile Leu Phe Phe Ala Tyr Gly Ser Gly Leu Ala Ser Ala Ile Phe Pro 
        355                 360                 365             


Gly Arg Val Arg Gln Thr Ser Asn Leu Asp Lys Ile Arg Gln Val Ala 
    370                 375                 380                 


Ile Arg Ala Ile Lys Arg Leu Asp Asp Arg Ile Gln Phe Thr Pro Glu 
385                 390                 395                 400 


Glu Phe Thr Glu Thr Leu Gln Lys Arg Glu Val Phe Leu Arg Ser Lys 
                405                 410                 415     


Glu Ile Pro Lys Ser Pro Ser Glu Thr Ser Leu Phe Pro Asn Thr Tyr 
            420                 425                 430         


Phe Leu Asp Asn Met Asp Lys Leu Tyr Arg Arg Ser Tyr Thr Leu His 
        435                 440                 445             


Glu Glu Pro Asn Gly Val Gln Asn Gly Asn Gly Ile His His 
    450                 455                 460         


<210>  71
<211>  520
<212>  PRT
<213>  Cricetulus griseus

<400>  71

Met Pro Gly Ser Leu Pro Leu Asn Ala Glu Ala Cys Trp Pro Lys Asp 
1               5                   10                  15      


Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp 
            20                  25                  30          


Gln Ala Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr 
        35                  40                  45              


Ile Gly Leu Gly Gln Ala Arg Met Gly Phe Cys Thr Asp Arg Glu Asp 
    50                  55                  60                  


Ile Asn Ser Leu Cys Leu Thr Val Val Gln Asn Leu Met Glu Arg Asn 
65                  70                  75                  80  


Ser Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
                85                  90                  95      


Ile Ile Asp Lys Ser Lys Ser Val Lys Ser Asn Leu Met Gln Leu Phe 
            100                 105                 110         


Glu Glu Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala 
        115                 120                 125             


Cys Tyr Gly Gly Thr Ala Ala Val Phe Asn Ala Val Asn Trp Ile Glu 
    130                 135                 140                 


Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Ile Tyr Ala Thr Gly Asn Ala Arg Pro Thr Gly Gly Val Gly Ala 
                165                 170                 175     


Val Ala Leu Leu Ile Gly Pro Asn Ala Pro Leu Ile Phe Asp Arg Gly 
            180                 185                 190         


Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp 
        195                 200                 205             


Met Leu Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu Ser Ile Gln Cys 
    210                 215                 220                 


Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Arg Lys Lys Ile 
225                 230                 235                 240 


Arg Ala Gln Trp Gln Lys Glu Gly Asn Asp Asn Asp Phe Thr Leu Asn 
                245                 250                 255     


Asp Phe Gly Phe Met Ile Ser His Ser Pro Tyr Cys Lys Leu Val Gln 
            260                 265                 270         


Lys Ser Leu Ala Arg Met Phe Leu Asn Asp Phe Leu Asn Asp Gln Asn 
        275                 280                 285             


Arg Asp Lys Asn Ser Ile Tyr Ser Gly Leu Glu Ala Phe Gly Asp Val 
    290                 295                 300                 


Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe Met 
305                 310                 315                 320 


Lys Ala Ser Ser Glu Leu Phe Asn Gln Lys Thr Lys Ala Ser Leu Leu 
                325                 330                 335     


Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Ser Ser Val Tyr Gly Ser 
            340                 345                 350         


Leu Ala Ser Val Leu Ala Gln Tyr Ser Pro Gln Gln Leu Ala Gly Lys 
        355                 360                 365             


Arg Ile Gly Val Phe Ser Tyr Gly Ser Gly Leu Ala Ala Thr Leu Tyr 
    370                 375                 380                 


Ser Leu Lys Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp Lys 
385                 390                 395                 400 


Val Thr Ala Ser Leu Cys Asp Leu Lys Ser Arg Leu Asp Ser Arg Thr 
                405                 410                 415     


Cys Val Ala Pro Asp Val Phe Ala Glu Asn Met Lys Leu Arg Glu Asp 
            420                 425                 430         


Thr His His Leu Ala Asn Tyr Ile Pro Gln Cys Ser Ile Asp Ser Leu 
        435                 440                 445             


Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg Arg 
    450                 455                 460                 


Thr Tyr Ala Arg Arg Pro Ser Thr Asn Asp His Asn Leu Gly Asp Gly 
465                 470                 475                 480 


Val Gly Leu Val His Ser Asn Thr Ala Thr Glu His Ile Pro Ser Pro 
                485                 490                 495     


Ala Lys Lys Val Pro Arg Leu Pro Ala Thr Ala Ala Glu Ser Glu Ser 
            500                 505                 510         


Ala Val Ile Ser Asn Gly Glu His 
        515                 520 


<210>  72
<211>  522
<212>  PRT
<213>  Gallus gallus

<400>  72

Met Pro Gly Ser Leu Pro Val Asn Thr Glu Ser Cys Trp Pro Lys Asp 
1               5                   10                  15      


Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp 
            20                  25                  30          


Gln Thr Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr 
        35                  40                  45              


Ile Gly Leu Gly Gln Ser Lys Met Gly Phe Cys Ser Asp Arg Glu Asp 
    50                  55                  60                  


Ile Asn Ser Leu Cys Leu Thr Val Val Gln Lys Leu Met Glu Arg Asn 
65                  70                  75                  80  


Ser Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
                85                  90                  95      


Ile Ile Asp Lys Ser Lys Ser Val Lys Thr Val Leu Met Gln Leu Phe 
            100                 105                 110         


Glu Glu Ser Gly Asn Thr Asp Val Glu Gly Ile Asp Thr Thr Asn Ala 
        115                 120                 125             


Cys Tyr Gly Gly Thr Ala Ala Leu Phe Asn Ala Ile Asn Trp Ile Glu 
    130                 135                 140                 


Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Val Tyr Ala Thr Gly Asn Ala Arg Pro Thr Gly Gly Ala Gly Ala 
                165                 170                 175     


Val Ala Met Leu Val Gly Ser Asn Ala Pro Leu Ile Phe Glu Arg Gly 
            180                 185                 190         


Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp 
        195                 200                 205             


Met Val Ser Glu Tyr Pro Val Val Asp Gly Lys Leu Ser Ile Gln Cys 
    210                 215                 220                 


Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Arg Asn Lys Ile 
225                 230                 235                 240 


His Ala Gln Trp Gln Lys Glu Gly Thr Asp Arg Gly Phe Thr Leu Asn 
                245                 250                 255     


Asp Phe Gly Phe Met Ile Phe His Ser Pro Tyr Cys Lys Leu Val Gln 
            260                 265                 270         


Lys Ser Val Ala Arg Leu Leu Leu Asn Asp Phe Leu Ser Asp Gln Asn 
        275                 280                 285             


Ala Glu Thr Ala Asn Gly Val Phe Ser Gly Leu Glu Ala Phe Arg Asp 
    290                 295                 300                 


Val Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe 
305                 310                 315                 320 


Met Lys Ala Ser Ala Glu Leu Phe Asn Gln Lys Thr Lys Ala Ser Leu 
                325                 330                 335     


Leu Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Pro Ser Val Tyr Gly 
            340                 345                 350         


Cys Leu Ala Ser Leu Leu Ala Gln Tyr Ser Pro Glu His Leu Ala Gly 
        355                 360                 365             


Gln Arg Ile Ser Glu Phe Ser Tyr Gly Ser Gly Phe Ala Ala Thr Leu 
    370                 375                 380                 


Tyr Ser Ile Arg Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp 
385                 390                 395                 400 


Lys Ile Thr Ala Ser Leu Ser Asp Leu Lys Ala Arg Leu Asp Ser Arg 
                405                 410                 415     


Lys Cys Ile Ala Pro Asp Val Phe Ala Glu Asn Met Lys Ile Arg Gln 
            420                 425                 430         


Glu Thr His His Leu Ala Asn Tyr Ile Pro Gln Cys Ser Val Glu Asp 
        435                 440                 445             


Leu Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg 
    450                 455                 460                 


Arg Thr Tyr Ala Arg Arg Pro Val Met Gly Asp Gly Pro Leu Glu Ala 
465                 470                 475                 480 


Gly Val Glu Val Val His Pro Gly Ile Val His Glu His Ile Pro Ser 
                485                 490                 495     


Pro Ala Lys Lys Val Pro Arg Ile Pro Ala Thr Thr Glu Ser Glu Gly 
            500                 505                 510         


Val Thr Val Ala Ile Ser Asn Gly Val His 
        515                 520         


<210>  73
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Pro Gly Ser Leu Pro Leu Asn Ala Glu Ala Cys Trp Pro Lys Asp 
1               5                   10                  15      


Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp 
            20                  25                  30          


Gln Ala Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr 
        35                  40                  45              


Ile Gly Leu Gly Gln Ala Lys Met Gly Phe Cys Thr Asp Arg Glu Asp 
    50                  55                  60                  


Ile Asn Ser Leu Cys Met Thr Val Val Gln Asn Leu Met Glu Arg Asn 
65                  70                  75                  80  


Asn Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
                85                  90                  95      


Ile Ile Asp Lys Ser Lys Ser Val Lys Thr Asn Leu Met Gln Leu Phe 
            100                 105                 110         


Glu Glu Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala 
        115                 120                 125             


Cys Tyr Gly Gly Thr Ala Ala Val Phe Asn Ala Val Asn Trp Ile Glu 
    130                 135                 140                 


Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Val Tyr Ala Thr Gly Asn Ala Arg Pro Thr Gly Gly Val Gly Ala 
                165                 170                 175     


Val Ala Leu Leu Ile Gly Pro Asn Ala Pro Leu Ile Phe Glu Arg Gly 
            180                 185                 190         


Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp 
        195                 200                 205             


Met Leu Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu Ser Ile Gln Cys 
    210                 215                 220                 


Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Cys Lys Lys Ile 
225                 230                 235                 240 


His Ala Gln Trp Gln Lys Glu Gly Asn Asp Lys Asp Phe Thr Leu Asn 
                245                 250                 255     


Asp Phe Gly Phe Met Ile Phe His Ser Pro Tyr Cys Lys Leu Val Gln 
            260                 265                 270         


Lys Ser Leu Ala Arg Met Leu Leu Asn Asp Phe Leu Asn Asp Gln Asn 
        275                 280                 285             


Arg Asp Lys Asn Ser Ile Tyr Ser Gly Leu Glu Ala Phe Gly Asp Val 
    290                 295                 300                 


Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe Met 
305                 310                 315                 320 


Lys Ala Ser Ser Glu Leu Phe Ser Gln Lys Thr Lys Ala Ser Leu Leu 
                325                 330                 335     


Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Ser Ser Val Tyr Gly Ser 
            340                 345                 350         


Leu Ala Ser Val Leu Ala Gln Tyr Ser Pro Gln Gln Leu Ala Gly Lys 
        355                 360                 365             


Arg Ile Gly Val Phe Ser Tyr Gly Ser Gly Leu Ala Ala Thr Leu Tyr 
    370                 375                 380                 


Ser Leu Lys Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp Lys 
385                 390                 395                 400 


Ile Thr Ala Ser Leu Cys Asp Leu Lys Ser Arg Leu Asp Ser Arg Thr 
                405                 410                 415     


Gly Val Ala Pro Asp Val Phe Ala Glu Asn Met Lys Leu Arg Glu Asp 
            420                 425                 430         


Thr His His Leu Val Asn Tyr Ile Pro Gln Gly Ser Ile Asp Ser Leu 
        435                 440                 445             


Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg Arg 
    450                 455                 460                 


Thr Tyr Ala Arg Arg Pro Thr Pro Asn Asp Asp Thr Leu Asp Glu Gly 
465                 470                 475                 480 


Val Gly Leu Val His Ser Asn Ile Ala Thr Glu His Ile Pro Ser Pro 
                485                 490                 495     


Ala Lys Lys Val Pro Arg Leu Pro Ala Thr Ala Ala Glu Pro Glu Ala 
            500                 505                 510         


Ala Val Ile Ser Asn Gly Glu His 
        515                 520 


<210>  74
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg 
1               5                   10                  15      


Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala 
            20                  25                  30          


His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp 
        35                  40                  45              


Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
    50                  55                  60                  


Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu 
65                  70                  75                  80  


Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                85                  90                  95      


Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
            100                 105                 110         


Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu 
        115                 120                 125             


Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
    130                 135                 140                 


Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
145                 150                 155                 160 


Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                165                 170                 175     


Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala Met Val 
            180                 185                 190         


Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr 
        195                 200                 205             


Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
    210                 215                 220                 


Ala Leu Glu Arg Gly Leu Arg Gly Thr His Met Glu Asn Val Tyr Asp 
225                 230                 235                 240 


Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys 
                245                 250                 255     


Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser 
            260                 265                 270         


Tyr Arg Lys Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg 
        275                 280                 285             


Pro Phe Thr Leu Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe 
    290                 295                 300                 


Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
305                 310                 315                 320 


Leu Ser Ala Ser Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu 
                325                 330                 335     


Ala Phe Gly Gly Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu 
            340                 345                 350         


Asp Lys Ala Leu Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr 
        355                 360                 365             


Lys Ala Ser Leu Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser 
    370                 375                 380                 


Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
385                 390                 395                 400 


Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                405                 410                 415     


Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly 
            420                 425                 430         


Ser Pro Leu Asp Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg 
        435                 440                 445             


Leu Ala Ser Arg Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met 
    450                 455                 460                 


Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
465                 470                 475                 480 


Asp Thr Asn Ser Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                485                 490                 495     


Glu Gln His Arg Arg Lys Tyr Ala Arg Arg Pro Val 
            500                 505             


<210>  75
<211>  460
<212>  PRT
<213>  Ips pini

<400>  75

Met Gly Ser Trp Pro Glu Asp Val Gly Ile Leu Ala Leu Glu Ile Ile 
1               5                   10                  15      


Phe Pro Ser Gln Tyr Val Asp Gln Thr Glu Leu Glu Gln Phe Asp Gly 
            20                  25                  30          


Val Ser Ser Gly Lys Tyr Thr Ile Gly Leu Gly Gln Gln Arg Met Gly 
        35                  40                  45              


Phe Cys Asn Asp Arg Glu Asp Ile His Ser Leu Cys Leu Thr Val Val 
    50                  55                  60                  


Asp Asn Leu Leu Lys Arg Tyr Asn Ile Lys Pro Gln Glu Ile Gly Arg 
65                  70                  75                  80  


Leu Glu Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ser Val Lys 
                85                  90                  95      


Thr Val Leu Met Gln Leu Phe Glu Pro His Gly Val Thr Asp Ile Glu 
            100                 105                 110         


Gly Ile Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ala Leu Met 
        115                 120                 125             


Asn Ala Ile Ser Trp Val Glu Ser Ser Ser Trp Asn Gly Arg Tyr Ala 
    130                 135                 140                 


Leu Val Val Ala Gly Asp Ile Ala Val Tyr Ala Lys Gly Ala Ala Arg 
145                 150                 155                 160 


Pro Thr Gly Gly Ser Gly Ala Val Ala Met Leu Val Gly Pro Asn Ala 
                165                 170                 175     


Pro Leu Val Phe Asp Arg Gly Val Lys Gly Tyr Phe Phe Lys His Ala 
            180                 185                 190         


Tyr Asp Phe Tyr Lys Pro Asp Leu Thr Ser Glu Tyr Pro Ile Val Asp 
        195                 200                 205             


Gly Lys Leu Ser Val Gln Cys Tyr Leu Glu Ala Leu Asp Lys Cys Tyr 
    210                 215                 220                 


Gln Leu Tyr Cys Gln Asn Ala Glu Lys Lys Trp Gln Lys Pro Val Asp 
225                 230                 235                 240 


Ile Gly Lys Phe Asp Gly Leu Leu Phe His Thr Pro Tyr Cys Lys Leu 
                245                 250                 255     


Val Gln Lys Ser Val Gly Arg Leu Ala Leu Asn Asp Tyr Met Arg Leu 
            260                 265                 270         


Pro Lys Asp Lys Arg Ala Ala Leu Pro Glu Leu Gln Lys Phe Val Asp 
        275                 280                 285             


Val Glu Leu Ser Lys Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe 
    290                 295                 300                 


Leu Thr Ser Ser Ser Glu Val Phe Ala Lys Lys Thr Lys Pro Ser Leu 
305                 310                 315                 320 


Leu Val Ala Thr Asn Leu Gly Asn Met Tyr Thr Ala Ser Leu Tyr Gly 
                325                 330                 335     


Gly Leu Val Ser Tyr Leu Val Ser Lys Asp Val Ser Glu Leu Ala Gly 
            340                 345                 350         


Asn Arg Leu Gly Leu Phe Ser Tyr Gly Ser Gly Leu Ala Ser Cys Phe 
        355                 360                 365             


Tyr Ser Val Thr Ile Lys Asp Ser Pro Ala Leu Lys Thr Leu Ile Lys 
    370                 375                 380                 


Asn Leu Ser Tyr Val Lys Pro Leu Leu Glu Lys Arg Val Lys Val Ala 
385                 390                 395                 400 


Pro Glu Lys Phe Glu Ala Thr Leu Glu Leu Arg Gln His Asn Ala His 
                405                 410                 415     


Lys Phe Pro Tyr Glu Pro Ile Ser Asp Val Ser Asn Phe Phe Pro Gly 
            420                 425                 430         


Thr Tyr Tyr Leu Thr Lys Val Asp Glu Gln His Arg Arg Ser Tyr Ser 
        435                 440                 445             


Lys Val Pro Gly Ser Ser Cys Thr Asn Gly His Ala 
    450                 455                 460 


<210>  76
<211>  508
<212>  PRT
<213>  Mus musculus

<400>  76

Met Gln Arg Leu Leu Ala Pro Ala Arg Arg Val Leu Gln Val Lys Arg 
1               5                   10                  15      


Ala Met Gln Glu Thr Ser Leu Thr Pro Ala His Leu Leu Ser Ala Ala 
            20                  25                  30          


Gln Gln Arg Phe Ser Thr Ile Pro Pro Ala Pro Leu Ala Lys Thr Asp 
        35                  40                  45              


Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
    50                  55                  60                  


Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Phe Asn Asn Val Glu 
65                  70                  75                  80  


Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                85                  90                  95      


Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
            100                 105                 110         


Leu Met Glu Arg Thr Lys Leu Pro Trp Asp Ala Val Gly Arg Leu Glu 
        115                 120                 125             


Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
    130                 135                 140                 


Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
145                 150                 155                 160 


Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                165                 170                 175     


Ala Asn Trp Met Glu Ser Ser Tyr Trp Asp Gly Arg Tyr Ala Leu Val 
            180                 185                 190         


Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr 
        195                 200                 205             


Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
    210                 215                 220                 


Val Leu Glu Gln Gly Leu Arg Gly Thr His Met Glu Asn Ala Tyr Asp 
225                 230                 235                 240 


Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Leu Val Asp Gly Lys 
                245                 250                 255     


Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Ala Ala 
            260                 265                 270         


Tyr Arg Lys Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Asn Asn Gln 
        275                 280                 285             


Pro Phe Thr Leu Asp Asp Val Gln Tyr Met Ile Phe His Thr Pro Phe 
    290                 295                 300                 


Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
305                 310                 315                 320 


Leu Ser Ser Ser Ser Asp Lys Gln Asn Asn Leu Tyr Lys Gly Leu Glu 
                325                 330                 335     


Ala Phe Arg Gly Leu Lys Leu Glu Glu Thr Tyr Thr Asn Lys Asp Val 
            340                 345                 350         


Asp Lys Ala Leu Leu Lys Ala Ser Leu Asp Met Phe Asn Gln Lys Thr 
        355                 360                 365             


Lys Ala Ser Leu Tyr Leu Ser Thr Asn Asn Gly Asn Met Tyr Thr Ser 
    370                 375                 380                 


Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
385                 390                 395                 400 


Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                405                 410                 415     


Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Lys Asp Ala Ser Pro Gly 
            420                 425                 430         


Ser Pro Leu Glu Lys Leu Val Ser Ser Val Ser Asp Leu Pro Lys Arg 
        435                 440                 445             


Leu Asp Ser Arg Arg Arg Met Ser Pro Glu Glu Phe Thr Glu Ile Met 
    450                 455                 460                 


Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
465                 470                 475                 480 


Asp Thr Ser Asn Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                485                 490                 495     


Glu Met His Arg Arg Lys Tyr Ala Arg Cys Pro Val 
            500                 505             


<210>  77
<211>  474
<212>  PRT
<213>  Pinus sylvestris

<400>  77

Met Ala Ser Arg Pro Glu Asn Val Gly Ile Leu Ala Met Glu Ile Tyr 
1               5                   10                  15      


Phe Pro Thr Thr Cys Val Gln Gln Glu Asp Leu Glu Thr Phe Asp Gly 
            20                  25                  30          


Val Ser Lys Gly Lys Tyr Thr Ile Gly Leu Gly Gln Asp Cys Met Thr 
        35                  40                  45              


Phe Cys Thr Asp Leu Glu Asp Val Ile Ser Met Ser Leu Thr Ala Val 
    50                  55                  60                  


Thr Ser Leu Leu Glu Lys Tyr Glu Ile Asp Pro Lys Gln Ile Gly Arg 
65                  70                  75                  80  


Leu Glu Val Gly Ser Glu Thr Val Ile Asp Lys Ser Lys Ser Ile Lys 
                85                  90                  95      


Thr Trp Leu Met His Ile Phe Glu Lys Cys Gly Asn Thr Glu Ile Glu 
            100                 105                 110         


Gly Val Asp Ser Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ala Leu Phe 
        115                 120                 125             


Asn Cys Ile Asn Trp Ile Glu Ser Ser Ser Trp Asp Gly Arg Tyr Gly 
    130                 135                 140                 


Leu Val Val Ala Thr Asp Ser Ala Val Tyr Ala Glu Gly Ala Ala Arg 
145                 150                 155                 160 


Pro Thr Gly Gly Ala Ala Ala Val Ala Met Leu Ile Gly Pro Asn Ala 
                165                 170                 175     


Pro Ile Ala Thr Glu Ser Lys Tyr Arg Gly Thr His Met Ala His Val 
            180                 185                 190         


Tyr Asp Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Val Val Asp 
        195                 200                 205             


Gly Lys Leu Ser Gln Thr Cys Tyr Leu Met Ala Leu Asp Ser Cys Tyr 
    210                 215                 220                 


Lys Arg Phe Cys Asn Lys Phe Glu Lys Glu Glu Gly Arg Gln Phe Ser 
225                 230                 235                 240 


Leu Leu Asp Thr Asp Tyr Ile Ala Phe His Ser Pro Tyr Asn Lys Leu 
                245                 250                 255     


Val Gln Lys Ser Phe Gly Arg Leu Leu Phe Asn Asp Phe Ser Arg His 
            260                 265                 270         


Ala Arg Ser Val Gly Lys Asp Ala Gln Glu Lys Leu Glu Pro Phe Ala 
        275                 280                 285             


Gly Leu Ser Glu Gln Asp Ser Tyr Asn Ser Arg Asp Leu Glu Lys Val 
    290                 295                 300                 


Ser Gln Gln Leu Ala Lys Pro Leu Tyr Asp Ala Lys Ile Gln Pro Ser 
305                 310                 315                 320 


Thr Leu Leu Pro Lys Gln Val Gly Asn Met Tyr Thr Ala Ser Leu Tyr 
                325                 330                 335     


Ala Ala Leu Ala Ser Ile Ile His Asn Lys His Thr Thr Leu Asp Gly 
            340                 345                 350         


Gln Arg Val Met Met Phe Ser Tyr Gly Ser Gly Leu Ala Ser Thr Leu 
        355                 360                 365             


Phe Ser Phe Lys Ile Arg Glu Gly Gln Phe Pro Phe Thr Leu Ser Asn 
    370                 375                 380                 


Ile Thr Glu Val Met Asp Val Gln Asn Lys Leu Asp Ser Arg His Glu 
385                 390                 395                 400 


Phe Leu Pro Glu Asp Phe Val Glu Asn Leu Lys Arg Met Glu Thr Leu 
                405                 410                 415     


Tyr Gly Ala Lys Asp Phe Val Ser Thr Ser Gln Leu Ser Leu Leu Arg 
            420                 425                 430         


Pro Gly Ala Phe Tyr Leu Thr Lys Val Asp Ser Met Tyr Arg Arg Phe 
        435                 440                 445             


Tyr Ser Arg Lys Val Ile Ser Ala Gly Asp Asn Phe Glu Lys Ser Lys 
    450                 455                 460                 


Leu Ala Asn Gly Thr Thr His Asp Glu Leu 
465                 470                 


<210>  78
<211>  520
<212>  PRT
<213>  Rattus norvegicus

<400>  78

Met Pro Gly Ser Leu Pro Leu Asn Ala Glu Ala Cys Trp Pro Lys Asp 
1               5                   10                  15      


Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp 
            20                  25                  30          


Gln Ala Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr 
        35                  40                  45              


Ile Gly Leu Gly Gln Ala Arg Met Gly Phe Cys Thr Asp Arg Glu Asp 
    50                  55                  60                  


Ile Asn Ser Leu Cys Leu Thr Val Val Gln Lys Leu Met Glu Arg Asn 
65                  70                  75                  80  


Ser Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
                85                  90                  95      


Ile Ile Asp Lys Ser Lys Ser Val Lys Ser Asn Leu Met Gln Leu Phe 
            100                 105                 110         


Glu Glu Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala 
        115                 120                 125             


Cys Tyr Gly Gly Thr Ala Ala Val Phe Asn Ala Val Asn Trp Ile Glu 
    130                 135                 140                 


Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Ile Tyr Ala Ser Gly Asn Ala Arg Pro Thr Gly Gly Val Gly Ala 
                165                 170                 175     


Val Ala Leu Leu Ile Gly Pro Asn Ala Pro Val Ile Phe Asp Arg Gly 
            180                 185                 190         


Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp 
        195                 200                 205             


Met Leu Ser Glu Tyr Pro Val Val Asp Gly Lys Leu Ser Ile Gln Cys 
    210                 215                 220                 


Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Arg Lys Lys Ile 
225                 230                 235                 240 


Arg Ala Gln Trp Gln Lys Glu Gly Lys Asp Lys Asp Phe Thr Leu Asn 
                245                 250                 255     


Asp Phe Gly Phe Met Ile Phe His Ser Pro Tyr Cys Lys Leu Val Gln 
            260                 265                 270         


Lys Ser Leu Ala Arg Met Phe Leu Asn Asp Phe Leu Asn Asp Gln Asn 
        275                 280                 285             


Arg Asp Lys Asn Ser Ile Tyr Ser Gly Leu Glu Ala Phe Gly Asp Val 
    290                 295                 300                 


Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe Met 
305                 310                 315                 320 


Lys Ala Ser Ala Glu Leu Phe Asn Gln Lys Thr Lys Ala Ser Leu Leu 
                325                 330                 335     


Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Ser Ser Val Tyr Gly Ser 
            340                 345                 350         


Leu Ala Ser Val Leu Ala Gln Tyr Ser Pro Gln Gln Leu Ala Gly Lys 
        355                 360                 365             


Arg Ile Gly Val Phe Ser Tyr Gly Ser Gly Leu Ala Ala Thr Leu Tyr 
    370                 375                 380                 


Ser Leu Lys Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp Lys 
385                 390                 395                 400 


Ile Thr Ala Ser Leu Cys Asp Leu Lys Ser Arg Leu Asp Ser Arg Thr 
                405                 410                 415     


Cys Val Ala Pro Asp Val Phe Ala Glu Asn Met Lys Leu Arg Glu Asp 
            420                 425                 430         


Thr His His Leu Ala Asn Tyr Ile Pro Gln Cys Ser Ile Asp Ser Leu 
        435                 440                 445             


Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg Arg 
    450                 455                 460                 


Thr Tyr Ala Arg Arg Pro Ser Thr Asn Asp His Ser Leu Asp Glu Gly 
465                 470                 475                 480 


Val Gly Leu Val His Ser Asn Thr Ala Thr Glu His Ile Pro Ser Pro 
                485                 490                 495     


Ala Lys Lys Val Pro Arg Leu Pro Ala Thr Ser Gly Glu Pro Glu Ser 
            500                 505                 510         


Ala Val Ile Ser Asn Gly Glu His 
        515                 520 


<210>  79
<211>  508
<212>  PRT
<213>  Rattus norvegicus

<400>  79

Met Gln Arg Leu Leu Ala Pro Ala Arg Arg Val Leu Gln Val Lys Arg 
1               5                   10                  15      


Val Met Gln Glu Ser Ser Leu Ser Pro Ala His Leu Leu Pro Ala Ala 
            20                  25                  30          


Gln Gln Arg Phe Ser Thr Ile Pro Pro Ala Pro Leu Ala Lys Thr Asp 
        35                  40                  45              


Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
    50                  55                  60                  


Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Phe Asn Asn Val Glu 
65                  70                  75                  80  


Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                85                  90                  95      


Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
            100                 105                 110         


Leu Met Glu Arg Thr Lys Leu Pro Trp Asp Ala Val Gly Arg Leu Glu 
        115                 120                 125             


Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
    130                 135                 140                 


Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
145                 150                 155                 160 


Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                165                 170                 175     


Ala Asn Trp Met Glu Ser Ser Tyr Trp Asp Gly Arg Tyr Ala Leu Val 
            180                 185                 190         


Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Pro Arg Pro Thr 
        195                 200                 205             


Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
    210                 215                 220                 


Val Leu Glu Gln Gly Leu Arg Gly Thr His Met Glu Asn Ala Tyr Asp 
225                 230                 235                 240 


Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Leu Val Asp Gly Lys 
                245                 250                 255     


Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Ala Ala 
            260                 265                 270         


Tyr Arg Arg Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Asn Asn Gln 
        275                 280                 285             


Pro Phe Thr Leu Asp Asp Val Gln Tyr Met Ile Phe His Thr Pro Phe 
    290                 295                 300                 


Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
305                 310                 315                 320 


Leu Ser Ser Ser Ser Asp Lys Gln Asn Asn Leu Tyr Lys Gly Leu Glu 
                325                 330                 335     


Ala Phe Lys Gly Leu Lys Leu Glu Glu Thr Tyr Thr Asn Lys Asp Val 
            340                 345                 350         


Asp Lys Ala Leu Leu Lys Ala Ser Leu Asp Met Phe Asn Lys Lys Thr 
        355                 360                 365             


Lys Ala Ser Leu Tyr Leu Ser Thr Asn Asn Gly Asn Met Tyr Thr Ser 
    370                 375                 380                 


Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
385                 390                 395                 400 


Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                405                 410                 415     


Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Lys Asp Ala Ser Pro Gly 
            420                 425                 430         


Ser Pro Leu Glu Lys Leu Val Ser Ser Val Ser Asp Leu Pro Lys Arg 
        435                 440                 445             


Leu Asp Ser Arg Arg Arg Met Ser Pro Glu Glu Phe Thr Glu Ile Met 
    450                 455                 460                 


Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
465                 470                 475                 480 


Asp Thr Ser Asn Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                485                 490                 495     


Glu Met His Arg Arg Lys Tyr Ala Arg Arg Pro Val 
            500                 505             


<210>  80
<211>  508
<212>  PRT
<213>  Sus scrofa

<400>  80

Met Gln Arg Leu Leu Thr Pro Val Arg Gln Val Leu Arg Val Lys Arg 
1               5                   10                  15      


Ala Met Gln Glu Ala Ser Phe Met Pro Pro Leu Leu Pro Pro Ala Ala 
            20                  25                  30          


His Gln Arg Phe Ser Thr Val Pro Ala Val Pro Val Ala Lys Ala Asp 
        35                  40                  45              


Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
    50                  55                  60                  


Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Phe Asp Asn Val Glu 
65                  70                  75                  80  


Ala Gly Arg Tyr Thr Val Gly Leu Gly Gln Thr His Met Gly Phe Cys 
                85                  90                  95      


Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
            100                 105                 110         


Leu Met Glu Arg Thr Gln Leu Pro Trp Asp Ser Val Gly Trp Leu Glu 
        115                 120                 125             


Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ser Val Lys Thr Val 
    130                 135                 140                 


Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
145                 150                 155                 160 


Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                165                 170                 175     


Ala Asn Trp Val Glu Ser Ser Ala Trp Asp Gly Arg Tyr Ala Val Val 
            180                 185                 190         


Val Cys Gly Asp Ile Ala Val Tyr Pro Arg Gly Asn Ser Arg Pro Thr 
        195                 200                 205             


Gly Gly Ala Gly Ala Val Ala Met Leu Val Gly Pro Glu Ala Pro Leu 
    210                 215                 220                 


Ala Leu Glu Arg Gly Leu Arg Gly Thr His Met Glu Asn Ala Tyr Asp 
225                 230                 235                 240 


Phe Tyr Lys Pro Asn Ala Thr Ser Glu Tyr Pro Leu Val Asp Gly Lys 
                245                 250                 255     


Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Leu 
            260                 265                 270         


Tyr Arg Gln Lys Ile Glu Lys Gln Trp Lys Gln Ala Gly Ile Glu Arg 
        275                 280                 285             


His Phe Thr Leu Asp Asp Leu Gln Phe Met Ile Phe His Thr Pro Phe 
    290                 295                 300                 


Cys Lys Leu Val Gln Lys Ser Leu Ala Arg Leu Met Phe Ser Asp Phe 
305                 310                 315                 320 


Leu Leu Ala Asp Ser Asp Thr Gln Ser Ser Leu Tyr Lys Gly Leu Glu 
                325                 330                 335     


Ala Phe Arg Gly Gln Lys Leu Glu Asp Thr Tyr Ala Asn Lys Asp Ile 
            340                 345                 350         


Glu Lys Ala Phe Gln Lys Ala Ser Leu Asp Leu Phe Asn Lys Lys Thr 
        355                 360                 365             


Lys Pro Ser Leu Tyr Leu Ser Leu His Asn Gly Asn Met Tyr Thr Ser 
    370                 375                 380                 


Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser Gln Cys Ser Ala Gln 
385                 390                 395                 400 


Asp Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                405                 410                 415     


Ala Ala Ser Phe Tyr Ser Leu Arg Val Ser Gln Asp Ala Ser Pro Gly 
            420                 425                 430         


Ser Pro Leu Glu Lys Leu Val Ser Ser Val Ser Asp Leu Pro Glu Arg 
        435                 440                 445             


Leu Ala Ser Arg Lys Arg Val Ser Pro Glu Glu Phe Thr Glu Ile Met 
    450                 455                 460                 


Asn Gln Arg Glu Gln Tyr Tyr His Lys Val Asn Phe Thr Pro Pro Gly 
465                 470                 475                 480 


Asp Pro Asn Ser Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                485                 490                 495     


Glu Leu Tyr Arg Arg Lys Tyr Ala Arg His Leu Val 
            500                 505             


<210>  81
<211>  299
<212>  PRT
<213>  Bacillus subtilis

<400>  81

Met Pro Tyr Pro Lys Lys Val Thr Ile Lys Glu Val Gly Pro Arg Asp 
1               5                   10                  15      


Gly Leu Gln Asn Glu Pro Val Trp Ile Ala Thr Glu Asp Lys Ile Thr 
            20                  25                  30          


Trp Ile Asn Gln Leu Ser Arg Thr Gly Leu Ser Tyr Ile Glu Ile Thr 
        35                  40                  45              


Ser Phe Val His Pro Lys Trp Ile Pro Ala Leu Arg Asp Ala Ile Asp 
    50                  55                  60                  


Val Ala Lys Gly Ile Asp Arg Glu Lys Gly Val Thr Tyr Ala Ala Leu 
65                  70                  75                  80  


Val Pro Asn Gln Arg Gly Leu Glu Asn Ala Leu Glu Gly Gly Ile Asn 
                85                  90                  95      


Glu Ala Cys Val Phe Met Ser Ala Ser Glu Thr His Asn Arg Lys Asn 
            100                 105                 110         


Ile Asn Lys Ser Thr Ser Glu Ser Leu His Ile Leu Lys Gln Val Asn 
        115                 120                 125             


Asn Asp Ala Gln Lys Ala Asn Leu Thr Thr Arg Ala Tyr Leu Ser Thr 
    130                 135                 140                 


Val Phe Gly Cys Pro Tyr Glu Lys Asp Val Pro Ile Glu Gln Val Ile 
145                 150                 155                 160 


Arg Leu Ser Glu Ala Leu Phe Glu Phe Gly Ile Ser Glu Leu Ser Leu 
                165                 170                 175     


Gly Asp Thr Ile Gly Ala Ala Asn Pro Ala Gln Val Glu Thr Val Leu 
            180                 185                 190         


Glu Ala Leu Leu Ala Arg Phe Pro Ala Asn Gln Ile Ala Leu His Phe 
        195                 200                 205             


His Asp Thr Arg Gly Thr Ala Leu Ala Asn Met Val Thr Ala Leu Gln 
    210                 215                 220                 


Met Gly Ile Thr Val Phe Asp Gly Ser Ala Gly Gly Leu Gly Gly Cys 
225                 230                 235                 240 


Pro Tyr Ala Pro Gly Ser Ser Gly Asn Ala Ala Thr Glu Asp Ile Val 
                245                 250                 255     


Tyr Met Leu Glu Gln Met Asp Ile Lys Thr Asn Val Lys Leu Glu Lys 
            260                 265                 270         


Leu Leu Ser Ala Ala Lys Trp Ile Glu Glu Lys Met Gly Lys Pro Leu 
        275                 280                 285             


Pro Ser Arg Asn Leu Gln Val Phe Lys Ser Ser 
    290                 295                 


<210>  82
<211>  299
<212>  PRT
<213>  Bacillus amyloliquefaciens

<400>  82

Met Asn Cys Pro Glu Tyr Val Arg Ile Asn Glu Val Gly Pro Arg Asp 
1               5                   10                  15      


Gly Leu Gln Asn Glu Ser Ala Trp Val Asp Thr Glu Asp Lys Ile Glu 
            20                  25                  30          


Trp Ile Asn Met Leu Ser Lys Thr Gly Leu Pro Tyr Ile Glu Val Thr 
        35                  40                  45              


Ser Phe Val His Pro Arg Trp Ile Pro Ala Leu Arg Asp Ser Leu Asp 
    50                  55                  60                  


Val Ala Lys Gly Ile Ala Arg Ser Glu His Thr Val Tyr Ala Ala Leu 
65                  70                  75                  80  


Val Pro Asn Leu Ile Gly Leu Glu His Ala Ala Glu Gly Gly Ile Asp 
                85                  90                  95      


Gln Ala Cys Val Phe Leu Ser Ala Ser Glu Thr His Asn Gln Lys Asn 
            100                 105                 110         


Val Asn Lys Pro Ile Asp Arg Thr Val Gln Glu Leu Arg Arg Val Ile 
        115                 120                 125             


Thr Glu Ala Lys Ala Glu Lys Met Ala Thr Arg Ala Tyr Leu Ser Thr 
    130                 135                 140                 


Val Phe Gly Cys Pro Tyr Glu Gln Asn Val Pro Val Glu Gln Val Ile 
145                 150                 155                 160 


Arg Leu Ser Asp Thr Leu Leu Glu Met Gly Val Asp Glu Ile Ser Leu 
                165                 170                 175     


Gly Asp Thr Ile Gly Ala Ala Asn Pro Leu Gln Val Ile Ala Val Leu 
            180                 185                 190         


Glu Ala Leu Leu Pro Arg Ile Pro Ala Ser Lys Ile Ala Leu His Phe 
        195                 200                 205             


His Asp Thr Arg Gly Thr Ala Leu Ala Asn Ile Ile Pro Ala Leu Asp 
    210                 215                 220                 


Met Gly Ile Thr Ser Phe Asp Thr Ser Ser Gly Gly Leu Gly Gly Cys 
225                 230                 235                 240 


Pro Tyr Ala Pro Gly Ser Ala Gly Asn Ala Ala Thr Glu Asp Val Ile 
                245                 250                 255     


Tyr Met Leu Glu Gln Met Gly Ile Asp Thr Gly Thr Asp Met Asn Lys 
            260                 265                 270         


Leu Leu Tyr Ala Ala Gly Trp Ile Ala Asp Lys Ile Gly Lys Asp Leu 
        275                 280                 285             


Pro Ser Arg Asn Leu Gln Ala Phe Arg Thr Lys 
    290                 295                 


<210>  83
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ala Ala Met Arg Lys Ala Leu Pro Arg Arg Leu Val Gly Leu Ala 
1               5                   10                  15      


Ser Leu Arg Ala Val Ser Thr Ser Ser Met Gly Thr Leu Pro Lys Arg 
            20                  25                  30          


Val Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys 
        35                  40                  45              


Asn Ile Val Ser Thr Pro Val Lys Ile Lys Leu Ile Asp Met Leu Ser 
    50                  55                  60                  


Glu Ala Gly Leu Ser Val Ile Glu Thr Thr Ser Phe Val Ser Pro Lys 
65                  70                  75                  80  


Trp Val Pro Gln Met Gly Asp His Thr Glu Val Leu Lys Gly Ile Gln 
                85                  90                  95      


Lys Phe Pro Gly Ile Asn Tyr Pro Val Leu Thr Pro Asn Leu Lys Gly 
            100                 105                 110         


Phe Glu Ala Ala Val Ala Ala Gly Ala Lys Glu Val Val Ile Phe Gly 
        115                 120                 125             


Ala Ala Ser Glu Leu Phe Thr Lys Lys Asn Ile Asn Cys Ser Ile Glu 
    130                 135                 140                 


Glu Ser Phe Gln Arg Phe Asp Ala Ile Leu Lys Ala Ala Gln Ser Ala 
145                 150                 155                 160 


Asn Ile Ser Val Arg Gly Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr 
                165                 170                 175     


Glu Gly Lys Ile Ser Pro Ala Lys Val Ala Glu Val Thr Lys Lys Phe 
            180                 185                 190         


Tyr Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val 
        195                 200                 205             


Gly Thr Pro Gly Ile Met Lys Asp Met Leu Ser Ala Val Met Gln Glu 
    210                 215                 220                 


Val Pro Leu Ala Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln 
225                 230                 235                 240 


Ala Leu Ala Asn Thr Leu Met Ala Leu Gln Met Gly Val Ser Val Val 
                245                 250                 255     


Asp Ser Ser Val Ala Gly Leu Gly Gly Cys Pro Tyr Ala Gln Gly Ala 
            260                 265                 270         


Ser Gly Asn Leu Ala Thr Glu Asp Leu Val Tyr Met Leu Glu Gly Leu 
        275                 280                 285             


Gly Ile His Thr Gly Val Asn Leu Gln Lys Leu Leu Glu Ala Gly Asn 
    290                 295                 300                 


Phe Ile Cys Gln Ala Leu Asn Arg Lys Thr Ser Ser Lys Val Ala Gln 
305                 310                 315                 320 


Ala Thr Cys Lys Leu 
                325 


<210>  84
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Gly Asn Val Pro Ser Ala Val Lys His Cys Leu Ser Tyr Gln Gln 
1               5                   10                  15      


Leu Leu Arg Glu His Leu Trp Ile Gly Asp Ser Val Ala Gly Ala Leu 
            20                  25                  30          


Asp Pro Ala Gln Thr Ser Leu Leu Thr Asn Leu His Cys Phe Gln Pro 
        35                  40                  45              


Asp Val Ser Gly Phe Ser Val Ser Leu Ala Gly Thr Val Ala Cys Ile 
    50                  55                  60                  


His Trp Glu Thr Ser Gln Leu Ser Gly Leu Pro Glu Phe Val Lys Ile 
65                  70                  75                  80  


Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys Val Ile Val 
                85                  90                  95      


Pro Thr Asp Ile Lys Ile Glu Phe Ile Asn Arg Leu Ser Gln Thr Gly 
            100                 105                 110         


Leu Ser Val Ile Glu Val Thr Ser Phe Val Ser Ser Arg Trp Val Pro 
        115                 120                 125             


Gln Met Ala Asp His Thr Glu Val Met Lys Gly Ile His Gln Tyr Pro 
    130                 135                 140                 


Gly Val Arg Tyr Pro Val Leu Thr Pro Asn Leu Gln Gly Phe His His 
145                 150                 155                 160 


Ala Val Ala Ala Gly Ala Thr Glu Ile Ser Val Phe Gly Ala Ala Ser 
                165                 170                 175     


Glu Ser Phe Ser Lys Lys Asn Ile Asn Cys Ser Ile Glu Glu Ser Met 
            180                 185                 190         


Gly Lys Phe Glu Glu Val Val Lys Ser Ala Arg His Met Asn Ile Pro 
        195                 200                 205             


Ala Arg Gly Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr Glu Gly Ser 
    210                 215                 220                 


Ile Thr Pro Gln Lys Val Thr Glu Val Ser Lys Arg Leu Tyr Gly Met 
225                 230                 235                 240 


Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val Gly Thr Pro 
                245                 250                 255     


Gly Ser Met Lys Arg Met Leu Glu Ser Val Met Lys Glu Ile Pro Pro 
            260                 265                 270         


Gly Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln Ala Leu Ala 
        275                 280                 285             


Asn Ile Leu Thr Ala Leu Gln Met Gly Ile Asn Val Val Asp Ser Ala 
    290                 295                 300                 


Val Ser Gly Leu Gly Gly Cys Pro Tyr Ala Lys Gly Ala Ser Gly Asn 
305                 310                 315                 320 


Val Ala Thr Glu Asp Leu Ile Tyr Met Leu Asn Gly Leu Gly Leu Asn 
                325                 330                 335     


Thr Gly Val Asn Leu Tyr Lys Val Met Glu Ala Gly Asp Phe Ile Cys 
            340                 345                 350         


Lys Ala Val Asn Lys Thr Thr Asn Ser Lys Val Ala Gln Ala Ser Phe 
        355                 360                 365             


Asn Ala 
    370 


<210>  85
<211>  325
<212>  PRT
<213>  Mus musculus

<400>  85

Met Ala Ser Val Arg Lys Ala Phe Pro Arg Arg Leu Val Gly Leu Thr 
1               5                   10                  15      


Ser Leu Arg Ala Val Ser Thr Ser Ser Met Gly Thr Leu Pro Lys Gln 
            20                  25                  30          


Val Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys 
        35                  40                  45              


Ser Ile Val Pro Thr Pro Val Lys Ile Arg Leu Ile Asp Met Leu Ser 
    50                  55                  60                  


Glu Ala Gly Leu Pro Val Ile Glu Ala Thr Ser Phe Val Ser Pro Lys 
65                  70                  75                  80  


Trp Val Pro Gln Met Ala Asp His Ser Asp Val Leu Lys Gly Ile Gln 
                85                  90                  95      


Lys Phe Pro Gly Ile Asn Tyr Pro Val Leu Thr Pro Asn Met Lys Gly 
            100                 105                 110         


Phe Glu Glu Ala Val Ala Ala Gly Ala Lys Glu Val Ser Val Phe Gly 
        115                 120                 125             


Ala Val Ser Glu Leu Phe Thr Arg Lys Asn Ala Asn Cys Ser Ile Glu 
    130                 135                 140                 


Glu Ser Phe Gln Arg Phe Ala Gly Val Met Gln Ala Ala Gln Ala Ala 
145                 150                 155                 160 


Ser Ile Ser Val Arg Gly Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr 
                165                 170                 175     


Glu Gly Lys Val Ser Pro Ala Lys Val Ala Glu Val Ala Lys Lys Leu 
            180                 185                 190         


Tyr Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val 
        195                 200                 205             


Gly Thr Pro Gly Leu Met Lys Asp Met Leu Thr Ala Val Met His Glu 
    210                 215                 220                 


Val Pro Val Thr Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln 
225                 230                 235                 240 


Ala Leu Ala Asn Thr Leu Val Ala Leu Gln Met Gly Val Ser Val Val 
                245                 250                 255     


Asp Ser Ser Val Ala Gly Leu Gly Gly Cys Pro Tyr Ala Lys Gly Ala 
            260                 265                 270         


Ser Gly Asn Leu Ala Thr Glu Asp Leu Val Tyr Met Leu Asn Gly Leu 
        275                 280                 285             


Gly Ile His Thr Gly Val Asn Leu Gln Lys Leu Leu Glu Ala Gly Asp 
    290                 295                 300                 


Phe Ile Cys Gln Ala Leu Asn Arg Lys Thr Ser Ser Lys Val Ala Gln 
305                 310                 315                 320 


Ala Thr Cys Lys Leu 
                325 


<210>  86
<211>  343
<212>  PRT
<213>  Mus musculus

<400>  86

Met Gly Asn Leu Pro Ser Ala Ala Lys His Cys Leu Asn Tyr Gln Gln 
1               5                   10                  15      


Leu Leu Arg Glu His Leu Trp Ser Gly Asp Ser Val Ala Gly Ala Leu 
            20                  25                  30          


Asp Ala Ala Gln Glu Ala Ser Gln Leu Pro Gly Leu Pro Glu Tyr Val 
        35                  40                  45              


Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys Val 
    50                  55                  60                  


Ile Val Pro Thr Asp Ile Lys Ile Glu Leu Ile Asn Gln Leu Ser Gln 
65                  70                  75                  80  


Thr Gly Leu Ser Val Ile Glu Val Thr Ser Phe Val Ser Ser Arg Trp 
                85                  90                  95      


Val Pro Gln Met Ala Asp His Ala Glu Val Met Arg Gly Ile Arg Gln 
            100                 105                 110         


Tyr Pro Gly Val Arg Tyr Pro Val Leu Thr Pro Asn Leu Gln Gly Phe 
        115                 120                 125             


Gln His Ala Val Ala Ala Gly Ala Thr Glu Ile Ala Val Phe Gly Ala 
    130                 135                 140                 


Ala Ser Glu Ser Phe Ser Lys Lys Asn Ile Asn Cys Ser Ile Glu Glu 
145                 150                 155                 160 


Ser Met Gly Arg Phe Gln Glu Val Ile Ser Ser Ala Arg His Met Asp 
                165                 170                 175     


Ile Pro Val Arg Gly Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr Glu 
            180                 185                 190         


Gly Ser Ile Thr Pro Gln Lys Val Thr Glu Val Ser Lys Arg Leu Tyr 
        195                 200                 205             


Gly Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val Gly 
    210                 215                 220                 


Thr Pro Gly Ser Met Lys Met Met Leu Glu Ser Val Met Lys Glu Ile 
225                 230                 235                 240 


Pro Pro Gly Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln Ala 
                245                 250                 255     


Leu Ala Asn Ile Leu Thr Ala Leu Gln Met Gly Ile Asn Val Val Asp 
            260                 265                 270         


Ser Ala Val Ser Gly Leu Gly Gly Cys Pro Tyr Ala Lys Gly Ala Ser 
        275                 280                 285             


Gly Asn Val Ala Thr Glu Asp Leu Ile Tyr Met Leu Asn Gly Met Gly 
    290                 295                 300                 


Leu Asn Thr Gly Val Asp Leu Tyr Lys Val Met Glu Ala Gly Glu Phe 
305                 310                 315                 320 


Ile Cys Lys Ala Val Asn Lys Thr Thr Asn Ser Lys Val Ala Gln Ala 
                325                 330                 335     


Ser Phe Asn Ala Arg Leu Glu 
            340             


<210>  87
<211>  343
<212>  PRT
<213>  Rattus norvegicus

<400>  87

Met Gly Asn Leu Pro Ser Ala Ala Lys His Cys Leu Asn Tyr Gln Gln 
1               5                   10                  15      


Leu Leu Arg Glu His Leu Trp Ser Gly Glu Ser Val Ala Gly Ala Leu 
            20                  25                  30          


Asp Pro Ala Gln Glu Ala Ser Gln Leu Ser Gly Leu Pro Glu Tyr Val 
        35                  40                  45              


Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys Val 
    50                  55                  60                  


Ile Val Pro Thr Asp Ile Lys Ile Glu Phe Ile Asn Gln Leu Ser Gln 
65                  70                  75                  80  


Thr Gly Leu Ser Val Ile Glu Val Thr Ser Phe Val Ser Ser Arg Trp 
                85                  90                  95      


Val Pro Gln Met Ala Asp His Ala Glu Val Met Gly Gly Ile His Gln 
            100                 105                 110         


Tyr Pro Gly Val Arg Tyr Pro Val Leu Val Pro Asn Leu Gln Gly Leu 
        115                 120                 125             


Gln His Ala Val Ala Ala Gly Ala Thr Glu Ile Ala Val Phe Gly Ala 
    130                 135                 140                 


Ala Ser Glu Ser Phe Ser Lys Lys Asn Ile Asn Cys Ser Ile Glu Glu 
145                 150                 155                 160 


Ser Met Gly Arg Phe Glu Gln Val Ile Ser Ser Ala Arg His Met Asn 
                165                 170                 175     


Ile Pro Val Arg Gly Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr Glu 
            180                 185                 190         


Gly Ser Ile Met Pro Gln Lys Val Thr Glu Val Ser Lys Arg Leu Tyr 
        195                 200                 205             


Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Val Gly Val Gly 
    210                 215                 220                 


Thr Pro Gly Ser Met Lys Thr Met Leu Glu Ser Val Met Lys Glu Ile 
225                 230                 235                 240 


Pro Pro Gly Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln Ala 
                245                 250                 255     


Leu Ala Asn Ile Leu Thr Ala Leu Gln Met Gly Ile Asn Val Val Asp 
            260                 265                 270         


Ser Ala Val Ser Gly Leu Gly Gly Cys Pro Tyr Ala Lys Gly Ala Ser 
        275                 280                 285             


Gly Asn Val Ala Thr Glu Asp Leu Ile Tyr Met Leu Asn Gly Met Gly 
    290                 295                 300                 


Leu Asn Thr Gly Val Asp Leu His Lys Val Met Glu Ala Gly Asp Phe 
305                 310                 315                 320 


Ile Cys Lys Ala Val Asn Lys Thr Thr Asn Ser Lys Val Ala Gln Ala 
                325                 330                 335     


Ser Phe Lys Ala Arg Leu Glu 
            340             


<210>  88
<211>  468
<212>  PRT
<213>  Arabidopsis thaliana

<400>  88

Met Gln Trp Asn Gly Val Arg Arg Ala His Ser Ile Trp Cys Lys Arg 
1               5                   10                  15      


Leu Thr Asn Asn Thr His Leu His His Pro Ser Ile Pro Val Ser His 
            20                  25                  30          


Phe Phe Thr Met Ser Ser Leu Glu Glu Pro Leu Ser Phe Asp Lys Leu 
        35                  40                  45              


Pro Ser Met Ser Thr Met Asp Arg Ile Gln Arg Phe Ser Ser Gly Ala 
    50                  55                  60                  


Cys Arg Pro Arg Asp Asp Val Gly Met Gly His Arg Trp Ile Glu Gly 
65                  70                  75                  80  


Arg Asp Cys Thr Thr Ser Asn Ser Cys Ile Asp Asp Asp Lys Ser Phe 
                85                  90                  95      


Ala Lys Glu Ser Phe Pro Trp Arg Arg His Thr Arg Lys Leu Ser Glu 
            100                 105                 110         


Gly Glu His Met Phe Arg Asn Ile Ser Phe Ala Gly Arg Thr Ser Thr 
        115                 120                 125             


Val Ser Gly Thr Leu Arg Glu Ser Lys Ser Phe Lys Glu Gln Lys Tyr 
    130                 135                 140                 


Ser Thr Phe Ser Asn Glu Asn Gly Thr Ser His Ile Ser Asn Lys Ile 
145                 150                 155                 160 


Ser Lys Gly Ile Pro Lys Phe Val Lys Ile Val Glu Val Gly Pro Arg 
                165                 170                 175     


Asp Gly Leu Gln Asn Glu Lys Asn Ile Val Pro Thr Ser Val Lys Val 
            180                 185                 190         


Glu Leu Ile Gln Arg Leu Val Ser Ser Gly Leu Pro Val Val Glu Ala 
        195                 200                 205             


Thr Ser Phe Val Ser Pro Lys Trp Val Pro Gln Leu Ala Asp Ala Lys 
    210                 215                 220                 


Asp Val Met Asp Ala Val Asn Thr Leu Asp Gly Ala Arg Leu Pro Val 
225                 230                 235                 240 


Leu Thr Pro Asn Leu Lys Gly Phe Gln Ala Ala Val Ser Ala Gly Ala 
                245                 250                 255     


Lys Glu Val Ala Ile Phe Ala Ser Ala Ser Glu Ser Phe Ser Leu Ser 
            260                 265                 270         


Asn Ile Asn Cys Thr Ile Glu Glu Ser Leu Leu Arg Tyr Arg Val Val 
        275                 280                 285             


Ala Thr Ala Ala Lys Glu His Ser Val Pro Val Arg Gly Tyr Val Ser 
    290                 295                 300                 


Cys Val Val Gly Cys Pro Val Glu Gly Pro Val Leu Pro Ser Lys Val 
305                 310                 315                 320 


Ala Tyr Val Val Lys Glu Leu Tyr Asp Met Gly Cys Phe Glu Ile Ser 
                325                 330                 335     


Leu Gly Asp Thr Ile Gly Ile Gly Thr Pro Gly Ser Val Val Pro Met 
            340                 345                 350         


Leu Glu Ala Val Met Ala Val Val Pro Ala Asp Lys Leu Ala Val His 
        355                 360                 365             


Phe His Asp Thr Tyr Gly Gln Ala Leu Ala Asn Ile Leu Val Ser Leu 
    370                 375                 380                 


Gln Met Gly Ile Ser Ile Val Asp Ser Ser Ile Ala Gly Leu Gly Gly 
385                 390                 395                 400 


Cys Pro Tyr Ala Lys Gly Ala Ser Gly Asn Val Ala Thr Glu Asp Val 
                405                 410                 415     


Val Tyr Met Leu Asn Gly Leu Gly Val His Thr Asn Val Asp Leu Gly 
            420                 425                 430         


Lys Leu Ile Ala Ala Gly Asp Phe Ile Ser Lys His Leu Gly Arg Pro 
        435                 440                 445             


Asn Gly Ser Lys Ala Ala Val Ala Leu Asn Arg Arg Ile Thr Ala Asp 
    450                 455                 460                 


Ala Ser Lys Ile 
465             


<210>  89
<211>  301
<212>  PRT
<213>  Pseudomonas mevalonii

<400>  89

Met Gln Ala Val Lys Val Phe Glu Val Gly Pro Arg Asp Gly Leu Gln 
1               5                   10                  15      


Asn Glu Arg Gln Pro Leu Ser Val Ala Ala Arg Val Gly Leu Ile Gly 
            20                  25                  30          


Glu Leu Ala Gly Thr Gly Leu Arg His Ile Glu Ala Gly Ala Phe Val 
        35                  40                  45              


Ser Pro Arg Trp Val Pro Gln Met Ala Gly Ser Asp Glu Val Leu Arg 
    50                  55                  60                  


Gln Leu Pro Ser Asn Asp Gly Val Ser Tyr Thr Ala Leu Val Pro Asn 
65                  70                  75                  80  


Arg Gln Gly Phe Glu Ala Ala Gln Arg Ala Gly Cys Arg Glu Val Ala 
                85                  90                  95      


Val Phe Ala Ala Ala Ser Glu Ala Phe Ser Arg Asn Asn Ile Asn Cys 
            100                 105                 110         


Ser Ile Asp Glu Ser Phe Glu Arg Phe Thr Pro Val Leu Arg Ala Ala 
        115                 120                 125             


Asn Glu Ala Ser Ile Arg Val Arg Gly Tyr Val Ser Cys Val Leu Gly 
    130                 135                 140                 


Cys Pro Phe Ser Gly Ala Val Ala Pro Glu Ala Val Ala Lys Val Ala 
145                 150                 155                 160 


Arg Arg Leu Tyr Glu Leu Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr 
                165                 170                 175     


Ile Gly Ala Gly Arg Pro Asp Glu Thr Ala Gln Leu Phe Glu Leu Cys 
            180                 185                 190         


Ala Arg Gln Leu Pro Val Ala Ala Leu Ala Gly His Phe His Asp Thr 
        195                 200                 205             


Trp Gly Met Ala Ile Ala Asn Val His Ala Ala Leu Ala Gln Gly Val 
    210                 215                 220                 


Arg Thr Phe Asp Ser Ser Val Ala Gly Leu Gly Gly Cys Pro Tyr Ser 
225                 230                 235                 240 


Pro Gly Ala Ser Gly Asn Val Ala Thr Glu Asp Leu Leu Tyr Leu Leu 
                245                 250                 255     


His Gly Leu Gly Tyr Ser Thr Gly Val Asp Leu Glu Ala Val Ala Gln 
            260                 265                 270         


Val Gly Val Arg Ile Ser Ala Gln Leu Gly Thr Ala Asn Arg Ser Arg 
        275                 280                 285             


Ala Gly Leu Ala Leu Ala Ala Arg Ser Ala Arg Glu His 
    290                 295                 300     


<210>  90
<211>  325
<212>  PRT
<213>  Rattus norvegicus

<400>  90

Met Ala Thr Val Arg Lys Ala Phe Pro Gln Arg Leu Val Gly Leu Ala 
1               5                   10                  15      


Ser Leu Arg Ala Ala Ser Thr Ser Ser Met Gly Thr Leu Pro Lys Arg 
            20                  25                  30          


Val Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys 
        35                  40                  45              


Ser Ile Val Pro Thr Pro Val Lys Ile Lys Leu Ile Asp Met Leu Ser 
    50                  55                  60                  


Glu Ala Gly Leu Pro Val Ile Glu Ala Thr Ser Phe Val Ser Pro Lys 
65                  70                  75                  80  


Trp Val Pro Gln Met Ala Asp His Ser Asp Val Leu Lys Gly Ile Gln 
                85                  90                  95      


Lys Phe Pro Gly Ile Asn Tyr Pro Val Leu Thr Pro Asn Met Lys Gly 
            100                 105                 110         


Phe Glu Glu Ala Val Ala Ala Gly Ala Lys Glu Val Ser Ile Phe Gly 
        115                 120                 125             


Ala Ala Ser Glu Leu Phe Thr Arg Lys Asn Val Asn Cys Ser Ile Glu 
    130                 135                 140                 


Glu Ser Phe Gln Arg Phe Asp Gly Val Met Gln Ala Ala Arg Ala Ala 
145                 150                 155                 160 


Ser Ile Ser Val Arg Gly Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr 
                165                 170                 175     


Glu Gly Lys Val Ser Pro Ala Lys Val Ala Glu Val Ala Lys Lys Leu 
            180                 185                 190         


Tyr Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val 
        195                 200                 205             


Gly Thr Pro Gly Leu Met Lys Asp Met Leu Thr Ala Val Leu His Glu 
    210                 215                 220                 


Val Pro Val Ala Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln 
225                 230                 235                 240 


Ala Leu Ala Asn Thr Leu Val Ala Leu Gln Met Gly Val Ser Val Val 
                245                 250                 255     


Asp Ser Ser Val Ala Gly Leu Gly Gly Cys Pro Tyr Ala Lys Gly Ala 
            260                 265                 270         


Ser Gly Asn Leu Ala Thr Glu Asp Leu Val Tyr Met Leu Thr Gly Leu 
        275                 280                 285             


Gly Ile His Thr Gly Val Asn Leu Gln Lys Leu Leu Glu Ala Gly Asp 
    290                 295                 300                 


Phe Ile Cys Gln Ala Leu Asn Arg Lys Thr Ser Ser Lys Val Ala Gln 
305                 310                 315                 320 


Ala Thr Cys Lys Leu 
                325 


<210>  91
<211>  325
<212>  PRT
<213>  Bos taurus

<400>  91

Met Ala Thr Val Lys Lys Val Leu Pro Arg Arg Leu Val Gly Leu Ala 
1               5                   10                  15      


Thr Leu Arg Ala Val Ser Thr Ser Ser Val Gly Thr Phe Pro Lys Gln 
            20                  25                  30          


Val Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys 
        35                  40                  45              


Asn Ile Val Pro Thr Pro Val Lys Ile Lys Leu Ile Asp Met Leu Ser 
    50                  55                  60                  


Glu Ala Gly Leu Pro Val Val Glu Ala Thr Ser Phe Val Ser Pro Lys 
65                  70                  75                  80  


Trp Val Pro Gln Met Ala Asp His Ala Glu Val Leu Lys Gly Ile Gln 
                85                  90                  95      


Lys Phe Pro Gly Val Asn Tyr Pro Val Leu Thr Pro Asn Phe Lys Gly 
            100                 105                 110         


Phe Gln Ala Ala Val Ala Ala Gly Ala Lys Glu Val Ala Ile Phe Gly 
        115                 120                 125             


Ala Ala Ser Glu Leu Phe Thr Lys Lys Asn Ile Asn Cys Ser Ile Asp 
    130                 135                 140                 


Glu Ser Leu Gln Arg Phe Asp Glu Ile Leu Lys Ala Ala Arg Ala Ala 
145                 150                 155                 160 


Gly Ile Ser Val Arg Gly Tyr Val Ser Cys Val Leu Gly Cys Pro Tyr 
                165                 170                 175     


Glu Gly Lys Ile Ser Pro Ala Lys Val Ala Glu Val Thr Lys Lys Leu 
            180                 185                 190         


Tyr Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val 
        195                 200                 205             


Gly Thr Pro Gly Ala Met Lys Asp Met Leu Ser Ala Val Leu Gln Glu 
    210                 215                 220                 


Val Pro Val Thr Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln 
225                 230                 235                 240 


Ala Leu Ala Asn Thr Leu Thr Ala Leu Gln Met Gly Val Ser Val Met 
                245                 250                 255     


Asp Ser Ser Val Ala Gly Leu Gly Gly Cys Pro Tyr Ala Gln Gly Ala 
            260                 265                 270         


Ser Gly Asn Leu Ala Thr Glu Asp Leu Val Tyr Met Leu Ala Gly Leu 
        275                 280                 285             


Gly Ile His Thr Gly Val Asn Leu Gln Lys Leu Leu Glu Ala Gly Ala 
    290                 295                 300                 


Phe Ile Cys Gln Ala Leu Asn Arg Arg Thr Asn Ser Lys Val Ala Gln 
305                 310                 315                 320 


Ala Thr Cys Lys Leu 
                325 


<210>  92
<211>  298
<212>  PRT
<213>  Gallus gallus

<400>  92

Ala Phe Pro Gln Arg Val Lys Val Val Glu Val Gly Pro Arg Asp Gly 
1               5                   10                  15      


Leu Gln Asn Glu Lys Ser Val Val Pro Thr Pro Val Lys Ile Arg Leu 
            20                  25                  30          


Ile Asp Met Leu Ser Glu Thr Gly Leu Pro Val Ile Glu Ala Thr Ser 
        35                  40                  45              


Phe Val Ser Pro Arg Trp Val Pro Gln Met Ala Asp His Ala Glu Val 
    50                  55                  60                  


Met Gln Gly Ile Asn Lys Leu Pro Gly Val Ser Tyr Pro Val Leu Thr 
65                  70                  75                  80  


Pro Asn Leu Lys Gly Phe Gln Ala Ala Val Ala Ala Gly Ala Lys Glu 
                85                  90                  95      


Val Ser Ile Phe Gly Ala Ala Ser Glu Leu Phe Thr Lys Lys Asn Ile 
            100                 105                 110         


Asn Cys Ser Ile Glu Glu Ser Leu Glu Arg Phe Ser Glu Val Met Asn 
        115                 120                 125             


Ala Ala Arg Ala Ala Ser Ile Pro Val Arg Gly Tyr Val Ser Cys Val 
    130                 135                 140                 


Leu Gly Cys Pro Tyr Glu Gly Asn Ile Ser Ala Ala Lys Val Ala Glu 
145                 150                 155                 160 


Val Ser Lys Lys Met Tyr Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly 
                165                 170                 175     


Asp Arg Ile Gly Ile Gly Thr Pro Gly Ser Met Lys Glu Met Leu Ala 
            180                 185                 190         


Ala Val Met Lys Glu Val Pro Val Gly Ala Leu Ala Val His Cys His 
        195                 200                 205             


Asp Thr Tyr Gly Gln Ala Leu Ala Asn Ile Leu Val Ala Leu Gln Met 
    210                 215                 220                 


Gly Val Ser Val Val Asp Ala Ser Val Ala Gly Leu Gly Gly Cys Pro 
225                 230                 235                 240 


Tyr Ala Gln Gly Ala Ser Gly Asn Val Ala Thr Glu Asp Leu Val Tyr 
                245                 250                 255     


Met Leu Asn Gly Leu Gly Ile His Thr Gly Val Asp Leu Gln Lys Leu 
            260                 265                 270         


Met Asp Thr Gly Thr Phe Ile Cys Asn Ala Leu Asn Arg Arg Thr Asn 
        275                 280                 285             


Ser Lys Val Ser Gln Ala Ala Cys Arg Leu 
    290                 295             


<210>  93
<211>  335
<212>  PRT
<213>  Danio rerio

<400>  93

Met Gly Asn Val Ser Ser Ala Val Lys His Cys Leu Ser Tyr Glu Thr 
1               5                   10                  15      


Phe Leu Arg Asp Tyr Pro Trp Leu Pro Arg Leu Leu Trp Glu Glu Lys 
            20                  25                  30          


Cys Ser Glu Leu Pro Lys Leu Pro Val Tyr Val Lys Ile Val Glu Val 
        35                  40                  45              


Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys Glu Ile Val Pro Thr Glu 
    50                  55                  60                  


Val Lys Ile Gln Leu Ile Asp Leu Leu Ser Gln Thr Gly Leu Pro Val 
65                  70                  75                  80  


Ile Glu Ala Thr Ser Phe Val Ser Ser Lys Trp Val Ala Gln Met Ala 
                85                  90                  95      


Asp His Thr Ala Val Leu Lys Gly Ile Lys Arg Ser Pro Asp Val Arg 
            100                 105                 110         


Tyr Pro Val Leu Thr Pro Asn Ile Gln Gly Phe Gln Ala Ala Val Ala 
        115                 120                 125             


Ala Gly Ala Asn Glu Val Ala Val Phe Gly Ser Ala Ser Glu Thr Phe 
    130                 135                 140                 


Ser Arg Lys Asn Ile Asn Cys Ser Ile Glu Glu Ser Leu Gln Arg Phe 
145                 150                 155                 160 


Glu Gln Val Val Ser Ala Ala Lys Gln Glu Gly Ile Pro Val Arg Gly 
                165                 170                 175     


Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr Glu Gly Gln Val Lys Pro 
            180                 185                 190         


Ser Gln Val Thr Lys Val Ala Lys Arg Leu Phe Glu Leu Gly Cys Tyr 
        195                 200                 205             


Glu Val Ser Leu Gly Asp Thr Ile Gly Val Gly Thr Ala Gly Ser Met 
    210                 215                 220                 


Ala Glu Met Leu Ser Asp Val Leu Thr Glu Val Pro Ala Gly Ala Leu 
225                 230                 235                 240 


Ala Val His Cys His Asp Thr Tyr Gly Gln Ala Leu Pro Asn Ile Leu 
                245                 250                 255     


Ile Ala Leu Gln Met Gly Val Ser Val Val Asp Ala Ser Val Ala Gly 
            260                 265                 270         


Leu Gly Gly Cys Pro Phe Ala Lys Gly Ala Ser Gly Asn Val Ser Thr 
        275                 280                 285             


Glu Asp Leu Leu Tyr Met Leu His Gly Leu Gly Ile Glu Thr Gly Val 
    290                 295                 300                 


Asp Leu Leu Lys Val Met Glu Ala Gly Asp Phe Ile Cys Lys Ala Leu 
305                 310                 315                 320 


Asn Arg Lys Thr Asn Ser Lys Val Ser Gln Ala Thr Arg Asn Asn 
                325                 330                 335 


<210>  94
<211>  325
<212>  PRT
<213>  Macaca fascicularis

<400>  94

Met Ala Ala Met Thr Lys Ala Leu Pro Arg Arg Leu Val Gly Leu Ala 
1               5                   10                  15      


Ser Leu Arg Ala Val Ser Thr Ser Ser Met Asp Thr Leu Pro Lys Gln 
            20                  25                  30          


Val Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys 
        35                  40                  45              


Asn Ile Val Ser Thr Pro Val Lys Ile Lys Leu Ile Asp Met Leu Ser 
    50                  55                  60                  


Glu Ala Gly Leu Ser Val Ile Glu Ala Thr Ser Phe Val Ser Pro Lys 
65                  70                  75                  80  


Trp Val Pro Gln Met Ala Asp His Ala Glu Val Leu Lys Gly Ile Gln 
                85                  90                  95      


Lys Phe Pro Gly Ile Thr Tyr Pro Val Leu Ile Pro Asn Leu Lys Gly 
            100                 105                 110         


Phe Glu Ala Ala Val Ala Ala Gly Ala Lys Glu Val Ser Ile Phe Gly 
        115                 120                 125             


Ala Ala Ser Glu Leu Phe Thr Lys Lys Asn Val Asn Cys Ser Ile Glu 
    130                 135                 140                 


Glu Ser Phe Gln Arg Phe Asp Ala Ile Leu Lys Ala Ala Gln Ser Ala 
145                 150                 155                 160 


Asn Ile Ser Val Arg Gly Tyr Val Ser Cys Val Leu Gly Cys Pro Tyr 
                165                 170                 175     


Glu Gly Lys Ile Ser Pro Ala Lys Val Ala Glu Val Thr Lys Lys Phe 
            180                 185                 190         


Tyr Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val 
        195                 200                 205             


Gly Thr Pro Gly Ile Met Lys Asp Met Leu Ser Ala Val Met Gln Glu 
    210                 215                 220                 


Val Pro Pro Ala Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln 
225                 230                 235                 240 


Ala Leu Ala Asn Thr Leu Met Ala Leu Gln Met Gly Val Ser Val Val 
                245                 250                 255     


Asp Ser Ser Val Ala Gly Leu Gly Gly Cys Pro Tyr Ala Gln Gly Ala 
            260                 265                 270         


Ser Gly Asn Leu Ala Thr Glu Asp Leu Val Tyr Met Leu Glu Gly Leu 
        275                 280                 285             


Gly Ile His Thr Gly Val Asn Leu Gln Lys Leu Leu Glu Ala Gly Asn 
    290                 295                 300                 


Phe Ile Cys Gln Ala Leu Asn Arg Lys Thr Ser Ser Lys Val Ala Gln 
305                 310                 315                 320 


Ala Thr Cys Lys Leu 
                325 


<210>  95
<211>  325
<212>  PRT
<213>  Pongo abelii

<400>  95

Met Ala Ala Met Arg Lys Ala Val Pro Arg Arg Leu Val Gly Leu Ala 
1               5                   10                  15      


Ser Leu Arg Ala Val Ser Thr Ser Ser Met Gly Thr Leu Pro Lys Arg 
            20                  25                  30          


Val Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys 
        35                  40                  45              


Asn Ile Val Ser Thr Pro Val Lys Ile Lys Leu Ile Asp Met Leu Ser 
    50                  55                  60                  


Glu Ala Gly Leu Ser Val Ile Glu Thr Thr Ser Phe Val Ser Pro Lys 
65                  70                  75                  80  


Trp Val Pro Gln Met Gly Asp His Thr Glu Val Leu Lys Gly Ile Gln 
                85                  90                  95      


Lys Phe Pro Gly Ile Asn Tyr Pro Val Leu Thr Pro Asn Leu Lys Gly 
            100                 105                 110         


Phe Glu Ala Ala Val Ala Ala Gly Ala Lys Glu Val Ala Ile Phe Gly 
        115                 120                 125             


Ala Ala Ser Glu Leu Phe Thr Lys Lys Asn Ile Asn Cys Ser Ile Glu 
    130                 135                 140                 


Glu Ser Phe Gln Arg Phe Asp Ala Ile Leu Lys Ala Ala Gln Ser Ala 
145                 150                 155                 160 


Asn Ile Ser Val Arg Gly Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr 
                165                 170                 175     


Glu Gly Lys Ile Ser Pro Ala Lys Val Ala Glu Val Thr Lys Lys Leu 
            180                 185                 190         


Tyr Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val 
        195                 200                 205             


Gly Thr Pro Gly Ile Met Lys Gly Met Leu Ser Ala Val Met Gln Glu 
    210                 215                 220                 


Val Pro Leu Ala Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln 
225                 230                 235                 240 


Ala Leu Ala Asn Thr Leu Met Ala Leu Gln Met Gly Val Ser Val Val 
                245                 250                 255     


Asp Ser Ser Val Ala Gly Leu Gly Gly Cys Pro Tyr Ala Gln Gly Ala 
            260                 265                 270         


Ser Gly Asn Leu Ala Thr Glu Asp Leu Val Tyr Met Leu Glu Gly Leu 
        275                 280                 285             


Gly Ile His Thr Gly Val Asn Leu Gln Lys Leu Leu Glu Ala Gly Asn 
    290                 295                 300                 


Phe Ile Cys Gln Ala Leu Asn Arg Lys Thr Ser Ser Lys Val Ala Gln 
305                 310                 315                 320 


Ala Thr Cys Lys Leu 
                325 


