                         SEQUENCE LISTING

<110>  Santaris Pharma A/S
 
<120>  OLIGONUCLEOTIDE CONJUGATES

<130>  1138WO

<150>  EP12192773.5
<151>  2012-11-15

<150>  EP13153296.2
<151>  2013-01-30

<150>  EP13157237.2
<151>  2013-02-28

<150>  EP13174092.0
<151>  2013-06-27

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  1
gcattggtat tca                                                          13


<210>  2
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  2
gcattggtat tca                                                          13


<210>  3
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  disulphide linked 5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  3
gcattggtat tca                                                          13


<210>  4
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  4
tcagcattgg tattca                                                       16


<210>  5
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  5
cagcattggt attca                                                        15


<210>  6
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (2)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  6
agcattggta ttca                                                         14


<210>  7
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  7
gtctgtggaa gcg                                                          13


<210>  8
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  8
gtctgtggaa gcg                                                          13


<210>  9
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  9
cagtctgtgg aagcg                                                        15


<210>  10
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  10
ctgtctgtgg aagcg                                                        15


<210>  11
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  11
nnnnnnnnnn nnn                                                          13


<210>  12
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 GalNac cluster conjugate (Conj1a)

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  12
nnnnnnnnnn nnn                                                          13


<210>  13
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 GalNac cluster conjugate (Conj1a)

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  13
cannnnnnnn nnnnn                                                        15


<210>  14
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  disulphide linked 5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  14
nnnnnnnnnn nnn                                                          13


<210>  15
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  15
cannnnnnnn nnnnn                                                        15


<210>  16
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  16
tcagcattgg tattca                                                       16


<210>  17
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  17
cagcattggt attca                                                        15


<210>  18
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (2)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  18
agcattggta ttca                                                         14


<210>  19
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  19
gacgcattgg tattca                                                       16


<210>  20
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  20
gcattggtat tca                                                          13


<210>  21
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide + PO linker blocker


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (19)..(27)
<223>  phosphorothioate lnternucleoside linkages

<400>  21
nnnnnnnnnn gcnnnnnnnn nnnnnnn                                           27


<210>  22
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  22
nnnnnnnnnn nnnnnnnnnn nnnnnnn                                           27


<210>  23
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide + PO linker blocker


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (19)..(27)
<223>  phosphorothioate lnternucleoside linkages

<400>  23
nnnnnnnnnn gcnnnnnnnn nnnnnnn                                           27


<210>  24
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  24
nnnnnnnnnn nnnnnnnnnn nnnnnnn                                           27


<210>  25
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 folic acid conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  25
gcattggtat tca                                                          13


<210>  26
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 disulphide linked folic acid conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  26
gcattggtat tca                                                          13


<210>  27
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 folic acid conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  27
cagcattggt attca                                                        15


<210>  28
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 mono galnac conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  28
gcattggtat tca                                                          13


<210>  29
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 disulphide linked mono galnac conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  29
gcattggtat tca                                                          13


<210>  30
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 mono galnac conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  30
cagcattggt attca                                                        15


<210>  31
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  31
gcattggtat tca                                                          13


<210>  32
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 disulphide linked FAM conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  32
gcattggtat tca                                                          13


<210>  33
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  33
cagcattggt attca                                                        15


<210>  34
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 tocopherol conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  34
gcattggtat tca                                                          13


<210>  35
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 disulphide linked tocopherol conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  35
gcattggtat tca                                                          13


<210>  36
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 tocopherol conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  36
cagcattggt attca                                                        15


<210>  37
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  37
tgctacaaaa ccca                                                         14


<210>  38
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  38
aatgctacaa aaccca                                                       16


<210>  39
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  39
aatgctacaa aaccca                                                       16


<210>  40
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  40
gctgtgtgag cttgg                                                        15


<210>  41
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  41
tgctgtgtga gcttgg                                                       16


<210>  42
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  42
tgctgtgtga gcttgg                                                       16


<210>  43
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  43
tcctggtctg tgttcc                                                       16


<210>  44
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  44
tcctggtctg tgttcc                                                       16


<210>  45
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  45
cacatgctac aaaaccca                                                     18


<210>  46
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  46
caaatgctac aaaaccca                                                     18


<210>  47
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  47
caaatgctac aaaaccca                                                     18


<210>  48
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(17)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  48
cagctgtgtg agcttgg                                                      17


<210>  49
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  49
catgctgtgt gagcttgg                                                     18


<210>  50
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  50
catgctgtgt gagcttgg                                                     18


<210>  51
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  51
catcctggtc tgtgttcc                                                     18


<210>  52
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  52
catcctggtc tgtgttcc                                                     18


<210>  53
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  53
gttgacactg tc                                                           12


<210>  54
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  54
cagttgacac tgtc                                                         14


