                         SEQUENCE LISTING

<110>  Urifer Ltd.
 
<120>  DRUG COMBINATION COMPRISING A GLYCOLYSIS INHIBITOR AND A TYROSINE
        KINASE INHIBITOR

<130>  2186595

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  2950
<212>  DNA
<213>  Homo sapiens

<400>  1
gtcacaccct cgaataatga cgcataccta tcctactgtt actgatcacc tagtaataat       60

cttgtagttc acattactca tttttcacca aattcttttg gtgaaggacg cttcagaaac      120

ggccatcact gaagagcaga cccgtttggg ttctccacgc attctagact cccgaagagc      180

tcatgttttt tggctagacc tatgaccatt ttcgctagac ttcactgcac gttttctcaa      240

gtatcttctt tgtccctaat gtgtgacacc tcatcatgga cacgctactt tagctaaggc      300

atgaccagca atgaacagta gtaagatatg tgctgattag aaggctcact tgtgcagtgt      360

ggaggataac cagtgcctta caaaatgggg tttgggagtg acctgaagaa ttcacatgaa      420

gcagtgttaa aattgcaaga ctgggaatta cggttactgg aaacagtaaa gaaatttatg      480

gccctgagaa taaaaagtga taaagaatat gcatctactt tacagaacct ttgtaatcaa      540

gttgataagg aaagtactgt ccaaatgaat tatgtcagca acgtatccaa gtcttggcta      600

cttatgattc agcagacaga acaacttagt aggataatga agacacatgc agaggacttg      660

aactctggac ctttacacag gctcaccatg atgattaagg acaagcagca ggtgaagaaa      720

agttacatag gtgttcatca gcagatagag gcagagatga tcaaggttac caaaacagaa      780

ttggagaagt taaaatgcag ctatagacaa ttaataaaag aaatgaattc tgccaaagag      840

aaatataaag aagctttagc taaagggaag gaaactgaaa aggccaagga acgatacgac      900

aaagccacaa tgaaacttca tatgttgcac aatcagtatg tattggcgtt gaaaggggca      960

cagctccatc agaatcagta ttatgatatc acacttcccc tgcttctgga ctccttacaa     1020

aagatgcaag aagaaatgat aaaagcactc aaaggtatat ttgatgaata cagccagata     1080

accagtcttg tcacagagga aatagtgaat gtccataaag agattcaaat gtcggttgaa     1140

cagatagatc ctagtacaga atacaataat ttcatagatg ttcacagaac aacggctgct     1200

aaagaacaag aaatagagtt tgatacttcc ttactggaag aaaatgaaaa tcttcaggca     1260

aatgagatca tgtggaataa cttaacagca gaaagtttgc aagtaatgtt gaaaacgtta     1320

gcggaagaac ttatgcaaac acagcagatg cttttaaaca aggaggaggc tgttttggag     1380

ttagagaaga gaattgaaga atcttctgaa acttgtgaga agaagtctga tattgtgctt     1440

ctgctaagcc aaaaacaggc acttgaagaa ctgaaacagt cagtccagca gctgagatgc     1500

actgaagcaa agttttcagc acagaaggaa ttactagagc aaaaagtgca agaaaatgat     1560

gggaaagagc cacctccagt agtaaattat gaagaagatg cacgatcagt tacatctatg     1620

gaaagaaagg agaggctatc caaatttgaa tctattcgtc attcaattgc tggaataatt     1680

aggtctccaa aatctgcact gggctcttca gcactttctg atatgatctc catcagtgag     1740

aagcctttgg cagaacagga ctggtaccat ggtgcaattc ccagaataga agctcaagaa     1800

ctgttaaaaa aacaaggaga ctttttggtg cgagagagtc atgggaaacc tggtgaatat     1860

gtcctttctg tatattctga tggacagagg agacatttta tcatacaata tgttgataac     1920

atgtatcgat tcgagggcac tgggttttca aacattcctc aacttataga tcatcactat     1980

acaacaaaac aggtcatcac taagaaatca ggtgtagttc tgctgaatcc tattcctaag     2040

gacaagaaat ggattctcag tcatgaagat gtcatattgg gagaattact gggcaaggga     2100

aattttggtg aagtatataa gggcacatta aaggataaaa cttctgttgc tgttaaaaca     2160

tgtaaagaag atcttcctca ggaattgaaa ataaaatttt tacaagaagc caaaattctc     2220

aagcaatatg atcatcccaa tattgtcaaa cttataggag tttgcacaca aagacagcct     2280

gtctacatca ttatggaact ggtttcagga ggtgatttcc tcacctttct gagaaggaag     2340

aaggatgaac taaaactcaa acagttagtg aaattttcat tagacgctgc tgctggtatg     2400

ttgtatctcg agagtaaaaa ctgtatacac agggaccttg ctgcaagaaa ctgcctggta     2460

ggtgaaaata atgttctgaa aatcagtgac tttggaatgt ctcgtcaaga ggatggtgga     2520

gtgtattcat cttctggctt aaagcagatt cccattaaat ggacagcacc ggaagctctt     2580

aattatggga gatacagttc agagagtgac gtgtggagct ttggcatcct tctctgggag     2640

accttcagct taggggtttg tccgtaccct ggaatgacaa atcagcaagc aagagagcaa     2700

gtagaaagag gataccggat gtcagctccc cagcactgtc cagaggatat ttccaaaatc     2760

atgatgaagt gttgggatta taaacctgaa aatcgcccta agttcagtga acttcagaaa     2820

gagctcacta tcatcaagag aaaactcaca tagtgacagg atggcgccaa actcagcctt     2880

caggactctg tcctccagca gagtaacatt attgttctca ttaacaatga atttatacca     2940

cattaccttc                                                            2950


<210>  2
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Phe Gly Ser Asp Leu Lys Asn Ser His Glu Ala Val Leu Lys 
1               5                   10                  15      


Leu Gln Asp Trp Glu Leu Arg Leu Leu Glu Thr Val Lys Lys Phe Met 
            20                  25                  30          


Ala Leu Arg Ile Lys Ser Asp Lys Glu Tyr Ala Ser Thr Leu Gln Asn 
        35                  40                  45              


Leu Cys Asn Gln Val Asp Lys Glu Ser Thr Val Gln Met Asn Tyr Val 
    50                  55                  60                  


Ser Asn Val Ser Lys Ser Trp Leu Leu Met Ile Gln Gln Thr Glu Gln 
65                  70                  75                  80  


Leu Ser Arg Ile Met Lys Thr His Ala Glu Asp Leu Asn Ser Gly Pro 
                85                  90                  95      


Leu His Arg Leu Thr Met Met Ile Lys Asp Lys Gln Gln Val Lys Lys 
            100                 105                 110         


Ser Tyr Ile Gly Val His Gln Gln Ile Glu Ala Glu Met Ile Lys Val 
        115                 120                 125             


Thr Lys Thr Glu Leu Glu Lys Leu Lys Cys Ser Tyr Arg Gln Leu Ile 
    130                 135                 140                 


Lys Glu Met Asn Ser Ala Lys Glu Lys Tyr Lys Glu Ala Leu Ala Lys 
145                 150                 155                 160 


Gly Lys Glu Thr Glu Lys Ala Lys Glu Arg Tyr Asp Lys Ala Thr Met 
                165                 170                 175     


Lys Leu His Met Leu His Asn Gln Tyr Val Leu Ala Leu Lys Gly Ala 
            180                 185                 190         


Gln Leu His Gln Asn Gln Tyr Tyr Asp Ile Thr Leu Pro Leu Leu Leu 
        195                 200                 205             


Asp Ser Leu Gln Lys Met Gln Glu Glu Met Ile Lys Ala Leu Lys Gly 
    210                 215                 220                 


Ile Phe Asp Glu Tyr Ser Gln Ile Thr Ser Leu Val Thr Glu Glu Ile 
225                 230                 235                 240 


Val Asn Val His Lys Glu Ile Gln Met Ser Val Glu Gln Ile Asp Pro 
                245                 250                 255     


Ser Thr Glu Tyr Asn Asn Phe Ile Asp Val His Arg Thr Thr Ala Ala 
            260                 265                 270         


Lys Glu Gln Glu Ile Glu Phe Asp Thr Ser Leu Leu Glu Glu Asn Glu 
        275                 280                 285             


Asn Leu Gln Ala Asn Glu Ile Met Trp Asn Asn Leu Thr Ala Glu Ser 
    290                 295                 300                 


Leu Gln Val Met Leu Lys Thr Leu Ala Glu Glu Leu Met Gln Thr Gln 
305                 310                 315                 320 


Gln Met Leu Leu Asn Lys Glu Glu Ala Val Leu Glu Leu Glu Lys Arg 
                325                 330                 335     


Ile Glu Glu Ser Ser Glu Thr Cys Glu Lys Lys Ser Asp Ile Val Leu 
            340                 345                 350         


Leu Leu Ser Gln Lys Gln Ala Leu Glu Glu Leu Lys Gln Ser Val Gln 
        355                 360                 365             


Gln Leu Arg Cys Thr Glu Ala Lys Phe Ser Ala Gln Lys Glu Leu Leu 
    370                 375                 380                 


Glu Gln Lys Val Gln Glu Asn Asp Gly Lys Glu Pro Pro Pro Val Val 
385                 390                 395                 400 


Asn Tyr Glu Glu Asp Ala Arg Ser Val Thr Ser Met Glu Arg Lys Glu 
                405                 410                 415     


Arg Leu Ser Lys Phe Glu Ser Ile Arg His Ser Ile Ala Gly Ile Ile 
            420                 425                 430         


Arg Ser Pro Lys Ser Ala Leu Gly Ser Ser Ala Leu Ser Asp Met Ile 
        435                 440                 445             


Ser Ile Ser Glu Lys Pro Leu Ala Glu Gln Asp Trp Tyr His Gly Ala 
    450                 455                 460                 


Ile Pro Arg Ile Glu Ala Gln Glu Leu Leu Lys Lys Gln Gly Asp Phe 
465                 470                 475                 480 


Leu Val Arg Glu Ser His Gly Lys Pro Gly Glu Tyr Val Leu Ser Val 
                485                 490                 495     


Tyr Ser Asp Gly Gln Arg Arg His Phe Ile Ile Gln Tyr Val Asp Asn 
            500                 505                 510         


Met Tyr Arg Phe Glu Gly Thr Gly Phe Ser Asn Ile Pro Gln Leu Ile 
        515                 520                 525             


Asp His His Tyr Thr Thr Lys Gln Val Ile Thr Lys Lys Ser Gly Val 
    530                 535                 540                 


Val Leu Leu Asn Pro Ile Pro Lys Asp Lys Lys Trp Ile Leu Ser His 
545                 550                 555                 560 


Glu Asp Val Ile Leu Gly Glu Leu Leu Gly Lys Gly Asn Phe Gly Glu 
                565                 570                 575     


Val Tyr Lys Gly Thr Leu Lys Asp Lys Thr Ser Val Ala Val Lys Thr 
            580                 585                 590         


Cys Lys Glu Asp Leu Pro Gln Glu Leu Lys Ile Lys Phe Leu Gln Glu 
        595                 600                 605             


Ala Lys Ile Leu Lys Gln Tyr Asp His Pro Asn Ile Val Lys Leu Ile 
    610                 615                 620                 


Gly Val Cys Thr Gln Arg Gln Pro Val Tyr Ile Ile Met Glu Leu Val 
625                 630                 635                 640 


Ser Gly Gly Asp Phe Leu Thr Phe Leu Arg Arg Lys Lys Asp Glu Leu 
                645                 650                 655     


Lys Leu Lys Gln Leu Val Lys Phe Ser Leu Asp Ala Ala Ala Gly Met 
            660                 665                 670         


Leu Tyr Leu Glu Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg 
        675                 680                 685             


Asn Cys Leu Val Gly Glu Asn Asn Val Leu Lys Ile Ser Asp Phe Gly 
    690                 695                 700                 


Met Ser Arg Gln Glu Asp Gly Gly Val Tyr Ser Ser Ser Gly Leu Lys 
705                 710                 715                 720 


Gln Ile Pro Ile Lys Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg 
                725                 730                 735     


Tyr Ser Ser Glu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu 
            740                 745                 750         


Thr Phe Ser Leu Gly Val Cys Pro Tyr Pro Gly Met Thr Asn Gln Gln 
        755                 760                 765             


Ala Arg Glu Gln Val Glu Arg Gly Tyr Arg Met Ser Ala Pro Gln His 
    770                 775                 780                 


Cys Pro Glu Asp Ile Ser Lys Ile Met Met Lys Cys Trp Asp Tyr Lys 
785                 790                 795                 800 


Pro Glu Asn Arg Pro Lys Phe Ser Glu Leu Gln Lys Glu Leu Thr Ile 
                805                 810                 815     


Ile Lys Arg Lys Leu Thr 
            820         


<210>  3
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Gln Lys Met Lys Cys Pro His Cys Lys Asp Gln Leu Glu Ser 
1               5                   10                  15      


Gly Phe Gly Ser Gln Ser Cys Lys Thr Cys Ala Leu Met Phe Ser Ser 
            20                  25                  30          


Glu Pro Ser Thr Ser Glu Val His Arg Asp Gln Glu Arg Lys Glu Arg 
        35                  40                  45              


Leu Ser Lys Phe Glu Ser Ile Arg His Ser Ile Ala Gly Ile Ile Arg 
    50                  55                  60                  


Ser Pro Lys Ser Ala Leu Gly Ser Ser Ala Leu Ser Asp Met Ile Ser 
65                  70                  75                  80  


Ile Ser Glu Lys Pro Leu Ala Glu Gln Asp Trp Tyr His Gly Ala Ile 
                85                  90                  95      


Pro Arg Ile Glu Ala Gln Glu Leu Leu Lys Lys Gln Gly Asp Phe Leu 
            100                 105                 110         


Val Arg Glu Ser His Gly Lys Pro Gly Glu Tyr Val Leu Ser Val Tyr 
        115                 120                 125             


Ser Asp Gly Gln Arg Arg His Phe Ile Ile Gln Tyr Val Asp Asn Met 
    130                 135                 140                 


Tyr Arg Phe Glu Gly Thr Gly Phe Ser Asn Ile Pro Gln Leu Ile Asp 
145                 150                 155                 160 


His His Tyr Thr Thr Lys Gln Val Ile Thr Lys Lys Ser Gly Val Val 
                165                 170                 175     


Leu Leu Asn Pro Ile Pro Lys Asp Lys Lys Trp Ile Leu Ser His Glu 
            180                 185                 190         


Asp Val Ile Leu Gly Glu Leu Leu Gly Lys Gly Asn Phe Gly Glu Val 
        195                 200                 205             


Tyr Lys Gly Thr Leu Lys Asp Lys Thr Ser Val Ala Val Lys Thr Cys 
    210                 215                 220                 


Lys Glu Asp Leu Pro Gln Glu Leu Lys Ile Lys Phe Leu Gln Glu Ala 
225                 230                 235                 240 


Lys Ile Leu Lys Gln Tyr Asp His Pro Asn Ile Val Lys Leu Ile Gly 
                245                 250                 255     


Val Cys Thr Gln Arg Gln Pro Val Tyr Ile Ile Met Glu Leu Val Ser 
            260                 265                 270         


Gly Gly Asp Phe Leu Thr Phe Leu Arg Arg Lys Lys Asp Glu Leu Lys 
        275                 280                 285             


Leu Lys Gln Leu Val Lys Phe Ser Leu Asp Ala Ala Ala Gly Met Leu 
    290                 295                 300                 


Tyr Leu Glu Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
305                 310                 315                 320 


Cys Leu Val Gly Glu Asn Asn Val Leu Lys Ile Ser Asp Phe Gly Met 
                325                 330                 335     


Ser Arg Gln Glu Asp Gly Gly Val Tyr Ser Ser Ser Gly Leu Lys Gln 
            340                 345                 350         


Ile Pro Ile Lys Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg Tyr 
        355                 360                 365             


Ser Ser Glu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Thr 
    370                 375                 380                 


Phe Ser Leu Gly Val Cys Pro Tyr Pro Gly Met Thr Asn Gln Gln Ala 
385                 390                 395                 400 


Arg Glu Gln Val Glu Arg Gly Tyr Arg Met Ser Ala Pro Gln His Cys 
                405                 410                 415     


Pro Glu Asp Ile Ser Lys Ile Met Met Lys Cys Trp Asp Tyr Lys Pro 
            420                 425                 430         


Glu Asn Arg Pro Lys Phe Ser Glu Leu Gln Lys Glu Leu Thr Ile Ile 
        435                 440                 445             


Lys Arg Lys Leu Thr 
    450             


<210>  4
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA -fer

<400>  4
auaaguagcc aagacuugga uacgu                                             25


<210>  5
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNAferT

<400>  5
uucugaugug gaaggcucag agcug                                             25


<210>  6
<211>  1420
<212>  DNA
<213>  Homo sapiens

<400>  6
ttggtaaatt gacttccttg ggcccactgt cactatctct tagctaaatt ttgagatgga       60

gcagaaaatg aaatgtcctc attgtaagga tcagctggag tctggtttcg gctcccaatc      120

ctgtaaaaca tgtgctttaa tgttcagctc tgagccttcc acatcagaag tccacagaga      180

tcaggagaga aaggagaggc tatccaaatt tgaatctatt cgccattcaa ttgctggaat      240

aattaggtct ccaaaatctg cactgggctc ttcagcactt tctgatttga tctccatcag      300

tgagaagcct ttggcagaac aggactggta ccatggtgca attcccagaa tagaagctca      360

agaactgtta aaaaaacaag gagacttttt ggtgcgagag ggtcatggga aacctggtga      420

acatgtcctt tctgtatatt ctgatggaca gaggagacat tttatcatac aatatgttga      480

taacatgtat cgattcgagg gcactgggtt ttcaaacatt cctcaactta tagatcatca      540

ctatacaaca aaacaggtca tcactaagaa atcaggtgta gttctgctga atcctattcc      600

taaggacaag aaatggattt tcagtcatga agatgtcata ttgggagaat tactgggcaa      660

aggaaatttt ggtgaagtat ataagggcac attaaaggac aaaacttctg ttgctgttaa      720

aacatgtaaa gaagatcttc ctcaggaatt gaaaataaaa tttttacaag aagccaaaat      780

tctcaagcaa tatgatcatc ccaatattgt caaacttata ggagtttgca cacaaagaca      840

gcctgtctac atcattatgg aactggtttc aggaggtgat ttcctcacct ttctgagaag      900

gaagaaggat gaactaaaac tcaaacagtt agtgaaattt tcattggacg ctgctgctgg      960

tatgttgtat ctcgagagta aaaactgtat acacagggac cttgctgcaa gaaactgcct     1020

ggtaggtgaa aataatgttc tgaaaatcag tgactttgga atgtctcgtc aagaggatgg     1080

tggagtgtat tcatcttctg gcttaaagca gattcccatt aaatggacag caccggaagc     1140

tcttaattat gggagataca gttcagagag tgacgtgtgg agctttggca tccttctctg     1200

ggagaccttc agcttagggg tttgtccgta ccccggaatg acaaatcagc aagcaagaga     1260

gcaagtagaa agaggatacc ggatgtcagc tccccagcac tgtccagagg atatttccaa     1320

aatcatgatg aagtgttggg attataaacc tgaaaatcgc cctaagttca gtgaacttca     1380

gaaagagctc actatcatca agagaaaact cacatagtga                           1420


