                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Geles, Kenneth G.
 
<120>  ANTI-NOTCH3 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES

<130>  PC71980

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  1

Ala Pro Glu Val Ser Glu Glu Pro Arg Cys Pro Arg Ala Ala Cys Gln 
1               5                   10                  15      


Ala Lys Arg Gly Asp Gln Arg Cys Asp Arg Glu Cys Asn Ser Pro Gly 
            20                  25                  30          


Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Ser Val Gly Asp Pro Trp 
        35                  40                  45              


Arg Gln Cys Glu Ala Leu Gln Cys Trp Arg Leu Phe Asn Asn Ser Arg 
    50                  55                  60                  


Cys Asp Pro Ala Cys Ser Ser Pro Ala Cys Leu Tyr Asp Asn Phe Asp 
65                  70                  75                  80  


Cys His Ala Gly Gly Arg Glu Arg Thr Cys Asn Pro Val Tyr Glu Lys 
                85                  90                  95      


Tyr Cys Ala Asp His Phe Ala Asp Gly Arg Cys Asp Gln Gly Cys Asn 
            100                 105                 110         


Thr Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ser Glu Val Pro 
        115                 120                 125             


Ala Leu Leu Ala Arg Gly Val Leu Val Leu Thr Val Leu Leu Pro Pro 
    130                 135                 140                 


Glu Glu Leu Leu Arg Ser Ser Ala Asp Phe Leu Gln Arg Leu Ser Ala 
145                 150                 155                 160 


Ile Leu Arg Thr Ser Leu Arg Phe Arg Leu Asp Ala His Gly Gln Ala 
                165                 170                 175     


Met Val Phe Pro Tyr His Arg Pro Ser Pro Gly Ser Glu Pro Arg Ala 
            180                 185                 190         


Arg Arg Glu Leu Ala Pro Glu Val Ile Gly Ser Val Val Met Leu Glu 
        195                 200                 205             


Ile Asp Asn Arg Leu Cys Leu Gln Ser Pro Glu Asn Asp His Cys Phe 
    210                 215                 220                 


Pro Asp Ala Gln Ser Ala Ala Asp Tyr Leu Gly Ala Leu Ser Ala Val 
225                 230                 235                 240 


Glu Arg Leu Asp Phe Pro Tyr Pro Leu Arg Asp Val Arg Gly Glu Pro 
                245                 250                 255     


Leu Glu Pro Pro Glu Pro Ser Val Pro Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Gly 
        275                 280                 285             


Pro Pro His His His His His His 
    290                 295     


<210>  2
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  2
gcacccgagg tctcggagga gccgcggtgc ccgcgcgccg cctgccaggc caagcgcggg       60

gaccagcgct gcgaccgcga gtgcaacagc ccaggctgcg gctgggacgg cggcgactgc      120

tcgctgagcg tgggcgaccc ctggcggcaa tgcgaggcgc tgcagtgctg gcgcctcttc      180

aacaacagcc gctgcgaccc cgcctgcagc tcgcccgcct gcctctacga caacttcgac      240

tgccacgccg gtggccgcga gcgcacttgc aacccggtgt acgagaagta ctgcgccgac      300

cactttgccg acggccgctg cgaccagggc tgcaacacgg aggagtgcgg ctgggatggg      360

ctggattgtg ccagcgaggt gccggccctg ctggcccgcg gcgtgctggt gctcacagtg      420

ctgctgccgc cggaggagct actgcgttcc agcgccgact ttctgcagcg gctcagcgcc      480

atcctgcgca cctcgctgcg cttccgcctg gacgcgcacg gccaggccat ggtcttccct      540

taccaccggc ctagtcctgg ctccgaaccc cgggcccgtc gggagctggc ccccgaggtg      600

atcggctcgg tagtaatgct ggagattgac aaccggctct gcctgcagtc gcctgagaat      660

gatcactgct tccccgatgc ccagagcgcc gctgactacc tgggagcgtt gtcagcggtg      720

gagcgcctgg acttcccgta cccactgcgg gacgtgcggg gggagccgct ggagcctcca      780

gaacccagcg tcccgggagg gggaagcgga ggcggactga acgacatctt cgaggctcag      840

aaaatcgaat ggcacgaagg tggcccacca catcatcatc atcatcac                   888


<210>  3
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  3

Ala Pro Glu Val Pro Glu Glu Pro Arg Cys Pro Arg Ala Ala Cys Gln 
1               5                   10                  15      


Ala Lys Arg Gly Asp Gln Asn Cys Asp Arg Glu Cys Asn Thr Pro Gly 
            20                  25                  30          


Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Val Asp Asp Pro Trp 
        35                  40                  45              


Arg Gln Cys Glu Ala Leu Gln Cys Trp Arg Leu Phe Asn Asn Ser Arg 
    50                  55                  60                  


Cys Asp Pro Ala Cys Ser Ser Pro Ala Cys Leu Tyr Asp Asn Phe Asp 
65                  70                  75                  80  


Cys Tyr Ser Gly Gly Arg Asp Arg Thr Cys Asn Pro Val Tyr Glu Lys 
                85                  90                  95      


Tyr Cys Ala Asp His Phe Ala Asp Gly Arg Cys Asp Gln Gly Cys Asn 
            100                 105                 110         


Thr Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ser Glu Val Pro 
        115                 120                 125             


Ala Leu Leu Ala Arg Gly Val Leu Val Leu Thr Val Leu Leu Pro Pro 
    130                 135                 140                 


Glu Glu Leu Leu Arg Ser Ser Ala Asp Phe Leu Gln Arg Leu Ser Ala 
145                 150                 155                 160 


Ile Leu Arg Thr Ser Leu Arg Phe Arg Leu Asp Ala Arg Gly Gln Ala 
                165                 170                 175     


Met Val Phe Pro Tyr His Arg Pro Ser Pro Gly Ser Glu Ser Arg Val 
            180                 185                 190         


Arg Arg Glu Leu Gly Pro Glu Val Ile Gly Ser Val Val Met Leu Glu 
        195                 200                 205             


Ile Asp Asn Arg Leu Cys Leu Gln Ser Ala Glu Asn Asp His Cys Phe 
    210                 215                 220                 


Pro Asp Ala Gln Ser Ala Ala Asp Tyr Leu Gly Ala Leu Ser Ala Val 
225                 230                 235                 240 


Glu Arg Leu Asp Phe Pro Tyr Pro Leu Arg Asp Val Arg Gly Glu Pro 
                245                 250                 255     


Leu Glu Ala Pro Glu Gln Ser Val Pro Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Gly 
        275                 280                 285             


Pro Pro His His His His His His 
    290                 295     


<210>  4
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  4
gcccctgagg tccccgagga gccacggtgc ccgcgagcgg cttgccaggc caagcgaggg       60

gaccagaact gcgatcgtga gtgcaacacc ccaggctgtg gctgggatgg cggtgactgc      120

tcactgaacg tggacgaccc ctggaggcag tgtgaggcac tgcagtgctg gcgtctcttc      180

aacaacagcc ggtgtgaccc ggcctgcagc tctccagcct gcctctatga caactttgac      240

tgctactctg gtggccgcga ccgcacctgc aaccctgttt atgagaagta ctgcgccgac      300

cactttgcag atggccgttg tgaccagggc tgcaacactg aggaatgcgg ctgggatggg      360

ctggactgtg ccagcgaggt cccggccctt ttggcccgag gggttctggt cctcacagtt      420

cttctgcctc ctgaagagtt gctgcgctcc agtgccgact ttctgcagcg actcagcgct      480

attctgcgca cctcactgcg cttccgcttg gacgcacgtg gccaggccat ggtcttcccc      540

tatcaccggc caagccctgg ctctgaatcc cgggtccgtc gtgagctggg tcctgaggtg      600

atcggctctg tggtgatgct ggagattgac aaccggctct gtctgcagtc agctgagaat      660

gaccactgct tccctgatgc ccagagtgct gctgactacc tgggagcctt gtcagcagtg      720

gagcgacttg atttcccata cccacttcgg gatgtgcgag gagagccgct ggaggcccca      780

gagcagagcg tgccaggagg gggaagcgga ggcggactga acgacatctt cgaggctcag      840

aaaatcgaat ggcacgaagg tggcccacca catcatcatc atcatcac                   888


<210>  5
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          


Gly Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Thr Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Asn Tyr Ile Tyr Tyr Ala Glu Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Thr Arg Arg Gly Pro Phe Val Leu Asp Ala Trp Gly Gln Gly Ala Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  6
gaggtgcaac tggtggagtc tggaggaggc ttagtgcagc ctggaaggtc cctgacactc       60

tcctgtgtag cctctggatt cactttcagg gactatggaa tgacctggat tcgccaggct      120

ccagggaagg ggctgacatg ggttgcatat attagtagtg gtagcaatta catctattat      180

gcagaagcgg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga ccagtctgag gtctgaagac actgccttgt atttttgtac aagacgaggc      300

ccgtttgttt tggatgcctg gggtcaagga gcttcagtca ctgtctcctc a               351


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Ser Ile Asn Arg Tyr 
            20                  25                  30          


Leu His Trp Phe Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Gly Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Leu Gln His Asn Thr Trp Pro Asp 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  8
<211>  320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  8
gacatccaga tgacccagtc tccttcattc ctgtctgcat ctgtgggaga cagagtcact       60

atcaactgca aagcaagtca gagtattaac aggtacttac actggtttca gcagaaactt      120

ggagaagctc ccaaactcct gatatataat gcaaacggtt tgcaaacggg catcccatca      180

aggttcagtg gcagtggatc tggtactgat ttcacactta ccatcagcag cctgcagtct      240

gaagatgttg ccacatattt ctgcttgcag cataatacgt ggccggacac gtttggcgct      300

gggaccaagc tggaactgaa                                                  320


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  9

Gln Val Lys Leu Leu Gln Ser Gly Ala Ala Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asp Tyr 
            20                  25                  30          


Trp Val Thr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser Pro Asn Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Glu Ile Arg Tyr Asn Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  10
caggtcaagc tgctgcagtc tggggctgca ctggtgaagc ctggagcctc tgtgaagatg       60

tcttgcaaag cttctggtta tgcattcact gactactggg tgacctgggt gaagcagagt      120

catggaaaga gccttgagtg gattggggaa atttctccta acagtggtgg tactaacttc      180

aatgaaaagt tcaagggcaa ggccacattg actgtagaca aatccaccag cacagcctat      240

atggagctca gcagattgac atctgaggac tctgcaatct attactgtac aagaggggaa      300

atccgttaca attggtttgc ttactggggc caaggcactc tggtcactgt ctcctca         357


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Asn Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Leu Tyr Asn Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  12
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  12
aacattgtga tgacccagtc tcccaaatcc atgtccatat cagtaggaga cagggtcacc       60

atgaactgca aggccagtca gaatgtgggt aataatatag cctggtatca acagaaacca      120

gggcagtctc ctaaactgtt gatctactat gcatctaacc ggtacactgg ggtccctgat      180

cgcttcacag gcggtggata tgggacagat ttcactctca ccatcaatag tatgcaagct      240

gaagatgcag ccttttatta ctgtcagcgt ctttacaatt ctccattcac gttcggctca      300

gggacgaagt tggaaataaa g                                                321


<210>  13
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Asn Tyr Ile Tyr Tyr Ala Glu Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Pro Phe Val Leu Asp Ala Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  14
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagg gactatggaa tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggcctat attagtagtg gtagcaatta catctattat      180

gcagaagcgg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacgaggc      300

ccgtttgttt tggatgcctg gggccaggga accctggtca ccgtctcctc a               351


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  15

Asp Tyr Gly Met Thr 
1               5   


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  16

Gly Phe Thr Phe Arg Asp Tyr 
1               5           


<210>  17
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  17
gactatggaa tgacc                                                        15


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  18
ggattcactt tcagggacta t                                                 21


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  19

Tyr Ile Ser Ser Gly Ser Asn Tyr Ile Tyr Tyr Ala Glu Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  20

Ser Ser Gly Ser Asn Tyr 
1               5       


<210>  21
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  21
tatattagta gtggtagcaa ttacatctat tatgcagaag cggtgaaggg c                51


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  22
agtagtggta gcaattac                                                     18


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  23

Arg Gly Pro Phe Val Leu Asp Ala 
1               5               


<210>  24
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  24
cgaggcccgt ttgttttgga tgcc                                              24


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile Asn Arg Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Gly Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Trp Pro Asp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  26
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  26
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aagcaagtca gagtattaac aggtacttac actggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctataat gcaaacggtt tgcaaacggg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtttgcag cataatacgt ggccggacac gtttggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  27

Lys Ala Ser Gln Ser Ile Asn Arg Tyr Leu His 
1               5                   10      


<210>  28
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  28
aaagcaagtc agagtattaa caggtactta cac                                    33


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  29

Asn Ala Asn Gly Leu Gln Thr 
1               5           


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  30
aatgcaaacg gtttgcaaac g                                                 21


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  31

Leu Gln His Asn Thr Trp Pro Asp Thr 
1               5                   


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  32
ttgcagcata atacgtggcc ggacacgttt                                        30


<210>  33
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Asn Tyr Ile Tyr Tyr Ala Glu Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Pro Phe Val Leu Asp Ala Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  34
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  34
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagg gactatggaa tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggcctat attagtagtg gtagcaatta catctattat      180

gcagaagcgg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacgaggc      300

ccgtttgttt tggatgcctg gggccaggga accctggtca ccgtctcctc agcgtcgacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ccccgggt                                                   1338


<210>  35
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile Asn Arg Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Gly Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Trp Pro Asp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  36
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  36
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aagcaagtca gagtattaac aggtacttac actggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctataat gcaaacggtt tgcaaacggg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtttgcag cataatacgt ggccggacac gtttggcgga      300

gggaccaagg tggagatcaa acggaccgtg gccgctcctt ccgtgttcat cttcccccct      360

tccgacgagc agctgaagtc tggcaccgcc tctgtggtgt gtctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgctc tgcagtccgg caactcccag      480

gagtctgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc taccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      600

ctgtcctctc ctgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  37
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ala Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Ser Pro Asn Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Ile Arg Tyr Asn Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  38
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggtta tgcattcact gactactgga tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccgaa atttctccta acagtggtgg tactaacttc      180

aatgaaaagt tcaagggccg attcaccatc tccgttgaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggggaa      300

atccgttaca attggtttgc ttactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  39

Asp Tyr Trp Met Thr 
1               5   


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  40

Gly Tyr Ala Phe Thr Asp Tyr 
1               5           


<210>  41
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  41
gactactgga tgacc                                                        15


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  42
ggttatgcat tcactgacta c                                                 21


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  43

Glu Ile Ser Pro Asn Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  44

Ser Pro Asn Ser Gly Gly 
1               5       


<210>  45
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  45
gaaatttctc ctaacagtgg tggtactaac ttcaatgaaa agttcaaggg c                51


<210>  46
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  46
tctcctaaca gtggtggt                                                     18


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  47

Gly Glu Ile Arg Tyr Asn Trp Phe Ala Tyr 
1               5                   10  


<210>  48
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  48
ggggaaatcc gttacaattg gtttgcttac                                        30


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Asn Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Leu Tyr Asn Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  50
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  50
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggccagtca gaatgtgggt aataatatag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattat gcatctaacc ggtacactgg ggtcccatca      180

aggttcagtg gcagtggata tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcgt ctttacaatt ctccattcac gttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  51

Lys Ala Ser Gln Asn Val Gly Asn Asn Ile Ala 
1               5                   10      


<210>  52
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  52
aaggccagtc agaatgtggg taataatata gcc                                    33


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  53

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  54
tatgcatcta accggtacac t                                                 21


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  55

Gln Arg Leu Tyr Asn Ser Pro Phe Thr 
1               5                   


<210>  56
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  56
cagcgtcttt acaattctcc attcacgttc                                        30


<210>  57
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ala Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Ser Pro Asn Ser Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Val Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Ile Arg Tyr Asn Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  58
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  58
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggtta tgcattcact gactactgga tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccgaa atttctccta acagtggtgg tactaacttc      180

aatgaaaagt tcaagggccg attcaccatc tccgttgaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggggaa      300

atccgttaca attggtttgc ttactggggc cagggaaccc tggtcaccgt ctcctcagcg      360

tcgaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtcccc gggt                                            1344


<210>  59
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Asn Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Leu Tyr Asn Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  60
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  60
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggccagtca gaatgtgggt aataatatag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattat gcatctaacc ggtacactgg ggtcccatca      180

aggttcagtg gcagtggata tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcgt ctttacaatt ctccattcac gttcggcgga      300

gggaccaagg tggagatcaa acggaccgtg gccgctcctt ccgtgttcat cttcccccct      360

tccgacgagc agctgaagtc tggcaccgcc tctgtggtgt gtctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgctc tgcagtccgg caactcccag      480

gagtctgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc taccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      600

ctgtcctctc ctgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  61
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Asn Tyr Ile Tyr Tyr Ala Glu Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Pro Phe Val Leu Asp Ala Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Cys Ser Pro Gly 
        435                 440                 445     


<210>  62
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  62
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagg gactatggaa tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggcctat attagtagtg gtagcaatta catctattat      180

gcagaagcgg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacgaggc      300

ccgtttgttt tggatgcctg gggccaggga accctggtca ccgtctcctc agcgtcgacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctcctgct ccccgggt                                                   1338


<210>  63
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile Asn Arg Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Gly Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Trp Pro Asp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Cys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  64
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  64
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aagcaagtca gagtattaac aggtacttac actggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctataat gcaaacggtt tgcaaacggg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtttgcag cataatacgt ggccggacac gtttggcgga      300

gggaccaagg tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagctgcg cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  65
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Asn Tyr Ile Tyr Tyr Ala Glu Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Pro Phe Val Leu Asp Ala Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Cys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Cys Ser Pro Gly 
        435                 440                 445     


<210>  66
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  66
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagg gactatggaa tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggcctat attagtagtg gtagcaatta catctattat      180

gcagaagcgg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacgaggc      300

ccgtttgttt tggatgcctg gggccaggga accctggtca ccgtctcctc agcgtcgacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tactgcacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctcctgct ccccgggt                                                   1338


<210>  67
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  68
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


