                         SEQUENCE LISTING

<110>  Roche Diagnostics GmbH, Mannheim (DE)
       F. Hoffmann-La Roche AG, Basel (CH)
 
<120>  Nucleic acids encoding chimeric polypeptides for library 
       screening

<130>  31322 WO

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  optional invariant amino acid sequence within X

<400>  1

Gly Ala Gly Ser 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  optional invariant amino acid sequence within X

<400>  2

Gly Ser Ser Gly 
1               


<210>  3
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  optional invariant amino acid sequence within X

<400>  3

Gly Ser Ser 
1           


<210>  4
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  specific embodiment of formula I


<220>
<221>  MISC_FEATURE
<223>  In line with the description of formula I, Xaa represents an 
       amino acid sequence comprising a variable sequence to be 
       displayed by the chimeric polypeptide

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Met Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr Leu Gln 
1               5                   10                  15      


Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu His Gly 
            20                  25                  30          


His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly Arg Glu 
        35                  40                  45              


Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala Tyr Xaa 
    50                  55                  60                  


Gly Lys Asp Leu Asp Phe Gln Val Glu Val Val Lys Val Arg Glu Ala 
65                  70                  75                  80  


Thr Pro Glu Glu Leu Leu His Gly His Ala 
                85                  90  


<210>  5
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  In line with the description of formula I, Xaa represents an 
       amino acid sequence comprising a variable sequence to be 
       displayed by the Thermus thermophilus SlyD chimeric polypeptide


<220>
<221>  MISC_FEATURE
<223>  In line with the description of formula I, Xaa represents an 
       amino acid sequence comprising a variable sequence to be 
       displayed by the chimeric polypeptide

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Met Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr Leu Gln 
1               5                   10                  15      


Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu His Gly 
            20                  25                  30          


His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly Arg Glu 
        35                  40                  45              


Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala Tyr Xaa 
    50                  55                  60                  


Gly Lys Asp Leu Asp Phe Gln Val Glu Val Val Lys Val Arg Glu Ala 
65                  70                  75                  80  


Thr Pro Glu Glu Leu Leu His Gly His Ala Gly Ala Gly Ser Gly Ala 
                85                  90                  95      


Gly Ala Gly Ser Gly Ala Gly Ala Gly Ser Pro Ala Ala Val Pro Ala 
            100                 105                 110         


Ala Val Pro Ala Ala Val Gly Glu Gly Glu Gly Glu Phe Ser Thr Pro 
        115                 120                 125             


Val Trp Ile Ser Gln Ala Gln Gly Ile Arg Ala Gly Pro Gln Arg Leu 
    130                 135                 140                 


Ser Asn Pro Gln Pro Met Arg Gly 
145                 150         


<210>  6
<211>  165
<212>  PRT
<213>  Escherichia coli

<400>  6

Met Lys Val Ala Lys Asp Leu Val Val Ser Leu Ala Tyr Gln Val Arg 
1               5                   10                  15      


Thr Glu Asp Gly Val Leu Val Asp Glu Ser Pro Val Ser Ala Pro Leu 
            20                  25                  30          


Asp Tyr Leu His Gly His Gly Ser Leu Ile Ser Gly Leu Glu Thr Ala 
        35                  40                  45              


Leu Glu Gly His Glu Val Gly Asp Lys Phe Asp Val Ala Val Gly Ala 
    50                  55                  60                  


Asn Asp Ala Tyr Gly Gln Tyr Asp Glu Asn Leu Val Gln Arg Val Pro 
65                  70                  75                  80  


Lys Asp Val Phe Met Gly Val Asp Glu Leu Gln Val Gly Met Arg Phe 
                85                  90                  95      


Leu Ala Glu Thr Asp Gln Gly Pro Val Pro Val Glu Ile Thr Ala Val 
            100                 105                 110         


Glu Asp Asp His Val Val Val Asp Gly Asn His Met Leu Ala Gly Gln 
        115                 120                 125             


Asn Leu Lys Phe Asn Val Glu Val Val Ala Ile Arg Glu Ala Thr Glu 
    130                 135                 140                 


Glu Glu Leu Ala His Gly His Val His Gly Ala His Asp His His His 
145                 150                 155                 160 


Asp His Asp His Asp 
                165 


<210>  7
<211>  149
<212>  PRT
<213>  Thermus thermophilus

<400>  7

Met Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr Leu Gln 
1               5                   10                  15      


Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu His Gly 
            20                  25                  30          


His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly Arg Glu 
        35                  40                  45              


Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala Tyr Gly 
    50                  55                  60                  


Pro His Asp Pro Glu Gly Val Gln Val Val Pro Leu Ser Ala Phe Pro 
65                  70                  75                  80  


Glu Asp Ala Glu Val Val Pro Gly Ala Gln Phe Tyr Ala Gln Asp Met 
                85                  90                  95      


Glu Gly Asn Pro Met Pro Leu Thr Val Val Ala Val Glu Gly Glu Glu 
            100                 105                 110         


Val Thr Val Asp Phe Asn His Pro Leu Ala Gly Lys Asp Leu Asp Phe 
        115                 120                 125             


Gln Val Glu Val Val Lys Val Arg Glu Ala Thr Pro Glu Glu Leu Leu 
    130                 135                 140                 


His Gly His Ala His 
145                 


<210>  8
<211>  156
<212>  PRT
<213>  Thermococcus gammatolerans

<400>  8

Met Lys Val Glu Arg Gly Asp Phe Val Leu Phe Asn Tyr Val Gly Arg 
1               5                   10                  15      


Tyr Glu Asn Gly Glu Val Phe Asp Thr Ser Tyr Glu Ser Val Ala Arg 
            20                  25                  30          


Glu Gln Gly Ile Phe Val Glu Glu Arg Glu Tyr Ser Pro Ile Gly Val 
        35                  40                  45              


Thr Val Gly Ala Gly Glu Ile Ile Pro Gly Ile Glu Glu Ala Leu Leu 
    50                  55                  60                  


Gly Met Glu Leu Gly Glu Lys Lys Glu Val Val Val Pro Pro Glu Lys 
65                  70                  75                  80  


Gly Tyr Gly Met Pro Arg Glu Asp Leu Ile Val Pro Val Pro Ile Glu 
                85                  90                  95      


Gln Phe Thr Ser Ala Gly Leu Glu Pro Val Glu Gly Met Tyr Val Met 
            100                 105                 110         


Thr Asp Ala Gly Ile Ala Lys Ile Leu Lys Val Glu Glu Lys Thr Val 
        115                 120                 125             


Arg Leu Asp Phe Asn His Pro Leu Ala Gly Lys Thr Ala Ile Phe Glu 
    130                 135                 140                 


Ile Glu Val Val Glu Ile Lys Lys Ala Gly Glu Ala 
145                 150                 155     


<210>  9
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  10
<211>  129
<212>  PRT
<213>  Arabidopsis thaliana

<400>  10

Glu Thr Thr Ser Cys Glu Phe Ser Val Ser Pro Ser Gly Leu Ala Phe 
1               5                   10                  15      


Cys Asp Lys Val Val Gly Tyr Gly Pro Glu Ala Val Lys Gly Gln Leu 
            20                  25                  30          


Ile Lys Ala His Tyr Val Gly Lys Leu Glu Asn Gly Lys Val Phe Asp 
        35                  40                  45              


Ser Ser Tyr Asn Arg Gly Lys Pro Leu Thr Phe Arg Ile Gly Val Gly 
    50                  55                  60                  


Glu Val Ile Lys Gly Trp Asp Gln Gly Ile Leu Gly Ser Asp Gly Ile 
65                  70                  75                  80  


Pro Pro Met Leu Thr Gly Gly Lys Arg Thr Leu Arg Ile Pro Pro Glu 
                85                  90                  95      


Leu Ala Tyr Gly Asp Arg Gly Ala Gly Cys Lys Gly Gly Ser Cys Leu 
            100                 105                 110         


Ile Pro Pro Ala Ser Val Leu Leu Phe Asp Ile Glu Tyr Ile Gly Lys 
        115                 120                 125             


Ala 
    


<210>  11
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  specific embodiment of formula I


<220>
<221>  MISC_FEATURE
<223>  In line with the description of formula I, Xaa represents an 
       amino acid sequence comprising a variable sequence to be 
       displayed by the chimeric polypeptide

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Met Arg Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Ala Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Xaa Thr Leu Val Phe Asp Val Glu Leu Leu 
                85                  90                  95      


Lys Leu Glu 
            


<210>  12
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  specific embodiment of formula I


<220>
<221>  MISC_FEATURE
<223>  In line with the description of formula I, Xaa represents an 
       amino acid sequence comprising a variable sequence to be 
       displayed by the chimeric polypeptide

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Met Arg Ser Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr 
1               5                   10                  15      


Leu Gln Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu 
            20                  25                  30          


His Gly His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly 
        35                  40                  45              


Arg Glu Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala 
    50                  55                  60                  


Tyr Xaa Gly Lys Asp Leu Asp Phe Gln Val Glu Val Val Lys Val Arg 
65                  70                  75                  80  


Glu Ala Thr Pro Glu Glu Leu Leu His Gly His Ala His 
                85                  90              


<210>  13
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  specific embodiment of formula I


<220>
<221>  MISC_FEATURE
<223>  In line with the description of formula I, Xaa represents an 
       amino acid sequence comprising a variable sequence to be 
       displayed by the chimeric polypeptide

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Met Lys Val Glu Arg Gly Asp Phe Val Leu Phe Asn Tyr Val Gly Arg 
1               5                   10                  15      


Tyr Glu Asn Gly Glu Val Phe Asp Thr Ser Tyr Glu Ser Val Ala Arg 
            20                  25                  30          


Glu Gln Gly Ile Phe Val Glu Glu Arg Glu Tyr Ser Pro Ile Gly Val 
        35                  40                  45              


Thr Val Gly Ala Gly Glu Ile Ile Pro Gly Ile Glu Glu Ala Leu Leu 
    50                  55                  60                  


Gly Met Glu Leu Gly Glu Lys Lys Glu Val Val Val Pro Pro Glu Lys 
65                  70                  75                  80  


Gly Tyr Gly Met Pro Xaa Ala Gly Lys Thr Ala Ile Phe Glu Ile Glu 
                85                  90                  95      


Val Val Glu Ile Lys Lys Ala Gly Glu Ala 
            100                 105     


<210>  14
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  specific embodiment of formula I


<220>
<221>  misc_feature
<223>  In line with the description of formula I, Xaa represents an 
       amino acid sequence comprising a variable sequence to be 
       displayed by the chimeric polypeptide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Gly Asp Arg Gly Ala Gly Cys Gly Ser Xaa Gly Ser Ser Cys Leu Ile 
1               5                   10                  15      


Pro Pro Ala Ser Val Leu Asp Phe Gln Val Glu Val Val Lys Val Arg 
            20                  25                  30          


Glu Ala Thr Pro Glu Glu Leu Leu His Gly His Ala His 
        35                  40                  45  


<210>  15
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  specific embodiment of formula I


<220>
<221>  MISC_FEATURE
<223>  In line with the description of formula I, Xaa represents an 
       amino acid sequence comprising a variable sequence to be 
       displayed by the chimeric polypeptide

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Glu Thr Thr Ser Cys Glu Phe Ser Val Ser Pro Ser Gly Leu Ala Phe 
1               5                   10                  15      


Cys Asp Lys Val Val Gly Tyr Gly Pro Glu Ala Val Lys Gly Gln Leu 
            20                  25                  30          


Ile Lys Ala His Tyr Val Gly Lys Leu Glu Asn Gly Lys Val Phe Asp 
        35                  40                  45              


Ser Ser Tyr Asn Arg Gly Lys Pro Leu Thr Phe Arg Ile Gly Val Gly 
    50                  55                  60                  


Glu Val Ile Lys Gly Trp Asp Gln Gly Ile Leu Gly Ser Asp Gly Ile 
65                  70                  75                  80  


Pro Pro Met Leu Thr Gly Gly Lys Arg Thr Leu Arg Ile Pro Pro Glu 
                85                  90                  95      


Leu Ala Tyr Gly Asp Arg Gly Ala Gly Cys Gly Ser Xaa Gly Ser Ser 
            100                 105                 110         


Cys Leu Ile Pro Pro Ala Ser Val Leu Leu Phe Asp Ile Glu Tyr Ile 
        115                 120                 125             


Gly Lys Ala 
    130     


<210>  16
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  specific embodiment of formula I


<220>
<221>  MISC_FEATURE
<223>  In line with the description of formula I, Xaa represents an 
       amino acid sequence comprising a variable sequence to be 
       displayed by the chimeric polypeptide

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Met Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr Leu Gln 
1               5                   10                  15      


Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu His Gly 
            20                  25                  30          


His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly Arg Glu 
        35                  40                  45              


Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala Tyr Xaa 
    50                  55                  60                  


Gly Lys Asp Leu Asp Phe Gln Val Glu Val Val Lys Val Arg Glu Ala 
65                  70                  75                  80  


Thr Pro Glu Glu Leu Leu His Gly His Ala 
                85                  90  


<210>  17
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  specific embodiment of formula I


<220>
<221>  MISC_FEATURE
<223>  In line with the description of formula I, Xaa represents an 
       amino acid sequence comprising a variable sequence to be 
       displayed by the chimeric polypeptide

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Met Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr Leu Gln 
1               5                   10                  15      


Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu His Gly 
            20                  25                  30          


His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly Arg Glu 
        35                  40                  45              


Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala Tyr Xaa 
    50                  55                  60                  


Gly Lys Asp Leu Asp Phe Gln Val Glu Val Val Lys Val Arg Glu Ala 
65                  70                  75                  80  


Thr Pro Glu Glu Leu Leu His Gly His Ala Gly Ala Gly Ser Gly Ala 
                85                  90                  95      


Gly Ala Gly Ser Gly Ala Gly Ala Gly Ser Pro Ala Ala Val Pro Ala 
            100                 105                 110         


Ala Val Pro Ala Ala Val Gly Glu Gly Glu Gly Glu Phe Ser Thr Pro 
        115                 120                 125             


Val Trp Ile Ser Gln Ala Gln Gly Ile Arg Ala Gly Pro Gln Arg Leu 
    130                 135                 140                 


Ser Asn Pro Gln Pro Met Arg Gly 
145                 150         


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
cgacagtgtg gcgcaggatc c                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
gggagctcgc aggagacgta g                                                 21


<210>  20
<211>  719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA construct

<400>  20
ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg gcgccggtga tgccggccac       60

gatgcgtccg gcgtagagga tcgtgatctc gatcccgcga aattaatacg actcactata      120

gggagaccac aacggtttcc ctctagaaat aattttgttt aactttaaga aggagatata      180

catatgaaag tgggccagga taaagttgtc accattcgct ataccctgca ggttgaaggt      240

gaagtgctgg atcagggcga actcagctat ttacatggtc accgcaacct gattccgggc      300

ctggaggaag cgctggaagg tcgcgaggaa ggcgaagcat ttcaggcgca tgtgccggca      360

gagaaagcgt atggcgccgg atccccgcag cctctggtgt ataacaaatt aacctttcag      420

ctggaaccga accctcatac caaagggagc tccggcaaag atttagattt tcaggtggaa      480

gtggttaaag tgcgcgaagc aaccccggag gaactgttac atggccacgc gggcgctggc      540

tctggagctg gtgcaggctc tggtgctggc gcaggttctc cagcagcggt gccggcagca      600

gttcctgctg cggtgggcga aggcgaggga gagttcagta cgccagtttg gatctcgcag      660

gcacagggca tccgtgctgg tcctcagagg ctttccaacc cccagcctat gcgggggtt       719


<210>  21
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence encoded by DNA construct

<400>  21

Met Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr Leu Gln 
1               5                   10                  15      


Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu His Gly 
            20                  25                  30          


His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly Arg Glu 
        35                  40                  45              


Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala Tyr Gly 
    50                  55                  60                  


Ala Gly Ser Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
65                  70                  75                  80  


Glu Pro Asn Pro His Thr Lys Gly Ser Ser Gly Lys Asp Leu Asp Phe 
                85                  90                  95      


Gln Val Glu Val Val Lys Val Arg Glu Ala Thr Pro Glu Glu Leu Leu 
            100                 105                 110         


His Gly His Ala Gly Ala Gly Ser Gly Ala Gly Ala Gly Ser Gly Ala 
        115                 120                 125             


Gly Ala Gly Ser Pro Ala Ala Val Pro Ala Ala Val Pro Ala Ala Val 
    130                 135                 140                 


Gly Glu Gly Glu Gly Glu Phe Ser Thr Pro Val Trp Ile Ser Gln Ala 
145                 150                 155                 160 


Gln Gly Ile Arg Ala Gly Pro Gln Arg Leu Ser Asn Pro Gln Pro Met 
                165                 170                 175     


Arg Gly 
        


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of beta-hairpin

<400>  22

Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu Glu Pro Asn 
1               5                   10                  15      


Pro His Thr Lys 
            20  


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
aacccccgca taggctgggg                                                   20


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
ggtgatgtcg gcgatatagg cgc                                               23


<210>  25
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
cgaaattaat acgactcact atagggagac cacaacggtt tccc                        44


<210>  26
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  26
gggagaccac aacggtttcc ctctagaaat aattttgttt aactttaaga aggagatata       60

catatg                                                                  66


<210>  27
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
aacccccgca taggctgggg gttggaaagc ctctgaggac cagcacg                     47


<210>  28
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28
ggaaagcctc tgaggaccag cacggatgcc ctgtgc                                 36


<210>  29
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
cgtcacacga cagtgtggcg caggatcc                                          28


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
cgtcacaagc tacgtctcct gcgagctccc                                        30


<210>  31
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variable DNA sequence


<220>
<221>  misc_feature
<222>  (22)..(60)
<223>  n is a, c, g, or t

<400>  31
cgacagtgtg gcgcaggatc cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

gggagctcgc aggagacgta gc                                                82


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
ggtgatgtcg gcgatatagg cgc                                               23


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
ccccagccta tgcgggggtt                                                   20


<210>  34
<211>  698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Thermus thermophilus SlyD-FKBP DNA construct


<220>
<221>  misc_feature
<222>  (385)..(423)
<223>  n is a, c, g, or t

<400>  34
ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg gcgccggtga tgccggccac       60

gatgcgtccg gcgtagagga tcgtgatctc gatcccgcga aattaatacg actcactata      120

gggagaccac aacggtttcc ctctagaaat aattttgttt aactttaaga aggagatata      180

catatgaaag tgggccagga taaagttgtc accattcgct ataccctgca ggttgaaggt      240

gaagtgctgg atcagggcga actcagctat ttacatggtc accgcaacct gattccgggc      300

ctggaggaag cgctggaagg tcgcgaggaa ggcgaagcat ttcaggcgca tgtgccggca      360

gagaaagcgt atggcgccgg atccnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      420

nnngggagct ccggcaaaga tttagatttt caggtggaag tggttaaagt gcgcgaagca      480

accccggagg aactgttaca tggccacgcg ggcgctggct ctggagctgg tgcaggctct      540

ggtgctggcg caggttctcc agcagcggtg ccggcagcag ttcctgctgc ggtgggcgaa      600

ggcgagggag agttcagtac gccagtttgg atctcgcagg cacagggcat ccgtgctggt      660

cctcagaggc tttccaaccc ccagcctatg cgggggtt                              698


<210>  35
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  specific embodiment of formula I


<220>
<221>  MISC_FEATURE
<223>  In line with the description of formula I, Xaa represent a 
       variable amino acid sequence to be displayed by the chimeric 
       polypeptide

<220>
<221>  misc_feature
<222>  (70)..(82)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Met Arg Ser Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr 
1               5                   10                  15      


Leu Gln Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu 
            20                  25                  30          


His Gly His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly 
        35                  40                  45              


Arg Glu Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala 
    50                  55                  60                  


Tyr Gly Ala Gly Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Gly Ser Ser Gly Lys Asp Leu Asp Phe Gln Val Glu Val Val 
                85                  90                  95      


Lys Val Arg Glu Ala Thr Pro Glu Glu Leu Leu His Gly His Gly Gly 
            100                 105                 110         


Ala Ala Ala Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
        115                 120                 125             


His Glu Gly Ser Arg Lys His His His His His His His His 
    130                 135                 140         


<210>  36
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence

<400>  36

Met Arg Ser Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr 
1               5                   10                  15      


Leu Gln Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu 
            20                  25                  30          


His Gly His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly 
        35                  40                  45              


Arg Glu Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala 
    50                  55                  60                  


Tyr Gly Ala Gly Ser Trp Lys Pro His Phe Asn Leu His Leu Leu Tyr 
65                  70                  75                  80  


Leu Ile Gly Ser Ser Gly Lys Asp Leu Asp Phe Gln Val Glu Val Val 
                85                  90                  95      


Lys Val Arg Glu Ala Thr Pro Glu Glu Leu Leu His Gly His Ala His 
            100                 105                 110         


Gly Gly Ala Ala Ala Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile 
        115                 120                 125             


Glu Trp His Glu Gly Ser Arg Lys His His His His His His His His 
    130                 135                 140                 


<210>  37
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence

<400>  37

Gly Ala Gly Ser Trp Lys Pro His Phe Asn Leu His Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ser Ser Gly 
            20      


<210>  38
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence

<400>  38

Gly Ala Gly Ser Trp Lys Pro His Phe Asn Leu His Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ser Ser Gly 
            20      


<210>  39
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence

<400>  39

Gly Ala Gly Ser Thr Tyr Tyr Lys Ile His Val Leu Trp Leu Ile Tyr 
1               5                   10                  15      


Val Gly Ser Ser Gly 
            20      


<210>  40
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence

<400>  40

Gly Ala Gly Ser Trp Lys Pro His Phe Asn Leu His Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ser Ser Gly 
            20      


<210>  41
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence

<400>  41

Gly Ala Gly Ser Tyr Tyr Val Leu Ile Thr Asp Asn Leu Val Tyr Phe 
1               5                   10                  15      


Gly Gly Ser Ser Gly 
            20      


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence

<400>  42

Gly Gly Gly Ser 
1               


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence

<400>  43

Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric polypeptide

<400>  44

Met Arg Gly Ser Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr 
1               5                   10                  15      


Thr Leu Gln Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr 
            20                  25                  30          


Leu His Gly His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu 
        35                  40                  45              


Gly Arg Glu Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys 
    50                  55                  60                  


Ala Tyr Gly Pro His Gly Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 
65                  70                  75                  80  


Arg Arg Ala Pro Gln Thr Gly Gly Ala Gly Lys Asp Leu Asp Phe Gln 
                85                  90                  95      


Val Glu Val Val Lys Val Arg Glu Ala Thr Pro Glu Glu Leu Leu His 
            100                 105                 110         


Gly His Ala His Gly Gly Gly Ser Arg Lys His His His His His His 
        115                 120                 125             


His His 
    130 


<210>  45
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric polypeptide

<400>  45

Met Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr Leu Gln 
1               5                   10                  15      


Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu His Gly 
            20                  25                  30          


His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly Arg Glu 
        35                  40                  45              


Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala Tyr Gly 
    50                  55                  60                  


Pro His Asp Pro Glu Gly Val Gln Val Val Pro Leu Ser Ala Phe Pro 
65                  70                  75                  80  


Glu Asp Ala Glu Val Val Pro Gly Ala Gln Phe Tyr Ala Gln Asp Met 
                85                  90                  95      


Glu Gly Asn Pro Met Pro Leu Thr Val Val Ala Val Glu Gly Glu Glu 
            100                 105                 110         


Val Thr Val Asp Phe Asn His Pro Leu Ala Gly Lys Asp Leu Asp Phe 
        115                 120                 125             


Gln Val Glu Val Val Lys Val Arg Glu Ala Thr Pro Glu Glu Leu Leu 
    130                 135                 140                 


His Gly His Ala His Gly Gly Gly Ser Arg Lys His His His His His 
145                 150                 155                 160 


His 
    


<210>  46
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric polypeptide

<400>  46

Met Arg Gly Ser Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr 
1               5                   10                  15      


Thr Leu Gln Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr 
            20                  25                  30          


Leu His Gly His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu 
        35                  40                  45              


Gly Arg Glu Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys 
    50                  55                  60                  


Ala Tyr Gly Pro His Gly Ala Gly Ser Gly Ser Ser Gly Ala Gly Lys 
65                  70                  75                  80  


Asp Leu Asp Phe Gln Val Glu Val Val Lys Val Arg Glu Ala Thr Pro 
                85                  90                  95      


Glu Glu Leu Leu His Gly His Ala His Gly Gly Gly Ser Arg Lys His 
            100                 105                 110         


His His His His His His His 
        115                 


<210>  47
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric polypeptide

<400>  47

Met Lys Val Glu Arg Gly Asp Phe Val Leu Phe Asn Tyr Val Gly Arg 
1               5                   10                  15      


Tyr Glu Asn Gly Glu Val Phe Asp Thr Ser Tyr Glu Ser Val Ala Arg 
            20                  25                  30          


Glu Gln Gly Ile Phe Val Glu Glu Arg Glu Tyr Ser Pro Ile Gly Val 
        35                  40                  45              


Thr Val Gly Ala Gly Glu Ile Ile Pro Gly Ile Glu Glu Ala Leu Leu 
    50                  55                  60                  


Gly Met Glu Leu Gly Glu Lys Lys Glu Val Val Val Pro Pro Glu Lys 
65                  70                  75                  80  


Gly Tyr Gly Met Pro Arg Glu Asp Leu Ile Val Pro Val Pro Ile Glu 
                85                  90                  95      


Gln Phe Thr Ser Ala Gly Leu Glu Pro Val Glu Gly Met Tyr Val Met 
            100                 105                 110         


Thr Asp Ala Gly Ile Ala Lys Ile Leu Lys Val Glu Glu Lys Thr Val 
        115                 120                 125             


Arg Leu Asp Phe Asn His Pro Leu Ala Gly Lys Thr Ala Ile Phe Glu 
    130                 135                 140                 


Ile Glu Val Val Glu Ile Lys Lys Ala Gly Glu Ala Gly Gly Gly Ser 
145                 150                 155                 160 


Arg Lys His His His His His His 
                165             


<210>  48
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric polypeptide

<400>  48

Met Lys Val Glu Arg Gly Asp Phe Val Leu Phe Asn Tyr Val Gly Arg 
1               5                   10                  15      


Tyr Glu Asn Gly Glu Val Phe Asp Thr Ser Tyr Glu Ser Val Ala Arg 
            20                  25                  30          


Glu Gln Gly Ile Phe Val Glu Glu Arg Glu Tyr Ser Pro Ile Gly Val 
        35                  40                  45              


Thr Val Gly Ala Gly Glu Ile Ile Pro Gly Ile Glu Glu Ala Leu Leu 
    50                  55                  60                  


Gly Met Glu Leu Gly Glu Lys Lys Glu Val Val Val Pro Pro Glu Lys 
65                  70                  75                  80  


Gly Tyr Gly Met Pro Gly Ser Arg Val Ser Arg Arg Ser Arg Gly Gly 
                85                  90                  95      


Ala Gly Lys Thr Ala Ile Phe Glu Ile Glu Val Val Glu Ile Lys Lys 
            100                 105                 110         


Ala Gly Glu Ala Gly Gly Gly Ser Arg Lys His His His His His His 
        115                 120                 125             


<210>  49
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric polypeptide

<400>  49

Met Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr Thr Leu Gln 
1               5                   10                  15      


Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr Leu His Gly 
            20                  25                  30          


His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu Gly Arg Glu 
        35                  40                  45              


Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys Ala Tyr Gly 
    50                  55                  60                  


Pro His Gly Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala 
65                  70                  75                  80  


Pro Gln Thr Gly Gly Ala Gly Lys Asp Leu Asp Phe Gln Val Glu Val 
                85                  90                  95      


Val Lys Val Arg Glu Ala Thr Pro Glu Glu Leu Leu His Gly His Ala 
            100                 105                 110         


His Pro Ser Gly His His His His His His 
        115                 120         


<210>  50
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric polypeptide

<400>  50

Met Arg Gly Ser Lys Val Gly Gln Asp Lys Val Val Thr Ile Arg Tyr 
1               5                   10                  15      


Thr Leu Gln Val Glu Gly Glu Val Leu Asp Gln Gly Glu Leu Ser Tyr 
            20                  25                  30          


Leu His Gly His Arg Asn Leu Ile Pro Gly Leu Glu Glu Ala Leu Glu 
        35                  40                  45              


Gly Arg Glu Glu Gly Glu Ala Phe Gln Ala His Val Pro Ala Glu Lys 
    50                  55                  60                  


Ala Tyr Gly Pro His Asp Pro Glu Gly Val Gln Val Val Pro Leu Ser 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Ala Glu Val Val Pro Gly Ala Gln Phe Tyr Ala 
                85                  90                  95      


Gln Asp Met Glu Gly Asn Pro Met Pro Leu Thr Val Val Ala Val Glu 
            100                 105                 110         


Gly Glu Glu Val Thr Val Asp Phe Asn His Pro Leu Ala Gly Lys Asp 
        115                 120                 125             


Leu Asp Phe Gln Val Glu Val Val Lys Val Arg Glu Ala Thr Pro Glu 
    130                 135                 140                 


Glu Leu Leu His Gly His Ala His Gly Gly Gly Ser Arg Lys His His 
145                 150                 155                 160 


His His His His His His 
                165     


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  specific embodiment of Histidine tag

<400>  51

Gly Ser Arg Lys His His His His His His His His 
1               5                   10          


