                         SEQUENCE LISTING

<110>  VAN VLASSELAER, PETER
       Parry, Graham
       Stagliano, Nancy E
       Panicker, Sandip
 
<120>  ANTI-COMPLEMENT C1S ANTIBODIES AND USES THEREOF

<130>  TNRX-801WO

<150>  US 61/721,916
<151>  2012-11-02

<150>  US 61/754,123
<151>  2013-01-18

<150>  US 61/779,180
<151>  2013-03-13

<150>  US 61/846,402
<151>  2013-07-15

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  1

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  2
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  2

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  3

His Gln Tyr Tyr Arg Leu Pro Pro Ile Thr 
1               5                   10  


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  4

Asn Tyr Ala Met Ser 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  5

Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  6

Leu Phe Thr Gly Tyr Ala Met Asp Tyr 
1               5                   


<210>  7
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  7

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Asp Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Arg Leu Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 


<210>  8
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  8

Glu Val Met Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ile Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Phe Thr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  9
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala 
1               5                   10                  15      


Tyr Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly 
            20                  25                  30          


Tyr Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu 
        35                  40                  45              


Asn Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu 
    50                  55                  60                  


Gly Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile 
65                  70                  75                  80  


Val Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys 
                85                  90                  95      


Ser Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr 
            100                 105                 110         


Val Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys 
        115                 120                 125             


Ser His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro 
    130                 135                 140                 


Pro Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys 
145                 150                 155                 160 


Ser Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn 
                165                 170                 175     


Tyr Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu Tyr Gln Ile Arg 
            180                 185                 190         


Leu Glu Lys Gly Phe Gln Val Val Val Thr Leu Arg Arg Glu Asp Phe 
        195                 200                 205             


Asp Val Glu Ala Ala Asp Ser Ala Gly Asn Cys Leu Asp Ser Leu Val 
    210                 215                 220                 


Phe Val Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe 
225                 230                 235                 240 


Pro Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile 
                245                 250                 255     


Phe Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr 
            260                 265                 270         


His Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val 
        275                 280                 285             


Trp Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val Gln Ile 
    290                 295                 300                 


Thr Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val Gly Ala Thr 
305                 310                 315                 320 


Ser Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser Asn Ser Lys 
                325                 330                 335     


Leu Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser Ile Glu Asn 
            340                 345                 350         


Gly Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg 
        355                 360                 365             


Tyr Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly 
    370                 375                 380                 


Glu Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly 
385                 390                 395                 400 


Pro Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu Pro 
                405                 410                 415     


Phe Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala Asp Ile Lys 
            420                 425                 430         


Asn Phe Pro Trp Gln Val Phe Phe Asp Asn Pro Trp Ala Gly Gly Ala 
        435                 440                 445             


Leu Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu Gly 
    450                 455                 460                 


Asn Arg Glu Pro Thr Met Tyr Val Gly Ser Thr Ser Val Gln Thr Ser 
465                 470                 475                 480 


Arg Leu Ala Lys Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His 
                485                 490                 495     


Pro Gly Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp 
            500                 505                 510         


Asn Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro 
        515                 520                 525             


Thr Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn Leu 
    530                 535                 540                 


Met Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly Arg Thr Glu Lys 
545                 550                 555                 560 


Arg Asp Arg Ala Val Arg Leu Lys Ala Ala Arg Leu Pro Val Ala Pro 
                565                 570                 575     


Leu Arg Lys Cys Lys Glu Val Lys Val Glu Lys Pro Thr Ala Asp Ala 
            580                 585                 590         


Glu Ala Tyr Val Phe Thr Pro Asn Met Ile Cys Ala Gly Gly Glu Lys 
        595                 600                 605             


Gly Met Asp Ser Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln 
    610                 615                 620                 


Asp Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp 
625                 630                 635                 640 


Gly Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr 
                645                 650                 655     


Val Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu 
            660                 665                 670         


Asp 
    


<210>  10
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  10

Gly Ser Gly Gly Ser 
1               5   


<210>  11
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  11

Gly Gly Gly Ser 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  12

Gly Gly Ser Gly 
1               


<210>  13
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  13

Gly Gly Ser Gly Gly 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  14

Gly Ser Gly Ser Gly 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  15

Gly Ser Gly Gly Gly 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  16

Gly Gly Gly Ser Gly 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  17

Gly Ser Ser Ser Gly 
1               5   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  18

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  19
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  19

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  20
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  20

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  21
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  21

His His His His His 
1               5   


<210>  22
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  22

His His His His His His 
1               5       


<210>  23
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  23

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  24
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  24

Arg Tyr Ile Arg Ser 
1               5   


<210>  25
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  25

Phe His His Thr 
1               


<210>  26
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  26

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  27
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  27

Thr Phe Phe Tyr Gly Gly Cys Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr 
            


<210>  28
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  28

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr 
            


<210>  29
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  29

Cys Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys 
1               5                   10                  15      


Thr Glu Glu Tyr 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  30

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr Cys 
            20  


<210>  31
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  31

Thr Phe Val Tyr Gly Gly Cys Arg Ala Lys Arg Asn Asn Phe Lys Ser 
1               5                   10                  15      


<210>  32
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  32

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  33
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  33

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  34
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  34

Asn Tyr Ala Met Ser 
1               5   


<210>  35
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  35

Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  36

Leu Phe Thr Gly Tyr Ala Met Asp Tyr 
1               5                   


<210>  37
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  37

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Asp Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Arg Leu Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 


<210>  38
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  38

Glu Val Met Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ile Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Phe Thr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  39
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  39

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Phe Thr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  40
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  40

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Phe Thr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  41
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  41

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Phe Thr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  42
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Phe Thr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  43
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  43

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Phe Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Arg Leu Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  44
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  44

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Arg Leu Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  45
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  45

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Arg Leu Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  46
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  46
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagt aattatgcca tgtcttgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaacc attagtagtg gtggtagtca cacctattat      180

ttagacagtg tgaagggtcg attcaccatc tccagagaca attccaagga caccctgtac      240

ctgcaaatga gcagtctgag ggctgaggac acggccctgt attattgtgc aagactgttt      300

accggctatg ctatggacta ttggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  47
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  47
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagt aattatgcca tgtcttgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaacc attagtagtg gtggtagtca cacctattat      180

ttagacagtg tgaagggtcg attcaccatc tccagagaca attccaagga caccctgtac      240

ctgcaaatga acagtctgag ggctgaggac acggccctgt attattgtgc aagactgttt      300

accggctatg ctatggacta ttggggtcaa ggaaccctgg tcaccgtctc ctca            354


<210>  48
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  48
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagt aattatgcca tgtcttgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaacc attagtagtg gtggtagtca cacctattat      180

ttagacagtg tgaagggtcg attcaccatc tccagagaca attccaagga caccctgtac      240

ctgcaaatga gcagtctgag ggctgaggac acggccctgt attattgtgc aagactgttt      300

accggctatg ctatggacta ttggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  49
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  49
gaagtgcagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagt aattatgcca tgtcttgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaacc attagtagtg gtggtagtca cacctattat      180

ttagacagtg tgaagggtcg attcaccatc tccagagaca attccaagaa caccctgtac      240

ctgcaaatga acagtctgag ggctgaggac acggccctgt attattgtgc aagactgttt      300

accggctatg ctatggacta ttggggtcaa ggaaccctgg tcaccgtctc ctca            354


<210>  50
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  50
caaattgttc tcacccagtc tccagcaatc ctgtctctgt ctccagggga acgggccacc       60

atgtcctgca cagccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

ccaggaaagg cccccaaact ctggatttat agcacatcca acctggcttc tggagtccca      180

tctcgcttca gtggcagtgg gtctgggacc ttttacactc tcacaatcag cagcctgcag      240

gctgaagatt ttgccactta ttactgccac cagtattatc gtttaccacc catcacgttc      300

ggtcagggga ccaagctgga gatcaaa                                          327


<210>  51
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  51
caaattgttc tcacccagtc tccagcaacc ctgtctctgt ctccagggga acgggccacc       60

atgtcctgca cagccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

ccaggaaagg cccccaaact ctggatttat agcacatcca acctggcttc tggagtccca      180

tctcgcttca gtggcagtgg gtctgggacc gattacactc tcacaatcag cagcctgcag      240

cctgaagatt ttgccactta ttactgccac cagtattatc gtttaccacc catcacgttc      300

ggtcagggga ccaagctgga gatcaaa                                          327


<210>  52
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  52
caaattgttc tcacccagtc tccagcaacc ctgtctctgt ctccagggga acgggccacc       60

ctgtcctgca cagccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

ccaggaaagg cccccaaact ctggatttat agcacatcca acctggcttc tggagtccca      180

tctcgcttca gtggcagtgg gtctgggacc gattacactc tcacaatcag cagcctgcag      240

cctgaagatt ttgccactta ttactgccac cagtattatc gtttaccacc catcacgttc      300

ggtcagggga ccaagctgga gatcaaa                                          327


<210>  53
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  54
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  54

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10              


<210>  55
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  55

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  56
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  56

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  57
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  57

Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  58
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  59
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  59

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
1               5                   10              


<210>  60
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  60

Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  61
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  61

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  62
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  62

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10              


<210>  63
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  63

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  64
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  64

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  65
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  65

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  66
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  66

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  67
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  67

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  68
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  68

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  69
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  69

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


