                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  ERYTHROFERRONE AND ERFE POLYPEPTIDES AND METHODS OF REGULATING 
       IRON METABOLISM

<130>  034044.119WO1

<150>  61/721,322
<151>  2012-11-01

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Pro Ala Arg Arg Pro Ala Gly Ala Arg Leu Leu Leu Val Tyr 
1               5                   10                  15      


Ala Gly Leu Leu Ala Ala Ala Ala Ala Gly Leu Gly Ser Pro Glu Pro 
            20                  25                  30          


Gly Ala Pro Ser Arg Ser Arg Ala Arg Arg Glu Pro Pro Pro Gly Asn 
        35                  40                  45              


Glu Leu Pro Arg Gly Pro Gly Glu Ser Arg Ala Gly Pro Ala Ala Arg 
    50                  55                  60                  


Pro Pro Glu Pro Thr Ala Glu Arg Ala His Ser Val Asp Pro Arg Asp 
65                  70                  75                  80  


Ala Trp Met Leu Phe Val Arg Gln Ser Asp Lys Gly Val Asn Gly Lys 
                85                  90                  95      


Lys Arg Ser Arg Gly Lys Ala Lys Lys Leu Lys Phe Gly Leu Pro Gly 
            100                 105                 110         


Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Ile Ile Pro 
        115                 120                 125             


Pro Glu Ala Leu Leu Lys Glu Phe Gln Leu Leu Leu Lys Gly Ala Val 
    130                 135                 140                 


Arg Gln Arg Glu Arg Ala Glu Pro Glu Pro Cys Thr Cys Gly Pro Ala 
145                 150                 155                 160 


Gly Pro Val Ala Ala Ser Leu Ala Pro Val Ser Ala Thr Ala Gly Glu 
                165                 170                 175     


Asp Asp Asp Asp Val Val Gly Asp Val Leu Ala Leu Leu Ala Ala Pro 
            180                 185                 190         


Leu Ala Pro Gly Pro Arg Ala Pro Arg Val Glu Ala Ala Phe Leu Cys 
        195                 200                 205             


Arg Leu Arg Arg Asp Ala Leu Val Glu Arg Arg Ala Leu His Glu Leu 
    210                 215                 220                 


Gly Val Tyr Tyr Leu Pro Asp Ala Glu Gly Ala Phe Arg Arg Gly Pro 
225                 230                 235                 240 


Gly Leu Asn Leu Thr Ser Gly Gln Tyr Arg Ala Pro Val Ala Gly Phe 
                245                 250                 255     


Tyr Ala Leu Ala Ala Thr Leu His Val Ala Leu Gly Glu Pro Pro Arg 
            260                 265                 270         


Arg Gly Pro Pro Arg Pro Arg Asp His Leu Arg Leu Leu Ile Cys Ile 
        275                 280                 285             


Gln Ser Arg Cys Gln Arg Asn Ala Ser Leu Glu Ala Ile Met Gly Leu 
    290                 295                 300                 


Glu Ser Ser Ser Glu Leu Phe Thr Ile Ser Val Asn Gly Val Leu Tyr 
305                 310                 315                 320 


Leu Gln Met Gly Gln Trp Thr Ser Val Phe Leu Asp Asn Ala Ser Gly 
                325                 330                 335     


Cys Ser Leu Thr Val Arg Ser Gly Ser His Phe Ser Ala Val Leu Leu 
            340                 345                 350         


Gly Val 
        


<210>  2
<211>  340
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Ser Thr Arg Arg Pro Val Gly Ala Arg Thr Leu Leu Ala Cys 
1               5                   10                  15      


Ala Ser Leu Leu Ala Ala Met Gly Leu Gly Val Pro Glu Ser Ala Glu 
            20                  25                  30          


Pro Val Gly Thr His Ala Arg Pro Gln Pro Pro Gly Ala Glu Leu Pro 
        35                  40                  45              


Ala Pro Pro Ala Asn Ser Pro Pro Glu Pro Thr Ile Ala His Ala His 
    50                  55                  60                  


Ser Val Asp Pro Arg Asp Ala Trp Met Leu Phe Val Lys Gln Ser Asp 
65                  70                  75                  80  


Lys Gly Ile Asn Ser Lys Arg Arg Ser Lys Ala Arg Arg Leu Lys Leu 
                85                  90                  95      


Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
            100                 105                 110         


Pro Phe Ile Pro Ser Glu Val Leu Leu Lys Glu Phe Gln Leu Leu Leu 
        115                 120                 125             


Lys Gly Ala Val Arg Gln Arg Glu Ser His Leu Glu His Cys Thr Arg 
    130                 135                 140                 


Asp Leu Thr Thr Pro Ala Ser Gly Ser Pro Ser Arg Val Pro Ala Ala 
145                 150                 155                 160 


Gln Glu Leu Asp Ser Gln Asp Pro Gly Ala Leu Leu Ala Leu Leu Ala 
                165                 170                 175     


Ala Thr Leu Ala Gln Gly Pro Arg Ala Pro Arg Val Glu Ala Ala Phe 
            180                 185                 190         


His Cys Arg Leu Arg Arg Asp Val Gln Val Asp Arg Arg Ala Leu His 
        195                 200                 205             


Glu Leu Gly Ile Tyr Tyr Leu Pro Glu Val Glu Gly Ala Phe His Arg 
    210                 215                 220                 


Gly Pro Gly Leu Asn Leu Thr Ser Gly Gln Tyr Thr Ala Pro Val Ala 
225                 230                 235                 240 


Gly Phe Tyr Ala Leu Ala Ala Thr Leu His Val Ala Leu Thr Glu Gln 
                245                 250                 255     


Pro Arg Lys Gly Pro Thr Arg Pro Arg Asp Arg Leu Arg Leu Leu Ile 
            260                 265                 270         


Cys Ile Gln Ser Leu Cys Gln His Asn Ala Ser Leu Glu Thr Val Met 
        275                 280                 285             


Gly Leu Glu Asn Ser Ser Glu Leu Phe Thr Ile Ser Val Asn Gly Val 
    290                 295                 300                 


Leu Tyr Leu Gln Ala Gly His Tyr Thr Ser Val Phe Leu Asp Asn Ala 
305                 310                 315                 320 


Ser Gly Ser Ser Leu Thr Val Arg Ser Gly Ser His Phe Ser Ala Ile 
                325                 330                 335     


Leu Leu Gly Leu 
            340 


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.

<400>  3

Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.

<400>  4

Ala His Ser Val Asp Pro Arg Asp Ala Trp Met Leu Phe Val 
1               5                   10                  


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Ala His Ser Val Asp Pro Arg Asp Ala Trp Met Leu Phe Val Xaa Gln 
1               5                   10                  15      


Ser Asp Lys Gly Xaa Asn 
            20          


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.

<400>  6

Leu Leu Lys Glu Phe Gln Leu Leu Leu Lys Gly Ala Val Arg Gln Arg 
1               5                   10                  15      


Glu 
    


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.

<400>  7

Gly Pro Arg Ala Pro Arg Val Glu Ala Ala Phe 
1               5                   10      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Val Xaa Arg Arg Ala Leu His Glu Leu Gly Xaa Tyr Tyr Leu Pro Xaa 
1               5                   10                  15      


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.

<400>  9

Gly Leu Asn Leu Thr Ser Gly Gln Tyr 
1               5                   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.

<400>  10

Ala Pro Val Ala Gly Phe Tyr Ala Leu Ala Ala Thr Leu His Val Ala 
1               5                   10                  15      


Leu 
    


<210>  11
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Xaa Met Gly Leu Glu Xaa Ser Ser Glu Leu Phe Thr Ile Ser Val Asn 
1               5                   10                  15      


Gly Val Leu Tyr Leu Gln 
            20          


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.

<400>  12

Ser Ser Glu Leu Phe Thr Ile Ser Val Asn Gly Val Leu Tyr Leu Gln 
1               5                   10                  15      


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.

<400>  13

Thr Ser Val Phe Leu Asp Asn Ala Ser Gly 
1               5                   10  


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.

<400>  14

Ser Leu Thr Val Arg Ser Gly Ser His Phe Ser Ala 
1               5                   10          


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Ser Leu Thr Val Arg Ser Gly Ser His Phe Ser Ala Xaa Leu Leu Gly 
1               5                   10                  15      


Xaa 
    


<210>  16
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Phe Gln Leu Leu Leu Lys Gly Ala Val Arg Gln Arg Glu Arg Ala 
1               5                   10                  15      


Glu Pro Glu Pro Cys Thr Cys Gly Pro Ala Gly Pro Val Ala Ala Ser 
            20                  25                  30          


Leu Ala Pro Val Ser Ala Thr Ala Gly Glu Asp Asp Asp Asp Val Val 
        35                  40                  45              


Gly Asp Val Leu Ala Leu Leu Ala Ala Pro Leu Ala Pro Gly Pro Arg 
    50                  55                  60                  


Ala Pro Arg Val Glu Ala Ala Phe Leu Cys Arg Leu Arg Arg Asp Ala 
65                  70                  75                  80  


Leu Val Glu Arg Arg Ala Leu His Glu Leu Gly Val Tyr Tyr Leu Pro 
                85                  90                  95      


Asp Ala Glu Gly Ala Phe Arg Arg Gly Pro Gly Leu Asn Leu Thr Ser 
            100                 105                 110         


Gly Gln Tyr Arg Ala Pro Val Ala Gly Phe Tyr Ala Leu Ala Ala Thr 
        115                 120                 125             


Leu His Val Ala Leu Gly Glu Pro Pro Arg Arg Gly Pro Pro Arg Pro 
    130                 135                 140                 


Arg Asp His Leu Arg Leu Leu Ile Cys Ile Gln Ser Arg Cys Gln Arg 
145                 150                 155                 160 


Asn Ala Ser Leu Glu Ala Ile Met Gly Leu Glu Ser Ser Ser Glu Leu 
                165                 170                 175     


Phe Thr Ile Ser Val Asn Gly Val Leu Tyr Leu Gln Met Gly Gln Trp 
            180                 185                 190         


Thr Ser Val Phe Leu Asp Asn Ala Ser Gly Cys Ser Leu Thr Val Arg 
        195                 200                 205             


Ser Gly Ser His Phe Ser Ala Val Leu Leu Gly Val 
    210                 215                 220 


<210>  17
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Pro Ala Arg Arg Pro Ala Gly Ala Arg Leu Leu Leu Val Tyr 
1               5                   10                  15      


Ala Gly Leu Leu Ala Ala Ala Ala Ala Gly Leu Gly Ser Pro Glu Pro 
            20                  25                  30          


Gly Ala Pro Ser Arg Ser Arg Ala Arg Arg Glu Pro Pro Pro Gly Asn 
        35                  40                  45              


Glu Leu Pro Arg Gly Pro Gly Glu Ser Arg Ala Gly Pro Ala Ala Arg 
    50                  55                  60                  


Pro Pro Glu Pro Thr Ala Glu Arg Ala His Ser Val Asp Pro Arg Asp 
65                  70                  75                  80  


Ala Trp Met Leu Phe Val Arg Gln Ser Asp Lys Gly Val Asn Gly Lys 
                85                  90                  95      


Lys Arg Ser Arg Gly Lys Ala Lys Lys Leu Lys Phe Gly Leu Pro Gly 
            100                 105                 110         


Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Ile Ile Pro 
        115                 120                 125             


Pro Glu Ala Leu Leu Lys 
    130                 


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide based on sequences from Homo sapiens and Mus 
       musculus.

<400>  18

Pro Ser Arg Val Pro Ala Ala Gln Glu Leu 
1               5                   10  


