                         SEQUENCE LISTING

<110>  Ipsen Pharma, S.A.S.
       DONG, Zheng Xin
       SHEN, Yeelana
       KIM, Sun Hyuk
 
<120>  Somatostatin-Dopamine Chimeric Analogs

<130>  225IPH

<140>  US 61/721372
<141>  2012-11-01

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinyl)-propionyl via 

       a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  1

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinyl)-butanoyl via 

       a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  2

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinyl)-pentanoyl 

       via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  3

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  4

Tyr Xaa Arg Phe Xaa Xaa Lys Thr Phe 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  modified with 4-Fl

<400>  5

Tyr Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  6

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 3,4-Fl

<400>  7

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 3,5-Fl

<400>  8

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 3-Fl

<400>  9

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 2-Fl

<400>  10

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 2,3,4,5,6-Fl

<400>  11

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  12

Xaa Arg Phe Xaa Xaa Lys Thr Tyr 
1               5               


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl 

       (Dop1) via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl 

       (Dop1) via an amide bond at the epsilon-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  13

Lys Xaa Arg Phe Xaa Xaa Lys Thr Tyr 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl 

       (Dop1) via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl 

       (Dop1) via an amide bond at the epsilon-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  14

Lys Xaa Arg Phe Xaa Xaa Lys Thr Phe 
1               5                   


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO2), via a 

       psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  15

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO) R-stereoisomer 

       form, via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  16

Xaa Arg Phe Xaa Xaa Lys Thr Tyr 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO) S-stereoisomer 

       form, via a psi(CH2NH) bond via at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  17

Xaa Arg Phe Xaa Xaa Lys Thr Tyr 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO), via a 

       psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  18

Xaa Arg Phe Xaa Xaa Lys Thr Tyr 
1               5               


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether is modified to (SO), via an amide bond at 
       the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  modified with 4-Fl

<400>  19

Tyr Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO), via a 

       psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  20

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO), via an amide 
       bond at the 

alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  21

Tyr Xaa Arg Phe Xaa Xaa Lys Thr Phe 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO), via an amide 
       bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether is modified to (SO), via an amide bond at 
       the epsilon-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  22

Lys Xaa Arg Phe Xaa Xaa Lys Thr Tyr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO), via an amide 
       bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether is modified to (SO), via an amide bond at 
       the epsilon-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  23

Lys Xaa Arg Phe Xaa Xaa Lys Thr Phe 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO2), via an amide 
       bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  24

Tyr Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO2), via a 

       psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  25

Xaa Arg Phe Xaa Xaa Lys Thr Tyr 
1               5               


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       in which the thioether group is modified to (SO2), via an amide 
       bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  26

Tyr Xaa Arg Phe Xaa Xaa Lys Thr Phe 
1               5                   


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with 
       3-[N-(D-6-methyl-8beta-ergolinylmethyl)]-aminopropionyl 

       via a psi(CH2NAc) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  27

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  28

Xaa Arg Phe Xaa Xaa Lys Thr Phe 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  29

Xaa Arg Phe Xaa Xaa Lys Thr Phe 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  30

Xaa Arg Phe Xaa Xaa Lys Thr Tyr 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  31

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with 3-[N-acetyl-N-(D-6-methyl-8beta-ergolinylmethyl)]- 
       aminopropionyl via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  modified with 4-Fl

<400>  32

Tyr Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with 3-[N-acetyl-N-(D-6-methyl-8beta-ergolinylmethyl)]- 
       aminopropionyl via a psi(CH2NAc) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  33

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with 3-[N-acetyl-N-(D-6-methyl-8beta-ergolinylmethyl)]-

       aminopropionyl via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  via a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  modified with 4-Fl

<400>  34

Tyr Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with two (D-6-methyl-8beta-ergolinylmethyl)thioacetyl 

       (Dop1) moieties via psi (CH2N) bonds at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  35

Xaa Arg Phe Xaa Xaa Lys Thr Phe 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with 3-[N-acetyl-N-(D-6-methyl-8beta-ergolinylmethyl)]- 
       aminopropionyl via a psi(CH2NH) bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  36

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-ornithine (D-Orn)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  37

Tyr Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  38

Tyr Lys Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  39

Tyr Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  40

Tyr Xaa Arg Phe Phe Xaa Lys Thr Tyr 
1               5                   


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  41

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with two (D-6-methyl-8beta-ergolinylmethyl)thioacetyl

       (Dop1) moieties via psi(CH2N) bonds at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  42

Xaa Arg Phe Xaa Xaa Lys Thr Tyr 
1               5               


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Tyr

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  43

Xaa Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = beta-(3-pyridinyl)alanine (3-Pal)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  44

Tyr Xaa Arg Phe Xaa Xaa Lys Thr Phe 
1               5                   


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with two (D-6-methyl-8beta-ergolinylmethyl)thioacetyl 

       (Dop1) moieties via psi(CH2N) bonds at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  45

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with two (D-6-methyl-8beta-ergolinylmethyl)thioacetyl 

       (Dop1) moieties via psi(CH2N) bonds at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  46

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Tyr

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  47

Xaa Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with [N-(D-6-methyl-8beta-ergolinylmethyl)-N- 

       (methylsulfonyl)]-aminopropionyl via an amide bond at the 
       alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  modified with 4-Fl

<400>  48

Tyr Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  49

Tyr Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  50

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Tyr

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = beta-(4-pyridinyl)alanine (4-Pal)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  51

Xaa Xaa Arg Xaa Tyr Xaa Lys Thr Phe 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the alpha-amino group

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)
       via an amide bond at the epsilon-amino group

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a psi(CH2NH) bond

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  modified with 4-Fl

<400>  52

Lys Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with [D-6-methyl-8beta-ergolinylmethyl]-sulfonylpropyl

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  modified with 4-Fl

<400>  53

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  labeled with 125-Iodine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Phe

<220>
<221>  MOD_RES
<222>  (3)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  54

Tyr Xaa Cys Tyr Xaa Lys Val Cys Thr 
1               5                   


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)

<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-2,4-diaminobutyric acid (D-Dab)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = D-Trp

<400>  55

Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5               


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-2,4-diaminobutyric acid (D-Dab)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  56

Tyr Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (D-6-methyl-8beta-ergolinylmethyl)thioacetyl (Dop1)

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-2,4-diaminobutyric acid (D-Dab)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa = D-Trp

<400>  57

Lys Xaa Arg Phe Phe Xaa Lys Thr Phe 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Tyr or Tyr or  D-Lys or Lys or deleted

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = Phe or beta-(2-pyridinyl)alanine (2-Pal) or 
       beta-(3-pyridinyl)alanine (3-Pal) or beta-(4-pyridinyl)alanine 
       (4-Pal)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa = Phe or 2-FPhe or 3-FPhe or 4-FPhe or 3,4-FPhe or 3,5-FPhe 
       or 2,3,4,5,6-FPhe or Tyr

<400>  58

Xaa Xaa Arg Phe Xaa Xaa Lys Thr Xaa 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin-dopamine chimeric peptide analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = D-Tyr or Tyr or  D-Lys or Lys or deleted

<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  a pseudopeptide bond

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = D-Lys

<220>
<221>  MOD_RES
<222>  (2)..(9)
<223>  cyclized with a lactam bridge

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa = Phe or beta-(2-pyridinyl)alanine (2-Pal) or 
       beta-(3-pyridinyl)alanine (3-Pal) or beta-(4-pyridinyl)alanine 
       (4-Pal)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa = Phe or 2-FPhe or 3-FPhe or 4-FPhe or 3,4-FPhe or 3,5-FPhe 
       or 2,3,4,5,6-FPhe or Tyr

<400>  59

Xaa Xaa Arg Phe Xaa Xaa Lys Thr Xaa 
1               5                   


