                         SEQUENCE LISTING

<110>  Gilead Sciences, Inc.
 
<120>  THERAPEUTIC AND DIAGNOSTIC METHODS RELATED TO LYSYL OXIDASE-LIKE 
       2 (LOXL2)

<130>  GILE-077/03WO

<150>  US 61/720,350
<151>  2012-10-30

<150>  US 61/724,858
<151>  2012-11-09

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  774
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(774)
<223>  LOXL2

<400>  1

Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu 
1               5                   10                  15      


Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His 
            20                  25                  30          


Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln 
        35                  40                  45              


Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln Lys 
    50                  55                  60                  


Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly Gln Trp 
65                  70                  75                  80  


Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His Val Val 
                85                  90                  95      


Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Ala Ser Ser 
            100                 105                 110         


Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu His Cys 
        115                 120                 125             


Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr Ser Asn Gly Trp Gly 
    130                 135                 140                 


Val Thr Asp Cys Lys His Thr Glu Asp Val Gly Val Val Cys Ser Asp 
145                 150                 155                 160 


Lys Arg Ile Pro Gly Phe Lys Phe Asp Asn Ser Leu Ile Asn Gln Ile 
                165                 170                 175     


Glu Asn Leu Asn Ile Gln Val Glu Asp Ile Arg Ile Arg Ala Ile Leu 
            180                 185                 190         


Ser Thr Tyr Arg Lys Arg Thr Pro Val Met Glu Gly Tyr Val Glu Val 
        195                 200                 205             


Lys Glu Gly Lys Thr Trp Lys Gln Ile Cys Asp Lys His Trp Thr Ala 
    210                 215                 220                 


Lys Asn Ser Arg Val Val Cys Gly Met Phe Gly Phe Pro Gly Glu Arg 
225                 230                 235                 240 


Thr Tyr Asn Thr Lys Val Tyr Lys Met Phe Ala Ser Arg Arg Lys Gln 
                245                 250                 255     


Arg Tyr Trp Pro Phe Ser Met Asp Cys Thr Gly Thr Glu Ala His Ile 
            260                 265                 270         


Ser Ser Cys Lys Leu Gly Pro Gln Val Ser Leu Asp Pro Met Lys Asn 
        275                 280                 285             


Val Thr Cys Glu Asn Gly Leu Pro Ala Val Val Ser Cys Val Pro Gly 
    290                 295                 300                 


Gln Val Phe Ser Pro Asp Gly Pro Ser Arg Phe Arg Lys Ala Tyr Lys 
305                 310                 315                 320 


Pro Glu Gln Pro Leu Val Arg Leu Arg Gly Gly Ala Tyr Ile Gly Glu 
                325                 330                 335     


Gly Arg Val Glu Val Leu Lys Asn Gly Glu Trp Gly Thr Val Cys Asp 
            340                 345                 350         


Asp Lys Trp Asp Leu Val Ser Ala Ser Val Val Cys Arg Glu Leu Gly 
        355                 360                 365             


Phe Gly Ser Ala Lys Glu Ala Val Thr Gly Ser Arg Leu Gly Gln Gly 
    370                 375                 380                 


Ile Gly Pro Ile His Leu Asn Glu Ile Gln Cys Thr Gly Asn Glu Lys 
385                 390                 395                 400 


Ser Ile Ile Asp Cys Lys Phe Asn Ala Glu Ser Gln Gly Cys Asn His 
                405                 410                 415     


Glu Glu Asp Ala Gly Val Arg Cys Asn Thr Pro Ala Met Gly Leu Gln 
            420                 425                 430         


Lys Lys Leu Arg Leu Asn Gly Gly Arg Asn Pro Tyr Glu Gly Arg Val 
        435                 440                 445             


Glu Val Leu Val Glu Arg Asn Gly Ser Leu Val Trp Gly Met Val Cys 
    450                 455                 460                 


Gly Gln Asn Trp Gly Ile Val Glu Ala Met Val Val Cys Arg Gln Leu 
465                 470                 475                 480 


Gly Leu Gly Phe Ala Ser Asn Ala Phe Gln Glu Thr Trp Tyr Trp His 
                485                 490                 495     


Gly Asp Val Asn Ser Asn Lys Val Val Met Ser Gly Val Lys Cys Ser 
            500                 505                 510         


Gly Thr Glu Leu Ser Leu Ala His Cys Arg His Asp Gly Glu Asp Val 
        515                 520                 525             


Ala Cys Pro Gln Gly Gly Val Gln Tyr Gly Ala Gly Val Ala Cys Ser 
    530                 535                 540                 


Glu Thr Ala Pro Asp Leu Val Leu Asn Ala Glu Met Val Gln Gln Thr 
545                 550                 555                 560 


Thr Tyr Leu Glu Asp Arg Pro Met Phe Met Leu Gln Cys Ala Met Glu 
                565                 570                 575     


Glu Asn Cys Leu Ser Ala Ser Ala Ala Gln Thr Asp Pro Thr Thr Gly 
            580                 585                 590         


Tyr Arg Arg Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln 
        595                 600                 605             


Ser Asp Phe Arg Pro Lys Asn Gly Arg His Ala Trp Ile Trp His Asp 
    610                 615                 620                 


Cys His Arg His Tyr His Ser Met Glu Val Phe Thr His Tyr Asp Leu 
625                 630                 635                 640 


Leu Asn Leu Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe 
                645                 650                 655     


Cys Leu Glu Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Asn Tyr Glu 
            660                 665                 670         


Cys Ala Asn Phe Gly Asp Gln Gly Ile Thr Met Gly Cys Trp Asp Met 
        675                 680                 685             


Tyr Arg His Asp Ile Asp Cys Gln Trp Val Asp Ile Thr Asp Val Pro 
    690                 695                 700                 


Pro Gly Asp Tyr Leu Phe Gln Val Val Ile Asn Pro Asn Phe Glu Val 
705                 710                 715                 720 


Ala Glu Ser Asp Tyr Ser Asn Asn Ile Met Lys Cys Arg Ser Arg Tyr 
                725                 730                 735     


Asp Gly His Arg Ile Trp Met Tyr Asn Cys His Ile Gly Gly Ser Phe 
            740                 745                 750         


Ser Glu Glu Thr Glu Lys Lys Phe Glu His Phe Ser Gly Leu Leu Asn 
        755                 760                 765             


Asn Gln Leu Ser Pro Gln 
    770                 


<210>  2
<211>  227
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(227)
<223>  catalytic domain of LOXL2 protein

<400>  2

Pro Asp Leu Val Leu Asn Ala Glu Met Val Gln Gln Thr Thr Tyr Leu 
1               5                   10                  15      


Glu Asp Arg Pro Met Phe Met Leu Gln Cys Ala Met Glu Glu Asn Cys 
            20                  25                  30          


Leu Ser Ala Ser Ala Ala Gln Thr Asp Pro Thr Thr Gly Tyr Arg Arg 
        35                  40                  45              


Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln Ser Asp Phe 
    50                  55                  60                  


Arg Pro Lys Asn Gly Arg His Ala Trp Ile Trp His Asp Cys His Arg 
65                  70                  75                  80  


His Tyr His Ser Met Glu Val Phe Thr His Tyr Asp Leu Leu Asn Leu 
                85                  90                  95      


Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe Cys Leu Glu 
            100                 105                 110         


Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Asn Tyr Glu Cys Ala Asn 
        115                 120                 125             


Phe Gly Asp Gln Gly Ile Thr Met Gly Cys Trp Asp Met Tyr Arg His 
    130                 135                 140                 


Asp Ile Asp Cys Gln Trp Val Asp Ile Thr Asp Val Pro Pro Gly Asp 
145                 150                 155                 160 


Tyr Leu Phe Gln Val Val Ile Asn Pro Asn Phe Glu Val Ala Glu Ser 
                165                 170                 175     


Asp Tyr Ser Asn Asn Ile Met Lys Cys Arg Ser Arg Tyr Asp Gly His 
            180                 185                 190         


Arg Ile Trp Met Tyr Asn Cys His Ile Gly Gly Ser Phe Ser Glu Glu 
        195                 200                 205             


Thr Glu Lys Lys Phe Glu His Phe Ser Gly Leu Leu Asn Asn Gln Leu 
    210                 215                 220                 


Ser Pro Gln 
225         


<210>  3
<211>  227
<212>  PRT
<213>  Mus musculus


<220>
<221>  DOMAIN
<222>  (1)..(227)
<223>  catalytic domain of LOXL2 protein

<400>  3

Pro Asp Leu Val Leu Asn Ala Glu Ile Val Gln Gln Thr Ala Tyr Leu 
1               5                   10                  15      


Glu Asp Arg Pro Met Ser Leu Leu Gln Cys Ala Met Glu Glu Asn Cys 
            20                  25                  30          


Leu Ser Ala Ser Ala Val His Thr Asp Pro Thr Arg Gly His Arg Arg 
        35                  40                  45              


Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln Ser Asp Phe 
    50                  55                  60                  


Arg Pro Lys Asn Gly Arg His Ala Trp Ile Trp His Asp Cys His Arg 
65                  70                  75                  80  


His Tyr His Ser Met Glu Val Phe Thr Tyr Tyr Asp Leu Leu Ser Leu 
                85                  90                  95      


Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe Cys Leu Glu 
            100                 105                 110         


Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Ser Tyr Glu Cys Ala Asn 
        115                 120                 125             


Phe Gly Glu Gln Gly Ile Thr Met Gly Cys Trp Asp Met Tyr Arg His 
    130                 135                 140                 


Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Pro Pro Gly Asp 
145                 150                 155                 160 


Tyr Leu Phe Gln Val Val Ile Asn Pro Asn Tyr Glu Val Pro Glu Ser 
                165                 170                 175     


Asp Phe Ser Asn Asn Ile Met Lys Cys Arg Ser Arg Tyr Asp Gly Tyr 
            180                 185                 190         


Arg Ile Trp Met Tyr Asn Cys His Val Gly Gly Ala Phe Ser Glu Glu 
        195                 200                 205             


Thr Glu Gln Lys Phe Glu His Phe Ser Gly Leu Leu Asn Asn Gln Leu 
    210                 215                 220                 


Ser Val Gln 
225         


<210>  4
<211>  227
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  DOMAIN
<222>  (1)..(227)
<223>  catalytic domain of LOXL2 protein

<400>  4

Pro Asp Leu Val Leu Asn Ala Glu Ile Val Gln Gln Thr Ala Tyr Leu 
1               5                   10                  15      


Glu Asp Arg Pro Met Ala Leu Leu Gln Cys Ala Met Glu Glu Asn Cys 
            20                  25                  30          


Leu Ser Ala Ser Ala Val His Thr Asp Pro Thr Arg Gly His Arg Arg 
        35                  40                  45              


Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln Ser Asp Phe 
    50                  55                  60                  


Arg Pro Lys Asn Gly Arg His Ala Trp Ile Trp His Asp Cys His Arg 
65                  70                  75                  80  


His Tyr His Ser Met Glu Val Phe Thr Tyr Tyr Asp Leu Leu Ser Leu 
                85                  90                  95      


Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe Cys Leu Glu 
            100                 105                 110         


Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Ser Tyr Glu Cys Ala Asn 
        115                 120                 125             


Phe Gly Glu Gln Gly Ile Thr Met Gly Cys Trp Asp Met Tyr Arg His 
    130                 135                 140                 


Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Pro Pro Gly Asp 
145                 150                 155                 160 


Tyr Leu Phe Gln Val Val Ile Asn Pro Asn Tyr Glu Val Pro Glu Ser 
                165                 170                 175     


Asp Phe Ser Asn Asn Ile Met Lys Cys Arg Ser Arg Tyr Asp Gly Tyr 
            180                 185                 190         


Arg Ile Trp Met Tyr Asn Cys His Val Gly Gly Ala Phe Ser Glu Glu 
        195                 200                 205             


Thr Glu Gln Lys Phe Glu His Phe Ser Gly Leu Leu Asn Asn Gln Leu 
    210                 215                 220                 


Ser Val Gln 
225         


<210>  5
<211>  227
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  DOMAIN
<222>  (1)..(227)
<223>  catalytic domain of LOXL2 protein

<400>  5

Pro Asp Leu Val Leu Asn Ala Glu Met Val Gln Gln Thr Thr Tyr Leu 
1               5                   10                  15      


Glu Asp Arg Pro Met Phe Met Leu Gln Cys Ala Met Glu Glu Asn Cys 
            20                  25                  30          


Leu Ser Ala Ser Ala Ala Gln Thr Asn Pro Thr Thr Gly Tyr Arg Arg 
        35                  40                  45              


Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln Ser Asp Phe 
    50                  55                  60                  


Arg Pro Lys Asn Gly Arg His Ala Trp Ile Trp His Asp Cys His Arg 
65                  70                  75                  80  


His Tyr His Ser Met Glu Val Phe Thr His Tyr Asp Leu Leu Asn Leu 
                85                  90                  95      


Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe Cys Leu Glu 
            100                 105                 110         


Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Asn Tyr Glu Cys Ala Asn 
        115                 120                 125             


Phe Gly Asp Gln Gly Ile Thr Met Gly Cys Trp Asp Met Tyr Arg His 
    130                 135                 140                 


Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Pro Pro Gly Asp 
145                 150                 155                 160 


Tyr Leu Phe Gln Val Val Ile Asn Pro Asn Phe Glu Val Ala Glu Ser 
                165                 170                 175     


Asp Tyr Ser Asn Asn Ile Met Lys Cys Arg Ser Arg Tyr Asp Gly His 
            180                 185                 190         


Arg Ile Trp Met Tyr Asn Cys His Ile Gly Gly Ser Phe Ser Glu Glu 
        195                 200                 205             


Thr Glu Lys Lys Phe Glu His Phe Ser Gly Leu Leu Asn Asn Gln Leu 
    210                 215                 220                 


Ser Pro Gln 
225         


<210>  6
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  CHAIN
<222>  (1)..(135)
<223>  heavy chain variable region

<400>  6

Met Glu Trp Ser Arg Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Thr Tyr Tyr Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser 
    130                 135 


<210>  7
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  CHAIN
<222>  (1)..(132)
<223>  light chain variable region

<400>  7

Met Arg Cys Leu Ala Glu Phe Leu Gly Leu Leu Val Leu Trp Ile Pro 
1               5                   10                  15      


Gly Ala Ile Gly Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Ser 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  CHAIN
<222>  (1)..(116)
<223>  heavy chain variable region

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DOMAIN
<222>  (1)..(112)
<223>  light chain variable region

<400>  9

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  10
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  heavy chain variable region

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  heavy chain variable region

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  12
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  heavy chain variable region

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DOMAIN
<222>  (1)..(112)
<223>  light chain variable region

<400>  13

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  14
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DOMAIN
<222>  (1)..(112)
<223>  light chain variable region

<400>  14

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  15

Val Trp Gly Met Val Cys Gly Gln Asn Trp Gly Ile Val Glu Ala 
1               5                   10                  15  


<210>  16

<400>  16
000

<210>  17
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  17

Val Glu Ala Met Val Val Cys Arg Gln Leu Gly Leu Gly Phe Ala 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Phe Ala Ser Asn Ala Phe Gln Glu Thr Trp Tyr Trp His Gly 
1               5                   10                  15  


<210>  19
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  19

Val Arg Leu Arg Gly Gly Ala Tyr Ile Gly Glu Gly Arg Val Glu Val 
1               5                   10                  15      


Leu Lys Asn Gly Glu Trp Gly Thr Val Cys Asp Asp Lys Trp Asp Leu 
            20                  25                  30          


Val Ser Ala Ser Val Val Cys Arg Glu Leu Gly Phe Gly Ser Ala Lys 
        35                  40                  45              


Glu Ala Val Thr Gly Ser Arg Leu Gly Gln Gly Ile Gly Pro Ile His 
    50                  55                  60                  


Leu Asn Glu Ile Gln Cys Thr Gly Asn Glu Lys Ser Ile Ile Asp Cys 
65                  70                  75                  80  


Lys Phe Asn Ala Glu Ser Gln Gly Cys Asn His Glu Glu Asp Ala Gly 
                85                  90                  95      


Val Arg Cys Asn Leu Arg Leu Asn Gly Gly Arg Asn Pro Tyr Glu Gly 
            100                 105                 110         


Arg Val Glu Val Leu Val Glu Arg Asn Gly Ser Leu Val Trp Gly Met 
        115                 120                 125             


Val Cys Gly Gln Asn Trp Gly Ile Val Glu Ala Met Val Val Cys Arg 
    130                 135                 140                 


Gln Leu Gly Leu Gly Phe Ala Ser Asn Ala Phe Gln Glu Thr Trp Tyr 
145                 150                 155                 160 


Trp His Gly Asp Val Asn Ser Asn Lys Val Val Met Ser Gly Val Lys 
                165                 170                 175     


Cys Ser Gly Thr Glu Leu Ser Leu Ala His Cys Arg His Asp Gly Glu 
            180                 185                 190         


Asp Val Ala Cys Pro Gln Gly Gly Val Gln Tyr Gly Ala Gly Val Ala 
        195                 200                 205             


Cys Ser 
    210 


<210>  20
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain humanized anti-LOXL2 antibody

<400>  20

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  21
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding light chain of a humanized anti-LOXL2 
       antibody:

<400>  21
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg cgcgcgatgt       60

gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc      120

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      180

ttcctgcaga agccagggca gtctccacag ttcctgatct atcggatgtc caaccttgcc      240

tcaggagtgc cagataggtt cagtggcagc gggtcaggga cagacttcac actgaaaatc      300

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaacatct agaatatcct      360

tacaccttcg gcggagggac caaggtggag atcaaacgaa ctgtggctgc accatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      720


<210>  22
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  CHAIN
<222>  (2)..(219)
<223>  light chain polypeptide

<400>  22

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  23
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct encoding SEQ ID NO:22

<400>  23
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      120

ttcctgcaga agccagggca gtctccacag ttcctgatct atcggatgtc caaccttgcc      180

tcaggagtgc cagataggtt cagtggcagc gggtcaggga cagacttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaacatct agaatatcct      300

tacaccttcg gcggagggac caaggtggag atcaaacgaa ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      660


<210>  24
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain humanized anti-LOXL2 antibody

<400>  24

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Thr Tyr Tyr Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460         


<210>  25
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding a heavy chain humanized anti-LOXL2 antibody

<400>  25
atgggttgga gcctcatctt gctcttcctt gtcgctgttg ctacgcgtgt ccactcccag       60

gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc      120

tgcaaggctt ctggatacgc cttcacttat tacttgatag agtgggtgag acaggcccct      180

ggacaagggc ttgagtggat cggagtgatt aatcctggaa gtggtggtac taactacaat      240

gagaagttca agggcagagc cacgatcacc gcggacaaat ccacgagcac agcctacatg      300

gagctgagca gcctgagatc tgaggacacc gccgtgtatt tctgtgcgag aaactggatg      360

aactttgact actgggggca agggaccacg gtcaccgtct cctcagcttc caccaagggc      420

ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac agccgccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcacga agacctacac ctgcaatgta      660

gatcacaagc ccagcaacac caaggtggac aagagagttg agtccaaata tggtccccca      720

tgcccaccat gcccagcacc tgagttcctg gggggaccat cagtcttcct gttcccccca      780

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      840

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      900

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      960

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac     1020

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag     1080

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg     1140

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg     1200

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1260

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     1320

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg     1380

ggtaaatga                                                             1389


<210>  26
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DOMAIN
<222>  (1)..(443)
<223>  heavy chain polypeptide

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             


<210>  27
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct encoding SEQ ID NO:26

<400>  27
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata cgccttcact tattacttga tagagtgggt gagacaggcc      120

cctggacaag ggcttgagtg gatcggagtg attaatcctg gaagtggtgg tactaactac      180

aatgagaagt tcaagggcag agccacgatc accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt atttctgtgc gagaaactgg      300

atgaactttg actactgggg gcaagggacc acggtcaccg tctcctcagc ttccaccaag      360

ggcccatccg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagccgcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cgaagaccta cacctgcaat      600

gtagatcaca agcccagcaa caccaaggtg gacaagagag ttgagtccaa atatggtccc      660

ccatgcccac catgcccagc acctgagttc ctggggggac catcagtctt cctgttcccc      720

ccaaaaccca aggacactct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      780

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc      960

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa tgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     1320

ctgggtaaat ga                                                         1332


<210>  28
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light/heavy chain polypetide construct

<400>  28

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gln Val Gln Leu Val 
    210                 215                 220                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
225                 230                 235                 240 


Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr Leu Ile Glu Trp Val 
                245                 250                 255     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asn Pro 
            260                 265                 270         


Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys Gly Arg Ala Thr 
        275                 280                 285             


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    290                 295                 300                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Asn Trp Met 
305                 310                 315                 320 


Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
                325                 330                 335     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
            340                 345                 350         


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        355                 360                 365             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    370                 375                 380                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
385                 390                 395                 400 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
                405                 410                 415     


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
            420                 425                 430         


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
        435                 440                 445             


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    450                 455                 460                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
465                 470                 475                 480 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
                485                 490                 495     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
            500                 505                 510         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        515                 520                 525             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    530                 535                 540                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
545                 550                 555                 560 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
                565                 570                 575     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            580                 585                 590         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        595                 600                 605             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
    610                 615                 620                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
625                 630                 635                 640 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                645                 650                 655     


Ser Leu Ser Leu Gly Lys 
            660         


<210>  29
<211>  1324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light/heavy chain polypeptide construct

<400>  29

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gln Val Gln Leu Val 
    210                 215                 220                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
225                 230                 235                 240 


Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr Leu Ile Glu Trp Val 
                245                 250                 255     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asn Pro 
            260                 265                 270         


Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys Gly Arg Ala Thr 
        275                 280                 285             


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    290                 295                 300                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Asn Trp Met 
305                 310                 315                 320 


Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
                325                 330                 335     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
            340                 345                 350         


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        355                 360                 365             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    370                 375                 380                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
385                 390                 395                 400 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
                405                 410                 415     


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
            420                 425                 430         


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
        435                 440                 445             


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    450                 455                 460                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
465                 470                 475                 480 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
                485                 490                 495     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
            500                 505                 510         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        515                 520                 525             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    530                 535                 540                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
545                 550                 555                 560 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
                565                 570                 575     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            580                 585                 590         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        595                 600                 605             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
    610                 615                 620                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
625                 630                 635                 640 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                645                 650                 655     


Ser Leu Ser Leu Gly Lys Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
            660                 665                 670         


Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser 
        675                 680                 685             


Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu 
    690                 695                 700                 


Gln Lys Pro Gly Gln Ser Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn 
705                 710                 715                 720 


Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                725                 730                 735     


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
            740                 745                 750         


Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly 
        755                 760                 765             


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    770                 775                 780                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
785                 790                 795                 800 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                805                 810                 815     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            820                 825                 830         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        835                 840                 845             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    850                 855                 860                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
865                 870                 875                 880 


Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
                885                 890                 895     


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr 
            900                 905                 910         


Tyr Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        915                 920                 925             


Ile Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys 
    930                 935                 940                 


Phe Lys Gly Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
945                 950                 955                 960 


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe 
                965                 970                 975     


Cys Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            980                 985                 990         


Val Thr Val Ser Ser Ala Ser Thr  Lys Gly Pro Ser Val  Phe Pro Leu 
        995                 1000                 1005             


Ala Pro  Cys Ser Arg Ser Thr  Ser Glu Ser Thr Ala  Ala Leu Gly 
    1010                 1015                 1020             


Cys Leu  Val Lys Asp Tyr Phe  Pro Glu Pro Val Thr  Val Ser Trp 
    1025                 1030                 1035             


Asn Ser  Gly Ala Leu Thr Ser  Gly Val His Thr Phe  Pro Ala Val 
    1040                 1045                 1050             


Leu Gln  Ser Ser Gly Leu Tyr  Ser Leu Ser Ser Val  Val Thr Val 
    1055                 1060                 1065             


Pro Ser  Ser Ser Leu Gly Thr  Lys Thr Tyr Thr Cys  Asn Val Asp 
    1070                 1075                 1080             


His Lys  Pro Ser Asn Thr Lys  Val Asp Lys Arg Val  Glu Ser Lys 
    1085                 1090                 1095             


Tyr Gly  Pro Pro Cys Pro Pro  Cys Pro Ala Pro Glu  Phe Leu Gly 
    1100                 1105                 1110             


Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 
    1115                 1120                 1125             


Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 
    1130                 1135                 1140             


Ser Gln  Glu Asp Pro Glu Val  Gln Phe Asn Trp Tyr  Val Asp Gly 
    1145                 1150                 1155             


Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Phe 
    1160                 1165                 1170             


Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 
    1175                 1180                 1185             


Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 
    1190                 1195                 1200             


Gly Leu  Pro Ser Ser Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 
    1205                 1210                 1215             


Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Gln Glu 
    1220                 1225                 1230             


Glu Met  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 
    1235                 1240                 1245             


Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 
    1250                 1255                 1260             


Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 
    1265                 1270                 1275             


Gly Ser  Phe Phe Leu Tyr Ser  Arg Leu Thr Val Asp  Lys Ser Arg 
    1280                 1285                 1290             


Trp Gln  Glu Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 
    1295                 1300                 1305             


Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Leu Gly 
    1310                 1315                 1320             


Lys 
    


<210>  30
<211>  327
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CHAIN
<222>  (1)..(327)
<223>  IgG4 heavy chain constant region polypeptide

<400>  30

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


