                         SEQUENCE LISTING

<110>  Sanford Health
       Roux, Kyle
 
<120>  Methods And Reagents For Identifying Proximate Proteins

<130>  12-1052-PCT

<150>  61/722145
<151>  2012-11-03

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  321
<212>  PRT
<213>  E. Coli

<400>  1

Met Lys Asp Asn Thr Val Pro Leu Lys Leu Ile Ala Leu Leu Ala Asn 
1               5                   10                  15      


Gly Glu Phe His Ser Gly Glu Gln Leu Gly Glu Thr Leu Gly Met Ser 
            20                  25                  30          


Arg Ala Ala Ile Asn Lys His Ile Gln Thr Leu Arg Asp Trp Gly Val 
        35                  40                  45              


Asp Val Phe Thr Val Pro Gly Lys Gly Tyr Ser Leu Pro Glu Pro Ile 
    50                  55                  60                  


Gln Leu Leu Asn Ala Lys Gln Ile Leu Gly Gln Leu Asp Gly Gly Ser 
65                  70                  75                  80  


Val Ala Val Leu Pro Val Ile Asp Ser Thr Asn Gln Tyr Leu Leu Asp 
                85                  90                  95      


Arg Ile Gly Glu Leu Lys Ser Gly Asp Ala Cys Ile Ala Glu Tyr Gln 
            100                 105                 110         


Gln Ala Gly Arg Gly Gly Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly 
        115                 120                 125             


Ala Asn Leu Tyr Leu Ser Met Phe Trp Arg Leu Glu Gln Gly Pro Ala 
    130                 135                 140                 


Ala Ala Ile Gly Leu Ser Leu Val Ile Gly Ile Val Met Ala Glu Val 
145                 150                 155                 160 


Leu Arg Lys Leu Gly Ala Asp Lys Val Arg Val Lys Trp Pro Asn Asp 
                165                 170                 175     


Leu Tyr Leu Gln Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Leu Thr 
            180                 185                 190         


Gly Lys Thr Gly Asp Ala Ala Gln Ile Val Ile Gly Ala Gly Ile Asn 
        195                 200                 205             


Met Ala Met Arg Arg Val Glu Glu Ser Val Val Asn Gln Gly Trp Ile 
    210                 215                 220                 


Thr Leu Gln Glu Ala Gly Ile Asn Leu Asp Arg Asn Thr Leu Ala Ala 
225                 230                 235                 240 


Met Leu Ile Arg Glu Leu Arg Ala Ala Leu Glu Leu Phe Glu Gln Glu 
                245                 250                 255     


Gly Leu Ala Pro Tyr Leu Ser Arg Trp Glu Lys Leu Asp Asn Phe Ile 
            260                 265                 270         


Asn Arg Pro Val Lys Leu Ile Ile Gly Asp Lys Glu Ile Phe Gly Ile 
        275                 280                 285             


Ser Arg Gly Ile Asp Lys Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly 
    290                 295                 300                 


Ile Ile Lys Pro Trp Met Gly Gly Glu Ile Ser Leu Arg Ser Ala Glu 
305                 310                 315                 320 


Lys 
    


<210>  2
<211>  233
<212>  PRT
<213>  A. aeolicus

<400>  2

Met Phe Lys Asn Leu Ile Trp Leu Lys Glu Val Asp Ser Thr Gln Glu 
1               5                   10                  15      


Arg Leu Lys Glu Trp Asn Val Ser Tyr Gly Thr Ala Leu Val Ala Asp 
            20                  25                  30          


Arg Gln Thr Lys Gly Arg Gly Gly Leu Gly Arg Lys Trp Leu Ser Gln 
        35                  40                  45              


Glu Gly Gly Leu Tyr Phe Ser Phe Leu Leu Asn Pro Lys Glu Phe Glu 
    50                  55                  60                  


Asn Leu Leu Gln Leu Pro Leu Val Leu Gly Leu Ser Val Ser Glu Ala 
65                  70                  75                  80  


Leu Glu Glu Ile Thr Glu Ile Pro Phe Ser Leu Lys Trp Pro Asn Asp 
                85                  90                  95      


Val Tyr Phe Gln Glu Lys Lys Val Ser Gly Val Leu Cys Glu Leu Ser 
            100                 105                 110         


Lys Asp Lys Leu Ile Val Gly Ile Gly Ile Asn Val Asn Gln Arg Glu 
        115                 120                 125             


Ile Pro Glu Glu Ile Lys Asp Arg Ala Thr Thr Leu Tyr Glu Ile Thr 
    130                 135                 140                 


Gly Lys Asp Trp Asp Arg Lys Glu Val Leu Leu Lys Val Leu Lys Arg 
145                 150                 155                 160 


Ile Ser Glu Asn Leu Lys Lys Phe Lys Glu Lys Ser Phe Lys Glu Phe 
                165                 170                 175     


Lys Gly Lys Ile Glu Ser Lys Met Leu Tyr Leu Gly Glu Glu Val Lys 
            180                 185                 190         


Leu Leu Gly Glu Gly Lys Ile Thr Gly Lys Leu Val Gly Leu Ser Glu 
        195                 200                 205             


Lys Gly Gly Ala Leu Ile Leu Thr Glu Glu Gly Ile Lys Glu Ile Leu 
    210                 215                 220                 


Ser Gly Glu Phe Ser Leu Arg Arg Ser 
225                 230             


<210>  3
<211>  243
<212>  PRT
<213>  H. influenzae

<400>  3

Met Met Asn Phe Thr Leu Leu Thr Tyr Leu Ala Asp Cys Gln Pro Lys 
1               5                   10                  15      


Val Arg Ser Glu Leu Glu Lys Phe Ser Lys Asn Leu Glu Glu Asp Ile 
            20                  25                  30          


Gln Gln Leu Arg Glu Ile Gly Leu Asp Ile Leu Val Asp Gly Gln Asp 
        35                  40                  45              


Tyr Arg Leu Val Pro Met Leu Pro Leu Leu Asn Pro Gln Gln Ile Ser 
    50                  55                  60                  


Thr Ala Leu Phe Pro Tyr Ser Ile His Tyr Gln Pro Ile Ile Ser Ser 
65                  70                  75                  80  


Thr Asn Glu Trp Ile Leu Gln Asn Ile Leu Ser Leu Lys Lys Gly Asp 
                85                  90                  95      


Leu Cys Val Ala Glu Tyr Gln Thr Ala Gly Arg Gly Gly Arg Gly Arg 
            100                 105                 110         


Gln Trp Leu Ser Pro Phe Ala Gly Gln Ile Met Phe Ser Phe Tyr Trp 
        115                 120                 125             


Ala Phe Asp Pro Lys Lys Ser Ile Glu Gly Leu Ser Leu Val Ile Gly 
    130                 135                 140                 


Leu Ala Ile Ala Glu Val Leu Asn Val Gln Val Lys Trp Pro Asn Asp 
145                 150                 155                 160 


Ile Leu Phe Asp Glu Arg Lys Leu Gly Gly Ile Leu Val Glu Ile Ala 
                165                 170                 175     


Asn His Lys Asn Gly Met Leu Asn Leu Val Ile Gly Ile Gly Ile Asn 
            180                 185                 190         


Val Ser Leu Ser Lys Gln Thr Glu Ile Ser Gln Pro Tyr Ala Glu Val 
        195                 200                 205             


Cys Glu Ile Asp Pro Asp Val Glu Arg Gln Thr Leu Leu Pro Lys Leu 
    210                 215                 220                 


Ile Gln His Leu Tyr Thr Arg Leu Asn Ile Phe Glu Gln Asn Gly Ile 
225                 230                 235                 240 


Asp Glu Glu 
            


<210>  4
<211>  320
<212>  PRT
<213>  S. typhimurium

<400>  4

Met Lys Asp Thr Thr Val Pro Leu Thr Leu Ile Ser Leu Leu Ala Asp 
1               5                   10                  15      


Gly Glu Phe His Ser Gly Glu Gln Leu Gly Glu Arg Leu Gly Met Ser 
            20                  25                  30          


Arg Ala Ala Ile Asn Lys His Ile Gln Thr Leu Arg Asp Trp Gly Val 
        35                  40                  45              


Asp Val Phe Thr Val Pro Gly Lys Gly Tyr Ser Leu Pro Glu Pro Ile 
    50                  55                  60                  


Gln Leu Leu Asp Ala Asp Arg Ile His Ser Gln Leu Asp Ser Gly Asn 
65                  70                  75                  80  


Val Ala Val Leu Pro Val Ile Asp Ser Thr Asn Gln Tyr Leu Leu Asp 
                85                  90                  95      


Arg Ile Gly Glu Leu Arg Ser Gly Asp Ala Cys Val Ala Glu Tyr Gln 
            100                 105                 110         


Gln Ala Gly Arg Gly Gly Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly 
        115                 120                 125             


Ala Asn Leu Tyr Leu Ser Met Tyr Trp Arg Leu Glu Gln Gly Pro Ala 
    130                 135                 140                 


Ala Ala Ile Gly Leu Ser Leu Val Ile Gly Ile Val Met Ala Glu Val 
145                 150                 155                 160 


Leu Arg Lys Leu Gly Ala Asp Lys Val Arg Val Lys Trp Pro Asn Asp 
                165                 170                 175     


Leu Tyr Leu Leu Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Leu Thr 
            180                 185                 190         


Gly Lys Thr Gly Asp Ala Ala Gln Ile Val Ile Gly Ala Gly Ile Asn 
        195                 200                 205             


Met Ala Met Arg Arg Val Glu Glu Asp Val Ile Asn Gln Gly Trp Ile 
    210                 215                 220                 


Thr Leu Gln Glu Ala Gly Ile Thr Leu Asp Arg Asn Met Leu Ala Ala 
225                 230                 235                 240 


Lys Leu Ile Tyr Lys Leu Arg Ala Ala Leu Glu Leu Phe Glu Gln Glu 
                245                 250                 255     


Gly Leu Ser Pro Tyr Leu Ser Arg Trp Lys Lys Leu Asp Asn Phe Ile 
            260                 265                 270         


Asp Arg Pro Val Lys Leu Ile Ile Gly Asp Lys Glu Ile Phe Gly Ile 
        275                 280                 285             


Ser Arg Gly Ile Asp Thr Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly 
    290                 295                 300                 


Val Ile Lys Pro Trp Met Gly Gly Glu Ile Ser Leu Arg Ser Ala Glu 
305                 310                 315                 320 


<210>  5

<400>  5
000

<210>  6
<211>  240
<212>  PRT
<213>  P. denitrificans

<400>  6

Met Leu Ala Arg Thr Asp Ser Thr Asn Ala Glu Ala Leu Lys Leu Ala 
1               5                   10                  15      


Pro Gly Leu Ser Gly Ser Ala Trp Val Leu Ala Arg Glu Gln Phe Ala 
            20                  25                  30          


Gly Arg Gly Gly Arg Gly Arg Glu Trp Val Met Pro Ala Gly Asn Phe 
        35                  40                  45              


Ala Gly Thr Leu Val Leu Arg Pro Gln Gly Gly Ala Leu Ala Ala Ala 
    50                  55                  60                  


Gln Leu Ser Phe Val Ala Ala Leu Ala Leu Tyr Asp Ala Leu Gly Leu 
65                  70                  75                  80  


Ala Cys Gly Pro Ala Ala Arg Leu Ala Ile Lys Trp Pro Asn Asp Val 
                85                  90                  95      


Leu Leu Asn Gly Gly Lys Val Ala Gly Ile Leu Leu Glu Ser Ser Gly 
            100                 105                 110         


Ser Gly Pro Gly Val Gln Ala Val Ala Val Gly Ile Gly Val Asn Leu 
        115                 120                 125             


Ala Gly Ala Pro Asp Ala Gly Ala Val Glu Pro Gly Ala Thr Pro Pro 
    130                 135                 140                 


Val Ser Val Gln Gly Glu Thr Gly His Ala Val Asp Pro Glu Glu Phe 
145                 150                 155                 160 


Leu Asp Leu Leu Ala Pro Ala Phe Ala Arg Trp Gln Ala Gln Leu Asp 
                165                 170                 175     


Thr Tyr Gly Phe Ala Pro Ile Arg Asn Ala Trp Leu Ala Arg Ala Ala 
            180                 185                 190         


Arg Leu Gly Glu Pro Ile Ile Ala Arg Thr Gly Thr Ala Glu Ser His 
        195                 200                 205             


Gly Ile Phe Glu Gly Ile Asp Asp Ser Gly Ala Leu Ile Leu Arg Gly 
    210                 215                 220                 


Pro Ala Gly Arg Gln Val Ile Pro Ala Ala Glu Val Phe Phe Gly Gly 
225                 230                 235                 240 


<210>  7
<211>  237
<212>  PRT
<213>  M. jannaschii

<400>  7

Met Glu Ile Ile His Leu Ser Glu Ile Asp Ser Thr Asn Asp Tyr Ala 
1               5                   10                  15      


Lys Glu Leu Ala Lys Glu Gly Lys Arg Asn Phe Ile Val Leu Ala Asp 
            20                  25                  30          


Lys Gln Asn Asn Gly Lys Gly Arg Trp Gly Arg Val Trp Tyr Ser Asp 
        35                  40                  45              


Glu Gly Gly Leu Tyr Phe Ser Met Val Leu Asp Ser Lys Leu Tyr Asn 
    50                  55                  60                  


Pro Lys Val Ile Asn Leu Leu Val Pro Ile Cys Ile Ile Glu Val Leu 
65                  70                  75                  80  


Lys Asn Tyr Val Asp Lys Glu Leu Gly Leu Lys Phe Pro Asn Asp Ile 
                85                  90                  95      


Met Val Lys Val Asn Asp Asn Tyr Lys Lys Leu Gly Gly Ile Leu Thr 
            100                 105                 110         


Glu Leu Thr Asp Asp Tyr Met Ile Ile Gly Ile Gly Ile Asn Val Asn 
        115                 120                 125             


Asn Gln Ile Arg Asn Glu Ile Arg Glu Ile Ala Ile Ser Leu Lys Glu 
    130                 135                 140                 


Ile Thr Gly Lys Glu Leu Asp Lys Val Glu Ile Leu Ser Asn Phe Leu 
145                 150                 155                 160 


Lys Thr Phe Glu Ser Tyr Leu Glu Lys Leu Lys Asn Lys Glu Ile Asp 
                165                 170                 175     


Asp Tyr Glu Ile Leu Lys Lys Tyr Lys Lys Tyr Ser Ile Thr Ile Gly 
            180                 185                 190         


Lys Gln Val Lys Ile Leu Leu Ser Asn Asn Glu Ile Ile Thr Gly Lys 
        195                 200                 205             


Val Tyr Asp Ile Asp Phe Asp Gly Ile Val Leu Gly Thr Glu Lys Gly 
    210                 215                 220                 


Ile Glu Arg Ile Pro Ser Gly Ile Cys Ile His Val Arg 
225                 230                 235         


<210>  8
<211>  631
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  8

Met Asn Val Leu Ile Tyr Asn Gly Asn Gly Ala Ser Lys Ile Cys Leu 
1               5                   10                  15      


Leu Arg Thr Phe Gln Ser Leu Leu Pro Phe Val Val Pro Leu Tyr Ala 
            20                  25                  30          


Met Arg Phe Val Asp Ala Ser Thr Leu Glu Lys Glu Pro Trp Pro Ala 
        35                  40                  45              


Ser Thr Ala Leu Leu Val Met Pro Gly Gly Arg Asp Met Gly Tyr Cys 
    50                  55                  60                  


Ser Ser Phe Asn Glu Thr Ile Tyr Arg Lys Ile Thr Asp Phe Val Lys 
65                  70                  75                  80  


Arg Gly Gly Ala Tyr Leu Gly Leu Cys Ala Gly Gly Tyr Phe Gly Ser 
                85                  90                  95      


Ala Val Val Asp Phe Arg Met Pro Asp Ser Asp Leu Asn Val Val Gly 
            100                 105                 110         


Lys Arg Lys Leu Gln Phe Phe Pro Gly Thr Cys Ala Gly Pro Thr Phe 
        115                 120                 125             


Pro Gly Phe Thr Tyr Asp Ser Glu Asp Gly Ala Arg Arg Ala Ser Ile 
    130                 135                 140                 


Ile Val Asp Gly Met Gln Ser Ser Pro Val His Thr His Ile Tyr Phe 
145                 150                 155                 160 


Asn Gly Gly Gly Ser Phe Leu Glu Thr Glu Asn Tyr Ser Asn Val Lys 
                165                 170                 175     


Val Val Ala Arg Tyr Gln Glu Thr Asp Phe Glu Lys Ser Ala Ala Ile 
            180                 185                 190         


Ile Tyr Val Lys Val Gly Lys Gly Asn Val Val Leu Thr Gly Ile His 
        195                 200                 205             


Pro Glu Phe Ser Ala Glu Gly Ser Pro Ile Leu Asp Lys Arg Asp Glu 
    210                 215                 220                 


Lys Thr Arg Leu Glu Leu Leu Ser Tyr Ile Leu Lys Leu Leu Gly Leu 
225                 230                 235                 240 


Lys Val Pro Lys Asp Thr Ser Lys Cys Gly Gln Pro Thr Leu Thr Asp 
                245                 250                 255     


Gln Tyr Leu Phe Pro Asn Asn Val Glu Thr Lys Arg Phe Ile Glu Lys 
            260                 265                 270         


Ala Leu Thr Asn Lys Val Lys Asn Gln Asp Glu Asp Thr Leu Tyr Thr 
        275                 280                 285             


Phe Gln Phe Ser Asp Ile Ser Ser Glu Ile Pro Glu His Gln Leu Ala 
    290                 295                 300                 


Asn Leu Asp Ile Ser Ala Asp Leu Ser Asp Ser Asp Asn Glu Ile Val 
305                 310                 315                 320 


Lys Ile Trp Tyr Gly Asp Glu Glu Lys Ile Cys Lys Lys Ala Lys Pro 
                325                 330                 335     


Ser Phe Asp Leu Glu Leu Tyr Ala Lys Leu Ile Asn Gly Cys Arg Phe 
            340                 345                 350         


Gly Leu Pro Ile Ile Val Ala Pro Val Ile Arg Ser Thr Gln Thr Leu 
        355                 360                 365             


Leu Asp Lys Asn Tyr Arg Phe Leu Asp Ser Thr Asn Thr Gly Phe Thr 
    370                 375                 380                 


Val Leu Gly Asn Tyr Gln Thr Ala Gly Arg Gly Gly Gly Gln Asn Met 
385                 390                 395                 400 


Trp Val Ser Pro Tyr Gly Thr Leu Ala Phe Ser Phe Ile Ile Asn Val 
                405                 410                 415     


Asp Ala Lys Asn Phe Ser Thr Thr Pro Ile Ala Leu Phe Gln Tyr Leu 
            420                 425                 430         


Met Ala Leu Ala Val Val Arg Gly Ile Arg Glu Tyr Ala Pro Gly Tyr 
        435                 440                 445             


Glu Asn Ile Pro Ala Phe Ile Lys Trp Pro Asn Asp Val Tyr Val Arg 
    450                 455                 460                 


Val Asp Lys Gly Gly Ile Asn Phe Gln Gly Lys Gln Tyr Met Lys Leu 
465                 470                 475                 480 


Ser Gly Ile Ile Val Thr Ser Asn Tyr Arg Lys Asn Val Leu His Leu 
                485                 490                 495     


Val Val Gly Cys Gly Ile Asn Val Ser Asn Leu Gly Pro Thr Val Ser 
            500                 505                 510         


Leu Asn Thr Leu Val Asp Glu Trp Asn Lys Asn Ser Asp Asn Pro Arg 
        515                 520                 525             


Leu Glu Lys Phe Ser Phe Glu Lys Leu Leu Ala Ser Val Leu Asn Gln 
    530                 535                 540                 


Phe Asp Arg Tyr His Arg Leu Leu Leu Glu Glu Gly Phe Ser Leu Ile 
545                 550                 555                 560 


Leu Pro Glu Tyr Tyr Gln Tyr Trp Leu His Ser Asn Gln Thr Val Asn 
                565                 570                 575     


Leu Ala Ser Gly Gly Lys Ala Ile Ile Gln Gly Ile Thr Ser Asp Phe 
            580                 585                 590         


Gly Phe Leu Leu Ala Gln Leu Leu Asn Glu Asn Asn Glu Pro Thr Thr 
        595                 600                 605             


Lys Val Val His Leu Gln Pro Asp Gly Asn Ser Phe Asp Leu Met Arg 
    610                 615                 620                 


Asn Leu Ile Thr Arg Lys Thr 
625                 630     


<210>  9
<211>  690
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Asn Val Leu Val Tyr Asn Gly Pro Gly Thr Thr Pro Gly Ser Val 
1               5                   10                  15      


Lys His Ala Val Glu Ser Leu Arg Asp Phe Leu Glu Pro Tyr Tyr Ala 
            20                  25                  30          


Val Ser Thr Val Asn Val Lys Val Leu Gln Thr Glu Pro Trp Met Ser 
        35                  40                  45              


Lys Thr Ser Ala Val Val Phe Pro Gly Gly Ala Asp Leu Pro Tyr Val 
    50                  55                  60                  


Gln Ala Cys Gln Pro Ile Ile Ser Arg Leu Lys His Phe Val Ser Lys 
65                  70                  75                  80  


Gln Gly Gly Val Phe Ile Gly Phe Cys Ala Gly Gly Tyr Phe Gly Thr 
                85                  90                  95      


Ser Arg Val Glu Phe Ala Gln Gly Asp Pro Thr Met Glu Val Ser Gly 
            100                 105                 110         


Ser Arg Asp Leu Arg Phe Phe Pro Gly Thr Ser Arg Gly Pro Ala Tyr 
        115                 120                 125             


Asn Gly Phe Gln Tyr Asn Ser Glu Ala Gly Ala Arg Ala Val Lys Leu 
    130                 135                 140                 


Asn Leu Pro Asp Gly Ser Gln Phe Ser Thr Tyr Phe Asn Gly Gly Ala 
145                 150                 155                 160 


Val Phe Val Asp Ala Asp Lys Phe Asp Asn Val Glu Ile Leu Ala Thr 
                165                 170                 175     


Tyr Ala Glu His Pro Asp Val Pro Ser Ser Asp Ser Gly Lys Gly Gln 
            180                 185                 190         


Ser Glu Asn Pro Ala Ala Val Val Leu Cys Thr Val Gly Arg Gly Lys 
        195                 200                 205             


Val Leu Leu Thr Gly Pro His Pro Glu Phe Asn Val Arg Phe Met Arg 
    210                 215                 220                 


Lys Ser Thr Asp Lys His Phe Leu Glu Thr Val Val Glu Asn Leu Lys 
225                 230                 235                 240 


Ala Gln Glu Ile Met Arg Leu Lys Phe Met Arg Thr Val Leu Thr Lys 
                245                 250                 255     


Thr Gly Leu Asn Cys Asn Asn Asp Phe Asn Tyr Val Arg Ala Pro Asn 
            260                 265                 270         


Leu Thr Pro Leu Phe Met Ala Ser Ala Pro Asn Lys Arg Asn Tyr Leu 
        275                 280                 285             


Gln Glu Met Glu Asn Asn Leu Ala His His Gly Met His Ala Asn Asn 
    290                 295                 300                 


Val Glu Leu Cys Ser Glu Leu Asn Ala Glu Thr Asp Ser Phe Gln Phe 
305                 310                 315                 320 


Tyr Arg Gly Tyr Arg Ala Ser Tyr Asp Ala Ala Ser Ser Ser Leu Leu 
                325                 330                 335     


His Lys Glu Pro Asp Glu Val Pro Lys Thr Val Ile Phe Pro Gly Val 
            340                 345                 350         


Asp Glu Asp Ile Pro Pro Phe Gln Tyr Thr Pro Asn Phe Asp Met Lys 
        355                 360                 365             


Glu Tyr Phe Lys Tyr Leu Asn Val Gln Asn Thr Ile Gly Ser Leu Leu 
    370                 375                 380                 


Leu Tyr Gly Glu Val Val Thr Ser Thr Ser Thr Ile Leu Asn Asn Asn 
385                 390                 395                 400 


Lys Ser Leu Leu Ser Ser Ile Pro Glu Ser Thr Leu Leu His Val Gly 
                405                 410                 415     


Thr Ile Gln Val Ser Gly Arg Gly Gly Gly Gly Asn Thr Trp Ile Asn 
            420                 425                 430         


Pro Lys Gly Val Cys Ala Ser Thr Ala Val Val Thr Met Pro Leu Gln 
        435                 440                 445             


Ser Pro Val Thr Asn Arg Asn Ile Ser Val Val Phe Val Gln Tyr Leu 
    450                 455                 460                 


Ser Met Leu Ala Tyr Cys Lys Ala Ile Leu Ser Tyr Ala Pro Gly Phe 
465                 470                 475                 480 


Ser Asp Ile Pro Val Arg Ile Lys Trp Pro Asn Asp Leu Tyr Ala Leu 
                485                 490                 495     


Ser Pro Thr Tyr Tyr Lys Arg Lys Asn Leu Lys Leu Val Asn Thr Gly 
            500                 505                 510         


Phe Glu His Thr Lys Leu Pro Leu Gly Asp Ile Glu Pro Ala Tyr Leu 
        515                 520                 525             


Lys Ile Ser Gly Leu Leu Val Asn Thr His Phe Ile Asn Asn Lys Tyr 
    530                 535                 540                 


Cys Leu Leu Leu Gly Cys Gly Ile Asn Leu Thr Ser Asp Gly Pro Thr 
545                 550                 555                 560 


Thr Ser Leu Gln Thr Trp Ile Asp Ile Leu Asn Glu Glu Arg Gln Gln 
                565                 570                 575     


Leu His Leu Asp Leu Leu Pro Ala Ile Lys Ala Glu Lys Leu Gln Ala 
            580                 585                 590         


Leu Tyr Met Asn Asn Leu Glu Val Ile Leu Lys Gln Phe Ile Asn Tyr 
        595                 600                 605             


Gly Ala Ala Glu Ile Leu Pro Ser Tyr Tyr Glu Leu Trp Leu His Ser 
    610                 615                 620                 


Asn Gln Ile Val Thr Leu Pro Asp His Gly Asn Thr Gln Ala Met Ile 
625                 630                 635                 640 


Thr Gly Ile Thr Glu Asp Tyr Gly Leu Leu Ile Ala Lys Glu Leu Val 
                645                 650                 655     


Ser Gly Ser Ser Thr Gln Phe Thr Gly Asn Val Tyr Asn Leu Gln Pro 
            660                 665                 670         


Asp Gly Asn Thr Phe Asp Ile Phe Lys Ser Leu Ile Ala Lys Lys Val 
        675                 680                 685             


Gln Ser 
    690 


<210>  10
<211>  723
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Glu Asp Arg Leu Gln Met Asp Asn Gly Leu Ile Ala Gln Lys Ile 
1               5                   10                  15      


Val Ser Val His Leu Lys Asp Pro Ala Leu Lys Glu Leu Ser Lys Ala 
            20                  25                  30          


Ser Asn Lys Gln Val Gln Ala Pro Leu Pro Ser Pro Glu Ala Ser Leu 
        35                  40                  45              


Glu Ala Gln Pro Ala Gln Gly Val Met Glu Gln Ala Gly Gln Gly Asp 
    50                  55                  60                  


Trp Lys Ala Ala Gly Glu Gly Pro Ser Pro Gln Arg Arg Gly Cys Ala 
65                  70                  75                  80  


Pro Val Ser Glu Ser Ala Ala Asp Gly Asp Pro Gly Gln Gly Ser Thr 
                85                  90                  95      


Glu Leu Cys Gln Leu His Leu Ser Ser Cys His Glu Cys Leu Glu Leu 
            100                 105                 110         


Glu Asn Ser Thr Ile Glu Ser Val Arg Cys Ala Ser Ala Glu Asn Ile 
        115                 120                 125             


Pro Asp Leu Pro His Asp Cys Ser Ser Ser Val Glu Gly Thr Ala Gly 
    130                 135                 140                 


Glu Leu Cys Pro Glu Arg Lys Gly Lys Arg Val Asn Ile Ser Gly Lys 
145                 150                 155                 160 


Ala Pro Asn Ile Leu Leu Tyr Val Gly Ser Gly Ser Glu Glu Ala Leu 
                165                 170                 175     


Gly Gln Leu Gln Gln Val Arg Ser Val Leu Thr Asp Cys Val Asp Thr 
            180                 185                 190         


Asp Ser Tyr Thr Leu Tyr His Leu Leu Glu Asp Ser Ala Leu Arg Asp 
        195                 200                 205             


Pro Trp Pro Asp Asn Cys Leu Leu Leu Val Ile Ala Ser Arg Asp Pro 
    210                 215                 220                 


Ile Pro Lys Gly Ile His His Arg Phe Met Ala Tyr Leu Ser Gln Gly 
225                 230                 235                 240 


Gly Lys Val Leu Gly Leu Ser Ser Ser Phe Thr Phe Gly Asp Leu Arg 
                245                 250                 255     


Val Ala Arg Arg Asp Val Leu Arg Asn Thr Ala Gln Asn Leu Val Phe 
            260                 265                 270         


Ser Lys Ala Asp Gly Ser Glu Val Arg Leu Ser Val Leu Ser Ser Gly 
        275                 280                 285             


Tyr Val Tyr Glu Glu Gly Pro Ser Leu Gly Arg Leu Gln Gly His Leu 
    290                 295                 300                 


Glu Asn Glu Asp Lys Asp Lys Met Ile Val His Val Pro Phe Gly Thr 
305                 310                 315                 320 


His Gly Gly Glu Ala Ile Leu Cys Gln Val His Leu Glu Leu Pro Pro 
                325                 330                 335     


Ser Ala Pro Leu Val Gln Thr Thr Asp Asp Phe Asn Val Leu Lys Ser 
            340                 345                 350         


Ser Asn Thr Arg Arg Leu Glu Val Leu Lys Glu Ile Leu Thr Ala Leu 
        355                 360                 365             


Gly Leu Ser Cys Asp Ala Pro Gln Ala Pro Ala Leu Thr Pro Leu Tyr 
    370                 375                 380                 


Leu Leu Leu Ala Ala Glu Glu Ile Gln Gly Pro Phe Met Gln Trp Leu 
385                 390                 395                 400 


Ala Arg His Val Asp Pro Glu Gly Val Ile Lys Ser Ser Lys Leu Ser 
                405                 410                 415     


Leu Lys Phe Val Ser Ser Tyr Thr Ser Glu Ala Glu Ile Thr Pro Ser 
            420                 425                 430         


Ser Ile Pro Val Val Thr Asp Pro Glu Gly Phe Ser Ser Glu His Phe 
        435                 440                 445             


Asn Leu Glu Thr Tyr Arg Gln Asn Leu Gln Ser Thr Arg Leu Gly Arg 
    450                 455                 460                 


Val Ile Leu Phe Ala Glu Val Thr Ser Thr Thr Met Ser Leu Leu Asp 
465                 470                 475                 480 


Gly Leu Met Phe Glu Met Pro Gln Glu Met Gly Leu Ile Ala Ile Ala 
                485                 490                 495     


Val Arg Gln Thr Gln Gly Lys Gly Gly Gly Pro Asn Ala Trp Leu Ser 
            500                 505                 510         


Pro Val Gly Cys Ala Leu Ser Thr Leu Leu Val Ser Ile Pro Leu Arg 
        515                 520                 525             


Ser Gln Leu Gly Gln Arg Ile Pro Phe Val Gln His Leu Met Ser Leu 
    530                 535                 540                 


Ala Val Val Glu Ala Val Arg Ser Ile Pro Glu Tyr Glu Asp Ile Asn 
545                 550                 555                 560 


Leu Arg Val Lys Trp Pro Asn Asp Ile Tyr Tyr Ser Asp Leu Met Lys 
                565                 570                 575     


Ile Gly Gly Val Leu Val Asn Ser Thr Leu Val Gly Glu Thr Phe Tyr 
            580                 585                 590         


Ile Leu Ile Gly Cys Gly Phe Asn Val Thr Asn Ser Asn Pro Thr Ile 
        595                 600                 605             


Cys Ile Asn Asp Leu Ile Glu Glu His Asn Lys Gln Asn Lys Ala Gly 
    610                 615                 620                 


Leu Lys Pro Leu Gln Ala Asp Cys Leu Ile Ala Arg Ala Val Thr Val 
625                 630                 635                 640 


Leu Glu Lys Leu Ile Asp Arg Phe Gln Asp Gln Gly Pro Asp Gly Val 
                645                 650                 655     


Leu Pro Leu Tyr Tyr Lys Tyr Trp Ala His Ser Gly Gln Gln Val Arg 
            660                 665                 670         


Leu Gly Ser Ser Glu Gly Pro Ala Val Ser Ile Val Gly Leu Asp Asp 
        675                 680                 685             


Ser Gly Phe Leu Gln Val His Gln Glu Gly Gly Gly Val Val Ser Val 
    690                 695                 700                 


His Pro Asp Gly Asn Ser Phe Asp Met Leu Arg Asn Leu Ile Val Pro 
705                 710                 715                 720 


Lys Arg Pro 
            


<210>  11
<211>  722
<212>  PRT
<213>  Mus musculus

<400>  11

Met Glu Asp Arg Leu Gln Met Asp Asn Gly Leu Ile Ala Gln Lys Ile 
1               5                   10                  15      


Val Ser Val His Leu Lys Asp Pro Ala Leu Lys Glu Leu Gly Lys Ala 
            20                  25                  30          


Ser Asp Lys Gln Val Gln Gly Pro Pro Pro Gly Pro Glu Ala Ser Pro 
        35                  40                  45              


Glu Ala Gln Pro Ala Gln Gly Val Met Glu His Ala Gly Gln Gly Asp 
    50                  55                  60                  


Cys Lys Ala Ala Gly Glu Gly Pro Ser Pro Arg Arg Arg Gly Cys Ala 
65                  70                  75                  80  


Pro Glu Ser Glu Pro Ala Ala Asp Gly Asp Pro Gly Leu Ser Ser Pro 
                85                  90                  95      


Glu Leu Cys Gln Leu His Leu Ser Ile Cys His Glu Cys Leu Glu Leu 
            100                 105                 110         


Glu Asn Ser Thr Ile Asp Ser Val Arg Ser Ala Ser Ala Glu Asn Ile 
        115                 120                 125             


Pro Asp Leu Pro Cys Asp His Ser Gly Val Glu Gly Ala Ala Gly Glu 
    130                 135                 140                 


Leu Cys Pro Glu Arg Lys Gly Lys Arg Val Asn Ile Ser Gly Lys Ala 
145                 150                 155                 160 


Pro Asn Ile Leu Leu Tyr Val Gly Ser Gly Ser Glu Glu Ala Leu Gly 
                165                 170                 175     


Arg Leu Gln Gln Val Arg Ser Val Leu Thr Asp Cys Val Asp Thr Asp 
            180                 185                 190         


Ser Tyr Thr Leu Tyr His Leu Leu Glu Asp Ser Ala Leu Arg Asp Pro 
        195                 200                 205             


Trp Ser Asp Asn Cys Leu Leu Leu Val Ile Ala Ser Arg Asp Pro Ile 
    210                 215                 220                 


Pro Lys Asp Ile Gln His Lys Phe Met Ala Tyr Leu Ser Gln Gly Gly 
225                 230                 235                 240 


Lys Val Leu Gly Leu Ser Ser Pro Phe Thr Leu Gly Gly Phe Arg Val 
                245                 250                 255     


Thr Arg Arg Asp Val Leu Arg Asn Thr Val Gln Asn Leu Val Phe Ser 
            260                 265                 270         


Lys Ala Asp Gly Thr Glu Val Arg Leu Ser Val Leu Ser Ser Gly Tyr 
        275                 280                 285             


Val Tyr Glu Glu Gly Pro Ser Leu Gly Arg Leu Gln Gly His Leu Glu 
    290                 295                 300                 


Asn Glu Asp Lys Asp Lys Met Ile Val His Val Pro Phe Gly Thr Leu 
305                 310                 315                 320 


Gly Gly Glu Ala Val Leu Cys Gln Val His Leu Glu Leu Pro Pro Gly 
                325                 330                 335     


Ala Ser Leu Val Gln Thr Ala Asp Asp Phe Asn Val Leu Lys Ser Ser 
            340                 345                 350         


Asn Val Arg Arg His Glu Val Leu Lys Glu Ile Leu Thr Ala Leu Gly 
        355                 360                 365             


Leu Ser Cys Asp Ala Pro Gln Val Pro Ala Leu Thr Pro Leu Tyr Leu 
    370                 375                 380                 


Leu Leu Ala Ala Glu Glu Thr Gln Asp Pro Phe Met Gln Trp Leu Gly 
385                 390                 395                 400 


Arg His Thr Asp Pro Glu Gly Ile Ile Lys Ser Ser Lys Leu Ser Leu 
                405                 410                 415     


Gln Phe Val Ser Ser Tyr Thr Ser Glu Ala Glu Ile Thr Pro Ser Ser 
            420                 425                 430         


Met Pro Val Val Thr Asp Pro Glu Ala Phe Ser Ser Glu His Phe Ser 
        435                 440                 445             


Leu Glu Thr Tyr Arg Gln Asn Leu Gln Thr Thr Arg Leu Gly Lys Val 
    450                 455                 460                 


Ile Leu Phe Ala Glu Val Thr Ser Thr Thr Met Ser Leu Leu Asp Gly 
465                 470                 475                 480 


Leu Met Phe Glu Met Pro Gln Glu Met Gly Leu Ile Ala Ile Ala Val 
                485                 490                 495     


Arg Gln Thr Gln Gly Lys Gly Gly Gly Pro Asn Ala Trp Leu Ser Pro 
            500                 505                 510         


Val Gly Cys Ala Leu Ser Thr Leu Leu Val Phe Ile Pro Leu Arg Ser 
        515                 520                 525             


Gln Leu Gly Gln Arg Ile Pro Phe Val Gln His Leu Met Ser Leu Ala 
    530                 535                 540                 


Val Val Glu Ala Val Arg Ser Ile Pro Gly Tyr Glu Asp Ile Asn Leu 
545                 550                 555                 560 


Arg Val Lys Trp Pro Asn Asp Ile Tyr Tyr Ser Asp Leu Met Lys Ile 
                565                 570                 575     


Gly Gly Val Leu Val Asn Ser Thr Leu Met Gly Glu Thr Phe Tyr Ile 
            580                 585                 590         


Leu Ile Gly Cys Gly Phe Asn Val Thr Asn Ser Asn Pro Thr Ile Cys 
        595                 600                 605             


Ile Asn Asp Leu Ile Glu Glu His Asn Lys Gln His Gly Ala Gly Leu 
    610                 615                 620                 


Lys Pro Leu Arg Ala Asp Cys Leu Ile Ala Arg Ala Val Thr Val Leu 
625                 630                 635                 640 


Glu Lys Leu Ile Asp Arg Phe Gln Asp Gln Gly Pro Asp Gly Val Leu 
                645                 650                 655     


Pro Leu Tyr Tyr Lys Tyr Trp Val His Gly Gly Gln Gln Val Arg Leu 
            660                 665                 670         


Gly Ser Thr Glu Gly Pro Gln Ala Ser Ile Val Gly Leu Asp Asp Ser 
        675                 680                 685             


Gly Phe Leu Gln Val His Gln Glu Asp Gly Gly Val Val Thr Val His 
    690                 695                 700                 


Pro Asp Gly Asn Ser Phe Asp Met Leu Arg Asn Leu Ile Val Pro Lys 
705                 710                 715                 720 


Arg Gln 
        


<210>  12
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Asp Arg Leu His Met Asp Asn Gly Leu Val Pro Gln Lys Ile 
1               5                   10                  15      


Val Ser Val His Leu Gln Asp Ser Thr Leu Lys Glu Val Lys Asp Gln 
            20                  25                  30          


Val Ser Asn Lys Gln Ala Gln Ile Leu Glu Pro Lys Pro Glu Pro Ser 
        35                  40                  45              


Leu Glu Ile Lys Pro Glu Gln Asp Gly Met Glu His Val Gly Arg Asp 
    50                  55                  60                  


Asp Pro Lys Ala Leu Gly Glu Glu Pro Lys Gln Arg Arg Gly Ser Ala 
65                  70                  75                  80  


Ser Gly Ser Glu Pro Ala Gly Asp Ser Asp Arg Gly Gly Gly Pro Val 
                85                  90                  95      


Glu His Tyr His Leu His Leu Ser Ser Cys His Glu Cys Leu Glu Leu 
            100                 105                 110         


Glu Asn Ser Thr Ile Glu Ser Val Lys Phe Ala Ser Ala Glu Asn Ile 
        115                 120                 125             


Pro Asp Leu Pro Tyr Asp Tyr Ser Ser Ser Leu Glu Ser Val Ala Asp 
    130                 135                 140                 


Glu Thr Ser Pro Glu Arg Glu Gly Arg Arg Val Asn Leu Thr Gly Lys 
145                 150                 155                 160 


Ala Pro Asn Ile Leu Leu Tyr Val Gly Ser Asp Ser Gln Glu Ala Leu 
                165                 170                 175     


Gly Arg Phe His Glu Val Arg Ser Val Leu Ala Asp Cys Val Asp Ile 
            180                 185                 190         


Asp Ser Tyr Ile Leu Tyr His Leu Leu Glu Asp Ser Ala Leu Arg Asp 
        195                 200                 205             


Pro Trp Thr Asp Asn Cys Leu Leu Leu Val Ile Ala Thr Arg Glu Ser 
    210                 215                 220                 


Ile Pro Glu Asp Leu Tyr Gln Lys Phe Met Ala Tyr Leu Ser Gln Gly 
225                 230                 235                 240 


Gly Lys Val Leu Gly Leu Ser Ser Ser Phe Thr Phe Gly Gly Phe Gln 
                245                 250                 255     


Val Thr Ser Lys Gly Ala Leu His Lys Thr Val Gln Asn Leu Val Phe 
            260                 265                 270         


Ser Lys Ala Asp Gln Ser Glu Val Lys Leu Ser Val Leu Ser Ser Gly 
        275                 280                 285             


Cys Arg Tyr Gln Glu Gly Pro Val Arg Leu Ser Pro Gly Arg Leu Gln 
    290                 295                 300                 


Gly His Leu Glu Asn Glu Asp Lys Asp Arg Met Ile Val His Val Pro 
305                 310                 315                 320 


Phe Gly Thr Arg Gly Gly Glu Ala Val Leu Cys Gln Val His Leu Glu 
                325                 330                 335     


Leu Pro Pro Ser Ser Asn Ile Val Gln Thr Pro Glu Asp Phe Asn Leu 
            340                 345                 350         


Leu Lys Ser Ser Asn Phe Arg Arg Tyr Glu Val Leu Arg Glu Ile Leu 
        355                 360                 365             


Thr Thr Leu Gly Leu Ser Cys Asp Met Lys Gln Val Pro Ala Leu Thr 
    370                 375                 380                 


Pro Leu Tyr Leu Leu Ser Ala Ala Glu Glu Ile Arg Asp Pro Leu Met 
385                 390                 395                 400 


Gln Trp Leu Gly Lys His Val Asp Ser Glu Gly Glu Ile Lys Ser Gly 
                405                 410                 415     


Gln Leu Ser Leu Arg Phe Val Ser Ser Tyr Val Ser Glu Val Glu Ile 
            420                 425                 430         


Thr Pro Ser Cys Ile Pro Val Val Thr Asn Met Glu Ala Phe Ser Ser 
        435                 440                 445             


Glu His Phe Asn Leu Glu Ile Tyr Arg Gln Asn Leu Gln Thr Lys Gln 
    450                 455                 460                 


Leu Gly Lys Val Ile Leu Phe Ala Glu Val Thr Pro Thr Thr Met Arg 
465                 470                 475                 480 


Leu Leu Asp Gly Leu Met Phe Gln Thr Pro Gln Glu Met Gly Leu Ile 
                485                 490                 495     


Val Ile Ala Ala Arg Gln Thr Glu Gly Lys Gly Gly Gly Gly Asn Val 
            500                 505                 510         


Trp Leu Ser Pro Val Gly Cys Ala Leu Ser Thr Leu Leu Ile Ser Ile 
        515                 520                 525             


Pro Leu Arg Ser Gln Leu Gly Gln Arg Ile Pro Phe Val Gln His Leu 
    530                 535                 540                 


Met Ser Val Ala Val Val Glu Ala Val Arg Ser Ile Pro Glu Tyr Gln 
545                 550                 555                 560 


Asp Ile Asn Leu Arg Val Lys Trp Pro Asn Asp Ile Tyr Tyr Ser Asp 
                565                 570                 575     


Leu Met Lys Ile Gly Gly Val Leu Val Asn Ser Thr Leu Met Gly Glu 
            580                 585                 590         


Thr Phe Tyr Ile Leu Ile Gly Cys Gly Phe Asn Val Thr Asn Ser Asn 
        595                 600                 605             


Pro Thr Ile Cys Ile Asn Asp Leu Ile Thr Glu Tyr Asn Lys Gln His 
    610                 615                 620                 


Lys Ala Glu Leu Lys Pro Leu Arg Ala Asp Tyr Leu Ile Ala Arg Val 
625                 630                 635                 640 


Val Thr Val Leu Glu Lys Leu Ile Lys Glu Phe Gln Asp Lys Gly Pro 
                645                 650                 655     


Asn Ser Val Leu Pro Leu Tyr Tyr Arg Tyr Trp Val His Ser Gly Gln 
            660                 665                 670         


Gln Val His Leu Gly Ser Ala Glu Gly Pro Lys Val Ser Ile Val Gly 
        675                 680                 685             


Leu Asp Asp Ser Gly Phe Leu Gln Val His Gln Glu Gly Gly Glu Val 
    690                 695                 700                 


Val Thr Val His Pro Asp Gly Asn Ser Phe Asp Met Leu Arg Asn Leu 
705                 710                 715                 720 


Ile Leu Pro Lys Arg Arg 
                725     


<210>  13
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is A, L, I, T, V, or is absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is C, L, V, H, A, or is absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is I, V, or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is E, D, R, T, N, V or A

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is Y, R, K, E, or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Q

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is Q, T, N, F, V, or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is A, K, N, S, Q, or E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is R or K

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is any residue other than R

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is R, L, W, G, or S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is G, Q, P, or K

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is R or N

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is K, Q, V, E, T, M, or A

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is W

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is F, L, Y, E, I, or V

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is S, M or N

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is P, Q or D

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is F, E, A, K, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is G or A

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is V, C or is absent

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is A, C or is absent

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is A, L or is absent

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is A, G, S or is absent

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X is N, G, Q, T, or C

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  X is L, I, A, or F

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is Y, M, A, V, or L

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is L, G, V, I, or F

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is S, T, or F

<400>  13

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  14
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is P, T, Q or absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is E, N or absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is S, T, M or absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is T, G or absent

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is T, F, L or absent

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is A, L, I, V, T or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is C, L, V, H, A or absent

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is I, V, or L

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is E, D, R, T, N, V, or A

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is Y, R, K, E or I

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is Q

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is T, S, Q, N, V or F

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is A, K, N, S, Q, or E

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is R or K

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is any amino acid othan than G

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is R, L W, G or S

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is G, K, Q or P

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is R or N

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is K, Q, V, E, T, M, or A

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is W

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is L, V, I, F, Y, or E

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is S, M or N

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is P, Q or D

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is F, E, A, K, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X is G or A

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  X is V, C or absent

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is A, C or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is A, L or absent

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is A, G, S or absent

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is N, G, Q, T or C

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is L, I, A or F

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  X is A, V, Y, L, or M

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  X is L, G, V, I or F

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  X is S, T or F

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X is M, F, L or I

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  X is F, L, Y, V, P, I or S

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is L, I, V or W

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X is R, N, A, D or Q

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X is L, P, F, S, V, or M

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is E, K, D, Q or P

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  X is L, G, V, A, Q, E, P or D

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  X is G, F, K, Y or T

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  X is N, R, Q, or absent

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  X is R, F, V, or absent

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is N, S or absent

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  X is T or absent

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  X is T, I or absent

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X is S, P or absent

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  X is V, I or absent

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  X is P, A, V, or absent

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  X is A, E, K, P, L or F

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X is A, V, L, N, S or K

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  X is A, V, L, I or Q

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  X is L, I, E, A, Y, H or absent

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  X is G, L, V, Q or absent

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  X is L, I, V, S or M

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  X is S, P, N, M or A

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  X is L, V or F

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  X is L, V or A

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  X is A, I, L, V or Y

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  X is G, P, A, C, U or T

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  X is I, L, V, K, R or E

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  X is V, A, G, S, C, or E

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  X is V, I, L, A or M

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  X is A, I, L, V, S, Y, R, or K

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  X is D, E, S or R

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  X is V, A, I, Y or S

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  X is L, A, I, or C

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is R, E, N, K, G, P or H

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  X is K, E, N, L, G, E or absent

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X is L, I, Y, A, L, F, K or absent

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X is G, T, V, S, C, E, Q or absent

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is A, E, D, G, N, L or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  X is P or absent

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  X is F, A or absent

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  X is I, A, L, D, K or absent

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  X is K, P, E, R, D, N or absent

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  X is V, L, A, or F

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  X is R, K, S, Q, G, A or F

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is V, L or I

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  X is K

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  X is W

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  X is P

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  X is N

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  X is D

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  X is L, I or V

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  X is Y, L or M

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  X is L, V, A, F, or Y

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  X is Q, D, K, N, L, R, or S

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X is D, E, V, G, or S

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  X is N, P, D, L or absent

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  X is T, K or absent

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  X is Y, G or absent

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  X is Y, G or absent

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  X is K or absent

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  X is R or absent

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  X is K or absent

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  X is N or absent

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  X is L or absent

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  X is K or absent

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  X is L or absent

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  X is V or absent

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  X is N or absent

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  X is T or absent

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  X is G or absent

<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  X is F or absent

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  X is E or absent

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  X is H or absent

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  X is T or absent

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  X is K or absent

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  X is L or absent

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  X is P or absent

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  X is I, L or absent

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  X is G, N or absent

<220>
<221>  MISC_FEATURE
<222>  (118)..(118)
<223>  X is D, F or absent

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X is I, Q or absent

<220>
<221>  MISC_FEATURE
<222>  (120)..(120)
<223>  X is E, G or absent

<220>
<221>  MISC_FEATURE
<222>  (121)..(121)
<223>  X is P, K, D or absent

<220>
<221>  MISC_FEATURE
<222>  (122)..(122)
<223>  X is N, A, Q or absent

<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  X is Y or absent

<220>
<221>  MISC_FEATURE
<222>  (124)..(124)
<223>  X is R, K, G, L or M

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  X is K

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  X is L, V, or I

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  X is A, G, or S

<220>
<221>  MISC_FEATURE
<222>  (128)..(128)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (129)..(129)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  X is I or L

<220>
<221>  MISC_FEATURE
<222>  (131)..(131)
<223>  X is V, C or T

<220>
<221>  MISC_FEATURE
<222>  (132)..(132)
<223>  X is E, N or T

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  X is S, L or I

<220>
<221>  MISC_FEATURE
<222>  (134)..(134)
<223>  X is I, S, A, H or N

<220>
<221>  MISC_FEATURE
<222>  (135)..(135)
<223>  X is G, N or absent

<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  X is K, S, H, F, Y, L or absent

<220>
<221>  MISC_FEATURE
<222>  (137)..(137)
<223>  X is T, K, G, I, R, V, M or absent

<220>
<221>  MISC_FEATURE
<222>  (138)..(138)
<223>  X is G, D, N, P, K, S or absent

<220>
<221>  MISC_FEATURE
<222>  (139)..(139)
<223>  X is D, K, G, N, or E

<220>
<221>  MISC_FEATURE
<222>  (140)..(140)
<223>  X is A, M, V, K, T or absent

<220>
<221>  MISC_FEATURE
<222>  (141)..(141)
<223>  X is A, L, D, Q, Y, F or absent

<220>
<221>  MISC_FEATURE
<222>  (142)..(142)
<223>  X is Q, Y, A, C< H, N or absent

<220>
<221>  MISC_FEATURE
<222>  (143)..(143)
<223>  X is I, L, V or M

<220>
<221>  MISC_FEATURE
<222>  (144)..(144)
<223>  X is I, L, V or A

<220>
<221>  MISC_FEATURE
<222>  (145)..(145)
<223>  X is I, L, V or A

<220>
<221>  MISC_FEATURE
<222>  (146)..(146)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (147)..(147)
<223>  X is A, I or C

<220>
<221>  MISC_FEATURE
<222>  (148)..(148)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (149)..(149)
<223>  X is I, V, L or F

<220>
<221>  MISC_FEATURE
<222>  (150)..(150)
<223>  X is N

<220>
<221>  MISC_FEATURE
<222>  (151)..(151)
<223>  X is V, L or M

<220>
<221>  MISC_FEATURE
<222>  (152)..(152)
<223>  X is A, N, S, T or D

<220>
<221>  MISC_FEATURE
<222>  (153)..(153)
<223>  X is N, Q, M, L, G or S

<220>
<221>  MISC_FEATURE
<222>  (154)..(154)
<223>  X is R, S, Q, A, D, L or E

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  X is R, E, K, I, P, G or S

<220>
<221>  MISC_FEATURE
<222>  (156)..(156)
<223>  X is R, D, P or absent

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  X is A, T or absent

<220>
<221>  MISC_FEATURE
<222>  (158)..(158)
<223>  X is V, G, I, T or absent

<220>
<221>  MISC_FEATURE
<222>  (159)..(159)
<223>  X is E, I, A, S, C or absent

<220>
<221>  MISC_FEATURE
<222>  (160)..(160)
<223>  X is V, L, I, E, P, Q or absent

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  X is Q, N, S, E, T or D

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  X is V, E, P, T, A, or D

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  X is V, I, G, L or W

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  X is N, K, S, R, A, I, V or Q

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  X is Q, D, E, T or R

<220>
<221>  MISC_FEATURE
<222>  (166)..(166)
<223>  X is G, R, I, P or E

<220>
<221>  MISC_FEATURE
<222>  (167)..(167)
<223>  X is W, A, Y, P, L or H

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  X is I, T, A, V, N or S

<220>
<221>  MISC_FEATURE
<222>  (169)..(169)
<223>  X is T, E, S, K, or absent

<220>
<221>  MISC_FEATURE
<222>  (170)..(170)
<223>  X is E, N or absent

<220>
<221>  MISC_FEATURE
<222>  (171)..(171)
<223>  X is R or absent

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  X is Q or absent

<220>
<221>  MISC_FEATURE
<222>  (173)..(173)
<223>  X is Q or absent

<220>
<221>  MISC_FEATURE
<222>  (174)..(174)
<223>  X is L, V, S, Q or absent

<220>
<221>  MISC_FEATURE
<222>  (175)..(175)
<223>  X is Q, Y, C, K, H, D, N or absent

<220>
<221>  MISC_FEATURE
<222>  (176)..(176)
<223>  X is E, G, L, N, P or K

<220>
<221>  MISC_FEATURE
<222>  (177)..(177)
<223>  X is A, I, E, D or P

<220>
<221>  MISC_FEATURE
<222>  (178)..(178)
<223>  X is G, T, D, L, R, A, G or E

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  X is I, G, L, P or S

<220>
<221>  MISC_FEATURE
<222>  (180)..(180)
<223>  X is N, K, D, H, T, P, E, Q or K

<220>
<221>  MISC_FEATURE
<222>  (181)..(181)
<223>  X is D, E, A, K, P or absent

<220>
<221>  MISC_FEATURE
<222>  (182)..(182)
<223>  X is L, V, I, W or F

<220>
<221>  MISC_FEATURE
<222>  (183)..(183)
<223>  X is D, E, K, S, R or Q

<220>
<221>  MISC_FEATURE
<222>  (184)..(184)
<223>  X is R, K, P, A or F

<220>
<221>  MISC_FEATURE
<222>  (185)..(185)
<223>  X is E, D< N, K, Q or V

<220>
<221>  MISC_FEATURE
<222>  (186)..(186)
<223>  X is T, E, M, K, C or Y

<220>
<221>  MISC_FEATURE
<222>  (187)..(187)
<223>  X is L, V , I or F

<220>
<221>  MISC_FEATURE
<222>  (188)..(188)
<223>  X is A, I, L or Q

<220>
<221>  MISC_FEATURE
<222>  (189)..(189)
<223>  X is A, L, P, S, D, or T

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  X is M, K, N, L, S, A or R

<220>
<221>  MISC_FEATURE
<222>  (191)..(191)
<223>  Xis L, V, A, F or Y

<220>
<221>  MISC_FEATURE
<222>  (192)..(192)
<223>  X is V, A, I, L, M or F

<220>
<221>  MISC_FEATURE
<222>  (193)..(193)
<223>  X is R, K, Q, P, Y, N or T

<220>
<221>  MISC_FEATURE
<222>  (194)..(194)
<223>  X is E, R, H, T, A, K, N, Q or V

<220>
<221>  MISC_FEATURE
<222>  (195)..(195)
<223>  X is L, I or F

<220>
<221>  MISC_FEATURE
<222>  (196)..(196)
<223>  X is D, E, R, S, Y or A

<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  X is A, E, T, S, R, V orK

<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  X is A, I, L, N, R, Y, or W

<220>
<221>  MISC_FEATURE
<222>  (199)..(199)
<223>  X is L, I, Q, H or Y

<220>
<221>  MISC_FEATURE
<222>  (200)..(200)
<223>  X is E, K, N, A, R or D

<220>
<221>  MISC_FEATURE
<222>  (201)..(201)
<223>  X is L, K, I , Q, R, or E

<220>
<221>  MISC_FEATURE
<222>  (202)..(202)
<223>  X is F or L

<220>
<221>  MISC_FEATURE
<222>  (203)..(203)
<223>  X is E, K, D, I, L or Q

<220>
<221>  MISC_FEATURE
<222>  (204)..(204)
<223>  X is Q, E, N, T or D

<220>
<221>  MISC_FEATURE
<222>  (205)..(205)
<223>  X is E, K, N, Y or Q

<220>
<221>  MISC_FEATURE
<222>  (206)..(206)
<223>  X is G, S or E

<220>
<221>  MISC_FEATURE
<222>  (207)..(207)
<223>  X is L, F, I, A or P

<220>
<221>  MISC_FEATURE
<222>  (208)..(208)
<223>  X is A, K, D, S, Q, or N

<220>
<221>  MISC_FEATURE
<222>  (209)..(209)
<223>  X is P, E, D, L, S or G

<220>
<221>  MISC_FEATURE
<222>  (210)..(210)
<223>  X is Y, E or absent

<220>
<221>  MISC_FEATURE
<222>  (211)..(211)
<223>  X is E or absent

<220>
<221>  MISC_FEATURE
<222>  (212)..(212)
<223>  X is I, L, V, Y or F

<220>
<221>  MISC_FEATURE
<222>  (213)..(213)
<223>  X is L, K, Q, R or E

<220>
<221>  MISC_FEATURE
<222>  (214)..(214)
<223>  X is S, Q, G, K, N, P or E

<220>
<221>  MISC_FEATURE
<222>  (215)..(215)
<223>  X is R, K, A, S, E or L

<220>
<221>  MISC_FEATURE
<222>  (216)..(216)
<223>  X is Y, W or I

<220>
<221>  MISC_FEATURE
<222>  (217)..(217)
<223>  X is E, Q, K, L or Y

<220>
<221>  MISC_FEATURE
<222>  (218)..(218)
<223>  X is R, K, S, A, E, or Q

<220>
<221>  MISC_FEATURE
<222>  (219)..(219)
<223>  X is L, K, Y, R or T

<220>
<221>  MISC_FEATURE
<222>  (220)..(220)
<223>  X is D, M, N, S, A or W

<220>
<221>  MISC_FEATURE
<222>  (221)..(221)
<223>  X is L, A, V, I or N

<220>
<221>  MISC_FEATURE
<222>  (222)..(222)
<223>  X is H, R, F, Y or T

<220>
<221>  MISC_FEATURE
<222>  (223)..(223)
<223>  X is I, L, S or G

<220>
<221>  MISC_FEATURE
<222>  (224)..(224)
<223>  X is G, N or D

<220>
<221>  MISC_FEATURE
<222>  (225)..(225)
<223>  X is R, E, S, K or Q

<220>
<221>  MISC_FEATURE
<222>  (226)..(226)
<223>  X is P, E, Q, I, T or R

<220>
<221>  MISC_FEATURE
<222>  (227)..(227)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (228)..(228)
<223>  X is K, R, H, N, I or T

<220>
<221>  MISC_FEATURE
<222>  (229)..(229)
<223>  X is L, V, A or I

<220>
<221>  MISC_FEATURE
<222>  (230)..(230)
<223>  X is G, A, I, L, R, P or Q

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  X is I, G, T, L, D, S or E

<220>
<221>  MISC_FEATURE
<222>  (232)..(232)
<223>  X is G, E, S, H, N, T or A

<220>
<221>  MISC_FEATURE
<222>  (233)..(233)
<223>  X is D, G, Q, N, T, S or E

<220>
<221>  MISC_FEATURE
<222>  (234)..(234)
<223>  X is K, G, N or A

<220>
<221>  MISC_FEATURE
<222>  (235)..(235)
<223>  X is E, D or absent

<220>
<221>  MISC_FEATURE
<222>  (236)..(236)
<223>  X is Q or absent

<220>
<221>  MISC_FEATURE
<222>  (237)..(237)
<223>  X is M or absent

<220>
<221>  MISC_FEATURE
<222>  (238)..(238)
<223>  X is V or absent

<220>
<221>  MISC_FEATURE
<222>  (239)..(239)
<223>  X is E, V, T, P or absent

<220>
<221>  MISC_FEATURE
<222>  (240)..(240)
<223>  X is S, I, Q, K, A or absent

<220>
<221>  MISC_FEATURE
<222>  (241)..(241)
<223>  X is F, T, S, H, A, or V

<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  X is G, I, V, M or S

<220>
<221>  MISC_FEATURE
<222>  (243)..(243)
<223>  X is I, T or K

<220>
<221>  MISC_FEATURE
<222>  (244)..(244)
<223>  X is S, L, E, V, F, T, Q or I

<220>
<221>  MISC_FEATURE
<222>  (245)..(245)
<223>  X is R, V, Q, Y, E or G

<220>
<221>  MISC_FEATURE
<222>  (246)..(246)
<223>  X is G, D or I

<220>
<221>  MISC_FEATURE
<222>  (247)..(247)
<223>  X is L, I or T

<220>
<221>  MISC_FEATURE
<222>  (248)..(248)
<223>  X is D, E, S or T

<220>
<221>  MISC_FEATURE
<222>  (249)..(249)
<223>  X is D, E, K, F, T or S

<220>
<221>  MISC_FEATURE
<222>  (250)..(250)
<223>  X is Q, K, R, D, S, Y or F

<220>
<221>  MISC_FEATURE
<222>  (251)..(251)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (252)..(252)
<223>  X is A, G, Y, L, F or absent

<220>
<221>  MISC_FEATURE
<222>  (253)..(253)
<223>  X is L, A or I

<220>
<221>  MISC_FEATURE
<222>  (254)..(254)
<223>  X is L, I, V, K or Q

<220>
<221>  MISC_FEATURE
<222>  (255)..(255)
<223>  X is V, A, I or L

<220>
<221>  MISC_FEATURE
<222>  (256)..(256)
<223>  X is E, L, G, R, K, Q, I or H

<220>
<221>  MISC_FEATURE
<222>  (257)..(257)
<223>  X is Q, T, C, G, E or L

<220>
<221>  MISC_FEATURE
<222>  (258)..(258)
<223>  X is E, G, P, L or absent

<220>
<221>  MISC_FEATURE
<222>  (259)..(259)
<223>  X is D, E, N, K, A, V or G

<220>
<221>  MISC_FEATURE
<222>  (260)..(260)
<223>  X is G, K, S, E or N

<220>
<221>  MISC_FEATURE
<222>  (261)..(261)
<223>  X is G, N, V, E or absent

<220>
<221>  MISC_FEATURE
<222>  (262)..(262)
<223>  X is S, N or absent

<220>
<221>  MISC_FEATURE
<222>  (263)..(263)
<223>  X is S or absent

<220>
<221>  MISC_FEATURE
<222>  (264)..(264)
<223>  X is T or absent

<220>
<221>  MISC_FEATURE
<222>  (265)..(265)
<223>  X is Q, E or absent

<220>
<221>  MISC_FEATURE
<222>  (266)..(266)
<223>  X is P, F or absent

<220>
<221>  MISC_FEATURE
<222>  (267)..(267)
<223>  X is T or absent

<220>
<221>  MISC_FEATURE
<222>  (268)..(268)
<223>  X is G, T or absent

<220>
<221>  MISC_FEATURE
<222>  (269)..(269)
<223>  X is N, K or absent

<220>
<221>  MISC_FEATURE
<222>  (270)..(270)
<223>  X is V, M or absent

<220>
<221>  MISC_FEATURE
<222>  (271)..(271)
<223>  X is I, V, R, Y, C or absent

<220>
<221>  MISC_FEATURE
<222>  (272)..(272)
<223>  X is I, Q, E, N, H, S or T

<220>
<221>  MISC_FEATURE
<222>  (273)..(273)
<223>  X is V, L, K, M or R

<220>
<221>  MISC_FEATURE
<222>  (274)..(274)
<223>  X is P, E, F, I, Q or H

<220>
<221>  MISC_FEATURE
<222>  (275)..(275)
<223>  X is P, W, I or N

<220>
<221>  MISC_FEATURE
<222>  (276)..(276)
<223>  X is M, L, S, A, D or absent

<220>
<221>  MISC_FEATURE
<222>  (277)..(277)
<223>  X is G or S

<220>
<221>  MISC_FEATURE
<222>  (278)..(278)
<223>  X is G, I, E or N

<220>
<221>  MISC_FEATURE
<222>  (279)..(279)
<223>  X is E, C, V, T, S or R

<220>
<221>  MISC_FEATURE
<222>  (280)..(280)
<223>  X is F, I, V or N

<220>
<221>  MISC_FEATURE
<222>  (281)..(281)
<223>  X is S, H, F, D or N

<220>
<221>  MISC_FEATURE
<222>  (282)..(282)
<223>  X is L, V, G, I, M or absent

<220>
<221>  MISC_FEATURE
<222>  (283)..(283)
<223>  X is L, G, R, F, M or D

<220>
<221>  MISC_FEATURE
<222>  (284)..(284)
<223>  X is R, K, H or absent

<220>
<221>  MISC_FEATURE
<222>  (285)..(285)
<223>  X is S, N, Q or absent

<220>
<221>  MISC_FEATURE
<222>  (286)..(286)
<223>  X is L, V or absent

<220>
<221>  MISC_FEATURE
<222>  (287)..(287)
<223>  X is S, I, R or absent

<220>
<221>  MISC_FEATURE
<222>  (288)..(288)
<223>  X is A, V, L, K, T or absent

<220>
<221>  MISC_FEATURE
<222>  (289)..(289)
<223>  X is E, K, R, P or absent

<220>
<221>  MISC_FEATURE
<222>  (290)..(290)
<223>  X is K, A or absent

<220>
<221>  MISC_FEATURE
<222>  (291)..(291)
<223>  X is V, T, L, R or absent

<400>  14

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa 
    290     


<210>  15
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
atgttcaaga acctgatctg gctgaaggag gtggacagca cccaggagag actgaaggag       60

tggaacgtga gctacggcac cgccctggtg gccgacagac agaccaaggg cagaggcggc      120

ctgggcagaa agtggctgag ccaggagggc ggcctgtact tcagcttcct gctgaacccc      180

aaggagttcg agaacctgct gcagctgccc ctggtgctgg gcctgagcgt gagcgaggcc      240

ctggaggaga tcaccgagat ccccttcagc ctgaagtggc ccaacgacgt gtacttccag      300

gagaagaagg tgagcggcgt gctgtgcgag ctgagcaagg acaagctgat cgtgggcatc      360

ggcatcaacg tgaaccagag agagatcccc gaggagatca aggacagagc caccaccctg      420

tacgagatca ccggcaagga ctgggacaga aaggaggtgc tgctgaaggt gctgaagaga      480

atcagcgaga acctgaagaa gttcaaggag aagagcttca aggagttcaa gggcaagatc      540

gagagcaaga tgctgtacct gggcgaggag gtgaagctgc tgggcgaggg caagatcacc      600

ggcaagctgg tgggcctgag cgagaagggc ggcgccctga tcctgaccga ggagggcatc      660

aaggagatcc tgagcggcga gttcagcctg agaagaagct ga                         702


<210>  16
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Phe Lys Asn Leu Ile Trp Leu Lys Glu Val Asp Ser Thr Gln Glu 
1               5                   10                  15      


Arg Leu Lys Glu Trp Asn Val Ser Tyr Gly Thr Ala Leu Val Ala Asp 
            20                  25                  30          


Arg Gln Thr Lys Gly Arg Gly Gly Leu Gly Arg Lys Trp Leu Ser Gln 
        35                  40                  45              


Glu Gly Gly Leu Tyr Phe Ser Phe Leu Leu Asn Pro Lys Glu Phe Glu 
    50                  55                  60                  


Asn Leu Leu Gln Leu Pro Leu Val Leu Gly Leu Ser Val Ser Glu Ala 
65                  70                  75                  80  


Leu Glu Glu Ile Thr Glu Ile Pro Phe Ser Leu Lys Trp Pro Asn Asp 
                85                  90                  95      


Val Tyr Phe Gln Glu Lys Lys Val Ser Gly Val Leu Cys Glu Leu Ser 
            100                 105                 110         


Lys Asp Lys Leu Ile Val Gly Ile Gly Ile Asn Val Asn Gln Arg Glu 
        115                 120                 125             


Ile Pro Glu Glu Ile Lys Asp Arg Ala Thr Thr Leu Tyr Glu Ile Thr 
    130                 135                 140                 


Gly Lys Asp Trp Asp Arg Lys Glu Val Leu Leu Lys Val Leu Lys Arg 
145                 150                 155                 160 


Ile Ser Glu Asn Leu Lys Lys Phe Lys Glu Lys Ser Phe Lys Glu Phe 
                165                 170                 175     


Lys Gly Lys Ile Glu Ser Lys Met Leu Tyr Leu Gly Glu Glu Val Lys 
            180                 185                 190         


Leu Leu Gly Glu Gly Lys Ile Thr Gly Lys Leu Val Gly Leu Ser Glu 
        195                 200                 205             


Lys Gly Gly Ala Leu Ile Leu Thr Glu Glu Gly Ile Lys Glu Ile Leu 
    210                 215                 220                 


Ser Gly Glu Phe Ser Leu Arg Arg Ser 
225                 230             


<210>  17
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is A, L, I, T, V, or is absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is C, L, V, H, A, or is absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is I, V or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is A

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is E, D, R, T, N, V, or A

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is , R, K, E, or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Q

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is A, K, N, S, Q, or E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is R or K

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is R, L, W, G, or S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is R or N

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is K, Q, V, E, T, M, or A

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is W

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is L, I, or V

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is S

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is P

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is F, E, A, K, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is G

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is V, C or absent

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is A, C or absent

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is A, L or absent

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is A, G, S or absent

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X is N, G, Q, T, or C

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is A, V or L

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is L, G, V or I

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is S

<400>  17

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  18
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 
1               5                   10                  15      


Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 
            20                  25                  30          


Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 
        35                  40                  45              


Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 
    50                  55                  60                  


Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 
65                  70                  75                  80  


Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 
                85                  90                  95      


Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 
            100                 105                 110         


Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 
        115                 120                 125             


Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
    130                 135                 140                 


Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
145                 150                 155                 160 


Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 
                165                 170                 175     


Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 
            180                 185                 190         


Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 
        195                 200                 205             


Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 
    210                 215                 220                 


Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 
225                 230                 235                 240 


Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 
                245                 250                 255     


Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 
            260                 265                 270         


Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 
        275                 280                 285             


His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 
    290                 295                 300                 


Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 
305                 310                 315                 320 


Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 
                325                 330                 335     


Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 
            340                 345                 350         


Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 
        355                 360                 365             


Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
    370                 375                 380                 


Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 
385                 390                 395                 400 


Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 
                405                 410                 415     


Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 
            420                 425                 430         


His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 
        435                 440                 445             


Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 
    450                 455                 460                 


Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 
465                 470                 475                 480 


Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 
                485                 490                 495     


Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 
            500                 505                 510         


Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 
        515                 520                 525             


Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 
    530                 535                 540                 


Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 
545                 550                 555                 560 


Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro 
                565                 570                 575     


Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly 
            580                 585                 590         


Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly 
        595                 600                 605             


Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg 
    610                 615                 620                 


Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn 
625                 630                 635                 640 


Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln 
                645                 650                 655     


Ser Pro Gln Asn Cys Ser Ile Met 
            660                 


<210>  19
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  20
<211>  717
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Arg Arg Ser Gln Arg Leu Thr Arg Tyr Ser Gln Gly Asp Asp 
1               5                   10                  15      


Asp Gly Ser Ser Ser Ser Gly Gly Ser Ser Val Ala Gly Ser Gln Ser 
            20                  25                  30          


Thr Leu Phe Lys Asp Ser Pro Leu Arg Thr Leu Lys Arg Lys Ser Ser 
        35                  40                  45              


Asn Met Lys Arg Leu Ser Pro Ala Pro Gln Leu Gly Pro Ser Ser Asp 
    50                  55                  60                  


Ala His Thr Ser Tyr Tyr Ser Glu Ser Leu Val His Glu Ser Trp Phe 
65                  70                  75                  80  


Pro Pro Arg Ser Ser Leu Glu Glu Leu His Gly Asp Ala Asn Trp Gly 
                85                  90                  95      


Glu Asp Leu Arg Val Arg Arg Arg Arg Gly Thr Gly Gly Ser Glu Ser 
            100                 105                 110         


Ser Arg Ala Ser Gly Leu Val Gly Arg Lys Ala Thr Glu Asp Phe Leu 
        115                 120                 125             


Gly Ser Ser Ser Gly Tyr Ser Ser Glu Asp Asp Tyr Val Gly Tyr Ser 
    130                 135                 140                 


Asp Val Asp Gln Gln Ser Ser Ser Ser Arg Leu Arg Ser Ala Val Ser 
145                 150                 155                 160 


Arg Ala Gly Ser Leu Leu Trp Met Val Ala Thr Ser Pro Gly Arg Leu 
                165                 170                 175     


Phe Arg Leu Leu Tyr Trp Trp Ala Gly Thr Thr Trp Tyr Arg Leu Thr 
            180                 185                 190         


Thr Ala Ala Ser Leu Leu Asp Val Phe Val Leu Thr Arg Arg Phe Ser 
        195                 200                 205             


Ser Leu Lys Thr Phe Leu Trp Phe Leu Leu Pro Leu Leu Leu Leu Thr 
    210                 215                 220                 


Cys Leu Thr Tyr Gly Ala Trp Tyr Phe Tyr Pro Tyr Gly Leu Gln Thr 
225                 230                 235                 240 


Phe His Pro Ala Leu Val Ser Trp Trp Ala Ala Lys Asp Ser Arg Arg 
                245                 250                 255     


Pro Asp Glu Gly Trp Glu Ala Arg Asp Ser Ser Pro His Phe Gln Ala 
            260                 265                 270         


Glu Gln Arg Val Met Ser Arg Val His Ser Leu Glu Arg Arg Leu Glu 
        275                 280                 285             


Ala Leu Ala Ala Glu Phe Ser Ser Asn Trp Gln Lys Glu Ala Met Arg 
    290                 295                 300                 


Leu Glu Arg Leu Glu Leu Arg Gln Gly Ala Pro Gly Gln Gly Gly Gly 
305                 310                 315                 320 


Gly Gly Leu Ser His Glu Asp Thr Leu Ala Leu Leu Glu Gly Leu Val 
                325                 330                 335     


Ser Arg Arg Glu Ala Ala Leu Lys Glu Asp Phe Arg Arg Glu Thr Ala 
            340                 345                 350         


Ala Arg Ile Gln Glu Glu Leu Ser Ala Leu Arg Ala Glu His Gln Gln 
        355                 360                 365             


Asp Ser Glu Asp Leu Phe Lys Lys Ile Val Arg Ala Ser Gln Glu Ser 
    370                 375                 380                 


Glu Ala Arg Ile Gln Gln Leu Lys Ser Glu Trp Gln Ser Met Thr Gln 
385                 390                 395                 400 


Glu Ser Phe Gln Glu Ser Ser Val Lys Glu Leu Arg Arg Leu Glu Asp 
                405                 410                 415     


Gln Leu Ala Gly Leu Gln Gln Glu Leu Ala Ala Leu Ala Leu Lys Gln 
            420                 425                 430         


Ser Ser Val Ala Glu Glu Val Gly Leu Leu Pro Gln Gln Ile Gln Ala 
        435                 440                 445             


Val Arg Asp Asp Val Glu Ser Gln Phe Pro Ala Trp Ile Ser Gln Phe 
    450                 455                 460                 


Leu Ala Arg Gly Gly Gly Gly Arg Val Gly Leu Leu Gln Arg Glu Glu 
465                 470                 475                 480 


Met Gln Ala Gln Leu Arg Glu Leu Glu Ser Lys Ile Leu Thr His Val 
                485                 490                 495     


Ala Glu Met Gln Gly Lys Ser Ala Arg Glu Ala Ala Ala Ser Leu Ser 
            500                 505                 510         


Leu Thr Leu Gln Lys Glu Gly Val Ile Gly Val Thr Glu Glu Gln Val 
        515                 520                 525             


His His Ile Val Lys Gln Ala Leu Gln Arg Tyr Ser Glu Asp Arg Ile 
    530                 535                 540                 


Gly Leu Ala Asp Tyr Ala Leu Glu Ser Gly Gly Ala Ser Val Ile Ser 
545                 550                 555                 560 


Thr Arg Cys Ser Glu Thr Tyr Glu Thr Lys Thr Ala Leu Leu Ser Leu 
                565                 570                 575     


Phe Gly Ile Pro Leu Trp Tyr His Ser Gln Ser Pro Arg Val Ile Leu 
            580                 585                 590         


Gln Pro Asp Val His Pro Gly Asn Cys Trp Ala Phe Gln Gly Pro Gln 
        595                 600                 605             


Gly Phe Ala Val Val Arg Leu Ser Ala Arg Ile Arg Pro Thr Ala Val 
    610                 615                 620                 


Thr Leu Glu His Val Pro Lys Ala Leu Ser Pro Asn Ser Thr Ile Ser 
625                 630                 635                 640 


Ser Ala Pro Lys Asp Phe Ala Ile Phe Gly Phe Asp Glu Asp Leu Gln 
                645                 650                 655     


Gln Glu Gly Thr Leu Leu Gly Lys Phe Thr Tyr Asp Gln Asp Gly Glu 
            660                 665                 670         


Pro Ile Gln Thr Phe His Phe Gln Ala Pro Thr Met Ala Thr Tyr Gln 
        675                 680                 685             


Val Val Glu Leu Arg Ile Leu Thr Asn Trp Gly His Pro Glu Tyr Thr 
    690                 695                 700                 


Cys Ile Tyr Arg Phe Arg Val His Gly Glu Pro Ala His 
705                 710                 715         


<210>  21
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asp Arg Ser Gly Phe Gly Glu Ile Ser Ser Pro Val Ile Arg Glu 
1               5                   10                  15      


Ala Glu Val Thr Arg Thr Ala Arg Lys Gln Ser Ala Gln Lys Arg Val 
            20                  25                  30          


Leu Leu Gln Ala Ser Gln Asp Glu Asn Phe Gly Asn Thr Thr Pro Arg 
        35                  40                  45              


Asn Gln Val Ile Pro Arg Thr Pro Ser Ser Phe Arg Gln Pro Phe Thr 
    50                  55                  60                  


Pro Thr Ser Arg Ser Leu Leu Arg Gln Pro Asp Ile Ser Cys Ile Leu 
65                  70                  75                  80  


Gly Thr Gly Gly Lys Ser Pro Arg Leu Thr Gln Ser Ser Gly Phe Phe 
                85                  90                  95      


Gly Asn Leu Ser Met Val Thr Asn Leu Asp Asp Ser Asn Trp Ala Ala 
            100                 105                 110         


Ala Phe Ser Ser Gln Arg Ser Gly Leu Phe Thr Asn Thr Glu Pro His 
        115                 120                 125             


Ser Ile Thr Glu Asp Val Thr Ile Ser Ala Val Met Leu Arg Glu Asp 
    130                 135                 140                 


Asp Pro Gly Glu Ala Ala Ser Met Ser Met Phe Ser Asp Phe Leu Gln 
145                 150                 155                 160 


Ser Phe Leu Lys His Ser Ser Ser Thr Val Phe Asp Leu Val Glu Glu 
                165                 170                 175     


Tyr Glu Asn Ile Cys Gly Ser Gln Val Asn Ile Leu Ser Lys Ile Val 
            180                 185                 190         


Ser Arg Ala Thr Pro Gly Leu Gln Lys Phe Ser Lys Thr Ala Ser Met 
        195                 200                 205             


Leu Trp Leu Leu Gln Gln Glu Met Val Thr Trp Arg Leu Leu Ala Ser 
    210                 215                 220                 


Leu Tyr Arg Asp Arg Ile Gln Ser Ala Leu Glu Glu Glu Ser Val Phe 
225                 230                 235                 240 


Ala Val Thr Ala Val Asn Ala Ser Glu Lys Thr Val Val Glu Ala Leu 
                245                 250                 255     


Phe Gln Arg Asp Ser Leu Val Arg Gln Ser Gln Leu Val Val Asp Trp 
            260                 265                 270         


Leu Glu Ser Ile Ala Lys Asp Glu Ile Gly Glu Phe Ser Asp Asn Ile 
        275                 280                 285             


Glu Phe Tyr Ala Lys Ser Val Tyr Trp Glu Asn Thr Leu His Thr Leu 
    290                 295                 300                 


Lys Gln Arg Gln Leu Thr Ser Tyr Val Gly Ser Val Arg Pro Leu Val 
305                 310                 315                 320 


Thr Glu Leu Asp Pro Asp Ala Pro Ile Arg Gln Lys Met Pro Leu Asp 
                325                 330                 335     


Asp Leu Asp Arg Glu Asp Glu Val Arg Leu Leu Lys Tyr Leu Phe Thr 
            340                 345                 350         


Leu Ile Arg Ala Gly Met Thr Glu Glu Ala Gln Arg Leu Cys Lys Arg 
        355                 360                 365             


Cys Gly Gln Ala Trp Arg Ala Ala Thr Leu Glu Gly Trp Lys Leu Tyr 
    370                 375                 380                 


His Asp Pro Asn Val Asn Gly Gly Thr Glu Leu Glu Pro Val Glu Gly 
385                 390                 395                 400 


Asn Pro Tyr Arg Arg Ile Trp Lys Ile Ser Cys Trp Arg Met Ala Glu 
                405                 410                 415     


Asp Glu Leu Phe Asn Arg Tyr Glu Arg Ala Ile Tyr Ala Ala Leu Ser 
            420                 425                 430         


Gly Asn Leu Lys Gln Leu Leu Pro Val Cys Asp Thr Trp Glu Asp Thr 
        435                 440                 445             


Val Trp Ala Tyr Phe Arg Val Met Val Asp Ser Leu Val Glu Gln Glu 
    450                 455                 460                 


Ile Gln Thr Ser Val Ala Thr Leu Asp Glu Thr Glu Glu Leu Pro Arg 
465                 470                 475                 480 


Glu Tyr Leu Gly Ala Asn Trp Thr Leu Glu Lys Val Phe Glu Glu Leu 
                485                 490                 495     


Gln Ala Thr Asp Lys Lys Arg Val Leu Glu Glu Asn Gln Glu His Tyr 
            500                 505                 510         


His Ile Val Gln Lys Phe Leu Ile Leu Gly Asp Ile Asp Gly Leu Met 
        515                 520                 525             


Asp Glu Phe Ser Lys Trp Leu Ser Lys Ser Arg Asn Asn Leu Pro Gly 
    530                 535                 540                 


His Leu Leu Arg Phe Met Thr His Leu Ile Leu Phe Phe Arg Thr Leu 
545                 550                 555                 560 


Gly Leu Gln Thr Lys Glu Glu Val Ser Ile Glu Val Leu Lys Thr Tyr 
                565                 570                 575     


Ile Gln Leu Leu Ile Arg Glu Lys His Thr Asn Leu Ile Ala Phe Tyr 
            580                 585                 590         


Thr Cys His Leu Pro Gln Asp Leu Ala Val Ala Gln Tyr Ala Leu Phe 
        595                 600                 605             


Leu Glu Ser Val Thr Glu Phe Glu Gln Arg His His Cys Leu Glu Leu 
    610                 615                 620                 


Ala Lys Glu Ala Asp Leu Asp Val Ala Thr Ile Thr Lys Thr Val Val 
625                 630                 635                 640 


Glu Asn Ile Arg Lys Lys Asp Asn Gly Glu Phe Ser His His Asp Leu 
                645                 650                 655     


Ala Pro Ala Leu Asp Thr Gly Thr Thr Glu Glu Asp Arg Leu Lys Ile 
            660                 665                 670         


Asp Val Ile Asp Trp Leu Val Phe Asp Pro Ala Gln Arg Ala Glu Ala 
        675                 680                 685             


Leu Lys Gln Gly Asn Ala Ile Met Arg Lys Phe Leu Ala Ser Lys Lys 
    690                 695                 700                 


His Glu Ala Ala Lys Glu Val Phe Val Lys Ile Pro Gln Asp Ser Ile 
705                 710                 715                 720 


Ala Glu Ile Tyr Asn Gln Cys Glu Glu Gln Gly Met Glu Ser Pro Leu 
                725                 730                 735     


Pro Ala Glu Asp Asp Asn Ala Ile Arg Glu His Leu Cys Ile Arg Ala 
            740                 745                 750         


Tyr Leu Glu Ala His Glu Thr Phe Asn Glu Trp Phe Lys His Met Asn 
        755                 760                 765             


Ser Val Pro Gln Lys Pro Ala Leu Ile Pro Gln Pro Thr Phe Thr Glu 
    770                 775                 780                 


Lys Val Ala His Glu His Lys Glu Lys Lys Tyr Glu Met Asp Phe Gly 
785                 790                 795                 800 


Ile Trp Lys Gly His Leu Asp Ala Leu Thr Ala Asp Val Lys Glu Lys 
                805                 810                 815     


Met Tyr Asn Val Leu Leu Phe Val Asp Gly Gly Trp Met Val Asp Val 
            820                 825                 830         


Arg Glu Asp Ala Lys Glu Asp His Glu Arg Thr His Gln Met Val Leu 
        835                 840                 845             


Leu Arg Lys Leu Cys Leu Pro Met Leu Cys Phe Leu Leu His Thr Ile 
    850                 855                 860                 


Leu His Ser Thr Gly Gln Tyr Gln Glu Cys Leu Gln Leu Ala Asp Met 
865                 870                 875                 880 


Val Ser Ser Glu Arg His Lys Leu Tyr Leu Val Phe Ser Lys Glu Glu 
                885                 890                 895     


Leu Arg Lys Leu Leu Gln Lys Leu Arg Glu Ser Ser Leu Met Leu Leu 
            900                 905                 910         


Asp Gln Gly Leu Asp Pro Leu Gly Tyr Glu Ile Gln Leu 
        915                 920                 925 


<210>  22
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Leu Gly Arg Ala Val Leu Gly Leu Leu Leu Leu Ala Pro Ser 
1               5                   10                  15      


Val Val Gln Ala Val Glu Pro Ile Ser Leu Gly Leu Ala Leu Ala Gly 
            20                  25                  30          


Val Leu Thr Gly Tyr Ile Tyr Pro Arg Leu Tyr Cys Leu Phe Ala Glu 
        35                  40                  45              


Cys Cys Gly Gln Lys Arg Ser Leu Ser Arg Glu Ala Leu Gln Lys Asp 
    50                  55                  60                  


Leu Asp Asp Asn Leu Phe Gly Gln His Leu Ala Lys Lys Ile Ile Leu 
65                  70                  75                  80  


Asn Ala Val Phe Gly Phe Ile Asn Asn Pro Lys Pro Lys Lys Pro Leu 
                85                  90                  95      


Thr Leu Ser Leu His Gly Trp Thr Gly Thr Gly Lys Asn Phe Val Ser 
            100                 105                 110         


Lys Ile Ile Ala Glu Asn Ile Tyr Glu Gly Gly Leu Asn Ser Asp Tyr 
        115                 120                 125             


Val His Leu Phe Val Ala Thr Leu His Phe Pro His Ala Ser Asn Ile 
    130                 135                 140                 


Thr Leu Tyr Lys Asp Gln Leu Gln Leu Trp Ile Arg Gly Asn Val Ser 
145                 150                 155                 160 


Ala Cys Ala Arg Ser Ile Phe Ile Phe Asp Glu Met Asp Lys Met His 
                165                 170                 175     


Ala Gly Leu Ile Asp Ala Ile Lys Pro Phe Leu Asp Tyr Tyr Asp Leu 
            180                 185                 190         


Val Asp Gly Val Ser Tyr Gln Lys Ala Met Phe Ile Phe Leu Ser Asn 
        195                 200                 205             


Ala Gly Ala Glu Arg Ile Thr Asp Val Ala Leu Asp Phe Trp Arg Ser 
    210                 215                 220                 


Gly Lys Gln Arg Glu Asp Ile Lys Leu Lys Asp Ile Glu His Ala Leu 
225                 230                 235                 240 


Ser Val Ser Val Phe Asn Asn Lys Asn Ser Gly Phe Trp His Ser Ser 
                245                 250                 255     


Leu Ile Asp Arg Asn Leu Ile Asp Tyr Phe Val Pro Phe Leu Pro Leu 
            260                 265                 270         


Glu Tyr Lys His Leu Lys Met Cys Ile Arg Val Glu Met Gln Ser Arg 
        275                 280                 285             


Gly Tyr Glu Ile Asp Glu Asp Ile Val Ser Arg Val Ala Glu Glu Met 
    290                 295                 300                 


Thr Phe Phe Pro Lys Glu Glu Arg Val Phe Ser Asp Lys Gly Cys Lys 
305                 310                 315                 320 


Thr Val Phe Thr Lys Leu Asp Tyr Tyr Tyr Asp Asp 
                325                 330         


