               SEQUENCE LISTING

<110> BenF AB

<120> Regulation of meal-induced intestinal ketogensis

<130> BENFB/P54545PC

<150> GB1219678.8
<151> 2012-11-01

<160> 7

<170> BiSSAP 1.2

<210> 1
<211> 508
<212> PRT
<213> Homo sapiens

<400> 1
Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg 
1               5                   10                  15      
Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala 
            20                  25                  30          
His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp 
        35                  40                  45              
Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
    50                  55                  60                  
Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu 
65                  70                  75                  80  
Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                85                  90                  95      
Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
            100                 105                 110         
Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu 
        115                 120                 125             
Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
    130                 135                 140                 
Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
145                 150                 155                 160 
Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                165                 170                 175     
Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala Met Val 
            180                 185                 190         
Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr 
        195                 200                 205             
Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
    210                 215                 220                 
Ala Leu Glu Arg Gly Leu Arg Gly Thr Tyr Met Glu Asn Val Tyr Asp 
225                 230                 235                 240 
Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys 
                245                 250                 255     
Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser 
            260                 265                 270         
Tyr Arg Lys Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg 
        275                 280                 285             
Pro Phe Thr Leu Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe 
    290                 295                 300                 
Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
305                 310                 315                 320 
Leu Ser Ala Ser Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu 
                325                 330                 335     
Ala Phe Gly Gly Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu 
            340                 345                 350         
Asp Lys Ala Leu Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr 
        355                 360                 365             
Lys Ala Ser Leu Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser 
    370                 375                 380                 
Thr Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
385                 390                 395                 400 
Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                405                 410                 415     
Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly 
            420                 425                 430         
Ser Pro Leu Asp Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg 
        435                 440                 445             
Leu Ala Ser Arg Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met 
    450                 455                 460                 
Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
465                 470                 475                 480 
Asp Thr Asn Ser Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                485                 490                 495     
Glu Gln His Arg Arg Lys Tyr Ala Arg Arg Pro Val 
            500                 505             

<210> 2
<211> 508
<212> PRT
<213> Homo sapiens

<400> 2
Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg 
1               5                   10                  15      
Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala 
            20                  25                  30          
His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp 
        35                  40                  45              
Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
    50                  55                  60                  
Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu 
65                  70                  75                  80  
Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                85                  90                  95      
Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
            100                 105                 110         
Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu 
        115                 120                 125             
Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
    130                 135                 140                 
Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
145                 150                 155                 160 
Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                165                 170                 175     
Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala Met Val 
            180                 185                 190         
Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr 
        195                 200                 205             
Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
    210                 215                 220                 
Ala Leu Glu Arg Gly Leu Arg Gly Thr His Met Glu Asn Val Tyr Asp 
225                 230                 235                 240 
Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys 
                245                 250                 255     
Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser 
            260                 265                 270         
Tyr Arg Lys Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg 
        275                 280                 285             
Pro Phe Thr Leu Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe 
    290                 295                 300                 
Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
305                 310                 315                 320 
Leu Ser Ala Ser Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu 
                325                 330                 335     
Ala Phe Gly Gly Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu 
            340                 345                 350         
Asp Lys Ala Leu Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr 
        355                 360                 365             
Lys Ala Ser Leu Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser 
    370                 375                 380                 
Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
385                 390                 395                 400 
Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                405                 410                 415     
Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly 
            420                 425                 430         
Ser Pro Leu Asp Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg 
        435                 440                 445             
Leu Ala Ser Arg Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met 
    450                 455                 460                 
Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
465                 470                 475                 480 
Asp Thr Asn Ser Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                485                 490                 495     
Glu Gln His Arg Arg Lys Tyr Ala Arg Arg Pro Val 
            500                 505             

<210> 3
<211> 508
<212> PRT
<213> Homo sapiens

<400> 3
Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg 
1               5                   10                  15      
Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala 
            20                  25                  30          
His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp 
        35                  40                  45              
Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
    50                  55                  60                  
Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu 
65                  70                  75                  80  
Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                85                  90                  95      
Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
            100                 105                 110         
Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu 
        115                 120                 125             
Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
    130                 135                 140                 
Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
145                 150                 155                 160 
Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                165                 170                 175     
Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala Met Val 
            180                 185                 190         
Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr 
        195                 200                 205             
Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
    210                 215                 220                 
Ala Leu Glu Arg Gly Leu Arg Gly Thr His Met Glu Asn Val Tyr Asp 
225                 230                 235                 240 
Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys 
                245                 250                 255     
Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser 
            260                 265                 270         
Tyr Arg Lys Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg 
        275                 280                 285             
Pro Phe Thr Leu Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe 
    290                 295                 300                 
Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
305                 310                 315                 320 
Leu Ser Ala Ser Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu 
                325                 330                 335     
Ala Phe Gly Gly Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu 
            340                 345                 350         
Asp Lys Ala Leu Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr 
        355                 360                 365             
Lys Ala Ser Leu Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser 
    370                 375                 380                 
Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
385                 390                 395                 400 
Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                405                 410                 415     
Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly 
            420                 425                 430         
Ser Pro Leu Asp Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg 
        435                 440                 445             
Leu Ala Ser Arg Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met 
    450                 455                 460                 
Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
465                 470                 475                 480 
Asp Thr Asn Ser Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                485                 490                 495     
Glu Gln His Arg Arg Lys Tyr Ala Arg Arg Pro Val 
            500                 505             

<210> 4
<211> 466
<212> PRT
<213> Homo sapiens

<400> 4
Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg 
1               5                   10                  15      
Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala 
            20                  25                  30          
His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp 
        35                  40                  45              
Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
    50                  55                  60                  
Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu 
65                  70                  75                  80  
Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                85                  90                  95      
Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
            100                 105                 110         
Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu 
        115                 120                 125             
Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
    130                 135                 140                 
Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
145                 150                 155                 160 
Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                165                 170                 175     
Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Leu Arg Gly Thr His 
            180                 185                 190         
Met Glu Asn Val Tyr Asp Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr 
        195                 200                 205             
Pro Ile Val Asp Gly Lys Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu 
    210                 215                 220                 
Asp Arg Cys Tyr Thr Ser Tyr Arg Lys Lys Ile Gln Asn Gln Trp Lys 
225                 230                 235                 240 
Gln Ala Gly Ser Asp Arg Pro Phe Thr Leu Asp Asp Leu Gln Tyr Met 
                245                 250                 255     
Ile Phe His Thr Pro Phe Cys Lys Met Val Gln Lys Ser Leu Ala Arg 
            260                 265                 270         
Leu Met Phe Asn Asp Phe Leu Ser Ala Ser Ser Asp Thr Gln Thr Ser 
        275                 280                 285             
Leu Tyr Lys Gly Leu Glu Ala Phe Gly Gly Leu Lys Leu Glu Asp Thr 
    290                 295                 300                 
Tyr Thr Asn Lys Asp Leu Asp Lys Ala Leu Leu Lys Ala Ser Gln Asp 
305                 310                 315                 320 
Met Phe Asp Lys Lys Thr Lys Ala Ser Leu Tyr Leu Ser Thr His Asn 
                325                 330                 335     
Gly Asn Met Tyr Thr Ser Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu 
            340                 345                 350         
Ser His His Ser Ala Gln Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe 
        355                 360                 365             
Ser Tyr Gly Ser Gly Leu Ala Ala Ser Phe Phe Ser Phe Arg Val Ser 
    370                 375                 380                 
Gln Asp Ala Ala Pro Gly Ser Pro Leu Asp Lys Leu Val Ser Ser Thr 
385                 390                 395                 400 
Ser Asp Leu Pro Lys Arg Leu Ala Ser Arg Lys Cys Val Ser Pro Glu 
                405                 410                 415     
Glu Phe Thr Glu Ile Met Asn Gln Arg Glu Gln Phe Tyr His Lys Val 
            420                 425                 430         
Asn Phe Ser Pro Pro Gly Asp Thr Asn Ser Leu Phe Pro Gly Thr Trp 
        435                 440                 445             
Tyr Leu Glu Arg Val Asp Glu Gln His Arg Arg Lys Tyr Ala Arg Arg 
    450                 455                 460                 
Pro Val 
465     

<210> 5
<211> 13
<212> DNA
<213> Homo sapiens

<400> 5
agacctttgg ccc                                                       13


<210> 6
<211> 10
<212> DNA
<213> Homo sapiens

<400> 6
tgatgttttc                                                           10


<210> 7
<211> 15
<212> DNA
<213> Homo sapiens

<400> 7
gctacaggtt gtgct                                                     15


