                         SEQUENCE LISTING

<110>  INSTITUT GUSTAVE-ROUSSY
       UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
	BELLANE-CHANTELOT, Christine
	PLO, Isabelle
	SAINT-MARTIN, Ccile
	MARTY, Caroline
	VAINCHENKER, William
 
<120>  IDENTIFICATION, ASSESSMENT AND THERAPY OF ESSENTIAL 
       THROMBOCYTHEMIA WITH RESISTANCE TO JAK2 INHIBITORS

<130>  364156 D31626

<150>  EP12306361.2
<151>  2012-10-31

<150>  US61/720693
<151>  2012-10-31

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  1132
<212>  PRT
<213>  homo sapiens

<400>  1

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Val Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


Tyr Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


Pro Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Asp Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Met  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  2
<211>  1132
<212>  PRT
<213>  homo sapiens

<400>  2

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Val Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


Pro Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Phe Cys Gly Asp Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Met  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  3
<211>  1132
<212>  PRT
<213>  homo sapiens

<400>  3

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Val Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


Pro Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Asp Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Arg Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Met  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  4
<211>  1132
<212>  PRT
<213>  homo sapiens

<400>  4

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Val Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


Pro Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Asp Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Gln Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Met  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  5
<211>  1132
<212>  PRT
<213>  homo sapiens

<400>  5

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Val Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


Pro Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Asp Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Gln Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Met  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  6
<211>  1132
<212>  PRT
<213>  homo sapiens

<400>  6

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Val Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


Pro Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Asp Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Arg Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Gln Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Met  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  7
<211>  3399
<212>  DNA
<213>  homo sapiens

<400>  7
atgggaatgg cctgccttac gatgacagaa atggagggaa catccacctc ttctatatat       60

cagaatggtg atatttctgg aaatgccaat tctatgaagc aaatagatcc agttcttcag      120

gtgtatcttt accattccct tgggaaatct gaggcagatt atctgacctt tccatctggg      180

gagtatgttg cagaagaaat ctgtattgct gcttctaaag cttgtggtat cacacctgtg      240

tatcataata tgtttgcttt aatgagtgaa acagaaagga tctggtatcc acccaaccat      300

gtcttccata tagatgagtc aaccaggcat aatgtactct acagaataag attttacttt      360

cctcgttggt attgcagtgg cagcaacaga gcctatcggc atggaatatc tcgaggtgct      420

gaagctcctc ttcttgatga ctttgtcatg tcttacctct ttgctcagtg gcggcatgat      480

tttgtgcacg gatggataaa agtacctgtg actcatgaaa cacaggaaga atgtcttggg      540

atggcagtgt tagatatgat gagaatagcc aaagaaaacg atcaaacccc actggccatc      600

tataactcta tcagctacaa gacattctta ccaaaatgta ttcgagcaaa gatccaagac      660

tatcatattt tgacaaggaa gcgaataagg tacagatttc gcagatttat tcagcaattc      720

agccaatgca aagccactgc cagaaacttg aaacttaagt atcttataaa tctggaaact      780

ctgcagtctg ccttctacac agagaaattt gaagtaaaag aacctggaag tggtccttca      840

ggtgaggaga tttttgcaac cattataata actggaaacg gtggaattca gtggtcaaga      900

gggaaacata aagaaagtga gacactgaca gaacaggatt tacagttata ttgcgatttt      960

cctaatatta ttgatgtcag tattaagcaa gcaaaccaag agggttcaaa tgaaagccga     1020

gttgtaacta tccataagca agatggtaaa aatctggaaa ttgaacttag ctcattaagg     1080

gaagctttgt ctttcgtgtc attaattgat ggatattata gattaactgc agatgcacat     1140

cattacctct gtaaagaagt agcacctcca gccgtgcttg aaaatataca aagcaactgt     1200

tatggcccaa tttcgatgga ttttgccatt agtaaactga agaaagcagg taatcagact     1260

ggactgtatg tacttcgatg cagtcctaag gactttaata aatatttttt gacttttgct     1320

gtcgagcgag aaaatgtcat tgaatataaa cactgtttga ttacaaaaaa tgagaatgaa     1380

gagtacaacc tcagtgggac aaagaagaac ttcagcagtc ttaaagatct tttgaattgt     1440

taccagatgg aaactgttcg ctcagacaat ataattttcc agtttactaa atgctgtccc     1500

ccaaagccaa aagataaatc aaaccttcta gtcttcagaa cgaatggtgt ttctgatgta     1560

ccaacctcac caacattaca gaggcctact catatgaacc aaatggtgtt tcacaaaatc     1620

agaaatgaag atttgatatt taatgaaagc cttggccaag gcacttttac aaagattttt     1680

aaaggcgtac gaagagaagt aggagactac ggtcaactgc atgaaacaga agttctttta     1740

aaagttctgg ataaagcaca cagaaactat tcagagtctt tctttgaagc agcaagtatg     1800

atgagcaagc tttctcacaa acatttggtt ttaaattatg gagtatgtgt ctgtggagac     1860

gagaatattc tggttcagga gtttgtaaaa tttggatcac tagatacata tctgaaaaag     1920

aataaaaatt gtataaatat attatggaaa cttgaagttg ctaaacagtt ggcatgggcc     1980

atgcattttc tagaagaaaa cacccttatt catgggaatg tatgtgccaa aaatattctg     2040

cttatcagag aagaagacag gaagacagga aatcctcctt tcatcaaact tagtgatcct     2100

ggcattagta ttacagtttt gccaaaggac attcttcagg agagaatacc atgggtacca     2160

cctgaatgca ttgaaaatcc taaaaattta aatttggcaa cagacaaatg gagttttggt     2220

accactttgt gggaaatctg cagtggagga gataaacctc taagtgctct ggattctcaa     2280

agaaagctac aattttatga agataggcat cagcttcctg caccaaagtg ggcagaatta     2340

gcaaacctta taaataattg tatggattat gaaccagatt tcaggccttc tttcagagcc     2400

atcatacgag atcttaacag tttgtttact ccagattatg aactattaac agaaaatgac     2460

atgttaccaa atatgaggat aggtgccctg gggttttctg gtgcctttga agaccgggat     2520

cctacacagt ttgaagagag acatttgaaa tttctacagc aacttggcaa gggtaatttt     2580

gggagtgtgg agatgtgccg gtatgaccct ctacaggaca acactgggga ggtggtcgct     2640

gtaaaaaagc ttcagcatag tactgaagag cacctaagag actttgaaag ggaaattgaa     2700

atcctgaaat ccctacagca tgacaacatt gtaaagtaca agggagtgtg ctacagtgct     2760

ggtcggcgta atctaaaatt aattatggaa tatttaccat atggaagttt acgagactat     2820

cttcaaaaac ataaagaacg gatagatcac ataaaacttc tgcagtacac atctcagata     2880

tgcaagggta tggagtatct tggtacaaaa aggtatatcc acagggatct ggcaacgaga     2940

aatatattgg tggagaacga gaacagagtt aaaattggag attttgggtt aaccaaagtc     3000

ttgccacaag acaaagaata ctataaagta aaagaacctg gtgaaagtcc catattctgg     3060

tatgctccag aatcactgac agagagcaag ttttctgtgg cctcagatgt ttggagcttt     3120

ggagtggttc tgtatgaact tttcacatac attgagaaga gtaaaagtcc accagcggaa     3180

tttatgcgta tgattggcaa tgacaaacaa ggacagatga tcgtgttcca tttgatagaa     3240

cttttgaaga ataatggaag attaccaaga ccagatggat gcccagatga gatctatatg     3300

atcatgacag aatgctggaa caataatgta aatcaacgcc cctcctttag ggatctagct     3360

cttcgagtgg atcaaataag ggataacatg gctggatga                            3399


<210>  8
<211>  3399
<212>  DNA
<213>  homo sapiens

<400>  8
atgggaatgg cctgccttac gatgacagaa atggagggaa catccacctc ttctatatat       60

cagaatggtg atatttctgg aaatgccaat tctatgaagc aaatagatcc agttcttcag      120

gtgtatcttt accattccct tgggaaatct gaggcagatt atctgacctt tccatctggg      180

gagtatgttg cagaagaaat ctgtattgct gcttctaaag cttgtggtat cacacctgtg      240

tatcataata tgtttgcttt aatgagtgaa acagaaagga tctggtatcc acccaaccat      300

gtcttccata tagatgagtc aaccaggcat aatgtactct acagaataag attttacttt      360

cctcgttggt attgcagtgg cagcaacaga gcctatcggc atggaatatc tcgaggtgct      420

gaagctcctc ttcttgatga ctttgtcatg tcttacctct ttgctcagtg gcggcatgat      480

tttgtgcacg gatggataaa agtacctgtg actcatgaaa cacaggaaga atgtcttggg      540

atggcagtgt tagatatgat gagaatagcc aaagaaaacg atcaaacccc actggccatc      600

tataactcta tcagctacaa gacattctta ccaaaatgta ttcgagcaaa gatccaagac      660

tatcatattt tgacaaggaa gcgaataagg tacagatttc gcagatttat tcagcaattc      720

agccaatgca aagccactgc cagaaacttg aaacttaagt atcttataaa tctggaaact      780

ctgcagtctg ccttctacac agagaaattt gaagtaaaag aacctggaag tggtccttca      840

ggtgaggaga tttttgcaac cattataata actggaaacg gtggaattca gtggtcaaga      900

gggaaacata aagaaagtga gacactgaca gaacaggatt tacagttata ttgcgatttt      960

cctaatatta ttgatgtcag tattaagcaa gcaaaccaag agggttcaaa tgaaagccga     1020

gttgtaacta tccataagca agatggtaaa aatctggaaa ttgaacttag ctcattaagg     1080

gaagctttgt ctttcgtgtc attaattgat ggatattata gattaactgc agatgcacat     1140

cattacctct gtaaagaagt agcacctcca gccgtgcttg aaaatataca aagcaactgt     1200

catggcccaa tttcgatgga ttttgccatt agtaaactga agaaagcagg taatcagact     1260

ggactgtatg tacttcgatg cagtcctaag gactttaata aatatttttt gacttttgct     1320

gtcgagcgag aaaatgtcat tgaatataaa cactgtttga ttacaaaaaa tgagaatgaa     1380

gagtacaacc tcagtgggac aaagaagaac ttcagcagtc ttaaagatct tttgaattgt     1440

taccagatgg aaactgttcg ctcagacaat ataattttcc agtttactaa atgctgtccc     1500

ccaaagccaa aagataaatc aaaccttcta gtcttcagaa cgaatggtgt ttctgatgta     1560

ccaacctcac caacattaca gaggcctact catatgaacc aaatggtgtt tcacaaaatc     1620

agaaatgaag atttgatatt taatgaaagc cttggccaag gcacttttac aaagattttt     1680

aaaggcgtac gaagagaagt aggagactac ggtcaactgc atgaaacaga agttctttta     1740

aaagttctgg ataaagcaca cagaaactat tcagagtctt tctttgaagc agcaagtatg     1800

atgagcaagc tttctcacaa gcatttggtt ttaaattatg gagtatgtgt ctgtggagac     1860

gagaatattc tggttcagga gtttgtaaaa tttggatcac tagatacata tctgaaaaag     1920

aataaaaatt gtataaatat attatggaaa cttgaagttg ctaaacagtt ggcatgggcc     1980

atgcattttc tagaagaaaa cacccttatt catgggaatg tatgtgccaa aaatattctg     2040

cttatcagag aagaagacag gaagacagga aatcctcctt tcatcaaact tagtgatcct     2100

ggcattagta ttacagtttt gccaaaggac attcttcagg agagaatacc atgggtacca     2160

cctgaatgca ttgaaaatcc taaaaattta aatttggcaa cagacaaatg gagttttggt     2220

accactttgt gggaaatctg cagtggagga gataaacctc taagagctct ggattctcaa     2280

agaaagctac aattttatga agataggcat cagcttcctg caccaaagtg ggcagaatta     2340

gcaaacctta taaataattg tatggattat gaaccagatt tcaggccttc tttcagagcc     2400

atcatacgag atcttaacag tttgtttact ccagattatg aactattaac agaaaatgac     2460

atgttaccaa atatgaggat aggtgccctg gggttttctg gtgcctttga agaccgggat     2520

cctacacagt ttgaagagag acatttgaaa tttctacagc aacttggcaa gggtaatttt     2580

gggagtgtgg agatgtgccg gtatgaccct ctacaggaca acactgggga ggtggtcgct     2640

gtaaaaaagc ttcagcatag tactgaagag cacctaagag actttgaaag ggaaattgaa     2700

atcctgaaat ccctacagca tgacaacatt gtaaagtaca agggagtgtg ctacagtgct     2760

ggtcggcgta atctaaaatt aattatggaa tatttaccat atggaagttt acgagactat     2820

cttcaaaaac ataaagaacg gatagatcac ataaaacttc tgcagtacac atctcagata     2880

tgcaagggta tggagtatct tggtacaaaa aggtatatcc acagggatct ggcaacgaga     2940

aatatattgg tggagaacga gaacagagtt aaaattggag attttgggtt aaccaaagtc     3000

ttgccacaag acaaagaata ctataaagta aaagaacctg gtgaaagtcc catattctgg     3060

tatgctccag aatcactgac agagagcaag ttttctgtgg cctcagatgt ttggagcttt     3120

ggagtggttc tgtatgaact tttcacatac attgagaaga gtaaaagtcc accagcggaa     3180

tttatgcgta tgattggcaa tgacaaacaa ggacagatga tcgtgttcca tttgatagaa     3240

cttttgaaga ataatggaag attaccaaga ccagatggat gcccagatga gatctatatg     3300

atcatgacag aatgctggaa caataatgta aatcaacgcc cctcctttag ggatctagct     3360

cttcgagtgg atcaaataag ggataacatg gctggatga                            3399


<210>  9
<211>  3399
<212>  DNA
<213>  homo sapiens

<400>  9
atgggaatgg cctgccttac gatgacagaa atggagggaa catccacctc ttctatatat       60

cagaatggtg atatttctgg aaatgccaat tctatgaagc aaatagatcc agttcttcag      120

gtgtatcttt accattccct tgggaaatct gaggcagatt atctgacctt tccatctggg      180

gagtatgttg cagaagaaat ctgtattgct gcttctaaag cttgtggtat cacacctgtg      240

tatcataata tgtttgcttt aatgagtgaa acagaaagga tctggtatcc acccaaccat      300

gtcttccata tagatgagtc aaccaggcat aatgtactct acagaataag attttacttt      360

cctcgttggt attgcagtgg cagcaacaga gcctatcggc atggaatatc tcgaggtgct      420

gaagctcctc ttcttgatga ctttgtcatg tcttacctct ttgctcagtg gcggcatgat      480

tttgtgcacg gatggataaa agtacctgtg actcatgaaa cacaggaaga atgtcttggg      540

atggcagtgt tagatatgat gagaatagcc aaagaaaacg atcaaacccc actggccatc      600

tataactcta tcagctacaa gacattctta ccaaaatgta ttcgagcaaa gatccaagac      660

tatcatattt tgacaaggaa gcgaataagg tacagatttc gcagatttat tcagcaattc      720

agccaatgca aagccactgc cagaaacttg aaacttaagt atcttataaa tctggaaact      780

ctgcagtctg ccttctacac agagaaattt gaagtaaaag aacctggaag tggtccttca      840

ggtgaggaga tttttgcaac cattataata actggaaacg gtggaattca gtggtcaaga      900

gggaaacata aagaaagtga gacactgaca gaacaggatt tacagttata ttgcgatttt      960

cctaatatta ttgatgtcag tattaagcaa gcaaaccaag agggttcaaa tgaaagccga     1020

gttgtaacta tccataagca agatggtaaa aatctggaaa ttgaacttag ctcattaagg     1080

gaagctttgt ctttcgtgtc attaattgat ggatattata gattaactgc agatgcacat     1140

cattacctct gtaaagaagt agcacctcca gccgtgcttg aaaatataca aagcaactgt     1200

catggcccaa tttcgatgga ttttgccatt agtaaactga agaaagcagg taatcagact     1260

ggactgtatg tacttcgatg cagtcctaag gactttaata aatatttttt gacttttgct     1320

gtcgagcgag aaaatgtcat tgaatataaa cactgtttga ttacaaaaaa tgagaatgaa     1380

gagtacaacc tcagtgggac aaagaagaac ttcagcagtc ttaaagatct tttgaattgt     1440

taccagatgg aaactgttcg ctcagacaat ataattttcc agtttactaa atgctgtccc     1500

ccaaagccaa aagataaatc aaaccttcta gtcttcagaa cgaatggtgt ttctgatgta     1560

ccaacctcac caacattaca gaggcctact catatgaacc aaatggtgtt tcacaaaatc     1620

agaaatgaag atttgatatt taatgaaagc cttggccaag gcacttttac aaagattttt     1680

aaaggcgtac gaagagaagt aggagactac ggtcaactgc atgaaacaga agttctttta     1740

aaagttctgg ataaagcaca cagaaactat tcagagtctt tctttgaagc agcaagtatg     1800

atgagcaagc tttctcacaa gcatttggtt ttaaattatg gagtatgtgt ctgtggagac     1860

gagaatattc tggttcagga gtttgtaaaa tttggatcac tagatacata tctgaaaaag     1920

aataaaaatt gtataaatat attatggaaa cttgaagttg ctaaacagtt ggcatgggcc     1980

atgcattttc tagaagaaaa cacccttatt catgggaatg tatgtgccaa aaatattctg     2040

cttatcagag aagaagacag gaagacagga aatcctcctt tcatcaaact tagtgatcct     2100

ggcattagta ttacagtttt gccaaaggac attcttcagg agagaatacc atgggtacca     2160

cctgaatgca ttgaaaatcc taaaaattta aatttggcaa cagacaaatg gagttttggt     2220

accactttgt gggaaatctg cagtggagga gataaacctc taagtgctct ggattctcaa     2280

agaaagctac aattttatga agataggcat cagcttcctg caccaaagtg ggcagaatta     2340

gcaaacctta taaataattg tatggattat gaaccagatt tcaggccttc tttcagagcc     2400

atcatacgag atcttaacag tttgtttact ccagattatg aactattaac agaaaatgac     2460

atgttaccaa atatgaggat aggtgccctg gggttttctg gtgcctttga agaccgggat     2520

cctacacagt ttgaagagag acatttgaaa tttctacagc aacttggcaa gggtaatttt     2580

gggagtgtgg agatgtgccg gtatgaccct ctacaggaca acactgggga ggtggtcgct     2640

gtaaaaaagc ttcagcatag tactgaagag cacctaagag actttgaaag ggaaattgaa     2700

atcctgaaat ccctacagca tgacaacatt gtaaagtaca agggagtgtg ctacagtgct     2760

ggtcggcgta atctaaaatt aattatggaa tatttaccat atggaagttt acaagactat     2820

cttcaaaaac ataaagaacg gatagatcac ataaaacttc tgcagtacac atctcagata     2880

tgcaagggta tggagtatct tggtacaaaa aggtatatcc acagggatct ggcaacgaga     2940

aatatattgg tggagaacga gaacagagtt aaaattggag attttgggtt aaccaaagtc     3000

ttgccacaag acaaagaata ctataaagta aaagaacctg gtgaaagtcc catattctgg     3060

tatgctccag aatcactgac agagagcaag ttttctgtgg cctcagatgt ttggagcttt     3120

ggagtggttc tgtatgaact tttcacatac attgagaaga gtaaaagtcc accagcggaa     3180

tttatgcgta tgattggcaa tgacaaacaa ggacagatga tcgtgttcca tttgatagaa     3240

cttttgaaga ataatggaag attaccaaga ccagatggat gcccagatga gatctatatg     3300

atcatgacag aatgctggaa caataatgta aatcaacgcc cctcctttag ggatctagct     3360

cttcgagtgg atcaaataag ggataacatg gctggatga                            3399


<210>  10
<211>  3399
<212>  DNA
<213>  homo sapiens

<400>  10
atgggaatgg cctgccttac gatgacagaa atggagggaa catccacctc ttctatatat       60

cagaatggtg atatttctgg aaatgccaat tctatgaagc aaatagatcc agttcttcag      120

gtgtatcttt accattccct tgggaaatct gaggcagatt atctgacctt tccatctggg      180

gagtatgttg cagaagaaat ctgtattgct gcttctaaag cttgtggtat cacacctgtg      240

tatcataata tgtttgcttt aatgagtgaa acagaaagga tctggtatcc acccaaccat      300

gtcttccata tagatgagtc aaccaggcat aatgtactct acagaataag attttacttt      360

cctcgttggt attgcagtgg cagcaacaga gcctatcggc atggaatatc tcgaggtgct      420

gaagctcctc ttcttgatga ctttgtcatg tcttacctct ttgctcagtg gcggcatgat      480

tttgtgcacg gatggataaa agtacctgtg actcatgaaa cacaggaaga atgtcttggg      540

atggcagtgt tagatatgat gagaatagcc aaagaaaacg atcaaacccc actggccatc      600

tataactcta tcagctacaa gacattctta ccaaaatgta ttcgagcaaa gatccaagac      660

tatcatattt tgacaaggaa gcgaataagg tacagatttc gcagatttat tcagcaattc      720

agccaatgca aagccactgc cagaaacttg aaacttaagt atcttataaa tctggaaact      780

ctgcagtctg ccttctacac agagaaattt gaagtaaaag aacctggaag tggtccttca      840

ggtgaggaga tttttgcaac cattataata actggaaacg gtggaattca gtggtcaaga      900

gggaaacata aagaaagtga gacactgaca gaacaggatt tacagttata ttgcgatttt      960

cctaatatta ttgatgtcag tattaagcaa gcaaaccaag agggttcaaa tgaaagccga     1020

gttgtaacta tccataagca agatggtaaa aatctggaaa ttgaacttag ctcattaagg     1080

gaagctttgt ctttcgtgtc attaattgat ggatattata gattaactgc agatgcacat     1140

cattacctct gtaaagaagt agcacctcca gccgtgcttg aaaatataca aagcaactgt     1200

catggcccaa tttcgatgga ttttgccatt agtaaactga agaaagcagg taatcagact     1260

ggactgtatg tacttcgatg cagtcctaag gactttaata aatatttttt gacttttgct     1320

gtcgagcgag aaaatgtcat tgaatataaa cactgtttga ttacaaaaaa tgagaatgaa     1380

gagtacaacc tcagtgggac aaagaagaac ttcagcagtc ttaaagatct tttgaattgt     1440

taccagatgg aaactgttcg ctcagacaat ataattttcc agtttactaa atgctgtccc     1500

ccaaagccaa aagataaatc aaaccttcta gtcttcagaa cgaatggtgt ttctgatgta     1560

ccaacctcac caacattaca gaggcctact catatgaacc aaatggtgtt tcacaaaatc     1620

agaaatgaag atttgatatt taatgaaagc cttggccaag gcacttttac aaagattttt     1680

aaaggcgtac gaagagaagt aggagactac ggtcaactgc atgaaacaga agttctttta     1740

aaagttctgg ataaagcaca cagaaactat tcagagtctt tctttgaagc agcaagtatg     1800

atgagcaagc tttctcacaa gcatttggtt ttaaattatg gagtatgtgt ctgtggagac     1860

gagaatattc tggttcagga gtttgtaaaa tttggatcac tagatacata tctgaaaaag     1920

aataaaaatt gtataaatat attatggaaa cttgaagttg ctaaacagtt ggcatgggcc     1980

atgcattttc tagaagaaaa cacccttatt catgggaatg tatgtgccaa aaatattctg     2040

cttatcagag aagaagacag gaagacagga aatcctcctt tcatcaaact tagtgatcct     2100

ggcattagta ttacagtttt gccaaaggac attcttcagg agagaatacc atgggtacca     2160

cctgaatgca ttgaaaatcc taaaaattta aatttggcaa cagacaaatg gagttttggt     2220

accactttgt gggaaatctg cagtggagga gataaacctc taagtgctct ggattctcaa     2280

agaaagctac aattttatga agataggcat cagcttcctg caccaaagtg ggcagaatta     2340

gcaaacctta taaataattg tatggattat gaaccagatt tcaggccttc tttcagagcc     2400

atcatacgag atcttaacag tttgtttact ccagattatg aactattaac agaaaatgac     2460

atgttaccaa atatgaggat aggtgccctg gggttttctg gtgcctttga agaccgggat     2520

cctacacagt ttgaagagag acatttgaaa tttctacagc aacttggcaa gggtaatttt     2580

gggagtgtgg agatgtgcca gtatgaccct ctacaggaca acactgggga ggtggtcgct     2640

gtaaaaaagc ttcagcatag tactgaagag cacctaagag actttgaaag ggaaattgaa     2700

atcctgaaat ccctacagca tgacaacatt gtaaagtaca agggagtgtg ctacagtgct     2760

ggtcggcgta atctaaaatt aattatggaa tatttaccat atggaagttt acgagactat     2820

cttcaaaaac ataaagaacg gatagatcac ataaaacttc tgcagtacac atctcagata     2880

tgcaagggta tggagtatct tggtacaaaa aggtatatcc acagggatct ggcaacgaga     2940

aatatattgg tggagaacga gaacagagtt aaaattggag attttgggtt aaccaaagtc     3000

ttgccacaag acaaagaata ctataaagta aaagaacctg gtgaaagtcc catattctgg     3060

tatgctccag aatcactgac agagagcaag ttttctgtgg cctcagatgt ttggagcttt     3120

ggagtggttc tgtatgaact tttcacatac attgagaaga gtaaaagtcc accagcggaa     3180

tttatgcgta tgattggcaa tgacaaacaa ggacagatga tcgtgttcca tttgatagaa     3240

cttttgaaga ataatggaag attaccaaga ccagatggat gcccagatga gatctatatg     3300

atcatgacag aatgctggaa caataatgta aatcaacgcc cctcctttag ggatctagct     3360

cttcgagtgg atcaaataag ggataacatg gctggatga                            3399


<210>  11
<211>  3399
<212>  DNA
<213>  homo sapiens

<400>  11
atgggaatgg cctgccttac gatgacagaa atggagggaa catccacctc ttctatatat       60

cagaatggtg atatttctgg aaatgccaat tctatgaagc aaatagatcc agttcttcag      120

gtgtatcttt accattccct tgggaaatct gaggcagatt atctgacctt tccatctggg      180

gagtatgttg cagaagaaat ctgtattgct gcttctaaag cttgtggtat cacacctgtg      240

tatcataata tgtttgcttt aatgagtgaa acagaaagga tctggtatcc acccaaccat      300

gtcttccata tagatgagtc aaccaggcat aatgtactct acagaataag attttacttt      360

cctcgttggt attgcagtgg cagcaacaga gcctatcggc atggaatatc tcgaggtgct      420

gaagctcctc ttcttgatga ctttgtcatg tcttacctct ttgctcagtg gcggcatgat      480

tttgtgcacg gatggataaa agtacctgtg actcatgaaa cacaggaaga atgtcttggg      540

atggcagtgt tagatatgat gagaatagcc aaagaaaacg atcaaacccc actggccatc      600

tataactcta tcagctacaa gacattctta ccaaaatgta ttcgagcaaa gatccaagac      660

tatcatattt tgacaaggaa gcgaataagg tacagatttc gcagatttat tcagcaattc      720

agccaatgca aagccactgc cagaaacttg aaacttaagt atcttataaa tctggaaact      780

ctgcagtctg ccttctacac agagaaattt gaagtaaaag aacctggaag tggtccttca      840

ggtgaggaga tttttgcaac cattataata actggaaacg gtggaattca gtggtcaaga      900

gggaaacata aagaaagtga gacactgaca gaacaggatt tacagttata ttgcgatttt      960

cctaatatta ttgatgtcag tattaagcaa gcaaaccaag agggttcaaa tgaaagccga     1020

gttgtaacta tccataagca agatggtaaa aatctggaaa ttgaacttag ctcattaagg     1080

gaagctttgt ctttcgtgtc attaattgat ggatattata gattaactgc agatgcacat     1140

cattacctct gtaaagaagt agcacctcca gccgtgcttg aaaatataca aagcaactgt     1200

catggcccaa tttcgatgga ttttgccatt agtaaactga agaaagcagg taatcagact     1260

ggactgtatg tacttcgatg cagtcctaag gactttaata aatatttttt gacttttgct     1320

gtcgagcgag aaaatgtcat tgaatataaa cactgtttga ttacaaaaaa tgagaatgaa     1380

gagtacaacc tcagtgggac aaagaagaac ttcagcagtc ttaaagatct tttgaattgt     1440

taccagatgg aaactgttcg ctcagacaat ataattttcc agtttactaa atgctgtccc     1500

ccaaagccaa aagataaatc aaaccttcta gtcttcagaa cgaatggtgt ttctgatgta     1560

ccaacctcac caacattaca gaggcctact catatgaacc aaatggtgtt tcacaaaatc     1620

agaaatgaag atttgatatt taatgaaagc cttggccaag gcacttttac aaagattttt     1680

aaaggcgtac gaagagaagt aggagactac ggtcaactgc atgaaacaga agttctttta     1740

aaagttctgg ataaagcaca cagaaactat tcagagtctt tctttgaagc agcaagtatg     1800

atgagcaagc tttctcacaa gcatttggtt ttaaattatg gagtatgtgt ctgtggagac     1860

gagaatattc tggttcagga gtttgtaaaa tttggatcac tagatacata tctgaaaaag     1920

aataaaaatt gtataaatat attatggaaa cttgaagttg ctaaacagtt ggcatgggcc     1980

atgcattttc tagaagaaaa cacccttatt catgggaatg tatgtgccaa aaatattctg     2040

cttatcagag aagaagacag gaagacagga aatcctcctt tcatcaaact tagtgatcct     2100

ggcattagta ttacagtttt gccaaaggac attcttcagg agagaatacc atgggtacca     2160

cctgaatgca ttgaaaatcc taaaaattta aatttggcaa cagacaaatg gagttttggt     2220

accactttgt gggaaatctg cagtggagga gataaacctc taagagctct ggattctcaa     2280

agaaagctac aattttatga agataggcat cagcttcctg caccaaagtg ggcagaatta     2340

gcaaacctta taaataattg tatggattat gaaccagatt tcaggccttc tttcagagcc     2400

atcatacgag atcttaacag tttgtttact ccagattatg aactattaac agaaaatgac     2460

atgttaccaa atatgaggat aggtgccctg gggttttctg gtgcctttga agaccgggat     2520

cctacacagt ttgaagagag acatttgaaa tttctacagc aacttggcaa gggtaatttt     2580

gggagtgtgg agatgtgccg gtatgaccct ctacaggaca acactgggga ggtggtcgct     2640

gtaaaaaagc ttcagcatag tactgaagag cacctaagag actttgaaag ggaaattgaa     2700

atcctgaaat ccctacagca tgacaacatt gtaaagtaca agggagtgtg ctacagtgct     2760

ggtcggcgta atctaaaatt aattatggaa tatttaccat atggaagttt acaagactat     2820

cttcaaaaac ataaagaacg gatagatcac ataaaacttc tgcagtacac atctcagata     2880

tgcaagggta tggagtatct tggtacaaaa aggtatatcc acagggatct ggcaacgaga     2940

aatatattgg tggagaacga gaacagagtt aaaattggag attttgggtt aaccaaagtc     3000

ttgccacaag acaaagaata ctataaagta aaagaacctg gtgaaagtcc catattctgg     3060

tatgctccag aatcactgac agagagcaag ttttctgtgg cctcagatgt ttggagcttt     3120

ggagtggttc tgtatgaact tttcacatac attgagaaga gtaaaagtcc accagcggaa     3180

tttatgcgta tgattggcaa tgacaaacaa ggacagatga tcgtgttcca tttgatagaa     3240

cttttgaaga ataatggaag attaccaaga ccagatggat gcccagatga gatctatatg     3300

atcatgacag aatgctggaa caataatgta aatcaacgcc cctcctttag ggatctagct     3360

cttcgagtgg atcaaataag ggataacatg gctggatga                            3399


<210>  12
<211>  3399
<212>  DNA
<213>  homo sapiens

<400>  12
atgggaatgg cctgccttac gatgacagaa atggagggaa catccacctc ttctatatat       60

cagaatggtg atatttctgg aaatgccaat tctatgaagc aaatagatcc agttcttcag      120

gtgtatcttt accattccct tgggaaatct gaggcagatt atctgacctt tccatctggg      180

gagtatgttg cagaagaaat ctgtattgct gcttctaaag cttgtggtat cacacctgtg      240

tatcataata tgtttgcttt aatgagtgaa acagaaagga tctggtatcc acccaaccat      300

gtcttccata tagatgagtc aaccaggcat aatgtactct acagaataag attttacttt      360

cctcgttggt attgcagtgg cagcaacaga gcctatcggc atggaatatc tcgaggtgct      420

gaagctcctc ttcttgatga ctttgtcatg tcttacctct ttgctcagtg gcggcatgat      480

tttgtgcacg gatggataaa agtacctgtg actcatgaaa cacaggaaga atgtcttggg      540

atggcagtgt tagatatgat gagaatagcc aaagaaaacg atcaaacccc actggccatc      600

tataactcta tcagctacaa gacattctta ccaaaatgta ttcgagcaaa gatccaagac      660

tatcatattt tgacaaggaa gcgaataagg tacagatttc gcagatttat tcagcaattc      720

agccaatgca aagccactgc cagaaacttg aaacttaagt atcttataaa tctggaaact      780

ctgcagtctg ccttctacac agagaaattt gaagtaaaag aacctggaag tggtccttca      840

ggtgaggaga tttttgcaac cattataata actggaaacg gtggaattca gtggtcaaga      900

gggaaacata aagaaagtga gacactgaca gaacaggatt tacagttata ttgcgatttt      960

cctaatatta ttgatgtcag tattaagcaa gcaaaccaag agggttcaaa tgaaagccga     1020

gttgtaacta tccataagca agatggtaaa aatctggaaa ttgaacttag ctcattaagg     1080

gaagctttgt ctttcgtgtc attaattgat ggatattata gattaactgc agatgcacat     1140

cattacctct gtaaagaagt agcacctcca gccgtgcttg aaaatataca aagcaactgt     1200

catggcccaa tttcgatgga ttttgccatt agtaaactga agaaagcagg taatcagact     1260

ggactgtatg tacttcgatg cagtcctaag gactttaata aatatttttt gacttttgct     1320

gtcgagcgag aaaatgtcat tgaatataaa cactgtttga ttacaaaaaa tgagaatgaa     1380

gagtacaacc tcagtgggac aaagaagaac ttcagcagtc ttaaagatct tttgaattgt     1440

taccagatgg aaactgttcg ctcagacaat ataattttcc agtttactaa atgctgtccc     1500

ccaaagccaa aagataaatc aaaccttcta gtcttcagaa cgaatggtgt ttctgatgta     1560

ccaacctcac caacattaca gaggcctact catatgaacc aaatggtgtt tcacaaaatc     1620

agaaatgaag atttgatatt taatgaaagc cttggccaag gcacttttac aaagattttt     1680

aaaggcgtac gaagagaagt aggagactac ggtcaactgc atgaaacaga agttctttta     1740

aaagttctgg ataaagcaca cagaaactat tcagagtctt tctttgaagc agcaagtatg     1800

atgagcaagc tttctcacaa gcatttggtt ttaaattatg gagtatgttt ctgtggagac     1860

gagaatattc tggttcagga gtttgtaaaa tttggatcac tagatacata tctgaaaaag     1920

aataaaaatt gtataaatat attatggaaa cttgaagttg ctaaacagtt ggcatgggcc     1980

atgcattttc tagaagaaaa cacccttatt catgggaatg tatgtgccaa aaatattctg     2040

cttatcagag aagaagacag gaagacagga aatcctcctt tcatcaaact tagtgatcct     2100

ggcattagta ttacagtttt gccaaaggac attcttcagg agagaatacc atgggtacca     2160

cctgaatgca ttgaaaatcc taaaaattta aatttggcaa cagacaaatg gagttttggt     2220

accactttgt gggaaatctg cagtggagga gataaacctc taagtgctct ggattctcaa     2280

agaaagctac aattttatga agataggcat cagcttcctg caccaaagtg ggcagaatta     2340

gcaaacctta taaataattg tatggattat gaaccagatt tcaggccttc tttcagagcc     2400

atcatacgag atcttaacag tttgtttact ccagattatg aactattaac agaaaatgac     2460

atgttaccaa atatgaggat aggtgccctg gggttttctg gtgcctttga agaccgggat     2520

cctacacagt ttgaagagag acatttgaaa tttctacagc aacttggcaa gggtaatttt     2580

gggagtgtgg agatgtgccg gtatgaccct ctacaggaca acactgggga ggtggtcgct     2640

gtaaaaaagc ttcagcatag tactgaagag cacctaagag actttgaaag ggaaattgaa     2700

atcctgaaat ccctacagca tgacaacatt gtaaagtaca agggagtgtg ctacagtgct     2760

ggtcggcgta atctaaaatt aattatggaa tatttaccat atggaagttt acgagactat     2820

cttcaaaaac ataaagaacg gatagatcac ataaaacttc tgcagtacac atctcagata     2880

tgcaagggta tggagtatct tggtacaaaa aggtatatcc acagggatct ggcaacgaga     2940

aatatattgg tggagaacga gaacagagtt aaaattggag attttgggtt aaccaaagtc     3000

ttgccacaag acaaagaata ctataaagta aaagaacctg gtgaaagtcc catattctgg     3060

tatgctccag aatcactgac agagagcaag ttttctgtgg cctcagatgt ttggagcttt     3120

ggagtggttc tgtatgaact tttcacatac attgagaaga gtaaaagtcc accagcggaa     3180

tttatgcgta tgattggcaa tgacaaacaa ggacagatga tcgtgttcca tttgatagaa     3240

cttttgaaga ataatggaag attaccaaga ccagatggat gcccagatga gatctatatg     3300

atcatgacag aatgctggaa caataatgta aatcaacgcc cctcctttag ggatctagct     3360

cttcgagtgg atcaaataag ggataacatg gctggatga                            3399


<210>  13
<211>  1132
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Pro Ala His Gln Asn Gly Asp Ile Pro Gly Asn Ala Asn Ser Val 
            20                  25                  30          


Lys Gln Thr Glu Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Gln Ala Glu Gly Asp Tyr Leu Lys Phe Pro Asn Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Val Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Ile 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro His Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Thr Tyr Arg Tyr Gly Val Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Lys Asp Gln Thr Pro Leu Ala Val Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Val Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Gln Phe Glu Val 
            260                 265                 270         


Lys Glu Ser Ala Arg Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asp Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Cys Ser 
                325                 330                 335     


Thr Glu Ser Arg Val Val Thr Val His Lys Gln Asp Gly Lys Val Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Lys Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile His Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Gly Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Arg Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Ser Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Gln Leu Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


His Asn Asn Val Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Gln Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Glu Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Ser Ile Asn Ile Leu Trp Lys Leu Gly Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Lys Ser Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Thr Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Lys His Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Thr Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ala Phe Arg Ala 
785                 790                 795                 800 


Val Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Arg Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Lys Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Val Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Glu Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Val  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ser  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Ser Met  Ala Ala 
    1130         


<210>  14
<211>  1132
<212>  PRT
<213>  Mus musculus

<400>  14

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Ala Thr Ser Thr 
1               5                   10                  15      


Ser Pro Val His Gln Asn Gly Asp Ile Pro Gly Ser Ala Asn Ser Val 
            20                  25                  30          


Lys Gln Ile Glu Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Gln Ala Glu Gly Glu Tyr Leu Lys Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Val Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asp Ile 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro His Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Ser Arg Thr Tyr Arg Tyr Gly Val Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Lys Asp Gln Thr Pro Leu Ala Val Tyr Asn Ser Val Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Val Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Gln Phe Glu Val 
            260                 265                 270         


Lys Glu Ser Ala Arg Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Val Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asp Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Cys Ser 
                325                 330                 335     


Asn Glu Ser Arg Ile Val Thr Val His Lys Gln Asp Gly Lys Val Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Lys Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile His Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Gly Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Arg Asn Phe Ser Asn Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Ser Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Ile Ser Asp Val Gln Ile Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


His Asn Asn Val Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Lys Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Gln Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Glu Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Ser Ile Asn Ile Leu Trp Lys Leu Gly Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Lys Ser Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Arg 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Lys His Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ala Phe Arg Ala 
785                 790                 795                 800 


Val Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Arg Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Lys Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Val Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Ser Asn  Gly Arg Leu Pro Arg  Pro Glu Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Val  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Ser Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ser  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Ser Ile  Ala Ala 
    1130         


<210>  15
<211>  48
<212>  DNA
<213>  artificial

<220>
<223>  Primer JAK2 755R

<400>  15
gcagtggagg agataaacct ctaagagctc tggattctca aagaaagc                    48


<210>  16
<211>  48
<212>  DNA
<213>  artificial

<220>
<223>  Primer JAK2 755R

<400>  16
gctttctttg agaatccaga gctcttagag gtttatctcc tccactgc                    48


<210>  17
<211>  55
<212>  DNA
<213>  artificial

<220>
<223>  Primer JAK2 938R

<400>  17
ggaatattta ccatatggaa gtttacaaga ctatcttcaa aaacataaag aacgg            55


<210>  18
<211>  55
<212>  DNA
<213>  artificial

<220>
<223>  Primer JAK2 938R

<400>  18
ccgttcttta tgtttttgaa gatagtcttg taaacttcca tatggtaaat attcc            55


<210>  19
<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  Primer JAK2 867R

<400>  19
gggagtgtgg agatgtgcca gtatgaccct ctacaggaca acactgg                     47


<210>  20
<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  Primer JAK2 867R

<400>  20
ccagtgttgt cctgtagagg gtcatactgg cacatctcca cactccc                     47


<210>  21
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Primer JAK2 755R

<400>  21
ggaaacttga agttgctaaa cagttgg                                           27


<210>  22
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Primer JAK2 755R

<400>  22
ggcctgaaat ctggttcat                                                    19


<210>  23
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Primers JAK2 938R and 867R

<400>  23
gaggataggt gccctaggg                                                    19


<210>  24
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Primers JAK2 938R and 867R

<400>  24
ctcgttgcca gatccctgtg g                                                 21


