                         SEQUENCE LISTING

<110>  Suppremol GmbH
 
<120>  Novel Fc gamma receptor IIB variants

<130>  SUP14715PCT

<150>  US13/663,527
<151>  2012-10-30

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  177
<212>  PRT
<213>  artificial

<220>
<223>  Fc gamma receptor IIB variant

<400>  1

Met Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn 
1               5                   10                  15      


Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser 
            20                  25                  30          


Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro 
        35                  40                  45              


Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser 
    50                  55                  60                  


Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val 
65                  70                  75                  80  


His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu 
                85                  90                  95      


Glu Phe Gln Glu Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys 
            100                 105                 110         


Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys 
        115                 120                 125             


Lys Phe Ser Arg Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His 
    130                 135                 140                 


Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu 
145                 150                 155                 160 


Tyr Ser Ser Lys Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser 
                165                 170                 175     


Pro 
    


<210>  2
<211>  176
<212>  PRT
<213>  artificial

<220>
<223>  Fc gamma receptor IIB variant

<400>  2

Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val 
1               5                   10                  15      


Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro 
            20                  25                  30          


Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr 
        35                  40                  45              


His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly 
    50                  55                  60                  


Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His 
65                  70                  75                  80  


Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu 
                85                  90                  95      


Phe Gln Glu Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp 
            100                 105                 110         


Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys 
        115                 120                 125             


Phe Ser Arg Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser 
    130                 135                 140                 


His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr 
145                 150                 155                 160 


Ser Ser Lys Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro 
                165                 170                 175     


<210>  3
<211>  175
<212>  PRT
<213>  artificial

<220>
<223>  Fc gamma receptor IIB variant

<400>  3

Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu 
1               5                   10                  15      


Gln Glu Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu 
            20                  25                  30          


Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His 
        35                  40                  45              


Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu 
    50                  55                  60                  


Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu 
65                  70                  75                  80  


Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe 
                85                  90                  95      


Gln Glu Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys 
            100                 105                 110         


Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe 
        115                 120                 125             


Ser Arg Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His 
    130                 135                 140                 


Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser 
145                 150                 155                 160 


Ser Lys Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro 
                165                 170                 175 


<210>  4
<211>  174
<212>  PRT
<213>  artificial

<220>
<223>  Fc gamma receptor IIB variant

<400>  4

Pro Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln 
1               5                   10                  15      


Glu Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser 
            20                  25                  30          


Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr 
        35                  40                  45              


Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr 
    50                  55                  60                  


Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr 
65                  70                  75                  80  


Val Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln 
                85                  90                  95      


Glu Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro 
            100                 105                 110         


Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser 
        115                 120                 125             


Arg Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser 
    130                 135                 140                 


Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser 
145                 150                 155                 160 


Lys Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro 
                165                 170                 


<210>  5
<211>  172
<212>  PRT
<213>  artificial

<220>
<223>  Fc gamma receptor IIB variant

<400>  5

Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu Asp 
1               5                   10                  15      


Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp Ser 
            20                  25                  30          


Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln Pro 
        35                  40                  45              


Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr Cys 
    50                  55                  60                  


Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val Leu 
65                  70                  75                  80  


Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu Gly 
                85                  90                  95      


Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu Val 
            100                 105                 110         


Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg Ser 
        115                 120                 125             


Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly Asp 
    130                 135                 140                 


Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys Pro 
145                 150                 155                 160 


Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro 
                165                 170         


<210>  6
<211>  534
<212>  DNA
<213>  artificial

<220>
<223>  Fc gamma receptor IIB variant

<400>  6
atggcaccgc cgaaagcagt tctgaaactg gaaccgcagt ggattaacgt tctgcaggaa       60

gatagcgtta ccctgacctg tcgtggcacc catagcccgg aaagcgatag cattcagtgg      120

tttcacaacg gcaatctgat tccgacccat acccagccga gctatcgttt taaagcgaac      180

aacaacgata gcggcgaata tacctgtcag accggtcaga ccagcctgag cgatccggtt      240

catctgaccg ttctgagcga atggctggtt ctgcagaccc cgcatctgga atttcaggaa      300

ggcgaaacca ttgttctgcg ttgccacagc tggaaagata aaccgctggt taaagttacc      360

ttcttccaga acggcaaaag caaaaaattc agccgtagcg atccgaattt tagcattccg      420

caggcgaatc atagccatag cggcgattat cattgtaccg gcaacattgg ctataccctg      480

tatagcagca aaccggtgac cattaccgtt caggcgccga gcagcagccc gtaa            534


<210>  7
<211>  166
<212>  PRT
<213>  artificial

<220>
<223>  Fc gamma receptor IIB variant

<400>  7

Met Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
1               5                   10                  15      


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
            20                  25                  30          


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
        35                  40                  45              


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
    50                  55                  60                  


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
65                  70                  75                  80  


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
                85                  90                  95      


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
            100                 105                 110         


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
        115                 120                 125             


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
    130                 135                 140                 


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
145                 150                 155                 160 


Pro Val Thr Ile Thr Val 
                165     


<210>  8
<211>  185
<212>  PRT
<213>  artificial

<220>
<223>  Fc gamma receptor IIB variant

<400>  8

Met Gly Thr Pro Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro 
1               5                   10                  15      


Gln Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Arg 
            20                  25                  30          


Gly Thr His Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly 
        35                  40                  45              


Asn Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn 
    50                  55                  60                  


Asn Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu 
65                  70                  75                  80  


Ser Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln 
                85                  90                  95      


Thr Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Val Leu Arg Cys 
            100                 105                 110         


His Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn 
        115                 120                 125             


Gly Lys Ser Lys Lys Phe Ser Arg Ser Asp Pro Asn Phe Ser Ile Pro 
    130                 135                 140                 


Gln Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile 
145                 150                 155                 160 


Gly Tyr Thr Leu Tyr Ser Ser Lys Pro Val Thr Ile Thr Val Gln Ala 
                165                 170                 175     


Pro Ser Ser Ser Pro Met Gly Ile Ile 
            180                 185 


<210>  9
<211>  183
<212>  PRT
<213>  artificial

<220>
<223>  Fc gamma receptor IIB variant

<400>  9

Met Thr Pro Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Gln 
1               5                   10                  15      


Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Arg Gly 
            20                  25                  30          


Thr His Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
        35                  40                  45              


Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
    50                  55                  60                  


Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
65                  70                  75                  80  


Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
                85                  90                  95      


Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Val Leu Arg Cys His 
            100                 105                 110         


Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
        115                 120                 125             


Lys Ser Lys Lys Phe Ser Arg Ser Asp Pro Asn Phe Ser Ile Pro Gln 
    130                 135                 140                 


Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
145                 150                 155                 160 


Tyr Thr Leu Tyr Ser Ser Lys Pro Val Thr Ile Thr Val Gln Ala Pro 
                165                 170                 175     


Ser Ser Ser Pro Met Gly Ile 
            180             


