                         SEQUENCE LISTING

<110>  CO2 Solutions Inc.
 
<120>  TECHNIQUES FOR CO2 CAPTURE USING SULFURIHYDROGENIBIUM SP. 
       CARBONIC ANHYDRASE

<130>  00677-0175

<150>  US 61/719,710
<151>  2012-10-29

<160>  208   

<170>  PatentIn version 3.5

<210>  1
<211>  741
<212>  DNA
<213>  SULFURIHYDROGENIBIUM SP.

<400>  1
atgagaaaaa tactaatttc tgcagtttta gtattatcaa gcatttctat atcttttgct       60

gagcatgaat ggagttatga aggtgaaaag ggaccggagc attgggcgca gttaaaacct      120

gaattctttt ggtgtaaatt aaaaaatcaa tctcctataa acattgataa aaaatataaa      180

gttaaagcaa acctgccaaa gttaaacttg tactacaaaa ctgcaaaaga atcagaagta      240

gtaaacaatg gtcatactat tcagataaat ataaaagaag ataacacttt aaactacctt      300

ggagaaaagt atcagcttaa acagtttcat ttccacacac caagtgaaca tacaatagag      360

aaaaaatctt atccgttgga aattcacttt gttcataaaa cagaagatgg taagattttg      420

gtcgttggtg taatggctaa acttgggaaa actaataaag agttagataa aattttaaac      480

gttgctcctg ctgaagaagg agaaaaaatt cttgataaga atttaaattt aaacaatctt      540

ataccaaaag ataagagata tatgacatac tcaggctcat taaccactcc accatgcact      600

gaaggtgtaa gatggattgt cttgaaaaaa cctatttcta tatctaagca gcaacttgaa      660

aagttaaaat ctgttatggt gaatcctaac aacagacctg ttcaagagat taattcaaga      720

tggataattg aaggatttta a                                                741


<210>  2
<211>  246
<212>  PRT
<213>  SULFURIHYDROGENIBIUM SP.

<400>  2

Met Arg Lys Ile Leu Ile Ser Ala Val Leu Val Leu Ser Ser Ile Ser 
1               5                   10                  15      


Ile Ser Phe Ala Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro 
            20                  25                  30          


Glu His Trp Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys 
        35                  40                  45              


Asn Gln Ser Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn 
    50                  55                  60                  


Leu Pro Lys Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val 
65                  70                  75                  80  


Val Asn Asn Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr 
                85                  90                  95      


Leu Asn Tyr Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His 
            100                 105                 110         


Thr Pro Ser Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile 
        115                 120                 125             


His Phe Val His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val 
    130                 135                 140                 


Met Ala Lys Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn 
145                 150                 155                 160 


Val Ala Pro Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn 
                165                 170                 175     


Leu Asn Asn Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly 
            180                 185                 190         


Ser Leu Thr Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu 
        195                 200                 205             


Lys Lys Pro Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser 
    210                 215                 220                 


Val Met Val Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg 
225                 230                 235                 240 


Trp Ile Ile Glu Gly Phe 
                245     


<210>  3

<400>  3
000

<210>  4

<400>  4
000

<210>  5

<400>  5
000

<210>  6

<400>  6
000

<210>  7
<211>  684
<212>  DNA
<213>  Sulfurihydrogenibium sp.

<400>  7
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  8
<211>  227
<212>  PRT
<213>  Sulfurihydrogenibium sp.

<400>  8

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  9
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18A

<400>  9
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc ggctttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  10
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18A

<400>  10

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Ala Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  11
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18C

<400>  11
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gtgtttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  12
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18C

<400>  12

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Cys Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  13
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18F

<400>  13
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gtttttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  14
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18F

<400>  14

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Phe Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  15
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18L

<400>  15
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcttttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  16
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18L

<400>  16

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Leu Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  17
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18R

<400>  17
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcgtttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  18
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18R

<400>  18

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Arg Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  19
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18S

<400>  19
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gtctttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  20
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18S

<400>  20

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Ser Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  21
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18W

<400>  21
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gtggttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  22
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18W

<400>  22

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Trp Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  23
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K20A

<400>  23
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttggct       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  24
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K20A

<400>  24

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Ala Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  25
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K20G

<400>  25
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgggt       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  26
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K20G

<400>  26

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Gly Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  27
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K20L

<400>  27
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgctt       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  28
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K20L

<400>  28

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Leu Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  29
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K20N

<400>  29
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaat       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  30
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K20N

<400>  30

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Asn Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  31
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K20R

<400>  31
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgcgt       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  32
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K20R

<400>  32

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Arg Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  33
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K20S

<400>  33
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgtct       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  34
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K20S

<400>  34

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Ser Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  35
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K20T

<400>  35
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgact       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  36
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K20T

<400>  36

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Thr Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  37
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38A

<400>  37
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga cgctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  38
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38A

<400>  38

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ala Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  39
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38C

<400>  39
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctgtaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  40
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38C

<400>  40

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Cys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  41
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38D

<400>  41
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga cgataagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  42
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38D

<400>  42

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Asp Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  43
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38G

<400>  43
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga cggtaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  44
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38G

<400>  44

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Gly Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  45
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38L

<400>  45
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ccttaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  46
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38L

<400>  46

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Leu Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  47
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38N

<400>  47
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caataagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  48
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38N

<400>  48

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Asn Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  49
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38P

<400>  49
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ccctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  50
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38P

<400>  50

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Pro Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  51
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38R

<400>  51
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ccgtaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  52
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38R

<400>  52

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Arg Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  53
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38S

<400>  53
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  54
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38S

<400>  54

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  55
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38W

<400>  55
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctggaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  56
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38W

<400>  56

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Trp Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  57
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Y52C

<400>  57
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtgttaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  58
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Y52C

<400>  58

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Cys Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  59
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Y52E

<400>  59
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctggagtaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  60
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Y52E

<400>  60

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Glu Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  61
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Y52G

<400>  61
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgggttaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  62
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Y52G

<400>  62

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Gly Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  63
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Y52P

<400>  63
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgccttaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  64
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Y52P

<400>  64

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Pro Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  65
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Y52T

<400>  65
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgacttaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  66
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Y52T

<400>  66

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Thr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  67
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K57A

<400>  67
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcagc tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  68
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K57A

<400>  68

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Ala Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  69
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K57G

<400>  69
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcagg tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  70
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K57G

<400>  70

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Gly Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  71
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K57L

<400>  71
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  72
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K57L

<400>  72

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  73
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K57N

<400>  73
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  74
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K57N

<400>  74

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Asn Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  75
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K57P

<400>  75
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcacc tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  76
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K57P

<400>  76

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Pro Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  77
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K57R

<400>  77
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcacg tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  78
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K57R

<400>  78

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Arg Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  79
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K57S

<400>  79
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcatc tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  80
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K57S

<400>  80

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Ser Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  81
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K57V

<400>  81
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcagt tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  82
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K57V

<400>  82

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Val Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  83
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G82C

<400>  83
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  84
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G82C

<400>  84

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  85
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G82E

<400>  85
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctggaggaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  86
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G82E

<400>  86

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Glu Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  87
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: I100A

<400>  87
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgct      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  88
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: I100A

<400>  88

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ala Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  89
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: I100E

<400>  89
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgag      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  90
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: I100E

<400>  90

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Glu Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  91
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: I100N

<400>  91
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccaat      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  92
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: I100N

<400>  92

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Asn Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  93
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: I100S

<400>  93
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcatacctct      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  94
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: I100S

<400>  94

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ser Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  95
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: I100V

<400>  95
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  96
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: I100V

<400>  96

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  97
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: I100Y

<400>  97
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcatacctat      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  98
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: I100Y

<400>  98

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Tyr Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  99
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: E116D

<400>  99
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgatga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  100
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: E116D

<400>  100

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Asp Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  101
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G130A

<400>  101
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactggct aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  102
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G130A

<400>  102

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Ala Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  103
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G130C

<400>  103
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgtgt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  104
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G130C

<400>  104

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Cys Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  105
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G130L

<400>  105
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgctt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  106
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G130L

<400>  106

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Leu Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  107
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K150A

<400>  107
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaagct atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  108
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K150A

<400>  108

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Ala Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  109
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K150S

<400>  109
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaatct atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  110
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K150S

<400>  110

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Ser Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  111
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: N155I

<400>  111
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaatcctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  112
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: N155I

<400>  112

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Ile Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  113
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: T181L

<400>  113
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

cttgaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  114
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: T181L

<400>  114

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Leu Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  115
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: T181Q

<400>  115
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

caggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  116
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: T181Q

<400>  116

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Gln Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  117
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: T181R

<400>  117
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

cgtgaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  118
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: T181R

<400>  118

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Arg Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  119
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: S205C

<400>  119
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aatgtgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  120
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: S205C

<400>  120

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Cys Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  121
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18T-K20A

<400>  121
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gactttggct       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  122
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18T-K20A

<400>  122

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Thr Leu Ala Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  123
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18R-K20A

<400>  123
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcgtttggct       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  124
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18R-K20A

<400>  124

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Arg Leu Ala Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  125
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: E2K-T181M-K197I

<400>  125
atgaagcacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

atggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcat ccagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  126
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: E2K-T181M-K197I

<400>  126

Met Lys His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Met Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Ile Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  127
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: E14D-Q18R

<400>  127
atggaacacg aatggagcta cgaaggtgag aagggtcctg atcattgggc gcgtttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  128
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: E14D-Q18R

<400>  128

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Asp His Trp 
1               5                   10                  15      


Ala Arg Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  129
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Y52C-V122I-K150N-G226S

<400>  129
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtgttaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttgatcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaat atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagtcttt ctaa                                             684


<210>  130
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Y52C-V122I-K150N-G226S

<400>  130

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Cys Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Ile Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Asn Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Ser Phe 
225         


<210>  131
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G65S-K150I

<400>  131
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca attctcacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaatc atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  132
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G65S-K150I

<400>  132

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Ser His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Ile Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  133
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K57R-G130C

<400>  133
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcacg tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgtgt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  134
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K57R-G130C

<400>  134

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Arg Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Cys Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  135
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G82C-K88E

<400>  135
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact ggagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  136
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G82C-K88E

<400>  136

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Glu Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  137
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G82C-G148A

<400>  137
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga agctgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  138
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G82C-G148A

<400>  138

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Ala Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  139
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: M126L-G130L

<400>  139
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgcttgc caaactgctt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  140
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: M126L-G130L

<400>  140

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Leu Ala Lys 
        115                 120                 125             


Leu Leu Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  141
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G82C-I100V

<400>  141
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  142
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G82C-I100V

<400>  142

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  143
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38C-G82C-I100V

<400>  143
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctgtaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  144
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38C-G82C-I100V

<400>  144

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Cys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  145
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38G-G82C-I100V

<400>  145
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga cggtaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  146
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38G-G82C-I100V

<400>  146

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Gly Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  147
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38R-G82C-I100V

<400>  147
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ccgtaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  148
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38R-G82C-I100V

<400>  148

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Arg Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  149
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38S-G82C-I100V

<400>  149
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  150
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38S-G82C-I100V

<400>  150

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  151
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38W-G82C-I100V

<400>  151
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctggaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  152
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38W-G82C-I100V

<400>  152

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Trp Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  153
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38S-K57A-G82C-I100V

<400>  153
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcagc tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  154
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38S-K57A-G82C-I100V

<400>  154

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Ala Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  155
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38S-K57G-G82C-I100V

<400>  155
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga cagtaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcagg tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  156
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38S-K57G-G82C-I100V

<400>  156

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Gly Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  157
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38S-K57L-G82C-I100V

<400>  157
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  158
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38S-K57L-G82C-I100V

<400>  158

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  159
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38S-K57S-G82C-I100V

<400>  159
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcatc tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  160
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38S-K57S-G82C-I100V

<400>  160

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Ser Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  161
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K38S-K57V-G82C-I100V

<400>  161
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcagt tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  162
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K38S-K57V-G82C-I100V

<400>  162

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Val Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  163
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18F-K20G-K38S-K57L-G82C-I100V

<400>  163
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gtttttgggt       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  164
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18F-K20G-K38S-K57L-G82C-I100V

<400>  164

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Phe Leu Gly Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  165
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18R-K20G-K38S-K57L-G82C-I100V

<400>  165
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcgtttgggt       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  166
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18R-K20G-K38S-K57L-G82C-I100V

<400>  166

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Arg Leu Gly Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  167
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18W-K20G-K38S-K57L-G82C-I100V

<400>  167
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gtggttgggt       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  168
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18W-K20G-K38S-K57L-G82C-I100V

<400>  168

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Trp Leu Gly Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  169
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18R-K20W-K38S-K57L-G82C-I100V

<400>  169
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcgtttgtgg       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  170
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18R-K20W-K38S-K57L-G82C-I100V

<400>  170

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Arg Leu Trp Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  171
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18R-K20A-K38S-K57L-G82C-I100V

<400>  171
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcgtttggct       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  172
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18R-K20A-K38S-K57L-G82C-I100V

<400>  172

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Arg Leu Ala Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  173
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18R-K20R-K38S-K57L-G82C-I100V

<400>  173
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcgtttgcgt       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  174
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18R-K20R-K38S-K57L-G82C-I100V

<400>  174

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Arg Leu Arg Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  175
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18C-K20S-K38S-K57L-G82C-I100V

<400>  175
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gtgtttgtct       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  176
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18C-K20S-K38S-K57L-G82C-I100V

<400>  176

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Cys Leu Ser Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  177
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18C-K20V-K38S-K57L-G82C-I100V

<400>  177
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gtgtttggtt       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  178
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18C-K20V-K38S-K57L-G82C-I100V

<400>  178

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Cys Leu Val Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  179
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18A-K20T-K38S-K57L-G82C-I100V

<400>  179
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc ggctttgact       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  180
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18A-K20T-K38S-K57L-G82C-I100V

<400>  180

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Ala Leu Thr Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  181
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G65S

<400>  181
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca attctcacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  182
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G65S

<400>  182

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Ser His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  183
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K88E

<400>  183
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact ggagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  184
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K88E

<400>  184

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Glu Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  185
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K114I

<400>  185
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca tcaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  186
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K114I

<400>  186

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Ile Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  187
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: V122I

<400>  187
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttgatcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  188
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: V122I

<400>  188

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Ile Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  189
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: M126L

<400>  189
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgcttgc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  190
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: M126L

<400>  190

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Leu Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  191
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: G148A

<400>  191
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga agctgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  192
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: G148A

<400>  192

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Ala Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  193
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: E14D

<400>  193
atggaacacg aatggagcta cgaaggtgag aagggtcctg atcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aatctgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  194
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: E14D

<400>  194

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Asp His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  195
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18F-K20R-K38S-K57L-G82C-I100V

<400>  195
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gtttttgcgt       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga ctctaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcact tgagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgtgtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccgtt      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  196
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18F-K20R-K38S-K57L-G82C-I100V

<400>  196

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Phe Leu Arg Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Ser Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Leu Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Cys Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Val Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  197
<211>  260
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant M6X Enzyme

<400>  197

Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Thr Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser His Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Leu Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Ser Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Pro Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Thr Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  198

<400>  198
000

<210>  199
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: Q18T

<400>  199
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gactttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  200
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: Q18T

<400>  200

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Thr Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  201
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K20W

<400>  201
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgtgg       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  202
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K20W

<400>  202

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Trp Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  203
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K150I

<400>  203
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaatc atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  204
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VARIANT: K150I

<400>  204

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Ile Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  205
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: K150N

<400>  205
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaat atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

acggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  206
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: K150N

<400>  206

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Asn Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Thr Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


<210>  207
<211>  684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variant: T181M

<400>  207
atggaacacg aatggagcta cgaaggtgag aagggtcctg agcattgggc gcagttgaaa       60

ccggagttct tttggtgcaa gctgaagaat caatctccga tcaacattga caagaagtac      120

aaagtcaaag cgaatctgcc gaagctgaat ctgtattaca aaaccgcaaa agagagcgag      180

gttgtgaaca atggccacac tattcaaatc aacattaaag aggataacac cctgaattat      240

ctgggtgaaa agtatcaact gaagcagttt cattttcaca cgccgagcga gcataccatc      300

gagaagaagt cgtacccgtt ggaaatccac ttcgttcaca aaaccgagga tggtaaaatc      360

ttggtcgtgg gtgtgatggc caaactgggt aagacgaata aagagctgga caagattctg      420

aacgtggctc cggcggaaga aggtgaaaag atcctggaca aaaacctgaa cctgaacaac      480

ctgattccga aagataaacg ttatatgacg tacagcggca gcctgaccac cccaccgtgt      540

atggaaggcg ttcgttggat cgttctgaag aagccgatca gcattagcaa acagcagttg      600

gagaaactga aaagcgtcat ggtcaacccg aataatcgcc cggttcaaga aatcaattcc      660

cgttggatta ttgagggctt ctaa                                             684


<210>  208
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant: T181M

<400>  208

Met Glu His Glu Trp Ser Tyr Glu Gly Glu Lys Gly Pro Glu His Trp 
1               5                   10                  15      


Ala Gln Leu Lys Pro Glu Phe Phe Trp Cys Lys Leu Lys Asn Gln Ser 
            20                  25                  30          


Pro Ile Asn Ile Asp Lys Lys Tyr Lys Val Lys Ala Asn Leu Pro Lys 
        35                  40                  45              


Leu Asn Leu Tyr Tyr Lys Thr Ala Lys Glu Ser Glu Val Val Asn Asn 
    50                  55                  60                  


Gly His Thr Ile Gln Ile Asn Ile Lys Glu Asp Asn Thr Leu Asn Tyr 
65                  70                  75                  80  


Leu Gly Glu Lys Tyr Gln Leu Lys Gln Phe His Phe His Thr Pro Ser 
                85                  90                  95      


Glu His Thr Ile Glu Lys Lys Ser Tyr Pro Leu Glu Ile His Phe Val 
            100                 105                 110         


His Lys Thr Glu Asp Gly Lys Ile Leu Val Val Gly Val Met Ala Lys 
        115                 120                 125             


Leu Gly Lys Thr Asn Lys Glu Leu Asp Lys Ile Leu Asn Val Ala Pro 
    130                 135                 140                 


Ala Glu Glu Gly Glu Lys Ile Leu Asp Lys Asn Leu Asn Leu Asn Asn 
145                 150                 155                 160 


Leu Ile Pro Lys Asp Lys Arg Tyr Met Thr Tyr Ser Gly Ser Leu Thr 
                165                 170                 175     


Thr Pro Pro Cys Met Glu Gly Val Arg Trp Ile Val Leu Lys Lys Pro 
            180                 185                 190         


Ile Ser Ile Ser Lys Gln Gln Leu Glu Lys Leu Lys Ser Val Met Val 
        195                 200                 205             


Asn Pro Asn Asn Arg Pro Val Gln Glu Ile Asn Ser Arg Trp Ile Ile 
    210                 215                 220                 


Glu Gly Phe 
225         


