                         SEQUENCE LISTING

<110>  VAN VLASSELAER, PETER
       PARRY, GRAHAM
       STAGLIANO, NANCY E
       PANICKER, SANDIP
 
<120>  ANTI-COMPLEMENT C1S ANTIBODIES AND USES THEREOF

<130>  TNRX-800WO

<150>  US 61/779,217
<151>  2013-03-13

<150>  US 61/754,205
<151>  2013-01-18

<150>  US 61/718,519
<151>  2012-10-25

<160>  159   

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  1

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10          


<210>  2
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  2

Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro 
1               5                   10  


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  3

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  4
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  4

Gly Phe Asn Ile Lys Asp Asp Tyr Ile His Trp Val 
1               5                   10          


<210>  5
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  5

Ile Asp Pro Ala Asp Asp His Thr Lys Tyr 
1               5                   10  


<210>  6
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  6

Ala Ile Tyr Gly Ser Gly Trp Ala Trp Phe Pro Tyr 
1               5                   10          


<210>  7
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  7

Asp Ile Val Leu Thr Gln Ser Thr Asp Tyr Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  8
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  8

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asp Asp His Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Cys 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Tyr Gly Ser Gly Trp Ala Trp Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Ser Val Ser Ala 
        115                 


<210>  9
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  9

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10          


<210>  10
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  10

Asp Ala Ser Asn Leu Glu Ser Gly Ile Pro 
1               5                   10  


<210>  11
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  11

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  12
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  12

Gly Phe Asn Ile Lys Asp Asp Tyr Ile His Trp Val 
1               5                   10          


<210>  13
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  13

Ile Asp Pro Ala Asp Gly His Thr Lys Tyr 
1               5                   10  


<210>  14
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  14

Ala Arg Tyr Gly Tyr Gly Arg Glu Val Phe Asp Tyr 
1               5                   10          


<210>  15
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  15

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Thr Gly Gln Pro Pro 
        35                  40                  45              


Lys Ile Leu Ile Tyr Asp Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  16
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  16

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asp Gly His Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Val Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Tyr Gly Arg Glu Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  17
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  17

Ser Ser Ile Ser Tyr Met His Trp Tyr His Gln Lys 
1               5                   10          


<210>  18
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  18

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
1               5                   10  


<210>  19
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  19

His Gln Arg Ser Ser Phe Pro Thr 
1               5               


<210>  20
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  20

Gly Tyr Thr Phe Thr Arg Tyr Trp Met His Trp Val 
1               5                   10          


<210>  21
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  21

Ile Asn Pro Ser Asn Ser Asp Thr Asp Tyr 
1               5                   10  


<210>  22
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  22

Thr Ile Asp Asp Ser Val Tyr Gly Trp Phe Ala Tyr 
1               5                   10          


<210>  23
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  23

Asp Ile Val Ile Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr His Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Phe Pro Thr Phe 
                85                  90                  95      


Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105 


<210>  24
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  24

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Ser Asp Thr Asp Tyr Asn Glu Glu Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Asp Asp Ser Val Tyr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  25
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  25

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10          


<210>  26
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  26

Ala Ala Ser Asn Leu Glu Phe Gly Ile Pro 
1               5                   10  


<210>  27
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  27

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  28
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  28

Gly Phe Asn Ile Lys Asp Asp Tyr Ile His Trp Val 
1               5                   10          


<210>  29
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  29

Ile Asp Pro Ala Asp Asp His Thr Lys Tyr 
1               5                   10  


<210>  30
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  30

Ala Ile Tyr Gly Ser Gly Trp Ala Trp Phe Pro Tyr 
1               5                   10          


<210>  31
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  31

Asp Ile Val Met Thr Gln Ser Pro Asp Tyr Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Pro Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Phe Gly Ile Pro Thr 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Pro Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Pro Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  32
<211>  149
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  32

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asp Asp His Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Cys 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Tyr Gly Ser Gly Trp Ala Trp Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Ser Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys 
145                 


<210>  33
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  33

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10          


<210>  34
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  34

Asp Ala Ser Asn Leu Glu Phe Gly Ile Pro 
1               5                   10  


<210>  35
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  35

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  36
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  36

Gly Phe Asn Ile Lys Asp Asp Tyr Ile His Trp Val 
1               5                   10          


<210>  37
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  37

Ile Asp Pro Ala Asp Gly His Thr Lys Tyr 
1               5                   10  


<210>  38
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  38

Ala Arg Tyr Gly Tyr Gly Arg Glu Val Phe Asp Tyr 
1               5                   10          


<210>  39
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  39

Asp Ile Val Leu Thr Gln Phe Pro Thr Phe Leu Ala Val Phe Leu Gly 
1               5                   10                  15      


Gln Arg Ala Pro Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Phe Gln Gln Lys Thr Gly Gln Pro Pro 
        35                  40                  45              


Lys Ile Leu Ile Tyr Asp Ala Ser Asn Leu Glu Phe Gly Ile Pro Thr 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Pro Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Ile Tyr Phe Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Pro Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  40
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  40

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asp Gly His Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Val Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Tyr Gly Arg Glu Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  41
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  41

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10          


<210>  42
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  42

Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro 
1               5                   10  


<210>  43
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  43

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  44
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  44

Gly Phe Asn Ile Lys Asp Asp Tyr Ile His Trp Val 
1               5                   10          


<210>  45
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  45

Ile Asp Pro Ala Asp Asp His Thr Lys Tyr 
1               5                   10  


<210>  46
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  46

Ala Ile Tyr Gly Ser Gly Trp Ala Trp Phe Pro Tyr 
1               5                   10          


<210>  47
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  47

Glu Phe Ala Leu Met Thr Gln Ser Thr Asp Tyr Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr 
            20                  25                  30          


Asp Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro 
    50                  55                  60                  


Thr Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Asn Ile 
65                  70                  75                  80  


His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser 
                85                  90                  95      


Asn Glu Asp Pro Trp Thr Phe Gly Gly Gly Pro Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  48
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  48

Glu Val Lys Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asp Asp His Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Cys 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Tyr Gly Ser Gly Trp Ala Trp Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Ser Val Ser Ala 
        115                 


<210>  49
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  49

Ser Ser Ile Ser Tyr Met Tyr Trp Phe Gln Gln Lys 
1               5                   10          


<210>  50
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  50

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
1               5                   10  


<210>  51
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  51

His Gln Arg Ser Ser Asp Pro Thr 
1               5               


<210>  52
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  52

Gly Tyr Ser Phe Thr Gly Tyr Tyr Ile His Trp Val 
1               5                   10          


<210>  53
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  53

Ile Asn Pro Thr Thr Asn Asp Thr Thr Tyr 
1               5                   10  


<210>  54
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  54

Ser Arg Asp Ile Ser Gly Pro Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  55
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  55

Asp Ile Val Leu Thr Gln Thr Thr Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Asp Pro Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Asn Arg 
            100                 105     


<210>  56
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  56

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Thr Asn Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Ile Ser Gly Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  57
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  57

Ser Ser Ile Ser Tyr 
1               5   


<210>  58
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  58

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
1               5                   10  


<210>  59
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  59

His Gln Arg Ser Ser Phe Pro Pro 
1               5               


<210>  60
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  60

Gly Tyr Thr Phe Thr Arg Tyr Trp Met His Trp Val 
1               5                   10          


<210>  61
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  61

Ile Asn Pro Ser Asn Ser Asp Thr Asp Tyr 
1               5                   10  


<210>  62
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  62

Thr Ile Asp Asp Ser Val Tyr Gly Trp Phe Ala Tyr 
1               5                   10          


<210>  63
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  63

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Phe Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


Pro Trp Tyr Pro Gln Lys Pro Gly Pro Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Phe Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Pro Tyr Tyr Cys His Gln Arg Ser Ser Phe Pro Pro Phe 
                85                  90                  95      


Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105 


<210>  64
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  64

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Ser Asp Thr Asp Tyr Asn Glu Glu Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Asp Asp Ser Val Tyr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  65
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  65

Ser Ser Ile Ser Tyr Met His Trp Tyr Gln Gln Lys 
1               5                   10          


<210>  66
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  66

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
1               5                   10  


<210>  67
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  67

His Gln Arg Ser Phe Tyr Leu Thr 
1               5               


<210>  68
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  68

Gly Tyr Thr Phe Thr Asp Tyr Ala Met His Cys Val 
1               5                   10          


<210>  69
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  69

Ile Ser Ile Tyr Asn Gly Asp Ala Ser Tyr 
1               5                   10  


<210>  70
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  70

Val Arg Glu Ala Pro Tyr Leu Ile Thr Thr Val Phe Tyr Ala Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  71
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  71

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Asn Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Thr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Phe Tyr Leu Thr Phe 
                85                  90                  95      


Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  72
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  72

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Cys Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Ile Tyr Asn Gly Asp Ala Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ser Tyr 
65                  70                  75                  80  


Met Asp Leu Ala Arg Leu Thr Ser Glu Glu Ser Ala Val Tyr Asn Cys 
                85                  90                  95      


Val Arg Glu Ala Pro Tyr Leu Ile Thr Thr Val Phe Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  73
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  73

Ser Ser Ile Ser Tyr Met His Trp Tyr His Gln Lys 
1               5                   10          


<210>  74
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  74

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
1               5                   10  


<210>  75
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  75

His Gln Arg Ser Ser Phe Pro Thr 
1               5               


<210>  76
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  76

Gly Tyr Thr Phe Thr Arg Tyr Trp Met His Trp Val 
1               5                   10          


<210>  77
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  77

Ile Asn Pro Ser Asn Ser Asp Thr Asp Tyr 
1               5                   10  


<210>  78
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  78

Thr Ile Asp Asp Ser Ala Tyr Gly Trp Phe Ala Tyr 
1               5                   10          


<210>  79
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  79

Asp Ile Val Leu Thr Gln Ser Thr Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr His Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Ala Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Phe Pro Thr Phe 
                85                  90                  95      


Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105 


<210>  80
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  80

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Ser Asp Thr Asp Tyr Asn Glu Glu Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Asn Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Asp Asp Ser Ala Tyr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  81
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  81

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10          


<210>  82
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  82

Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro 
1               5                   10  


<210>  83
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  83

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  84
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  84

Gly Phe Asn Ile Lys Asp Asp Tyr Ile His Trp Val 
1               5                   10          


<210>  85
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  85

Ile Asp Pro Ala Asp Asp His Thr Lys Tyr 
1               5                   10  


<210>  86
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  86

Ala Ile Tyr Gly Ser Gly Trp Ala Trp Phe Pro Tyr 
1               5                   10          


<210>  87
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  87

Asp Ile Val Leu Thr Gln Thr Pro Asp Tyr Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  88
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  88

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asp Asp His Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Cys 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Tyr Gly Ser Gly Trp Ala Trp Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Ser Val Ser Ala 
        115                 


<210>  89
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  89

Ser Ser Ile Ser Tyr Ile His Trp Tyr Gln Gln Lys 
1               5                   10          


<210>  90
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  90

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
1               5                   10  


<210>  91
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  91

His Gln Arg Ser Ser Tyr Leu Thr 
1               5               


<210>  92
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  92

Gly Tyr Ser Phe Thr Gly Phe Tyr Met Gln Trp Val 
1               5                   10          


<210>  93
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  93

Ile Asn Pro Thr Thr Gly Asp Glu Thr Tyr 
1               5                   10  


<210>  94
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  94

Ala Ser Asp Phe Tyr Asp Gly Ser Phe Ala Trp Phe Glu Tyr 
1               5                   10                  


<210>  95
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  95

Asp Ile Val Leu Thr Gln Ser Pro Val Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Leu Thr Phe 
                85                  90                  95      


Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  96
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  96

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Phe 
            20                  25                  30          


Tyr Met Gln Trp Val Lys Gln Ser Pro Glu Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Thr Gly Asp Glu Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Asp Phe Tyr Asp Gly Ser Phe Ala Trp Phe Glu Tyr Trp Gly 
            100                 105                 110         


Lys Asp Tyr Leu Thr Val Ser Ala 
        115                 120 


<210>  97
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  97

Ser Ser Ile Asn Tyr Met His Trp Tyr Gln Gln Lys 
1               5                   10          


<210>  98
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  98

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
1               5                   10  


<210>  99
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  99

His Gln Arg Ser Asp Ser Leu Thr 
1               5               


<210>  100
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  100

Gly Tyr Ser Phe Thr Gly Tyr Tyr Met His Trp Val 
1               5                   10          


<210>  101
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  101

Ile Asn Pro Ser Ile Gly Asp Ile Thr Tyr 
1               5                   10  


<210>  102
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  102

Ala Ser Asp Tyr Tyr Gly Gly Gly Phe Ala Trp Phe Ala Tyr 
1               5                   10                  


<210>  103
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  103

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Ser Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Thr Tyr Tyr Cys His Gln Arg Ser Asp Ser Leu Thr Phe 
                85                  90                  95      


Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  104
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  104

Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Ile Gly Asp Ile Thr Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asp Tyr Tyr Gly Gly Gly Phe Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  105
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  105

Ser Ser Ile Ser Tyr Met His Trp Tyr His Gln Lys 
1               5                   10          


<210>  106
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  106

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
1               5                   10  


<210>  107
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  107

His Gln Arg Ser Ser Phe Pro Thr 
1               5               


<210>  108
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  108

Gly Tyr Thr Phe Thr Arg Tyr Trp Met His Trp Val 
1               5                   10          


<210>  109
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  109

Ile Asn Pro Ser Asn Ser Asp Thr Asp Tyr 
1               5                   10  


<210>  110
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  110

Thr Ile Asp Asp Ser Ala Tyr Gly Trp Phe Ala Tyr 
1               5                   10          


<210>  111
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  111

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr His Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Phe Pro Thr Phe 
                85                  90                  95      


Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105 


<210>  112
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  112

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Ser Asp Thr Asp Tyr Asn Glu Glu Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Asp Asp Ser Ala Tyr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  113
<211>  673
<212>  PRT
<213>  Homo Sapiens

<400>  113

Glu Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala 
1               5                   10                  15      


Tyr Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly 
            20                  25                  30          


Tyr Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu 
        35                  40                  45              


Asn Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu 
    50                  55                  60                  


Gly Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile 
65                  70                  75                  80  


Val Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys 
                85                  90                  95      


Ser Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr 
            100                 105                 110         


Val Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys 
        115                 120                 125             


Ser His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro 
    130                 135                 140                 


Pro Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys 
145                 150                 155                 160 


Ser Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn 
                165                 170                 175     


Tyr Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu Tyr Gln Ile Arg 
            180                 185                 190         


Leu Glu Lys Gly Phe Gln Val Val Val Thr Leu Arg Arg Glu Asp Phe 
        195                 200                 205             


Asp Val Glu Ala Ala Asp Ser Ala Gly Asn Cys Leu Asp Ser Leu Val 
    210                 215                 220                 


Phe Val Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe 
225                 230                 235                 240 


Pro Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile 
                245                 250                 255     


Phe Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr 
            260                 265                 270         


His Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val 
        275                 280                 285             


Trp Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val Gln Ile 
    290                 295                 300                 


Thr Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val Gly Ala Thr 
305                 310                 315                 320 


Ser Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser Asn Ser Lys 
                325                 330                 335     


Leu Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser Ile Glu Asn 
            340                 345                 350         


Gly Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg 
        355                 360                 365             


Tyr Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly 
    370                 375                 380                 


Glu Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly 
385                 390                 395                 400 


Pro Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu Pro 
                405                 410                 415     


Phe Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala Asp Ile Lys 
            420                 425                 430         


Asn Phe Pro Trp Gln Val Phe Phe Asp Asn Pro Trp Ala Gly Gly Ala 
        435                 440                 445             


Leu Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu Gly 
    450                 455                 460                 


Asn Arg Glu Pro Thr Met Tyr Val Gly Ser Thr Ser Val Gln Thr Ser 
465                 470                 475                 480 


Arg Leu Ala Lys Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His 
                485                 490                 495     


Pro Gly Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp 
            500                 505                 510         


Asn Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro 
        515                 520                 525             


Thr Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn Leu 
    530                 535                 540                 


Met Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly Arg Thr Glu Lys 
545                 550                 555                 560 


Arg Asp Arg Ala Val Arg Leu Lys Ala Ala Arg Leu Pro Val Ala Pro 
                565                 570                 575     


Leu Arg Lys Cys Lys Glu Val Lys Val Glu Lys Pro Thr Ala Asp Ala 
            580                 585                 590         


Glu Ala Tyr Val Phe Thr Pro Asn Met Ile Cys Ala Gly Gly Glu Lys 
        595                 600                 605             


Gly Met Asp Ser Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln 
    610                 615                 620                 


Asp Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp 
625                 630                 635                 640 


Gly Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr 
                645                 650                 655     


Val Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu 
            660                 665                 670         


Asp 
    


<210>  114
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  114

Gly Ser Gly Gly Ser 
1               5   


<210>  115
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  115

Gly Gly Gly Ser 
1               


<210>  116
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  116

Gly Gly Ser Gly 
1               


<210>  117
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  117

Gly Gly Ser Gly Gly 
1               5   


<210>  118
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  118

Gly Ser Gly Ser Gly 
1               5   


<210>  119
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  119

Gly Ser Gly Gly Gly 
1               5   


<210>  120
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  120

Gly Gly Gly Ser Gly 
1               5   


<210>  121
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  121

Gly Ser Ser Ser Gly 
1               5   


<210>  122
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  122

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  123
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  123

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  124
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  124

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  125
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  125

His His His His His 
1               5   


<210>  126
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  126

His His His His His His 
1               5       


<210>  127
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  127

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  128
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  128

Arg Tyr Ile Arg Ser 
1               5   


<210>  129
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  129

Phe His His Thr 
1               


<210>  130
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  130

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  131
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  131

Thr Phe Phe Tyr Gly Gly Cys Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr 
            


<210>  132
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  132

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr 
            


<210>  133
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  133

Cys Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys 
1               5                   10                  15      


Thr Glu Glu Tyr 
            20  


<210>  134
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  134

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr Cys 
            20  


<210>  135
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  135

Thr Phe Val Tyr Gly Gly Cys Arg Ala Lys Arg Asn Asn Phe Lys Ser 
1               5                   10                  15      


<210>  136
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  137
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  137

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10              


<210>  138
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  138

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  139
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  139

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  140
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  140

Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  141
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  141

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  142
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  142

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
1               5                   10              


<210>  143
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  143

Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  144
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  144

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  145
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  145

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10              


<210>  146
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  146

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  147
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  147

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  148
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  148

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  149
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  149

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  150
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  150

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  151
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  151

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  152
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  152

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  153
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  153

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  154
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  154

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  155
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  155

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  156
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  156

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  157
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  157

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  158
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  158

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  159
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  159

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


