                         SEQUENCE LISTING

<110>  Imhof, Beat A.
       Ody, Christiane
       Matthes, Thomas
       Donate, Carmen
 
<120>  JAM-C ANTIBODIES AND METHODS FOR TREATMENT OF CANCER

<130>  CLFR.P0402WO

<140>  unknown
<141>  2013-10-24

<150>  US 61/717,796
<151>  2012-10-24

<150>  US 61/773,933
<151>  2013-03-07

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  747
<212>  DNA
<213>  Homo sapien


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  1
atggcgctga ggcgnccacc gcgactccgg ctctgcgctc ggctgcctga cttcttcctg       60

ctgctgcttt tcaggggctg cctgataggg gctgtaaatc tcaaatccag caatcgaacc      120

ccagtggtac aggaatttga aagtgtggaa ctgtcttgca tcattacgga ttcgcagaca      180

agtgacccca ggatcgagtg gaagaaaatt caagatgaac aaaccacata tgtgtttttt      240

gacaacaaaa ttcagggaga cttggcgggt cgtgcagaaa tactggggaa gacatccctg      300

aagatctgga atgtgacacg gagagactca gccctttatc gctgtgaggt cgttgctcga      360

aatgaccgca aggaaattga tgagattgtg atcgagttaa ctgtgcaagt gaagccagtg      420

acccctgtct gtagagtgcc gaaggctgta ccagtaggca agatggcaac actgcactgc      480

caggagagtg agggccaccc ccggcctcac tacagctggt atcgcaatga tgtaccactg      540

cccacggatt ccagagccaa tcccagattt cgcaattctt ctttccactt aaactctgaa      600

acaggcactt tggtgttcac tgctgttcac aaggacgact ctgggcagta ctactgcatt      660

gcttccaatg acgcaggctc agccaggtgt gaggagcagg agatggaagt ctctagaggg      720

cccgactaca aggacgacga tgacaag                                          747


<210>  2
<211>  249
<212>  PRT
<213>  Homo sapien

<400>  2

Met Ala Leu Arg Arg Pro Pro Arg Leu Arg Leu Cys Ala Arg Leu Pro 
1               5                   10                  15      


Asp Phe Phe Leu Leu Leu Leu Phe Arg Gly Cys Leu Ile Gly Ala Val 
            20                  25                  30          


Asn Leu Lys Ser Ser Asn Arg Thr Pro Val Val Gln Glu Phe Glu Ser 
        35                  40                  45              


Val Glu Leu Ser Cys Ile Ile Thr Asp Ser Gln Thr Ser Asp Pro Arg 
    50                  55                  60                  


Ile Glu Trp Lys Lys Ile Gln Asp Glu Gln Thr Thr Tyr Val Phe Phe 
65                  70                  75                  80  


Asp Asn Lys Ile Gln Gly Asp Leu Ala Gly Arg Ala Glu Ile Leu Gly 
                85                  90                  95      


Lys Thr Ser Leu Lys Ile Trp Asn Val Thr Arg Arg Asp Ser Ala Leu 
            100                 105                 110         


Tyr Arg Cys Glu Val Val Ala Arg Asn Asp Arg Lys Glu Ile Asp Glu 
        115                 120                 125             


Ile Val Ile Glu Leu Thr Val Gln Val Lys Pro Val Thr Pro Val Cys 
    130                 135                 140                 


Arg Val Pro Lys Ala Val Pro Val Gly Lys Met Ala Thr Leu His Cys 
145                 150                 155                 160 


Gln Glu Ser Glu Gly His Pro Arg Pro His Tyr Ser Trp Tyr Arg Asn 
                165                 170                 175     


Asp Val Pro Leu Pro Thr Asp Ser Arg Ala Asn Pro Arg Phe Arg Asn 
            180                 185                 190         


Ser Ser Phe His Leu Asn Ser Glu Thr Gly Thr Leu Val Phe Thr Ala 
        195                 200                 205             


Val His Lys Asp Asp Ser Gly Gln Tyr Tyr Cys Ile Ala Ser Asn Asp 
    210                 215                 220                 


Ala Gly Ser Ala Arg Cys Glu Glu Gln Glu Met Glu Val Ser Arg Gly 
225                 230                 235                 240 


Pro Asp Tyr Lys Asp Asp Asp Asp Lys 
                245                 


<210>  3
<211>  238
<212>  PRT
<213>  Homo sapien

<400>  3

Met Ala Arg Arg Ser Arg His Arg Leu Leu Leu Leu Leu Leu Arg Tyr 
1               5                   10                  15      


Leu Val Val Ala Leu Gly Tyr His Lys Ala Tyr Gly Phe Ser Ala Pro 
            20                  25                  30          


Lys Asp Gln Gln Val Val Thr Ala Val Glu Tyr Gln Glu Ala Ile Leu 
        35                  40                  45              


Ala Cys Lys Thr Pro Lys Lys Thr Val Ser Ser Arg Leu Glu Trp Lys 
    50                  55                  60                  


Lys Leu Gly Arg Ser Val Ser Phe Val Tyr Tyr Gln Gln Thr Leu Gln 
65                  70                  75                  80  


Gly Asp Phe Lys Asn Arg Ala Glu Met Ile Asp Phe Asn Ile Arg Ile 
                85                  90                  95      


Lys Asn Val Thr Arg Ser Asp Ala Gly Lys Tyr Arg Cys Glu Val Ser 
            100                 105                 110         


Ala Pro Ser Glu Gln Gly Gln Asn Leu Glu Glu Asp Thr Val Thr Leu 
        115                 120                 125             


Glu Val Leu Val Ala Pro Ala Val Pro Ser Cys Glu Val Pro Ser Ser 
    130                 135                 140                 


Ala Leu Ser Gly Thr Val Val Glu Leu Arg Cys Gln Asp Lys Glu Gly 
145                 150                 155                 160 


Asn Pro Ala Pro Glu Tyr Thr Trp Phe Lys Asp Gly Ile Arg Leu Leu 
                165                 170                 175     


Glu Asn Pro Arg Leu Gly Ser Gln Ser Thr Asn Ser Ser Tyr Thr Met 
            180                 185                 190         


Asn Thr Lys Thr Gly Thr Leu Gln Phe Asn Thr Val Ser Lys Leu Asp 
        195                 200                 205             


Thr Gly Glu Tyr Ser Cys Glu Ala Arg Asn Ser Val Gly Tyr Arg Arg 
    210                 215                 220                 


Cys Pro Gly Lys Arg Met Gln Val Asp Asp Leu Asn Ile Ser 
225                 230                 235             


<210>  4
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 
            20                  25                  30          


Tyr Ile Asn Trp Leu Lys Gln Thr Thr Gly Gln Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Asn Thr Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Ser Gly Tyr Val Leu Asp Tyr Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  5
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn Ile Asn Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Glu Lys Val Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asn Val Ala Thr Tyr Phe Cys Leu Gln Tyr Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Met His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Gly Asn Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Met Gln Leu Gly Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Val Asp Tyr Trp Gly Gln Gly Val Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  7
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Phe Gln Tyr Asn Ser Gly Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105     


<210>  8
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile Ser Trp Ile Lys Gln Thr Thr Gly Gln Gly Leu Asp Phe Ile 
        35                  40                  45              


Gly Tyr Ile Asn Thr Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Asp Thr Thr Pro Phe Asp Tyr Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn Ile Asn Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Glu Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Leu Gln Tyr Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile Ser Trp Ile Lys Gln Thr Thr Gly Gln Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Ser Thr Gly Ser Gly Ser Ala Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Arg Pro Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Thr Ile Ala Val Leu Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  11
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Asp Ile Val Leu Thr Gln Ser Pro Ala Leu Ala Val Ser Pro Gly Glu 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Thr Leu Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Leu Ala Ser His Leu Glu Ser Gly Val Pro Ala Lys Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp 
65                  70                  75                  80  


Asp Thr Ala Thr Tyr Tyr Cys His Gln Ser Trp Asn Asp Pro Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Gly Tyr Thr Phe Thr Ser Phe Tyr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Ile Asn Thr Gly Ser Gly Gly Thr 
1               5               


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Ala Arg Asp Asn Ser Gly Tyr Val Leu Asp Tyr 
1               5                   10      


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Gln Asn Ile Asn Arg Tyr 
1               5       


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Asn Ala Asn 
1           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Leu Gln Tyr Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  18

Gly Tyr Thr Phe Thr Ser Tyr Asp 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Ile Tyr Pro Gly Asn Gly Asn Thr 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Ala Arg Gly Asp Gly Val Asp Tyr 
1               5               


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  21

Gln Asn Ile Asn Lys Tyr 
1               5       


<210>  22
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  22

Lys Thr Asn 
1           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  23

Phe Gln Tyr Asn Ser Gly Pro Arg Thr 
1               5                   


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  24

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  25

Ala Arg Asp Glu Asp Thr Thr Pro Phe Asp Tyr 
1               5                   10      


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Ile Ser Thr Gly Ser Gly Ser Ala 
1               5               


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  27

Ala Arg Arg Asp Thr Ile Ala Val Leu Ala Tyr 
1               5                   10      


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Cys Arg Ala Ser Glu Ser Val Ser Thr Leu 
1               5                   10  


<210>  29
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  29

Leu Ala Ser 
1           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  30

His Gln Ser Trp Asn Asp Pro Tyr Thr 
1               5                   


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Phe, Tyr or Trp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Tyr or Asp

<400>  31

Gly Tyr Thr Phe Thr Ser Xaa Xaa 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Asn or Tyr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X isThr or Pro

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Gly or Asn

<400>  32

Ile Xaa Xaa Gly Xaa Gly Xaa Thr 
1               5               


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is Arg, His or Lys

<400>  33

Gln Asn Ile Asn Xaa Tyr 
1               5       


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Phe or Leu

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X9 is Gly or Trp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X10 is Arg or Leu

<400>  34

Xaa Gln Tyr Asn Ser Xaa Pro Xaa Thr 
1               5                   


