                         SEQUENCE LISTING

<110>  University of Rochester
       Wedekind, Joseph E.
       Salter, Jason D.
       Lippa, Geoffrey M.
       Belashov, Ivan A.
 
<120>  Assay for Screening of Anti-Viral Compounds that Inhibit Specific
        Interaction Interfaces between Cullin5 and an 
       ElonginB/ElonginC/CBF-beta/HIV-1 Vif Complex

<130>  204606-0016-00-WO.602793

<150>  US 61/716,916
<151>  2012-10-22

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  1

Arg Thr Trp Lys Ser Leu Val Lys His His Met Tyr Val Ser Gly Lys 
1               5                   10                  15      


Ala Arg Gly Trp Phe 
            20      


<210>  2
<211>  14
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  2

Trp Arg Lys Lys Arg Tyr Ser Thr Gln Val Asp Pro Glu Leu 
1               5                   10                  


<210>  3
<211>  2
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  3

Phe Asp 
1       


<210>  4
<211>  2
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  4

Cys Phe 
1       


<210>  5
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  5

Asp Ser Ala Ile Arg Lys Ala Leu Leu 
1               5                   


<210>  6
<211>  8
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  6

Ile Val Ser Pro Arg Cys Glu Tyr 
1               5               


<210>  7
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  7

Gln Ala Gly His Asn Lys Val Gly Ser Leu Gln 
1               5                   10      


<210>  8
<211>  17
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  8

Leu Ile Thr Pro Lys Lys Ile Lys Pro Pro Leu Pro Ser Pro Thr Lys 
1               5                   10                  15      


Leu 
    


<210>  9
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Arg Gln Glu Ser Val Thr Lys Gln Gln Trp 
1               5                   10      


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu Phe Ser Asp Val His Ala Val Cys Leu 
1               5                   10  


<210>  11
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Lys Gly Pro Ala Lys Ile His Gln Ala Leu 
1               5                   10      


<210>  12
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  12

Leu Arg Gln Glu Ser Val Thr Lys Gln Gln Trp Phe Asp Leu Phe Ser 
1               5                   10                  15      


Asp Val His Ala Val Cys Leu Trp Asp Asp Lys Gly Pro Ala Lys Ile 
            20                  25                  30          


His Gln Ala Leu 
        35      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  13

Leu Arg Gln Glu Ser Val Thr Lys Gln Gln Trp 
1               5                   10      


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  14

Leu Phe Ser Asp Val His Ala Val Cys Leu Trp Asp 
1               5                   10          


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  15

Asp Lys Gly Pro Ala Lys Ile His Gln Ala Leu 
1               5                   10      


<210>  16
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  16

Leu Phe Ser Asp Val His Ala Val Cys Leu Trp Asp Asp Lys Gly Pro 
1               5                   10                  15      


Ala Lys Ile His Gln Ala Leu 
            20              


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  17

Lys Gln Gln Trp Phe Asp Leu Phe Ser Asp Val His Ala Val Cys Leu 
1               5                   10                  15      


Trp 
    


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  18

Lys Gln Gln Trp Phe Asp Leu Phe Ser Asp Val His 
1               5                   10          


<210>  19
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  19

Glu Asn Leu Tyr Phe Gln Ser Ala Ser Gly Gly His His His His Gly 
1               5                   10                  15      


His His His His Thr Ser Gly Gly Glu Asn Leu Tyr Phe Gln Ser Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  20

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  21

His His His His Gly His His His His 
1               5                   


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  22

Met Gly His His His His His His Leu Glu Val Leu Phe Gln Gly Pro 
1               5                   10                  15      


<210>  23
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Asp Val Phe Leu Met Ile Arg Arg His Lys Thr Thr Ile Phe 
1               5                   10                  15      


Thr Asp Ala Lys Glu Ser Ser Thr Val Phe Glu Leu Lys Arg Ile Val 
            20                  25                  30          


Glu Gly Ile Leu Lys Arg Pro Pro Asp Glu Gln Arg Leu Tyr Lys Asp 
        35                  40                  45              


Asp Gln Leu Leu Asp Asp Gly Lys Thr Leu Gly Glu Cys Gly Phe Thr 
    50                  55                  60                  


Ser Gln Thr Ala Arg Pro Gln Ala Pro Ala Thr Val Gly Leu Ala Phe 
65                  70                  75                  80  


Arg Ala Asp Asp Thr Phe Glu Ala Leu Cys Ile Glu Pro Phe Ser Ser 
                85                  90                  95      


Pro Pro Glu Leu Pro Asp Val Met Lys Pro Gln Asp Ser Gly Ser Ser 
            100                 105                 110         


Ala Asn Glu Gln Ala Val Gln 
        115                 


<210>  24
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Tyr Val Lys Leu Ile Ser Ser Asp Gly His Glu Phe Ile Val 
1               5                   10                  15      


Lys Arg Glu His Ala Leu Thr Ser Gly Thr Ile Lys Ala Met Leu Ser 
            20                  25                  30          


Gly Pro Gly Gln Phe Ala Glu Asn Glu Thr Asn Glu Val Asn Phe Arg 
        35                  40                  45              


Glu Ile Pro Ser His Val Leu Ser Lys Val Cys Met Tyr Phe Thr Tyr 
    50                  55                  60                  


Lys Val Arg Tyr Thr Asn Ser Ser Thr Glu Ile Pro Glu Phe Pro Ile 
65                  70                  75                  80  


Ala Pro Glu Ile Ala Leu Glu Leu Leu Met Ala Ala Asn Phe Leu Asp 
                85                  90                  95      


Cys 
    


<210>  25
<211>  102
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  25

Ser Gly Gly Gly Ser Thr Gln Val Asp Pro Glu Leu Ala Asp Gln Leu 
1               5                   10                  15      


Ile His Leu Tyr Tyr Phe Asp Cys Phe Ser Asp Ser Ala Ile Arg Lys 
            20                  25                  30          


Ala Leu Leu Gly His Ile Val Ser Pro Arg Cys Glu Tyr Gln Ala Gly 
        35                  40                  45              


His Asn Lys Val Gly Ser Leu Gln Tyr Leu Ala Leu Ala Ala Leu Ile 
    50                  55                  60                  


Thr Pro Lys Lys Ile Lys Pro Pro Leu Pro Ser Val Thr Lys Leu Thr 
65                  70                  75                  80  


Glu Asp Arg Trp Asn Lys Pro Gln Lys Thr Lys Gly His Arg Gly Ser 
                85                  90                  95      


His Thr Met Asn Gly His 
            100         


<210>  26
<211>  193
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  26

Met Gly Glu Asn Arg Trp Gln Val Met Ile Val Trp Gln Val Asp Arg 
1               5                   10                  15      


Met Arg Ile Arg Thr Trp Lys Ser Leu Val Lys His His Met Tyr Val 
            20                  25                  30          


Ser Gly Lys Ala Arg Gly Trp Phe Tyr Arg His His Tyr Glu Ser Pro 
        35                  40                  45              


His Pro Arg Ile Ser Ser Glu Val His Ile Pro Leu Gly Asp Ala Arg 
    50                  55                  60                  


Leu Val Ile Thr Thr Tyr Trp Gly Leu His Thr Gly Glu Arg Asp Trp 
65                  70                  75                  80  


His Leu Gly Gln Gly Val Ser Ile Glu Trp Arg Lys Lys Arg Tyr Ser 
                85                  90                  95      


Thr Gln Val Asp Pro Glu Leu Ala Asp Gln Leu Ile His Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Cys Phe Ser Asp Ser Ala Ile Arg Lys Ala Leu Leu Gly His 
        115                 120                 125             


Ile Val Ser Pro Arg Cys Glu Tyr Gln Ala Gly His Asn Lys Val Gly 
    130                 135                 140                 


Ser Leu Gln Tyr Leu Ala Leu Ala Ala Leu Ile Thr Pro Lys Lys Ile 
145                 150                 155                 160 


Lys Pro Pro Leu Pro Ser Val Thr Lys Leu Thr Glu Asp Arg Trp Asn 
                165                 170                 175     


Lys Pro Gln Lys Thr Lys Gly His Arg Gly Ser His Thr Met Asn Gly 
            180                 185                 190         


His 
    


<210>  27
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly His His His His His His Leu Glu Val Leu Phe Gln Gly Pro 
1               5                   10                  15      


Pro Arg Val Val Pro Asp Gln Arg Ser Lys Phe Glu Asn Glu Glu Phe 
            20                  25                  30          


Phe Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Thr Gly Phe Arg 
        35                  40                  45              


Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys Arg 
    50                  55                  60                  


Asp Gly Arg Ser Glu Ile Ala Phe Val Ala Thr Gly Thr Asn Leu Ser 
65                  70                  75                  80  


Leu Gln Phe Phe Pro Ala Ser Trp Gln Gly Glu Gln Arg Gln Thr Pro 
                85                  90                  95      


Ser Arg Glu Tyr Val Asp Leu Glu Arg Glu Ala Gly Lys Val Tyr Leu 
            100                 105                 110         


Lys Ala Pro Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly Trp 
        115                 120                 125             


Ile Asp Leu Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp Glu 
    130                 135                 140                 


Glu Arg Ala Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu Glu 
145                 150                 155                 160 


Ala Arg Arg Arg Thr Arg Glu Phe Glu Asp Arg Asp Arg Ser His Arg 
                165                 170                 175     


Glu Glu Met Glu Val Arg Val Ser Gln Leu Leu Ala Val Thr Gly Lys 
            180                 185                 190         


Lys Thr Thr Arg Pro 
        195         


<210>  28
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  28

Met Gly Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln 
1               5                   10                  15      


Pro Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His 
            20                  25                  30          


Leu Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu 
        35                  40                  45              


Leu Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val 
    50                  55                  60                  


Lys Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His 
65                  70                  75                  80  


Asn Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu 
                85                  90                  95      


Glu Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr 
            100                 105                 110         


Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro 
        115                 120                 125             


Glu Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu 
    130                 135                 140                 


Asn Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu 
145                 150                 155                 160 


Asp Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys 
                165                 170                 175     


Leu Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys 
            180                 185                 190         


Tyr Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln 
        195                 200                 205             


Ala Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val 
    210                 215                 220                 


Leu Phe Gln Gly Pro Met His Met Gly Gly Ser Thr Ser Asn Leu Leu 
225                 230                 235                 240 


Lys Asn Lys Gly Ser Leu Gln Phe Glu Asp Lys Trp Asp Phe Met Arg 
                245                 250                 255     


Pro Ile Val Leu Lys Leu Leu Arg Gln Glu Ser Val Thr Lys Gln Gln 
            260                 265                 270         


Trp Phe Asp Leu Phe Ser Asp Val His Ala Val Cys Leu Trp Asp Asp 
        275                 280                 285             


Lys Gly Pro Ala Lys Ile His Gln Ala Leu Lys Glu Asp Ile Leu Glu 
    290                 295                 300                 


Phe Ile Lys Gln Ala Gln Ala Arg Val Leu Ser His Gln Asp Asp Thr 
305                 310                 315                 320 


Ala Leu Leu Lys Ala Tyr Ile Val Glu Trp Arg Lys Phe Phe Thr Gln 
                325                 330                 335     


Cys Asp Ile Leu Pro Lys Pro Phe Cys Gln Leu Glu Ile Thr Leu Met 
            340                 345                 350         


Gly Lys Gln Gly Ser Asn Lys Lys Ser Asn Val Glu Asp Ser Ile Val 
        355                 360                 365             


Arg Lys Leu Met Leu Asp Thr Trp Asn Glu Ser Ile Phe Ser Asn Ile 
    370                 375                 380                 


Lys Asn Arg Leu Gln Asp Ser Ala Met Lys Leu Val His Ala Glu Arg 
385                 390                 395                 400 


Leu Gly Glu Ala Phe Asp Ser Gln Leu Val Ile Gly Val Arg Glu Ser 
                405                 410                 415     


Tyr Val Asn Leu Cys Ser Asn Pro Glu Asp Lys Leu Gln Ile Tyr Arg 
            420                 425                 430         


Asp Asn Phe Glu Lys Ala Tyr Leu Asp Ser Thr Glu Arg Phe Tyr Arg 
        435                 440                 445             


Thr Gln Ala Pro Ser Tyr Leu Gln Gln Asn Gly Val Gln Asn Tyr Met 
    450                 455                 460                 


Lys Tyr Ala Asp Ala Lys Leu Lys Glu Glu Glu Lys Arg Ala Leu Arg 
465                 470                 475                 480 


Tyr Leu Glu Thr Arg Arg Glu Cys Asn Ser Val Glu Ala Leu Met Glu 
                485                 490                 495     


Cys Cys Val Asn Ala Leu Val Thr Ser Phe Lys Glu Thr Ile Leu Ala 
            500                 505                 510         


Glu Cys Gln Gly Met Ile Lys Arg Asn Glu Thr Glu Lys Leu His Leu 
        515                 520                 525             


Met Phe Ser Leu Met Asp Lys Val Pro Asn Gly Ile Glu Pro Met Leu 
    530                 535                 540                 


Lys Asp Leu Glu Glu His Ile Ile Ser Ala Gly Leu Ala Asp Met Val 
545                 550                 555                 560 


Ala Ala Ala Glu Thr Ile Thr Thr Asp Ser Glu Lys Tyr Arg Glu Gln 
                565                 570                 575     


Leu Asp Thr Leu Phe Asn Arg Phe Ser Lys Leu Val Lys Glu Ala Phe 
            580                 585                 590         


Gln Asp Asp Pro Arg Phe Leu Thr Ala Arg Asp Lys Ala Tyr Lys Ala 
        595                 600                 605             


Val Val Asn Asp Ala Thr Ile Phe Lys 
    610                 615         


<210>  29
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Pro Met His Met Gly Gly Ser Thr Ser Asn Leu Leu Lys Asn Lys 
1               5                   10                  15      


Gly Ser Leu Gln Phe Glu Asp Lys Trp Asp Phe Met Arg Pro Ile Val 
            20                  25                  30          


Leu Lys Leu Leu Arg Gln Glu Ser Val Thr Lys Gln Gln Trp Phe Asp 
        35                  40                  45              


Leu Phe Ser Asp Val His Ala Val Cys Leu Trp Asp Asp Lys Gly Pro 
    50                  55                  60                  


Ala Lys Ile His Gln Ala Leu Lys Glu Asp Ile Leu Glu Phe Ile Lys 
65                  70                  75                  80  


Gln Ala Gln Ala Arg Val Leu Ser His Gln Asp Asp Thr Ala Leu Leu 
                85                  90                  95      


Lys Ala Tyr Ile Val Glu Trp Arg Lys Phe Phe Thr Gln Cys Asp Ile 
            100                 105                 110         


Leu Pro Lys Pro Phe Cys Gln Leu Glu Ile Thr Leu Met Gly Lys Gln 
        115                 120                 125             


Gly Ser Asn Lys Lys Ser Asn Val Glu Asp Ser Ile Val Arg Lys Leu 
    130                 135                 140                 


Met Leu Asp Thr Trp Asn Glu Ser Ile Phe Ser Asn Ile Lys Asn Arg 
145                 150                 155                 160 


Leu Gln Asp Ser Ala Met Lys Leu Val His Ala Glu Arg Leu Gly Glu 
                165                 170                 175     


Ala Phe Asp Ser Gln Leu Val Ile Gly Val Arg Glu Ser Tyr Val Asn 
            180                 185                 190         


Leu Cys Ser Asn Pro Glu Asp Lys Leu Gln Ile Tyr Arg Asp Asn Phe 
        195                 200                 205             


Glu Lys Ala Tyr Leu Asp Ser Thr Glu Arg Phe Tyr Arg Thr Gln Ala 
    210                 215                 220                 


Pro Ser Tyr Leu Gln Gln Asn Gly Val Gln Asn Tyr Met Lys Tyr Ala 
225                 230                 235                 240 


Asp Ala Lys Leu Lys Glu Glu Glu Lys Arg Ala Leu Arg Tyr Leu Glu 
                245                 250                 255     


Thr Arg Arg Glu Cys Asn Ser Val Glu Ala Leu Met Glu Cys Cys Val 
            260                 265                 270         


Asn Ala Leu Val Thr Ser Phe Lys Glu Thr Ile Leu Ala Glu Cys Gln 
        275                 280                 285             


Gly Met Ile Lys Arg Asn Glu Thr Glu Lys Leu His Leu Met Phe Ser 
    290                 295                 300                 


Leu Met Asp Lys Val Pro Asn Gly Ile Glu Pro Met Leu Lys Asp Leu 
305                 310                 315                 320 


Glu Glu His Ile Ile Ser Ala Gly Leu Ala Asp Met Val Ala Ala Ala 
                325                 330                 335     


Glu Thr Ile Thr Thr Asp Ser Glu Lys Tyr Arg Glu Gln Leu Asp Thr 
            340                 345                 350         


Leu Phe Asn Arg Phe Ser Lys Leu Val Lys Glu Ala Phe Gln Asp Asp 
        355                 360                 365             


Pro Arg Phe Leu Thr Ala Arg Asp Lys Ala Tyr Lys Ala Val Val Asn 
    370                 375                 380                 


Asp Ala Thr Ile Phe Lys 
385                 390 


<210>  30
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  30
atgggcgatg tgttcctgat gatccgccgt cacaagacca cgatttttac cgacgctaaa       60

gaatcttcta ccgttttcga actgaaacgc atcgtcgaag gtattctgaa acgcccgccg      120

gacgaacagc gtctgtataa agatgatcag ctgctggatg acggcaaaac cctgggcgag      180

tgtggtttca cttctcagac ggcacgtccg caggcccctg caaccgttgg tctggcgttt      240

cgtgccgacg atacctttga agctctgtgc attgaaccgt tctccagccc gccagagctc      300

cccgatgtga tgaagccgca ggactctggt tcttctgcga acgaacaggc ggttcagtct      360

agaggtaagc ctattcctaa ccctctcctc ggtctcgatt ctacggatat cgtgagcaag      420

ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac      480

ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc      540

ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc      600

ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc      660

ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac      720

ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc      780

gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac      840

aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg      900

aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag      960

cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc     1020

cagtccaagc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc     1080

gtgaccgccg ccgggatcac tctcggcatg gacgaactgt acaagtag                  1128


<210>  31
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  31

Met Gly Asp Val Phe Leu Met Ile Arg Arg His Lys Thr Thr Ile Phe 
1               5                   10                  15      


Thr Asp Ala Lys Glu Ser Ser Thr Val Phe Glu Leu Lys Arg Ile Val 
            20                  25                  30          


Glu Gly Ile Leu Lys Arg Pro Pro Asp Glu Gln Arg Leu Tyr Lys Asp 
        35                  40                  45              


Asp Gln Leu Leu Asp Asp Gly Lys Thr Leu Gly Glu Cys Gly Phe Thr 
    50                  55                  60                  


Ser Gln Thr Ala Arg Pro Gln Ala Pro Ala Thr Val Gly Leu Ala Phe 
65                  70                  75                  80  


Arg Ala Asp Asp Thr Phe Glu Ala Leu Cys Ile Glu Pro Phe Ser Ser 
                85                  90                  95      


Pro Pro Glu Leu Pro Asp Val Met Lys Pro Gln Asp Ser Gly Ser Ser 
            100                 105                 110         


Ala Asn Glu Gln Ala Val Gln Ser Arg Gly Lys Pro Ile Pro Asn Pro 
        115                 120                 125             


Leu Leu Gly Leu Asp Ser Thr Asp Ile Val Ser Lys Gly Glu Glu Leu 
    130                 135                 140                 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
145                 150                 155                 160 


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
                165                 170                 175     


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
            180                 185                 190         


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe 
        195                 200                 205             


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
    210                 215                 220                 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
225                 230                 235                 240 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
                245                 250                 255     


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
            260                 265                 270         


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
        275                 280                 285             


Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
    290                 295                 300                 


Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
305                 310                 315                 320 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
                325                 330                 335     


Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg 
            340                 345                 350         


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
        355                 360                 365             


Gly Met Asp Glu Leu Tyr Lys 
    370                 375 


<210>  32
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  32
atgggacatc accatcacca tcacctggaa gttctgttcc aggggccccc gcgcgtcgtg       60

cccgaccaga gaagcaagtt cgagaacgag gagtttttta ggaagctgag ccgcgagtgt      120

gagattaagt acacgggctt cagggaccgg ccccacgagg aacgccaggc acgcttccag      180

aacgcctgcc gcgacggccg ctcggaaatc gcttttgtgg ccacaggaac caatctgtct      240

ctccagtttt ttccggccag ctggcaggga gaacagcgac aaacacctag ccgagagtat      300

gtcgacttag aaagagaagc aggcaaggta tatttgaagg ctcccatgat tctgaatgga      360

gtctgtgtta tctggaaagg ctggattgat ctccaaagac tggatggtat gggctgtctg      420

gagtttgatg aggagcgagc ccagcaggag gatgcattag cacaacaggc ctttgaagag      480

gctcggagaa ggacacgcga atttgaagat agagacaggt ctcatcggga ggaaatggag      540

gtgagagttt cacagctgct ggcagtaact ggcaagaaga caacaagacc cggagaattc      600

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc      660

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc      720

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc      780

gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag      840

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc      900

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg      960

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag     1020

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc     1080

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac     1140

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac     1200

ctgagcaccc agtccaagct gagcaaagac cccaacgaga agcgcgatca catggtcctg     1260

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgaactgta caagtag        1317


<210>  33
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  33

Met Gly His His His His His His Leu Glu Val Leu Phe Gln Gly Pro 
1               5                   10                  15      


Pro Arg Val Val Pro Asp Gln Arg Ser Lys Phe Glu Asn Glu Glu Phe 
            20                  25                  30          


Phe Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Thr Gly Phe Arg 
        35                  40                  45              


Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys Arg 
    50                  55                  60                  


Asp Gly Arg Ser Glu Ile Ala Phe Val Ala Thr Gly Thr Asn Leu Ser 
65                  70                  75                  80  


Leu Gln Phe Phe Pro Ala Ser Trp Gln Gly Glu Gln Arg Gln Thr Pro 
                85                  90                  95      


Ser Arg Glu Tyr Val Asp Leu Glu Arg Glu Ala Gly Lys Val Tyr Leu 
            100                 105                 110         


Lys Ala Pro Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly Trp 
        115                 120                 125             


Ile Asp Leu Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp Glu 
    130                 135                 140                 


Glu Arg Ala Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu Glu 
145                 150                 155                 160 


Ala Arg Arg Arg Thr Arg Glu Phe Glu Asp Arg Asp Arg Ser His Arg 
                165                 170                 175     


Glu Glu Met Glu Val Arg Val Ser Gln Leu Leu Ala Val Thr Gly Lys 
            180                 185                 190         


Lys Thr Thr Arg Pro Gly Glu Phe Val Ser Lys Gly Glu Glu Leu Phe 
        195                 200                 205             


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
    210                 215                 220                 


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
225                 230                 235                 240 


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
                245                 250                 255     


Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser 
            260                 265                 270         


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
        275                 280                 285             


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
    290                 295                 300                 


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
305                 310                 315                 320 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
                325                 330                 335     


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
            340                 345                 350         


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
        355                 360                 365             


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
    370                 375                 380                 


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
385                 390                 395                 400 


Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
                405                 410                 415     


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
            420                 425                 430         


Met Asp Glu Leu Tyr Lys 
        435             


<210>  34
<211>  1305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  34
atgggagaaa acagatggca ggtgatgatt gtgtggcaag tagacaggat gaggattaga       60

acatggaaaa gtttagtaaa acaccatatg tatgtttcag ggaaagctag gggatggttt      120

tatagacatc actatgaaag ccctcatcca agaataagtt cagaagtaca catcccacta      180

ggggatgcta gattggtaat aacaacatat tggggtctgc atacaggaga aagagactgg      240

catctgggtc agggagtctc catagaatgg aggaaaaaga gatatagcac acaagtagac      300

cctgaactag cagaccaact aattcatctg tattactttg actgtttttc agactctgct      360

ataagaaagg ccttattagg acatatagtt agccctaggt gtgaatatca agcaggacat      420

aacaaggtag gatctctaca atacttggca ctagcagcat taataacacc aaaaaagata      480

aagccacctt tgcctagtgt tacgaaactg acagaggata gatggaacaa gccccagaag      540

accaagggcc acagagggag ccacacaatg aatggacacg gagaattcgt gagcaagggc      600

gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc      660

cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg      720

aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg      780

acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca cgacttcttc      840

aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc      900

aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag      960

ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac     1020

tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac     1080

ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag     1140

aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag     1200

tccaagctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg     1260

accgccgccg ggatcactct cggcatggac gaactgtaca agtag                     1305


<210>  35
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  35

Met Gly Glu Asn Arg Trp Gln Val Met Ile Val Trp Gln Val Asp Arg 
1               5                   10                  15      


Met Arg Ile Arg Thr Trp Lys Ser Leu Val Lys His His Met Tyr Val 
            20                  25                  30          


Ser Gly Lys Ala Arg Gly Trp Phe Tyr Arg His His Tyr Glu Ser Pro 
        35                  40                  45              


His Pro Arg Ile Ser Ser Glu Val His Ile Pro Leu Gly Asp Ala Arg 
    50                  55                  60                  


Leu Val Ile Thr Thr Tyr Trp Gly Leu His Thr Gly Glu Arg Asp Trp 
65                  70                  75                  80  


His Leu Gly Gln Gly Val Ser Ile Glu Trp Arg Lys Lys Arg Tyr Ser 
                85                  90                  95      


Thr Gln Val Asp Pro Glu Leu Ala Asp Gln Leu Ile His Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Cys Phe Ser Asp Ser Ala Ile Arg Lys Ala Leu Leu Gly His 
        115                 120                 125             


Ile Val Ser Pro Arg Cys Glu Tyr Gln Ala Gly His Asn Lys Val Gly 
    130                 135                 140                 


Ser Leu Gln Tyr Leu Ala Leu Ala Ala Leu Ile Thr Pro Lys Lys Ile 
145                 150                 155                 160 


Lys Pro Pro Leu Pro Ser Val Thr Lys Leu Thr Glu Asp Arg Trp Asn 
                165                 170                 175     


Lys Pro Gln Lys Thr Lys Gly His Arg Gly Ser His Thr Met Asn Gly 
            180                 185                 190         


His Gly Glu Phe Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
        195                 200                 205             


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
    210                 215                 220                 


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
225                 230                 235                 240 


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
                245                 250                 255     


Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
            260                 265                 270         


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
        275                 280                 285             


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
    290                 295                 300                 


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
305                 310                 315                 320 


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
                325                 330                 335     


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
            340                 345                 350         


Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu 
        355                 360                 365             


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
    370                 375                 380                 


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
385                 390                 395                 400 


Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
                405                 410                 415     


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
            420                 425                 430         


Tyr Lys 
        


<210>  36
<211>  2613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  36
atgggctccc ctatactagg ttattggaaa attaagggcc ttgtgcaacc cactcgactt       60

cttttggaat atcttgaaga aaaatatgaa gagcatttgt atgagcgcga tgaaggtgat      120

aaatggcgaa acaaaaagtt tgaattgggt ttggagtttc ccaatcttcc ttattatatt      180

gatggtgatg ttaaattaac acagtctatg gccatcatac gttatatagc tgacaagcac      240

aacatgttgg gtggttgtcc aaaagagcgt gcagagattt caatgcttga aggagcggtt      300

ttggatatta gatacggtgt ttcgagaatt gcatatagta aagactttga aactctcaaa      360

gttgattttc ttagcaagct acctgaaatg ctgaaaatgt tcgaagatcg tttatgtcat      420

aaaacatatt taaatggtga tcatgtaacc catcctgact tcatgttgta tgacgctctt      480

gatgttgttt tatacatgga cccaatgtgc ctggatgcgt tcccaaaatt agtttgtttt      540

aaaaaacgta ttgaagctat cccacaaatt gataagtact tgaaatccag caagtatata      600

gcatggcctt tgcagggctg gcaagccacg tttggtggtg gcgaccatcc tccaaaatcg      660

gatctggaag ttctgttcca ggggcccctg catatgggag gatccacgtc taatctgtta      720

aagaataaag gttctcttca gtttgaagac aaatgggatt ttatgcgccc gattgttttg      780

aagcttttac gccaggaatc tgttacaaaa cagcagtggt ttgatctgtt ttcggatgtg      840

catgcagtct gtctttggga tgataaaggc ccagcaaaaa ttcatcaggc tttaaaagaa      900

gatattcttg agtttattaa gcaggcacag gcacgagtac tgagccatca agatgatacg      960

gctttgctaa aagcatatat tgttgaatgg cgaaagttct ttacacaatg tgatatttta     1020

ccaaaacctt tttgtcaact agagattact ttaatgggta aacagggcag caataaaaaa     1080

tcaaatgtgg aagacagtat tgttcgaaag cttatgcttg atacatggaa tgagtcaatc     1140

ttttcaaaca taaaaaacag actccaagat agtgcaatga agctggtaca tgctgagaga     1200

ttgggagaag cttttgattc tcagctggtt attggagtaa gagaatccta tgttaacctt     1260

tgttctaatc ctgaggataa acttcaaatt tatagggaca attttgagaa ggcatacttg     1320

gattcaacag agagatttta tagaacacaa gcaccctcgt atttacaaca aaatggtgta     1380

cagaattata tgaaatatgc agatgctaaa ttaaaagaag aagaaaaacg agcactacgt     1440

tatttagaaa caagacgaga atgtaactcc gttgaagcac tcatggaatg ctgtgtaaat     1500

gccctggtga catcatttaa agagactatc ttagctgagt gccaaggcat gatcaagaga     1560

aatgaaactg aaaaattaca tttaatgttt tcattgatgg acaaagttcc taatggtata     1620

gagccaatgt tgaaagactt ggaggaacat atcattagtg ctggcctggc agatatggta     1680

gcagctgctg aaactattac tactgactct gagaaatacc gtgagcagtt agatacacta     1740

tttaatagat ttagtaaact cgtcaaagaa gcttttcaag atgatccacg atttcttact     1800

gcaagagata aggcgtataa agcagttgtt aatgatgcta ccatatttaa atctagaggc     1860

ggttacccct acgacgtgcc cgactacgcc gatatcgtga gcaagggcga ggagctgttc     1920

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc     1980

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttaatctgc     2040

accaccggca agctgcccgt gccctggccc accctcgtga ccaccttcgg ctacggcctg     2100

atgtgcttcg cccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg     2160

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc     2220

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc     2280

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaactg gaacagcgtc     2340

aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc     2400

cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc     2460

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gctaccagtc cgccctgagc     2520

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agcgcgtgac cgccgccggg     2580

atcactctcg gcatggacga gctgtacaag tag                                  2613


<210>  37
<211>  870
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  37

Met Gly Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln 
1               5                   10                  15      


Pro Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His 
            20                  25                  30          


Leu Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu 
        35                  40                  45              


Leu Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val 
    50                  55                  60                  


Lys Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His 
65                  70                  75                  80  


Asn Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu 
                85                  90                  95      


Glu Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr 
            100                 105                 110         


Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro 
        115                 120                 125             


Glu Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu 
    130                 135                 140                 


Asn Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu 
145                 150                 155                 160 


Asp Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys 
                165                 170                 175     


Leu Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys 
            180                 185                 190         


Tyr Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln 
        195                 200                 205             


Ala Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val 
    210                 215                 220                 


Leu Phe Gln Gly Pro Leu His Met Gly Gly Ser Thr Ser Asn Leu Leu 
225                 230                 235                 240 


Lys Asn Lys Gly Ser Leu Gln Phe Glu Asp Lys Trp Asp Phe Met Arg 
                245                 250                 255     


Pro Ile Val Leu Lys Leu Leu Arg Gln Glu Ser Val Thr Lys Gln Gln 
            260                 265                 270         


Trp Phe Asp Leu Phe Ser Asp Val His Ala Val Cys Leu Trp Asp Asp 
        275                 280                 285             


Lys Gly Pro Ala Lys Ile His Gln Ala Leu Lys Glu Asp Ile Leu Glu 
    290                 295                 300                 


Phe Ile Lys Gln Ala Gln Ala Arg Val Leu Ser His Gln Asp Asp Thr 
305                 310                 315                 320 


Ala Leu Leu Lys Ala Tyr Ile Val Glu Trp Arg Lys Phe Phe Thr Gln 
                325                 330                 335     


Cys Asp Ile Leu Pro Lys Pro Phe Cys Gln Leu Glu Ile Thr Leu Met 
            340                 345                 350         


Gly Lys Gln Gly Ser Asn Lys Lys Ser Asn Val Glu Asp Ser Ile Val 
        355                 360                 365             


Arg Lys Leu Met Leu Asp Thr Trp Asn Glu Ser Ile Phe Ser Asn Ile 
    370                 375                 380                 


Lys Asn Arg Leu Gln Asp Ser Ala Met Lys Leu Val His Ala Glu Arg 
385                 390                 395                 400 


Leu Gly Glu Ala Phe Asp Ser Gln Leu Val Ile Gly Val Arg Glu Ser 
                405                 410                 415     


Tyr Val Asn Leu Cys Ser Asn Pro Glu Asp Lys Leu Gln Ile Tyr Arg 
            420                 425                 430         


Asp Asn Phe Glu Lys Ala Tyr Leu Asp Ser Thr Glu Arg Phe Tyr Arg 
        435                 440                 445             


Thr Gln Ala Pro Ser Tyr Leu Gln Gln Asn Gly Val Gln Asn Tyr Met 
    450                 455                 460                 


Lys Tyr Ala Asp Ala Lys Leu Lys Glu Glu Glu Lys Arg Ala Leu Arg 
465                 470                 475                 480 


Tyr Leu Glu Thr Arg Arg Glu Cys Asn Ser Val Glu Ala Leu Met Glu 
                485                 490                 495     


Cys Cys Val Asn Ala Leu Val Thr Ser Phe Lys Glu Thr Ile Leu Ala 
            500                 505                 510         


Glu Cys Gln Gly Met Ile Lys Arg Asn Glu Thr Glu Lys Leu His Leu 
        515                 520                 525             


Met Phe Ser Leu Met Asp Lys Val Pro Asn Gly Ile Glu Pro Met Leu 
    530                 535                 540                 


Lys Asp Leu Glu Glu His Ile Ile Ser Ala Gly Leu Ala Asp Met Val 
545                 550                 555                 560 


Ala Ala Ala Glu Thr Ile Thr Thr Asp Ser Glu Lys Tyr Arg Glu Gln 
                565                 570                 575     


Leu Asp Thr Leu Phe Asn Arg Phe Ser Lys Leu Val Lys Glu Ala Phe 
            580                 585                 590         


Gln Asp Asp Pro Arg Phe Leu Thr Ala Arg Asp Lys Ala Tyr Lys Ala 
        595                 600                 605             


Val Val Asn Asp Ala Thr Ile Phe Lys Ser Arg Gly Gly Tyr Pro Tyr 
    610                 615                 620                 


Asp Val Pro Asp Tyr Ala Asp Ile Val Ser Lys Gly Glu Glu Leu Phe 
625                 630                 635                 640 


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
                645                 650                 655     


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
            660                 665                 670         


Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
        675                 680                 685             


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Met Cys Phe Ala 
    690                 695                 700                 


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
705                 710                 715                 720 


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
                725                 730                 735     


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
            740                 745                 750         


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
        755                 760                 765             


Leu Gly His Lys Leu Glu Tyr Asn Trp Asn Ser Val Asn Val Tyr Ile 
    770                 775                 780                 


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
785                 790                 795                 800 


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
                805                 810                 815     


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
            820                 825                 830         


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
        835                 840                 845             


His Met Val Leu Leu Glu Arg Val Thr Ala Ala Gly Ile Thr Leu Gly 
    850                 855                 860                 


Met Asp Glu Leu Tyr Lys 
865                 870 


<210>  38
<211>  1938
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  38
atgggacatc accatcacca tcacgtgagc aagggcgagg agctgttcac cggggtggtg       60

cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt gtccggcgag      120

ggcgagggcg atgccaccta cggcaagctg accctgaagt taatctgcac caccggcaag      180

ctgcccgtgc cctggcccac cctcgtgacc accttcggct acggcctgat gtgcttcgcc      240

cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac      300

gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg      360

aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga cttcaaggag      420

gacggcaaca tcctggggca caagctggag tacaactgga acagcgtcaa cgtctatatc      480

atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca caacatcgag      540

gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc      600

gtgctgctgc ccgacaacca ctacctgagc taccagtccg ccctgagcaa agaccccaac      660

gagaagcgcg atcacatggt cctgctggag cgcgtgaccg ccgccgggat cactctcggc      720

atggacgagc tgtacaagca ggaattcctg gaagttctgt tccaggggcc cggtggtagt      780

ggtggatcca cgtctaatct gttaaagaat aaaggttctc ttcagtttga agacaaatgg      840

gattttatgc gcccgattgt tttgaagctt ttacgccagg aatctgttac aaaacagcag      900

tggtttgatc tgttttcgga tgtgcatgca gtctgtcttt gggatgataa aggcccagca      960

aaaattcatc aggctttaaa agaagatatt cttgagttta ttaagcaggc acaggcacga     1020

gtactgagcc atcaagatga tacggctttg ctaaaagcat atattgttga atggcgaaag     1080

ttctttacac aatgtgatat tttaccaaaa cctttttgtc aactagagat tactttaatg     1140

ggtaaacagg gcagcaataa aaaatcaaat gtggaagaca gtattgttcg aaagcttatg     1200

cttgatacat ggaatgagtc aatcttttca aacataaaaa acagactcca agatagtgca     1260

atgaagctgg tacatgctga gagattggga gaagcttttg attctcagct ggttattgga     1320

gtaagagaat cctatgttaa cctttgttct aatcctgagg ataaacttca aatttatagg     1380

gacaattttg agaaggcata cttggattca acagagagat tttatagaac acaagcaccc     1440

tcgtatttac aacaaaatgg tgtacagaat tatatgaaat atgcagatgc taaattaaaa     1500

gaagaagaaa aacgagcact acgttattta gaaacaagac gagaatgtaa ctccgttgaa     1560

gcactcatgg aatgctgtgt aaatgccctg gtgacatcat ttaaagagac tatcttagct     1620

gagtgccaag gcatgatcaa gagaaatgaa actgaaaaat tacatttaat gttttcattg     1680

atggacaaag ttcctaatgg tatagagcca atgttgaaag acttggagga acatatcatt     1740

agtgctggcc tggcagatat ggtagcagct gctgaaacta ttactactga ctctgagaaa     1800

taccgtgagc agttagatac actatttaat agatttagta aactcgtcaa agaagctttt     1860

caagatgatc cacgatttct tactgcaaga gataaggcgt ataaagcagt tgttaatgat     1920

gctaccatat ttaaataa                                                   1938


<210>  39
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  39

Met Gly His His His His His His Val Ser Lys Gly Glu Glu Leu Phe 
1               5                   10                  15      


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
            20                  25                  30          


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
        35                  40                  45              


Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
    50                  55                  60                  


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Met Cys Phe Ala 
65                  70                  75                  80  


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
                85                  90                  95      


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
            100                 105                 110         


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
        115                 120                 125             


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
    130                 135                 140                 


Leu Gly His Lys Leu Glu Tyr Asn Trp Asn Ser Val Asn Val Tyr Ile 
145                 150                 155                 160 


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
                165                 170                 175     


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
            180                 185                 190         


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
        195                 200                 205             


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
    210                 215                 220                 


His Met Val Leu Leu Glu Arg Val Thr Ala Ala Gly Ile Thr Leu Gly 
225                 230                 235                 240 


Met Asp Glu Leu Tyr Lys Gln Glu Phe Leu Glu Val Leu Phe Gln Gly 
                245                 250                 255     


Pro Gly Gly Ser Gly Gly Ser Thr Ser Asn Leu Leu Lys Asn Lys Gly 
            260                 265                 270         


Ser Leu Gln Phe Glu Asp Lys Trp Asp Phe Met Arg Pro Ile Val Leu 
        275                 280                 285             


Lys Leu Leu Arg Gln Glu Ser Val Thr Lys Gln Gln Trp Phe Asp Leu 
    290                 295                 300                 


Phe Ser Asp Val His Ala Val Cys Leu Trp Asp Asp Lys Gly Pro Ala 
305                 310                 315                 320 


Lys Ile His Gln Ala Leu Lys Glu Asp Ile Leu Glu Phe Ile Lys Gln 
                325                 330                 335     


Ala Gln Ala Arg Val Leu Ser His Gln Asp Asp Thr Ala Leu Leu Lys 
            340                 345                 350         


Ala Tyr Ile Val Glu Trp Arg Lys Phe Phe Thr Gln Cys Asp Ile Leu 
        355                 360                 365             


Pro Lys Pro Phe Cys Gln Leu Glu Ile Thr Leu Met Gly Lys Gln Gly 
    370                 375                 380                 


Ser Asn Lys Lys Ser Asn Val Glu Asp Ser Ile Val Arg Lys Leu Met 
385                 390                 395                 400 


Leu Asp Thr Trp Asn Glu Ser Ile Phe Ser Asn Ile Lys Asn Arg Leu 
                405                 410                 415     


Gln Asp Ser Ala Met Lys Leu Val His Ala Glu Arg Leu Gly Glu Ala 
            420                 425                 430         


Phe Asp Ser Gln Leu Val Ile Gly Val Arg Glu Ser Tyr Val Asn Leu 
        435                 440                 445             


Cys Ser Asn Pro Glu Asp Lys Leu Gln Ile Tyr Arg Asp Asn Phe Glu 
    450                 455                 460                 


Lys Ala Tyr Leu Asp Ser Thr Glu Arg Phe Tyr Arg Thr Gln Ala Pro 
465                 470                 475                 480 


Ser Tyr Leu Gln Gln Asn Gly Val Gln Asn Tyr Met Lys Tyr Ala Asp 
                485                 490                 495     


Ala Lys Leu Lys Glu Glu Glu Lys Arg Ala Leu Arg Tyr Leu Glu Thr 
            500                 505                 510         


Arg Arg Glu Cys Asn Ser Val Glu Ala Leu Met Glu Cys Cys Val Asn 
        515                 520                 525             


Ala Leu Val Thr Ser Phe Lys Glu Thr Ile Leu Ala Glu Cys Gln Gly 
    530                 535                 540                 


Met Ile Lys Arg Asn Glu Thr Glu Lys Leu His Leu Met Phe Ser Leu 
545                 550                 555                 560 


Met Asp Lys Val Pro Asn Gly Ile Glu Pro Met Leu Lys Asp Leu Glu 
                565                 570                 575     


Glu His Ile Ile Ser Ala Gly Leu Ala Asp Met Val Ala Ala Ala Glu 
            580                 585                 590         


Thr Ile Thr Thr Asp Ser Glu Lys Tyr Arg Glu Gln Leu Asp Thr Leu 
        595                 600                 605             


Phe Asn Arg Phe Ser Lys Leu Val Lys Glu Ala Phe Gln Asp Asp Pro 
    610                 615                 620                 


Arg Phe Leu Thr Ala Arg Asp Lys Ala Tyr Lys Ala Val Val Asn Asp 
625                 630                 635                 640 


Ala Thr Ile Phe Lys 
                645 


<210>  40
<211>  1506
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  40
atgggacatc accatcacca tcacgtgagc aagggcgagg agctgttcac cggggtggtg       60

cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt gtccggcgag      120

ggcgagggcg atgccaccta cggcaagctg accctgaagt taatctgcac caccggcaag      180

ctgcccgtgc cctggcccac cctcgtgacc accttcggct acggcctgat gtgcttcgcc      240

cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac      300

gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg      360

aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga cttcaaggag      420

gacggcaaca tcctggggca caagctggag tacaactgga acagcgtcaa cgtctatatc      480

atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca caacatcgag      540

gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc      600

gtgctgctgc ccgacaacca ctacctgagc taccagtccg ccctgagcaa agaccccaac      660

gagaagcgcg atcacatggt cctgctggag cgcgtgaccg ccgccgggat cactctcggc      720

atggacgagc tgtacaagca ggaattcctg gaagttctgt tccaggggcc cggtggtagt      780

ggtggatccg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag      840

ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc      900

acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg      960

cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac     1020

atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc     1080

atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac     1140

accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg     1200

gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag     1260

aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag     1320

ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac     1380

aaccactacc tgagcaccca gtccaagctg agcaaagacc ccaacgagaa gcgcgatcac     1440

atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgaactgtac     1500

aagtag                                                                1506


<210>  41
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  41

Met Gly His His His His His His Val Ser Lys Gly Glu Glu Leu Phe 
1               5                   10                  15      


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
            20                  25                  30          


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
        35                  40                  45              


Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
    50                  55                  60                  


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Met Cys Phe Ala 
65                  70                  75                  80  


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
                85                  90                  95      


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
            100                 105                 110         


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
        115                 120                 125             


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
    130                 135                 140                 


Leu Gly His Lys Leu Glu Tyr Asn Trp Asn Ser Val Asn Val Tyr Ile 
145                 150                 155                 160 


Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg 
                165                 170                 175     


His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
            180                 185                 190         


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
        195                 200                 205             


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
    210                 215                 220                 


His Met Val Leu Leu Glu Arg Val Thr Ala Ala Gly Ile Thr Leu Gly 
225                 230                 235                 240 


Met Asp Glu Leu Tyr Lys Gln Glu Phe Leu Glu Val Leu Phe Gln Gly 
                245                 250                 255     


Pro Gly Gly Ser Gly Gly Ser Val Ser Lys Gly Glu Glu Leu Phe Thr 
            260                 265                 270         


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
        275                 280                 285             


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
    290                 295                 300                 


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
305                 310                 315                 320 


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg 
                325                 330                 335     


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
            340                 345                 350         


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
        355                 360                 365             


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
    370                 375                 380                 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
385                 390                 395                 400 


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met 
                405                 410                 415     


Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His 
            420                 425                 430         


Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
        435                 440                 445             


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
    450                 455                 460                 


Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
465                 470                 475                 480 


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
                485                 490                 495     


Asp Glu Leu Tyr Lys 
            500     


<210>  42
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  42
ctggaagttc tgttccaggg gcccggtggt agtggtggat cc                          42


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  43

Leu Glu Val Leu Phe Gln Gly Pro Gly Gly Ser Gly Gly Ser 
1               5                   10                  


