                         SEQUENCE LISTING

<110>  Regado Biosciences Inc.
            Novamedica
 
<120>  Nucleic Acid Modulators of Growth Arrest-Specific Protein 6

<130>  10815.8014.WO

<150>  61/717,949
<151>  2012-10-24

<160>  194   

<170>  PatentIn version 3.5

<210>  1
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 
            20                  25                  30          


Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 
        35                  40                  45              


Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 
    50                  55                  60                  


Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu 
65                  70                  75                  80  


Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp Cys Ile 
                85                  90                  95      


Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys 
            100                 105                 110         


Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys 
        115                 120                 125             


Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys Leu Cys 
    130                 135                 140                 


Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys 
145                 150                 155                 160 


Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys Pro Gly 
                165                 170                 175     


Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly 
        195                 200                 205             


Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp 
    210                 215                 220                 


Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp Val Asp 
225                 230                 235                 240 


Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser Pro Gly 
                245                 250                 255     


Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln 
            260                 265                 270         


Asp Met Asp Thr Cys Glu Leu Glu Ala Gly Trp Pro Cys Pro Arg His 
        275                 280                 285             


Arg Arg Asp Gly Ser Pro Ala Ala Arg Pro Gly Arg Gly Ala Gln Gly 
    290                 295                 300                 


Ser Arg Ser Glu Gly His Ile Pro Asp Arg Arg Gly Pro Arg Pro Trp 
305                 310                 315                 320 


Gln Asp Ile Leu Pro Cys Val Pro Phe Ser Val Ala Lys Ser Val Lys 
                325                 330                 335     


Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr Pro Val Ile Arg Leu 
            340                 345                 350         


Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val Ala Glu Phe Asp Phe 
        355                 360                 365             


Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe Ala Gly Gly His Gln 
    370                 375                 380                 


Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala Gly Arg Leu Glu Leu 
385                 390                 395                 400 


Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr Ser Ser Gly Pro Val 
                405                 410                 415     


Ile Asn His Gly Met Trp Gln Thr Ile Ser Val Glu Glu Leu Ala Arg 
            420                 425                 430         


Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val Met Lys Ile Ala Val 
        435                 440                 445             


Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu Tyr His Leu Asn Leu 
    450                 455                 460                 


Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp Leu Val Gln Pro Ile 
465                 470                 475                 480 


Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp Asn Trp Leu Asn Gly 
                485                 490                 495     


Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val Asn Thr Arg Met Gln 
            500                 505                 510         


Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr Pro Gly Ser Gly Phe 
        515                 520                 525             


Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro Leu Asp Val Gly Thr 
    530                 535                 540                 


Glu Ser Thr Trp Glu Val Glu Val Val Ala His Ile Arg Pro Ala Ala 
545                 550                 555                 560 


Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro Asp Leu Arg Ala Val 
                565                 570                 575     


Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser Thr Lys Lys Leu Lys 
            580                 585                 590         


Lys Gln Leu Val Val Leu Ala Val Glu His Thr Ala Leu Ala Leu Met 
        595                 600                 605             


Glu Ile Lys Val Cys Asp Gly Gln Glu His Val Val Thr Val Ser Leu 
    610                 615                 620                 


Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly Thr Arg Gly Gln Ser 
625                 630                 635                 640 


Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu Ala Val Leu Glu Arg 
                645                 650                 655     


His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly Gly Leu Pro Asp Val 
            660                 665                 670         


Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr Arg Gly Cys Met Thr 
        675                 680                 685             


Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp Glu Ala Ala Tyr Lys 
    690                 695                 700                 


His Ser Asp Ile Thr Ala His Ser Cys Pro Pro Val Glu Pro Ala Ala 
705                 710                 715                 720 


<210>  2
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal His6 fusion to GAS6

<400>  2

Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 
            20                  25                  30          


Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 
        35                  40                  45              


Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 
    50                  55                  60                  


Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu 
65                  70                  75                  80  


Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp Cys Ile 
                85                  90                  95      


Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys 
            100                 105                 110         


Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys 
        115                 120                 125             


Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys Leu Cys 
    130                 135                 140                 


Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys 
145                 150                 155                 160 


Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys Pro Gly 
                165                 170                 175     


Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly 
        195                 200                 205             


Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp 
    210                 215                 220                 


Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp Val Asp 
225                 230                 235                 240 


Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser Pro Gly 
                245                 250                 255     


Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln 
            260                 265                 270         


Asp Met Asp Thr Cys Glu Leu Glu Ala Gly Trp Pro Cys Pro Arg His 
        275                 280                 285             


Arg Arg Asp Gly Ser Pro Ala Ala Arg Pro Gly Arg Gly Ala Gln Gly 
    290                 295                 300                 


Ser Arg Ser Glu Gly His Ile Pro Asp Arg Arg Gly Pro Arg Pro Trp 
305                 310                 315                 320 


Gln Asp Ile Leu Pro Cys Val Pro Phe Ser Val Ala Lys Ser Val Lys 
                325                 330                 335     


Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr Pro Val Ile Arg Leu 
            340                 345                 350         


Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val Ala Glu Phe Asp Phe 
        355                 360                 365             


Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe Ala Gly Gly His Gln 
    370                 375                 380                 


Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala Gly Arg Leu Glu Leu 
385                 390                 395                 400 


Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr Ser Ser Gly Pro Val 
                405                 410                 415     


Ile Asn His Gly Met Trp Gln Thr Ile Ser Val Glu Glu Leu Ala Arg 
            420                 425                 430         


Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val Met Lys Ile Ala Val 
        435                 440                 445             


Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu Tyr His Leu Asn Leu 
    450                 455                 460                 


Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp Leu Val Gln Pro Ile 
465                 470                 475                 480 


Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp Asn Trp Leu Asn Gly 
                485                 490                 495     


Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val Asn Thr Arg Met Gln 
            500                 505                 510         


Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr Pro Gly Ser Gly Phe 
        515                 520                 525             


Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro Leu Asp Val Gly Thr 
    530                 535                 540                 


Glu Ser Thr Trp Glu Val Glu Val Val Ala His Ile Arg Pro Ala Ala 
545                 550                 555                 560 


Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro Asp Leu Arg Ala Val 
                565                 570                 575     


Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser Thr Lys Lys Leu Lys 
            580                 585                 590         


Lys Gln Leu Val Val Leu Ala Val Glu His Thr Ala Leu Ala Leu Met 
        595                 600                 605             


Glu Ile Lys Val Cys Asp Gly Gln Glu His Val Val Thr Val Ser Leu 
    610                 615                 620                 


Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly Thr Arg Gly Gln Ser 
625                 630                 635                 640 


Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu Ala Val Leu Glu Arg 
                645                 650                 655     


His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly Gly Leu Pro Asp Val 
            660                 665                 670         


Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr Arg Gly Cys Met Thr 
        675                 680                 685             


Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp Glu Ala Ala Tyr Lys 
    690                 695                 700                 


His Ser Asp Ile Thr Ala His Ser Cys Pro Pro Val Glu Pro Ala Ala 
705                 710                 715                 720 


<210>  3
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA template oligonucleotide


<220>
<221>  misc_feature
<222>  (25)..(59)
<223>  n is a, c, g, or t

<400>  3
catcgatgct agtcgtaacg atccnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc       60

gagaacgtta ttgtactccc cta                                               83


<210>  4
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  4
gggggaattc taatacgact cactataggg gagtacaata acgttctcg                   49


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
catcgatgct agtcgtaacg atcc                                              24


<210>  6
<211>  80
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  6
ggggagtaca ataacgttct cgacctgtgt acatccgccg tcgagattgc tcccccggat       60

cgttacgact agcatcgatg                                                   80


<210>  7
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  7
ggggagtaca ataacgttct cgccgcggtc tatgagccac ctgtgtacat ccgccgtgga       60

tcgttacgac tagcatcgat g                                                 81


<210>  8
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  8
ggggagtaca ataacgttct cgcccgtcgc tatgcttggc tgctagatcc gaccccggga       60

tcgttacgac tagcatcgat g                                                 81


<210>  9
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  9
ggggagtaca ataacgttct cggaatcggg gttcgaaacc gaactcgctc cacgccggga       60

tcgttacgac tagcatcgat g                                                 81


<210>  10
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  10
acctgtgtac atccgccgtc gagattgctc cccc                                   34


<210>  11
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  11
ccgcggtcta tgagccacct gtgtacatcc gccgt                                  35


<210>  12
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  12
cccgtcgcta tgcttggctg ctagatccga ccccg                                  35


<210>  13
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  13
gaatcggggt tcgaaaccga actcgctcca cgccg                                  35


<210>  14
<211>  80
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  14
ggggaguaca auaacguucu cgaccugugu acauccgccg ucgagauugc ucccccggau       60

cguuacgacu agcaucgaug                                                   80


<210>  15
<211>  81
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  15
ggggaguaca auaacguucu cgccgcgguc uaugagccac cuguguacau ccgccgugga       60

ucguuacgac uagcaucgau g                                                 81


<210>  16
<211>  81
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  16
ggggaguaca auaacguucu cgcccgucgc uaugcuuggc ugcuagaucc gaccccggga       60

ucguuacgac uagcaucgau g                                                 81


<210>  17
<211>  81
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  17
ggggaguaca auaacguucu cggaaucggg guucgaaacc gaacucgcuc cacgccggga       60

ucguuacgac uagcaucgau g                                                 81


<210>  18
<211>  80
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(80)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  18
ggggaguaca auaacguucu cgaccugugu acauccgccg ucgagauugc ucccccggau       60

cguuacgacu agcaucgaug                                                   80


<210>  19
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
ggggaguaca auaacguucu cgccgcgguc uaugagccac cuguguacau ccgccgugga       60

ucguuacgac uagcaucgau g                                                 81


<210>  20
<211>  81
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(81)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  20
ggggaguaca auaacguucu cgcccgucgc uaugcuuggc ugcuagaucc gaccccggga       60

ucguuacgac uagcaucgau g                                                 81


<210>  21
<211>  81
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  21
ggggaguaca auaacguucu cggaaucggg guucgaaacc gaacucgcuc cacgccggga       60

ucguuacgac uagcaucgau g                                                 81


<210>  22
<211>  81
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  22
ggggaguaca auaacguucu cgccccucgu gucgccggua ccuaagcgcu cggccaugga       60

ucguuacgac uagcaucgau g                                                 81


<210>  23
<211>  34
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  23
accuguguac auccgccguc gagauugcuc cccc                                   34


<210>  24
<211>  35
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  24
ccgcggucua ugagccaccu guguacaucc gccgu                                  35


<210>  25
<211>  35
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  25
cccgucgcua ugcuuggcug cuagauccga ccccg                                  35


<210>  26
<211>  35
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  26
gaaucggggu ucgaaaccga acucgcucca cgccg                                  35


<210>  27
<211>  81
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  27
ggggaguaca auaacguucu cgaaaacugc acacccgcac ugaucgggag guggagcgga       60

ucguuacgac uagcaucgau g                                                 81


<210>  28
<211>  81
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  28
ggggaguaca auaacguucu cggcgcccca uccaaacgug ugggugggcu gacagcggga       60

ucguuacgac uagcaucgau g                                                 81


<210>  29
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  29
ucucggaauc gggguucgaa accgaacucg cuccacgccg gga                         43


<210>  30
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  30
ucucggaauc gggguucgaa accgaacucg cuccacgccg gga                         43


<210>  31
<211>  42
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  31
ucucggaauc gggguucgaa ccgaacucgc uccacgccgg ga                          42


<210>  32
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  32
ucucggaauc gggguucgaa aacgaacucg cuccacgccg gga                         43


<210>  33
<211>  44
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  33
ucucggaauc gggguucgaa accgaacucg cuccacgccg ggga                        44


<210>  34
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  34
ucucggaauc gggguucgaa accgaacucg cuccaggccg gga                         43


<210>  35
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  35
ucucggaauc gggguucgaa aucgaacucg cuccacgccg gga                         43


<210>  36
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  36
ucucggaauc gggguucgaa aucgaacucg cuccacgccg gga                         43


<210>  37
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  37
ucucggaauc gggguucgaa uccgaacucg cuccacgccg gga                         43


<210>  38
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  38
ucucggaauc gggcuucgaa accgaagucg cuccacgccg gga                         43


<210>  39
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  39
ucucggaauc gggguucaca accgaacucg cuccacgccg gga                         43


<210>  40
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  40
ucucggaauc gggguucgau acagaacucg cuccacgccg gga                         43


<210>  41
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  41
ucucggaauc gggguucgac accgaacucg cuccaggccg gga                         43


<210>  42
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  42
ucucggaauc gggcuucgca accgaagucg cuccaggccg gga                         43


<210>  43
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  43
ucucggaauc ggggcucgaa accgagcucg cuccaggccg gga                         43


<210>  44
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  44
ucucggaauc gggguuccaa agcgaacucg cuccaggccg gga                         43


<210>  45
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  45
ucucggaauc gggguuccua accgaacucg cuccaggccg gga                         43


<210>  46
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  46
ucucggaauc gggguuccua accgaacucg cuccaggccg gga                         43


<210>  47
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  47
ucucggaauc gggguuccua aucgaacucg cuccacgccg gga                         43


<210>  48
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  48
ucucggaauc gggguucuua accgaacucg cuccaagccg gga                         43


<210>  49
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  49
ucucggaauc gggguucgau agcgaacucg cuccaggccg gga                         43


<210>  50
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  50
ucucggaauc gggguucgga aacgaacucg cuccaggccg gga                         43


<210>  51
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  51
ucucggaauc gggguucgga agcgaacucg cuccaggccg gga                         43


<210>  52
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  52
ucucggaauc gggguucggg accgaacucg cuccaggccg gga                         43


<210>  53
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  53
ucucggaauc gggcuucgaa uccggagucg cuccacgccg gga                         43


<210>  54
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  54
ucucggaauc gggcuucgag accgaagucg cuccaggccg gga                         43


<210>  55
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  55
ucucggaauc gggguuccua acagaacucg cuccaggccg gga                         43


<210>  56
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  56
ucucggaauc gggguucaac acugaacucg cuccaggccg gga                         43


<210>  57
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  57
ucucggaauc gggguucgau gcugaacucg cuccaggccg gga                         43


<210>  58
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  58
ucucggaauc gggguucgug acugaacucg cuccaggccg gga                         43


<210>  59
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  59
ucucggaauc gggguucgug cccgaacucg cuccaggccg gga                         43


<210>  60
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n= A, U, G, or C

<400>  60
ucucggaauc gggguuggga acncaacucg cuccacgccg gga                         43


<210>  61
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  61
ucucggaauc gggguuugga aacgaacucg cuccaggccg gga                         43


<210>  62
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  62
ucucggaauc gggguucaaa aucgaagucg cuccaggccg gga                         43


<210>  63
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  63
ucucggaauc gggcuucgaa ngcgaagucg cuccaggccg gga                         43


<210>  64
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  64
ucucggaauc gggcuucgua uccgaagucg cuccaggccg gga                         43


<210>  65
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  65
ucucggaauc gggguacuca aucgaacucg cuccaggccg gga                         43


<210>  66
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  66
ucucggaauc gggguccaaa uccggacucg cuccaggccg gga                         43


<210>  67
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  67
ucucggaauc ggggucccua accggacucg cuccaggccg gga                         43


<210>  68
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  68
ucucggaauc gggguccuua gccggacucg cuccacgccg gga                         43


<210>  69
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  69
ucucggaauc gggguucaau ggcgaacucg cuccaggccg gga                         43


<210>  70
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  70
ucucggaauc gggguuccag agagaacucg cuccaggccg gga                         43


<210>  71
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  71
ucucggaauc gggguuccau gacgaacucg cuccaggccg gga                         43


<210>  72
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  72
ucucggaauc gggauucgua aucggauucg cuccaggccg gga                         43


<210>  73
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  73
ucucggaauc gggcuucguu uccgaagucg cuccaggccg gga                         43


<210>  74
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  74
ucucggaauc gggguaccuu accguacucg cuccaggccg gga                         43


<210>  75
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  75
ucucggaauc ggggugcuua acugcacucg cuccaggccg gga                         43


<210>  76
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  76
ucucggaauc gggguuccaa ugagcacucg cuccaggccg gga                         43


<210>  77
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  77
ucucggaauc gggguuccgc gcggaacucg cuccaggccg gga                         43


<210>  78
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  78
ucucggaauc gggguuccuc ucggaacucg cuccaggccg gga                         43


<210>  79
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  79
ucucggaauc gggguucggg nucggacucg cuccaggccg gga                         43


<210>  80
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  80
ucucggaauc gggcuucaga aaugaagucg cuccaggccg gga                         43


<210>  81
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  81
ucucggaauc gggcuucagu uccgaagucg cuccaggccg gga                         43


<210>  82
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  82
ucucggaauc gggcuucgcu ugcgaagucg cuccaggccg gga                         43


<210>  83
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  83
ucucggaauc gggguccaua aacggacucg cuccacccug gga                         43


<210>  84
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  84
ucucggaauc gggccucgac auugaggucg cuccaggccg gga                         43


<210>  85
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  85
ucucggaauc gggcucccua aacggagucg cuccaggccg gga                         43


<210>  86
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  86
ucucggaauc gggguaccug gcgguacucg cuccaggccg gga                         43


<210>  87
<211>  44
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(44)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  87
ucucggaagc ggggguggga ccccaacucu cuccccgccg ggga                        44


<210>  88
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  88
ucucggaauc gggguuccug gcgcagcucg cucccccccg gga                         43


<210>  89
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  89
ucucggaauc ggcuuucuaa cucuuacucu uuccucgccg gga                         43


<210>  90
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  90
ucucggagcc ccgguacaaa accguguucg cuccaggccg gga                         43


<210>  91
<211>  44
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(44)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  91
ucucggagug ggggguggaa ucccagcucg cucccccccg ggga                        44


<210>  92
<211>  42
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  92
ucucugaucg gggauccuag cccaagucgc gcccccccgg ga                          42


<210>  93
<211>  42
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  93
ucucugaucg cgguaccaaa cgcaacacgc gccgccccgg ga                          42


<210>  94
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  94
ucucggauuc gcgguuccaa gcccgucucc ccucacgcgc gga                         43


<210>  95
<211>  42
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  95
ucucagaccg cggaaagaca ucgagcacgg accacgccgg ga                          42


<210>  96
<211>  42
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  96
ucuccaaucu uucuuacaaa ccguacucuc uucaugaccg ga                          42


<210>  97
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  97
ucucggaagc aaacuucccc uccgaacacu cuccucaccg gga                         43


<210>  98
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  98
ucucggaauc ccugauccau acccaggucc ccccuccccg gga                         43


<210>  99
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  99
ucucggucuc ggcgugugcu cccgaacugc cucuacaccc gga                         43


<210>  100
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  100
ucucggugcc ccgguucaag accgugcucg cgccaaucag gga                         43


<210>  101
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  101
ucucguaacc gugccucuac ucccaccucc cuccaugacg gga                         43


<210>  102
<211>  42
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  102
ucucugaucg cgcuuggcaa ccgaagucau gucgccccgg ga                          42


<210>  103
<211>  42
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  103
ucucugaucg ggucucacag ccgauccggc ugccccccgg ga                          42


<210>  104
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  104
ucucggaagu ggcguaucga cccuaaucag cuccuccccg gga                         43


<210>  105
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  105
gggagaucuc ggaaucgggg uucgaaaccg aacucgcucc acgccggga                   49


<210>  106
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  106
gggagaucuc ggaaucgggg uccaaauccg gacucgcucc aggccggga                   49


<210>  107
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  107
gggagaucuc ggaaucgggg uucgugcccg aacucgcucc aggccggga                   49


<210>  108
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  108
gggagaucuc ggaaucgggg uucggaaacg aacucgcucc aggccggga                   49


<210>  109
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  109
gggagaucuc ggaaucgggc uucgaaaccg aagucgcucc acgccggga                   49


<210>  110
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  110
gggagaucuc ggaaucgggg uucgaaaccg aacucgcucc aggccggga                   49


<210>  111
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  111
gggagaucuc ggaaucgggg uucgaaaccg aacucgcucc acgccgggau cuccc            55


<210>  112
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  112
gggagaucuc ggaaucgggg uucggaaacg aacucgcucc aggccgggau cuccc            55


<210>  113
<211>  53
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(53)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  113
gggagauccg gaaucggggu ucggaaacga acucgcucca ggccggaucu ccc              53


<210>  114
<211>  51
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(51)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  114
gggagaucgg aaucgggguu cggaaacgaa cucgcuccag gccgaucucc c                51


<210>  115
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  115
gggagaugga aucgggguuc ggaaacgaac ucgcuccagg ccaucuccc                   49


<210>  116
<211>  47
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  116
gggagaggaa ucgggguucg gaaacgaacu cgcuccaggc cucuccc                     47


<210>  117
<211>  45
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(45)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  117
gggagagaau cgggguucgg aaacgaacuc gcuccaggcu cuccc                       45


<210>  118
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  118
gggaggaauc gggguucgga aacgaacucg cuccaggccu ccc                         43


<210>  119
<211>  53
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(53)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  119
gggagaucuc ggaaucgggu ucggaaacga acugcuccag gccgggaucu ccc              53


<210>  120
<211>  53
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(53)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  120
gggagaucuc ggaaucgggu ucggaaacga accgcuccag gccgggaucu ccc              53


<210>  121
<211>  53
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  121
gggagaucuc ggaaucgggu ucggaaacga aucgcuccag gccgggaucu ccc              53


<210>  122
<211>  53
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(53)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  122
gggagaucuc ggaaucgggg ucggaaacga cucgcuccag gccgggaucu ccc              53


<210>  123
<211>  53
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(53)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  123
gggagaucuc ggaaucgggg uuggaaacaa cucgcuccag gccgggaucu ccc              53


<210>  124
<211>  53
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(53)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  124
gggagaucuc ggaaucgggg uucgaaagaa cucgcuccag gccgggaucu ccc              53


<210>  125
<211>  51
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(51)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  125
gggagaucuc ggaaucgggu cggaaacgau cgcuccaggc cgggaucucc c                51


<210>  126
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  126
gggagaucuc ggaaucgggu cgaaagaucg cuccaggccg ggaucuccc                   49


<210>  127
<211>  42
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  127
gggagaggaa ucgggucgga aacgucgcuc caggccucuc cc                          42


<210>  128
<211>  41
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(41)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  128
gggagaggaa ucgggucgaa agaucgcucc aggccucucc c                           41


<210>  129
<211>  41
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(41)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  129
gggagaggaa ucgcgucgaa agauggcucc aggccucucc c                           41


<210>  130
<211>  41
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(41)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  130
gggagagaau cgggucggaa acgaucgcuc caggcucucc c                           41


<210>  131
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  131
gggagaucuc ggaaucgggu ggaaacaucg cuccaggccg ggaucuccc                   49


<210>  132
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  132
gggagaucuc ggaaucgggc ggaaacgucg cuccaggccg ggaucuccc                   49


<210>  133
<211>  51
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(51)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  133
gggagaucuc ggaaucgggu ccgaaaggau cgcuccaggc cgggaucucc c                51


<210>  134
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  134
gggagauccg gaaucggguc ggaaacgauc gcuccaggcc ggaucuccc                   49


<210>  135
<211>  47
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  135
gggagaucgg aaucgggucg gaaacgaucg cuccaggccg aucuccc                     47


<210>  136
<211>  45
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(45)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  136
gggagaugga aucgggucgg aaacgaucgc uccaggccau cuccc                       45


<210>  137
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  137
gggagaucuc gguuucgggg uucgaaaccg aacucgcucc acgccggga                   49


<210>  138
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  138
gggagaucuc ggaaaggggg uucgaaaccg aacucgcucc acgccggga                   49


<210>  139
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  139
gggagaucuc ggaaucgggg uucguuaccg aacucgcucc acgccggga                   49


<210>  140
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  140
gggagaucuc ggaaucgggg uucgaaugcg aacucgcucc acgccggga                   49


<210>  141
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  141
gggagaucuc ggaaucgggg uucgaaaccg aacuccgucc acgccggga                   49


<210>  142
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  142
gggagaucuc ggaaucgggg uucgaaaccg aacucgcagc acgccggga                   49


<210>  143
<211>  49
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(49)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  143
gggagaucuc ggaaucgggg uucgaaaccg aacucgcucg ucgccggga                   49


<210>  144
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  144
gggagaucuc ggaaucgggg uucgaaaccg aacuccgucc acgccgggau cuccc            55


<210>  145
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  145
gggagaucuc ggaaucgggg uucgaaaccg aacucgcagc acgccgggau cuccc            55


<210>  146
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  146
gggagaucuc ggaaucgggg uucggaaacg aacuccgucc aggccgggau cuccc            55


<210>  147
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  147
gggagaucuc ggaaucgggg uucggaaacg aacucgcagc aggccgggau cuccc            55


<210>  148
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  148
gggagaucuc ggaaucgggg uugggaaacc aacucgcucc aggccgggau cuccc            55


<210>  149
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  149
gggagaucuc ggaaucgggg uuaggaaacu aacucgcucc aggccgggau cuccc            55


<210>  150
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  150
gggagaucuc ggaaucgggg uucggaaacg aacccgcucc aggccgggau cuccc            55


<210>  151
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  151
gggagaucuc ggaaucggag uucggaaacg aacucgcucc aggccgggau cuccc            55


<210>  152
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  152
gggagaucuc ggaaucgcgg uucggaaacg aacuggcucc aggccgggau cuccc            55


<210>  153
<211>  55
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  153
gggagaucuc ggaaucggug uucggaaacg aacgcgcucc aggccgggau cuccc            55


<210>  154
<211>  47
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  154
gggagaucgg aaucgcuucg gaaacgaggg cuccaggccg aucuccc                     47


<210>  155
<211>  46
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(46)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  155
gggagaucgg aaucgggucg gaaacgaucg cuccagccga ucuccc                      46


<210>  156
<211>  46
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(46)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  156
gggagaucgg aaucgggucg gaaacgaucg cuccggccga ucuccc                      46


<210>  157
<211>  46
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(46)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<400>  157
gggagaucgg aaucgggucg gaaacgaucc uccaggccga ucuccc                      46


<210>  158
<211>  12
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  158
gggagaucuc gg                                                           12


<210>  159
<211>  12
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  159
ccgggaucuc cc                                                           12


<210>  160
<211>  10
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  160
gggagaucgg                                                              10


<210>  161
<211>  10
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  161
ccgaucuccc                                                              10


<210>  162
<211>  48
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Inverted Deoxythymidine

<400>  162
gggagaucgg aaucgggucg gaaacgaucg cuccaggccg aucucccn                    48


<210>  163
<211>  45
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(45)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotideser

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  inverted deoxythymidine

<400>  163
gggagaucgg aaucgggucg ncgaucgcuc caggccgauc ucccn                       45


<210>  164
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  6GLY) hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  inverted deoxythymidine

<400>  164
ggagaucgga aucgggucgn cgaucgcucc aggccgaucu ccn                         43


<210>  165
<211>  41
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(41)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  inverted deoxythymidine

<400>  165
gagaucggaa ucgggucgnc gaucgcucca ggccgaucuc n                           41


<210>  166
<211>  39
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(39)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  inverted deoxythymidine

<400>  166
agaucggaau cgggucgncg aucgcuccag gccgaucun                              39


<210>  167
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  167
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  168
<211>  43
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  inverted deoxythymidine

<400>  168
gggagaucga aucgggucgn cgaucgcucc aggcgaucuc ccn                         43


<210>  169
<211>  41
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(41)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  inverted deoxythymidine

<400>  169
gggagaugaa ucgggucgnc gaucgcucca ggcaucuccc n                           41


<210>  170
<211>  39
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(39)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  inverted deoxythymidine

<400>  170
gggagagaau cgggucgncg aucgcuccag gcucucccn                              39


<210>  171
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  171
gggagaaauc gggucgncga ucgcuccagg ucucccn                                37


<210>  172
<211>  35
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  inverted deoxythymidine

<400>  172
gaucgaaucg ggucgncgau cgcuccaggc gaucn                                  35


<210>  173
<211>  33
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(33)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  inverted deoxythymidine

<400>  173
gaugaaucgg gucgncgauc gcuccaggca ucn                                    33


<210>  174
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  174
agaucgaauc gggucgncga ucgcuccagg cgaucun                                37


<210>  175
<211>  35
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  inverted deoxythymidine

<400>  175
agaugaaucg ggucgncgau cgcuccaggc aucun                                  35


<210>  176
<211>  35
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  inverted deoxythymidine

<400>  176
gaucggaauc gggcgncguc gcuccaggcc gaucn                                  35


<210>  177
<211>  35
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  inverted deoxythymidine

<400>  177
gaucggaauc gggugncauc gcuccaggcc gaucn                                  35


<210>  178
<211>  35
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  inverted deoxythymidine

<400>  178
gaucggaauc gggucngauc gcuccaggcc gaucn                                  35


<210>  179
<211>  37
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  179
gaucggaauc gggucgncga ucgcagcagg ccgaucn                                37


<210>  180
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (3)..(16)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (18)..(34)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  180
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  181
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (5)..(16)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (18)..(32)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  181
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  182
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (7)..(16)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (18)..(30)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (33)..(36)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  182
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  183
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (7)..(16)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (18)..(30)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is a, c, g, or u

<400>  183
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  184
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (7)..(11)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (23)..(30)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  184
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  185
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (22)..(30)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  185
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  186
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (21)..(30)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  186
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  187
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (7)..(14)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (20)..(30)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  187
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  188
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (7)..(15)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (19)..(30)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  188
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  189
<211>  37
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (7)..(14)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  6GLY hexaethylene glycol linker

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (20)..(30)
<223>  All Pyrimidines (Cytosine and Uracil) are 2'-fluoro nucleotides; 
       All Purines (Alanine and Guanine) are 2'-hydroxyl nucleotides

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  2'-O-methyl nucleotides

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  inverted deoxythymidine

<400>  189
gaucggaauc gggucgncga ucgcuccagg ccgaucn                                37


<210>  190
<211>  14
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  All nucleotides are 2'-O-methyl nucleotides

<400>  190
uuuccgaccc gauu                                                         14


<210>  191
<211>  17
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  All nucleotides are 2'-O-methyl nucleotides

<400>  191
ccuggagcga ucguuuc                                                      17


<210>  192
<211>  17
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  All nucleotides are 2'-O-methyl nucleotides

<400>  192
ggagaucggc cuggagc                                                      17


<210>  193
<211>  13
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  All nucleotides are 2'-O-methyl nucleotides

<400>  193
ccuggagcga ucg                                                          13


<210>  194
<211>  15
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  All nucleotides are 2'-O-methyl nucleotides

<400>  194
cgauuccgau cuccc                                                        15


