                         SEQUENCE LISTING

<110>  MDxHealth SA
       Meijer, Gerrit A
       Carvalho, Beatriz A
       Bosch, Linda JW
       van Criekinge, Wim
       Trooskens, Geert
 
<120>  METHYLATION MARKERS PREDICTIVE FOR DRUG RESPONSE

<130>  5545-00019

<150>  US 61/718,502
<151>  2012-10-25

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1432
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gln Gln Arg Lys Cys Pro 
1               5                   10                  15      


Glu Trp Met Asn Val Gln Asn Lys Arg Cys Ala Val Glu Glu Arg Lys 
            20                  25                  30          


Ala Cys Val Arg Lys Ser Val Phe Glu Asp Asp Leu Pro Phe Leu Glu 
        35                  40                  45              


Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Ala Ser Asp Cys Ser Phe 
    50                  55                  60                  


Leu Ser Glu Asp Ile Ser Met Ser Leu Ser Asp Gly Asp Val Val Gly 
65                  70                  75                  80  


Phe Asp Met Glu Trp Pro Pro Leu Tyr Asn Arg Gly Lys Leu Gly Lys 
                85                  90                  95      


Val Ala Leu Ile Gln Leu Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe 
            100                 105                 110         


His Val Ser Ser Met Ser Val Phe Pro Gln Gly Leu Lys Met Leu Leu 
        115                 120                 125             


Glu Asn Lys Ala Val Lys Lys Ala Gly Val Gly Ile Glu Gly Asp Gln 
    130                 135                 140                 


Trp Lys Leu Leu Arg Asp Phe Asp Ile Lys Leu Lys Asn Phe Val Glu 
145                 150                 155                 160 


Leu Thr Asp Val Ala Asn Lys Lys Leu Lys Cys Thr Glu Thr Trp Ser 
                165                 170                 175     


Leu Asn Ser Leu Val Lys His Leu Leu Gly Lys Gln Leu Leu Lys Asp 
            180                 185                 190         


Lys Ser Ile Arg Cys Ser Asn Trp Ser Lys Phe Pro Leu Thr Glu Asp 
        195                 200                 205             


Gln Lys Leu Tyr Ala Ala Thr Asp Ala Tyr Ala Gly Phe Ile Ile Tyr 
    210                 215                 220                 


Arg Asn Leu Glu Ile Leu Asp Asp Thr Val Gln Arg Phe Ala Ile Asn 
225                 230                 235                 240 


Lys Glu Glu Glu Ile Leu Leu Ser Asp Met Asn Lys Gln Leu Thr Ser 
                245                 250                 255     


Ile Ser Glu Glu Val Met Asp Leu Ala Lys His Leu Pro His Ala Phe 
            260                 265                 270         


Ser Lys Leu Glu Asn Pro Arg Arg Val Ser Ile Leu Leu Lys Asp Ile 
        275                 280                 285             


Ser Glu Asn Leu Tyr Ser Leu Arg Arg Met Ile Ile Gly Ser Thr Asn 
    290                 295                 300                 


Ile Glu Thr Glu Leu Arg Pro Ser Asn Asn Leu Asn Leu Leu Ser Phe 
305                 310                 315                 320 


Glu Asp Ser Thr Thr Gly Gly Val Gln Gln Lys Gln Ile Arg Glu His 
                325                 330                 335     


Glu Val Leu Ile His Val Glu Asp Glu Thr Trp Asp Pro Thr Leu Asp 
            340                 345                 350         


His Leu Ala Lys His Asp Gly Glu Asp Val Leu Gly Asn Lys Val Glu 
        355                 360                 365             


Arg Lys Glu Asp Gly Phe Glu Asp Gly Val Glu Asp Asn Lys Leu Lys 
    370                 375                 380                 


Glu Asn Met Glu Arg Ala Cys Leu Met Ser Leu Asp Ile Thr Glu His 
385                 390                 395                 400 


Glu Leu Gln Ile Leu Glu Gln Gln Ser Gln Glu Glu Tyr Leu Ser Asp 
                405                 410                 415     


Ile Ala Tyr Lys Ser Thr Glu His Leu Ser Pro Asn Asp Asn Glu Asn 
            420                 425                 430         


Asp Thr Ser Tyr Val Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met 
        435                 440                 445             


Leu Lys His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val 
    450                 455                 460                 


Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys Ser Leu Glu 
465                 470                 475                 480 


Asn Leu Asn Ser Gly Thr Val Glu Pro Thr His Ser Lys Cys Leu Lys 
                485                 490                 495     


Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Glu Glu Asp Asp 
            500                 505                 510         


Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Lys Asp Phe Leu 
        515                 520                 525             


Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Lys Met Tyr Phe 
    530                 535                 540                 


Gly His Ser Ser Phe Lys Pro Val Gln Trp Lys Val Ile His Ser Val 
545                 550                 555                 560 


Leu Glu Glu Arg Arg Asp Asn Val Ala Val Met Ala Thr Gly Tyr Gly 
                565                 570                 575     


Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gly Lys Ile Gly 
            580                 585                 590         


Leu Val Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gln Val Leu Gln 
        595                 600                 605             


Leu Lys Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Ser Ala Gln Ser 
    610                 615                 620                 


Glu Asn Val Leu Thr Asp Ile Lys Leu Gly Lys Tyr Arg Ile Val Tyr 
625                 630                 635                 640 


Val Thr Pro Glu Tyr Cys Ser Gly Asn Met Gly Leu Leu Gln Gln Leu 
                645                 650                 655     


Glu Ala Asp Ile Gly Ile Thr Leu Ile Ala Val Asp Glu Ala His Cys 
            660                 665                 670         


Ile Ser Glu Trp Gly His Asp Phe Arg Asp Ser Phe Arg Lys Leu Gly 
        675                 680                 685             


Ser Leu Lys Thr Ala Leu Pro Met Val Pro Ile Val Ala Leu Thr Ala 
    690                 695                 700                 


Thr Ala Ser Ser Ser Ile Arg Glu Asp Ile Val Arg Cys Leu Asn Leu 
705                 710                 715                 720 


Arg Asn Pro Gln Ile Thr Cys Thr Gly Phe Asp Arg Pro Asn Leu Tyr 
                725                 730                 735     


Leu Glu Val Arg Arg Lys Thr Gly Asn Ile Leu Gln Asp Leu Gln Pro 
            740                 745                 750         


Phe Leu Val Lys Thr Ser Ser His Trp Glu Phe Glu Gly Pro Thr Ile 
        755                 760                 765             


Ile Tyr Cys Pro Ser Arg Lys Met Thr Gln Gln Val Thr Gly Glu Leu 
    770                 775                 780                 


Arg Lys Leu Asn Leu Ser Cys Gly Thr Tyr His Ala Gly Met Ser Phe 
785                 790                 795                 800 


Ser Thr Arg Lys Asp Ile His His Arg Phe Val Arg Asp Glu Ile Gln 
                805                 810                 815     


Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gly Ile Asn Lys Ala Asp 
            820                 825                 830         


Ile Arg Gln Val Ile His Tyr Gly Ala Pro Lys Asp Met Glu Ser Tyr 
        835                 840                 845             


Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Ser Ser Cys 
    850                 855                 860                 


His Val Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn Arg His Leu Leu 
865                 870                 875                 880 


Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Leu Lys Met Met 
                885                 890                 895     


Ala Lys Met Glu Lys Tyr Leu His Ser Ser Arg Cys Arg Arg Gln Ile 
            900                 905                 910         


Ile Leu Ser His Phe Glu Asp Lys Gln Val Gln Lys Ala Ser Leu Gly 
        915                 920                 925             


Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Ser Arg Leu Asp 
    930                 935                 940                 


His Cys Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Trp Asp Phe Gly 
945                 950                 955                 960 


Pro Gln Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Leu Gly Glu Lys 
                965                 970                 975     


Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Ser Asn Ser Gln 
            980                 985                 990         


Arg Leu Ala Asp Gln Tyr Arg Arg  His Ser Leu Phe Gly  Thr Gly Lys 
        995                 1000                 1005             


Asp Gln  Thr Glu Ser Trp Trp  Lys Ala Phe Ser Arg  Gln Leu Ile 
    1010                 1015                 1020             


Thr Glu  Gly Phe Leu Val Glu  Val Ser Arg Tyr Asn  Lys Phe Met 
    1025                 1030                 1035             


Lys Ile  Cys Ala Leu Thr Lys  Lys Gly Arg Asn Trp  Leu His Lys 
    1040                 1045                 1050             


Ala Asn  Thr Glu Ser Gln Ser  Leu Ile Leu Gln Ala  Asn Glu Glu 
    1055                 1060                 1065             


Leu Cys  Pro Lys Lys Leu Leu  Leu Pro Ser Ser Lys  Thr Val Ser 
    1070                 1075                 1080             


Ser Gly  Thr Lys Glu His Cys  Tyr Asn Gln Val Pro  Val Glu Leu 
    1085                 1090                 1095             


Ser Thr  Glu Lys Lys Ser Asn  Leu Glu Lys Leu Tyr  Ser Tyr Lys 
    1100                 1105                 1110             


Pro Cys  Asp Lys Ile Ser Ser  Gly Ser Asn Ile Ser  Lys Lys Ser 
    1115                 1120                 1125             


Ile Met  Val Gln Ser Pro Glu  Lys Ala Tyr Ser Ser  Ser Gln Pro 
    1130                 1135                 1140             


Val Ile  Ser Ala Gln Glu Gln  Glu Thr Gln Ile Val  Leu Tyr Gly 
    1145                 1150                 1155             


Lys Leu  Val Glu Ala Arg Gln  Lys His Ala Asn Lys  Met Asp Val 
    1160                 1165                 1170             


Pro Pro  Ala Ile Leu Ala Thr  Asn Lys Ile Leu Val  Asp Met Ala 
    1175                 1180                 1185             


Lys Met  Arg Pro Thr Thr Val  Glu Asn Val Lys Arg  Ile Asp Gly 
    1190                 1195                 1200             


Val Ser  Glu Gly Lys Ala Ala  Met Leu Ala Pro Leu  Leu Glu Val 
    1205                 1210                 1215             


Ile Lys  His Phe Cys Gln Thr  Asn Ser Val Gln Thr  Asp Leu Phe 
    1220                 1225                 1230             


Ser Ser  Thr Lys Pro Gln Glu  Glu Gln Lys Thr Ser  Leu Val Ala 
    1235                 1240                 1245             


Lys Asn  Lys Ile Cys Thr Leu  Ser Gln Ser Met Ala  Ile Thr Tyr 
    1250                 1255                 1260             


Ser Leu  Phe Gln Glu Lys Lys  Met Pro Leu Lys Ser  Ile Ala Glu 
    1265                 1270                 1275             


Ser Arg  Ile Leu Pro Leu Met  Thr Ile Gly Met His  Leu Ser Gln 
    1280                 1285                 1290             


Ala Val  Lys Ala Gly Cys Pro  Leu Asp Leu Glu Arg  Ala Gly Leu 
    1295                 1300                 1305             


Thr Pro  Glu Val Gln Lys Ile  Ile Ala Asp Val Ile  Arg Asn Pro 
    1310                 1315                 1320             


Pro Val  Asn Ser Asp Met Ser  Lys Ile Ser Leu Ile  Arg Met Leu 
    1325                 1330                 1335             


Val Pro  Glu Asn Ile Asp Thr  Tyr Leu Ile His Met  Ala Ile Glu 
    1340                 1345                 1350             


Ile Leu  Lys His Gly Pro Asp  Ser Gly Leu Gln Pro  Ser Cys Asp 
    1355                 1360                 1365             


Val Asn  Lys Arg Arg Cys Phe  Pro Gly Ser Glu Glu  Ile Cys Ser 
    1370                 1375                 1380             


Ser Ser  Lys Arg Ser Lys Glu  Glu Val Gly Ile Asn  Thr Glu Thr 
    1385                 1390                 1395             


Ser Ser  Ala Glu Arg Lys Arg  Arg Leu Pro Val Trp  Phe Ala Lys 
    1400                 1405                 1410             


Gly Ser  Asp Thr Ser Lys Lys  Leu Met Asp Lys Thr  Lys Arg Gly 
    1415                 1420                 1425             


Gly Leu  Phe Ser 
    1430         


<210>  2
<211>  5765
<212>  DNA
<213>  Homo sapiens

<400>  2
cagccgcccc tcctgcggcc gctgcggggg ccgccgcctg acttcggaca ccggccccgc       60

acccgccagg aggggaggga aggggaggcg gggagagcga cggcgggggg cgggcggtgg      120

accccgcctc ccccggcaca gcctgctgag gggaagaggg ggtctccgct cttcctcagt      180

gcactctctg actgaagccc ggcgcgtggg gtgcagcggg agtgcgaggg gactggacag      240

gtgggaagat gggaatgagg accgggcggc gggaatgttc tcacttctcc ggattccacc      300

gggatgcagg actctagctg cccagccgca cctgcgaaga gactacactt cccgaggtgc      360

tcagcggcag cgagggcctc cacgcatgcg caccgcggcg cgctgggcgg ggctggatgg      420

gctgtggtgg gagggttgca gcgccgcgag aaaggcgagc cgggccgggg gcggggaaag      480

gggtggggca ggaacggggg cggggacggc gctggagggg cgggtcgggt aggtctcccg      540

gagctgatgt gtactgtgtg cgccggggag gcgccggctt gtactcggca gcgcgggaat      600

aaagtttgct gatttggtgt ctagcctgga tgcctgggtt gcaggccctg cttgtggtgg      660

cgctccacag tcatccggct gaagaagacc tgttggactg gatcttctcg ggttttcttt      720

cagatattgt tttgtattta cccatgaaga cattgttttt tggactctgc aaataggaca      780

tttcaaagat gagtgaaaaa aaattggaaa caactgcaca gcagcggaaa tgtcctgaat      840

ggatgaatgt gcagaataaa agatgtgctg tagaagaaag aaaggcatgt gttcggaaga      900

gtgtttttga agatgacctc cccttcttag aattcactgg atccattgtg tatagttacg      960

atgctagtga ttgctctttc ctgtcagaag atattagcat gagtctatca gatggggatg     1020

tggtgggatt tgacatggag tggccaccat tatacaatag agggaaactt ggcaaagttg     1080

cactaattca gttgtgtgtt tctgagagca aatgttactt gttccacgtt tcttccatgt     1140

cagtttttcc ccagggatta aaaatgttgc ttgaaaataa agcagttaaa aaggcaggtg     1200

taggaattga aggagatcag tggaaacttc tacgtgactt tgatatcaaa ttgaagaatt     1260

ttgtggagtt gacagatgtt gccaataaaa agctgaaatg cacagagacc tggagcctta     1320

acagtctggt taaacacctc ttaggtaaac agctcctgaa agacaagtct atccgctgta     1380

gcaattggag taaatttcct ctcactgagg accagaaact gtatgcagcc actgatgctt     1440

atgctggttt tattatttac cgaaatttag agattttgga tgatactgtg caaaggtttg     1500

ctataaataa agaggaagaa atcctactta gcgacatgaa caaacagttg acttcaatct     1560

ctgaggaagt gatggatctg gctaagcatc ttcctcatgc tttcagtaaa ttggaaaacc     1620

cacggagggt ttctatctta ctaaaggata tttcagaaaa tctatattca ctgaggagga     1680

tgataattgg gtctactaac attgagactg aactgaggcc cagcaataat ttaaacttat     1740

tatcctttga agattcaact actgggggag tacaacagaa acaaattaga gaacatgaag     1800

ttttaattca cgttgaagat gaaacatggg acccaacact tgatcattta gctaaacatg     1860

atggagaaga tgtacttgga aataaagtgg aacgaaaaga agatggattt gaagatggag     1920

tagaagacaa caaattgaaa gagaatatgg aaagagcttg tttgatgtcg ttagatatta     1980

cagaacatga actccaaatt ttggaacagc agtctcagga agaatatctt agtgatattg     2040

cttataaatc tactgagcat ttatctccca atgataatga aaacgatacg tcctatgtaa     2100

ttgagagtga tgaagattta gaaatggaga tgcttaagca tttatctccc aatgataatg     2160

aaaacgatac gtcctatgta attgagagtg atgaagattt agaaatggag atgcttaagt     2220

ctttagaaaa cctcaatagt ggcacggtag aaccaactca ttctaaatgc ttaaaaatgg     2280

aaagaaatct gggtcttcct actaaagaag aagaagaaga tgatgaaaat gaagctaatg     2340

aaggggaaga agatgatgat aaggactttt tgtggccagc acccaatgaa gagcaagtta     2400

cttgcctcaa gatgtacttt ggccattcca gttttaaacc agttcagtgg aaagtgattc     2460

attcagtatt agaagaaaga agagataatg ttgctgtcat ggcaactgga tatggaaaga     2520

gtttgtgctt ccagtatcca cctgtttatg taggcaagat tggccttgtt atctctcccc     2580

ttatttctct gatggaagac caagtgctac agcttaaaat gtccaacatc ccagcttgct     2640

tccttggatc agcacagtca gaaaatgttc taacagatat taaattaggt aaataccgga     2700

ttgtatacgt aactccagaa tactgttcag gtaacatggg cctgctccag caacttgagg     2760

ctgatattgg tatcacgctc attgctgtgg atgaggctca ctgtatttct gagtgggggc     2820

atgattttag ggattcattc aggaagttgg gctccctaaa gacagcactg ccaatggttc     2880

caatcgttgc acttactgct actgcaagtt cttcaatccg ggaagacatt gtacgttgct     2940

taaatctgag aaatcctcag atcacctgta ctggttttga tcgaccaaac ctgtatttag     3000

aagttaggcg aaaaacaggg aatatccttc aggatctgca gccatttctt gtcaaaacaa     3060

gttcccactg ggaatttgaa ggtccaacaa tcatctactg tccttctaga aaaatgacac     3120

aacaagttac aggtgaactt aggaaactga atctatcctg tggaacatac catgcgggca     3180

tgagttttag cacaaggaaa gacattcatc ataggtttgt aagagatgaa attcagtgtg     3240

tcatagctac catagctttt ggaatgggca ttaataaagc tgacattcgc caagtcattc     3300

attacggtgc tcctaaggac atggaatcat attatcagga gattggtaga gctggtcgtg     3360

atggacttca aagttcttgt cacgtcctct gggctcctgc agacattaac ttaaataggc     3420

accttcttac tgagatacgt aatgagaagt ttcgattata caaattaaag atgatggcaa     3480

agatggaaaa atatcttcat tctagcagat gtaggagaca aatcatcttg tctcattttg     3540

aggacaaaca agtacaaaaa gcctccttgg gaattatggg aactgaaaaa tgctgtgata     3600

attgcaggtc cagattggat cattgctatt ccatggatga ctcagaggat acatcctggg     3660

actttggtcc acaagcattt aagcttttgt ctgctgtgga catcttaggc gaaaaatttg     3720

gaattgggct tccaatttta tttctccgag gatctaattc tcagcgtctt gccgatcaat     3780

atcgcaggca cagtttattt ggcactggca aggatcaaac agagagttgg tggaaggctt     3840

tttcccgtca gctgatcact gagggattct tggtagaagt ttctcggtat aacaaattta     3900

tgaagatttg cgcccttacg aaaaagggta gaaattggct tcataaagct aatacagaat     3960

ctcagagcct catccttcaa gctaatgaag aattgtgtcc aaagaagttg cttctgccta     4020

gttcgaaaac tgtatcttcg ggcaccaaag agcattgtta taatcaagta ccagttgaat     4080

taagtacaga gaagaagtct aacttggaga agttatattc ttataaacca tgtgataaga     4140

tttcttctgg gagtaacatt tctaaaaaaa gtatcatggt acagtcacca gaaaaagctt     4200

acagttcctc acagcctgtt atttcggcac aagagcagga gactcagatt gtgttatatg     4260

gcaaattggt agaagctagg cagaaacatg ccaataaaat ggatgttccc ccagctattc     4320

tggcaacaaa caagatactg gtggatatgg ccaaaatgag accaactacg gttgaaaacg     4380

taaaaaggat tgatggtgtt tctgaaggca aagctgccat gttggcccct ctgttggaag     4440

tcatcaaaca tttctgccaa acaaatagtg ttcagacaga cctcttttca agtacaaaac     4500

ctcaagaaga acagaagacg agtctggtag caaaaaataa aatatgcaca ctttcacagt     4560

ctatggccat cacatactct ttattccaag aaaagaagat gcctttgaag agcatagctg     4620

agagcaggat tctgcctctc atgacaattg gcatgcactt atcccaagcg gtgaaagctg     4680

gctgccccct tgatttggag cgagcaggcc tgactccaga ggttcagaag attattgctg     4740

atgttatccg aaaccctccc gtcaactcag atatgagtaa aattagccta atcagaatgt     4800

tagttcctga aaacattgac acgtacctta tccacatggc aattgagatc cttaaacatg     4860

gtcctgacag cggacttcaa ccttcatgtg atgtcaacaa aaggagatgt tttcccggtt     4920

ctgaagagat ctgttcaagt tctaagagaa gcaaggaaga agtaggcatc aatactgaga     4980

cttcatctgc agagagaaag agacgattac ctgtgtggtt tgccaaagga agtgatacca     5040

gcaagaaatt aatggacaaa acgaaaaggg gaggtctttt tagttaagct ggcaattacc     5100

agaacaatta tgtttcttgc tgtattataa gaggatagct atattttatt tctgaagagt     5160

aaggagtagt attttggctt aaaaatcatt ctaattacaa agttcactgt ttattgaaga     5220

actggcatct taaatcagcc ttccgcaatt catgtagttt ctgggtcttc tgggagccta     5280

cgtgagtaca tcacctaaca gaatattaaa ttagacttcc tgtaagattg ctttaagaaa     5340

ctgttactgt cctgttttct aatctcttta ttaaaacagt gtatttggaa aatgttatgt     5400

gctctgattt gatatagata acagattagt agttacatgg taattatgtg atataaaata     5460

ttcatatatt atcaaaattc tgttttgtaa atgtaagaaa gcatagttat tttacaaatt     5520

gtttttactg tcttttgaag aagttcttaa atacgttgtt aaatggtatt agttgaccag     5580

ggcagtgaaa atgaaaccgc attttgggtg ccattaaata gggaaaaaac atgtaaaaaa     5640

tgtaaaatgg agaccaattg cactaggcaa gtgtatattt tgtattttat atacaatttc     5700

tattattttt caagtaataa aacaatgttt ttcatactga atattaaaaa aaaaaaaaaa     5760

aaaaa                                                                 5765


<210>  3
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Arg Ile Pro Lys Thr Leu Lys Phe Val Val Val Ile Val Ala 
1               5                   10                  15      


Val Leu Leu Pro Val Leu Ala Tyr Ser Ala Thr Thr Ala Arg Gln Glu 
            20                  25                  30          


Glu Val Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg His Ser Phe 
        35                  40                  45              


Lys Gly Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu His Thr Gly 
    50                  55                  60                  


Ala Cys Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Asn Ala Ser Asn 
65                  70                  75                  80  


Asn Glu Pro Ser Cys Phe Pro Cys Thr Val Cys Lys Ser Asp Gln Lys 
                85                  90                  95      


His Lys Ser Ser Cys Thr Met Thr Arg Asp Thr Val Cys Gln Cys Lys 
            100                 105                 110         


Glu Gly Thr Phe Arg Asn Glu Asn Ser Pro Glu Met Cys Arg Lys Cys 
        115                 120                 125             


Ser Arg Cys Pro Ser Gly Glu Val Gln Val Ser Asn Cys Thr Ser Trp 
    130                 135                 140                 


Asp Asp Ile Gln Cys Val Glu Glu Phe Gly Ala Asn Ala Thr Val Glu 
145                 150                 155                 160 


Thr Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala 
                165                 170                 175     


Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala Pro 
            180                 185                 190         


Ala Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala 
        195                 200                 205             


Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala Ala 
    210                 215                 220                 


Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Ser Ser His Tyr 
225                 230                 235                 240 


Leu Ser Cys Thr Ile Val Gly Ile Ile Val Leu Ile Val Leu Leu Ile 
                245                 250                 255     


Val Phe Val 
            


<210>  4
<211>  1512
<212>  DNA
<213>  Homo sapiens

<400>  4
gaggccatgc cccttttctg agtgcttgga agtgactgct gcaagtgaca agtgaccacg       60

ccttttcccc cgcgggtata aattcagagg cgctgcgctc cgattctggc agtgcagctg      120

tgggaacctc tccacgcgca cgaactcagc caacgatttc tgatagattt ttgggagttt      180

gaccagagat gcaaggggtg aaggagcgct tcctaccgtt agggaactct ggggacagag      240

cgccccggcc gcctgatggc cgaggcaggg tgcgacccag gacccaggac ggcgtcggga      300

accataccat ggcccggatc cccaagaccc taaagttcgt cgtcgtcatc gtcgcggtcc      360

tgctgccagt cctagcttac tctgccacca ctgcccggca ggaggaagtt ccccagcaga      420

cagtggcccc acagcaacag aggcacagct tcaaggggga ggagtgtcca gcaggatctc      480

atagatcaga acatactgga gcctgtaacc cgtgcacaga gggtgtggat tacaccaacg      540

cttccaacaa tgaaccttct tgcttcccat gtacagtttg taaatcagat caaaaacata      600

aaagttcctg caccatgacc agagacacag tgtgtcagtg taaagaaggc accttccgga      660

atgaaaactc cccagagatg tgccggaagt gtagcaggtg ccctagtggg gaagtccaag      720

tcagtaattg tacgtcctgg gatgatatcc agtgtgttga agaatttggt gccaatgcca      780

ctgtggaaac cccagctgct gaagagacaa tgaacaccag cccggggact cctgccccag      840

ctgctgaaga gacaatgaac accagcccag ggactcctgc cccagctgct gaagagacaa      900

tgaccaccag cccggggact cctgccccag ctgctgaaga gacaatgacc accagcccgg      960

ggactcctgc cccagctgct gaagagacaa tgaccaccag cccggggact cctgcctctt     1020

ctcattacct ctcatgcacc atcgtaggga tcatagttct aattgtgctt ctgattgtgt     1080

ttgtttgaaa gacttcactg tggaagaaat tccttcctta cctgaaaggt tcaggtaggc     1140

gctggctgag ggcggggggc gctggacact ctctgccctg cctccctctg ctgtgttccc     1200

acagacagaa acgcctgccc ctgccccaag tcctggtgtc tccagcctgg ctctatcttc     1260

ctccttgtga tcgtcccatc cccacatccc gtgcaccccc caggaccctg gtctcatcag     1320

tccctctcct ggagctgggg gtccacacat ctcccagcca agtccaagag ggcagggcca     1380

gttcctccca tcttcaggcc cagccaggca gggggcagtc ggctcctcaa ctgggtgaca     1440

agggtgagga tgagaagtgg tcacgggatt tattcagcct tggtcagagc agaaaaaaaa     1500

aaaaaaaaaa aa                                                         1512


<210>  5
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide forward primer for Homo sapiens DCR1 gene

<400>  5
ttacgcgtac gaatttagtt aac                                               23


<210>  6
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide reverse primer for Homo sapiens DCR1 gene

<400>  6
catcaaacga ccgaaacg                                                     18


<210>  7
<211>  127
<212>  DNA
<213>  Artificial

<220>
<223>  Bisulphite treated amplicon of Homo sapies DCR1 gene

<400>  7
ttacgcgtac gaatttagtt aacgattttt gatagatttt tgggagtttg attagagatg       60

taaggggtga aggagcgttt tttatcgtta gggaattttg gggatagagc gtttcggtcg      120

tttgatg                                                                127


<210>  8
<211>  127
<212>  DNA
<213>  Homo sapiens

<400>  8
ccacgcgcac gaactcagcc aacgatttct gatagatttt tgggagtttg accagagatg       60

caaggggtga aggagcgctt cctaccgtta gggaactctg gggacagagc gccccggccg      120

cctgatg                                                                127


