                         SEQUENCE LISTING

<110>  NLIFE THERAPEUTICS, S.L.
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF PARKINSON DISEASE 
       BY THE SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO 
       SPECIFIC NEURON TYPES

<130>  P8848PC00

<150>  EP12382414.6
       US61/719284
<151>  2012-10-26
       2012-10-26

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gapmer targeted to region 448-465 of alpha-synuclein mRNA

<400>  1
cuccaacatt tgtcacuu                                                     18


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gapmer targeted to region 499-516 of alpha-synuclein mRNA

<400>  2
cuccctccac tgtcuucu                                                     18


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gapmer targeted to region 502-519 of alpha-synuclein mRNA

<400>  3
cugctccctc cactgucu                                                     18


<210>  4
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  4
aagtgacaaa tgttggag                                                     18


<210>  5
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  5
agaagacagt ggagggag                                                     18


<210>  6
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  6
agacagtgga gggagcag                                                     18


<210>  7
<211>  3215
<212>  DNA
<213>  Homo sapiens

<400>  7
aggagaagga gaaggaggag gactaggagg aggaggacgg cgacgaccag aaggggccca       60

agagaggggg cgagcgaccg agcgccgcga cgcggaagtg aggtgcgtgc gggctgcagc      120

gcagaccccg gcccggcccc tccgagagcg tcctgggcgc tccctcacgc cttgccttca      180

agccttctgc ctttccaccc tcgtgagcgg agaactggga gtggccattc gacgacagtg      240

tggtgtaaag gaattcatta gccatggatg tattcatgaa aggactttca aaggccaagg      300

agggagttgt ggctgctgct gagaaaacca aacagggtgt ggcagaagca gcaggaaaga      360

caaaagaggg tgttctctat gtaggctcca aaaccaagga gggagtggtg catggtgtgg      420

caacagtggc tgagaagacc aaagagcaag tgacaaatgt tggaggagca gtggtgacgg      480

gtgtgacagc agtagcccag aagacagtgg agggagcagg gagcattgca gcagccactg      540

gctttgtcaa aaaggaccag ttgggcaaga atgaagaagg agccccacag gaaggaattc      600

tggaagatat gcctgtggat cctgacaatg aggcttatga aatgccttct gaggaagggt      660

atcaagacta cgaacctgaa gcctaagaaa tatctttgct cccagtttct tgagatctgc      720

tgacagatgt tccatcctgt acaagtgctc agttccaatg tgcccagtca tgacatttct      780

caaagttttt acagtgtatc tcgaagtctt ccatcagcag tgattgaagt atctgtacct      840

gcccccactc agcatttcgg tgcttccctt tcactgaagt gaatacatgg tagcagggtc      900

tttgtgtgct gtggattttg tggcttcaat ctacgatgtt aaaacaaatt aaaaacacct      960

aagtgactac cacttatttc taaatcctca ctattttttt gttgctgttg ttcagaagtt     1020

gttagtgatt tgctatcata tattataaga tttttaggtg tcttttaatg atactgtcta     1080

agaataatga cgtattgtga aatttgttaa tatatataat acttaaaaat atgtgagcat     1140

gaaactatgc acctataaat actaaatatg aaattttacc attttgcgat gtgttttatt     1200

cacttgtgtt tgtatataaa tggtgagaat taaaataaaa cgttatctca ttgcaaaaat     1260

attttatttt tatcccatct cactttaata ataaaaatca tgcttataag caacatgaat     1320

taagaactga cacaaaggac aaaaatataa agttattaat agccatttga agaaggagga     1380

attttagaag aggtagagaa aatggaacat taaccctaca ctcggaattc cctgaagcaa     1440

cactgccaga agtgtgtttt ggtatgcact ggttccttaa gtggctgtga ttaattattg     1500

aaagtggggt gttgaagacc ccaactacta ttgtagagtg gtctatttct cccttcaatc     1560

ctgtcaatgt ttgctttacg tattttgggg aactgttgtt tgatgtgtat gtgtttataa     1620

ttgttataca tttttaattg agccttttat taacatatat tgttattttt gtctcgaaat     1680

aattttttag ttaaaatcta ttttgtctga tattggtgtg aatgctgtac ctttctgaca     1740

ataaataata ttcgaccatg aataaaaaaa aaaaaaaagt gggttcccgg gaactaagca     1800

gtgtagaaga tgattttgac tacaccctcc ttagagagcc ataagacaca ttagcacata     1860

ttagcacatt caaggctctg agagaatgtg gttaactttg tttaactcag cattcctcac     1920

tttttttttt taatcatcag aaattctctc tctctctctc tctttttctc tcgctctctt     1980

tttttttttt tttttacagg aaatgccttt aaacatcgtt ggaactacca gagtcacctt     2040

aaaggagatc aattctctag actgataaaa atttcatggc ctcctttaaa tgttgccaaa     2100

tatatgaatt ctaggatttt tccttaggaa aggtttttct ctttcaggga agatctatta     2160

actccccatg ggtgctgaaa ataaacttga tggtgaaaaa ctctgtataa attaatttaa     2220

aaattatttg gtttctcttt ttaattattc tggggcatag tcatttctaa aagtcactag     2280

tagaaagtat aatttcaaga cagaatattc tagacatgct agcagtttat atgtattcat     2340

gagtaatgtg atatatattg ggcgctggtg aggaaggaag gaggaatgag tgactataag     2400

gatggttacc atagaaactt ccttttttac ctaattgaag agagactact acagagtgct     2460

aagctgcatg tgtcatctta cactagagag aaatggtaag tttcttgttt tatttaagtt     2520

atgtttaagc aaggaaagga tttgttattg aacagtatat ttcaggaagg ttagaaagtg     2580

gcggttagga tatattttaa atctacctaa agcagcatat tttaaaaatt taaaagtatt     2640

ggtattaaat taagaaatag aggacagaac tagactgata gcagtgacct agaacaattt     2700

gagattagga aagttgtgac catgaattta aggatttatg tggatacaaa ttctccttta     2760

aagtgtttct tcccttaata tttatctgac ggtaattttt gagcagtgaa ttactttata     2820

tatcttaata gtttatttgg gaccaaacac ttaaacaaaa agttctttaa gtcatataag     2880

ccttttcagg aagcttgtct catattcact cccgagacat tcacctgcca agtggcctga     2940

ggatcaatcc agtcctaggt ttattttgca gacttacatt ctcccaagtt attcagcctc     3000

atatgactcc acggtcggct ttaccaaaac agttcagagt gcactttggc acacaattgg     3060

gaacagaaca atctaatgtg tggtttggta ttccaagtgg ggtctttttc agaatctctg     3120

cactagtgtg agatgcaaac atgtttcctc atctttctgg cttatccagt atgtagctat     3180

ttgtgacata ataaatatat acatatatga aaata                                3215


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeted to region 499-517 of alpha-synuclein mRNA, sense 
       strand

<400>  8
agaagacagu ggagggagct t                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeted to region 499-517 of alpha-synuclein mRNA, 
       antisense strand

<400>  9
gcucccucca cugucuucut t                                                 21


<210>  10
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  10
ttggatgttg gcctagttct gtgtggaaga ctagtgattt tgttgttttt agataactaa       60

atcgacaaca aatcacagtc tgccatatgg cacaggccat gcctctacag                 110


<210>  11
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  11
ctggatacag agtggaccgg ctggccccat ctggaagact agtgattttg ttgttgtctt       60

actgcgctca acaacaaatc ccagtctacc taatggtgcc agccatcgca                 110


<210>  12
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  12
agattagagt ggctgtggtc tagtgctgtg tggaagacta gtgattttgt tgttctgatg       60

tactacgaca acaagtcaca gccggcctca tagcgcagac tcccttcgac                 110


<210>  13
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  13
ctcacagctg ccagtgtcat ttttgtgatc tgcagctagt attctcactc cagttgcata       60

gtcacaaaag tgatcattgg caggtgtggc                                        90


<210>  14
<211>  87
<212>  DNA
<213>  Homo sapiens

<400>  14
agcggtggcc agtgtcattt ttgtgatgtt gcagctagta atatgagccc agttgcatag       60

tcacaaaagt gatcattgga aactgtg                                           87


<210>  15
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  15
uggaagacua gugauuuugu ug                                                22


<210>  16
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  16
uugcauaguc acaaaaguga uc                                                22


<210>  17
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  17

His Ala Ile Tyr Pro Arg His 
1               5           


<210>  18
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  18

Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro 
1               5                   10          


<210>  19
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PNA probe

<400>  19
gaagacagtg gaggga                                                       16


