               SEQUENCE LISTING

<110> NOVARTIS AG

<120> USE OF IMMUNOMODULATORY COMPOUNDS FOR ENHANCING

<130> PAT054990-WO-PCT 

<160> 34

<170> BiSSAP 1.0

<210> 1
<211> 97
<212> PRT
<213> Staphylococcus aureus

<220> 
<221> SOURCE
<222> 1..97
<223> /mol_type="protein"
      /organism="Staphylococcus aureus"

<400> 1
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                   15    
Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                   25                  30        
Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                   40                  45            
Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                   55                  60                
Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                   70                  75                  80
Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                   90                  95    
Gln 
    

<210> 2
<211> 104
<212> PRT
<213> Staphylococcus aureus

<220> 
<221> SOURCE
<222> 1..104
<223> /mol_type="protein"
      /organism="Staphylococcus aureus"

<400> 2
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                   15    
Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Cys Gln 
            20                   25                  30        
Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu 
        35                   40                  45            
Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys 
    50                   55                  60                
Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile 
65                   70                  75                  80
Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys 
                85                   90                  95    
Gln Gly Leu Asp Arg Val Asn Pro 
            100                

<210> 3
<211> 207
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..207
<223> /mol_type="protein"
      /note="EscAB fusion protein"
      /organism="artificial sequences"

<400> 3
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                   15    
Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                   25                  30        
Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                   40                  45            
Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                   55                  60                
Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                   70                  75                  80
Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                   90                  95    
Gln Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala 
            100                  105                110        
Asp Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala 
        115                  120                125            
Lys Asp Ile Glu Ala Cys Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr 
    130                  135                140                
Ile Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp 
145                  150                155                  160
Val Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met 
                165                  170                175    
Ala Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys 
            180                  185                190        
Tyr Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                  200                205        

<210> 4
<211> 207
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..207
<223> /mol_type="protein"
      /note="EsxBA fusion protein"
      /organism="artificial sequences"

<400> 4
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                   15    
Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Cys Gln 
            20                   25                  30        
Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu 
        35                   40                  45            
Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys 
    50                   55                  60                
Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile 
65                   70                  75                  80
Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys 
                85                   90                  95    
Gln Gly Leu Asp Arg Val Asn Pro Ala Ser Gly Gly Gly Ser Met Ala 
            100                  105                110        
Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser Tyr 
        115                  120                125            
Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr Arg 
    130                  135                140                
Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser Arg 
145                  150                155                  160
Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe Ala 
                165                  170                175    
Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp Ala 
            180                  185                190        
Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
        195                  200                205        

<210> 5
<211> 6
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..6
<223> /mol_type="protein"
      /note="linker peptide"
      /organism="artificial sequences"

<400> 5
Ala Ser Gly Gly Gly Ser 
1               5    

<210> 6
<211> 205
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..205
<223> /mol_type="protein"
      /note="EsxAB fusion protein"
      /organism="artificial sequences"

<400> 6
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                   15    
Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                   25                  30        
Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                   40                  45            
Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                   55                  60                
Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                   70                  75                  80
Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                   90                  95    
Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly 
            100                  105                110        
Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp 
        115                  120                125            
Ile Glu Ala Cys Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu 
    130                  135                140                
Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu 
145                  150                155                  160
Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp 
                165                  170                175    
His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp 
            180                  185                190        
Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                  200                205

<210> 7
<211> 206
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..206
<223> /mol_type="protein"
      /note="EsxAB fusion protein with N-terminal methionine"
      /organism="artificial sequences"

<400> 7
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                   15    
Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                   25                  30        
Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                   40                  45            
Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                   55                  60                
Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                   70                  75                  80
Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                   90                  95    
Gln Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                  105                110        
Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                  120                125            
Asp Ile Glu Ala Cys Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile 
    130                  135                140                
Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val 
145                  150                155                  160
Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala 
                165                  170                175    
Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr 
            180                  185                190        
Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                  200                205    

<210> 8
<211> 302
<212> PRT
<213> Staphylococcus aureus

<220> 
<221> SOURCE
<222> 1..302
<223> /mol_type="protein"
      /organism="Staphylococcus aureus"

<400> 8
Met Lys Lys Leu Leu Leu Pro Leu Ile Ile Met Leu Leu Val Leu Ala 
1               5                   10                   15    
Ala Cys Gly Asn Gln Gly Glu Lys Asn Asn Lys Ala Glu Thr Lys Ser 
            20                   25                  30        
Tyr Lys Met Asp Asp Gly Lys Thr Val Asp Ile Pro Lys Asp Pro Lys 
        35                   40                  45            
Arg Ile Ala Val Val Ala Pro Thr Tyr Ala Gly Gly Leu Lys Lys Leu 
    50                   55                  60                
Gly Ala Asn Ile Val Ala Val Asn Gln Gln Val Asp Gln Ser Lys Val 
65                   70                  75                  80
Leu Lys Asp Lys Phe Lys Gly Val Thr Lys Ile Gly Asp Gly Asp Val 
                85                   90                  95    
Glu Lys Val Ala Lys Glu Lys Pro Asp Leu Ile Ile Val Tyr Ser Thr 
            100                  105                110        
Asp Lys Asp Ile Lys Lys Tyr Gln Lys Val Ala Pro Thr Val Val Val 
        115                  120                125            
Asp Tyr Asn Lys His Lys Tyr Leu Glu Gln Gln Glu Met Leu Gly Lys 
    130                  135                140                
Ile Val Gly Lys Glu Asp Lys Val Lys Ala Trp Lys Lys Asp Trp Glu 
145                  150                155                  160
Glu Thr Thr Ala Lys Asp Gly Lys Glu Ile Lys Lys Ala Ile Gly Gln 
                165                  170                175    
Asp Ala Thr Val Ser Leu Phe Asp Glu Phe Asp Lys Lys Leu Tyr Thr 
            180                  185                190        
Tyr Gly Asp Asn Trp Gly Arg Gly Gly Glu Val Leu Tyr Gln Ala Phe 
        195                  200                205            
Gly Leu Lys Met Gln Pro Glu Gln Gln Lys Leu Thr Ala Lys Ala Gly 
    210                  215                220                
Trp Ala Glu Val Lys Gln Glu Glu Ile Glu Lys Tyr Ala Gly Asp Tyr 
225                  230                235                  240
Ile Val Ser Thr Ser Glu Gly Lys Pro Thr Pro Gly Tyr Glu Ser Thr 
                245                  250                255    
Asn Met Trp Lys Asn Leu Lys Ala Thr Lys Glu Gly His Ile Val Lys 
            260                  265                270        
Val Asp Ala Gly Thr Tyr Trp Tyr Asn Asp Pro Tyr Thr Leu Asp Phe 
        275                  280                285            
Met Arg Lys Asp Leu Lys Glu Lys Leu Ile Lys Ala Ala Lys 
    290                  295                300        

<210> 9
<211> 285
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..285
<223> /mol_type="protein"
      /note="Sta006 mutant in which amino acids 1-17 have been deleted"
      /organism="Artificial Sequence"

<400> 9
Cys Gly Asn Gln Gly Glu Lys Asn Asn Lys Ala Glu Thr Lys Ser Tyr 
1               5                   10                   15    
Lys Met Asp Asp Gly Lys Thr Val Asp Ile Pro Lys Asp Pro Lys Arg 
            20                   25                  30        
Ile Ala Val Val Ala Pro Thr Tyr Ala Gly Gly Leu Lys Lys Leu Gly 
        35                   40                  45            
Ala Asn Ile Val Ala Val Asn Gln Gln Val Asp Gln Ser Lys Val Leu 
    50                   55                  60                
Lys Asp Lys Phe Lys Gly Val Thr Lys Ile Gly Asp Gly Asp Val Glu 
65                   70                  75                  80
Lys Val Ala Lys Glu Lys Pro Asp Leu Ile Ile Val Tyr Ser Thr Asp 
                85                   90                  95    
Lys Asp Ile Lys Lys Tyr Gln Lys Val Ala Pro Thr Val Val Val Asp 
            100                  105                110        
Tyr Asn Lys His Lys Tyr Leu Glu Gln Gln Glu Met Leu Gly Lys Ile 
        115                  120                125            
Val Gly Lys Glu Asp Lys Val Lys Ala Trp Lys Lys Asp Trp Glu Glu 
    130                  135                140                
Thr Thr Ala Lys Asp Gly Lys Glu Ile Lys Lys Ala Ile Gly Gln Asp 
145                  150                155                  160
Ala Thr Val Ser Leu Phe Asp Glu Phe Asp Lys Lys Leu Tyr Thr Tyr 
                165                  170                175    
Gly Asp Asn Trp Gly Arg Gly Gly Glu Val Leu Tyr Gln Ala Phe Gly 
            180                  185                190        
Leu Lys Met Gln Pro Glu Gln Gln Lys Leu Thr Ala Lys Ala Gly Trp 
        195                  200                205            
Ala Glu Val Lys Gln Glu Glu Ile Glu Lys Tyr Ala Gly Asp Tyr Ile 
    210                  215                220                
Val Ser Thr Ser Glu Gly Lys Pro Thr Pro Gly Tyr Glu Ser Thr Asn 
225                  230                235                  240
Met Trp Lys Asn Leu Lys Ala Thr Lys Glu Gly His Ile Val Lys Val 
                245                  250                255    
Asp Ala Gly Thr Tyr Trp Tyr Asn Asp Pro Tyr Thr Leu Asp Phe Met 
            260                  265                270        
Arg Lys Asp Leu Lys Glu Lys Leu Ile Lys Ala Ala Lys 
        275                  280                285

<210> 10
<211> 288
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..288
<223> /mol_type="protein"
      /note="Sta006 mutant with N-terminal Met-Ala-Ser sequence"
      /organism="Artificial Sequence"

<400> 10
Met Ala Ser Cys Gly Asn Gln Gly Glu Lys Asn Asn Lys Ala Glu Thr 
1               5                   10                   15    
Lys Ser Tyr Lys Met Asp Asp Gly Lys Thr Val Asp Ile Pro Lys Asp 
            20                   25                  30        
Pro Lys Arg Ile Ala Val Val Ala Pro Thr Tyr Ala Gly Gly Leu Lys 
        35                   40                  45            
Lys Leu Gly Ala Asn Ile Val Ala Val Asn Gln Gln Val Asp Gln Ser 
    50                   55                  60                
Lys Val Leu Lys Asp Lys Phe Lys Gly Val Thr Lys Ile Gly Asp Gly 
65                   70                  75                  80
Asp Val Glu Lys Val Ala Lys Glu Lys Pro Asp Leu Ile Ile Val Tyr 
                85                   90                  95    
Ser Thr Asp Lys Asp Ile Lys Lys Tyr Gln Lys Val Ala Pro Thr Val 
            100                  105                110        
Val Val Asp Tyr Asn Lys His Lys Tyr Leu Glu Gln Gln Glu Met Leu 
        115                  120                125            
Gly Lys Ile Val Gly Lys Glu Asp Lys Val Lys Ala Trp Lys Lys Asp 
    130                  135                140                
Trp Glu Glu Thr Thr Ala Lys Asp Gly Lys Glu Ile Lys Lys Ala Ile 
145                  150                155                  160
Gly Gln Asp Ala Thr Val Ser Leu Phe Asp Glu Phe Asp Lys Lys Leu 
                165                  170                175    
Tyr Thr Tyr Gly Asp Asn Trp Gly Arg Gly Gly Glu Val Leu Tyr Gln 
            180                  185                190        
Ala Phe Gly Leu Lys Met Gln Pro Glu Gln Gln Lys Leu Thr Ala Lys 
        195                  200                205            
Ala Gly Trp Ala Glu Val Lys Gln Glu Glu Ile Glu Lys Tyr Ala Gly 
    210                  215                220                
Asp Tyr Ile Val Ser Thr Ser Glu Gly Lys Pro Thr Pro Gly Tyr Glu 
225                  230                235                  240
Ser Thr Asn Met Trp Lys Asn Leu Lys Ala Thr Lys Glu Gly His Ile 
                245                  250                255    
Val Lys Val Asp Ala Gly Thr Tyr Trp Tyr Asn Asp Pro Tyr Thr Leu 
            260                  265                270        
Asp Phe Met Arg Lys Asp Leu Lys Glu Lys Leu Ile Lys Ala Ala Lys 
        275                  280                285            

<210> 11
<211> 256
<212> PRT
<213> Staphylococcus aureus

<220> 
<221> SOURCE
<222> 1..256
<223> /mol_type="protein"
      /organism="Staphylococcus aureus"

<400> 11
Met Met Lys Arg Leu Asn Lys Leu Val Leu Gly Ile Ile Phe Leu Phe 
1               5                   10                   15    
Leu Val Ile Ser Ile Thr Ala Gly Cys Gly Ile Gly Lys Glu Ala Glu 
            20                   25                  30        
Val Lys Lys Ser Phe Glu Lys Thr Leu Ser Met Tyr Pro Ile Lys Asn 
        35                   40                  45            
Leu Glu Asp Leu Tyr Asp Lys Glu Gly Tyr Arg Asp Asp Gln Phe Asp 
    50                   55                  60                
Lys Asn Asp Lys Gly Thr Trp Ile Ile Asn Ser Glu Met Val Ile Gln 
65                   70                  75                  80
Pro Asn Asn Glu Asp Met Val Ala Lys Gly Met Val Leu Tyr Met Asn 
                85                   90                  95    
Arg Asn Thr Lys Thr Thr Asn Gly Tyr Tyr Tyr Val Asp Val Thr Lys 
            100                  105                110        
Asp Glu Asp Glu Gly Lys Pro His Asp Asn Glu Lys Arg Tyr Pro Val 
        115                  120                125            
Lys Met Val Asp Asn Lys Ile Ile Pro Thr Lys Glu Ile Lys Asp Glu 
    130                  135                140                
Lys Ile Lys Lys Glu Ile Glu Asn Phe Lys Phe Phe Val Gln Tyr Gly 
145                  150                155                  160
Asp Phe Lys Asn Leu Lys Asn Tyr Lys Asp Gly Asp Ile Ser Tyr Asn 
                165                  170                175    
Pro Glu Val Pro Ser Tyr Ser Ala Lys Tyr Gln Leu Thr Asn Asp Asp 
            180                  185                190        
Tyr Asn Val Lys Gln Leu Arg Lys Arg Tyr Asp Ile Pro Thr Ser Lys 
        195                  200                205            
Ala Pro Lys Leu Leu Leu Lys Gly Ser Gly Asn Leu Lys Gly Ser Ser 
    210                  215                220                
Val Gly Tyr Lys Asp Ile Glu Phe Thr Phe Val Glu Lys Lys Glu Glu 
225                  230                235                  240
Asn Ile Tyr Phe Ser Asp Ser Leu Asp Tyr Lys Lys Ser Gly Asp Val 
                245                  250                255    

<210> 12
<211> 233
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..233
<223> /mol_type="protein"
      /note="Sta011 mutant in which amino acids 1-23 have been deleted"
      /organism="Artificial Sequence"

<400> 12
Gly Cys Gly Ile Gly Lys Glu Ala Glu Val Lys Lys Ser Phe Glu Lys 
1               5                   10                   15    
Thr Leu Ser Met Tyr Pro Ile Lys Asn Leu Glu Asp Leu Tyr Asp Lys 
            20                   25                  30        
Glu Gly Tyr Arg Asp Asp Gln Phe Asp Lys Asn Asp Lys Gly Thr Trp 
        35                   40                  45            
Ile Ile Asn Ser Glu Met Val Ile Gln Pro Asn Asn Glu Asp Met Val 
    50                   55                  60                
Ala Lys Gly Met Val Leu Tyr Met Asn Arg Asn Thr Lys Thr Thr Asn 
65                   70                  75                  80
Gly Tyr Tyr Tyr Val Asp Val Thr Lys Asp Glu Asp Glu Gly Lys Pro 
                85                   90                  95    
His Asp Asn Glu Lys Arg Tyr Pro Val Lys Met Val Asp Asn Lys Ile 
            100                  105                110        
Ile Pro Thr Lys Glu Ile Lys Asp Glu Lys Ile Lys Lys Glu Ile Glu 
        115                  120                125            
Asn Phe Lys Phe Phe Val Gln Tyr Gly Asp Phe Lys Asn Leu Lys Asn 
    130                  135                140                
Tyr Lys Asp Gly Asp Ile Ser Tyr Asn Pro Glu Val Pro Ser Tyr Ser 
145                  150                155                  160
Ala Lys Tyr Gln Leu Thr Asn Asp Asp Tyr Asn Val Lys Gln Leu Arg 
                165                  170                175    
Lys Arg Tyr Asp Ile Pro Thr Ser Lys Ala Pro Lys Leu Leu Leu Lys 
            180                  185                190        
Gly Ser Gly Asn Leu Lys Gly Ser Ser Val Gly Tyr Lys Asp Ile Glu 
        195                  200                205            
Phe Thr Phe Val Glu Lys Lys Glu Glu Asn Ile Tyr Phe Ser Asp Ser 
    210                  215                220                
Leu Asp Tyr Lys Lys Ser Gly Asp Val 
225                  230            

<210> 13
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..234
<223> /mol_type="protein"
      /note="Sta011 deletion mutant with N-terminal methionine"
      /organism="Artificial Sequence"

<400> 13
Met Gly Cys Gly Ile Gly Lys Glu Ala Glu Val Lys Lys Ser Phe Glu 
1               5                   10                   15    
Lys Thr Leu Ser Met Tyr Pro Ile Lys Asn Leu Glu Asp Leu Tyr Asp 
            20                   25                  30        
Lys Glu Gly Tyr Arg Asp Asp Gln Phe Asp Lys Asn Asp Lys Gly Thr 
        35                   40                  45            
Trp Ile Ile Asn Ser Glu Met Val Ile Gln Pro Asn Asn Glu Asp Met 
    50                   55                  60                
Val Ala Lys Gly Met Val Leu Tyr Met Asn Arg Asn Thr Lys Thr Thr 
65                   70                  75                  80
Asn Gly Tyr Tyr Tyr Val Asp Val Thr Lys Asp Glu Asp Glu Gly Lys 
                85                   90                  95    
Pro His Asp Asn Glu Lys Arg Tyr Pro Val Lys Met Val Asp Asn Lys 
            100                  105                110        
Ile Ile Pro Thr Lys Glu Ile Lys Asp Glu Lys Ile Lys Lys Glu Ile 
        115                  120                125            
Glu Asn Phe Lys Phe Phe Val Gln Tyr Gly Asp Phe Lys Asn Leu Lys 
    130                  135                140                
Asn Tyr Lys Asp Gly Asp Ile Ser Tyr Asn Pro Glu Val Pro Ser Tyr 
145                  150                155                  160
Ser Ala Lys Tyr Gln Leu Thr Asn Asp Asp Tyr Asn Val Lys Gln Leu 
                165                  170                175    
Arg Lys Arg Tyr Asp Ile Pro Thr Ser Lys Ala Pro Lys Leu Leu Leu 
            180                  185                190        
Lys Gly Ser Gly Asn Leu Lys Gly Ser Ser Val Gly Tyr Lys Asp Ile 
        195                  200                205            
Glu Phe Thr Phe Val Glu Lys Lys Glu Glu Asn Ile Tyr Phe Ser Asp 
    210                  215                220                
Ser Leu Asp Tyr Lys Lys Ser Gly Asp Val 
225                  230                

<210> 14
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..256
<223> /mol_type="protein"
      /note="Sta011 substitution mutant"
      /organism="Artificial Sequence"

<400> 14
Met Met Lys Arg Leu Asn Lys Leu Val Leu Gly Ile Ile Phe Leu Phe 
1               5                   10                   15    
Leu Val Ile Ser Ile Thr Ala Gly Cys Gly Ile Gly Lys Glu Ala Glu 
            20                   25                  30        
Val Lys Lys Ser Phe Glu Lys Thr Leu Ser Met Tyr Pro Ile Lys Asn 
        35                   40                  45            
Leu Glu Asp Leu Tyr Asp Lys Glu Gly Tyr Arg Asp Asp Gln Phe Asp 
    50                   55                  60                
Lys Asn Asp Lys Gly Thr Trp Ile Ile Asn Ser Glu Met Val Ile Gln 
65                   70                  75                  80
Pro Asn Asn Glu Asp Met Val Ala Lys Gly Met Val Leu Tyr Met Asn 
                85                   90                  95    
Arg Asn Thr Lys Thr Thr Asn Gly Tyr Tyr Tyr Val Asp Val Thr Lys 
            100                  105                110        
Asp Glu Asp Glu Gly Lys Pro His Asp Asn Glu Lys Arg Tyr Pro Val 
        115                  120                125            
Lys Met Val Asp Asn Lys Ile Ile Pro Thr Lys Glu Ile Lys Asp Glu 
    130                  135                140                
Lys Leu Lys Lys Glu Ile Glu Asn Phe Lys Phe Phe Val Gln Tyr Gly 
145                  150                155                  160
Asp Phe Lys Asn Ile Lys Asn Tyr Lys Asp Gly Asp Ile Ser Tyr Asn 
                165                  170                175    
Pro Glu Val Pro Ser Tyr Ser Ala Lys Tyr Gln Leu Thr Asn Asp Asp 
            180                  185                190        
Tyr Asn Val Lys Gln Leu Arg Lys Arg Tyr Asp Ile Pro Thr Ser Lys 
        195                  200                205            
Ala Pro Lys Leu Leu Leu Lys Gly Ser Gly Asn Leu Lys Gly Ser Ser 
    210                  215                220                
Val Gly Tyr Lys Asp Ile Glu Phe Thr Phe Val Glu Lys Lys Glu Glu 
225                  230                235                  240
Asn Ile Tyr Phe Ser Asp Ser Leu Asp Tyr Lys Lys Ser Gly Asp Val 
                245                  250                255    

<210> 15
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..256
<223> /mol_type="protein"
      /note="Sta011 substitution mutant"
      /organism="Artificial Sequence"

<400> 15
Met Met Lys Arg Leu Asn Lys Leu Val Leu Gly Ile Ile Phe Leu Phe 
1               5                   10                   15    
Leu Val Ile Ser Ile Thr Ala Gly Cys Gly Ile Gly Lys Glu Ala Glu 
            20                   25                  30        
Val Lys Lys Ser Phe Glu Lys Thr Leu Ser Met Tyr Pro Ile Lys Asn 
        35                   40                  45            
Leu Glu Asp Leu Tyr Asp Lys Glu Gly Tyr Arg Asp Asp Gln Phe Asp 
    50                   55                  60                
Lys Asn Asp Lys Gly Thr Trp Ile Ile Asn Ser Glu Met Val Ile Gln 
65                   70                  75                  80
Pro Asn Asn Glu Asp Met Val Ala Lys Gly Met Val Leu Tyr Met Asn 
                85                   90                  95    
Arg Asn Thr Lys Thr Thr Asn Gly Tyr Tyr Tyr Val Asp Val Thr Lys 
            100                  105                110        
Asp Glu Asp Glu Gly Lys Pro His Asp Asn Glu Lys Arg Tyr Pro Val 
        115                  120                125            
Lys Met Val Asp Asn Lys Ile Ile Pro Thr Lys Glu Ile Lys Asp Glu 
    130                  135                140                
Lys Val Lys Lys Glu Ile Glu Asn Phe Lys Phe Phe Val Gln Tyr Gly 
145                  150                155                  160
Asp Phe Lys Asn Ile Lys Asn Tyr Lys Asp Gly Asp Ile Ser Tyr Asn 
                165                  170                175    
Pro Glu Val Pro Ser Tyr Ser Ala Lys Tyr Gln Leu Thr Asn Asp Asp 
            180                  185                190        
Tyr Asn Val Lys Gln Leu Arg Lys Arg Tyr Asp Ile Pro Thr Ser Lys 
        195                  200                205            
Ala Pro Lys Leu Leu Leu Lys Gly Ser Gly Asn Leu Lys Gly Ser Ser 
    210                  215                220                
Val Gly Tyr Lys Asp Ile Glu Phe Thr Phe Val Glu Lys Lys Glu Glu 
225                  230                235                  240
Asn Ile Tyr Phe Ser Asp Ser Leu Asp Tyr Lys Lys Ser Gly Asp Val 
                245                  250                255    

<210> 16
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..256
<223> /mol_type="protein"
      /note="Sta011 substitution mutant"
      /organism="Artificial Sequence"

<400> 16
Met Met Lys Arg Leu Asn Lys Leu Val Leu Gly Ile Ile Phe Leu Phe 
1               5                   10                   15    
Leu Val Ile Ser Ile Thr Ala Gly Cys Gly Ile Gly Lys Glu Ala Glu 
            20                   25                  30        
Val Lys Lys Ser Phe Glu Lys Thr Leu Ser Met Tyr Pro Ile Lys Asn 
        35                   40                  45            
Leu Glu Asp Leu Tyr Asp Lys Glu Gly Tyr Arg Asp Asp Gln Phe Asp 
    50                   55                  60                
Lys Asn Asp Lys Gly Thr Trp Ile Ile Asn Ser Glu Met Val Ile Gln 
65                   70                  75                  80
Pro Asn Asn Glu Asp Met Val Ala Lys Gly Met Val Leu Tyr Met Asn 
                85                   90                  95    
Arg Asn Thr Lys Thr Thr Asn Gly Tyr Tyr Tyr Val Asp Val Thr Lys 
            100                  105                110        
Asp Glu Asp Glu Gly Lys Pro His Asp Asn Glu Lys Arg Tyr Pro Val 
        115                  120                125            
Lys Met Val Asp Asn Lys Ile Ile Pro Thr Lys Glu Ile Lys Asp Glu 
    130                  135                140                
Lys Leu Lys Lys Glu Ile Glu Asn Phe Lys Phe Phe Val Gln Tyr Gly 
145                  150                155                  160
Asp Phe Lys Asn Val Lys Asn Tyr Lys Asp Gly Asp Ile Ser Tyr Asn 
                165                  170                175    
Pro Glu Val Pro Ser Tyr Ser Ala Lys Tyr Gln Leu Thr Asn Asp Asp 
            180                  185                190        
Tyr Asn Val Lys Gln Leu Arg Lys Arg Tyr Asp Ile Pro Thr Ser Lys 
        195                  200                205            
Ala Pro Lys Leu Leu Leu Lys Gly Ser Gly Asn Leu Lys Gly Ser Ser 
    210                  215                220                
Val Gly Tyr Lys Asp Ile Glu Phe Thr Phe Val Glu Lys Lys Glu Glu 
225                  230                235                  240
Asn Ile Tyr Phe Ser Asp Ser Leu Asp Tyr Lys Lys Ser Gly Asp Val 
                245                  250                255    

<210> 17
<211> 319
<212> PRT
<213> Staphylococcus aureus

<220> 
<221> SOURCE
<222> 1..319
<223> /mol_type="protein"
      /organism="Staphylococcus aureus"

<400> 17
Met Lys Thr Arg Ile Val Ser Ser Val Thr Thr Thr Leu Leu Leu Gly 
1               5                   10                   15    
Ser Ile Leu Met Asn Pro Val Ala Asn Ala Ala Asp Ser Asp Ile Asn 
            20                   25                  30        
Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser Asn Thr Thr Val Lys Thr 
        35                   40                  45            
Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn Gly Met His Lys Lys Val 
    50                   55                  60                
Phe Tyr Ser Phe Ile Asp Asp Lys Asn His Asn Lys Lys Leu Leu Val 
65                   70                  75                  80
Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln Tyr Arg Val Tyr Ser Glu 
                85                   90                  95    
Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp Pro Ser Ala Phe Lys Val 
            100                  105                110        
Gln Leu Gln Leu Pro Asp Asn Glu Val Ala Gln Ile Ser Asp Tyr Tyr 
        115                  120                125            
Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr Met Ser Thr Leu Thr Tyr 
    130                  135                140                
Gly Phe Asn Gly Asn Val Thr Gly Asp Asp Thr Gly Lys Ile Gly Gly 
145                  150                155                  160
Leu Ile Gly Ala Asn Val Ser Ile Gly His Thr Leu Lys Tyr Val Gln 
                165                  170                175    
Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro Thr Asp Lys Lys Val Gly 
            180                  185                190        
Trp Lys Val Ile Phe Asn Asn Met Val Asn Gln Asn Trp Gly Pro Tyr 
        195                  200                205            
Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly Asn Gln Leu Phe Met Lys 
    210                  215                220                
Thr Arg Asn Gly Ser Met Lys Ala Ala Asp Asn Phe Leu Asp Pro Asn 
225                  230                235                  240
Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe Ser Pro Asp Phe Ala Thr 
                245                  250                255    
Val Ile Thr Met Asp Arg Lys Ala Ser Lys Gln Gln Thr Asn Ile Asp 
            260                  265                270        
Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr Gln Leu His Trp Thr Ser 
        275                  280                285            
Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp Lys Trp Ile Asp Arg Ser 
    290                  295                300                
Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys Glu Glu Met Thr Asn 
305                  310                315                

<210> 18
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..293
<223> /mol_type="protein"
      /note="Hla mutant in which amino acids 1-26 have been deleted"
      /organism="Artificial Sequence"

<400> 18
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                   55                  60                
Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                   70                  75                  80
Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                   90                  95    
Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                  105                110        
Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                  120                125            
Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                  135                140                
Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                  150                155                  160
Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                  170                175    
Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                  185                190        
Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                  200                205            
Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                  215                220                
Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                  230                235                  240
Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                  250                255    
Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                  265                270        
Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                  280                285            
Glu Glu Met Thr Asn 
    290            

<210> 19
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..293
<223> /mol_type="protein"
      /note="Hla substitution mutant (H35L)"
      /organism="Artificial Sequence"

<400> 19
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                   55                  60                
Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                   70                  75                  80
Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                   90                  95    
Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                  105                110        
Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                  120                125            
Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                  135                140                
Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                  150                155                  160
Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                  170                175    
Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                  185                190        
Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                  200                205            
Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                  215                220                
Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                  230                235                  240
Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                  250                255    
Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                  265                270        
Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                  280                285            
Glu Glu Met Thr Asn 
    290            

<210> 20
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..4
<223> /mol_type="protein"
      /note="loop replacement sequence"
      /organism="Artificial Sequence"

<400> 20
Pro Ser Gly Ser 
1               

<210> 21
<211> 258
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..258
<223> /mol_type="protein"
      /note="Hla loop replacement mutant (H35L)"
      /organism="Artificial Sequence"

<400> 21
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                   55                  60                
Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                   70                  75                  80
Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                   90                  95    
Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Pro Ser Gly 
            100                  105                110        
Ser Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro Thr Asp Lys 
        115                  120                125            
Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn Gln Asn Trp 
    130                  135                140                
Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly Asn Gln Leu 
145                  150                155                  160
Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp Asn Phe Leu 
                165                  170                175    
Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe Ser Pro Asp 
            180                  185                190        
Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys Gln Gln Thr 
        195                  200                205            
Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr Gln Leu His 
    210                  215                220                
Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp Lys Trp Ile 
225                  230                235                  240
Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys Glu Glu Met 
                245                  250                255    
Thr Asn 
        

<210> 22
<211> 258
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..258
<223> /mol_type="protein"
      /note="Hla loop replacement mutant"
      /organism="Artificial Sequence"

<400> 22
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                   55                  60                
Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                   70                  75                  80
Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                   90                  95    
Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Pro Ser Gly 
            100                  105                110        
Ser Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro Thr Asp Lys 
        115                  120                125            
Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn Gln Asn Trp 
    130                  135                140                
Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly Asn Gln Leu 
145                  150                155                  160
Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp Asn Phe Leu 
                165                  170                175    
Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe Ser Pro Asp 
            180                  185                190        
Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys Gln Gln Thr 
        195                  200                205            
Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr Gln Leu His 
    210                  215                220                
Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp Lys Trp Ile 
225                  230                235                  240
Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys Glu Glu Met 
                245                  250                255    
Thr Asn 
        

<210> 23
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..293
<223> /mol_type="protein"
      /note="Hla substitution mutant (Y101L)"
      /organism="Artificial Sequence"

<400> 23
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                   55                  60                
Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                   70                  75                  80
Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                   90                  95    
Gln Ile Ser Asp Leu Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                  105                110        
Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                  120                125            
Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                  135                140                
Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                  150                155                  160
Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                  170                175    
Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                  185                190        
Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                  200                205            
Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                  215                220                
Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                  230                235                  240
Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                  250                255    
Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                  265                270        
Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                  280                285            
Glu Glu Met Thr Asn 
    290            

<210> 24
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..293
<223> /mol_type="protein"
      /note="Hla substitution mutant (D152L)"
      /organism="Artificial Sequence"

<400> 24
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                   55                  60                
Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                   70                  75                  80
Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                   90                  95    
Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                  105                110        
Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                  120                125            
Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                  135                140                
Thr Leu Lys Tyr Val Gln Pro Leu Phe Lys Thr Ile Leu Glu Ser Pro 
145                  150                155                  160
Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                  170                175    
Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                  185                190        
Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                  200                205            
Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                  215                220                
Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                  230                235                  240
Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                  250                255    
Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                  265                270        
Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                  280                285            
Glu Glu Met Thr Asn 
    290            

<210> 25
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..293
<223> /mol_type="protein"
      /note="Hla substitution mutant (H35L, Y101L)"
      /organism="Artificial Sequence"

<400> 25
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                   55                  60                
Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                   70                  75                  80
Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                   90                  95    
Gln Ile Ser Asp Leu Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                  105                110        
Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                  120                125            
Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                  135                140                
Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                  150                155                  160
Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                  170                175    
Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                  185                190        
Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                  200                205            
Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                  215                220                
Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                  230                235                  240
Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                  250                255    
Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                  265                270        
Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                  280                285            
Glu Glu Met Thr Asn 
    290            

<210> 26
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..293
<223> /mol_type="protein"
      /note="Hla substitution mutant (H35L, D152L)"
      /organism="Artificial Sequence"

<400> 26
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                   55                  60                
Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                   70                  75                  80
Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                   90                  95    
Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                  105                110        
Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                  120                125            
Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                  135                140                
Thr Leu Lys Tyr Val Gln Pro Leu Phe Lys Thr Ile Leu Glu Ser Pro 
145                  150                155                  160
Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                  170                175    
Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                  185                190        
Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                  200                205            
Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                  215                220                
Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                  230                235                  240
Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                  250                255    
Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                  265                270        
Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                  280                285            
Glu Glu Met Thr Asn 
    290            

<210> 27
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..50
<223> /mol_type="protein"
      /note="Residues 27-76 of SEQ ID NO. 17"
      /organism="Artificial Sequence"

<400> 27
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys 
    50

<210> 28
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..63
<223> /mol_type="protein"
      /note="Residues 27-89 of SEQ ID NO. 17"
      /organism="Artificial Sequence"

<400> 28
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly 
    50                   55                  60            

<210> 29
<211> 53
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..53
<223> /mol_type="protein"
      /note="Residues 27-79 of SEQ ID NO. 17"
      /organism="Artificial Sequence"

<400> 29
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu 
    50            

<210> 30
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..50
<223> /mol_type="protein"
      /note="Residues 27-76 of SEQ ID NO. 19"
      /organism="Artificial Sequence"

<400> 30
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys 
    50

<210> 31
<211> 63
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..63
<223> /mol_type="protein"
      /note="Residues 27-89 of SEQ ID NO. 19"
      /organism="Artificial Sequence"

<400> 31
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly 
    50                   55                  60            

<210> 32
<211> 53
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..53
<223> /mol_type="protein"
      /note="Residues 27-79 of SEQ ID NO. 19"
      /organism="Artificial Sequence"

<400> 32
Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                   15    
Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                   25                  30        
Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                   40                  45            
Asn Lys Lys Leu Leu 
    50            

<210> 33
<211> 296
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..296
<223> /mol_type="protein"
      /note="Hla mutant"
      /organism="Artificial Sequence"

<400> 33
Met Ala Ser Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp 
1               5                   10                   15    
Ile Gly Ser Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp 
            20                   25                  30        
Lys Glu Asn Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp 
        35                   40                  45            
Lys Asn His Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile 
    50                   55                  60                
Ala Gly Gln Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly 
65                   70                  75                  80
Leu Ala Trp Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn 
                85                   90                  95    
Glu Val Ala Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr 
            100                  105                110        
Lys Glu Tyr Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr 
        115                  120                125            
Gly Asp Asp Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser 
    130                  135                140                
Ile Gly His Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu 
145                  150                155                  160
Glu Ser Pro Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn 
                165                  170                175    
Met Val Asn Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro 
            180                  185                190        
Val Tyr Gly Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys 
        195                  200                205            
Ala Ala Asp Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser 
    210                  215                220                
Ser Gly Phe Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys 
225                  230                235                  240
Ala Ser Lys Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg 
                245                  250                255    
Asp Asp Tyr Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn 
            260                  265                270        
Thr Lys Asp Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp 
        275                  280                285            
Trp Glu Lys Glu Glu Met Thr Asn 
    290                  295    

<210> 34
<211> 888
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..888
<223> /mol_type="DNA"
      /note="Expression vector for protein encoded by SEQ ID NO. 33"
      /organism="Artificial Sequence"

<400> 34
atggctagcg cagattctga tattaatatt aaaaccggta ctacagatat tggaagcaat      60

actacagtaa aaacaggtga tttagtcact tatgataaag aaaatggcat gttaaaaaaa     120

gtattttata gttttatcga tgataaaaat cataataaaa aactgctagt tattagaacg     180

aaaggtacca ttgctggtca atatagagtt tatagcgaag aaggtgctaa caaaagtggt     240

ttagcctggc cttcagcctt taaggtacag ttgcaactac ctgataatga agtagctcaa     300

atatctgatt actatccaag aaattcgatt gatacaaaag agtatatgag tactttaact     360

tatggattca acggtaatgt tactggtgat gatacaggaa aaattggcgg ccttattggt     420

gcaaatgttt cgattggtca tacactgaaa tatgttcaac ctgatttcaa aacaatttta     480

gagagcccaa ctgataaaaa agtaggctgg aaagtgatat ttaacaatat ggtgaatcaa     540

aattggggac catatgatag agattcttgg aacccggtat atggcaatca acttttcatg     600

aaaactagaa atggctctat gaaagcagca gataacttcc ttgatcctaa caaagcaagt     660

tctctattat cttcagggtt ttcaccagac ttcgctacag ttattactat ggatagaaaa     720

gcatccaaac aacaaacaaa tatagatgta atatacgaac gagttcgtga tgactaccaa     780

ttgcactgga cttcaacaaa ttggaaaggt accaatacta aagataaatg gatagatcgt     840

tcttcagaaa gatataaaat cgattgggaa aaagaagaaa tgacaaat                  888


