                         SEQUENCE LISTING

<110>  Securetec Detektions-Systeme AG
 
<120>  Verfahren und Vorrichtung zum Nachweis von illegalen Drogen

<130>  53936P EP

<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  5732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5732)
<223>  Nucleotide sequence of human cannabinoid receptor 1

<400>  1
gcgccggcgc cgcctcccgc acgctactcc ctctgccacc ccttccttct ccacttcttt     60

tccgcctccg cctcttcttg tctcccgcgg cgccagcgcc ttcccttggc ccgggcgggg    120

gcctcggctc cctgcagagc tctccgtagt cagtggggga tatttcgttc tagcggacaa    180

ccagcccctg agctgggcga gaggtgccaa gggagcttct gtcccgagga ccaggggatg    240

cgaagggatt gccccctgtg ggtcactttc tcagtcattt tgagctcagc ctaatcaaag    300

actgaggtta tgaagtcgat cctagatggc cttgcagata ccaccttccg caccatcacc    360

actgacctcc tgtacgtggg ctcaaatgac attcagtacg aagacatcaa aggtgacatg    420

gcatccaaat tagggtactt cccacagaaa ttccctttaa cttcctttag gggaagtccc    480

ttccaagaga agatgactgc gggagacaac ccccagctag tcccagcaga ccaggtgaac    540

attacagaat tttacaacaa gtctctctcg tccttcaagg agaatgagga gaacatccag    600

tgtggggaga acttcatgga catagagtgt ttcatggtcc tgaaccccag ccagcagctg    660

gccattgcag tcctgtccct cacgctgggc accttcacgg tcctggagaa cctcctggtg    720

ctgtgcgtca tcctccactc ccgcagcctc cgctgcaggc cttcctacca cttcatcggc    780

agcctggcgg tggcagacct cctggggagt gtcatttttg tctacagctt cattgacttc    840

cacgtgttcc accgcaaaga tagccgcaac gtgtttctgt tcaaactggg tggggtcacg    900

gcctccttca ctgcctccgt gggcagcctg ttcctcacag ccatcgacag gtacatatcc    960

attcacaggc ccctggccta taagaggatt gtcaccaggc ccaaggccgt ggtggcgttt   1020

tgcctgatgt ggaccatagc cattgtgatc gccgtgctgc ctctcctggg ctggaactgc   1080

gagaaactgc aatctgtttg ctcagacatt ttcccacaca ttgatgaaac ctacctgatg   1140

ttctggatcg gggtcaccag cgtactgctt ctgttcatcg tgtatgcgta catgtatatt   1200

ctctggaagg ctcacagcca cgccgtccgc atgattcagc gtggcaccca gaagagcatc   1260

atcatccaca cgtctgagga tgggaaggta caggtgaccc ggccagacca agcccgcatg   1320

gacattaggt tagccaagac cctggtcctg atcctggtgg tgttgatcat ctgctggggc   1380

cctctgcttg caatcatggt gtatgatgtc tttgggaaga tgaacaagct cattaagacg   1440

gtgtttgcat tctgcagtat gctctgcctg ctgaactcca ccgtgaaccc catcatctat   1500

gctctgagga gtaaggacct gcgacacgct ttccggagca tgtttccctc ttgtgaaggc   1560

actgcgcagc ctctggataa cagcatgggg gactcggact gcctgcacaa acacgcaaac   1620

aatgcagcca gtgttcacag ggccgcagaa agctgcatca agagcacggt caagattgcc   1680

aaggtaacca tgtctgtgtc cacagacacg tctgccgagg ctctgtgagc ctgatgcctc   1740

cctggcagca caggaaaaga attttttttt ttaagctcaa aatctagaag agtctattgt   1800

ctccttggtt atattttttt aactttacca tgctcaatga aaaggtgatt gtcaccatga   1860

tcacttatca gtttgctaat gtttccatag tttaggtact caaactccat tctccagggg   1920

tttacagtga agaaagcctg ttgtttaagt gactgaacga tccttcaaag tctcaatgaa   1980

ataggaggga aacctttggc tacacaattg gaagtctaag aacccatgga aaaatgccat   2040

caaatgaata atgcctttgt aaccacaact ttcactataa tgtgaaatgt aactgtccgt   2100

agtatcagag atgtccattt ttacaagtta tagtactaga gatattttgt aaaatgtatt   2160

atgtcctgtg agatgtgtat cagtgtttat gtgctattaa tatttgttta gttcagcaaa   2220

actgaaaggt agacttttat gagaacaatg gacaagcagt ggatacgtgt caatgtgtgc   2280

actttttttc tatattattg cccatgatat aactttagaa ataaacctta atatttcttc   2340

aaatatctct atttaatttt gacactgaaa taaccgtaaa ggtttatttt tctgttacct   2400

caacaagaag aatttgaaga cttcaaaata ttgagcagaa ttcattcata cttaaaaatt   2460

tattagccct gcattttcat aggaagacac attatcttct ggactatagc tgttctaatg   2520

gattataatc agaatggaag agagaaagca tattgacttt ttttgagcga catctctgac   2580

tttctttagt ctttagctat tactggatct cttaagacag catgtgttaa tcttaatgta   2640

tatcgttatc actgtgcagt tgctgtttac ttgaatagta ttgtgttcct atattccagg   2700

tttaagtaga tttcatgcct gggtggccaa acaacagtct tcattttttt taattgaaaa   2760

gaagtagtgt ctggatcagt aaaattatac tgtgtgtgag tgtgaatata aatgtgtgta   2820

tgtgtgtttc tgtcctgtaa ctgttacagt aatgtcataa agtgagaaaa ctgtgaccaa   2880

gtataaactt ttaccacttg ctgcactctt gcacatggat tcagtttcta aaattgagtt   2940

cttcctgtaa tcttgttgat aaaaatactg actccaacca ttcaaaaatt tcaccccatc   3000

cctccttaag agattggatc aagtattact aaattgacct ttaggtatta cacaagacca   3060

gtgcttagca aaaaataatg acaggcatcc aaggaaggga tgtatttgta gtgttattgc   3120

caggaaagga gagtactttg gtttctgagc accgaatatt gagcaatatg tcagtcacta   3180

aaaggaagac agttctacag aaaaacaatg gtaacatttt tcaatagcgt gtgtagatag   3240

tatgcactat atacatcacg ttaaagtagg actatcacac ccagcccatg tggctaaaaa   3300

agctgaatca gacagtggat gagacacaca acggcagtga agaaccgata cacttggcat   3360

tgacgtctag ctatgctgta tctgtgcttt gcccacatgc ccttggtgac agctgagcac   3420

ccagctctgt cttggtaggt ttgggctaag gaacaaatct ctcctttgct cgtggttagc   3480

aagatacact caagcatgaa gataaacaca gctgctttct tcttacaccc cggtctcatg   3540

ctccttaatg gcgccatggg tgcttgttgg gcctttttcc agtaaggaat gatattgctg   3600

aagaatctac ttaaccctga caaattttaa ttataatctc ttcttataca gataaaacat   3660

gactcctaca aggccccaag gtttacatag tctgaagtga agtacagagc tggcatctat   3720

ctggtgattt ctagctctcg agatacccaa gcagcctgat ggggcagttc cccttcttac   3780

ggttcacgct ctaaggcagg atgtggctta tgagatactt tgcattgtct gtctgcacac   3840

cttgaatctg cctgctggct cccttacttt acctctctgt catgtgcaga tgaaggctca   3900

gggtgctaga ggattagtaa gatctctttc taaagacagg agagattatt tacaagaaga   3960

actcaccagg gtttagtttg catttaagaa ttgccagtct tttgtcctgc atcatcttga   4020

acattaatcc acatgtttca gagctcacca ggcagtacca atgctctttt cacagctatg   4080

aagagctaga gaaattcttg ttatggtaga aaaatttcac gattcatttt tgaaactgca   4140

tttgtgcgta tgcagtgtag attttatagt gtgttgtgct ttcaagatct aaatcatata   4200

taataaatta agggacaatg gggctgacag cactaaactt ggtgcttatt gatattctaa   4260

gaaatatctg tgaaatatca tcacgtatgt tatacaacct tcatttaaaa aggtttaaaa   4320

ctagttagat tcactttgac acttttcata tcatttctta acccaagtga cgaaaacatt   4380

gtccccaatg aatatactca ttagaattac catttgttaa tatcactcat taattaaccc   4440

cataattaga tccattaatt taaatgattt aaatttaagt aagttttata aggtctgaca   4500

tcagaggtat cttactttcc tctgaggatg atgtacttgc cctgaccatg cattttacca   4560

tcacacatgt tcagaaaggg ccaaattccc aacctgctca tttttttttt atcagagtca   4620

tgatgaatca gtcctagaat gtttcatttg cacaagtagg gctgcctcca agaggaacct   4680

ctgatttatt ttgtatgaaa tatatgtgaa aggatatgaa tctgagagat gctgtagaca   4740

tctgtcctac acttgagatg atttccaagc ctctctggca ctttgagtta agtctatctg   4800

gtattaaatg ccaaggacct tttgctgcct aaatccactc tgcaggaaat aggcccaacc   4860

accagatgag aattaggccc tggatgagta gcgctatagt tactgtcctg ttgattaatt   4920

tctgccattt catgtccata aaagagacca cccatatcat gcacacaatt agatttctca   4980

cactctaact gtatatttgt atgatatttt aaaatctcct aaatgctggg caatggctat   5040

taacaattaa ttgtcttgca ctggccttct gatgaaatgt taacaatgcc tattgtaata   5100

tagaaaaaaa cattctatct actgatttgg gctgaatgta tgtaaatagg tttctaaaaa   5160

gtcagatgtt tgagcagtgg cctacaaatc agtaattttc ggatgggaga gtttctttac   5220

attgccgtgg catcttaaaa gctatcttca tgtaaattga ctgtactagg cctactgggg   5280

atcagagttc ccaagaaagg aaaccttttc ttgtatctgg attcaaattt atttccaatg   5340

tttcaagcgg gaaacatgac tctttattgt ctgtaaatct aacattatta cttttcctct   5400

tagaagaata ttgtattgtt agatgtttgt tgagctggta acatcgttgc aaccactgca   5460

atatcttcgt tagtaatctg tataatactt tgtatacaag tactggtaag attgttatta   5520

aatgtagctt cagtcattaa attactatag caaagtagta cttcttctgt aatatttaca   5580

atgtattaag cccacagtat attttatttc aatgtaatta aactgttaac ttattcaaag   5640

agaaaacatc tcatcatgtc tattgtccaa agttacctgg aatcaaataa aaattctaga   5700

ttaccatgaa gaacataaaa aaaaaaaaaa aa                                 5732


<210>  2
<211>  472
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(472)
<223>  Amino acid sequence of human cannabinoid receptor 1

<400>  2

Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile 
1               5                   10                  15      


Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe 
        35                  40                  45              


Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala 
    50                  55                  60                  


Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu 
65                  70                  75                  80  


Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile 
                85                  90                  95      


Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn 
            100                 105                 110         


Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr 
        115                 120                 125             


Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser 
    130                 135                 140                 


Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala 
145                 150                 155                 160 


Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp 
                165                 170                 175     


Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys 
            180                 185                 190         


Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe 
        195                 200                 205             


Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr 
    210                 215                 220                 


Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met 
225                 230                 235                 240 


Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn 
                245                 250                 255     


Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp 
            260                 265                 270         


Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu 
        275                 280                 285             


Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His 
    290                 295                 300                 


Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His 
305                 310                 315                 320 


Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg 
                325                 330                 335     


Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu 
            340                 345                 350         


Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe 
        355                 360                 365             


Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met 
    370                 375                 380                 


Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg 
385                 390                 395                 400 


Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu 
                405                 410                 415     


Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu 
            420                 425                 430         


His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser 
        435                 440                 445             


Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser 
    450                 455                 460                 


Thr Asp Thr Ser Ala Glu Ala Leu 
465                 470         


<210>  3
<211>  5387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5387)
<223>  Nucleotide sequence of human cannabinoid receptor 2

<400>  3
gattgccccc tgtgggtcac tttctcagtc attttgagct cagcctaatc aaagactgag     60

gttatgaagt cgatcctaga tggccttgca gataccacct tccgcaccat caccactgac    120

ctcctgggaa gtcccttcca agagaagatg actgcgggag acaaccccca gctagtccca    180

gcagaccagg tgaacattac agaattttac aacaagtctc tctcgtcctt caaggagaat    240

gaggagaaca tccagtgtgg ggagaacttc atggacatag agtgtttcat ggtcctgaac    300

cccagccagc agctggccat tgcagtcctg tccctcacgc tgggcacctt cacggtcctg    360

gagaacctcc tggtgctgtg cgtcatcctc cactcccgca gcctccgctg caggccttcc    420

taccacttca tcggcagcct ggcggtggca gacctcctgg ggagtgtcat ttttgtctac    480

agcttcattg acttccacgt gttccaccgc aaagatagcc gcaacgtgtt tctgttcaaa    540

ctgggtgggg tcacggcctc cttcactgcc tccgtgggca gcctgttcct cacagccatc    600

gacaggtaca tatccattca caggcccctg gcctataaga ggattgtcac caggcccaag    660

gccgtggtgg cgttttgcct gatgtggacc atagccattg tgatcgccgt gctgcctctc    720

ctgggctgga actgcgagaa actgcaatct gtttgctcag acattttccc acacattgat    780

gaaacctacc tgatgttctg gatcggggtc accagcgtac tgcttctgtt catcgtgtat    840

gcgtacatgt atattctctg gaaggctcac agccacgccg tccgcatgat tcagcgtggc    900

acccagaaga gcatcatcat ccacacgtct gaggatggga aggtacaggt gacccggcca    960

gaccaagccc gcatggacat taggttagcc aagaccctgg tcctgatcct ggtggtgttg   1020

atcatctgct ggggccctct gcttgcaatc atggtgtatg atgtctttgg gaagatgaac   1080

aagctcatta agacggtgtt tgcattctgc agtatgctct gcctgctgaa ctccaccgtg   1140

aaccccatca tctatgctct gaggagtaag gacctgcgac acgctttccg gagcatgttt   1200

ccctcttgtg aaggcactgc gcagcctctg gataacagca tgggggactc ggactgcctg   1260

cacaaacacg caaacaatgc agccagtgtt cacagggccg cagaaagctg catcaagagc   1320

acggtcaaga ttgccaaggt aaccatgtct gtgtccacag acacgtctgc cgaggctctg   1380

tgagcctgat gcctccctgg cagcacagga aaagaatttt tttttttaag ctcaaaatct   1440

agaagagtct attgtctcct tggttatatt tttttaactt taccatgctc aatgaaaagg   1500

tgattgtcac catgatcact tatcagtttg ctaatgtttc catagtttag gtactcaaac   1560

tccattctcc aggggtttac agtgaagaaa gcctgttgtt taagtgactg aacgatcctt   1620

caaagtctca atgaaatagg agggaaacct ttggctacac aattggaagt ctaagaaccc   1680

atggaaaaat gccatcaaat gaataatgcc tttgtaacca caactttcac tataatgtga   1740

aatgtaactg tccgtagtat cagagatgtc catttttaca agttatagta ctagagatat   1800

tttgtaaaat gtattatgtc ctgtgagatg tgtatcagtg tttatgtgct attaatattt   1860

gtttagttca gcaaaactga aaggtagact tttatgagaa caatggacaa gcagtggata   1920

cgtgtcaatg tgtgcacttt ttttctatat tattgcccat gatataactt tagaaataaa   1980

ccttaatatt tcttcaaata tctctattta attttgacac tgaaataacc gtaaaggttt   2040

atttttctgt tacctcaaca agaagaattt gaagacttca aaatattgag cagaattcat   2100

tcatacttaa aaatttatta gccctgcatt ttcataggaa gacacattat cttctggact   2160

atagctgttc taatggatta taatcagaat ggaagagaga aagcatattg actttttttg   2220

agcgacatct ctgactttct ttagtcttta gctattactg gatctcttaa gacagcatgt   2280

gttaatctta atgtatatcg ttatcactgt gcagttgctg tttacttgaa tagtattgtg   2340

ttcctatatt ccaggtttaa gtagatttca tgcctgggtg gccaaacaac agtcttcatt   2400

ttttttaatt gaaaagaagt agtgtctgga tcagtaaaat tatactgtgt gtgagtgtga   2460

atataaatgt gtgtatgtgt gtttctgtcc tgtaactgtt acagtaatgt cataaagtga   2520

gaaaactgtg accaagtata aacttttacc acttgctgca ctcttgcaca tggattcagt   2580

ttctaaaatt gagttcttcc tgtaatcttg ttgataaaaa tactgactcc aaccattcaa   2640

aaatttcacc ccatccctcc ttaagagatt ggatcaagta ttactaaatt gacctttagg   2700

tattacacaa gaccagtgct tagcaaaaaa taatgacagg catccaagga agggatgtat   2760

ttgtagtgtt attgccagga aaggagagta ctttggtttc tgagcaccga atattgagca   2820

atatgtcagt cactaaaagg aagacagttc tacagaaaaa caatggtaac atttttcaat   2880

agcgtgtgta gatagtatgc actatataca tcacgttaaa gtaggactat cacacccagc   2940

ccatgtggct aaaaaagctg aatcagacag tggatgagac acacaacggc agtgaagaac   3000

cgatacactt ggcattgacg tctagctatg ctgtatctgt gctttgccca catgcccttg   3060

gtgacagctg agcacccagc tctgtcttgg taggtttggg ctaaggaaca aatctctcct   3120

ttgctcgtgg ttagcaagat acactcaagc atgaagataa acacagctgc tttcttctta   3180

caccccggtc tcatgctcct taatggcgcc atgggtgctt gttgggcctt tttccagtaa   3240

ggaatgatat tgctgaagaa tctacttaac cctgacaaat tttaattata atctcttctt   3300

atacagataa aacatgactc ctacaaggcc ccaaggttta catagtctga agtgaagtac   3360

agagctggca tctatctggt gatttctagc tctcgagata cccaagcagc ctgatggggc   3420

agttcccctt cttacggttc acgctctaag gcaggatgtg gcttatgaga tactttgcat   3480

tgtctgtctg cacaccttga atctgcctgc tggctccctt actttacctc tctgtcatgt   3540

gcagatgaag gctcagggtg ctagaggatt agtaagatct ctttctaaag acaggagaga   3600

ttatttacaa gaagaactca ccagggttta gtttgcattt aagaattgcc agtcttttgt   3660

cctgcatcat cttgaacatt aatccacatg tttcagagct caccaggcag taccaatgct   3720

cttttcacag ctatgaagag ctagagaaat tcttgttatg gtagaaaaat ttcacgattc   3780

atttttgaaa ctgcatttgt gcgtatgcag tgtagatttt atagtgtgtt gtgctttcaa   3840

gatctaaatc atatataata aattaaggga caatggggct gacagcacta aacttggtgc   3900

ttattgatat tctaagaaat atctgtgaaa tatcatcacg tatgttatac aaccttcatt   3960

taaaaaggtt taaaactagt tagattcact ttgacacttt tcatatcatt tcttaaccca   4020

agtgacgaaa acattgtccc caatgaatat actcattaga attaccattt gttaatatca   4080

ctcattaatt aaccccataa ttagatccat taatttaaat gatttaaatt taagtaagtt   4140

ttataaggtc tgacatcaga ggtatcttac tttcctctga ggatgatgta cttgccctga   4200

ccatgcattt taccatcaca catgttcaga aagggccaaa ttcccaacct gctcattttt   4260

tttttatcag agtcatgatg aatcagtcct agaatgtttc atttgcacaa gtagggctgc   4320

ctccaagagg aacctctgat ttattttgta tgaaatatat gtgaaaggat atgaatctga   4380

gagatgctgt agacatctgt cctacacttg agatgatttc caagcctctc tggcactttg   4440

agttaagtct atctggtatt aaatgccaag gaccttttgc tgcctaaatc cactctgcag   4500

gaaataggcc caaccaccag atgagaatta ggccctggat gagtagcgct atagttactg   4560

tcctgttgat taatttctgc catttcatgt ccataaaaga gaccacccat atcatgcaca   4620

caattagatt tctcacactc taactgtata tttgtatgat attttaaaat ctcctaaatg   4680

ctgggcaatg gctattaaca attaattgtc ttgcactggc cttctgatga aatgttaaca   4740

atgcctattg taatatagaa aaaaacattc tatctactga tttgggctga atgtatgtaa   4800

ataggtttct aaaaagtcag atgtttgagc agtggcctac aaatcagtaa ttttcggatg   4860

ggagagtttc tttacattgc cgtggcatct taaaagctat cttcatgtaa attgactgta   4920

ctaggcctac tggggatcag agttcccaag aaaggaaacc ttttcttgta tctggattca   4980

aatttatttc caatgtttca agcgggaaac atgactcttt attgtctgta aatctaacat   5040

tattactttt cctcttagaa gaatattgta ttgttagatg tttgttgagc tggtaacatc   5100

gttgcaacca ctgcaatatc ttcgttagta atctgtataa tactttgtat acaagtactg   5160

gtaagattgt tattaaatgt agcttcagtc attaaattac tatagcaaag tagtacttct   5220

tctgtaatat ttacaatgta ttaagcccac agtatatttt atttcaatgt aattaaactg   5280

ttaacttatt caaagagaaa acatctcatc atgtctattg tccaaagtta cctggaatca   5340

aataaaaatt ctagattacc atgaagaaca taaaaaaaaa aaaaaaa                 5387


<210>  4
<211>  439
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(439)
<223>  Amino acid sequence of human cannabinoid receptor 2

<400>  4

Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile 
1               5                   10                  15      


Thr Thr Asp Leu Leu Gly Ser Pro Phe Gln Glu Lys Met Thr Ala Gly 
            20                  25                  30          


Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu Phe 
        35                  40                  45              


Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile Gln 
    50                  55                  60                  


Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn Pro 
65                  70                  75                  80  


Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr Phe 
                85                  90                  95      


Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser Arg 
            100                 105                 110         


Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala Val 
        115                 120                 125             


Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp Phe 
    130                 135                 140                 


His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys Leu 
145                 150                 155                 160 


Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe Leu 
                165                 170                 175     


Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr Lys 
            180                 185                 190         


Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met Trp 
        195                 200                 205             


Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn Cys 
    210                 215                 220                 


Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp Glu 
225                 230                 235                 240 


Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu Phe 
                245                 250                 255     


Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His Ala 
            260                 265                 270         


Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His Thr 
        275                 280                 285             


Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg Met 
    290                 295                 300                 


Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu Ile 
305                 310                 315                 320 


Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe Gly 
                325                 330                 335     


Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met Leu 
            340                 345                 350         


Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg Ser 
        355                 360                 365             


Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu Gly 
    370                 375                 380                 


Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu His 
385                 390                 395                 400 


Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser Cys 
                405                 410                 415     


Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser Thr 
            420                 425                 430         


Asp Thr Ser Ala Glu Ala Leu 
        435                 


<210>  5
<211>  4959
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(4959)
<223>  Nucleotide sequence of human opioid receptor k1

<400>  5
agtgggagac gtgcgctgag aggcgggggc tgcgctcggc ggaacagcag ccctcgggcg     60

gagagcgggg ccggggtccg agagcaggtg atgccaagag ctgagcggga ctcgtgagcg    120

cgcggttcag cacctaccag ggcgtcccgt aaaaaacctc gccttcgcct gtctctggga    180

accatagcgc cgcaggtgcc gcctgtcctc gccttcctgc tgcaatcgcc ccaccatgga    240

ctccccgatc cagatcttcc gcggggagcc gggccctacc tgcgccccga gcgcctgcct    300

gccccccaac agcagcgcct ggtttcccgg ctgggccgag cccgacagca acggcagcgc    360

cggctcggag gacgcgcagc tggagcccgc gcacatctcc ccggccatcc cggtcatcat    420

cacggcggtc tactccgtag tgttcgtcgt gggcttggtg ggcaactcgc tggtcatgtt    480

cgtgatcatc cgatacacaa agatgaagac agcaaccaac atttacatat ttaacctggc    540

tttggcagat gctttagtta ctacaaccat gccctttcag agtacggtct acttgatgaa    600

ttcctggcct tttggggatg tgctgtgcaa gatagtaatt tccattgatt actacaacat    660

gttcaccagc atcttcacct tgaccatgat gagcgtggac cgctacattg ccgtgtgcca    720

ccccgtgaag gctttggact tccgcacacc cttgaaggca aagatcatca atatctgcat    780

ctggctgctg tcgtcatctg ttggcatctc tgcaatagtc cttggaggca ccaaagtcag    840

ggaagacgtc gatgtcattg agtgctcctt gcagttccca gatgatgact actcctggtg    900

ggacctcttc atgaagatct gcgtcttcat ctttgccttc gtgatccctg tcctcatcat    960

catcgtctgc tacaccctga tgatcctgcg tctcaagagc gtccggctcc tttctggctc   1020

ccgagagaaa gatcgcaacc tgcgtaggat caccagactg gtcctggtgg tggtggcagt   1080

cttcgtcgtc tgctggactc ccattcacat attcatcctg gtggaggctc tggggagcac   1140

ctcccacagc acagctgctc tctccagcta ttacttctgc atcgccttag gctataccaa   1200

cagtagcctg aatcccattc tctacgcctt tcttgatgaa aacttcaagc ggtgtttccg   1260

ggacttctgc tttccactga agatgaggat ggagcggcag agcactagca gagtccgaaa   1320

tacagttcag gatcctgctt acctgaggga catcgatggg atgaataaac cagtatgact   1380

agtcgtggag atgtcttcgt acagttcttc gggaagagag gagttcaatg atctaggttt   1440

aactcagatc actactgcag tctgacatga aaagatagaa tttaaaataa acttttagag   1500

atctcatggt ctgaagtcat cagatgcaga ccacgttcgt gatcagtgga aacatcaagg   1560

acaaaaggtc cacgcaacac atgcacctct tctctagggc acagaagcga ggcagagcct   1620

cagttcctct gatgaacaag ggaacaggtc ttttccttct ggtttgctag gtaaggttca   1680

gcacccatct gctgtggcct tcctatgaaa cgtagtttca aaagctcggt ttaagaaaaa   1740

aggaaaagaa aaaacattgc tttcagagct caatgggcat ccaatccaga tgtttcacaa   1800

tgacagcaac aacctccaac ggaatgggaa ctatttccag ggttcatgcc cagctcactg   1860

tatgctgtgt ggacatgcat ttcatgtggc tgtgtggtaa gaattacagc ttacatatgg   1920

cttggaccca catctgagga atctgatgtt cacttatacc agaacattat cttgctattt   1980

atgaaattat ttaaacgttc aaaagattgt ttttaacatg gtttaatttc ccaaaaacta   2040

cagttttttt tcttagcatg ctattcaggt aaacagtctt ataataaagc atgtcccatt   2100

gtcaagaaac ataaagtggt gtgaatacca ctgaaaatat atatatagta tcttctgtaa   2160

ataatagtac ctgtgtgaat aaggaatagg cttgcctccc agccaggcaa tttcctgagg   2220

gcacactaat gatatcccct gagttgctaa gttgatgctg agacattttg ctgggaatta   2280

gtcatggcat gatctctttc agactccctg aataccattt agtcccgtaa cagtgctcac   2340

aactcatgtg ctaatgaatc acaaaggctt taactagctc ccaggttgta gccttcgcag   2400

gatctagttt atttgccaca tctctttatg aacatatagc gattcgcaga tctctctatt   2460

cacggagagg aaggtgtttt gcttctgtag atctcaaggt actattttgt ggctctcagc   2520

aggaagtaga attgttccta aatgtgtgct gaatgaggac atgatgtccc tcctggtgcc   2580

aggacacatc ctgcatggca ttctgtgaag ggcatacctg ctgaggataa tgccaggagc   2640

agcacattta gggtaatttt gctaaaactt ccagatgaca tataaattcc ctctttttcc   2700

ccctgaaact taccatttca gaggtaatgg ctttttctgt aatttgcctg agaagaaaaa   2760

agggataatt tagaaataac actccaagcc tatatattac tagggctgca tcctctggaa   2820

tttaatagaa aaattgaata tatagcccta tgtaactaca gacatcatta caactgttaa   2880

gttctgttca ccatgcaagt tctcggtggt gtatgtactc tcaccttttg gaaacaaaac   2940

cttgcattga aggttttaca catggcttca gaatgttact ctgaccatgt ttgcctctac   3000

tccagattat catggcacct aacacagatg acatatggca gaatggaagt gatttctcct   3060

aatgaaaatg aagtgctctt ttgagtattt cttgttttat tgagattcct atctgccctt   3120

gtatttttat aactgaatgt aaataggaat tgcttaaata ctggtttaca ctaatcccat   3180

agttaaaaat cttggctatg gtacaggaag gatatctata tagaggatag ttccagaaac   3240

aagccctggt gaaataggaa atataaaaac ttctttatgg aacaggaaaa cccaagagac   3300

tttctcgtca gattcctttc cagtgcaaag tataacagag ataggattat gagatgaaat   3360

cacagtagtg tgtttccttt aattttttct gtcttctttt tttttttttt tttttttgag   3420

acggagtctc gctctgttgc ccaggctgga gtgcggtagc acagtcttgg ctcactgcaa   3480

cctccacctc ctgggttcaa gcgattctcc tgcctctgcc tcctaagtag ctgggattac   3540

aggcgtgcac cgccaagccc ggctaatttt tgtattttta gtagagacgg ggtttcacca   3600

tgttatgcag gctggtctca aactcctgac ctcagaatat tcacctgcct cggcctccca   3660

aagtgctggg attacagatg tgaatggcca cgcctggcct gtttccttta agttagcact   3720

tcacgtgctc ttacagcgtt aattgccatt attggtttgc ctgattttcc tgcatctcct   3780

catatgtaag tctgcagccc aaggagagaa tagtagctgt atgtgcccac aaggggtgtc   3840

caagcttctt gattcttgtt aatatcgact ccccaacatt gaaaaaggag tgaagaaggg   3900

aatatcattt tagggtactg ctttaaagga atgataaagt aaacaacgta gcagggaaaa   3960

taccacttgc acaaatgtat ttctttgtca aagtgtgtac acgctttctg tttgtcctga   4020

tgtcctgctg tgaagcaggg accacattgc catttattca ttgttccagg caatgcattt   4080

gtccaaaccc ctctggctct ctgatatctc tcatttcttg atgttcctat tctctgacct   4140

caacaaggag gacactgtct gttgtgtctc tttgagacta gaactccatg tgtttaacct   4200

tcagatccat tctctacatg aaccctattc tttccaccct ggtaagaagg tctggaagac   4260

aggtcctaac gaggggtcag agaaggcaca gagaaatgaa ccagccatgc aggggcagca   4320

ctgaggagga aaccccccac tctaactggg aggagagtgg aaacactctt agtatctcag   4380

agtagttacc aatctaagag catccttcga gtttaagtca aaactctagg cttaatacca   4440

aaaataatac atcatttgga aaaatagctt ggagaaaaaa aatcaataaa gagtcacata   4500

aaatcttaag aaaatggttc tattctgtga tatattacta agaaatacag ttcttaaacg   4560

tgtataacta ttgtcagaca atttataggt gtttcatcta gtcctgggat gaaatacgat   4620

gactcatgca aattcaggga gcacactggc tgactttaaa ttggaacatt gtaaagtgaa   4680

agctgtgaaa ggttgtgtgt cctatcaatg agatttattt tctaaccaag agctgttcgg   4740

atgattcagt ataaatacga aaatcacatc caaaaacggt ataacccagc ttccttaagg   4800

caattttctt ctctgaaaca agaatatact catatgttct ttactataat gtatatgatt   4860

tttatcttgt actttaaaag atgataatta tgcattgtat atacgattgt gtgccttgca   4920

ataaaatcaa aactgtacct gctgaaaatc acaacagtc                          4959


<210>  6
<211>  380
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(380)
<223>  Amino acid sequence of human opioid receptor k1

<400>  6

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Val Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Thr Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Glu Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210>  7
<211>  2178
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2178)
<223>  Nucleotide sequence of human opioid receptor 1; transcript 
       variant MOR-1

<400>  7
gatgagcctc tgtgaactac taaggtggga gggggctata cgcagaggag aatgtcagat     60

gctcagctcg gtcccctccg cctgacgctc ctctctgtct cagccaggac tggtttctgt    120

aagaaacagc aggagctgtg gcagcggcga aaggaagcgg ctgaggcgct tggaacccga    180

aaagtctcgg tgctcctggc tacctcgcac agcggtgccc gcccggccgt cagtaccatg    240

gacagcagcg ctgcccccac gaacgccagc aattgcactg atgccttggc gtactcaagt    300

tgctccccag cacccagccc cggttcctgg gtcaacttgt cccacttaga tggcaacctg    360

tccgacccat gcggtccgaa ccgcaccgac ctgggcggga gagacagcct gtgccctccg    420

accggcagtc cctccatgat cacggccatc acgatcatgg ccctctactc catcgtgtgc    480

gtggtggggc tcttcggaaa cttcctggtc atgtatgtga ttgtcagata caccaagatg    540

aagactgcca ccaacatcta cattttcaac cttgctctgg cagatgcctt agccaccagt    600

accctgccct tccagagtgt gaattaccta atgggaacat ggccatttgg aaccatcctt    660

tgcaagatag tgatctccat agattactat aacatgttca ccagcatatt caccctctgc    720

accatgagtg ttgatcgata cattgcagtc tgccaccctg tcaaggcctt agatttccgt    780

actccccgaa atgccaaaat tatcaatgtc tgcaactgga tcctctcttc agccattggt    840

cttcctgtaa tgttcatggc tacaacaaaa tacaggcaag gttccataga ttgtacacta    900

acattctctc atccaacctg gtactgggaa aacctgctga agatctgtgt tttcatcttc    960

gccttcatta tgccagtgct catcattacc gtgtgctatg gactgatgat cttgcgcctc   1020

aagagtgtcc gcatgctctc tggctccaaa gaaaaggaca ggaatcttcg aaggatcacc   1080

aggatggtgc tggtggtggt ggctgtgttc atcgtctgct ggactcccat tcacatttac   1140

gtcatcatta aagccttggt tacaatccca gaaactacgt tccagactgt ttcttggcac   1200

ttctgcattg ctctaggtta cacaaacagc tgcctcaacc cagtccttta tgcatttctg   1260

gatgaaaact tcaaacgatg cttcagagag ttctgtatcc caacctcttc caacattgag   1320

caacaaaact ccactcgaat tcgtcagaac actagagacc acccctccac ggccaataca   1380

gtggatagaa ctaatcatca gctagaaaat ctggaagcag aaactgctcc gttgccctaa   1440

cagggtctca tgccattccg accttcacca agcttagaag ccaccatgta tgtggaagca   1500

ggttgcttca agaatgtgta ggaggctcta attctctagg aaagtgcctg cttttaggtc   1560

atccaacctc tttcctctct ggccactctg ctctgcacat tagagggaca gccaaaagta   1620

agtggagcat ttggaaggaa aggaatatac cacaccgagg agtccagttt gtgcaagaca   1680

cccagtggaa ccaaaaccca tcgtggtatg tgaattgaag tcatcataaa aggtgaccct   1740

tctgtctgta agattttatt ttcaagcaaa tatttatgac ctcaacaaag aagaaccatc   1800

ttttgttaag ttcaccgtag taacacataa agtaaatgct acctctgatc aaagcacctt   1860

gaatggaagg tccgagtctt tttagtgttt tgcaagggaa tgaatccatt attctatttt   1920

agacttttaa cttcacctta aaattagcat ctggctaagg catcattttc acctccattt   1980

cttggttttg tattgtttaa aaaaataaca tctctttcat ctagctccat aattgcaagg   2040

gaagagatta gcatgaaagg taatctgaaa cacagtcatg tgtcagctgt agaaaggttg   2100

attctcatgc actgcaaata cttccaaaga gtcatcatgg gggatttttc attcttaggc   2160

tttcagtggt ttgttcct                                                 2178


<210>  8
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(400)
<223>  Amino acid sequence of human opioid receptor 1; transcript 
       variant MOR-1

<400>  8

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Leu Glu Asn Leu Glu Ala Glu Thr Ala Pro Leu Pro 
385                 390                 395                 400 


