                         SEQUENCE LISTING

<110>  DiaMedica Inc.
       Pauls, Dietrich J.
       Kolodka, Tadeusz M.
       Williams, Mark
 
<120>  COMBINATION OF AN INSULIN AND TISSUE KALLIKREIN 1

<130>  474.00010201

<150>  US 61/714,150
<151>  2012-10-15

<150>  US 61/799,806
<151>  2013-03-15

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  262
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(18)

<220>
<221>  PROPEP
<222>  (19)..(24)

<220>
<221>  mat_peptide
<222>  (25)..(262)

<400>  1

Met Trp Phe Leu Val Leu Cys Leu Ala Leu Ser Leu Gly Gly Thr Gly 
                -20                 -15                 -10     


Ala Ala Pro Pro Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            -5              -1  1               5               


Gln His Ser Gln Pro Trp Gln Ala Ala Leu Tyr His Phe Ser Thr Phe 
    10                  15                  20                  


Gln Cys Gly Gly Ile Leu Val His Arg Gln Trp Val Leu Thr Ala Ala 
25                  30                  35                  40  


His Cys Ile Ser Asp Asn Tyr Gln Leu Trp Leu Gly Arg His Asn Leu 
                45                  50                  55      


Phe Asp Asp Glu Asn Thr Ala Gln Phe Val His Val Ser Glu Ser Phe 
            60                  65                  70          


Pro His Pro Gly Phe Asn Met Ser Leu Leu Glu Asn His Thr Arg Gln 
        75                  80                  85              


Ala Asp Glu Asp Tyr Ser His Asp Leu Met Leu Leu Arg Leu Thr Glu 
    90                  95                  100                 


Pro Ala Asp Thr Ile Thr Asp Ala Val Lys Val Val Glu Leu Pro Thr 
105                 110                 115                 120 


Glu Glu Pro Glu Val Gly Ser Thr Cys Leu Ala Ser Gly Trp Gly Ser 
                125                 130                 135     


Ile Glu Pro Glu Asn Phe Ser Phe Pro Asp Asp Leu Gln Cys Val Asp 
            140                 145                 150         


Leu Lys Ile Leu Pro Asn Asp Glu Cys Lys Lys Ala His Val Gln Lys 
        155                 160                 165             


Val Thr Asp Phe Met Leu Cys Val Gly His Leu Glu Gly Gly Lys Asp 
    170                 175                 180                 


Thr Cys Val Gly Asp Ser Gly Gly Pro Leu Met Cys Asp Gly Val Leu 
185                 190                 195                 200 


Gln Gly Val Thr Ser Trp Gly Tyr Val Pro Cys Gly Thr Pro Asn Lys 
                205                 210                 215     


Pro Ser Val Ala Val Arg Val Leu Ser Tyr Val Lys Trp Ile Glu Asp 
            220                 225                 230         


Thr Ile Ala Glu Asn Ser 
        235             


<210>  2
<211>  262
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(18)

<220>
<221>  PROPEP
<222>  (19)..(24)

<220>
<221>  mat_peptide
<222>  (25)..(262)

<400>  2

Met Trp Phe Leu Val Leu Cys Leu Ala Leu Ser Leu Gly Gly Thr Gly 
                -20                 -15                 -10     


Ala Ala Pro Pro Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            -5              -1  1               5               


Gln His Ser Gln Pro Trp Gln Ala Ala Leu Tyr His Phe Ser Thr Phe 
    10                  15                  20                  


Gln Cys Gly Gly Ile Leu Val His Arg Gln Trp Val Leu Thr Ala Ala 
25                  30                  35                  40  


His Cys Ile Ser Asp Asn Tyr Gln Leu Trp Leu Gly Arg His Asn Leu 
                45                  50                  55      


Phe Asp Asp Glu Asn Thr Ala Gln Phe Val His Val Ser Glu Ser Phe 
            60                  65                  70          


Pro His Pro Gly Phe Asn Met Ser Leu Leu Glu Asn His Thr Arg Gln 
        75                  80                  85              


Ala Asp Glu Asp Tyr Ser His Asp Leu Met Leu Leu Arg Leu Thr Glu 
    90                  95                  100                 


Pro Ala Asp Thr Ile Thr Asp Ala Val Lys Val Val Glu Leu Pro Thr 
105                 110                 115                 120 


Gln Glu Pro Glu Val Gly Ser Thr Cys Leu Ala Ser Gly Trp Gly Ser 
                125                 130                 135     


Ile Glu Pro Glu Asn Phe Ser Phe Pro Asp Asp Leu Gln Cys Val Asp 
            140                 145                 150         


Leu Lys Ile Leu Pro Asn Asp Glu Cys Lys Lys Val His Val Gln Lys 
        155                 160                 165             


Val Thr Asp Phe Met Leu Cys Val Gly His Leu Glu Gly Gly Lys Asp 
    170                 175                 180                 


Thr Cys Val Gly Asp Ser Gly Gly Pro Leu Met Cys Asp Gly Val Leu 
185                 190                 195                 200 


Gln Gly Val Thr Ser Trp Gly Tyr Val Pro Cys Gly Thr Pro Asn Lys 
                205                 210                 215     


Pro Ser Val Ala Val Arg Val Leu Ser Tyr Val Lys Trp Ile Glu Asp 
            220                 225                 230         


Thr Ile Ala Glu Asn Ser 
        235             


