                               SEQUENCE LISTING

<110> ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF 
      ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
 
<120> ANTIBODY BASED REAGENTS THAT SPECIFICALLY RECOGNIZE TOXIC 
      OLIGOMERIC FORMS OF TAU

<130> 17555.018WO1

<140> PCT/US2013/065104
<141> 2013-10-15

<150> 61/713,441
<151> 2012-10-12

<160> 50    

<170> PatentIn version 3.5

<210> 1
<211> 300
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (297)..(300)
<223> Any amino acid

<400> 1
Xaa Glu Xaa Val Ile Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Gln Val Gln Leu Gln 
            20                  25                  30          


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
        35                  40                  45              


Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser Gly Met His Trp Val 
    50                  55                  60                  


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Phe Ile Leu His 
65                  70                  75                  80  


Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                85                  90                  95      


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
            100                 105                 110         


Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Lys Ser Gln Arg 
        115                 120                 125             


Glu Leu Leu Gly Ala Glu Tyr Leu Gln Asn Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
                165                 170                 175     


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
            180                 185                 190         


Val Gly Gly Tyr Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
        195                 200                 205             


Ala Pro Lys Val Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val 
    210                 215                 220                 


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
225                 230                 235                 240 


Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
                245                 250                 255     


Tyr Thr Ser Ser Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Val Thr 
            260                 265                 270         


Val Leu Gly Ala Ala Ala His His His His His His Gly Ala Ala Glu 
        275                 280                 285             


Gln Lys Leu Ile Ser Glu Glu Asp Xaa Xaa Xaa Xaa 
    290                 295                 300 


<210> 2
<211> 991
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (888)..(888)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (902)..(902)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (907)..(907)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (911)..(913)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (920)..(921)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (945)..(945)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (948)..(948)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (951)..(951)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (962)..(963)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (971)..(971)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (977)..(977)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (979)..(983)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (989)..(989)
<223> a, c, t, g, unknown or other

<400> 2
aattctattt cnggagacag tcataatgaa atacctattg cctacggcag ccgctggatt       60

gttattactc gcggcccagc cggccatggc ccaggtgcag ctgcaggagt cgggggaggc      120

gtggtccagc ctgggaggtc cctgagactc tcctgtgcag cgtctggatt caccttcagt      180

acttctggca tgcactgggt ccgccaggct ccaggcaagg ggctggagtg ggtggcattt      240

atactacatg atggaagtga taaatactat gcagactccg tgaagggccg attcaccatc      300

tccagagaca attccaagaa cacgctgtat ctgcaaatga acagcctgag agccgaggac      360

acggccatat attactgtgc gaaatctcag agggagctac tcggcgctga atacctccag      420

aactggggcc agggcaccct ggtcaccgtc tcctcaggtg gaggcggttc aggcggaggt      480

ggctctggcg gtggcggatc gcagtctgct ctgactcagc ctgcctccgt gtctgggtct      540

cctggacagt cgatcaccat ctcctgcact ggaaccagca gtgacgttgg tggttataag      600

tatgtctcct ggtaccaaca gcacccaggc aaagccccca aagtcatgat ttatgatgtc      660

agtaatcggc cctcaggggt ttctaatcgc ttctctggct ccaagtctgg caacacggcc      720

tccctgacca tctctgggct ccaggctgag gacgaggctg attattactg cagctcatat      780

acaagcagca gcactctcgt gttcggcggc gggaccaagg tcaccgtcct aggtgcggcc      840

gcagaacaaa aactcatctc agaagaggat ctgaatgggg ccgcatanac tgttgaaagt      900

tntttancaa nnntcatacn naaaattcat ttactaacgt ctggnaanac nacaaaactt      960

tnnatcgtta ngctaantnn nnnagggcng t                                     991


<210> 3
<211> 902
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (892)..(893)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (896)..(900)
<223> a, c, t, g, unknown or other

<400> 3
ttcnngagan agtcataatg aaatacctat tgcctacggc agccgctgga ttgttattac       60

tcgcggccca gccggccatg gcccaggtgc agctgcagga gtctggggga ggcgtggtcc      120

agcctgggag gtccctgaga ctctcctgtg cagcgtctgg attcaccttc agtacttctg      180

gcatgcactg ggtccgccag gctccaggca aggggctgga gtgggtggca tttatactac      240

atgatggaag tgataaatac tatgcagact ccgtgaaggg ccgattcacc atctccagag      300

acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagccgag gacacggcca      360

tatattactg tgcgaaatct cagagggagc tactcggcgc tgaatacctc cagaactggg      420

gccagggcac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga ggtggctctg      480

gcggtggcgg atcgcagtct gctctgactc agcctgcctc cgtgtctggg tctcctggac      540

agtcgatcac catctcctgc actggaacca gcagtgacgt tggtggttat aagtatgtct      600

cctggtacca acagcaccca ggcaaagccc ccaaagtcat gatttatgat gtcagtaatc      660

ggccctcagg ggtttctaat cgcttctctg gctccaagtc tggcaacacg gcctccctga      720

ccatctctgg gctccaggct gaggacgagg ctgattatta ctgcagctca tatacaagca      780

gcagcactct cgtgttcggc ggcgggacca aggtcaccgt cctaggtgcg gccgcacatc      840

atcatcacca tcacggggcc gcagaacaaa aactcatctc agaagaggat cnnaannnnn      900

cg                                                                     902


<210> 4
<211> 902
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (892)..(893)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (896)..(900)
<223> a, c, t, g, unknown or other

<400> 4
ttcnngagan agtcataatg aaatacctat tgcctacggc agccgctgga ttgttattac       60

tcgcggccca gccggccatg gcccaggtgc agctgcagga gtctggggga ggcgtggtcc      120

agcctgggag gtccctgaga ctctcctgtg cagcgtctgg attcaccttc agtacttctg      180

gcatgcactg ggtccgccag gctccaggca aggggctgga gtgggtggca tttatactac      240

atgatggaag tgataaatac tatgcagact ccgtgaaggg ccgattcacc atctccagag      300

acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagccgag gacacggcca      360

tatattactg tgcgaaatct cagagggagc tactcggcgc tgaatacctc cagaactggg      420

gccagggcac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga ggtggctctg      480

gcggtggcgg atcgcagtct gctctgactc agcctgcctc cgtgtctggg tctcctggac      540

agtcgatcac catctcctgc actggaacca gcagtgacgt tggtggttat aagtatgtct      600

cctggtacca acagcaccca ggcaaagccc ccaaagtcat gatttatgat gtcagtaatc      660

ggccctcagg ggtttctaat cgcttctctg gctccaagtc tggcaacacg gcctccctga      720

ccatctctgg gctccaggct gaggacgagg ctgattatta ctgcagctca tatacaagca      780

gcagcactct cgtgttcggc ggcgggacca aggtcaccgt cctaggtgcg gccgcacatc      840

atcatcacca tcacggggcc gcagaacaaa aactcatctc agaagaggat cnnaannnnn      900

cg                                                                     902


<210> 5
<211> 991
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (888)..(888)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (902)..(902)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (907)..(907)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (911)..(913)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (920)..(921)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (945)..(945)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (948)..(948)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (951)..(951)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (962)..(963)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (971)..(971)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (977)..(977)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (979)..(983)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (989)..(989)
<223> a, c, t, g, unknown or other

<400> 5
aattctattt cnggagacag tcataatgaa atacctattg cctacggcag ccgctggatt       60

gttattactc gcggcccagc cggccatggc ccaggtgcag ctgcaggagt cgggggaggc      120

gtggtccagc ctgggaggtc cctgagactc tcctgtgcag cgtctggatt caccttcagt      180

acttctggca tgcactgggt ccgccaggct ccaggcaagg ggctggagtg ggtggcattt      240

atactacatg atggaagtga taaatactat gcagactccg tgaagggccg attcaccatc      300

tccagagaca attccaagaa cacgctgtat ctgcaaatga acagcctgag agccgaggac      360

acggccatat attactgtgc gaaatctcag agggagctac tcggcgctga atacctccag      420

aactggggcc agggcaccct ggtcaccgtc tcctcaggtg gaggcggttc aggcggaggt      480

ggctctggcg gtggcggatc gcagtctgct ctgactcagc ctgcctccgt gtctgggtct      540

cctggacagt cgatcaccat ctcctgcact ggaaccagca gtgacgttgg tggttataag      600

tatgtctcct ggtaccaaca gcacccaggc aaagccccca aagtcatgat ttatgatgtc      660

agtaatcggc cctcaggggt ttctaatcgc ttctctggct ccaagtctgg caacacggcc      720

tccctgacca tctctgggct ccaggctgag gacgaggctg attattactg cagctcatat      780

acaagcagca gcactctcgt gttcggcggc gggaccaagg tcaccgtcct aggtgcggcc      840

gcagaacaaa aactcatctc agaagaggat ctgaatgggg ccgcatanac tgttgaaagt      900

tntttancaa nnntcatacn naaaattcat ttactaacgt ctggnaanac nacaaaactt      960

tnnatcgtta ngctaantnn nnnagggcng t                                     991


<210> 6
<211> 1002
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (743)..(743)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (799)..(800)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (824)..(826)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (862)..(862)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (878)..(879)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (881)..(881)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (900)..(900)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (903)..(903)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (908)..(908)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (921)..(921)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (931)..(931)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (935)..(936)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (965)..(969)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (977)..(977)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (980)..(980)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (985)..(988)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (992)..(992)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (996)..(1000)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1002)..(1002)
<223> a, c, t, g, unknown or other

<400> 6
ttcnngagan agtcataatg aaatacctat tgcctacggc agccgctgga ttgttattac       60

tcgcggccca gccggccatg gcccaggtgc agctgcagga gtctggggga ggcgtggtcc      120

agcctgggag gtccctgaga ctctcctgtg cagcgtctgg attcaccttc agtacttctg      180

gcatgcactg ggtccgccag gctccaggca aggggctgga gtgggtggca tttatactac      240

atgatggaag tgataaatac tatgcagact ccgtgaaggg ccgattcacc atctccagag      300

acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagccgag gacacggcca      360

tatattactg tgcgaaatct cagagggagc tactcggcgc tgaatacctc cagaactggg      420

gccagggcac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga ggtggctctg      480

gcggtggcgg atcgcagtct gctctgactc agcctgcctc cgtgtctggg tctcctggac      540

agtcgatcac catctcctgc actggaacca gcagtgacgt tggtggttat aagtatgtct      600

cctggtacca acagcaccca ggcaaagccc ccaaagtcat gatttatgat gtcagtaatc      660

ggccctcagg ggtttctaat cgcttctctg gctccaagtc tggcaacacg gcctccctga      720

ccatctctgg gctccaggct gangacgagg ctgattatta ctgcagctca tatacaagca      780

gcagcactct cgtgttcgnn ggcgggacca aggtcaccgt cctnnngcgg ccgcacatca      840

tcatcaccat cacggggccg cngacaaaac tcatctcnna naggatctga atgggccgcn      900

tanactgntg aaagttgtta ncaaaacctc ntacnnaaaa ttcatttact aacgtctgga      960

aagannnnna actttanatn gttannnnaa cnatgnnnnn gn                        1002


<210> 7
<211> 991
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (2)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (24)..(29)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (35)..(36)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (38)..(38)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (58)..(58)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (85)..(85)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (116)..(116)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (123)..(123)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (127)..(129)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (132)..(133)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (135)..(137)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (142)..(143)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (206)..(206)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (222)..(222)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (224)..(225)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (981)..(982)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (985)..(989)
<223> a, c, t, g, unknown or other

<400> 7
gnnnnntnnn nggaantgng agcnnnnnna atttnncnca ggaaacagct atgaccanga       60

ttacgccaag cttgcatgca aattntattt caaggagaca gtcataatga aatacntatt      120

gcntacnnnc anncnnngga tnntattact cgcggcccag ccggccatgg cccaggtgca      180

gctgcaggag tctgggggag gcgtgntcca gcctgggagg tncnngagac tctcctgtgc      240

agcgtctgga ttcaccttca gtacttctgg catgcactgg gtccgccagg ctccaggcaa      300

ggggctggag tgggtggcat ttatactaca tgatggaagt gataaatact atgcagactc      360

cgtgaagggc cgattcacca tctccagaga caattccaag aacacgctgt atctgcaaat      420

gaacagcctg agagccgagg acacggccat atattactgt gcgaaatctc agagggagct      480

actcggcgct gaatacctcc agaactgggg ccagggcacc ctggtcaccg tctcctcagg      540

tggaggcggt tcaggcggag gtggctctgg cggtggcgga tcgcagtctg ctctgactca      600

gcctgcctcc gtgtctgggt ctcctggaca gtcgatcacc atctcctgca ctggaaccag      660

cagtgacgtt ggtggttata agtatgtctc ctggtaccaa cagcacccag gcaaagcccc      720

caaagtcatg atttatgatg tcagtaatcg gccctcaggg gtttctaatc gcttctctgg      780

ctccaagtct ggcaacacgg cctccctgac catctctggg ctccaggctg aggacgaggc      840

tgattattac tgcagctcat atacaagcag cagcactctc gtgttcggcg gcgggaccaa      900

ggtcaccgtc ctaggtgcgg ccgcacatca tcatcaccat cacggggccg cagaacaaaa      960

actcatctca gaagaggatc nnaannnnnc g                                     991


<210> 8
<211> 992
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (889)..(889)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (903)..(903)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (908)..(908)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (912)..(914)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (921)..(922)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (946)..(946)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (949)..(949)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (952)..(952)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (963)..(964)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (972)..(972)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (978)..(978)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (980)..(984)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (990)..(990)
<223> a, c, t, g, unknown or other

<400> 8
aattctattt cnggagacag tcataatgaa atacctattg cctacggcag ccgctggatt       60

gttattactc gcggcccagc cggccatggc ccaggtgcag ctgcaggagt ctgggggagg      120

cgtggtccag cctgggaggt ccctgagact ctcctgtgca gcgtctggat tcaccttcag      180

tacttctggc atgcactggg tccgccaggc tccaggcaag gggctggagt gggtggcatt      240

tatactacat gatggaagtg ataaatacta tgcagactcc gtgaagggcc gattcaccat      300

ctccagagac aattccaaga acacgctgta tctgcaaatg aacagcctga gagccgagga      360

cacggccata tattactgtg cgaaatctca gagggagcta ctcggcgctg aatacctcca      420

gaactggggc cagggcaccc tggtcaccgt ctcctcaggt ggaggcggtt caggcggagg      480

tggctctggc ggtggcggat cgcagtctgc tctgactcag cctgcctccg tgtctgggtc      540

tcctggacag tcgatcacca tctcctgcac tggaaccagc agtgacgttg gtggttataa      600

gtatgtctcc tggtaccaac agcacccagg caaagccccc aaagtcatga tttatgatgt      660

cagtaatcgg ccctcagggg tttctaatcg cttctctggc tccaagtctg gcaacacggc      720

ctccctgacc atctctgggc tccaggctga ggacgaggct gattattact gcagctcata      780

tacaagcagc agcactctcg tgttcggcgg cgggaccaag gtcaccgtcc taggtgcggc      840

cgcagaacaa aaactcatct cagaagagga tctgaatggg gccgcatana ctgttgaaag      900

ttntttanca annntcatac nnaaaattca tttactaacg tctggnaana cnacaaaact      960

ttnnatcgtt angctaantn nnnnagggcn gt                                    992


<210> 9
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (303)..(305)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (315)..(317)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (326)..(328)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Any amino acid

<400> 9
Ile Leu Phe Xaa Glu Thr Val Ile Met Lys Tyr Leu Leu Pro Thr Ala 
1               5                   10                  15      


Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Gln Val 
            20                  25                  30          


Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
        35                  40                  45              


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser Gly Met 
    50                  55                  60                  


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Phe 
65                  70                  75                  80  


Ile Leu His Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys Gly 
                85                  90                  95      


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
            100                 105                 110         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
        115                 120                 125             


Ser Gln Arg Glu Leu Leu Gly Ala Glu Tyr Leu Gln Asn Trp Gly Gln 
    130                 135                 140                 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser 
                165                 170                 175     


Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr 
            180                 185                 190         


Ser Ser Asp Val Gly Gly Tyr Lys Tyr Val Ser Trp Tyr Gln Gln His 
        195                 200                 205             


Pro Gly Lys Ala Pro Lys Val Met Ile Tyr Asp Val Ser Asn Arg Pro 
    210                 215                 220                 


Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala 
225                 230                 235                 240 


Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
                245                 250                 255     


Cys Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val Phe Gly Gly Gly Thr 
            260                 265                 270         


Lys Val Thr Val Leu Gly Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        275                 280                 285             


Glu Asp Leu Asn Gly Ala Ala Xaa Thr Val Glu Ser Xaa Leu Xaa Xaa 
    290                 295                 300                 


Xaa Ile Xaa Lys Ile His Leu Leu Thr Ser Xaa Xaa Xaa Thr Lys Leu 
305                 310                 315                 320 


Xaa Ile Val Xaa Leu Xaa Xaa Xaa Gly Xaa 
                325                 330 


<210> 10
<211> 1033
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (876)..(876)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (895)..(895)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (900)..(901)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (914)..(914)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (917)..(917)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (921)..(922)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (926)..(928)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (934)..(934)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (939)..(939)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (951)..(953)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (958)..(958)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (965)..(968)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (970)..(975)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (985)..(986)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (989)..(990)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (992)..(992)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (996)..(997)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1002)..(1002)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1004)..(1007)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1012)..(1017)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1021)..(1021)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1023)..(1025)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1027)..(1027)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1029)..(1032)
<223> a, c, t, g, unknown or other

<400> 10
gcanttcnat ttnnngagac agtcataatg aaatacctat tgcctacggc agccgctgga       60

ttgttattac tcgcggccca gccggccatg gcccaggtgc agctggtgga gtctggggga      120

ggcttggtac agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttt      180

agcagctatg ccatgagctg ggtccgccag gctccaggga aggggctgga gtgggtctca      240

gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg ccggttcacc      300

atctccagag acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagccgag      360

gacacggctg tatattactg tgcaagaggt ggcgattatg gctcagggga ctactggggc      420

cagggaaccc tggtcaccgt ctcctcaggt ggaggcggtt caggcggagg tggctctggc      480

ggtggcggat cgaattttat gctgactcag gaccctgctg tgtctgtggc cttgggacag      540

acagtcagaa tcacatgcca aggagacagc ctcagaagct attatgcaag ttggtaccag      600

cagaagccag gacaggcccc tctccttgtc atctatggta aaaacatccg gccctcaggg      660

atcccagacc gattctctgg ctccagctca ggaaactcag cttccttgac catcactggg      720

gctcaggcgg aagatgaggc tgactattac tgtcactccc gggacagcag tggtacccat      780

ctaagggtat tcggcggagg gaccaaggtc accgtcctag gtgcggccgc agaacaaaaa      840

ctcatctcag aagaggatct gaatggggcc gcatanactg ttgaaagttg tttancaaan      900

nctcatacag aaanttnatt nnctannntc tggnaagang acaaaacttt nnntcgtnac      960

gctannnntn nnnnntgtct gtganngcnn cnggcnntgt gntnnnnact gnnnnnnaaa     1020

ntnnngntnn nng                                                        1033


<210> 11
<211> 327
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (299)..(301)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (305)..(310)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (312)..(313)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (317)..(318)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (322)..(325)
<223> Any amino acid

<400> 11
Ala Xaa Xaa Phe Xaa Glu Thr Val Ile Met Lys Tyr Leu Leu Pro Thr 
1               5                   10                  15      


Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Gln 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala 
    50                  55                  60                  


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
65                  70                  75                  80  


Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Gly Gly Asp Tyr Gly Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val 
                165                 170                 175     


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
            180                 185                 190         


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu 
        195                 200                 205             


Leu Val Ile Tyr Gly Lys Asn Ile Arg Pro Ser Gly Ile Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Ser Ser Gly Asn Ser Ala Ser Leu Thr Ile Thr Gly 
225                 230                 235                 240 


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys His Ser Arg Asp Ser 
                245                 250                 255     


Ser Gly Thr His Leu Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val 
            260                 265                 270         


Leu Gly Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
        275                 280                 285             


Gly Ala Ala Xaa Thr Val Glu Ser Cys Leu Xaa Xaa Xaa His Thr Glu 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Trp Xaa Xaa Asp Lys Thr Xaa Xaa Arg Xaa 
305                 310                 315                 320 


Ala Xaa Xaa Xaa Xaa Cys Leu 
                325         


<210> 12
<211> 994
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (3)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (876)..(876)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (895)..(895)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (905)..(905)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (908)..(910)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (927)..(927)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (952)..(953)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (971)..(972)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (978)..(978)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (982)..(983)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (985)..(985)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (987)..(987)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (993)..(993)
<223> a, c, t, g, unknown or other

<400> 12
gcnnntctat ttaaggagac agtcataatg aaatacctat tgcctacggc agccgctgga       60

ttgttattac tcgcggccca gccggccatg gcccaggtgc agctggtggc gtctggagga      120

gacttgatcc agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttt      180

aataactatt ggatgacctg ggtccgccag gctccaggga aggggctgga gtgggtggcc      240

aacataaagc aagatggagg tgagaaatac tatgtggact ctgtgaaggg ccgattcacc      300

atctccagag acaacgccaa gacctcactg tatctgcaaa tgaacagcct gagagccgag      360

gacacggccg tgtattattg tgcgaaagag tcgtatagca ctggctggtt tgaccactgg      420

ggccagggaa ccctggtcac cgtctcctca ggtggaggcg gttcaggcgg aggtggctct      480

ggcggtggcg gatcgaattt tatgctgact caggaccctg ctgtgtctgt ggccttggga      540

cagacagtca ggataacatg tcaaggtgac agcctcagaa aatattatac aagttggtac      600

caacagaagc caggacaggc ccctctactt gtcatgtatg cgaaaaataa ccggccctca      660

gggatcccag accgattctc tggctccagc tcaggaaaca cagcttcctt gaccatcact      720

ggggctcagg cggaagatga ggctgactat tactgtgact cccgggacag cagtggtgac      780

cattgggtgt tcggcggagg gaccaagctg accgttctag gtgcggccgc agaacaaaaa      840

ctcatctcag aagaggatct gaatggggcc gcatanactg ttgaaagttg tttancaaaa      900

cctcntannn aaaattcatt tactaangtc tggaaagacg acaaaacttt anntcgttac      960

gctaactatg nnggctgnct gnngnangct acng                                  994


<210> 13
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (302)..(304)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (328)..(329)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Any amino acid

<400> 13
Xaa Xaa Leu Phe Lys Glu Thr Val Ile Met Lys Tyr Leu Leu Pro Thr 
1               5                   10                  15      


Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Gln 
            20                  25                  30          


Val Gln Leu Val Ala Ser Gly Gly Asp Leu Ile Gln Pro Gly Gly Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr Trp 
    50                  55                  60                  


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
65                  70                  75                  80  


Asn Ile Lys Gln Asp Gly Gly Glu Lys Tyr Tyr Val Asp Ser Val Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Ser Leu Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Lys Glu Ser Tyr Ser Thr Gly Trp Phe Asp His Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser 
                165                 170                 175     


Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu 
            180                 185                 190         


Arg Lys Tyr Tyr Thr Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        195                 200                 205             


Leu Leu Val Met Tyr Ala Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr 
225                 230                 235                 240 


Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asp Ser Arg Asp 
                245                 250                 255     


Ser Ser Gly Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            260                 265                 270         


Leu Gly Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
        275                 280                 285             


Gly Ala Ala Xaa Thr Val Glu Ser Cys Leu Xaa Lys Pro Xaa Xaa Xaa 
    290                 295                 300                 


Asn Ser Phe Thr Xaa Val Trp Lys Asp Asp Lys Thr Leu Xaa Arg Tyr 
305                 310                 315                 320 


Ala Asn Tyr Xaa Gly Xaa Leu Xaa Xaa Ala Xaa 
                325                 330     


<210> 14
<211> 981
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (2)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (865)..(865)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (870)..(870)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (884)..(884)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (894)..(894)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (931)..(931)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (941)..(941)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (950)..(950)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (959)..(961)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (964)..(964)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (971)..(971)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (973)..(973)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (975)..(975)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (978)..(978)
<223> a, c, t, g, unknown or other

<400> 14
tnnnnttnnn gagacagtca taatgaaata cctattgcct acggcagccg ctggattgtt       60

attactcgcg gcccagccgg ccatggcccg agtgcagctg gtggagtctg gggctgaggt      120

gacgaagcct ggggcctcag taagggtctc ctgcaaggct tctggataca ccttcagcag      180

atatgatatc aactgggtgc gacaggcctc tggacaaggg cttgagtgga tgggatggat      240

caaccctaac agtggtaaca caggctatgc acagaagttc cagggcagag tcaccatgac      300

caggaatatt tccataacca cggcctacat ggagctgagc agcctgagat ctgaggacac      360

ggccgtatat tactgtgcga gaggccttcc ggagttcgac ccctggggcc agggaaccct      420

ggtcaccgtc tcctcaggtg gaggcggttc aggcggaggt ggctctggcg gtggcggatc      480

gcacgttata ctgactcagg accctgctgt gtctgtggcc ttgggacaga cagtcaggat      540

cacatgccaa ggagacagcc tcagaagcta ttatgcaagc tggtaccagc agaagccagg      600

acaggcccct gtacttgtca tctatggtaa aaacaaccgg ccctcaggga tcccagaccg      660

attctctggc tccagctcag gaaacacagc ttccttgacc atcactgggg ctcaggcgga      720

agatgaggct gacttttact gtaattcccg ggacagcagt ggcacccatc tagaggtgtt      780

cggcggaggg accaaggtca ccgtcctagg tgcggccgca gaacaaaaac tcatctcaga      840

agaggatctg aatggggccg catanactgn tgaaagttgt ttancaaaac ctcntacaga      900

aaattcattt actaacgtct ggaaagacga naaaacttta natcgttacn ctaactatnn      960

nggntgtctg ngnantgnta c                                                981


<210> 15
<211> 327
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (321)..(322)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (325)..(327)
<223> Any amino acid

<400> 15
Ala Xaa Xaa Xaa Glu Thr Val Ile Met Lys Tyr Leu Leu Pro Thr Ala 
1               5                   10                  15      


Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Arg Val 
            20                  25                  30          


Gln Leu Val Glu Ser Gly Ala Glu Val Thr Lys Pro Gly Ala Ser Val 
        35                  40                  45              


Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr Asp Ile 
    50                  55                  60                  


Asn Trp Val Arg Gln Ala Ser Gly Gln Gly Leu Glu Trp Met Gly Trp 
65                  70                  75                  80  


Ile Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln Gly 
                85                  90                  95      


Arg Val Thr Met Thr Arg Asn Ile Ser Ile Thr Thr Ala Tyr Met Glu 
            100                 105                 110         


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        115                 120                 125             


Gly Leu Pro Glu Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser His Val Ile Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
                165                 170                 175     


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 
            180                 185                 190         


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        195                 200                 205             


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
225                 230                 235                 240 


Glu Asp Glu Ala Asp Phe Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr 
                245                 250                 255     


His Leu Glu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Ala 
            260                 265                 270         


Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala 
        275                 280                 285             


Xaa Thr Xaa Glu Ser Cys Leu Xaa Lys Pro Xaa Thr Glu Asn Ser Phe 
    290                 295                 300                 


Thr Asn Val Trp Lys Asp Xaa Lys Thr Leu Xaa Arg Tyr Xaa Asn Tyr 
305                 310                 315                 320 


Xaa Xaa Cys Leu Xaa Xaa Xaa 
                325         


<210> 16
<211> 1041
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (706)..(706)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (746)..(746)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (748)..(748)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (771)..(773)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (796)..(796)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (803)..(803)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (815)..(815)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (833)..(833)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (851)..(851)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (855)..(855)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (857)..(857)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (859)..(860)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (862)..(862)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (875)..(875)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (878)..(878)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (883)..(883)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (900)..(900)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (913)..(913)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (917)..(917)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (925)..(925)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (928)..(931)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (933)..(933)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (935)..(936)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (944)..(944)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (946)..(946)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (948)..(948)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (950)..(952)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (954)..(955)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (957)..(958)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (966)..(966)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (969)..(969)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (971)..(971)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (973)..(973)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (977)..(980)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (983)..(983)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (985)..(988)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (990)..(992)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (994)..(994)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (996)..(996)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (998)..(999)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1001)..(1011)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1013)..(1013)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1015)..(1017)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1020)..(1020)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1022)..(1027)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1029)..(1034)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1036)..(1036)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1040)..(1040)
<223> a, c, t, g, unknown or other

<400> 16
anttctattt nnngagacag tcataatgaa atacctattg cctacggcag ccgctggatt       60

gttattactc gcggcccagc cggccatggc ccaggtacag ctgcaggagt ctgggggagg      120

cttggtccag cctgggaggt ccctgagact ctcctgtgca gcctctggat tcaccttcag      180

taactttggc atgcactggg tctgccaggc tccaggcaag gggctggagt gggtggcaat      240

tatttcatat gatgcaagta gtgaatacta tgcagactcc gtgaagggcc gattcaccat      300

ctccagagac aattccagga acactcttta tctgcaaatg aacagcctga gacctgagga      360

cacggctgta tattactgtg cgaagaagga cggtcggagt gggagctact actactttga      420

ctactggggc cagggaaccc tggtcaccgt ctcctcaggt ggaggcggtt caggcggagg      480

tggctctggc ggtggcggat cggatgttgt gatgactcag tctccatcct ccctgtctgc      540

atctgtagga gacagagtca ccatcacttg ccgggcgagt caagatttta ggaattggtt      600

agcctggtat caggtgaaac caggaaaagc ccccaagccc ctgatctatg gtgcatccac      660

tttgcaaaat ggggtcccat ccaggttcag cggcagtggg tctganacag atttctctct      720

cactatcagc agcctgcagc ctgagnantt tgcaacttac ttttgtcaac nnntcacagt      780

ttccctccca ctttcncgga ggnacacgac tgganatcaa acgtgcggcc gcncatcatc      840

atcaccatca ngggncncnn anaaaactca tctcnaanag ganctgaatg ggccgcatan      900

actgtgaagt tgnttancaa actcntannn nantnnttta ctangncngn nnannannaa      960

cttaantcnt ncnctannnn gangnnnncn nngnangnna nnnnnnnnnn ngntnnnacn     1020

gnnnnnnann nnnngntacn g                                               1041


<210> 17
<211> 301
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (284)..(287)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (292)..(294)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Any amino acid

<400> 17
Xaa Leu Phe Xaa Glu Thr Val Ile Met Lys Tyr Leu Leu Pro Thr Ala 
1               5                   10                  15      


Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Gln Val 
            20                  25                  30          


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu 
        35                  40                  45              


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe Gly Met 
    50                  55                  60                  


His Trp Val Cys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ile 
65                  70                  75                  80  


Ile Ser Tyr Asp Ala Ser Ser Glu Tyr Tyr Ala Asp Ser Val Lys Gly 
                85                  90                  95      


Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr Leu Gln 
            100                 105                 110         


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
        115                 120                 125             


Lys Asp Gly Arg Ser Gly Ser Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser 
                165                 170                 175     


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
            180                 185                 190         


Ser Gln Asp Phe Arg Asn Trp Leu Ala Trp Tyr Gln Val Lys Pro Gly 
        195                 200                 205             


Lys Ala Pro Lys Pro Leu Ile Tyr Gly Ala Ser Thr Leu Gln Asn Gly 
    210                 215                 220                 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Xaa Thr Asp Phe Ser Leu 
225                 230                 235                 240 


Thr Ile Ser Ser Leu Gln Pro Glu Xaa Phe Ala Thr Tyr Phe Cys Gln 
                245                 250                 255     


Xaa Xaa Thr Val Ser Leu Pro Leu Xaa Arg Arg Xaa Thr Thr Gly Xaa 
            260                 265                 270         


Gln Thr Cys Gly Arg Xaa Ser Ser Ser Pro Ser Xaa Xaa Xaa Xaa Lys 
        275                 280                 285             


Thr His Leu Xaa Xaa Xaa Leu Asn Gly Pro His Xaa Leu 
    290                 295                 300     


<210> 18
<211> 989
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (2)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (691)..(691)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (727)..(727)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (877)..(877)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (896)..(896)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (898)..(898)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (910)..(911)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (935)..(935)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (938)..(938)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (941)..(941)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (952)..(952)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (980)..(980)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (982)..(982)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (984)..(984)
<223> a, c, t, g, unknown or other

<400> 18
gnnnntcnat ttnnngagac agtcataatg aaatacctat tgcctacggc agccgctgga       60

ttgttattac tcgcggccca gccggccatg gcccaggtgc agctgcagga gtctggggga      120

gacgtggtcc agcctgggag gtccctgaga ctctcctgtg cagcctctgg attcaccttc      180

agtagctatg gcatgcactg ggtccgccag gctccaggca aggggctgga gtgggtggca      240

gttatatcat atgatgaaag taataaatac tatgcagact ccgtgaaggg ccgattcacc      300

atctccagag acaattccaa gaacacactg tttctgcaaa tgaacagcct gagagctgag      360

gacacggctg tgtattactg tgcgaaagga cctgtcctaa ctggggagtt tgactattgg      420

ggccgtagaa ccctggtcac cgtctcctca ggtggaggcg gttcaggcgg aggtggctct      480

ggcggtggcg gatcgtctga gctgactcag gaccctgctg tgtctgtggc cttgggacag      540

acagtcagga tcacatgcca aggagacagc ctcaaaagct actatgcaag ttggtaccag      600

cagaagccag gacaggcccc tgtacttgtc atctatggtg aaaacagccg gccctccggg      660

atcccagacc gattctctgg ttccagctca ngaaacacag cttccttgac catcactggg      720

ggctcangcg gaagatgaag ctgactatta ttgtaactcc cgggacaaca gtggtaccca      780

tcttgaggta ttcggcggag ggaccaagct gaccgtccta ggtgcggccg cagaacaaaa      840

actcatctca gaagaggatc tgaatggggc cgcatanact gttgaaagtt gtttancnaa      900

acctcatacn naaaattcat ttactaacgt ctggnaanac nacaaacttt anatcgttac      960

gctaactatg agggctgtcn gngnaatgc                                        989


<210> 19
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Any amino acid

<400> 19
Xaa Xaa Xaa Phe Xaa Glu Thr Val Ile Met Lys Tyr Leu Leu Pro Thr 
1               5                   10                  15      


Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Gln 
            20                  25                  30          


Val Gln Leu Gln Glu Ser Gly Gly Asp Val Val Gln Pro Gly Arg Ser 
        35                  40                  45              


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
    50                  55                  60                  


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
65                  70                  75                  80  


Val Ile Ser Tyr Asp Glu Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Lys Gly Pro Val Leu Thr Gly Glu Phe Asp Tyr Trp Gly Arg Arg Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
                165                 170                 175     


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Lys 
            180                 185                 190         


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
        195                 200                 205             


Leu Val Ile Tyr Gly Glu Asn Ser Arg Pro Ser Gly Ile Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Ser Ser Xaa Asn Thr Ala Ser Leu Thr Ile Thr Gly 
225                 230                 235                 240 


Gly Ser Xaa Gly Arg 
                245 


<210> 20
<211> 892
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
gagacagtca taatgaaata cctattgcct acggcagccg ctggattgtt attactcgcg       60

gcccagccgg ccatggccca ggtacagctg caggagtctg ggggaggctt ggtacagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagcag ctatgccatg      180

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtggtagt      240

ggtggtagca catactacgc agactccgtg aagggccgat tcaccatctc cagagacaat      300

tccaagaaca cgctgtatct gcaaatgaac agcctgagag ctgaggacac ggctgtgtat      360

tactgtgcga agagctatgg ttcagttaaa ataagctgct ttgactactg gggccagagc      420

accctggtca ccgtctcctc aggtggaggc ggttcaggcg gaggtggctc tggcggtggc      480

ggatcggaaa ttgtgctgac gcagtctcca gactccctgg ctgtgtctct gggcgagagg      540

gccaccatca actgcaagtc cagccagagt gttctttaca actccaacaa taagaactac      600

ttagcttggt accagcagaa accaggacag tctcctgagt tgctcattta ctgggcatca      660

acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agaattcact      720

cttaccatca gcagcctgca ggctgaggat gtggcagttt attactgtca gcaattttat      780

agtactcctc cgacttttgg ccaggggacc aagctggaga tcaaacgtgc ggccgcacat      840

catcatcacc atcacggggc cgcagaacaa aaactcatct cagaagagga tc              892


<210> 21
<211> 977
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (3)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (707)..(707)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (747)..(747)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (749)..(749)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (772)..(772)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (775)..(775)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (799)..(800)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (808)..(808)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (830)..(830)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (836)..(837)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (852)..(853)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (855)..(858)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (872)..(872)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (877)..(877)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (882)..(882)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (890)..(891)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (895)..(895)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (901)..(902)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (904)..(904)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (908)..(909)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (920)..(920)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (928)..(928)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (933)..(933)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (935)..(936)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (938)..(939)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (942)..(942)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (947)..(947)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (950)..(950)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (953)..(953)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (955)..(955)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (957)..(957)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (959)..(959)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (964)..(965)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (967)..(968)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (970)..(970)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (972)..(976)
<223> a, c, t, g, unknown or other

<400> 21
gcnnntctat ttnnngagac agtcataatg aaatacctat tgcctacggc agccgctgga       60

ttgttattac tcgcggccca gccggccatg gcccaggtgc agctgtggag tctgggggag      120

gcgtggtcca gcctgggagg tccctgagac tctcctgtgc agcctctgga ttcaccttca      180

gtaactttgg catgcactgg gtctgccagg ctccaggcaa ggggctggag tgggtggcaa      240

ttatttcata tgatgcaagt agtgaatact atgcagactc cgtgaagggc cgattcacca      300

tctccagaga caattccagg aacactcttt atctgcaaat gaacagcctg agacctgagg      360

acacggctgt atattactgt gcgaagaagg acggtcggag tgggagctac tactactttg      420

actactgggg ccagggaacc ctggtcaccg tctcctcagg tggaggcggt tcaggcggag      480

gtggctctgg cggtggcgga tcggatgttg tgatgactca gtctccatcc tccctgtctg      540

catctgtagg agacagagtc accatcactt gccgggcgag tcaagatttt aggaattggt      600

tagcctggta tcaggtgaaa ccaggaaaag cccccaagcc cctgatctat ggtgcatcca      660

ctttgcaaaa tggggtccca tccaggttca gcggcagtgg gtctganaca gatttctctc      720

tcactatcag cagcctgcag cctgagnant ttgcaactta cttttgtcaa cnggntcaca      780

gtttccctcc cactttcgnn ggaggganac gactggagat taaacgtgcn gccgcnnaca      840

aaactcatct cnnannnntc tgaatggggc cncatanact gntgaaagtn nttancaaac      900

nncntacnna aaattcattn ctacgtcngg aanannanna antttanatn gtncncnant      960

atgnngnngn cnnnnna                                                     977


<210> 22
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
ggcccagccg gcc                                                          13


<210> 23
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
ggcccagccg gccatggccc aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc       60

tggggcctca gtgaaggtct cctgcaaggc ttctggttac acctttacc                  109


<210> 24
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
ggcccagccg gccatggccc aggtgcagct ggtgcagtct gggggaggcg tggtccagcc       60

tgggaggtcc ctgagactct cctgtgcagc ctctggattc accttcagt                  109


<210> 25
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
ggcccagccg gccatggccc aggtacagct gcagcagtca ggctcaggac tggtgaagcc       60

ttcacagacc ctgtccctca cctgctctgt ctctggtgac tccatctcc                  109


<210> 26
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
ggcccagccg gccatggccc aggtgcagct gcaggagtcg gggccaggac tggtgaagcc       60

ttcggagacc ctgtccctcg tctgcactgt ctctggtggc tccctcagt                  109


<210> 27
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
ggcccagccg gccatggccc aggtgcagct ggtgcagtct ggagcagagg tgaaaaagcc       60

cgggcagtct ctgatgatct cctgtcaggg ttctggatac agctttagc                  109


<210> 28
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
ggcccagccg gccatggccc aggtgcagct ggtgcagtct ggggcagagg tgaaaaagcc       60

cgggcagtct ctgaggatct cctgtaaggg tgctggatac agctttagc                  109


<210> 29
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
ggcccagccg gccatggccc aggtgcagct gcaggagtcg ggggaggcgt ggtccagcct       60

gggaggtccc tgagactctc ctgtgcagcg tctggattca ccttcagt                   108


<210> 30
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
ggcccagccg gccatggcca ggtgcagctg gtggagtctg ggggaggctt ggtacagcct       60

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagc                   108


<210> 31
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
ggcccagccg gccatggccc aggtgcagct gtggagtctg ggggaggcgt ggtccagcct       60

gggaggtccc tgagactctc ctgtgcagcc tctggattca ccttcagt                   108


<210> 32
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
ggcccagccg gccatggccc aggtgcagct ggtgcgtctg gaggagactt gatccagcct       60

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttaat                   108


<210> 33
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
ggcccagccg gccatggccc aggtgcagct gcaggagtcg ggggagacgt ggtccagcct       60

gggaggtccc tgagactctc ctgtgcagcc tctggattca ccttcagt                   108


<210> 34
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
ggcccagccg gccatggccg agtgcagctg gtggagtctg gggctgaggt gacgaagcct       60

ggggcctcag taagggtctc ctgcaaggct tctggataca ccttcagc                   108


<210> 35
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
atatatccat ggcccaggtg cagctgcagg agtctggggg aggcgtggtc c                51


<210> 36
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
atatatccat ggcccaggtg cagctggtgg agtctggggg aggcttggta c                51


<210> 37
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
gccggccatg gcccaggtac agctgcagga gtctggggga ggcttggt                    48


<210> 38
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
cccgtgatgg tgatgatgat gtgcggccgc acgtttgatc tccag                       45


<210> 39
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Val Gln Ile Ile Asn Lys 
1               5       


<210> 40
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Val Gln Ile Val Tyr Lys 
1               5       


<210> 41
<211> 201
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> misc_feature
<222> (1)..(100)
<223> This region may encompass 3-100 "Gly" residues

<220>
<221> misc_feature
<222> (102)..(201)
<223> This region may encompass 3-100 "Gly" residues

<400> 41
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    130                 135                 140                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                165                 170                 175     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        195                 200     


<210> 42
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 42
His His His His His His 
1               5       


<210> 43
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(16)
<223> Any amino acid

<400> 43
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Lys Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210> 44
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(17)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(43)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Any amino acid

<400> 44
Ser Xaa Leu Xaa Asn Xaa Xaa Xaa Xaa Xaa Leu Leu Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Asn Leu Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa 
        35                  40                  45  


<210> 45
<211> 1
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Ser 
1   


<210> 46
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Leu Leu Leu 
1           


<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Leu Pro Gly Gln Gln Trp Tyr Pro Ser 
1               5                   


<210> 48
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Any amino acid

<400> 48
Gly Ile Arg Arg Arg Asp Gln Ala Asp Arg Pro Arg Cys Gly Arg Arg 
1               5                   10                  15      


Thr Lys Thr His Leu Arg Arg Gly Ser Glu Trp Gly Arg Ile Xaa Cys 
            20                  25                  30          


<210> 49
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<400> 49
Lys Leu Phe Xaa Xaa Thr Ser Tyr Xaa Lys Phe Ile Tyr 
1               5                   10              


<210> 50
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Any amino acid

<400> 50
Arg Leu Xaa Xaa Xaa Gln Thr Leu Xaa Arg Tyr Ala Asn Tyr Glu Gly 
1               5                   10                  15      


Cys Xaa Xaa Asn 
            20  


