                         SEQUENCE LISTING

<110>  Rhode Island Hospital
 
<120>  DIFFERENTIAL EXPRESSION OF NOVEL PROTEIN MARKERS FOR THE 
       DIAGNOSIS AND TREATMENT OF EOSINOPHILIC ESOPHAGITIS

<130>  21486-616001WO

<140>  PCT/US2013/064392
<141>  2013-10-10

<150>  US 61/712,082
<151>  2012-10-10

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide primer

<400>  1
tggaaggacg ggttaattct ga                                                22


<210>  2
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide primer

<400>  2
gcgaaacctc aaagtcaact ct                                                22


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide primer

<400>  3
attgctacaa cccacacgca aagg                                              24


<210>  4
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide primer

<400>  4
tcgtactcat ttgggaagcc tgga                                              24


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide primer

<400>  5
tgggtctgct tccagaaacc atct                                              24


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide primer

<400>  6
tgtgtgacga gtgcctgatt gtct                                              24


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide primer

<400>  7
tcatcacttc tgagcacgga gcaa                                              24


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide primer

<400>  8
tgtgtgacga gtgcctgatt gtct                                              24


<210>  9
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide primer

<400>  9
taccctccac tcaaggaggt agaact                                            26


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide primer

<400>  10
ccctttccat actccactct ttgg                                              24


<210>  11
<211>  2707
<212>  DNA
<213>  Homo sapiens

<400>  11
catctttgag caagatgggt ctctaccgca tccgcgtgtc cactggggcc tcgctctatg       60

ccggttccaa caaccaggtg cagctgtggc tggtcggcca gcacggggag gcggcgctcg      120

ggaagcgact gtggcccgca cggggcaagg agacagaact caaggtggaa gtaccggagt      180

atctggggcc gctgctgttt gtgaaactgc gcaaacggca cctccttaag gacgacgcct      240

ggttctgcaa ctggatctct gtgcagggcc ccggagccgg ggacgaggtc aggttccctt      300

gttaccgctg ggtggagggc aacggcgtcc tgagcctgcc tgaaggcacc ggccgcactg      360

tgggcgagga ccctcagggc ctgttccaga aacaccggga agaagagctg gaagagagaa      420

ggaagttgta ccggtgggga aactggaagg acgggttaat tctgaatatg gctggggcca      480

aactatatga cctccctgtg gatgagcgat ttctggaaga caagagagtt gactttgagg      540

tttcgctggc caaggggctg gccgacctcg ctatcaaaga ctctctaaat gttctgactt      600

gctggaagga tctagatgac ttcaaccgga ttttctggtg tggtcagagc aagctggctg      660

agcgcgtgcg ggactcctgg aaggaagatg ccttatttgg gtaccagttt cttaatggcg      720

ccaaccccgt ggtgctgagg cgctctgctc accttcctgc tcgcctagtg ttccctccag      780

gcatggagga actgcaggcc cagctggaga aggagctgga gggaggcaca ctgttcgaag      840

ctgacttctc cctgctggat gggatcaagg ccaacgtcat tctctgtagc cagcagcacc      900

tggctgcccc tctagtcatg ctgaaattgc agcctgatgg gaaactcttg cccatggtca      960

tccagctcca gctgccccgc acaggatccc caccacctcc ccttttcttg cctacggatc     1020

ccccaatggc ctggcttctg gccaaatgct gggtgcgcag ctctgacttc cagctccatg     1080

agctgcagtc tcatcttctg aggggacact tgatggctga ggtcattgtt gtggccacca     1140

tgaggtgcct gccgtcgata catcctatct tcaagcttat aattccccac ctgcgataca     1200

ccctggaaat taacgtccgg gccaggactg ggctggtctc tgacatggga attttcgacc     1260

agataatgag cactggtggg ggaggccacg tgcagctgct caagcaagct ggagccttcc     1320

taacctacag ctccttctgt ccccctgatg acttggccga ccgggggctc ctgggagtga     1380

agtcttcctt ctatgcccaa gatgcgctgc ggctctggga aatcatctat cggtatgtgg     1440

aaggaatcgt gagtctccac tataagacag acgtggctgt gaaagacgac ccagagctgc     1500

agacctggtg tcgagagatc actgaaatcg ggctgcaagg ggcccaggac cgagggtttc     1560

ctgtctcttt acaggctcgg gaccaggttt gccactttgt caccatgtgt atcttcacct     1620

gcaccggcca acacgcctct gtgcacctgg gccagctgga ctggtactct tgggtgccta     1680

atgcaccctg cacgatgcgg ctgcccccgc caaccaccaa ggatgcaacg ctggagacag     1740

tgatggcgac actgcccaac ttccaccagg cttctctcca gatgtccatc acttggcagc     1800

tgggcagacg ccagcccgtt atggtggctg tgggccagca tgaggaggag tatttttcgg     1860

gccctgagcc taaggctgtg ctgaagaagt tcagggagga gctggctgcc ctggataagg     1920

aaattgagat ccggaatgca aagctggaca tgccctacga gtacctgcgg cccagcgtgg     1980

tggaaaacag tgtggccatc taagcgtcgc caccctttgg ttatttcagc ccccatcacc     2040

caagccacaa gctgacccct tcgtggttat agccctgccc tcccaagtcc caccctcttc     2100

ccatgtccca ccctccctag aggggcacct tttcatggtc tctgcaccca gtgaacacat     2160

tttactctag aggcatcacc tgggacctta ctcctctttc cttccttcct cctttcctat     2220

cttccttcct ctctctcttc ctctttcttc attcagatct atatggcaaa tagccacaat     2280

tatataaatc atttcaagac tagaataggg ggatataata catattactc cacacctttt     2340

atgaatcaaa tatgattttt ttgttgttgt taagacagag tctcactttg acacccaggc     2400

tggagtgcag tggtgccatc accacggctc actgcagcct cagcgtcctg ggctcaaatg     2460

atcctcccac ctcagcctcc tgagtagctg ggactacagg ctcatgccat catgcccagc     2520

taatattttt ttattttcgt ggagacgggg cctcactatg ttgcctaggc tggaaatagg     2580

attttgaacc caaattgagt ttaacaataa taaaaagttg ttttacgcta aagatggaaa     2640

agaactagga ctgaactatt ttaaataaaa tattggcaaa agaaaaaaaa aaaaaaaaaa     2700

aaaaaaa                                                               2707


<210>  12
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Leu Tyr Arg Ile Arg Val Ser Thr Gly Ala Ser Leu Tyr Ala 
1               5                   10                  15      


Gly Ser Asn Asn Gln Val Gln Leu Trp Leu Val Gly Gln His Gly Glu 
            20                  25                  30          


Ala Ala Leu Gly Lys Arg Leu Trp Pro Ala Arg Gly Lys Glu Thr Glu 
        35                  40                  45              


Leu Lys Val Glu Val Pro Glu Tyr Leu Gly Pro Leu Leu Phe Val Lys 
    50                  55                  60                  


Leu Arg Lys Arg His Leu Leu Lys Asp Asp Ala Trp Phe Cys Asn Trp 
65                  70                  75                  80  


Ile Ser Val Gln Gly Pro Gly Ala Gly Asp Glu Val Arg Phe Pro Cys 
                85                  90                  95      


Tyr Arg Trp Val Glu Gly Asn Gly Val Leu Ser Leu Pro Glu Gly Thr 
            100                 105                 110         


Gly Arg Thr Val Gly Glu Asp Pro Gln Gly Leu Phe Gln Lys His Arg 
        115                 120                 125             


Glu Glu Glu Leu Glu Glu Arg Arg Lys Leu Tyr Arg Trp Gly Asn Trp 
    130                 135                 140                 


Lys Asp Gly Leu Ile Leu Asn Met Ala Gly Ala Lys Leu Tyr Asp Leu 
145                 150                 155                 160 


Pro Val Asp Glu Arg Phe Leu Glu Asp Lys Arg Val Asp Phe Glu Val 
                165                 170                 175     


Ser Leu Ala Lys Gly Leu Ala Asp Leu Ala Ile Lys Asp Ser Leu Asn 
            180                 185                 190         


Val Leu Thr Cys Trp Lys Asp Leu Asp Asp Phe Asn Arg Ile Phe Trp 
        195                 200                 205             


Cys Gly Gln Ser Lys Leu Ala Glu Arg Val Arg Asp Ser Trp Lys Glu 
    210                 215                 220                 


Asp Ala Leu Phe Gly Tyr Gln Phe Leu Asn Gly Ala Asn Pro Val Val 
225                 230                 235                 240 


Leu Arg Arg Ser Ala His Leu Pro Ala Arg Leu Val Phe Pro Pro Gly 
                245                 250                 255     


Met Glu Glu Leu Gln Ala Gln Leu Glu Lys Glu Leu Glu Gly Gly Thr 
            260                 265                 270         


Leu Phe Glu Ala Asp Phe Ser Leu Leu Asp Gly Ile Lys Ala Asn Val 
        275                 280                 285             


Ile Leu Cys Ser Gln Gln His Leu Ala Ala Pro Leu Val Met Leu Lys 
    290                 295                 300                 


Leu Gln Pro Asp Gly Lys Leu Leu Pro Met Val Ile Gln Leu Gln Leu 
305                 310                 315                 320 


Pro Arg Thr Gly Ser Pro Pro Pro Pro Leu Phe Leu Pro Thr Asp Pro 
                325                 330                 335     


Pro Met Ala Trp Leu Leu Ala Lys Cys Trp Val Arg Ser Ser Asp Phe 
            340                 345                 350         


Gln Leu His Glu Leu Gln Ser His Leu Leu Arg Gly His Leu Met Ala 
        355                 360                 365             


Glu Val Ile Val Val Ala Thr Met Arg Cys Leu Pro Ser Ile His Pro 
    370                 375                 380                 


Ile Phe Lys Leu Ile Ile Pro His Leu Arg Tyr Thr Leu Glu Ile Asn 
385                 390                 395                 400 


Val Arg Ala Arg Thr Gly Leu Val Ser Asp Met Gly Ile Phe Asp Gln 
                405                 410                 415     


Ile Met Ser Thr Gly Gly Gly Gly His Val Gln Leu Leu Lys Gln Ala 
            420                 425                 430         


Gly Ala Phe Leu Thr Tyr Ser Ser Phe Cys Pro Pro Asp Asp Leu Ala 
        435                 440                 445             


Asp Arg Gly Leu Leu Gly Val Lys Ser Ser Phe Tyr Ala Gln Asp Ala 
    450                 455                 460                 


Leu Arg Leu Trp Glu Ile Ile Tyr Arg Tyr Val Glu Gly Ile Val Ser 
465                 470                 475                 480 


Leu His Tyr Lys Thr Asp Val Ala Val Lys Asp Asp Pro Glu Leu Gln 
                485                 490                 495     


Thr Trp Cys Arg Glu Ile Thr Glu Ile Gly Leu Gln Gly Ala Gln Asp 
            500                 505                 510         


Arg Gly Phe Pro Val Ser Leu Gln Ala Arg Asp Gln Val Cys His Phe 
        515                 520                 525             


Val Thr Met Cys Ile Phe Thr Cys Thr Gly Gln His Ala Ser Val His 
    530                 535                 540                 


Leu Gly Gln Leu Asp Trp Tyr Ser Trp Val Pro Asn Ala Pro Cys Thr 
545                 550                 555                 560 


Met Arg Leu Pro Pro Pro Thr Thr Lys Asp Ala Thr Leu Glu Thr Val 
                565                 570                 575     


Met Ala Thr Leu Pro Asn Phe His Gln Ala Ser Leu Gln Met Ser Ile 
            580                 585                 590         


Thr Trp Gln Leu Gly Arg Arg Gln Pro Val Met Val Ala Val Gly Gln 
        595                 600                 605             


His Glu Glu Glu Tyr Phe Ser Gly Pro Glu Pro Lys Ala Val Leu Lys 
    610                 615                 620                 


Lys Phe Arg Glu Glu Leu Ala Ala Leu Asp Lys Glu Ile Glu Ile Arg 
625                 630                 635                 640 


Asn Ala Lys Leu Asp Met Pro Tyr Glu Tyr Leu Arg Pro Ser Val Val 
                645                 650                 655     


Glu Asn Ser Val Ala Ile 
            660         


<210>  13
<211>  1439
<212>  DNA
<213>  Homo sapiens

<400>  13
agtcacattt cagccactgc tctgagaatt tgtgagcagc ccctaacagg ctgttacttc       60

actacaactg acgatatgat catcttaatt tacttatttc tcttgctatg ggaagacact      120

caaggatggg gattcaagga tggaattttt cataactcca tatggcttga acgagcagcc      180

ggtgtgtacc acagagaagc acggtctggc aaatacaagc tcacctacgc agaagctaag      240

gcggtgtgtg aatttgaagg cggccatctc gcaacttaca agcagctaga ggcagccaga      300

aaaattggat ttcatgtctg tgctgctgga tggatggcta agggcagagt tggatacccc      360

attgtgaagc cagggcccaa ctgtggattt ggaaaaactg gcattattga ttatggaatc      420

cgtctcaata ggagtgaaag atgggatgcc tattgctaca acccacacgc aaaggagtgt      480

ggtggcgtct ttacagatcc aaagcaaatt tttaaatctc caggcttccc aaatgagtac      540

gaagataacc aaatctgcta ctggcacatt agactcaagt atggtcagcg tattcacctg      600

agttttttag attttgacct tgaagatgac ccaggttgct tggctgatta tgttgaaata      660

tatgacagtt acgatgatgt ccatggcttt gtgggaagat actgtggaga tgagcttcca      720

gatgacatca tcagtacagg aaatgtcatg accttgaagt ttctaagtga tgcttcagtg      780

acagctggag gtttccaaat caaatatgtt gcaatggatc ctgtatccaa atccagtcaa      840

ggaaaaaata caagtactac ttctactgga aataaaaact ttttagctgg aagatttagc      900

cacttataaa aaaaaaaaaa aggatgatca aaacacacag tgtttatgtt ggaatctttt      960

ggaactcctt tgatctcact gttattatta acatttattt attatttttc taaatgtgaa     1020

agcaatacat aatttaggga aaattggaaa atataggaaa ctttaaacga gaaaatgaaa     1080

cctctcataa tcccactgca tagaaataac aagcgttaac attttcatat ttttttcttt     1140

cagtcatttt tctatttgtg gtatatgtat atatgtacct atatgtattt gcatttgaaa     1200

ttttggaatc ctgctctatg tacagttttg tattatactt tttaaatctt gaactttata     1260

aacattttct gaaatcattg attattctac aaaaacatga ttttaaacag ctgtaaaata     1320

ttctatgata tgaatgtttt atgcattatt taagcctgtc tctattgttg gaatttcagg     1380

tcattttcat aaatattgtt gcaataaata tccttgaaca cacaaaaaaa aaaaaaaaa      1439


<210>  14
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ile Ile Leu Ile Tyr Leu Phe Leu Leu Leu Trp Glu Asp Thr Gln 
1               5                   10                  15      


Gly Trp Gly Phe Lys Asp Gly Ile Phe His Asn Ser Ile Trp Leu Glu 
            20                  25                  30          


Arg Ala Ala Gly Val Tyr His Arg Glu Ala Arg Ser Gly Lys Tyr Lys 
        35                  40                  45              


Leu Thr Tyr Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly His 
    50                  55                  60                  


Leu Ala Thr Tyr Lys Gln Leu Glu Ala Ala Arg Lys Ile Gly Phe His 
65                  70                  75                  80  


Val Cys Ala Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro Ile 
                85                  90                  95      


Val Lys Pro Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile Asp 
            100                 105                 110         


Tyr Gly Ile Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys Tyr 
        115                 120                 125             


Asn Pro His Ala Lys Glu Cys Gly Gly Val Phe Thr Asp Pro Lys Gln 
    130                 135                 140                 


Ile Phe Lys Ser Pro Gly Phe Pro Asn Glu Tyr Glu Asp Asn Gln Ile 
145                 150                 155                 160 


Cys Tyr Trp His Ile Arg Leu Lys Tyr Gly Gln Arg Ile His Leu Ser 
                165                 170                 175     


Phe Leu Asp Phe Asp Leu Glu Asp Asp Pro Gly Cys Leu Ala Asp Tyr 
            180                 185                 190         


Val Glu Ile Tyr Asp Ser Tyr Asp Asp Val His Gly Phe Val Gly Arg 
        195                 200                 205             


Tyr Cys Gly Asp Glu Leu Pro Asp Asp Ile Ile Ser Thr Gly Asn Val 
    210                 215                 220                 


Met Thr Leu Lys Phe Leu Ser Asp Ala Ser Val Thr Ala Gly Gly Phe 
225                 230                 235                 240 


Gln Ile Lys Tyr Val Ala Met Asp Pro Val Ser Lys Ser Ser Gln Gly 
                245                 250                 255     


Lys Asn Thr Ser Thr Thr Ser Thr Gly Asn Lys Asn Phe Leu Ala Gly 
            260                 265                 270         


Arg Phe Ser His Leu 
        275         


<210>  15
<211>  12747
<212>  DNA
<213>  Homo sapiens

<400>  15
cttttggtga acaaggttca catttattgc caaaagatgt ctactctcct ggaaaacatc       60

tttgccataa ttaatctttt caagcaatat tcaaaaaaag ataaaaacac tgacacattg      120

agtaaaaaag agctgaagga acttctggaa aaggaatttc ggcaaatcct gaagaatcca      180

gatgacccag atatggttga tgtcttcatg gatcacttgg atatagacca caacaagaaa      240

attgacttca ctgagtttct tctgatggta ttcaagttgg ctcaagcata ttatgagtct      300

accagaaaag agaatttacc gatatcagga cacaagcaca gaaagcacag tcatcatgat      360

aaacatgaag ataataaaca ggaagaaaac aaagaaaaca gaaaaagacc ctcaagtctg      420

gaaagaagaa acaatagaaa agggaataag ggaagatcca agagcccaag agaaacaggg      480

gggaaaaggc atgaatctag ttctgaaaaa aaagaaagaa aaggatattc acctactcat      540

agagaagaag aatatggaaa aaaccatcat aactcaagta aaaaagagaa aaacaagact      600

gaaaatacta gattaggaga caataggaag aggctaagtg aaagacttga agagaaagaa      660

gacaatgaag aaggagtata tgattatgaa aatacaggaa gaatgactca aaaatggata      720

caatcaggcc atattgccac atattacaca atccaggatg aagcctatga caccactgat      780

agtctattag aagaaaacaa aatatatgaa agatcaaggt catctgatgg caaatcatca      840

tctcaagtga acaggtcaag acatgaaaat acaagccagg taccattgca ggagtccagg      900

acaagaaagc gtaggggatc cagagttagc caggacaggg acagtgaggg acactcagaa      960

gactctgaga ggcactctgg gtcggcttcc agaaaccatc atggatctgc gtgggagcag     1020

tcaagagatg gctccagaca ccccaggtcc catgatgaag acagagccag tcatgggcac     1080

tctgcagaca gctccagaca atcaggcact cgtcacgcag agacttcctc tcgtggacag     1140

actgcatcat cccatgaaca ggcaagatca agtccaggag aaagacatgg atccggccac     1200

cagcagtcag cagacagctc cagacactca gccactgggc gcgggcaagc ttcatctgca     1260

gtcagcgatc gtggacaccg ggggtctagc ggtagtcagg ccagtgacag tgagggacat     1320

tcagaaaact cagacacaca atcagtgtca ggccacggaa aggctgggct gagacagcag     1380

agccaccaag agtccacacg tggccggtca ggggaacggt ctggacgttc agggtcttcc     1440

ctctaccagg tgagcactca tgaacagcct gactctgccc atggacggac cgggaccagc     1500

actggaggaa gacaaggatc gcaccacgag caggcacgag acagctccag gcattcagcg     1560

tcccaagagg gtcaggacac cattcgtgga cacccggggt caagcagagg aggaaggcag     1620

ggatcccacc acgagcaatc ggtaaatagg tctggacact caggttccca tcacagccac     1680

accacatccc agggaaggtc tgatgcctcc catgggcagt caggatccag aagtgcaagc     1740

agacaaacac gaaatgagga acaatcagga gacggcacca ggcactcagg gtcacgtcat     1800

catgaagctt cctctcaggc tgacagctct agacactcac aggtgggcca gggacaatca     1860

tcggggccca ggacaagtag gaaccaggga tccagtgtta gccaggacag tgacagtcag     1920

ggacactcag aagactctga gaggtggtct gggtctgctt ccagaaacca tcatggatct     1980

gctcaggagc agtcaagaga tggctccaga caccccaggt cccatcacga agacagagct     2040

ggtcatgggc actctgcaga cagctccaga aaatcaggca ctcgtcacac acagaattcc     2100

tctagtggac aggctgcgtc atcccatgaa caggcaagat caagtgcagg agaaagacat     2160

ggatcccgcc accagctcca gtcagcagac agctccagac actcaggcac tgggcacgga     2220

caagcttcat ctgcagtcag agacagtgga caccgagggt ccagtggtag tcaggccact     2280

gacagtgagg gacattcaga agactcagac acacagtcag tgtcaggcca tggacaggct     2340

ggtcaccatc agcagagcca ccaagagtcc gcacgtgacc ggtcagggga aaggtctcga     2400

cgttcagggt ctttcctcta ccaggtgagc actcataaac agtctgagtc ctcccatgga     2460

tggacagggc ccagcactgg agtaagacaa ggatcccacc atgagcaggc acgagacaac     2520

tccaggcact cagcatccca agatggtcag gacaccattc gtggacaccc ggggtcaagc     2580

agaagaggaa ggcaggggtc ccaccacgag caatcggtag ataggtctgg acactcaggg     2640

tcccatcaca gccacaccac atcccaggga aggtctgatg cctcccgtgg gcagtcagga     2700

tccagaagtg caagcagaac aacacgtaat gaggaacaat caagagacgg ctccaggcac     2760

tcagggtcac gtcaccatga agcttcctct catgccgaca tctctagaca ctcacaggca     2820

ggccagggac aatcagaggg gtccaggaca agcaggcgcc agggatccag tgttagccag     2880

gacagtgaca gtgagggaca ttcagaagac tctgagaggt ggtctgggtc tgcttccaga     2940

aaccatcgtg gatctgctca ggagcagtca agacatggct ccagacaccc caggtcccat     3000

cacgaagaca gagccggtca cgggcactct gcagacagct ccagacaatc aggaactcct     3060

cacgcagaga cttcctctgg tggacaggct gcgtcatccc atgaacaggc aagatcaagt     3120

ccaggagaaa gacacggatc ccgccaccag cagtcagcag acagctccag acactcaggc     3180

attccgcgca gacaagcttc atctgcagtc agagacagtg gacactgggg gtccagtggt     3240

agtcaggcca gtgatagtga gggacattca gaggagtcag acacacagtc agtgtcaggc     3300

catggacagg atgggcccca tcagcagagc caccaagagt ccgcacgtga ctggtcaggg     3360

ggaaggtctg gacgttcagg gtctttcatc taccaggtga gcactcatga acagtctgag     3420

tctgcccatg ggcggaccag gaccagcact ggacgaagac aaggatccca ccacgagcag     3480

gcacgagaca gctccaggca ctcagcgtcc caagagggtc aggacaccat tcgtgcacac     3540

ccggggtcaa ggagaggagg aaggcaggga tcccaccatg agcaatcggt agatagatct     3600

ggacactcag ggtcccatca cagccacacc acatcccagg gaaggtctga tgcctcccat     3660

gggcagtcag gatccagaag tgcaagcaga caaactcgta aggacaaaca atcaggagac     3720

ggctccaggc actcagggtc acgtcaccat gaagctgcct cttgggctga cagctctaga     3780

cactcacagg tgggacagga acaatcatcg gggtccagga caagcaggca ccagggatcc     3840

agtgttagcc aggacagtga cagtgagaga cactcagacg actccgagag gttgtctggg     3900

tctgcttcca gaaaccatca tggatcttct cgggagcagt caagagatgg ctccagacac     3960

cctgggttcc atcaagaaga cagagccagt cacgggcact ctgcagacag ctccagacaa     4020

tcaggcactc atcacacaga gtcttcctct catggacagg ctgtgtcatc ccatgaacag     4080

gcaagatcaa gtccaggaga aagacatgga tcccgccacc agcagtcagc agacagctcc     4140

agacactcag gcattgggca cagacaagct tcatctgcag tcagagacag tggacaccga     4200

gggtccagtg gtagtcaggt cactaacagt gagggacatt cagaagactc agacacacag     4260

tcagtgtcag cccacggaca agctgggccc catcagcaga gccacaaaga gtccgcacgt     4320

ggccagtcag gggaaagctc tggacgttca aggtctttcc tctaccaggt gagctctcat     4380

gaacagtctg agtccacaca cggacagact gcacccagca ctggaggaag acaaggatcc     4440

cgccatgagc aggcacgaaa cagctctagg cactcagcat cccaagacgg tcaggacacc     4500

attcgtggac acccggggtc aagcagagga ggaaggcagg gatcctacca cgagcaatca     4560

gtagataggt ctggacactc agggtaccat cacagccaca ccacacccca gggaaggtct     4620

gatgcctccc atgggcagtc aggacccaga agtgcaagca ggcaaacaag aaatgaggaa     4680

caatcaggag acggctccag gcactcaggg tcacgtcacc atgaaccttc cactcgggcc     4740

ggcagctcta gacactcaca ggtgggccag ggagaatcag cggggtccaa gacaagcagg     4800

cgccagggat ccagtgttag tcaggacagg gacagtgagg gacactcaga agactctgag     4860

aggcggtctg agtcggcttc cagaaaccat tatggatctg ctcgggagca gtcaagacat     4920

ggctccagga accccaggtc ccatcaagaa gatagagcca gtcatgggca ctctgcagag     4980

agctccagac aatcaggcac tcgtcatgca gagacttcct ctggtggaca ggctgcatca     5040

tcccaggaac aggcaaggtc aagtccagga gaaagacatg gatcccgcca ccagcagtca     5100

gcagacagct ccacagactc aggcactggg cgcagacaag attcatctgt agtcggagac     5160

agtggaaacc gagggtccag tggtagccag gccagtgaca gcgagggaca ctcagaagag     5220

tcagacacac agtcagtgtc agcccacgga caggctgggc cccatcagca gagccaccaa     5280

gagtccacac gtggccagtc aggggaaagg tctggacgtt cagggtcttt cctctaccag     5340

gtgagcactc atgaacagtc tgagtccgcc catggacgca cagggcccag cactggagga     5400

agacaaagat cccgccacga gcaggcacga gacagctcca ggcactcagc gtcccaagag     5460

ggtcaggaca ccattcgtgg acacccaggg tcaagcagag gaggaaggca gggatcccac     5520

tatgagcaat cggtagatag ttctggacac tcagggtctc atcacagcca caccacgtcc     5580

caggaaaggt ctgatgtctc ccgtgggcag tcaggatcca gaagtgtcag cagacaaaca     5640

cgtaatgaga aacaatcagg agacggctcc aggcactcag ggtcgcgtca ccatgaagct     5700

tcctctcggg ccgacagctc tagacactcg caggtgggcc agggacaatc atcagggccc     5760

aggacaagca ggaaccaggg atccagtgtt agccaggaca gtgacagtca gggacactca     5820

gaagactctg agaggtggtc tgggtctgct tccagaaacc atcttggatc tgcttgggag     5880

cagtcaagag atggctccag acaccctggg tcccatcacg aagacagagc cggtcacggg     5940

cactctgcag acagctccag acaatcaggc actcgtcaca cagagtcttc ctctcgtgga     6000

caggctgcgt catcccatga acaggcaaga tcaagtgcag gagaaagaca tggatcccac     6060

caccagctcc agtcagcaga cagctccaga cactcaggca ttgggcatgg acaagcttca     6120

tctgcagtca gagacagtgg acaccgaggg tacagtggta gtcaggccag tgacagtgag     6180

ggacattcag aagactcaga cacacagtca gtgtcagcac agggaaaagc tgggccccat     6240

cagcagagcc acaaagagtc cgcacgtggc cagtcagggg aaagctctgg acgttcaggg     6300

tctttcctct accaggtgag cactcatgaa cagtctgagt ccacccatgg acagtctgcg     6360

cccagcactg gaggaagaca aggatcccat tatgatcagg cacaagacag ctccaggcac     6420

tcagcatccc aagagggtca ggacaccatt cgtggacacc cggggccaag cagaggagga     6480

agacaggggt cccaccaaga gcaatcggta gataggtctg gacactcagg gtctcatcac     6540

agccacacca catcccaggg aaggtctgat gcctcccgtg ggcagtcagg atccagaagt     6600

gcaagcagaa aaacatatga caaggaacaa tcaggagatg gctctaggca ctcagggtcg     6660

catcatcatg aagcttcctc ttgggccgac agctctagac actcactggt gggccaggga     6720

caatcatcag ggcccaggac aagcaggccc cggggatcca gtgttagcca ggacagtgac     6780

agtgagggac actcagaaga ttctgagagg cggtctgggt ctgcgtccag aaaccatcat     6840

ggatctgctc aggagcagtc aagagatggc tccagacacc ccaggtccca tcacgaagac     6900

agagccggtc atgggcactc tgcagagagc tccagacaat caggcactca tcatgcagag     6960

aattcctctg gtggacaggc tgcatcatcc catgaacagg caagatcaag tgcaggagag     7020

agacacggat cccaccacca gcagtcagca gacagctcca gacactcagg cattgggcac     7080

ggacaagctt catctgcagt cagagacagt ggacaccgag ggtccagtgg tagtcaggcc     7140

agtgacagtg agggacattc agaagactca gacacacagt cagtgtcagc ccacggacag     7200

gctgggcccc atcagcagag ccaccaagag tccacacgtg gccggtcagc aggaaggtct     7260

ggacgttcag ggtctttcct ctaccaggtg agcactcatg aacagtctga gtccgcccat     7320

ggacggaccg ggaccagcac tggaggaaga caaggatccc accacaagca ggcacgagac     7380

agctccaggc actcaacgtc ccaagagggt caggacacca ttcatggaca cccggggtca     7440

agcagtggag gaaggcaggg atcccactac gagcaattgg tagatagatc tggacactca     7500

gggtctcatc acagccacac cacatcccag ggaaggtctg atgcctccca tgggcactca     7560

ggatccagaa gtgcaagcag acaaactcgt aacgatgaac aatcaggaga cggctccagg     7620

cactcagggt cgcgtcacca tgaagcttcc tctcgggccg acagctctgg acactcgcag     7680

gtgggccagg gacaatcaga ggggcccagg acaagcagga actggggatc cagttttagc     7740

caggacagtg acagtcaggg acactcagaa gactctgaga ggtggtctgg gtctgcttcc     7800

agaaaccatc atggatctgc tcaggagcag ctaagagatg gctccagaca ccccaggtcc     7860

catcaagaag acagagctgg tcatgggcac tctgcagaca gctccagaca atcaggcact     7920

cgtcacacac agacttcctc tggtggacag gctgcatcat cccatgaaca ggcaagatca     7980

agtgcaggag aaagacatgg atcccaccac cagcagtcag cagacagctc cagacactca     8040

ggcattgggc acggacaagc ttcatctgca gtcagagaca gtggacaccg agggtacagt     8100

ggtagtcagg ccagtgacaa tgagggacat tcagaagact cagacacaca gtcagtgtca     8160

gcccacggac aggctgggtc ccatcagcag agccaccaag agtccgcacg tggccggtca     8220

ggggaaacgt ctggacattc aggatctttc ctctaccagg tgagcactca tgaacagtct     8280

gagtcctccc atggatggac ggggcccagc actagaggaa gacaaggatc ccgccatgag     8340

caggcacaag acagctccag gcactcagca tcccaagacg gtcaggacac cattcgtgga     8400

cacccggggt caagcagagg aggaaggcag gggtaccacc acgagcattc ggtagatagc     8460

tctggacact cagggtccca tcacagccac accacatccc agggaaggtc tgatgcctcc     8520

cgtgggcagt caggatccag aagtgcaagc agaacaacac gtaatgagga acaatcagga     8580

gacggctcca ggcactcagg gtcgcgtcac catgaagctt ccactcatgc cgacatctct     8640

agacactcac aggcagtcca gggacaatca gaggggtcca ggagaagcag gcgccaggga     8700

tccagtgtga gccaggacag tgacagtgag ggacattcag aagactctga gaggtggtct     8760

gggtctgctt ccagaaacca tcatggatct gctcaggagc agctaagaga tggctccaga     8820

caccccaggt cccatcaaga agacagagct ggtcatgggc actctgcaga cagctccaga     8880

caatcaggca ctcgtcacac acagacttcc tctggtggac aggctgcatc atcccatgaa     8940

caggcaagat caagtgcagg agaaagacat ggatcccacc accagcagtc agcagacagc     9000

tccagacact caggcattgg gcacggacaa gcttcatctg cagtcagaga cagtggacac     9060

cgagggtaca gtggtagtca ggccagtgac aatgagggac attcagaaga ctcagacaca     9120

cagtcagtgt cagcccacgg acaggctggg tcccatcagc agagccacca agagtccgca     9180

cgtggccggt caggggaaac gtctggacat tcaggatctt tcctctacca ggtgagcact     9240

catgaacagt ctgagtcctc ccatggatgg acggggccca gcactagagg aagacaagga     9300

tcccgccatg agcaggcaca agacagctcc aggcactcag catcccaata cggtcaggac     9360

accattcgtg gacacccggg gtcaagcaga ggaggaaggc aggggtacca ccacgagcat     9420

tcggtagata gctctggaca ctcagggtcc catcacagcc acaccacatc ccagggaagg     9480

tctgatgcct cccgtgggca gtcaggatcc agaagtgcaa gcagaacaac acgtaatgag     9540

gaacaatcag gagacagctc caggcactca gtgtcacgtc accatgaagc ttccactcat     9600

gccgacatct ctagacactc acaggcagtc cagggacaat cagaggggtc caggagaagc     9660

aggcgccagg gatccagtgt gagccaggac agtgacagtg agggacattc agaagactct     9720

gagaggtggt ctgggtctgc ttccagaaac catcgtggat ctgttcagga gcagtcaagg     9780

cacggctcca gacaccccag gtcccatcac gaagacagag ccggtcacgg gcactctgca     9840

gaccgctcca gacaatcagg cactcgtcac gcagagactt cctctggtgg acaggctgca     9900

tcatcccatg aacaggcaag atcaagtcca ggagagagac acggatcccg ccaccagcag     9960

tcagcagaca gctccagaca ctcaggcatt ccgcgtggac aagcttcatc tgcagtcaga    10020

gacagtagac actgggggtc cagtggtagt caggccagtg atagtgaggg acattcagaa    10080

gagtcagaca cacagtcagt gtcaggccat ggacaggctg ggccccatca gcagagccac    10140

caagagtccg cacgtgaccg gtcaggggga aggtctggac gttcagggtc tttcctctac    10200

caggtgagca ctcatgaaca gtctgagtct gcccatgggc ggaccaggac cagcactgga    10260

cgaagacaag gatcccacca cgagcaggca cgagacagct ccaggcactc agcgtcccaa    10320

gagggtcagg acaccattcg tggacacccg gggtcaagca gaagaggaag gcagggatcc    10380

cactacgagc aatcggtaga taggtctgga cactcagggt cccatcacag ccacaccaca    10440

tcccagggaa ggtctgatgc ctcccgtggg cagtcaggat ccagaagtgc cagcagacaa    10500

actcgtaatg acgaacaatc aggagatggc tccaggcact catggtcgca tcaccatgaa    10560

gcttccactc aggcggacag ctctagacac tcacagtccg gccagggaca atcagcgggg    10620

cccaggacaa gcaggaacca gggatccagt gttagccagg acagtgacag tcagggacac    10680

tcagaagact ctgagaggtg gtctgggtct gcttccagaa accatcgtgg atctgctcag    10740

gagcagtcaa gagatggctc cagacacccc acgtcccatc acgaagacag agccggtcac    10800

gggcactctg cagagagctc cagacaatca ggcactcatc atgcagagaa ttcctctggt    10860

ggacaggctg catcatccca tgaacaggca agatcaagtg caggagagag acatggatcc    10920

caccaccagc agtcagcaga cagctccaga cactcaggca ttgggcacgg acaagcttca    10980

tctgcagtca gagacagtgg acaccgaggg tccagtggta gtcaggccag tgacagtgag    11040

ggacattcag aagactcaga cacacagtca gtgtcagccc acggacaggc tgggccccat    11100

cagcagagcc accaagagtc cacacgtggc cggtcagcag gaaggtctgg acgttcaggg    11160

tctttcctct accaggtgag cactcatgaa cagtctgagt ctgcccatgg acgggctggg    11220

cccagtactg gaggaagaca aggatcccgc cacgagcagg cacgagacag ctccaggcac    11280

tcagcgtccc aagagggtca ggacaccatt cgtggacacc cggggtcaag gagaggagga    11340

agacagggat cctaccacga gcaatcggta gataggtctg gacactcagg gtcccatcac    11400

agccacacca catcccaggg aaggtctgat gcctcccatg ggcagtcagg atccagaagt    11460

gcaagcagag aaacacgtaa tgaggaacag tcaggagacg gctccaggca ctcagggtcg    11520

cgtcaccatg aagcttccac tcaggctgac agctctagac actcacagtc cggccagggt    11580

gaatcagcgg ggtccaggag aagcaggcgc cagggatcca gtgttagcca ggacagtgac    11640

agtgaggcat acccagagga ctctgagagg cgatctgagt ctgcttccag aaaccatcat    11700

ggatcttctc gggagcagtc aagagatggc tccagacacc ccggatcctc tcaccgcgat    11760

acagccagtc atgtacagtc ttcacctgta cagtcagact ctagtaccgc taaggaacat    11820

ggtcacttta gtagtctttc acaagattct gcgtatcact caggaataca gtcacgtggc    11880

agtcctcaca gttctagttc ttatcattat caatctgagg gcactgaaag gcaaaaaggt    11940

caatcaggtt tagtttggag acatggcagc tatggtagtg cagattatga ttatggtgaa    12000

tccgggttta gacactctca gcacggaagt gttagttaca attccaatcc tgttgttttc    12060

aaggaaagat ctgatatctg taaagcaagt gcgtttggta aagatcatcc aaggtattat    12120

gcaacgtata ttaataagga cccaggttta tgtggccatt ctagtgatat atcgaaacaa    12180

ctgggattta gtcagtcaca gagatactat tactatgagt aagaaattaa tggcaaagga    12240

attaatccaa gaatagaaga atgaagcaag ttcactttca atcaagaaac ttcataatac    12300

tttcagggaa gttatctttt cctgtcaatc tgtttaaaat atgctatagt atttcattag    12360

tttggtggta gcttattttt attgtgtaat gatctttaaa cgctatattt cagaaatatt    12420

aaatggaaga aatcaatatc atggagagct aactttagaa aactagctgg agtattttag    12480

gagattctgg gtcaagtaat gttttatgtt tttgaaagtt taagttttag acactcccca    12540

aatttctaaa ttaatctttt tcagaaatat cgaaggagcc aaaaatataa aacagttctg    12600

tataccaaag tggctatatc aacatcaggg ctagcacatc tttctctatt atccttctat    12660

tggaattcta gtattctgta ttcaaaaaat catcttggac ataattaata ttatagtaag    12720

ctgcatctaa attaaaaata aactatt                                        12747


<210>  16
<211>  4061
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Gly Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His His Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Gly His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Leu Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu Arg Ser Gly Arg 
    450                 455                 460                 


Ser Gly Ser Ser Leu Tyr Gln Val Ser Thr His Glu Gln Pro Asp Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Ser Val Asn Arg Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly 
545                 550                 555                 560 


Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln 
                565                 570                 575     


Ser Gly Asp Gly Thr Arg His Ser Gly Ser Arg His His Glu Ala Ser 
            580                 585                 590         


Ser Gln Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser 
        595                 600                 605             


Ser Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly 
                645                 650                 655     


Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His 
            660                 665                 670         


Ser Ala Asp Ser Ser Arg Lys Ser Gly Thr Arg His Thr Gln Asn Ser 
        675                 680                 685             


Ser Ser Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala 
    690                 695                 700                 


Gly Glu Arg His Gly Ser Arg His Gln Leu Gln Ser Ala Asp Ser Ser 
705                 710                 715                 720 


Arg His Ser Gly Thr Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp 
                725                 730                 735     


Ser Gly His Arg Gly Ser Ser Gly Ser Gln Ala Thr Asp Ser Glu Gly 
            740                 745                 750         


His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala 
        755                 760                 765             


Gly His His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly 
    770                 775                 780                 


Glu Arg Ser Arg Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His 
785                 790                 795                 800 


Lys Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Gly Val 
                805                 810                 815     


Arg Gln Gly Ser His His Glu Gln Ala Arg Asp Asn Ser Arg His Ser 
            820                 825                 830         


Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser 
        835                 840                 845             


Arg Arg Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser 
    850                 855                 860                 


Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser 
865                 870                 875                 880 


Asp Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr 
                885                 890                 895     


Arg Asn Glu Glu Gln Ser Arg Asp Gly Ser Arg His Ser Gly Ser Arg 
            900                 905                 910         


His His Glu Ala Ser Ser His Ala Asp Ile Ser Arg His Ser Gln Ala 
        915                 920                 925             


Gly Gln Gly Gln Ser Glu Gly Ser Arg Thr Ser Arg Arg Gln Gly Ser 
    930                 935                 940                 


Ser Val Ser Gln Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu 
945                 950                 955                 960 


Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu 
                965                 970                 975     


Gln Ser Arg His Gly Ser Arg His Pro Arg Ser His His Glu Asp Arg 
            980                 985                 990         


Ala Gly His Gly His Ser Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Pro 
        995                 1000                 1005             


His Ala  Glu Thr Ser Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu 
    1010                 1015                 1020             


Gln Ala  Arg Ser Ser Pro Gly  Glu Arg His Gly Ser  Arg His Gln 
    1025                 1030                 1035             


Gln Ser  Ala Asp Ser Ser Arg  His Ser Gly Ile Pro  Arg Arg Gln 
    1040                 1045                 1050             


Ala Ser  Ser Ala Val Arg Asp  Ser Gly His Trp Gly  Ser Ser Gly 
    1055                 1060                 1065             


Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser Glu Glu  Ser Asp Thr 
    1070                 1075                 1080             


Gln Ser  Val Ser Gly His Gly  Gln Asp Gly Pro His  Gln Gln Ser 
    1085                 1090                 1095             


His Gln  Glu Ser Ala Arg Asp  Trp Ser Gly Gly Arg  Ser Gly Arg 
    1100                 1105                 1110             


Ser Gly  Ser Phe Ile Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu 
    1115                 1120                 1125             


Ser Ala  His Gly Arg Thr Arg  Thr Ser Thr Gly Arg  Arg Gln Gly 
    1130                 1135                 1140             


Ser His  His Glu Gln Ala Arg  Asp Ser Ser Arg His  Ser Ala Ser 
    1145                 1150                 1155             


Gln Glu  Gly Gln Asp Thr Ile  Arg Ala His Pro Gly  Ser Arg Arg 
    1160                 1165                 1170             


Gly Gly  Arg Gln Gly Ser His  His Glu Gln Ser Val  Asp Arg Ser 
    1175                 1180                 1185             


Gly His  Ser Gly Ser His His  Ser His Thr Thr Ser  Gln Gly Arg 
    1190                 1195                 1200             


Ser Asp  Ala Ser His Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg 
    1205                 1210                 1215             


Gln Thr  Arg Lys Asp Lys Gln  Ser Gly Asp Gly Ser  Arg His Ser 
    1220                 1225                 1230             


Gly Ser  Arg His His Glu Ala  Ala Ser Trp Ala Asp  Ser Ser Arg 
    1235                 1240                 1245             


His Ser  Gln Val Gly Gln Glu  Gln Ser Ser Gly Ser  Arg Thr Ser 
    1250                 1255                 1260             


Arg His  Gln Gly Ser Ser Val  Ser Gln Asp Ser Asp  Ser Glu Arg 
    1265                 1270                 1275             


His Ser  Asp Asp Ser Glu Arg  Leu Ser Gly Ser Ala  Ser Arg Asn 
    1280                 1285                 1290             


His His  Gly Ser Ser Arg Glu  Gln Ser Arg Asp Gly  Ser Arg His 
    1295                 1300                 1305             


Pro Gly  Phe His Gln Glu Asp  Arg Ala Ser His Gly  His Ser Ala 
    1310                 1315                 1320             


Asp Ser  Ser Arg Gln Ser Gly  Thr His His Thr Glu  Ser Ser Ser 
    1325                 1330                 1335             


His Gly  Gln Ala Val Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro 
    1340                 1345                 1350             


Gly Glu  Arg His Gly Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser 
    1355                 1360                 1365             


Arg His  Ser Gly Ile Gly His  Arg Gln Ala Ser Ser  Ala Val Arg 
    1370                 1375                 1380             


Asp Ser  Gly His Arg Gly Ser  Ser Gly Ser Gln Val  Thr Asn Ser 
    1385                 1390                 1395             


Glu Gly  His Ser Glu Asp Ser  Asp Thr Gln Ser Val  Ser Ala His 
    1400                 1405                 1410             


Gly Gln  Ala Gly Pro His Gln  Gln Ser His Lys Glu  Ser Ala Arg 
    1415                 1420                 1425             


Gly Gln  Ser Gly Glu Ser Ser  Gly Arg Ser Arg Ser  Phe Leu Tyr 
    1430                 1435                 1440             


Gln Val  Ser Ser His Glu Gln  Ser Glu Ser Thr His  Gly Gln Thr 
    1445                 1450                 1455             


Ala Pro  Ser Thr Gly Gly Arg  Gln Gly Ser Arg His  Glu Gln Ala 
    1460                 1465                 1470             


Arg Asn  Ser Ser Arg His Ser  Ala Ser Gln Asp Gly  Gln Asp Thr 
    1475                 1480                 1485             


Ile Arg  Gly His Pro Gly Ser  Ser Arg Gly Gly Arg  Gln Gly Ser 
    1490                 1495                 1500             


Tyr His  Glu Gln Ser Val Asp  Arg Ser Gly His Ser  Gly Tyr His 
    1505                 1510                 1515             


His Ser  His Thr Thr Pro Gln  Gly Arg Ser Asp Ala  Ser His Gly 
    1520                 1525                 1530             


Gln Ser  Gly Pro Arg Ser Ala  Ser Arg Gln Thr Arg  Asn Glu Glu 
    1535                 1540                 1545             


Gln Ser  Gly Asp Gly Ser Arg  His Ser Gly Ser Arg  His His Glu 
    1550                 1555                 1560             


Pro Ser  Thr Arg Ala Gly Ser  Ser Arg His Ser Gln  Val Gly Gln 
    1565                 1570                 1575             


Gly Glu  Ser Ala Gly Ser Lys  Thr Ser Arg Arg Gln  Gly Ser Ser 
    1580                 1585                 1590             


Val Ser  Gln Asp Arg Asp Ser  Glu Gly His Ser Glu  Asp Ser Glu 
    1595                 1600                 1605             


Arg Arg  Ser Glu Ser Ala Ser  Arg Asn His Tyr Gly  Ser Ala Arg 
    1610                 1615                 1620             


Glu Gln  Ser Arg His Gly Ser  Arg Asn Pro Arg Ser  His Gln Glu 
    1625                 1630                 1635             


Asp Arg  Ala Ser His Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser 
    1640                 1645                 1650             


Gly Thr  Arg His Ala Glu Thr  Ser Ser Gly Gly Gln  Ala Ala Ser 
    1655                 1660                 1665             


Ser Gln  Glu Gln Ala Arg Ser  Ser Pro Gly Glu Arg  His Gly Ser 
    1670                 1675                 1680             


Arg His  Gln Gln Ser Ala Asp  Ser Ser Thr Asp Ser  Gly Thr Gly 
    1685                 1690                 1695             


Arg Arg  Gln Asp Ser Ser Val  Val Gly Asp Ser Gly  Asn Arg Gly 
    1700                 1705                 1710             


Ser Ser  Gly Ser Gln Ala Ser  Asp Ser Glu Gly His  Ser Glu Glu 
    1715                 1720                 1725             


Ser Asp  Thr Gln Ser Val Ser  Ala His Gly Gln Ala  Gly Pro His 
    1730                 1735                 1740             


Gln Gln  Ser His Gln Glu Ser  Thr Arg Gly Gln Ser  Gly Glu Arg 
    1745                 1750                 1755             


Ser Gly  Arg Ser Gly Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu 
    1760                 1765                 1770             


Gln Ser  Glu Ser Ala His Gly  Arg Thr Gly Pro Ser  Thr Gly Gly 
    1775                 1780                 1785             


Arg Gln  Arg Ser Arg His Glu  Gln Ala Arg Asp Ser  Ser Arg His 
    1790                 1795                 1800             


Ser Ala  Ser Gln Glu Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly 
    1805                 1810                 1815             


Ser Ser  Arg Gly Gly Arg Gln  Gly Ser His Tyr Glu  Gln Ser Val 
    1820                 1825                 1830             


Asp Ser  Ser Gly His Ser Gly  Ser His His Ser His  Thr Thr Ser 
    1835                 1840                 1845             


Gln Glu  Arg Ser Asp Val Ser  Arg Gly Gln Ser Gly  Ser Arg Ser 
    1850                 1855                 1860             


Val Ser  Arg Gln Thr Arg Asn  Glu Lys Gln Ser Gly  Asp Gly Ser 
    1865                 1870                 1875             


Arg His  Ser Gly Ser Arg His  His Glu Ala Ser Ser  Arg Ala Asp 
    1880                 1885                 1890             


Ser Ser  Arg His Ser Gln Val  Gly Gln Gly Gln Ser  Ser Gly Pro 
    1895                 1900                 1905             


Arg Thr  Ser Arg Asn Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp 
    1910                 1915                 1920             


Ser Gln  Gly His Ser Glu Asp  Ser Glu Arg Trp Ser  Gly Ser Ala 
    1925                 1930                 1935             


Ser Arg  Asn His Leu Gly Ser  Ala Trp Glu Gln Ser  Arg Asp Gly 
    1940                 1945                 1950             


Ser Arg  His Pro Gly Ser His  His Glu Asp Arg Ala  Gly His Gly 
    1955                 1960                 1965             


His Ser  Ala Asp Ser Ser Arg  Gln Ser Gly Thr Arg  His Thr Glu 
    1970                 1975                 1980             


Ser Ser  Ser Arg Gly Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg 
    1985                 1990                 1995             


Ser Ser  Ala Gly Glu Arg His  Gly Ser His His Gln  Leu Gln Ser 
    2000                 2005                 2010             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    2015                 2020                 2025             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Tyr Ser  Gly Ser Gln 
    2030                 2035                 2040             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    2045                 2050                 2055             


Val Ser  Ala Gln Gly Lys Ala  Gly Pro His Gln Gln  Ser His Lys 
    2060                 2065                 2070             


Glu Ser  Ala Arg Gly Gln Ser  Gly Glu Ser Ser Gly  Arg Ser Gly 
    2075                 2080                 2085             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Thr 
    2090                 2095                 2100             


His Gly  Gln Ser Ala Pro Ser  Thr Gly Gly Arg Gln  Gly Ser His 
    2105                 2110                 2115             


Tyr Asp  Gln Ala Gln Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    2120                 2125                 2130             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Pro Ser  Arg Gly Gly 
    2135                 2140                 2145             


Arg Gln  Gly Ser His Gln Glu  Gln Ser Val Asp Arg  Ser Gly His 
    2150                 2155                 2160             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    2165                 2170                 2175             


Ala Ser  Arg Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Lys Thr 
    2180                 2185                 2190             


Tyr Asp  Lys Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    2195                 2200                 2205             


His His  His Glu Ala Ser Ser  Trp Ala Asp Ser Ser  Arg His Ser 
    2210                 2215                 2220             


Leu Val  Gly Gln Gly Gln Ser  Ser Gly Pro Arg Thr  Ser Arg Pro 
    2225                 2230                 2235             


Arg Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Gly His Ser 
    2240                 2245                 2250             


Glu Asp  Ser Glu Arg Arg Ser  Gly Ser Ala Ser Arg  Asn His His 
    2255                 2260                 2265             


Gly Ser  Ala Gln Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Arg 
    2270                 2275                 2280             


Ser His  His Glu Asp Arg Ala  Gly His Gly His Ser  Ala Glu Ser 
    2285                 2290                 2295             


Ser Arg  Gln Ser Gly Thr His  His Ala Glu Asn Ser  Ser Gly Gly 
    2300                 2305                 2310             


Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg Ser Ser  Ala Gly Glu 
    2315                 2320                 2325             


Arg His  Gly Ser His His Gln  Gln Ser Ala Asp Ser  Ser Arg His 
    2330                 2335                 2340             


Ser Gly  Ile Gly His Gly Gln  Ala Ser Ser Ala Val  Arg Asp Ser 
    2345                 2350                 2355             


Gly His  Arg Gly Ser Ser Gly  Ser Gln Ala Ser Asp  Ser Glu Gly 
    2360                 2365                 2370             


His Ser  Glu Asp Ser Asp Thr  Gln Ser Val Ser Ala  His Gly Gln 
    2375                 2380                 2385             


Ala Gly  Pro His Gln Gln Ser  His Gln Glu Ser Thr  Arg Gly Arg 
    2390                 2395                 2400             


Ser Ala  Gly Arg Ser Gly Arg  Ser Gly Ser Phe Leu  Tyr Gln Val 
    2405                 2410                 2415             


Ser Thr  His Glu Gln Ser Glu  Ser Ala His Gly Arg  Thr Gly Thr 
    2420                 2425                 2430             


Ser Thr  Gly Gly Arg Gln Gly  Ser His His Lys Gln  Ala Arg Asp 
    2435                 2440                 2445             


Ser Ser  Arg His Ser Thr Ser  Gln Glu Gly Gln Asp  Thr Ile His 
    2450                 2455                 2460             


Gly His  Pro Gly Ser Ser Ser  Gly Gly Arg Gln Gly  Ser His Tyr 
    2465                 2470                 2475             


Glu Gln  Leu Val Asp Arg Ser  Gly His Ser Gly Ser  His His Ser 
    2480                 2485                 2490             


His Thr  Thr Ser Gln Gly Arg  Ser Asp Ala Ser His  Gly His Ser 
    2495                 2500                 2505             


Gly Ser  Arg Ser Ala Ser Arg  Gln Thr Arg Asn Asp  Glu Gln Ser 
    2510                 2515                 2520             


Gly Asp  Gly Ser Arg His Ser  Gly Ser Arg His His  Glu Ala Ser 
    2525                 2530                 2535             


Ser Arg  Ala Asp Ser Ser Gly  His Ser Gln Val Gly  Gln Gly Gln 
    2540                 2545                 2550             


Ser Glu  Gly Pro Arg Thr Ser  Arg Asn Trp Gly Ser  Ser Phe Ser 
    2555                 2560                 2565             


Gln Asp  Ser Asp Ser Gln Gly  His Ser Glu Asp Ser  Glu Arg Trp 
    2570                 2575                 2580             


Ser Gly  Ser Ala Ser Arg Asn  His His Gly Ser Ala  Gln Glu Gln 
    2585                 2590                 2595             


Leu Arg  Asp Gly Ser Arg His  Pro Arg Ser His Gln  Glu Asp Arg 
    2600                 2605                 2610             


Ala Gly  His Gly His Ser Ala  Asp Ser Ser Arg Gln  Ser Gly Thr 
    2615                 2620                 2625             


Arg His  Thr Gln Thr Ser Ser  Gly Gly Gln Ala Ala  Ser Ser His 
    2630                 2635                 2640             


Glu Gln  Ala Arg Ser Ser Ala  Gly Glu Arg His Gly  Ser His His 
    2645                 2650                 2655             


Gln Gln  Ser Ala Asp Ser Ser  Arg His Ser Gly Ile  Gly His Gly 
    2660                 2665                 2670             


Gln Ala  Ser Ser Ala Val Arg  Asp Ser Gly His Arg  Gly Tyr Ser 
    2675                 2680                 2685             


Gly Ser  Gln Ala Ser Asp Asn  Glu Gly His Ser Glu  Asp Ser Asp 
    2690                 2695                 2700             


Thr Gln  Ser Val Ser Ala His  Gly Gln Ala Gly Ser  His Gln Gln 
    2705                 2710                 2715             


Ser His  Gln Glu Ser Ala Arg  Gly Arg Ser Gly Glu  Thr Ser Gly 
    2720                 2725                 2730             


His Ser  Gly Ser Phe Leu Tyr  Gln Val Ser Thr His  Glu Gln Ser 
    2735                 2740                 2745             


Glu Ser  Ser His Gly Trp Thr  Gly Pro Ser Thr Arg  Gly Arg Gln 
    2750                 2755                 2760             


Gly Ser  Arg His Glu Gln Ala  Gln Asp Ser Ser Arg  His Ser Ala 
    2765                 2770                 2775             


Ser Gln  Asp Gly Gln Asp Thr  Ile Arg Gly His Pro  Gly Ser Ser 
    2780                 2785                 2790             


Arg Gly  Gly Arg Gln Gly Tyr  His His Glu His Ser  Val Asp Ser 
    2795                 2800                 2805             


Ser Gly  His Ser Gly Ser His  His Ser His Thr Thr  Ser Gln Gly 
    2810                 2815                 2820             


Arg Ser  Asp Ala Ser Arg Gly  Gln Ser Gly Ser Arg  Ser Ala Ser 
    2825                 2830                 2835             


Arg Thr  Thr Arg Asn Glu Glu  Gln Ser Gly Asp Gly  Ser Arg His 
    2840                 2845                 2850             


Ser Gly  Ser Arg His His Glu  Ala Ser Thr His Ala  Asp Ile Ser 
    2855                 2860                 2865             


Arg His  Ser Gln Ala Val Gln  Gly Gln Ser Glu Gly  Ser Arg Arg 
    2870                 2875                 2880             


Ser Arg  Arg Gln Gly Ser Ser  Val Ser Gln Asp Ser  Asp Ser Glu 
    2885                 2890                 2895             


Gly His  Ser Glu Asp Ser Glu  Arg Trp Ser Gly Ser  Ala Ser Arg 
    2900                 2905                 2910             


Asn His  His Gly Ser Ala Gln  Glu Gln Leu Arg Asp  Gly Ser Arg 
    2915                 2920                 2925             


His Pro  Arg Ser His Gln Glu  Asp Arg Ala Gly His  Gly His Ser 
    2930                 2935                 2940             


Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Arg His Thr  Gln Thr Ser 
    2945                 2950                 2955             


Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu Gln Ala  Arg Ser Ser 
    2960                 2965                 2970             


Ala Gly  Glu Arg His Gly Ser  His His Gln Gln Ser  Ala Asp Ser 
    2975                 2980                 2985             


Ser Arg  His Ser Gly Ile Gly  His Gly Gln Ala Ser  Ser Ala Val 
    2990                 2995                 3000             


Arg Asp  Ser Gly His Arg Gly  Tyr Ser Gly Ser Gln  Ala Ser Asp 
    3005                 3010                 3015             


Asn Glu  Gly His Ser Glu Asp  Ser Asp Thr Gln Ser  Val Ser Ala 
    3020                 3025                 3030             


His Gly  Gln Ala Gly Ser His  Gln Gln Ser His Gln  Glu Ser Ala 
    3035                 3040                 3045             


Arg Gly  Arg Ser Gly Glu Thr  Ser Gly His Ser Gly  Ser Phe Leu 
    3050                 3055                 3060             


Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu Ser Ser  His Gly Trp 
    3065                 3070                 3075             


Thr Gly  Pro Ser Thr Arg Gly  Arg Gln Gly Ser Arg  His Glu Gln 
    3080                 3085                 3090             


Ala Gln  Asp Ser Ser Arg His  Ser Ala Ser Gln Tyr  Gly Gln Asp 
    3095                 3100                 3105             


Thr Ile  Arg Gly His Pro Gly  Ser Ser Arg Gly Gly  Arg Gln Gly 
    3110                 3115                 3120             


Tyr His  His Glu His Ser Val  Asp Ser Ser Gly His  Ser Gly Ser 
    3125                 3130                 3135             


His His  Ser His Thr Thr Ser  Gln Gly Arg Ser Asp  Ala Ser Arg 
    3140                 3145                 3150             


Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg Thr Thr  Arg Asn Glu 
    3155                 3160                 3165             


Glu Gln  Ser Gly Asp Ser Ser  Arg His Ser Val Ser  Arg His His 
    3170                 3175                 3180             


Glu Ala  Ser Thr His Ala Asp  Ile Ser Arg His Ser  Gln Ala Val 
    3185                 3190                 3195             


Gln Gly  Gln Ser Glu Gly Ser  Arg Arg Ser Arg Arg  Gln Gly Ser 
    3200                 3205                 3210             


Ser Val  Ser Gln Asp Ser Asp  Ser Glu Gly His Ser  Glu Asp Ser 
    3215                 3220                 3225             


Glu Arg  Trp Ser Gly Ser Ala  Ser Arg Asn His Arg  Gly Ser Val 
    3230                 3235                 3240             


Gln Glu  Gln Ser Arg His Gly  Ser Arg His Pro Arg  Ser His His 
    3245                 3250                 3255             


Glu Asp  Arg Ala Gly His Gly  His Ser Ala Asp Arg  Ser Arg Gln 
    3260                 3265                 3270             


Ser Gly  Thr Arg His Ala Glu  Thr Ser Ser Gly Gly  Gln Ala Ala 
    3275                 3280                 3285             


Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro Gly Glu  Arg His Gly 
    3290                 3295                 3300             


Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser Arg His  Ser Gly Ile 
    3305                 3310                 3315             


Pro Arg  Gly Gln Ala Ser Ser  Ala Val Arg Asp Ser  Arg His Trp 
    3320                 3325                 3330             


Gly Ser  Ser Gly Ser Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu 
    3335                 3340                 3345             


Glu Ser  Asp Thr Gln Ser Val  Ser Gly His Gly Gln  Ala Gly Pro 
    3350                 3355                 3360             


His Gln  Gln Ser His Gln Glu  Ser Ala Arg Asp Arg  Ser Gly Gly 
    3365                 3370                 3375             


Arg Ser  Gly Arg Ser Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His 
    3380                 3385                 3390             


Glu Gln  Ser Glu Ser Ala His  Gly Arg Thr Arg Thr  Ser Thr Gly 
    3395                 3400                 3405             


Arg Arg  Gln Gly Ser His His  Glu Gln Ala Arg Asp  Ser Ser Arg 
    3410                 3415                 3420             


His Ser  Ala Ser Gln Glu Gly  Gln Asp Thr Ile Arg  Gly His Pro 
    3425                 3430                 3435             


Gly Ser  Ser Arg Arg Gly Arg  Gln Gly Ser His Tyr  Glu Gln Ser 
    3440                 3445                 3450             


Val Asp  Arg Ser Gly His Ser  Gly Ser His His Ser  His Thr Thr 
    3455                 3460                 3465             


Ser Gln  Gly Arg Ser Asp Ala  Ser Arg Gly Gln Ser  Gly Ser Arg 
    3470                 3475                 3480             


Ser Ala  Ser Arg Gln Thr Arg  Asn Asp Glu Gln Ser  Gly Asp Gly 
    3485                 3490                 3495             


Ser Arg  His Ser Trp Ser His  His His Glu Ala Ser  Thr Gln Ala 
    3500                 3505                 3510             


Asp Ser  Ser Arg His Ser Gln  Ser Gly Gln Gly Gln  Ser Ala Gly 
    3515                 3520                 3525             


Pro Arg  Thr Ser Arg Asn Gln  Gly Ser Ser Val Ser  Gln Asp Ser 
    3530                 3535                 3540             


Asp Ser  Gln Gly His Ser Glu  Asp Ser Glu Arg Trp  Ser Gly Ser 
    3545                 3550                 3555             


Ala Ser  Arg Asn His Arg Gly  Ser Ala Gln Glu Gln  Ser Arg Asp 
    3560                 3565                 3570             


Gly Ser  Arg His Pro Thr Ser  His His Glu Asp Arg  Ala Gly His 
    3575                 3580                 3585             


Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser Gly Thr  His His Ala 
    3590                 3595                 3600             


Glu Asn  Ser Ser Gly Gly Gln  Ala Ala Ser Ser His  Glu Gln Ala 
    3605                 3610                 3615             


Arg Ser  Ser Ala Gly Glu Arg  His Gly Ser His His  Gln Gln Ser 
    3620                 3625                 3630             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    3635                 3640                 3645             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Ser Ser  Gly Ser Gln 
    3650                 3655                 3660             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    3665                 3670                 3675             


Val Ser  Ala His Gly Gln Ala  Gly Pro His Gln Gln  Ser His Gln 
    3680                 3685                 3690             


Glu Ser  Thr Arg Gly Arg Ser  Ala Gly Arg Ser Gly  Arg Ser Gly 
    3695                 3700                 3705             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Ala 
    3710                 3715                 3720             


His Gly  Arg Ala Gly Pro Ser  Thr Gly Gly Arg Gln  Gly Ser Arg 
    3725                 3730                 3735             


His Glu  Gln Ala Arg Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    3740                 3745                 3750             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Ser Arg  Arg Gly Gly 
    3755                 3760                 3765             


Arg Gln  Gly Ser Tyr His Glu  Gln Ser Val Asp Arg  Ser Gly His 
    3770                 3775                 3780             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    3785                 3790                 3795             


Ala Ser  His Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Glu Thr 
    3800                 3805                 3810             


Arg Asn  Glu Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    3815                 3820                 3825             


Arg His  His Glu Ala Ser Thr  Gln Ala Asp Ser Ser  Arg His Ser 
    3830                 3835                 3840             


Gln Ser  Gly Gln Gly Glu Ser  Ala Gly Ser Arg Arg  Ser Arg Arg 
    3845                 3850                 3855             


Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Ala Tyr Pro 
    3860                 3865                 3870             


Glu Asp  Ser Glu Arg Arg Ser  Glu Ser Ala Ser Arg  Asn His His 
    3875                 3880                 3885             


Gly Ser  Ser Arg Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Gly 
    3890                 3895                 3900             


Ser Ser  His Arg Asp Thr Ala  Ser His Val Gln Ser  Ser Pro Val 
    3905                 3910                 3915             


Gln Ser  Asp Ser Ser Thr Ala  Lys Glu His Gly His  Phe Ser Ser 
    3920                 3925                 3930             


Leu Ser  Gln Asp Ser Ala Tyr  His Ser Gly Ile Gln  Ser Arg Gly 
    3935                 3940                 3945             


Ser Pro  His Ser Ser Ser Ser  Tyr His Tyr Gln Ser  Glu Gly Thr 
    3950                 3955                 3960             


Glu Arg  Gln Lys Gly Gln Ser  Gly Leu Val Trp Arg  His Gly Ser 
    3965                 3970                 3975             


Tyr Gly  Ser Ala Asp Tyr Asp  Tyr Gly Glu Ser Gly  Phe Arg His 
    3980                 3985                 3990             


Ser Gln  His Gly Ser Val Ser  Tyr Asn Ser Asn Pro  Val Val Phe 
    3995                 4000                 4005             


Lys Glu  Arg Ser Asp Ile Cys  Lys Ala Ser Ala Phe  Gly Lys Asp 
    4010                 4015                 4020             


His Pro  Arg Tyr Tyr Ala Thr  Tyr Ile Asn Lys Asp  Pro Gly Leu 
    4025                 4030                 4035             


Cys Gly  His Ser Ser Asp Ile  Ser Lys Gln Leu Gly  Phe Ser Gln 
    4040                 4045                 4050             


Ser Gln  Arg Tyr Tyr Tyr Tyr  Glu 
    4055                 4060     


<210>  17
<211>  537
<212>  DNA
<213>  Homo sapiens

<400>  17
ctctcatcac ttctgagcac ggagcaatgg cctctcgctg ggctgtgcag ctgctgctcg       60

tggcagcctg gagcatgggc tgtggtgagg ccctcaagtg ctacacctgc aaggagccca      120

tgaccagtgc ttcctgcagg accattaccc gctgcaagcc agaggacaca gcctgcatga      180

ccacgctggt gacggtggag gcagagtacc ccttcaacca gagccccgtg gtgacccgct      240

cctgctccag ctcctgtgtg gccaccgacc ccgacagcat cggggccgcc cacctgatct      300

tctgctgctt ccgagacctc tgcaactcgg aactctgaac ccagggcggc agggcggaag      360

gtgctcctca ggcacctcct ctctgacggg gcctggctcc acctgtgatc acctccccct      420

gcttcctgct gctgtggcac agctcactca tggggtctga ggggagagaa gcacaccagg      480

ggcgccctct gccttccata ccccacgctt ataaaacata actaagccaa gagtgga         537


<210>  18
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ser Arg Trp Ala Val Gln Leu Leu Leu Val Ala Ala Trp Ser 
1               5                   10                  15      


Met Gly Cys Gly Glu Ala Leu Lys Cys Tyr Thr Cys Lys Glu Pro Met 
            20                  25                  30          


Thr Ser Ala Ser Cys Arg Thr Ile Thr Arg Cys Lys Pro Glu Asp Thr 
        35                  40                  45              


Ala Cys Met Thr Thr Leu Val Thr Val Glu Ala Glu Tyr Pro Phe Asn 
    50                  55                  60                  


Gln Ser Pro Val Val Thr Arg Ser Cys Ser Ser Ser Cys Val Ala Thr 
65                  70                  75                  80  


Asp Pro Asp Ser Ile Gly Ala Ala His Leu Ile Phe Cys Cys Phe Arg 
                85                  90                  95      


Asp Leu Cys Asn Ser Glu Leu 
            100             


<210>  19
<211>  2219
<212>  DNA
<213>  Homo sapiens

<400>  19
gcacaaccag aatttgccaa aacaggaaat aggtgtttca tatatacggc tctaaccttc       60

tctctctgca ccttccttct gtcaatagat gaaacaaata cttcatcctg ctctggaaac      120

cactgcaatg acattattcc cagtgctgtt gttcctggtt gctgggctgc ttccatcttt      180

tccagcaaat gaagataagg atcccgcttt tactgctttg ttaaccaccc aaacacaagt      240

gcaaagggag attgtgaata agcacaatga actgaggaga gcagtatctc cccctgccag      300

aaacatgctg aagatggaat ggaacaaaga ggctgcagca aatgcccaaa agtgggcaaa      360

ccagtgcaat tacagacaca gtaacccaaa ggatcgaatg acaagtctaa aatgtggtga      420

gaatctctac atgtcaagtg cctccagctc atggtcacaa gcaatccaaa gctggtttga      480

tgagtacaat gattttgact ttggtgtagg gccaaagact cccaacgcag tggttggaca      540

ttatacacag gttgtttggt actcttcata cctcgttgga tgtggaaatg cctactgtcc      600

caatcaaaaa gttctaaaat actactatgt ttgccaatat tgtcctgctg gtaattgggc      660

taatagacta tatgtccctt atgaacaagg agcaccttgt gccagttgcc cagataactg      720

tgacgatgga ctatgcacca atggttgcaa gtacgaagat ctctatagta actgtaaaag      780

tttgaagctc acattaacct gtaaacatca gttggtcagg gacagttgca aggcctcctg      840

caattgttca aacagcattt attaaatacg cattacacac cgagtagggc tatgtagaga      900

ggagtcagat tatctactta gatttggcat ctacttagat ttaacatata ctagctgaga      960

aattgtaggc atgtttgata cacatttgat ttcaaatgtt tttcttctgg atctgctttt     1020

tattttacaa aaatattttt catacaaatg gttaaaaaga aacaaaatct ataacaacaa     1080

ctttggattt ttatatataa actttgtgat ttaaatttac tgaatttaat tagggtgaaa     1140

attttgaaag ttgtattctc atatgactaa gttcactaaa accctggatt gaaagtgaaa     1200

attatgttcc tagaacaaaa tgtacaaaaa gaacaatata attttcacat gaacccttgg     1260

ctgtagttgc ctttcctagc tccactctaa ggctaagcat cttcaaagac gttttcccat     1320

atgctgtctt aattcttttc actcattcac ccttcttccc aatcatctgg ctggcatcct     1380

cacaattgag ttgaagctgt tcctcctaaa acaatcctga cttttatttt gccaaaatca     1440

atacaatcct ttgaattttt tatctgcata aattttacag tagaatatga tcaaaccttc     1500

atttttaaac ctctcttctc tttgacaaaa cttccttaaa aaagaataca agataatata     1560

ggtaaatacc ctccactcaa ggaggtagaa ctcagtcctc tcccttgtga gtcttcacta     1620

aaatcagtga ctcacttcca aagagtggag tatggaaagg gaaacatagt aactttacag     1680

gggagaaaaa tgacaaatga cgtcttcacc aagtgatcaa aattaacgtc accagtgata     1740

agtcattcag atttgttcta gataatcttt ctaaaaattc ataatcccaa tctaattatg     1800

agctaaaaca tccagcaaac tcaagttgaa ggacattcta caaaatatcc ctggggtatt     1860

ttagagtatt cctcaaaact gtaaaaatca tggaaaataa gggaatcctg agaaacaatc     1920

acagaccaca tgagactaag gagacatgtg agccaaatgc aatgtgcttc ttggatcaga     1980

tcctggaaca gaaaaagatc agtaatgaaa aaactgatga agtctgaata gaatctggag     2040

tatttttaac agtagtgttg atttcttaat cttgataaat atagcagggt aatgtaagat     2100

gataacgtta gagaaactga aactgggtga gggctatcta ggaattctct gtactatctt     2160

accaaatttt cggtaagtct aagaaagcaa tgcaaaataa aaagtgtctt gaaaaaaaa      2219


<210>  20
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Gln Ile Leu His Pro Ala Leu Glu Thr Thr Ala Met Thr Leu 
1               5                   10                  15      


Phe Pro Val Leu Leu Phe Leu Val Ala Gly Leu Leu Pro Ser Phe Pro 
            20                  25                  30          


Ala Asn Glu Asp Lys Asp Pro Ala Phe Thr Ala Leu Leu Thr Thr Gln 
        35                  40                  45              


Thr Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu Leu Arg Arg 
    50                  55                  60                  


Ala Val Ser Pro Pro Ala Arg Asn Met Leu Lys Met Glu Trp Asn Lys 
65                  70                  75                  80  


Glu Ala Ala Ala Asn Ala Gln Lys Trp Ala Asn Gln Cys Asn Tyr Arg 
                85                  90                  95      


His Ser Asn Pro Lys Asp Arg Met Thr Ser Leu Lys Cys Gly Glu Asn 
            100                 105                 110         


Leu Tyr Met Ser Ser Ala Ser Ser Ser Trp Ser Gln Ala Ile Gln Ser 
        115                 120                 125             


Trp Phe Asp Glu Tyr Asn Asp Phe Asp Phe Gly Val Gly Pro Lys Thr 
    130                 135                 140                 


Pro Asn Ala Val Val Gly His Tyr Thr Gln Val Val Trp Tyr Ser Ser 
145                 150                 155                 160 


Tyr Leu Val Gly Cys Gly Asn Ala Tyr Cys Pro Asn Gln Lys Val Leu 
                165                 170                 175     


Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn Trp Ala Asn 
            180                 185                 190         


Arg Leu Tyr Val Pro Tyr Glu Gln Gly Ala Pro Cys Ala Ser Cys Pro 
        195                 200                 205             


Asp Asn Cys Asp Asp Gly Leu Cys Thr Asn Gly Cys Lys Tyr Glu Asp 
    210                 215                 220                 


Leu Tyr Ser Asn Cys Lys Ser Leu Lys Leu Thr Leu Thr Cys Lys His 
225                 230                 235                 240 


Gln Leu Val Arg Asp Ser Cys Lys Ala Ser Cys Asn Cys Ser Asn Ser 
                245                 250                 255     


Ile Tyr 
        


