                         SEQUENCE LISTING

<110>  President and Fellows of Harvard College
       Sinclair, David A
       Gomes, Ana P
        
<120>  NAD BIOSYNTHESIS AND PRECURSORS IN THE PREVENTION AND TREATMENT OF INFLAMMATION

<130>  H0498.70476WO00

<140>  TBD
<141>  2013-10-09

<150>  US 61/832,204
<151>  2013-06-07

<150>  US 61/832,414
<151>  2013-06-07

<150>  US 61/711,552
<151>  2012-10-09

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  826
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                405                 410                 415     


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
465                 470                 475                 480 


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
            580                 585                 590         


Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln 
        595                 600                 605             


Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu 
    610                 615                 620                 


Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser 
                645                 650                 655     


Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala 
            660                 665                 670         


Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro 
        675                 680                 685             


Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu 
    690                 695                 700                 


Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg 
705                 710                 715                 720 


Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr 
                725                 730                 735     


Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp 
            740                 745                 750         


Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln 
        755                 760                 765             


Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly 
    770                 775                 780                 


Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys 
785                 790                 795                 800 


Glu Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu 
                805                 810                 815     


Glu Leu Leu Arg Ala Leu Asp Gln Val Asn 
            820                 825     


<210>  2
<211>  826
<212>  PRT
<213>  Pan troglodytes

<400>  2

Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                405                 410                 415     


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
465                 470                 475                 480 


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
            580                 585                 590         


Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln 
        595                 600                 605             


Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu 
    610                 615                 620                 


Lys Thr Val Thr Lys Asp Cys Met Glu Asp Ile Lys Ile Leu Ile Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser 
                645                 650                 655     


Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala 
            660                 665                 670         


Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro 
        675                 680                 685             


Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu 
    690                 695                 700                 


Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg 
705                 710                 715                 720 


Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr 
                725                 730                 735     


Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp 
            740                 745                 750         


Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln 
        755                 760                 765             


Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly 
    770                 775                 780                 


Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys 
785                 790                 795                 800 


Glu Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu 
                805                 810                 815     


Glu Leu Leu Arg Ala Leu Asp Gln Val Asn 
            820                 825     


<210>  3
<211>  826
<212>  PRT
<213>  Macaca mulatta

<400>  3

Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Asp Glu Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Pro Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                405                 410                 415     


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Leu Pro Ser Ser Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Thr Ser Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
465                 470                 475                 480 


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Pro Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
            580                 585                 590         


Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln 
        595                 600                 605             


Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu 
    610                 615                 620                 


Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala 
625                 630                 635                 640 


Ser Pro Ser Ser Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser 
                645                 650                 655     


Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala 
            660                 665                 670         


Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro 
        675                 680                 685             


Asn Val Leu Ser Val Thr Leu Ser Gln Arg Thr Thr Val Pro Glu Glu 
    690                 695                 700                 


Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg 
705                 710                 715                 720 


Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr 
                725                 730                 735     


Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp 
            740                 745                 750         


Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln 
        755                 760                 765             


Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly 
    770                 775                 780                 


Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys 
785                 790                 795                 800 


Glu Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu 
                805                 810                 815     


Glu Leu Leu Arg Ala Leu Asp Gln Val Asn 
            820                 825     


<210>  4
<211>  823
<212>  PRT
<213>  Canis lupus familiaris

<400>  4

Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Asp Glu Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Ser 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                405                 410                 415     


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Leu Pro Ser Ser Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Ala Ser Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
465                 470                 475                 480 


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Pro Ala Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Asp Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Asn Ser Thr Ser Pro Gln Ser 
            580                 585                 590         


Ala Ser Thr Ile Thr Val Phe Gln Pro Thr Pro Met Gln Glu Pro Pro 
        595                 600                 605             


Leu Thr Thr Thr Ser Thr Thr Ala Thr Thr Asp Glu Leu Lys Thr Val 
    610                 615                 620                 


Thr Lys Asp Gly Ile Glu Asp Ile Lys Ile Leu Ile Ala Ala Pro Ser 
625                 630                 635                 640 


Pro Thr His Val Pro Lys Val Thr Thr Ser Ala Thr Thr Ser Pro Tyr 
                645                 650                 655     


Ser Asp Thr Gly Ser Arg Thr Ala Ser Pro Asn Arg Ala Gly Lys Gly 
            660                 665                 670         


Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro Asn Val Leu 
        675                 680                 685             


Ser Val Thr Leu Ser Gln Arg Thr Thr Ile Pro Glu Glu Glu Leu Asn 
    690                 695                 700                 


Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg Lys Ile Glu 
705                 710                 715                 720 


His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr Leu Leu Gln 
                725                 730                 735     


Gln Pro Asp Asp Arg Ala Thr Thr Thr Ser Leu Ser Trp Lys Arg Val 
            740                 745                 750         


Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln Lys Thr Ile 
        755                 760                 765             


Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly Gln Ser Met 
    770                 775                 780                 


Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys Glu Val Asn 
785                 790                 795                 800 


Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu Glu Leu Leu 
                805                 810                 815     


Arg Ala Leu Asp Gln Val Asn 
            820             


<210>  5
<211>  823
<212>  PRT
<213>  Bos Taurus

<400>  5

Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Asp Glu Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Ser 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Ile Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                405                 410                 415     


Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Leu Pro Ser Ser Asn Glu Lys Leu Gln Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Ala Ser Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
465                 470                 475                 480 


Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Pro Ala Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Asp Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Asn Ser Ser Thr Ser Pro Gln Ser 
            580                 585                 590         


Ala Ser Thr Asn Thr Val Phe Gln Pro Thr Gln Met Gln Glu Pro Pro 
        595                 600                 605             


Ile Ala Thr Val Thr Thr Thr Ala Thr Ser Asp Glu Leu Lys Thr Val 
    610                 615                 620                 


Thr Lys Asp Gly Met Glu Asp Ile Lys Ile Leu Ile Ala Phe Pro Ser 
625                 630                 635                 640 


Pro Pro His Val Pro Lys Glu Pro Pro Cys Ala Thr Thr Ser Pro Tyr 
                645                 650                 655     


Ser Asp Thr Gly Ser Arg Thr Ala Ser Pro Asn Arg Ala Gly Lys Gly 
            660                 665                 670         


Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro Asn Val Leu 
        675                 680                 685             


Ser Val Ala Leu Ser Gln Arg Thr Thr Ala Pro Glu Glu Glu Leu Asn 
    690                 695                 700                 


Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg Lys Ile Glu 
705                 710                 715                 720 


His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr Leu Leu Gln 
                725                 730                 735     


Gln Pro Asp Asp Arg Ala Thr Thr Thr Ser Leu Ser Trp Lys Arg Val 
            740                 745                 750         


Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln Lys Thr Ile 
        755                 760                 765             


Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly Gln Ser Met 
    770                 775                 780                 


Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys Glu Val Asn 
785                 790                 795                 800 


Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu Glu Leu Leu 
                805                 810                 815     


Arg Ala Leu Asp Gln Val Asn 
            820             


<210>  6
<211>  836
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Gly Ala Gly Gly Glu Asn Glu Lys Lys Lys Met Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Gly Leu Asp Ser 
65                  70                  75                  80  


Glu Asp Glu Met Lys Ala Gln Met Asp Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Val Tyr Ile 
            100                 105                 110         


Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Pro Val Arg Lys Gly Lys Glu 
145                 150                 155                 160 


Leu Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro 
        195                 200                 205             


Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gln Gln Thr Glu Ser Val Leu Lys Pro Val Glu Ser Ser Asp 
        355                 360                 365             


Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
    370                 375                 380                 


Cys Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asp 
                405                 410                 415     


Asp Thr Glu Thr Glu Asp Gln Gln Leu Glu Asp Val Pro Leu Tyr Asn 
            420                 425                 430         


Asp Val Met Phe Pro Ser Ser Asn Glu Lys Leu Asn Ile Asn Leu Ala 
        435                 440                 445             


Met Ser Pro Leu Pro Ser Ser Glu Thr Pro Lys Pro Leu Arg Ser Ser 
    450                 455                 460                 


Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Ser Ser 
465                 470                 475                 480 


Pro Glu Ser Leu Gly Leu Ser Phe Thr Met Pro Gln Ile Gln Asp Gln 
                485                 490                 495     


Pro Ala Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu Arg 
            500                 505                 510         


Leu Leu Gln Glu Asn Val Asn Thr Pro Asn Phe Ser Gln Pro Asn Ser 
        515                 520                 525             


Pro Ser Glu Tyr Cys Phe Asp Val Asp Ser Asp Met Val Asn Val Phe 
    530                 535                 540                 


Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr Glu Ala Lys 
545                 550                 555                 560 


Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu Met Leu Ala 
                565                 570                 575     


Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser Phe Asp Gln 
            580                 585                 590         


Leu Ser Pro Leu Glu Ser Asn Ser Pro Ser Pro Pro Ser Met Ser Thr 
        595                 600                 605             


Val Thr Gly Phe Gln Gln Thr Gln Leu Gln Lys Pro Thr Ile Thr Ala 
    610                 615                 620                 


Thr Ala Thr Thr Thr Ala Thr Thr Asp Glu Ser Lys Thr Glu Thr Lys 
625                 630                 635                 640 


Asp Asn Lys Glu Asp Ile Lys Ile Leu Ile Ala Ser Pro Ser Ser Thr 
                645                 650                 655     


Gln Val Pro Gln Glu Thr Thr Thr Ala Lys Ala Ser Ala Tyr Ser Gly 
            660                 665                 670         


Thr His Ser Arg Thr Ala Ser Pro Asp Arg Ala Gly Lys Arg Val Ile 
        675                 680                 685             


Glu Gln Thr Asp Lys Ala His Pro Arg Ser Leu Asn Leu Ser Ala Thr 
    690                 695                 700                 


Leu Asn Gln Arg Asn Thr Val Pro Glu Glu Glu Leu Asn Pro Lys Thr 
705                 710                 715                 720 


Ile Ala Ser Gln Asn Ala Gln Arg Lys Arg Lys Met Glu His Asp Gly 
                725                 730                 735     


Ser Leu Phe Gln Ala Ala Gly Ile Gly Thr Leu Leu Gln Gln Pro Gly 
            740                 745                 750         


Asp Cys Ala Pro Thr Met Ser Leu Ser Trp Lys Arg Val Lys Gly Phe 
        755                 760                 765             


Ile Ser Ser Glu Gln Asn Gly Thr Glu Gln Lys Thr Ile Ile Leu Ile 
    770                 775                 780                 


Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly Gln Ser Met Asp Glu Ser 
785                 790                 795                 800 


Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys Glu Val Asn Ala Pro Ile 
                805                 810                 815     


Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu Glu Leu Leu Arg Ala Leu 
            820                 825                 830         


Asp Gln Val Asn 
        835     


<210>  7
<211>  823
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Glu Gly Ala Gly Gly Glu Asn Glu Lys Lys Asn Arg Met Ser Ser 
1               5                   10                  15      


Glu Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser 
            20                  25                  30          


Lys Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro 
        35                  40                  45              


His Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr 
    50                  55                  60                  


Ile Ser Tyr Leu Arg Val Arg Lys Leu Leu Gly Ala Gly Asp Leu Asp 
65                  70                  75                  80  


Ile Glu Asp Glu Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala 
                85                  90                  95      


Leu Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr 
            100                 105                 110         


Ile Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu 
        115                 120                 125             


Thr Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu 
    130                 135                 140                 


Met Arg Glu Met Leu Thr His Arg Asn Gly Pro Val Arg Lys Gly Lys 
145                 150                 155                 160 


Glu Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu 
                165                 170                 175     


Thr Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val 
            180                 185                 190         


Leu His Cys Thr Gly His Ile His Val Tyr Asp Thr Ser Ser Asn Gln 
        195                 200                 205             


Pro Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile 
    210                 215                 220                 


Cys Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser 
225                 230                 235                 240 


Lys Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys 
                245                 250                 255     


Asp Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu 
            260                 265                 270         


Gly Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu 
        275                 280                 285             


Thr Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly 
    290                 295                 300                 


Gln Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr 
305                 310                 315                 320 


Gln Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile 
                325                 330                 335     


Val Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile 
            340                 345                 350         


Phe Ser Leu Gln Gln Thr Glu Ser Val Leu Lys Pro Val Glu Ser Ser 
        355                 360                 365             


Asp Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr 
    370                 375                 380                 


Ser Cys Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu 
385                 390                 395                 400 


Leu Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser 
                405                 410                 415     


Asp Asp Thr Glu Thr Glu Asp Gln Gln Leu Glu Asp Val Pro Leu Tyr 
            420                 425                 430         


Asn Asp Val Met Phe Pro Ser Ser Asn Glu Lys Leu Asn Ile Asn Leu 
        435                 440                 445             


Ala Met Ser Pro Leu Pro Ala Ser Glu Thr Pro Lys Pro Leu Arg Ser 
    450                 455                 460                 


Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Ser 
465                 470                 475                 480 


Ser Pro Glu Ser Leu Gly Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                485                 490                 495     


Gln Pro Ala Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
            500                 505                 510         


Pro Asn Ser Pro Ser Glu Tyr Cys Phe Asp Val Asp Ser Asp Met Val 
        515                 520                 525             


Asn Val Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
    530                 535                 540                 


Glu Ala Lys Asn Pro Phe Ser Ala Gln Asp Thr Asp Leu Asp Leu Glu 
545                 550                 555                 560 


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                565                 570                 575     


Phe Asp Gln Leu Ser Pro Leu Glu Ser Asn Ser Pro Ser Pro Pro Ser 
            580                 585                 590         


Val Ser Thr Val Thr Gly Phe Gln Gln Thr Gln Leu Gln Lys Pro Thr 
        595                 600                 605             


Ile Thr Val Thr Ala Thr Ala Thr Ala Thr Thr Asp Glu Ser Lys Ala 
    610                 615                 620                 


Val Thr Lys Asp Asn Ile Glu Asp Ile Lys Ile Leu Ile Ala Ser Pro 
625                 630                 635                 640 


Pro Ser Thr Gln Val Pro Gln Glu Met Thr Thr Ala Lys Ala Ser Ala 
                645                 650                 655     


Tyr Ser Gly Thr His Ser Arg Thr Ala Ser Pro Asp Arg Ala Gly Lys 
            660                 665                 670         


Arg Val Ile Glu Lys Thr Asp Lys Ala His Pro Arg Ser Leu Asn Leu 
        675                 680                 685             


Ser Val Thr Leu Asn Gln Arg Asn Thr Val Pro Glu Glu Glu Leu Asn 
    690                 695                 700                 


Pro Lys Thr Ile Ala Leu Gln Asn Ala Gln Arg Lys Arg Lys Met Glu 
705                 710                 715                 720 


His Asp Gly Ser Leu Phe Gln Ala Ala Gly Ile Gly Thr Leu Leu Gln 
                725                 730                 735     


Gln Pro Gly Asp Arg Ala Pro Thr Met Ser Leu Ser Trp Lys Arg Val 
            740                 745                 750         


Lys Gly Tyr Ile Ser Ser Glu Gln Asp Gly Met Glu Gln Lys Thr Ile 
        755                 760                 765             


Phe Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly Gln Ser Met 
    770                 775                 780                 


Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys Glu Val Asn 
785                 790                 795                 800 


Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu Glu Leu Leu 
                805                 810                 815     


Arg Ala Leu Asp Gln Val Asn 
            820             


<210>  8
<211>  811
<212>  PRT
<213>  Gallus gallus

<400>  8

Met Asp Ser Pro Gly Gly Val Thr Asp Lys Lys Arg Ile Ser Ser Glu 
1               5                   10                  15      


Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Cys Arg Arg Ser Lys 
            20                  25                  30          


Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
        35                  40                  45              


Thr Val Ser Ala His Leu Asp Lys Ala Ser Ile Met Arg Leu Thr Ile 
    50                  55                  60                  


Ser Tyr Leu Arg Met Arg Lys Leu Leu Asp Ala Gly Glu Leu Glu Thr 
65                  70                  75                  80  


Glu Ala Asn Met Glu Lys Glu Leu Asn Cys Phe Tyr Leu Lys Ala Leu 
                85                  90                  95      


Asp Gly Phe Val Met Val Leu Ser Glu Asp Gly Asp Met Ile Tyr Met 
            100                 105                 110         


Ser Glu Asn Val Asn Lys Cys Met Gly Leu Thr Gln Phe Asp Leu Thr 
        115                 120                 125             


Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Leu 
    130                 135                 140                 


Arg Glu Met Leu Thr His Arg Asn Gly Pro Val Lys Lys Gly Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Glu Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Val Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Thr Gly His Ile Arg Val Tyr Asp Thr Cys Asn Asn Gln Thr 
        195                 200                 205             


His Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Val Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
            260                 265                 270         


Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Gln Gly Gly Tyr Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Leu Ser Gly Ile Val Gln Lys Asp Leu Ile Phe 
            340                 345                 350         


Ser Leu Gly Gln Thr Glu Cys Met Leu Lys Pro Val Glu Ser Pro Glu 
        355                 360                 365             


Met Lys Met Thr Lys Ile Phe Ser Lys Asp Asp Trp Asp Asp Thr Asn 
    370                 375                 380                 


Ser Leu Phe Glu Lys Leu Lys Gln Glu Pro Asp Ala Leu Thr Val Leu 
385                 390                 395                 400 


Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Ser Ser Asn 
                405                 410                 415     


Glu Ser Asp Glu Gln Gln Cys Asp Glu Val Pro Leu Tyr Asn Asp Val 
            420                 425                 430         


Met Leu Pro Ser Ser Ser Glu Lys Leu Gln Asn Ile Asn Ile Ala Met 
        435                 440                 445             


Ser Pro Leu Pro Ala Ser Glu Thr Thr Lys Pro Leu Arg Ser Asn Ala 
    450                 455                 460                 


Asp Pro Ala Leu Asn Arg Glu Val Val Ser Lys Leu Glu Pro Asn Thr 
465                 470                 475                 480 


Glu Thr Leu Glu Leu Ser Phe Thr Met Pro Gln Val Gln Glu Gln Pro 
                485                 490                 495     


Thr Ser Pro Ser Asp Ala Ser Thr Ser Gln Ser Ser Pro Glu Pro Ser 
            500                 505                 510         


Ser Pro Asn Asp Tyr Cys Phe Asp Val Asp Asn Asp Met Ala Asn Glu 
        515                 520                 525             


Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Ile Asp Thr Glu Ala 
    530                 535                 540                 


Lys Asn Pro Phe Ser Thr Gln Glu Thr Asp Leu Asp Leu Glu Met Leu 
545                 550                 555                 560 


Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser Phe Asp 
                565                 570                 575     


Gln Leu Ser Pro Leu Glu Ser Ser Ser Ser Gly Ser Gln Asn Ala Ala 
            580                 585                 590         


Thr Ile Thr Ile Leu Gln Gln Thr Gln Thr Pro Ser Thr Ala Ala Asp 
        595                 600                 605             


Glu Ile Lys Pro Val Ala Glu Arg Val Asp Asp Val Lys Ala Leu Ile 
    610                 615                 620                 


Val Pro Ser Ser Pro Val His Val Ile Asn Asp Thr Ser Ser Ala Pro 
625                 630                 635                 640 


Ala Ser Pro Tyr Ser Gly Asn Arg Ser Arg Thr Ala Ser Pro Ile Arg 
                645                 650                 655     


Ala Gly Lys Gly Thr Leu Glu Gln Thr Glu Lys Ser Cys Pro Gly Ala 
            660                 665                 670         


Pro Ser Leu Ile Thr Val Thr Leu Asn Lys Arg Ser Thr Ala Met Asp 
        675                 680                 685             


Glu Glu Leu Asn Pro Lys Met Leu Ala Leu His Asn Ala Gln Arg Lys 
    690                 695                 700                 


Arg Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly 
705                 710                 715                 720 


Ser Leu Phe Gln Gln Thr Gly Asp Arg Gly Gly Asn Ala Ser Leu Ala 
                725                 730                 735     


Trp Lys Arg Val Lys Ala Cys Lys Thr Asn Gly His Asn Gly Val Glu 
            740                 745                 750         


Gln Lys Thr Ile Ile Leu Leu Ser Thr Asp Ile Ala Ser Lys Leu Leu 
        755                 760                 765             


Gly Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp 
    770                 775                 780                 


Cys Glu Val Asn Ala Pro Ile Gln Gly Asn Arg Asn Leu Leu Gln Gly 
785                 790                 795                 800 


Glu Glu Leu Leu Arg Ala Leu Asp Gln Val Asn 
                805                 810     


<210>  9
<211>  533
<212>  PRT
<213>  Danio rerio

<400>  9

Met Asp Thr Gly Val Val Thr Glu Lys Lys Arg Val Ser Ser Glu Arg 
1               5                   10                  15      


Arg Lys Gly Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Gly Lys Glu 
            20                  25                  30          


Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His Asn 
        35                  40                  45              


Val Thr Ser His Leu Asp Lys Ala Ser Ile Met Arg Leu Thr Ile Ser 
    50                  55                  60                  


Tyr Leu Arg Met Arg Lys Leu Leu Asn Ser Asp Glu Lys Glu Glu Lys 
65                  70                  75                  80  


Glu Glu Asn Glu Leu Glu Ser Gln Leu Asn Gly Phe Tyr Leu Lys Ala 
                85                  90                  95      


Leu Glu Gly Phe Leu Met Val Leu Ser Glu Asp Gly Asp Met Val Tyr 
            100                 105                 110         


Leu Ser Glu Asn Val Ser Lys Ser Met Gly Leu Thr Gln Phe Asp Leu 
        115                 120                 125             


Thr Gly His Ser Ile Phe Glu Phe Ser His Pro Cys Asp His Glu Glu 
    130                 135                 140                 


Leu Arg Glu Met Leu Val His Arg Thr Gly Ser Lys Lys Thr Lys Glu 
145                 150                 155                 160 


Gln Asn Thr Glu Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                165                 170                 175     


Ser Arg Gly Arg Thr Val Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
            180                 185                 190         


His Cys Ala Gly His Val Arg Val His Glu Gly Ser Glu Ala Ser Glu 
        195                 200                 205             


Asp Ser Gly Phe Lys Glu Pro Pro Val Thr Tyr Leu Val Leu Ile Cys 
    210                 215                 220                 


Glu Pro Ile Pro His Pro Ser Asn Ile Glu Val Pro Leu Asp Ser Lys 
225                 230                 235                 240 


Thr Phe Leu Ser Arg His Thr Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                245                 250                 255     


Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Asp Asp Leu Leu Asn 
            260                 265                 270         


Arg Ser Val Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
        275                 280                 285             


Lys Thr His His Asn Leu Phe Ala Lys Gly Gln Ala Thr Thr Gly Gln 
    290                 295                 300                 


Tyr Arg Met Leu Ala Lys Lys Gly Gly Phe Val Trp Val Glu Thr Gln 
305                 310                 315                 320 


Ala Thr Val Ile Tyr Asn Pro Lys Asn Ser Gln Pro Gln Cys Ile Val 
                325                 330                 335     


Cys Val Asn Tyr Val Leu Ser Gly Ile Val Glu Gly Asp Val Val Leu 
            340                 345                 350         


Ser Leu Gln Gln Thr Val Thr Glu Pro Lys Ala Val Glu Lys Glu Ser 
        355                 360                 365             


Glu Glu Thr Glu Glu Lys Thr Ser Glu Leu Asp Ile Leu Lys Leu Phe 
    370                 375                 380                 


Lys Pro Glu Ser Leu Asn Cys Ser Leu Glu Ser Ser Thr Leu Tyr Asn 
385                 390                 395                 400 


Lys Leu Lys Glu Glu Pro Glu Ala Leu Thr Val Leu Ala Pro Ala Ala 
                405                 410                 415     


Gly Asp Ala Ile Ile Ser Leu Asp Phe Asn Asn Ser Asp Ser Asp Ile 
            420                 425                 430         


Gln Leu Leu Lys Glu Val Pro Leu Tyr Asn Asp Val Met Leu Pro Ser 
        435                 440                 445             


Ser Ser Glu Lys Leu Pro Leu Ser Leu Ser Pro Leu Thr Pro Ser Asp 
    450                 455                 460                 


Ser Leu Ser Ser His Ala Thr Thr Ala Lys Ser Thr Leu Pro Cys Arg 
465                 470                 475                 480 


Arg Arg His Pro Gly Pro Leu His Pro Tyr Thr Cys Cys Arg Arg Cys 
                485                 490                 495     


Ala Val His Leu Ser Arg Ser Ser Val Ala Val Gly Met Pro His Leu 
            500                 505                 510         


Phe Asp Pro Ala Pro His Arg Ala Ala Val Ser Ser Thr Thr Glu Lys 
        515                 520                 525             


Cys Leu Gln Arg Cys 
    530             


<210>  10
<211>  721
<212>  PRT
<213>  Caenorhabditis elegans

<400>  10

Met Glu Asp Asn Arg Lys Arg Asn Met Glu Arg Arg Arg Glu Thr Ser 
1               5                   10                  15      


Arg His Ala Ala Arg Asp Arg Arg Ser Lys Glu Ser Asp Ile Phe Asp 
            20                  25                  30          


Asp Leu Lys Met Cys Val Pro Ile Val Glu Glu Gly Thr Val Thr His 
        35                  40                  45              


Leu Asp Arg Ile Ala Leu Leu Arg Val Ala Ala Thr Ile Cys Arg Leu 
    50                  55                  60                  


Arg Lys Thr Ala Gly Asn Val Leu Glu Asn Asn Leu Asp Asn Glu Ile 
65                  70                  75                  80  


Thr Asn Glu Val Trp Thr Glu Asp Thr Ile Ala Glu Cys Leu Asp Gly 
                85                  90                  95      


Phe Val Met Ile Val Asp Ser Asp Ser Ser Ile Leu Tyr Val Thr Glu 
            100                 105                 110         


Ser Val Ala Met Tyr Leu Gly Leu Thr Gln Thr Asp Leu Thr Gly Arg 
        115                 120                 125             


Ala Leu Arg Asp Phe Leu His Pro Ser Asp Tyr Asp Glu Phe Asp Lys 
    130                 135                 140                 


Gln Ser Lys Met Leu His Lys Pro Arg Gly Glu Asp Thr Asp Thr Thr 
145                 150                 155                 160 


Gly Ile Asn Met Val Leu Arg Met Lys Thr Val Ile Ser Pro Arg Gly 
                165                 170                 175     


Arg Cys Leu Asn Leu Lys Ser Ala Leu Tyr Lys Ser Val Ser Phe Leu 
            180                 185                 190         


Val His Ser Lys Val Ser Thr Gly Gly His Val Ser Phe Met Gln Gly 
        195                 200                 205             


Ile Thr Ile Pro Ala Gly Gln Gly Thr Thr Asn Ala Asn Ala Ser Ala 
    210                 215                 220                 


Met Thr Lys Tyr Thr Glu Ser Pro Met Gly Ala Phe Thr Thr Arg His 
225                 230                 235                 240 


Thr Cys Asp Met Arg Ile Thr Phe Val Ser Asp Lys Phe Asn Tyr Ile 
                245                 250                 255     


Leu Lys Ser Glu Leu Lys Thr Leu Met Gly Thr Ser Phe Tyr Glu Leu 
            260                 265                 270         


Val His Pro Ala Asp Met Met Ile Val Ser Lys Ser Met Lys Glu Leu 
        275                 280                 285             


Phe Ala Lys Gly His Ile Arg Thr Pro Tyr Tyr Arg Leu Ile Ala Ala 
    290                 295                 300                 


Asn Asp Thr Leu Ala Trp Ile Gln Thr Glu Ala Thr Thr Ile Thr His 
305                 310                 315                 320 


Thr Thr Lys Gly Gln Lys Gly Gln Tyr Val Ile Cys Val His Tyr Val 
                325                 330                 335     


Leu Gly Ile Gln Gly Ala Glu Glu Ser Leu Val Val Cys Thr Asp Ser 
            340                 345                 350         


Met Pro Ala Gly Met Gln Val Asp Ile Lys Lys Glu Val Asp Asp Thr 
        355                 360                 365             


Arg Asp Tyr Ile Gly Arg Gln Pro Glu Ile Val Glu Cys Val Asp Phe 
    370                 375                 380                 


Thr Pro Leu Ile Glu Pro Glu Asp Pro Phe Asp Thr Val Ile Glu Pro 
385                 390                 395                 400 


Val Val Gly Gly Glu Glu Pro Val Lys Gln Ala Asp Met Gly Ala Arg 
                405                 410                 415     


Lys Asn Ser Tyr Asp Asp Val Leu Gln Trp Leu Phe Arg Asp Gln Pro 
            420                 425                 430         


Ser Ser Pro Pro Pro Ala Arg Tyr Arg Ser Ala Asp Arg Phe Arg Thr 
        435                 440                 445             


Thr Glu Pro Ser Asn Phe Gly Ser Ala Leu Ala Ser Pro Asp Phe Met 
    450                 455                 460                 


Asp Ser Ser Ser Arg Thr Ser Arg Pro Lys Thr Ser Tyr Gly Arg Arg 
465                 470                 475                 480 


Ala Gln Ser Gln Gly Ser Arg Thr Thr Gly Ser Ser Ser Thr Ser Ala 
                485                 490                 495     


Ser Ala Thr Leu Pro His Ser Ala Asn Tyr Ser Pro Leu Ala Glu Gly 
            500                 505                 510         


Ile Ser Gln Cys Gly Leu Asn Ser Pro Pro Ser Cys Ser Ile Lys Ser 
        515                 520                 525             


Gly Gln Val Val Tyr Gly Asp Ala Arg Ser Met Gly Arg Ser Cys Asp 
    530                 535                 540                 


Pro Ser Asp Ser Ser Arg Arg Phe Ser Ala Leu Ser Pro Ser Asp Thr 
545                 550                 555                 560 


Leu Asn Val Ser Ser Thr Arg Gly Ile Asn Pro Val Ile Gly Ser Asn 
                565                 570                 575     


Asp Val Phe Ser Thr Met Pro Phe Ala Asp Ser Ile Ala Ile Ala Glu 
            580                 585                 590         


Arg Ile Asp Ser Ser Pro Thr Leu Thr Ser Gly Glu Pro Ile Leu Cys 
        595                 600                 605             


Asp Asp Leu Gln Trp Glu Glu Pro Asp Leu Ser Cys Leu Ala Pro Phe 
    610                 615                 620                 


Val Asp Thr Tyr Asp Met Met Gln Met Asp Glu Gly Leu Pro Pro Glu 
625                 630                 635                 640 


Leu Gln Ala Leu Tyr Asp Leu Pro Asp Phe Thr Pro Ala Val Pro Gln 
                645                 650                 655     


Ala Pro Ala Ala Arg Pro Val His Ile Asp Arg Ser Pro Pro Ala Lys 
            660                 665                 670         


Arg Met His Gln Ser Gly Pro Ser Asp Leu Asp Phe Met Tyr Thr Gln 
        675                 680                 685             


His Tyr Gln Pro Phe Gln Gln Asp Glu Thr Tyr Trp Gln Gly Gln Gln 
    690                 695                 700                 


Gln Gln Asn Glu Gln Gln Pro Ser Ser Tyr Ser Pro Phe Pro Met Leu 
705                 710                 715                 720 


Ser 
    


<210>  11
<211>  163
<212>  PRT
<213>  Homo  sapiens

<400>  11

Phe Phe Leu Arg Met Lys Cys Thr Leu Thr Ser Arg Gly Arg Thr Met 
1               5                   10                  15      


Asn Ile Lys Ser Ala Thr Trp Lys Val Leu His Cys Thr Gly His Ile 
            20                  25                  30          


His Val Tyr Asp Thr Asn Ser Asn Gln Pro Gln Cys Gly Tyr Lys Lys 
        35                  40                  45              


Pro Pro Met Thr Cys Leu Val Leu Ile Cys Glu Pro Ile Pro His Pro 
    50                  55                  60                  


Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys Thr Phe Leu Ser Arg His 
65                  70                  75                  80  


Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp Glu Arg Ile Thr Glu Leu 
                85                  90                  95      


Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly Arg Ser Ile Tyr Glu Tyr 
            100                 105                 110         


Tyr His Ala Leu Asp Ser Asp His Leu Thr Lys Thr His His Asp Met 
        115                 120                 125             


Phe Thr Lys Gly Gln Val Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys 
    130                 135                 140                 


Arg Gly Gly Tyr Val Trp Val Glu Thr Gln Ala Thr Val Ile Tyr Asn 
145                 150                 155                 160 


Thr Lys Asn 
            


<210>  12
<211>  163
<212>  PRT
<213>  Pan troglodytes

<400>  12

Phe Phe Leu Arg Met Lys Cys Thr Leu Thr Ser Arg Gly Arg Thr Met 
1               5                   10                  15      


Asn Ile Lys Ser Ala Thr Trp Lys Val Leu His Cys Thr Gly His Ile 
            20                  25                  30          


His Val Tyr Asp Thr Asn Ser Asn Gln Pro Gln Cys Gly Tyr Lys Lys 
        35                  40                  45              


Pro Pro Met Thr Cys Leu Val Leu Ile Cys Glu Pro Ile Pro His Pro 
    50                  55                  60                  


Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys Thr Phe Leu Ser Arg His 
65                  70                  75                  80  


Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp Glu Arg Ile Thr Glu Leu 
                85                  90                  95      


Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly Arg Ser Ile Tyr Glu Tyr 
            100                 105                 110         


Tyr His Ala Leu Asp Ser Asp His Leu Thr Lys Thr His His Asp Met 
        115                 120                 125             


Phe Thr Lys Gly Gln Val Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys 
    130                 135                 140                 


Arg Gly Gly Tyr Val Trp Val Glu Thr Gln Ala Thr Val Ile Tyr Asn 
145                 150                 155                 160 


Thr Lys Asn 
            


<210>  13
<211>  163
<212>  PRT
<213>  Macaca mulatta

<400>  13

Phe Phe Leu Arg Met Lys Cys Thr Leu Thr Ser Arg Gly Arg Thr Met 
1               5                   10                  15      


Asn Ile Lys Ser Ala Thr Trp Lys Val Leu His Cys Thr Gly His Ile 
            20                  25                  30          


His Val Tyr Asp Thr Asn Ser Asn Gln Pro Gln Cys Gly Tyr Lys Lys 
        35                  40                  45              


Pro Pro Met Thr Cys Leu Val Leu Ile Cys Glu Pro Ile Pro His Pro 
    50                  55                  60                  


Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys Thr Phe Leu Ser Arg His 
65                  70                  75                  80  


Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp Glu Arg Ile Thr Glu Leu 
                85                  90                  95      


Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly Arg Ser Ile Tyr Glu Tyr 
            100                 105                 110         


Tyr His Ala Leu Asp Ser Asp His Leu Thr Lys Thr His His Asp Met 
        115                 120                 125             


Phe Thr Lys Gly Gln Val Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys 
    130                 135                 140                 


Arg Gly Gly Tyr Val Trp Val Glu Thr Gln Ala Thr Val Ile Tyr Asn 
145                 150                 155                 160 


Thr Lys Asn 
            


<210>  14
<211>  163
<212>  PRT
<213>  Canis lupus familiaris

<400>  14

Phe Phe Leu Arg Met Lys Cys Thr Leu Thr Ser Arg Gly Arg Thr Met 
1               5                   10                  15      


Asn Ile Lys Ser Ala Thr Trp Lys Val Leu His Cys Thr Gly His Ile 
            20                  25                  30          


His Val Tyr Asp Thr Asn Ser Asn Gln Ser Gln Cys Gly Tyr Lys Lys 
        35                  40                  45              


Pro Pro Met Thr Cys Leu Val Leu Ile Cys Glu Pro Ile Pro His Pro 
    50                  55                  60                  


Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys Thr Phe Leu Ser Arg His 
65                  70                  75                  80  


Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp Glu Arg Ile Thr Glu Leu 
                85                  90                  95      


Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly Arg Ser Ile Tyr Glu Tyr 
            100                 105                 110         


Tyr His Ala Leu Asp Ser Asp His Leu Thr Lys Thr His His Asp Met 
        115                 120                 125             


Phe Thr Lys Gly Gln Val Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys 
    130                 135                 140                 


Arg Gly Gly Tyr Val Trp Val Glu Thr Gln Ala Thr Val Ile Tyr Asn 
145                 150                 155                 160 


Thr Lys Asn 
            


<210>  15
<211>  163
<212>  PRT
<213>  Bos Taurus

<400>  15

Phe Phe Leu Arg Met Lys Cys Thr Leu Thr Ser Arg Gly Arg Thr Met 
1               5                   10                  15      


Asn Ile Lys Ser Ala Thr Trp Lys Val Leu His Cys Thr Gly His Ile 
            20                  25                  30          


His Val Tyr Asp Thr Asn Ser Asn Gln Ser Gln Cys Gly Tyr Lys Lys 
        35                  40                  45              


Pro Pro Met Thr Cys Leu Val Leu Ile Cys Glu Pro Ile Pro His Pro 
    50                  55                  60                  


Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys Thr Phe Leu Ser Arg His 
65                  70                  75                  80  


Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp Glu Arg Ile Thr Glu Leu 
                85                  90                  95      


Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly Arg Ser Ile Tyr Glu Tyr 
            100                 105                 110         


Tyr His Ala Leu Asp Ser Asp His Leu Thr Lys Thr His His Asp Met 
        115                 120                 125             


Phe Thr Lys Gly Gln Val Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys 
    130                 135                 140                 


Arg Gly Gly Tyr Val Trp Ile Glu Thr Gln Ala Thr Val Ile Tyr Asn 
145                 150                 155                 160 


Thr Lys Asn 
            


<210>  16
<211>  163
<212>  PRT
<213>  Mus musculus

<400>  16

Phe Phe Leu Arg Met Lys Cys Thr Leu Thr Ser Arg Gly Arg Thr Met 
1               5                   10                  15      


Asn Ile Lys Ser Ala Thr Trp Lys Val Leu His Cys Thr Gly His Ile 
            20                  25                  30          


His Val Tyr Asp Thr Asn Ser Asn Gln Pro Gln Cys Gly Tyr Lys Lys 
        35                  40                  45              


Pro Pro Met Thr Cys Leu Val Leu Ile Cys Glu Pro Ile Pro His Pro 
    50                  55                  60                  


Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys Thr Phe Leu Ser Arg His 
65                  70                  75                  80  


Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp Glu Arg Ile Thr Glu Leu 
                85                  90                  95      


Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly Arg Ser Ile Tyr Glu Tyr 
            100                 105                 110         


Tyr His Ala Leu Asp Ser Asp His Leu Thr Lys Thr His His Asp Met 
        115                 120                 125             


Phe Thr Lys Gly Gln Val Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys 
    130                 135                 140                 


Arg Gly Gly Tyr Val Trp Val Glu Thr Gln Ala Thr Val Ile Tyr Asn 
145                 150                 155                 160 


Thr Lys Asn 
            


<210>  17
<211>  163
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Phe Phe Leu Arg Met Lys Cys Thr Leu Thr Ser Arg Gly Arg Thr Met 
1               5                   10                  15      


Asn Ile Lys Ser Ala Thr Trp Lys Val Leu His Cys Thr Gly His Ile 
            20                  25                  30          


His Val Tyr Asp Thr Ser Ser Asn Gln Pro Gln Cys Gly Tyr Lys Lys 
        35                  40                  45              


Pro Pro Met Thr Cys Leu Val Leu Ile Cys Glu Pro Ile Pro His Pro 
    50                  55                  60                  


Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys Thr Phe Leu Ser Arg His 
65                  70                  75                  80  


Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp Glu Arg Ile Thr Glu Leu 
                85                  90                  95      


Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly Arg Ser Ile Tyr Glu Tyr 
            100                 105                 110         


Tyr His Ala Leu Asp Ser Asp His Leu Thr Lys Thr His His Asp Met 
        115                 120                 125             


Phe Thr Lys Gly Gln Val Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys 
    130                 135                 140                 


Arg Gly Gly Tyr Val Trp Val Glu Thr Gln Ala Thr Val Ile Tyr Asn 
145                 150                 155                 160 


Thr Lys Asn 
            


<210>  18
<211>  163
<212>  PRT
<213>  Gallus gallus

<400>  18

Phe Phe Leu Arg Met Lys Cys Thr Leu Thr Ser Arg Gly Arg Thr Val 
1               5                   10                  15      


Asn Ile Lys Ser Ala Thr Trp Lys Val Leu His Cys Thr Gly His Ile 
            20                  25                  30          


Arg Val Tyr Asp Thr Cys Asn Asn Gln Thr His Cys Gly Tyr Lys Lys 
        35                  40                  45              


Pro Pro Met Thr Cys Leu Val Leu Ile Cys Glu Pro Ile Pro His Pro 
    50                  55                  60                  


Ser Asn Ile Glu Val Pro Leu Asp Ser Lys Thr Phe Leu Ser Arg His 
65                  70                  75                  80  


Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp Glu Arg Ile Thr Glu Leu 
                85                  90                  95      


Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly Arg Ser Ile Tyr Glu Tyr 
            100                 105                 110         


Tyr His Ala Leu Asp Ser Asp His Leu Thr Lys Thr His His Asp Met 
        115                 120                 125             


Phe Thr Lys Gly Gln Val Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys 
    130                 135                 140                 


Gln Gly Gly Tyr Val Trp Val Glu Thr Gln Ala Thr Val Ile Tyr Asn 
145                 150                 155                 160 


Thr Lys Asn 
            


<210>  19
<211>  166
<212>  PRT
<213>  Danio rerio

<400>  19

Phe Phe Leu Arg Met Lys Cys Thr Leu Thr Ser Arg Gly Arg Thr Val 
1               5                   10                  15      


Asn Ile Lys Ser Ala Thr Trp Lys Val Leu His Cys Ala Gly His Val 
            20                  25                  30          


Arg Val His Glu Gly Ser Glu Ala Ser Glu Asp Ser Gly Phe Lys Glu 
        35                  40                  45              


Pro Pro Val Thr Tyr Leu Val Leu Ile Cys Glu Pro Ile Pro His Pro 
    50                  55                  60                  


Ser Asn Ile Glu Val Pro Leu Asp Ser Lys Thr Phe Leu Ser Arg His 
65                  70                  75                  80  


Thr Leu Asp Met Lys Phe Ser Tyr Cys Asp Glu Arg Ile Thr Glu Leu 
                85                  90                  95      


Met Gly Tyr Glu Pro Asp Asp Leu Leu Asn Arg Ser Val Tyr Glu Tyr 
            100                 105                 110         


Tyr His Ala Leu Asp Ser Asp His Leu Thr Lys Thr His His Asn Leu 
        115                 120                 125             


Phe Ala Lys Gly Gln Ala Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys 
    130                 135                 140                 


Lys Gly Gly Phe Val Trp Val Glu Thr Gln Ala Thr Val Ile Tyr Asn 
145                 150                 155                 160 


Pro Lys Asn Ser Gln Pro 
                165     


<210>  20
<211>  161
<212>  PRT
<213>  Caenorhabditis elegans

<400>  20

Met Val Leu Arg Met Lys Thr Val Ile Ser Pro Arg Gly Arg Cys Leu 
1               5                   10                  15      


Asn Leu Lys Ser Ala Leu Tyr Lys Ser Val Ser Phe Leu Val His Ser 
            20                  25                  30          


Lys Val Ser Thr Gly Gly His Val Ser Phe Met Gln Gly Ile Thr Ile 
        35                  40                  45              


Pro Ala Gly Gln Gly Thr Thr Asn Ala Asn Ala Ser Ala Met Thr Lys 
    50                  55                  60                  


Tyr Thr Glu Ser Pro Met Gly Ala Phe Thr Thr Arg His Thr Cys Asp 
65                  70                  75                  80  


Met Arg Ile Thr Phe Val Ser Asp Lys Phe Asn Tyr Ile Leu Lys Ser 
                85                  90                  95      


Glu Leu Lys Thr Leu Met Gly Thr Ser Phe Tyr Glu Leu Val His Pro 
            100                 105                 110         


Ala Asp Met Met Ile Val Ser Lys Ser Met Lys Glu Leu Phe Ala Lys 
        115                 120                 125             


Gly His Ile Arg Thr Pro Tyr Tyr Arg Leu Ile Ala Ala Asn Asp Thr 
    130                 135                 140                 


Leu Ala Trp Ile Gln Thr Glu Ala Thr Thr Ile Thr His Thr Thr Lys 
145                 150                 155                 160 


Gly 
    


<210>  21
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys 
    450             


<210>  22
<211>  453
<212>  PRT
<213>  Pan troglodytes

<400>  22

Met Asp Phe Phe Arg Ile Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Pro 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Asp Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys 
    450             


<210>  23
<211>  438
<212>  PRT
<213>  Macaca mulatta

<400>  23

Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe 
65                  70                  75                  80  


Ser Pro Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
145                 150                 155                 160 


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Ala Ser Pro Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Thr Glu Ser Ser Pro Gln Ala Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Glu Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Asp Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu 
                405                 410                 415     


Lys Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Cys 
        435             


<210>  24
<211>  452
<212>  PRT
<213>  Canis lupus familiaris

<400>  24

Met Asp Leu Leu Arg Arg Val Glu Thr Pro Ala Ala Ala Met Pro Leu 
1               5                   10                  15      


Asn Val Ser Phe Ala Asn Arg Asn Tyr Asp Leu Asp Tyr Asp Ser Val 
            20                  25                  30          


Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln Gln Gln 
        35                  40                  45              


Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile Trp Lys 
    50                  55                  60                  


Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg Ser 
65                  70                  75                  80  


Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Ala Ser Phe Ser Pro Arg 
                85                  90                  95      


Gly Asp Asp Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp Gln Leu 
            100                 105                 110         


Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln Ser Phe 
        115                 120                 125             


Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile Ile Gln 
    130                 135                 140                 


Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val Ser Glu 
145                 150                 155                 160 


Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser Pro Ser 
                165                 170                 175     


Pro Ala Arg Gly Pro Gly Gly Cys Ser Thr Ser Ser Leu Tyr Leu Gln 
            180                 185                 190         


Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val Val Phe 
        195                 200                 205             


Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Pro Cys Ala Ser Pro 
    210                 215                 220                 


Asp Ser Ala Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser Ser Ala 
225                 230                 235                 240 


Glu Ser Ser Pro Arg Ala Ser Pro Glu Pro Leu Ala Leu His Glu Glu 
                245                 250                 255     


Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu Asp Glu 
            260                 265                 270         


Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Pro Pro Ala Lys 
        275                 280                 285             


Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys Pro Pro 
    290                 295                 300                 


His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His Gln His 
305                 310                 315                 320 


Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala Ala Lys 
                325                 330                 335     


Arg Ala Arg Leu Asp Ser Gly Arg Val Leu Lys Gln Ile Ser Asn Asn 
            340                 345                 350         


Arg Lys Cys Ala Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn Asp Lys 
        355                 360                 365             


Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu Lys 
    370                 375                 380                 


Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu Asn Asn 
385                 390                 395                 400 


Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr Ile 
                405                 410                 415     


Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Leu Ser Glu Lys Asp Leu 
            420                 425                 430         


Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln Leu Arg 
        435                 440                 445             


Asn Ser Gly Ala 
    450         


<210>  25
<211>  439
<212>  PRT
<213>  Bos taurus

<400>  25

Met Pro Leu Asn Val Ser Phe Ala Asn Lys Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


His Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Ala Ser Phe 
65                  70                  75                  80  


Ser Pro Arg Gly Asp Asp Asp Gly Gly Gly Gly Ser Phe Ser Ser Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Leu Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Gly Gly 
145                 150                 155                 160 


Ser Pro Ser Pro Ala Arg Gly His Gly Gly Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Pro Cys 
        195                 200                 205             


Ala Ser Pro Asp Ser Thr Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Ala Glu Ser Ser Pro Arg Ala Ser Pro Glu Pro Leu Ala Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Pro 
            260                 265                 270         


Pro Ala Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Ser His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Ala Lys Leu Asp Ser Gly Arg Val Leu Lys Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Ala Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Asp Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Val Gln Ala Glu Gln Gln Lys Leu Lys Ser Glu 
                405                 410                 415     


Ile Asp Val Leu Gln Lys Arg Arg Glu Gln Leu Lys Leu Lys Leu Glu 
            420                 425                 430         


Gln Ile Arg Asn Ser Cys Ala 
        435                 


<210>  26
<211>  454
<212>  PRT
<213>  Mus musculus

<400>  26

Met Asp Phe Leu Trp Ala Leu Glu Thr Pro Gln Thr Ala Thr Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Asn Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Ile Cys Asp Glu Glu Glu Asn Phe Tyr His 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Ala Thr Ser Phe 
                85                  90                  95      


Ser Pro Arg Glu Asp Asp Asp Gly Gly Gly Gly Asn Phe Ser Thr Ala 
            100                 105                 110         


Asp Gln Leu Glu Met Met Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
        115                 120                 125             


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
    130                 135                 140                 


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
145                 150                 155                 160 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Thr 
                165                 170                 175     


Ser Leu Ser Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
            180                 185                 190         


Tyr Leu Gln Asp Leu Thr Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
        195                 200                 205             


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
    210                 215                 220                 


Thr Ser Ser Asp Ser Thr Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
225                 230                 235                 240 


Ser Ser Glu Ser Ser Pro Arg Ala Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Thr Pro 
        275                 280                 285             


Ala Lys Arg Ser Glu Ser Gly Ser Ser Pro Ser Arg Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Ala Lys Leu Asp Ser Gly Arg Val Leu Lys Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Ser Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Asp Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Ile Gln Ala Asp Glu His Lys Leu Thr Ser Glu Lys 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Gly Ala 
    450                 


<210>  27
<211>  453
<212>  PRT
<213>  Rattus norvegicus

<400>  27

Met Asn Phe Leu Trp Glu Val Glu Asn Pro Thr Val Thr Thr Met Pro 
1               5                   10                  15      


Leu Asn Val Ser Phe Ala Asn Arg Asn Tyr Asp Leu Asp Tyr Asp Ser 
            20                  25                  30          


Val Gln Pro Tyr Phe Ile Cys Asp Glu Glu Glu Asn Phe Tyr His Gln 
        35                  40                  45              


Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile Trp 
    50                  55                  60                  


Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg 
65                  70                  75                  80  


Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Ala Thr Ser Phe Ser 
                85                  90                  95      


Pro Arg Glu Asp Asp Asp Gly Gly Gly Gly Asn Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Met Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Thr Ser 
                165                 170                 175     


Leu Ser Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Thr Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Thr 
    210                 215                 220                 


Ser Ser Asp Ser Thr Ala Phe Ser Ser Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Glu Ser Ser Pro Arg Ala Thr Pro Glu Pro Leu Val Leu His Glu 
                245                 250                 255     


Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Asp Asp 
            260                 265                 270         


Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Pro Pro Ala 
        275                 280                 285             


Lys Arg Ser Glu Ser Gly Ser Ser Pro Ser Arg Gly His Ser Lys Pro 
    290                 295                 300                 


Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His Gln 
305                 310                 315                 320 


His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala Ala 
                325                 330                 335     


Lys Arg Ala Lys Leu Asp Ser Gly Arg Val Leu Lys Gln Ile Ser Asn 
            340                 345                 350         


Asn Arg Lys Cys Ser Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn Asp 
        355                 360                 365             


Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu 
    370                 375                 380                 


Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu Asn 
385                 390                 395                 400 


Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr 
                405                 410                 415     


Ile Leu Ser Val Gln Ala Asp Glu His Lys Leu Ile Ser Glu Lys Asp 
            420                 425                 430         


Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln Leu 
        435                 440                 445             


Arg Asn Ser Gly Ala 
    450             


<210>  28
<211>  416
<212>  PRT
<213>  Gallus gallus

<400>  28

Met Pro Leu Ser Ala Ser Leu Pro Ser Lys Asn Tyr Asp Tyr Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Phe Glu Glu Glu Glu Glu Asn Phe 
            20                  25                  30          


Tyr Leu Ala Ala Gln Gln Arg Gly Ser Glu Leu Gln Pro Pro Ala Pro 
        35                  40                  45              


Ser Glu Asp Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu 
    50                  55                  60                  


Ser Pro Ser Arg Arg Ser Ser Leu Ala Ala Ala Ser Cys Phe Pro Ser 
65                  70                  75                  80  


Thr Ala Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met 
                85                  90                  95      


Val Asn Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Ser Phe Val Lys 
            100                 105                 110         


Ser Ile Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala 
        115                 120                 125             


Lys Leu Glu Lys Val Val Ser Glu Lys Leu Ala Thr Tyr Gln Ala Ser 
    130                 135                 140                 


Arg Arg Glu Gly Gly Pro Ala Ala Ala Ser Arg Pro Gly Pro Pro Pro 
145                 150                 155                 160 


Ser Gly Pro Pro Pro Pro Pro Ala Gly Pro Ala Ala Ser Ala Gly Leu 
                165                 170                 175     


Tyr Leu His Asp Leu Gly Ala Ala Ala Ala Asp Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Ser Glu Arg Ala Pro Arg Ala Ala Pro 
        195                 200                 205             


Pro Gly Ala Asn Pro Ala Ala Leu Leu Gly Val Asp Thr Pro Pro Thr 
    210                 215                 220                 


Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu Glu Asp Glu Glu Ile Asp 
225                 230                 235                 240 


Val Val Thr Leu Ala Glu Ala Asn Glu Ser Glu Ser Ser Thr Glu Ser 
                245                 250                 255     


Ser Thr Glu Ala Ser Glu Glu His Cys Lys Pro His His Ser Pro Leu 
            260                 265                 270         


Val Leu Lys Arg Cys His Val Asn Ile His Gln His Asn Tyr Ala Ala 
        275                 280                 285             


Pro Pro Ser Thr Lys Val Glu Tyr Pro Ala Ala Lys Arg Leu Lys Leu 
    290                 295                 300                 


Asp Ser Gly Arg Val Leu Lys Gln Ile Ser Asn Asn Arg Lys Cys Ser 
305                 310                 315                 320 


Ser Pro Arg Thr Ser Asp Ser Glu Glu Asn Asp Lys Arg Arg Thr His 
                325                 330                 335     


Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu Lys Leu Ser Phe Phe 
            340                 345                 350         


Ala Leu Arg Asp Gln Ile Pro Glu Val Ala Asn Asn Glu Lys Ala Pro 
        355                 360                 365             


Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val Leu Ser Ile Gln 
    370                 375                 380                 


Ser Asp Glu His Arg Leu Ile Ala Glu Lys Glu Gln Leu Arg Arg Arg 
385                 390                 395                 400 


Arg Glu Gln Leu Lys His Lys Leu Glu Gln Leu Arg Asn Ser Arg Ala 
                405                 410                 415     


<210>  29
<211>  419
<212>  PRT
<213>  Danio rerio

<400>  29

Met Glu Arg His Ser Leu Asn Thr Ser Val Lys Met Pro Val Ser Ala 
1               5                   10                  15      


Ser Leu Ala Cys Lys Asn Tyr Asp Tyr Asp Tyr Asp Ser Ile Gln Pro 
            20                  25                  30          


Tyr Phe Tyr Phe Asp Asn Asp Asp Glu Asp Phe Tyr His His Gln Gln 
        35                  40                  45              


Gly Gln Thr Gln Pro Ser Ala Pro Ser Glu Asp Ile Trp Lys Lys Phe 
    50                  55                  60                  


Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg Gln Ser Leu 
65                  70                  75                  80  


Ser Thr Ala Glu Gln Leu Glu Met Val Ser Glu Phe Leu Gly Asp Asp 
                85                  90                  95      


Val Val Ser Gln Ser Phe Ile Cys Asp Asp Ala Asp Tyr Ser Gln Ser 
            100                 105                 110         


Phe Ile Lys Ser Ile Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser 
        115                 120                 125             


Ala Ala Ala Lys Leu Glu Lys Val Val Ser Glu Arg Leu Ala Ser Leu 
    130                 135                 140                 


His Ala Glu Arg Lys Glu Leu Met Ser Asp Ser Asn Ser Asn Arg Leu 
145                 150                 155                 160 


Asn Ala Ser Tyr Leu Gln Asp Leu Ser Thr Ser Ala Ser Glu Cys Ile 
                165                 170                 175     


Asp Pro Ser Val Val Phe Pro Tyr Pro Leu Thr Glu Cys Gly Lys Ala 
            180                 185                 190         


Gly Lys Val Ala Ser Pro Gln Pro Met Leu Val Leu Asp Thr Pro Pro 
        195                 200                 205             


Asn Ser Ser Ser Ser Ser Gly Ser Asp Ser Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
225                 230                 235                 240 


Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Gln Lys Arg His 
                245                 250                 255     


Glu Thr Asp Ala Ser Glu Ser Arg Tyr Pro Ser Pro Leu Val Leu Lys 
            260                 265                 270         


Arg Cys His Val Ser Thr His Gln His Asn Tyr Ala Ala His Pro Ser 
        275                 280                 285             


Thr Arg His Asp Gln Pro Ala Val Lys Arg Leu Arg Leu Glu Ala Ser 
    290                 295                 300                 


Asn Asn His Ser Ile Asn Ser Ser Ser Ser Asn Arg His Val Lys Gln 
305                 310                 315                 320 


Arg Lys Cys Ala Ser Pro Arg Thr Ser Asp Ser Glu Asp Asn Asp Lys 
                325                 330                 335     


Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu Lys 
            340                 345                 350         


Leu Ser Phe Phe Ala Leu Arg Asp Glu Ile Pro Glu Val Ala Asn Asn 
        355                 360                 365             


Glu Lys Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Cys Ile 
    370                 375                 380                 


His Ser Met Gln Leu Asp Glu Gln Arg Leu Leu Ser Ile Lys Glu Gln 
385                 390                 395                 400 


Leu Arg Arg Lys Ser Glu Gln Leu Lys His Arg Leu Gln Gln Leu Arg 
                405                 410                 415     


Ser Ser His 
            


<210>  30
<211>  396
<212>  PRT
<213>  Danio rerio

<400>  30

Met Pro Leu Asn Ser Ser Met Glu Cys Lys Asn Tyr Asp Tyr Asp Tyr 
1               5                   10                  15      


Asp Ser Tyr Gln Pro Tyr Phe Tyr Phe Asp Asn Glu Asp Glu Asp Phe 
            20                  25                  30          


Tyr Asn His Gln His Gly Gln Pro Pro Ala Pro Ser Glu Asp Ile Trp 
        35                  40                  45              


Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg 
    50                  55                  60                  


Pro Ser Leu Ser Asp Pro Phe Pro Ser Thr Ala Asp Lys Leu Glu Met 
65                  70                  75                  80  


Val Ser Glu Phe Leu Gly Asp Asp Val Val Asn His Ser Ile Ile Cys 
                85                  90                  95      


Asp Ala Asp Tyr Ser Gln Ser Phe Leu Lys Ser Ile Ile Ile Gln Asp 
            100                 105                 110         


Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Glu Lys Val Val 
        115                 120                 125             


Ser Glu Arg Leu Ala Ser Leu Gln Ala Ala Arg Lys Glu Ser Ser Arg 
    130                 135                 140                 


Thr Glu Ser Ala Asp Ile Cys Arg Ser Val Gly Phe Leu Gln Asp Met 
145                 150                 155                 160 


Ser Thr Pro Ala Ser Gln Cys Ile Asp Pro Ser Val Val Phe Pro Phe 
                165                 170                 175     


Pro Leu Thr Asp Ser Thr Lys Pro Cys Lys Pro Ala Pro Thr Pro Ala 
            180                 185                 190         


Ser Thr Thr Leu Pro Leu Asp Thr Pro Pro Asn Ser Gly Ser Ser Ser 
        195                 200                 205             


Ser Ser Ser Asp Ser Glu Ser Asp Asp Glu Asp Asp Glu Asp Glu Glu 
    210                 215                 220                 


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Lys Ser Val 
225                 230                 235                 240 


Lys Lys Ser Asp Ala Asn Ala Thr His Gln Ser Pro Val Val Leu Lys 
                245                 250                 255     


Arg Cys His Val Asn Ile His Gln His Asn Tyr Ala Ala His Pro Ser 
            260                 265                 270         


Thr Arg Asn Glu Gln Pro Ala Val Lys Arg Ile Lys Phe Glu Ser His 
        275                 280                 285             


Ile Arg Val Phe Lys Gln Ile Ser His Asn Arg Lys Cys Ala Ser Pro 
    290                 295                 300                 


Arg Thr Ser Asp Ser Glu Asp Asn Asp Lys Arg Arg Thr His Asn Val 
305                 310                 315                 320 


Leu Glu Arg Gln Arg Arg Asn Glu Leu Lys Leu Ser Phe Phe Ala Leu 
                325                 330                 335     


Arg Asp Val Ile Pro Asp Val Ala Asn Asn Glu Lys Ala Ala Lys Val 
            340                 345                 350         


Val Ile Leu Lys Lys Ala Thr Glu Cys Ile Ala Ser Met Gln Glu Asp 
        355                 360                 365             


Glu Gln Arg Leu Ile Ser Leu Lys Glu Gln Leu Arg Arg Lys Cys Glu 
    370                 375                 380                 


His Leu Lys Gln Arg Leu Glu Gln Leu Ser Cys Ser 
385                 390                 395     


<210>  31
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
gccagcctga cccatagcca taatat                                            26


<210>  32
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  32
gagagatttt atgggtgtaa tgcgg                                             25


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  33
caccaaaccc acagaaaaca g                                                 21


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
gggtcagagg aagagataaa gttg                                              24


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
aatgtccgca gtgatgtcc                                                    19


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
gcctgagttt gtgtttgctg                                                   20


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  37
tgaagttcgc attttgatgg c                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  38
ctttggtcct ggcatctcta c                                                 21


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  39
cacccagatg caaaactttc ag                                                22


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
ctgctcttta tacttgctca cag                                               23


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  41
atagagccca agatcaagca g                                                 21


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  42
tgtaacagcc ttccagtgc                                                    19


<210>  43
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  43
accaaaaccc atcccgtc                                                     18


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  44
tctgtaaggg ctccaaatgt g                                                 21


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  45
gttcataggg tcagaggtca ag                                                22


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  46
tccattaaga tgtcctgtgc g                                                 21


<210>  47
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  47
accccttctc tgtctaccg                                                    19


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  48
aatgctcgct tctccttgta g                                                 21


<210>  49
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  49
atcaaggcac tgtccaagg                                                    19


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  50
tcattttcct gcatctcccg                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  51
accctaatct agtcccgtcc                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  52
cagccaaaac cagatgacag                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  53
cattggtgat ggtattgcgc                                                   20


<210>  54
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  54
tcccaaacac gacaactcc                                                    19


<210>  55
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  55
ggaccgagtt ctgtatgtct tg                                                22


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  56
aaacccaaat tcgtcttcca tg                                                22


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  57
cttgaatccc tgctctgtgg                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  58
aaagctgaga gtgccaagag                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  59
ttccagtgca gatgtccaag                                                   20


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  60
ctgttgaagg acggtagaag g                                                 21


<210>  61
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  61
gttcgttgcc taccctcac                                                    19


<210>  62
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  62
tctctttact catcttcata gccg                                              24


<210>  63
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  63
ccgtgagggc aatgatttat ac                                                22


<210>  64
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  64
gtcaaaccag tcagagctac c                                                 21


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  65
tgcacctacc ctatcactca                                                   20


<210>  66
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  66
ggctcatcct gatcatagaa tgg                                               23


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  67
cccaccccat attaaacccg                                                   20


<210>  68
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  68
gaggtatgaa ggaaaggtat aaggg                                             25


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  69
cccagatata gcattcccac g                                                 21


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  70
actgttcatc ctgttcctgc                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  71
tcccaatcgt tgtagccatc                                                   20


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  72
tgttggaaag aatggagtcg g                                                 21


<210>  73
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  73
atactagcaa ttacttctat tttcataggg                                        30


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  74
gagggatggg ttgtaaggaa g                                                 21


<210>  75
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  75
aagcaaatcc atatgaatgc gg                                                22


<210>  76
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  76
gctcatggta gtggaagtag aag                                               23


<210>  77
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  77
catcactcct attctgccta gc                                                22


<210>  78
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  78
ccaactccat aagctccata cc                                                22


<210>  79
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  79
ccaactccat aagctccata cc                                                22


<210>  80
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  80
gattttggac gtaatctgtt ccg                                               23


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  81
acgaaaatga cccagacctc                                                   20


<210>  82
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  82
gagatgacaa atcctgcaaa gatg                                              24


<210>  83
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  83
tgttggagtt atgttggaag gag                                               23


<210>  84
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  84
caaagatcac ccagctacta cc                                                22


<210>  85
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  85
agttgataac cgagtcgttc tg                                                22


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  86
ctgttgcttg atttagtcgg c                                                 21


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  87
cgtgaaggaa cctaccaagg                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  88
cgctcagaag aatcctgcaa                                                   20


<210>  89
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  89
gccacaacta gatacatcaa catg                                              24


<210>  90
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  90
tggttgttag tgattttggt gaag                                              24


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  91
gaacatcaag tcagcaacgt g                                                 21


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  92
tttgacggat gaggaatggg                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  93
cgagaatggc tgtggatgag                                                   20


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  94
ggatggtgtt ggacagtgta g                                                 21


<210>  95
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  95
gctccccaga acaagattac ag                                                22


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  96
tcgcccttga gtttgtcttc                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  97
tcaaagagaa caagggcgag                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  98
aggaagcgga catcacaatc                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  99
tgcagcccaa ggatctctct                                                   20


<210>  100
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  100
cggcttgccc gagatct                                                      17


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  101
ccattctcta ccgtcctgtt g                                                 21


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  102
tccatgtaag cgttgtccag                                                   20


<210>  103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  103
ggcagcttga gttaaacgaa c                                                 21


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  104
tggtgacatg gttaatcggt c                                                 21


<210>  105
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  105
gactgtgaag atgagtgacc g                                                 21


<210>  106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  106
caatccgtaa ccaaacccag                                                   20


<210>  107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  107
aacctccgct ttcatgtaga g                                                 21


<210>  108
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  108
gacatctcct agtttggaca gtg                                               23


<210>  109
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  109
gatggctttg agggtctgg                                                    19


<210>  110
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  110
cttggttatg ttggcactga tc                                                22


<210>  111
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  111
tgtgttaggg gactggtgga ca                                                22


<210>  112
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  112
catcacccac ttacccccaa aa                                                22


<210>  113
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  113
ataaccgagt cgttctgcca at                                                22


<210>  114
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  114
tttcagagca ttggccatag aa                                                22


