                               SEQUENCE LISTING

<110> BRANDEIS UNIVERSITY
 
<120> TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

<130> 2004952-0038

<140> PCT/US2013/063858
<141> 2013-10-08

<150> 61/712,322
<151> 2012-10-11

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 3357
<212> DNA
<213> Homo sapiens

<400> 1
atgagcgtgg aggcgtacgg gcccagctcg cagactctca ctttcctgga cacggaggag       60

gccgagctgc ttggcgccga cacacagggc tccgagttcg agttcaccga ctttactctt      120

cctagccaga cgcagacgcc ccccggcggc cccggcggcc cgggcggtgg cggcgcggga      180

agcccgggcg gcgcgggcgc cggcgctgcg gcgggacagc tcgacgcgca ggttgggccc      240

gaaggcatcc tgcagaacgg ggctgtggac gacagtgtag ccaagaccag ccagttgttg      300

gctgagttga acttcgagga agatgaagaa gacacctatt acacgaagga cctccccata      360

cacgcctgca gttactgtgg aatacacgat cctgcctgcg tggtttactg taataccagc      420

aagaagtggt tctgcaacgg acgtggaaat acttctggca gccacattgt aaatcacctt      480

gtgagggcaa aatgcaaaga ggtgaccctg cacaaggacg ggcccctggg ggagacagtc      540

ctggagtgct acaactgcgg ctgtcgcaac gtcttcctcc tcggcttcat cccggccaaa      600

gctgactcag tggtggtgct gctgtgcagg cagccctgtg ccagccagag cagcctcaag      660

gacatcaact gggacagctc gcagtggcag ccgctgatcc aggaccgctg cttcctgtcc      720

tggctggtca agatcccctc cgagcaggag cagctgcggg cacgccagat cacggcacag      780

cagatcaaca agctggagga gctgtggaag gaaaaccctt ctgccacgct ggaggacctg      840

gagaagccgg gggtggacga ggagccgcag catgtcctcc tgcggtacga ggacgcctac      900

cagtaccaga acatattcgg gcccctggtc aagctggagg ccgactacga caagaagctg      960

aaggagtccc agactcaaga taacatcact gtcaggtggg acctgggcct taacaagaag     1020

agaatcgcct acttcacttt gcccaagact gactctgaca tgcggctcat gcagggggat     1080

gagatatgcc tgcggtacaa aggggacctt gcgcccctgt ggaaagggat cggccacgtc     1140

atcaaggtcc ctgataatta tggcgatgag atcgccattg agctgcggag cagcgtgggt     1200

gcacctgtgg aggtgactca caacttccag gtggattttg tgtggaagtc gacctccttt     1260

gacaggatgc agagcgcatt gaaaacgttt gccgtggatg agacctcggt gtctggctac     1320

atctaccaca agctgttggg ccacgaggtg gaggacgtaa tcaccaagtg ccagctgccc     1380

aagcgcttca cggcgcaggg cctccccgac ctcaaccact cccaggttta tgccgtgaag     1440

actgtgctgc aaagaccact gagcctgatc cagggcccgc caggcacggg gaagacggtg     1500

acgtcggcca ccatcgtcta ccacctggcc cggcaaggca acgggccggt gctggtgtgt     1560

gctccgagca acatcgccgt ggaccagcta acggagaaga tccaccagac ggggctaaag     1620

gtcgtgcgcc tctgcgccaa gagccgtgag gccatcgact ccccggtgtc ttttctggcc     1680

ctgcacaacc agatcaggaa catggacagc atgcctgagc tgcagaagct gcagcagctg     1740

aaagacgaga ctggggagct gtcgtctgcc gacgagaagc ggtaccgggc cttgaagcgc     1800

accgcagaga gagagctgct gatgaacgca gatgtcatct gctgcacatg tgtgggcgcc     1860

ggtgacccga ggctggccaa gatgcagttc cgctccattt taatcgacga aagcacccag     1920

gccaccgagc cggagtgcat ggttcccgtg gtcctcgggg ccaagcagct gatccttgta     1980

ggcgaccact gccagctggg cccagtggtg atgtgcaaga aggcggccaa ggccgggctg     2040

tcacagtcgc tcttcgagcg cctggtggtg ctgggcatcc ggcccatccg cctgcaggtc     2100

cagtaccgga tgcaccctgc actcagcgcc ttcccatcca acatcttcta cgagggctcc     2160

ctccagaatg gtgtcactgc agcggatcgt gtgaagaagg gatttgactt ccagtggccc     2220

caacccgata aaccgatgtt cttctacgtg acccagggcc aagaggagat tgccagctcg     2280

ggcacctcct acctgaacag gaccgaggct gcgaacgtgg agaagatcac cacgaagttg     2340

ctgaaggcag gcgccaagcc ggaccagatt ggcatcatca cgccctacga gggccagcgc     2400

tcctacctgg tgcagtacat gcagttcagc ggctccctgc acaccaagct ctaccaggaa     2460

gtggagatcg ccagtgtgga cgcctttcag ggacgcgaga aggacttcat catcctgtcc     2520

tgtgtgcggg ccaacgagca ccaaggcatt ggctttttaa atgaccccag gcgtctgaac     2580

gtggccctga ccagagcaag gtatggcgtc atcattgtgg gcaacccgaa ggcactatca     2640

aagcagccgc tctggaacca cctgctgaac tactataagg agcagaaggt gctggtggag     2700

gggccgctca acaacctgcg tgagagcctc atgcagttca gcaagccacg gaagctggtc     2760

aacactatca acccgggagc ccgcttcatg accacagcca tgtatgatgc ccgggaggcc     2820

atcatcccag gctccgtcta tgatcggagc agccagggcc ggccttccag catgtacttc     2880

cagacccatg accagattgg catgatcagt gccggcccta gccacgtggc tgccatgaac     2940

attcccatcc ccttcaacct ggtcatgcca cccatgccac cgcctggcta ttttggacaa     3000

gccaacgggc ctgctgcagg gcgaggcacc ccgaaaggca agactggtcg tgggggacgc     3060

cagaagaacc gctttgggct tcctggaccc agccagacta acctccccaa cagccaagcc     3120

agccaggatg tggcgtcaca gcccttctct cagggcgccc tgacgcaggg ctacatctcc     3180

atgagccagc cttcccagat gagccagccc ggcctctccc agccggagct gtcccaggac     3240

agttaccttg gtgacgagtt taaatcacaa atcgacgtgg cgctctcaca ggactccacg     3300

taccagggag agcgggctta ccagcatggc ggggtgacgg ggctgtccca gtattaa        3357


<210> 2
<211> 1118
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Val Glu Ala Tyr Gly Pro Ser Ser Gln Thr Leu Thr Phe Leu 
1               5                   10                  15      


Asp Thr Glu Glu Ala Glu Leu Leu Gly Ala Asp Thr Gln Gly Ser Glu 
            20                  25                  30          


Phe Glu Phe Thr Asp Phe Thr Leu Pro Ser Gln Thr Gln Thr Pro Pro 
        35                  40                  45              


Gly Gly Pro Gly Gly Pro Gly Gly Gly Gly Ala Gly Ser Pro Gly Gly 
    50                  55                  60                  


Ala Gly Ala Gly Ala Ala Ala Gly Gln Leu Asp Ala Gln Val Gly Pro 
65                  70                  75                  80  


Glu Gly Ile Leu Gln Asn Gly Ala Val Asp Asp Ser Val Ala Lys Thr 
                85                  90                  95      


Ser Gln Leu Leu Ala Glu Leu Asn Phe Glu Glu Asp Glu Glu Asp Thr 
            100                 105                 110         


Tyr Tyr Thr Lys Asp Leu Pro Ile His Ala Cys Ser Tyr Cys Gly Ile 
        115                 120                 125             


His Asp Pro Ala Cys Val Val Tyr Cys Asn Thr Ser Lys Lys Trp Phe 
    130                 135                 140                 


Cys Asn Gly Arg Gly Asn Thr Ser Gly Ser His Ile Val Asn His Leu 
145                 150                 155                 160 


Val Arg Ala Lys Cys Lys Glu Val Thr Leu His Lys Asp Gly Pro Leu 
                165                 170                 175     


Gly Glu Thr Val Leu Glu Cys Tyr Asn Cys Gly Cys Arg Asn Val Phe 
            180                 185                 190         


Leu Leu Gly Phe Ile Pro Ala Lys Ala Asp Ser Val Val Val Leu Leu 
        195                 200                 205             


Cys Arg Gln Pro Cys Ala Ser Gln Ser Ser Leu Lys Asp Ile Asn Trp 
    210                 215                 220                 


Asp Ser Ser Gln Trp Gln Pro Leu Ile Gln Asp Arg Cys Phe Leu Ser 
225                 230                 235                 240 


Trp Leu Val Lys Ile Pro Ser Glu Gln Glu Gln Leu Arg Ala Arg Gln 
                245                 250                 255     


Ile Thr Ala Gln Gln Ile Asn Lys Leu Glu Glu Leu Trp Lys Glu Asn 
            260                 265                 270         


Pro Ser Ala Thr Leu Glu Asp Leu Glu Lys Pro Gly Val Asp Glu Glu 
        275                 280                 285             


Pro Gln His Val Leu Leu Arg Tyr Glu Asp Ala Tyr Gln Tyr Gln Asn 
    290                 295                 300                 


Ile Phe Gly Pro Leu Val Lys Leu Glu Ala Asp Tyr Asp Lys Lys Leu 
305                 310                 315                 320 


Lys Glu Ser Gln Thr Gln Asp Asn Ile Thr Val Arg Trp Asp Leu Gly 
                325                 330                 335     


Leu Asn Lys Lys Arg Ile Ala Tyr Phe Thr Leu Pro Lys Thr Asp Ser 
            340                 345                 350         


Asp Met Arg Leu Met Gln Gly Asp Glu Ile Cys Leu Arg Tyr Lys Gly 
        355                 360                 365             


Asp Leu Ala Pro Leu Trp Lys Gly Ile Gly His Val Ile Lys Val Pro 
    370                 375                 380                 


Asp Asn Tyr Gly Asp Glu Ile Ala Ile Glu Leu Arg Ser Ser Val Gly 
385                 390                 395                 400 


Ala Pro Val Glu Val Thr His Asn Phe Gln Val Asp Phe Val Trp Lys 
                405                 410                 415     


Ser Thr Ser Phe Asp Arg Met Gln Ser Ala Leu Lys Thr Phe Ala Val 
            420                 425                 430         


Asp Glu Thr Ser Val Ser Gly Tyr Ile Tyr His Lys Leu Leu Gly His 
        435                 440                 445             


Glu Val Glu Asp Val Ile Thr Lys Cys Gln Leu Pro Lys Arg Phe Thr 
    450                 455                 460                 


Ala Gln Gly Leu Pro Asp Leu Asn His Ser Gln Val Tyr Ala Val Lys 
465                 470                 475                 480 


Thr Val Leu Gln Arg Pro Leu Ser Leu Ile Gln Gly Pro Pro Gly Thr 
                485                 490                 495     


Gly Lys Thr Val Thr Ser Ala Thr Ile Val Tyr His Leu Ala Arg Gln 
            500                 505                 510         


Gly Asn Gly Pro Val Leu Val Cys Ala Pro Ser Asn Ile Ala Val Asp 
        515                 520                 525             


Gln Leu Thr Glu Lys Ile His Gln Thr Gly Leu Lys Val Val Arg Leu 
    530                 535                 540                 


Cys Ala Lys Ser Arg Glu Ala Ile Asp Ser Pro Val Ser Phe Leu Ala 
545                 550                 555                 560 


Leu His Asn Gln Ile Arg Asn Met Asp Ser Met Pro Glu Leu Gln Lys 
                565                 570                 575     


Leu Gln Gln Leu Lys Asp Glu Thr Gly Glu Leu Ser Ser Ala Asp Glu 
            580                 585                 590         


Lys Arg Tyr Arg Ala Leu Lys Arg Thr Ala Glu Arg Glu Leu Leu Met 
        595                 600                 605             


Asn Ala Asp Val Ile Cys Cys Thr Cys Val Gly Ala Gly Asp Pro Arg 
    610                 615                 620                 


Leu Ala Lys Met Gln Phe Arg Ser Ile Leu Ile Asp Glu Ser Thr Gln 
625                 630                 635                 640 


Ala Thr Glu Pro Glu Cys Met Val Pro Val Val Leu Gly Ala Lys Gln 
                645                 650                 655     


Leu Ile Leu Val Gly Asp His Cys Gln Leu Gly Pro Val Val Met Cys 
            660                 665                 670         


Lys Lys Ala Ala Lys Ala Gly Leu Ser Gln Ser Leu Phe Glu Arg Leu 
        675                 680                 685             


Val Val Leu Gly Ile Arg Pro Ile Arg Leu Gln Val Gln Tyr Arg Met 
    690                 695                 700                 


His Pro Ala Leu Ser Ala Phe Pro Ser Asn Ile Phe Tyr Glu Gly Ser 
705                 710                 715                 720 


Leu Gln Asn Gly Val Thr Ala Ala Asp Arg Val Lys Lys Gly Phe Asp 
                725                 730                 735     


Phe Gln Trp Pro Gln Pro Asp Lys Pro Met Phe Phe Tyr Val Thr Gln 
            740                 745                 750         


Gly Gln Glu Glu Ile Ala Ser Ser Gly Thr Ser Tyr Leu Asn Arg Thr 
        755                 760                 765             


Glu Ala Ala Asn Val Glu Lys Ile Thr Thr Lys Leu Leu Lys Ala Gly 
    770                 775                 780                 


Ala Lys Pro Asp Gln Ile Gly Ile Ile Thr Pro Tyr Glu Gly Gln Arg 
785                 790                 795                 800 


Ser Tyr Leu Val Gln Tyr Met Gln Phe Ser Gly Ser Leu His Thr Lys 
                805                 810                 815     


Leu Tyr Gln Glu Val Glu Ile Ala Ser Val Asp Ala Phe Gln Gly Arg 
            820                 825                 830         


Glu Lys Asp Phe Ile Ile Leu Ser Cys Val Arg Ala Asn Glu His Gln 
        835                 840                 845             


Gly Ile Gly Phe Leu Asn Asp Pro Arg Arg Leu Asn Val Ala Leu Thr 
    850                 855                 860                 


Arg Ala Arg Tyr Gly Val Ile Ile Val Gly Asn Pro Lys Ala Leu Ser 
865                 870                 875                 880 


Lys Gln Pro Leu Trp Asn His Leu Leu Asn Tyr Tyr Lys Glu Gln Lys 
                885                 890                 895     


Val Leu Val Glu Gly Pro Leu Asn Asn Leu Arg Glu Ser Leu Met Gln 
            900                 905                 910         


Phe Ser Lys Pro Arg Lys Leu Val Asn Thr Ile Asn Pro Gly Ala Arg 
        915                 920                 925             


Phe Met Thr Thr Ala Met Tyr Asp Ala Arg Glu Ala Ile Ile Pro Gly 
    930                 935                 940                 


Ser Val Tyr Asp Arg Ser Ser Gln Gly Arg Pro Ser Ser Met Tyr Phe 
945                 950                 955                 960 


Gln Thr His Asp Gln Ile Gly Met Ile Ser Ala Gly Pro Ser His Val 
                965                 970                 975     


Ala Ala Met Asn Ile Pro Ile Pro Phe Asn Leu Val Met Pro Pro Met 
            980                 985                 990         


Pro Pro Pro Gly Tyr Phe Gly Gln  Ala Asn Gly Pro Ala  Ala Gly Arg 
        995                 1000                 1005             


Gly Thr  Pro Lys Gly Lys Thr  Gly Arg Gly Gly Arg  Gln Lys Asn 
    1010                 1015                 1020             


Arg Phe  Gly Leu Pro Gly Pro  Ser Gln Thr Asn Leu  Pro Asn Ser 
    1025                 1030                 1035             


Gln Ala  Ser Gln Asp Val Ala  Ser Gln Pro Phe Ser  Gln Gly Ala 
    1040                 1045                 1050             


Leu Thr  Gln Gly Tyr Ile Ser  Met Ser Gln Pro Ser  Gln Met Ser 
    1055                 1060                 1065             


Gln Pro  Gly Leu Ser Gln Pro  Glu Leu Ser Gln Asp  Ser Tyr Leu 
    1070                 1075                 1080             


Gly Asp  Glu Phe Lys Ser Gln  Ile Asp Val Ala Leu  Ser Gln Asp 
    1085                 1090                 1095             


Ser Thr  Tyr Gln Gly Glu Arg  Ala Tyr Gln His Gly  Gly Val Thr 
    1100                 1105                 1110             


Gly Leu  Ser Gln Tyr 
    1115             


<210> 3
<211> 3819
<212> DNA
<213> Homo sapiens

<400> 3
atgccagctg agcgtaaaaa gccagcaagt atggaagaaa aagactcttt accaaacaac       60

aaggaaaaag actgcagtga aaggcggaca gtgagcagca aggagaggcc aaaagacgat      120

atcaagctca ctgccaagaa ggaggtcagc aaggcccctg aagacaagaa gaagagactg      180

gaagatgata agagaaaaaa ggaagacaag gaacgcaaga aaaaagacga agaaaaggtg      240

aaggcagagg aagaatcaaa gaaaaaagaa gaggaagaaa aaaagaaaca tcaagaggaa      300

gagagaaaga agcaagaaga gcaggccaaa cgtcagcaag aagaagaagc agctgctcag      360

atgaaagaaa aagaagaatc cattcagctt catcaggaag cttgggaacg acatcattta      420

agaaaggaac ttcgtagcaa aaaccaaaat gctccggaca gccgaccaga ggaaaacttc      480

ttcagccgcc tcgactcaag tttgaagaaa aatactgctt ttgtcaagaa actaaaaact      540

attacagaac aacagagaga ctccttgtcc catgatttta atggcctaaa tttaagcaaa      600

tacattgcag aagctgtagc ttccatcgtg gaagcaaaac taaaaatctc tgatgtgaac      660

tgtgctgtgc acctctgctc tctctttcac cagcgttatg ctgactttgc cccatcactt      720

cttcaggtct ggaaaaaaca ttttgaagca aggaaagagg agaaaacacc taacatcacc      780

aagttaagaa ctgatttgcg ttttattgca gaattgacaa tagttgggat tttcactgac      840

aaggaaggtc tttccttaat ctatgaacag ctaaaaaata ttattaatgc tgatcgggag      900

tcccacactc atgtctctgt agtgattagt ttctgtcgac attgtggaga tgatattgct      960

ggacttgtac caaggaaagt aaagagtgct gcagagaagt ttaatttgag ttttcctcct     1020

agtgagataa ttagtccaga gaaacaacag cccttccaga atcttttaaa agagtacttt     1080

acgtctttga ccaaacacct gaaaagggac cacagggagc tccagaatac tgagagacaa     1140

aacaggcgca ttctacattc taaaggggag ctcagtgaag atagacataa acagtatgag     1200

gaatttgcta tgtcttacca gaagctgctg gcaaattctc aatccttagc agaccttttg     1260

gatgaaaata tgccagatct tcctcaagac aaacccacac cagaagaaca tgggcctgga     1320

attgatatat tcacacctgg taaacctgga gaatatgact tggaaggtgg tatatgggaa     1380

gatgaagatg ctcggaattt ttatgagaac ctcattgatt tgaaggcttt tgtcccagcc     1440

atcttgttta aagacaatga aaaaagttgt cagaataaag agtccaacaa agatgatacc     1500

aaagaggcaa aagaatctaa ggagaataag gaggtatcaa gtcccgatga tttggaactt     1560

gagttggaga atctagaaat taatgatgac accttagaat tagagggtgg agatgaagct     1620

gaagatctta caaagaaact tcttgatgaa caagaacaag aagatgagga agccagcact     1680

ggatctcatc tcaagctcat agtagatgct ttcctacagc agttacccaa ctgtgtcaac     1740

cgagatctga tagacaaggc agcaatggat ttttgcatga acatgaacac aaaagcaaac     1800

aggaagaagt tggtacgggc actcttcata gttcctagac aaaggttgga tttgctacca     1860

ttttatgcaa gattggttgc tacattgcat ccctgcatgt ctgatgtagc agaggatctt     1920

tgttccatgc tgagggggga tttcagattt catgtacgga aaaaggacca gatcaatatt     1980

gaaacaaaga ataaaactgt tcgttttata ggagaactaa ctaagtttaa gatgttcacc     2040

aaaaatgaca cactgcattg tttaaagatg cttctgtcag acttctctca tcaccatatt     2100

gaaatggcat gcaccctgct ggagacatgt ggacggtttc ttttcagatc tccagaatct     2160

cacctgagga ccagtgtact tttggagcaa atgatgagaa agaagcaagc aatgcatctt     2220

gatgcgagat acgtcacaat ggtagagaat gcatattact actgcaaccc acctccagct     2280

gaaaaaaccg tgaaaaagaa acgtcctcct ctccaggaat atgtccggaa acttttgtac     2340

aaagatctct ctaaggttac caccgagaag gttttgagac agatgcgaaa gctgccctgg     2400

caggaccaag aagtgaaaga ctatgttatt tgttgtatga taaacatctg gaatgtgaaa     2460

tataatagta ttcattgtgt agccaacctc ttagcaggac tagtgctcta ccaagaggat     2520

gttgggatcc acgttgtgga tggagtgtta gaagatattc gattaggaat ggaggttaat     2580

caacctaaat ttaatcagag gcgcatcagc agtgccaagt tcttaggaga actttacaat     2640

taccgaatgg tggaatcagc tgttattttc agaactctgt attcttttac ctcatttggt     2700

gttaatcctg atggctctcc aagttccctg gacccacctg agcatctttt cagaattaga     2760

ctcgtatgca ctattctgga cacatgtggc cagtactttg acagaggttc cagtaaacga     2820

aaacttgatt gtttccttgt atattttcag cgttatgttt ggtggaagaa aagtttggag     2880

gtttggacaa aagaccatcc atttcctatt gatatagatt acatgatcag tgatacacta     2940

gaactgctaa gaccaaagat caaactctgt aattctctgg aagaatccat caggcaggta     3000

caagacttgg aacgagaatt cttaataaaa ctaggcctag taaatgacaa agactcaaaa     3060

gattctatga cagaaggaga aaatcttgaa gaggatgaag aagaagaaga aggtggggct     3120

gaaacagaag aacaatctgg aaatgaaagt gaagtaaatg agccagaaga agaggagggt     3180

tctgataatg atgatgatga gggagaagaa gaggaggaag agaatacaga ttaccttaca     3240

gattccaata aggaaaatga aaccgatgaa gagaatactg aggtaatgat taaaggcggt     3300

ggacttaagc atgtaccttg tgtagaagat gaggacttca ttcaagctct ggataaaatg     3360

atgctagaaa atctacagca acgaagtggt gaatctgtta aagtgcacca actagatgtg     3420

gccattcctt tgcatctcaa aagccagctg aggaaagggc ccccactggg aggtggggaa     3480

ggagaggctg agtctgcaga cacaatgccg tttgtcatgt taacaagaaa aggcaataaa     3540

cagcagttta agatccttaa tgtacccatg tcctctcaac ttgctgcaaa tcactggaac     3600

cagcaacagg cagaacaaga agagaggatg agaatgaaga agctcacact agatatcaat     3660

gaacggcaag aacaagaaga ttatcaagaa atgttgcagt ctcttgcaca gcgcccagct     3720

ccagcaaaca ccaatcgtga gaggcggcct cgctaccaac atccgaaggg agcacctaat     3780

gcagatctaa tctttaagac tggtgggagg agacgttga                            3819


<210> 4
<211> 1272
<212> PRT
<213> Homo sapiens

<400> 4
Met Pro Ala Glu Arg Lys Lys Pro Ala Ser Met Glu Glu Lys Asp Ser 
1               5                   10                  15      


Leu Pro Asn Asn Lys Glu Lys Asp Cys Ser Glu Arg Arg Thr Val Ser 
            20                  25                  30          


Ser Lys Glu Arg Pro Lys Asp Asp Ile Lys Leu Thr Ala Lys Lys Glu 
        35                  40                  45              


Val Ser Lys Ala Pro Glu Asp Lys Lys Lys Arg Leu Glu Asp Asp Lys 
    50                  55                  60                  


Arg Lys Lys Glu Asp Lys Glu Arg Lys Lys Lys Asp Glu Glu Lys Val 
65                  70                  75                  80  


Lys Ala Glu Glu Glu Ser Lys Lys Lys Glu Glu Glu Glu Lys Lys Lys 
                85                  90                  95      


His Gln Glu Glu Glu Arg Lys Lys Gln Glu Glu Gln Ala Lys Arg Gln 
            100                 105                 110         


Gln Glu Glu Glu Ala Ala Ala Gln Met Lys Glu Lys Glu Glu Ser Ile 
        115                 120                 125             


Gln Leu His Gln Glu Ala Trp Glu Arg His His Leu Arg Lys Glu Leu 
    130                 135                 140                 


Arg Ser Lys Asn Gln Asn Ala Pro Asp Ser Arg Pro Glu Glu Asn Phe 
145                 150                 155                 160 


Phe Ser Arg Leu Asp Ser Ser Leu Lys Lys Asn Thr Ala Phe Val Lys 
                165                 170                 175     


Lys Leu Lys Thr Ile Thr Glu Gln Gln Arg Asp Ser Leu Ser His Asp 
            180                 185                 190         


Phe Asn Gly Leu Asn Leu Ser Lys Tyr Ile Ala Glu Ala Val Ala Ser 
        195                 200                 205             


Ile Val Glu Ala Lys Leu Lys Ile Ser Asp Val Asn Cys Ala Val His 
    210                 215                 220                 


Leu Cys Ser Leu Phe His Gln Arg Tyr Ala Asp Phe Ala Pro Ser Leu 
225                 230                 235                 240 


Leu Gln Val Trp Lys Lys His Phe Glu Ala Arg Lys Glu Glu Lys Thr 
                245                 250                 255     


Pro Asn Ile Thr Lys Leu Arg Thr Asp Leu Arg Phe Ile Ala Glu Leu 
            260                 265                 270         


Thr Ile Val Gly Ile Phe Thr Asp Lys Glu Gly Leu Ser Leu Ile Tyr 
        275                 280                 285             


Glu Gln Leu Lys Asn Ile Ile Asn Ala Asp Arg Glu Ser His Thr His 
    290                 295                 300                 


Val Ser Val Val Ile Ser Phe Cys Arg His Cys Gly Asp Asp Ile Ala 
305                 310                 315                 320 


Gly Leu Val Pro Arg Lys Val Lys Ser Ala Ala Glu Lys Phe Asn Leu 
                325                 330                 335     


Ser Phe Pro Pro Ser Glu Ile Ile Ser Pro Glu Lys Gln Gln Pro Phe 
            340                 345                 350         


Gln Asn Leu Leu Lys Glu Tyr Phe Thr Ser Leu Thr Lys His Leu Lys 
        355                 360                 365             


Arg Asp His Arg Glu Leu Gln Asn Thr Glu Arg Gln Asn Arg Arg Ile 
    370                 375                 380                 


Leu His Ser Lys Gly Glu Leu Ser Glu Asp Arg His Lys Gln Tyr Glu 
385                 390                 395                 400 


Glu Phe Ala Met Ser Tyr Gln Lys Leu Leu Ala Asn Ser Gln Ser Leu 
                405                 410                 415     


Ala Asp Leu Leu Asp Glu Asn Met Pro Asp Leu Pro Gln Asp Lys Pro 
            420                 425                 430         


Thr Pro Glu Glu His Gly Pro Gly Ile Asp Ile Phe Thr Pro Gly Lys 
        435                 440                 445             


Pro Gly Glu Tyr Asp Leu Glu Gly Gly Ile Trp Glu Asp Glu Asp Ala 
    450                 455                 460                 


Arg Asn Phe Tyr Glu Asn Leu Ile Asp Leu Lys Ala Phe Val Pro Ala 
465                 470                 475                 480 


Ile Leu Phe Lys Asp Asn Glu Lys Ser Cys Gln Asn Lys Glu Ser Asn 
                485                 490                 495     


Lys Asp Asp Thr Lys Glu Ala Lys Glu Ser Lys Glu Asn Lys Glu Val 
            500                 505                 510         


Ser Ser Pro Asp Asp Leu Glu Leu Glu Leu Glu Asn Leu Glu Ile Asn 
        515                 520                 525             


Asp Asp Thr Leu Glu Leu Glu Gly Gly Asp Glu Ala Glu Asp Leu Thr 
    530                 535                 540                 


Lys Lys Leu Leu Asp Glu Gln Glu Gln Glu Asp Glu Glu Ala Ser Thr 
545                 550                 555                 560 


Gly Ser His Leu Lys Leu Ile Val Asp Ala Phe Leu Gln Gln Leu Pro 
                565                 570                 575     


Asn Cys Val Asn Arg Asp Leu Ile Asp Lys Ala Ala Met Asp Phe Cys 
            580                 585                 590         


Met Asn Met Asn Thr Lys Ala Asn Arg Lys Lys Leu Val Arg Ala Leu 
        595                 600                 605             


Phe Ile Val Pro Arg Gln Arg Leu Asp Leu Leu Pro Phe Tyr Ala Arg 
    610                 615                 620                 


Leu Val Ala Thr Leu His Pro Cys Met Ser Asp Val Ala Glu Asp Leu 
625                 630                 635                 640 


Cys Ser Met Leu Arg Gly Asp Phe Arg Phe His Val Arg Lys Lys Asp 
                645                 650                 655     


Gln Ile Asn Ile Glu Thr Lys Asn Lys Thr Val Arg Phe Ile Gly Glu 
            660                 665                 670         


Leu Thr Lys Phe Lys Met Phe Thr Lys Asn Asp Thr Leu His Cys Leu 
        675                 680                 685             


Lys Met Leu Leu Ser Asp Phe Ser His His His Ile Glu Met Ala Cys 
    690                 695                 700                 


Thr Leu Leu Glu Thr Cys Gly Arg Phe Leu Phe Arg Ser Pro Glu Ser 
705                 710                 715                 720 


His Leu Arg Thr Ser Val Leu Leu Glu Gln Met Met Arg Lys Lys Gln 
                725                 730                 735     


Ala Met His Leu Asp Ala Arg Tyr Val Thr Met Val Glu Asn Ala Tyr 
            740                 745                 750         


Tyr Tyr Cys Asn Pro Pro Pro Ala Glu Lys Thr Val Lys Lys Lys Arg 
        755                 760                 765             


Pro Pro Leu Gln Glu Tyr Val Arg Lys Leu Leu Tyr Lys Asp Leu Ser 
    770                 775                 780                 


Lys Val Thr Thr Glu Lys Val Leu Arg Gln Met Arg Lys Leu Pro Trp 
785                 790                 795                 800 


Gln Asp Gln Glu Val Lys Asp Tyr Val Ile Cys Cys Met Ile Asn Ile 
                805                 810                 815     


Trp Asn Val Lys Tyr Asn Ser Ile His Cys Val Ala Asn Leu Leu Ala 
            820                 825                 830         


Gly Leu Val Leu Tyr Gln Glu Asp Val Gly Ile His Val Val Asp Gly 
        835                 840                 845             


Val Leu Glu Asp Ile Arg Leu Gly Met Glu Val Asn Gln Pro Lys Phe 
    850                 855                 860                 


Asn Gln Arg Arg Ile Ser Ser Ala Lys Phe Leu Gly Glu Leu Tyr Asn 
865                 870                 875                 880 


Tyr Arg Met Val Glu Ser Ala Val Ile Phe Arg Thr Leu Tyr Ser Phe 
                885                 890                 895     


Thr Ser Phe Gly Val Asn Pro Asp Gly Ser Pro Ser Ser Leu Asp Pro 
            900                 905                 910         


Pro Glu His Leu Phe Arg Ile Arg Leu Val Cys Thr Ile Leu Asp Thr 
        915                 920                 925             


Cys Gly Gln Tyr Phe Asp Arg Gly Ser Ser Lys Arg Lys Leu Asp Cys 
    930                 935                 940                 


Phe Leu Val Tyr Phe Gln Arg Tyr Val Trp Trp Lys Lys Ser Leu Glu 
945                 950                 955                 960 


Val Trp Thr Lys Asp His Pro Phe Pro Ile Asp Ile Asp Tyr Met Ile 
                965                 970                 975     


Ser Asp Thr Leu Glu Leu Leu Arg Pro Lys Ile Lys Leu Cys Asn Ser 
            980                 985                 990         


Leu Glu Glu Ser Ile Arg Gln Val  Gln Asp Leu Glu Arg  Glu Phe Leu 
        995                 1000                 1005             


Ile Lys  Leu Gly Leu Val Asn  Asp Lys Asp Ser Lys  Asp Ser Met 
    1010                 1015                 1020             


Thr Glu  Gly Glu Asn Leu Glu  Glu Asp Glu Glu Glu  Glu Glu Gly 
    1025                 1030                 1035             


Gly Ala  Glu Thr Glu Glu Gln  Ser Gly Asn Glu Ser  Glu Val Asn 
    1040                 1045                 1050             


Glu Pro  Glu Glu Glu Glu Gly  Ser Asp Asn Asp Asp  Asp Glu Gly 
    1055                 1060                 1065             


Glu Glu  Glu Glu Glu Glu Asn  Thr Asp Tyr Leu Thr  Asp Ser Asn 
    1070                 1075                 1080             


Lys Glu  Asn Glu Thr Asp Glu  Glu Asn Thr Glu Val  Met Ile Lys 
    1085                 1090                 1095             


Gly Gly  Gly Leu Lys His Val  Pro Cys Val Glu Asp  Glu Asp Phe 
    1100                 1105                 1110             


Ile Gln  Ala Leu Asp Lys Met  Met Leu Glu Asn Leu  Gln Gln Arg 
    1115                 1120                 1125             


Ser Gly  Glu Ser Val Lys Val  His Gln Leu Asp Val  Ala Ile Pro 
    1130                 1135                 1140             


Leu His  Leu Lys Ser Gln Leu  Arg Lys Gly Pro Pro  Leu Gly Gly 
    1145                 1150                 1155             


Gly Glu  Gly Glu Ala Glu Ser  Ala Asp Thr Met Pro  Phe Val Met 
    1160                 1165                 1170             


Leu Thr  Arg Lys Gly Asn Lys  Gln Gln Phe Lys Ile  Leu Asn Val 
    1175                 1180                 1185             


Pro Met  Ser Ser Gln Leu Ala  Ala Asn His Trp Asn  Gln Gln Gln 
    1190                 1195                 1200             


Ala Glu  Gln Glu Glu Arg Met  Arg Met Lys Lys Leu  Thr Leu Asp 
    1205                 1210                 1215             


Ile Asn  Glu Arg Gln Glu Gln  Glu Asp Tyr Gln Glu  Met Leu Gln 
    1220                 1225                 1230             


Ser Leu  Ala Gln Arg Pro Ala  Pro Ala Asn Thr Asn  Arg Glu Arg 
    1235                 1240                 1245             


Arg Pro  Arg Tyr Gln His Pro  Lys Gly Ala Pro Asn  Ala Asp Leu 
    1250                 1255                 1260             


Ile Phe  Lys Thr Gly Gly Arg  Arg Arg 
    1265                 1270         


<210> 5
<211> 1359
<212> DNA
<213> Homo sapiens

<400> 5
atgctgtcgg ccctagaagt gcagttccac cgcgactcgc agcagcagga ggctgagacg       60

ccgccaactt cgtcctccgg ttgcgggggc ggtgcgggca aacctcgcga ggagaagagg      120

acggccctga gcaaggtggt catccgccgc ctgcctccgg gcctcaccaa ggagcagctg      180

gaggagcagc tgcgcccgct gccagcacac gactacttcg agttcttcgc cgccgacctg      240

agtctttatc ctcatctcta ctcaagagca tacattaatt ttaggaatcc tgatgacatc      300

cttcttttta gagatcgttt tgatggatat atcttccttg acagcaaagg cctagaatat      360

cctgcagtgg tagagtttgc tccattccag aagatagcca aaaagaagct gagaaaaaaa      420

gatgccaaga ctggaagcat cgaagatgat ccagaatata agaagttttt agaaacctac      480

tgtgtggagg aagagaagac cagtgccaac cctgagactc tgctggggga gatggaggcg      540

aagacaagag agctcattgc tagaagaacc acacctcttt tggaatatat taaaaataga      600

aaattagaaa agcagagaat tcgagaagag aagcgagaag aacggaggag gagagagtta      660

gaaaagaaac gtttgcggga agaggaaaaa agaagaagaa gagaagaaga aagatgcaaa      720

aaaaaagaga cagataaaca gaagaaaatt gcagagaaag aagtaaggat taagcttctt      780

aagaaaccag aaaagggaga ggaaccaacc acagagaaac caaaagaaag aggagaggag      840

attgatactg gaggtggcaa gcaggaatcc tgtgcccccg gtgcagtcgt aaaagccagg      900

cccatggaag gctcgctgga ggagccccag gagacgtcac acagcggcag tgataaagag      960

cacagggatg tggagagatc tcaagaacaa gaatctgaag cacaaagata ccatgtggat     1020

gacggcagga ggcacagagc tcaccacgag cctgaacggc tttccagaag gagtgaggat     1080

gagcagagat gggggaaagg acctggccaa gacagaggga agaaggggag ccaggacagc     1140

ggggctccgg gggaggccat ggagagactg ggaagagcgc aaaggtgtga cgacagtcca     1200

gcacccagaa aagagcgact ggcaaacaag gaccggccag ccttgcagct gtatgatcca     1260

ggagctcgct tccgagcgcg agagtgtggc ggaaacagga ggatctgcaa ggcagaaggt     1320

tcggggactg gtcctgagaa gagggaagag gcagagtga                            1359


<210> 6
<211> 452
<212> PRT
<213> Homo sapiens

<400> 6
Met Leu Ser Ala Leu Glu Val Gln Phe His Arg Asp Ser Gln Gln Gln 
1               5                   10                  15      


Glu Ala Glu Thr Pro Pro Thr Ser Ser Ser Gly Cys Gly Gly Gly Ala 
            20                  25                  30          


Gly Lys Pro Arg Glu Glu Lys Arg Thr Ala Leu Ser Lys Val Val Ile 
        35                  40                  45              


Arg Arg Leu Pro Pro Gly Leu Thr Lys Glu Gln Leu Glu Glu Gln Leu 
    50                  55                  60                  


Arg Pro Leu Pro Ala His Asp Tyr Phe Glu Phe Phe Ala Ala Asp Leu 
65                  70                  75                  80  


Ser Leu Tyr Pro His Leu Tyr Ser Arg Ala Tyr Ile Asn Phe Arg Asn 
                85                  90                  95      


Pro Asp Asp Ile Leu Leu Phe Arg Asp Arg Phe Asp Gly Tyr Ile Phe 
            100                 105                 110         


Leu Asp Ser Lys Gly Leu Glu Tyr Pro Ala Val Val Glu Phe Ala Pro 
        115                 120                 125             


Phe Gln Lys Ile Ala Lys Lys Lys Leu Arg Lys Lys Asp Ala Lys Thr 
    130                 135                 140                 


Gly Ser Ile Glu Asp Asp Pro Glu Tyr Lys Lys Phe Leu Glu Thr Tyr 
145                 150                 155                 160 


Cys Val Glu Glu Glu Lys Thr Ser Ala Asn Pro Glu Thr Leu Leu Gly 
                165                 170                 175     


Glu Met Glu Ala Lys Thr Arg Glu Leu Ile Ala Arg Arg Thr Thr Pro 
            180                 185                 190         


Leu Leu Glu Tyr Ile Lys Asn Arg Lys Leu Glu Lys Gln Arg Ile Arg 
        195                 200                 205             


Glu Glu Lys Arg Glu Glu Arg Arg Arg Arg Glu Leu Glu Lys Lys Arg 
    210                 215                 220                 


Leu Arg Glu Glu Glu Lys Arg Arg Arg Arg Glu Glu Glu Arg Cys Lys 
225                 230                 235                 240 


Lys Lys Glu Thr Asp Lys Gln Lys Lys Ile Ala Glu Lys Glu Val Arg 
                245                 250                 255     


Ile Lys Leu Leu Lys Lys Pro Glu Lys Gly Glu Glu Pro Thr Thr Glu 
            260                 265                 270         


Lys Pro Lys Glu Arg Gly Glu Glu Ile Asp Thr Gly Gly Gly Lys Gln 
        275                 280                 285             


Glu Ser Cys Ala Pro Gly Ala Val Val Lys Ala Arg Pro Met Glu Gly 
    290                 295                 300                 


Ser Leu Glu Glu Pro Gln Glu Thr Ser His Ser Gly Ser Asp Lys Glu 
305                 310                 315                 320 


His Arg Asp Val Glu Arg Ser Gln Glu Gln Glu Ser Glu Ala Gln Arg 
                325                 330                 335     


Tyr His Val Asp Asp Gly Arg Arg His Arg Ala His His Glu Pro Glu 
            340                 345                 350         


Arg Leu Ser Arg Arg Ser Glu Asp Glu Gln Arg Trp Gly Lys Gly Pro 
        355                 360                 365             


Gly Gln Asp Arg Gly Lys Lys Gly Ser Gln Asp Ser Gly Ala Pro Gly 
    370                 375                 380                 


Glu Ala Met Glu Arg Leu Gly Arg Ala Gln Arg Cys Asp Asp Ser Pro 
385                 390                 395                 400 


Ala Pro Arg Lys Glu Arg Leu Ala Asn Lys Asp Arg Pro Ala Leu Gln 
                405                 410                 415     


Leu Tyr Asp Pro Gly Ala Arg Phe Arg Ala Arg Glu Cys Gly Gly Asn 
            420                 425                 430         


Arg Arg Ile Cys Lys Ala Glu Gly Ser Gly Thr Gly Pro Glu Lys Arg 
        435                 440                 445             


Glu Glu Ala Glu 
    450         


<210> 7
<211> 10986
<212> DNA
<213> Homo sapiens

<400> 7
atgagccgca gagccccggg gtctcggctg agcagcggcg gcggcggcgg cggcaccaag       60

tatccgcgga gctggaatga ctggcaaccc agaactgata gtgcatcagc cgacccagat      120

aatttaaaat attcttcatc cagagataga ggtggttctt cctcttatgg actgcaacct      180

tcaaattcag ctgtggtgtc tcggcaaagg cacgatgata ccagagtcca cgctgacata      240

cagaatgacg aaaagggtgg ctacagtgtc aatggaggat ctggggaaaa tacttatggt      300

cggaagtcgt tggggcaaga gctgagggtt aacaatgtga ccagccctga gttcaccagt      360

gttcagcatg gcagtcgtgc tttagccacc aaagacatga ggaaatcaca ggagagatcg      420

atgtcttatt ctgatgagtc tcgactgtcg aatcttcttc ggaggatcac ccgggaagac      480

gacagagacc gaagattggc tactgtaaag cagttgaaag aatttattca gcaaccagaa      540

aataagctgg tactagttaa acaattggat aatatcttgg ctgctgtaca tgacgtgctt      600

aatgaaagta gcaaattgct tcaggagttg agacaggagg gagcttgctg tcttggcctt      660

ctttgtgctt ctctgagcta tgaggctgag aagatcttca agtggatttt tagcaaattt      720

agctcatctg caaaagatga agttaaactc ctctacttat gtgccaccta caaagcacta      780

gagactgtag gagaaaagaa agccttttca tctgtaatgc agcttgtaat gaccagcctg      840

cagtctattc ttgaaaatgt ggatacacca gaattgcttt gtaaatgtgt taagtgcatt      900

cttttggtgg ctcgatgtta ccctcatatt ttcagcacta attttaggga tacagttgat      960

atattagttg gatggcatat agatcatact cagaaacctt cgctcacgca gcaggtatct     1020

gggtggttgc agagtttgga gccattttgg gtagctgatc ttgcattttc tactactctt     1080

cttggtcagt ttctggaaga catggaagca tatgctgagg acctcagcca tgtggcctct     1140

ggggaatcag tggatgaaga tgtccctcct ccatcagtgt cattaccaaa gctggctgca     1200

cttctccggg tatttagtac tgtggtgagg agcattgggg aacgcttcag cccaattcgg     1260

ggtcctccaa ttactgaggc atatgtaaca gatgttctgt acagagtaat gagatgtgtg     1320

acggctgcaa accaggtgtt tttttctgag gctgtgttga cagctgctaa tgagtgtgtt     1380

ggtgttttgc tcggcagctt ggatcctagc atgactatac attgtgacat ggtcattaca     1440

tatggattag accaactgga gaattgccag acttgtggta ccgattatat catctcagtc     1500

ttgaatttac tcacgctgat tgttgaacag ataaatacga aactgccatc atcatttgta     1560

gaaaaactgt ttataccatc atctaaacta ctattcttgc gttatcataa agaaaaagag     1620

gttgttgctg tagcccatgc tgtttatcaa gcagtgctca gcttgaagaa tattcctgtt     1680

ttggagactg cctataagtt aatattggga gaaatgactt gtgccctaaa caacctccta     1740

cacagtctac aacttcctga ggcctgttct gaaataaaac atgaggcttt taagaatcat     1800

gtgttcaatg tagacaatgc aaaatttgta gttatatttg acctcagtgc cctgactaca     1860

attggaaatg ccaaaaactc actaataggg atgtgggcgc tatctccaac tgtctttgca     1920

cttctgagta agaatctgat gattgtgcac agtgacctgg ctgttcactt ccctgccatt     1980

cagtatgctg tgctctacac attgtattct cattgtacca ggcatgatca ctttatctct     2040

agtagcctca gttcttcctc tccttctttg tttgatggag ctgtgattag cactgtaact     2100

acggctacaa agaaacattt ctcaattata ttaaatcttc tgggaatatt acttaagaaa     2160

gataacctta accaggacac gaggaaactg ttaatgactt gggctttgga agcagctgtt     2220

ttaatgaaga agtctgaaac atacgcacct ttattctctc ttccgtcttt ccataaattt     2280

tgcaaaggcc ttttagccaa cactctcgtt gaagatgtga atatctgtct gcaggcatgc     2340

agcagtctac atgctctgtc ctcttccttg ccagatgatc ttttacagag atgtgtcgat     2400

gtttgccgtg ttcaactagt gcacagtgga actcgtattc gacaagcatt tggaaaactg     2460

ttgaaatcaa ttcctttaga tgttgtccta agcaataaca atcacacaga aattcaagaa     2520

atttctttag cattaagaag tcacatgagt aaagcaccaa gtaatacatt ccacccccaa     2580

gatttctctg atgttattag ttttattttg tatgggaact ctcatagaac agggaaggac     2640

aattggttgg aaagactgtt ctatagctgc cagagactgg ataagcgtga ccagtcaaca     2700

attccacgca atctcctgaa gacagatgct gtcctttggc agtgggccat atgggaagct     2760

gcacaattca ctgttctttc taagctgaga accccactgg gcagagctca agacaccttc     2820

cagacaattg aaggtatcat tcgaagtctc gcagctcaca cattaaaccc tgatcaggat     2880

gttagtcagt ggacaactgc agacaatgat gaaggccatg gtaacaacca acttagactt     2940

gttcttcttc tgcagtatct ggaaaatctg gagaaattaa tgtataatgc atacgaggga     3000

tgtgctaatg cattaacttc acctcccaag gtcattagaa cttttttcta taccaatcgc     3060

caaacttgtc aggactggct aacgcggatt cgactctcca tcatgagggt aggattgttg     3120

gcaggccagc ctgcagtgac agtgagacat ggctttgact tgcttacaga gatgaaaaca     3180

accagcctat ctcaggggaa tgaattggaa gtaaccatta tgatggtggt agaagcatta     3240

tgtgaacttc attgtcctga agctatacag ggaattgctg tctggtcatc atctattgtt     3300

ggaaaaaatc ttctgtggat taactcagtg gctcaacagg ctgaagggag gtttgaaaag     3360

gcctctgtgg agtaccagga acacctgtgt gccatgacag gtgttgattg ctgcatctcc     3420

agctttgaca aatcggtgct caccttagcc aatgctgggc gtaacagtgc cagcccgaaa     3480

cattctctga atggtgaatc cagaaaaact gtgctgtcca aaccgactga ctcttcccct     3540

gaggttataa attatttagg aaataaagca tgtgagtgct acatctcaat tgccgattgg     3600

gctgctgtgc aggaatggca gaacgctatc catgacttga aaaagagtac cagtagcact     3660

tccctcaacc tgaaagctga cttcaactat ataaaatcat taagcagctt tgagtctgga     3720

aaatttgttg aatgtaccga gcagttagaa ttgttaccag gagaaaatat caatctactt     3780

gctggaggat caaaagaaaa aatagacatg aaaaaactgc ttcctaacat gttaagtccg     3840

gatccgaggg aacttcagaa atccattgaa gttcaattgt taagaagttc tgtttgtttg     3900

gcaactgctt taaacccgat agaacaagat cagaagtggc agtctataac tgaaaatgtg     3960

gtaaagtact tgaagcaaac atcccgcatc gctattggac ctctgagact ttctacttta     4020

acagtttcac agtctttgcc agttctaagt accttgcagc tgtattgctc atctgctttg     4080

gagaacacag tttctaacag actttcaaca gaggactgtc ttattccact cttcagtgaa     4140

gctttacgtt catgtaaaca gcatgacgtg aggccatgga tgcaggcatt aaggtatact     4200

atgtaccaga atcagttgtt ggagaaaatt aaagaacaaa cagtcccaat tagaagccat     4260

ctcatggaat taggtctaac agcagcaaaa tttgctagaa aacgagggaa tgtgtccctt     4320

gcaacaagac tgctggcaca gtgcagtgaa gttcagctgg gaaagaccac cactgcacag     4380

gatttagtcc aacattttaa aaaactatca acccaaggtc aagtggatga aaaatggggg     4440

cccgaacttg atattgaaaa aaccaaattg ctttatacag caggccagtc aacacatgca     4500

atggaaatgt tgagttcttg tgccatatct ttctgcaagt ctgtgaaagc tgaatatgca     4560

gttgctaaat caattctgac actggctaaa tggatccagg cagaatggaa agagatttca     4620

ggacagctga aacaggttta cagagctcag caccaacaga acttcacagg tctttctact     4680

ttgtctaaaa acatactcac tctaatagaa ctgccatctg ttaatacgat ggaagaagag     4740

tatcctcgga tcgagagtga atctacagtg catattggag ttggagaacc tgacttcatt     4800

ttgggacagt tgtatcacct gtcttcagta caggcacctg aagtagccaa atcttgggca     4860

gcgttggcca gctgggctta taggtggggc agaaaggtgg ttgacaatgc cagtcaggga     4920

gaaggtgttc gtctgctgcc tagagaaaaa tctgaagttc agaatctact tccagacact     4980

ataactgagg aagagaaaga gagaatatat ggtattcttg gacaggctgt gtgtcggccg     5040

gcggggattc aggatgaaga tataacactt cagataactg agagtgaaga caacgaagaa     5100

gatgacatgg ttgatgttat ctggcgtcag ttgatatcaa gctgcccatg gctttcagaa     5160

cttgatgaaa gtgcaactga aggagttatt aaagtgtgga ggaaagttgt agatagaata     5220

ttcagcctgt acaaactctc ttgcagtgca tactttactt tccttaaact caacgctggt     5280

caaattcctt tagatgagga tgaccctagg ctgcatttaa gtcacagagt ggaacagagc     5340

actgatgaca tgattgtgat ggccacattg cgcctgctgc ggttgctcgt gaagcatgct     5400

ggtgagcttc ggcagtatct ggagcacggc ttggagacaa cacccactgc accatggaga     5460

ggaattattc cgcaactttt ctcacgctta aaccaccctg aagtgtatgt gcgccaaagt     5520

atttgtaacc ttctctgccg tgtggctcaa gattccccac atctcatatt gtatcctgca     5580

atagtgggta ccatatcgct tagtagtgaa tcccaggctt caggaaataa attttccact     5640

gcaattccaa ctttacttgg caatattcaa ggagaagaat tgctggtttc tgaatgtgag     5700

ggaggaagtc ctcctgcatc tcaggatagc aataaggatg aacctaaaag tggattaaat     5760

gaagaccaag ccatgatgca ggattgttac agcaaaattg tagataagct gtcctctgca     5820

aaccccacca tggtattaca ggttcagatg ctcgtggctg aactgcgcag ggtcactgtg     5880

ctctgggatg agctctggct gggagttttg ctgcaacaac acatgtatgt cctgagacga     5940

attcagcagc ttgaagatga ggtgaagaga gtccagaaca acaacacctt acgcaaagaa     6000

gagaaaattg caatcatgag ggagaagcac acagctttga tgaagcccat cgtatttgct     6060

ttggagcatg tgaggagtat cacagcggct cctgcagaaa cacctcatga aaaatggttt     6120

caggataact atggtgatgc cattgaaaat gccctagaaa aactgaagac tccattgaac     6180

cctgcaaagc ctgggagcag ctggattcca tttaaagaga taatgctaag tttgcaacag     6240

agagcacaga aacgtgcaag ttacatcttg cgtcttgaag aaatcagtcc atggttggct     6300

gccatgacta acactgaaat tgctcttcct ggggaagtct cagccagaga cactgtcaca     6360

atccatagtg tgggcggaac catcacaatc ttaccgacta aaaccaagcc aaagaaactt     6420

ctctttcttg gatcagatgg gaagagctat ccttatcttt tcaaaggact ggaggattta     6480

catctggatg agagaataat gcagttccta tctattgtga ataccatgtt tgctacaatt     6540

aatcgccaag aaacaccccg gttccatgct cgacactatt ctgtaacacc actaggaaca     6600

agatcaggac taatccagtg ggtagatgga gccacaccct tatttggtct ttacaaacga     6660

tggcaacaac gggaagctgc cttacaagca caaaaggccc aagattccta ccaaactcct     6720

cagaatcctg gaattgtacc ccgtcctagt gaactttatt acagtaaaat tggccctgct     6780

ttgaaaacag ttgggcttag cctggatgtg tcccgtcggg attggcctct tcatgtaatg     6840

aaggcagtat tggaagagtt aatggaggcc acacccccga atctccttgc caaagagctc     6900

tggtcatctt gcacaacacc tgatgaatgg tggagagtta cgcagtctta tgcaagatct     6960

actgcagtca tgtctatggt tggatacata attggccttg gagacagaca tctggataat     7020

gttcttatag atatgacgac tggagaagtt gttcacatag attacaatgt ttgctttgaa     7080

aaaggtaaaa gccttagagt tcctgagaaa gtaccttttc gaatgacaca aaacattgaa     7140

acagcactgg gtgtaactgg agtagaaggt gtatttaggc tttcatgtga gcaggtttta     7200

cacattatgc ggcgtggcag agagaccctg ctgacgctgc tggaggcctt tgtgtacgac     7260

cctctggtgg actggacagc aggaggcgag gctgggtttg ctggtgctgt ctatggtgga     7320

ggtggccagc aggccgagag caagcagagc aagagagaga tggagcgaga gatcacccgc     7380

agcctgtttt cttctagagt agctgagatt aaggtgaact ggtttaagaa tagagatgag     7440

atgctggttg tgcttcccaa gttggacggt agcttagatg aatacctaag cttgcaagag     7500

caactgacag atgtggaaaa actgcagggc aaactactgg aggaaataga gtttctagaa     7560

ggagctgaag gggtggatca tccttctcat actctgcaac acaggtattc tgagcacacc     7620

caactacaga ctcagcaaag agctgttcag gaagcaatcc aggtgaagct gaatgaattt     7680

gaacaatgga taacacatta tcaggctgca ttcaataatt tagaagcaac acagcttgca     7740

agcttgcttc aagagataag cacacaaatg gaccttggtc ctccaagtta cgtgccagca     7800

acagcctttc tgcagaatgc tggtcaggcc cacttgatta gccagtgcga gcagctggag     7860

ggggaggttg gtgctctcct gcagcagagg cgctccgtgc tccgtggctg tctggagcaa     7920

ctgcatcact atgcaaccgt ggccctgcag tatccgaagg ccatatttca gaaacatcga     7980

attgaacagt ggaagacctg gatggaagag ctcatctgta acaccacagt agagcgttgt     8040

caagagctct ataggaaata tgaaatgcaa tatgctcccc agccaccccc aacagtgtgt     8100

cagttcatca ctgccactga aatgaccctg cagcgatacg cagcagacat caacagcaga     8160

cttattagac aagtggaacg cttgaaacag gaagctgtca ctgtgccagt ttgtgaagat     8220

cagttgaaag aaattgaacg ttgcattaaa gttttccttc atgagaatgg agaagaagga     8280

tctttgagtc tagcaagtgt tattatttct gccctttgta cccttacaag gcgtaacctg     8340

atgatggaag gtgcagcgtc aagtgctgga gaacagctgg ttgatctgac ttctcgggat     8400

ggagcctggt tcttggagga actctgcagt atgagcggaa acgtcacctg cttggttcag     8460

ttactgaagc agtgccacct ggtgccacag gacttagata tcccgaaccc catggaagcg     8520

tctgagacag ttcacttagc caatggagtg tatacctcac ttcaggaatt gaattcgaat     8580

ttccggcaaa tcatatttcc agaagcactt cgatgtttaa tgaaagggga atacacgtta     8640

gaaagtatgc tgcatgaact ggacggtctt attgagcaga ccaccgatgg cgttcccctg     8700

cagactctag tggaatctct tcaggcctac ttaagaaacg cagctatggg actggaagaa     8760

gaaacacatg ctcattacat cgatgttgcc agactactac atgctcagta cggtgaatta     8820

atccaaccga gaaatggttc agttgatgaa acacccaaaa tgtcagctgg ccagatgctt     8880

ttggtagcat tcgatggcat gtttgctcaa gttgaaactg ctttcagctt attagttgaa     8940

aagttgaaca agatggaaat tcccatagct tggcgaaaga ttgacatcat aagggaagcc     9000

aggagtactc aagttaattt ttttgatgat gataatcacc ggcaggtgct agaagagatt     9060

ttctttctaa aaagactaca gactattaag gagttcttca ggctctgtgg taccttttct     9120

aaaacattgt caggatcaag ttcacttgaa gatcagaata ctgtgaatgg gcctgtacag     9180

attgtcaatg tgaaaaccct ttttagaaac tcttgtttca gtgaagacca aatggccaaa     9240

cctatcaagg cattcacagc tgactttgtg aggcagctct tgatagggct acccaaccaa     9300

gccctcggac tcacactgtg cagttttatc agtgctctgg gtgtagacat cattgctcaa     9360

gtagaggcaa aggactttgg tgccgaaagc aaagtttctg ttgatgatct ctgtaagaaa     9420

gcggtggaac ataacatcca gatagggaag ttctctcagc tggttatgaa cagggcaact     9480

gtgttagcaa gttcttacga cactgcctgg aagaagcatg acttggtgcg aaggctagaa     9540

accagtattt cttcttgtaa gacaagcctg cagcgggttc agctgcatat tgccatgttt     9600

cagtggcaac atgaagatct acttatcaat agaccacaag ccatgtcagt cacacctccc     9660

ccacggtctg ctatcctaac cagcatgaaa aagaagctgc ataccctgag ccagattgaa     9720

acttctattg caacagttca ggagaagcta gctgcacttg aatcaagtat tgaacagcga     9780

ctcaagtggg caggtggtgc caaccctgca ttggcccctg tactacaaga ttttgaagca     9840

acgatagctg aaagaagaaa tcttgtcctt aaagagagcc aaagagcaag tcaggtcaca     9900

tttctctgca gcaatatcat tcattttgaa agtttacgaa caagaactgc agaagcctta     9960

aacctggatg cggcgttatt tgaactaatc aagcgatgtc agcagatgtg ttcgtttgca    10020

tcacagttta acagttcagt gtctgagtta gagcttcgtt tattacagag agtggacact    10080

ggtcttgaac atcctattgg cagctctgaa tggcttttgt cagcacacaa acagttgacc    10140

caggatatgt ctactcagag ggcaattcag acagagaaag agcagcagat agaaacggtc    10200

tgtgaaacaa ttcagaatct ggttgataat ataaagactg tgctcactgg tcataaccga    10260

cagcttggag atgtcaaaca tctcttgaaa gctatggcta aggatgaaga agctgctctg    10320

gcagatggtg aagatgttcc ctatgagaac agtgttaggc agtttttggg tgaatataaa    10380

tcatggcaag acaacattca aacagttcta tttacattag tccaggctat gggtcaggtt    10440

cgaagtcaag aacacgttga aatgctccag gaaatcactc ccaccttgaa agaactgaaa    10500

acacaaagtc agagtatcta taataattta gtgagttttg catcaccctt agtcaccgat    10560

gcaacaaatg aatgttcgag tccaacgtca tctgctactt atcagccatc cttcgctgca    10620

gcagtccgga gtaacactgg ccagaagact cagcctgatg tcatgtcaca gaatgctaga    10680

aagctgatcc agaaaaatct tgctacatca gctgatactc caccaagcac cgttccagga    10740

actggcaaga gtgttgcttg tagtcctaaa aaggcagtca gagaccctaa aactgggaaa    10800

gcggtgcaag agagaaactc ctatgcagtg agtgtgtgga agagagtgaa agccaagtta    10860

gagggccgag atgttgatcc gaataggagg atgtcagttg ctgaacaggt tgactatgtc    10920

attaaggaag caactaatct agataacttg gctcagctgt atgaaggttg gacagcctgg    10980

gtgtga                                                               10986


<210> 8
<211> 3661
<212> PRT
<213> Homo sapiens

<400> 8
Met Ser Arg Arg Ala Pro Gly Ser Arg Leu Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Thr Lys Tyr Pro Arg Ser Trp Asn Asp Trp Gln Pro Arg Thr 
            20                  25                  30          


Asp Ser Ala Ser Ala Asp Pro Asp Asn Leu Lys Tyr Ser Ser Ser Arg 
        35                  40                  45              


Asp Arg Gly Gly Ser Ser Ser Tyr Gly Leu Gln Pro Ser Asn Ser Ala 
    50                  55                  60                  


Val Val Ser Arg Gln Arg His Asp Asp Thr Arg Val His Ala Asp Ile 
65                  70                  75                  80  


Gln Asn Asp Glu Lys Gly Gly Tyr Ser Val Asn Gly Gly Ser Gly Glu 
                85                  90                  95      


Asn Thr Tyr Gly Arg Lys Ser Leu Gly Gln Glu Leu Arg Val Asn Asn 
            100                 105                 110         


Val Thr Ser Pro Glu Phe Thr Ser Val Gln His Gly Ser Arg Ala Leu 
        115                 120                 125             


Ala Thr Lys Asp Met Arg Lys Ser Gln Glu Arg Ser Met Ser Tyr Ser 
    130                 135                 140                 


Asp Glu Ser Arg Leu Ser Asn Leu Leu Arg Arg Ile Thr Arg Glu Asp 
145                 150                 155                 160 


Asp Arg Asp Arg Arg Leu Ala Thr Val Lys Gln Leu Lys Glu Phe Ile 
                165                 170                 175     


Gln Gln Pro Glu Asn Lys Leu Val Leu Val Lys Gln Leu Asp Asn Ile 
            180                 185                 190         


Leu Ala Ala Val His Asp Val Leu Asn Glu Ser Ser Lys Leu Leu Gln 
        195                 200                 205             


Glu Leu Arg Gln Glu Gly Ala Cys Cys Leu Gly Leu Leu Cys Ala Ser 
    210                 215                 220                 


Leu Ser Tyr Glu Ala Glu Lys Ile Phe Lys Trp Ile Phe Ser Lys Phe 
225                 230                 235                 240 


Ser Ser Ser Ala Lys Asp Glu Val Lys Leu Leu Tyr Leu Cys Ala Thr 
                245                 250                 255     


Tyr Lys Ala Leu Glu Thr Val Gly Glu Lys Lys Ala Phe Ser Ser Val 
            260                 265                 270         


Met Gln Leu Val Met Thr Ser Leu Gln Ser Ile Leu Glu Asn Val Asp 
        275                 280                 285             


Thr Pro Glu Leu Leu Cys Lys Cys Val Lys Cys Ile Leu Leu Val Ala 
    290                 295                 300                 


Arg Cys Tyr Pro His Ile Phe Ser Thr Asn Phe Arg Asp Thr Val Asp 
305                 310                 315                 320 


Ile Leu Val Gly Trp His Ile Asp His Thr Gln Lys Pro Ser Leu Thr 
                325                 330                 335     


Gln Gln Val Ser Gly Trp Leu Gln Ser Leu Glu Pro Phe Trp Val Ala 
            340                 345                 350         


Asp Leu Ala Phe Ser Thr Thr Leu Leu Gly Gln Phe Leu Glu Asp Met 
        355                 360                 365             


Glu Ala Tyr Ala Glu Asp Leu Ser His Val Ala Ser Gly Glu Ser Val 
    370                 375                 380                 


Asp Glu Asp Val Pro Pro Pro Ser Val Ser Leu Pro Lys Leu Ala Ala 
385                 390                 395                 400 


Leu Leu Arg Val Phe Ser Thr Val Val Arg Ser Ile Gly Glu Arg Phe 
                405                 410                 415     


Ser Pro Ile Arg Gly Pro Pro Ile Thr Glu Ala Tyr Val Thr Asp Val 
            420                 425                 430         


Leu Tyr Arg Val Met Arg Cys Val Thr Ala Ala Asn Gln Val Phe Phe 
        435                 440                 445             


Ser Glu Ala Val Leu Thr Ala Ala Asn Glu Cys Val Gly Val Leu Leu 
    450                 455                 460                 


Gly Ser Leu Asp Pro Ser Met Thr Ile His Cys Asp Met Val Ile Thr 
465                 470                 475                 480 


Tyr Gly Leu Asp Gln Leu Glu Asn Cys Gln Thr Cys Gly Thr Asp Tyr 
                485                 490                 495     


Ile Ile Ser Val Leu Asn Leu Leu Thr Leu Ile Val Glu Gln Ile Asn 
            500                 505                 510         


Thr Lys Leu Pro Ser Ser Phe Val Glu Lys Leu Phe Ile Pro Ser Ser 
        515                 520                 525             


Lys Leu Leu Phe Leu Arg Tyr His Lys Glu Lys Glu Val Val Ala Val 
    530                 535                 540                 


Ala His Ala Val Tyr Gln Ala Val Leu Ser Leu Lys Asn Ile Pro Val 
545                 550                 555                 560 


Leu Glu Thr Ala Tyr Lys Leu Ile Leu Gly Glu Met Thr Cys Ala Leu 
                565                 570                 575     


Asn Asn Leu Leu His Ser Leu Gln Leu Pro Glu Ala Cys Ser Glu Ile 
            580                 585                 590         


Lys His Glu Ala Phe Lys Asn His Val Phe Asn Val Asp Asn Ala Lys 
        595                 600                 605             


Phe Val Val Ile Phe Asp Leu Ser Ala Leu Thr Thr Ile Gly Asn Ala 
    610                 615                 620                 


Lys Asn Ser Leu Ile Gly Met Trp Ala Leu Ser Pro Thr Val Phe Ala 
625                 630                 635                 640 


Leu Leu Ser Lys Asn Leu Met Ile Val His Ser Asp Leu Ala Val His 
                645                 650                 655     


Phe Pro Ala Ile Gln Tyr Ala Val Leu Tyr Thr Leu Tyr Ser His Cys 
            660                 665                 670         


Thr Arg His Asp His Phe Ile Ser Ser Ser Leu Ser Ser Ser Ser Pro 
        675                 680                 685             


Ser Leu Phe Asp Gly Ala Val Ile Ser Thr Val Thr Thr Ala Thr Lys 
    690                 695                 700                 


Lys His Phe Ser Ile Ile Leu Asn Leu Leu Gly Ile Leu Leu Lys Lys 
705                 710                 715                 720 


Asp Asn Leu Asn Gln Asp Thr Arg Lys Leu Leu Met Thr Trp Ala Leu 
                725                 730                 735     


Glu Ala Ala Val Leu Met Lys Lys Ser Glu Thr Tyr Ala Pro Leu Phe 
            740                 745                 750         


Ser Leu Pro Ser Phe His Lys Phe Cys Lys Gly Leu Leu Ala Asn Thr 
        755                 760                 765             


Leu Val Glu Asp Val Asn Ile Cys Leu Gln Ala Cys Ser Ser Leu His 
    770                 775                 780                 


Ala Leu Ser Ser Ser Leu Pro Asp Asp Leu Leu Gln Arg Cys Val Asp 
785                 790                 795                 800 


Val Cys Arg Val Gln Leu Val His Ser Gly Thr Arg Ile Arg Gln Ala 
                805                 810                 815     


Phe Gly Lys Leu Leu Lys Ser Ile Pro Leu Asp Val Val Leu Ser Asn 
            820                 825                 830         


Asn Asn His Thr Glu Ile Gln Glu Ile Ser Leu Ala Leu Arg Ser His 
        835                 840                 845             


Met Ser Lys Ala Pro Ser Asn Thr Phe His Pro Gln Asp Phe Ser Asp 
    850                 855                 860                 


Val Ile Ser Phe Ile Leu Tyr Gly Asn Ser His Arg Thr Gly Lys Asp 
865                 870                 875                 880 


Asn Trp Leu Glu Arg Leu Phe Tyr Ser Cys Gln Arg Leu Asp Lys Arg 
                885                 890                 895     


Asp Gln Ser Thr Ile Pro Arg Asn Leu Leu Lys Thr Asp Ala Val Leu 
            900                 905                 910         


Trp Gln Trp Ala Ile Trp Glu Ala Ala Gln Phe Thr Val Leu Ser Lys 
        915                 920                 925             


Leu Arg Thr Pro Leu Gly Arg Ala Gln Asp Thr Phe Gln Thr Ile Glu 
    930                 935                 940                 


Gly Ile Ile Arg Ser Leu Ala Ala His Thr Leu Asn Pro Asp Gln Asp 
945                 950                 955                 960 


Val Ser Gln Trp Thr Thr Ala Asp Asn Asp Glu Gly His Gly Asn Asn 
                965                 970                 975     


Gln Leu Arg Leu Val Leu Leu Leu Gln Tyr Leu Glu Asn Leu Glu Lys 
            980                 985                 990         


Leu Met Tyr Asn Ala Tyr Glu Gly  Cys Ala Asn Ala Leu  Thr Ser Pro 
        995                 1000                 1005             


Pro Lys  Val Ile Arg Thr Phe  Phe Tyr Thr Asn Arg  Gln Thr Cys 
    1010                 1015                 1020             


Gln Asp  Trp Leu Thr Arg Ile  Arg Leu Ser Ile Met  Arg Val Gly 
    1025                 1030                 1035             


Leu Leu  Ala Gly Gln Pro Ala  Val Thr Val Arg His  Gly Phe Asp 
    1040                 1045                 1050             


Leu Leu  Thr Glu Met Lys Thr  Thr Ser Leu Ser Gln  Gly Asn Glu 
    1055                 1060                 1065             


Leu Glu  Val Thr Ile Met Met  Val Val Glu Ala Leu  Cys Glu Leu 
    1070                 1075                 1080             


His Cys  Pro Glu Ala Ile Gln  Gly Ile Ala Val Trp  Ser Ser Ser 
    1085                 1090                 1095             


Ile Val  Gly Lys Asn Leu Leu  Trp Ile Asn Ser Val  Ala Gln Gln 
    1100                 1105                 1110             


Ala Glu  Gly Arg Phe Glu Lys  Ala Ser Val Glu Tyr  Gln Glu His 
    1115                 1120                 1125             


Leu Cys  Ala Met Thr Gly Val  Asp Cys Cys Ile Ser  Ser Phe Asp 
    1130                 1135                 1140             


Lys Ser  Val Leu Thr Leu Ala  Asn Ala Gly Arg Asn  Ser Ala Ser 
    1145                 1150                 1155             


Pro Lys  His Ser Leu Asn Gly  Glu Ser Arg Lys Thr  Val Leu Ser 
    1160                 1165                 1170             


Lys Pro  Thr Asp Ser Ser Pro  Glu Val Ile Asn Tyr  Leu Gly Asn 
    1175                 1180                 1185             


Lys Ala  Cys Glu Cys Tyr Ile  Ser Ile Ala Asp Trp  Ala Ala Val 
    1190                 1195                 1200             


Gln Glu  Trp Gln Asn Ala Ile  His Asp Leu Lys Lys  Ser Thr Ser 
    1205                 1210                 1215             


Ser Thr  Ser Leu Asn Leu Lys  Ala Asp Phe Asn Tyr  Ile Lys Ser 
    1220                 1225                 1230             


Leu Ser  Ser Phe Glu Ser Gly  Lys Phe Val Glu Cys  Thr Glu Gln 
    1235                 1240                 1245             


Leu Glu  Leu Leu Pro Gly Glu  Asn Ile Asn Leu Leu  Ala Gly Gly 
    1250                 1255                 1260             


Ser Lys  Glu Lys Ile Asp Met  Lys Lys Leu Leu Pro  Asn Met Leu 
    1265                 1270                 1275             


Ser Pro  Asp Pro Arg Glu Leu  Gln Lys Ser Ile Glu  Val Gln Leu 
    1280                 1285                 1290             


Leu Arg  Ser Ser Val Cys Leu  Ala Thr Ala Leu Asn  Pro Ile Glu 
    1295                 1300                 1305             


Gln Asp  Gln Lys Trp Gln Ser  Ile Thr Glu Asn Val  Val Lys Tyr 
    1310                 1315                 1320             


Leu Lys  Gln Thr Ser Arg Ile  Ala Ile Gly Pro Leu  Arg Leu Ser 
    1325                 1330                 1335             


Thr Leu  Thr Val Ser Gln Ser  Leu Pro Val Leu Ser  Thr Leu Gln 
    1340                 1345                 1350             


Leu Tyr  Cys Ser Ser Ala Leu  Glu Asn Thr Val Ser  Asn Arg Leu 
    1355                 1360                 1365             


Ser Thr  Glu Asp Cys Leu Ile  Pro Leu Phe Ser Glu  Ala Leu Arg 
    1370                 1375                 1380             


Ser Cys  Lys Gln His Asp Val  Arg Pro Trp Met Gln  Ala Leu Arg 
    1385                 1390                 1395             


Tyr Thr  Met Tyr Gln Asn Gln  Leu Leu Glu Lys Ile  Lys Glu Gln 
    1400                 1405                 1410             


Thr Val  Pro Ile Arg Ser His  Leu Met Glu Leu Gly  Leu Thr Ala 
    1415                 1420                 1425             


Ala Lys  Phe Ala Arg Lys Arg  Gly Asn Val Ser Leu  Ala Thr Arg 
    1430                 1435                 1440             


Leu Leu  Ala Gln Cys Ser Glu  Val Gln Leu Gly Lys  Thr Thr Thr 
    1445                 1450                 1455             


Ala Gln  Asp Leu Val Gln His  Phe Lys Lys Leu Ser  Thr Gln Gly 
    1460                 1465                 1470             


Gln Val  Asp Glu Lys Trp Gly  Pro Glu Leu Asp Ile  Glu Lys Thr 
    1475                 1480                 1485             


Lys Leu  Leu Tyr Thr Ala Gly  Gln Ser Thr His Ala  Met Glu Met 
    1490                 1495                 1500             


Leu Ser  Ser Cys Ala Ile Ser  Phe Cys Lys Ser Val  Lys Ala Glu 
    1505                 1510                 1515             


Tyr Ala  Val Ala Lys Ser Ile  Leu Thr Leu Ala Lys  Trp Ile Gln 
    1520                 1525                 1530             


Ala Glu  Trp Lys Glu Ile Ser  Gly Gln Leu Lys Gln  Val Tyr Arg 
    1535                 1540                 1545             


Ala Gln  His Gln Gln Asn Phe  Thr Gly Leu Ser Thr  Leu Ser Lys 
    1550                 1555                 1560             


Asn Ile  Leu Thr Leu Ile Glu  Leu Pro Ser Val Asn  Thr Met Glu 
    1565                 1570                 1575             


Glu Glu  Tyr Pro Arg Ile Glu  Ser Glu Ser Thr Val  His Ile Gly 
    1580                 1585                 1590             


Val Gly  Glu Pro Asp Phe Ile  Leu Gly Gln Leu Tyr  His Leu Ser 
    1595                 1600                 1605             


Ser Val  Gln Ala Pro Glu Val  Ala Lys Ser Trp Ala  Ala Leu Ala 
    1610                 1615                 1620             


Ser Trp  Ala Tyr Arg Trp Gly  Arg Lys Val Val Asp  Asn Ala Ser 
    1625                 1630                 1635             


Gln Gly  Glu Gly Val Arg Leu  Leu Pro Arg Glu Lys  Ser Glu Val 
    1640                 1645                 1650             


Gln Asn  Leu Leu Pro Asp Thr  Ile Thr Glu Glu Glu  Lys Glu Arg 
    1655                 1660                 1665             


Ile Tyr  Gly Ile Leu Gly Gln  Ala Val Cys Arg Pro  Ala Gly Ile 
    1670                 1675                 1680             


Gln Asp  Glu Asp Ile Thr Leu  Gln Ile Thr Glu Ser  Glu Asp Asn 
    1685                 1690                 1695             


Glu Glu  Asp Asp Met Val Asp  Val Ile Trp Arg Gln  Leu Ile Ser 
    1700                 1705                 1710             


Ser Cys  Pro Trp Leu Ser Glu  Leu Asp Glu Ser Ala  Thr Glu Gly 
    1715                 1720                 1725             


Val Ile  Lys Val Trp Arg Lys  Val Val Asp Arg Ile  Phe Ser Leu 
    1730                 1735                 1740             


Tyr Lys  Leu Ser Cys Ser Ala  Tyr Phe Thr Phe Leu  Lys Leu Asn 
    1745                 1750                 1755             


Ala Gly  Gln Ile Pro Leu Asp  Glu Asp Asp Pro Arg  Leu His Leu 
    1760                 1765                 1770             


Ser His  Arg Val Glu Gln Ser  Thr Asp Asp Met Ile  Val Met Ala 
    1775                 1780                 1785             


Thr Leu  Arg Leu Leu Arg Leu  Leu Val Lys His Ala  Gly Glu Leu 
    1790                 1795                 1800             


Arg Gln  Tyr Leu Glu His Gly  Leu Glu Thr Thr Pro  Thr Ala Pro 
    1805                 1810                 1815             


Trp Arg  Gly Ile Ile Pro Gln  Leu Phe Ser Arg Leu  Asn His Pro 
    1820                 1825                 1830             


Glu Val  Tyr Val Arg Gln Ser  Ile Cys Asn Leu Leu  Cys Arg Val 
    1835                 1840                 1845             


Ala Gln  Asp Ser Pro His Leu  Ile Leu Tyr Pro Ala  Ile Val Gly 
    1850                 1855                 1860             


Thr Ile  Ser Leu Ser Ser Glu  Ser Gln Ala Ser Gly  Asn Lys Phe 
    1865                 1870                 1875             


Ser Thr  Ala Ile Pro Thr Leu  Leu Gly Asn Ile Gln  Gly Glu Glu 
    1880                 1885                 1890             


Leu Leu  Val Ser Glu Cys Glu  Gly Gly Ser Pro Pro  Ala Ser Gln 
    1895                 1900                 1905             


Asp Ser  Asn Lys Asp Glu Pro  Lys Ser Gly Leu Asn  Glu Asp Gln 
    1910                 1915                 1920             


Ala Met  Met Gln Asp Cys Tyr  Ser Lys Ile Val Asp  Lys Leu Ser 
    1925                 1930                 1935             


Ser Ala  Asn Pro Thr Met Val  Leu Gln Val Gln Met  Leu Val Ala 
    1940                 1945                 1950             


Glu Leu  Arg Arg Val Thr Val  Leu Trp Asp Glu Leu  Trp Leu Gly 
    1955                 1960                 1965             


Val Leu  Leu Gln Gln His Met  Tyr Val Leu Arg Arg  Ile Gln Gln 
    1970                 1975                 1980             


Leu Glu  Asp Glu Val Lys Arg  Val Gln Asn Asn Asn  Thr Leu Arg 
    1985                 1990                 1995             


Lys Glu  Glu Lys Ile Ala Ile  Met Arg Glu Lys His  Thr Ala Leu 
    2000                 2005                 2010             


Met Lys  Pro Ile Val Phe Ala  Leu Glu His Val Arg  Ser Ile Thr 
    2015                 2020                 2025             


Ala Ala  Pro Ala Glu Thr Pro  His Glu Lys Trp Phe  Gln Asp Asn 
    2030                 2035                 2040             


Tyr Gly  Asp Ala Ile Glu Asn  Ala Leu Glu Lys Leu  Lys Thr Pro 
    2045                 2050                 2055             


Leu Asn  Pro Ala Lys Pro Gly  Ser Ser Trp Ile Pro  Phe Lys Glu 
    2060                 2065                 2070             


Ile Met  Leu Ser Leu Gln Gln  Arg Ala Gln Lys Arg  Ala Ser Tyr 
    2075                 2080                 2085             


Ile Leu  Arg Leu Glu Glu Ile  Ser Pro Trp Leu Ala  Ala Met Thr 
    2090                 2095                 2100             


Asn Thr  Glu Ile Ala Leu Pro  Gly Glu Val Ser Ala  Arg Asp Thr 
    2105                 2110                 2115             


Val Thr  Ile His Ser Val Gly  Gly Thr Ile Thr Ile  Leu Pro Thr 
    2120                 2125                 2130             


Lys Thr  Lys Pro Lys Lys Leu  Leu Phe Leu Gly Ser  Asp Gly Lys 
    2135                 2140                 2145             


Ser Tyr  Pro Tyr Leu Phe Lys  Gly Leu Glu Asp Leu  His Leu Asp 
    2150                 2155                 2160             


Glu Arg  Ile Met Gln Phe Leu  Ser Ile Val Asn Thr  Met Phe Ala 
    2165                 2170                 2175             


Thr Ile  Asn Arg Gln Glu Thr  Pro Arg Phe His Ala  Arg His Tyr 
    2180                 2185                 2190             


Ser Val  Thr Pro Leu Gly Thr  Arg Ser Gly Leu Ile  Gln Trp Val 
    2195                 2200                 2205             


Asp Gly  Ala Thr Pro Leu Phe  Gly Leu Tyr Lys Arg  Trp Gln Gln 
    2210                 2215                 2220             


Arg Glu  Ala Ala Leu Gln Ala  Gln Lys Ala Gln Asp  Ser Tyr Gln 
    2225                 2230                 2235             


Thr Pro  Gln Asn Pro Gly Ile  Val Pro Arg Pro Ser  Glu Leu Tyr 
    2240                 2245                 2250             


Tyr Ser  Lys Ile Gly Pro Ala  Leu Lys Thr Val Gly  Leu Ser Leu 
    2255                 2260                 2265             


Asp Val  Ser Arg Arg Asp Trp  Pro Leu His Val Met  Lys Ala Val 
    2270                 2275                 2280             


Leu Glu  Glu Leu Met Glu Ala  Thr Pro Pro Asn Leu  Leu Ala Lys 
    2285                 2290                 2295             


Glu Leu  Trp Ser Ser Cys Thr  Thr Pro Asp Glu Trp  Trp Arg Val 
    2300                 2305                 2310             


Thr Gln  Ser Tyr Ala Arg Ser  Thr Ala Val Met Ser  Met Val Gly 
    2315                 2320                 2325             


Tyr Ile  Ile Gly Leu Gly Asp  Arg His Leu Asp Asn  Val Leu Ile 
    2330                 2335                 2340             


Asp Met  Thr Thr Gly Glu Val  Val His Ile Asp Tyr  Asn Val Cys 
    2345                 2350                 2355             


Phe Glu  Lys Gly Lys Ser Leu  Arg Val Pro Glu Lys  Val Pro Phe 
    2360                 2365                 2370             


Arg Met  Thr Gln Asn Ile Glu  Thr Ala Leu Gly Val  Thr Gly Val 
    2375                 2380                 2385             


Glu Gly  Val Phe Arg Leu Ser  Cys Glu Gln Val Leu  His Ile Met 
    2390                 2395                 2400             


Arg Arg  Gly Arg Glu Thr Leu  Leu Thr Leu Leu Glu  Ala Phe Val 
    2405                 2410                 2415             


Tyr Asp  Pro Leu Val Asp Trp  Thr Ala Gly Gly Glu  Ala Gly Phe 
    2420                 2425                 2430             


Ala Gly  Ala Val Tyr Gly Gly  Gly Gly Gln Gln Ala  Glu Ser Lys 
    2435                 2440                 2445             


Gln Ser  Lys Arg Glu Met Glu  Arg Glu Ile Thr Arg  Ser Leu Phe 
    2450                 2455                 2460             


Ser Ser  Arg Val Ala Glu Ile  Lys Val Asn Trp Phe  Lys Asn Arg 
    2465                 2470                 2475             


Asp Glu  Met Leu Val Val Leu  Pro Lys Leu Asp Gly  Ser Leu Asp 
    2480                 2485                 2490             


Glu Tyr  Leu Ser Leu Gln Glu  Gln Leu Thr Asp Val  Glu Lys Leu 
    2495                 2500                 2505             


Gln Gly  Lys Leu Leu Glu Glu  Ile Glu Phe Leu Glu  Gly Ala Glu 
    2510                 2515                 2520             


Gly Val  Asp His Pro Ser His  Thr Leu Gln His Arg  Tyr Ser Glu 
    2525                 2530                 2535             


His Thr  Gln Leu Gln Thr Gln  Gln Arg Ala Val Gln  Glu Ala Ile 
    2540                 2545                 2550             


Gln Val  Lys Leu Asn Glu Phe  Glu Gln Trp Ile Thr  His Tyr Gln 
    2555                 2560                 2565             


Ala Ala  Phe Asn Asn Leu Glu  Ala Thr Gln Leu Ala  Ser Leu Leu 
    2570                 2575                 2580             


Gln Glu  Ile Ser Thr Gln Met  Asp Leu Gly Pro Pro  Ser Tyr Val 
    2585                 2590                 2595             


Pro Ala  Thr Ala Phe Leu Gln  Asn Ala Gly Gln Ala  His Leu Ile 
    2600                 2605                 2610             


Ser Gln  Cys Glu Gln Leu Glu  Gly Glu Val Gly Ala  Leu Leu Gln 
    2615                 2620                 2625             


Gln Arg  Arg Ser Val Leu Arg  Gly Cys Leu Glu Gln  Leu His His 
    2630                 2635                 2640             


Tyr Ala  Thr Val Ala Leu Gln  Tyr Pro Lys Ala Ile  Phe Gln Lys 
    2645                 2650                 2655             


His Arg  Ile Glu Gln Trp Lys  Thr Trp Met Glu Glu  Leu Ile Cys 
    2660                 2665                 2670             


Asn Thr  Thr Val Glu Arg Cys  Gln Glu Leu Tyr Arg  Lys Tyr Glu 
    2675                 2680                 2685             


Met Gln  Tyr Ala Pro Gln Pro  Pro Pro Thr Val Cys  Gln Phe Ile 
    2690                 2695                 2700             


Thr Ala  Thr Glu Met Thr Leu  Gln Arg Tyr Ala Ala  Asp Ile Asn 
    2705                 2710                 2715             


Ser Arg  Leu Ile Arg Gln Val  Glu Arg Leu Lys Gln  Glu Ala Val 
    2720                 2725                 2730             


Thr Val  Pro Val Cys Glu Asp  Gln Leu Lys Glu Ile  Glu Arg Cys 
    2735                 2740                 2745             


Ile Lys  Val Phe Leu His Glu  Asn Gly Glu Glu Gly  Ser Leu Ser 
    2750                 2755                 2760             


Leu Ala  Ser Val Ile Ile Ser  Ala Leu Cys Thr Leu  Thr Arg Arg 
    2765                 2770                 2775             


Asn Leu  Met Met Glu Gly Ala  Ala Ser Ser Ala Gly  Glu Gln Leu 
    2780                 2785                 2790             


Val Asp  Leu Thr Ser Arg Asp  Gly Ala Trp Phe Leu  Glu Glu Leu 
    2795                 2800                 2805             


Cys Ser  Met Ser Gly Asn Val  Thr Cys Leu Val Gln  Leu Leu Lys 
    2810                 2815                 2820             


Gln Cys  His Leu Val Pro Gln  Asp Leu Asp Ile Pro  Asn Pro Met 
    2825                 2830                 2835             


Glu Ala  Ser Glu Thr Val His  Leu Ala Asn Gly Val  Tyr Thr Ser 
    2840                 2845                 2850             


Leu Gln  Glu Leu Asn Ser Asn  Phe Arg Gln Ile Ile  Phe Pro Glu 
    2855                 2860                 2865             


Ala Leu  Arg Cys Leu Met Lys  Gly Glu Tyr Thr Leu  Glu Ser Met 
    2870                 2875                 2880             


Leu His  Glu Leu Asp Gly Leu  Ile Glu Gln Thr Thr  Asp Gly Val 
    2885                 2890                 2895             


Pro Leu  Gln Thr Leu Val Glu  Ser Leu Gln Ala Tyr  Leu Arg Asn 
    2900                 2905                 2910             


Ala Ala  Met Gly Leu Glu Glu  Glu Thr His Ala His  Tyr Ile Asp 
    2915                 2920                 2925             


Val Ala  Arg Leu Leu His Ala  Gln Tyr Gly Glu Leu  Ile Gln Pro 
    2930                 2935                 2940             


Arg Asn  Gly Ser Val Asp Glu  Thr Pro Lys Met Ser  Ala Gly Gln 
    2945                 2950                 2955             


Met Leu  Leu Val Ala Phe Asp  Gly Met Phe Ala Gln  Val Glu Thr 
    2960                 2965                 2970             


Ala Phe  Ser Leu Leu Val Glu  Lys Leu Asn Lys Met  Glu Ile Pro 
    2975                 2980                 2985             


Ile Ala  Trp Arg Lys Ile Asp  Ile Ile Arg Glu Ala  Arg Ser Thr 
    2990                 2995                 3000             


Gln Val  Asn Phe Phe Asp Asp  Asp Asn His Arg Gln  Val Leu Glu 
    3005                 3010                 3015             


Glu Ile  Phe Phe Leu Lys Arg  Leu Gln Thr Ile Lys  Glu Phe Phe 
    3020                 3025                 3030             


Arg Leu  Cys Gly Thr Phe Ser  Lys Thr Leu Ser Gly  Ser Ser Ser 
    3035                 3040                 3045             


Leu Glu  Asp Gln Asn Thr Val  Asn Gly Pro Val Gln  Ile Val Asn 
    3050                 3055                 3060             


Val Lys  Thr Leu Phe Arg Asn  Ser Cys Phe Ser Glu  Asp Gln Met 
    3065                 3070                 3075             


Ala Lys  Pro Ile Lys Ala Phe  Thr Ala Asp Phe Val  Arg Gln Leu 
    3080                 3085                 3090             


Leu Ile  Gly Leu Pro Asn Gln  Ala Leu Gly Leu Thr  Leu Cys Ser 
    3095                 3100                 3105             


Phe Ile  Ser Ala Leu Gly Val  Asp Ile Ile Ala Gln  Val Glu Ala 
    3110                 3115                 3120             


Lys Asp  Phe Gly Ala Glu Ser  Lys Val Ser Val Asp  Asp Leu Cys 
    3125                 3130                 3135             


Lys Lys  Ala Val Glu His Asn  Ile Gln Ile Gly Lys  Phe Ser Gln 
    3140                 3145                 3150             


Leu Val  Met Asn Arg Ala Thr  Val Leu Ala Ser Ser  Tyr Asp Thr 
    3155                 3160                 3165             


Ala Trp  Lys Lys His Asp Leu  Val Arg Arg Leu Glu  Thr Ser Ile 
    3170                 3175                 3180             


Ser Ser  Cys Lys Thr Ser Leu  Gln Arg Val Gln Leu  His Ile Ala 
    3185                 3190                 3195             


Met Phe  Gln Trp Gln His Glu  Asp Leu Leu Ile Asn  Arg Pro Gln 
    3200                 3205                 3210             


Ala Met  Ser Val Thr Pro Pro  Pro Arg Ser Ala Ile  Leu Thr Ser 
    3215                 3220                 3225             


Met Lys  Lys Lys Leu His Thr  Leu Ser Gln Ile Glu  Thr Ser Ile 
    3230                 3235                 3240             


Ala Thr  Val Gln Glu Lys Leu  Ala Ala Leu Glu Ser  Ser Ile Glu 
    3245                 3250                 3255             


Gln Arg  Leu Lys Trp Ala Gly  Gly Ala Asn Pro Ala  Leu Ala Pro 
    3260                 3265                 3270             


Val Leu  Gln Asp Phe Glu Ala  Thr Ile Ala Glu Arg  Arg Asn Leu 
    3275                 3280                 3285             


Val Leu  Lys Glu Ser Gln Arg  Ala Ser Gln Val Thr  Phe Leu Cys 
    3290                 3295                 3300             


Ser Asn  Ile Ile His Phe Glu  Ser Leu Arg Thr Arg  Thr Ala Glu 
    3305                 3310                 3315             


Ala Leu  Asn Leu Asp Ala Ala  Leu Phe Glu Leu Ile  Lys Arg Cys 
    3320                 3325                 3330             


Gln Gln  Met Cys Ser Phe Ala  Ser Gln Phe Asn Ser  Ser Val Ser 
    3335                 3340                 3345             


Glu Leu  Glu Leu Arg Leu Leu  Gln Arg Val Asp Thr  Gly Leu Glu 
    3350                 3355                 3360             


His Pro  Ile Gly Ser Ser Glu  Trp Leu Leu Ser Ala  His Lys Gln 
    3365                 3370                 3375             


Leu Thr  Gln Asp Met Ser Thr  Gln Arg Ala Ile Gln  Thr Glu Lys 
    3380                 3385                 3390             


Glu Gln  Gln Ile Glu Thr Val  Cys Glu Thr Ile Gln  Asn Leu Val 
    3395                 3400                 3405             


Asp Asn  Ile Lys Thr Val Leu  Thr Gly His Asn Arg  Gln Leu Gly 
    3410                 3415                 3420             


Asp Val  Lys His Leu Leu Lys  Ala Met Ala Lys Asp  Glu Glu Ala 
    3425                 3430                 3435             


Ala Leu  Ala Asp Gly Glu Asp  Val Pro Tyr Glu Asn  Ser Val Arg 
    3440                 3445                 3450             


Gln Phe  Leu Gly Glu Tyr Lys  Ser Trp Gln Asp Asn  Ile Gln Thr 
    3455                 3460                 3465             


Val Leu  Phe Thr Leu Val Gln  Ala Met Gly Gln Val  Arg Ser Gln 
    3470                 3475                 3480             


Glu His  Val Glu Met Leu Gln  Glu Ile Thr Pro Thr  Leu Lys Glu 
    3485                 3490                 3495             


Leu Lys  Thr Gln Ser Gln Ser  Ile Tyr Asn Asn Leu  Val Ser Phe 
    3500                 3505                 3510             


Ala Ser  Pro Leu Val Thr Asp  Ala Thr Asn Glu Cys  Ser Ser Pro 
    3515                 3520                 3525             


Thr Ser  Ser Ala Thr Tyr Gln  Pro Ser Phe Ala Ala  Ala Val Arg 
    3530                 3535                 3540             


Ser Asn  Thr Gly Gln Lys Thr  Gln Pro Asp Val Met  Ser Gln Asn 
    3545                 3550                 3555             


Ala Arg  Lys Leu Ile Gln Lys  Asn Leu Ala Thr Ser  Ala Asp Thr 
    3560                 3565                 3570             


Pro Pro  Ser Thr Val Pro Gly  Thr Gly Lys Ser Val  Ala Cys Ser 
    3575                 3580                 3585             


Pro Lys  Lys Ala Val Arg Asp  Pro Lys Thr Gly Lys  Ala Val Gln 
    3590                 3595                 3600             


Glu Arg  Asn Ser Tyr Ala Val  Ser Val Trp Lys Arg  Val Lys Ala 
    3605                 3610                 3615             


Lys Leu  Glu Gly Arg Asp Val  Asp Pro Asn Arg Arg  Met Ser Val 
    3620                 3625                 3630             


Ala Glu  Gln Val Asp Tyr Val  Ile Lys Glu Ala Thr  Asn Leu Asp 
    3635                 3640                 3645             


Asn Leu  Ala Gln Leu Tyr Glu  Gly Trp Thr Ala Trp  Val 
    3650                 3655                 3660     


<210> 9
<211> 3051
<212> DNA
<213> Homo sapiens

<400> 9
atgagccaag gcccccccac aggggagagc agcgagcccg aagcaaaagt cctccacact       60

aagcggcttt accgggctgt ggtggaggct gtgcatcgac ttgacctcat cctttgcaac      120

aaaactgctt atcaagaagt attcaaacca gaaaacatta gcctgaggaa caagctgcgt      180

gagctctgcg tcaagcttat gttcctgcac ccagtggact atgggagaaa ggctgaggag      240

ctgctgtgga gaaaggtata ctatgaagtt atccagctta tcaagactaa caaaaagcac      300

atccacagcc ggagcacttt ggaatgtgcc tacaggacgc acctggttgc tggtattggc      360

ttctaccagc atctccttct ctatatccag tcccactacc agctggaact gcagtgctgc      420

atcgactgga cccatgtcac tgaccccctc ataggatgca agaagccagt gtctgcctca      480

gggaaggaga tggattgggc acagatggca tgtcaccgat gtctggtgta tctgggggat      540

ttgtcccgat atcagaatga attagctggc gtagataccg agctgctagc cgagagattt      600

tactaccaag ccctgtcagt agctcctcag attggaatgc ccttcaatca gctgggcacc      660

ctggcaggca gcaagtacta taatgtggaa gccatgtatt gctacctgcg ctgcatccag      720

tcagaagtgt cctttgaggg agcctatggg aacctcaagc ggctgtatga caaggcagcc      780

aaaatgtacc accaactgaa gaagtgtgag actcggaaac tgtctcctgg caaaaagcga      840

tgtaaagaca ttaaaaggtt gctagtgaac tttatgtatc tgcaaagcct cctacagccc      900

aaaagcagct ccgtggactc agagctgacc tcactttgcc agtcagtcct ggaggacttc      960

aacctctgcc tcttctacct gccctcctca cccaacctca gcctggccag tgaggatgag     1020

gaggagtatg agagtggata tgctttcctc ccggaccttc tcatctttca aatggtcatc     1080

atctgcctta tgtgtgtgca cagcttggag agagcaggat ccaagcagta cagtgcagcc     1140

attgccttca ccctggccct cttttcccac ctcgtcaatc atgtcaacat acggctgcag     1200

gctgagctgg aagagggcga gaatcccgtc ccggcattcc agagtgatgg cacagatgaa     1260

ccagagtcca aggaacctgt ggagaaagag gaggagccag atcctgagcc tcctcctgta     1320

acaccccaag tgggtgaggg cagaaagagc cgtaagttct ctcgcctctc ctgtctccgc     1380

cgtcgccgcc acccacccaa agttggtgat gacagtgacc tgagtgaagg ctttgaatcg     1440

gactcaagcc atgactcagc ccgggccagt gagggctcag acagtggctc tgacaagagt     1500

cttgaaggtg ggggaacggc ctttgatgct gaaacagact cggaaatgaa tagccaggag     1560

tcccgatcag acttggaaga tatggaggaa gaggagggga cacggtcacc aaccctggag     1620

ccccctcggg gcagatcaga ggctcccgat tccctcaatg gcccactggg ccccagtgag     1680

gctagcattg ccagcaatct acaagccatg tccacccaga tgttccagac taagcgctgc     1740

ttccgactgg cccccacctt tagcaacctg ctcctccagc ccaccaccaa ccctcatacc     1800

tcggccagcc acaggccttg cgtcaatggg gatgtagaca agccttcaga gccagcctct     1860

gaggagggct ctgagtcgga ggggagtgag tccagtggac gctcctgtcg gaatgagcgc     1920

agcatccagg agaagcttca ggtcctgatg gccgaaggtc tgcttcctgc tgtgaaagtc     1980

ttcctggact ggcttcggac caaccccgac ctcatcatcg tgtgtgcgca gagctctcaa     2040

agtctgtgga accgcctgtc tgtgttgctg aatctgttgc ctgctgctgg tgaactccag     2100

gagtctggcc tggccttgtg tcctgaggtc caagatcttc ttgaaggttg tgaactgcct     2160

gacctcccct ctagccttct gctcccagag gacatggctc ttcgtaacct gcccccgctc     2220

cgagctgccc acagacgctt taactttgac acggatcggc ccctgctcag caccttagag     2280

gagtcagtgg tgcgcatctg ctgcatccgc agctttggtc atttcatcgc ccgcctgcaa     2340

ggcagcatcc tgcagttcaa cccagaggtt ggcatcttcg tcagcattgc ccagtctgag     2400

caggagagcc tgctgcagca ggcccaggca cagttccgaa tggcacagga ggaagctcgt     2460

cggaacaggc tcatgagaga catggctcag ctacgacttc agctcgaagt gtctcagctg     2520

gagggcagcc tgcagcagcc caaggcccag tcagccatgt ctccctacct cgtccctgac     2580

acccaggccc tctgccacca tctccctgtc atccgccaac tggccaccag tggccgcttc     2640

attgtcatca tcccaaggac agtgatcgat ggcctggatt tgctgaagaa ggaacaccca     2700

ggggcccggg atgggattcg gtacctggag gcagagttta aaaaaggaaa caggtacatt     2760

cgctgccaga aagaggtggg aaagagcttt gagcggcata agctgaagag gcaggatgca     2820

gatgcctgga ctctctataa gatcctagac agctgcaaac agctgactct ggcccagggg     2880

gcaggtgagg aggatccgag tggcatggtg accatcatca caggccttcc actggacaac     2940

cccagcgtgc tttcaggccc catgcaggca gccctgcagg ccgctgccca cgccagtgtg     3000

gacatcaaga atgttctgga cttctacaag cagtggaagg aaattggttg a              3051


<210> 10
<211> 1016
<212> PRT
<213> Homo sapiens

<400> 10
Met Ser Gln Gly Pro Pro Thr Gly Glu Ser Ser Glu Pro Glu Ala Lys 
1               5                   10                  15      


Val Leu His Thr Lys Arg Leu Tyr Arg Ala Val Val Glu Ala Val His 
            20                  25                  30          


Arg Leu Asp Leu Ile Leu Cys Asn Lys Thr Ala Tyr Gln Glu Val Phe 
        35                  40                  45              


Lys Pro Glu Asn Ile Ser Leu Arg Asn Lys Leu Arg Glu Leu Cys Val 
    50                  55                  60                  


Lys Leu Met Phe Leu His Pro Val Asp Tyr Gly Arg Lys Ala Glu Glu 
65                  70                  75                  80  


Leu Leu Trp Arg Lys Val Tyr Tyr Glu Val Ile Gln Leu Ile Lys Thr 
                85                  90                  95      


Asn Lys Lys His Ile His Ser Arg Ser Thr Leu Glu Cys Ala Tyr Arg 
            100                 105                 110         


Thr His Leu Val Ala Gly Ile Gly Phe Tyr Gln His Leu Leu Leu Tyr 
        115                 120                 125             


Ile Gln Ser His Tyr Gln Leu Glu Leu Gln Cys Cys Ile Asp Trp Thr 
    130                 135                 140                 


His Val Thr Asp Pro Leu Ile Gly Cys Lys Lys Pro Val Ser Ala Ser 
145                 150                 155                 160 


Gly Lys Glu Met Asp Trp Ala Gln Met Ala Cys His Arg Cys Leu Val 
                165                 170                 175     


Tyr Leu Gly Asp Leu Ser Arg Tyr Gln Asn Glu Leu Ala Gly Val Asp 
            180                 185                 190         


Thr Glu Leu Leu Ala Glu Arg Phe Tyr Tyr Gln Ala Leu Ser Val Ala 
        195                 200                 205             


Pro Gln Ile Gly Met Pro Phe Asn Gln Leu Gly Thr Leu Ala Gly Ser 
    210                 215                 220                 


Lys Tyr Tyr Asn Val Glu Ala Met Tyr Cys Tyr Leu Arg Cys Ile Gln 
225                 230                 235                 240 


Ser Glu Val Ser Phe Glu Gly Ala Tyr Gly Asn Leu Lys Arg Leu Tyr 
                245                 250                 255     


Asp Lys Ala Ala Lys Met Tyr His Gln Leu Lys Lys Cys Glu Thr Arg 
            260                 265                 270         


Lys Leu Ser Pro Gly Lys Lys Arg Cys Lys Asp Ile Lys Arg Leu Leu 
        275                 280                 285             


Val Asn Phe Met Tyr Leu Gln Ser Leu Leu Gln Pro Lys Ser Ser Ser 
    290                 295                 300                 


Val Asp Ser Glu Leu Thr Ser Leu Cys Gln Ser Val Leu Glu Asp Phe 
305                 310                 315                 320 


Asn Leu Cys Leu Phe Tyr Leu Pro Ser Ser Pro Asn Leu Ser Leu Ala 
                325                 330                 335     


Ser Glu Asp Glu Glu Glu Tyr Glu Ser Gly Tyr Ala Phe Leu Pro Asp 
            340                 345                 350         


Leu Leu Ile Phe Gln Met Val Ile Ile Cys Leu Met Cys Val His Ser 
        355                 360                 365             


Leu Glu Arg Ala Gly Ser Lys Gln Tyr Ser Ala Ala Ile Ala Phe Thr 
    370                 375                 380                 


Leu Ala Leu Phe Ser His Leu Val Asn His Val Asn Ile Arg Leu Gln 
385                 390                 395                 400 


Ala Glu Leu Glu Glu Gly Glu Asn Pro Val Pro Ala Phe Gln Ser Asp 
                405                 410                 415     


Gly Thr Asp Glu Pro Glu Ser Lys Glu Pro Val Glu Lys Glu Glu Glu 
            420                 425                 430         


Pro Asp Pro Glu Pro Pro Pro Val Thr Pro Gln Val Gly Glu Gly Arg 
        435                 440                 445             


Lys Ser Arg Lys Phe Ser Arg Leu Ser Cys Leu Arg Arg Arg Arg His 
    450                 455                 460                 


Pro Pro Lys Val Gly Asp Asp Ser Asp Leu Ser Glu Gly Phe Glu Ser 
465                 470                 475                 480 


Asp Ser Ser His Asp Ser Ala Arg Ala Ser Glu Gly Ser Asp Ser Gly 
                485                 490                 495     


Ser Asp Lys Ser Leu Glu Gly Gly Gly Thr Ala Phe Asp Ala Glu Thr 
            500                 505                 510         


Asp Ser Glu Met Asn Ser Gln Glu Ser Arg Ser Asp Leu Glu Asp Met 
        515                 520                 525             


Glu Glu Glu Glu Gly Thr Arg Ser Pro Thr Leu Glu Pro Pro Arg Gly 
    530                 535                 540                 


Arg Ser Glu Ala Pro Asp Ser Leu Asn Gly Pro Leu Gly Pro Ser Glu 
545                 550                 555                 560 


Ala Ser Ile Ala Ser Asn Leu Gln Ala Met Ser Thr Gln Met Phe Gln 
                565                 570                 575     


Thr Lys Arg Cys Phe Arg Leu Ala Pro Thr Phe Ser Asn Leu Leu Leu 
            580                 585                 590         


Gln Pro Thr Thr Asn Pro His Thr Ser Ala Ser His Arg Pro Cys Val 
        595                 600                 605             


Asn Gly Asp Val Asp Lys Pro Ser Glu Pro Ala Ser Glu Glu Gly Ser 
    610                 615                 620                 


Glu Ser Glu Gly Ser Glu Ser Ser Gly Arg Ser Cys Arg Asn Glu Arg 
625                 630                 635                 640 


Ser Ile Gln Glu Lys Leu Gln Val Leu Met Ala Glu Gly Leu Leu Pro 
                645                 650                 655     


Ala Val Lys Val Phe Leu Asp Trp Leu Arg Thr Asn Pro Asp Leu Ile 
            660                 665                 670         


Ile Val Cys Ala Gln Ser Ser Gln Ser Leu Trp Asn Arg Leu Ser Val 
        675                 680                 685             


Leu Leu Asn Leu Leu Pro Ala Ala Gly Glu Leu Gln Glu Ser Gly Leu 
    690                 695                 700                 


Ala Leu Cys Pro Glu Val Gln Asp Leu Leu Glu Gly Cys Glu Leu Pro 
705                 710                 715                 720 


Asp Leu Pro Ser Ser Leu Leu Leu Pro Glu Asp Met Ala Leu Arg Asn 
                725                 730                 735     


Leu Pro Pro Leu Arg Ala Ala His Arg Arg Phe Asn Phe Asp Thr Asp 
            740                 745                 750         


Arg Pro Leu Leu Ser Thr Leu Glu Glu Ser Val Val Arg Ile Cys Cys 
        755                 760                 765             


Ile Arg Ser Phe Gly His Phe Ile Ala Arg Leu Gln Gly Ser Ile Leu 
    770                 775                 780                 


Gln Phe Asn Pro Glu Val Gly Ile Phe Val Ser Ile Ala Gln Ser Glu 
785                 790                 795                 800 


Gln Glu Ser Leu Leu Gln Gln Ala Gln Ala Gln Phe Arg Met Ala Gln 
                805                 810                 815     


Glu Glu Ala Arg Arg Asn Arg Leu Met Arg Asp Met Ala Gln Leu Arg 
            820                 825                 830         


Leu Gln Leu Glu Val Ser Gln Leu Glu Gly Ser Leu Gln Gln Pro Lys 
        835                 840                 845             


Ala Gln Ser Ala Met Ser Pro Tyr Leu Val Pro Asp Thr Gln Ala Leu 
    850                 855                 860                 


Cys His His Leu Pro Val Ile Arg Gln Leu Ala Thr Ser Gly Arg Phe 
865                 870                 875                 880 


Ile Val Ile Ile Pro Arg Thr Val Ile Asp Gly Leu Asp Leu Leu Lys 
                885                 890                 895     


Lys Glu His Pro Gly Ala Arg Asp Gly Ile Arg Tyr Leu Glu Ala Glu 
            900                 905                 910         


Phe Lys Lys Gly Asn Arg Tyr Ile Arg Cys Gln Lys Glu Val Gly Lys 
        915                 920                 925             


Ser Phe Glu Arg His Lys Leu Lys Arg Gln Asp Ala Asp Ala Trp Thr 
    930                 935                 940                 


Leu Tyr Lys Ile Leu Asp Ser Cys Lys Gln Leu Thr Leu Ala Gln Gly 
945                 950                 955                 960 


Ala Gly Glu Glu Asp Pro Ser Gly Met Val Thr Ile Ile Thr Gly Leu 
                965                 970                 975     


Pro Leu Asp Asn Pro Ser Val Leu Ser Gly Pro Met Gln Ala Ala Leu 
            980                 985                 990         


Gln Ala Ala Ala His Ala Ser Val  Asp Ile Lys Asn Val  Leu Asp Phe 
        995                 1000                 1005             


Tyr Lys  Gln Trp Lys Glu Ile  Gly 
    1010                 1015     


<210> 11
<211> 1536
<212> DNA
<213> Homo sapiens

<400> 11
atggagacat tccctgcagt ggctgagaag gtcctcaagg agttccaggt gttactgcag       60

cacagcccct ctcccattgg aagtacccgc atgctgcagc ttatgaccat caatatgttt      120

gcagtacaca actcccagct gaaagactgc ttctcggagg agtgccgctc tgtgatccag      180

gaacaagccg cagctctggg cttggccatg ttttctctac tggtccgccg ctgcacctgc      240

ttacttaagg agtccgccaa agctcagctg tcctctcctg aggaccagga tgaccaagac      300

gacatcaagg tgtcttcctt tgtcccggac ctgaaggagc tgctccccag tgtcaaagtc      360

tggtcagatt ggatgctcgg ctacccggac acctggaatc ctcctcccac atccctggat      420

ctgccctcgc atgttgctgt ggatgtatgg tcgacgctgg ctgatttctg taacatactg      480

actgcagtga atcagtctga ggtgccactg tacaaggacc cggatgatga cctcaccctt      540

cttatcctgg aagaggatcg gcttctctcg ggctttgtcc ccttgctggc tgcccctcag      600

gacccctgct acgtggagaa aacctcggat aaggttattg cagctgactg caaaagggtc      660

acagtgctga agtattttct ggaagccctt tgtggacaag aagagcctct gctggcattc      720

aagggtggaa agtatgtgtc agtggcaccc gtcccagaca ccatgggaaa ggaaatggga      780

agccaagagg gaacacgact ggaagatgag gaggaggatg tggtgattga agactttgag      840

gaagattcag aggctgaagg cagcggaggc gaggatgaca tcagggagct tcgggccaag      900

aagctggctc tggccaggaa gatagctgag cagcagcgtc gccaggaaaa gatccaggct      960

gtcctggagg accacagtca gatgaggcag atggagctcg aaatcagacc tttgttcctc     1020

gtaccagaca ccaacggctt cattgaccac ctggccagtc tggcgcggct gctggagagc     1080

aggaagtaca tcctggtggt gcccctcatc gtgatcaatg agctggacgg cctggccaag     1140

gggcaggaga cagaccaccg ggctgggggc tacgcccgtg tggtacaaga gaaggcccgc     1200

aagtccatcg agttcctcga gcagcgattc gagagtcggg actcttgcct gcgagccctg     1260

accagccgtg gcaatgaact cgaatccatc gccttccgca gtgaggacat cactggccag     1320

ctgggtaaca acgatgatct catcctgtcc tgctgcctcc actactgcaa agacaaggct     1380

aaggacttca tgcccgccag caaagaggag ccaatccggc tactgcggga ggtggtgctg     1440

ttgacggatg accggaacct gcgtgtgaag gcgctcacaa ggaatgttcc tgtacgggac     1500

atcccagcct tcctcacgtg ggcccaggtg ggctga                               1536


<210> 12
<211> 511
<212> PRT
<213> Homo sapiens

<400> 12
Met Glu Thr Phe Pro Ala Val Ala Glu Lys Val Leu Lys Glu Phe Gln 
1               5                   10                  15      


Val Leu Leu Gln His Ser Pro Ser Pro Ile Gly Ser Thr Arg Met Leu 
            20                  25                  30          


Gln Leu Met Thr Ile Asn Met Phe Ala Val His Asn Ser Gln Leu Lys 
        35                  40                  45              


Asp Cys Phe Ser Glu Glu Cys Arg Ser Val Ile Gln Glu Gln Ala Ala 
    50                  55                  60                  


Ala Leu Gly Leu Ala Met Phe Ser Leu Leu Val Arg Arg Cys Thr Cys 
65                  70                  75                  80  


Leu Leu Lys Glu Ser Ala Lys Ala Gln Leu Ser Ser Pro Glu Asp Gln 
                85                  90                  95      


Asp Asp Gln Asp Asp Ile Lys Val Ser Ser Phe Val Pro Asp Leu Lys 
            100                 105                 110         


Glu Leu Leu Pro Ser Val Lys Val Trp Ser Asp Trp Met Leu Gly Tyr 
        115                 120                 125             


Pro Asp Thr Trp Asn Pro Pro Pro Thr Ser Leu Asp Leu Pro Ser His 
    130                 135                 140                 


Val Ala Val Asp Val Trp Ser Thr Leu Ala Asp Phe Cys Asn Ile Leu 
145                 150                 155                 160 


Thr Ala Val Asn Gln Ser Glu Val Pro Leu Tyr Lys Asp Pro Asp Asp 
                165                 170                 175     


Asp Leu Thr Leu Leu Ile Leu Glu Glu Asp Arg Leu Leu Ser Gly Phe 
            180                 185                 190         


Val Pro Leu Leu Ala Ala Pro Gln Asp Pro Cys Tyr Val Glu Lys Thr 
        195                 200                 205             


Ser Asp Lys Val Ile Ala Ala Asp Cys Lys Arg Val Thr Val Leu Lys 
    210                 215                 220                 


Tyr Phe Leu Glu Ala Leu Cys Gly Gln Glu Glu Pro Leu Leu Ala Phe 
225                 230                 235                 240 


Lys Gly Gly Lys Tyr Val Ser Val Ala Pro Val Pro Asp Thr Met Gly 
                245                 250                 255     


Lys Glu Met Gly Ser Gln Glu Gly Thr Arg Leu Glu Asp Glu Glu Glu 
            260                 265                 270         


Asp Val Val Ile Glu Asp Phe Glu Glu Asp Ser Glu Ala Glu Gly Ser 
        275                 280                 285             


Gly Gly Glu Asp Asp Ile Arg Glu Leu Arg Ala Lys Lys Leu Ala Leu 
    290                 295                 300                 


Ala Arg Lys Ile Ala Glu Gln Gln Arg Arg Gln Glu Lys Ile Gln Ala 
305                 310                 315                 320 


Val Leu Glu Asp His Ser Gln Met Arg Gln Met Glu Leu Glu Ile Arg 
                325                 330                 335     


Pro Leu Phe Leu Val Pro Asp Thr Asn Gly Phe Ile Asp His Leu Ala 
            340                 345                 350         


Ser Leu Ala Arg Leu Leu Glu Ser Arg Lys Tyr Ile Leu Val Val Pro 
        355                 360                 365             


Leu Ile Val Ile Asn Glu Leu Asp Gly Leu Ala Lys Gly Gln Glu Thr 
    370                 375                 380                 


Asp His Arg Ala Gly Gly Tyr Ala Arg Val Val Gln Glu Lys Ala Arg 
385                 390                 395                 400 


Lys Ser Ile Glu Phe Leu Glu Gln Arg Phe Glu Ser Arg Asp Ser Cys 
                405                 410                 415     


Leu Arg Ala Leu Thr Ser Arg Gly Asn Glu Leu Glu Ser Ile Ala Phe 
            420                 425                 430         


Arg Ser Glu Asp Ile Thr Gly Gln Leu Gly Asn Asn Asp Asp Leu Ile 
        435                 440                 445             


Leu Ser Cys Cys Leu His Tyr Cys Lys Asp Lys Ala Lys Asp Phe Met 
    450                 455                 460                 


Pro Ala Ser Lys Glu Glu Pro Ile Arg Leu Leu Arg Glu Val Val Leu 
465                 470                 475                 480 


Leu Thr Asp Asp Arg Asn Leu Arg Val Lys Ala Leu Thr Arg Asn Val 
                485                 490                 495     


Pro Val Arg Asp Ile Pro Ala Phe Leu Thr Trp Ala Gln Val Gly 
            500                 505                 510     


<210> 13
<211> 3537
<212> DNA
<213> Homo sapiens

<400> 13
atgagcctgc agagcgcgca gtacctccgg caggcagaag tcctgaaggc tgacatgaca       60

gattctaagc tgggtccagc tgaagtctgg acatccaggc aggctctgca ggacctgtac      120

cagaaaatgc tagttaccga tttggaatac gctttagaca agaaagtaga acaggatctc      180

tggaatcacg cctttaagaa tcagatcaca acactacaag gccaggcaaa gaatcgagca      240

aatccgaatc ggagtgaagt tcaggcaaac ctttctctgt tcctagaggc agctagtggc      300

ttctatactc agttattaca agaactgtgt acagtattta atgtagattt accatgccgt      360

gtgaagtctt cccaattggg aattatcagc aataaacaga cgcataccag cgccatagtg      420

aagccacagt ctagctcctg ttcctatatc tgccagcact gcctcgtcca ccttggagac      480

attgctcgat acagaaacca gaccagccag gcagagtcct actataggca tgcagctcag      540

cttgtcccct ccaatggtca gccttataat cagttggcta tcttagcttc ttccaaagga      600

gaccatctga ccacaatttt ctactactgc agaagcattg ctgtgaagtt ccctttccca      660

gctgcctcca ctaatctgca aaaagcactt tctaaagcac tggaaagccg agatgaggtg      720

aaaaccaagt ggggtgtttc tgacttcatc aaggccttta ttaaattcca cggtcatgtg      780

tacctgagta agagcttgga aaagttgagc cctcttcgag agaaattgga agaacagttt      840

aagaggctgc tattccaaaa agctttcaac tctcagcagt tagttcatgt cactgtcatt      900

aacctgtttc aacttcatca ccttcgtgac tttagcaatg aaaccgagca gcacacttat      960

agccaagatg agcagctatg ttggacacag ttgctggccc tctttatgtc ttttctcggc     1020

atcctgtgca agtgtcctct acagaatgag tctcaggagg agtcctacaa tgcctatcct     1080

cttccagcag tcaaggtctc catggactgg ctaagactca gacccagggt ctttcaggag     1140

gcagtggtgg atgaaagaca gtacatttgg ccctggttga tttctcttct gaatagtttc     1200

catccccatg aagaggacct ctcaagtatt agtgcgacac cacttccaga ggagtttgaa     1260

ttacaaggat ttttggcatt gagaccttct ttcaggaact tggatttttc caaaggtcac     1320

cagggtatta caggggacaa agaaggccag caacgacgaa tacgacagca acgcttgatc     1380

tctataggca aatggattgc tgataatcag ccaaggctga ttcagtgtga aaatgaggta     1440

gggaaattgt tgtttatcac agaaatccca gaattaatac tggaagaccc cagtgaagcc     1500

aaagagaacc tcattctgca agaaacatct gtgatagagt cgctggctgc agatgggagc     1560

ccagggctaa aatcagtgct atctacaagc cgaaatttaa gcaacaactg tgacacagga     1620

gagaagccag tggttacctt caaagaaaac attaagacac gagaagtgaa cagagaccaa     1680

ggaagaagtt ttcctcccaa agaggtaaaa tcccagacag aactaagaaa gactccagtg     1740

tctgaagcca gaaaaacacc tgtaactcaa accccaactc aagcaagtaa ctcccagttc     1800

atccccattc atcaccctgg agccttccct cctcttccca gcaggccagg gtttccgccc     1860

ccaacatatg ttatcccccc gcctgtggca ttttctatgg gctcaggtta caccttccca     1920

gctggtgttt ctgtcccagg aacctttctt cagcctacag ctcactctcc agcaggaaac     1980

caggtgcaag ctgggaaaca gtcccacatt ccttacagcc agcaacggcc ctctggacca     2040

gggccaatga accagggacc tcaacaatca cagccacctt cccagcaacc ccttacatct     2100

ttaccagctc agccaacagc acagtctaca agccagctgc aggttcaagc tctaactcag     2160

caacaacaat cccctacaaa agctgtgccg gctttgggga aaagcccgcc tcaccactct     2220

ggattccagc agtatcaaca ggcagatgcc tccaaacagc tgtggaatcc ccctcaggtt     2280

caaggcccat tagggaaaat tatgcctgtg aaacagccct actaccttca gacccaagac     2340

cccataaaac tgtttgagcc gtcattgcaa cctcctgtaa tgcagcagca gcctctagaa     2400

aaaaaaatga agccttttcc catggagcca tataaccata atccctcaga agtcaaggtc     2460

ccagaattct actgggattc ttcctacagc atggctgata acagatctgt aatggcacag     2520

caagcaaaca tagaccgcag gggcaaacgg tcaccaggaa tcttccgtcc agagcaggat     2580

cctgtaccca gaatgccgtt tgaggacccc aagagctccc ctctgcttcc tccggacctg     2640

ttaaagagtc tggctgcctt ggaggaagag gaagagctga ttttttctaa cactcctgat     2700

ctttacccgg ctctgctggg gcctctcgcc tctcttcctg gacgaagcct ttttaaatcc     2760

ttattggaga agccctcaga gctcatgtca cattcatcct ctttcctgtc cctcaccgga     2820

ttctctctca atcaggaaag atacccaaat aatagtatgt tcaatgaggt atatgggaaa     2880

aacctgacat ccagctccaa agcagaactc agtccctcaa tggcccccca ggaaacatct     2940

ctgtattccc tttttgaagg gactccgtgg tctccatcac ttcctgccag ttcagatcat     3000

tcaacaccag ccagccagtc tcctcattcc tctaacccaa gcagcctacc cagctctcct     3060

ccaacacaca accataattc tgttccattc tccaattttg gacccattgg gactccagat     3120

aacagggata gaaggactgc agatcggtgg aaaactgata agccagccat gggtgggttt     3180

ggcattgatt atctctcagc aacgtcatcc tctgagagca gttggcatca ggccagcact     3240

ccgagtggca cctggacagg ccatggccct tccatggagg attcctctgc tgtcctcatg     3300

gaaagcctaa agaagcaaca gcatggggtc cagcagttgg ggcccaaaag acagtctgaa     3360

gaggaaggaa gcagcagtat ctgcgtagcc cacagagggc ccaggcccct gcccagctgc     3420

agtctcccag cctccacttt cagagtgaaa ttcaaggcag cacggacatg tgcccatcag     3480

gcacagaaga aaacacgacg tcgtccattt tggaagagac gaaagaaagg aaaataa        3537


<210> 14
<211> 1178
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Leu Gln Ser Ala Gln Tyr Leu Arg Gln Ala Glu Val Leu Lys 
1               5                   10                  15      


Ala Asp Met Thr Asp Ser Lys Leu Gly Pro Ala Glu Val Trp Thr Ser 
            20                  25                  30          


Arg Gln Ala Leu Gln Asp Leu Tyr Gln Lys Met Leu Val Thr Asp Leu 
        35                  40                  45              


Glu Tyr Ala Leu Asp Lys Lys Val Glu Gln Asp Leu Trp Asn His Ala 
    50                  55                  60                  


Phe Lys Asn Gln Ile Thr Thr Leu Gln Gly Gln Ala Lys Asn Arg Ala 
65                  70                  75                  80  


Asn Pro Asn Arg Ser Glu Val Gln Ala Asn Leu Ser Leu Phe Leu Glu 
                85                  90                  95      


Ala Ala Ser Gly Phe Tyr Thr Gln Leu Leu Gln Glu Leu Cys Thr Val 
            100                 105                 110         


Phe Asn Val Asp Leu Pro Cys Arg Val Lys Ser Ser Gln Leu Gly Ile 
        115                 120                 125             


Ile Ser Asn Lys Gln Thr His Thr Ser Ala Ile Val Lys Pro Gln Ser 
    130                 135                 140                 


Ser Ser Cys Ser Tyr Ile Cys Gln His Cys Leu Val His Leu Gly Asp 
145                 150                 155                 160 


Ile Ala Arg Tyr Arg Asn Gln Thr Ser Gln Ala Glu Ser Tyr Tyr Arg 
                165                 170                 175     


His Ala Ala Gln Leu Val Pro Ser Asn Gly Gln Pro Tyr Asn Gln Leu 
            180                 185                 190         


Ala Ile Leu Ala Ser Ser Lys Gly Asp His Leu Thr Thr Ile Phe Tyr 
        195                 200                 205             


Tyr Cys Arg Ser Ile Ala Val Lys Phe Pro Phe Pro Ala Ala Ser Thr 
    210                 215                 220                 


Asn Leu Gln Lys Ala Leu Ser Lys Ala Leu Glu Ser Arg Asp Glu Val 
225                 230                 235                 240 


Lys Thr Lys Trp Gly Val Ser Asp Phe Ile Lys Ala Phe Ile Lys Phe 
                245                 250                 255     


His Gly His Val Tyr Leu Ser Lys Ser Leu Glu Lys Leu Ser Pro Leu 
            260                 265                 270         


Arg Glu Lys Leu Glu Glu Gln Phe Lys Arg Leu Leu Phe Gln Lys Ala 
        275                 280                 285             


Phe Asn Ser Gln Gln Leu Val His Val Thr Val Ile Asn Leu Phe Gln 
    290                 295                 300                 


Leu His His Leu Arg Asp Phe Ser Asn Glu Thr Glu Gln His Thr Tyr 
305                 310                 315                 320 


Ser Gln Asp Glu Gln Leu Cys Trp Thr Gln Leu Leu Ala Leu Phe Met 
                325                 330                 335     


Ser Phe Leu Gly Ile Leu Cys Lys Cys Pro Leu Gln Asn Glu Ser Gln 
            340                 345                 350         


Glu Glu Ser Tyr Asn Ala Tyr Pro Leu Pro Ala Val Lys Val Ser Met 
        355                 360                 365             


Asp Trp Leu Arg Leu Arg Pro Arg Val Phe Gln Glu Ala Val Val Asp 
    370                 375                 380                 


Glu Arg Gln Tyr Ile Trp Pro Trp Leu Ile Ser Leu Leu Asn Ser Phe 
385                 390                 395                 400 


His Pro His Glu Glu Asp Leu Ser Ser Ile Ser Ala Thr Pro Leu Pro 
                405                 410                 415     


Glu Glu Phe Glu Leu Gln Gly Phe Leu Ala Leu Arg Pro Ser Phe Arg 
            420                 425                 430         


Asn Leu Asp Phe Ser Lys Gly His Gln Gly Ile Thr Gly Asp Lys Glu 
        435                 440                 445             


Gly Gln Gln Arg Arg Ile Arg Gln Gln Arg Leu Ile Ser Ile Gly Lys 
    450                 455                 460                 


Trp Ile Ala Asp Asn Gln Pro Arg Leu Ile Gln Cys Glu Asn Glu Val 
465                 470                 475                 480 


Gly Lys Leu Leu Phe Ile Thr Glu Ile Pro Glu Leu Ile Leu Glu Asp 
                485                 490                 495     


Pro Ser Glu Ala Lys Glu Asn Leu Ile Leu Gln Glu Thr Ser Val Ile 
            500                 505                 510         


Glu Ser Leu Ala Ala Asp Gly Ser Pro Gly Leu Lys Ser Val Leu Ser 
        515                 520                 525             


Thr Ser Arg Asn Leu Ser Asn Asn Cys Asp Thr Gly Glu Lys Pro Val 
    530                 535                 540                 


Val Thr Phe Lys Glu Asn Ile Lys Thr Arg Glu Val Asn Arg Asp Gln 
545                 550                 555                 560 


Gly Arg Ser Phe Pro Pro Lys Glu Val Lys Ser Gln Thr Glu Leu Arg 
                565                 570                 575     


Lys Thr Pro Val Ser Glu Ala Arg Lys Thr Pro Val Thr Gln Thr Pro 
            580                 585                 590         


Thr Gln Ala Ser Asn Ser Gln Phe Ile Pro Ile His His Pro Gly Ala 
        595                 600                 605             


Phe Pro Pro Leu Pro Ser Arg Pro Gly Phe Pro Pro Pro Thr Tyr Val 
    610                 615                 620                 


Ile Pro Pro Pro Val Ala Phe Ser Met Gly Ser Gly Tyr Thr Phe Pro 
625                 630                 635                 640 


Ala Gly Val Ser Val Pro Gly Thr Phe Leu Gln Pro Thr Ala His Ser 
                645                 650                 655     


Pro Ala Gly Asn Gln Val Gln Ala Gly Lys Gln Ser His Ile Pro Tyr 
            660                 665                 670         


Ser Gln Gln Arg Pro Ser Gly Pro Gly Pro Met Asn Gln Gly Pro Gln 
        675                 680                 685             


Gln Ser Gln Pro Pro Ser Gln Gln Pro Leu Thr Ser Leu Pro Ala Gln 
    690                 695                 700                 


Pro Thr Ala Gln Ser Thr Ser Gln Leu Gln Val Gln Ala Leu Thr Gln 
705                 710                 715                 720 


Gln Gln Gln Ser Pro Thr Lys Ala Val Pro Ala Leu Gly Lys Ser Pro 
                725                 730                 735     


Pro His His Ser Gly Phe Gln Gln Tyr Gln Gln Ala Asp Ala Ser Lys 
            740                 745                 750         


Gln Leu Trp Asn Pro Pro Gln Val Gln Gly Pro Leu Gly Lys Ile Met 
        755                 760                 765             


Pro Val Lys Gln Pro Tyr Tyr Leu Gln Thr Gln Asp Pro Ile Lys Leu 
    770                 775                 780                 


Phe Glu Pro Ser Leu Gln Pro Pro Val Met Gln Gln Gln Pro Leu Glu 
785                 790                 795                 800 


Lys Lys Met Lys Pro Phe Pro Met Glu Pro Tyr Asn His Asn Pro Ser 
                805                 810                 815     


Glu Val Lys Val Pro Glu Phe Tyr Trp Asp Ser Ser Tyr Ser Met Ala 
            820                 825                 830         


Asp Asn Arg Ser Val Met Ala Gln Gln Ala Asn Ile Asp Arg Arg Gly 
        835                 840                 845             


Lys Arg Ser Pro Gly Ile Phe Arg Pro Glu Gln Asp Pro Val Pro Arg 
    850                 855                 860                 


Met Pro Phe Glu Asp Pro Lys Ser Ser Pro Leu Leu Pro Pro Asp Leu 
865                 870                 875                 880 


Leu Lys Ser Leu Ala Ala Leu Glu Glu Glu Glu Glu Leu Ile Phe Ser 
                885                 890                 895     


Asn Thr Pro Asp Leu Tyr Pro Ala Leu Leu Gly Pro Leu Ala Ser Leu 
            900                 905                 910         


Pro Gly Arg Ser Leu Phe Lys Ser Leu Leu Glu Lys Pro Ser Glu Leu 
        915                 920                 925             


Met Ser His Ser Ser Ser Phe Leu Ser Leu Thr Gly Phe Ser Leu Asn 
    930                 935                 940                 


Gln Glu Arg Tyr Pro Asn Asn Ser Met Phe Asn Glu Val Tyr Gly Lys 
945                 950                 955                 960 


Asn Leu Thr Ser Ser Ser Lys Ala Glu Leu Ser Pro Ser Met Ala Pro 
                965                 970                 975     


Gln Glu Thr Ser Leu Tyr Ser Leu Phe Glu Gly Thr Pro Trp Ser Pro 
            980                 985                 990         


Ser Leu Pro Ala Ser Ser Asp His  Ser Thr Pro Ala Ser  Gln Ser Pro 
        995                 1000                 1005             


His Ser  Ser Asn Pro Ser Ser  Leu Pro Ser Ser Pro  Pro Thr His 
    1010                 1015                 1020             


Asn His  Asn Ser Val Pro Phe  Ser Asn Phe Gly Pro  Ile Gly Thr 
    1025                 1030                 1035             


Pro Asp  Asn Arg Asp Arg Arg  Thr Ala Asp Arg Trp  Lys Thr Asp 
    1040                 1045                 1050             


Lys Pro  Ala Met Gly Gly Phe  Gly Ile Asp Tyr Leu  Ser Ala Thr 
    1055                 1060                 1065             


Ser Ser  Ser Glu Ser Ser Trp  His Gln Ala Ser Thr  Pro Ser Gly 
    1070                 1075                 1080             


Thr Trp  Thr Gly His Gly Pro  Ser Met Glu Asp Ser  Ser Ala Val 
    1085                 1090                 1095             


Leu Met  Glu Ser Leu Lys Lys  Gln Gln His Gly Val  Gln Gln Leu 
    1100                 1105                 1110             


Gly Pro  Lys Arg Gln Ser Glu  Glu Glu Gly Ser Ser  Ser Ile Cys 
    1115                 1120                 1125             


Val Ala  His Arg Gly Pro Arg  Pro Leu Pro Ser Cys  Ser Leu Pro 
    1130                 1135                 1140             


Ala Ser  Thr Phe Arg Val Lys  Phe Lys Ala Ala Arg  Thr Cys Ala 
    1145                 1150                 1155             


His Gln  Ala Gln Lys Lys Thr  Arg Arg Arg Pro Phe  Trp Lys Arg 
    1160                 1165                 1170             


Arg Lys  Lys Gly Lys 
    1175             


