                         SEQUENCE LISTING

<110>  Agrivida, Inc.
       Raab, Michael
 
<120>  PRODUCTION OF INTEIN - MODIFIED PROTEASES AND ASSOCIATED USES

<130>  AGR-PT017.1WO

<150>  61/744,863
<151>  2012-10-03

<150>  61/783,424
<151>  2013-03-14

<160>  718   

<170>  PatentIn version 3.5

<210>  1
<211>  380
<212>  PRT
<213>  Bacillus lentus


<220>
<221>  MISC_FEATURE
<222>  (1)..(380)
<223>  P29600

<400>  1

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            260                 265                 270         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        275                 280                 285             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    290                 295                 300                 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
305                 310                 315                 320 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
                325                 330                 335     


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
            340                 345                 350         


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
        355                 360                 365             


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    370                 375                 380 


<210>  2
<211>  269
<212>  PRT
<213>  Bacillus lentus


<220>
<221>  MISC_FEATURE
<222>  (1)..(269)
<223>  P29599

<400>  2

Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala 
1               5                   10                  15      


His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser 
        35                  40                  45              


Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr 
    50                  55                  60                  


His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu 
65                  70                  75                  80  


Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala 
                85                  90                  95      


Asp Gly Arg Gly Ala Ile Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala 
            100                 105                 110         


Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser 
        115                 120                 125             


Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly 
    130                 135                 140                 


Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Ser Ser Ile Ser 
145                 150                 155                 160 


Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln 
                165                 170                 175     


Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile 
            180                 185                 190         


Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr 
        195                 200                 205             


Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
    210                 215                 220                 


Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile 
225                 230                 235                 240 


Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu 
                245                 250                 255     


Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            260                 265                 


<210>  3
<211>  275
<212>  PRT
<213>  Bacillus pumilus


<220>
<221>  MISC_FEATURE
<222>  (1)..(275)
<223>  P07518

<400>  3

Ala Gln Ser Val Pro Tyr Gly Ile Ser Gln Ile Lys Ala Pro Ala Leu 
1               5                   10                  15      


His Ser Gln Gly Tyr Thr Gly Ser Asn Val Lys Val Ala Val Ile Asp 
            20                  25                  30          


Ser Gly Ile Asp Ser Ser His Pro Asp Leu Asn Val Arg Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Pro Ser Glu Thr Asn Pro Tyr Gln Asp Gly Ser Ser His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Ser Ser Ala Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Asp Ser Thr Gly Ser Gly Gln Tyr Ser Trp Ile Ile Asn Gly Ile Glu 
            100                 105                 110         


Trp Ala Ile Ser Asn Asn Met Asp Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Pro Thr Gly Ser Thr Ala Leu Lys Thr Val Val Asp Lys Ala Val Ser 
    130                 135                 140                 


Ser Gly Ile Val Val Ala Ala Ala Ala Gly Asn Glu Gly Ser Ser Gly 
145                 150                 155                 160 


Ser Thr Ser Thr Val Gly Tyr Pro Ala Lys Tyr Pro Ser Thr Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asn Ser Ala Asn Gln Arg Ala Ser Phe Ser Ser Ala 
            180                 185                 190         


Gly Ser Glu Leu Asp Val Met Ala Pro Gly Val Ser Ile Gln Ser Thr 
        195                 200                 205             


Leu Pro Gly Gly Thr Tyr Gly Ala Tyr Asn Gly Thr Ser Met Ala Thr 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Leu Ser Lys His Pro Thr 
225                 230                 235                 240 


Trp Thr Asn Ala Gln Val Arg Asp Arg Leu Glu Ser Thr Ala Thr Tyr 
                245                 250                 255     


Leu Gly Ser Ser Phe Tyr Tyr Gly Lys Gly Leu Ile Asn Val Gln Ala 
            260                 265                 270         


Ala Ala Gln 
        275 


<210>  4
<211>  381
<212>  PRT
<213>  Bacillus subtilis


<220>
<221>  MISC_FEATURE
<222>  (1)..(381)
<223>  P04189

<400>  4

Met Arg Ser Lys Lys Leu Trp Ile Ser Leu Leu Phe Ala Leu Thr Leu 
1               5                   10                  15      


Ile Phe Thr Met Ala Phe Ser Asn Met Ser Ala Gln Ala Ala Gly Lys 
            20                  25                  30          


Ser Ser Thr Glu Lys Lys Tyr Ile Val Gly Phe Lys Gln Thr Met Ser 
        35                  40                  45              


Ala Met Ser Ser Ala Lys Lys Lys Asp Val Ile Ser Glu Lys Gly Gly 
    50                  55                  60                  


Lys Val Gln Lys Gln Phe Lys Tyr Val Asn Ala Ala Ala Ala Thr Leu 
65                  70                  75                  80  


Asp Glu Lys Ala Val Lys Glu Leu Lys Lys Asp Pro Ser Val Ala Tyr 
                85                  90                  95      


Val Glu Glu Asp His Ile Ala His Glu Tyr Ala Gln Ser Val Pro Tyr 
            100                 105                 110         


Gly Ile Ser Gln Ile Lys Ala Pro Ala Leu His Ser Gln Gly Tyr Thr 
        115                 120                 125             


Gly Ser Asn Val Lys Val Ala Val Ile Asp Ser Gly Ile Asp Ser Ser 
    130                 135                 140                 


His Pro Asp Leu Asn Val Arg Gly Gly Ala Ser Phe Val Pro Ser Glu 
145                 150                 155                 160 


Thr Asn Pro Tyr Gln Asp Gly Ser Ser His Gly Thr His Val Ala Gly 
                165                 170                 175     


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro 
            180                 185                 190         


Ser Ala Ser Leu Tyr Ala Val Lys Val Leu Asp Ser Thr Gly Ser Gly 
        195                 200                 205             


Gln Tyr Ser Trp Ile Ile Asn Gly Ile Glu Trp Ala Ile Ser Asn Asn 
    210                 215                 220                 


Met Asp Val Ile Asn Met Ser Leu Gly Gly Pro Thr Gly Ser Thr Ala 
225                 230                 235                 240 


Leu Lys Thr Val Val Asp Lys Ala Val Ser Ser Gly Ile Val Val Ala 
                245                 250                 255     


Ala Ala Ala Gly Asn Glu Gly Ser Ser Gly Ser Thr Ser Thr Val Gly 
            260                 265                 270         


Tyr Pro Ala Lys Tyr Pro Ser Thr Ile Ala Val Gly Ala Val Asn Ser 
        275                 280                 285             


Ser Asn Gln Arg Ala Ser Phe Ser Ser Ala Gly Ser Glu Leu Asp Val 
    290                 295                 300                 


Met Ala Pro Gly Val Ser Ile Gln Ser Thr Leu Pro Gly Gly Thr Tyr 
305                 310                 315                 320 


Gly Ala Tyr Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
                325                 330                 335     


Ala Ala Leu Ile Leu Ser Lys His Pro Thr Trp Thr Asn Ala Gln Val 
            340                 345                 350         


Arg Asp Arg Leu Glu Ser Thr Ala Thr Tyr Leu Gly Asn Ser Phe Tyr 
        355                 360                 365             


Tyr Gly Lys Gly Leu Ile Asn Val Gln Ala Ala Ala Gln 
    370                 375                 380     


<210>  5
<211>  274
<212>  PRT
<213>  Bacillus licheniformis


<220>
<221>  MISC_FEATURE
<222>  (1)..(274)
<223>  P00781

<400>  5

Ala Gln Thr Val Pro Tyr Gly Ile Pro Leu Ile Lys Ala Asp Lys Val 
1               5                   10                  15      


Gln Ala Gln Gly Tyr Lys Gly Ala Asn Val Lys Val Gly Ile Ile Asp 
            20                  25                  30          


Thr Gly Ile Ala Ala Ser His Thr Asp Leu Lys Val Val Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Ser Tyr Asn Thr Asp Gly Asn Gly His Gly 
    50                  55                  60                  


Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly Val 
65                  70                  75                  80  


Leu Gly Val Ala Pro Asn Val Ser Leu Tyr Ala Ile Lys Val Leu Asn 
                85                  90                  95      


Ser Ser Gly Ser Gly Thr Tyr Ser Ala Ile Val Ser Gly Ile Glu Trp 
            100                 105                 110         


Ala Thr Gln Asn Gly Leu Asp Val Ile Asn Met Ser Leu Gly Gly Pro 
        115                 120                 125             


Ser Gly Ser Thr Ala Leu Lys Gln Ala Val Asp Lys Ala Tyr Ala Ser 
    130                 135                 140                 


Gly Ile Val Val Val Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly Ser 
145                 150                 155                 160 


Gln Asn Thr Ile Gly Tyr Pro Ala Lys Tyr Asp Ser Val Ile Ala Val 
                165                 170                 175     


Gly Ala Val Asp Ser Asn Lys Asn Arg Ala Ser Phe Ser Ser Val Gly 
            180                 185                 190         


Ala Glu Leu Glu Val Met Ala Pro Gly Val Ser Val Tyr Ser Thr Tyr 
        195                 200                 205             


Pro Ser Asn Thr Tyr Thr Ser Leu Asn Gly Thr Ser Met Ala Ser Pro 
    210                 215                 220                 


His Val Ala Gly Ala Ala Ala Leu Ile Leu Ser Lys Tyr Pro Thr Leu 
225                 230                 235                 240 


Ser Ala Ser Gln Val Arg Asn Arg Leu Ser Ser Thr Ala Thr Asn Leu 
                245                 250                 255     


Gly Asp Ser Phe Tyr Tyr Gly Lys Gly Leu Ile Asn Val Glu Ala Ala 
            260                 265                 270         


Ala Gln 
        


<210>  6
<211>  382
<212>  PRT
<213>  Bacillus amyloliquefaciens


<220>
<221>  MISC_FEATURE
<222>  (1)..(382)
<223>  P00782

<400>  6

Met Arg Gly Lys Lys Val Trp Ile Ser Leu Leu Phe Ala Leu Ala Leu 
1               5                   10                  15      


Ile Phe Thr Met Ala Phe Gly Ser Thr Ser Ser Ala Gln Ala Ala Gly 
            20                  25                  30          


Lys Ser Asn Gly Glu Lys Lys Tyr Ile Val Gly Phe Lys Gln Thr Met 
        35                  40                  45              


Ser Thr Met Ser Ala Ala Lys Lys Lys Asp Val Ile Ser Glu Lys Gly 
    50                  55                  60                  


Gly Lys Val Gln Lys Gln Phe Lys Tyr Val Asp Ala Ala Ser Ala Thr 
65                  70                  75                  80  


Leu Asn Glu Lys Ala Val Lys Glu Leu Lys Lys Asp Pro Ser Val Ala 
                85                  90                  95      


Tyr Val Glu Glu Asp His Val Ala His Ala Tyr Ala Gln Ser Val Pro 
            100                 105                 110         


Tyr Gly Val Ser Gln Ile Lys Ala Pro Ala Leu His Ser Gln Gly Tyr 
        115                 120                 125             


Thr Gly Ser Asn Val Lys Val Ala Val Ile Asp Ser Gly Ile Asp Ser 
    130                 135                 140                 


Ser His Pro Asp Leu Lys Val Ala Gly Gly Ala Ser Met Val Pro Ser 
145                 150                 155                 160 


Glu Thr Asn Pro Phe Gln Asp Asn Asn Ser His Gly Thr His Val Ala 
                165                 170                 175     


Gly Thr Val Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
            180                 185                 190         


Pro Ser Ala Ser Leu Tyr Ala Val Lys Val Leu Gly Ala Asp Gly Ser 
        195                 200                 205             


Gly Gln Tyr Ser Trp Ile Ile Asn Gly Ile Glu Trp Ala Ile Ala Asn 
    210                 215                 220                 


Asn Met Asp Val Ile Asn Met Ser Leu Gly Gly Pro Ser Gly Ser Ala 
225                 230                 235                 240 


Ala Leu Lys Ala Ala Val Asp Lys Ala Val Ala Ser Gly Val Val Val 
                245                 250                 255     


Val Ala Ala Ala Gly Asn Glu Gly Thr Ser Gly Ser Ser Ser Thr Val 
            260                 265                 270         


Gly Tyr Pro Gly Lys Tyr Pro Ser Val Ile Ala Val Gly Ala Val Asp 
        275                 280                 285             


Ser Ser Asn Gln Arg Ala Ser Phe Ser Ser Val Gly Pro Glu Leu Asp 
    290                 295                 300                 


Val Met Ala Pro Gly Val Ser Ile Gln Ser Thr Leu Pro Gly Asn Lys 
305                 310                 315                 320 


Tyr Gly Ala Tyr Asn Gly Thr Ser Met Ala Ser Pro His Val Ala Gly 
                325                 330                 335     


Ala Ala Ala Leu Ile Leu Ser Lys His Pro Asn Trp Thr Asn Thr Gln 
            340                 345                 350         


Val Arg Ser Ser Leu Glu Asn Thr Thr Thr Lys Leu Gly Asp Ser Phe 
        355                 360                 365             


Tyr Tyr Gly Lys Gly Leu Ile Asn Val Gln Ala Ala Ala Gln 
    370                 375                 380         


<210>  7
<211>  420
<212>  PRT
<213>  Bacillus sp. TA39


<220>
<221>  MISC_FEATURE
<222>  (1)..(420)
<223>  P28842

<400>  7

Met Lys Arg Ser Gly Lys Ile Phe Thr Thr Ala Met Leu Ala Val Thr 
1               5                   10                  15      


Leu Met Met Pro Ala Met Gly Val Ser Ala Asn Glu Gly Asn Ala Ala 
            20                  25                  30          


Ala Glu Gly Asn Glu Lys Phe Arg Val Leu Val Asp Ser Val Asp Gln 
        35                  40                  45              


Lys Asn Leu Lys Asn Ala Lys Gln Gln Tyr Gly Val His Trp Asp Phe 
    50                  55                  60                  


Ala Gly Glu Gly Phe Thr Thr Asp Met Asn Glu Lys Gln Phe Asn Ala 
65                  70                  75                  80  


Leu Lys Lys Asn Lys Asn Leu Thr Val Glu Lys Val Pro Glu Leu Glu 
                85                  90                  95      


Ile Ala Thr Ala Thr Asp Lys Pro Glu Ala Leu Tyr Asn Ala Met Ala 
            100                 105                 110         


Ala Ser Gln Ser Thr Pro Trp Gly Ile Lys Ala Ile Tyr Asn Asn Ser 
        115                 120                 125             


Ser Ile Thr Gln Thr Ser Gly Gly Gly Gly Ile Asn Ile Ala Val Leu 
    130                 135                 140                 


Asp Thr Gly Val Asn Thr Asn His Pro Asp Leu Arg Asn Asn Val Glu 
145                 150                 155                 160 


Gln Cys Lys Asp Phe Thr Val Gly Thr Thr Tyr Thr Asn Asn Ser Cys 
                165                 170                 175     


Thr Asp Arg Gln Gly His Gly Thr His Val Ala Gly Ser Ala Leu Ala 
            180                 185                 190         


Asp Gly Gly Thr Gly Asn Gly Val Tyr Gly Val Ala Pro Asp Ala Asp 
        195                 200                 205             


Leu Trp Ala Tyr Lys Val Leu Gly Asp Asp Gly Ser Gly Tyr Ala Asp 
    210                 215                 220                 


Asp Ile Ala Ala Ala Ile Arg His Ala Gly Asp Gln Ala Thr Ala Leu 
225                 230                 235                 240 


Asn Thr Lys Val Val Ile Asn Met Ser Leu Gly Ser Ser Gly Glu Ser 
                245                 250                 255     


Ser Leu Ile Thr Asn Ala Val Asn Tyr Ser Tyr Asn Lys Gly Val Leu 
            260                 265                 270         


Ile Ile Ala Ala Ala Gly Asn Ser Gly Pro Tyr Gln Gly Ser Ile Gly 
        275                 280                 285             


Tyr Pro Gly Ala Leu Val Asn Ala Val Ala Val Ala Ala Leu Glu Asn 
    290                 295                 300                 


Lys Val Glu Asn Gly Thr Tyr Arg Val Ala Asp Phe Ser Ser Arg Gly 
305                 310                 315                 320 


Tyr Ser Trp Thr Asp Gly Asp Tyr Ala Ile Gln Lys Gly Asp Val Glu 
                325                 330                 335     


Ile Ser Ala Pro Gly Ala Ala Ile Tyr Ser Thr Trp Phe Asp Gly Gly 
            340                 345                 350         


Tyr Ala Thr Ile Ser Gly Thr Ser Met Ala Ser Pro His Ala Ala Gly 
        355                 360                 365             


Leu Ala Ala Lys Ile Trp Ala Gln Tyr Pro Ser Ala Ser Asn Val Asp 
    370                 375                 380                 


Val Arg Gly Glu Leu Gln Tyr Arg Ala Tyr Glu Asn Asp Ile Leu Ser 
385                 390                 395                 400 


Gly Tyr Tyr Ala Gly Tyr Gly Asp Asp Phe Ala Ser Gly Phe Gly Phe 
                405                 410                 415     


Ala Thr Val Gln 
            420 


<210>  8
<211>  381
<212>  PRT
<213>  Bacillus stearothermophilus


<220>
<221>  MISC_FEATURE
<222>  (1)..(381)
<223>  P29142

<400>  8

Met Arg Ser Lys Lys Leu Trp Ile Ser Leu Leu Phe Ala Leu Thr Leu 
1               5                   10                  15      


Ile Phe Thr Met Ala Phe Ser Asn Met Ser Val Gln Ala Ala Gly Lys 
            20                  25                  30          


Ser Ser Thr Glu Lys Lys Tyr Ile Val Gly Phe Lys Gln Thr Met Ser 
        35                  40                  45              


Ala Met Ser Ser Ala Lys Lys Lys Asp Val Ile Ser Glu Lys Gly Gly 
    50                  55                  60                  


Lys Val Gln Lys Gln Phe Lys Tyr Val Asn Ala Ala Ala Ala Thr Leu 
65                  70                  75                  80  


Asp Glu Lys Ala Val Lys Glu Leu Lys Lys Asp Pro Ser Val Ala Tyr 
                85                  90                  95      


Val Glu Glu Asp His Ile Ala His Glu Tyr Ala Gln Ser Val Pro Tyr 
            100                 105                 110         


Gly Ile Ser Gln Ile Lys Ala Pro Ala Leu His Ser Gln Gly Tyr Thr 
        115                 120                 125             


Gly Ser Asn Val Lys Val Ala Val Ile Asp Ser Gly Ile Asp Ser Ser 
    130                 135                 140                 


His Pro Asp Leu Asn Val Arg Gly Gly Ala Ser Phe Val Pro Ser Glu 
145                 150                 155                 160 


Thr Asn Pro Tyr Gln Asp Gly Ser Ser His Gly Thr His Val Ala Gly 
                165                 170                 175     


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ser Pro 
            180                 185                 190         


Ser Ala Ser Leu Tyr Ala Val Lys Val Leu Asp Ser Thr Gly Ser Gly 
        195                 200                 205             


Gln Tyr Ser Trp Ile Ile Asn Gly Ile Glu Trp Ala Ile Ser Asn Asn 
    210                 215                 220                 


Met Asp Val Ile Asn Met Ser Leu Gly Gly Pro Ser Gly Ser Thr Ala 
225                 230                 235                 240 


Leu Lys Thr Val Val Asp Lys Ala Val Ser Ser Gly Ile Val Val Ala 
                245                 250                 255     


Ala Ala Ala Gly Asn Glu Gly Ser Ser Gly Ser Ser Ser Thr Val Gly 
            260                 265                 270         


Tyr Pro Ala Lys Tyr Pro Ser Thr Ile Ala Val Gly Ala Val Asn Ser 
        275                 280                 285             


Ser Asn Gln Arg Ala Ser Phe Ser Ser Ala Gly Ser Glu Leu Asp Val 
    290                 295                 300                 


Met Ala Pro Gly Val Ser Ile Gln Ser Thr Leu Pro Gly Gly Thr Tyr 
305                 310                 315                 320 


Gly Ala Tyr Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
                325                 330                 335     


Ala Ala Leu Ile Leu Ser Lys His Pro Thr Trp Thr Asn Ala Gln Val 
            340                 345                 350         


Arg Asp Arg Leu Glu Ser Thr Ala Thr Tyr Leu Gly Asn Ser Phe Tyr 
        355                 360                 365             


Tyr Gly Lys Gly Leu Ile Asn Val Gln Ala Ala Ala Gln 
    370                 375                 380     


<210>  9
<211>  381
<212>  PRT
<213>  Bacillus subtilis


<220>
<221>  MISC_FEATURE
<222>  (1)..(381)
<223>  P35835

<400>  9

Met Arg Ser Lys Lys Leu Trp Ile Ser Leu Leu Phe Ala Leu Thr Leu 
1               5                   10                  15      


Ile Phe Thr Met Ala Phe Ser Asn Met Ser Ala Gln Ala Ala Gly Lys 
            20                  25                  30          


Ser Ser Thr Glu Lys Lys Tyr Ile Val Gly Phe Lys Gln Thr Met Ser 
        35                  40                  45              


Ala Met Ser Ser Ala Lys Lys Lys Asp Val Ile Ser Glu Lys Gly Gly 
    50                  55                  60                  


Lys Val Gln Lys Gln Phe Lys Tyr Val Asn Ala Ala Ala Ala Thr Leu 
65                  70                  75                  80  


Asp Glu Lys Ala Val Lys Glu Leu Lys Lys Asp Pro Ser Val Ala Tyr 
                85                  90                  95      


Val Glu Glu Asp His Ile Ala His Glu Tyr Ala Gln Ser Val Pro Tyr 
            100                 105                 110         


Gly Ile Ser Gln Ile Lys Ala Pro Ala Leu His Ser Gln Gly Tyr Thr 
        115                 120                 125             


Gly Ser Asn Val Lys Val Ala Val Ile Asp Ser Gly Ile Asp Ser Ser 
    130                 135                 140                 


His Pro Asp Leu Asn Val Arg Gly Gly Ala Ser Phe Val Pro Ser Glu 
145                 150                 155                 160 


Thr Asn Pro Tyr Gln Asp Gly Ser Ser His Gly Thr His Val Ala Gly 
                165                 170                 175     


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro 
            180                 185                 190         


Ser Ala Ser Leu Tyr Ala Val Lys Val Leu Asp Ser Thr Gly Ser Gly 
        195                 200                 205             


Gln Tyr Ser Trp Ile Ile Asn Gly Ile Glu Trp Ala Ile Ser Asn Asn 
    210                 215                 220                 


Met Asp Val Ile Asn Met Ser Leu Gly Gly Pro Thr Gly Ser Thr Ala 
225                 230                 235                 240 


Leu Lys Thr Val Val Asp Lys Ala Val Ser Ser Gly Ile Val Val Ala 
                245                 250                 255     


Ala Ala Ala Gly Asn Glu Gly Ser Ser Gly Ser Thr Ser Thr Val Gly 
            260                 265                 270         


Tyr Pro Ala Lys Tyr Pro Ser Thr Ile Ala Val Gly Ala Val Asn Ser 
        275                 280                 285             


Ser Asn Gln Arg Ala Ser Phe Ser Ser Val Gly Ser Glu Leu Asp Val 
    290                 295                 300                 


Met Ala Pro Gly Val Ser Ile Gln Ser Thr Leu Pro Gly Gly Thr Tyr 
305                 310                 315                 320 


Gly Ala Tyr Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
                325                 330                 335     


Ala Ala Leu Ile Leu Ser Lys His Pro Thr Trp Thr Asn Ala Gln Val 
            340                 345                 350         


Arg Asp Arg Leu Glu Ser Thr Ala Thr Tyr Leu Gly Asn Ser Phe Tyr 
        355                 360                 365             


Tyr Gly Lys Gly Leu Ile Asn Val Gln Ala Ala Ala Gln 
    370                 375                 380     


<210>  10
<211>  379
<212>  PRT
<213>  Bacillus licheniformis


<220>
<221>  MISC_FEATURE
<222>  (1)..(379)
<223>  P00780

<400>  10

Met Met Arg Lys Lys Ser Phe Trp Leu Gly Met Leu Thr Ala Phe Met 
1               5                   10                  15      


Leu Val Phe Thr Met Ala Phe Ser Asp Ser Ala Ser Ala Ala Gln Pro 
            20                  25                  30          


Ala Lys Asn Val Glu Lys Asp Tyr Ile Val Gly Phe Lys Ser Gly Val 
        35                  40                  45              


Lys Thr Ala Ser Val Lys Lys Asp Ile Ile Lys Glu Ser Gly Gly Lys 
    50                  55                  60                  


Val Asp Lys Gln Phe Arg Ile Ile Asn Ala Ala Lys Ala Lys Leu Asp 
65                  70                  75                  80  


Lys Glu Ala Leu Lys Glu Val Lys Asn Asp Pro Asp Val Ala Tyr Val 
                85                  90                  95      


Glu Glu Asp His Val Ala His Ala Leu Ala Gln Thr Val Pro Tyr Gly 
            100                 105                 110         


Ile Pro Leu Ile Lys Ala Asp Lys Val Gln Ala Gln Gly Phe Lys Gly 
        115                 120                 125             


Ala Asn Val Lys Val Ala Val Leu Asp Thr Gly Ile Gln Ala Ser His 
    130                 135                 140                 


Pro Asp Leu Asn Val Val Gly Gly Ala Ser Phe Val Ala Gly Glu Ala 
145                 150                 155                 160 


Tyr Asn Thr Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Val 
                165                 170                 175     


Ala Ala Leu Asp Asn Thr Thr Gly Val Leu Gly Val Ala Pro Ser Val 
            180                 185                 190         


Ser Leu Tyr Ala Val Lys Val Leu Asn Ser Ser Gly Ser Gly Thr Tyr 
        195                 200                 205             


Ser Gly Ile Val Ser Gly Ile Glu Trp Ala Thr Thr Asn Gly Met Asp 
    210                 215                 220                 


Val Ile Asn Met Ser Leu Gly Gly Pro Ser Gly Ser Thr Ala Met Lys 
225                 230                 235                 240 


Gln Ala Val Asp Asn Ala Tyr Ala Arg Gly Val Val Val Val Ala Ala 
                245                 250                 255     


Ala Gly Asn Ser Gly Ser Ser Gly Asn Thr Asn Thr Ile Gly Tyr Pro 
            260                 265                 270         


Ala Lys Tyr Asp Ser Val Ile Ala Val Gly Ala Val Asp Ser Asn Ser 
        275                 280                 285             


Asn Arg Ala Ser Phe Ser Ser Val Gly Ala Glu Leu Glu Val Met Ala 
    290                 295                 300                 


Pro Gly Ala Gly Val Tyr Ser Thr Tyr Pro Thr Ser Thr Tyr Ala Thr 
305                 310                 315                 320 


Leu Asn Gly Thr Ser Met Ala Ser Pro His Val Ala Gly Ala Ala Ala 
                325                 330                 335     


Leu Ile Leu Ser Lys His Pro Asn Leu Ser Ala Ser Gln Val Arg Asn 
            340                 345                 350         


Arg Leu Ser Ser Thr Ala Thr Tyr Leu Gly Ser Ser Phe Tyr Tyr Gly 
        355                 360                 365             


Lys Gly Leu Ile Asn Val Glu Ala Ala Ala Gln 
    370                 375                 


<210>  11
<211>  381
<212>  PRT
<213>  Bacillus amylosacchariticus


<220>
<221>  MISC_FEATURE
<222>  (1)..(269)
<223>  P00783

<400>  11

Met Arg Ser Lys Lys Leu Trp Ile Ser Leu Leu Phe Ala Leu Thr Leu 
1               5                   10                  15      


Ile Phe Thr Met Ala Phe Ser Asn Met Ser Ala Gln Ala Ala Gly Lys 
            20                  25                  30          


Ser Ser Thr Glu Lys Lys Tyr Ile Val Gly Phe Lys Gln Thr Met Ser 
        35                  40                  45              


Ala Met Ser Ser Ala Lys Lys Lys Asp Val Ile Ser Glu Lys Gly Gly 
    50                  55                  60                  


Lys Val Gln Lys Gln Phe Lys Tyr Val Asn Ala Ala Ala Ala Thr Leu 
65                  70                  75                  80  


Asp Glu Lys Ala Val Lys Glu Leu Lys Lys Asp Pro Ser Val Ala Tyr 
                85                  90                  95      


Val Glu Glu Asp His Ile Ala His Glu Tyr Ala Gln Ser Val Pro Tyr 
            100                 105                 110         


Gly Ile Ser Gln Ile Lys Ala Pro Ala Leu His Ser Gln Gly Tyr Thr 
        115                 120                 125             


Gly Ser Asn Val Lys Val Ala Val Ile Asp Ser Gly Ile Asp Ser Ser 
    130                 135                 140                 


His Pro Asp Leu Asn Val Arg Gly Gly Ala Ser Phe Val Pro Ser Glu 
145                 150                 155                 160 


Thr Asn Pro Tyr Gln Asp Gly Ser Ser His Gly Thr His Val Ala Gly 
                165                 170                 175     


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ser Pro 
            180                 185                 190         


Ser Ala Ser Leu Tyr Ala Val Lys Val Leu Asp Ser Thr Gly Ser Gly 
        195                 200                 205             


Gln Tyr Ser Trp Ile Ile Asn Gly Ile Glu Trp Ala Ile Ser Asn Asn 
    210                 215                 220                 


Met Asp Val Ile Asn Met Ser Leu Gly Gly Pro Ser Gly Ser Thr Ala 
225                 230                 235                 240 


Leu Lys Thr Val Val Asp Lys Ala Val Ser Ser Gly Ile Val Val Ala 
                245                 250                 255     


Ala Ala Ala Gly Asn Glu Gly Ser Ser Gly Ser Ser Ser Thr Val Gly 
            260                 265                 270         


Tyr Pro Ala Lys Tyr Pro Ser Thr Ile Ala Val Gly Ala Val Asn Ser 
        275                 280                 285             


Ser Asn Gln Arg Ala Ser Phe Ser Ser Ala Gly Ser Glu Leu Asp Val 
    290                 295                 300                 


Met Ala Pro Gly Val Ser Ile Gln Ser Thr Leu Pro Gly Gly Thr Tyr 
305                 310                 315                 320 


Gly Ala Tyr Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
                325                 330                 335     


Ala Ala Leu Ile Leu Ser Lys His Pro Thr Trp Thr Asn Ala Gln Val 
            340                 345                 350         


Arg Asp Arg Leu Glu Ser Thr Ala Thr Tyr Leu Gly Asn Ser Phe Tyr 
        355                 360                 365             


Tyr Gly Lys Gly Leu Ile Asn Val Gln Ala Ala Ala Gln 
    370                 375                 380     


<210>  12
<211>  379
<212>  PRT
<213>  Bacillus licheniformis


<220>
<221>  MISC_FEATURE
<222>  (1)..(379)
<223>  Q53521

<400>  12

Met Met Arg Lys Lys Ser Phe Trp Leu Gly Met Leu Thr Ala Phe Met 
1               5                   10                  15      


Leu Val Phe Thr Met Ala Phe Ser Asp Ser Ala Ser Ala Ala Gln Pro 
            20                  25                  30          


Ala Lys Asn Val Glu Lys Asp Tyr Ile Val Gly Phe Lys Ser Gly Val 
        35                  40                  45              


Lys Thr Ala Ser Val Lys Lys Asp Ile Ile Lys Glu Ser Gly Gly Lys 
    50                  55                  60                  


Val Asp Lys Gln Phe Arg Ile Ile Asn Ala Ala Lys Ala Lys Leu Asp 
65                  70                  75                  80  


Lys Glu Ala Leu Lys Glu Val Lys Asn Asp Pro Asp Val Ala Tyr Val 
                85                  90                  95      


Glu Glu Asp His Val Ala His Ala Leu Ala Gln Thr Val Pro Tyr Gly 
            100                 105                 110         


Ile Pro Leu Ile Lys Ala Asp Lys Val Gln Ala Gln Gly Phe Lys Gly 
        115                 120                 125             


Ala Asn Val Lys Val Ala Val Leu Asp Thr Gly Ile Gln Ala Ser His 
    130                 135                 140                 


Pro Asp Leu Asn Val Val Gly Gly Ala Ser Phe Val Ala Gly Glu Ala 
145                 150                 155                 160 


Tyr Asn Thr Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Val 
                165                 170                 175     


Ala Ala Leu Asp Asn Thr Thr Gly Val Leu Gly Val Ala Pro Ser Val 
            180                 185                 190         


Ser Leu Tyr Ala Val Lys Val Leu Asn Ser Ser Gly Ser Gly Ser Tyr 
        195                 200                 205             


Ser Gly Ile Val Ser Gly Ile Glu Trp Ala Thr Thr Asn Gly Met Asp 
    210                 215                 220                 


Val Ile Asn Met Ser Leu Gly Gly Ala Ser Gly Ser Thr Ala Met Lys 
225                 230                 235                 240 


Gln Ala Val Asp Asn Ala Tyr Ala Arg Gly Val Val Val Val Ala Ala 
                245                 250                 255     


Ala Gly Asn Ser Gly Ser Ser Gly Asn Thr Asn Thr Ile Gly Tyr Pro 
            260                 265                 270         


Ala Lys Tyr Asp Ser Val Ile Ala Val Gly Ala Val Asp Ser Asn Ser 
        275                 280                 285             


Asn Arg Ala Ser Phe Ser Ser Val Gly Ala Glu Leu Glu Val Met Ala 
    290                 295                 300                 


Pro Gly Ala Gly Val Tyr Ser Thr Tyr Pro Thr Asn Thr Tyr Ala Thr 
305                 310                 315                 320 


Leu Asn Gly Thr Ser Met Val Ser Pro His Val Ala Gly Ala Ala Ala 
                325                 330                 335     


Leu Ile Leu Ser Lys His Pro Asn Leu Ser Ala Ser Gln Val Arg Asn 
            340                 345                 350         


Arg Leu Ser Ser Thr Ala Thr Tyr Leu Gly Ser Ser Phe Tyr Tyr Gly 
        355                 360                 365             


Lys Gly Leu Ile Asn Val Glu Ala Ala Ala Gln 
    370                 375                 


<210>  13
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct NI-1

<400>  13

Met Ala Gln Pro Ala Lys Asn Val Glu Lys Asp Tyr Ile Val Gly Phe 
1               5                   10                  15      


Lys Ser Gly Val Lys Thr Ala Ser Val Lys Lys Asp Ile Ile Lys Glu 
            20                  25                  30          


Ser Gly Gly Lys Val Asp Lys Gln Phe Arg Ile Ile Asn Ala Ala Lys 
        35                  40                  45              


Ala Lys Leu Asp Lys Glu Ala Leu Lys Glu Val Lys Asn Asp Pro Asp 
    50                  55                  60                  


Val Ala Tyr Val Glu Glu Asp His Val Ala His Ala Leu Ala Gln Cys 
65                  70                  75                  80  


Leu Ser Phe Gly Thr Glu Ile Leu Thr Val Glu Tyr Gly Pro Leu Pro 
                85                  90                  95      


Ile Gly Lys Ile Val Ser Glu Glu Ile Asn Cys Ser Val Tyr Ser Val 
            100                 105                 110         


Asp Pro Glu Gly Arg Val Tyr Thr Gln Ala Ile Ala Gln Trp His Asp 
        115                 120                 125             


Arg Gly Glu Gln Glu Val Leu Glu Tyr Glu Leu Glu Asp Gly Ser Val 
    130                 135                 140                 


Ile Arg Ala Thr Ser Asp His Arg Phe Leu Thr Thr Asp Tyr Gln Leu 
145                 150                 155                 160 


Leu Ala Ile Glu Glu Ile Phe Ala Arg Gln Leu Asp Leu Leu Thr Leu 
                165                 170                 175     


Glu Asn Ile Lys Gln Thr Glu Glu Ala Leu Asp Asn His Arg Leu Pro 
            180                 185                 190         


Phe Pro Leu Leu Asp Ala Gly Thr Ile Lys 
        195                 200         


<210>  14
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct IC-1

<400>  14

Met Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe 
1               5                   10                  15      


Asp Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala 
            20                  25                  30          


Ile Ala Ala Asn Cys Thr Val Pro Tyr Gly Ile Pro Leu Ile Lys Ala 
        35                  40                  45              


Asp Lys Val Gln Ala Gln Gly Phe Lys Gly Ala Asn Val Lys Val Ala 
    50                  55                  60                  


Val Leu Asp Thr Gly Ile Gln Ala Ser His Pro Asp Leu Asn Val Val 
65                  70                  75                  80  


Gly Gly Ala Ser Phe Val Ala Gly Glu Ala Tyr Asn Thr Asp Gly Asn 
                85                  90                  95      


Gly His Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr 
            100                 105                 110         


Thr Gly Val Leu Gly Val Ala Pro Ser Val Ser Leu Tyr Ala Val Lys 
        115                 120                 125             


Val Leu Asn Ser Ser Gly Ser Gly Ser Tyr Ser Gly Ile Val Ser Gly 
    130                 135                 140                 


Ile Glu Trp Ala Thr Thr Asn Gly Met Asp Val Ile Asn Met Ser Leu 
145                 150                 155                 160 


Gly Gly Ala Ser Gly Ser Thr Ala Met Lys Gln Ala Val Asp Asn Ala 
                165                 170                 175     


Tyr Ala Arg Gly Val Val Val Val Ala Ala Ala Gly Asn Ser Gly Ser 
            180                 185                 190         


Ser Gly Asn Thr Asn Thr Ile Gly Tyr Pro Ala Lys Tyr Asp Ser Val 
        195                 200                 205             


Ile Ala Val Gly Ala Val Asp Ser Asn Ser Asn Arg Ala Ser Phe Ser 
    210                 215                 220                 


Ser Val Gly Ala Glu Leu Glu Val Met Ala Pro Gly Ala Gly Val Tyr 
225                 230                 235                 240 


Ser Thr Tyr Pro Thr Asn Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met 
                245                 250                 255     


Val Ser Pro His Val Ala Gly Ala Ala Ala Leu Ile Leu Ser Lys His 
            260                 265                 270         


Pro Asn Leu Ser Ala Ser Gln Val Arg Asn Arg Leu Ser Ser Thr Ala 
        275                 280                 285             


Thr Tyr Leu Gly Ser Ser Phe Tyr Tyr Gly Lys Gly Leu Ile Asn Val 
    290                 295                 300                 


Glu Ala Ala Ala Gln 
305                 


<210>  15
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct NI-2

<400>  15

Met Ala Gln Pro Ala Lys Asn Val Glu Lys Asp Tyr Ile Val Gly Phe 
1               5                   10                  15      


Lys Ser Gly Val Lys Thr Ala Ser Val Lys Lys Asp Ile Ile Lys Glu 
            20                  25                  30          


Ser Gly Gly Lys Val Asp Lys Gln Phe Arg Ile Ile Asn Ala Ala Lys 
        35                  40                  45              


Ala Lys Leu Asp Lys Glu Ala Leu Lys Glu Val Lys Asn Asp Pro Asp 
    50                  55                  60                  


Val Ala Tyr Val Glu Glu Asp His Val Ala His Ala Leu Ala Gln Thr 
65                  70                  75                  80  


Val Pro Tyr Gly Ile Pro Leu Ile Lys Ala Asp Lys Val Gln Ala Gln 
                85                  90                  95      


Gly Phe Lys Gly Ala Asn Val Lys Val Ala Val Leu Asp Thr Gly Ile 
            100                 105                 110         


Gln Ala Ser His Pro Asp Leu Asn Val Val Gly Gly Ala Cys Leu Ser 
        115                 120                 125             


Phe Gly Thr Glu Ile Leu Thr Val Glu Tyr Gly Pro Leu Pro Ile Gly 
    130                 135                 140                 


Lys Ile Val Ser Glu Glu Ile Asn Cys Ser Val Tyr Ser Val Asp Pro 
145                 150                 155                 160 


Glu Gly Arg Val Tyr Thr Gln Ala Ile Ala Gln Trp His Asp Arg Gly 
                165                 170                 175     


Glu Gln Glu Val Leu Glu Tyr Glu Leu Glu Asp Gly Ser Val Ile Arg 
            180                 185                 190         


Ala Thr Ser Asp His Arg Phe Leu Thr Thr Asp Tyr Gln Leu Leu Ala 
        195                 200                 205             


Ile Glu Glu Ile Phe Ala Arg Gln Leu Asp Leu Leu Thr Leu Glu Asn 
    210                 215                 220                 


Ile Lys Gln Thr Glu Glu Ala Leu Asp Asn His Arg Leu Pro Phe Pro 
225                 230                 235                 240 


Leu Leu Asp Ala Gly Thr Ile Lys 
                245             


<210>  16
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct IC-2

<400>  16

Met Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe 
1               5                   10                  15      


Asp Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala 
            20                  25                  30          


Ile Ala Ala Asn Cys Ser Phe Val Ala Gly Glu Ala Tyr Asn Thr Asp 
        35                  40                  45              


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp 
    50                  55                  60                  


Asn Thr Thr Gly Val Leu Gly Val Ala Pro Ser Val Ser Leu Tyr Ala 
65                  70                  75                  80  


Val Lys Val Leu Asn Ser Ser Gly Ser Gly Ser Tyr Ser Gly Ile Val 
                85                  90                  95      


Ser Gly Ile Glu Trp Ala Thr Thr Asn Gly Met Asp Val Ile Asn Met 
            100                 105                 110         


Ser Leu Gly Gly Ala Ser Gly Ser Thr Ala Met Lys Gln Ala Val Asp 
        115                 120                 125             


Asn Ala Tyr Ala Arg Gly Val Val Val Val Ala Ala Ala Gly Asn Ser 
    130                 135                 140                 


Gly Ser Ser Gly Asn Thr Asn Thr Ile Gly Tyr Pro Ala Lys Tyr Asp 
145                 150                 155                 160 


Ser Val Ile Ala Val Gly Ala Val Asp Ser Asn Ser Asn Arg Ala Ser 
                165                 170                 175     


Phe Ser Ser Val Gly Ala Glu Leu Glu Val Met Ala Pro Gly Ala Gly 
            180                 185                 190         


Val Tyr Ser Thr Tyr Pro Thr Asn Thr Tyr Ala Thr Leu Asn Gly Thr 
        195                 200                 205             


Ser Met Val Ser Pro His Val Ala Gly Ala Ala Ala Leu Ile Leu Ser 
    210                 215                 220                 


Lys His Pro Asn Leu Ser Ala Ser Gln Val Arg Asn Arg Leu Ser Ser 
225                 230                 235                 240 


Thr Ala Thr Tyr Leu Gly Ser Ser Phe Tyr Tyr Gly Lys Gly Leu Ile 
                245                 250                 255     


Asn Val Glu Ala Ala Ala Gln 
            260             


<210>  17
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct NI-3

<400>  17

Met Ala Gln Pro Ala Lys Asn Val Glu Lys Asp Tyr Ile Val Gly Phe 
1               5                   10                  15      


Lys Ser Gly Val Lys Thr Ala Ser Val Lys Lys Asp Ile Ile Lys Glu 
            20                  25                  30          


Ser Gly Gly Lys Val Asp Lys Gln Phe Arg Ile Ile Asn Ala Ala Lys 
        35                  40                  45              


Ala Lys Leu Asp Lys Glu Ala Leu Lys Glu Val Lys Asn Asp Pro Asp 
    50                  55                  60                  


Val Ala Tyr Val Glu Glu Asp His Val Ala His Ala Leu Ala Gln Thr 
65                  70                  75                  80  


Val Pro Tyr Gly Ile Pro Leu Ile Lys Ala Asp Lys Val Gln Ala Gln 
                85                  90                  95      


Gly Phe Lys Gly Ala Asn Val Lys Val Ala Val Leu Asp Thr Gly Ile 
            100                 105                 110         


Gln Ala Ser His Pro Asp Leu Asn Val Val Gly Gly Ala Ser Phe Val 
        115                 120                 125             


Ala Gly Glu Ala Tyr Asn Thr Asp Gly Asn Gly His Gly Thr His Val 
    130                 135                 140                 


Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly Val Leu Gly Val 
145                 150                 155                 160 


Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu Asn Ser Ser Gly 
                165                 170                 175     


Ser Gly Ser Tyr Ser Gly Ile Val Ser Gly Ile Glu Trp Ala Thr Thr 
            180                 185                 190         


Asn Gly Met Asp Val Ile Asn Met Ser Leu Gly Gly Ala Cys Leu Ser 
        195                 200                 205             


Phe Gly Thr Glu Ile Leu Thr Val Glu Tyr Gly Pro Leu Pro Ile Gly 
    210                 215                 220                 


Lys Ile Val Ser Glu Glu Ile Asn Cys Ser Val Tyr Ser Val Asp Pro 
225                 230                 235                 240 


Glu Gly Arg Val Tyr Thr Gln Ala Ile Ala Gln Trp His Asp Arg Gly 
                245                 250                 255     


Glu Gln Glu Val Leu Glu Tyr Glu Leu Glu Asp Gly Ser Val Ile Arg 
            260                 265                 270         


Ala Thr Ser Asp His Arg Phe Leu Thr Thr Asp Tyr Gln Leu Leu Ala 
        275                 280                 285             


Ile Glu Glu Ile Phe Ala Arg Gln Leu Asp Leu Leu Thr Leu Glu Asn 
    290                 295                 300                 


Ile Lys Gln Thr Glu Glu Ala Leu Asp Asn His Arg Leu Pro Phe Pro 
305                 310                 315                 320 


Leu Leu Asp Ala Gly Thr Ile Lys 
                325             


<210>  18
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct IC-3

<400>  18

Met Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe 
1               5                   10                  15      


Asp Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala 
            20                  25                  30          


Ile Ala Ala Asn Cys Ser Gly Ser Thr Ala Met Lys Gln Ala Val Asp 
        35                  40                  45              


Asn Ala Tyr Ala Arg Gly Val Val Val Val Ala Ala Ala Gly Asn Ser 
    50                  55                  60                  


Gly Ser Ser Gly Asn Thr Asn Thr Ile Gly Tyr Pro Ala Lys Tyr Asp 
65                  70                  75                  80  


Ser Val Ile Ala Val Gly Ala Val Asp Ser Asn Ser Asn Arg Ala Ser 
                85                  90                  95      


Phe Ser Ser Val Gly Ala Glu Leu Glu Val Met Ala Pro Gly Ala Gly 
            100                 105                 110         


Val Tyr Ser Thr Tyr Pro Thr Asn Thr Tyr Ala Thr Leu Asn Gly Thr 
        115                 120                 125             


Ser Met Val Ser Pro His Val Ala Gly Ala Ala Ala Leu Ile Leu Ser 
    130                 135                 140                 


Lys His Pro Asn Leu Ser Ala Ser Gln Val Arg Asn Arg Leu Ser Ser 
145                 150                 155                 160 


Thr Ala Thr Tyr Leu Gly Ser Ser Phe Tyr Tyr Gly Lys Gly Leu Ile 
                165                 170                 175     


Asn Val Glu Ala Ala Ala Gln 
            180             


<210>  19
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct NI-4

<400>  19

Met Ala Gln Pro Ala Lys Asn Val Glu Lys Asp Tyr Ile Val Gly Phe 
1               5                   10                  15      


Lys Ser Gly Val Lys Thr Ala Ser Val Lys Lys Asp Ile Ile Lys Glu 
            20                  25                  30          


Ser Gly Gly Lys Val Asp Lys Gln Phe Arg Ile Ile Asn Ala Ala Lys 
        35                  40                  45              


Ala Lys Leu Asp Lys Glu Ala Leu Lys Glu Val Lys Asn Asp Pro Asp 
    50                  55                  60                  


Val Ala Tyr Val Glu Glu Asp His Val Ala His Ala Leu Ala Gln Thr 
65                  70                  75                  80  


Val Pro Tyr Gly Ile Pro Leu Ile Lys Ala Asp Lys Val Gln Ala Gln 
                85                  90                  95      


Gly Phe Lys Gly Ala Asn Val Lys Val Ala Val Leu Asp Thr Gly Ile 
            100                 105                 110         


Gln Ala Ser His Pro Asp Leu Asn Val Val Gly Gly Ala Ser Phe Val 
        115                 120                 125             


Ala Gly Glu Ala Tyr Asn Thr Asp Gly Asn Gly His Gly Thr His Val 
    130                 135                 140                 


Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly Val Leu Gly Val 
145                 150                 155                 160 


Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu Asn Ser Ser Gly 
                165                 170                 175     


Ser Gly Ser Tyr Ser Gly Ile Val Ser Gly Ile Glu Trp Ala Thr Thr 
            180                 185                 190         


Asn Gly Met Asp Val Ile Asn Met Ser Leu Gly Gly Ala Ser Gly Ser 
        195                 200                 205             


Thr Ala Met Lys Gln Ala Val Asp Asn Ala Tyr Ala Arg Gly Val Val 
    210                 215                 220                 


Val Val Ala Ala Ala Gly Asn Cys Leu Ser Phe Gly Thr Glu Ile Leu 
225                 230                 235                 240 


Thr Val Glu Tyr Gly Pro Leu Pro Ile Gly Lys Ile Val Ser Glu Glu 
                245                 250                 255     


Ile Asn Cys Ser Val Tyr Ser Val Asp Pro Glu Gly Arg Val Tyr Thr 
            260                 265                 270         


Gln Ala Ile Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Leu Glu 
        275                 280                 285             


Tyr Glu Leu Glu Asp Gly Ser Val Ile Arg Ala Thr Ser Asp His Arg 
    290                 295                 300                 


Phe Leu Thr Thr Asp Tyr Gln Leu Leu Ala Ile Glu Glu Ile Phe Ala 
305                 310                 315                 320 


Arg Gln Leu Asp Leu Leu Thr Leu Glu Asn Ile Lys Gln Thr Glu Glu 
                325                 330                 335     


Ala Leu Asp Asn His Arg Leu Pro Phe Pro Leu Leu Asp Ala Gly Thr 
            340                 345                 350         


Ile Lys 
        


<210>  20
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct IC-4

<400>  20

Met Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe 
1               5                   10                  15      


Asp Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala 
            20                  25                  30          


Ile Ala Ala Asn Cys Ser Gly Ser Ser Gly Asn Thr Asn Thr Ile Gly 
        35                  40                  45              


Tyr Pro Ala Lys Tyr Asp Ser Val Ile Ala Val Gly Ala Val Asp Ser 
    50                  55                  60                  


Asn Ser Asn Arg Ala Ser Phe Ser Ser Val Gly Ala Glu Leu Glu Val 
65                  70                  75                  80  


Met Ala Pro Gly Ala Gly Val Tyr Ser Thr Tyr Pro Thr Asn Thr Tyr 
                85                  90                  95      


Ala Thr Leu Asn Gly Thr Ser Met Val Ser Pro His Val Ala Gly Ala 
            100                 105                 110         


Ala Ala Leu Ile Leu Ser Lys His Pro Asn Leu Ser Ala Ser Gln Val 
        115                 120                 125             


Arg Asn Arg Leu Ser Ser Thr Ala Thr Tyr Leu Gly Ser Ser Phe Tyr 
    130                 135                 140                 


Tyr Gly Lys Gly Leu Ile Asn Val Glu Ala Ala Ala Gln 
145                 150                 155         


<210>  21
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct NI-5

<400>  21

Met Ala Gln Pro Ala Lys Asn Val Glu Lys Asp Tyr Ile Val Gly Phe 
1               5                   10                  15      


Lys Ser Gly Val Lys Thr Ala Ser Val Lys Lys Asp Ile Ile Lys Glu 
            20                  25                  30          


Ser Gly Gly Lys Val Asp Lys Gln Phe Arg Ile Ile Asn Ala Ala Lys 
        35                  40                  45              


Ala Lys Leu Asp Lys Glu Ala Leu Lys Glu Val Lys Asn Asp Pro Asp 
    50                  55                  60                  


Val Ala Tyr Val Glu Glu Asp His Val Ala His Ala Leu Ala Gln Thr 
65                  70                  75                  80  


Val Pro Tyr Gly Ile Pro Leu Ile Lys Ala Asp Lys Val Gln Ala Gln 
                85                  90                  95      


Gly Phe Lys Gly Ala Asn Val Lys Val Ala Val Leu Asp Thr Gly Ile 
            100                 105                 110         


Gln Ala Ser His Pro Asp Leu Asn Val Val Gly Gly Ala Ser Phe Val 
        115                 120                 125             


Ala Gly Glu Ala Tyr Asn Thr Asp Gly Asn Gly His Gly Thr His Val 
    130                 135                 140                 


Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly Val Leu Gly Val 
145                 150                 155                 160 


Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu Asn Ser Ser Gly 
                165                 170                 175     


Ser Gly Ser Tyr Ser Gly Ile Val Ser Gly Ile Glu Trp Ala Thr Thr 
            180                 185                 190         


Asn Gly Met Asp Val Ile Asn Met Ser Leu Gly Gly Ala Ser Gly Ser 
        195                 200                 205             


Thr Ala Met Lys Gln Ala Val Asp Asn Ala Tyr Ala Arg Gly Val Val 
    210                 215                 220                 


Val Val Ala Ala Ala Gly Asn Ser Gly Ser Cys Leu Ser Phe Gly Thr 
225                 230                 235                 240 


Glu Ile Leu Thr Val Glu Tyr Gly Pro Leu Pro Ile Gly Lys Ile Val 
                245                 250                 255     


Ser Glu Glu Ile Asn Cys Ser Val Tyr Ser Val Asp Pro Glu Gly Arg 
            260                 265                 270         


Val Tyr Thr Gln Ala Ile Ala Gln Trp His Asp Arg Gly Glu Gln Glu 
        275                 280                 285             


Val Leu Glu Tyr Glu Leu Glu Asp Gly Ser Val Ile Arg Ala Thr Ser 
    290                 295                 300                 


Asp His Arg Phe Leu Thr Thr Asp Tyr Gln Leu Leu Ala Ile Glu Glu 
305                 310                 315                 320 


Ile Phe Ala Arg Gln Leu Asp Leu Leu Thr Leu Glu Asn Ile Lys Gln 
                325                 330                 335     


Thr Glu Glu Ala Leu Asp Asn His Arg Leu Pro Phe Pro Leu Leu Asp 
            340                 345                 350         


Ala Gly Thr Ile Lys 
        355         


<210>  22
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct IC-5

<400>  22

Met Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe 
1               5                   10                  15      


Asp Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala 
            20                  25                  30          


Ile Ala Ala Asn Cys Ser Gly Asn Thr Asn Thr Ile Gly Tyr Pro Ala 
        35                  40                  45              


Lys Tyr Asp Ser Val Ile Ala Val Gly Ala Val Asp Ser Asn Ser Asn 
    50                  55                  60                  


Arg Ala Ser Phe Ser Ser Val Gly Ala Glu Leu Glu Val Met Ala Pro 
65                  70                  75                  80  


Gly Ala Gly Val Tyr Ser Thr Tyr Pro Thr Asn Thr Tyr Ala Thr Leu 
                85                  90                  95      


Asn Gly Thr Ser Met Val Ser Pro His Val Ala Gly Ala Ala Ala Leu 
            100                 105                 110         


Ile Leu Ser Lys His Pro Asn Leu Ser Ala Ser Gln Val Arg Asn Arg 
        115                 120                 125             


Leu Ser Ser Thr Ala Thr Tyr Leu Gly Ser Ser Phe Tyr Tyr Gly Lys 
    130                 135                 140                 


Gly Leu Ile Asn Val Glu Ala Ala Ala Gln 
145                 150                 


<210>  23
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct NI-6

<400>  23

Met Ala Gln Pro Ala Lys Asn Val Glu Lys Asp Tyr Ile Val Gly Phe 
1               5                   10                  15      


Lys Ser Gly Val Lys Thr Ala Ser Val Lys Lys Asp Ile Ile Lys Glu 
            20                  25                  30          


Ser Gly Gly Lys Val Asp Lys Gln Phe Arg Ile Ile Asn Ala Ala Lys 
        35                  40                  45              


Ala Lys Leu Asp Lys Glu Ala Leu Lys Glu Val Lys Asn Asp Pro Asp 
    50                  55                  60                  


Val Ala Tyr Val Glu Glu Asp His Val Ala His Ala Leu Ala Gln Thr 
65                  70                  75                  80  


Val Pro Tyr Gly Ile Pro Leu Ile Lys Ala Asp Lys Val Gln Ala Gln 
                85                  90                  95      


Gly Phe Lys Gly Ala Asn Val Lys Val Ala Val Leu Asp Thr Gly Ile 
            100                 105                 110         


Gln Ala Ser His Pro Asp Leu Asn Val Val Gly Gly Ala Ser Phe Val 
        115                 120                 125             


Ala Gly Glu Ala Tyr Asn Thr Asp Gly Asn Gly His Gly Thr His Val 
    130                 135                 140                 


Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly Val Leu Gly Val 
145                 150                 155                 160 


Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu Asn Ser Ser Gly 
                165                 170                 175     


Ser Gly Ser Tyr Ser Gly Ile Val Ser Gly Ile Glu Trp Ala Thr Thr 
            180                 185                 190         


Asn Gly Met Asp Val Ile Asn Met Ser Leu Gly Gly Ala Ser Gly Ser 
        195                 200                 205             


Thr Ala Met Lys Gln Ala Val Asp Asn Ala Tyr Ala Arg Gly Val Val 
    210                 215                 220                 


Val Val Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly Asn Thr Asn Thr 
225                 230                 235                 240 


Ile Gly Tyr Pro Ala Lys Tyr Asp Ser Val Ile Ala Val Gly Ala Val 
                245                 250                 255     


Asp Ser Asn Ser Asn Arg Ala Ser Phe Ser Ser Val Gly Ala Glu Leu 
            260                 265                 270         


Glu Val Met Ala Pro Gly Ala Gly Val Tyr Ser Thr Tyr Pro Thr Asn 
        275                 280                 285             


Cys Leu Ser Phe Gly Thr Glu Ile Leu Thr Val Glu Tyr Gly Pro Leu 
    290                 295                 300                 


Pro Ile Gly Lys Ile Val Ser Glu Glu Ile Asn Cys Ser Val Tyr Ser 
305                 310                 315                 320 


Val Asp Pro Glu Gly Arg Val Tyr Thr Gln Ala Ile Ala Gln Trp His 
                325                 330                 335     


Asp Arg Gly Glu Gln Glu Val Leu Glu Tyr Glu Leu Glu Asp Gly Ser 
            340                 345                 350         


Val Ile Arg Ala Thr Ser Asp His Arg Phe Leu Thr Thr Asp Tyr Gln 
        355                 360                 365             


Leu Leu Ala Ile Glu Glu Ile Phe Ala Arg Gln Leu Asp Leu Leu Thr 
    370                 375                 380                 


Leu Glu Asn Ile Lys Gln Thr Glu Glu Ala Leu Asp Asn His Arg Leu 
385                 390                 395                 400 


Pro Phe Pro Leu Leu Asp Ala Gly Thr Ile Lys 
                405                 410     


<210>  24
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct IC-6

<400>  24

Met Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe 
1               5                   10                  15      


Asp Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala 
            20                  25                  30          


Ile Ala Ala Asn Cys Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Val 
        35                  40                  45              


Ser Pro His Val Ala Gly Ala Ala Ala Leu Ile Leu Ser Lys His Pro 
    50                  55                  60                  


Asn Leu Ser Ala Ser Gln Val Arg Asn Arg Leu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Tyr Leu Gly Ser Ser Phe Tyr Tyr Gly Lys Gly Leu Ile Asn Val Glu 
                85                  90                  95      


Ala Ala Ala Gln 
            100 


<210>  25
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct VMA1

<400>  25

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Cys Phe Ala Lys Gly Thr Asn Val Leu Met Ala Asp Gly Ser Ile 
        115                 120                 125             


Glu Cys Ile Glu Asn Ile Glu Val Gly Asn Lys Val Met Gly Lys Asp 
    130                 135                 140                 


Gly Arg Pro Arg Glu Val Ile Lys Leu Pro Arg Gly Arg Glu Thr Met 
145                 150                 155                 160 


Tyr Ser Val Val Gln Lys Ser Gln His Arg Ala His Lys Ser Asp Ser 
                165                 170                 175     


Ser Arg Glu Val Pro Glu Leu Leu Lys Phe Thr Cys Asn Ala Thr His 
            180                 185                 190         


Glu Leu Val Val Arg Thr Pro Arg Ser Val Arg Arg Leu Ser Arg Thr 
        195                 200                 205             


Ile Lys Gly Val Glu Tyr Phe Glu Val Ile Thr Phe Glu Met Gly Gln 
    210                 215                 220                 


Lys Lys Ala Pro Asp Gly Arg Ile Val Glu Leu Val Lys Glu Val Ser 
225                 230                 235                 240 


Lys Ser Tyr Pro Ile Ser Glu Gly Pro Glu Arg Ala Asn Glu Leu Val 
                245                 250                 255     


Glu Ser Tyr Arg Lys Ala Ser Asn Lys Ala Tyr Phe Glu Trp Thr Ile 
            260                 265                 270         


Glu Ala Arg Asp Leu Ser Leu Leu Gly Ser His Val Arg Lys Ala Thr 
        275                 280                 285             


Tyr Gln Thr Tyr Ala Pro Ile Leu Tyr Glu Asn Asp His Phe Phe Asp 
    290                 295                 300                 


Tyr Met Gln Lys Ser Lys Phe His Leu Thr Ile Glu Gly Pro Lys Val 
305                 310                 315                 320 


Leu Ala Tyr Leu Leu Gly Leu Trp Ile Gly Asp Gly Leu Ser Asp Arg 
                325                 330                 335     


Ala Thr Phe Ser Val Asp Ser Arg Asp Thr Ser Leu Met Glu Arg Val 
            340                 345                 350         


Thr Glu Tyr Ala Glu Lys Leu Asn Leu Cys Ala Glu Tyr Lys Asp Arg 
        355                 360                 365             


Lys Glu Pro Gln Val Ala Lys Thr Val Asn Leu Tyr Ser Lys Val Val 
    370                 375                 380                 


Arg Gly Asn Gly Ile Arg Asn Asn Leu Asn Thr Glu Asn Pro Leu Trp 
385                 390                 395                 400 


Asp Ala Ile Val Gly Leu Gly Phe Leu Lys Asp Gly Val Lys Asn Ile 
                405                 410                 415     


Pro Ser Phe Leu Ser Thr Asp Asn Ile Gly Thr Arg Glu Thr Phe Leu 
            420                 425                 430         


Ala Gly Leu Ile Asp Ser Asp Gly Tyr Val Thr Asp Glu His Gly Ile 
        435                 440                 445             


Lys Ala Thr Ile Lys Thr Ile His Thr Ser Val Arg Asp Gly Leu Val 
    450                 455                 460                 


Ser Leu Ala Arg Ser Leu Gly Leu Val Val Ser Val Asn Ala Glu Pro 
465                 470                 475                 480 


Ala Lys Val Asp Met Asn Gly Thr Lys His Lys Ile Ser Tyr Ala Ile 
                485                 490                 495     


Tyr Met Ser Gly Gly Asp Val Leu Leu Asn Val Leu Ser Lys Cys Ala 
            500                 505                 510         


Gly Ser Lys Lys Phe Arg Pro Ala Pro Ala Ala Ala Phe Ala Arg Glu 
        515                 520                 525             


Cys Arg Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys Glu Asp Asp Tyr 
    530                 535                 540                 


Tyr Gly Ile Thr Leu Ser Asp Asp Ser Asp His Gln Phe Leu Leu Ala 
545                 550                 555                 560 


Asn Gln Val Val Val His Asn Ser Val Pro Trp Gly Ile Ser Arg Val 
                565                 570                 575     


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            580                 585                 590         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        595                 600                 605             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    610                 615                 620                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
625                 630                 635                 640 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                645                 650                 655     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            660                 665                 670         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        675                 680                 685             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    690                 695                 700                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
705                 710                 715                 720 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                725                 730                 735     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            740                 745                 750         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        755                 760                 765             


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
    770                 775                 780                 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
785                 790                 795                 800 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                805                 810                 815     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            820                 825                 830         


Thr Arg 
        


<210>  26
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct VMA2

<400>  26

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Cys Phe Ala Lys Gly Thr Asn Val Leu Met Ala Asp Gly 
145                 150                 155                 160 


Ser Ile Glu Cys Ile Glu Asn Ile Glu Val Gly Asn Lys Val Met Gly 
                165                 170                 175     


Lys Asp Gly Arg Pro Arg Glu Val Ile Lys Leu Pro Arg Gly Arg Glu 
            180                 185                 190         


Thr Met Tyr Ser Val Val Gln Lys Ser Gln His Arg Ala His Lys Ser 
        195                 200                 205             


Asp Ser Ser Arg Glu Val Pro Glu Leu Leu Lys Phe Thr Cys Asn Ala 
    210                 215                 220                 


Thr His Glu Leu Val Val Arg Thr Pro Arg Ser Val Arg Arg Leu Ser 
225                 230                 235                 240 


Arg Thr Ile Lys Gly Val Glu Tyr Phe Glu Val Ile Thr Phe Glu Met 
                245                 250                 255     


Gly Gln Lys Lys Ala Pro Asp Gly Arg Ile Val Glu Leu Val Lys Glu 
            260                 265                 270         


Val Ser Lys Ser Tyr Pro Ile Ser Glu Gly Pro Glu Arg Ala Asn Glu 
        275                 280                 285             


Leu Val Glu Ser Tyr Arg Lys Ala Ser Asn Lys Ala Tyr Phe Glu Trp 
    290                 295                 300                 


Thr Ile Glu Ala Arg Asp Leu Ser Leu Leu Gly Ser His Val Arg Lys 
305                 310                 315                 320 


Ala Thr Tyr Gln Thr Tyr Ala Pro Ile Leu Tyr Glu Asn Asp His Phe 
                325                 330                 335     


Phe Asp Tyr Met Gln Lys Ser Lys Phe His Leu Thr Ile Glu Gly Pro 
            340                 345                 350         


Lys Val Leu Ala Tyr Leu Leu Gly Leu Trp Ile Gly Asp Gly Leu Ser 
        355                 360                 365             


Asp Arg Ala Thr Phe Ser Val Asp Ser Arg Asp Thr Ser Leu Met Glu 
    370                 375                 380                 


Arg Val Thr Glu Tyr Ala Glu Lys Leu Asn Leu Cys Ala Glu Tyr Lys 
385                 390                 395                 400 


Asp Arg Lys Glu Pro Gln Val Ala Lys Thr Val Asn Leu Tyr Ser Lys 
                405                 410                 415     


Val Val Arg Gly Asn Gly Ile Arg Asn Asn Leu Asn Thr Glu Asn Pro 
            420                 425                 430         


Leu Trp Asp Ala Ile Val Gly Leu Gly Phe Leu Lys Asp Gly Val Lys 
        435                 440                 445             


Asn Ile Pro Ser Phe Leu Ser Thr Asp Asn Ile Gly Thr Arg Glu Thr 
    450                 455                 460                 


Phe Leu Ala Gly Leu Ile Asp Ser Asp Gly Tyr Val Thr Asp Glu His 
465                 470                 475                 480 


Gly Ile Lys Ala Thr Ile Lys Thr Ile His Thr Ser Val Arg Asp Gly 
                485                 490                 495     


Leu Val Ser Leu Ala Arg Ser Leu Gly Leu Val Val Ser Val Asn Ala 
            500                 505                 510         


Glu Pro Ala Lys Val Asp Met Asn Gly Thr Lys His Lys Ile Ser Tyr 
        515                 520                 525             


Ala Ile Tyr Met Ser Gly Gly Asp Val Leu Leu Asn Val Leu Ser Lys 
    530                 535                 540                 


Cys Ala Gly Ser Lys Lys Phe Arg Pro Ala Pro Ala Ala Ala Phe Ala 
545                 550                 555                 560 


Arg Glu Cys Arg Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys Glu Asp 
                565                 570                 575     


Asp Tyr Tyr Gly Ile Thr Leu Ser Asp Asp Ser Asp His Gln Phe Leu 
            580                 585                 590         


Leu Ala Asn Gln Val Val Val His Asn Thr His Pro Asp Leu Asn Ile 
        595                 600                 605             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    610                 615                 620                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
625                 630                 635                 640 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                645                 650                 655     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            660                 665                 670         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        675                 680                 685             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    690                 695                 700                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
705                 710                 715                 720 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                725                 730                 735     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            740                 745                 750         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        755                 760                 765             


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
    770                 775                 780                 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
785                 790                 795                 800 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                805                 810                 815     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            820                 825                 830         


Thr Arg 
        


<210>  27
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct VMA3

<400>  27

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Cys Phe Ala Lys Gly Thr Asn Val Leu Met Ala 
                165                 170                 175     


Asp Gly Ser Ile Glu Cys Ile Glu Asn Ile Glu Val Gly Asn Lys Val 
            180                 185                 190         


Met Gly Lys Asp Gly Arg Pro Arg Glu Val Ile Lys Leu Pro Arg Gly 
        195                 200                 205             


Arg Glu Thr Met Tyr Ser Val Val Gln Lys Ser Gln His Arg Ala His 
    210                 215                 220                 


Lys Ser Asp Ser Ser Arg Glu Val Pro Glu Leu Leu Lys Phe Thr Cys 
225                 230                 235                 240 


Asn Ala Thr His Glu Leu Val Val Arg Thr Pro Arg Ser Val Arg Arg 
                245                 250                 255     


Leu Ser Arg Thr Ile Lys Gly Val Glu Tyr Phe Glu Val Ile Thr Phe 
            260                 265                 270         


Glu Met Gly Gln Lys Lys Ala Pro Asp Gly Arg Ile Val Glu Leu Val 
        275                 280                 285             


Lys Glu Val Ser Lys Ser Tyr Pro Ile Ser Glu Gly Pro Glu Arg Ala 
    290                 295                 300                 


Asn Glu Leu Val Glu Ser Tyr Arg Lys Ala Ser Asn Lys Ala Tyr Phe 
305                 310                 315                 320 


Glu Trp Thr Ile Glu Ala Arg Asp Leu Ser Leu Leu Gly Ser His Val 
                325                 330                 335     


Arg Lys Ala Thr Tyr Gln Thr Tyr Ala Pro Ile Leu Tyr Glu Asn Asp 
            340                 345                 350         


His Phe Phe Asp Tyr Met Gln Lys Ser Lys Phe His Leu Thr Ile Glu 
        355                 360                 365             


Gly Pro Lys Val Leu Ala Tyr Leu Leu Gly Leu Trp Ile Gly Asp Gly 
    370                 375                 380                 


Leu Ser Asp Arg Ala Thr Phe Ser Val Asp Ser Arg Asp Thr Ser Leu 
385                 390                 395                 400 


Met Glu Arg Val Thr Glu Tyr Ala Glu Lys Leu Asn Leu Cys Ala Glu 
                405                 410                 415     


Tyr Lys Asp Arg Lys Glu Pro Gln Val Ala Lys Thr Val Asn Leu Tyr 
            420                 425                 430         


Ser Lys Val Val Arg Gly Asn Gly Ile Arg Asn Asn Leu Asn Thr Glu 
        435                 440                 445             


Asn Pro Leu Trp Asp Ala Ile Val Gly Leu Gly Phe Leu Lys Asp Gly 
    450                 455                 460                 


Val Lys Asn Ile Pro Ser Phe Leu Ser Thr Asp Asn Ile Gly Thr Arg 
465                 470                 475                 480 


Glu Thr Phe Leu Ala Gly Leu Ile Asp Ser Asp Gly Tyr Val Thr Asp 
                485                 490                 495     


Glu His Gly Ile Lys Ala Thr Ile Lys Thr Ile His Thr Ser Val Arg 
            500                 505                 510         


Asp Gly Leu Val Ser Leu Ala Arg Ser Leu Gly Leu Val Val Ser Val 
        515                 520                 525             


Asn Ala Glu Pro Ala Lys Val Asp Met Asn Gly Thr Lys His Lys Ile 
    530                 535                 540                 


Ser Tyr Ala Ile Tyr Met Ser Gly Gly Asp Val Leu Leu Asn Val Leu 
545                 550                 555                 560 


Ser Lys Cys Ala Gly Ser Lys Lys Phe Arg Pro Ala Pro Ala Ala Ala 
                565                 570                 575     


Phe Ala Arg Glu Cys Arg Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys 
            580                 585                 590         


Glu Asp Asp Tyr Tyr Gly Ile Thr Leu Ser Asp Asp Ser Asp His Gln 
        595                 600                 605             


Phe Leu Leu Ala Asn Gln Val Val Val His Asn Ser Thr Gln Asp Gly 
    610                 615                 620                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
625                 630                 635                 640 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                645                 650                 655     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            660                 665                 670         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        675                 680                 685             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    690                 695                 700                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
705                 710                 715                 720 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                725                 730                 735     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            740                 745                 750         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        755                 760                 765             


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
    770                 775                 780                 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
785                 790                 795                 800 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                805                 810                 815     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            820                 825                 830         


Thr Arg 
        


<210>  28
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct VMA4

<400>  28

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Cys Phe Ala Lys 
                245                 250                 255     


Gly Thr Asn Val Leu Met Ala Asp Gly Ser Ile Glu Cys Ile Glu Asn 
            260                 265                 270         


Ile Glu Val Gly Asn Lys Val Met Gly Lys Asp Gly Arg Pro Arg Glu 
        275                 280                 285             


Val Ile Lys Leu Pro Arg Gly Arg Glu Thr Met Tyr Ser Val Val Gln 
    290                 295                 300                 


Lys Ser Gln His Arg Ala His Lys Ser Asp Ser Ser Arg Glu Val Pro 
305                 310                 315                 320 


Glu Leu Leu Lys Phe Thr Cys Asn Ala Thr His Glu Leu Val Val Arg 
                325                 330                 335     


Thr Pro Arg Ser Val Arg Arg Leu Ser Arg Thr Ile Lys Gly Val Glu 
            340                 345                 350         


Tyr Phe Glu Val Ile Thr Phe Glu Met Gly Gln Lys Lys Ala Pro Asp 
        355                 360                 365             


Gly Arg Ile Val Glu Leu Val Lys Glu Val Ser Lys Ser Tyr Pro Ile 
    370                 375                 380                 


Ser Glu Gly Pro Glu Arg Ala Asn Glu Leu Val Glu Ser Tyr Arg Lys 
385                 390                 395                 400 


Ala Ser Asn Lys Ala Tyr Phe Glu Trp Thr Ile Glu Ala Arg Asp Leu 
                405                 410                 415     


Ser Leu Leu Gly Ser His Val Arg Lys Ala Thr Tyr Gln Thr Tyr Ala 
            420                 425                 430         


Pro Ile Leu Tyr Glu Asn Asp His Phe Phe Asp Tyr Met Gln Lys Ser 
        435                 440                 445             


Lys Phe His Leu Thr Ile Glu Gly Pro Lys Val Leu Ala Tyr Leu Leu 
    450                 455                 460                 


Gly Leu Trp Ile Gly Asp Gly Leu Ser Asp Arg Ala Thr Phe Ser Val 
465                 470                 475                 480 


Asp Ser Arg Asp Thr Ser Leu Met Glu Arg Val Thr Glu Tyr Ala Glu 
                485                 490                 495     


Lys Leu Asn Leu Cys Ala Glu Tyr Lys Asp Arg Lys Glu Pro Gln Val 
            500                 505                 510         


Ala Lys Thr Val Asn Leu Tyr Ser Lys Val Val Arg Gly Asn Gly Ile 
        515                 520                 525             


Arg Asn Asn Leu Asn Thr Glu Asn Pro Leu Trp Asp Ala Ile Val Gly 
    530                 535                 540                 


Leu Gly Phe Leu Lys Asp Gly Val Lys Asn Ile Pro Ser Phe Leu Ser 
545                 550                 555                 560 


Thr Asp Asn Ile Gly Thr Arg Glu Thr Phe Leu Ala Gly Leu Ile Asp 
                565                 570                 575     


Ser Asp Gly Tyr Val Thr Asp Glu His Gly Ile Lys Ala Thr Ile Lys 
            580                 585                 590         


Thr Ile His Thr Ser Val Arg Asp Gly Leu Val Ser Leu Ala Arg Ser 
        595                 600                 605             


Leu Gly Leu Val Val Ser Val Asn Ala Glu Pro Ala Lys Val Asp Met 
    610                 615                 620                 


Asn Gly Thr Lys His Lys Ile Ser Tyr Ala Ile Tyr Met Ser Gly Gly 
625                 630                 635                 640 


Asp Val Leu Leu Asn Val Leu Ser Lys Cys Ala Gly Ser Lys Lys Phe 
                645                 650                 655     


Arg Pro Ala Pro Ala Ala Ala Phe Ala Arg Glu Cys Arg Gly Phe Tyr 
            660                 665                 670         


Phe Glu Leu Gln Glu Leu Lys Glu Asp Asp Tyr Tyr Gly Ile Thr Leu 
        675                 680                 685             


Ser Asp Asp Ser Asp His Gln Phe Leu Leu Ala Asn Gln Val Val Val 
    690                 695                 700                 


His Asn Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
705                 710                 715                 720 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                725                 730                 735     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            740                 745                 750         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        755                 760                 765             


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
    770                 775                 780                 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
785                 790                 795                 800 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                805                 810                 815     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            820                 825                 830         


Thr Arg 
        


<210>  29
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct VMA5

<400>  29

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Cys Phe Ala Lys 
            260                 265                 270         


Gly Thr Asn Val Leu Met Ala Asp Gly Ser Ile Glu Cys Ile Glu Asn 
        275                 280                 285             


Ile Glu Val Gly Asn Lys Val Met Gly Lys Asp Gly Arg Pro Arg Glu 
    290                 295                 300                 


Val Ile Lys Leu Pro Arg Gly Arg Glu Thr Met Tyr Ser Val Val Gln 
305                 310                 315                 320 


Lys Ser Gln His Arg Ala His Lys Ser Asp Ser Ser Arg Glu Val Pro 
                325                 330                 335     


Glu Leu Leu Lys Phe Thr Cys Asn Ala Thr His Glu Leu Val Val Arg 
            340                 345                 350         


Thr Pro Arg Ser Val Arg Arg Leu Ser Arg Thr Ile Lys Gly Val Glu 
        355                 360                 365             


Tyr Phe Glu Val Ile Thr Phe Glu Met Gly Gln Lys Lys Ala Pro Asp 
    370                 375                 380                 


Gly Arg Ile Val Glu Leu Val Lys Glu Val Ser Lys Ser Tyr Pro Ile 
385                 390                 395                 400 


Ser Glu Gly Pro Glu Arg Ala Asn Glu Leu Val Glu Ser Tyr Arg Lys 
                405                 410                 415     


Ala Ser Asn Lys Ala Tyr Phe Glu Trp Thr Ile Glu Ala Arg Asp Leu 
            420                 425                 430         


Ser Leu Leu Gly Ser His Val Arg Lys Ala Thr Tyr Gln Thr Tyr Ala 
        435                 440                 445             


Pro Ile Leu Tyr Glu Asn Asp His Phe Phe Asp Tyr Met Gln Lys Ser 
    450                 455                 460                 


Lys Phe His Leu Thr Ile Glu Gly Pro Lys Val Leu Ala Tyr Leu Leu 
465                 470                 475                 480 


Gly Leu Trp Ile Gly Asp Gly Leu Ser Asp Arg Ala Thr Phe Ser Val 
                485                 490                 495     


Asp Ser Arg Asp Thr Ser Leu Met Glu Arg Val Thr Glu Tyr Ala Glu 
            500                 505                 510         


Lys Leu Asn Leu Cys Ala Glu Tyr Lys Asp Arg Lys Glu Pro Gln Val 
        515                 520                 525             


Ala Lys Thr Val Asn Leu Tyr Ser Lys Val Val Arg Gly Asn Gly Ile 
    530                 535                 540                 


Arg Asn Asn Leu Asn Thr Glu Asn Pro Leu Trp Asp Ala Ile Val Gly 
545                 550                 555                 560 


Leu Gly Phe Leu Lys Asp Gly Val Lys Asn Ile Pro Ser Phe Leu Ser 
                565                 570                 575     


Thr Asp Asn Ile Gly Thr Arg Glu Thr Phe Leu Ala Gly Leu Ile Asp 
            580                 585                 590         


Ser Asp Gly Tyr Val Thr Asp Glu His Gly Ile Lys Ala Thr Ile Lys 
        595                 600                 605             


Thr Ile His Thr Ser Val Arg Asp Gly Leu Val Ser Leu Ala Arg Ser 
    610                 615                 620                 


Leu Gly Leu Val Val Ser Val Asn Ala Glu Pro Ala Lys Val Asp Met 
625                 630                 635                 640 


Asn Gly Thr Lys His Lys Ile Ser Tyr Ala Ile Tyr Met Ser Gly Gly 
                645                 650                 655     


Asp Val Leu Leu Asn Val Leu Ser Lys Cys Ala Gly Ser Lys Lys Phe 
            660                 665                 670         


Arg Pro Ala Pro Ala Ala Ala Phe Ala Arg Glu Cys Arg Gly Phe Tyr 
        675                 680                 685             


Phe Glu Leu Gln Glu Leu Lys Glu Asp Asp Tyr Tyr Gly Ile Thr Leu 
    690                 695                 700                 


Ser Asp Asp Ser Asp His Gln Phe Leu Leu Ala Asn Gln Val Val Val 
705                 710                 715                 720 


His Asn Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                725                 730                 735     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            740                 745                 750         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        755                 760                 765             


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
    770                 775                 780                 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
785                 790                 795                 800 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                805                 810                 815     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            820                 825                 830         


Thr Arg 
        


<210>  30
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct VMA6

<400>  30

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            260                 265                 270         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        275                 280                 285             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    290                 295                 300                 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
305                 310                 315                 320 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
                325                 330                 335     


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Cys Phe Ala Lys Gly Thr 
            340                 345                 350         


Asn Val Leu Met Ala Asp Gly Ser Ile Glu Cys Ile Glu Asn Ile Glu 
        355                 360                 365             


Val Gly Asn Lys Val Met Gly Lys Asp Gly Arg Pro Arg Glu Val Ile 
    370                 375                 380                 


Lys Leu Pro Arg Gly Arg Glu Thr Met Tyr Ser Val Val Gln Lys Ser 
385                 390                 395                 400 


Gln His Arg Ala His Lys Ser Asp Ser Ser Arg Glu Val Pro Glu Leu 
                405                 410                 415     


Leu Lys Phe Thr Cys Asn Ala Thr His Glu Leu Val Val Arg Thr Pro 
            420                 425                 430         


Arg Ser Val Arg Arg Leu Ser Arg Thr Ile Lys Gly Val Glu Tyr Phe 
        435                 440                 445             


Glu Val Ile Thr Phe Glu Met Gly Gln Lys Lys Ala Pro Asp Gly Arg 
    450                 455                 460                 


Ile Val Glu Leu Val Lys Glu Val Ser Lys Ser Tyr Pro Ile Ser Glu 
465                 470                 475                 480 


Gly Pro Glu Arg Ala Asn Glu Leu Val Glu Ser Tyr Arg Lys Ala Ser 
                485                 490                 495     


Asn Lys Ala Tyr Phe Glu Trp Thr Ile Glu Ala Arg Asp Leu Ser Leu 
            500                 505                 510         


Leu Gly Ser His Val Arg Lys Ala Thr Tyr Gln Thr Tyr Ala Pro Ile 
        515                 520                 525             


Leu Tyr Glu Asn Asp His Phe Phe Asp Tyr Met Gln Lys Ser Lys Phe 
    530                 535                 540                 


His Leu Thr Ile Glu Gly Pro Lys Val Leu Ala Tyr Leu Leu Gly Leu 
545                 550                 555                 560 


Trp Ile Gly Asp Gly Leu Ser Asp Arg Ala Thr Phe Ser Val Asp Ser 
                565                 570                 575     


Arg Asp Thr Ser Leu Met Glu Arg Val Thr Glu Tyr Ala Glu Lys Leu 
            580                 585                 590         


Asn Leu Cys Ala Glu Tyr Lys Asp Arg Lys Glu Pro Gln Val Ala Lys 
        595                 600                 605             


Thr Val Asn Leu Tyr Ser Lys Val Val Arg Gly Asn Gly Ile Arg Asn 
    610                 615                 620                 


Asn Leu Asn Thr Glu Asn Pro Leu Trp Asp Ala Ile Val Gly Leu Gly 
625                 630                 635                 640 


Phe Leu Lys Asp Gly Val Lys Asn Ile Pro Ser Phe Leu Ser Thr Asp 
                645                 650                 655     


Asn Ile Gly Thr Arg Glu Thr Phe Leu Ala Gly Leu Ile Asp Ser Asp 
            660                 665                 670         


Gly Tyr Val Thr Asp Glu His Gly Ile Lys Ala Thr Ile Lys Thr Ile 
        675                 680                 685             


His Thr Ser Val Arg Asp Gly Leu Val Ser Leu Ala Arg Ser Leu Gly 
    690                 695                 700                 


Leu Val Val Ser Val Asn Ala Glu Pro Ala Lys Val Asp Met Asn Gly 
705                 710                 715                 720 


Thr Lys His Lys Ile Ser Tyr Ala Ile Tyr Met Ser Gly Gly Asp Val 
                725                 730                 735     


Leu Leu Asn Val Leu Ser Lys Cys Ala Gly Ser Lys Lys Phe Arg Pro 
            740                 745                 750         


Ala Pro Ala Ala Ala Phe Ala Arg Glu Cys Arg Gly Phe Tyr Phe Glu 
        755                 760                 765             


Leu Gln Glu Leu Lys Glu Asp Asp Tyr Tyr Gly Ile Thr Leu Ser Asp 
    770                 775                 780                 


Asp Ser Asp His Gln Phe Leu Leu Ala Asn Gln Val Val Val His Asn 
785                 790                 795                 800 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                805                 810                 815     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            820                 825                 830         


Thr Arg 
        


<210>  31
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct Tth1

<400>  31

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln 
        115                 120                 125             


Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu 
    130                 135                 140                 


Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu 
145                 150                 155                 160 


Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr 
                165                 170                 175     


Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys 
            180                 185                 190         


Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Pro Ala Glu 
        195                 200                 205             


Leu Pro Val Ala Gly His Leu Ala Pro Pro Glu Glu Arg Val Thr Leu 
    210                 215                 220                 


Leu Ala Leu Leu Leu Gly Asp Gly Asn Thr Lys Leu Ser Gly Arg Arg 
225                 230                 235                 240 


Gly Thr Arg Pro Asn Ala Phe Phe Tyr Ser Lys Asp Pro Glu Leu Leu 
                245                 250                 255     


Ala Ala Tyr Arg Arg Cys Ala Glu Ala Leu Gly Ala Lys Val Lys Ala 
            260                 265                 270         


Tyr Val His Pro Thr Thr Gly Val Val Thr Leu Ala Thr Leu Ala Pro 
        275                 280                 285             


Arg Pro Gly Ala Gln Asp Pro Val Lys Arg Leu Val Val Glu Ala Gly 
    290                 295                 300                 


Met Val Ala Lys Ala Glu Glu Lys Arg Val Pro Glu Glu Val Phe Arg 
305                 310                 315                 320 


Tyr Arg Arg Glu Ala Leu Ala Leu Phe Leu Gly Arg Leu Phe Ser Thr 
                325                 330                 335     


Asp Gly Ser Val Glu Lys Lys Arg Ile Ser Tyr Ser Ser Ala Ser Leu 
            340                 345                 350         


Gly Leu Ala Gln Asp Val Ala His Leu Leu Leu Arg Leu Gly Ile Thr 
        355                 360                 365             


Ser Gln Leu Arg Ser Arg Gly Pro Arg Ala His Glu Val Leu Ile Ser 
    370                 375                 380                 


Gly Arg Glu Asp Ile Leu Arg Phe Ala Glu Leu Ile Gly Pro Tyr Leu 
385                 390                 395                 400 


Leu Gly Ala Lys Arg Glu Arg Leu Ala Ala Leu Glu Ala Glu Ala Arg 
                405                 410                 415     


Arg Arg Leu Pro Gly Gln Gly Trp His Leu Arg Leu Val Leu Pro Ala 
            420                 425                 430         


Val Ala Tyr Arg Val Ser Glu Ala Lys Arg Arg Ser Gly Phe Ser Trp 
        435                 440                 445             


Ser Glu Ala Gly Arg Arg Val Ala Val Ala Gly Ser Cys Leu Ser Ser 
    450                 455                 460                 


Gly Leu Asn Leu Lys Leu Pro Arg Arg Tyr Leu Ser Arg His Arg Leu 
465                 470                 475                 480 


Ser Leu Leu Gly Glu Ala Phe Ala Asp Pro Gly Leu Glu Ala Leu Ala 
                485                 490                 495     


Glu Gly Gln Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro Ala Gly 
            500                 505                 510         


Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn Phe Val 
        515                 520                 525             


Ser Glu Asp Leu Val Val His Asn Ser Val Pro Trp Gly Ile Ser Arg 
    530                 535                 540                 


Val Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val 
545                 550                 555                 560 


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
                565                 570                 575     


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
            580                 585                 590         


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
        595                 600                 605             


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
    610                 615                 620                 


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
625                 630                 635                 640 


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
                645                 650                 655     


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
            660                 665                 670         


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
        675                 680                 685             


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
    690                 695                 700                 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
705                 710                 715                 720 


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
                725                 730                 735     


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            740                 745                 750         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        755                 760                 765             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    770                 775                 780                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
785                 790                 795                 800 


Ala Thr Arg 
            


<210>  32
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct Tth2

<400>  32

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr 
145                 150                 155                 160 


Gly Gln Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe 
                165                 170                 175     


Ser Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val 
            180                 185                 190         


Leu Glu Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly 
        195                 200                 205             


Arg Thr Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly 
    210                 215                 220                 


Trp Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Pro 
225                 230                 235                 240 


Ala Glu Leu Pro Val Ala Gly His Leu Ala Pro Pro Glu Glu Arg Val 
                245                 250                 255     


Thr Leu Leu Ala Leu Leu Leu Gly Asp Gly Asn Thr Lys Leu Ser Gly 
            260                 265                 270         


Arg Arg Gly Thr Arg Pro Asn Ala Phe Phe Tyr Ser Lys Asp Pro Glu 
        275                 280                 285             


Leu Leu Ala Ala Tyr Arg Arg Cys Ala Glu Ala Leu Gly Ala Lys Val 
    290                 295                 300                 


Lys Ala Tyr Val His Pro Thr Thr Gly Val Val Thr Leu Ala Thr Leu 
305                 310                 315                 320 


Ala Pro Arg Pro Gly Ala Gln Asp Pro Val Lys Arg Leu Val Val Glu 
                325                 330                 335     


Ala Gly Met Val Ala Lys Ala Glu Glu Lys Arg Val Pro Glu Glu Val 
            340                 345                 350         


Phe Arg Tyr Arg Arg Glu Ala Leu Ala Leu Phe Leu Gly Arg Leu Phe 
        355                 360                 365             


Ser Thr Asp Gly Ser Val Glu Lys Lys Arg Ile Ser Tyr Ser Ser Ala 
    370                 375                 380                 


Ser Leu Gly Leu Ala Gln Asp Val Ala His Leu Leu Leu Arg Leu Gly 
385                 390                 395                 400 


Ile Thr Ser Gln Leu Arg Ser Arg Gly Pro Arg Ala His Glu Val Leu 
                405                 410                 415     


Ile Ser Gly Arg Glu Asp Ile Leu Arg Phe Ala Glu Leu Ile Gly Pro 
            420                 425                 430         


Tyr Leu Leu Gly Ala Lys Arg Glu Arg Leu Ala Ala Leu Glu Ala Glu 
        435                 440                 445             


Ala Arg Arg Arg Leu Pro Gly Gln Gly Trp His Leu Arg Leu Val Leu 
    450                 455                 460                 


Pro Ala Val Ala Tyr Arg Val Ser Glu Ala Lys Arg Arg Ser Gly Phe 
465                 470                 475                 480 


Ser Trp Ser Glu Ala Gly Arg Arg Val Ala Val Ala Gly Ser Cys Leu 
                485                 490                 495     


Ser Ser Gly Leu Asn Leu Lys Leu Pro Arg Arg Tyr Leu Ser Arg His 
            500                 505                 510         


Arg Leu Ser Leu Leu Gly Glu Ala Phe Ala Asp Pro Gly Leu Glu Ala 
        515                 520                 525             


Leu Ala Glu Gly Gln Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro 
    530                 535                 540                 


Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn 
545                 550                 555                 560 


Phe Val Ser Glu Asp Leu Val Val His Asn Thr His Pro Asp Leu Asn 
                565                 570                 575     


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
            580                 585                 590         


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
        595                 600                 605             


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
    610                 615                 620                 


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
625                 630                 635                 640 


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
                645                 650                 655     


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
            660                 665                 670         


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
        675                 680                 685             


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
    690                 695                 700                 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
705                 710                 715                 720 


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
                725                 730                 735     


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            740                 745                 750         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        755                 760                 765             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    770                 775                 780                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
785                 790                 795                 800 


Ala Thr Arg 
            


<210>  33
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct Tth3

<400>  33

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala 
                165                 170                 175     


Ala Thr Gly Gln Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu 
            180                 185                 190         


Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu 
        195                 200                 205             


Glu Val Leu Glu Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg 
    210                 215                 220                 


Ser Gly Arg Thr Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro 
225                 230                 235                 240 


Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala 
                245                 250                 255     


Val Pro Ala Glu Leu Pro Val Ala Gly His Leu Ala Pro Pro Glu Glu 
            260                 265                 270         


Arg Val Thr Leu Leu Ala Leu Leu Leu Gly Asp Gly Asn Thr Lys Leu 
        275                 280                 285             


Ser Gly Arg Arg Gly Thr Arg Pro Asn Ala Phe Phe Tyr Ser Lys Asp 
    290                 295                 300                 


Pro Glu Leu Leu Ala Ala Tyr Arg Arg Cys Ala Glu Ala Leu Gly Ala 
305                 310                 315                 320 


Lys Val Lys Ala Tyr Val His Pro Thr Thr Gly Val Val Thr Leu Ala 
                325                 330                 335     


Thr Leu Ala Pro Arg Pro Gly Ala Gln Asp Pro Val Lys Arg Leu Val 
            340                 345                 350         


Val Glu Ala Gly Met Val Ala Lys Ala Glu Glu Lys Arg Val Pro Glu 
        355                 360                 365             


Glu Val Phe Arg Tyr Arg Arg Glu Ala Leu Ala Leu Phe Leu Gly Arg 
    370                 375                 380                 


Leu Phe Ser Thr Asp Gly Ser Val Glu Lys Lys Arg Ile Ser Tyr Ser 
385                 390                 395                 400 


Ser Ala Ser Leu Gly Leu Ala Gln Asp Val Ala His Leu Leu Leu Arg 
                405                 410                 415     


Leu Gly Ile Thr Ser Gln Leu Arg Ser Arg Gly Pro Arg Ala His Glu 
            420                 425                 430         


Val Leu Ile Ser Gly Arg Glu Asp Ile Leu Arg Phe Ala Glu Leu Ile 
        435                 440                 445             


Gly Pro Tyr Leu Leu Gly Ala Lys Arg Glu Arg Leu Ala Ala Leu Glu 
    450                 455                 460                 


Ala Glu Ala Arg Arg Arg Leu Pro Gly Gln Gly Trp His Leu Arg Leu 
465                 470                 475                 480 


Val Leu Pro Ala Val Ala Tyr Arg Val Ser Glu Ala Lys Arg Arg Ser 
                485                 490                 495     


Gly Phe Ser Trp Ser Glu Ala Gly Arg Arg Val Ala Val Ala Gly Ser 
            500                 505                 510         


Cys Leu Ser Ser Gly Leu Asn Leu Lys Leu Pro Arg Arg Tyr Leu Ser 
        515                 520                 525             


Arg His Arg Leu Ser Leu Leu Gly Glu Ala Phe Ala Asp Pro Gly Leu 
    530                 535                 540                 


Glu Ala Leu Ala Glu Gly Gln Val Leu Trp Asp Pro Ile Val Ala Val 
545                 550                 555                 560 


Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe 
                565                 570                 575     


Ala Asn Phe Val Ser Glu Asp Leu Val Val His Asn Ser Thr Gln Asp 
            580                 585                 590         


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
        595                 600                 605             


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
    610                 615                 620                 


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
625                 630                 635                 640 


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
                645                 650                 655     


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
            660                 665                 670         


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
        675                 680                 685             


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
    690                 695                 700                 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
705                 710                 715                 720 


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
                725                 730                 735     


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            740                 745                 750         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        755                 760                 765             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    770                 775                 780                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
785                 790                 795                 800 


Ala Thr Arg 
            


<210>  34
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct Tth4

<400>  34

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Cys Leu Ala Glu 
                245                 250                 255     


Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu 
            260                 265                 270         


Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg 
        275                 280                 285             


Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu 
    290                 295                 300                 


Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro 
305                 310                 315                 320 


Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu 
                325                 330                 335     


Pro Leu Gly Thr Pro Ile Ala Val Pro Ala Glu Leu Pro Val Ala Gly 
            340                 345                 350         


His Leu Ala Pro Pro Glu Glu Arg Val Thr Leu Leu Ala Leu Leu Leu 
        355                 360                 365             


Gly Asp Gly Asn Thr Lys Leu Ser Gly Arg Arg Gly Thr Arg Pro Asn 
    370                 375                 380                 


Ala Phe Phe Tyr Ser Lys Asp Pro Glu Leu Leu Ala Ala Tyr Arg Arg 
385                 390                 395                 400 


Cys Ala Glu Ala Leu Gly Ala Lys Val Lys Ala Tyr Val His Pro Thr 
                405                 410                 415     


Thr Gly Val Val Thr Leu Ala Thr Leu Ala Pro Arg Pro Gly Ala Gln 
            420                 425                 430         


Asp Pro Val Lys Arg Leu Val Val Glu Ala Gly Met Val Ala Lys Ala 
        435                 440                 445             


Glu Glu Lys Arg Val Pro Glu Glu Val Phe Arg Tyr Arg Arg Glu Ala 
    450                 455                 460                 


Leu Ala Leu Phe Leu Gly Arg Leu Phe Ser Thr Asp Gly Ser Val Glu 
465                 470                 475                 480 


Lys Lys Arg Ile Ser Tyr Ser Ser Ala Ser Leu Gly Leu Ala Gln Asp 
                485                 490                 495     


Val Ala His Leu Leu Leu Arg Leu Gly Ile Thr Ser Gln Leu Arg Ser 
            500                 505                 510         


Arg Gly Pro Arg Ala His Glu Val Leu Ile Ser Gly Arg Glu Asp Ile 
        515                 520                 525             


Leu Arg Phe Ala Glu Leu Ile Gly Pro Tyr Leu Leu Gly Ala Lys Arg 
    530                 535                 540                 


Glu Arg Leu Ala Ala Leu Glu Ala Glu Ala Arg Arg Arg Leu Pro Gly 
545                 550                 555                 560 


Gln Gly Trp His Leu Arg Leu Val Leu Pro Ala Val Ala Tyr Arg Val 
                565                 570                 575     


Ser Glu Ala Lys Arg Arg Ser Gly Phe Ser Trp Ser Glu Ala Gly Arg 
            580                 585                 590         


Arg Val Ala Val Ala Gly Ser Cys Leu Ser Ser Gly Leu Asn Leu Lys 
        595                 600                 605             


Leu Pro Arg Arg Tyr Leu Ser Arg His Arg Leu Ser Leu Leu Gly Glu 
    610                 615                 620                 


Ala Phe Ala Asp Pro Gly Leu Glu Ala Leu Ala Glu Gly Gln Val Leu 
625                 630                 635                 640 


Trp Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe 
                645                 650                 655     


Asp Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val 
            660                 665                 670         


Val His Asn Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
        675                 680                 685             


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
    690                 695                 700                 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
705                 710                 715                 720 


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
                725                 730                 735     


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            740                 745                 750         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        755                 760                 765             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    770                 775                 780                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
785                 790                 795                 800 


Ala Thr Arg 
            


<210>  35
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct Tth5

<400>  35

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Cys Leu Ala Glu 
            260                 265                 270         


Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu 
        275                 280                 285             


Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg 
    290                 295                 300                 


Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu 
305                 310                 315                 320 


Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro 
                325                 330                 335     


Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu 
            340                 345                 350         


Pro Leu Gly Thr Pro Ile Ala Val Pro Ala Glu Leu Pro Val Ala Gly 
        355                 360                 365             


His Leu Ala Pro Pro Glu Glu Arg Val Thr Leu Leu Ala Leu Leu Leu 
    370                 375                 380                 


Gly Asp Gly Asn Thr Lys Leu Ser Gly Arg Arg Gly Thr Arg Pro Asn 
385                 390                 395                 400 


Ala Phe Phe Tyr Ser Lys Asp Pro Glu Leu Leu Ala Ala Tyr Arg Arg 
                405                 410                 415     


Cys Ala Glu Ala Leu Gly Ala Lys Val Lys Ala Tyr Val His Pro Thr 
            420                 425                 430         


Thr Gly Val Val Thr Leu Ala Thr Leu Ala Pro Arg Pro Gly Ala Gln 
        435                 440                 445             


Asp Pro Val Lys Arg Leu Val Val Glu Ala Gly Met Val Ala Lys Ala 
    450                 455                 460                 


Glu Glu Lys Arg Val Pro Glu Glu Val Phe Arg Tyr Arg Arg Glu Ala 
465                 470                 475                 480 


Leu Ala Leu Phe Leu Gly Arg Leu Phe Ser Thr Asp Gly Ser Val Glu 
                485                 490                 495     


Lys Lys Arg Ile Ser Tyr Ser Ser Ala Ser Leu Gly Leu Ala Gln Asp 
            500                 505                 510         


Val Ala His Leu Leu Leu Arg Leu Gly Ile Thr Ser Gln Leu Arg Ser 
        515                 520                 525             


Arg Gly Pro Arg Ala His Glu Val Leu Ile Ser Gly Arg Glu Asp Ile 
    530                 535                 540                 


Leu Arg Phe Ala Glu Leu Ile Gly Pro Tyr Leu Leu Gly Ala Lys Arg 
545                 550                 555                 560 


Glu Arg Leu Ala Ala Leu Glu Ala Glu Ala Arg Arg Arg Leu Pro Gly 
                565                 570                 575     


Gln Gly Trp His Leu Arg Leu Val Leu Pro Ala Val Ala Tyr Arg Val 
            580                 585                 590         


Ser Glu Ala Lys Arg Arg Ser Gly Phe Ser Trp Ser Glu Ala Gly Arg 
        595                 600                 605             


Arg Val Ala Val Ala Gly Ser Cys Leu Ser Ser Gly Leu Asn Leu Lys 
    610                 615                 620                 


Leu Pro Arg Arg Tyr Leu Ser Arg His Arg Leu Ser Leu Leu Gly Glu 
625                 630                 635                 640 


Ala Phe Ala Asp Pro Gly Leu Glu Ala Leu Ala Glu Gly Gln Val Leu 
                645                 650                 655     


Trp Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe 
            660                 665                 670         


Asp Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val 
        675                 680                 685             


Val His Asn Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
    690                 695                 700                 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
705                 710                 715                 720 


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
                725                 730                 735     


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            740                 745                 750         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        755                 760                 765             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    770                 775                 780                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
785                 790                 795                 800 


Ala Thr Arg 
            


<210>  36
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct Tth6

<400>  36

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            260                 265                 270         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        275                 280                 285             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    290                 295                 300                 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
305                 310                 315                 320 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
                325                 330                 335     


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Cys Leu Ala Glu Gly Ser 
            340                 345                 350         


Leu Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys Val 
        355                 360                 365             


Arg Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr 
    370                 375                 380                 


Arg Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val Val 
385                 390                 395                 400 


Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp His 
                405                 410                 415     


Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu 
            420                 425                 430         


Gly Thr Pro Ile Ala Val Pro Ala Glu Leu Pro Val Ala Gly His Leu 
        435                 440                 445             


Ala Pro Pro Glu Glu Arg Val Thr Leu Leu Ala Leu Leu Leu Gly Asp 
    450                 455                 460                 


Gly Asn Thr Lys Leu Ser Gly Arg Arg Gly Thr Arg Pro Asn Ala Phe 
465                 470                 475                 480 


Phe Tyr Ser Lys Asp Pro Glu Leu Leu Ala Ala Tyr Arg Arg Cys Ala 
                485                 490                 495     


Glu Ala Leu Gly Ala Lys Val Lys Ala Tyr Val His Pro Thr Thr Gly 
            500                 505                 510         


Val Val Thr Leu Ala Thr Leu Ala Pro Arg Pro Gly Ala Gln Asp Pro 
        515                 520                 525             


Val Lys Arg Leu Val Val Glu Ala Gly Met Val Ala Lys Ala Glu Glu 
    530                 535                 540                 


Lys Arg Val Pro Glu Glu Val Phe Arg Tyr Arg Arg Glu Ala Leu Ala 
545                 550                 555                 560 


Leu Phe Leu Gly Arg Leu Phe Ser Thr Asp Gly Ser Val Glu Lys Lys 
                565                 570                 575     


Arg Ile Ser Tyr Ser Ser Ala Ser Leu Gly Leu Ala Gln Asp Val Ala 
            580                 585                 590         


His Leu Leu Leu Arg Leu Gly Ile Thr Ser Gln Leu Arg Ser Arg Gly 
        595                 600                 605             


Pro Arg Ala His Glu Val Leu Ile Ser Gly Arg Glu Asp Ile Leu Arg 
    610                 615                 620                 


Phe Ala Glu Leu Ile Gly Pro Tyr Leu Leu Gly Ala Lys Arg Glu Arg 
625                 630                 635                 640 


Leu Ala Ala Leu Glu Ala Glu Ala Arg Arg Arg Leu Pro Gly Gln Gly 
                645                 650                 655     


Trp His Leu Arg Leu Val Leu Pro Ala Val Ala Tyr Arg Val Ser Glu 
            660                 665                 670         


Ala Lys Arg Arg Ser Gly Phe Ser Trp Ser Glu Ala Gly Arg Arg Val 
        675                 680                 685             


Ala Val Ala Gly Ser Cys Leu Ser Ser Gly Leu Asn Leu Lys Leu Pro 
    690                 695                 700                 


Arg Arg Tyr Leu Ser Arg His Arg Leu Ser Leu Leu Gly Glu Ala Phe 
705                 710                 715                 720 


Ala Asp Pro Gly Leu Glu Ala Leu Ala Glu Gly Gln Val Leu Trp Asp 
                725                 730                 735     


Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu 
            740                 745                 750         


Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val Val His 
        755                 760                 765             


Asn Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    770                 775                 780                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
785                 790                 795                 800 


Ala Thr Arg 
            


<210>  37
<211>  454
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  misc_feature
<222>  (1)..(454)
<223>  VMA

<400>  37

Cys Phe Ala Lys Gly Thr Asn Val Leu Met Ala Asp Gly Ser Ile Glu 
1               5                   10                  15      


Cys Ile Glu Asn Ile Glu Val Gly Asn Lys Val Met Gly Lys Asp Gly 
            20                  25                  30          


Arg Pro Arg Glu Val Ile Lys Leu Pro Arg Gly Arg Glu Thr Met Tyr 
        35                  40                  45              


Ser Val Val Gln Lys Ser Gln His Arg Ala His Lys Ser Asp Ser Ser 
    50                  55                  60                  


Arg Glu Val Pro Glu Leu Leu Lys Phe Thr Cys Asn Ala Thr His Glu 
65                  70                  75                  80  


Leu Val Val Arg Thr Pro Arg Ser Val Arg Arg Leu Ser Arg Thr Ile 
                85                  90                  95      


Lys Gly Val Glu Tyr Phe Glu Val Ile Thr Phe Glu Met Gly Gln Lys 
            100                 105                 110         


Lys Ala Pro Asp Gly Arg Ile Val Glu Leu Val Lys Glu Val Ser Lys 
        115                 120                 125             


Ser Tyr Pro Ile Ser Glu Gly Pro Glu Arg Ala Asn Glu Leu Val Glu 
    130                 135                 140                 


Ser Tyr Arg Lys Ala Ser Asn Lys Ala Tyr Phe Glu Trp Thr Ile Glu 
145                 150                 155                 160 


Ala Arg Asp Leu Ser Leu Leu Gly Ser His Val Arg Lys Ala Thr Tyr 
                165                 170                 175     


Gln Thr Tyr Ala Pro Ile Leu Tyr Glu Asn Asp His Phe Phe Asp Tyr 
            180                 185                 190         


Met Gln Lys Ser Lys Phe His Leu Thr Ile Glu Gly Pro Lys Val Leu 
        195                 200                 205             


Ala Tyr Leu Leu Gly Leu Trp Ile Gly Asp Gly Leu Ser Asp Arg Ala 
    210                 215                 220                 


Thr Phe Ser Val Asp Ser Arg Asp Thr Ser Leu Met Glu Arg Val Thr 
225                 230                 235                 240 


Glu Tyr Ala Glu Lys Leu Asn Leu Cys Ala Glu Tyr Lys Asp Arg Lys 
                245                 250                 255     


Glu Pro Gln Val Ala Lys Thr Val Asn Leu Tyr Ser Lys Val Val Arg 
            260                 265                 270         


Gly Asn Gly Ile Arg Asn Asn Leu Asn Thr Glu Asn Pro Leu Trp Asp 
        275                 280                 285             


Ala Ile Val Gly Leu Gly Phe Leu Lys Asp Gly Val Lys Asn Ile Pro 
    290                 295                 300                 


Ser Phe Leu Ser Thr Asp Asn Ile Gly Thr Arg Glu Thr Phe Leu Ala 
305                 310                 315                 320 


Gly Leu Ile Asp Ser Asp Gly Tyr Val Thr Asp Glu His Gly Ile Lys 
                325                 330                 335     


Ala Thr Ile Lys Thr Ile His Thr Ser Val Arg Asp Gly Leu Val Ser 
            340                 345                 350         


Leu Ala Arg Ser Leu Gly Leu Val Val Ser Val Asn Ala Glu Pro Ala 
        355                 360                 365             


Lys Val Asp Met Asn Gly Thr Lys His Lys Ile Ser Tyr Ala Ile Tyr 
    370                 375                 380                 


Met Ser Gly Gly Asp Val Leu Leu Asn Val Leu Ser Lys Cys Ala Gly 
385                 390                 395                 400 


Ser Lys Lys Phe Arg Pro Ala Pro Ala Ala Ala Phe Ala Arg Glu Cys 
                405                 410                 415     


Arg Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys Glu Asp Asp Tyr Tyr 
            420                 425                 430         


Gly Ile Thr Leu Ser Asp Asp Ser Asp His Gln Phe Leu Leu Ala Asn 
        435                 440                 445             


Gln Val Val Val His Asn 
    450                 


<210>  38
<211>  123
<212>  PRT
<213>  Synechocystis PCC6803


<220>
<221>  misc_feature
<222>  (1)..(123)
<223>  DnaE-N

<400>  38

Cys Leu Ser Phe Gly Thr Glu Ile Leu Thr Val Glu Tyr Gly Pro Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Ser Glu Glu Ile Asn Cys Ser Val Tyr Ser 
            20                  25                  30          


Val Asp Pro Glu Gly Arg Val Tyr Thr Gln Ala Ile Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Leu Glu Tyr Glu Leu Glu Asp Gly Ser 
    50                  55                  60                  


Val Ile Arg Ala Thr Ser Asp His Arg Phe Leu Thr Thr Asp Tyr Gln 
65                  70                  75                  80  


Leu Leu Ala Ile Glu Glu Ile Phe Ala Arg Gln Leu Asp Leu Leu Thr 
                85                  90                  95      


Leu Glu Asn Ile Lys Gln Thr Glu Glu Ala Leu Asp Asn His Arg Leu 
            100                 105                 110         


Pro Phe Pro Leu Leu Asp Ala Gly Thr Ile Lys 
        115                 120             


<210>  39
<211>  36
<212>  PRT
<213>  Synechocystis PCC6803


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  DnaE-C

<400>  39

Met Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe 
1               5                   10                  15      


Asp Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala 
            20                  25                  30          


Ile Ala Ala Asn 
        35      


<210>  40
<211>  423
<212>  PRT
<213>  Thermus thermophilus


<220>
<221>  misc_feature
<222>  (1)..(423)
<223>  Tth

<400>  40

Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln Arg 
1               5                   10                  15      


Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu Gly 
            20                  25                  30          


Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu Ser 
        35                  40                  45              


Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu 
    50                  55                  60                  


Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro 
65                  70                  75                  80  


Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Pro Ala Glu Leu 
                85                  90                  95      


Pro Val Ala Gly His Leu Ala Pro Pro Glu Glu Arg Val Thr Leu Leu 
            100                 105                 110         


Ala Leu Leu Leu Gly Asp Gly Asn Thr Lys Leu Ser Gly Arg Arg Gly 
        115                 120                 125             


Thr Arg Pro Asn Ala Phe Phe Tyr Ser Lys Asp Pro Glu Leu Leu Ala 
    130                 135                 140                 


Ala Tyr Arg Arg Cys Ala Glu Ala Leu Gly Ala Lys Val Lys Ala Tyr 
145                 150                 155                 160 


Val His Pro Thr Thr Gly Val Val Thr Leu Ala Thr Leu Ala Pro Arg 
                165                 170                 175     


Pro Gly Ala Gln Asp Pro Val Lys Arg Leu Val Val Glu Ala Gly Met 
            180                 185                 190         


Val Ala Lys Ala Glu Glu Lys Arg Val Pro Glu Glu Val Phe Arg Tyr 
        195                 200                 205             


Arg Arg Glu Ala Leu Ala Leu Phe Leu Gly Arg Leu Phe Ser Thr Asp 
    210                 215                 220                 


Gly Ser Val Glu Lys Lys Arg Ile Ser Tyr Ser Ser Ala Ser Leu Gly 
225                 230                 235                 240 


Leu Ala Gln Asp Val Ala His Leu Leu Leu Arg Leu Gly Ile Thr Ser 
                245                 250                 255     


Gln Leu Arg Ser Arg Gly Pro Arg Ala His Glu Val Leu Ile Ser Gly 
            260                 265                 270         


Arg Glu Asp Ile Leu Arg Phe Ala Glu Leu Ile Gly Pro Tyr Leu Leu 
        275                 280                 285             


Gly Ala Lys Arg Glu Arg Leu Ala Ala Leu Glu Ala Glu Ala Arg Arg 
    290                 295                 300                 


Arg Leu Pro Gly Gln Gly Trp His Leu Arg Leu Val Leu Pro Ala Val 
305                 310                 315                 320 


Ala Tyr Arg Val Ser Glu Ala Lys Arg Arg Ser Gly Phe Ser Trp Ser 
                325                 330                 335     


Glu Ala Gly Arg Arg Val Ala Val Ala Gly Ser Cys Leu Ser Ser Gly 
            340                 345                 350         


Leu Asn Leu Lys Leu Pro Arg Arg Tyr Leu Ser Arg His Arg Leu Ser 
        355                 360                 365             


Leu Leu Gly Glu Ala Phe Ala Asp Pro Gly Leu Glu Ala Leu Ala Glu 
    370                 375                 380                 


Gly Gln Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys 
385                 390                 395                 400 


Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser 
                405                 410                 415     


Glu Asp Leu Val Val His Asn 
            420             


<210>  41
<211>  1140
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct Q53521 codon optimized

<400>  41
atgatgagga agaagtcctt ctggcttggc atgctgacag ccttcatgct ggtgttcacg       60

atggctttct ccgacagcgc ttctgctgct cagccagcta agaacgtgga gaaggattac      120

atcgtcggct tcaagagcgg cgtcaagaca gcttctgtta agaaggacat cattaaggag      180

agcggcggca aggttgataa gcaattcaga atcattaacg cggccaaggc taagctcgac      240

aaggaggcgc ttaaggaggt gaagaatgac ccggatgttg cctacgtgga ggaggatcac      300

gtcgcccatg ctctggcgca gactgttccg tacggcatcc cactcattaa ggccgacaag      360

gtgcaggctc aaggcttcaa gggcgcgaac gtgaaggtcg ccgttcttga caccggcatc      420

caagcttcac accctgatct gaatgtggtc ggaggagctt cgttcgtcgc tggagaggcc      480

tacaacactg acggaaatgg ccacggcacc catgtggctg gcactgtcgc tgcgcttgat      540

aacaccactg gagtcctggg cgttgctcca tcagtgtcgc tgtacgctgt gaaggtcctc      600

aactccagcg gctccggcag ctactctggc atcgtgtctg gcattgagtg ggctacaacg      660

aacggcatgg acgtcattaa tatgagcctc ggcggagctt caggatcgac cgcgatgaag      720

caggccgtcg ataacgccta cgctagaggc gttgtggtcg ttgccgctgc gggcaattcc      780

ggctcttcag gcaacaccaa tactatcggc tacccggcca agtacgactc tgtgattgct      840

gtcggcgcgg ttgattccaa cagcaatcgg gcgtcattct cgtccgttgg agctgagctc      900

gaggtcatgg ctcctggagc tggcgtgtac tccacctacc ccacaaacac gtacgcgaca      960

cttaatggca cgtcgatggt ttccccacac gtggctggag ctgctgctct gatcctcagc     1020

aagcatccaa acctgtctgc ctcacaggtc aggaatcgcc tcagctctac cgctacttac     1080

cttggctcat cgttctacta cggcaagggc ctcattaacg ttgaggccgc tgcgcaatga     1140


<210>  42
<211>  369
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct DnaE-N codon optimized

<400>  42
tgcctttctt tcggaactga gatccttacc gttgagtacg gaccacttcc tattggtaag       60

atcgtttctg aggaaattaa ctgctcagtg tactctgttg atccagaagg aagagtttac      120

actcaggcta tcgcacaatg gcacgatagg ggtgaacaag aggttctgga gtacgagctt      180

gaagatggat ccgttattcg tgctacctct gaccatagat tcttgactac agattatcag      240

cttctcgcta tcgaggaaat ctttgctagg caacttgatc tccttacttt ggagaacatc      300

aagcagacag aagaggctct tgacaaccac agacttccat tccctttgct cgatgctgga      360

accatcaag                                                              369


<210>  43
<211>  108
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct DnaE-C codon optimized

<400>  43
atggttaagg tgattggaag acgttctctt ggtgttcaaa ggatcttcga tatcggattg       60

ccacaagacc acaactttct tctcgctaat ggtgccatcg ctgccaat                   108


<210>  44
<211>  2881
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2209

<400>  44
tacagggttc cttgcgtgaa gaagggtggc ctgcggttca ccattaacgg tcacgactac       60

ttccagctag tactggtgac caacgtcgcg gcggcagggt caatcaagtc catggaggtt      120

atgggttcca acacagcgga ttggatgccg atggcacgta actggggcgc ccaatggcac      180

tcactggcct acctcaccgg tcaaggtcta tcctttaggg tcaccaacac agatgaccaa      240

acgctcgtct tcaccaacgt cgtgccacca ggatggaagt ttggccagac atttgcaagc      300

aagctgcagt tcaagtgaga ggagaagcct gaattgatac cggagcgttt cttttgggag      360

taacatctct ggttgcctag caaacatatg attgtatata agtttcgttg tgcgtttatt      420

ctttcggtgt gtaaaataac atacatgctt tcctgatatt ttcttgtata tatgtacaca      480

cacacgacaa atccttccat ttctattatt attgaacaat ttaattgcga gggcgagtac      540

ttgtctgttt accttttttt tttcagatgg cattttatag tttaaccttt catggaccgg      600

cagtagttct aaccatgaat gaaaagaaat catagtccac accacgcagg gacattgtgg      660

tcattttaga caagacgatt tgattaatgt cttgtatgat atggtcgaca gtgaggacta      720

acaaacatat ggcatatttt attaccggcg agttaaataa atttatgtca cagtaataaa      780

ctgcctaata aatgcacgcc agaaaatata atgataaaaa aaagaaaaga tacataagtc      840

cattgcttct acttttttaa aaattaaatc caacattttc tattttttgg tataaacttg      900

gaagtactag ttggatatgc aaaatcatct aacctccata tatttcatca atttgtttac      960

tttacatatg ggagaggata gtatgtcaaa gaaaatgaca acaagcttac aagtttctta     1020

ttttaaaagt tccgctaact tatcaagcat agtgtgccac gcaaaactga caacaaacca     1080

acaaatttaa ggagcgccta acttatcatc tatgacatac cgcacaaaat gataacatac     1140

tagagaaact ttattgcaca aaaggaaatt tatccataag gcaaaggaac atcttaaggc     1200

tttggatata catttaccaa caagcattgt ttgtattacc cctaaagcgc aagacatgtc     1260

atccatgagt catagtgtgt atatctcaac attgcaaagc tacctttttt ctattatact     1320

tttcgcatta taggctagat attatctata catgtcaaca aactctatcc ctacgtcata     1380

tctgaagatt cttttcttca ctatataagt tggcttccct gtcattgaac tcacatcaac     1440

cagcccaagt ttccaataac atcctcaaat agctatggcc accatcgctt tctcccgctt     1500

gtccatctac ttctgcgtgc ttctcctgtg ccacggctcc atggccgctc agccagctaa     1560

gaacgtggag aaggattaca tcgtcggctt caagagcggc gtcaagacag cttctgttaa     1620

gaaggacatc attaaggaga gcggcggcaa ggttgataag caattcagaa tcattaacgc     1680

ggccaaggct aagctcgaca aggaggcgct taaggaggtg aagaatgacc cggatgttgc     1740

ctacgtggag gaggatcacg tcgcccatgc tctggcgcag actgttccgt acggcatccc     1800

actcattaag gccgacaagg tgcaggctca aggcttcaag ggcgcgaacg tgaaggtcgc     1860

cgttcttgac accggcatcc aagcttcaca ccctgatctg aatgtggtcg gaggagcttc     1920

gttcgtcgct ggagaggcct acaacactga cggaaatggc cacggcaccc atgtggctgg     1980

cactgtcgct gcgcttgata acaccactgg agtcctgggc gttgctccat cagtgtcgct     2040

gtacgctgtg aaggtcctca actccagcgg ctccggcagc tactctggca tcgtgtctgg     2100

cattgagtgg gctacaacga acggcatgga cgtcattaat atgagcctcg gcggagcttc     2160

aggatcgacc gcgatgaagc aggccgtcga taacgcctac gctagaggcg ttgtggtcgt     2220

tgccgctgcg ggcaattccg gctcttcagg caacaccaat actatcggct acccggccaa     2280

gtacgactct gtgattgctg tcggcgcggt tgattccaac agcaatcggg cgtcattctc     2340

gtccgttgga gctgagctcg aggtcatggc tcctggagct ggcgtgtact ccacctaccc     2400

cacaaacacg tacgcgacac ttaatggcac gtcgatggtt tccccacacg tggctggagc     2460

tgctgctctg atcctcagca agcatccaaa cctgtctgcc tcacaggtca ggaatcgcct     2520

cagctctacc gctacttacc ttggctcatc gttctactac ggcaagggcc tcattaacgt     2580

tgaggccgct gcgcaatgac ctaggtcccc gaatttcccc gatcgttcaa acatttggca     2640

ataaagtttc ttaagattga atcctgttgc cggtcttgcg atgattatca tataatttct     2700

gttgaattac gttaagcatg taataattaa catgtaatgc atgacgttat ttatgagatg     2760

ggtttttatg attagagtcc cgcaattata catttaatac gcgatagaaa acaaaatata     2820

gcgcgcaaac taggataaat tatcgcgcgc ggtgtcatct atgttactag atcgggaatt     2880

g                                                                     2881


<210>  45
<211>  2899
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2210

<400>  45
tacagggttc cttgcgtgaa gaagggtggc ctgcggttca ccattaacgg tcacgactac       60

ttccagctag tactggtgac caacgtcgcg gcggcagggt caatcaagtc catggaggtt      120

atgggttcca acacagcgga ttggatgccg atggcacgta actggggcgc ccaatggcac      180

tcactggcct acctcaccgg tcaaggtcta tcctttaggg tcaccaacac agatgaccaa      240

acgctcgtct tcaccaacgt cgtgccacca ggatggaagt ttggccagac atttgcaagc      300

aagctgcagt tcaagtgaga ggagaagcct gaattgatac cggagcgttt cttttgggag      360

taacatctct ggttgcctag caaacatatg attgtatata agtttcgttg tgcgtttatt      420

ctttcggtgt gtaaaataac atacatgctt tcctgatatt ttcttgtata tatgtacaca      480

cacacgacaa atccttccat ttctattatt attgaacaat ttaattgcga gggcgagtac      540

ttgtctgttt accttttttt tttcagatgg cattttatag tttaaccttt catggaccgg      600

cagtagttct aaccatgaat gaaaagaaat catagtccac accacgcagg gacattgtgg      660

tcattttaga caagacgatt tgattaatgt cttgtatgat atggtcgaca gtgaggacta      720

acaaacatat ggcatatttt attaccggcg agttaaataa atttatgtca cagtaataaa      780

ctgcctaata aatgcacgcc agaaaatata atgataaaaa aaagaaaaga tacataagtc      840

cattgcttct acttttttaa aaattaaatc caacattttc tattttttgg tataaacttg      900

gaagtactag ttggatatgc aaaatcatct aacctccata tatttcatca atttgtttac      960

tttacatatg ggagaggata gtatgtcaaa gaaaatgaca acaagcttac aagtttctta     1020

ttttaaaagt tccgctaact tatcaagcat agtgtgccac gcaaaactga caacaaacca     1080

acaaatttaa ggagcgccta acttatcatc tatgacatac cgcacaaaat gataacatac     1140

tagagaaact ttattgcaca aaaggaaatt tatccataag gcaaaggaac atcttaaggc     1200

tttggatata catttaccaa caagcattgt ttgtattacc cctaaagcgc aagacatgtc     1260

atccatgagt catagtgtgt atatctcaac attgcaaagc tacctttttt ctattatact     1320

tttcgcatta taggctagat attatctata catgtcaaca aactctatcc ctacgtcata     1380

tctgaagatt cttttcttca ctatataagt tggcttccct gtcattgaac tcacatcaac     1440

cagcccaagt ttccaataac atcctcaaat agctatggcc accatcgctt tctcccgctt     1500

gtccatctac ttctgcgtgc ttctcctgtg ccacggctcc atggccgctc agccagctaa     1560

gaacgtggag aaggattaca tcgtcggctt caagagcggc gtcaagacag cttctgttaa     1620

gaaggacatc attaaggaga gcggcggcaa ggttgataag caattcagaa tcattaacgc     1680

ggccaaggct aagctcgaca aggaggcgct taaggaggtg aagaatgacc cggatgttgc     1740

ctacgtggag gaggatcacg tcgcccatgc tctggcgcag actgttccgt acggcatccc     1800

actcattaag gccgacaagg tgcaggctca aggcttcaag ggcgcgaacg tgaaggtcgc     1860

cgttcttgac accggcatcc aagcttcaca ccctgatctg aatgtggtcg gaggagcttc     1920

gttcgtcgct ggagaggcct acaacactga cggaaatggc cacggcaccc atgtggctgg     1980

cactgtcgct gcgcttgata acaccactgg agtcctgggc gttgctccat cagtgtcgct     2040

gtacgctgtg aaggtcctca actccagcgg ctccggcagc tactctggca tcgtgtctgg     2100

cattgagtgg gctacaacga acggcatgga cgtcattaat atgagcctcg gcggagcttc     2160

aggatcgacc gcgatgaagc aggccgtcga taacgcctac gctagaggcg ttgtggtcgt     2220

tgccgctgcg ggcaattccg gctcttcagg caacaccaat actatcggct acccggccaa     2280

gtacgactct gtgattgctg tcggcgcggt tgattccaac agcaatcggg cgtcattctc     2340

gtccgttgga gctgagctcg aggtcatggc tcctggagct ggcgtgtact ccacctaccc     2400

cacaaacacg tacgcgacac ttaatggcac gtcgatggtt tccccacacg tggctggagc     2460

tgctgctctg atcctcagca agcatccaaa cctgtctgcc tcacaggtca ggaatcgcct     2520

cagctctacc gctacttacc ttggctcatc gttctactac ggcaagggcc tcattaacgt     2580

tgaggccgct gcgcaaagcg agaaggacga gctgtgacct aggtccccga atttccccga     2640

tcgttcaaac atttggcaat aaagtttctt aagattgaat cctgttgccg gtcttgcgat     2700

gattatcata taatttctgt tgaattacgt taagcatgta ataattaaca tgtaatgcat     2760

gacgttattt atgagatggg tttttatgat tagagtcccg caattataca tttaatacgc     2820

gatagaaaac aaaatatagc gcgcaaacta ggataaatta tcgcgcgcgg tgtcatctat     2880

gttactagat cgggaattg                                                  2899


<210>  46
<211>  2887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2211

<400>  46
tacagggttc cttgcgtgaa gaagggtggc ctgcggttca ccattaacgg tcacgactac       60

ttccagctag tactggtgac caacgtcgcg gcggcagggt caatcaagtc catggaggtt      120

atgggttcca acacagcgga ttggatgccg atggcacgta actggggcgc ccaatggcac      180

tcactggcct acctcaccgg tcaaggtcta tcctttaggg tcaccaacac agatgaccaa      240

acgctcgtct tcaccaacgt cgtgccacca ggatggaagt ttggccagac atttgcaagc      300

aagctgcagt tcaagtgaga ggagaagcct gaattgatac cggagcgttt cttttgggag      360

taacatctct ggttgcctag caaacatatg attgtatata agtttcgttg tgcgtttatt      420

ctttcggtgt gtaaaataac atacatgctt tcctgatatt ttcttgtata tatgtacaca      480

cacacgacaa atccttccat ttctattatt attgaacaat ttaattgcga gggcgagtac      540

ttgtctgttt accttttttt tttcagatgg cattttatag tttaaccttt catggaccgg      600

cagtagttct aaccatgaat gaaaagaaat catagtccac accacgcagg gacattgtgg      660

tcattttaga caagacgatt tgattaatgt cttgtatgat atggtcgaca gtgaggacta      720

acaaacatat ggcatatttt attaccggcg agttaaataa atttatgtca cagtaataaa      780

ctgcctaata aatgcacgcc agaaaatata atgataaaaa aaagaaaaga tacataagtc      840

cattgcttct acttttttaa aaattaaatc caacattttc tattttttgg tataaacttg      900

gaagtactag ttggatatgc aaaatcatct aacctccata tatttcatca atttgtttac      960

tttacatatg ggagaggata gtatgtcaaa gaaaatgaca acaagcttac aagtttctta     1020

ttttaaaagt tccgctaact tatcaagcat agtgtgccac gcaaaactga caacaaacca     1080

acaaatttaa ggagcgccta acttatcatc tatgacatac cgcacaaaat gataacatac     1140

tagagaaact ttattgcaca aaaggaaatt tatccataag gcaaaggaac atcttaaggc     1200

tttggatata catttaccaa caagcattgt ttgtattacc cctaaagcgc aagacatgtc     1260

atccatgagt catagtgtgt atatctcaac attgcaaagc tacctttttt ctattatact     1320

tttcgcatta taggctagat attatctata catgtcaaca aactctatcc ctacgtcata     1380

tctgaagatt cttttcttca ctatataagt tggcttccct gtcattgaac tcacatcaac     1440

cagcccaagt ttccaataac atcctcaaat agctatggcc accatcgctt tctcccgctt     1500

gtccatctac ttctgcgtgc ttctcctgtg ccacggctcc atggcccagc tggctcagcc     1560

agctaagaac gtggagaagg attacatcgt cggcttcaag agcggcgtca agacagcttc     1620

tgttaagaag gacatcatta aggagagcgg cggcaaggtt gataagcaat tcagaatcat     1680

taacgcggcc aaggctaagc tcgacaagga ggcgcttaag gaggtgaaga atgacccgga     1740

tgttgcctac gtggaggagg atcacgtcgc ccatgctctg gcgcagactg ttccgtacgg     1800

catcccactc attaaggccg acaaggtgca ggctcaaggc ttcaagggcg cgaacgtgaa     1860

ggtcgccgtt cttgacaccg gcatccaagc ttcacaccct gatctgaatg tggtcggagg     1920

agcttcgttc gtcgctggag aggcctacaa cactgacgga aatggccacg gcacccatgt     1980

ggctggcact gtcgctgcgc ttgataacac cactggagtc ctgggcgttg ctccatcagt     2040

gtcgctgtac gctgtgaagg tcctcaactc cagcggctcc ggcagctact ctggcatcgt     2100

gtctggcatt gagtgggcta caacgaacgg catggacgtc attaatatga gcctcggcgg     2160

agcttcagga tcgaccgcga tgaagcaggc cgtcgataac gcctacgcta gaggcgttgt     2220

ggtcgttgcc gctgcgggca attccggctc ttcaggcaac accaatacta tcggctaccc     2280

ggccaagtac gactctgtga ttgctgtcgg cgcggttgat tccaacagca atcgggcgtc     2340

attctcgtcc gttggagctg agctcgaggt catggctcct ggagctggcg tgtactccac     2400

ctaccccaca aacacgtacg cgacacttaa tggcacgtcg atggtttccc cacacgtggc     2460

tggagctgct gctctgatcc tcagcaagca tccaaacctg tctgcctcac aggtcaggaa     2520

tcgcctcagc tctaccgcta cttaccttgg ctcatcgttc tactacggca agggcctcat     2580

taacgttgag gccgctgcgc aatgacctag gtccccgaat ttccccgatc gttcaaacat     2640

ttggcaataa agtttcttaa gattgaatcc tgttgccggt cttgcgatga ttatcatata     2700

atttctgttg aattacgtta agcatgtaat aattaacatg taatgcatga cgttatttat     2760

gagatgggtt tttatgatta gagtcccgca attatacatt taatacgcga tagaaaacaa     2820

aatatagcgc gcaaactagg ataaattatc gcgcgcggtg tcatctatgt tactagatcg     2880

ggaattg                                                               2887


<210>  47
<211>  2905
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2212

<400>  47
tacagggttc cttgcgtgaa gaagggtggc ctgcggttca ccattaacgg tcacgactac       60

ttccagctag tactggtgac caacgtcgcg gcggcagggt caatcaagtc catggaggtt      120

atgggttcca acacagcgga ttggatgccg atggcacgta actggggcgc ccaatggcac      180

tcactggcct acctcaccgg tcaaggtcta tcctttaggg tcaccaacac agatgaccaa      240

acgctcgtct tcaccaacgt cgtgccacca ggatggaagt ttggccagac atttgcaagc      300

aagctgcagt tcaagtgaga ggagaagcct gaattgatac cggagcgttt cttttgggag      360

taacatctct ggttgcctag caaacatatg attgtatata agtttcgttg tgcgtttatt      420

ctttcggtgt gtaaaataac atacatgctt tcctgatatt ttcttgtata tatgtacaca      480

cacacgacaa atccttccat ttctattatt attgaacaat ttaattgcga gggcgagtac      540

ttgtctgttt accttttttt tttcagatgg cattttatag tttaaccttt catggaccgg      600

cagtagttct aaccatgaat gaaaagaaat catagtccac accacgcagg gacattgtgg      660

tcattttaga caagacgatt tgattaatgt cttgtatgat atggtcgaca gtgaggacta      720

acaaacatat ggcatatttt attaccggcg agttaaataa atttatgtca cagtaataaa      780

ctgcctaata aatgcacgcc agaaaatata atgataaaaa aaagaaaaga tacataagtc      840

cattgcttct acttttttaa aaattaaatc caacattttc tattttttgg tataaacttg      900

gaagtactag ttggatatgc aaaatcatct aacctccata tatttcatca atttgtttac      960

tttacatatg ggagaggata gtatgtcaaa gaaaatgaca acaagcttac aagtttctta     1020

ttttaaaagt tccgctaact tatcaagcat agtgtgccac gcaaaactga caacaaacca     1080

acaaatttaa ggagcgccta acttatcatc tatgacatac cgcacaaaat gataacatac     1140

tagagaaact ttattgcaca aaaggaaatt tatccataag gcaaaggaac atcttaaggc     1200

tttggatata catttaccaa caagcattgt ttgtattacc cctaaagcgc aagacatgtc     1260

atccatgagt catagtgtgt atatctcaac attgcaaagc tacctttttt ctattatact     1320

tttcgcatta taggctagat attatctata catgtcaaca aactctatcc ctacgtcata     1380

tctgaagatt cttttcttca ctatataagt tggcttccct gtcattgaac tcacatcaac     1440

cagcccaagt ttccaataac atcctcaaat agctatggcc accatcgctt tctcccgctt     1500

gtccatctac ttctgcgtgc ttctcctgtg ccacggctcc atggcccagc tggctcagcc     1560

agctaagaac gtggagaagg attacatcgt cggcttcaag agcggcgtca agacagcttc     1620

tgttaagaag gacatcatta aggagagcgg cggcaaggtt gataagcaat tcagaatcat     1680

taacgcggcc aaggctaagc tcgacaagga ggcgcttaag gaggtgaaga atgacccgga     1740

tgttgcctac gtggaggagg atcacgtcgc ccatgctctg gcgcagactg ttccgtacgg     1800

catcccactc attaaggccg acaaggtgca ggctcaaggc ttcaagggcg cgaacgtgaa     1860

ggtcgccgtt cttgacaccg gcatccaagc ttcacaccct gatctgaatg tggtcggagg     1920

agcttcgttc gtcgctggag aggcctacaa cactgacgga aatggccacg gcacccatgt     1980

ggctggcact gtcgctgcgc ttgataacac cactggagtc ctgggcgttg ctccatcagt     2040

gtcgctgtac gctgtgaagg tcctcaactc cagcggctcc ggcagctact ctggcatcgt     2100

gtctggcatt gagtgggcta caacgaacgg catggacgtc attaatatga gcctcggcgg     2160

agcttcagga tcgaccgcga tgaagcaggc cgtcgataac gcctacgcta gaggcgttgt     2220

ggtcgttgcc gctgcgggca attccggctc ttcaggcaac accaatacta tcggctaccc     2280

ggccaagtac gactctgtga ttgctgtcgg cgcggttgat tccaacagca atcgggcgtc     2340

attctcgtcc gttggagctg agctcgaggt catggctcct ggagctggcg tgtactccac     2400

ctaccccaca aacacgtacg cgacacttaa tggcacgtcg atggtttccc cacacgtggc     2460

tggagctgct gctctgatcc tcagcaagca tccaaacctg tctgcctcac aggtcaggaa     2520

tcgcctcagc tctaccgcta cttaccttgg ctcatcgttc tactacggca agggcctcat     2580

taacgttgag gccgctgcgc aaagcgagaa ggacgagctg tgacctaggt ccccgaattt     2640

ccccgatcgt tcaaacattt ggcaataaag tttcttaaga ttgaatcctg ttgccggtct     2700

tgcgatgatt atcatataat ttctgttgaa ttacgttaag catgtaataa ttaacatgta     2760

atgcatgacg ttatttatga gatgggtttt tatgattaga gtcccgcaat tatacattta     2820

atacgcgata gaaaacaaaa tatagcgcgc aaactaggat aaattatcgc gcgcggtgtc     2880

atctatgtta ctagatcggg aattg                                           2905


<210>  48
<211>  3802
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2216

<400>  48
aaagtaatca tattatttta tgtgtgaatc ttctttactt tttcatttga ttatgattat       60

gaaggtatga ccttcataac cttcgtccga aatccattat atccaaagga aaataatgct      120

tcgaaggacg aaggattttg atatttaaca ttttatgttg ccttgttctt aattcatagc      180

atttgagaac aagtccccaa caccaatctt tatctttact atattaaagc accagttcaa      240

cgatcgtctc gtgtcaatat tattaaaaaa ctcctacatt tctttataat caacccgcac      300

tcttataatc tcttctctta ctactataat aagagagttt atgtacaaaa taaggtgaaa      360

ttatgtataa gtgttctgga ccttggttgt tggctcatat tcacacaacc taatcaatag      420

aaaacatatg ttttattaaa acaaaattta tcatatatat atatatatat atatatatat      480

atatatatat atataatata aaccgtagca atgcacaggc atatgactag tggcaactta      540

ataccatgtg tgtattaaga tgaataagag gtatccaaat aaataacttg ttcgcttacg      600

tctggatcga aaggggttgg aaacgattaa atctcttcct agtcaaaatt aaatagaagg      660

agatttaatc gatttctccc aatccccttc gatccaggtg caaccgaata agtccttaaa      720

tgttgaggaa cacgaaacaa ccatgcattg gcatgtaaag ctccaagaat tcgttgtatc      780

cttaacaact cacagaacat caaccaaaat tgcacgtcaa gggtattggg taagaaacaa      840

tcaaacaaat cctctctgtg tgcaaagaaa cacggtgagt catgccgaga tcatactcat      900

ctgatataca tgcttacagc tcacaagaca ttacaaacaa ctcatattgc attacaaaga      960

tcgtttcatg aaaaataaaa taggccggaa caggacaaaa atccttgacg tgtaaagtaa     1020

atttacaaca aaaaaaaagc catatgtcaa gctaaatcta attcgtttta cgtagatcaa     1080

caacctgtag aaggcaacaa aactgagcca cgcagaagta cagaatgatt ccagatgaac     1140

catcgacgtg ctacgtaaag agagtgacga gtcatataca tttggcaaga aaccatgaag     1200

ctgcctacag ccgtctcggt ggcataagaa cacaagaaat tgtgttaatt aatcaaagct     1260

ataaataacg ctcgcatgcc tgtgcacttc tccatcacca ccactgggtc ttcagaccat     1320

tagctttatc tactccagag cgcagaagaa cccgatcgac acctgttgac cattggggta     1380

tgcttgctct cctgttcatc tccgtgctaa acctctgtcc tctgggtggg tttttgctgg     1440

gattttgagc taatctgctg gccgcggtag aaaagaccgt gtcccctgat gagctcaagc     1500

gctcgcctta gccgcgtcct tgtcccccgc catttcttgc ggtttcgctg tgttcccgtg     1560

actcgccggg tgcgtcatcg cctgaatctt gtctgggctc tgctgacatg ttcttggcta     1620

gttgggttta tagattcctc tgatctaaaa ccgtgcctgt gctgcgcaca gaactctccc     1680

ctgtcctttc ctggggtttt ggttacgtgg tggtagtaag cttggatttg cacatggata     1740

aagttgttct aagctccgtg gtttgcttga gatcttgctg ttattgcgtg ccgtgctcac     1800

ttcttttgca atccgaggaa tgaatttgtc gtttactcgt tttggtggat tattagcgcg     1860

aaaaaaaact cttttttttt gttcttttac tacgaaaagc atcttcttgg attttgctat     1920

cttcttttac tacgaaaaac tcttgagtct aggaatttga atttgtgatg tccattcttg     1980

cagtgcgctg tgctttattg ggaagccaaa tcctattatt ttctgcctct agggtctgaa     2040

tggaatcagt actcttgaga caaaatcaat ccaatcaagt tgatttcttt ctttaaaaat     2100

attatcacag aactaagtgc ttgtgcggaa tcagtactgg cttttgtttg gtggaggatc     2160

aatacttgct tttgttttgg ggtggcaact gttttgctat aagattccat gtgttcctgt     2220

tgagatgaat catatatagt atagctgcat actacaaatc tgtttttcaa atttaggttg     2280

ctttggcatg atcaattttt tttcagacag tctttctaag tggtagctct tgatttcttg     2340

ttcttctaca actggtgctg ctgaatcttg accgtatagc tcgaattgca gtattctgaa     2400

ccatcgagcc atgagggtgt tgctcgttgc cctcgctctc ctggctctcg ctgcgagcgc     2460

cacctccgct cagccagcta agaacgtgga gaaggattac atcgtcggct tcaagagcgg     2520

cgtcaagaca gcttctgtta agaaggacat cattaaggag agcggcggca aggttgataa     2580

gcaattcaga atcattaacg cggccaaggc taagctcgac aaggaggcgc ttaaggaggt     2640

gaagaatgac ccggatgttg cctacgtgga ggaggatcac gtcgcccatg ctctggcgca     2700

gactgttccg tacggcatcc cactcattaa ggccgacaag gtgcaggctc aaggcttcaa     2760

gggcgcgaac gtgaaggtcg ccgttcttga caccggcatc caagcttcac accctgatct     2820

gaatgtggtc ggaggagctt cgttcgtcgc tggagaggcc tacaacactg acggaaatgg     2880

ccacggcacc catgtggctg gcactgtcgc tgcgcttgat aacaccactg gagtcctggg     2940

cgttgctcca tcagtgtcgc tgtacgctgt gaaggtcctc aactccagcg gctccggcag     3000

ctactctggc atcgtgtctg gcattgagtg ggctacaacg aacggcatgg acgtcattaa     3060

tatgagcctc ggcggagctt caggatcgac cgcgatgaag caggccgtcg ataacgccta     3120

cgctagaggc gttgtggtcg ttgccgctgc gggcaattcc ggctcttcag gcaacaccaa     3180

tactatcggc tacccggcca agtacgactc tgtgattgct gtcggcgcgg ttgattccaa     3240

cagcaatcgg gcgtcattct cgtccgttgg agctgagctc gaggtcatgg ctcctggagc     3300

tggcgtgtac tccacctacc ccacaaacac gtacgcgaca cttaatggca cgtcgatggt     3360

ttccccacac gtggctggag ctgctgctct gatcctcagc aagcatccaa acctgtctgc     3420

ctcacaggtc aggaatcgcc tcagctctac cgctacttac cttggctcat cgttctacta     3480

cggcaagggc ctcattaacg ttgaggccgc tgcgcaatga cctaggtccc cgaatttccc     3540

cgatcgttca aacatttggc aataaagttt cttaagattg aatcctgttg ccggtcttgc     3600

gatgattatc atataatttc tgttgaatta cgttaagcat gtaataatta acatgtaatg     3660

catgacgtta tttatgagat gggtttttat gattagagtc ccgcaattat acatttaata     3720

cgcgatagaa aacaaaatat agcgcgcaaa ctaggataaa ttatcgcgcg cggtgtcatc     3780

tatgttacta gatcgggaat tg                                              3802


<210>  49
<211>  3316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2217

<400>  49
aaagtaatca tattatttta tgtgtgaatc ttctttactt tttcatttga ttatgattat       60

gaaggtatga ccttcataac cttcgtccga aatccattat atccaaagga aaataatgct      120

tcgaaggacg aaggattttg atatttaaca ttttatgttg ccttgttctt aattcatagc      180

atttgagaac aagtccccaa caccaatctt tatctttact atattaaagc accagttcaa      240

cgatcgtctc gtgtcaatat tattaaaaaa ctcctacatt tctttataat caacccgcac      300

tcttataatc tcttctctta ctactataat aagagagttt atgtacaaaa taaggtgaaa      360

ttatgtataa gtgttctgga ccttggttgt tggctcatat tcacacaacc taatcaatag      420

aaaacatatg ttttattaaa acaaaattta tcatatatat atatatatat atatatatat      480

atatatatat atataatata aaccgtagca atgcacaggc atatgactag tggcaactta      540

ataccatgtg tgtattaaga tgaataagag gtatccaaat aaataacttg ttcgcttacg      600

tctggatcga aaggggttgg aaacgattaa atctcttcct agtcaaaatt aaatagaagg      660

agatttaatc gatttctccc aatccccttc gatccaggtg caaccgaata agtccttaaa      720

tgttgaggaa cacgaaacaa ccatgcattg gcatgtaaag ctccaagaat tcgttgtatc      780

cttaacaact cacagaacat caaccaaaat tgcacgtcaa gggtattggg taagaaacaa      840

tcaaacaaat cctctctgtg tgcaaagaaa cacggtgagt catgccgaga tcatactcat      900

ctgatataca tgcttacagc tcacaagaca ttacaaacaa ctcatattgc attacaaaga      960

tcgtttcatg aaaaataaaa taggccggaa caggacaaaa atccttgacg tgtaaagtaa     1020

atttacaaca aaaaaaaagc catatgtcaa gctaaatcta attcgtttta cgtagatcaa     1080

caacctgtag aaggcaacaa aactgagcca cgcagaagta cagaatgatt ccagatgaac     1140

catcgacgtg ctacgtaaag agagtgacga gtcatataca tttggcaaga aaccatgaag     1200

ctgcctacag ccgtctcggt ggcataagaa cacaagaaat tgtgttaatt aatcaaagct     1260

ataaataacg ctcgcatgcc tgtgcacttc tccatcacca ccactgggtc ttcagaccat     1320

tagctttatc tactccagag cgcagaagaa cccgatcgac acctgatcaa gtgcaaaggt     1380

ccgccttgtt tctcctctgt ctcttgatct gactaatctt ggtttatgat tcgttgagta     1440

attttgggga aagcttcgtc cacagttttt ttttcgatga acagtgccgc agtggcgctg     1500

atcttgtatg ctatcctgca atcgtggtga acttatgtct tttatatcct tcactaccat     1560

gaaaagacta gtaatctttc tcgatgtaac atcgtccagc actgctatta ccgtgtggtc     1620

catccgacag tctggctgaa cacatcatac gatattgagc aaagatctat cttccctgtt     1680

ctttaatgaa agacgtcatt ttcatcagta tgatctaaga atgttgcaac ttgcaaggag     1740

gcgtttcttt ctttgaattt aactaactcg ttgagtggcc ctgtttctcg gacgtaaggc     1800

ctttgctgct ccacacatgt ccattcgaat tttaccgtgt ttagcaaggg cgaaaagttt     1860

gcatcttgat gatttagctt gactatgcga ttgctttcct ggacccgtgc agctgcggtg     1920

gcatatgagg gtgttgctcg ttgccctcgc tctcctggct ctcgctgcga gcgccacctc     1980

cgctcagcca gctaagaacg tggagaagga ttacatcgtc ggcttcaaga gcggcgtcaa     2040

gacagcttct gttaagaagg acatcattaa ggagagcggc ggcaaggttg ataagcaatt     2100

cagaatcatt aacgcggcca aggctaagct cgacaaggag gcgcttaagg aggtgaagaa     2160

tgacccggat gttgcctacg tggaggagga tcacgtcgcc catgctctgg cgcagactgt     2220

tccgtacggc atcccactca ttaaggccga caaggtgcag gctcaaggct tcaagggcgc     2280

gaacgtgaag gtcgccgttc ttgacaccgg catccaagct tcacaccctg atctgaatgt     2340

ggtcggagga gcttcgttcg tcgctggaga ggcctacaac actgacggaa atggccacgg     2400

cacccatgtg gctggcactg tcgctgcgct tgataacacc actggagtcc tgggcgttgc     2460

tccatcagtg tcgctgtacg ctgtgaaggt cctcaactcc agcggctccg gcagctactc     2520

tggcatcgtg tctggcattg agtgggctac aacgaacggc atggacgtca ttaatatgag     2580

cctcggcgga gcttcaggat cgaccgcgat gaagcaggcc gtcgataacg cctacgctag     2640

aggcgttgtg gtcgttgccg ctgcgggcaa ttccggctct tcaggcaaca ccaatactat     2700

cggctacccg gccaagtacg actctgtgat tgctgtcggc gcggttgatt ccaacagcaa     2760

tcgggcgtca ttctcgtccg ttggagctga gctcgaggtc atggctcctg gagctggcgt     2820

gtactccacc taccccacaa acacgtacgc gacacttaat ggcacgtcga tggtttcccc     2880

acacgtggct ggagctgctg ctctgatcct cagcaagcat ccaaacctgt ctgcctcaca     2940

ggtcaggaat cgcctcagct ctaccgctac ttaccttggc tcatcgttct actacggcaa     3000

gggcctcatt aacgttgagg ccgctgcgca atgacctagg tccccgaatt tccccgatcg     3060

ttcaaacatt tggcaataaa gtttcttaag attgaatcct gttgccggtc ttgcgatgat     3120

tatcatataa tttctgttga attacgttaa gcatgtaata attaacatgt aatgcatgac     3180

gttatttatg agatgggttt ttatgattag agtcccgcaa ttatacattt aatacgcgat     3240

agaaaacaaa atatagcgcg caaactagga taaattatcg cgcgcggtgt catctatgtt     3300

actagatcgg gaattg                                                     3316


<210>  50
<211>  3791
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2218

<400>  50
aaagtaatca tattatttta tgtgtgaatc ttctttactt tttcatttga ttatgattat       60

gaaggtatga ccttcataac cttcgtccga aatccattat atccaaagga aaataatgct      120

tcgaaggacg aaggattttg atatttaaca ttttatgttg ccttgttctt aattcatagc      180

atttgagaac aagtccccaa caccaatctt tatctttact atattaaagc accagttcaa      240

cgatcgtctc gtgtcaatat tattaaaaaa ctcctacatt tctttataat caacccgcac      300

tcttataatc tcttctctta ctactataat aagagagttt atgtacaaaa taaggtgaaa      360

ttatgtataa gtgttctgga ccttggttgt tggctcatat tcacacaacc taatcaatag      420

aaaacatatg ttttattaaa acaaaattta tcatatatat atatatatat atatatatat      480

atatatatat atataatata aaccgtagca atgcacaggc atatgactag tggcaactta      540

ataccatgtg tgtattaaga tgaataagag gtatccaaat aaataacttg ttcgcttacg      600

tctggatcga aaggggttgg aaacgattaa atctcttcct agtcaaaatt aaatagaagg      660

agatttaatc gatttctccc aatccccttc gatccaggtg caaccgaata agtccttaaa      720

tgttgaggaa cacgaaacaa ccatgcattg gcatgtaaag ctccaagaat tcgttgtatc      780

cttaacaact cacagaacat caaccaaaat tgcacgtcaa gggtattggg taagaaacaa      840

tcaaacaaat cctctctgtg tgcaaagaaa cacggtgagt catgccgaga tcatactcat      900

ctgatataca tgcttacagc tcacaagaca ttacaaacaa ctcatattgc attacaaaga      960

tcgtttcatg aaaaataaaa taggccggaa caggacaaaa atccttgacg tgtaaagtaa     1020

atttacaaca aaaaaaaagc catatgtcaa gctaaatcta attcgtttta cgtagatcaa     1080

caacctgtag aaggcaacaa aactgagcca cgcagaagta cagaatgatt ccagatgaac     1140

catcgacgtg ctacgtaaag agagtgacga gtcatataca tttggcaaga aaccatgaag     1200

ctgcctacag ccgtctcggt ggcataagaa cacaagaaat tgtgttaatt aatcaaagct     1260

ataaataacg ctcgcatgcc tgtgcacttc tccatcacca ccactgggtc ttcagaccat     1320

tagctttatc tactccagag cgcagaagaa cccgatcgac acctccgctt caaggtacgc     1380

cgctcgtcct cccccccccc ccctctctac cttctctaga tcggcgttcc ggtccatggt     1440

tagggcccgg tagttctact tctgttcatg tttgtgttag atccgtgttt gtgttagatc     1500

cgtgctgcta gcgttcgtac acggatgcga cctgtacgtc agacacgttc tgattgctaa     1560

cttgccagtg tttctctttg gggaatcctg ggatggctct agccgttccg cagacgggat     1620

cgatttcatg attttttttg tttcgttgca tagggtttgg tttgcccttt tcctttattt     1680

caatatatgc cgtgcacttg tttgtcgggt catcttttca tgcttttttt tgtcttggtt     1740

gtgatgatgt ggtctggttg ggcggtcgtt ctagatcgga gtagaattct gtttcaaact     1800

acctggtgga tttattaatt ttggatctgt atgtgtgtgc catacatatt catagttacg     1860

aattgaagat gatggatgga aatatcgatc taggataggt atacatgttg atgcgggttt     1920

tactgatgca tatacagaga tgctttttgt tcgcttggtt gtgatgatgt ggtgtggttg     1980

ggcggtcgtt cattcgttct agatcggagt agaatactgt ttcaaactac ctggtgtatt     2040

tattaatttt ggaactgtat gtgtgtgtca tacatcttca tagttacgag tttaagatgg     2100

atggaaatat cgatctagga taggtataca tgttgatgtg ggttttactg atgcatatac     2160

atgatggcat atgcagcatc tattcatatg ctctaacctt gagtacctat ctattataat     2220

aaacaagtat gttttataat tattttgatc ttgatatact tggatgatgg catatgcagc     2280

agctatatgt ggattttttt agccctgcct tcatacgcta tttatttgct tggtactgtt     2340

tcttttgtcg atgctcaccc tgttgtttgg tgttacttct gcagatccag atctttgtga     2400

tgagggtgtt gctcgttgcc ctcgctctcc tggctctcgc tgcgagcgcc acctccgctc     2460

agccagctaa gaacgtggag aaggattaca tcgtcggctt caagagcggc gtcaagacag     2520

cttctgttaa gaaggacatc attaaggaga gcggcggcaa ggttgataag caattcagaa     2580

tcattaacgc ggccaaggct aagctcgaca aggaggcgct taaggaggtg aagaatgacc     2640

cggatgttgc ctacgtggag gaggatcacg tcgcccatgc tctggcgcag actgttccgt     2700

acggcatccc actcattaag gccgacaagg tgcaggctca aggcttcaag ggcgcgaacg     2760

tgaaggtcgc cgttcttgac accggcatcc aagcttcaca ccctgatctg aatgtggtcg     2820

gaggagcttc gttcgtcgct ggagaggcct acaacactga cggaaatggc cacggcaccc     2880

atgtggctgg cactgtcgct gcgcttgata acaccactgg agtcctgggc gttgctccat     2940

cagtgtcgct gtacgctgtg aaggtcctca actccagcgg ctccggcagc tactctggca     3000

tcgtgtctgg cattgagtgg gctacaacga acggcatgga cgtcattaat atgagcctcg     3060

gcggagcttc aggatcgacc gcgatgaagc aggccgtcga taacgcctac gctagaggcg     3120

ttgtggtcgt tgccgctgcg ggcaattccg gctcttcagg caacaccaat actatcggct     3180

acccggccaa gtacgactct gtgattgctg tcggcgcggt tgattccaac agcaatcggg     3240

cgtcattctc gtccgttgga gctgagctcg aggtcatggc tcctggagct ggcgtgtact     3300

ccacctaccc cacaaacacg tacgcgacac ttaatggcac gtcgatggtt tccccacacg     3360

tggctggagc tgctgctctg atcctcagca agcatccaaa cctgtctgcc tcacaggtca     3420

ggaatcgcct cagctctacc gctacttacc ttggctcatc gttctactac ggcaagggcc     3480

tcattaacgt tgaggccgct gcgcaatgac ctaggtcccc gaatttcccc gatcgttcaa     3540

acatttggca ataaagtttc ttaagattga atcctgttgc cggtcttgcg atgattatca     3600

tataatttct gttgaattac gttaagcatg taataattaa catgtaatgc atgacgttat     3660

ttatgagatg ggtttttatg attagagtcc cgcaattata catttaatac gcgatagaaa     3720

acaaaatata gcgcgcaaac taggataaat tatcgcgcgc ggtgtcatct atgttactag     3780

atcgggaatt g                                                          3791


<210>  51
<211>  3820
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2219

<400>  51
aaagtaatca tattatttta tgtgtgaatc ttctttactt tttcatttga ttatgattat       60

gaaggtatga ccttcataac cttcgtccga aatccattat atccaaagga aaataatgct      120

tcgaaggacg aaggattttg atatttaaca ttttatgttg ccttgttctt aattcatagc      180

atttgagaac aagtccccaa caccaatctt tatctttact atattaaagc accagttcaa      240

cgatcgtctc gtgtcaatat tattaaaaaa ctcctacatt tctttataat caacccgcac      300

tcttataatc tcttctctta ctactataat aagagagttt atgtacaaaa taaggtgaaa      360

ttatgtataa gtgttctgga ccttggttgt tggctcatat tcacacaacc taatcaatag      420

aaaacatatg ttttattaaa acaaaattta tcatatatat atatatatat atatatatat      480

atatatatat atataatata aaccgtagca atgcacaggc atatgactag tggcaactta      540

ataccatgtg tgtattaaga tgaataagag gtatccaaat aaataacttg ttcgcttacg      600

tctggatcga aaggggttgg aaacgattaa atctcttcct agtcaaaatt aaatagaagg      660

agatttaatc gatttctccc aatccccttc gatccaggtg caaccgaata agtccttaaa      720

tgttgaggaa cacgaaacaa ccatgcattg gcatgtaaag ctccaagaat tcgttgtatc      780

cttaacaact cacagaacat caaccaaaat tgcacgtcaa gggtattggg taagaaacaa      840

tcaaacaaat cctctctgtg tgcaaagaaa cacggtgagt catgccgaga tcatactcat      900

ctgatataca tgcttacagc tcacaagaca ttacaaacaa ctcatattgc attacaaaga      960

tcgtttcatg aaaaataaaa taggccggaa caggacaaaa atccttgacg tgtaaagtaa     1020

atttacaaca aaaaaaaagc catatgtcaa gctaaatcta attcgtttta cgtagatcaa     1080

caacctgtag aaggcaacaa aactgagcca cgcagaagta cagaatgatt ccagatgaac     1140

catcgacgtg ctacgtaaag agagtgacga gtcatataca tttggcaaga aaccatgaag     1200

ctgcctacag ccgtctcggt ggcataagaa cacaagaaat tgtgttaatt aatcaaagct     1260

ataaataacg ctcgcatgcc tgtgcacttc tccatcacca ccactgggtc ttcagaccat     1320

tagctttatc tactccagag cgcagaagaa cccgatcgac acctgttgac cattggggta     1380

tgcttgctct cctgttcatc tccgtgctaa acctctgtcc tctgggtggg tttttgctgg     1440

gattttgagc taatctgctg gccgcggtag aaaagaccgt gtcccctgat gagctcaagc     1500

gctcgcctta gccgcgtcct tgtcccccgc catttcttgc ggtttcgctg tgttcccgtg     1560

actcgccggg tgcgtcatcg cctgaatctt gtctgggctc tgctgacatg ttcttggcta     1620

gttgggttta tagattcctc tgatctaaaa ccgtgcctgt gctgcgcaca gaactctccc     1680

ctgtcctttc ctggggtttt ggttacgtgg tggtagtaag cttggatttg cacatggata     1740

aagttgttct aagctccgtg gtttgcttga gatcttgctg ttattgcgtg ccgtgctcac     1800

ttcttttgca atccgaggaa tgaatttgtc gtttactcgt tttggtggat tattagcgcg     1860

aaaaaaaact cttttttttt gttcttttac tacgaaaagc atcttcttgg attttgctat     1920

cttcttttac tacgaaaaac tcttgagtct aggaatttga atttgtgatg tccattcttg     1980

cagtgcgctg tgctttattg ggaagccaaa tcctattatt ttctgcctct agggtctgaa     2040

tggaatcagt actcttgaga caaaatcaat ccaatcaagt tgatttcttt ctttaaaaat     2100

attatcacag aactaagtgc ttgtgcggaa tcagtactgg cttttgtttg gtggaggatc     2160

aatacttgct tttgttttgg ggtggcaact gttttgctat aagattccat gtgttcctgt     2220

tgagatgaat catatatagt atagctgcat actacaaatc tgtttttcaa atttaggttg     2280

ctttggcatg atcaattttt tttcagacag tctttctaag tggtagctct tgatttcttg     2340

ttcttctaca actggtgctg ctgaatcttg accgtatagc tcgaattgca gtattctgaa     2400

ccatcgagcc atgagggtgt tgctcgttgc cctcgctctc ctggctctcg ctgcgagcgc     2460

cacctccgct cagccagcta agaacgtgga gaaggattac atcgtcggct tcaagagcgg     2520

cgtcaagaca gcttctgtta agaaggacat cattaaggag agcggcggca aggttgataa     2580

gcaattcaga atcattaacg cggccaaggc taagctcgac aaggaggcgc ttaaggaggt     2640

gaagaatgac ccggatgttg cctacgtgga ggaggatcac gtcgcccatg ctctggcgca     2700

gactgttccg tacggcatcc cactcattaa ggccgacaag gtgcaggctc aaggcttcaa     2760

gggcgcgaac gtgaaggtcg ccgttcttga caccggcatc caagcttcac accctgatct     2820

gaatgtggtc ggaggagctt cgttcgtcgc tggagaggcc tacaacactg acggaaatgg     2880

ccacggcacc catgtggctg gcactgtcgc tgcgcttgat aacaccactg gagtcctggg     2940

cgttgctcca tcagtgtcgc tgtacgctgt gaaggtcctc aactccagcg gctccggcag     3000

ctactctggc atcgtgtctg gcattgagtg ggctacaacg aacggcatgg acgtcattaa     3060

tatgagcctc ggcggagctt caggatcgac cgcgatgaag caggccgtcg ataacgccta     3120

cgctagaggc gttgtggtcg ttgccgctgc gggcaattcc ggctcttcag gcaacaccaa     3180

tactatcggc tacccggcca agtacgactc tgtgattgct gtcggcgcgg ttgattccaa     3240

cagcaatcgg gcgtcattct cgtccgttgg agctgagctc gaggtcatgg ctcctggagc     3300

tggcgtgtac tccacctacc ccacaaacac gtacgcgaca cttaatggca cgtcgatggt     3360

ttccccacac gtggctggag ctgctgctct gatcctcagc aagcatccaa acctgtctgc     3420

ctcacaggtc aggaatcgcc tcagctctac cgctacttac cttggctcat cgttctacta     3480

cggcaagggc ctcattaacg ttgaggccgc tgcgcaaagc gagaaggacg agctgtgacc     3540

taggtccccg aatttccccg atcgttcaaa catttggcaa taaagtttct taagattgaa     3600

tcctgttgcc ggtcttgcga tgattatcat ataatttctg ttgaattacg ttaagcatgt     3660

aataattaac atgtaatgca tgacgttatt tatgagatgg gtttttatga ttagagtccc     3720

gcaattatac atttaatacg cgatagaaaa caaaatatag cgcgcaaact aggataaatt     3780

atcgcgcgcg gtgtcatcta tgttactaga tcgggaattg                           3820


<210>  52
<211>  3334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2220

<400>  52
aaagtaatca tattatttta tgtgtgaatc ttctttactt tttcatttga ttatgattat       60

gaaggtatga ccttcataac cttcgtccga aatccattat atccaaagga aaataatgct      120

tcgaaggacg aaggattttg atatttaaca ttttatgttg ccttgttctt aattcatagc      180

atttgagaac aagtccccaa caccaatctt tatctttact atattaaagc accagttcaa      240

cgatcgtctc gtgtcaatat tattaaaaaa ctcctacatt tctttataat caacccgcac      300

tcttataatc tcttctctta ctactataat aagagagttt atgtacaaaa taaggtgaaa      360

ttatgtataa gtgttctgga ccttggttgt tggctcatat tcacacaacc taatcaatag      420

aaaacatatg ttttattaaa acaaaattta tcatatatat atatatatat atatatatat      480

atatatatat atataatata aaccgtagca atgcacaggc atatgactag tggcaactta      540

ataccatgtg tgtattaaga tgaataagag gtatccaaat aaataacttg ttcgcttacg      600

tctggatcga aaggggttgg aaacgattaa atctcttcct agtcaaaatt aaatagaagg      660

agatttaatc gatttctccc aatccccttc gatccaggtg caaccgaata agtccttaaa      720

tgttgaggaa cacgaaacaa ccatgcattg gcatgtaaag ctccaagaat tcgttgtatc      780

cttaacaact cacagaacat caaccaaaat tgcacgtcaa gggtattggg taagaaacaa      840

tcaaacaaat cctctctgtg tgcaaagaaa cacggtgagt catgccgaga tcatactcat      900

ctgatataca tgcttacagc tcacaagaca ttacaaacaa ctcatattgc attacaaaga      960

tcgtttcatg aaaaataaaa taggccggaa caggacaaaa atccttgacg tgtaaagtaa     1020

atttacaaca aaaaaaaagc catatgtcaa gctaaatcta attcgtttta cgtagatcaa     1080

caacctgtag aaggcaacaa aactgagcca cgcagaagta cagaatgatt ccagatgaac     1140

catcgacgtg ctacgtaaag agagtgacga gtcatataca tttggcaaga aaccatgaag     1200

ctgcctacag ccgtctcggt ggcataagaa cacaagaaat tgtgttaatt aatcaaagct     1260

ataaataacg ctcgcatgcc tgtgcacttc tccatcacca ccactgggtc ttcagaccat     1320

tagctttatc tactccagag cgcagaagaa cccgatcgac acctgatcaa gtgcaaaggt     1380

ccgccttgtt tctcctctgt ctcttgatct gactaatctt ggtttatgat tcgttgagta     1440

attttgggga aagcttcgtc cacagttttt ttttcgatga acagtgccgc agtggcgctg     1500

atcttgtatg ctatcctgca atcgtggtga acttatgtct tttatatcct tcactaccat     1560

gaaaagacta gtaatctttc tcgatgtaac atcgtccagc actgctatta ccgtgtggtc     1620

catccgacag tctggctgaa cacatcatac gatattgagc aaagatctat cttccctgtt     1680

ctttaatgaa agacgtcatt ttcatcagta tgatctaaga atgttgcaac ttgcaaggag     1740

gcgtttcttt ctttgaattt aactaactcg ttgagtggcc ctgtttctcg gacgtaaggc     1800

ctttgctgct ccacacatgt ccattcgaat tttaccgtgt ttagcaaggg cgaaaagttt     1860

gcatcttgat gatttagctt gactatgcga ttgctttcct ggacccgtgc agctgcggtg     1920

gcatatgagg gtgttgctcg ttgccctcgc tctcctggct ctcgctgcga gcgccacctc     1980

cgctcagcca gctaagaacg tggagaagga ttacatcgtc ggcttcaaga gcggcgtcaa     2040

gacagcttct gttaagaagg acatcattaa ggagagcggc ggcaaggttg ataagcaatt     2100

cagaatcatt aacgcggcca aggctaagct cgacaaggag gcgcttaagg aggtgaagaa     2160

tgacccggat gttgcctacg tggaggagga tcacgtcgcc catgctctgg cgcagactgt     2220

tccgtacggc atcccactca ttaaggccga caaggtgcag gctcaaggct tcaagggcgc     2280

gaacgtgaag gtcgccgttc ttgacaccgg catccaagct tcacaccctg atctgaatgt     2340

ggtcggagga gcttcgttcg tcgctggaga ggcctacaac actgacggaa atggccacgg     2400

cacccatgtg gctggcactg tcgctgcgct tgataacacc actggagtcc tgggcgttgc     2460

tccatcagtg tcgctgtacg ctgtgaaggt cctcaactcc agcggctccg gcagctactc     2520

tggcatcgtg tctggcattg agtgggctac aacgaacggc atggacgtca ttaatatgag     2580

cctcggcgga gcttcaggat cgaccgcgat gaagcaggcc gtcgataacg cctacgctag     2640

aggcgttgtg gtcgttgccg ctgcgggcaa ttccggctct tcaggcaaca ccaatactat     2700

cggctacccg gccaagtacg actctgtgat tgctgtcggc gcggttgatt ccaacagcaa     2760

tcgggcgtca ttctcgtccg ttggagctga gctcgaggtc atggctcctg gagctggcgt     2820

gtactccacc taccccacaa acacgtacgc gacacttaat ggcacgtcga tggtttcccc     2880

acacgtggct ggagctgctg ctctgatcct cagcaagcat ccaaacctgt ctgcctcaca     2940

ggtcaggaat cgcctcagct ctaccgctac ttaccttggc tcatcgttct actacggcaa     3000

gggcctcatt aacgttgagg ccgctgcgca aagcgagaag gacgagctgt gacctaggtc     3060

cccgaatttc cccgatcgtt caaacatttg gcaataaagt ttcttaagat tgaatcctgt     3120

tgccggtctt gcgatgatta tcatataatt tctgttgaat tacgttaagc atgtaataat     3180

taacatgtaa tgcatgacgt tatttatgag atgggttttt atgattagag tcccgcaatt     3240

atacatttaa tacgcgatag aaaacaaaat atagcgcgca aactaggata aattatcgcg     3300

cgcggtgtca tctatgttac tagatcggga attg                                 3334


<210>  53
<211>  3809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2221

<400>  53
aaagtaatca tattatttta tgtgtgaatc ttctttactt tttcatttga ttatgattat       60

gaaggtatga ccttcataac cttcgtccga aatccattat atccaaagga aaataatgct      120

tcgaaggacg aaggattttg atatttaaca ttttatgttg ccttgttctt aattcatagc      180

atttgagaac aagtccccaa caccaatctt tatctttact atattaaagc accagttcaa      240

cgatcgtctc gtgtcaatat tattaaaaaa ctcctacatt tctttataat caacccgcac      300

tcttataatc tcttctctta ctactataat aagagagttt atgtacaaaa taaggtgaaa      360

ttatgtataa gtgttctgga ccttggttgt tggctcatat tcacacaacc taatcaatag      420

aaaacatatg ttttattaaa acaaaattta tcatatatat atatatatat atatatatat      480

atatatatat atataatata aaccgtagca atgcacaggc atatgactag tggcaactta      540

ataccatgtg tgtattaaga tgaataagag gtatccaaat aaataacttg ttcgcttacg      600

tctggatcga aaggggttgg aaacgattaa atctcttcct agtcaaaatt aaatagaagg      660

agatttaatc gatttctccc aatccccttc gatccaggtg caaccgaata agtccttaaa      720

tgttgaggaa cacgaaacaa ccatgcattg gcatgtaaag ctccaagaat tcgttgtatc      780

cttaacaact cacagaacat caaccaaaat tgcacgtcaa gggtattggg taagaaacaa      840

tcaaacaaat cctctctgtg tgcaaagaaa cacggtgagt catgccgaga tcatactcat      900

ctgatataca tgcttacagc tcacaagaca ttacaaacaa ctcatattgc attacaaaga      960

tcgtttcatg aaaaataaaa taggccggaa caggacaaaa atccttgacg tgtaaagtaa     1020

atttacaaca aaaaaaaagc catatgtcaa gctaaatcta attcgtttta cgtagatcaa     1080

caacctgtag aaggcaacaa aactgagcca cgcagaagta cagaatgatt ccagatgaac     1140

catcgacgtg ctacgtaaag agagtgacga gtcatataca tttggcaaga aaccatgaag     1200

ctgcctacag ccgtctcggt ggcataagaa cacaagaaat tgtgttaatt aatcaaagct     1260

ataaataacg ctcgcatgcc tgtgcacttc tccatcacca ccactgggtc ttcagaccat     1320

tagctttatc tactccagag cgcagaagaa cccgatcgac acctccgctt caaggtacgc     1380

cgctcgtcct cccccccccc ccctctctac cttctctaga tcggcgttcc ggtccatggt     1440

tagggcccgg tagttctact tctgttcatg tttgtgttag atccgtgttt gtgttagatc     1500

cgtgctgcta gcgttcgtac acggatgcga cctgtacgtc agacacgttc tgattgctaa     1560

cttgccagtg tttctctttg gggaatcctg ggatggctct agccgttccg cagacgggat     1620

cgatttcatg attttttttg tttcgttgca tagggtttgg tttgcccttt tcctttattt     1680

caatatatgc cgtgcacttg tttgtcgggt catcttttca tgcttttttt tgtcttggtt     1740

gtgatgatgt ggtctggttg ggcggtcgtt ctagatcgga gtagaattct gtttcaaact     1800

acctggtgga tttattaatt ttggatctgt atgtgtgtgc catacatatt catagttacg     1860

aattgaagat gatggatgga aatatcgatc taggataggt atacatgttg atgcgggttt     1920

tactgatgca tatacagaga tgctttttgt tcgcttggtt gtgatgatgt ggtgtggttg     1980

ggcggtcgtt cattcgttct agatcggagt agaatactgt ttcaaactac ctggtgtatt     2040

tattaatttt ggaactgtat gtgtgtgtca tacatcttca tagttacgag tttaagatgg     2100

atggaaatat cgatctagga taggtataca tgttgatgtg ggttttactg atgcatatac     2160

atgatggcat atgcagcatc tattcatatg ctctaacctt gagtacctat ctattataat     2220

aaacaagtat gttttataat tattttgatc ttgatatact tggatgatgg catatgcagc     2280

agctatatgt ggattttttt agccctgcct tcatacgcta tttatttgct tggtactgtt     2340

tcttttgtcg atgctcaccc tgttgtttgg tgttacttct gcagatccag atctttgtga     2400

tgagggtgtt gctcgttgcc ctcgctctcc tggctctcgc tgcgagcgcc acctccgctc     2460

agccagctaa gaacgtggag aaggattaca tcgtcggctt caagagcggc gtcaagacag     2520

cttctgttaa gaaggacatc attaaggaga gcggcggcaa ggttgataag caattcagaa     2580

tcattaacgc ggccaaggct aagctcgaca aggaggcgct taaggaggtg aagaatgacc     2640

cggatgttgc ctacgtggag gaggatcacg tcgcccatgc tctggcgcag actgttccgt     2700

acggcatccc actcattaag gccgacaagg tgcaggctca aggcttcaag ggcgcgaacg     2760

tgaaggtcgc cgttcttgac accggcatcc aagcttcaca ccctgatctg aatgtggtcg     2820

gaggagcttc gttcgtcgct ggagaggcct acaacactga cggaaatggc cacggcaccc     2880

atgtggctgg cactgtcgct gcgcttgata acaccactgg agtcctgggc gttgctccat     2940

cagtgtcgct gtacgctgtg aaggtcctca actccagcgg ctccggcagc tactctggca     3000

tcgtgtctgg cattgagtgg gctacaacga acggcatgga cgtcattaat atgagcctcg     3060

gcggagcttc aggatcgacc gcgatgaagc aggccgtcga taacgcctac gctagaggcg     3120

ttgtggtcgt tgccgctgcg ggcaattccg gctcttcagg caacaccaat actatcggct     3180

acccggccaa gtacgactct gtgattgctg tcggcgcggt tgattccaac agcaatcggg     3240

cgtcattctc gtccgttgga gctgagctcg aggtcatggc tcctggagct ggcgtgtact     3300

ccacctaccc cacaaacacg tacgcgacac ttaatggcac gtcgatggtt tccccacacg     3360

tggctggagc tgctgctctg atcctcagca agcatccaaa cctgtctgcc tcacaggtca     3420

ggaatcgcct cagctctacc gctacttacc ttggctcatc gttctactac ggcaagggcc     3480

tcattaacgt tgaggccgct gcgcaaagcg agaaggacga gctgtgacct aggtccccga     3540

atttccccga tcgttcaaac atttggcaat aaagtttctt aagattgaat cctgttgccg     3600

gtcttgcgat gattatcata taatttctgt tgaattacgt taagcatgta ataattaaca     3660

tgtaatgcat gacgttattt atgagatggg tttttatgat tagagtcccg caattataca     3720

tttaatacgc gatagaaaac aaaatatagc gcgcaaacta ggataaatta tcgcgcgcgg     3780

tgtcatctat gttactagat cgggaattg                                       3809


<210>  54
<211>  2755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2222

<400>  54
aaagtaatca tattatttta tgtgtgaatc ttctttactt tttcatttga ttatgattat       60

gaaggtatga ccttcataac cttcgtccga aatccattat atccaaagga aaataatgct      120

tcgaaggacg aaggattttg atatttaaca ttttatgttg ccttgttctt aattcatagc      180

atttgagaac aagtccccaa caccaatctt tatctttact atattaaagc accagttcaa      240

cgatcgtctc gtgtcaatat tattaaaaaa ctcctacatt tctttataat caacccgcac      300

tcttataatc tcttctctta ctactataat aagagagttt atgtacaaaa taaggtgaaa      360

ttatgtataa gtgttctgga ccttggttgt tggctcatat tcacacaacc taatcaatag      420

aaaacatatg ttttattaaa acaaaattta tcatatatat atatatatat atatatatat      480

atatatatat atataatata aaccgtagca atgcacaggc atatgactag tggcaactta      540

ataccatgtg tgtattaaga tgaataagag gtatccaaat aaataacttg ttcgcttacg      600

tctggatcga aaggggttgg aaacgattaa atctcttcct agtcaaaatt aaatagaagg      660

agatttaatc gatttctccc aatccccttc gatccaggtg caaccgaata agtccttaaa      720

tgttgaggaa cacgaaacaa ccatgcattg gcatgtaaag ctccaagaat tcgttgtatc      780

cttaacaact cacagaacat caaccaaaat tgcacgtcaa gggtattggg taagaaacaa      840

tcaaacaaat cctctctgtg tgcaaagaaa cacggtgagt catgccgaga tcatactcat      900

ctgatataca tgcttacagc tcacaagaca ttacaaacaa ctcatattgc attacaaaga      960

tcgtttcatg aaaaataaaa taggccggaa caggacaaaa atccttgacg tgtaaagtaa     1020

atttacaaca aaaaaaaagc catatgtcaa gctaaatcta attcgtttta cgtagatcaa     1080

caacctgtag aaggcaacaa aactgagcca cgcagaagta cagaatgatt ccagatgaac     1140

catcgacgtg ctacgtaaag agagtgacga gtcatataca tttggcaaga aaccatgaag     1200

ctgcctacag ccgtctcggt ggcataagaa cacaagaaat tgtgttaatt aatcaaagct     1260

ataaataacg ctcgcatgcc tgtgcacttc tccatcacca ccactgggtc ttcagaccat     1320

tagctttatc tactccagag cgcagaagaa cccgatcgac accatgaggg tgttgctcgt     1380

tgccctcgct ctcctggctc tcgctgcgag cgccacctcc gctcagccag ctaagaacgt     1440

ggagaaggat tacatcgtcg gcttcaagag cggcgtcaag acagcttctg ttaagaagga     1500

catcattaag gagagcggcg gcaaggttga taagcaattc agaatcatta acgcggccaa     1560

ggctaagctc gacaaggagg cgcttaagga ggtgaagaat gacccggatg ttgcctacgt     1620

ggaggaggat cacgtcgccc atgctctggc gcagactgtt ccgtacggca tcccactcat     1680

taaggccgac aaggtgcagg ctcaaggctt caagggcgcg aacgtgaagg tcgccgttct     1740

tgacaccggc atccaagctt cacaccctga tctgaatgtg gtcggaggag cttcgttcgt     1800

cgctggagag gcctacaaca ctgacggaaa tggccacggc acccatgtgg ctggcactgt     1860

cgctgcgctt gataacacca ctggagtcct gggcgttgct ccatcagtgt cgctgtacgc     1920

tgtgaaggtc ctcaactcca gcggctccgg cagctactct ggcatcgtgt ctggcattga     1980

gtgggctaca acgaacggca tggacgtcat taatatgagc ctcggcggag cttcaggatc     2040

gaccgcgatg aagcaggccg tcgataacgc ctacgctaga ggcgttgtgg tcgttgccgc     2100

tgcgggcaat tccggctctt caggcaacac caatactatc ggctacccgg ccaagtacga     2160

ctctgtgatt gctgtcggcg cggttgattc caacagcaat cgggcgtcat tctcgtccgt     2220

tggagctgag ctcgaggtca tggctcctgg agctggcgtg tactccacct accccacaaa     2280

cacgtacgcg acacttaatg gcacgtcgat ggtttcccca cacgtggctg gagctgctgc     2340

tctgatcctc agcaagcatc caaacctgtc tgcctcacag gtcaggaatc gcctcagctc     2400

taccgctact taccttggct catcgttcta ctacggcaag ggcctcatta acgttgaggc     2460

cgctgcgcaa tgacctaggt ccccgaattt ccccgatcgt tcaaacattt ggcaataaag     2520

tttcttaaga ttgaatcctg ttgccggtct tgcgatgatt atcatataat ttctgttgaa     2580

ttacgttaag catgtaataa ttaacatgta atgcatgacg ttatttatga gatgggtttt     2640

tatgattaga gtcccgcaat tatacattta atacgcgata gaaaacaaaa tatagcgcgc     2700

aaactaggat aaattatcgc gcgcggtgtc atctatgtta ctagatcggg aattg          2755


<210>  55
<211>  2773
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2223

<400>  55
aaagtaatca tattatttta tgtgtgaatc ttctttactt tttcatttga ttatgattat       60

gaaggtatga ccttcataac cttcgtccga aatccattat atccaaagga aaataatgct      120

tcgaaggacg aaggattttg atatttaaca ttttatgttg ccttgttctt aattcatagc      180

atttgagaac aagtccccaa caccaatctt tatctttact atattaaagc accagttcaa      240

cgatcgtctc gtgtcaatat tattaaaaaa ctcctacatt tctttataat caacccgcac      300

tcttataatc tcttctctta ctactataat aagagagttt atgtacaaaa taaggtgaaa      360

ttatgtataa gtgttctgga ccttggttgt tggctcatat tcacacaacc taatcaatag      420

aaaacatatg ttttattaaa acaaaattta tcatatatat atatatatat atatatatat      480

atatatatat atataatata aaccgtagca atgcacaggc atatgactag tggcaactta      540

ataccatgtg tgtattaaga tgaataagag gtatccaaat aaataacttg ttcgcttacg      600

tctggatcga aaggggttgg aaacgattaa atctcttcct agtcaaaatt aaatagaagg      660

agatttaatc gatttctccc aatccccttc gatccaggtg caaccgaata agtccttaaa      720

tgttgaggaa cacgaaacaa ccatgcattg gcatgtaaag ctccaagaat tcgttgtatc      780

cttaacaact cacagaacat caaccaaaat tgcacgtcaa gggtattggg taagaaacaa      840

tcaaacaaat cctctctgtg tgcaaagaaa cacggtgagt catgccgaga tcatactcat      900

ctgatataca tgcttacagc tcacaagaca ttacaaacaa ctcatattgc attacaaaga      960

tcgtttcatg aaaaataaaa taggccggaa caggacaaaa atccttgacg tgtaaagtaa     1020

atttacaaca aaaaaaaagc catatgtcaa gctaaatcta attcgtttta cgtagatcaa     1080

caacctgtag aaggcaacaa aactgagcca cgcagaagta cagaatgatt ccagatgaac     1140

catcgacgtg ctacgtaaag agagtgacga gtcatataca tttggcaaga aaccatgaag     1200

ctgcctacag ccgtctcggt ggcataagaa cacaagaaat tgtgttaatt aatcaaagct     1260

ataaataacg ctcgcatgcc tgtgcacttc tccatcacca ccactgggtc ttcagaccat     1320

tagctttatc tactccagag cgcagaagaa cccgatcgac accatgaggg tgttgctcgt     1380

tgccctcgct ctcctggctc tcgctgcgag cgccacctcc gctcagccag ctaagaacgt     1440

ggagaaggat tacatcgtcg gcttcaagag cggcgtcaag acagcttctg ttaagaagga     1500

catcattaag gagagcggcg gcaaggttga taagcaattc agaatcatta acgcggccaa     1560

ggctaagctc gacaaggagg cgcttaagga ggtgaagaat gacccggatg ttgcctacgt     1620

ggaggaggat cacgtcgccc atgctctggc gcagactgtt ccgtacggca tcccactcat     1680

taaggccgac aaggtgcagg ctcaaggctt caagggcgcg aacgtgaagg tcgccgttct     1740

tgacaccggc atccaagctt cacaccctga tctgaatgtg gtcggaggag cttcgttcgt     1800

cgctggagag gcctacaaca ctgacggaaa tggccacggc acccatgtgg ctggcactgt     1860

cgctgcgctt gataacacca ctggagtcct gggcgttgct ccatcagtgt cgctgtacgc     1920

tgtgaaggtc ctcaactcca gcggctccgg cagctactct ggcatcgtgt ctggcattga     1980

gtgggctaca acgaacggca tggacgtcat taatatgagc ctcggcggag cttcaggatc     2040

gaccgcgatg aagcaggccg tcgataacgc ctacgctaga ggcgttgtgg tcgttgccgc     2100

tgcgggcaat tccggctctt caggcaacac caatactatc ggctacccgg ccaagtacga     2160

ctctgtgatt gctgtcggcg cggttgattc caacagcaat cgggcgtcat tctcgtccgt     2220

tggagctgag ctcgaggtca tggctcctgg agctggcgtg tactccacct accccacaaa     2280

cacgtacgcg acacttaatg gcacgtcgat ggtttcccca cacgtggctg gagctgctgc     2340

tctgatcctc agcaagcatc caaacctgtc tgcctcacag gtcaggaatc gcctcagctc     2400

taccgctact taccttggct catcgttcta ctacggcaag ggcctcatta acgttgaggc     2460

cgctgcgcaa agcgagaagg acgagctgtg acctaggtcc ccgaatttcc ccgatcgttc     2520

aaacatttgg caataaagtt tcttaagatt gaatcctgtt gccggtcttg cgatgattat     2580

catataattt ctgttgaatt acgttaagca tgtaataatt aacatgtaat gcatgacgtt     2640

atttatgaga tgggttttta tgattagagt cccgcaatta tacatttaat acgcgataga     2700

aaacaaaata tagcgcgcaa actaggataa attatcgcgc gcggtgtcat ctatgttact     2760

agatcgggaa ttg                                                        2773


<210>  56
<211>  12310
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pAG2005

<400>  56
aattcatact aaagcttgca tgcctgcagg tcgactctag taacggccgc cagtgtgctg       60

gaattaattc ggcttgtcga ccacccaacc ccatatcgac agaggatgtg aagaacaggt      120

aaatcacgca gaagaaccca tctctgatag cagctatcga ttagaacaac gaatccatat      180

tgggtccgtg ggaaatactt actgcacagg aagggggcga tctgacgagg ccccgccacc      240

ggcctcgacc cgaggccgag gccgacgaag cgccggcgag tacggcgccg cggcggcctc      300

tgcccgtgcc ctctgcgcgt gggagggaga ggccgcggtg gtgggggcgc gcgcgcgcgc      360

gcgcgcagct ggtgcggcgg cgcgggggtc agccgccgag ccggcggcga cggaggagca      420

gggcggcgtg gacgcgaact tccgatcggt tggtcagagt gcgcgagttg ggcttagcca      480

attaggtctc aacaatctat tgggccgtaa aattcatggg ccctggtttg tctaggccca      540

atatcccgtt catttcagcc cacaaatatt tccccagagg attattaagg cccacacgca      600

gcttatagca gatcaagtac gatgtttcct gatcgttgga tcggaaacgt acggtcttga      660

tcaggcatgc cgacttcgtc aaagagaggc ggcatgacct gacgcggagt tggttccggg      720

caccgtctgg atggtcgtac cgggaccgga cacgtgtcgc gcctccaact acatggacac      780

gtgtggtgct gccattgggc cgtacgcgtg gcggtgaccg caccggatgc tgcctcgcac      840

cgccttgccc acgctttata tagagaggtt ttctctccat taatcgcata gcgagtcgaa      900

tcgaccgaag gggaggggga gcgaagcttt gcgttctcta atcgcctcgt caaggtaact      960

aatcaatcac ctcgtcctaa tcctcgaatc tctcgtggtg cccgtctaat ctcgcgattt     1020

tgatgctcgt ggtggaaagc gtaggaggat cccgtgcgag ttagtctcaa tctctcaggg     1080

tttcgtgcga ttttagggtg atccacctct taatcgagtt acggtttcgt gcgattttag     1140

ggtaatcctc ttaatctctc attgatttag ggtttcgtga gaatcgaggt agggatctgt     1200

gttatttata tcgatctaat agatggattg gttttgagat tgttctgtca gatggggatt     1260

gtttcgatat attaccctaa tgatgtgtca gatggggatt gtttcgatat attaccctaa     1320

tgatgtgtca gatggggatt gtttcgatat attaccctaa tgatggataa taagagtagt     1380

tcacagttat gttttgatcc tgccacatag tttgagtttt gtgatcagat ttagttttac     1440

ttatttgtgc ttagttcgga tgggattgtt ctgatattgt tccaatagat gaatagctcg     1500

ttaggttaaa atctttaggt tgagttaggc gacacatagt ttatttcctc tggatttgga     1560

ttggaattgt gttcttagtt tttttcccct ggatttggat tggaattgtg tggagctggg     1620

ttagagaatt acatctgtat cgtgtacacc tacttgaact gtagagcttg ggttctaagg     1680

tcaatttaat ctgtattgta tctggctctt tgcctagttg aactgtagtg ctgatgttgt     1740

actgtgtttt tttacccgtt ttatttgctt tactcgtgca aatcaaatct gtcagatgct     1800

agaactaggt ggctttattc tgtgttctta catagatctg ttgtcctgta gttacttatg     1860

tcagttttgt tattatctga agatattttt ggttgttgct tgttgatgtg gtgtgagctg     1920

tgagcagcgc tcttatgatt aatgatgctg tccaattgta gtgtagtatg atgtgattga     1980

tatgttcatc tattttgagc tgacagtacc gatatcgtag gatctggtgc caacttattc     2040

tccagctgct tttttttacc tatgttaatt ccaatccttt cttgcctctc cagatccaga     2100

taatgcagaa actcattaac tcagtgcaaa actatgcctg gggcagcaaa acggcgttga     2160

ctgaacttta tggtatggaa aatccgtcca gccagccgat ggccgagctg tggatgggcg     2220

cacatccgaa aagcagttca cgagtgcaga atgccgccgg agatatcgtt tcactgcgtg     2280

atgtgattga gagtgataaa tcgactctgc tcggagaggc cgttgccaaa cgctttggcg     2340

aactgccttt cctgttcaaa gtattatgcg cagcacagcc actctccatt caggttcatc     2400

caaacaaaca caattctgaa atcggttttg ccaaagaaaa tgccgcaggt atcccgatgg     2460

atgccgccga gcgtaactat aaagatccta accacaagcc ggagctggtt tttgcgctga     2520

cgcctttcct tgcgatgaac gcgtttcgtg aattttccga gattgtctcc ctactccagc     2580

cggtcgcagg tgcacatccg gcgattgctc actttttaca acagcctgat gccgaacgtt     2640

taagcgaact gttcgccagc ctgttgaata tgcagggtga agaaaaatcc cgcgcgctgg     2700

cgattttaaa atcggccctc gatagccagc agggtgaacc gtggcaaacg attcgtttaa     2760

tttctgaatt ttacccggaa gacagcggtc tgttctcccc gctattgctg aatgtggtga     2820

aattgaaccc tggcgaagcg atgttcctgt tcgctgaaac accgcacgct tacctgcaag     2880

gcgtggcgct ggaagtgatg gcaaactccg ataacgtgct gcgtgcgggt ctgacgccta     2940

aatacattga tattccggaa ctggttgcca atgtgaaatt cgaagccaaa ccggctaacc     3000

agttgttgac ccagccggtg aaacaaggtg cagaactgga cttcccgatt ccagtggatg     3060

attttgcctt ctcgctgcat gaccttagtg ataaagaaac caccattagc cagcagagtg     3120

ccgccatttt gttctgcgtc gaaggcgatg caacgttgtg gaaaggttct cagcagttac     3180

agcttaaacc gggtgaatca gcgtttattg ccgccaacga atcaccggtg actgtcaaag     3240

gccacggccg tttagcgcgt gtttacaaca agctgtaaga gcttactgaa aaaattaaca     3300

tctcttgcta agctgggagc tctagatccc cgaatttccc cgatcgttca aacatttggc     3360

aataaagttt cttaagattg aatcctgttg ccggtcttgc gatgattatc atataatttc     3420

tgttgaatta cgttaagcat gtaataatta acatgtaatg catgacgtta tttatgagat     3480

gggtttttat gattagagtc ccgcaattat acatttaata cgcgatagaa aacaaaatat     3540

agcgcgcaaa ctaggataaa ttatcgcgcg cggtgtcatc tatgttacta gatcgggaat     3600

tggcgagctc gaattaattc agtacattaa aaacgtccgc aatgtgttat taagttgtct     3660

aagcgtcaat ttgtttacac cacaatatat cctgccacca gccagccaac agctccccga     3720

ccggcagctc ggcacaaaat caccactcga tacaggcagc ccatcagtcc gggacggcgt     3780

cagcgggaga gccgttgtaa ggcggcagac tttgctcatg ttaccgatgc tattcggaag     3840

aacggcaact aagctgccgg gtttgaaaca cggatgatct cgcggagggt agcatgttga     3900

ttgtaacgat gacagagcgt tgctgcctgt gatcaaatat catctccctc gcagagatcc     3960

gaattatcag ccttcttatt catttctcgc ttaaccgtga caggctgtcg atcttgagaa     4020

ctatgccgac ataataggaa atcgctggat aaagccgctg aggaagctga gtggcgctat     4080

ttctttagaa gtgaacgttg acgatcgtcg accgtacccc gatgaattaa ttcggacgta     4140

cgttctgaac acagctggat acttacttgg gcgattgtca tacatgacat caacaatgta     4200

cccgtttgtg taaccgtctc ttggaggttc gtatgacact agtggttccc ctcagcttgc     4260

gactagatgt tgaggcctaa cattttatta gagagcaggc tagttgctta gatacatgat     4320

cttcaggccg ttatctgtca gggcaagcga aaattggcca tttatgacga ccaatgcccc     4380

gcagaagctc ccatctttgc cgccatagac gccgcgcccc ccttttgggg tgtagaacat     4440

ccttttgcca gatgtggaaa agaagttcgt tgtcccattg ttggcaatga cgtagtagcc     4500

ggcgaaagtg cgagacccat ttgcgctata tataagccta cgatttccgt tgcgactatt     4560

gtcgtaattg gatgaactat tatcgtagtt gctctcagag ttgtcgtaat ttgatggact     4620

attgtcgtaa ttgcttatgg agttgtcgta gttgcttgga gaaatgtcgt agttggatgg     4680

ggagtagtca tagggaagac gagcttcatc cactaaaaca attggcaggt cagcaagtgc     4740

ctgccccgat gccatcgcaa gtacgaggct tagaaccacc ttcaacagat cgcgcatagt     4800

cttccccagc tctctaacgc ttgagttaag ccgcgccgcg aagcggcgtc ggcttgaacg     4860

aattgttaga cattatttgc cgactacctt ggtgatctcg cctttcacgt agtgaacaaa     4920

ttcttccaac tgatctgcgc gcgaggccaa gcgatcttct tgtccaagat aagcctgcct     4980

agcttcaagt atgacgggct gatactgggc cggcaggcgc tccattgccc agtcggcagc     5040

gacatccttc ggcgcgattt tgccggttac tgcgctgtac caaatgcggg acaacgtaag     5100

cactacattt cgctcatcgc cagcccagtc gggcggcgag ttccatagcg ttaaggtttc     5160

atttagcgcc tcaaatagat cctgttcagg aaccggatca aagagttcct ccgccgctgg     5220

acctaccaag gcaacgctat gttctcttgc ttttgtcagc aagatagcca gatcaatgtc     5280

gatcgtggct ggctcgaaga tacctgcaag aatgtcattg cgctgccatt ctccaaattg     5340

cagttcgcgc ttagctggat aacgccacgg aatgatgtcg tcgtgcacaa caatggtgac     5400

ttctacagcg cggagaatct cgctctctcc aggggaagcc gaagtttcca aaaggtcgtt     5460

gatcaaagct cgccgcgttg tttcatcaag ccttacggtc accgtaacca gcaaatcaat     5520

atcactgtgt ggcttcaggc cgccatccac tgcggagccg tacaaatgta cggccagcaa     5580

cgtcggttcg agatggcgct cgatgacgcc aactacctct gatagttgag tcgatacttc     5640

ggcgatcacc gcttccctca tgatgtttaa ctcctgaatt aagccgcgcc gcgaagcggt     5700

gtcggcttga atgaattgtt aggcgtcatc ctgtgctccc gagaaccagt accagtacat     5760

cgctgtttcg ttcgagactt gaggtctagt tttatacgtg aacaggtcaa tgccgccgag     5820

agtaaagcca cattttgcgt acaaattgca ggcaggtaca ttgttcgttt gtgtctctaa     5880

tcgtatgcca aggagctgtc tgcttagtgc ccactttttc gcaaattcga tgagactgtg     5940

cgcgactcct ttgcctcggt gcgtgtgcga cacaacaatg tgttcgatag aggctagatc     6000

gttccatgtt gagttgagtt caatcttccc gacaagctct tggtcgatga atgcgccata     6060

gcaagcagag tcttcatcag agtcatcatc cgagatgtaa tccttccggt aggggctcac     6120

acttctggta gatagttcaa agccttggtc ggataggtgc acatcgaaca cttcacgaac     6180

aatgaaatgg ttctcagcat ccaatgtttc cgccacctgc tcagggatca ccgaaatctt     6240

catatgacgc ctaacgcctg gcacagcgga tcgcaaacct ggcgcggctt ttggcacaaa     6300

aggcgtgaca ggtttgcgaa tccgttgctg ccacttgtta acccttttgc cagatttggt     6360

aactataatt tatgttagag gcgaagtctt gggtaaaaac tggcctaaaa ttgctgggga     6420

tttcaggaaa gtaaacatca ccttccggct cgatgtctat tgtagatata tgtagtgtat     6480

ctacttgatc gggggatctg ctgcctcgcg cgtttcggtg atgacggtga aaacctctga     6540

cacatgcagc tcccggagac ggtcacagct tgtctgtaag cggatgccgg gagcagacaa     6600

gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg gcgcagccat gacccagtca     6660

cgtagcgata gcggagtgta tactggctta actatgcggc atcagagcag attgtactga     6720

gagtgcacca tatgcggtgt gaaataccgc acagatgcgt aaggagaaaa taccgcatca     6780

ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag     6840

cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag     6900

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     6960

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     7020

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     7080

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     7140

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     7200

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     7260

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     7320

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     7380

ggtggcctaa ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc     7440

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     7500

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     7560

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     7620

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     7680

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     7740

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc     7800

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga     7860

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa     7920

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt     7980

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg     8040

ctgcaggggg gggggggggg gggttccatt gttcattcca cggacaaaaa cagagaaagg     8100

aaacgacaga ggccaaaaag ctcgctttca gcacctgtcg tttcctttct tttcagaggg     8160

tattttaaat aaaaacatta agttatgacg aagaagaacg gaaacgcctt aaaccggaaa     8220

attttcataa atagcgaaaa cccgcgaggt cgccgccccg taacctgtcg gatcaccgga     8280

aaggacccgt aaagtgataa tgattatcat ctacatatca caacgtgcgt ggaggccatc     8340

aaaccacgtc aaataatcaa ttatgacgca ggtatcgtat taattgatct gcatcaactt     8400

aacgtaaaaa caacttcaga caatacaaat cagcgacact gaatacgggg caacctcatg     8460

tccccccccc cccccccctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc     8520

attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa     8580

agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc     8640

actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt     8700

ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag     8760

ttgctcttgc ccggcgtcaa cacgggataa taccgcgcca catagcagaa ctttaaaagt     8820

gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag     8880

atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac     8940

cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc     9000

gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca     9060

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg     9120

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat     9180

gacattaacc tataaaaata ggcgtatcac gaggcccttt cgtcttcaag aattggtcga     9240

cgatcttgct gcgttcggat attttcgtgg agttcccgcc acagacccgg attgaaggcg     9300

agatccagca actcgcgcca gatcatcctg tgacggaact ttggcgcgtg atgactggcc     9360

aggacgtcgg ccgaaagagc gacaagcaga tcacgctttt cgacagcgtc ggatttgcga     9420

tcgaggattt ttcggcgctg cgctacgtcc gcgaccgcgt tgagggatca agccacagca     9480

gcccactcga ccttctagcc gacccagacg agccaaggga tctttttgga atgctgctcc     9540

gtcgtcaggc tttccgacgt ttgggtggtt gaacagaagt cattatcgca cggaatgcca     9600

agcactcccg aggggaaccc tgtggttggc atgcacatac aaatggacga acggataaac     9660

cttttcacgc ccttttaaat atccgattat tctaataaac gctcttttct cttaggttta     9720

cccgccaata tatcctgtca aacactgata gtttaaactg aaggcgggaa acgacaacct     9780

gatcatgagc ggagaattaa gggagtcacg ttatgacccc cgccgatgac gcgggacaag     9840

ccgttttacg tttggaactg acagaaccgc aacgttgaag gagccactca gcttaattaa     9900

gtctaactcg agttactggt acgtaccaaa tccatggaat caaggtaccg tcgactctag     9960

taacggccgc cagtgtgctg gaattaattc ggcttgtcga ccacccaacc ccatatcgac    10020

agaggatgtg aagaacaggt aaatcacgca gaagaaccca tctctgatag cagctatcga    10080

ttagaacaac gaatccatat tgggtccgtg ggaaatactt actgcacagg aagggggcga    10140

tctgacgagg ccccgccacc ggcctcgacc cgaggccgag gccgacgaag cgccggcgag    10200

tacggcgccg cggcggcctc tgcccgtgcc ctctgcgcgt gggagggaga ggccgcggtg    10260

gtgggggcgc gcgcgcgcgc gcgcgcagct ggtgcggcgg cgcgggggtc agccgccgag    10320

ccggcggcga cggaggagca gggcggcgtg gacgcgaact tccgatcggt tggtcagagt    10380

gcgcgagttg ggcttagcca attaggtctc aacaatctat tgggccgtaa aattcatggg    10440

ccctggtttg tctaggccca atatcccgtt catttcagcc cacaaatatt tccccagagg    10500

attattaagg cccacacgca gcttatagca gatcaagtac gatgtttcct gatcgttgga    10560

tcggaaacgt acggtcttga tcaggcatgc cgacttcgtc aaagagaggc ggcatgacct    10620

gacgcggagt tggttccggg caccgtctgg atggtcgtac cgggaccgga cacgtgtcgc    10680

gcctccaact acatggacac gtgtggtgct gccattgggc cgtacgcgtg gcggtgaccg    10740

caccggatgc tgcctcgcac cgccttgccc acgctttata tagagaggtt ttctctccat    10800

taatcgcata gcgagtcgaa tcgaccgaag gggaggggga gcgaagcttt gcgttctcta    10860

atcgcctcgt caaggtaact aatcaatcac ctcgtcctaa tcctcgaatc tctcgtggtg    10920

cccgtctaat ctcgcgattt tgatgctcgt ggtggaaagc gtaggaggat cccgtgcgag    10980

ttagtctcaa tctctcaggg tttcgtgcga ttttagggtg atccacctct taatcgagtt    11040

acggtttcgt gcgattttag ggtaatcctc ttaatctctc attgatttag ggtttcgtga    11100

gaatcgaggt agggatctgt gttatttata tcgatctaat agatggattg gttttgagat    11160

tgttctgtca gatggggatt gtttcgatat attaccctaa tgatgtgtca gatggggatt    11220

gtttcgatat attaccctaa tgatgtgtca gatggggatt gtttcgatat attaccctaa    11280

tgatggataa taagagtagt tcacagttat gttttgatcc tgccacatag tttgagtttt    11340

gtgatcagat ttagttttac ttatttgtgc ttagttcgga tgggattgtt ctgatattgt    11400

tccaatagat gaatagctcg ttaggttaaa atctttaggt tgagttaggc gacacatagt    11460

ttatttcctc tggatttgga ttggaattgt gttcttagtt tttttcccct ggatttggat    11520

tggaattgtg tggagctggg ttagagaatt acatctgtat cgtgtacacc tacttgaact    11580

gtagagcttg ggttctaagg tcaatttaat ctgtattgta tctggctctt tgcctagttg    11640

aactgtagtg ctgatgttgt actgtgtttt tttacccgtt ttatttgctt tactcgtgca    11700

aatcaaatct gtcagatgct agaactaggt ggctttattc tgtgttctta catagatctg    11760

ttgtcctgta gttacttatg tcagttttgt tattatctga agatattttt ggttgttgct    11820

tgttgatgtg gtgtgagctg tgagcagcgc tcttatgatt aatgatgctg tccaattgta    11880

gtgtagtatg atgtgattga tatgttcatc tattttgagc tgacagtacc gatatcgtag    11940

gatctggtgc caacttattc tccagctgct tttttttacc tatgttaatt ccaatccttt    12000

cttgcctctt ccagcccggg tattcatcct aggtccccga atttccccga tcgttcaaac    12060

atttggcaat aaagtttctt aagattgaat cctgttgccg gtcttgcgat gattatcata    12120

taatttctgt tgaattacgt taagcatgta ataattaaca tgtaatgcat gacgttattt    12180

atgagatggg tttttatgat tagagtcccg caattataca tttaatacgc gatagaaaac    12240

aaaatatagc gcgcaaacta ggataaatta tcgcgcgcgg tgtcatctat gttactagat    12300

cgggaattgg                                                           12310


<210>  57
<211>  354
<212>  PRT
<213>  Bacillus lentus


<220>
<221>  MISC_FEATURE
<222>  (1)..(354)
<223>  Pro-savinase

<400>  57

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
    290                 295                 300                 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
305                 310                 315                 320 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                325                 330                 335     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            340                 345                 350         


Thr Arg 
        


<210>  58
<211>  270
<212>  PRT
<213>  Bacillus lentus


<220>
<221>  MISC_FEATURE
<222>  (1)..(270)
<223>  Savinase catalytic domain

<400>  58

Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala 
1               5                   10                  15      


Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu 
            20                  25                  30          


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
    50                  55                  60                  


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
65                  70                  75                  80  


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
                85                  90                  95      


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
            100                 105                 110         


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
        115                 120                 125             


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
    130                 135                 140                 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
145                 150                 155                 160 


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
                165                 170                 175     


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
            180                 185                 190         


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
        195                 200                 205             


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
    210                 215                 220                 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
225                 230                 235                 240 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
                245                 250                 255     


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            260                 265                 270 


<210>  59
<211>  1143
<212>  DNA
<213>  Bacillus lentus


<220>
<221>  misc_feature
<222>  (1)..(1143)
<223>  P29600

<400>  59
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggttc aacatatgcc      960

agcttaaacg gtacatcgat ggctactcct catgttgcag gtgcggccgc ccttgttaaa     1020

caaaagaacc catcttggtc taatgtacaa attcgaaatc atctaaagaa tacggcaact     1080

agtttaggaa gcacgaactt gtatggaagc ggacttgtta acgcagaagc ggcaacgcgt     1140

taa                                                                   1143


<210>  60
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT01-preprosavinase-8His

<400>  60
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggttc aacatatgcc      960

agcttaaacg gtacatcgat ggctactcct catgttgcag gtgcggccgc ccttgttaaa     1020

caaaagaacc catcttggtc taatgtacaa attcgaaatc atctaaagaa tacggcaact     1080

agtttaggaa gcacgaactt gtatggaagc ggacttgtta acgcagaagc ggcaacgcgt     1140

caccatcacc atcatcacca ccattaa                                         1167


<210>  61
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT01-pre-prosavinase-8His

<400>  61

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            260                 265                 270         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        275                 280                 285             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    290                 295                 300                 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
305                 310                 315                 320 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
                325                 330                 335     


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
            340                 345                 350         


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
        355                 360                 365             


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg His His His His 
    370                 375                 380                 


His His His His 
385             


<210>  62
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT01-prosavinase-8His

<400>  62
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tcaacatatg ccagcttaaa cggtacatcg      900

atggctactc ctcatgttgc aggtgcggcc gcccttgtta aacaaaagaa cccatcttgg      960

tctaatgtac aaattcgaaa tcatctaaag aatacggcaa ctagtttagg aagcacgaac     1020

ttgtatggaa gcggacttgt taacgcagaa gcggcaacgc gtcaccatca ccatcatcac     1080

caccattaa                                                             1089


<210>  63
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT01-prosavinase-8His

<400>  63

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
    290                 295                 300                 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
305                 310                 315                 320 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                325                 330                 335     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            340                 345                 350         


Thr Arg His His His His His His His His 
        355                 360         


<210>  64
<211>  837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT01-savinase-8His

<400>  64
atggcgcaat cggtaccatg gggaattagc cgtgtgcaag ccccagctgc ccataaccgt       60

ggattgacag gttctggtgt aaaagttgct gtcctcgata cagggatatc cactcatcca      120

gatctaaata ttcgtggtgg cgcaagcttt gtaccagggg aaccgtcgac tcaagatggg      180

aatgggcatg gcacgcatgt ggccgggacg atcgctgctt taaacaattc gattggcgtt      240

cttggcgtag cgccgagcgc tgagctatac gctgttaaag tcctaggggc gagcggttca      300

ggttcggtca gctcgattgc ccaaggattg gaatgggcag ggaacaatgg catgcacgtt      360

gctaatttga gtttaggaag cccttcgcca agtgccacac ttgagcaagc tgttaatagc      420

gcgacttcta gaggcgttct tgttgtagcg gcatctggga actcaggtgc aggctcaatc      480

agctatccgg cgcgctatgc gaacgcaatg gcagtcggag ctactgatca aaacaacaac      540

cgcgctagct tttcacagta tggcgcaggc cttgacattg tcgcacccgg ggtaaacgtg      600

cagagcacat acccaggttc aacatatgcc agcttaaacg gtacatcgat ggctactcct      660

catgttgcag gtgcggccgc ccttgttaaa caaaagaacc catcttggtc taatgtacaa      720

attcgaaatc atctaaagaa tacggcaact agtttaggaa gcacgaactt gtatggaagc      780

ggacttgtta acgcagaagc ggcaacgcgt caccatcacc atcatcacca ccattaa         837


<210>  65
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT01-savinase-8His

<400>  65

Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala 
1               5                   10                  15      


Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu 
            20                  25                  30          


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
    50                  55                  60                  


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
65                  70                  75                  80  


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
                85                  90                  95      


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
            100                 105                 110         


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
        115                 120                 125             


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
    130                 135                 140                 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
145                 150                 155                 160 


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
                165                 170                 175     


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
            180                 185                 190         


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
        195                 200                 205             


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
    210                 215                 220                 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
225                 230                 235                 240 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
                245                 250                 255     


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg His His 
            260                 265                 270         


His His His His His His 
        275             


<210>  66
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT43-preprosavinase-8His

<400>  66
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggttc aacatatgcc      960

agcttaaacg gtacatcgat ggctactcct catgttgcag gtgcggccgc ccttgttaaa     1020

caaaagaacc catcttggtc taatgtacaa attcgaaatc atctaaagaa tacggcaact     1080

agtttaggaa gcacgaactt gtatggaagc ggacttgtta acgcagaagc ggcaacgcgt     1140

caccatcacc atcatcacca ccattaa                                         1167


<210>  67
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT43-preprosavinase-8His

<400>  67

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            260                 265                 270         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        275                 280                 285             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    290                 295                 300                 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
305                 310                 315                 320 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
                325                 330                 335     


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
            340                 345                 350         


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
        355                 360                 365             


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg His His His His 
    370                 375                 380                 


His His His His 
385             


<210>  68
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT43-prosavinase-8His

<400>  68
atgattcaaa aacgaaagcg gacagtttcg ttcagacttg tgcttatgtg cacgctgtta       60

tttgtcagtt tgccgattac aaaaacatca gccgtaggat ccgctgaaga agcaaaagaa      120

aaatatttaa ttggctttaa tgagcaggaa gctgtcagtg agtttgtaga acaagtagag      180

gcaaatgacg aggtcgccat tctctctgag gaagaggaag tcgaaattga attgcttcat      240

gaatttgaaa cgattcctgt tttatccgtt gagttaagcc cagaagatgt ggacgcgctt      300

gaactcgatc cagcgatttc ttatattgaa gaggatgcag aagtaacgac aatggcgcaa      360

tcggtaccat ggggaattag ccgtgtgcaa gccccagctg cccataaccg tggattgaca      420

ggttctggtg taaaagttgc tgtcctcgat acagggatat ccactcatcc agatctaaat      480

attcgtggtg gcgcaagctt tgtaccaggg gaaccgtcga ctcaagatgg gaatgggcat      540

ggcacgcatg tggccgggac gatcgctgct ttaaacaatt cgattggcgt tcttggcgta      600

gcgccgagcg ctgagctata cgctgttaaa gtcctagggg cgagcggttc aggttcggtc      660

agctcgattg cccaaggatt ggaatgggca gggaacaatg gcatgcacgt tgctaatttg      720

agtttaggaa gcccttcgcc aagtgccaca cttgagcaag ctgttaatag cgcgacttct      780

agaggcgttc ttgttgtagc ggcatctggg aactcaggtg caggctcaat cagctatccg      840

gcgcgctatg cgaacgcaat ggcagtcgga gctactgatc aaaacaacaa ccgcgctagc      900

ttttcacagt atggcgcagg ccttgacatt gtcgcacccg gggtaaacgt gcagagcaca      960

tacccaggtt caacatatgc cagcttaaac ggtacatcga tggctactcc tcatgttgca     1020

ggtgcggccg cccttgttaa acaaaagaac ccatcttggt ctaatgtaca aattcgaaat     1080

catctaaaga atacggcaac tagtttagga agcacgaact tgtatggaag cggacttgtt     1140

aacgcagaag cggcaacgcg tcaccatcac catcatcacc accattaa                  1188


<210>  69
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT43-prosavinase-8His

<400>  69

Met Ile Gln Lys Arg Lys Arg Thr Val Ser Phe Arg Leu Val Leu Met 
1               5                   10                  15      


Cys Thr Leu Leu Phe Val Ser Leu Pro Ile Thr Lys Thr Ser Ala Val 
            20                  25                  30          


Gly Ser Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu 
        35                  40                  45              


Gln Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu 
    50                  55                  60                  


Val Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His 
65                  70                  75                  80  


Glu Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp 
                85                  90                  95      


Val Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp 
            100                 105                 110         


Ala Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg 
        115                 120                 125             


Val Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val 
    130                 135                 140                 


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
145                 150                 155                 160 


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
                165                 170                 175     


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
            180                 185                 190         


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
        195                 200                 205             


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
    210                 215                 220                 


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
225                 230                 235                 240 


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
                245                 250                 255     


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
            260                 265                 270         


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
        275                 280                 285             


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
    290                 295                 300                 


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
305                 310                 315                 320 


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
                325                 330                 335     


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
            340                 345                 350         


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
        355                 360                 365             


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
    370                 375                 380                 


Ala Thr Arg His His His His His His His His 
385                 390                 395 


<210>  70
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT43-savinase-8His

<400>  70
atgattcaaa aacgaaagcg gacagtttcg ttcagacttg tgcttatgtg cacgctgtta       60

tttgtcagtt tgccgattac aaaaacatca gccgtaggat ccgcgcaatc ggtaccatgg      120

ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg gattgacagg ttctggtgta      180

aaagttgctg tcctcgatac agggatatcc actcatccag atctaaatat tcgtggtggc      240

gcaagctttg taccagggga accgtcgact caagatggga atgggcatgg cacgcatgtg      300

gccgggacga tcgctgcttt aaacaattcg attggcgttc ttggcgtagc gccgagcgct      360

gagctatacg ctgttaaagt cctaggggcg agcggttcag gttcggtcag ctcgattgcc      420

caaggattgg aatgggcagg gaacaatggc atgcacgttg ctaatttgag tttaggaagc      480

ccttcgccaa gtgccacact tgagcaagct gttaatagcg cgacttctag aggcgttctt      540

gttgtagcgg catctgggaa ctcaggtgca ggctcaatca gctatccggc gcgctatgcg      600

aacgcaatgg cagtcggagc tactgatcaa aacaacaacc gcgctagctt ttcacagtat      660

ggcgcaggcc ttgacattgt cgcacccggg gtaaacgtgc agagcacata cccaggttca      720

acatatgcca gcttaaacgg tacatcgatg gctactcctc atgttgcagg tgcggccgcc      780

cttgttaaac aaaagaaccc atcttggtct aatgtacaaa ttcgaaatca tctaaagaat      840

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg      900

gcaacgcgtc accatcacca tcatcaccac cattaa                                936


<210>  71
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pHT43-savinase-8His

<400>  71

Met Ile Gln Lys Arg Lys Arg Thr Val Ser Phe Arg Leu Val Leu Met 
1               5                   10                  15      


Cys Thr Leu Leu Phe Val Ser Leu Pro Ile Thr Lys Thr Ser Ala Val 
            20                  25                  30          


Gly Ser Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro 
        35                  40                  45              


Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val 
    50                  55                  60                  


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
65                  70                  75                  80  


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
                85                  90                  95      


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
            100                 105                 110         


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
        115                 120                 125             


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
    130                 135                 140                 


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
145                 150                 155                 160 


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
                165                 170                 175     


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
            180                 185                 190         


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
        195                 200                 205             


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
    210                 215                 220                 


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
225                 230                 235                 240 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
                245                 250                 255     


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
            260                 265                 270         


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
        275                 280                 285             


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg His 
    290                 295                 300                 


His His His His His His His 
305                 310     


<210>  72
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct mTth:EU59 intein

<400>  72
tgcctggccg agggctcgct cgtcttggac gcggctaccg ggcagagggt ccctatcgaa       60

aaggtgcgtc cggggatgga agttttctcc ttgggacctg attacagact gtatcgggtg      120

cccgttttgg aggtccttga gagcggggtt agggaagttg tgcgcctcag aactcggtca      180

gggagaacgc tggtgttgac accagatcac ccgcttttga cccccgaagg ttggaaacct      240

ctttgtgacc tcccgcttgg aactccaatt gcagtcgccc aaacatgtct gaccagccca      300

caaacaggat tccacaacgg cttcttttac tcgttttgga aagattctcc tggtactgtt      360

aacttttgcc ttcttgaagg gggaagatat acctccaatt ggtctgggat aaacaattgg      420

gtcggtggca agggctggca gaccggtagt aggcgcaaca tcacgtattc cgggagcttc      480

aatacaccag ggaatggata cctggctctc tacggttgga ccaccaaccc gttggttgag      540

tactatgttg tcgatagctg gggctcctgg cgccctcccg gaagtgatgg gacatttctt      600

ggcacagtga actcagacgg cggcacgtat gacatctaca gggcgcaaag agtcaacgca      660

ccgagcatca ttggcaatgc caccttctac cagtattggt ccgtgcggca gtccaagcgt      720

gtcggtggga caatcacgac tggcaaccac ttcgacgcgt gggccagcgt gggcctcaac      780

ctcgggactc ataactacca gataatggct actgagggtt accagtcgtc aggatcttca      840

gacattacgg tgtcaagaga tgttgagact ggagaggttc tctgggaccc tattgttgct      900

gtcgaaccgg ccggtaaggc gagaacattc gacttgcgcg ttccaccctt tgcaaacttc      960

gtgagcgagg acctggtggt gcataac                                          987


<210>  73
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S46

<400>  73
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtctgcctg gccgagggct       60

cgctcgtctt ggacgcggct accgggcaga gggtccctat cgaaaaggtg cgtccgggga      120

tggaagtttt ctccttggga cctgattaca gactgtatcg ggtgcccgtt ttggaggtcc      180

ttgagagcgg ggttagggaa gttgtgcgcc tcagaactcg gtcagggaga acgctggtgt      240

tgacaccaga tcacccgctt ttgacccccg aaggttggaa acctctttgt gacctcccgc      300

ttggaactcc aattgcagtc gcccaaacat gtctgaccag cccacaaaca ggattccaca      360

acggcttctt ttactcgttt tggaaagatt ctcctggtac tgttaacttt tgccttcttg      420

aagggggaag atatacctcc aattggtctg ggataaacaa ttgggtcggt ggcaagggct      480

ggcagaccgg tagtaggcgc aacatcacgt attccgggag cttcaataca ccagggaatg      540

gatacctggc tctctacggt tggaccacca acccgttggt tgagtactat gttgtcgata      600

gctggggctc ctggcgccct cccggaagtg atgggacatt tcttggcaca gtgaactcag      660

acggcggcac gtatgacatc tacagggcgc aaagagtcaa cgcaccgagc atcattggca      720

atgccacctt ctaccagtat tggtccgtgc ggcagtccaa gcgtgtcggt gggacaatca      780

cgactggcaa ccacttcgac gcgtgggcca gcgtgggcct caacctcggg actcataact      840

accagataat ggctactgag ggttaccagt cgtcaggatc ttcagacatt acggtgtcaa      900

gagatgttga gactggagag gttctctggg accctattgt tgctgtcgaa ccggccggta      960

aggcgagaac attcgacttg cgcgttccac cctttgcaaa cttcgtgagc gaggacctgg     1020

tggtgcataa cagtgagttt gtagaacaag tagaggcaaa tgacgaggtc gccattctct     1080

ctgaggaaga ggaagtcgaa attgaattgc ttcatgaatt tgaaacgatt cctgttttat     1140

ccgttgagtt aagcccagaa gatgtggacg cgcttgaact cgatccagcg atttcttata     1200

ttgaagagga tgcagaagta acgacaatgg cgcaatcggt accatgggga attagccgtg     1260

tgcaagcccc agctgcccat aaccgtggat tgacaggttc tggtgtaaaa gttgctgtcc     1320

tcgatacagg gatatccact catccagatc taaatattcg tggtggcgca agctttgtac     1380

caggggaacc gtcgactcaa gatgggaatg ggcatggcac gcatgtggcc gggacgatcg     1440

ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  74
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S62

<400>  74
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctgcctggc cgagggctcg ctcgtcttgg      120

acgcggctac cgggcagagg gtccctatcg aaaaggtgcg tccggggatg gaagttttct      180

ccttgggacc tgattacaga ctgtatcggg tgcccgtttt ggaggtcctt gagagcgggg      240

ttagggaagt tgtgcgcctc agaactcggt cagggagaac gctggtgttg acaccagatc      300

acccgctttt gacccccgaa ggttggaaac ctctttgtga cctcccgctt ggaactccaa      360

ttgcagtcgc ccaaacatgt ctgaccagcc cacaaacagg attccacaac ggcttctttt      420

actcgttttg gaaagattct cctggtactg ttaacttttg ccttcttgaa gggggaagat      480

atacctccaa ttggtctggg ataaacaatt gggtcggtgg caagggctgg cagaccggta      540

gtaggcgcaa catcacgtat tccgggagct tcaatacacc agggaatgga tacctggctc      600

tctacggttg gaccaccaac ccgttggttg agtactatgt tgtcgatagc tggggctcct      660

ggcgccctcc cggaagtgat gggacatttc ttggcacagt gaactcagac ggcggcacgt      720

atgacatcta cagggcgcaa agagtcaacg caccgagcat cattggcaat gccaccttct      780

accagtattg gtccgtgcgg cagtccaagc gtgtcggtgg gacaatcacg actggcaacc      840

acttcgacgc gtgggccagc gtgggcctca acctcgggac tcataactac cagataatgg      900

ctactgaggg ttaccagtcg tcaggatctt cagacattac ggtgtcaaga gatgttgaga      960

ctggagaggt tctctgggac cctattgttg ctgtcgaacc ggccggtaag gcgagaacat     1020

tcgacttgcg cgttccaccc tttgcaaact tcgtgagcga ggacctggtg gtgcataact     1080

ctgaggaaga ggaagtcgaa attgaattgc ttcatgaatt tgaaacgatt cctgttttat     1140

ccgttgagtt aagcccagaa gatgtggacg cgcttgaact cgatccagcg atttcttata     1200

ttgaagagga tgcagaagta acgacaatgg cgcaatcggt accatgggga attagccgtg     1260

tgcaagcccc agctgcccat aaccgtggat tgacaggttc tggtgtaaaa gttgctgtcc     1320

tcgatacagg gatatccact catccagatc taaatattcg tggtggcgca agctttgtac     1380

caggggaacc gtcgactcaa gatgggaatg ggcatggcac gcatgtggcc gggacgatcg     1440

ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  75
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T77

<400>  75
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaatgc ctggccgagg gctcgctcgt cttggacgcg gctaccgggc      180

agagggtccc tatcgaaaag gtgcgtccgg ggatggaagt tttctccttg ggacctgatt      240

acagactgta tcgggtgccc gttttggagg tccttgagag cggggttagg gaagttgtgc      300

gcctcagaac tcggtcaggg agaacgctgg tgttgacacc agatcacccg cttttgaccc      360

ccgaaggttg gaaacctctt tgtgacctcc cgcttggaac tccaattgca gtcgcccaaa      420

catgtctgac cagcccacaa acaggattcc acaacggctt cttttactcg ttttggaaag      480

attctcctgg tactgttaac ttttgccttc ttgaaggggg aagatatacc tccaattggt      540

ctgggataaa caattgggtc ggtggcaagg gctggcagac cggtagtagg cgcaacatca      600

cgtattccgg gagcttcaat acaccaggga atggatacct ggctctctac ggttggacca      660

ccaacccgtt ggttgagtac tatgttgtcg atagctgggg ctcctggcgc cctcccggaa      720

gtgatgggac atttcttggc acagtgaact cagacggcgg cacgtatgac atctacaggg      780

cgcaaagagt caacgcaccg agcatcattg gcaatgccac cttctaccag tattggtccg      840

tgcggcagtc caagcgtgtc ggtgggacaa tcacgactgg caaccacttc gacgcgtggg      900

ccagcgtggg cctcaacctc gggactcata actaccagat aatggctact gagggttacc      960

agtcgtcagg atcttcagac attacggtgt caagagatgt tgagactgga gaggttctct     1020

gggaccctat tgttgctgtc gaaccggccg gtaaggcgag aacattcgac ttgcgcgttc     1080

caccctttgc aaacttcgtg agcgaggacc tggtggtgca taacacgatt cctgttttat     1140

ccgttgagtt aagcccagaa gatgtggacg cgcttgaact cgatccagcg atttcttata     1200

ttgaagagga tgcagaagta acgacaatgg cgcaatcggt accatgggga attagccgtg     1260

tgcaagcccc agctgcccat aaccgtggat tgacaggttc tggtgtaaaa gttgctgtcc     1320

tcgatacagg gatatccact catccagatc taaatattcg tggtggcgca agctttgtac     1380

caggggaacc gtcgactcaa gatgggaatg ggcatggcac gcatgtggcc gggacgatcg     1440

ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  76
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S86

<400>  76
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttatgcctg gccgagggct      180

cgctcgtctt ggacgcggct accgggcaga gggtccctat cgaaaaggtg cgtccgggga      240

tggaagtttt ctccttggga cctgattaca gactgtatcg ggtgcccgtt ttggaggtcc      300

ttgagagcgg ggttagggaa gttgtgcgcc tcagaactcg gtcagggaga acgctggtgt      360

tgacaccaga tcacccgctt ttgacccccg aaggttggaa acctctttgt gacctcccgc      420

ttggaactcc aattgcagtc gcccaaacat gtctgaccag cccacaaaca ggattccaca      480

acggcttctt ttactcgttt tggaaagatt ctcctggtac tgttaacttt tgccttcttg      540

aagggggaag atatacctcc aattggtctg ggataaacaa ttgggtcggt ggcaagggct      600

ggcagaccgg tagtaggcgc aacatcacgt attccgggag cttcaataca ccagggaatg      660

gatacctggc tctctacggt tggaccacca acccgttggt tgagtactat gttgtcgata      720

gctggggctc ctggcgccct cccggaagtg atgggacatt tcttggcaca gtgaactcag      780

acggcggcac gtatgacatc tacagggcgc aaagagtcaa cgcaccgagc atcattggca      840

atgccacctt ctaccagtat tggtccgtgc ggcagtccaa gcgtgtcggt gggacaatca      900

cgactggcaa ccacttcgac gcgtgggcca gcgtgggcct caacctcggg actcataact      960

accagataat ggctactgag ggttaccagt cgtcaggatc ttcagacatt acggtgtcaa     1020

gagatgttga gactggagag gttctctggg accctattgt tgctgtcgaa ccggccggta     1080

aggcgagaac attcgacttg cgcgttccac cctttgcaaa cttcgtgagc gaggacctgg     1140

tggtgcataa cagcccagaa gatgtggacg cgcttgaact cgatccagcg atttcttata     1200

ttgaagagga tgcagaagta acgacaatgg cgcaatcggt accatgggga attagccgtg     1260

tgcaagcccc agctgcccat aaccgtggat tgacaggttc tggtgtaaaa gttgctgtcc     1320

tcgatacagg gatatccact catccagatc taaatattcg tggtggcgca agctttgtac     1380

caggggaacc gtcgactcaa gatgggaatg ggcatggcac gcatgtggcc gggacgatcg     1440

ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  77
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S100

<400>  77
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttgcc tggccgaggg ctcgctcgtc ttggacgcgg      240

ctaccgggca gagggtccct atcgaaaagg tgcgtccggg gatggaagtt ttctccttgg      300

gacctgatta cagactgtat cgggtgcccg ttttggaggt ccttgagagc ggggttaggg      360

aagttgtgcg cctcagaact cggtcaggga gaacgctggt gttgacacca gatcacccgc      420

ttttgacccc cgaaggttgg aaacctcttt gtgacctccc gcttggaact ccaattgcag      480

tcgcccaaac atgtctgacc agcccacaaa caggattcca caacggcttc ttttactcgt      540

tttggaaaga ttctcctggt actgttaact tttgccttct tgaaggggga agatatacct      600

ccaattggtc tgggataaac aattgggtcg gtggcaaggg ctggcagacc ggtagtaggc      660

gcaacatcac gtattccggg agcttcaata caccagggaa tggatacctg gctctctacg      720

gttggaccac caacccgttg gttgagtact atgttgtcga tagctggggc tcctggcgcc      780

ctcccggaag tgatgggaca tttcttggca cagtgaactc agacggcggc acgtatgaca      840

tctacagggc gcaaagagtc aacgcaccga gcatcattgg caatgccacc ttctaccagt      900

attggtccgt gcggcagtcc aagcgtgtcg gtgggacaat cacgactggc aaccacttcg      960

acgcgtgggc cagcgtgggc ctcaacctcg ggactcataa ctaccagata atggctactg     1020

agggttacca gtcgtcagga tcttcagaca ttacggtgtc aagagatgtt gagactggag     1080

aggttctctg ggaccctatt gttgctgtcg aaccggccgg taaggcgaga acattcgact     1140

tgcgcgttcc accctttgca aacttcgtga gcgaggacct ggtggtgcat aactcttata     1200

ttgaagagga tgcagaagta acgacaatgg cgcaatcggt accatgggga attagccgtg     1260

tgcaagcccc agctgcccat aaccgtggat tgacaggttc tggtgtaaaa gttgctgtcc     1320

tcgatacagg gatatccact catccagatc taaatattcg tggtggcgca agctttgtac     1380

caggggaacc gtcgactcaa gatgggaatg ggcatggcac gcatgtggcc gggacgatcg     1440

ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  78
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T109

<400>  78
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtatgcctgg      240

ccgagggctc gctcgtcttg gacgcggcta ccgggcagag ggtccctatc gaaaaggtgc      300

gtccggggat ggaagttttc tccttgggac ctgattacag actgtatcgg gtgcccgttt      360

tggaggtcct tgagagcggg gttagggaag ttgtgcgcct cagaactcgg tcagggagaa      420

cgctggtgtt gacaccagat cacccgcttt tgacccccga aggttggaaa cctctttgtg      480

acctcccgct tggaactcca attgcagtcg cccaaacatg tctgaccagc ccacaaacag      540

gattccacaa cggcttcttt tactcgtttt ggaaagattc tcctggtact gttaactttt      600

gccttcttga agggggaaga tatacctcca attggtctgg gataaacaat tgggtcggtg      660

gcaagggctg gcagaccggt agtaggcgca acatcacgta ttccgggagc ttcaatacac      720

cagggaatgg atacctggct ctctacggtt ggaccaccaa cccgttggtt gagtactatg      780

ttgtcgatag ctggggctcc tggcgccctc ccggaagtga tgggacattt cttggcacag      840

tgaactcaga cggcggcacg tatgacatct acagggcgca aagagtcaac gcaccgagca      900

tcattggcaa tgccaccttc taccagtatt ggtccgtgcg gcagtccaag cgtgtcggtg      960

ggacaatcac gactggcaac cacttcgacg cgtgggccag cgtgggcctc aacctcggga     1020

ctcataacta ccagataatg gctactgagg gttaccagtc gtcaggatct tcagacatta     1080

cggtgtcaag agatgttgag actggagagg ttctctggga ccctattgtt gctgtcgaac     1140

cggccggtaa ggcgagaaca ttcgacttgc gcgttccacc ctttgcaaac ttcgtgagcg     1200

aggacctggt ggtgcataac acgacaatgg cgcaatcggt accatgggga attagccgtg     1260

tgcaagcccc agctgcccat aaccgtggat tgacaggttc tggtgtaaaa gttgctgtcc     1320

tcgatacagg gatatccact catccagatc taaatattcg tggtggcgca agctttgtac     1380

caggggaacc gtcgactcaa gatgggaatg ggcatggcac gcatgtggcc gggacgatcg     1440

ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  79
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S135

<400>  79
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttgcctggcc gagggctcgc tcgtcttgga cgcggctacc gggcagaggg      360

tccctatcga aaaggtgcgt ccggggatgg aagttttctc cttgggacct gattacagac      420

tgtatcgggt gcccgttttg gaggtccttg agagcggggt tagggaagtt gtgcgcctca      480

gaactcggtc agggagaacg ctggtgttga caccagatca cccgcttttg acccccgaag      540

gttggaaacc tctttgtgac ctcccgcttg gaactccaat tgcagtcgcc caaacatgtc      600

tgaccagccc acaaacagga ttccacaacg gcttctttta ctcgttttgg aaagattctc      660

ctggtactgt taacttttgc cttcttgaag ggggaagata tacctccaat tggtctggga      720

taaacaattg ggtcggtggc aagggctggc agaccggtag taggcgcaac atcacgtatt      780

ccgggagctt caatacacca gggaatggat acctggctct ctacggttgg accaccaacc      840

cgttggttga gtactatgtt gtcgatagct ggggctcctg gcgccctccc ggaagtgatg      900

ggacatttct tggcacagtg aactcagacg gcggcacgta tgacatctac agggcgcaaa      960

gagtcaacgc accgagcatc attggcaatg ccaccttcta ccagtattgg tccgtgcggc     1020

agtccaagcg tgtcggtggg acaatcacga ctggcaacca cttcgacgcg tgggccagcg     1080

tgggcctcaa cctcgggact cataactacc agataatggc tactgagggt taccagtcgt     1140

caggatcttc agacattacg gtgtcaagag atgttgagac tggagaggtt ctctgggacc     1200

ctattgttgc tgtcgaaccg gccggtaagg cgagaacatt cgacttgcgc gttccaccct     1260

ttgcaaactt cgtgagcgag gacctggtgg tgcataactc tggtgtaaaa gttgctgtcc     1320

tcgatacagg gatatccact catccagatc taaatattcg tggtggcgca agctttgtac     1380

caggggaacc gtcgactcaa gatgggaatg ggcatggcac gcatgtggcc gggacgatcg     1440

ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  80
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T148

<400>  80
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc tgcctggccg      360

agggctcgct cgtcttggac gcggctaccg ggcagagggt ccctatcgaa aaggtgcgtc      420

cggggatgga agttttctcc ttgggacctg attacagact gtatcgggtg cccgttttgg      480

aggtccttga gagcggggtt agggaagttg tgcgcctcag aactcggtca gggagaacgc      540

tggtgttgac accagatcac ccgcttttga cccccgaagg ttggaaacct ctttgtgacc      600

tcccgcttgg aactccaatt gcagtcgccc aaacatgtct gaccagccca caaacaggat      660

tccacaacgg cttcttttac tcgttttgga aagattctcc tggtactgtt aacttttgcc      720

ttcttgaagg gggaagatat acctccaatt ggtctgggat aaacaattgg gtcggtggca      780

agggctggca gaccggtagt aggcgcaaca tcacgtattc cgggagcttc aatacaccag      840

ggaatggata cctggctctc tacggttgga ccaccaaccc gttggttgag tactatgttg      900

tcgatagctg gggctcctgg cgccctcccg gaagtgatgg gacatttctt ggcacagtga      960

actcagacgg cggcacgtat gacatctaca gggcgcaaag agtcaacgca ccgagcatca     1020

ttggcaatgc caccttctac cagtattggt ccgtgcggca gtccaagcgt gtcggtggga     1080

caatcacgac tggcaaccac ttcgacgcgt gggccagcgt gggcctcaac ctcgggactc     1140

ataactacca gataatggct actgagggtt accagtcgtc aggatcttca gacattacgg     1200

tgtcaagaga tgttgagact ggagaggttc tctgggaccc tattgttgct gtcgaaccgg     1260

ccggtaaggc gagaacattc gacttgcgcg ttccaccctt tgcaaacttc gtgagcgagg     1320

acctggtggt gcataacact catccagatc taaatattcg tggtggcgca agctttgtac     1380

caggggaacc gtcgactcaa gatgggaatg ggcatggcac gcatgtggcc gggacgatcg     1440

ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  81
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S166

<400>  81
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtgcctg gccgagggct      420

cgctcgtctt ggacgcggct accgggcaga gggtccctat cgaaaaggtg cgtccgggga      480

tggaagtttt ctccttggga cctgattaca gactgtatcg ggtgcccgtt ttggaggtcc      540

ttgagagcgg ggttagggaa gttgtgcgcc tcagaactcg gtcagggaga acgctggtgt      600

tgacaccaga tcacccgctt ttgacccccg aaggttggaa acctctttgt gacctcccgc      660

ttggaactcc aattgcagtc gcccaaacat gtctgaccag cccacaaaca ggattccaca      720

acggcttctt ttactcgttt tggaaagatt ctcctggtac tgttaacttt tgccttcttg      780

aagggggaag atatacctcc aattggtctg ggataaacaa ttgggtcggt ggcaagggct      840

ggcagaccgg tagtaggcgc aacatcacgt attccgggag cttcaataca ccagggaatg      900

gatacctggc tctctacggt tggaccacca acccgttggt tgagtactat gttgtcgata      960

gctggggctc ctggcgccct cccggaagtg atgggacatt tcttggcaca gtgaactcag     1020

acggcggcac gtatgacatc tacagggcgc aaagagtcaa cgcaccgagc atcattggca     1080

atgccacctt ctaccagtat tggtccgtgc ggcagtccaa gcgtgtcggt gggacaatca     1140

cgactggcaa ccacttcgac gcgtgggcca gcgtgggcct caacctcggg actcataact     1200

accagataat ggctactgag ggttaccagt cgtcaggatc ttcagacatt acggtgtcaa     1260

gagatgttga gactggagag gttctctggg accctattgt tgctgtcgaa ccggccggta     1320

aggcgagaac attcgacttg cgcgttccac cctttgcaaa cttcgtgagc gaggacctgg     1380

tggtgcataa ctcgactcaa gatgggaatg ggcatggcac gcatgtggcc gggacgatcg     1440

ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  82
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T167

<400>  82
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgtgc ctggccgagg      420

gctcgctcgt cttggacgcg gctaccgggc agagggtccc tatcgaaaag gtgcgtccgg      480

ggatggaagt tttctccttg ggacctgatt acagactgta tcgggtgccc gttttggagg      540

tccttgagag cggggttagg gaagttgtgc gcctcagaac tcggtcaggg agaacgctgg      600

tgttgacacc agatcacccg cttttgaccc ccgaaggttg gaaacctctt tgtgacctcc      660

cgcttggaac tccaattgca gtcgcccaaa catgtctgac cagcccacaa acaggattcc      720

acaacggctt cttttactcg ttttggaaag attctcctgg tactgttaac ttttgccttc      780

ttgaaggggg aagatatacc tccaattggt ctgggataaa caattgggtc ggtggcaagg      840

gctggcagac cggtagtagg cgcaacatca cgtattccgg gagcttcaat acaccaggga      900

atggatacct ggctctctac ggttggacca ccaacccgtt ggttgagtac tatgttgtcg      960

atagctgggg ctcctggcgc cctcccggaa gtgatgggac atttcttggc acagtgaact     1020

cagacggcgg cacgtatgac atctacaggg cgcaaagagt caacgcaccg agcatcattg     1080

gcaatgccac cttctaccag tattggtccg tgcggcagtc caagcgtgtc ggtgggacaa     1140

tcacgactgg caaccacttc gacgcgtggg ccagcgtggg cctcaacctc gggactcata     1200

actaccagat aatggctact gagggttacc agtcgtcagg atcttcagac attacggtgt     1260

caagagatgt tgagactgga gaggttctct gggaccctat tgttgctgtc gaaccggccg     1320

gtaaggcgag aacattcgac ttgcgcgttc caccctttgc aaacttcgtg agcgaggacc     1380

tggtggtgca taacactcaa gatgggaatg ggcatggcac gcatgtggcc gggacgatcg     1440

ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  83
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S196

<400>  83
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgact caagatggga      420

atgggcatgg cacgcatgtg gccgggacga tcgctgcttt aaacaattcg attggcgttc      480

ttggcgtagc gccgtgcctg gccgagggct cgctcgtctt ggacgcggct accgggcaga      540

gggtccctat cgaaaaggtg cgtccgggga tggaagtttt ctccttggga cctgattaca      600

gactgtatcg ggtgcccgtt ttggaggtcc ttgagagcgg ggttagggaa gttgtgcgcc      660

tcagaactcg gtcagggaga acgctggtgt tgacaccaga tcacccgctt ttgacccccg      720

aaggttggaa acctctttgt gacctcccgc ttggaactcc aattgcagtc gcccaaacat      780

gtctgaccag cccacaaaca ggattccaca acggcttctt ttactcgttt tggaaagatt      840

ctcctggtac tgttaacttt tgccttcttg aagggggaag atatacctcc aattggtctg      900

ggataaacaa ttgggtcggt ggcaagggct ggcagaccgg tagtaggcgc aacatcacgt      960

attccgggag cttcaataca ccagggaatg gatacctggc tctctacggt tggaccacca     1020

acccgttggt tgagtactat gttgtcgata gctggggctc ctggcgccct cccggaagtg     1080

atgggacatt tcttggcaca gtgaactcag acggcggcac gtatgacatc tacagggcgc     1140

aaagagtcaa cgcaccgagc atcattggca atgccacctt ctaccagtat tggtccgtgc     1200

ggcagtccaa gcgtgtcggt gggacaatca cgactggcaa ccacttcgac gcgtgggcca     1260

gcgtgggcct caacctcggg actcataact accagataat ggctactgag ggttaccagt     1320

cgtcaggatc ttcagacatt acggtgtcaa gagatgttga gactggagag gttctctggg     1380

accctattgt tgctgtcgaa ccggccggta aggcgagaac attcgacttg cgcgttccac     1440

cctttgcaaa cttcgtgagc gaggacctgg tggtgcataa cagcgctgag ctatacgctg     1500

ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  84
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial construct ProSavinase S208

<400>  84
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgact caagatggga      420

atgggcatgg cacgcatgtg gccgggacga tcgctgcttt aaacaattcg attggcgttc      480

ttggcgtagc gccgagcgct gagctatacg ctgttaaagt cctaggggcg tgcctggccg      540

agggctcgct cgtcttggac gcggctaccg ggcagagggt ccctatcgaa aaggtgcgtc      600

cggggatgga agttttctcc ttgggacctg attacagact gtatcgggtg cccgttttgg      660

aggtccttga gagcggggtt agggaagttg tgcgcctcag aactcggtca gggagaacgc      720

tggtgttgac accagatcac ccgcttttga cccccgaagg ttggaaacct ctttgtgacc      780

tcccgcttgg aactccaatt gcagtcgccc aaacatgtct gaccagccca caaacaggat      840

tccacaacgg cttcttttac tcgttttgga aagattctcc tggtactgtt aacttttgcc      900

ttcttgaagg gggaagatat acctccaatt ggtctgggat aaacaattgg gtcggtggca      960

agggctggca gaccggtagt aggcgcaaca tcacgtattc cgggagcttc aatacaccag     1020

ggaatggata cctggctctc tacggttgga ccaccaaccc gttggttgag tactatgttg     1080

tcgatagctg gggctcctgg cgccctcccg gaagtgatgg gacatttctt ggcacagtga     1140

actcagacgg cggcacgtat gacatctaca gggcgcaaag agtcaacgca ccgagcatca     1200

ttggcaatgc caccttctac cagtattggt ccgtgcggca gtccaagcgt gtcggtggga     1260

caatcacgac tggcaaccac ttcgacgcgt gggccagcgt gggcctcaac ctcgggactc     1320

ataactacca gataatggct actgagggtt accagtcgtc aggatcttca gacattacgg     1380

tgtcaagaga tgttgagact ggagaggttc tctgggaccc tattgttgct gtcgaaccgg     1440

ccggtaaggc gagaacattc gacttgcgcg ttccaccctt tgcaaacttc gtgagcgagg     1500

acctggtggt gcataacagc ggttcaggtt cggtcagctc gattgcccaa ggattggaat     1560

gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  85
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S239

<400>  85
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgact caagatggga      420

atgggcatgg cacgcatgtg gccgggacga tcgctgcttt aaacaattcg attggcgttc      480

ttggcgtagc gccgagcgct gagctatacg ctgttaaagt cctaggggcg agcggttcag      540

gttcggtcag ctcgattgcc caaggattgg aatgggcagg gaacaatggc atgcacgttg      600

ctaatttgag tttaggaagc ccttgcctgg ccgagggctc gctcgtcttg gacgcggcta      660

ccgggcagag ggtccctatc gaaaaggtgc gtccggggat ggaagttttc tccttgggac      720

ctgattacag actgtatcgg gtgcccgttt tggaggtcct tgagagcggg gttagggaag      780

ttgtgcgcct cagaactcgg tcagggagaa cgctggtgtt gacaccagat cacccgcttt      840

tgacccccga aggttggaaa cctctttgtg acctcccgct tggaactcca attgcagtcg      900

cccaaacatg tctgaccagc ccacaaacag gattccacaa cggcttcttt tactcgtttt      960

ggaaagattc tcctggtact gttaactttt gccttcttga agggggaaga tatacctcca     1020

attggtctgg gataaacaat tgggtcggtg gcaagggctg gcagaccggt agtaggcgca     1080

acatcacgta ttccgggagc ttcaatacac cagggaatgg atacctggct ctctacggtt     1140

ggaccaccaa cccgttggtt gagtactatg ttgtcgatag ctggggctcc tggcgccctc     1200

ccggaagtga tgggacattt cttggcacag tgaactcaga cggcggcacg tatgacatct     1260

acagggcgca aagagtcaac gcaccgagca tcattggcaa tgccaccttc taccagtatt     1320

ggtccgtgcg gcagtccaag cgtgtcggtg ggacaatcac gactggcaac cacttcgacg     1380

cgtgggccag cgtgggcctc aacctcggga ctcataacta ccagataatg gctactgagg     1440

gttaccagtc gtcaggatct tcagacatta cggtgtcaag agatgttgag actggagagg     1500

ttctctggga ccctattgtt gctgtcgaac cggccggtaa ggcgagaaca ttcgacttgc     1560

gcgttccacc ctttgcaaac ttcgtgagcg aggacctggt ggtgcataac tcgccaagtg     1620

ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  86
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T243

<400>  86
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgact caagatggga      420

atgggcatgg cacgcatgtg gccgggacga tcgctgcttt aaacaattcg attggcgttc      480

ttggcgtagc gccgagcgct gagctatacg ctgttaaagt cctaggggcg agcggttcag      540

gttcggtcag ctcgattgcc caaggattgg aatgggcagg gaacaatggc atgcacgttg      600

ctaatttgag tttaggaagc ccttcgccaa gtgcctgcct ggccgagggc tcgctcgtct      660

tggacgcggc taccgggcag agggtcccta tcgaaaaggt gcgtccgggg atggaagttt      720

tctccttggg acctgattac agactgtatc gggtgcccgt tttggaggtc cttgagagcg      780

gggttaggga agttgtgcgc ctcagaactc ggtcagggag aacgctggtg ttgacaccag      840

atcacccgct tttgaccccc gaaggttgga aacctctttg tgacctcccg cttggaactc      900

caattgcagt cgcccaaaca tgtctgacca gcccacaaac aggattccac aacggcttct      960

tttactcgtt ttggaaagat tctcctggta ctgttaactt ttgccttctt gaagggggaa     1020

gatatacctc caattggtct gggataaaca attgggtcgg tggcaagggc tggcagaccg     1080

gtagtaggcg caacatcacg tattccggga gcttcaatac accagggaat ggatacctgg     1140

ctctctacgg ttggaccacc aacccgttgg ttgagtacta tgttgtcgat agctggggct     1200

cctggcgccc tcccggaagt gatgggacat ttcttggcac agtgaactca gacggcggca     1260

cgtatgacat ctacagggcg caaagagtca acgcaccgag catcattggc aatgccacct     1320

tctaccagta ttggtccgtg cggcagtcca agcgtgtcgg tgggacaatc acgactggca     1380

accacttcga cgcgtgggcc agcgtgggcc tcaacctcgg gactcataac taccagataa     1440

tggctactga gggttaccag tcgtcaggat cttcagacat tacggtgtca agagatgttg     1500

agactggaga ggttctctgg gaccctattg ttgctgtcga accggccggt aaggcgagaa     1560

cattcgactt gcgcgttcca ccctttgcaa acttcgtgag cgaggacctg gtggtgcata     1620

acacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt gtagcggcat     1680

ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  87
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S269

<400>  87
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgact caagatggga      420

atgggcatgg cacgcatgtg gccgggacga tcgctgcttt aaacaattcg attggcgttc      480

ttggcgtagc gccgagcgct gagctatacg ctgttaaagt cctaggggcg agcggttcag      540

gttcggtcag ctcgattgcc caaggattgg aatgggcagg gaacaatggc atgcacgttg      600

ctaatttgag tttaggaagc ccttcgccaa gtgccacact tgagcaagct gttaatagcg      660

cgacttctag aggcgttctt gttgtagcgg catctgggaa ctcaggtgca ggctgcctgg      720

ccgagggctc gctcgtcttg gacgcggcta ccgggcagag ggtccctatc gaaaaggtgc      780

gtccggggat ggaagttttc tccttgggac ctgattacag actgtatcgg gtgcccgttt      840

tggaggtcct tgagagcggg gttagggaag ttgtgcgcct cagaactcgg tcagggagaa      900

cgctggtgtt gacaccagat cacccgcttt tgacccccga aggttggaaa cctctttgtg      960

acctcccgct tggaactcca attgcagtcg cccaaacatg tctgaccagc ccacaaacag     1020

gattccacaa cggcttcttt tactcgtttt ggaaagattc tcctggtact gttaactttt     1080

gccttcttga agggggaaga tatacctcca attggtctgg gataaacaat tgggtcggtg     1140

gcaagggctg gcagaccggt agtaggcgca acatcacgta ttccgggagc ttcaatacac     1200

cagggaatgg atacctggct ctctacggtt ggaccaccaa cccgttggtt gagtactatg     1260

ttgtcgatag ctggggctcc tggcgccctc ccggaagtga tgggacattt cttggcacag     1320

tgaactcaga cggcggcacg tatgacatct acagggcgca aagagtcaac gcaccgagca     1380

tcattggcaa tgccaccttc taccagtatt ggtccgtgcg gcagtccaag cgtgtcggtg     1440

ggacaatcac gactggcaac cacttcgacg cgtgggccag cgtgggcctc aacctcggga     1500

ctcataacta ccagataatg gctactgagg gttaccagtc gtcaggatct tcagacatta     1560

cggtgtcaag agatgttgag actggagagg ttctctggga ccctattgtt gctgtcgaac     1620

cggccggtaa ggcgagaaca ttcgacttgc gcgttccacc ctttgcaaac ttcgtgagcg     1680

aggacctggt ggtgcataac tcaatcagct atccggcgcg ctatgcgaac gcaatggcag     1740

tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  88
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T285

<400>  88
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgact caagatggga      420

atgggcatgg cacgcatgtg gccgggacga tcgctgcttt aaacaattcg attggcgttc      480

ttggcgtagc gccgagcgct gagctatacg ctgttaaagt cctaggggcg agcggttcag      540

gttcggtcag ctcgattgcc caaggattgg aatgggcagg gaacaatggc atgcacgttg      600

ctaatttgag tttaggaagc ccttcgccaa gtgccacact tgagcaagct gttaatagcg      660

cgacttctag aggcgttctt gttgtagcgg catctgggaa ctcaggtgca ggctcaatca      720

gctatccggc gcgctatgcg aacgcaatgg cagtcggagc ttgcctggcc gagggctcgc      780

tcgtcttgga cgcggctacc gggcagaggg tccctatcga aaaggtgcgt ccggggatgg      840

aagttttctc cttgggacct gattacagac tgtatcgggt gcccgttttg gaggtccttg      900

agagcggggt tagggaagtt gtgcgcctca gaactcggtc agggagaacg ctggtgttga      960

caccagatca cccgcttttg acccccgaag gttggaaacc tctttgtgac ctcccgcttg     1020

gaactccaat tgcagtcgcc caaacatgtc tgaccagccc acaaacagga ttccacaacg     1080

gcttctttta ctcgttttgg aaagattctc ctggtactgt taacttttgc cttcttgaag     1140

ggggaagata tacctccaat tggtctggga taaacaattg ggtcggtggc aagggctggc     1200

agaccggtag taggcgcaac atcacgtatt ccgggagctt caatacacca gggaatggat     1260

acctggctct ctacggttgg accaccaacc cgttggttga gtactatgtt gtcgatagct     1320

ggggctcctg gcgccctccc ggaagtgatg ggacatttct tggcacagtg aactcagacg     1380

gcggcacgta tgacatctac agggcgcaaa gagtcaacgc accgagcatc attggcaatg     1440

ccaccttcta ccagtattgg tccgtgcggc agtccaagcg tgtcggtggg acaatcacga     1500

ctggcaacca cttcgacgcg tgggccagcg tgggcctcaa cctcgggact cataactacc     1560

agataatggc tactgagggt taccagtcgt caggatcttc agacattacg gtgtcaagag     1620

atgttgagac tggagaggtt ctctgggacc ctattgttgc tgtcgaaccg gccggtaagg     1680

cgagaacatt cgacttgcgc gttccaccct ttgcaaactt cgtgagcgag gacctggtgg     1740

tgcataacac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  89
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S293

<400>  89
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgact caagatggga      420

atgggcatgg cacgcatgtg gccgggacga tcgctgcttt aaacaattcg attggcgttc      480

ttggcgtagc gccgagcgct gagctatacg ctgttaaagt cctaggggcg agcggttcag      540

gttcggtcag ctcgattgcc caaggattgg aatgggcagg gaacaatggc atgcacgttg      600

ctaatttgag tttaggaagc ccttcgccaa gtgccacact tgagcaagct gttaatagcg      660

cgacttctag aggcgttctt gttgtagcgg catctgggaa ctcaggtgca ggctcaatca      720

gctatccggc gcgctatgcg aacgcaatgg cagtcggagc tactgatcaa aacaacaacc      780

gcgcttgcct ggccgagggc tcgctcgtct tggacgcggc taccgggcag agggtcccta      840

tcgaaaaggt gcgtccgggg atggaagttt tctccttggg acctgattac agactgtatc      900

gggtgcccgt tttggaggtc cttgagagcg gggttaggga agttgtgcgc ctcagaactc      960

ggtcagggag aacgctggtg ttgacaccag atcacccgct tttgaccccc gaaggttgga     1020

aacctctttg tgacctcccg cttggaactc caattgcagt cgcccaaaca tgtctgacca     1080

gcccacaaac aggattccac aacggcttct tttactcgtt ttggaaagat tctcctggta     1140

ctgttaactt ttgccttctt gaagggggaa gatatacctc caattggtct gggataaaca     1200

attgggtcgg tggcaagggc tggcagaccg gtagtaggcg caacatcacg tattccggga     1260

gcttcaatac accagggaat ggatacctgg ctctctacgg ttggaccacc aacccgttgg     1320

ttgagtacta tgttgtcgat agctggggct cctggcgccc tcccggaagt gatgggacat     1380

ttcttggcac agtgaactca gacggcggca cgtatgacat ctacagggcg caaagagtca     1440

acgcaccgag catcattggc aatgccacct tctaccagta ttggtccgtg cggcagtcca     1500

agcgtgtcgg tgggacaatc acgactggca accacttcga cgcgtgggcc agcgtgggcc     1560

tcaacctcgg gactcataac taccagataa tggctactga gggttaccag tcgtcaggat     1620

cttcagacat tacggtgtca agagatgttg agactggaga ggttctctgg gaccctattg     1680

ttgctgtcga accggccggt aaggcgagaa cattcgactt gcgcgttcca ccctttgcaa     1740

acttcgtgag cgaggacctg gtggtgcata acagcttttc acagtatggc gcaggccttg     1800

acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  90
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S317

<400>  90
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgact caagatggga      420

atgggcatgg cacgcatgtg gccgggacga tcgctgcttt aaacaattcg attggcgttc      480

ttggcgtagc gccgagcgct gagctatacg ctgttaaagt cctaggggcg agcggttcag      540

gttcggtcag ctcgattgcc caaggattgg aatgggcagg gaacaatggc atgcacgttg      600

ctaatttgag tttaggaagc ccttcgccaa gtgccacact tgagcaagct gttaatagcg      660

cgacttctag aggcgttctt gttgtagcgg catctgggaa ctcaggtgca ggctcaatca      720

gctatccggc gcgctatgcg aacgcaatgg cagtcggagc tactgatcaa aacaacaacc      780

gcgctagctt ttcacagtat ggcgcaggcc ttgacattgt cgcacccggg gtaaacgtgc      840

agagcacata cccaggttgc ctggccgagg gctcgctcgt cttggacgcg gctaccgggc      900

agagggtccc tatcgaaaag gtgcgtccgg ggatggaagt tttctccttg ggacctgatt      960

acagactgta tcgggtgccc gttttggagg tccttgagag cggggttagg gaagttgtgc     1020

gcctcagaac tcggtcaggg agaacgctgg tgttgacacc agatcacccg cttttgaccc     1080

ccgaaggttg gaaacctctt tgtgacctcc cgcttggaac tccaattgca gtcgcccaaa     1140

catgtctgac cagcccacaa acaggattcc acaacggctt cttttactcg ttttggaaag     1200

attctcctgg tactgttaac ttttgccttc ttgaaggggg aagatatacc tccaattggt     1260

ctgggataaa caattgggtc ggtggcaagg gctggcagac cggtagtagg cgcaacatca     1320

cgtattccgg gagcttcaat acaccaggga atggatacct ggctctctac ggttggacca     1380

ccaacccgtt ggttgagtac tatgttgtcg atagctgggg ctcctggcgc cctcccggaa     1440

gtgatgggac atttcttggc acagtgaact cagacggcgg cacgtatgac atctacaggg     1500

cgcaaagagt caacgcaccg agcatcattg gcaatgccac cttctaccag tattggtccg     1560

tgcggcagtc caagcgtgtc ggtgggacaa tcacgactgg caaccacttc gacgcgtggg     1620

ccagcgtggg cctcaacctc gggactcata actaccagat aatggctact gagggttacc     1680

agtcgtcagg atcttcagac attacggtgt caagagatgt tgagactgga gaggttctct     1740

gggaccctat tgttgctgtc gaaccggccg gtaaggcgag aacattcgac ttgcgcgttc     1800

caccctttgc aaacttcgtg agcgaggacc tggtggtgca taactcaaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  91
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T318

<400>  91
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgact caagatggga      420

atgggcatgg cacgcatgtg gccgggacga tcgctgcttt aaacaattcg attggcgttc      480

ttggcgtagc gccgagcgct gagctatacg ctgttaaagt cctaggggcg agcggttcag      540

gttcggtcag ctcgattgcc caaggattgg aatgggcagg gaacaatggc atgcacgttg      600

ctaatttgag tttaggaagc ccttcgccaa gtgccacact tgagcaagct gttaatagcg      660

cgacttctag aggcgttctt gttgtagcgg catctgggaa ctcaggtgca ggctcaatca      720

gctatccggc gcgctatgcg aacgcaatgg cagtcggagc tactgatcaa aacaacaacc      780

gcgctagctt ttcacagtat ggcgcaggcc ttgacattgt cgcacccggg gtaaacgtgc      840

agagcacata cccaggttca tgcctggccg agggctcgct cgtcttggac gcggctaccg      900

ggcagagggt ccctatcgaa aaggtgcgtc cggggatgga agttttctcc ttgggacctg      960

attacagact gtatcgggtg cccgttttgg aggtccttga gagcggggtt agggaagttg     1020

tgcgcctcag aactcggtca gggagaacgc tggtgttgac accagatcac ccgcttttga     1080

cccccgaagg ttggaaacct ctttgtgacc tcccgcttgg aactccaatt gcagtcgccc     1140

aaacatgtct gaccagccca caaacaggat tccacaacgg cttcttttac tcgttttgga     1200

aagattctcc tggtactgtt aacttttgcc ttcttgaagg gggaagatat acctccaatt     1260

ggtctgggat aaacaattgg gtcggtggca agggctggca gaccggtagt aggcgcaaca     1320

tcacgtattc cgggagcttc aatacaccag ggaatggata cctggctctc tacggttgga     1380

ccaccaaccc gttggttgag tactatgttg tcgatagctg gggctcctgg cgccctcccg     1440

gaagtgatgg gacatttctt ggcacagtga actcagacgg cggcacgtat gacatctaca     1500

gggcgcaaag agtcaacgca ccgagcatca ttggcaatgc caccttctac cagtattggt     1560

ccgtgcggca gtccaagcgt gtcggtggga caatcacgac tggcaaccac ttcgacgcgt     1620

gggccagcgt gggcctcaac ctcgggactc ataactacca gataatggct actgagggtt     1680

accagtcgtc aggatcttca gacattacgg tgtcaagaga tgttgagact ggagaggttc     1740

tctgggaccc tattgttgct gtcgaaccgg ccggtaaggc gagaacattc gacttgcgcg     1800

ttccaccctt tgcaaacttc gtgagcgagg acctggtggt gcataacaca tatgccagct     1860

taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  92
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T329

<400>  92
caaaagaaaa atatttaatt ggctttaatg agcaggaagc tgtcagtgag tttgtagaac       60

aagtagaggc aaatgacgag gtcgccattc tctctgagga agaggaagtc gaaattgaat      120

tgcttcatga atttgaaacg attcctgttt tatccgttga gttaagccca gaagatgtgg      180

acgcgcttga actcgatcca gcgatttctt atattgaaga ggatgcagaa gtaacgacaa      240

tggcgcaatc ggtaccatgg ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg      300

gattgacagg ttctggtgta aaagttgctg tcctcgatac agggatatcc actcatccag      360

atctaaatat tcgtggtggc gcaagctttg taccagggga accgtcgact caagatggga      420

atgggcatgg cacgcatgtg gccgggacga tcgctgcttt aaacaattcg attggcgttc      480

ttggcgtagc gccgagcgct gagctatacg ctgttaaagt cctaggggcg agcggttcag      540

gttcggtcag ctcgattgcc caaggattgg aatgggcagg gaacaatggc atgcacgttg      600

ctaatttgag tttaggaagc ccttcgccaa gtgccacact tgagcaagct gttaatagcg      660

cgacttctag aggcgttctt gttgtagcgg catctgggaa ctcaggtgca ggctcaatca      720

gctatccggc gcgctatgcg aacgcaatgg cagtcggagc tactgatcaa aacaacaacc      780

gcgctagctt ttcacagtat ggcgcaggcc ttgacattgt cgcacccggg gtaaacgtgc      840

agagcacata cccaggttca acatatgcca gcttaaacgg tacatcgatg gcttgcctgg      900

ccgagggctc gctcgtcttg gacgcggcta ccgggcagag ggtccctatc gaaaaggtgc      960

gtccggggat ggaagttttc tccttgggac ctgattacag actgtatcgg gtgcccgttt     1020

tggaggtcct tgagagcggg gttagggaag ttgtgcgcct cagaactcgg tcagggagaa     1080

cgctggtgtt gacaccagat cacccgcttt tgacccccga aggttggaaa cctctttgtg     1140

acctcccgct tggaactcca attgcagtcg cccaaacatg tctgaccagc ccacaaacag     1200

gattccacaa cggcttcttt tactcgtttt ggaaagattc tcctggtact gttaactttt     1260

gccttcttga agggggaaga tatacctcca attggtctgg gataaacaat tgggtcggtg     1320

gcaagggctg gcagaccggt agtaggcgca acatcacgta ttccgggagc ttcaatacac     1380

cagggaatgg atacctggct ctctacggtt ggaccaccaa cccgttggtt gagtactatg     1440

ttgtcgatag ctggggctcc tggcgccctc ccggaagtga tgggacattt cttggcacag     1500

tgaactcaga cggcggcacg tatgacatct acagggcgca aagagtcaac gcaccgagca     1560

tcattggcaa tgccaccttc taccagtatt ggtccgtgcg gcagtccaag cgtgtcggtg     1620

ggacaatcac gactggcaac cacttcgacg cgtgggccag cgtgggcctc aacctcggga     1680

ctcataacta ccagataatg gctactgagg gttaccagtc gtcaggatct tcagacatta     1740

cggtgtcaag agatgttgag actggagagg ttctctggga ccctattgtt gctgtcgaac     1800

cggccggtaa ggcgagaaca ttcgacttgc gcgttccacc ctttgcaaac ttcgtgagcg     1860

aggacctggt ggtgcataac actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa     1920

agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg gcaactagtt     1980

taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca acgcgttaag     2040

acgtcgcgc                                                             2049


<210>  93
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct NI-1

<400>  93
atggctcagc cagctaagaa cgtggagaag gattacatcg tcggcttcaa gagcggcgtc       60

aagacagctt ctgttaagaa ggacatcatt aaggagagcg gcggcaaggt tgataagcaa      120

ttcagaatca ttaacgcggc caaggctaag ctcgacaagg aggcgcttaa ggaggtgaag      180

aatgacccgg atgttgccta cgtggaggag gatcacgtcg cccatgctct ggcgcagtgc      240

ctttctttcg gaactgagat ccttaccgtt gagtacggac cacttcctat tggtaagatc      300

gtttctgagg aaattaactg ctcagtgtac tctgttgatc cagaaggaag agtttacact      360

caggctatcg cacaatggca cgataggggt gaacaagagg ttctcgagta cgagcttgaa      420

gatggatccg ttattcgtgc tacctctgac catagattct tgactacaga ttatcagctt      480

ctcgctatcg aggaaatctt tgctaggcaa cttgatctcc ttactttgga gaacatcaag      540

cagacagaag aggctcttga caaccacaga cttccattcc ctttgctcga tgctggaacc      600

atcaagtga                                                              609


<210>  94
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct IC-1

<400>  94
atggttaagg tgattggaag acgttctctt ggtgttcaaa ggatcttcga tatcggattg       60

ccacaagacc acaactttct tctcgctaat ggtgccatcg ctgccaattg cactgttccg      120

tacggcatcc cactcattaa ggccgacaag gtgcaggctc aaggcttcaa gggcgcgaac      180

gtgaaggtcg ccgttcttga caccggcatc caagcttcac accctgatct gaatgtggtc      240

ggaggagctt cgttcgtcgc tggagaggcc tacaacactg acggaaatgg ccacggcacc      300

catgtggctg gcactgtcgc tgcgcttgat aacaccactg gagtcctggg cgttgctcca      360

tcagtgtcgc tgtacgctgt gaaggtcctc aactccagcg gctccggcag ctactctggc      420

atcgtgtctg gcattgagtg ggctacaacg aacggcatgg acgtcattaa tatgagcctc      480

ggcggagctt caggatcgac cgcgatgaag caggccgtcg ataacgccta cgctagaggc      540

gttgtggtcg ttgccgctgc gggcaattcc ggctcttcag gcaacaccaa tactatcggc      600

tacccggcca agtacgactc tgtgattgct gtcggcgcgg ttgattccaa cagcaatcgg      660

gcgtcattct cgtccgttgg agctgagctc gaggtcatgg ctcctggagc tggcgtgtac      720

tccacctacc ccacaaacac gtacgcgaca cttaatggca cgtcgatggt ttccccacac      780

gtggctggag ctgctgctct gatcctcagc aagcatccaa acctgtctgc ctcacaggtc      840

aggaatcgcc tcagctctac cgctacttac cttggctcat cgttctacta cggcaagggc      900

ctcattaacg ttgaggccgc tgcgcaatga                                       930


<210>  95
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct NI-2

<400>  95
atggtggaga aggattacat cgtcggcttc aagagcggcg tcaagacagc ttctgttaag       60

aaggacatca ttaaggagag cggcggcaag gttgataagc aattcagaat cattaacgcg      120

gccaaggcta agctcgacaa ggaggcgctt aaggaggtga agaatgaccc ggatgttgcc      180

tacgtggagg aggatcacgt cgcccatgct ctggcgcaga ctgttccgta cggcatccca      240

ctcattaagg ccgacaaggt gcaggctcaa ggcttcaagg gcgcgaacgt gaaggtcgcc      300

gttcttgaca ccggcatcca agcttcacac cctgatctga atgtggtcgg aggagcttgc      360

ctttctttcg gaactgagat ccttaccgtt gagtacggac cacttcctat tggtaagatc      420

gtttctgagg aaattaactg ctcagtgtac tctgttgatc cagaaggaag agtttacact      480

caggctatcg cacaatggca cgataggggt gaacaagagg ttctcgagta cgagcttgaa      540

gatggatccg ttattcgtgc tacctctgac catagattct tgactacaga ttatcagctt      600

ctcgctatcg aggaaatctt tgctaggcaa cttgatctcc ttactttgga gaacatcaag      660

cagacagaag aggctcttga caaccacaga cttccattcc ctttgctcga tgctggaacc      720

atcaagtga                                                              729


<210>  96
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct IC-2

<400>  96
atggttaagg tgattggaag acgttctctt ggtgttcaaa ggatcttcga tatcggattg       60

ccacaagacc acaactttct tctcgctaat ggtgccatcg ctgccaattg ctcgttcgtc      120

gctggagagg cctacaacac tgacggaaat ggccacggca cccatgtggc tggcactgtc      180

gctgcgcttg ataacaccac tggagtcctg ggcgttgctc catcagtgtc gctgtacgct      240

gtgaaggtcc tcaactccag cggctccggc agctactctg gcatcgtgtc tggcattgag      300

tgggctacaa cgaacggcat ggacgtcatt aatatgagcc tcggcggagc ttcaggatcg      360

accgcgatga agcaggccgt cgataacgcc tacgctagag gcgttgtggt cgttgccgct      420

gcgggcaatt ccggctcttc aggcaacacc aatactatcg gctacccggc caagtacgac      480

tctgtgattg ctgtcggcgc ggttgattcc aacagcaatc gggcgtcatt ctcgtccgtt      540

ggagctgagc tcgaggtcat ggctcctgga gctggcgtgt actccaccta ccccacaaac      600

acgtacgcga cacttaatgg cacgtcgatg gtttccccac acgtggctgg agctgctgct      660

ctgatcctca gcaagcatcc aaacctgtct gcctcacagg tcaggaatcg cctcagctct      720

accgctactt accttggctc atcgttctac tacggcaagg gcctcattaa cgttgaggcc      780

gctgcgcaat ga                                                          792


<210>  97
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct NI-3

<400>  97
atggctcagc cagctaagaa cgtggagaag gattacatcg tcggcttcaa gagcggcgtc       60

aagacagctt ctgttaagaa ggacatcatt aaggagagcg gcggcaaggt tgataagcaa      120

ttcagaatca ttaacgcggc caaggctaag ctcgacaagg aggcgcttaa ggaggtgaag      180

aatgacccgg atgttgccta cgtggaggag gatcacgtcg cccatgctct ggcgcagact      240

gttccgtacg gcatcccact cattaaggcc gacaaggtgc aggctcaagg cttcaagggc      300

gcgaacgtga aggtcgccgt tcttgacacc ggcatccaag cttcacaccc tgatctgaat      360

gtggtcggag gagcttcgtt cgtcgctgga gaggcctaca acactgacgg aaatggccac      420

ggcacccatg tggctggcac tgtcgctgcg cttgataaca ccactggagt cctgggcgtt      480

gctccatcag tgtcgctgta cgctgtgaag gtcctcaact ccagcggctc cggcagctac      540

tctggcatcg tgtctggcat tgagtgggct acaacgaacg gcatggacgt cattaatatg      600

agcctcggcg gagcttgcct ttctttcgga actgagatcc ttaccgttga gtacggacca      660

cttcctattg gtaagatcgt ttctgaggaa attaactgct cagtgtactc tgttgatcca      720

gaaggaagag tttacactca ggctatcgca caatggcacg ataggggtga acaagaggtt      780

ctcgagtacg agcttgaaga tggatccgtt attcgtgcta cctctgacca tagattcttg      840

actacagatt atcagcttct cgctatcgag gaaatctttg ctaggcaact tgatctcctt      900

actttggaga acatcaagca gacagaagag gctcttgaca accacagact tccattccct      960

ttgctcgatg ctggaaccat caagtga                                          987


<210>  98
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct IC-3

<400>  98
atggttaagg tgattggaag acgttctctt ggtgttcaaa ggatcttcga tatcggattg       60

ccacaagacc acaactttct tctcgctaat ggtgccatcg ctgccaattg ctcaggatcg      120

accgcgatga agcaggccgt cgataacgcc tacgctagag gcgttgtggt cgttgccgct      180

gcgggcaatt ccggctcttc aggcaacacc aatactatcg gctacccggc caagtacgac      240

tctgtgattg ctgtcggcgc ggttgattcc aacagcaatc gggcgtcatt ctcgtccgtt      300

ggagctgagc tcgaggtcat ggctcctgga gctggcgtgt actccaccta ccccacaaac      360

acgtacgcga cacttaatgg cacgtcgatg gtttccccac acgtggctgg agctgctgct      420

ctgatcctca gcaagcatcc aaacctgtct gcctcacagg tcaggaatcg cctcagctct      480

accgctactt accttggctc atcgttctac tacggcaagg gcctcattaa cgttgaggcc      540

gctgcgcaat ga                                                          552


<210>  99
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct NI-4

<400>  99
atggctcagc cagctaagaa cgtggagaag gattacatcg tcggcttcaa gagcggcgtc       60

aagacagctt ctgttaagaa ggacatcatt aaggagagcg gcggcaaggt tgataagcaa      120

ttcagaatca ttaacgcggc caaggctaag ctcgacaagg aggcgcttaa ggaggtgaag      180

aatgacccgg atgttgccta cgtggaggag gatcacgtcg cccatgctct ggcgcagact      240

gttccgtacg gcatcccact cattaaggcc gacaaggtgc aggctcaagg cttcaagggc      300

gcgaacgtga aggtcgccgt tcttgacacc ggcatccaag cttcacaccc tgatctgaat      360

gtggtcggag gagcttcgtt cgtcgctgga gaggcctaca acactgacgg aaatggccac      420

ggcacccatg tggctggcac tgtcgctgcg cttgataaca ccactggagt cctgggcgtt      480

gctccatcag tgtcgctgta cgctgtgaag gtcctcaact ccagcggctc cggcagctac      540

tctggcatcg tgtctggcat tgagtgggct acaacgaacg gcatggacgt cattaatatg      600

agcctcggcg gagcttcagg atcgaccgcg atgaagcagg ccgtcgataa cgcctacgct      660

agaggcgttg tggtcgttgc cgctgcgggc aattgccttt ctttcggaac tgagatcctt      720

accgttgagt acggaccact tcctattggt aagatcgttt ctgaggaaat taactgctca      780

gtgtactctg ttgatccaga aggaagagtt tacactcagg ctatcgcaca atggcacgat      840

aggggtgaac aagaggttct cgagtacgag cttgaagatg gatccgttat tcgtgctacc      900

tctgaccata gattcttgac tacagattat cagcttctcg ctatcgagga aatctttgct      960

aggcaacttg atctccttac tttggagaac atcaagcaga cagaagaggc tcttgacaac     1020

cacagacttc cattcccttt gctcgatgct ggaaccatca agtga                     1065


<210>  100
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct IC-4

<400>  100
atggttaagg tgattggaag acgttctctt ggtgttcaaa ggatcttcga tatcggattg       60

ccacaagacc acaactttct tctcgctaat ggtgccatcg ctgccaattg ctccggctct      120

tcaggcaaca ccaatactat cggctacccg gccaagtacg actctgtgat tgctgtcggc      180

gcggttgatt ccaacagcaa tcgggcgtca ttctcgtccg ttggagctga gctcgaggtc      240

atggctcctg gagctggcgt gtactccacc taccccacaa acacgtacgc gacacttaat      300

ggcacgtcga tggtttcccc acacgtggct ggagctgctg ctctgatcct cagcaagcat      360

ccaaacctgt ctgcctcaca ggtcaggaat cgcctcagct ctaccgctac ttaccttggc      420

tcatcgttct actacggcaa gggcctcatt aacgttgagg ccgctgcgca atga            474


<210>  101
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct NI-5

<400>  101
atggctcagc cagctaagaa cgtggagaag gattacatcg tcggcttcaa gagcggcgtc       60

aagacagctt ctgttaagaa ggacatcatt aaggagagcg gcggcaaggt tgataagcaa      120

ttcagaatca ttaacgcggc caaggctaag ctcgacaagg aggcgcttaa ggaggtgaag      180

aatgacccgg atgttgccta cgtggaggag gatcacgtcg cccatgctct ggcgcagact      240

gttccgtacg gcatcccact cattaaggcc gacaaggtgc aggctcaagg cttcaagggc      300

gcgaacgtga aggtcgccgt tcttgacacc ggcatccaag cttcacaccc tgatctgaat      360

gtggtcggag gagcttcgtt cgtcgctgga gaggcctaca acactgacgg aaatggccac      420

ggcacccatg tggctggcac tgtcgctgcg cttgataaca ccactggagt cctgggcgtt      480

gctccatcag tgtcgctgta cgctgtgaag gtcctcaact ccagcggctc cggcagctac      540

tctggcatcg tgtctggcat tgagtgggct acaacgaacg gcatggacgt cattaatatg      600

agcctcggcg gagcttcagg atcgaccgcg atgaagcagg ccgtcgataa cgcctacgct      660

agaggcgttg tggtcgttgc cgctgcgggc aattccggct cttgcctttc tttcggaact      720

gagatcctta ccgttgagta cggaccactt cctattggta agatcgtttc tgaggaaatt      780

aactgctcag tgtactctgt tgatccagaa ggaagagttt acactcaggc tatcgcacaa      840

tggcacgata ggggtgaaca agaggttctc gagtacgagc ttgaagatgg atccgttatt      900

cgtgctacct ctgaccatag attcttgact acagattatc agcttctcgc tatcgaggaa      960

atctttgcta ggcaacttga tctccttact ttggagaaca tcaagcagac agaagaggct     1020

cttgacaacc acagacttcc attccctttg ctcgatgctg gaaccatcaa gtga           1074


<210>  102
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct IC-5

<400>  102
atggttaagg tgattggaag acgttctctt ggtgttcaaa ggatcttcga tatcggattg       60

ccacaagacc acaactttct tctcgctaat ggtgccatcg ctgccaattg ctcaggcaac      120

accaatacta tcggctaccc ggccaagtac gactctgtga ttgctgtcgg cgcggttgat      180

tccaacagca atcgggcgtc attctcgtcc gttggagctg agctcgaggt catggctcct      240

ggagctggcg tgtactccac ctaccccaca aacacgtacg cgacacttaa tggcacgtcg      300

atggtttccc cacacgtggc tggagctgct gctctgatcc tcagcaagca tccaaacctg      360

tctgcctcac aggtcaggaa tcgcctcagc tctaccgcta cttaccttgg ctcatcgttc      420

tactacggca agggcctcat taacgttgag gccgctgcgc aatga                      465


<210>  103
<211>  1236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct NI-6

<400>  103
atggctcagc cagctaagaa cgtggagaag gattacatcg tcggcttcaa gagcggcgtc       60

aagacagctt ctgttaagaa ggacatcatt aaggagagcg gcggcaaggt tgataagcaa      120

ttcagaatca ttaacgcggc caaggctaag ctcgacaagg aggcgcttaa ggaggtgaag      180

aatgacccgg atgttgccta cgtggaggag gatcacgtcg cccatgctct ggcgcagact      240

gttccgtacg gcatcccact cattaaggcc gacaaggtgc aggctcaagg cttcaagggc      300

gcgaacgtga aggtcgccgt tcttgacacc ggcatccaag cttcacaccc tgatctgaat      360

gtggtcggag gagcttcgtt cgtcgctgga gaggcctaca acactgacgg aaatggccac      420

ggcacccatg tggctggcac tgtcgctgcg cttgataaca ccactggagt cctgggcgtt      480

gctccatcag tgtcgctgta cgctgtgaag gtcctcaact ccagcggctc cggcagctac      540

tctggcatcg tgtctggcat tgagtgggct acaacgaacg gcatggacgt cattaatatg      600

agcctcggcg gagcttcagg atcgaccgcg atgaagcagg ccgtcgataa cgcctacgct      660

agaggcgttg tggtcgttgc cgctgcgggc aattccggct cttcaggcaa caccaatact      720

atcggctacc cggccaagta cgactctgtg attgctgtcg gcgcggttga ttccaacagc      780

aatcgggcgt cattctcgtc cgttggagct gagctcgagg tcatggctcc tggagctggc      840

gtgtactcca cctaccccac aaactgcctt tctttcggaa ctgagatcct taccgttgag      900

tacggaccac ttcctattgg taagatcgtt tctgaggaaa ttaactgctc agtgtactct      960

gttgatccag aaggaagagt ttacactcag gctatcgcac aatggcacga taggggtgaa     1020

caagaggttc tcgagtacga gcttgaagat ggatccgtta ttcgtgctac ctctgaccat     1080

agattcttga ctacagatta tcagcttctc gctatcgagg aaatctttgc taggcaactt     1140

gatctcctta ctttggagaa catcaagcag acagaagagg ctcttgacaa ccacagactt     1200

ccattccctt tgctcgatgc tggaaccatc aagtga                               1236


<210>  104
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct IC-6

<400>  104
atggttaagg tgattggaag acgttctctt ggtgttcaaa ggatcttcga tatcggattg       60

ccacaagacc acaactttct tctcgctaat ggtgccatcg ctgccaattg cacgtacgcg      120

acacttaatg gcacgtcgat ggtttcccca cacgtggctg gagctgctgc tctgatcctc      180

agcaagcatc caaacctgtc tgcctcacag gtcaggaatc gcctcagctc taccgctact      240

taccttggct catcgttcta ctacggcaag ggcctcatta acgttgaggc cgctgcgcaa      300

tga                                                                    303


<210>  105
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct VMA codon optimized

<400>  105
tgctttgcca agggtaccaa tgttttaatg gcggatgggt ctattgaatg tattgaaaac       60

attgaggttg gtaataaggt catgggtaaa gatggcagac ctcgtgaggt aattaaattg      120

cccagaggaa gagaaactat gtacagcgtc gtgcagaaaa gtcagcacag agcccacaaa      180

agtgactcaa gtcgtgaagt gccagaatta ctcaagttta cgtgtaatgc gacccatgag      240

ttggttgtta gaacacctcg tagtgtccgc cgtttgtctc gtaccattaa gggtgtcgaa      300

tattttgaag ttattacttt tgagatgggc caaaagaaag cccccgacgg tagaattgtt      360

gagcttgtca aggaagtttc aaagagctac ccaatatctg aggggcctga gagagccaac      420

gaattagtag aatcctatag aaaggcttca aataaagctt attttgagtg gactattgag      480

gccagagatc tttctctgtt gggttcccat gttcgtaaag ctacctacca gacttacgct      540

ccaattcttt atgagaatga ccactttttc gactacatgc aaaaaagtaa gtttcatctc      600

accattgaag gtccaaaagt acttgcttat ttacttggtt tatggattgg tgatggattg      660

tctgacaggg caactttttc ggttgattcc agagatactt ctttgatgga acgtgttact      720

gaatatgctg aaaagttgaa tttgtgcgcc gagtataagg acagaaaaga accacaagtt      780

gccaaaactg ttaatttgta ctctaaagtt gtcagaggta atggtattcg caataatctt      840

aatactgaga atccattatg ggacgctatt gttggcttag gattcttgaa ggacggtgtc      900

aaaaatattc cttctttctt gtctacggac aatatcggta ctcgtgaaac atttcttgct      960

ggtctaattg attctgatgg ctatgttact gatgagcatg gtattaaagc aacaataaag     1020

acaattcata cttctgtcag agatggtttg gtttcccttg ctcgttcttt aggcttagta     1080

gtctcggtta acgcagaacc tgctaaggtt gacatgaatg gcaccaaaca taaaattagt     1140

tatgctattt atatgtctgg tggagatgtt ttgcttaacg ttctttcgaa gtgtgccggc     1200

tctaaaaaat tcaggcctgc tcccgccgct gcttttgcac gtgagtgccg cggattttat     1260

ttcgagttac aagaattgaa ggaagacgat tattatggga ttactttatc tgatgattct     1320

gatcatcagt ttttgcttgc caaccaggtt gtcgtccata at                        1362


<210>  106
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tth codon optimized

<400>  106
tgcctggccg agggctcgct cgtcttggac gcggctaccg ggcagagggt ccctatcgaa       60

aaggtgcgtc cggggatgga agttttctcc ttgggacctg attacagact gtatcgggtg      120

cccgttttgg aggtccttga gagcggggtt agggaagttg tgcgcctcag aactcggtca      180

gggagaacgc tggtgttgac accagatcac ccgcttttga cccccgaagg ttggaaacct      240

ctttgtgacc tcccgcttgg aactccaatt gcagtccccg cagaactgcc tgtggcgggc      300

cacttggccc cacctgaaga acgtgttacg ctcctggctc ttctgttggg ggatgggaac      360

acaaagctgt cgggtcggag aggtacacgt cctaatgcct tcttctacag caaagacccc      420

gaattgctcg cggcttatcg ccggtgtgca gaagccttgg gtgcaaaggt gaaagcatac      480

gtccacccga ctacgggggt ggttacactc gcaaccctcg ctccacgtcc tggagctcaa      540

gatcctgtca aacgcctcgt tgtcgaggcg ggaatggttg ctaaagccga agagaagagg      600

gtcccggagg aggtgtttcg ttaccggcgt gaggcgttgg cccttttctt gggccgtttg      660

ttctcgacag acggctctgt tgaaaagaag aggatctctt attcaagtgc cagtttggga      720

ctggcccagg atgtcgcaca tctcttgctg cgccttggaa ttacatctca actccgttcg      780

agagggccac gggctcacga ggttcttata tcgggccgcg aggatatttt gcggtttgct      840

gaacttatcg gaccctacct cttgggggcc aagagggaga gacttgcagc gctggaagct      900

gaggcccgca ggcgtttgcc tggacaggga tggcacttgc ggcttgttct tcctgccgtg      960

gcgtacagag tgagcgaggc taaaaggcgc tcgggatttt cgtggagtga agccggtcgg     1020

cgcgtcgcag ttgcgggatc gtgtttgtca tctggactca acctcaaatt gcccagacgc     1080

tacctttctc ggcaccggtt gtcgctgctc ggtgaggctt ttgccgaccc tgggctggaa     1140

gcgctcgcgg aaggccaagt gctctgggac cctattgttg ctgtcgaacc ggccggtaag     1200

gcgagaacat tcgacttgcg cgttccaccc tttgcaaact tcgtgagcga ggacctggtg     1260

gtgcataac                                                             1269


<210>  107
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct VMA1

<400>  107
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat gctttgccaa gggtaccaat      360

gttttaatgg cggatgggtc tattgaatgt attgaaaaca ttgaggttgg taataaggtc      420

atgggtaaag atggcagacc tcgtgaggta attaaattgc ccagaggaag agaaactatg      480

tacagcgtcg tgcagaaaag tcagcacaga gcccacaaaa gtgactcaag tcgtgaagtg      540

ccagaattac tcaagtttac gtgtaatgcg acccatgagt tggttgttag aacacctcgt      600

agtgtccgcc gtttgtctcg taccattaag ggtgtcgaat attttgaagt tattactttt      660

gagatgggcc aaaagaaagc ccccgacggt agaattgttg agcttgtcaa ggaagtttca      720

aagagctacc caatatctga ggggcctgag agagccaacg aattagtaga atcctataga      780

aaggcttcaa ataaagctta ttttgagtgg actattgagg ccagagatct ttctctgttg      840

ggttcccatg ttcgtaaagc tacctaccag acttacgctc caattcttta tgagaatgac      900

cactttttcg actacatgca aaaaagtaag tttcatctca ccattgaagg tccaaaagta      960

cttgcttatt tacttggttt atggattggt gatggattgt ctgacagggc aactttttcg     1020

gttgattcca gagatacttc tttgatggaa cgtgttactg aatatgctga aaagttgaat     1080

ttgtgcgccg agtataagga cagaaaagaa ccacaagttg ccaaaactgt taatttgtac     1140

tctaaagttg tcagaggtaa tggtattcgc aataatctta atactgagaa tccattatgg     1200

gacgctattg ttggcttagg attcttgaag gacggtgtca aaaatattcc ttctttcttg     1260

tctacggaca atatcggtac tcgtgaaaca tttcttgctg gtctaattga ttctgatggc     1320

tatgttactg atgagcatgg tattaaagca acaataaaga caattcatac ttctgtcaga     1380

gatggtttgg tttcccttgc tcgttcttta ggcttagtag tctcggttaa cgcagaacct     1440

gctaaggttg acatgaatgg caccaaacat aaaattagtt atgctattta tatgtctggt     1500

ggagatgttt tgcttaacgt tctttcgaag tgtgccggct ctaaaaaatt caggcctgct     1560

cccgccgctg cttttgcacg tgagtgccgc ggattttatt tcgagttaca agaattgaag     1620

gaagacgatt attatgggat tactttatct gatgattctg atcatcagtt tttgcttgcc     1680

aaccaggttg tcgtccataa ttcggtacca tggggaatta gccgtgtgca agccccagct     1740

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata     1800

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg     1860

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat     1920

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg     1980

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat     2040

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa     2100

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt     2160

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat     2220

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc     2280

ggggtaaacg tgcagagcac atacccaggt tcaacatatg ccagcttaaa cggtacatcg     2340

atggctactc ctcatgttgc aggtgcggcc gcccttgtta aacaaaagaa cccatcttgg     2400

tctaatgtac aaattcgaaa tcatctaaag aatacggcaa ctagtttagg aagcacgaac     2460

ttgtatggaa gcggacttgt taacgcagaa gcggcaacgc gttaa                     2505


<210>  108
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct VMA2

<400>  108
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc ctgctttgcc aagggtacca atgttttaat ggcggatggg      480

tctattgaat gtattgaaaa cattgaggtt ggtaataagg tcatgggtaa agatggcaga      540

cctcgtgagg taattaaatt gcccagagga agagaaacta tgtacagcgt cgtgcagaaa      600

agtcagcaca gagcccacaa aagtgactca agtcgtgaag tgccagaatt actcaagttt      660

acgtgtaatg cgacccatga gttggttgtt agaacacctc gtagtgtccg ccgtttgtct      720

cgtaccatta agggtgtcga atattttgaa gttattactt ttgagatggg ccaaaagaaa      780

gcccccgacg gtagaattgt tgagcttgtc aaggaagttt caaagagcta cccaatatct      840

gaggggcctg agagagccaa cgaattagta gaatcctata gaaaggcttc aaataaagct      900

tattttgagt ggactattga ggccagagat ctttctctgt tgggttccca tgttcgtaaa      960

gctacctacc agacttacgc tccaattctt tatgagaatg accacttttt cgactacatg     1020

caaaaaagta agtttcatct caccattgaa ggtccaaaag tacttgctta tttacttggt     1080

ttatggattg gtgatggatt gtctgacagg gcaacttttt cggttgattc cagagatact     1140

tctttgatgg aacgtgttac tgaatatgct gaaaagttga atttgtgcgc cgagtataag     1200

gacagaaaag aaccacaagt tgccaaaact gttaatttgt actctaaagt tgtcagaggt     1260

aatggtattc gcaataatct taatactgag aatccattat gggacgctat tgttggctta     1320

ggattcttga aggacggtgt caaaaatatt ccttctttct tgtctacgga caatatcggt     1380

actcgtgaaa catttcttgc tggtctaatt gattctgatg gctatgttac tgatgagcat     1440

ggtattaaag caacaataaa gacaattcat acttctgtca gagatggttt ggtttccctt     1500

gctcgttctt taggcttagt agtctcggtt aacgcagaac ctgctaaggt tgacatgaat     1560

ggcaccaaac ataaaattag ttatgctatt tatatgtctg gtggagatgt tttgcttaac     1620

gttctttcga agtgtgccgg ctctaaaaaa ttcaggcctg ctcccgccgc tgcttttgca     1680

cgtgagtgcc gcggatttta tttcgagtta caagaattga aggaagacga ttattatggg     1740

attactttat ctgatgattc tgatcatcag tttttgcttg ccaaccaggt tgtcgtccat     1800

aatactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg     1860

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat     1920

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg     1980

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat     2040

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa     2100

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt     2160

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat     2220

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc     2280

ggggtaaacg tgcagagcac atacccaggt tcaacatatg ccagcttaaa cggtacatcg     2340

atggctactc ctcatgttgc aggtgcggcc gcccttgtta aacaaaagaa cccatcttgg     2400

tctaatgtac aaattcgaaa tcatctaaag aatacggcaa ctagtttagg aagcacgaac     2460

ttgtatggaa gcggacttgt taacgcagaa gcggcaacgc gttaa                     2505


<210>  109
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct VMA3

<400>  109
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtgctt tgccaagggt accaatgttt taatggcgga tgggtctatt      540

gaatgtattg aaaacattga ggttggtaat aaggtcatgg gtaaagatgg cagacctcgt      600

gaggtaatta aattgcccag aggaagagaa actatgtaca gcgtcgtgca gaaaagtcag      660

cacagagccc acaaaagtga ctcaagtcgt gaagtgccag aattactcaa gtttacgtgt      720

aatgcgaccc atgagttggt tgttagaaca cctcgtagtg tccgccgttt gtctcgtacc      780

attaagggtg tcgaatattt tgaagttatt acttttgaga tgggccaaaa gaaagccccc      840

gacggtagaa ttgttgagct tgtcaaggaa gtttcaaaga gctacccaat atctgagggg      900

cctgagagag ccaacgaatt agtagaatcc tatagaaagg cttcaaataa agcttatttt      960

gagtggacta ttgaggccag agatctttct ctgttgggtt cccatgttcg taaagctacc     1020

taccagactt acgctccaat tctttatgag aatgaccact ttttcgacta catgcaaaaa     1080

agtaagtttc atctcaccat tgaaggtcca aaagtacttg cttatttact tggtttatgg     1140

attggtgatg gattgtctga cagggcaact ttttcggttg attccagaga tacttctttg     1200

atggaacgtg ttactgaata tgctgaaaag ttgaatttgt gcgccgagta taaggacaga     1260

aaagaaccac aagttgccaa aactgttaat ttgtactcta aagttgtcag aggtaatggt     1320

attcgcaata atcttaatac tgagaatcca ttatgggacg ctattgttgg cttaggattc     1380

ttgaaggacg gtgtcaaaaa tattccttct ttcttgtcta cggacaatat cggtactcgt     1440

gaaacatttc ttgctggtct aattgattct gatggctatg ttactgatga gcatggtatt     1500

aaagcaacaa taaagacaat tcatacttct gtcagagatg gtttggtttc ccttgctcgt     1560

tctttaggct tagtagtctc ggttaacgca gaacctgcta aggttgacat gaatggcacc     1620

aaacataaaa ttagttatgc tatttatatg tctggtggag atgttttgct taacgttctt     1680

tcgaagtgtg ccggctctaa aaaattcagg cctgctcccg ccgctgcttt tgcacgtgag     1740

tgccgcggat tttatttcga gttacaagaa ttgaaggaag acgattatta tgggattact     1800

ttatctgatg attctgatca tcagtttttg cttgccaacc aggttgtcgt ccataattcg     1860

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat     1920

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg     1980

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat     2040

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa     2100

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt     2160

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat     2220

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc     2280

ggggtaaacg tgcagagcac atacccaggt tcaacatatg ccagcttaaa cggtacatcg     2340

atggctactc ctcatgttgc aggtgcggcc gcccttgtta aacaaaagaa cccatcttgg     2400

tctaatgtac aaattcgaaa tcatctaaag aatacggcaa ctagtttagg aagcacgaac     2460

ttgtatggaa gcggacttgt taacgcagaa gcggcaacgc gttaa                     2505


<210>  110
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic constuct VMA4

<400>  110
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttgct ttgccaaggg taccaatgtt      780

ttaatggcgg atgggtctat tgaatgtatt gaaaacattg aggttggtaa taaggtcatg      840

ggtaaagatg gcagacctcg tgaggtaatt aaattgccca gaggaagaga aactatgtac      900

agcgtcgtgc agaaaagtca gcacagagcc cacaaaagtg actcaagtcg tgaagtgcca      960

gaattactca agtttacgtg taatgcgacc catgagttgg ttgttagaac acctcgtagt     1020

gtccgccgtt tgtctcgtac cattaagggt gtcgaatatt ttgaagttat tacttttgag     1080

atgggccaaa agaaagcccc cgacggtaga attgttgagc ttgtcaagga agtttcaaag     1140

agctacccaa tatctgaggg gcctgagaga gccaacgaat tagtagaatc ctatagaaag     1200

gcttcaaata aagcttattt tgagtggact attgaggcca gagatctttc tctgttgggt     1260

tcccatgttc gtaaagctac ctaccagact tacgctccaa ttctttatga gaatgaccac     1320

tttttcgact acatgcaaaa aagtaagttt catctcacca ttgaaggtcc aaaagtactt     1380

gcttatttac ttggtttatg gattggtgat ggattgtctg acagggcaac tttttcggtt     1440

gattccagag atacttcttt gatggaacgt gttactgaat atgctgaaaa gttgaatttg     1500

tgcgccgagt ataaggacag aaaagaacca caagttgcca aaactgttaa tttgtactct     1560

aaagttgtca gaggtaatgg tattcgcaat aatcttaata ctgagaatcc attatgggac     1620

gctattgttg gcttaggatt cttgaaggac ggtgtcaaaa atattccttc tttcttgtct     1680

acggacaata tcggtactcg tgaaacattt cttgctggtc taattgattc tgatggctat     1740

gttactgatg agcatggtat taaagcaaca ataaagacaa ttcatacttc tgtcagagat     1800

ggtttggttt cccttgctcg ttctttaggc ttagtagtct cggttaacgc agaacctgct     1860

aaggttgaca tgaatggcac caaacataaa attagttatg ctatttatat gtctggtgga     1920

gatgttttgc ttaacgttct ttcgaagtgt gccggctcta aaaaattcag gcctgctccc     1980

gccgctgctt ttgcacgtga gtgccgcgga ttttatttcg agttacaaga attgaaggaa     2040

gacgattatt atgggattac tttatctgat gattctgatc atcagttttt gcttgccaac     2100

caggttgtcg tccataattc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt     2160

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat     2220

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc     2280

ggggtaaacg tgcagagcac atacccaggt tcaacatatg ccagcttaaa cggtacatcg     2340

atggctactc ctcatgttgc aggtgcggcc gcccttgtta aacaaaagaa cccatcttgg     2400

tctaatgtac aaattcgaaa tcatctaaag aatacggcaa ctagtttagg aagcacgaac     2460

ttgtatggaa gcggacttgt taacgcagaa gcggcaacgc gttaa                     2505


<210>  111
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct VMA5

<400>  111
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctgcttt gccaagggta ccaatgtttt aatggcggat      840

gggtctattg aatgtattga aaacattgag gttggtaata aggtcatggg taaagatggc      900

agacctcgtg aggtaattaa attgcccaga ggaagagaaa ctatgtacag cgtcgtgcag      960

aaaagtcagc acagagccca caaaagtgac tcaagtcgtg aagtgccaga attactcaag     1020

tttacgtgta atgcgaccca tgagttggtt gttagaacac ctcgtagtgt ccgccgtttg     1080

tctcgtacca ttaagggtgt cgaatatttt gaagttatta cttttgagat gggccaaaag     1140

aaagcccccg acggtagaat tgttgagctt gtcaaggaag tttcaaagag ctacccaata     1200

tctgaggggc ctgagagagc caacgaatta gtagaatcct atagaaaggc ttcaaataaa     1260

gcttattttg agtggactat tgaggccaga gatctttctc tgttgggttc ccatgttcgt     1320

aaagctacct accagactta cgctccaatt ctttatgaga atgaccactt tttcgactac     1380

atgcaaaaaa gtaagtttca tctcaccatt gaaggtccaa aagtacttgc ttatttactt     1440

ggtttatgga ttggtgatgg attgtctgac agggcaactt tttcggttga ttccagagat     1500

acttctttga tggaacgtgt tactgaatat gctgaaaagt tgaatttgtg cgccgagtat     1560

aaggacagaa aagaaccaca agttgccaaa actgttaatt tgtactctaa agttgtcaga     1620

ggtaatggta ttcgcaataa tcttaatact gagaatccat tatgggacgc tattgttggc     1680

ttaggattct tgaaggacgg tgtcaaaaat attccttctt tcttgtctac ggacaatatc     1740

ggtactcgtg aaacatttct tgctggtcta attgattctg atggctatgt tactgatgag     1800

catggtatta aagcaacaat aaagacaatt catacttctg tcagagatgg tttggtttcc     1860

cttgctcgtt ctttaggctt agtagtctcg gttaacgcag aacctgctaa ggttgacatg     1920

aatggcacca aacataaaat tagttatgct atttatatgt ctggtggaga tgttttgctt     1980

aacgttcttt cgaagtgtgc cggctctaaa aaattcaggc ctgctcccgc cgctgctttt     2040

gcacgtgagt gccgcggatt ttatttcgag ttacaagaat tgaaggaaga cgattattat     2100

gggattactt tatctgatga ttctgatcat cagtttttgc ttgccaacca ggttgtcgtc     2160

cataattcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat     2220

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc     2280

ggggtaaacg tgcagagcac atacccaggt tcaacatatg ccagcttaaa cggtacatcg     2340

atggctactc ctcatgttgc aggtgcggcc gcccttgtta aacaaaagaa cccatcttgg     2400

tctaatgtac aaattcgaaa tcatctaaag aatacggcaa ctagtttagg aagcacgaac     2460

ttgtatggaa gcggacttgt taacgcagaa gcggcaacgc gttaa                     2505


<210>  112
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct VMA6

<400>  112
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggttc aacatatgcc      960

agcttaaacg gtacatcgat ggctactcct catgttgcag gtgcggccgc ccttgttaaa     1020

caaaagaacc catcttggtg ctttgccaag ggtaccaatg ttttaatggc ggatgggtct     1080

attgaatgta ttgaaaacat tgaggttggt aataaggtca tgggtaaaga tggcagacct     1140

cgtgaggtaa ttaaattgcc cagaggaaga gaaactatgt acagcgtcgt gcagaaaagt     1200

cagcacagag cccacaaaag tgactcaagt cgtgaagtgc cagaattact caagtttacg     1260

tgtaatgcga cccatgagtt ggttgttaga acacctcgta gtgtccgccg tttgtctcgt     1320

accattaagg gtgtcgaata ttttgaagtt attacttttg agatgggcca aaagaaagcc     1380

cccgacggta gaattgttga gcttgtcaag gaagtttcaa agagctaccc aatatctgag     1440

gggcctgaga gagccaacga attagtagaa tcctatagaa aggcttcaaa taaagcttat     1500

tttgagtgga ctattgaggc cagagatctt tctctgttgg gttcccatgt tcgtaaagct     1560

acctaccaga cttacgctcc aattctttat gagaatgacc actttttcga ctacatgcaa     1620

aaaagtaagt ttcatctcac cattgaaggt ccaaaagtac ttgcttattt acttggttta     1680

tggattggtg atggattgtc tgacagggca actttttcgg ttgattccag agatacttct     1740

ttgatggaac gtgttactga atatgctgaa aagttgaatt tgtgcgccga gtataaggac     1800

agaaaagaac cacaagttgc caaaactgtt aatttgtact ctaaagttgt cagaggtaat     1860

ggtattcgca ataatcttaa tactgagaat ccattatggg acgctattgt tggcttagga     1920

ttcttgaagg acggtgtcaa aaatattcct tctttcttgt ctacggacaa tatcggtact     1980

cgtgaaacat ttcttgctgg tctaattgat tctgatggct atgttactga tgagcatggt     2040

attaaagcaa caataaagac aattcatact tctgtcagag atggtttggt ttcccttgct     2100

cgttctttag gcttagtagt ctcggttaac gcagaacctg ctaaggttga catgaatggc     2160

accaaacata aaattagtta tgctatttat atgtctggtg gagatgtttt gcttaacgtt     2220

ctttcgaagt gtgccggctc taaaaaattc aggcctgctc ccgccgctgc ttttgcacgt     2280

gagtgccgcg gattttattt cgagttacaa gaattgaagg aagacgatta ttatgggatt     2340

actttatctg atgattctga tcatcagttt ttgcttgcca accaggttgt cgtccataat     2400

tctaatgtac aaattcgaaa tcatctaaag aatacggcaa ctagtttagg aagcacgaac     2460

ttgtatggaa gcggacttgt taacgcagaa gcggcaacgc gttaa                     2505


<210>  113
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tth1

<400>  113
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat gcctggccga gggctcgctc      360

gtcttggacg cggctaccgg gcagagggtc cctatcgaaa aggtgcgtcc ggggatggaa      420

gttttctcct tgggacctga ttacagactg tatcgggtgc ccgttttgga ggtccttgag      480

agcggggtta gggaagttgt gcgcctcaga actcggtcag ggagaacgct ggtgttgaca      540

ccagatcacc cgcttttgac ccccgaaggt tggaaacctc tttgtgacct cccgcttgga      600

actccaattg cagtccccgc agaactgcct gtggcgggcc acttggcccc acctgaagaa      660

cgtgttacgc tcctggctct tctgttgggg gatgggaaca caaagctgtc gggtcggaga      720

ggtacacgtc ctaatgcctt cttctacagc aaagaccccg aattgctcgc ggcttatcgc      780

cggtgtgcag aagccttggg tgcaaaggtg aaagcatacg tccacccgac tacgggggtg      840

gttacactcg caaccctcgc tccacgtcct ggagctcaag atcctgtcaa acgcctcgtt      900

gtcgaggcgg gaatggttgc taaagccgaa gagaagaggg tcccggagga ggtgtttcgt      960

taccggcgtg aggcgttggc ccttttcttg ggccgtttgt tctcgacaga cggctctgtt     1020

gaaaagaaga ggatctctta ttcaagtgcc agtttgggac tggcccagga tgtcgcacat     1080

ctcttgctgc gccttggaat tacatctcaa ctccgttcga gagggccacg ggctcacgag     1140

gttcttatat cgggccgcga ggatattttg cggtttgctg aacttatcgg accctacctc     1200

ttgggggcca agagggagag acttgcagcg ctggaagctg aggcccgcag gcgtttgcct     1260

ggacagggat ggcacttgcg gcttgttctt cctgccgtgg cgtacagagt gagcgaggct     1320

aaaaggcgct cgggattttc gtggagtgaa gccggtcggc gcgtcgcagt tgcgggatcg     1380

tgtttgtcat ctggactcaa cctcaaattg cccagacgct acctttctcg gcaccggttg     1440

tcgctgctcg gtgaggcttt tgccgaccct gggctggaag cgctcgcgga aggccaagtg     1500

ctctgggacc ctattgttgc tgtcgaaccg gccggtaagg cgagaacatt cgacttgcgc     1560

gttccaccct ttgcaaactt cgtgagcgag gacctggtgg tgcataactc ggtaccatgg     1620

ggaattagcc gtgtgcaagc cccagctgcc cataaccgtg gattgacagg ttctggtgta     1680

aaagttgctg tcctcgatac agggatatcc actcatccag atctaaatat tcgtggtggc     1740

gcaagctttg taccagggga accgtcgact caagatggga atgggcatgg cacgcatgtg     1800

gccgggacga tcgctgcttt aaacaattcg attggcgttc ttggcgtagc gccgagcgct     1860

gagctatacg ctgttaaagt cctaggggcg agcggttcag gttcggtcag ctcgattgcc     1920

caaggattgg aatgggcagg gaacaatggc atgcacgttg ctaatttgag tttaggaagc     1980

ccttcgccaa gtgccacact tgagcaagct gttaatagcg cgacttctag aggcgttctt     2040

gttgtagcgg catctgggaa ctcaggtgca ggctcaatca gctatccggc gcgctatgcg     2100

aacgcaatgg cagtcggagc tactgatcaa aacaacaacc gcgctagctt ttcacagtat     2160

ggcgcaggcc ttgacattgt cgcacccggg gtaaacgtgc agagcacata cccaggttca     2220

acatatgcca gcttaaacgg tacatcgatg gctactcctc atgttgcagg tgcggccgcc     2280

cttgttaaac aaaagaaccc atcttggtct aatgtacaaa ttcgaaatca tctaaagaat     2340

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg     2400

gcaacgcgtt aa                                                         2412


<210>  114
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tth2

<400>  114
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc ctgcctggcc gagggctcgc tcgtcttgga cgcggctacc      480

gggcagaggg tccctatcga aaaggtgcgt ccggggatgg aagttttctc cttgggacct      540

gattacagac tgtatcgggt gcccgttttg gaggtccttg agagcggggt tagggaagtt      600

gtgcgcctca gaactcggtc agggagaacg ctggtgttga caccagatca cccgcttttg      660

acccccgaag gttggaaacc tctttgtgac ctcccgcttg gaactccaat tgcagtcccc      720

gcagaactgc ctgtggcggg ccacttggcc ccacctgaag aacgtgttac gctcctggct      780

cttctgttgg gggatgggaa cacaaagctg tcgggtcgga gaggtacacg tcctaatgcc      840

ttcttctaca gcaaagaccc cgaattgctc gcggcttatc gccggtgtgc agaagccttg      900

ggtgcaaagg tgaaagcata cgtccacccg actacggggg tggttacact cgcaaccctc      960

gctccacgtc ctggagctca agatcctgtc aaacgcctcg ttgtcgaggc gggaatggtt     1020

gctaaagccg aagagaagag ggtcccggag gaggtgtttc gttaccggcg tgaggcgttg     1080

gcccttttct tgggccgttt gttctcgaca gacggctctg ttgaaaagaa gaggatctct     1140

tattcaagtg ccagtttggg actggcccag gatgtcgcac atctcttgct gcgccttgga     1200

attacatctc aactccgttc gagagggcca cgggctcacg aggttcttat atcgggccgc     1260

gaggatattt tgcggtttgc tgaacttatc ggaccctacc tcttgggggc caagagggag     1320

agacttgcag cgctggaagc tgaggcccgc aggcgtttgc ctggacaggg atggcacttg     1380

cggcttgttc ttcctgccgt ggcgtacaga gtgagcgagg ctaaaaggcg ctcgggattt     1440

tcgtggagtg aagccggtcg gcgcgtcgca gttgcgggat cgtgtttgtc atctggactc     1500

aacctcaaat tgcccagacg ctacctttct cggcaccggt tgtcgctgct cggtgaggct     1560

tttgccgacc ctgggctgga agcgctcgcg gaaggccaag tgctctggga ccctattgtt     1620

gctgtcgaac cggccggtaa ggcgagaaca ttcgacttgc gcgttccacc ctttgcaaac     1680

ttcgtgagcg aggacctggt ggtgcataac actcatccag atctaaatat tcgtggtggc     1740

gcaagctttg taccagggga accgtcgact caagatggga atgggcatgg cacgcatgtg     1800

gccgggacga tcgctgcttt aaacaattcg attggcgttc ttggcgtagc gccgagcgct     1860

gagctatacg ctgttaaagt cctaggggcg agcggttcag gttcggtcag ctcgattgcc     1920

caaggattgg aatgggcagg gaacaatggc atgcacgttg ctaatttgag tttaggaagc     1980

ccttcgccaa gtgccacact tgagcaagct gttaatagcg cgacttctag aggcgttctt     2040

gttgtagcgg catctgggaa ctcaggtgca ggctcaatca gctatccggc gcgctatgcg     2100

aacgcaatgg cagtcggagc tactgatcaa aacaacaacc gcgctagctt ttcacagtat     2160

ggcgcaggcc ttgacattgt cgcacccggg gtaaacgtgc agagcacata cccaggttca     2220

acatatgcca gcttaaacgg tacatcgatg gctactcctc atgttgcagg tgcggccgcc     2280

cttgttaaac aaaagaaccc atcttggtct aatgtacaaa ttcgaaatca tctaaagaat     2340

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg     2400

gcaacgcgtt aa                                                         2412


<210>  115
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tth3

<400>  115
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtgcct ggccgagggc tcgctcgtct tggacgcggc taccgggcag      540

agggtcccta tcgaaaaggt gcgtccgggg atggaagttt tctccttggg acctgattac      600

agactgtatc gggtgcccgt tttggaggtc cttgagagcg gggttaggga agttgtgcgc      660

ctcagaactc ggtcagggag aacgctggtg ttgacaccag atcacccgct tttgaccccc      720

gaaggttgga aacctctttg tgacctcccg cttggaactc caattgcagt ccccgcagaa      780

ctgcctgtgg cgggccactt ggccccacct gaagaacgtg ttacgctcct ggctcttctg      840

ttgggggatg ggaacacaaa gctgtcgggt cggagaggta cacgtcctaa tgccttcttc      900

tacagcaaag accccgaatt gctcgcggct tatcgccggt gtgcagaagc cttgggtgca      960

aaggtgaaag catacgtcca cccgactacg ggggtggtta cactcgcaac cctcgctcca     1020

cgtcctggag ctcaagatcc tgtcaaacgc ctcgttgtcg aggcgggaat ggttgctaaa     1080

gccgaagaga agagggtccc ggaggaggtg tttcgttacc ggcgtgaggc gttggccctt     1140

ttcttgggcc gtttgttctc gacagacggc tctgttgaaa agaagaggat ctcttattca     1200

agtgccagtt tgggactggc ccaggatgtc gcacatctct tgctgcgcct tggaattaca     1260

tctcaactcc gttcgagagg gccacgggct cacgaggttc ttatatcggg ccgcgaggat     1320

attttgcggt ttgctgaact tatcggaccc tacctcttgg gggccaagag ggagagactt     1380

gcagcgctgg aagctgaggc ccgcaggcgt ttgcctggac agggatggca cttgcggctt     1440

gttcttcctg ccgtggcgta cagagtgagc gaggctaaaa ggcgctcggg attttcgtgg     1500

agtgaagccg gtcggcgcgt cgcagttgcg ggatcgtgtt tgtcatctgg actcaacctc     1560

aaattgccca gacgctacct ttctcggcac cggttgtcgc tgctcggtga ggcttttgcc     1620

gaccctgggc tggaagcgct cgcggaaggc caagtgctct gggaccctat tgttgctgtc     1680

gaaccggccg gtaaggcgag aacattcgac ttgcgcgttc caccctttgc aaacttcgtg     1740

agcgaggacc tggtggtgca taactcgact caagatggga atgggcatgg cacgcatgtg     1800

gccgggacga tcgctgcttt aaacaattcg attggcgttc ttggcgtagc gccgagcgct     1860

gagctatacg ctgttaaagt cctaggggcg agcggttcag gttcggtcag ctcgattgcc     1920

caaggattgg aatgggcagg gaacaatggc atgcacgttg ctaatttgag tttaggaagc     1980

ccttcgccaa gtgccacact tgagcaagct gttaatagcg cgacttctag aggcgttctt     2040

gttgtagcgg catctgggaa ctcaggtgca ggctcaatca gctatccggc gcgctatgcg     2100

aacgcaatgg cagtcggagc tactgatcaa aacaacaacc gcgctagctt ttcacagtat     2160

ggcgcaggcc ttgacattgt cgcacccggg gtaaacgtgc agagcacata cccaggttca     2220

acatatgcca gcttaaacgg tacatcgatg gctactcctc atgttgcagg tgcggccgcc     2280

cttgttaaac aaaagaaccc atcttggtct aatgtacaaa ttcgaaatca tctaaagaat     2340

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg     2400

gcaacgcgtt aa                                                         2412


<210>  116
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tth4

<400>  116
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttgcc tggccgaggg ctcgctcgtc      780

ttggacgcgg ctaccgggca gagggtccct atcgaaaagg tgcgtccggg gatggaagtt      840

ttctccttgg gacctgatta cagactgtat cgggtgcccg ttttggaggt ccttgagagc      900

ggggttaggg aagttgtgcg cctcagaact cggtcaggga gaacgctggt gttgacacca      960

gatcacccgc ttttgacccc cgaaggttgg aaacctcttt gtgacctccc gcttggaact     1020

ccaattgcag tccccgcaga actgcctgtg gcgggccact tggccccacc tgaagaacgt     1080

gttacgctcc tggctcttct gttgggggat gggaacacaa agctgtcggg tcggagaggt     1140

acacgtccta atgccttctt ctacagcaaa gaccccgaat tgctcgcggc ttatcgccgg     1200

tgtgcagaag ccttgggtgc aaaggtgaaa gcatacgtcc acccgactac gggggtggtt     1260

acactcgcaa ccctcgctcc acgtcctgga gctcaagatc ctgtcaaacg cctcgttgtc     1320

gaggcgggaa tggttgctaa agccgaagag aagagggtcc cggaggaggt gtttcgttac     1380

cggcgtgagg cgttggccct tttcttgggc cgtttgttct cgacagacgg ctctgttgaa     1440

aagaagagga tctcttattc aagtgccagt ttgggactgg cccaggatgt cgcacatctc     1500

ttgctgcgcc ttggaattac atctcaactc cgttcgagag ggccacgggc tcacgaggtt     1560

cttatatcgg gccgcgagga tattttgcgg tttgctgaac ttatcggacc ctacctcttg     1620

ggggccaaga gggagagact tgcagcgctg gaagctgagg cccgcaggcg tttgcctgga     1680

cagggatggc acttgcggct tgttcttcct gccgtggcgt acagagtgag cgaggctaaa     1740

aggcgctcgg gattttcgtg gagtgaagcc ggtcggcgcg tcgcagttgc gggatcgtgt     1800

ttgtcatctg gactcaacct caaattgccc agacgctacc tttctcggca ccggttgtcg     1860

ctgctcggtg aggcttttgc cgaccctggg ctggaagcgc tcgcggaagg ccaagtgctc     1920

tgggacccta ttgttgctgt cgaaccggcc ggtaaggcga gaacattcga cttgcgcgtt     1980

ccaccctttg caaacttcgt gagcgaggac ctggtggtgc ataactctag aggcgttctt     2040

gttgtagcgg catctgggaa ctcaggtgca ggctcaatca gctatccggc gcgctatgcg     2100

aacgcaatgg cagtcggagc tactgatcaa aacaacaacc gcgctagctt ttcacagtat     2160

ggcgcaggcc ttgacattgt cgcacccggg gtaaacgtgc agagcacata cccaggttca     2220

acatatgcca gcttaaacgg tacatcgatg gctactcctc atgttgcagg tgcggccgcc     2280

cttgttaaac aaaagaaccc atcttggtct aatgtacaaa ttcgaaatca tctaaagaat     2340

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg     2400

gcaacgcgtt aa                                                         2412


<210>  117
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tth5

<400>  117
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctgcctg gccgagggct cgctcgtctt ggacgcggct      840

accgggcaga gggtccctat cgaaaaggtg cgtccgggga tggaagtttt ctccttggga      900

cctgattaca gactgtatcg ggtgcccgtt ttggaggtcc ttgagagcgg ggttagggaa      960

gttgtgcgcc tcagaactcg gtcagggaga acgctggtgt tgacaccaga tcacccgctt     1020

ttgacccccg aaggttggaa acctctttgt gacctcccgc ttggaactcc aattgcagtc     1080

cccgcagaac tgcctgtggc gggccacttg gccccacctg aagaacgtgt tacgctcctg     1140

gctcttctgt tgggggatgg gaacacaaag ctgtcgggtc ggagaggtac acgtcctaat     1200

gccttcttct acagcaaaga ccccgaattg ctcgcggctt atcgccggtg tgcagaagcc     1260

ttgggtgcaa aggtgaaagc atacgtccac ccgactacgg gggtggttac actcgcaacc     1320

ctcgctccac gtcctggagc tcaagatcct gtcaaacgcc tcgttgtcga ggcgggaatg     1380

gttgctaaag ccgaagagaa gagggtcccg gaggaggtgt ttcgttaccg gcgtgaggcg     1440

ttggcccttt tcttgggccg tttgttctcg acagacggct ctgttgaaaa gaagaggatc     1500

tcttattcaa gtgccagttt gggactggcc caggatgtcg cacatctctt gctgcgcctt     1560

ggaattacat ctcaactccg ttcgagaggg ccacgggctc acgaggttct tatatcgggc     1620

cgcgaggata ttttgcggtt tgctgaactt atcggaccct acctcttggg ggccaagagg     1680

gagagacttg cagcgctgga agctgaggcc cgcaggcgtt tgcctggaca gggatggcac     1740

ttgcggcttg ttcttcctgc cgtggcgtac agagtgagcg aggctaaaag gcgctcggga     1800

ttttcgtgga gtgaagccgg tcggcgcgtc gcagttgcgg gatcgtgttt gtcatctgga     1860

ctcaacctca aattgcccag acgctacctt tctcggcacc ggttgtcgct gctcggtgag     1920

gcttttgccg accctgggct ggaagcgctc gcggaaggcc aagtgctctg ggaccctatt     1980

gttgctgtcg aaccggccgg taaggcgaga acattcgact tgcgcgttcc accctttgca     2040

aacttcgtga gcgaggacct ggtggtgcat aactcaatca gctatccggc gcgctatgcg     2100

aacgcaatgg cagtcggagc tactgatcaa aacaacaacc gcgctagctt ttcacagtat     2160

ggcgcaggcc ttgacattgt cgcacccggg gtaaacgtgc agagcacata cccaggttca     2220

acatatgcca gcttaaacgg tacatcgatg gctactcctc atgttgcagg tgcggccgcc     2280

cttgttaaac aaaagaaccc atcttggtct aatgtacaaa ttcgaaatca tctaaagaat     2340

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg     2400

gcaacgcgtt aa                                                         2412


<210>  118
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tth6

<400>  118
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggttc aacatatgcc      960

agcttaaacg gtacatcgat ggctactcct catgttgcag gtgcggccgc ccttgttaaa     1020

caaaagaacc catcttggtg cctggccgag ggctcgctcg tcttggacgc ggctaccggg     1080

cagagggtcc ctatcgaaaa ggtgcgtccg gggatggaag ttttctcctt gggacctgat     1140

tacagactgt atcgggtgcc cgttttggag gtccttgaga gcggggttag ggaagttgtg     1200

cgcctcagaa ctcggtcagg gagaacgctg gtgttgacac cagatcaccc gcttttgacc     1260

cccgaaggtt ggaaacctct ttgtgacctc ccgcttggaa ctccaattgc agtccccgca     1320

gaactgcctg tggcgggcca cttggcccca cctgaagaac gtgttacgct cctggctctt     1380

ctgttggggg atgggaacac aaagctgtcg ggtcggagag gtacacgtcc taatgccttc     1440

ttctacagca aagaccccga attgctcgcg gcttatcgcc ggtgtgcaga agccttgggt     1500

gcaaaggtga aagcatacgt ccacccgact acgggggtgg ttacactcgc aaccctcgct     1560

ccacgtcctg gagctcaaga tcctgtcaaa cgcctcgttg tcgaggcggg aatggttgct     1620

aaagccgaag agaagagggt cccggaggag gtgtttcgtt accggcgtga ggcgttggcc     1680

cttttcttgg gccgtttgtt ctcgacagac ggctctgttg aaaagaagag gatctcttat     1740

tcaagtgcca gtttgggact ggcccaggat gtcgcacatc tcttgctgcg ccttggaatt     1800

acatctcaac tccgttcgag agggccacgg gctcacgagg ttcttatatc gggccgcgag     1860

gatattttgc ggtttgctga acttatcgga ccctacctct tgggggccaa gagggagaga     1920

cttgcagcgc tggaagctga ggcccgcagg cgtttgcctg gacagggatg gcacttgcgg     1980

cttgttcttc ctgccgtggc gtacagagtg agcgaggcta aaaggcgctc gggattttcg     2040

tggagtgaag ccggtcggcg cgtcgcagtt gcgggatcgt gtttgtcatc tggactcaac     2100

ctcaaattgc ccagacgcta cctttctcgg caccggttgt cgctgctcgg tgaggctttt     2160

gccgaccctg ggctggaagc gctcgcggaa ggccaagtgc tctgggaccc tattgttgct     2220

gtcgaaccgg ccggtaaggc gagaacattc gacttgcgcg ttccaccctt tgcaaacttc     2280

gtgagcgagg acctggtggt gcataactct aatgtacaaa ttcgaaatca tctaaagaat     2340

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg     2400

gcaacgcgtt aa                                                         2412


<210>  119
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct mTth:EU59 intein

<400>  119

Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln Arg 
1               5                   10                  15      


Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu Gly 
            20                  25                  30          


Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu Ser 
        35                  40                  45              


Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu 
    50                  55                  60                  


Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro 
65                  70                  75                  80  


Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Ala Gln Thr Cys 
                85                  90                  95      


Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe Phe Tyr Ser Phe 
            100                 105                 110         


Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu Leu Glu Gly Gly 
        115                 120                 125             


Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp Val Gly Gly Lys 
    130                 135                 140                 


Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser Gly Ser Phe 
145                 150                 155                 160 


Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp Thr Thr Asn 
                165                 170                 175     


Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser Trp Arg Pro 
            180                 185                 190         


Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn Ser Asp Gly Gly 
        195                 200                 205             


Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro Ser Ile Ile 
    210                 215                 220                 


Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln Ser Lys Arg 
225                 230                 235                 240 


Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp Ala Trp Ala Ser 
                245                 250                 255     


Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile Met Ala Thr Glu 
            260                 265                 270         


Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val Ser Arg Asp Val 
        275                 280                 285             


Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro Ala 
    290                 295                 300                 


Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn Phe 
305                 310                 315                 320 


Val Ser Glu Asp Leu Val Val His Asn 
                325                 


<210>  120
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S46

<400>  120

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly 
            20                  25                  30          


Gln Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser 
        35                  40                  45              


Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu 
    50                  55                  60                  


Glu Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg 
65                  70                  75                  80  


Thr Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp 
                85                  90                  95      


Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Ala Gln 
            100                 105                 110         


Thr Cys Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe Phe Tyr 
        115                 120                 125             


Ser Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu Leu Glu 
    130                 135                 140                 


Gly Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp Val Gly 
145                 150                 155                 160 


Gly Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser Gly 
                165                 170                 175     


Ser Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp Thr 
            180                 185                 190         


Thr Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser Trp 
        195                 200                 205             


Arg Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn Ser Asp 
    210                 215                 220                 


Gly Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro Ser 
225                 230                 235                 240 


Ile Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln Ser 
                245                 250                 255     


Lys Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp Ala Trp 
            260                 265                 270         


Ala Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile Met Ala 
        275                 280                 285             


Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val Ser Arg 
    290                 295                 300                 


Asp Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu 
305                 310                 315                 320 


Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala 
                325                 330                 335     


Asn Phe Val Ser Glu Asp Leu Val Val His Asn Ser Glu Phe Val Glu 
            340                 345                 350         


Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu Glu Glu 
        355                 360                 365             


Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val Leu Ser 
    370                 375                 380                 


Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp Pro Ala 
385                 390                 395                 400 


Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala Gln Ser 
                405                 410                 415     


Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His Asn Arg 
            420                 425                 430         


Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        435                 440                 445             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    450                 455                 460                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
465                 470                 475                 480 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                485                 490                 495     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  121
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S62

<400>  121

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly 
        35                  40                  45              


Gln Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser 
    50                  55                  60                  


Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu 
65                  70                  75                  80  


Glu Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg 
                85                  90                  95      


Thr Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp 
            100                 105                 110         


Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Ala Gln 
        115                 120                 125             


Thr Cys Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe Phe Tyr 
    130                 135                 140                 


Ser Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu Leu Glu 
145                 150                 155                 160 


Gly Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp Val Gly 
                165                 170                 175     


Gly Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser Gly 
            180                 185                 190         


Ser Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp Thr 
        195                 200                 205             


Thr Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser Trp 
    210                 215                 220                 


Arg Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn Ser Asp 
225                 230                 235                 240 


Gly Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro Ser 
                245                 250                 255     


Ile Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln Ser 
            260                 265                 270         


Lys Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp Ala Trp 
        275                 280                 285             


Ala Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile Met Ala 
    290                 295                 300                 


Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val Ser Arg 
305                 310                 315                 320 


Asp Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu 
                325                 330                 335     


Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala 
            340                 345                 350         


Asn Phe Val Ser Glu Asp Leu Val Val His Asn Ser Glu Glu Glu Glu 
        355                 360                 365             


Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val Leu Ser 
    370                 375                 380                 


Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp Pro Ala 
385                 390                 395                 400 


Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala Gln Ser 
                405                 410                 415     


Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His Asn Arg 
            420                 425                 430         


Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        435                 440                 445             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    450                 455                 460                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
465                 470                 475                 480 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                485                 490                 495     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  122
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T77

<400>  122

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln 
    50                  55                  60                  


Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu 
65                  70                  75                  80  


Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu 
                85                  90                  95      


Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr 
            100                 105                 110         


Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys 
        115                 120                 125             


Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Ala Gln Thr 
    130                 135                 140                 


Cys Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe Phe Tyr Ser 
145                 150                 155                 160 


Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu Leu Glu Gly 
                165                 170                 175     


Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp Val Gly Gly 
            180                 185                 190         


Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser Gly Ser 
        195                 200                 205             


Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp Thr Thr 
    210                 215                 220                 


Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser Trp Arg 
225                 230                 235                 240 


Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn Ser Asp Gly 
                245                 250                 255     


Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro Ser Ile 
            260                 265                 270         


Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln Ser Lys 
        275                 280                 285             


Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp Ala Trp Ala 
    290                 295                 300                 


Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile Met Ala Thr 
305                 310                 315                 320 


Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val Ser Arg Asp 
                325                 330                 335     


Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro 
            340                 345                 350         


Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn 
        355                 360                 365             


Phe Val Ser Glu Asp Leu Val Val His Asn Thr Ile Pro Val Leu Ser 
    370                 375                 380                 


Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp Pro Ala 
385                 390                 395                 400 


Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala Gln Ser 
                405                 410                 415     


Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His Asn Arg 
            420                 425                 430         


Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        435                 440                 445             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    450                 455                 460                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
465                 470                 475                 480 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                485                 490                 495     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  123
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S86

<400>  123

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Cys Leu Ala Glu Gly Ser 
    50                  55                  60                  


Leu Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys Val 
65                  70                  75                  80  


Arg Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr 
                85                  90                  95      


Arg Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val Val 
            100                 105                 110         


Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp His 
        115                 120                 125             


Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu 
    130                 135                 140                 


Gly Thr Pro Ile Ala Val Ala Gln Thr Cys Leu Thr Ser Pro Gln Thr 
145                 150                 155                 160 


Gly Phe His Asn Gly Phe Phe Tyr Ser Phe Trp Lys Asp Ser Pro Gly 
                165                 170                 175     


Thr Val Asn Phe Cys Leu Leu Glu Gly Gly Arg Tyr Thr Ser Asn Trp 
            180                 185                 190         


Ser Gly Ile Asn Asn Trp Val Gly Gly Lys Gly Trp Gln Thr Gly Ser 
        195                 200                 205             


Arg Arg Asn Ile Thr Tyr Ser Gly Ser Phe Asn Thr Pro Gly Asn Gly 
    210                 215                 220                 


Tyr Leu Ala Leu Tyr Gly Trp Thr Thr Asn Pro Leu Val Glu Tyr Tyr 
225                 230                 235                 240 


Val Val Asp Ser Trp Gly Ser Trp Arg Pro Pro Gly Ser Asp Gly Thr 
                245                 250                 255     


Phe Leu Gly Thr Val Asn Ser Asp Gly Gly Thr Tyr Asp Ile Tyr Arg 
            260                 265                 270         


Ala Gln Arg Val Asn Ala Pro Ser Ile Ile Gly Asn Ala Thr Phe Tyr 
        275                 280                 285             


Gln Tyr Trp Ser Val Arg Gln Ser Lys Arg Val Gly Gly Thr Ile Thr 
    290                 295                 300                 


Thr Gly Asn His Phe Asp Ala Trp Ala Ser Val Gly Leu Asn Leu Gly 
305                 310                 315                 320 


Thr His Asn Tyr Gln Ile Met Ala Thr Glu Gly Tyr Gln Ser Ser Gly 
                325                 330                 335     


Ser Ser Asp Ile Thr Val Ser Arg Asp Val Glu Thr Gly Glu Val Leu 
            340                 345                 350         


Trp Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe 
        355                 360                 365             


Asp Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val 
    370                 375                 380                 


Val His Asn Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp Pro Ala 
385                 390                 395                 400 


Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala Gln Ser 
                405                 410                 415     


Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His Asn Arg 
            420                 425                 430         


Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        435                 440                 445             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    450                 455                 460                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
465                 470                 475                 480 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                485                 490                 495     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  124
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S100

<400>  124

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Cys Leu Ala Glu Gly Ser Leu Val 
65                  70                  75                  80  


Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys Val Arg Pro 
                85                  90                  95      


Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val 
            100                 105                 110         


Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val Val Arg Leu 
        115                 120                 125             


Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp His Pro Leu 
    130                 135                 140                 


Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr 
145                 150                 155                 160 


Pro Ile Ala Val Ala Gln Thr Cys Leu Thr Ser Pro Gln Thr Gly Phe 
                165                 170                 175     


His Asn Gly Phe Phe Tyr Ser Phe Trp Lys Asp Ser Pro Gly Thr Val 
            180                 185                 190         


Asn Phe Cys Leu Leu Glu Gly Gly Arg Tyr Thr Ser Asn Trp Ser Gly 
        195                 200                 205             


Ile Asn Asn Trp Val Gly Gly Lys Gly Trp Gln Thr Gly Ser Arg Arg 
    210                 215                 220                 


Asn Ile Thr Tyr Ser Gly Ser Phe Asn Thr Pro Gly Asn Gly Tyr Leu 
225                 230                 235                 240 


Ala Leu Tyr Gly Trp Thr Thr Asn Pro Leu Val Glu Tyr Tyr Val Val 
                245                 250                 255     


Asp Ser Trp Gly Ser Trp Arg Pro Pro Gly Ser Asp Gly Thr Phe Leu 
            260                 265                 270         


Gly Thr Val Asn Ser Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Ala Gln 
        275                 280                 285             


Arg Val Asn Ala Pro Ser Ile Ile Gly Asn Ala Thr Phe Tyr Gln Tyr 
    290                 295                 300                 


Trp Ser Val Arg Gln Ser Lys Arg Val Gly Gly Thr Ile Thr Thr Gly 
305                 310                 315                 320 


Asn His Phe Asp Ala Trp Ala Ser Val Gly Leu Asn Leu Gly Thr His 
                325                 330                 335     


Asn Tyr Gln Ile Met Ala Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser 
            340                 345                 350         


Asp Ile Thr Val Ser Arg Asp Val Glu Thr Gly Glu Val Leu Trp Asp 
        355                 360                 365             


Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu 
    370                 375                 380                 


Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val Val His 
385                 390                 395                 400 


Asn Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala Gln Ser 
                405                 410                 415     


Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His Asn Arg 
            420                 425                 430         


Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        435                 440                 445             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    450                 455                 460                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
465                 470                 475                 480 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                485                 490                 495     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  125
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T109

<400>  125

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln 
                85                  90                  95      


Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu 
            100                 105                 110         


Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr 
    130                 135                 140                 


Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys 
145                 150                 155                 160 


Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Ala Gln Thr 
                165                 170                 175     


Cys Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe Phe Tyr Ser 
            180                 185                 190         


Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu Leu Glu Gly 
        195                 200                 205             


Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp Val Gly Gly 
    210                 215                 220                 


Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser Gly Ser 
225                 230                 235                 240 


Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp Thr Thr 
                245                 250                 255     


Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser Trp Arg 
            260                 265                 270         


Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn Ser Asp Gly 
        275                 280                 285             


Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro Ser Ile 
    290                 295                 300                 


Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln Ser Lys 
305                 310                 315                 320 


Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp Ala Trp Ala 
                325                 330                 335     


Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile Met Ala Thr 
            340                 345                 350         


Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val Ser Arg Asp 
        355                 360                 365             


Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro 
    370                 375                 380                 


Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn 
385                 390                 395                 400 


Phe Val Ser Glu Asp Leu Val Val His Asn Thr Thr Met Ala Gln Ser 
                405                 410                 415     


Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His Asn Arg 
            420                 425                 430         


Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        435                 440                 445             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    450                 455                 460                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
465                 470                 475                 480 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                485                 490                 495     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  126
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S135

<400>  126

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Glu Gly 
            100                 105                 110         


Ser Leu Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys 
        115                 120                 125             


Val Arg Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu 
    130                 135                 140                 


Tyr Arg Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val 
145                 150                 155                 160 


Val Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp 
                165                 170                 175     


His Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro 
            180                 185                 190         


Leu Gly Thr Pro Ile Ala Val Ala Gln Thr Cys Leu Thr Ser Pro Gln 
        195                 200                 205             


Thr Gly Phe His Asn Gly Phe Phe Tyr Ser Phe Trp Lys Asp Ser Pro 
    210                 215                 220                 


Gly Thr Val Asn Phe Cys Leu Leu Glu Gly Gly Arg Tyr Thr Ser Asn 
225                 230                 235                 240 


Trp Ser Gly Ile Asn Asn Trp Val Gly Gly Lys Gly Trp Gln Thr Gly 
                245                 250                 255     


Ser Arg Arg Asn Ile Thr Tyr Ser Gly Ser Phe Asn Thr Pro Gly Asn 
            260                 265                 270         


Gly Tyr Leu Ala Leu Tyr Gly Trp Thr Thr Asn Pro Leu Val Glu Tyr 
        275                 280                 285             


Tyr Val Val Asp Ser Trp Gly Ser Trp Arg Pro Pro Gly Ser Asp Gly 
    290                 295                 300                 


Thr Phe Leu Gly Thr Val Asn Ser Asp Gly Gly Thr Tyr Asp Ile Tyr 
305                 310                 315                 320 


Arg Ala Gln Arg Val Asn Ala Pro Ser Ile Ile Gly Asn Ala Thr Phe 
                325                 330                 335     


Tyr Gln Tyr Trp Ser Val Arg Gln Ser Lys Arg Val Gly Gly Thr Ile 
            340                 345                 350         


Thr Thr Gly Asn His Phe Asp Ala Trp Ala Ser Val Gly Leu Asn Leu 
        355                 360                 365             


Gly Thr His Asn Tyr Gln Ile Met Ala Thr Glu Gly Tyr Gln Ser Ser 
    370                 375                 380                 


Gly Ser Ser Asp Ile Thr Val Ser Arg Asp Val Glu Thr Gly Glu Val 
385                 390                 395                 400 


Leu Trp Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr 
                405                 410                 415     


Phe Asp Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu 
            420                 425                 430         


Val Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        435                 440                 445             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    450                 455                 460                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
465                 470                 475                 480 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                485                 490                 495     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  127
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T148

<400>  127

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Cys Leu Ala Glu Gly Ser Leu Val 
        115                 120                 125             


Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys Val Arg Pro 
    130                 135                 140                 


Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val 
145                 150                 155                 160 


Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val Val Arg Leu 
                165                 170                 175     


Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp His Pro Leu 
            180                 185                 190         


Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr 
        195                 200                 205             


Pro Ile Ala Val Ala Gln Thr Cys Leu Thr Ser Pro Gln Thr Gly Phe 
    210                 215                 220                 


His Asn Gly Phe Phe Tyr Ser Phe Trp Lys Asp Ser Pro Gly Thr Val 
225                 230                 235                 240 


Asn Phe Cys Leu Leu Glu Gly Gly Arg Tyr Thr Ser Asn Trp Ser Gly 
                245                 250                 255     


Ile Asn Asn Trp Val Gly Gly Lys Gly Trp Gln Thr Gly Ser Arg Arg 
            260                 265                 270         


Asn Ile Thr Tyr Ser Gly Ser Phe Asn Thr Pro Gly Asn Gly Tyr Leu 
        275                 280                 285             


Ala Leu Tyr Gly Trp Thr Thr Asn Pro Leu Val Glu Tyr Tyr Val Val 
    290                 295                 300                 


Asp Ser Trp Gly Ser Trp Arg Pro Pro Gly Ser Asp Gly Thr Phe Leu 
305                 310                 315                 320 


Gly Thr Val Asn Ser Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Ala Gln 
                325                 330                 335     


Arg Val Asn Ala Pro Ser Ile Ile Gly Asn Ala Thr Phe Tyr Gln Tyr 
            340                 345                 350         


Trp Ser Val Arg Gln Ser Lys Arg Val Gly Gly Thr Ile Thr Thr Gly 
        355                 360                 365             


Asn His Phe Asp Ala Trp Ala Ser Val Gly Leu Asn Leu Gly Thr His 
    370                 375                 380                 


Asn Tyr Gln Ile Met Ala Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser 
385                 390                 395                 400 


Asp Ile Thr Val Ser Arg Asp Val Glu Thr Gly Glu Val Leu Trp Asp 
                405                 410                 415     


Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu 
            420                 425                 430         


Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val Val His 
        435                 440                 445             


Asn Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    450                 455                 460                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
465                 470                 475                 480 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                485                 490                 495     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  128
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S166

<400>  128

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Cys Leu Ala Glu Gly Ser 
    130                 135                 140                 


Leu Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys Val 
145                 150                 155                 160 


Arg Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr 
                165                 170                 175     


Arg Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val Val 
            180                 185                 190         


Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp His 
        195                 200                 205             


Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu 
    210                 215                 220                 


Gly Thr Pro Ile Ala Val Ala Gln Thr Cys Leu Thr Ser Pro Gln Thr 
225                 230                 235                 240 


Gly Phe His Asn Gly Phe Phe Tyr Ser Phe Trp Lys Asp Ser Pro Gly 
                245                 250                 255     


Thr Val Asn Phe Cys Leu Leu Glu Gly Gly Arg Tyr Thr Ser Asn Trp 
            260                 265                 270         


Ser Gly Ile Asn Asn Trp Val Gly Gly Lys Gly Trp Gln Thr Gly Ser 
        275                 280                 285             


Arg Arg Asn Ile Thr Tyr Ser Gly Ser Phe Asn Thr Pro Gly Asn Gly 
    290                 295                 300                 


Tyr Leu Ala Leu Tyr Gly Trp Thr Thr Asn Pro Leu Val Glu Tyr Tyr 
305                 310                 315                 320 


Val Val Asp Ser Trp Gly Ser Trp Arg Pro Pro Gly Ser Asp Gly Thr 
                325                 330                 335     


Phe Leu Gly Thr Val Asn Ser Asp Gly Gly Thr Tyr Asp Ile Tyr Arg 
            340                 345                 350         


Ala Gln Arg Val Asn Ala Pro Ser Ile Ile Gly Asn Ala Thr Phe Tyr 
        355                 360                 365             


Gln Tyr Trp Ser Val Arg Gln Ser Lys Arg Val Gly Gly Thr Ile Thr 
    370                 375                 380                 


Thr Gly Asn His Phe Asp Ala Trp Ala Ser Val Gly Leu Asn Leu Gly 
385                 390                 395                 400 


Thr His Asn Tyr Gln Ile Met Ala Thr Glu Gly Tyr Gln Ser Ser Gly 
                405                 410                 415     


Ser Ser Asp Ile Thr Val Ser Arg Asp Val Glu Thr Gly Glu Val Leu 
            420                 425                 430         


Trp Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe 
        435                 440                 445             


Asp Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val 
    450                 455                 460                 


Val His Asn Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
465                 470                 475                 480 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                485                 490                 495     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  129
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T167

<400>  129

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Cys Leu Ala Glu Gly 
    130                 135                 140                 


Ser Leu Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys 
145                 150                 155                 160 


Val Arg Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu 
                165                 170                 175     


Tyr Arg Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val 
            180                 185                 190         


Val Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp 
        195                 200                 205             


His Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro 
    210                 215                 220                 


Leu Gly Thr Pro Ile Ala Val Ala Gln Thr Cys Leu Thr Ser Pro Gln 
225                 230                 235                 240 


Thr Gly Phe His Asn Gly Phe Phe Tyr Ser Phe Trp Lys Asp Ser Pro 
                245                 250                 255     


Gly Thr Val Asn Phe Cys Leu Leu Glu Gly Gly Arg Tyr Thr Ser Asn 
            260                 265                 270         


Trp Ser Gly Ile Asn Asn Trp Val Gly Gly Lys Gly Trp Gln Thr Gly 
        275                 280                 285             


Ser Arg Arg Asn Ile Thr Tyr Ser Gly Ser Phe Asn Thr Pro Gly Asn 
    290                 295                 300                 


Gly Tyr Leu Ala Leu Tyr Gly Trp Thr Thr Asn Pro Leu Val Glu Tyr 
305                 310                 315                 320 


Tyr Val Val Asp Ser Trp Gly Ser Trp Arg Pro Pro Gly Ser Asp Gly 
                325                 330                 335     


Thr Phe Leu Gly Thr Val Asn Ser Asp Gly Gly Thr Tyr Asp Ile Tyr 
            340                 345                 350         


Arg Ala Gln Arg Val Asn Ala Pro Ser Ile Ile Gly Asn Ala Thr Phe 
        355                 360                 365             


Tyr Gln Tyr Trp Ser Val Arg Gln Ser Lys Arg Val Gly Gly Thr Ile 
    370                 375                 380                 


Thr Thr Gly Asn His Phe Asp Ala Trp Ala Ser Val Gly Leu Asn Leu 
385                 390                 395                 400 


Gly Thr His Asn Tyr Gln Ile Met Ala Thr Glu Gly Tyr Gln Ser Ser 
                405                 410                 415     


Gly Ser Ser Asp Ile Thr Val Ser Arg Asp Val Glu Thr Gly Glu Val 
            420                 425                 430         


Leu Trp Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr 
        435                 440                 445             


Phe Asp Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu 
    450                 455                 460                 


Val Val His Asn Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
465                 470                 475                 480 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                485                 490                 495     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  130
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S196

<400>  130

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    130                 135                 140                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
145                 150                 155                 160 


Ile Gly Val Leu Gly Val Ala Pro Cys Leu Ala Glu Gly Ser Leu Val 
                165                 170                 175     


Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys Val Arg Pro 
            180                 185                 190         


Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val 
        195                 200                 205             


Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val Val Arg Leu 
    210                 215                 220                 


Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp His Pro Leu 
225                 230                 235                 240 


Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr 
                245                 250                 255     


Pro Ile Ala Val Ala Gln Thr Cys Leu Thr Ser Pro Gln Thr Gly Phe 
            260                 265                 270         


His Asn Gly Phe Phe Tyr Ser Phe Trp Lys Asp Ser Pro Gly Thr Val 
        275                 280                 285             


Asn Phe Cys Leu Leu Glu Gly Gly Arg Tyr Thr Ser Asn Trp Ser Gly 
    290                 295                 300                 


Ile Asn Asn Trp Val Gly Gly Lys Gly Trp Gln Thr Gly Ser Arg Arg 
305                 310                 315                 320 


Asn Ile Thr Tyr Ser Gly Ser Phe Asn Thr Pro Gly Asn Gly Tyr Leu 
                325                 330                 335     


Ala Leu Tyr Gly Trp Thr Thr Asn Pro Leu Val Glu Tyr Tyr Val Val 
            340                 345                 350         


Asp Ser Trp Gly Ser Trp Arg Pro Pro Gly Ser Asp Gly Thr Phe Leu 
        355                 360                 365             


Gly Thr Val Asn Ser Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Ala Gln 
    370                 375                 380                 


Arg Val Asn Ala Pro Ser Ile Ile Gly Asn Ala Thr Phe Tyr Gln Tyr 
385                 390                 395                 400 


Trp Ser Val Arg Gln Ser Lys Arg Val Gly Gly Thr Ile Thr Thr Gly 
                405                 410                 415     


Asn His Phe Asp Ala Trp Ala Ser Val Gly Leu Asn Leu Gly Thr His 
            420                 425                 430         


Asn Tyr Gln Ile Met Ala Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser 
        435                 440                 445             


Asp Ile Thr Val Ser Arg Asp Val Glu Thr Gly Glu Val Leu Trp Asp 
    450                 455                 460                 


Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu 
465                 470                 475                 480 


Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val Val His 
                485                 490                 495     


Asn Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  131
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S208

<400>  131

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    130                 135                 140                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
145                 150                 155                 160 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
                165                 170                 175     


Val Leu Gly Ala Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala 
            180                 185                 190         


Thr Gly Gln Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val 
        195                 200                 205             


Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu 
    210                 215                 220                 


Val Leu Glu Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser 
225                 230                 235                 240 


Gly Arg Thr Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu 
                245                 250                 255     


Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val 
            260                 265                 270         


Ala Gln Thr Cys Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe 
        275                 280                 285             


Phe Tyr Ser Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu 
    290                 295                 300                 


Leu Glu Gly Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp 
305                 310                 315                 320 


Val Gly Gly Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr 
                325                 330                 335     


Ser Gly Ser Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly 
            340                 345                 350         


Trp Thr Thr Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly 
        355                 360                 365             


Ser Trp Arg Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn 
    370                 375                 380                 


Ser Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala 
385                 390                 395                 400 


Pro Ser Ile Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg 
                405                 410                 415     


Gln Ser Lys Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp 
            420                 425                 430         


Ala Trp Ala Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile 
        435                 440                 445             


Met Ala Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val 
    450                 455                 460                 


Ser Arg Asp Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala 
465                 470                 475                 480 


Val Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro 
                485                 490                 495     


Phe Ala Asn Phe Val Ser Glu Asp Leu Val Val His Asn Ser Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        515                 520                 525             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  132
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S239

<400>  132

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    130                 135                 140                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
145                 150                 155                 160 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
                165                 170                 175     


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
            180                 185                 190         


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
        195                 200                 205             


Gly Ser Pro Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr 
    210                 215                 220                 


Gly Gln Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe 
225                 230                 235                 240 


Ser Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val 
                245                 250                 255     


Leu Glu Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly 
            260                 265                 270         


Arg Thr Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly 
        275                 280                 285             


Trp Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Ala 
    290                 295                 300                 


Gln Thr Cys Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe Phe 
305                 310                 315                 320 


Tyr Ser Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu Leu 
                325                 330                 335     


Glu Gly Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp Val 
            340                 345                 350         


Gly Gly Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser 
        355                 360                 365             


Gly Ser Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp 
    370                 375                 380                 


Thr Thr Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser 
385                 390                 395                 400 


Trp Arg Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn Ser 
                405                 410                 415     


Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro 
            420                 425                 430         


Ser Ile Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln 
        435                 440                 445             


Ser Lys Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp Ala 
    450                 455                 460                 


Trp Ala Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile Met 
465                 470                 475                 480 


Ala Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val Ser 
                485                 490                 495     


Arg Asp Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val 
            500                 505                 510         


Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe 
        515                 520                 525             


Ala Asn Phe Val Ser Glu Asp Leu Val Val His Asn Ser Pro Ser Ala 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  133
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T243

<400>  133

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    130                 135                 140                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
145                 150                 155                 160 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
                165                 170                 175     


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
            180                 185                 190         


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
        195                 200                 205             


Gly Ser Pro Ser Pro Ser Ala Cys Leu Ala Glu Gly Ser Leu Val Leu 
    210                 215                 220                 


Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys Val Arg Pro Gly 
225                 230                 235                 240 


Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro 
                245                 250                 255     


Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val Val Arg Leu Arg 
            260                 265                 270         


Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp His Pro Leu Leu 
        275                 280                 285             


Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro 
    290                 295                 300                 


Ile Ala Val Ala Gln Thr Cys Leu Thr Ser Pro Gln Thr Gly Phe His 
305                 310                 315                 320 


Asn Gly Phe Phe Tyr Ser Phe Trp Lys Asp Ser Pro Gly Thr Val Asn 
                325                 330                 335     


Phe Cys Leu Leu Glu Gly Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile 
            340                 345                 350         


Asn Asn Trp Val Gly Gly Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn 
        355                 360                 365             


Ile Thr Tyr Ser Gly Ser Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala 
    370                 375                 380                 


Leu Tyr Gly Trp Thr Thr Asn Pro Leu Val Glu Tyr Tyr Val Val Asp 
385                 390                 395                 400 


Ser Trp Gly Ser Trp Arg Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly 
                405                 410                 415     


Thr Val Asn Ser Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg 
            420                 425                 430         


Val Asn Ala Pro Ser Ile Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp 
        435                 440                 445             


Ser Val Arg Gln Ser Lys Arg Val Gly Gly Thr Ile Thr Thr Gly Asn 
    450                 455                 460                 


His Phe Asp Ala Trp Ala Ser Val Gly Leu Asn Leu Gly Thr His Asn 
465                 470                 475                 480 


Tyr Gln Ile Met Ala Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp 
                485                 490                 495     


Ile Thr Val Ser Arg Asp Val Glu Thr Gly Glu Val Leu Trp Asp Pro 
            500                 505                 510         


Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg 
        515                 520                 525             


Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val Val His Asn 
    530                 535                 540                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
545                 550                 555                 560 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  134
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S269

<400>  134

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    130                 135                 140                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
145                 150                 155                 160 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
                165                 170                 175     


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
            180                 185                 190         


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
        195                 200                 205             


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
    210                 215                 220                 


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
225                 230                 235                 240 


Gly Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln 
                245                 250                 255     


Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu 
            260                 265                 270         


Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu 
        275                 280                 285             


Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr 
    290                 295                 300                 


Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys 
305                 310                 315                 320 


Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Ala Gln Thr 
                325                 330                 335     


Cys Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe Phe Tyr Ser 
            340                 345                 350         


Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu Leu Glu Gly 
        355                 360                 365             


Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp Val Gly Gly 
    370                 375                 380                 


Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser Gly Ser 
385                 390                 395                 400 


Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp Thr Thr 
                405                 410                 415     


Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser Trp Arg 
            420                 425                 430         


Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn Ser Asp Gly 
        435                 440                 445             


Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro Ser Ile 
    450                 455                 460                 


Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln Ser Lys 
465                 470                 475                 480 


Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp Ala Trp Ala 
                485                 490                 495     


Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile Met Ala Thr 
            500                 505                 510         


Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val Ser Arg Asp 
        515                 520                 525             


Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro 
    530                 535                 540                 


Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn 
545                 550                 555                 560 


Phe Val Ser Glu Asp Leu Val Val His Asn Ser Ile Ser Tyr Pro Ala 
                565                 570                 575     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  135
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T285

<400>  135

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    130                 135                 140                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
145                 150                 155                 160 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
                165                 170                 175     


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
            180                 185                 190         


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
        195                 200                 205             


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
    210                 215                 220                 


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
225                 230                 235                 240 


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
                245                 250                 255     


Ala Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln 
            260                 265                 270         


Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu 
        275                 280                 285             


Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu 
    290                 295                 300                 


Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr 
305                 310                 315                 320 


Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys 
                325                 330                 335     


Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Ala Gln Thr 
            340                 345                 350         


Cys Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe Phe Tyr Ser 
        355                 360                 365             


Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu Leu Glu Gly 
    370                 375                 380                 


Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp Val Gly Gly 
385                 390                 395                 400 


Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser Gly Ser 
                405                 410                 415     


Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp Thr Thr 
            420                 425                 430         


Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser Trp Arg 
        435                 440                 445             


Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn Ser Asp Gly 
    450                 455                 460                 


Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro Ser Ile 
465                 470                 475                 480 


Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln Ser Lys 
                485                 490                 495     


Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp Ala Trp Ala 
            500                 505                 510         


Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile Met Ala Thr 
        515                 520                 525             


Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val Ser Arg Asp 
    530                 535                 540                 


Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro 
545                 550                 555                 560 


Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn 
                565                 570                 575     


Phe Val Ser Glu Asp Leu Val Val His Asn Thr Asp Gln Asn Asn Asn 
            580                 585                 590         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  136
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S293

<400>  136

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    130                 135                 140                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
145                 150                 155                 160 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
                165                 170                 175     


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
            180                 185                 190         


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
        195                 200                 205             


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
    210                 215                 220                 


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
225                 230                 235                 240 


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
                245                 250                 255     


Ala Thr Asp Gln Asn Asn Asn Arg Ala Cys Leu Ala Glu Gly Ser Leu 
            260                 265                 270         


Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys Val Arg 
        275                 280                 285             


Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr Arg 
    290                 295                 300                 


Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val Val Arg 
305                 310                 315                 320 


Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp His Pro 
                325                 330                 335     


Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu Gly 
            340                 345                 350         


Thr Pro Ile Ala Val Ala Gln Thr Cys Leu Thr Ser Pro Gln Thr Gly 
        355                 360                 365             


Phe His Asn Gly Phe Phe Tyr Ser Phe Trp Lys Asp Ser Pro Gly Thr 
    370                 375                 380                 


Val Asn Phe Cys Leu Leu Glu Gly Gly Arg Tyr Thr Ser Asn Trp Ser 
385                 390                 395                 400 


Gly Ile Asn Asn Trp Val Gly Gly Lys Gly Trp Gln Thr Gly Ser Arg 
                405                 410                 415     


Arg Asn Ile Thr Tyr Ser Gly Ser Phe Asn Thr Pro Gly Asn Gly Tyr 
            420                 425                 430         


Leu Ala Leu Tyr Gly Trp Thr Thr Asn Pro Leu Val Glu Tyr Tyr Val 
        435                 440                 445             


Val Asp Ser Trp Gly Ser Trp Arg Pro Pro Gly Ser Asp Gly Thr Phe 
    450                 455                 460                 


Leu Gly Thr Val Asn Ser Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Ala 
465                 470                 475                 480 


Gln Arg Val Asn Ala Pro Ser Ile Ile Gly Asn Ala Thr Phe Tyr Gln 
                485                 490                 495     


Tyr Trp Ser Val Arg Gln Ser Lys Arg Val Gly Gly Thr Ile Thr Thr 
            500                 505                 510         


Gly Asn His Phe Asp Ala Trp Ala Ser Val Gly Leu Asn Leu Gly Thr 
        515                 520                 525             


His Asn Tyr Gln Ile Met Ala Thr Glu Gly Tyr Gln Ser Ser Gly Ser 
    530                 535                 540                 


Ser Asp Ile Thr Val Ser Arg Asp Val Glu Thr Gly Glu Val Leu Trp 
545                 550                 555                 560 


Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp 
                565                 570                 575     


Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val Val 
            580                 585                 590         


His Asn Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        595                 600                 605             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  137
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase S317

<400>  137

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    130                 135                 140                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
145                 150                 155                 160 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
                165                 170                 175     


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
            180                 185                 190         


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
        195                 200                 205             


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
    210                 215                 220                 


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
225                 230                 235                 240 


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
                245                 250                 255     


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
            260                 265                 270         


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
        275                 280                 285             


Gly Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln 
    290                 295                 300                 


Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu 
305                 310                 315                 320 


Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu 
                325                 330                 335     


Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr 
            340                 345                 350         


Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys 
        355                 360                 365             


Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Ala Gln Thr 
    370                 375                 380                 


Cys Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe Phe Tyr Ser 
385                 390                 395                 400 


Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu Leu Glu Gly 
                405                 410                 415     


Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp Val Gly Gly 
            420                 425                 430         


Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser Gly Ser 
        435                 440                 445             


Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp Thr Thr 
    450                 455                 460                 


Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser Trp Arg 
465                 470                 475                 480 


Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn Ser Asp Gly 
                485                 490                 495     


Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro Ser Ile 
            500                 505                 510         


Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln Ser Lys 
        515                 520                 525             


Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp Ala Trp Ala 
    530                 535                 540                 


Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile Met Ala Thr 
545                 550                 555                 560 


Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val Ser Arg Asp 
                565                 570                 575     


Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro 
            580                 585                 590         


Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn 
        595                 600                 605             


Phe Val Ser Glu Asp Leu Val Val His Asn Ser Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  138
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T318

<400>  138

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    130                 135                 140                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
145                 150                 155                 160 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
                165                 170                 175     


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
            180                 185                 190         


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
        195                 200                 205             


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
    210                 215                 220                 


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
225                 230                 235                 240 


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
                245                 250                 255     


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
            260                 265                 270         


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
        275                 280                 285             


Gly Ser Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly 
    290                 295                 300                 


Gln Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser 
305                 310                 315                 320 


Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu 
                325                 330                 335     


Glu Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg 
            340                 345                 350         


Thr Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp 
        355                 360                 365             


Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Ala Gln 
    370                 375                 380                 


Thr Cys Leu Thr Ser Pro Gln Thr Gly Phe His Asn Gly Phe Phe Tyr 
385                 390                 395                 400 


Ser Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys Leu Leu Glu 
                405                 410                 415     


Gly Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn Trp Val Gly 
            420                 425                 430         


Gly Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser Gly 
        435                 440                 445             


Ser Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp Thr 
    450                 455                 460                 


Thr Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser Trp 
465                 470                 475                 480 


Arg Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val Asn Ser Asp 
                485                 490                 495     


Gly Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro Ser 
            500                 505                 510         


Ile Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln Ser 
        515                 520                 525             


Lys Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe Asp Ala Trp 
    530                 535                 540                 


Ala Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln Ile Met Ala 
545                 550                 555                 560 


Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr Val Ser Arg 
                565                 570                 575     


Asp Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu 
            580                 585                 590         


Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala 
        595                 600                 605             


Asn Phe Val Ser Glu Asp Leu Val Val His Asn Thr Tyr Ala Ser Leu 
    610                 615                 620                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  139
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct ProSavinase T329

<400>  139

Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu 
1               5                   10                  15      


Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala 
            20                  25                  30          


Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe 
        35                  40                  45              


Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp 
    50                  55                  60                  


Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu 
65                  70                  75                  80  


Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln 
                85                  90                  95      


Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val 
            100                 105                 110         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        115                 120                 125             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    130                 135                 140                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
145                 150                 155                 160 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
                165                 170                 175     


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
            180                 185                 190         


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
        195                 200                 205             


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
    210                 215                 220                 


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
225                 230                 235                 240 


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
                245                 250                 255     


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
            260                 265                 270         


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
        275                 280                 285             


Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Cys Leu Ala 
    290                 295                 300                 


Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile 
305                 310                 315                 320 


Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr 
                325                 330                 335     


Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg 
            340                 345                 350         


Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr 
        355                 360                 365             


Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp 
    370                 375                 380                 


Leu Pro Leu Gly Thr Pro Ile Ala Val Ala Gln Thr Cys Leu Thr Ser 
385                 390                 395                 400 


Pro Gln Thr Gly Phe His Asn Gly Phe Phe Tyr Ser Phe Trp Lys Asp 
                405                 410                 415     


Ser Pro Gly Thr Val Asn Phe Cys Leu Leu Glu Gly Gly Arg Tyr Thr 
            420                 425                 430         


Ser Asn Trp Ser Gly Ile Asn Asn Trp Val Gly Gly Lys Gly Trp Gln 
        435                 440                 445             


Thr Gly Ser Arg Arg Asn Ile Thr Tyr Ser Gly Ser Phe Asn Thr Pro 
    450                 455                 460                 


Gly Asn Gly Tyr Leu Ala Leu Tyr Gly Trp Thr Thr Asn Pro Leu Val 
465                 470                 475                 480 


Glu Tyr Tyr Val Val Asp Ser Trp Gly Ser Trp Arg Pro Pro Gly Ser 
                485                 490                 495     


Asp Gly Thr Phe Leu Gly Thr Val Asn Ser Asp Gly Gly Thr Tyr Asp 
            500                 505                 510         


Ile Tyr Arg Ala Gln Arg Val Asn Ala Pro Ser Ile Ile Gly Asn Ala 
        515                 520                 525             


Thr Phe Tyr Gln Tyr Trp Ser Val Arg Gln Ser Lys Arg Val Gly Gly 
    530                 535                 540                 


Thr Ile Thr Thr Gly Asn His Phe Asp Ala Trp Ala Ser Val Gly Leu 
545                 550                 555                 560 


Asn Leu Gly Thr His Asn Tyr Gln Ile Met Ala Thr Glu Gly Tyr Gln 
                565                 570                 575     


Ser Ser Gly Ser Ser Asp Ile Thr Val Ser Arg Asp Val Glu Thr Gly 
            580                 585                 590         


Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala 
        595                 600                 605             


Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu 
    610                 615                 620                 


Asp Leu Val Val His Asn Thr Pro His Val Ala Gly Ala Ala Ala Leu 
625                 630                 635                 640 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                645                 650                 655     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            660                 665                 670         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680         


<210>  140
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Aae_RIR2

<400>  140

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ile Glu 
            100                 105                 110         


Gly Thr Glu Val Leu Thr Lys Arg Gly Phe Val Asp Phe Arg Glu Leu 
        115                 120                 125             


Arg Glu Asp Asp Leu Val Ala Gln Tyr Asp Ile Glu Thr Gly Glu Ile 
    130                 135                 140                 


Ser Trp Thr Lys Pro Tyr Ala Tyr Val Glu Arg Asp Tyr Glu Gly Ser 
145                 150                 155                 160 


Met Tyr Arg Leu Lys His Pro Lys Ser Asn Trp Glu Val Val Ala Thr 
                165                 170                 175     


Glu Gly His Glu Phe Ile Val Arg Asn Leu Lys Thr Gly Lys Glu Arg 
            180                 185                 190         


Lys Glu Pro Ile Glu Lys Val Lys Leu His Pro Tyr Ser Ala Ile Pro 
        195                 200                 205             


Val Ala Gly Arg Tyr Thr Gly Glu Val Glu Glu Tyr Asp Leu Trp Glu 
    210                 215                 220                 


Leu Val Ser Gly Lys Gly Ile Thr Leu Lys Thr Arg Ser Ala Val Lys 
225                 230                 235                 240 


Asn Lys Leu Thr Pro Ile Glu Lys Leu Leu Ile Val Leu Gln Ala Asp 
                245                 250                 255     


Gly Thr Ile Asp Ser Lys Arg Asn Gly Lys Phe Thr Gly Phe Gln Gln 
            260                 265                 270         


Leu Lys Phe Phe Phe Ser Lys Tyr Arg Lys Ile Asn Glu Phe Glu Lys 
        275                 280                 285             


Ile Leu Asn Glu Cys Ala Pro Tyr Gly Ile Lys Trp Lys Lys Tyr Glu 
    290                 295                 300                 


Arg Gln Asp Gly Ile Ala Tyr Thr Val Tyr Tyr Pro Asn Asp Leu Pro 
305                 310                 315                 320 


Ile Lys Pro Thr Lys Phe Phe Asp Glu Trp Val Arg Leu Asp Glu Ile 
                325                 330                 335     


Thr Glu Glu Trp Ile Arg Glu Phe Val Glu Glu Leu Val Lys Trp Asp 
            340                 345                 350         


Gly His Ile Pro Lys Asp Arg Asn Lys Lys Lys Val Tyr Tyr Tyr Ser 
        355                 360                 365             


Thr Lys Glu Lys Arg Asn Lys Asp Phe Val Gln Ala Leu Cys Ala Leu 
    370                 375                 380                 


Gly Gly Met Arg Thr Val Val Ser Arg Glu Arg Asn Pro Lys Ala Lys 
385                 390                 395                 400 


Asn Pro Val Tyr Arg Ile Trp Ile Tyr Leu Glu Asp Asp Tyr Ile Asn 
                405                 410                 415     


Thr Gln Thr Met Val Lys Glu Glu Phe Tyr Tyr Lys Gly Lys Val Tyr 
            420                 425                 430         


Cys Val Ser Val Pro Lys Gly Asn Ile Val Val Arg Tyr Lys Asp Ser 
        435                 440                 445             


Val Cys Ile Ala Gly Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    450                 455                 460                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
465                 470                 475                 480 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                485                 490                 495     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            500                 505                 510         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        515                 520                 525             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    530                 535                 540                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
545                 550                 555                 560 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                565                 570                 575     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            580                 585                 590         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        595                 600                 605             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    610                 615                 620                 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
625                 630                 635                 640 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
                645                 650                 655     


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
            660                 665                 670         


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
        675                 680                 685             


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695                 700 


<210>  141
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ace_RIR1

<400>  141

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Gln Pro Tyr 
            100                 105                 110         


Ser Ala Pro Val Ser Thr Pro Asp Gly Pro Ile Pro Ile Gly Lys Leu 
        115                 120                 125             


Val Asp Ala Asn Ala Val Gly Glu Lys Val Phe Asp Ala Ser Gly Val 
    130                 135                 140                 


Thr Arg Ile Val Ala Thr Thr Cys Asn Gly Arg Lys Pro Val Leu Arg 
145                 150                 155                 160 


Ile Arg Thr Ser Gly Gly His Val Leu Asp Val Thr Pro Asp His Leu 
                165                 170                 175     


Val Trp Gln Val Val Asp Gln Thr Ala Gly Arg Phe Val Pro Ala Gly 
            180                 185                 190         


Gln Leu Arg Val Gly Asp Arg Leu Glu Trp His Asp Arg Ala Asn Ser 
        195                 200                 205             


Asp Ala Met Val Ala Ala Phe Thr Ala Asp Ser Ala Ala Ala Ala Gln 
    210                 215                 220                 


Pro Gly Gln Ile Val Asp Ile Leu Ala Ile Asp Glu Leu Gly Val Met 
225                 230                 235                 240 


Pro Val Tyr Asp Ile Gln Thr Glu Ser Gly Glu Tyr Leu Ser Asp Gly 
                245                 250                 255     


Ile Arg Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
            260                 265                 270         


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
        275                 280                 285             


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
    290                 295                 300                 


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
305                 310                 315                 320 


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
                325                 330                 335     


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
            340                 345                 350         


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
        355                 360                 365             


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
    370                 375                 380                 


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
385                 390                 395                 400 


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
                405                 410                 415     


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
            420                 425                 430         


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
        435                 440                 445             


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
    450                 455                 460                 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
465                 470                 475                 480 


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
                485                 490                 495     


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            500                 505         


<210>  142
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Aeh_DnaB-2

<400>  142

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Gly 
            100                 105                 110         


Asp Thr Arg Val Leu Leu Ala Asp Gly Gln Arg Val Pro Ile Arg Asp 
        115                 120                 125             


Leu Val Gly Gln Thr Pro Glu Val Ile Ser Val Asn Ala Glu Gly Arg 
    130                 135                 140                 


Leu Glu Pro Ala Lys Thr Asp Leu Val Trp Ser Val Gly Val Arg Pro 
145                 150                 155                 160 


Leu Leu Gln Val Arg Leu Ala Ser Gly Arg Thr Ile Arg Cys Thr Pro 
                165                 170                 175     


Glu His Arg Leu Arg Gly Leu Trp Asp Trp Lys Glu Ala Arg Asp Ile 
            180                 185                 190         


Arg Val Gly Asp Arg Leu Gly Ile Ala Arg Glu Leu Pro Ala Pro Lys 
        195                 200                 205             


Val Thr Lys Arg Trp Ala Glu His Glu Leu Val Leu Leu Ala His Leu 
    210                 215                 220                 


Val Gly Asp Gly Ser Tyr Ile Lys Gly Gln Pro Leu Arg Tyr Thr Thr 
225                 230                 235                 240 


Ala Ser Glu Ala Asn Ser Glu Ala Val Ser Arg Ala Ala Glu Ala Met 
                245                 250                 255     


Gly Ser Thr Val Thr Arg His Pro Gly Arg Gly Gln Trp His Gln Leu 
            260                 265                 270         


Val Ile Ser Gly Asn Gly Asn Arg Trp His Pro Gln Gly Val Gly Lys 
        275                 280                 285             


Trp Leu Lys Gln Leu Gly Val Phe Gly Gln Arg Ser Arg Glu Lys His 
    290                 295                 300                 


Leu Pro Gln Glu Val Phe Gln Leu Asp Asn Asp Gln Leu Ala Leu Phe 
305                 310                 315                 320 


Leu Arg His Leu Trp Ala Thr Asp Gly Ser Ile Thr Gln Gly Ser Ala 
                325                 330                 335     


Gly Arg Pro Arg Ile Tyr Phe Ser Thr Ala Ser Arg His Leu Ile Gln 
            340                 345                 350         


Asp Val Ala Ala Leu Leu Leu Arg Phe Gly Ile Val Gly Arg Thr Lys 
        355                 360                 365             


His Ile Thr His Gly Asp Gly Glu Gly Trp Phe Thr Leu Asp Ile Ser 
    370                 375                 380                 


Gly Ala Val Gln Gln Gln Arg Tyr Leu Glu Lys Ile Gly Ala Phe Gly 
385                 390                 395                 400 


His Gln Ala His Asn Ala Arg Arg Ala Leu Gln His Leu Arg Gly Leu 
                405                 410                 415     


Val Glu Asn Thr Asn Val Asp Thr Leu Pro Glu Glu Val Phe Asn Tyr 
            420                 425                 430         


Ile Arg Glu Arg Met Arg Glu Glu Gly Ile Thr His Arg Gln Met Ala 
        435                 440                 445             


Ala Leu Arg Gly Thr Ala Tyr Gly Gly Ser Ala His Phe Thr Phe Ser 
    450                 455                 460                 


Pro Ser Arg Glu Thr Leu Leu Ser Tyr Ala Asp Ile Leu Asn Asp Gln 
465                 470                 475                 480 


Arg Leu Arg Met Leu Ala Asn Gln His Val Phe Trp Asp Arg Val Val 
                485                 490                 495     


Ser Val Glu Pro Ala Gly Glu Glu Glu Val Phe Asp Leu Thr Val Pro 
            500                 505                 510         


Gly Asn Ala Cys Trp Leu Ala Asp Gly Ile Val Ser His Asn Ser Gly 
        515                 520                 525             


Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu 
    530                 535                 540                 


Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln 
545                 550                 555                 560 


Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu 
                565                 570                 575     


Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr 
            580                 585                 590         


Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile 
        595                 600                 605             


Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn 
    610                 615                 620                 


Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val 
625                 630                 635                 640 


Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn 
                645                 650                 655     


Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met 
            660                 665                 670         


Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln 
        675                 680                 685             


Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser 
    690                 695                 700                 


Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
705                 710                 715                 720 


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
                725                 730                 735     


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
            740                 745                 750         


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
        755                 760                 765             


Ala Ala Thr Arg 
    770         


<210>  143
<211>  959
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Ani-FGSCA4_PRP8

<400>  143

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Asn 
            100                 105                 110         


Gly Thr Gln Leu Leu Arg Tyr Asp Gly Thr Lys Val Asn Val Glu Asp 
        115                 120                 125             


Val Lys Glu Gly Asp Leu Leu Leu Gly Pro Asp Gly Gly Pro Arg Arg 
    130                 135                 140                 


Ala Phe Asn Val Val Ser Gly Lys Asp Arg Leu Tyr Arg Ile Lys Ile 
145                 150                 155                 160 


Asp Gly Asp Lys Glu Asp Leu Val Val Thr Ala Asn His Ile Leu Val 
                165                 170                 175     


Leu His Arg Ala Lys Ala Met Asn Thr Ser Val Cys Phe Asp Arg Ser 
            180                 185                 190         


Lys Glu Gln Gln Gly Gly Ala Gly Glu Gln Leu Asp Ile Ser Glu Val 
        195                 200                 205             


Ser Ala Ala Glu Arg Tyr Asp Thr Val Glu Met Thr Ala Ala Glu Phe 
    210                 215                 220                 


Ala Ala Leu His Pro Gln Glu Arg Ser Trp Tyr Arg Ala Ile Arg Cys 
225                 230                 235                 240 


Pro Gly Phe Glu Leu Pro Glu Gln Asp Val Pro Val Asn Pro Tyr Phe 
                245                 250                 255     


Leu Gly Leu Trp Leu Gly Asp Glu Ser Arg Asn Gln Ser Ala Ile Tyr 
            260                 265                 270         


Ser Asn His Glu Glu Ala Leu Arg Glu Phe Leu Val Ser His Ala Ala 
        275                 280                 285             


Glu Leu Asp Met His Leu Val Tyr His Gly Gln Ser Ala Tyr Ser Thr 
    290                 295                 300                 


Val Cys Asn Lys Asp Arg Pro Thr Asn Lys Arg Ile Gly Pro Ala Asn 
305                 310                 315                 320 


Gln Thr Gln Thr Val Arg Pro Thr Ile Arg Gln Thr Arg Arg Thr Ile 
                325                 330                 335     


Arg Gln Gln Arg Leu Ala Ala Glu His Ala Ala Ala Glu Tyr Thr Thr 
            340                 345                 350         


Gln Arg Glu Thr Ala Ser Leu Thr Pro Leu Leu Glu Ser Pro Thr Ser 
        355                 360                 365             


Asp Lys His Gly Leu Leu Ser Ser Val Glu Thr Pro Gly Arg Leu Ser 
    370                 375                 380                 


Asp Ser Val Thr Thr Glu Leu Pro Met Ser Arg Ser Ala Ser Ala Met 
385                 390                 395                 400 


Arg Ser Ile Arg Thr Ala Ser Gly Leu Ser Glu Phe Asn Asp Val Thr 
                405                 410                 415     


Asn Val Ser Ala Ser Met Pro Asp Ile Gln Asn Ser Gly Ile Lys Asn 
            420                 425                 430         


Gln Gly Arg Ile Ala Lys Val Thr Arg Gln Gln Asp Ser Lys Gly Glu 
        435                 440                 445             


Val Asp Phe Arg Gln Gln Tyr Ser Gln Ala Ile Lys Asp Asp Leu Glu 
    450                 455                 460                 


Leu Leu Glu Thr Asp Ile Glu Asp Asp Val Ala Ser Ser Asp Glu Ile 
465                 470                 475                 480 


Glu Asp Val Cys Val Val Gly Ser Glu Asn Glu Leu Ile Gly Ser Glu 
                485                 490                 495     


Lys Gln Asp Gln Ser Gly Arg Arg Arg Gln Ile His Arg Leu Arg Thr 
            500                 505                 510         


Gly His Arg Gly Tyr Gly Asp Leu Ser Asp Asp Glu Gln Glu Gln Leu 
        515                 520                 525             


Leu Asp Ser Val Val Glu Arg Tyr Ala Gly Asp Ser Arg Leu Asn Thr 
    530                 535                 540                 


Leu Gln Gln Glu Leu Ser Lys Met Gly Ile Leu Asn Pro Glu Thr Gly 
545                 550                 555                 560 


Pro Ile Asn Asp Lys Lys Arg Ile Pro Gln Val Phe Met Gln Asn Ser 
                565                 570                 575     


Arg Ser Val Arg Leu Ser Val Leu Ala Gly Leu Leu Asp Ser Asp Gly 
            580                 585                 590         


Trp Tyr Ile Tyr Pro Glu Asn Met Phe Gly Phe Ala Gln Ser Glu Leu 
        595                 600                 605             


Cys His Lys Glu Leu Phe Trp Asp Val Val Thr Leu Ala Arg Ser Leu 
    610                 615                 620                 


Gly Phe Gly Val Trp Thr Lys Lys Arg Met Met Pro Asp Pro Thr Gly 
625                 630                 635                 640 


Lys Arg Met Ser Pro Met Leu Val Ala Gln Ile Ser Gly Asp Leu Ala 
                645                 650                 655     


Glu Ile Pro Cys Val Leu Ala Arg Lys Lys Ala Met Pro Arg Leu Ile 
            660                 665                 670         


Pro Gln Ser His Ser Phe Ala Ile Lys Asp Ile Ser Leu Glu Ser Glu 
        675                 680                 685             


Ala Thr Glu Trp Ala Gly Phe Arg Val Asp Lys Asp Gln Leu Tyr Leu 
    690                 695                 700                 


Arg His Asp Tyr Val Val Leu His Asn Ser Gly Val Lys Val Ala Val 
705                 710                 715                 720 


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
                725                 730                 735     


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
            740                 745                 750         


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
        755                 760                 765             


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
    770                 775                 780                 


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
785                 790                 795                 800 


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
                805                 810                 815     


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
            820                 825                 830         


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
        835                 840                 845             


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
    850                 855                 860                 


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
865                 870                 875                 880 


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
                885                 890                 895     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            900                 905                 910         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        915                 920                 925             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    930                 935                 940                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
945                 950                 955                 


<210>  144
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ape_APE0745

<400>  144

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Leu Pro Pro 
            100                 105                 110         


Trp Glu Pro Ile Val Val Arg Arg Gly Asp Glu Val Arg Val Thr Ser 
        115                 120                 125             


Ile Gly Glu Phe Val Asp Ser Phe Leu Glu Gly Glu Gly Gly Leu Asp 
    130                 135                 140                 


Ile Gly Gly Leu Gly Tyr Tyr Thr Leu Ser Leu Asp Thr Arg Thr Leu 
145                 150                 155                 160 


Lys Pro Val Trp Arg Arg Ile Arg Gly Val Ile Lys His Arg Ile Arg 
                165                 170                 175     


Gly Arg Leu Leu Arg Val Lys Ala Ser Lys Gly Arg Ser Ile Asp Leu 
            180                 185                 190         


Thr Gly Ser His Ser Ile Tyr Arg Ile Ser Arg Gly Gly Gly Leu Glu 
        195                 200                 205             


Val Val Gly Ser Ser Asp Leu Arg Pro Gly Asp Ser Leu Val Thr Pro 
    210                 215                 220                 


Ala Ser Val Glu Leu Pro Glu Ser Ala Pro Ser Ser Ile Asn Ala Ala 
225                 230                 235                 240 


Arg Glu Leu Trp Ser Arg Gly Val Glu Gly Ile Phe Val Val Gly Leu 
                245                 250                 255     


Pro Gly Glu Ala Ala Gly Tyr Arg Gly Val Glu Arg Ser Arg Gly Tyr 
            260                 265                 270         


Asp Gly Gly His Ala Ile Pro Leu Glu Thr Leu Val Glu Arg Tyr Gly 
        275                 280                 285             


Asp Ser Val Trp Ser Leu Val Ser Gly Ala Lys Leu Ala Val Ser Arg 
    290                 295                 300                 


Gly Ala Ala Gly Asp His Pro Val Pro Ala Thr Ile Pro Leu Asp Thr 
305                 310                 315                 320 


Gly Phe Tyr Leu Leu Leu Gly Phe Ile Val Ser Ala Gly Ser Val Asp 
                325                 330                 335     


Val Glu Gly Gly His Val Thr Val Thr Leu Gly Pro Gly Arg Glu Gly 
            340                 345                 350         


Tyr Val Gly Asp Val Val Glu Ala Val Asn Ser Thr Ala Pro Gly Ala 
        355                 360                 365             


Gly Val Arg Ile Ser Ser Gly Ala Arg Gly Met Glu Val Thr Ile Arg 
    370                 375                 380                 


Ser Arg Val Leu Ser Glu Leu Leu Ala Arg Val Phe Gly Ala Gly Pro 
385                 390                 395                 400 


Gly Pro Asn Arg Asp Ile Pro Ser Ile Val Phe Arg Ala Pro Lys Pro 
                405                 410                 415     


Met Lys Arg Val Phe Leu Lys Gly Leu Tyr Ala Gly Gly Gly Val Phe 
            420                 425                 430         


Asp Arg Ser Ser Gly Ser Leu Ile Tyr Ala Thr Asp Ser Arg Ser Leu 
        435                 440                 445             


Leu Asn Gly Leu Ala Leu Leu Leu Leu Asn Val Gly Ala Gly Gly Tyr 
    450                 455                 460                 


Arg Ile Asp Ser Gly Asp Ser Gly Arg Ala Leu Ala Leu Ile Val Glu 
465                 470                 475                 480 


Asn Ala Gly Arg Leu Asp Ala Ile Gly Glu Val Leu Glu His Leu Gly 
                485                 490                 495     


Phe His Gly Gly Arg Glu Ala Val Gln Gly Val Gly Ala Leu Glu Arg 
            500                 505                 510         


Ala Thr Ala Gly Leu Ala Gly Gln Ala Thr Val Ala Val Gln Arg Pro 
        515                 520                 525             


Ala Thr Arg Gly Gly Pro Gly Val Asp Val Ala Gly Val Thr Gly Leu 
    530                 535                 540                 


Glu His Leu Glu Ala Ser Thr Glu Phe Val Tyr Asp Leu Ser Val Glu 
545                 550                 555                 560 


Gly Asp Glu Asn Phe Phe Ala Gly Leu Gly Trp Ile Leu Val His Asn 
                565                 570                 575     


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
            580                 585                 590         


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
        595                 600                 605             


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
    610                 615                 620                 


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
625                 630                 635                 640 


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
                645                 650                 655     


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
            660                 665                 670         


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
        675                 680                 685             


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
    690                 695                 700                 


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
705                 710                 715                 720 


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
                725                 730                 735     


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
            740                 745                 750         


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
        755                 760                 765             


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
    770                 775                 780                 


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
785                 790                 795                 800 


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
                805                 810                 815     


Ala Glu Ala Ala Thr Arg 
            820         


<210>  145
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Avin_RIR1_BIL

<400>  145

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Pro 
            100                 105                 110         


Glu Thr Leu Val His Thr Ala Asp Gly Pro Arg Pro Ile Arg Asp Leu 
        115                 120                 125             


Gln Gln Gly Asp Leu Val Leu Gly Ile Ser Gly Arg Tyr Arg Glu Val 
    130                 135                 140                 


Thr His Lys Phe Val Tyr Asn Gln Thr Asp Ala Met Leu Ala Ile Arg 
145                 150                 155                 160 


Val Lys His Ala Val Glu Pro Ile Glu Val Thr Ala Gly His Pro Phe 
                165                 170                 175     


Tyr Ala Ile Arg Gly Val Pro Leu Glu Gln Ser Gly Glu Arg Thr Leu 
            180                 185                 190         


Arg Gln Leu Glu Ser Gly Lys Arg Ser Pro Glu Trp Ile Asp Ala Gly 
        195                 200                 205             


Glu Leu Glu Arg Gly Asp Tyr Met Ala Gln Val Ile Pro Ser Glu Val 
    210                 215                 220                 


Val Pro Val Ala Gly Phe Asp Glu Asp Asp Ala Arg Leu Tyr Gly Ile 
225                 230                 235                 240 


Leu Leu Gly Asp Gly His Leu Ser Lys Asn Gly Leu Gln Trp Gly Val 
                245                 250                 255     


Ser Gly His Pro Gln Arg Asp Gly His Met Asp Phe Val Arg Ala Tyr 
            260                 265                 270         


Leu Ser Ala Arg Gly Ile His Phe Trp Glu Thr Ala Arg Asp Glu Thr 
        275                 280                 285             


Tyr Gly Gln Ile His Trp Ala Ser Gly Arg Gly Val Arg Arg Asp Ala 
    290                 295                 300                 


Thr Thr Gly Arg Ile Thr Gly Ala Gly Ala Ala Thr Leu Pro Phe Glu 
305                 310                 315                 320 


His Ala Asp Leu Tyr Asp Glu Gln Gly Arg Lys Arg Ile Ala Arg Arg 
                325                 330                 335     


Phe Ser His Leu Pro Arg Gln Gln Ser Leu Ala Leu Ile Arg Ser Leu 
            340                 345                 350         


Leu Glu Ser Asp Gly Gly Val Ser Arg Gly Lys Glu Ile Tyr Phe Thr 
        355                 360                 365             


Asn Thr Ser Arg Pro Leu Ile Glu Gly Leu Arg Tyr Gln Leu Leu Arg 
    370                 375                 380                 


Leu Gly Val Pro Thr Ala Gly Gln Tyr Arg Glu Arg Arg Gln Asp His 
385                 390                 395                 400 


Val Gly Gln Arg Ala Asp Gly Ser Pro Ile Arg Phe Glu Gly Val Cys 
                405                 410                 415     


Lys Ala Tyr Asp Leu Arg Ile Pro Ala Val Pro Glu Val Ala Gln Leu 
            420                 425                 430         


Val Gly Cys Gln Pro Ile Ala Lys Arg Asn Trp Ile Thr Trp Gln Gly 
        435                 440                 445             


Cys Val Tyr Ser Arg Ile Arg Asp Val Gln Pro Ile Ala Val Lys Pro 
    450                 455                 460                 


Phe Val Phe Asp Leu Lys Val Glu Gly Asp Glu Ser Tyr Met Thr Thr 
465                 470                 475                 480 


Ser Gly Leu Ala His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
                485                 490                 495     


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
            500                 505                 510         


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
        515                 520                 525             


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
    530                 535                 540                 


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
545                 550                 555                 560 


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
                565                 570                 575     


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
            580                 585                 590         


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
        595                 600                 605             


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
    610                 615                 620                 


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
625                 630                 635                 640 


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
                645                 650                 655     


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
            660                 665                 670         


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
        675                 680                 685             


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
    690                 695                 700                 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
705                 710                 715                 720 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730         


<210>  146
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Bde-JEL197_RPB2

<400>  146

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ser Gly 
            100                 105                 110         


Asp Thr Glu Val Val Leu Gly Asn Gly Met Asp Val Val Leu Leu Thr 
        115                 120                 125             


Asp Leu Val Asp Gly Ala Cys Val Ser Thr Ile Glu Pro Arg Thr Gly 
    130                 135                 140                 


Val Val Ser Pro Ser Leu Ile Asp His Tyr Phe Ala Lys Asp Ala Thr 
145                 150                 155                 160 


Arg Val Leu Lys Ile Thr Leu Asp Asp Gly Arg Val Ile Lys Ala Asp 
                165                 170                 175     


Pro Glu His Pro Leu Phe Ala Ala Lys Val Asp Glu Thr Thr Arg Gly 
            180                 185                 190         


Leu Thr Gly Gln Trp Leu Arg Val Glu Glu Leu Thr Val Gly His His 
        195                 200                 205             


Ala Leu Leu Val Ser Pro Gln Gln Ala Tyr Cys Thr Ser Glu Gln Trp 
    210                 215                 220                 


Thr Leu Thr Leu Ser Glu Lys Glu Val Cys Thr Ala Ser Thr Ala Gln 
225                 230                 235                 240 


Leu Ala Lys Gln Leu Ser Glu Ile Gly Leu Val Gly Val Pro Ile Pro 
                245                 250                 255     


Leu Ser Lys Val Lys Ser Ala Ala Arg Leu Phe Gly Leu Val Leu Ser 
            260                 265                 270         


Ala Gly Asp Phe Ser Gly Lys Leu Tyr Val Glu Lys Asp Glu Asp Val 
        275                 280                 285             


Thr Ala Val Asn Ser Asp Leu Thr Ala Leu Gly Phe Ser Pro Ala His 
    290                 295                 300                 


Trp Val Arg Tyr Gln Asp Asp Gln Gln Lys Trp Phe Lys Cys Asp Asp 
305                 310                 315                 320 


Ser Asn Gly Lys Ala Ile Cys Ile Thr Leu Val Pro Thr Ala Asn Ala 
                325                 330                 335     


Leu Leu Gln Thr Leu Gly Ala His Asp Ala Glu Lys Gln His Arg Tyr 
            340                 345                 350         


Cys Leu Leu Pro Lys Trp Leu Leu Asp Ala Pro Thr Ser Ile Lys Arg 
        355                 360                 365             


Glu Phe Leu Gly Ala Leu Phe Gly Gly Asn Gly Ala His Ile Thr Ile 
    370                 375                 380                 


Ser Cys Asn Glu Gly Lys Trp Glu Pro Thr Met Ser Ala Leu Thr Gln 
385                 390                 395                 400 


His Thr Asp Ala Asp His Leu Glu Ser Thr Val Val Tyr Leu Lys Gln 
                405                 410                 415     


Val Ala Thr Leu Leu Gly Met Leu Asn Ile Cys Ser Ser Val Ser Ser 
            420                 425                 430         


Glu Lys His Ile Thr Ala Glu Lys Thr Gly Tyr Ala Val His Leu His 
        435                 440                 445             


Val Asp Asn Thr Ala Glu Asn Leu Val Arg Phe Tyr Glu Gln Val Gly 
    450                 455                 460                 


Tyr Arg Tyr Cys Phe Asn Lys Thr Ser Gln Ser Ser Ala Pro Val Gln 
465                 470                 475                 480 


Trp Ile Lys Gly Ser Leu Phe Phe Ile Glu Gln His Arg Ser Lys Cys 
                485                 490                 495     


Gln His Ala Phe Glu Leu Leu His Thr Gly Leu Gly Thr Lys Ala Ala 
            500                 505                 510         


Val Ser Ala Glu Ile Asn Met Pro His His Asn Pro Ser His Met Leu 
        515                 520                 525             


Asn Val Lys Glu Ile Pro Thr Ala Pro Ala Asp Glu Tyr Ile Thr Trp 
    530                 535                 540                 


Ile Glu Phe Lys Asp Arg Tyr Val His Lys Glu Ser Pro Arg Phe Val 
545                 550                 555                 560 


Trp Val Thr Ile His Ser Ile Glu Glu Ala Pro Ala Glu Arg Leu Tyr 
                565                 570                 575     


Asp Phe Asn Thr Val Ser Gln Asn His Ser Phe Phe Ala Asn Ser Ile 
            580                 585                 590         


Val Ser His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        595                 600                 605             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    610                 615                 620                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
625                 630                 635                 640 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                645                 650                 655     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            660                 665                 670         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        675                 680                 685             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    690                 695                 700                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
705                 710                 715                 720 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                725                 730                 735     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            740                 745                 750         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        755                 760                 765             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    770                 775                 780                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
785                 790                 795                 800 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                805                 810                 815     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            820                 825                 830         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840         


<210>  147
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Bde-JEL423_eIF-5B

<400>  147

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Gly Arg 
            100                 105                 110         


Asp Thr Pro Leu Leu Met Ala Asp Gly Thr Thr Lys Phe Val Gln Asp 
        115                 120                 125             


Ile Lys Ala Leu Asp Gln Leu Met Gly Asp Asp Cys Thr Pro Arg Ile 
    130                 135                 140                 


Val Gln Glu Arg Ser Leu Val His Glu Ser Gly Ala Leu Tyr Arg Val 
145                 150                 155                 160 


Val Pro Lys Asn Ala Asn Gly His Asp Ala Phe Val Cys Asn Lys Glu 
                165                 170                 175     


His Ile Leu Val Met Val Asn Val Lys Gln Pro Trp Val Ser Gln Thr 
            180                 185                 190         


Val Ile Asp Gly Val Asp Gln Phe His Val Ser Glu Val Val Cys Ile 
        195                 200                 205             


Gly Asn Ile Pro Thr Val Arg Ser Ser Gly Asn Phe Ala Ser Ala Val 
    210                 215                 220                 


Glu Ala Thr Lys Ala Leu Pro Ala Trp Thr Leu Leu Ile Trp Glu Ile 
225                 230                 235                 240 


Ser Val Leu Glu Tyr Leu Ala Val Asp Ala Asp Leu Arg Gln His Phe 
                245                 250                 255     


Met Ile Tyr Lys Pro Ala Gly Gly Ile Glu Tyr Pro Thr Thr Thr Asn 
            260                 265                 270         


Leu Asp Ile Val Gln His Phe Gly Ala Glu Ser Val Pro Asn Leu Glu 
        275                 280                 285             


His Ala Val Met Trp Cys Ile Gly Leu Trp Ile Leu Leu Gly Asp Val 
    290                 295                 300                 


Asp Thr Ala Gly Asn Pro Val Leu Ile Leu Ser Gly Ile Asp His Leu 
305                 310                 315                 320 


His Pro Leu Ile Lys Thr Leu His Ser His Ser Gln Lys Leu Ser Ile 
                325                 330                 335     


Ser Phe Thr Asn Gln Leu Asp Glu Gly Val Ala Asp Ile Ser Lys Pro 
            340                 345                 350         


Thr Ile Ile Ala Leu Gly Asp Lys Phe Gly Leu Leu Phe Lys Ser Leu 
        355                 360                 365             


Gly Ile Glu Ser Ala Glu Cys Ile Pro Asp Ala Leu Leu Arg Ser Ser 
    370                 375                 380                 


Lys Leu His Arg Ala Ala Leu Leu Ala Gly Leu Val Glu Gly Ser Asn 
385                 390                 395                 400 


Ala Phe Ser Ile Val Lys Asp Thr Pro Lys His Trp Asp Ile Ser Cys 
                405                 410                 415     


Lys Asn Asn Met Ile Phe Glu Asn Ile Lys Arg Leu Ser Ser Ser Leu 
            420                 425                 430         


Gly Leu Cys Val Asp Thr Val Thr Pro Ala Thr Ile Thr Gln Gln Val 
        435                 440                 445             


Ser Val Lys Thr Leu Gln Ile Arg Ile Ser Gly Pro Arg Met His Tyr 
    450                 455                 460                 


Val Ser Glu Leu Ile Ser Asn Asp Ser Leu Lys Thr Thr Ser Val Val 
465                 470                 475                 480 


Ser Ile Asp Ser Trp Leu Asn Val Lys Ser Asn Ala Cys Glu Phe Glu 
                485                 490                 495     


Ile Glu Ser Ile Gly Cys Gly Glu Tyr Phe Gly Phe Thr Val Met Gly 
            500                 505                 510         


Pro Asn Ser Arg Phe Leu Leu Gly Asp Phe Thr Val Thr His Asn Ser 
        515                 520                 525             


Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp 
    530                 535                 540                 


Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr 
545                 550                 555                 560 


Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala 
                565                 570                 575     


Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu 
            580                 585                 590         


Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser 
        595                 600                 605             


Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala 
    610                 615                 620                 


Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala 
625                 630                 635                 640 


Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly 
                645                 650                 655     


Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
            660                 665                 670         


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
        675                 680                 685             


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
    690                 695                 700                 


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
705                 710                 715                 720 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                725                 730                 735     


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            740                 745                 750         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        755                 760                 765             


Glu Ala Ala Thr Arg 
    770             


<210>  148
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:BsuP-M1918_RIR1

<400>  148

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Gly 
            100                 105                 110         


Glu Thr Leu Leu Leu Thr Glu Asn Gly Tyr Glu Lys Ala Ala Asp Leu 
        115                 120                 125             


Tyr Lys Lys Gln Asn Asn Leu Lys Val Val Ile Asp Asn Arg Thr Lys 
    130                 135                 140                 


Asp Phe Ala Val Asp Ser Lys Gly Thr Thr Ile Val Asp Ala Ile Pro 
145                 150                 155                 160 


Met Gln Leu Thr Lys Lys Asp Ala Glu Ile Phe Lys Val Lys Thr Lys 
                165                 170                 175     


Gln Gly Tyr Glu Ile Arg Ala Thr Glu Trp His Lys Phe Tyr Val Lys 
            180                 185                 190         


Arg Asp Gly Glu Ile Gln Lys Leu Gln Leu Asn Gln Leu Lys Thr Gly 
        195                 200                 205             


Asp Lys Leu Leu Val Gln Ser Ala Glu Gly Ala Tyr Gly Lys Ile His 
    210                 215                 220                 


Glu Pro Asp Leu Ala Tyr Ile Met Gly Ile Ile Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Ile Thr Glu Lys Thr Ala Lys Ile Tyr Leu Tyr Asp Asn Lys Lys Val 
                245                 250                 255     


Leu Glu Gln Lys Val Thr Asp Ala Val His Arg Ile Ile His Lys His 
            260                 265                 270         


Lys Val Asp Arg Ala Tyr Lys His Asn Thr Ser Leu Leu Pro Thr Phe 
        275                 280                 285             


Asn Met Ala Asn Pro Glu Lys Gln Asp Leu Leu Tyr Met Asn Ser Thr 
    290                 295                 300                 


Val Leu Phe Asp Ile Leu Lys Lys Phe Gly Met Asn Lys Glu Arg Lys 
305                 310                 315                 320 


Thr Arg Val Pro Glu Phe Ile Phe Gln Ala Asn Lys Glu Thr Gln Ala 
                325                 330                 335     


Ala Tyr Leu Ser Gly Leu Phe Gln Thr Asp Gly Cys Val Asn Ala Asn 
            340                 345                 350         


His Lys Ala Lys Ala Leu Thr Ile Glu Leu Thr Ser Ile His Tyr Glu 
        355                 360                 365             


Ser Leu Gln Asp Val Gln Lys Leu Leu Leu Asn Met Gly Val Tyr Thr 
    370                 375                 380                 


Thr Ile Tyr Ser Asn Asn Lys Arg Ser Gln Glu Leu Leu Pro Asp Gly 
385                 390                 395                 400 


Lys Gly Gly Ser Lys Leu Tyr Asn Val Lys Pro Thr His Lys Ile Ser 
                405                 410                 415     


Ile Gln Asp Arg Asn Ser Arg Glu Leu Phe Met Ser Ile Val Glu Leu 
            420                 425                 430         


Lys Asp Tyr Asp Val Tyr Lys Phe Asn Leu Leu Thr Glu Thr Leu Gln 
        435                 440                 445             


Pro Lys Ser Arg Lys Pro Lys His Asp Phe Thr Ala Glu Ile Ile Ser 
    450                 455                 460                 


Ile Glu Glu Asp Gly Val Glu Asp Val Tyr Asp Thr Thr Gln Glu Asp 
465                 470                 475                 480 


Tyr His Ser Leu Ile Phe Asn Gly Ile Val Thr Gly Asn Ser Gly Val 
                485                 490                 495     


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
            500                 505                 510         


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
        515                 520                 525             


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
    530                 535                 540                 


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
545                 550                 555                 560 


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
                565                 570                 575     


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
            580                 585                 590         


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
        595                 600                 605             


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
    610                 615                 620                 


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
625                 630                 635                 640 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
                645                 650                 655     


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
            660                 665                 670         


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
        675                 680                 685             


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
    690                 695                 700                 


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
705                 710                 715                 720 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
                725                 730                 735     


Ala Thr Arg 
            


<210>  149
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Cag_RIR1

<400>  149

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Ala 
            100                 105                 110         


Asp Thr Leu Ile Ala Thr Asp Arg Gly Leu Glu Arg Ile Gly Asn Ile 
        115                 120                 125             


Val Gly Glu Ser Arg Gly Ile Lys Ser Ile Asp Gly Lys Leu His Trp 
    130                 135                 140                 


Val Glu Asn Ile Phe Pro Thr Gly Thr Lys Pro Val Tyr Gln Leu Arg 
145                 150                 155                 160 


Thr Lys Ser Gly Tyr Gln Leu Lys Leu Thr Gly Asp His Val Val Phe 
                165                 170                 175     


Thr Glu Asn Arg Gly Asp Val Lys Ala Cys Glu Leu Arg Lys Asp Asp 
            180                 185                 190         


Met Val Arg Leu Val Gly Ala Pro Phe Gly Lys Glu Thr Thr Gly Ser 
        195                 200                 205             


Thr Asp Ile Ala Gln Leu Ile Gly Leu Leu Thr Gly Asp Gly Cys Ile 
    210                 215                 220                 


Thr Thr Ala Asn Glu Ile Ala Ala Ser Gly Glu Gln Arg Arg Thr Ala 
225                 230                 235                 240 


Phe Leu Thr Val Ser Lys Ala Glu Gln Glu Ile Ala Glu Trp Ala Asn 
                245                 250                 255     


Gln Phe Ile Asn Thr Leu Arg Pro Glu Leu Gly Glu His Asn Lys Ser 
            260                 265                 270         


Gly Ser Val Thr Glu Thr Ala Thr Thr Ala Arg Val Ala Val Gly Ser 
        275                 280                 285             


Pro Arg Ile Leu Lys Gln Phe Glu Ala Phe Ala Val Leu Asp Lys Gly 
    290                 295                 300                 


Ser Val His Lys Leu Phe Thr Asp Lys Val Phe Gln Leu Ala Gln Ser 
305                 310                 315                 320 


Glu Gln Ala Ala Leu Leu Arg Gly Leu Phe Thr Ala Asp Gly Thr Val 
                325                 330                 335     


Ala Asn Tyr Ser Asp Lys Ser Gln Tyr Ile Ala Leu Asp Ala Thr Ser 
            340                 345                 350         


Leu Glu Leu Leu Gln Gln Val Gln Leu Leu Leu Phe Asn Phe Gly Ile 
        355                 360                 365             


Lys Ser Lys Ile Tyr Glu Asn Arg Arg Val Gly Glu Leu Val Ser Leu 
    370                 375                 380                 


Leu Pro Asp Gly Lys Gly Gly Ile Lys Glu Tyr Pro Val Gln Gln Met 
385                 390                 395                 400 


His Ser Leu Arg Ile Ser Arg Ser Ser Arg Ile Leu Phe Glu Gln Gln 
                405                 410                 415     


Ile Gly Phe Met Ala Glu Ser Lys Lys Tyr Glu Ala Leu Ala Glu Leu 
            420                 425                 430         


Asn Arg Thr Val Ser Thr Tyr Arg Asp Ser Ala Tyr Asp Ala Val Ala 
        435                 440                 445             


Ser Leu Thr Tyr Ser Gly Glu Glu Ala Val Phe Asp Leu Thr Glu Pro 
    450                 455                 460                 


Glu Thr Asp His Phe Ile Ala Asn Gly Ile Gly Val His Asn Ser Gly 
465                 470                 475                 480 


Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu 
                485                 490                 495     


Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln 
            500                 505                 510         


Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu 
        515                 520                 525             


Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr 
    530                 535                 540                 


Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile 
545                 550                 555                 560 


Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn 
                565                 570                 575     


Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val 
            580                 585                 590         


Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn 
        595                 600                 605             


Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met 
    610                 615                 620                 


Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln 
625                 630                 635                 640 


Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser 
                645                 650                 655     


Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
            660                 665                 670         


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
        675                 680                 685             


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
    690                 695                 700                 


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
705                 710                 715                 720 


Ala Ala Thr Arg 
                


<210>  150
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Cau_SpoVR

<400>  150

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu His Gly 
            100                 105                 110         


Asp Ser Leu Ile Val Thr Asp His Gly Leu Val Pro Met Arg Glu Val 
        115                 120                 125             


Val Asn His Arg Gln Arg Leu Gln Val Ser Asp Gly Glu Arg Gln Gln 
    130                 135                 140                 


Thr Val Tyr Asp Trp Asn Arg Phe Ala Asp Tyr Pro Thr Val Thr Met 
145                 150                 155                 160 


Arg Thr Arg Ala Gly Phe Thr Leu Thr Gly Ser His Asn His Arg Ile 
                165                 170                 175     


Met Leu Ala Asp Gly Thr Trp Arg Arg Leu Asp Glu Leu Gln Ile Gly 
            180                 185                 190         


Asp Arg Val Arg Ile Ala Gly Gly Thr Glu Leu Trp Ala Thr Glu Pro 
        195                 200                 205             


Ala Leu Leu Arg Cys Arg Arg Pro Leu Pro Arg Val Leu Val Thr Ala 
    210                 215                 220                 


Gly Ala Pro Ala Ala Thr Thr Ser Ser Pro His Arg Arg Gly Tyr Arg 
225                 230                 235                 240 


Arg Ala Ala Ala Val Val Val Asp Glu Lys Leu Ala Ala Ala Ile Gly 
                245                 250                 255     


Arg Arg Cys Val Thr His Ala Asp Gln Gln Ala Leu Asp Ala Ile Arg 
            260                 265                 270         


Arg Ser Pro Arg Pro Gln Val Val Ala Phe Leu Arg Ala Phe Cys Gln 
        275                 280                 285             


Gly Ala Gly Gln Ser Val Ala Ser Gly Leu Thr Leu Thr Cys Ala Asp 
    290                 295                 300                 


Ala Asp Leu Ala Thr Thr Val Gln Leu Leu Leu Thr Asn Leu Gly Val 
305                 310                 315                 320 


Leu Ala His Arg Thr Asp Thr Thr Val Arg Ile Asp Asn Gly Asp Asp 
                325                 330                 335     


Leu Glu Arg Ala Tyr Thr Thr Leu Ala Thr Pro Thr Gly Trp Thr Asp 
            340                 345                 350         


Glu Val Val Ala Leu Glu His Gly Thr Ala Asp Val Tyr Asp Ile Ser 
        355                 360                 365             


Val Thr Ala Thr His Arg Tyr Ala Ala Gln Gly Phe Ile Asn His Asn 
    370                 375                 380                 


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
385                 390                 395                 400 


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
                405                 410                 415     


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
            420                 425                 430         


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
        435                 440                 445             


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
    450                 455                 460                 


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
465                 470                 475                 480 


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
                485                 490                 495     


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
            500                 505                 510         


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
        515                 520                 525             


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
    530                 535                 540                 


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
545                 550                 555                 560 


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
                565                 570                 575     


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
            580                 585                 590         


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
        595                 600                 605             


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
    610                 615                 620                 


Ala Glu Ala Ala Thr Arg 
625                 630 


<210>  151
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Cbu_DnaB

<400>  151

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Gly 
            100                 105                 110         


Asp Thr Leu Ile Cys Leu Ala Asp Gly Arg Arg Val Pro Ile Gln Asp 
        115                 120                 125             


Leu Val Gly His Ser Pro Glu Val Ile Ala Val Asp Asp Lys Gly Arg 
    130                 135                 140                 


Leu Val Cys Ala Lys Ser Glu Val Ile Trp Lys Val Gly Glu Arg Ser 
145                 150                 155                 160 


Val Phe Glu Ile Lys Leu Ala Ser Gly Arg Ser Ile Lys Ala Thr Ala 
                165                 170                 175     


Glu His Arg Leu Leu Ala Phe Lys Gly Trp Arg His Val Lys Asp Phe 
            180                 185                 190         


Lys Val Gly Asp Arg Leu Ala Ile Ala His Gln Val Pro Glu Pro Asp 
        195                 200                 205             


Arg Leu Leu Gln His Cys Gln Ser Asp Leu Phe Trp Asp Arg Ile Val 
    210                 215                 220                 


Ser Ile Glu Glu Lys Gly Ser Glu Glu Val Tyr Asp Leu Thr Val Pro 
225                 230                 235                 240 


Lys Tyr Ala Ser Trp Leu Ala Asp Gly Val Val Ser His Asn Ser Gly 
                245                 250                 255     


Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu 
            260                 265                 270         


Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln 
        275                 280                 285             


Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu 
    290                 295                 300                 


Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr 
305                 310                 315                 320 


Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile 
                325                 330                 335     


Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn 
            340                 345                 350         


Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val 
        355                 360                 365             


Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn 
    370                 375                 380                 


Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met 
385                 390                 395                 400 


Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln 
                405                 410                 415     


Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser 
            420                 425                 430         


Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
        435                 440                 445             


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
    450                 455                 460                 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
465                 470                 475                 480 


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
                485                 490                 495     


Ala Ala Thr Arg 
            500 


<210>  152
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ceu_ClpP

<400>  152

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Ser 
            100                 105                 110         


Asp His Thr Val Leu Thr Thr Arg Gly Trp Ile Pro Ile Ala Asp Val 
        115                 120                 125             


Thr Leu Asp Asp Lys Val Ala Val Leu Asp Asn Asn Thr Gly Glu Met 
    130                 135                 140                 


Ser Tyr Gln Asn Pro Gln Lys Val His Lys Tyr Asp Tyr Glu Gly Pro 
145                 150                 155                 160 


Met Tyr Glu Val Lys Thr Ala Gly Val Asp Leu Phe Val Thr Pro Asn 
                165                 170                 175     


His Arg Met Tyr Val Asn Thr Thr Asn Asn Thr Thr Asn Gln Asn Tyr 
            180                 185                 190         


Asn Leu Val Glu Ala Ser Ser Ile Phe Gly Lys Lys Val Arg Tyr Lys 
        195                 200                 205             


Asn Asp Ala Ile Trp Asn Lys Thr Asp Tyr Gln Phe Ile Leu Pro Glu 
    210                 215                 220                 


Thr Ala Thr Leu Thr Gly His Thr Asn Lys Ile Ser Ser Thr Pro Ala 
225                 230                 235                 240 


Ile Gln Pro Glu Met Asn Ala Trp Leu Thr Phe Phe Gly Leu Trp Ile 
                245                 250                 255     


Ala Asn Gly His Thr Thr Lys Ile Ala Glu Lys Thr Ala Glu Asn Asn 
            260                 265                 270         


Gln Gln Lys Gln Arg Tyr Lys Val Ile Leu Thr Gln Val Lys Glu Asp 
        275                 280                 285             


Val Cys Asp Ile Ile Glu Gln Thr Leu Asn Lys Leu Gly Phe Asn Phe 
    290                 295                 300                 


Ile Arg Ser Gly Lys Asp Tyr Thr Ile Glu Asn Lys Gln Leu Trp Ser 
305                 310                 315                 320 


Tyr Leu Asn Pro Phe Asp Asn Gly Ala Leu Asn Lys Tyr Leu Pro Asp 
                325                 330                 335     


Trp Val Trp Glu Leu Ser Ser Gln Gln Cys Lys Ile Leu Leu Asn Ser 
            340                 345                 350         


Leu Cys Leu Gly Asn Cys Leu Phe Thr Lys Asn Asp Asp Thr Leu His 
        355                 360                 365             


Tyr Phe Ser Thr Ser Glu Arg Phe Ala Asn Asp Val Ser Arg Leu Ala 
    370                 375                 380                 


Leu His Ala Gly Thr Thr Ser Thr Ile Gln Leu Glu Ala Ala Pro Ser 
385                 390                 395                 400 


Asn Leu Tyr Asp Thr Ile Ile Gly Leu Pro Val Glu Val Asn Thr Thr 
                405                 410                 415     


Leu Trp Arg Val Ile Ile Asn Gln Ser Ser Phe Tyr Ser Tyr Ser Thr 
            420                 425                 430         


Asp Lys Ser Ser Ala Leu Asn Leu Ser Asn Asn Val Ala Cys Tyr Val 
        435                 440                 445             


Asn Ala Gln Ser Ala Leu Thr Leu Glu Gln Asn Ser Gln Lys Ile Asn 
    450                 455                 460                 


Lys Asn Thr Leu Val Leu Thr Lys Asn Asn Val Lys Ser Gln Thr Met 
465                 470                 475                 480 


His Ser Gln Arg Ala Glu Arg Val Asp Thr Ala Leu Leu Thr Gln Lys 
                485                 490                 495     


Glu Leu Asp Asn Ser Leu Asn His Glu Ile Leu Ile Asn Lys Asn Pro 
            500                 505                 510         


Gly Thr Ser Gln Leu Glu Cys Val Val Asn Pro Glu Val Asn Asn Thr 
        515                 520                 525             


Ser Thr Asn Asp Arg Phe Val Tyr Tyr Lys Gly Pro Val Tyr Cys Leu 
    530                 535                 540                 


Thr Gly Pro Asn Asn Val Phe Tyr Val Gln Arg Asn Gly Lys Ala Val 
545                 550                 555                 560 


Trp Thr Gly Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
                565                 570                 575     


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
            580                 585                 590         


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
        595                 600                 605             


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
    610                 615                 620                 


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
625                 630                 635                 640 


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
                645                 650                 655     


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
            660                 665                 670         


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
        675                 680                 685             


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
    690                 695                 700                 


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
705                 710                 715                 720 


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
                725                 730                 735     


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
            740                 745                 750         


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
        755                 760                 765             


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
    770                 775                 780                 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
785                 790                 795                 800 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                805                 810 


<210>  153
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Chy_RIR1

<400>  153

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Gly 
            100                 105                 110         


Asp Thr Leu Val Phe Thr Asp Lys Gly Leu Ile Glu Ala Arg Lys Leu 
        115                 120                 125             


Glu Val Gly Met Lys Val Trp Ser Gly Asp Gly Trp Asn Glu Ile Lys 
    130                 135                 140                 


Glu Val Ile Asn Asn Gly Val Lys Pro Val Leu Lys Leu Lys Leu Lys 
145                 150                 155                 160 


Thr Gly Leu Glu Ile Lys Val Thr Glu Glu His Lys Ile Phe Thr Gly 
                165                 170                 175     


Glu Gly Trp Lys Glu Ala Lys Asp Leu Lys Val Gly Asp Lys Leu Tyr 
            180                 185                 190         


Leu Pro Val Ser Tyr Pro Glu Leu Asp Phe Pro Val Lys Glu Glu Asn 
        195                 200                 205             


Asp Phe Tyr Glu Phe Leu Gly Tyr Phe Leu Gly Asp Gly Ser Leu Ser 
    210                 215                 220                 


Val Ser Asn His Val Ser Leu His Val Gly Asn Asp Lys Glu Leu Ala 
225                 230                 235                 240 


Leu Tyr Phe Lys Glu Lys Val Glu Lys Tyr Ala Gly Ala Ala Tyr Leu 
                245                 250                 255     


Ile Glu Arg Asp Gly Gln Tyr Ile Ile Asp Val His Arg Lys Glu Phe 
            260                 265                 270         


Ala Glu Lys Ile Lys Lys Ile Phe Gly Ile Glu Ile Thr Asp Ser Lys 
        275                 280                 285             


Glu Lys Asp Ile Pro Ser Ser Leu Leu Ala Val Asn Ser Glu Ala Met 
    290                 295                 300                 


Lys Ala Leu Leu Arg Gly Leu Phe Ser Ala Asp Gly Ser Val Tyr Asp 
305                 310                 315                 320 


Ala Asn Gly Ser Ile Thr Val Ala Leu Ser Ser Thr Ser Tyr Pro Leu 
                325                 330                 335     


Leu Arg Lys Val Gln Ile Leu Leu Leu Ser Leu Gly Ile Pro Ser Thr 
            340                 345                 350         


Leu Thr Gly Glu Lys Asp Gln Asp Val Lys Ile Ile Lys Gly Asn Glu 
        355                 360                 365             


Tyr Glu Thr Leu Pro Thr Tyr Arg Leu Ile Ile Ser Gly Glu Arg Ala 
    370                 375                 380                 


Ser Leu Phe Phe Asn Lys Ile Gly Leu Ile Gly Glu Lys Lys Lys Lys 
385                 390                 395                 400 


Phe Leu Glu Leu Met Ala Gly Lys Thr Thr Tyr Ser Thr Leu Asn Asn 
                405                 410                 415     


His Leu Tyr Gln Glu Ile Val Ser Ile Glu Pro Ala Gly Glu Glu Glu 
            420                 425                 430         


Val Phe Asp Ile Thr Ala Pro Pro Lys Tyr Thr Trp Ile Thr Asn Gly 
        435                 440                 445             


Ile Leu Ser Leu Asp Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
    450                 455                 460                 


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
465                 470                 475                 480 


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
                485                 490                 495     


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
            500                 505                 510         


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
        515                 520                 525             


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
    530                 535                 540                 


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
545                 550                 555                 560 


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
                565                 570                 575     


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
            580                 585                 590         


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
        595                 600                 605             


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
    610                 615                 620                 


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
625                 630                 635                 640 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
                645                 650                 655     


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
            660                 665                 670         


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
        675                 680                 685             


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695                 


<210>  154
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Cth_ATPase_BIL

<400>  154

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Val Ala 
            100                 105                 110         


Gly Thr Met Ile Leu Thr Val Ala Gly Leu Val Ala Ile Glu Asn Ile 
        115                 120                 125             


Lys Ala Gly Asp Lys Val Ile Ala Thr Asn Pro Glu Thr Phe Glu Val 
    130                 135                 140                 


Ala Glu Lys Thr Val Leu Glu Thr Tyr Val Arg Glu Thr Thr Glu Leu 
145                 150                 155                 160 


Leu His Leu Thr Ile Asn Gly Asp Val Ile Lys Thr Thr Phe Glu His 
                165                 170                 175     


Leu Phe Tyr Ala Lys Asp Val Gly Phe Val Glu Ala Lys Glu Leu Gln 
            180                 185                 190         


Val Gly Asp Lys Leu Leu Asp Ser Lys Gly Asn Val Leu Val Val Glu 
        195                 200                 205             


Asp Lys Lys Ile Lys Ile Thr Asp Glu Pro Val Lys Val Tyr Asn Phe 
    210                 215                 220                 


Gln Val Asp Asp Phe His Thr Tyr His Val Gly Cys Asn Gly Val Leu 
225                 230                 235                 240 


Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser 
                245                 250                 255     


Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly 
            260                 265                 270         


Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly 
        275                 280                 285             


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro 
    290                 295                 300                 


Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly 
                325                 330                 335     


Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr 
            340                 345                 350         


Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val 
        355                 360                 365             


Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg 
    370                 375                 380                 


Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg 
385                 390                 395                 400 


Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly 
                405                 410                 415     


Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn 
            420                 425                 430         


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
        435                 440                 445             


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
    450                 455                 460                 


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
465                 470                 475                 480 


Leu Val Asn Ala Glu Ala Ala Thr Arg 
                485                 


<210>  155
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Cth_TerA

<400>  155

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Gln Leu Ala Leu 
            100                 105                 110         


Asp Thr Pro Ile Pro Thr Pro Asp Gly Trp Thr Thr Met Gly Glu Ile 
        115                 120                 125             


Lys Ala Gly Asp Lys Val Ile Asp Glu Lys Gly Arg Pro Cys Asn Val 
    130                 135                 140                 


Val Ala Ile Ser Glu Ile Asp Asp Thr Glu Gln Ala Tyr Lys Ile Asn 
145                 150                 155                 160 


Phe Arg Asp Gly Thr Ser Ile Val Ala Gly Glu Arg His Leu Trp Lys 
                165                 170                 175     


Val Gln Val Thr Asn Asn Gly Arg Arg Glu Lys Leu Leu Thr Thr Gly 
            180                 185                 190         


Glu Met Tyr Gln Lys Gln Phe Lys Thr Lys Ser Lys Glu Asn Arg Ala 
        195                 200                 205             


Leu Phe Arg Ile Pro Ile Ala Asp Ala Phe Ile Leu Pro Glu Asn Lys 
    210                 215                 220                 


Leu Pro Ile Asp Pro Tyr Leu Phe Gly Tyr Trp Ile Gly Asn Gly Asn 
225                 230                 235                 240 


Ala Val Lys Pro Glu Ile Thr Val Met Arg Asp Asp Val Asp Glu Val 
                245                 250                 255     


Ile Lys Asn Ile Pro Tyr Lys Leu His Asn Arg Tyr Lys Gln Glu Gly 
            260                 265                 270         


Asn Ser Asp Ile Leu Val Tyr Lys Glu Leu Lys Ser Ile Leu Val Lys 
        275                 280                 285             


Asn Phe Arg Glu Lys Arg Ile Pro Ile Glu Tyr Leu Arg Ala Ser Ala 
    290                 295                 300                 


Gln Gln Arg Lys Arg Leu Leu Gln Gly Leu Ile Asp Ser Asp Gly Cys 
305                 310                 315                 320 


Val Ser Thr Ala Lys Ser Gln Ala Ile Tyr Val Thr Ile Leu Phe Glu 
                325                 330                 335     


Leu Ala Lys Asp Val Gln Asp Leu Leu Trp Ser Leu Gly Ile Lys Asn 
            340                 345                 350         


Thr Leu Lys Thr Ala Pro Ser Ala Arg Tyr Gly Ile Glu Thr Gly Glu 
        355                 360                 365             


Ile Cys Tyr Leu Ile Lys Phe Thr Ala Phe Asn Asp Leu Glu Val Ser 
    370                 375                 380                 


Gly Leu Asp Arg Lys Leu Lys Arg Gly Arg Glu Arg Asn Ile Lys Thr 
385                 390                 395                 400 


Arg Ser His Phe His Tyr Ile Lys Ser Ile Glu Lys Thr Gly Lys Thr 
                405                 410                 415     


Lys Met Arg Cys Ile Gln Val Asp Ser Pro Ser Arg Leu Tyr Leu Ala 
            420                 425                 430         


Gly Lys Ser Met Ile Pro Thr His Asn Ser Gly Val Lys Val Ala Val 
        435                 440                 445             


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
    450                 455                 460                 


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
465                 470                 475                 480 


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
                485                 490                 495     


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
            500                 505                 510         


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
        515                 520                 525             


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
    530                 535                 540                 


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
545                 550                 555                 560 


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
                565                 570                 575     


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
            580                 585                 590         


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
        595                 600                 605             


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
    610                 615                 620                 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
625                 630                 635                 640 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
                645                 650                 655     


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
            660                 665                 670         


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680                 685         


<210>  156
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:CV-NY2A_RIR1

<400>  156

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ala Gly 
            100                 105                 110         


Asp Thr Lys Ile Leu Thr Ser Ser Gly Tyr His Pro Ile Lys Asp Met 
        115                 120                 125             


Glu Gly Lys Gln Val Arg Val Trp Asn Gly Tyr Glu Phe Ser Glu Thr 
    130                 135                 140                 


Ile Val His Lys Thr Gly Val Asn Gln Lys Leu Ile Met Val Ser Leu 
145                 150                 155                 160 


Asp Asp Gly Thr Glu Leu Arg Cys Thr Pro Tyr His Lys Phe Tyr Ile 
                165                 170                 175     


Glu Thr Gly Ser Arg Pro Ala Asp Lys Ser Arg Val Met Glu Val Arg 
            180                 185                 190         


Ala Gly Asp Leu Glu Lys Gly Asp Arg Ile Ile Arg Phe Glu Leu Pro 
        195                 200                 205             


Thr Ile Thr Val Gly Glu Thr Thr Met Ser Asp Lys Glu Ala Tyr Thr 
    210                 215                 220                 


Lys Gly Phe Phe Ser Ala Asp Gly Cys Val Ile Lys Ser Lys Tyr Gly 
225                 230                 235                 240 


Glu Asp Glu Tyr Arg Ile Ser Val Lys Arg Glu Asp Lys Ile Glu Ala 
                245                 250                 255     


Leu Thr Lys Tyr Val Asp Val Ile Lys Ser His Thr Asn Arg Phe Arg 
            260                 265                 270         


Thr His Phe Tyr Val Pro Asp Tyr Val Gln Asn Lys Phe Glu Val Pro 
        275                 280                 285             


Ile Asn Ser Met Val Asn Glu Lys Ile Ser Trp Leu Ala Gly Phe Met 
    290                 295                 300                 


Asp Gly Asp Gly Cys Val Ile Arg Tyr Lys Asp Ile Glu Asn Met Gln 
305                 310                 315                 320 


Ala Val Ser Ile Asn Lys Ser Phe Leu Gln Asp Ile Arg Leu Met Leu 
                325                 330                 335     


Gln Thr Ile Gly Ile His Ser Thr Ile Asn Lys Phe Met Pro Asn Arg 
            340                 345                 350         


Val Met Lys Met Pro Asp Gly Arg Gly Gly Thr Asp Met Tyr Asn Gly 
        355                 360                 365             


Ala Glu Ser Trp Arg Leu Gln Ile Asp Ser Glu Gly Val Arg Lys Leu 
    370                 375                 380                 


Phe Ala Leu Gly Phe Thr Pro Arg Arg Leu Lys Met Asn Gly Ser Arg 
385                 390                 395                 400 


Lys Arg His His Lys Thr Asn Lys Phe Thr Arg Val Val Ser Val Thr 
                405                 410                 415     


Asp His Gly Asp Val Glu Asp Thr Tyr Cys Phe Asn Glu Pro Lys Arg 
            420                 425                 430         


His Met Gly Val Phe Asn Gly Val Ile Thr Gly Gln Ser Gly Val Lys 
        435                 440                 445             


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
    450                 455                 460                 


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
465                 470                 475                 480 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
                485                 490                 495     


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
            500                 505                 510         


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
        515                 520                 525             


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
    530                 535                 540                 


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
545                 550                 555                 560 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
                565                 570                 575     


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
            580                 585                 590         


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
        595                 600                 605             


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
    610                 615                 620                 


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
625                 630                 635                 640 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
                645                 650                 655     


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
            660                 665                 670         


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
        675                 680                 685             


Thr Arg 
    690 


<210>  157
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Cwa_PEP

<400>  157

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Asp Gly 
            100                 105                 110         


Lys Thr Lys Ile Leu Thr Asn Gln Gly Phe Met Thr Leu Arg Gln Val 
        115                 120                 125             


Tyr Glu Gln Gly Tyr Glu Gly Leu Ser Thr Leu Ser Leu Asn Thr Lys 
    130                 135                 140                 


Thr His Lys Ile Glu Trp Lys Pro Ile Leu Asp Thr Met Lys Arg Gln 
145                 150                 155                 160 


Ser Glu Met Ile Asp Ile Ser Val Ser Gln Thr Gly Arg Ile Thr Asp 
                165                 170                 175     


Asn Thr Leu Arg Leu Thr Pro Asp His Lys Met Val Asn Leu Arg Gly 
            180                 185                 190         


Gly Lys Tyr Thr Lys Thr Glu Ile Gln Asp Leu Leu Lys Gln Gln Glu 
        195                 200                 205             


Met Leu Thr Val Ala Gln Thr Ile Pro Ser Leu Gly Asn Asn Lys His 
    210                 215                 220                 


Gln Glu Ala Asp Leu Ala Tyr Phe Leu Gly Gly Ile Ile Thr Asp Gly 
225                 230                 235                 240 


Ser Ile Tyr Thr Ser Ser Thr Arg Gly Glu Val Gln Phe Ile Gln Lys 
                245                 250                 255     


Asp Val Pro Glu Lys Gln Ala Phe Ile Ser Lys Met Asn Asp Leu Ala 
            260                 265                 270         


Asn Ser Leu Tyr Gly Lys Ser Phe Thr Ala His Ile Lys Pro Val Ser 
        275                 280                 285             


Ser Ser Tyr Ile Arg Gly Gln Lys Val Thr Gly Gln Ala Thr Ala Tyr 
    290                 295                 300                 


Arg Leu His Ser Lys Ala Ile Ala Tyr Asp Val Lys Glu Arg Glu Asn 
305                 310                 315                 320 


Asn Ile Thr Gln Leu Leu Leu Glu Asn Glu Ala Glu Leu Ser Tyr His 
                325                 330                 335     


Phe Leu Gly Gly Val Ile Asp Gly Asp Gly Cys Tyr His Lys Asn Arg 
            340                 345                 350         


Leu His Ile Tyr Ile Ser Glu Glu Asn Leu Leu Gln Ala Val Ile Ile 
        355                 360                 365             


Ala Cys Leu Lys Met Asn Thr Val Pro Gln Val Thr Lys Asn Arg Asn 
    370                 375                 380                 


Ile Tyr His Leu Gln Ile Val Glu Lys Leu Glu Val Ile Leu Arg Tyr 
385                 390                 395                 400 


Thr Gln Arg Val Lys Gly Glu Val Thr Pro Arg Thr Ile Gln Thr Arg 
                405                 410                 415     


Phe Phe Ala Thr Arg Gln Leu Phe Glu Asn Gln Glu Thr Gly Gln Ile 
            420                 425                 430         


Lys Leu Arg Gln Asp Asn Asn Cys Leu Ile Ser Asp Lys Gln Leu Arg 
        435                 440                 445             


Glu Met Gly Glu Phe Glu Glu Leu Ile Asp Gly Asp Thr Arg Met Gln 
    450                 455                 460                 


Arg Val Ile Gln Val Gly Glu Lys Ser Asp Gly Asp Val Tyr Asn Ile 
465                 470                 475                 480 


Thr Val Ala Glu His His Asn Tyr Val Val Phe Thr Ala Lys Tyr Thr 
                485                 490                 495     


Pro Val Val Val Cys Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
            500                 505                 510         


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
        515                 520                 525             


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
    530                 535                 540                 


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
545                 550                 555                 560 


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
                565                 570                 575     


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
            580                 585                 590         


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
        595                 600                 605             


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
    610                 615                 620                 


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
625                 630                 635                 640 


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
                645                 650                 655     


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
            660                 665                 670         


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
        675                 680                 685             


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
    690                 695                 700                 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
705                 710                 715                 720 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
                725                 730                 735     


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            740                 745             


<210>  158
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Cwa_RIR1

<400>  158

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ala Pro 
            100                 105                 110         


Glu Thr Lys Ile Leu Thr Asp Arg Gly Gln Ile Ala Ile Ala Asp Val 
        115                 120                 125             


Ala Gly Glu Lys Val Asn Ile Trp Asn Gly Ser Glu Trp Ser Glu Val 
    130                 135                 140                 


Leu Val Lys Lys Thr Gly Glu Asn Gln Pro Leu Leu Lys Val His Phe 
145                 150                 155                 160 


Ser Asn Gly Glu Ser Leu Asp Cys Thr Tyr Tyr His Lys Phe His Val 
                165                 170                 175     


Gln Glu Asn Tyr Lys Gly Lys Val Lys Ile Val Glu Ala Lys Asp Leu 
            180                 185                 190         


Gln Glu Gly Asp Lys Leu Ile Lys Tyr Arg Leu Pro Leu Val Glu Ser 
        195                 200                 205             


Glu Asn Asp Ile Asp Phe Pro Tyr Ala Tyr Thr Ser Gly Phe Phe Ser 
    210                 215                 220                 


Gly Asp Gly Ser His Asp Gly Met Gly Lys Pro Glu Ile Asp Leu Tyr 
225                 230                 235                 240 


Gly Glu Lys Lys Glu Leu Leu Pro Phe Val Thr Val Arg Asn Lys Tyr 
                245                 250                 255     


Tyr Gly Gly Ser Tyr Gly Asp Lys Ser Trp Arg Ile Glu Arg Asp Glu 
            260                 265                 270         


Val Ala Val Tyr Asp Asp Val Asn Gln Asp Arg Ile Val Cys Lys Leu 
        275                 280                 285             


Pro Leu Asp Ile Pro Ala Lys Phe Thr Val Pro Val Asn Gly Tyr Thr 
    290                 295                 300                 


Ile Gln Ser Arg Leu Glu Trp Leu Ala Gly Leu Leu Asp Ala Asp Gly 
305                 310                 315                 320 


Thr Val Ala Arg Asn Gly Asp Asn Glu Ser Leu Gln Val Ala Ser Thr 
                325                 330                 335     


His Gln Gln Phe Leu Leu Asp Ile Arg Leu Met Leu Gln Thr Leu Gly 
            340                 345                 350         


Val Asp Ser Lys Val Val Lys Met Asp Glu Met Gly Tyr Arg Ser Leu 
        355                 360                 365             


Pro Asp Gly Lys Gly Gly Tyr Gln Asp Tyr Phe Cys Gln Ala Lys Tyr 
    370                 375                 380                 


Arg Leu Leu Ile Ser Ser Asn Gly Leu Phe Gln Leu Gly Glu Leu Gly 
385                 390                 395                 400 


Leu Lys Thr Asn Arg Leu Gln Trp Asn Leu Arg Glu Pro Gln Arg Glu 
                405                 410                 415     


Ala Ser Gln Phe Ile Arg Val Glu Lys Val Glu Leu Thr Cys Arg Tyr 
            420                 425                 430         


Asp Asp Thr Tyr Cys Phe Ser Glu Pro Lys Arg His Leu Gly Met Phe 
        435                 440                 445             


Asn Gly Ile Leu Thr Gly Gln Ser Gly Val Lys Val Ala Val Leu Asp 
    450                 455                 460                 


Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser 
465                 470                 475                 480 


Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr 
                485                 490                 495     


His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu 
            500                 505                 510         


Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala 
        515                 520                 525             


Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala 
    530                 535                 540                 


Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser 
545                 550                 555                 560 


Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly 
                565                 570                 575     


Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser 
            580                 585                 590         


Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln 
        595                 600                 605             


Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile 
    610                 615                 620                 


Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr 
625                 630                 635                 640 


Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
                645                 650                 655     


Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile 
            660                 665                 670         


Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu 
        675                 680                 685             


Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695                 700     


<210>  159
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Dhan_GLT1

<400>  159

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Ser 
            100                 105                 110         


Asp Thr Leu Val Arg Thr Ser Glu Gly Asp Lys Pro Val Ala Glu Val 
        115                 120                 125             


Ala Ile Gly Asp Tyr Leu Leu Asp Ala Glu Asp Lys Pro Val Leu Cys 
    130                 135                 140                 


Met Gly Ala Asn Pro Ser Gln Thr Gly Arg Met Lys Glu Ile Ala Tyr 
145                 150                 155                 160 


Gln Asp Phe Asp Ser Lys Lys Arg Val Ser Phe Lys Cys Thr Pro Asp 
                165                 170                 175     


His His Leu Glu Leu Thr Leu Thr Asp Ser Thr Pro Ser Leu Ser Gly 
            180                 185                 190         


Lys Ser Val Thr Trp Phe Ser Arg Cys Thr Gly Ala His Leu Ser Glu 
        195                 200                 205             


Glu Val Ser Glu Val Tyr Leu Asp Asn Met Val Ser Ile Phe Tyr Asn 
    210                 215                 220                 


Asp Leu Val Asp Ser Thr Asp Ser Ala Val Asp Lys Asp Ser Ile His 
225                 230                 235                 240 


Glu Ala Val Asp Leu Ala Leu Glu Asp His Tyr His Arg Gly Asn Ser 
                245                 250                 255     


Asp Gln Tyr Ser Ile His Leu Asn Glu Tyr Ile Ser Arg Ile Ala Asp 
            260                 265                 270         


Lys Glu Leu Gln Asn Glu Pro Glu Phe Ile Arg Glu Cys Ile His Asp 
        275                 280                 285             


Ala Ala Asn Arg Phe Val Ile Thr Ser Ser Gly Asn Arg Asn Ile Lys 
    290                 295                 300                 


Ser Glu Ser Phe Asp Asp Lys Leu Leu Leu Ser Arg Ser Arg Ser Ser 
305                 310                 315                 320 


Thr Ala Asp Ser Asp Ser Asp Tyr Val Ile Thr Asp Ala Ser Val His 
                325                 330                 335     


Ser His Ser Asn Asn Ser Ser Val Tyr Leu Ala Ser Pro Asp Ser Met 
            340                 345                 350         


Ile Pro Asp Gly Ala Ala Asn Arg Phe Glu Asn Ile Ala Ser Lys Leu 
        355                 360                 365             


Lys Glu Pro Val Cys Asn Cys Gly Gly Ile Arg Lys Ile Phe Arg Ser 
    370                 375                 380                 


Phe Gly Thr Thr Glu Asp Ala Glu Leu Ala Tyr Ser Leu Leu Leu Ser 
385                 390                 395                 400 


Glu His Tyr Tyr Arg Leu Asp Pro Arg Phe Val Thr Asp Gly Tyr Thr 
                405                 410                 415     


Phe Gln Ala Ser Val Glu Gln Tyr Glu Asn Met Cys Ser Gln Glu Val 
            420                 425                 430         


Gln Asn Met His Leu Lys Leu Tyr Arg Ser Pro Leu Lys Phe Val Glu 
        435                 440                 445             


Arg Glu His Asn Ser Ala Glu Leu Pro Val Asp Pro Tyr Phe Leu Gly 
    450                 455                 460                 


Leu Trp Leu Gly Asp Gly Asp Ser Ser Gly Thr Thr Ile Met Thr Thr 
465                 470                 475                 480 


Asp Arg Glu Ile Val Val Trp Leu Asn Ser Tyr Val Glu Arg Leu Asn 
                485                 490                 495     


Gln Asn Lys Pro Glu Gly Cys Phe Pro Leu Lys Leu Thr Glu Gln Leu 
            500                 505                 510         


Ile Tyr Gly Ala Gly His Thr Ser Lys Ser Gly His Thr Thr Lys Val 
        515                 520                 525             


Asp Val Arg Asn Tyr Lys Ile Ser Ser Gly Asp Ala Phe Val Arg Ser 
    530                 535                 540                 


Gly Thr Tyr Trp Asn Pro Ile Phe Asp Gly Leu Lys Lys Leu Gly Leu 
545                 550                 555                 560 


Leu Asn Asn Lys Ser Ala Gly Ile Pro Gln Glu Tyr Met Asn Ser Asp 
                565                 570                 575     


Glu Gln Asn Arg Leu Ser Val Ile Ala Gly Leu Met Asp Ser Asp Gly 
            580                 585                 590         


Cys Tyr Val Lys Ser His Asn Thr Tyr Arg Phe Thr Gln Leu Thr Glu 
        595                 600                 605             


Asp His Lys Lys Ile Val Tyr Asp Leu Lys Glu Leu Ala Leu Ser Cys 
    610                 615                 620                 


Gly Ile Asn Thr Thr Gly Val Glu Leu Ser Val Lys Pro Leu Gly Phe 
625                 630                 635                 640 


Asn Lys His Lys His Ser Thr Glu Tyr Val Val Tyr Leu Gly Asn Gly 
                645                 650                 655     


Ser Gln Lys Phe Gln Glu Leu Leu Leu Leu Pro Arg Lys Lys Met Glu 
            660                 665                 670         


Ile Ser Lys Lys His Val Ser Leu Asp Ala Arg Pro Phe Thr Val Ser 
        675                 680                 685             


Asp Val Glu Asp Gly Glu Phe Arg Ala Ile Glu Val Ser Gly Gly Val 
    690                 695                 700                 


Phe Gln Leu Ala Asn Arg Leu Val Val Ala Asn Ser Gly Val Lys Val 
705                 710                 715                 720 


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
                725                 730                 735     


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
            740                 745                 750         


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
        755                 760                 765             


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
    770                 775                 780                 


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
785                 790                 795                 800 


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
                805                 810                 815     


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
            820                 825                 830         


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
        835                 840                 845             


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
    850                 855                 860                 


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
865                 870                 875                 880 


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
                885                 890                 895     


Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
            900                 905                 910         


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
        915                 920                 925             


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
    930                 935                 940                 


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
945                 950                 955                 960 


Arg 
    


<210>  160
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Fsp-CcI3_RIR1

<400>  160

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Gln Pro Tyr 
            100                 105                 110         


Asp Ala Leu Val Ser Thr Pro Ser Gly Leu Val Pro Ile Gly Ala Leu 
        115                 120                 125             


Val Glu Thr Asp Ala Val Gly Met Lys Val Phe Asp Ala His Gly Leu 
    130                 135                 140                 


Thr Gln Val Ile Ala Thr Lys Ser Asn Gly Val Lys Asp Val Leu Arg 
145                 150                 155                 160 


Ile Trp Thr Arg Ala Gly His Ala Leu Asp Val Thr Ala Asp His Leu 
                165                 170                 175     


Val Trp Arg Ser Thr Ser Ala Gly Ala Gly Ala Phe Val Pro Ala Gly 
            180                 185                 190         


Ala Leu Arg Ala Gly Asp Thr Leu Glu Trp His Arg Thr Ile Ala Pro 
        195                 200                 205             


Gly Glu Gly Glu Ile Thr Ser Arg Glu Ile Ala Glu Ala Ala Leu Ala 
    210                 215                 220                 


Gly Arg Leu Gln Ala Asp Gly Phe Val Gly Arg Tyr Ala Gly Thr Asn 
225                 230                 235                 240 


Ala Ser Leu Thr Ile Glu Ala Met Thr Val Pro Thr Arg Leu Tyr Asp 
                245                 250                 255     


Ala Pro Leu Pro Val Val Ala Ala Tyr Leu Arg Ser Leu Phe Gln Ala 
            260                 265                 270         


Asp Gly Tyr Val Ser Arg Arg Glu Arg Ser Thr Leu Ile Gly Leu Asp 
        275                 280                 285             


Met Ile Ser Glu Gly Leu Ile Arg Gly Val Gln Gly Leu Leu Ala Arg 
    290                 295                 300                 


Phe Gly Ile Phe Ala Arg Val Arg Arg Glu Ala Asp Pro Arg Pro Asp 
305                 310                 315                 320 


Arg His Asp Leu Trp Ser Leu Gly Ile Gln Asn Ala Gly Asp Arg Arg 
                325                 330                 335     


Thr Phe Ala Asp Glu Ile Gly Phe Leu Asp Pro Val Lys Ala Ala Lys 
            340                 345                 350         


Leu Glu Ala Ser Phe Asp Gln Pro Gly Gln Ala Ala Lys Pro Val Lys 
        355                 360                 365             


Arg Leu Gln Ile Glu Arg Ile Glu Pro Arg Gly Pro Met Pro Val Tyr 
    370                 375                 380                 


Asp Ile Gln Thr Asp Ser Gly Glu Tyr Leu Ser Ala Gly Leu Arg Val 
385                 390                 395                 400 


His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
                405                 410                 415     


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
            420                 425                 430         


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
        435                 440                 445             


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
    450                 455                 460                 


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
                485                 490                 495     


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
            500                 505                 510         


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
        515                 520                 525             


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
    530                 535                 540                 


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
545                 550                 555                 560 


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
                565                 570                 575     


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
            580                 585                 590         


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
        595                 600                 605             


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
    610                 615                 620                 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
625                 630                 635                 640 


Val Asn Ala Glu Ala Ala Thr Arg 
                645             


<210>  161
<211>  800
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Gob_DnaE

<400>  161

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Val Ala 
            100                 105                 110         


Gly Thr Glu Val Thr Asp Ala Glu Thr Gly Ala Val Val Thr Val Gly 
        115                 120                 125             


Glu Leu Phe Glu Ser Arg Arg Ala Val Thr Val His Ala Leu Gly Ala 
    130                 135                 140                 


Asp Ser Lys Leu Arg Pro Arg Pro Val Thr Asp Val Val Trp Asn Gly 
145                 150                 155                 160 


Arg Lys Arg Val Tyr Arg Leu Thr Thr Glu Leu Gly Lys Ser Ile Thr 
                165                 170                 175     


Ala Thr Asp Asn His Pro Phe Arg Val Leu Asp Gly Trp Lys Asn Leu 
            180                 185                 190         


Gly Glu Leu Lys Pro Gly Asp Arg Ile Ala Ala Pro Arg Arg Leu Ala 
        195                 200                 205             


Val Pro Ser Ala Gly Thr Trp Pro Gln His Glu Ile Val Ala Leu Ala 
    210                 215                 220                 


Gly Leu Leu Ser Glu Gly Asn Thr Cys His Pro Thr Thr Leu Tyr Phe 
225                 230                 235                 240 


Tyr Gly Asn Asp Arg Val Leu Ile Asp Asp Phe Ala Arg Ala Ile Gly 
                245                 250                 255     


Gln Phe Pro Asp Thr Val Ala Lys Val Tyr Ala Arg Pro Asn Arg Arg 
            260                 265                 270         


Asn Leu Glu Val Arg Ala Asn Thr Gly Arg Asp Thr Arg Leu Lys Ser 
        275                 280                 285             


Arg Ala Glu Arg Asp Ala Ala Val Ala Leu Leu Ala Pro Pro Thr Arg 
    290                 295                 300                 


Ser Gly Ala Phe Val Trp Ala Gln Arg Leu Gly Ile Leu Gly Lys Thr 
305                 310                 315                 320 


Ala Thr Glu Lys Phe Val Pro His Asp Val Phe Arg Leu Cys Asp Ser 
                325                 330                 335     


Asp Leu Glu Leu Phe Leu Gly Arg Leu Trp Ala Gly Asp Gly Phe Ile 
            340                 345                 350         


Ala Asn Asp Thr Leu Lys Val Pro Phe Tyr Ala Thr Ser Ser Arg Arg 
        355                 360                 365             


Leu Ala Gln Asp Val Gln His Leu Leu Leu Arg Leu Gly Ile Val Gly 
    370                 375                 380                 


Arg Ile His Glu Lys Gln Phe Lys Tyr Lys Gly Gly Leu Lys Pro Gly 
385                 390                 395                 400 


Phe Thr Val His Leu Ile Gly Asp Gly Ala Ala Glu Ala Phe Leu Asp 
                405                 410                 415     


Arg Ile Ala Pro His Cys Leu Gly Arg Glu His Ala Val Thr Ile Leu 
            420                 425                 430         


Arg Glu His Val Ala Thr Thr Ala Arg Gly Leu Thr Ser Lys Asp Thr 
        435                 440                 445             


Val Pro Leu Glu Val Arg Ala Trp Val Asp Asp Gly Arg Arg Ala Arg 
    450                 455                 460                 


Gly Leu Thr Trp Asp Glu Leu Glu Gln Gln Ser Asp Val Ser Thr Gln 
465                 470                 475                 480 


Glu Phe Tyr Gly Thr Pro Ala Pro Gly Lys Lys Gly Phe Arg Arg Ala 
                485                 490                 495     


Thr Ile Ala Lys Leu Ala Ala Phe Phe Gly Ser Gln Arg Leu Ala Ala 
            500                 505                 510         


Val Ala Asp Ser Asp Val Phe Trp Asp Arg Val Val Ser Ile Glu Tyr 
        515                 520                 525             


Ala Gly Val Gln Asp Thr Tyr Asp Leu Thr Val Asp Glu Asp His Asn 
    530                 535                 540                 


Phe Val Ala Asn Gly Leu Ile Val His Asn Ser Gly Val Lys Val Ala 
545                 550                 555                 560 


Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly 
                565                 570                 575     


Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly 
            580                 585                 590         


His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile 
        595                 600                 605             


Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val 
    610                 615                 620                 


Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu 
625                 630                 635                 640 


Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly 
                645                 650                 655     


Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr 
            660                 665                 670         


Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly 
        675                 680                 685             


Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala 
    690                 695                 700                 


Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly 
705                 710                 715                 720 


Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly 
                725                 730                 735     


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
            740                 745                 750         


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
        755                 760                 765             


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
    770                 775                 780                 


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795                 800 


<210>  162
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Gob_Hyp

<400>  162

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Gln Pro Ala 
            100                 105                 110         


Gly Thr Gln Val Ala Lys Val Ile Lys Glu Gly Arg Trp Arg Glu Asp 
        115                 120                 125             


Ser Val Ile Glu Gln Val Pro Ile Glu Ser Leu Gln Pro Gly Asp Arg 
    130                 135                 140                 


Val Val Ser Phe Gly Asn Ala Lys Ile Tyr Arg Arg Gly Arg Ala Val 
145                 150                 155                 160 


Thr Gly Ile Thr Ser Arg Arg His Thr Gly Asn Leu His Arg Val Glu 
                165                 170                 175     


Val Gly Glu Phe Arg Thr Arg Ala Thr Pro Glu His Arg Phe Thr Val 
            180                 185                 190         


Arg Phe Asp Pro Ala Arg Pro Lys Ala Gly Leu Leu Tyr Leu Met Arg 
        195                 200                 205             


Arg Gly Asp Arg Trp Arg Val Gly Val Cys Gly Met Phe Asn Ser Arg 
    210                 215                 220                 


Gly Phe Gly Val Ser Val Arg Leu Ser Gln Glu Arg Gly Asp Ala Ala 
225                 230                 235                 240 


Trp Val Leu Gly Ala Phe Ala Thr Leu Thr Glu Ala Arg Ile Ala Glu 
                245                 250                 255     


Gln Val Val Ser Cys Arg Tyr Gly Ile Pro Thr Thr Val Trp Glu Thr 
            260                 265                 270         


Gly Arg Asn Pro Gly Ala Ser Trp Ala Gln Arg Asp Gln Ala Gly Ile 
        275                 280                 285             


Asp Ala Ile Tyr Gln Arg Leu Gly Val Asp Arg Ile Arg Ala Gly Val 
    290                 295                 300                 


Asp Arg Leu Leu Arg Asp His Gly Leu Ser Ala Gly Leu Pro Leu Leu 
305                 310                 315                 320 


Ala Ala Asn Glu Pro Gly Asn Phe Ser Cys Arg Gln Ser Arg Gln Val 
                325                 330                 335     


Ala Ala Cys Asn Leu Val Pro Gly Val Met Gln Val Pro Val Pro Thr 
            340                 345                 350         


Ala Gly Glu Arg Phe Glu Trp Arg Asp Leu Thr Ala Thr Ser Phe Glu 
        355                 360                 365             


Arg Val His Asp Leu Glu Val Trp Ser Met Asp Val Glu Arg Asp Lys 
    370                 375                 380                 


His Tyr Val Ala Asp Gly Ile Val Val His Asn Ser Gly Val Lys Val 
385                 390                 395                 400 


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
                405                 410                 415     


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
            420                 425                 430         


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
        435                 440                 445             


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
    450                 455                 460                 


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
465                 470                 475                 480 


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
                485                 490                 495     


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
            500                 505                 510         


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
        515                 520                 525             


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
    530                 535                 540                 


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
545                 550                 555                 560 


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
                565                 570                 575     


Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
            580                 585                 590         


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
        595                 600                 605             


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
    610                 615                 620                 


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
625                 630                 635                 640 


Arg 
    


<210>  163
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Gvi_RIR1-1

<400>  163

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Ala 
            100                 105                 110         


Gly Thr Leu Leu His Thr Glu Gln Gly Tyr Val Pro Val Glu Gln Val 
        115                 120                 125             


Val Ala Gly Val Gly Thr Arg Val Cys Thr His Gln Gly Phe Arg Asn 
    130                 135                 140                 


Ile Ser Glu Arg Phe Asp Asn Gly Glu Ala Glu Val Phe Arg Val Thr 
145                 150                 155                 160 


Thr Arg Lys Gly Tyr Ser Val Glu Val Thr Ala Asn His Lys Met Ala 
                165                 170                 175     


Arg Leu Asp Glu Asn Gly Asp Leu Leu Leu Asp Glu Leu Ser His Leu 
            180                 185                 190         


Gln Val Gly Asp Asn Leu Leu Leu Leu Leu Gly Ser Asn Pro Val Thr 
        195                 200                 205             


Glu Lys Val Arg Leu Gln Cys Ile Pro Ala Gly Tyr Arg Ser Ser Ile 
    210                 215                 220                 


Glu Ile Ala Gln Pro Pro Glu Leu Asp Glu Gln Leu Ala Tyr Leu Leu 
225                 230                 235                 240 


Gly Tyr Ala Tyr Gly Asp Gly Cys Val Gly Arg Gly Ala Thr Tyr Asn 
                245                 250                 255     


Tyr Leu Ser Leu Ala Val Ser His Thr Tyr Pro Asn Val Arg Asp Gln 
            260                 265                 270         


Leu Ala Ala Ile Ile Arg Glu Lys Phe Gly Leu Thr Thr Lys Ile Tyr 
        275                 280                 285             


Ser Gly Ser Gly Ala Val Trp Asn Leu Leu Val His Ser Ala Asn Leu 
    290                 295                 300                 


Leu Asp Trp Leu Lys Ala Asn Gly Leu Leu Lys Gln Lys Ala Ala Asp 
305                 310                 315                 320 


Leu Ala Met Pro Glu Ala Ile Leu Arg Ser Pro Ser Ser Val Val Gly 
                325                 330                 335     


Ala Phe Leu Ser Gly Tyr Phe Asp Ala Asp Gly Cys Val Arg Gly Gly 
            340                 345                 350         


Lys Gly Gly Tyr Gly Phe Asp Cys Thr Ser Lys Ala Phe Val Gly Ala 
        355                 360                 365             


Val Gln Leu Leu Leu Leu Ala Glu Gly Ile Val Ser Asn Leu His Thr 
    370                 375                 380                 


Thr Asp Arg Ser Arg Gln Gly Trp Arg Thr Ile Tyr Arg Leu Asn Val 
385                 390                 395                 400 


Cys Gly Thr Glu Phe Lys Arg Arg Phe Gln Thr Leu Cys Cys Arg Ser 
                405                 410                 415     


Ala Lys Val Val His Ser Pro Met Val Leu Gly Arg Asp Gly Thr Gly 
            420                 425                 430         


Gly Tyr Pro Pro Ala Leu Val Arg Gly Ala Ser Tyr Gln Arg Val Val 
        435                 440                 445             


Ala Val Gly Gly Lys His Leu Leu Tyr Thr Ala Leu Leu Lys Val Ile 
    450                 455                 460                 


Glu Lys Thr Arg Thr Ala Gly Lys Gln Ala Leu Ala Glu Ser Leu Cys 
465                 470                 475                 480 


Gln His Val Asn Tyr Phe Pro Asp Pro Ile Val Ala Ile Glu Ser Val 
                485                 490                 495     


Gly Thr Gln Arg Val Tyr Asp Ile Glu Val Glu Gly Met His Leu Leu 
            500                 505                 510         


Gly Asn Gly Ile Tyr Thr Ser Asn Ser Gly Val Lys Val Ala Val Leu 
        515                 520                 525             


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
    530                 535                 540                 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
545                 550                 555                 560 


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
                565                 570                 575     


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
            580                 585                 590         


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
        595                 600                 605             


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
    610                 615                 620                 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
625                 630                 635                 640 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
                645                 650                 655     


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
            660                 665                 670         


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
        675                 680                 685             


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
    690                 695                 700                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
705                 710                 715                 720 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                725                 730                 735     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            740                 745                 750         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760                 765     


<210>  164
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hhal_DnaB-1

<400>  164

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Tyr 
            100                 105                 110         


Asp Ala Glu Ile Val Gln Ala Asp Gly Gly Val Lys Thr Ile Glu Gln 
        115                 120                 125             


Ile Val Arg Glu Arg Arg Ala His Leu Ala Thr Val Gly Ala Asp Trp 
    130                 135                 140                 


Arg Leu Thr Trp Thr Glu Pro Cys Asp Tyr Val Asp Asp Gly His Lys 
145                 150                 155                 160 


Pro Val Phe Glu Val Thr Thr Arg Leu Gly Arg Arg Ile Glu Thr Thr 
                165                 170                 175     


Leu Thr His Pro Phe Leu Thr Val His Gly Trp Gln Arg Leu Glu Asp 
            180                 185                 190         


Leu Ala Glu Gly Asp Ala Ile Gly Val Pro Arg Gln Leu Pro Val Phe 
        195                 200                 205             


Gly Gln Glu Pro Ile Arg Asp Cys Glu Val Arg Leu Leu Gly His Leu 
    210                 215                 220                 


Ile Gly Asp Gly Gly Leu Thr Gly Ser Pro Pro Arg Leu Thr Ser Gly 
225                 230                 235                 240 


Gln Glu Ala Met Thr Ala Asp Phe Leu Glu Ala Val Asp Ala Phe Gly 
                245                 250                 255     


Gly Val Glu Ala Lys Pro Ile Arg Ala Ser Arg Arg Thr Gln Ser Trp 
            260                 265                 270         


Val Val Val Gly Ala Ala Gln Ala Arg Ala Ala Ala Arg Ser Ser Phe 
        275                 280                 285             


Ala Ser Leu Val Asp Ala Leu Ile Arg Arg Ser Pro Leu Thr Gly Arg 
    290                 295                 300                 


Ala Ile Ala Arg Asn Leu Gly Val Ala Pro Ala Thr Leu Thr Tyr Trp 
305                 310                 315                 320 


Arg Gln Gly Val Asn Val Pro Asp Ala Ala Met Val Gly Leu Leu Ala 
                325                 330                 335     


Gly Glu Leu Gly Val Asp Val Gly Glu Leu Arg Pro Glu Pro Val Ala 
            340                 345                 350         


Arg Arg Asn Asp Arg Asn Pro Leu Gln Ala Trp Leu Asp Arg Leu Gly 
        355                 360                 365             


Leu Ala Gly Lys Ser Ala His Glu Lys Thr Val Pro Asp Cys Val Phe 
    370                 375                 380                 


Arg Leu Pro Arg Glu Gln Leu Ala Arg Phe Leu Asn Arg Leu Phe Ser 
385                 390                 395                 400 


Ser Asp Gly Trp Val Thr His Leu Ala Ser Gly Gln Gly Gln Ile Gly 
                405                 410                 415     


Tyr Thr Thr Val Ser Glu Ala Leu Ala Arg Gln Ile Gln His Leu Leu 
            420                 425                 430         


Leu Arg Phe Gly Val Leu Ala Lys Leu Arg His Arg Ser Val Arg Tyr 
        435                 440                 445             


Gln Asp Gly Arg Arg Pro Ala Trp Gln Leu Asp Ile Thr His Ala Glu 
    450                 455                 460                 


Ser Ile Leu Thr Phe Ala Glu Gln Ile Gly Ile Leu Gly Lys Glu Gln 
465                 470                 475                 480 


Arg Leu Ala Ser Val Ala Ala Ser Val Arg Gly Arg Arg Arg Gln Ser 
                485                 490                 495     


His Thr Asp His Ile Pro Cys Glu Ile Trp Gln Phe Ile Asp Arg Ala 
            500                 505                 510         


Arg Gly Glu Trp Thr Trp Ala Glu Leu Ala Arg Arg Ala Gly Val Ala 
        515                 520                 525             


Ser Ser Asn Ile His Ala Tyr Arg Arg Gly Met Ser Arg Gln Arg Leu 
    530                 535                 540                 


Ala Ala Phe Ala Asp Ala Leu Gly Ser Arg Glu Leu Arg Gln Leu Ala 
545                 550                 555                 560 


Ser Ser Asp Leu Tyr Trp Asp Arg Ile Ala Ser Ile Arg Pro Leu Gly 
                565                 570                 575     


His Lys Gln Val Tyr Asp Leu Thr Ile Pro Glu Thr His Asn Phe Ile 
            580                 585                 590         


Ala Asn Asp Val Cys Val His Asn Ser Gly Val Lys Val Ala Val Leu 
        595                 600                 605             


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
    610                 615                 620                 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
625                 630                 635                 640 


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
                645                 650                 655     


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
            660                 665                 670         


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
        675                 680                 685             


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
    690                 695                 700                 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
705                 710                 715                 720 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
                725                 730                 735     


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
            740                 745                 750         


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
        755                 760                 765             


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
    770                 775                 780                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
785                 790                 795                 800 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                805                 810                 815     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            820                 825                 830         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840                 845     


<210>  165
<211>  831
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hma_CDC21

<400>  165

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val His Gly 
            100                 105                 110         


Asp Thr Arg Val Thr Leu Ala Asp Gly His Glu Arg Pro Ile Arg Glu 
        115                 120                 125             


Val Val Glu Ser Asn Leu Asp Asp Pro Lys Pro Val Asp Asp Gly Val 
    130                 135                 140                 


Trp Asp Thr Val Asp Phe Asp Val Pro Ser Leu Gln Ser Asp Gly Thr 
145                 150                 155                 160 


Val Ala Thr Gln Asn Ala Thr Lys Val Trp Lys Arg Lys Ala Pro Glu 
                165                 170                 175     


Thr Leu Tyr Arg Ile Arg Thr Ala Thr Gly Arg Glu Leu Asp Val Thr 
            180                 185                 190         


Pro Ser His Pro Leu Phe Val Gln Ser Asp Gly Arg Phe Gln Ala Arg 
        195                 200                 205             


Lys Ala Glu Glu Leu Glu Ser Gly Thr His Val Ala Val Pro Arg Lys 
    210                 215                 220                 


Val Ser Thr Asn Ala Cys Asn Glu Leu Asp Val Thr Phe Arg Gln Ser 
225                 230                 235                 240 


Gln Ala His Asn Arg Ile Asp Leu Asp Leu Pro Pro Gln Trp Thr Pro 
                245                 250                 255     


Glu Leu Ala Arg Leu Ile Gly Tyr Ile Val Ala Glu Gly Tyr Val Glu 
            260                 265                 270         


Gln Arg Pro Asp Asn Thr Gly Tyr Val Ser Ile Thr Asn Asn Asp Arg 
        275                 280                 285             


Glu Val Leu Asp Asp Ala Lys Ser Val Leu Glu Thr Leu Asn Leu Asn 
    290                 295                 300                 


Val Thr Glu Arg Ser Ser His Glu Gly Lys Thr Ala Arg Glu Leu Leu 
305                 310                 315                 320 


Cys Ser Ala Gly Glu Phe Val Ser Phe Leu Ala Ser Leu Asp Glu Thr 
                325                 330                 335     


Leu Leu Gln Ser Ser Ala Glu Arg Arg Val Pro Gln Asp Ile Met Arg 
            340                 345                 350         


Ala Ser Asp Asn Val Val Thr Gly Phe Ile Arg Gly Tyr Ile Glu Gly 
        355                 360                 365             


Glu Gly His Val Ser Thr Ser Gln Arg Glu Ile Thr Val Ala Ser Met 
    370                 375                 380                 


Ser Lys Pro Leu Leu Glu Asp Val Arg Thr Leu Leu Val Thr Gln Gly 
385                 390                 395                 400 


Ile Thr Ala Gln Leu Gln Pro Arg Asn Asn Gly Ser Tyr Arg Leu Arg 
                405                 410                 415     


Ile Ser Gly Gln Ser Phe His Asp Tyr Ala Glu Gln Ile Gly Phe Ile 
            420                 425                 430         


Thr Ala Arg Lys Thr Glu Ala Cys Arg Gln Phe Glu Gly Thr His Gly 
        435                 440                 445             


Asn Thr Asn Leu Asp Ile Val Pro Asn Leu Gly Pro Glu Leu Arg Arg 
    450                 455                 460                 


Ile Arg Glu Ala Leu Gly Leu Thr Gln Ser Glu Cys Gly Leu Pro Arg 
465                 470                 475                 480 


Ser Thr Tyr Gln His Tyr Glu Arg Gly Arg Arg Asn Pro Ser Arg Asp 
                485                 490                 495     


Ser Leu Glu Ser Val Leu Asp Ala Phe Glu Thr Arg Leu Ala Glu Met 
            500                 505                 510         


Asn Asn Asp Thr Pro Ile Ser Asp Thr Ala Arg Ser Asp Gly Gly Gly 
        515                 520                 525             


Thr Gly Ser Leu Arg Gln Asp Leu Asn Gly Leu Ala Ala Leu Val Glu 
    530                 535                 540                 


Gly Asp Ile Ala Trp Asp Arg Ile Glu Ser Ile Glu Pro Ile Glu His 
545                 550                 555                 560 


Asp Glu Lys Trp Val Tyr Asp Leu Glu Ile Glu Gly Thr His Asn Tyr 
                565                 570                 575     


Leu Thr Asn Gly Val Val Ser His Asn Ser Gly Val Lys Val Ala Val 
            580                 585                 590         


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
        595                 600                 605             


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
    610                 615                 620                 


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
625                 630                 635                 640 


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
                645                 650                 655     


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            660                 665                 670         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        675                 680                 685             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    690                 695                 700                 


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
705                 710                 715                 720 


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
                725                 730                 735     


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
            740                 745                 750         


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
        755                 760                 765             


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
    770                 775                 780                 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
785                 790                 795                 800 


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
                805                 810                 815     


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            820                 825                 830     


<210>  166
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hma_TopA

<400>  166

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Ala 
            100                 105                 110         


Asp Ser Asp Val Leu Val Arg Ser Glu Asn Gly Asp Ile Glu Arg Gln 
        115                 120                 125             


Thr Val Asp Ser Leu Phe Ser Asp Gly Gln Val Val Leu Ala Asp Gly 
    130                 135                 140                 


Asp Thr Asp Ile Ala Val Ser Lys Glu Thr Pro Thr Val Leu Ser Leu 
145                 150                 155                 160 


Asp Glu Ala Thr Glu Arg Val Ser Glu Gln Glu Ser Thr Leu Val Ser 
                165                 170                 175     


Glu Arg Pro Leu Arg Asp Asp Glu Ser Val Arg Thr Ile Glu Thr Ser 
            180                 185                 190         


Arg Gly Ala Val Thr Val Thr Asp Asp His Pro Met Tyr Ile Arg Gln 
        195                 200                 205             


Asp Gly Glu Val Thr Val Arg Pro Ala Ser Asp Ile Glu Ala Gly Thr 
    210                 215                 220                 


Asp Leu Val Ala Ala Arg Arg Pro Pro Asp Thr Met Val Glu Pro Ser 
225                 230                 235                 240 


Asp Glu Thr Val Leu Ser Trp Glu Thr Phe Ala Ala Asp Cys Asp Lys 
                245                 250                 255     


His Ser Lys Leu Tyr Gly Val Asp Cys Gly Thr Glu Leu Ala Ala Gln 
            260                 265                 270         


Arg Ala Ala Arg Asp Glu Ser Gln Thr Ala Phe Ala Glu Arg Tyr Gly 
        275                 280                 285             


Ser Tyr Gly Ser Ala Val Gly Lys Tyr Glu Arg Gly Glu Lys Asp Val 
    290                 295                 300                 


Pro Val Trp Leu Leu Gly Glu Leu Asp Ile Arg Pro Asp Arg Ile His 
305                 310                 315                 320 


Gly Leu Asn Tyr Glu Thr Ser Phe Glu Asn Pro Phe Pro Leu Glu Trp 
                325                 330                 335     


Ser Pro Glu Leu Ala Gln Val Ile Gly Cys Leu Leu Gly Asp Gly Ser 
            340                 345                 350         


Ile His Arg Asn Asp Asp Glu Asn Val Val Asp Val Arg Tyr His Asn 
        355                 360                 365             


Thr Asp Glu Ala Leu Ile Glu Arg Phe Ala Arg Asp Ile Glu Arg Leu 
    370                 375                 380                 


Phe Asp Ile Glu Pro Thr Val Thr Asp Arg Pro Gly Arg Glu Ser His 
385                 390                 395                 400 


His Lys Arg Lys Tyr Gln Val Asp Val Pro Ser Ala Val Gly Arg Val 
                405                 410                 415     


Leu Val Cys Val Leu Glu Ala Val Thr Glu Asn Gly Thr Pro Gly Leu 
            420                 425                 430         


Pro Asp Ala Val Arg Pro Ala Phe Val Gly Ala Leu Phe Asp Asp Glu 
        435                 440                 445             


Gly His Ile Ser Arg Glu Gly Lys Ala Phe Ile Ser Asn Thr Asp His 
    450                 455                 460                 


Thr Leu Leu Thr Gly Val Gly Glu Met Leu Ala Glu Met Gly Ile Glu 
465                 470                 475                 480 


Thr Lys Leu Ala Pro Asp Gln His Lys Leu His Ile Arg Gly Arg Arg 
                485                 490                 495     


Asn Leu Glu Gln Phe Leu Asp Arg Ile Pro Ile Ala Ser Asp Glu Lys 
            500                 505                 510         


Phe Tyr Arg Gly Leu Asp Ala Leu Asp Ala Tyr Asp Val Thr Thr Arg 
        515                 520                 525             


Lys Ala Glu Leu Leu Glu Ala Ile Arg Gln Glu Pro Lys Thr Ser Ala 
    530                 535                 540                 


Ala Leu Ala Gln Thr Leu Gly Val Thr Arg Gly Ser Val Asn Lys Tyr 
545                 550                 555                 560 


Leu Arg Glu Leu Arg Glu Ser Gly His Ile Glu Lys Gln Ile Glu Gly 
                565                 570                 575     


Ser Asn Arg Ser Leu Asp Glu Asn Arg Thr Val Gln Tyr Val Ala Ala 
            580                 585                 590         


Asp Phe Glu Gly Ser Val Tyr Ala Thr Leu Arg Gly Glu Pro Ser Ser 
        595                 600                 605             


Val Thr Val Glu Asp Val Glu Arg Arg Glu Tyr Asp Gly Pro Val Tyr 
    610                 615                 620                 


Asp Leu Thr Val Ser Glu Asn Ala Pro Asn Phe Ala Val Asn Gly Gly 
625                 630                 635                 640 


Ala Val Val His Asn Ser Ser Gly Val Lys Val Ala Val Leu Asp Thr 
                645                 650                 655     


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
            660                 665                 670         


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
        675                 680                 685             


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
    690                 695                 700                 


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
705                 710                 715                 720 


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
                725                 730                 735     


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
            740                 745                 750         


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
        755                 760                 765             


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
    770                 775                 780                 


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
785                 790                 795                 800 


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
                805                 810                 815     


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
            820                 825                 830         


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
        835                 840                 845             


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
    850                 855                 860                 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
865                 870                 875                 880 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                885                 890         


<210>  167
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Hsa-NRC1_CDC21

<400>  167

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Arg Gly 
            100                 105                 110         


Asp Thr Thr Val Ala Leu Ala Asp Gly Ser Glu Arg Glu Ile Arg Asp 
        115                 120                 125             


Leu Val Glu Ala Asn Leu Asp Asp Pro Arg Pro Val Asp Asp Gly Val 
    130                 135                 140                 


Trp Asp Gly Val Asp Val Ala Val Pro Ser Leu Ala Ala Asp Gly Arg 
145                 150                 155                 160 


Leu Val Gln Arg Arg Ala Thr Lys Val Trp Lys Arg Glu Ala Pro Glu 
                165                 170                 175     


Thr Met Tyr Arg Val Arg Thr Ala Ala Gly His Arg Leu Thr Val Thr 
            180                 185                 190         


Pro Ser His Pro Leu Phe Val Ala Gly Ser His Gly Pro Asp Ala Val 
        195                 200                 205             


Arg Thr Glu Asp Leu Glu Val Gly Gln Leu Val Gly Val Ala Pro Asp 
    210                 215                 220                 


Gly Asp Gly Ser Gly Gln Val Ala Pro Asp Gly Gly Val Ile Arg Asp 
225                 230                 235                 240 


Ala Gln Pro Ala Pro Val Gly Asp Ala Glu Thr Val Ala Trp Ser Ala 
                245                 250                 255     


Ile Glu Ser Ile Thr Glu Val Glu Pro Asp Glu Glu Trp Val Tyr Asp 
            260                 265                 270         


Leu Glu Val Glu Gly Thr His Ser Tyr Leu Thr Asp Gly Val Val Ser 
        275                 280                 285             


His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
    290                 295                 300                 


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
305                 310                 315                 320 


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
                325                 330                 335     


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
            340                 345                 350         


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
        355                 360                 365             


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
    370                 375                 380                 


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
385                 390                 395                 400 


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
                405                 410                 415     


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
            420                 425                 430         


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
        435                 440                 445             


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
    450                 455                 460                 


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
465                 470                 475                 480 


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
                485                 490                 495     


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
            500                 505                 510         


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
        515                 520                 525             


Val Asn Ala Glu Ala Ala Thr Arg 
    530                 535     


<210>  168
<211>  791
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hvo_PolB

<400>  168

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Val Thr Gly 
            100                 105                 110         


Asp Arg Pro Val Val Val Arg Asp Pro Gly Gly Thr Val Arg Ile Leu 
        115                 120                 125             


Pro Ile Glu Asp Leu Phe Ala Arg Gly Thr Thr Glu Ser Glu Val Leu 
    130                 135                 140                 


Ile Ala Ala Asp Gly Asp Val Val Ala Ser Ala Thr Pro Gly Lys Thr 
145                 150                 155                 160 


Arg Arg Ala Leu Asp Gly Trp Asp Ala Leu Ser Val Asn Glu Asp Gly 
                165                 170                 175     


Glu Ala Glu Trp Gln Pro Ile Ala Gln Ala Ile Arg His Asn Thr Asp 
            180                 185                 190         


Lys Pro Val Val Asn Leu Gln His Lys Phe Gly Glu Ser Thr Thr Thr 
        195                 200                 205             


Arg Asp His Ser Tyr Val Val Pro Gly Glu Asp Gly Leu Thr Thr Val 
    210                 215                 220                 


Ser Pro Asp Asp Val Ala Glu Pro Tyr Arg Val Ser Gly Val Pro Asp 
225                 230                 235                 240 


Val Glu Pro Val Glu Gln Val Asp Val Tyr Glu Val Leu Arg Gly Tyr 
                245                 250                 255     


Glu Arg Glu Tyr Glu Asp Gly Arg Ser Val Gly Ser Asp Asn Ser Ile 
            260                 265                 270         


Thr Lys Arg Lys Gln Ile His Ala Asp Asp Glu Tyr Val Trp Phe Gly 
        275                 280                 285             


His Glu His His Arg Asp Val Asp Ser Thr Val Lys Val Lys Arg Phe 
    290                 295                 300                 


Val Asp Ile Asp Ser Glu Asp Gly Ala Ala Leu Ile Arg Leu Leu Gly 
305                 310                 315                 320 


Ala Tyr Val Pro Glu Gly Ser Ala Ser Thr Gly Glu Thr Ala Thr Ser 
                325                 330                 335     


Lys Phe Gly Ala Ser Leu Ala Glu Ser Asp Arg Glu Trp Leu Ala Gln 
            340                 345                 350         


Leu Gln Arg Asp Tyr Ser Arg Leu Phe Glu Asn Thr Thr Ala Gly Ile 
        355                 360                 365             


Ile Thr Ser Asp Arg Arg Ala Glu Arg Thr Val Glu Tyr Gln Thr Asp 
    370                 375                 380                 


Thr Gly Gly Ala Ser Val Thr Tyr Asn Asp Glu Thr Leu Lys Leu Gln 
385                 390                 395                 400 


Met Met Asn Glu Leu Ala Ala Val Phe Phe Arg Glu Phe Ala Gly Gln 
                405                 410                 415     


Thr Ser Arg Gly Lys Arg Ile Pro Ser Phe Val Phe His Leu Pro Glu 
            420                 425                 430         


Glu Lys Gln Asp Leu Phe Leu Thr Leu Leu Val Glu Gly Asp Gly Ser 
        435                 440                 445             


Arg Glu Phe Pro Arg Tyr Thr Glu Ala Tyr Ala Gln Arg Asn Phe Asp 
    450                 455                 460                 


Phe Glu Thr Thr Ser Arg Glu Leu Ala Ala Gly Leu Ser Met Leu Leu 
465                 470                 475                 480 


Thr Gln Arg Gly Gln Lys His Ser Leu Lys Tyr Arg Asp Ser Lys Asp 
                485                 490                 495     


Ser Tyr Thr Ile Arg Thr Cys Ser Thr Tyr Arg Glu Gly Arg Asp Pro 
            500                 505                 510         


Val Leu Thr Glu Ala Asp His Asp Gly Tyr Val Tyr Asp Leu Ser Val 
        515                 520                 525             


Glu Glu Asn Glu Asn Phe Val Asp Gly Val Gly Gly Ile Val Leu His 
    530                 535                 540                 


Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
545                 550                 555                 560 


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
                565                 570                 575     


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
            580                 585                 590         


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
        595                 600                 605             


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
    610                 615                 620                 


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
625                 630                 635                 640 


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
                645                 650                 655     


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
            660                 665                 670         


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
        675                 680                 685             


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
    690                 695                 700                 


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
705                 710                 715                 720 


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
                725                 730                 735     


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
            740                 745                 750         


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
        755                 760                 765             


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
    770                 775                 780                 


Asn Ala Glu Ala Ala Thr Arg 
785                 790     


<210>  169
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hwa_GyrB

<400>  169

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ser Gly 
            100                 105                 110         


Asp Thr Glu Ile Ala Leu Ala Ser Gly Asp Ser Ile Thr Phe Glu Ser 
        115                 120                 125             


Leu Val Asp Ala Tyr Glu Arg Gly Glu Thr His Tyr Cys Tyr Thr Ile 
    130                 135                 140                 


Gly Asp Asp Gly Arg Ile Arg Ile Glu Glu Ile Met Asn Pro Arg Val 
145                 150                 155                 160 


Thr Gln Glu Asp Ala Ala Leu Leu Ala Val Thr Leu Asp Asn Gly Glu 
                165                 170                 175     


Val Ile Arg Cys Thr Pro Asp His Glu Phe Met Leu Arg Asp Gly Asn 
            180                 185                 190         


Tyr Cys Glu Ala Gln Asn Leu Thr Asp Gly Gln Ser Leu Met Pro Leu 
        195                 200                 205             


Tyr Arg Thr Thr Thr Glu Met Thr Glu Thr Thr Glu Thr Thr Glu Thr 
    210                 215                 220                 


Thr Gly Thr Ala Glu Met Val Lys Gln Pro Phe Ala Gln Asn Asn Trp 
225                 230                 235                 240 


Glu Ser Val Ser Gln Leu Ala Asn Arg Tyr Asn Arg Arg His Thr Thr 
                245                 250                 255     


Thr Asp His Ile Val Glu Thr Gln Gln Ile Gln Ser Gln Gln Gln Ser 
            260                 265                 270         


Gln Ile Glu Thr Val Gln Ile Ser Glu Arg Ala Asp Val His Asn His 
        275                 280                 285             


Thr Val Ile Ser Val Glu Ser Leu Thr Glu Thr Ala Asp Val Tyr Asp 
    290                 295                 300                 


Leu Glu Val Pro Val Thr His Asn Phe Ala Leu Ala Ser Gly Val Phe 
305                 310                 315                 320 


Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser 
                325                 330                 335     


Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly 
            340                 345                 350         


Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly 
        355                 360                 365             


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro 
    370                 375                 380                 


Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly 
385                 390                 395                 400 


Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly 
                405                 410                 415     


Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr 
            420                 425                 430         


Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val 
        435                 440                 445             


Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg 
    450                 455                 460                 


Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg 
465                 470                 475                 480 


Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly 
                485                 490                 495     


Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn 
            500                 505                 510         


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
        515                 520                 525             


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
    530                 535                 540                 


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
545                 550                 555                 560 


Leu Val Asn Ala Glu Ala Ala Thr Arg 
                565                 


<210>  170
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hwa_MCM-1

<400>  170

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ser Gly 
            100                 105                 110         


Glu Thr Asp Ile Ala Leu Val Glu Gly Lys Thr Ala Thr Ile Gly Glu 
        115                 120                 125             


Leu Val Glu Ser Ala Leu Thr Asp Pro Lys Pro Val Asp Asp Gly Val 
    130                 135                 140                 


Trp Asp Thr Ala Asp Phe Thr Val Thr Ser Ala Ile Glu Thr Gly Glu 
145                 150                 155                 160 


Leu Ile Glu Arg Asp Val Thr Arg Val Trp Lys Arg Gln Ser Pro Glu 
                165                 170                 175     


Thr Met Arg Gln Ile Gln Ile Ala Gly Gly Arg Ser Val Thr Val Thr 
            180                 185                 190         


Pro Ser His Pro Val Phe Val Glu His Asn Gly Ser Tyr Thr Ala Arg 
        195                 200                 205             


Arg Ala Asp Ser Leu Ser Ala Gly Glu Ser Val Ala Ile Ala Asp Asp 
    210                 215                 220                 


Val Ala Asp Ser His Pro Ile Ser Val Asp Asn Thr Ala Asn Thr Leu 
225                 230                 235                 240 


Asn Pro Arg Ser Met Ser Thr Pro Gly Ile Thr Thr Asp Gly Gly Leu 
                245                 250                 255     


Tyr Arg Thr Gly Ser Asp Gly Gly Ile Val His Ala Glu Val Gly Lys 
            260                 265                 270         


Glu Asp Val Thr Asp Cys Leu Thr Thr Asp Arg Ile Thr Ala Val Lys 
        275                 280                 285             


Thr Val Thr Pro Thr Ala Glu Trp Val Tyr Asp Leu Glu Val Glu Gly 
    290                 295                 300                 


Thr His Ala Tyr Leu Thr Asn Gly Val Leu Ser His Asn Ser Gly Val 
305                 310                 315                 320 


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
                325                 330                 335     


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
            340                 345                 350         


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
        355                 360                 365             


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
    370                 375                 380                 


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
385                 390                 395                 400 


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
                405                 410                 415     


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
            420                 425                 430         


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
        435                 440                 445             


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
    450                 455                 460                 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
465                 470                 475                 480 


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
                485                 490                 495     


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            500                 505                 510         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        515                 520                 525             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    530                 535                 540                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
545                 550                 555                 560 


Ala Thr Arg 
            


<210>  171
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hwa_MCM-4

<400>  171

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Tyr His Pro 
            100                 105                 110         


Arg Ser Glu Val Leu Leu Ala Asp Gly Gln Arg Ile Asp Ile Gly Thr 
        115                 120                 125             


Phe Val Asp Ser Arg Ile Glu Lys Asn Asn Ala Asn Val Ile Asp Gly 
    130                 135                 140                 


Ile Asn Cys Glu Ile Leu Pro Val Asp Asp Ile Asp Val Tyr Thr Val 
145                 150                 155                 160 


Asp Thr Asp Thr Gly Ser Ala Ser Thr Val Ser Ile Asp Arg Val Ser 
                165                 170                 175     


Arg His Pro Ala Pro Ser Glu Phe Ile Arg Val Lys Phe Ser Asn Gly 
            180                 185                 190         


Arg Ser Val Leu Val Thr Pro Glu His Pro Met Phe Ile Asp Asp Gly 
        195                 200                 205             


Ser Glu Thr Lys Thr Val Gln Ala Asn Ala Leu Ser Gly Gly Glu Phe 
    210                 215                 220                 


Val Pro Ala Pro His His Leu Pro Gly Val Asn Thr Asp Ala Ser Ser 
225                 230                 235                 240 


Val Ser Asp Asp Ile Asn Asp Val Ser Thr Ile Arg Thr His Val Arg 
                245                 250                 255     


Ser Arg Ala Arg Ala Lys Ala Glu Val Glu Val Arg Ala Thr Asp Gly 
            260                 265                 270         


Glu Phe Lys Leu Ile Asp Ala Ala Gln Thr Leu Gly Ile Ile Thr Ala 
        275                 280                 285             


Val Gly Lys Val Ser Val Asp Ala Pro Glu Arg Gly Ile Ile Val Asp 
    290                 295                 300                 


Met Asp Arg Thr Val Asp Ser Ser Lys Asp Ser Ile Asn Asn Val Leu 
305                 310                 315                 320 


Gly Ser Val Ile Pro Ser Asn Asp Asn Asp Ser Ile Thr Arg Val Gln 
                325                 330                 335     


Asp Thr Gly Ser Thr Gly Asn Gln Trp Arg Trp Ser Val Asn Thr Phe 
            340                 345                 350         


Ile Glu Arg Met Ile Glu Ile Ala Pro Ala Val Thr Ala Asp Arg Pro 
        355                 360                 365             


Asn Arg Arg Val Pro Asp Ala Val Leu Gly Gly Ser Glu Ala Val Val 
    370                 375                 380                 


Gln Gln Phe Leu Thr Gly Val Ile Ile Ala Ala Gly Arg Ile Leu Asp 
385                 390                 395                 400 


Glu Thr Ile Arg Ile Tyr Ala Ser Ser Asn Glu Leu Ala Cys Asp Tyr 
                405                 410                 415     


Ala Asp Ala Phe Leu Arg Leu Gly Ile Thr Ala Ser Val Glu Asp Gly 
            420                 425                 430         


Pro Ala Glu Ile Ala Ala Gln Thr Val Ile Lys Cys Asp Ser Asp Tyr 
        435                 440                 445             


Glu Arg Ala Cys Gly Met Phe Asp Ile Ser Ser Ser Arg Thr Thr Pro 
    450                 455                 460                 


Ser Asp Thr Ser Ser Gln Asn Asn Gln Ser Ser Val Thr Ala Gln Asn 
465                 470                 475                 480 


Glu Asp Thr His Gln Thr Thr Ser His Glu Ile Leu Pro Ser Gly Ile 
                485                 490                 495     


Ala Asp Glu Leu Gln Ser Ile Arg Gln Leu Leu Asn Ile Pro Ala Ser 
            500                 505                 510         


Glu Gln Leu Ala Ser Ile Thr Ala Gly Asp Asp Gly Ile Ala Leu Ser 
        515                 520                 525             


Ile Ala Arg Ala Glu Ile Asn Leu Leu Arg Asp His Ile Glu Thr Leu 
    530                 535                 540                 


Arg Met Asp Thr Glu Asn Val Ser Ile Gly Arg Asp Asp Cys Val Thr 
545                 550                 555                 560 


Pro Thr Ile Ser Ser Ser Ser Lys Tyr Lys Tyr Ala Lys Asn Ser Ile 
                565                 570                 575     


Thr Ser Asp Glu Asn Leu Gln Leu Phe Gly Gln Ser Gln Ala Gln Leu 
            580                 585                 590         


Ser Glu Arg Thr Lys Thr Thr Glu Ser Ser Ser Ile Ser Ala Ser Thr 
        595                 600                 605             


Asp Leu Val Ser Ile Pro Ala Asn Ile Ser Glu Asn Arg Leu Val Ala 
    610                 615                 620                 


Ala Thr Gln Arg Leu Asp Glu Val Glu Thr Arg Cys Asn Arg Arg Tyr 
625                 630                 635                 640 


His Arg Val Ile Ala Val Asp Thr Val Ser Asn Ala Gly Pro His Ala 
                645                 650                 655     


Cys Glu Trp Val Tyr Asp Ile Thr Val Glu Pro Thr Asn Thr Phe Ile 
            660                 665                 670         


Ser Ser Gly Val Val Leu His Asn Ser Gly Val Lys Val Ala Val Leu 
        675                 680                 685             


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
    690                 695                 700                 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
705                 710                 715                 720 


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
                725                 730                 735     


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
            740                 745                 750         


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
        755                 760                 765             


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
    770                 775                 780                 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
785                 790                 795                 800 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
                805                 810                 815     


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
            820                 825                 830         


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
        835                 840                 845             


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
    850                 855                 860                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
865                 870                 875                 880 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                885                 890                 895     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            900                 905                 910         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        915                 920                 925     


<210>  172
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hwa_PolB-2

<400>  172

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Thr Pro 
            100                 105                 110         


Asp Thr Asn Val Leu Thr Pro Asn Gly Val Arg Asn Ile Arg Asp Leu 
        115                 120                 125             


Thr Val Gly Asp Ser Val Tyr Ser Leu Asn Pro Glu Thr Met Gln Met 
    130                 135                 140                 


Glu Ile Lys Pro Val Thr Gln Thr His Glu Tyr Pro Asp Tyr Gln Gly 
145                 150                 155                 160 


Asp Leu Ile Asp Ile Gln Thr Asn Glu Ile Asp Phe Arg Val Thr Pro 
                165                 170                 175     


Asn His Arg Met Leu Val Glu Ala Thr Gly Thr Asp Thr Thr Ser Thr 
            180                 185                 190         


Asn Asp Tyr Asp Phe Ile Glu Ala Gly Asn Leu Asp Ile Ser Ser Arg 
        195                 200                 205             


Tyr Glu Leu Pro His Gly Trp Ser Val Asp His Thr Asp Ser Leu Gly 
    210                 215                 220                 


Ala Tyr Ile Asp Leu Ile Thr Leu Leu Arg Glu Gln Ser Asp Thr Tyr 
225                 230                 235                 240 


Asn Val Leu Ser Asp Gly Gly Met Thr Thr Ala Ala Thr Ala Asp Ile 
                245                 250                 255     


Asn His Asn Asn Val Thr Arg Arg Val Asp Ser Asp Thr Phe Val Ser 
            260                 265                 270         


Leu Ile Gly Trp Tyr Val Ala Thr Gly Arg Val Ser Arg Thr Gln Asn 
        275                 280                 285             


Gly Ser Asp Arg Val Tyr Leu Gln Leu Ser Gln Thr Asn Thr Lys Ala 
    290                 295                 300                 


Arg Thr Gln Leu Thr Met Leu Leu Asp Glu Leu Gly Val Asp Trp Gln 
305                 310                 315                 320 


Ala Asp Asn Glu Lys Ile His Phe Val Ser His Val Trp Thr Glu Leu 
                325                 330                 335     


Phe Asp Thr Thr Cys Gly Arg Thr Glu Lys Asn Lys His Ile Pro Glu 
            340                 345                 350         


Leu Ile Phe Asp Ala Ser Ala Ser Gln Lys Arg Ala Phe Phe Asp Ala 
        355                 360                 365             


Ile Ile Asn Gly Ser Gly Val Lys Asn Asp Asp Ser Tyr Gln Tyr His 
    370                 375                 380                 


Thr Ser Ser Glu Asp Leu Arg Asp Asp Ile Leu Arg Leu Cys Val His 
385                 390                 395                 400 


Ile Gly Ile Val Ala Arg Tyr Asp Tyr Ile Asn Asp Glu Ser Trp Arg 
                405                 410                 415     


Ile Glu Cys Thr Glu Thr Ala Asn Pro Asp Phe Thr Leu Thr His Ser 
            420                 425                 430         


Gly Arg Gln Ser Thr Ala Glu Asp Gly Val Tyr Cys Val Thr Val Ala 
        435                 440                 445             


Asp Asn Gln Thr Leu Leu Ala Gly Arg Asn Gly Thr Phe Gln Trp Thr 
    450                 455                 460                 


Gly Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
465                 470                 475                 480 


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
                485                 490                 495     


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
            500                 505                 510         


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
        515                 520                 525             


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
    530                 535                 540                 


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
545                 550                 555                 560 


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
                565                 570                 575     


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
            580                 585                 590         


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
        595                 600                 605             


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
    610                 615                 620                 


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
625                 630                 635                 640 


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
                645                 650                 655     


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            660                 665                 670         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        675                 680                 685             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    690                 695                 700                 


Val Asn Ala Glu Ala Ala Thr Arg 
705                 710         


<210>  173
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hwa_Pol-II-1

<400>  173

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe His Pro 
            100                 105                 110         


Glu Thr Lys Ile Trp Phe Arg Asp Thr Asp Asn Glu Trp His His Glu 
        115                 120                 125             


Thr Ile Gln Thr Phe Val Glu Asp Arg Leu Asp Asp Pro Glu Ile Asp 
    130                 135                 140                 


Ala Val Gly Thr Leu Val Gln Glu Val Asp Asp Asn Thr Asp Arg Glu 
145                 150                 155                 160 


Ile Ser Val Pro Ser Ile Asp Asp Asn Gly Asn Glu Arg Leu Gln Ser 
                165                 170                 175     


Val Thr Ala Val Ser Lys His Arg Ala Pro Asn His Leu Val Gln Ile 
            180                 185                 190         


Glu Thr Ile Ser Gly Arg Glu Ile Thr Ile Thr Pro Asp His Glu Met 
        195                 200                 205             


His Ile Phe Glu Gln Gly Asn Leu Val Ser Lys Gln Ala Ser Lys Ile 
    210                 215                 220                 


Thr Ser Gly Glu Tyr Ala Val Ile Pro Lys Arg Leu Gln Thr Ile Ser 
225                 230                 235                 240 


Pro Ser Ser His Thr Pro Gln His Asp Leu Leu Arg Glu Phe Leu Thr 
                245                 250                 255     


Arg Asp Glu Leu Thr Ala Asp Arg Leu Ile Ile His Thr Ser Asp Pro 
            260                 265                 270         


Val Arg Leu Cys Asn Arg Val Phe Pro Glu Glu Val Thr Ser Cys Lys 
        275                 280                 285             


Asp Ala Val Glu Ile Met Gln Asn Thr Ala Cys His Leu Asp Lys Asn 
    290                 295                 300                 


Lys Glu Thr Leu Ile Gly Trp Leu Gly Glu Gly Arg Ile Pro Val Ala 
305                 310                 315                 320 


Leu Leu Arg Gly Phe Val Glu Thr Asp Glu Ala Leu Leu Met Ser Ile 
                325                 330                 335     


Pro Asp Asp Val Gln Ile Gly Leu Arg Gly Glu Lys Val Arg Ile Asp 
            340                 345                 350         


Arg His Ile Gly Phe Thr Glu Glu Leu Thr Ser Leu Leu Gly Tyr Tyr 
        355                 360                 365             


Ala Ala Ala Gly Ile Val His Thr Gln Thr Asn Pro Ile Ser Tyr Glu 
    370                 375                 380                 


Ser Ala Gln Gln Glu Gln Ser Arg Ile Thr Phe Tyr Asn Ile Asp Thr 
385                 390                 395                 400 


Gln Thr Gln Thr Asp Leu Leu Asn Ala Leu Asn Ser Val Phe Glu Ile 
                405                 410                 415     


Glu Pro Ile Gln Tyr Asn Leu Asp Gly Glu Ile Leu Gly Val Pro Gly 
            420                 425                 430         


Glu Leu Ile Arg Arg Val Phe Asp Thr Val Phe Asp Val Gly Thr Gln 
        435                 440                 445             


Pro Ser His Lys Arg Ile Pro Gln Ala Leu Phe Asp Ala Ser Glu Ser 
    450                 455                 460                 


His Ile Thr Ser Tyr Leu Arg Cys Phe Phe Ser Thr His Asp Ser Leu 
465                 470                 475                 480 


Thr Thr Asp Thr Arg Asp Ile Ser Ala Thr Thr Val Ser Arg Glu Phe 
                485                 490                 495     


Lys Glu Asp Ile Ile Ala Ala Leu Arg Arg Leu Gly Ile Thr Ala Glu 
            500                 505                 510         


Val Thr Thr Gln Gln Ser Arg Ser Val Pro Glu Val Leu Pro Asp Trp 
        515                 520                 525             


Tyr Ala Ile Asp Asp Ile Thr His His Asp Ala Asp Asn Ser Leu Asn 
    530                 535                 540                 


Leu Thr Arg Ser Tyr Val Ile Ser Ile Ala Ser Ser Asp Ala Val Thr 
545                 550                 555                 560 


Leu Gln Arg Asp Arg Gln Ala Gln Glu Gln Ile Lys Tyr Asp Ala Gln 
                565                 570                 575     


Gly Leu Ile Ala Asn Asn Asn Ala Ile His Gln Ser Arg Gln Val Thr 
            580                 585                 590         


Asp Gly Gly Arg Lys Asp Tyr Ile Thr Glu Pro Ile Thr Asp Ile Glu 
        595                 600                 605             


Tyr Val Asp Ala Asp Ile Asp Tyr Thr Tyr Cys Leu Thr Val Ser Glu 
    610                 615                 620                 


Thr His Ser Leu Ile Val Asn Asp Leu Ser Gln Lys Gln Ser Gly Val 
625                 630                 635                 640 


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
                645                 650                 655     


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
            660                 665                 670         


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
        675                 680                 685             


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
    690                 695                 700                 


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
705                 710                 715                 720 


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
                725                 730                 735     


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
            740                 745                 750         


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
        755                 760                 765             


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
    770                 775                 780                 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
785                 790                 795                 800 


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
                805                 810                 815     


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            820                 825                 830         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        835                 840                 845             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    850                 855                 860                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
865                 870                 875                 880 


Ala Thr Arg 
            


<210>  174
<211>  898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hwa_Pol-II-2

<400>  174

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Val Ala Ala 
            100                 105                 110         


Asp Ser Arg Leu Val Ala Val Ser Pro Asp Asp Lys Ile Val Phe Thr 
        115                 120                 125             


Thr Ile Glu Asp Phe Trp Lys Lys Leu Asn Thr Pro Ile Glu Arg Asn 
    130                 135                 140                 


Gly Lys Phe Arg Lys Arg Thr Cys Val Ser Glu Gly Trp Gln Thr Tyr 
145                 150                 155                 160 


Ala Phe Asp Glu Asn His Glu Ala Ser Leu Arg Pro Ile Glu Lys Ala 
                165                 170                 175     


Ile Arg Tyr Thr Ala Asp Glu Ser Glu Gln Leu Arg Arg Ile Thr Thr 
            180                 185                 190         


Gln Leu Gly Arg Ser Leu Asp Ile Thr Asp Glu His Ser Leu Phe Arg 
        195                 200                 205             


Tyr Asp Asp Gly Ile Glu Glu Val Ala Gly Asp Asp Leu Thr Ala Gly 
    210                 215                 220                 


Asp Ile Ile Val Ala Pro Arg Thr Leu Asp Val Glu Val Thr Gln Thr 
225                 230                 235                 240 


Thr Leu Asp Leu Ser Glu Tyr Ile His Asp Asn Glu Arg Cys Pro Ser 
                245                 250                 255     


Glu Gln Thr Gly Ser Gly Glu Leu Asn Leu Ala Ser Lys Ser Ala Ile 
            260                 265                 270         


Ser Asp Ser Arg Asn Lys Glu Thr Pro Gly Val Thr His Asn Ile Leu 
        275                 280                 285             


Pro Gln Arg Ser Lys Phe Thr Asp Glu Met Thr Thr Leu Ser Pro Thr 
    290                 295                 300                 


Ala Val Gly Gly Leu Glu Ser Glu Gln Asn Glu Thr Leu Arg Val Gly 
305                 310                 315                 320 


Glu Ser Thr Gly Ala Ile Glu Arg Tyr Ile Asn Val Asp Asp Ser Phe 
                325                 330                 335     


Gly Trp Leu Leu Gly Gln Phe Ile Ala Gln Arg Ser Ile Ser Thr Asp 
            340                 345                 350         


Ala Leu Thr Met Thr Val His Thr Ala Ala Glu Lys His Ala Glu Arg 
        355                 360                 365             


Ile Val Ala Thr Ser Asp Ser Val Phe Gly Ile Lys Pro Thr Val Asn 
    370                 375                 380                 


Ser Ile Glu Arg Gly Tyr Glu Ile Val Phe Pro Ser Val Phe Asp Thr 
385                 390                 395                 400 


Ile Val Ser Gly Leu Thr Ala Lys Glu Gln Ser Glu Pro Glu Gln Asp 
                405                 410                 415     


Val Asp His Thr His Thr Asp Glu Ile Gly Ile Pro Glu Cys Ile Leu 
            420                 425                 430         


His Ala Pro Asp Asp Ile Val Leu Ser Phe Leu Gln Gly Phe Ile Leu 
        435                 440                 445             


Ala Glu Asn Ala Gln Arg Lys Gly Asn Ala Ala Ser Glu Ala Ser Glu 
    450                 455                 460                 


Met Val Ser Glu Ser Glu Thr Thr Val Thr Leu Glu Thr Pro Ser Val 
465                 470                 475                 480 


Gly Val Lys Asp Gly Leu Val Phe Leu Cys His Arg Leu Gly Val Ile 
                485                 490                 495     


Thr Asp Ile Ser Glu Lys Ser Gly Glu Glu Tyr Ser Val His Phe Glu 
            500                 505                 510         


Glu Ser Arg Tyr Thr Val Ser Ile Ala Thr Glu Gly Lys Thr Asn Pro 
        515                 520                 525             


Leu Asp Gln Ile Leu Asn Gly Glu Arg Pro Thr Met Pro Glu Gly Val 
    530                 535                 540                 


Ser Val Pro Val Pro Asp Ala Leu Leu Thr Ile His Glu Ser Ile Ala 
545                 550                 555                 560 


Asn Ser Pro His Ile Asp Gln Val Ile Pro Asp Thr Val Val Gln Gln 
                565                 570                 575     


Glu Thr Val Ser Leu Glu Thr Leu Gln Ser Leu Leu Thr Gly Leu Ser 
            580                 585                 590         


Thr Val Asp Leu Pro Ala Gln Leu Glu Ala Lys Arg Asp Glu Leu Thr 
        595                 600                 605             


Leu Leu Thr Glu Gly Asp Leu Ser Tyr Leu Arg Val Glu Ser Val Glu 
    610                 615                 620                 


Cys Val Asp Tyr Asp Gly Tyr Leu Tyr Asp Leu Gln Val Gly Gly Glu 
625                 630                 635                 640 


Pro Val Phe Thr Ala Asn Trp Leu Tyr Ala His Asn Ser Gly Val Lys 
                645                 650                 655     


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
            660                 665                 670         


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
        675                 680                 685             


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
    690                 695                 700                 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
705                 710                 715                 720 


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
                725                 730                 735     


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
            740                 745                 750         


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
        755                 760                 765             


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
    770                 775                 780                 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
785                 790                 795                 800 


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
                805                 810                 815     


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
            820                 825                 830         


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
        835                 840                 845             


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
    850                 855                 860                 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
865                 870                 875                 880 


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
                885                 890                 895     


Thr Arg 
        


<210>  175
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hwa_RIR1-1

<400>  175

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Ala 
            100                 105                 110         


Asp Ser Thr Val Met Leu Lys Glu Lys Gly Met Val Ser Val Ser Glu 
        115                 120                 125             


Val Glu Thr Gly Asp Gln Ile Ala Gln Arg Ser Asp Thr Gly Phe Gln 
    130                 135                 140                 


Tyr Lys Pro Val Glu Glu Thr His Ala Tyr Glu Asn Ala Glu Thr Leu 
145                 150                 155                 160 


Thr Val Thr Leu Thr Asn Gly Cys Ser Ile Arg Gly Thr Pro Asn His 
                165                 170                 175     


Arg Leu Met Val Asp Asp Glu Trp Thr Arg Ile Asp Glu Ile Gln Pro 
            180                 185                 190         


Asp Gln Glu Val His Tyr Thr Leu Gly Trp Leu Arg Glu Thr Asn Gln 
        195                 200                 205             


Ser Pro Pro Lys Leu His Ser Gln Ser His Thr Thr Val Asn Gln Thr 
    210                 215                 220                 


Ala Asp Ser Ile Ser Pro Asp Ser Ser Glu Pro Ile Glu Leu Ser Glu 
225                 230                 235                 240 


Ser Glu Asn Ala Asp Thr Gly Asn Arg His Asn Ser Ala Val Ala Val 
                245                 250                 255     


Lys Gln Ser Arg Thr Gln Thr Gln Leu Ile Ser Asp Glu Val Val Ser 
            260                 265                 270         


Arg Pro Glu His Thr Arg Arg Pro Asp Gln Leu Ser Glu Glu Leu Ala 
        275                 280                 285             


Glu Leu Leu Gly Leu Trp Ile Asp Thr Gly Leu Trp His Gln Ser Gly 
    290                 295                 300                 


Val Gln Phe Asn Val Glu Arg Glu Asn Ile Ala Glu Tyr Ile Asp Gln 
305                 310                 315                 320 


Leu Ser Gln Gln Leu Phe Asp Thr Pro Ala Ala Ile Ser Asp Thr Asp 
                325                 330                 335     


Gly Thr Tyr Thr Val Asp Ile Thr Asp His Lys Leu Lys Glu Trp Trp 
            340                 345                 350         


Lys Ala Asn Phe Gly Gly Lys Pro Asp Gly Thr Gln Ser Ser Tyr Val 
        355                 360                 365             


Pro Gln Met Ile Lys Glu Ala Pro Thr Asn Val Ile Glu Ala Phe Leu 
    370                 375                 380                 


Arg Gly Cys Phe Thr Ala Glu Gly Gly Leu Arg Lys Asp Met Arg Pro 
385                 390                 395                 400 


Arg Leu Cys Thr Ser Ser Glu Asp Ser Ile Asp Asp Ile Ala Val Leu 
                405                 410                 415     


Met Met Gly Leu Gly Tyr Pro Val Glu Lys Ser Val Ile Arg Asn Ala 
            420                 425                 430         


Asp Gly Glu Pro Tyr Tyr Ser Val Met Pro Ala Thr Asp Asp Gly Leu 
        435                 440                 445             


Ser Ala Phe Leu His Asp Val Gly Phe Ile Asp Glu Arg Arg Glu Ile 
    450                 455                 460                 


Gly Leu Ser Asn Ile Glu Ser Ser Asp Ser Arg Ala Leu Asn Asn Thr 
465                 470                 475                 480 


His Lys Ile Glu Val Glu Ser Ile Val Glu Ser Pro Pro Ala Thr Val 
                485                 490                 495     


Tyr Asp Ile Thr Val Ala Asp Asn His Glu Tyr Val Thr Asp Gly Ile 
            500                 505                 510         


Ile Ser His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        515                 520                 525             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    530                 535                 540                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
545                 550                 555                 560 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                565                 570                 575     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            580                 585                 590         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        595                 600                 605             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    610                 615                 620                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
625                 630                 635                 640 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                645                 650                 655     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            660                 665                 670         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        675                 680                 685             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    690                 695                 700                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
705                 710                 715                 720 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                725                 730                 735     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            740                 745                 750         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760         


<210>  176
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hwa_RIR1-2

<400>  176

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Glu Glu 
            100                 105                 110         


Asn Ser Leu Val Ser Thr Asp Glu Gly Leu Arg Pro Ile Lys Asp Leu 
        115                 120                 125             


Asp Asn Thr Thr Ala Glu Phe Glu Gln Trp Asp Glu Ile Asp Val Gly 
    130                 135                 140                 


Val Thr Thr Asp Gly Gly Thr Lys Thr Ala Thr Ala Val Tyr Asp Asn 
145                 150                 155                 160 


Gly Phe Ala Asn Val Arg Gln Ile Gln Thr Glu Ser Gly Phe Asn Ile 
                165                 170                 175     


Ala Ala Thr Pro Asn His Arg Phe Arg Thr Leu Ser Ser Asp Gly Thr 
            180                 185                 190         


Tyr Thr Trp Lys Glu Ala Gly Lys Phe Glu Ser Gly Asp Arg Val Ile 
        195                 200                 205             


Leu Gln Arg Asn Thr Phe Asp Ala Gly Ser Arg Val Ser Leu Glu Ala 
    210                 215                 220                 


Asn Glu Arg Ala Asp Asp Ala Gln Asp Thr Thr Glu Gly Pro Glu Leu 
225                 230                 235                 240 


Pro Gly Arg Met Thr Ser Glu Leu Ala Glu Phe Leu Gly Tyr Phe Met 
                245                 250                 255     


Gly Ser Gly Tyr Ile Ser Asp Glu Thr His Ala Ser Val Asp Leu Val 
            260                 265                 270         


Val Asp Ser Asp Ala Thr Glu Leu Asn Ser Tyr Leu Ser Asn Leu Gly 
        275                 280                 285             


Glu Gln Leu Phe Arg Ile Thr Pro Ala Val Glu Ser Gln Glu Met Ser 
    290                 295                 300                 


Gln Val Leu Ser Phe Arg Asp Cys His Leu Ser Arg Tyr Phe Glu Asp 
305                 310                 315                 320 


Asn Gly Trp Lys Lys Thr Asp Thr Gly His Asn Gly Asp Ala Ser Ala 
                325                 330                 335     


Ala Phe Val Pro Glu Gln Ile Leu Glu Gly Asp Glu Gln Val Val Asn 
            340                 345                 350         


Gly Phe Leu Arg Gly Val Phe Glu Ala Ile Gly Thr Val Ser Glu Lys 
        355                 360                 365             


Ile Glu Ile Leu Thr Thr Ser Thr Thr Leu Ala Asp Gln Leu Gln Ser 
    370                 375                 380                 


Leu Leu Leu Ser Leu Gly His Val Phe Thr Arg Asp Ser Thr Lys Leu 
385                 390                 395                 400 


Val Glu Thr Asn Asn Tyr His Asp Asp Gln Leu Arg Gln Arg Leu Cys 
                405                 410                 415     


Gly Ala Thr Arg Arg Glu Asp Glu Arg Phe Met Asn Glu Ile Gly Ser 
            420                 425                 430         


Leu Ile Glu Pro Asp Glu Leu Asn Leu Ser Thr Arg Ala Asp Lys Asn 
        435                 440                 445             


Asp Thr Tyr Pro Ser Ser Val Ile Asp His Val Gln Thr Leu Asp Gly 
    450                 455                 460                 


Tyr Asp Ser Val Ser Glu Ser Leu Lys Ser Arg Ile Asn Gln Ser Gln 
465                 470                 475                 480 


Val Asp Gly Thr Val Ser Arg Lys Leu Ile Lys Asp Ile Glu Ala Glu 
                485                 490                 495     


Thr Ala Glu Thr Val Ser Ile Ala Asp His Glu Leu Thr Gly Phe Tyr 
            500                 505                 510         


Ala Ala Thr Val Glu Ser Val Thr Glu Asp Thr Ala Tyr Thr Lys Asp 
        515                 520                 525             


Ile Ser Val Pro Ser Asn Asn Thr Tyr Ile Ala Asp Gly Phe Val Thr 
    530                 535                 540                 


His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
545                 550                 555                 560 


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
                565                 570                 575     


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
            580                 585                 590         


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
        595                 600                 605             


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
    610                 615                 620                 


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
625                 630                 635                 640 


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
                645                 650                 655     


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
            660                 665                 670         


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
        675                 680                 685             


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
    690                 695                 700                 


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
705                 710                 715                 720 


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
                725                 730                 735     


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            740                 745                 750         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        755                 760                 765             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    770                 775                 780                 


Val Asn Ala Glu Ala Ala Thr Arg 
785                 790         


<210>  177
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hwa_rPol_App

<400>  177

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Ile Glu Ala 
            100                 105                 110         


Asp Glu Ser Ile Val Ile Arg Arg Asp Gly Glu Thr Glu Leu Thr Glu 
        115                 120                 125             


Ile Gly Ser Phe Val Asp Thr Ile Leu Ala Ala Asp Asn Gln Glu Thr 
    130                 135                 140                 


Arg Ile Thr Asp Gly His Glu Ile Ala Leu Ala Pro Asn Gly Leu Glu 
145                 150                 155                 160 


Val Pro Ser Leu Asp Thr Asp Glu Gln Ile Arg Trp Lys His Ile Glu 
                165                 170                 175     


Ala Val Ser Arg His Ala Ser Pro Asp Glu Ile Leu Leu Ile Glu Leu 
            180                 185                 190         


Glu Ser Gly Arg Ser Ile Arg Ala Thr Lys Ala His Ser Phe Val Thr 
        195                 200                 205             


Arg Arg Asp Gly Asp Val Leu Pro Val Ala Gly Glu Thr Leu Val Val 
    210                 215                 220                 


Gly Asp Val Leu Pro Thr Val Gly Ser Tyr Asp His Ala Ser Gly Ser 
225                 230                 235                 240 


Ile Ser Val Pro Leu Gln Ser Gln Ser Val Ala Ala Asp Gly Gly Thr 
                245                 250                 255     


Val Glu Pro Asn Thr Asn Ile Thr Ala Asn Ala Glu Arg Asp Ser Ala 
            260                 265                 270         


Ser Ile Thr Ser Ala Gly Ile Ile Gly Ser Ala Thr Trp Glu Arg Ile 
        275                 280                 285             


Ser Ser Ile Glu Thr Val Ala Pro Glu Tyr Glu Tyr Val Tyr Asp Leu 
    290                 295                 300                 


Ser Val Ser Gly Leu Glu Thr Phe Thr Thr Gly Glu Gly Val Val Thr 
305                 310                 315                 320 


His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
                325                 330                 335     


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
            340                 345                 350         


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
        355                 360                 365             


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
    370                 375                 380                 


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
385                 390                 395                 400 


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
                405                 410                 415     


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
            420                 425                 430         


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
        435                 440                 445             


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
    450                 455                 460                 


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
465                 470                 475                 480 


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
                485                 490                 495     


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
            500                 505                 510         


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
        515                 520                 525             


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
    530                 535                 540                 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
545                 550                 555                 560 


Val Asn Ala Glu Ala Ala Thr Arg 
                565             


<210>  178
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Kra_DnaB

<400>  178

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Ala 
            100                 105                 110         


Gly Thr Arg Val Leu Arg Ala Asp Thr Gly Ala Glu Thr Thr Met Gly 
        115                 120                 125             


Glu Leu Phe Ala Leu Gln Ala Arg Asp Val Pro Val Trp Ser Leu Asp 
    130                 135                 140                 


Glu Ser Leu Arg Tyr Val Arg Arg His Leu Thr Arg Val Phe Pro Thr 
145                 150                 155                 160 


Gly Val Lys Pro Val Phe Arg Leu Arg Thr Ala Ser Gly Lys Thr Val 
                165                 170                 175     


Arg Ala Thr Ala Asn His Pro Phe Leu Thr Tyr Asp Gly Trp Lys Pro 
            180                 185                 190         


Leu Gly Glu Leu Ser Val Ala Asp Arg Leu Ala Val Pro Arg His Val 
        195                 200                 205             


Pro Ala Pro Glu Arg Val Ala Ser Trp Thr Asp Asp Gln Val Leu Leu 
    210                 215                 220                 


Leu Gly His Leu Ile Gly Asp Gly Ser Phe Val Lys Arg Gln Pro Leu 
225                 230                 235                 240 


Arg Tyr Ala Ser Val Asp Glu Ala Asn Leu Ser Ala Val Thr Glu Ala 
                245                 250                 255     


Ala Ala Asn Ala Phe Ser Ile Val Ala Val Arg Asp Glu Tyr Ala Ala 
            260                 265                 270         


Ala Arg Cys Thr Thr Leu Arg Leu Pro Ala Pro Tyr Arg Leu Thr His 
        275                 280                 285             


Gly Arg Arg Asn Pro Leu Ala Ala Trp Leu Asp Glu Leu Gly Leu Phe 
    290                 295                 300                 


Gly Leu Arg Ser Tyr Glu Lys Phe Val Pro Gln Glu Val Phe His Leu 
305                 310                 315                 320 


Pro Lys Arg Gln Ile Ala Leu Phe Leu Arg His Leu Trp Ala Thr Asp 
                325                 330                 335     


Gly Ser Val Thr Leu Thr Arg Gln Ser Arg Gly Gly Arg Ile Tyr Tyr 
            340                 345                 350         


Ala Ser Thr Ser Leu Gln Leu Ile Gln Asp Val Ser Arg Leu Leu Leu 
        355                 360                 365             


Arg Phe Gly Ile Ser Thr Arg Val Arg Thr Thr Thr Pro Lys Gly Asp 
    370                 375                 380                 


His Arg Pro Gly Tyr Thr Leu Asp Val Ser Gly Val Asp Asp Gln Arg 
385                 390                 395                 400 


Arg Phe Leu Gln Glu Ile Gly Val His Gly Ala Arg Gly Ala Thr Ala 
                405                 410                 415     


Asp Arg Leu Leu Glu Val Ile Arg Asp Val Ser Ala Asn Thr Asn Val 
            420                 425                 430         


Asp Thr Val Pro Arg Gln Val Trp Asp Asp Val Arg Arg Leu Leu Val 
        435                 440                 445             


Glu Lys Glu Met Thr His Arg Glu Phe Ala Ala Ala Met Gly Thr Ser 
    450                 455                 460                 


Phe Gly Gly Ser Ser Leu Trp Lys His Ala Pro Ser Arg Glu Arg Leu 
465                 470                 475                 480 


Gly Arg Val Ala Gln Val Leu Asp Ser Ala Glu Leu Asp Val Leu Ala 
                485                 490                 495     


Val Asn Asp Val Leu Trp Asp Glu Val Val Ala Ile Glu Pro Asp Gly 
            500                 505                 510         


Glu Glu Gln Val Tyr Asp Ala Thr Val Leu Gly Gly His Asn Phe Val 
        515                 520                 525             


Ala Asp Gly Ile Ala Val His Asn Ser Gly Val Lys Val Ala Val Leu 
    530                 535                 540                 


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
545                 550                 555                 560 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
                565                 570                 575     


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
            580                 585                 590         


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
        595                 600                 605             


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
    610                 615                 620                 


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
625                 630                 635                 640 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
                645                 650                 655     


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
            660                 665                 670         


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
        675                 680                 685             


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
    690                 695                 700                 


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
705                 710                 715                 720 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
                725                 730                 735     


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
            740                 745                 750         


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
        755                 760                 765             


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780         


<210>  179
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mca_RIR1

<400>  179

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Ala 
            100                 105                 110         


Asp Thr Trp Val Met Thr Ala Ser Gly Ala Arg Gln Val Arg Asp Leu 
        115                 120                 125             


Ile Asp Arg Pro Phe Glu Ala Val Val Asp Gly Glu Cys His Pro Thr 
    130                 135                 140                 


Glu Ser Arg Gly Phe Phe Phe Thr Gly Asp Lys Pro Val Leu Arg Leu 
145                 150                 155                 160 


Ser Thr Ala Glu Gly His Thr Leu Arg Leu Thr Ala Asn His Pro Val 
                165                 170                 175     


Leu Arg Val Ser Lys Met Thr Arg Gln Leu Arg Glu Thr Glu Trp Val 
            180                 185                 190         


Lys Ala Gly Glu Leu Arg Pro His Asp Lys Ile Val Leu His Asp His 
        195                 200                 205             


Arg Ala Leu Pro Ser Trp Asp Gly Ala His Thr Glu Ala Glu Gly Tyr 
    210                 215                 220                 


Leu Ile Gly Leu Leu Ile Gly Gly Gly Thr Leu Thr Arg Asp Lys Ala 
225                 230                 235                 240 


Ile Leu Ser Ile Trp Asp Ala Ala Ala Pro Lys Val Ala Asn Gly Gly 
                245                 250                 255     


Gly Ser Val Pro Ala Ala Gly Val Ala Gly Val Met Arg Ala Ala Glu 
            260                 265                 270         


Leu Ala Ala Arg Thr Leu Pro His Arg Thr Asp Phe Asn Gly Trp Gln 
        275                 280                 285             


Thr Thr Met Glu Gly Arg Gly Glu Tyr His Met Ala Thr Gly Ala Leu 
    290                 295                 300                 


His Thr Leu Ala Leu Glu Leu Gly Leu Thr Pro Gly Asp Lys Arg Leu 
305                 310                 315                 320 


Thr Ala Pro Leu Glu Thr Thr Ser Ser Ala Phe His Arg Gly Leu Leu 
                325                 330                 335     


Arg Gly Met Phe Asp Ala Asp Gly Ser Val Gln Gly Ser Gln Arg Lys 
            340                 345                 350         


Gly Val Ser Ile Arg Leu Pro Gln Thr Asp Leu Gly Asn Leu Gln Thr 
        355                 360                 365             


Val Gln Arg Met Leu Leu Arg Leu Gly Val Ala Ser Thr Ile His Gln 
    370                 375                 380                 


Asn Arg Arg Pro Gly Gly Thr Lys Val Leu Pro Asp Gly Glu Gly Gly 
385                 390                 395                 400 


Ala Lys Gly His Ser Cys Gln Ala Ala His Glu Leu Ile Ile Ser Gly 
                405                 410                 415     


Glu Asn Val Val Arg Tyr Ala Glu Arg Ile Gly Phe Ala Asp Ser Asp 
            420                 425                 430         


Lys Met Asp Arg Leu Thr Ala Leu Leu Gln Arg Tyr Arg His Thr Arg 
        435                 440                 445             


His Ala Glu Arg Phe Ile Ala Thr Val Gln Ser Leu Glu Asp Asp Gly 
    450                 455                 460                 


Met Glu Ala Val Tyr Asp Val Thr Val Ala Asp Val His Ala Phe Asp 
465                 470                 475                 480 


Ala Asn Gly Leu Tyr Val His Asn Ser Gly Val Lys Val Ala Val Leu 
                485                 490                 495     


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
            500                 505                 510         


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
        515                 520                 525             


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
    530                 535                 540                 


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
545                 550                 555                 560 


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
                565                 570                 575     


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
            580                 585                 590         


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
        595                 600                 605             


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
    610                 615                 620                 


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
625                 630                 635                 640 


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
                645                 650                 655     


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
            660                 665                 670         


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
        675                 680                 685             


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
    690                 695                 700                 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
705                 710                 715                 720 


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730                 


<210>  180
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Memar_Pol-II

<400>  180

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Gly 
            100                 105                 110         


Asp Thr Glu Ile Thr Val Ser Asp Gly Arg Arg Trp Met Ser Leu Pro 
        115                 120                 125             


Ile Arg Gln Phe Val Thr Glu Asn Phe Asp Ile Ser Lys Pro Gly Leu 
    130                 135                 140                 


Asp His Val Gly Thr Phe Tyr Ser Asp Pro Arg Gln Pro Phe Tyr Val 
145                 150                 155                 160 


Arg Ser Ile Asp Ser Gln Gly Lys Thr Ser Leu Lys Arg Val Thr Ser 
                165                 170                 175     


Val Ser Val His Arg Ala Pro Ala His Leu Val Arg Phe Ala Thr Arg 
            180                 185                 190         


Arg Gly Arg Val Leu Thr Val Thr Pro Asp His Ala Met Leu Val Trp 
        195                 200                 205             


Asp Thr Asp Tyr Leu Arg Lys Ile Lys Ala Leu Glu Val Ala Val Gly 
    210                 215                 220                 


Asp Arg Val Pro Val Glu Glu Gly Gly Leu Val Val Ala Asp Glu Val 
225                 230                 235                 240 


Val Ser Arg Glu Thr Val Gln Ala Leu Asp Asp Arg Val Tyr Cys Leu 
                245                 250                 255     


Thr Val Ala Glu Asn His Thr Leu Val Ala Asn Gly Ile Phe Cys Gly 
            260                 265                 270         


Gln Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
        275                 280                 285             


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
    290                 295                 300                 


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
305                 310                 315                 320 


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
                325                 330                 335     


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
            340                 345                 350         


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
        355                 360                 365             


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
    370                 375                 380                 


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
385                 390                 395                 400 


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
                405                 410                 415     


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
            420                 425                 430         


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
        435                 440                 445             


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
    450                 455                 460                 


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
465                 470                 475                 480 


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
                485                 490                 495     


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
            500                 505                 510         


Asn Ala Glu Ala Ala Thr Arg 
        515                 


<210>  181
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mex_helicase

<400>  181

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Ala 
            100                 105                 110         


Gly Thr Leu Ile Lys Thr Pro Lys Gly Pro Val Pro Ile Glu Gln Ile 
        115                 120                 125             


Gln Ser Gly Asp Leu Val Phe Asn Ala Ile Gly Ile Gly Val Val Glu 
    130                 135                 140                 


Gly Ile Val Cys Gln Gln Lys Gln Thr Ile Thr Leu Glu Leu Ser Asp 
145                 150                 155                 160 


Gly Thr Ser Ile Val Cys Thr His Asp His Pro Phe Phe Cys Pro Arg 
                165                 170                 175     


Gly Trp Val Ala Ala Gly Asp Leu Glu Val Gly Ser Gly Leu Phe Ser 
            180                 185                 190         


His Glu Asp Leu Arg Arg Leu Trp Ser Gly Gly Ala Ser Leu Gly Leu 
        195                 200                 205             


Glu Ser Gly Ser Ser Asp Gly Arg Gly Ala Val Arg Ser Ser Glu Val 
    210                 215                 220                 


Leu Leu Arg Ile Leu Arg Glu Glu Ala Arg Glu Pro Asp Ala Gly Tyr 
225                 230                 235                 240 


Cys Gly Pro Ala Glu Asp Val Arg Asn Ala Ser Thr Asp Arg Ala His 
                245                 250                 255     


Ala Glu Gly Ala Trp Trp Gln Trp Gln Ala Asp Pro Ile Ala Ser Asp 
            260                 265                 270         


Glu Ala Ala Arg Ser Ala Gly Arg Arg Val Ala Asp Arg Val Arg Asp 
        275                 280                 285             


Glu Asp Arg Arg Glu Ala Arg Pro Glu Pro Thr Ala Val Leu Leu Gln 
    290                 295                 300                 


Asp Arg His Cys Glu Pro Leu Ala Asn Asp Arg Asn Arg Ser Gly Arg 
305                 310                 315                 320 


Glu His Ser Ser Arg Gly Thr Gly Glu Ala Glu Gly Gln Arg Gln Gly 
                325                 330                 335     


Asp Val Pro Cys Ser Val Arg Val Val Ser Ile Ser Arg Glu Glu Arg 
            340                 345                 350         


Gly Gly Pro Glu Ala Val Tyr Asn Leu Arg Val Ser Gly His Pro Ser 
        355                 360                 365             


Tyr Phe Ala Gly Gly Val Leu Val His Asn Ser Gly Val Lys Val Ala 
    370                 375                 380                 


Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly 
385                 390                 395                 400 


Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly 
                405                 410                 415     


His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile 
            420                 425                 430         


Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val 
        435                 440                 445             


Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu 
    450                 455                 460                 


Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly 
465                 470                 475                 480 


Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr 
                485                 490                 495     


Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly 
            500                 505                 510         


Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala 
        515                 520                 525             


Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly 
    530                 535                 540                 


Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly 
545                 550                 555                 560 


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
                565                 570                 575     


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
            580                 585                 590         


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
        595                 600                 605             


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    610                 615                 620                 


<210>  182
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mhu_Pol-II

<400>  182

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe His Gly 
            100                 105                 110         


Asp Thr Leu Ile Glu Ile Tyr Ala Asp Gly Ile Leu Glu Glu Ile Pro 
        115                 120                 125             


Ile Arg Arg Phe Val Leu Glu His Leu Asp Leu Ser Gln Ala Gly Val 
    130                 135                 140                 


Asp Ala Leu Gly Thr Phe Tyr Ala Asp Pro Val Arg Pro Ala His Val 
145                 150                 155                 160 


Arg Ser Val Asp Thr Gly Gly Ile Pro His Leu Arg Lys Ile Thr Ser 
                165                 170                 175     


Val Ser Val His Lys Ala Pro Ala Asn Leu Ile Gln Phe Ser Thr Ser 
            180                 185                 190         


Arg Gly Lys Asn Leu Leu Val Thr Pro Asp His Ala Met Leu Val Trp 
        195                 200                 205             


Asp Val Ser Tyr Leu Arg Lys Ile Arg Ala Leu Glu Val Lys Ile Gly 
    210                 215                 220                 


Asp Ala Val Pro Val Trp Glu Ser Gly Val Val Ile Ser Asp Arg Ile 
225                 230                 235                 240 


Val Ser Ile Asp Tyr Val Pro Cys Glu Asp Glu Arg Val Tyr Cys Leu 
                245                 250                 255     


Thr Val Asp Arg Asp His Asn Val Val Gly Asn Gly Ile Phe Thr Gly 
            260                 265                 270         


Gln Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
        275                 280                 285             


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
    290                 295                 300                 


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
305                 310                 315                 320 


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
                325                 330                 335     


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
            340                 345                 350         


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
        355                 360                 365             


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
    370                 375                 380                 


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
385                 390                 395                 400 


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
                405                 410                 415     


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
            420                 425                 430         


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
        435                 440                 445             


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
    450                 455                 460                 


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
465                 470                 475                 480 


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
                485                 490                 495     


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
            500                 505                 510         


Asn Ala Glu Ala Ala Thr Arg 
        515                 


<210>  183
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_GF-6P

<400>  183

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu His Pro 
            100                 105                 110         


Asp Thr Tyr Val Ile Leu Pro Asp Gly Arg Met Lys Lys Ile Ser Glu 
        115                 120                 125             


Ile Asp Glu Asp Glu Val Leu Ser Val Asn Phe Glu Asp Leu Lys Leu 
    130                 135                 140                 


Tyr Asn Lys Lys Ile Lys Lys Phe Lys His Lys Ala Pro Lys Ile Leu 
145                 150                 155                 160 


Tyr Lys Ile Lys Thr Ala Phe Ser Glu Leu Ile Thr Thr Gly Glu His 
                165                 170                 175     


Lys Leu Phe Val Val Glu Asn Gly Lys Ile Val Glu Lys Cys Val Lys 
            180                 185                 190         


Asp Leu Asn Gly Ser Glu Leu Ile Gly Val Val Arg Lys Leu Asn Tyr 
        195                 200                 205             


Ser Phe Asn Asp Asn Val Glu Phe Lys Asp Val Tyr Val Glu Arg His 
    210                 215                 220                 


Tyr Lys Leu Asp Glu Thr Ile Arg Asn Lys Leu Arg Lys Val Arg Glu 
225                 230                 235                 240 


Lys Leu Gly Leu Thr Arg Lys Asp Val Glu Lys Leu Cys Gly Val Lys 
                245                 250                 255     


Glu Ile Tyr Ile Val Lys Ile Glu Thr Gly Lys Leu Glu Ser Ile Glu 
            260                 265                 270         


Glu Glu Arg Leu Lys Lys Leu Cys Ser Leu Tyr Gly Ile Asn Phe Glu 
        275                 280                 285             


Glu Ile Ile Tyr Arg Asp Asn Leu His Tyr Thr Asn Pro Val Lys Phe 
    290                 295                 300                 


Pro Lys Thr Pro Thr Pro Glu Leu Met Gln Ile Ile Gly Tyr Ile Ile 
305                 310                 315                 320 


Gly Asp Gly His Phe Pro Ser Asn Arg Met Leu Arg Leu Lys Asp Glu 
                325                 330                 335     


Arg Lys Glu Val Leu Glu Glu Tyr Asn Gln Leu Phe Lys Thr Val Phe 
            340                 345                 350         


Asn Leu Glu Gly Asn Ile Lys Lys Gly Asp Gly Asn Tyr Tyr Ile Leu 
        355                 360                 365             


Glu Ile Asn Ser Lys Tyr Leu Ile Asp Trp Phe Arg Glu Asn Ile Pro 
    370                 375                 380                 


Glu Leu Phe Asn Lys Thr Gly Asn Glu Arg Thr Pro Glu Phe Val Phe 
385                 390                 395                 400 


Arg Leu Asn Asn Asp Leu Val Ala Ser Tyr Leu Arg Gly Ile Phe Asp 
                405                 410                 415     


Ala Glu Gly Tyr Ile Arg Ala Glu Ala Lys Gln Ile Gly Ile Gly Met 
            420                 425                 430         


Thr Ser Lys Cys Phe Ile Lys Glu Ile Gln Phe Leu Leu Leu Arg Phe 
        435                 440                 445             


Gly Ile Leu Ala Ser Tyr Ser Lys Ile Lys Arg Lys Glu Glu Asn Trp 
    450                 455                 460                 


Asn Asn Thr His Lys Leu Leu Ile Ser Asp Lys Lys Ser Phe Glu Leu 
465                 470                 475                 480 


Phe Lys Lys Tyr Ile Gly Phe Thr Ala Lys Asp Lys Met Glu Lys Leu 
                485                 490                 495     


Glu Ala Ile Leu Asn Lys Met Lys Gly Leu Asn Phe Arg Tyr Ile Ser 
            500                 505                 510         


Ile Pro Leu Thr Lys Lys Glu Ile Arg Glu Phe Val Gly Val Pro Leu 
        515                 520                 525             


Lys Thr Ile Lys Asn Gly Asp Asn Tyr Cys Thr Asp Tyr Thr Ile Glu 
    530                 535                 540                 


Lys Ile Ile Glu Glu Leu Asn Ser Lys Gly Leu Tyr Asp Lys Ala Glu 
545                 550                 555                 560 


Tyr Leu Lys Arg Phe Leu Asp Ala Asp Ile Val Trp Thr Lys Phe Lys 
                565                 570                 575     


Ile Glu Glu Val Glu Ser Asp Val Glu Tyr Val Tyr Asp Leu Glu Val 
            580                 585                 590         


Glu Asp Tyr His Asn Phe Ile Gly Asn Leu Ile Ile Asn His Asn Ser 
        595                 600                 605             


Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp 
    610                 615                 620                 


Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr 
625                 630                 635                 640 


Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala 
                645                 650                 655     


Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu 
            660                 665                 670         


Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser 
        675                 680                 685             


Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala 
    690                 695                 700                 


Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala 
705                 710                 715                 720 


Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly 
                725                 730                 735     


Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
            740                 745                 750         


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
        755                 760                 765             


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
    770                 775                 780                 


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
785                 790                 795                 800 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                805                 810                 815     


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            820                 825                 830         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        835                 840                 845             


Glu Ala Ala Thr Arg 
    850             


<210>  184
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_Helicase

<400>  184

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Asn Ala 
            100                 105                 110         


Asn Thr Glu Ile Leu Gln Glu Ser Gly Phe Arg Lys Ile Thr Glu Leu 
        115                 120                 125             


Asn Lys Asp Glu Lys Val Phe Ala Leu Cys Gly Lys Glu Ile Lys Pro 
    130                 135                 140                 


Val Asp Gly Trp Lys Val His Lys Thr Pro Gln His Glu Tyr Asn Ile 
145                 150                 155                 160 


Val Val Lys Thr Val Asn Gly Leu Glu Ile Thr Thr Thr Pro Asn His 
                165                 170                 175     


Ile Phe Leu Val Lys Glu Asn Gly Ser Leu Lys Glu Lys Glu Ala Lys 
            180                 185                 190         


Asp Leu Lys Val Gly Asp Tyr Val Ala Thr Val Asp Arg Ile Arg Val 
        195                 200                 205             


Lys Glu Lys Asp Ile Asp Leu Ser Asn Gly Asp Leu Tyr Phe Ile Gly 
    210                 215                 220                 


Tyr Phe Ile Gly Asp Gly Tyr Thr Gly Val Ile Glu Lys Asn Thr Leu 
225                 230                 235                 240 


Lys Ala Thr Pro Asp Leu Ala Phe Asn Pro Lys Tyr Pro Pro Asn Phe 
                245                 250                 255     


Asp Asp Ser Glu Leu His Lys Lys Tyr Phe Leu Lys Cys Arg Ile Ser 
            260                 265                 270         


Lys Gly Val Ala His Tyr Ile Tyr Ser Lys Lys Leu Arg Lys Ile Phe 
        275                 280                 285             


Asn Lys Leu Asn Met Leu Thr Lys Asp Asn Lys Asn Ile Asp Ala Phe 
    290                 295                 300                 


Cys Asn Leu Pro Leu Asp Lys Leu Ala Tyr Leu Ile Ala Gly Leu Phe 
305                 310                 315                 320 


Asp Ser Asp Gly Tyr Ile Tyr Leu Asn Arg Lys Asn Ile Glu Phe Tyr 
                325                 330                 335     


Ser Ile Ser Glu Lys Leu Val Glu Gln Leu Gln Phe Val Leu Leu Arg 
            340                 345                 350         


Phe Gly Ile His Ser Ser Ile Arg Lys Lys Lys Thr Lys Thr Met Val 
        355                 360                 365             


Ser Pro Thr Asn Gly Lys Glu Tyr Lys Cys Lys Asp Ile Tyr Val Leu 
    370                 375                 380                 


Thr Ile Arg Asp Phe Met Ser Ile Lys Arg Phe Tyr Glu Asn Ile Pro 
385                 390                 395                 400 


Leu Arg His Glu Glu Lys Arg Arg Lys Leu Glu Glu Ile Ile Lys Asn 
                405                 410                 415     


Lys Glu Ile Gly Gln Ile Pro Ser Glu Phe Val Ala Leu Arg Phe Thr 
            420                 425                 430         


Pro Ile Ala Lys Ile Trp Cys Asp Cys Gly Phe Ser Val Asp Leu Thr 
        435                 440                 445             


Met Phe Lys Pro Arg Thr Lys Arg Gln Arg Glu Leu Asn Lys Lys Arg 
    450                 455                 460                 


Val Lys Leu Leu Phe Glu Leu Leu Asp Gly Lys Lys Leu Ile Thr Asn 
465                 470                 475                 480 


Tyr Lys Glu Tyr Tyr Ser Lys Arg Lys Asn Pro Tyr Phe Asp Phe Ile 
                485                 490                 495     


Val Arg Glu Lys Ile Asn Gly Asn Asn Tyr Tyr Ser Leu Asn Glu Lys 
            500                 505                 510         


Gly Arg Val Leu Met Ser Leu Leu Asn Lys His Ile Lys Asp Lys Glu 
        515                 520                 525             


Asn Leu Glu Glu Met Tyr Asn Phe Leu Val Asn Leu Glu Lys Cys Pro 
    530                 535                 540                 


Ile Cys Gly Lys Pro Ile His Lys Glu Met Arg Tyr Ser Trp Lys Lys 
545                 550                 555                 560 


Glu Cys Tyr Asp Gly Asp Ile Tyr Trp Asp Arg Ile Lys Glu Ile Lys 
                565                 570                 575     


Lys Ile Lys Val Asn Asp Lys Tyr Ala Tyr Asp Ile Glu Leu Pro Asp 
            580                 585                 590         


Asp Gly Ser Asn Ser His Tyr Ile Val Ala Asn Gly Phe Ile Val His 
        595                 600                 605             


Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
    610                 615                 620                 


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
625                 630                 635                 640 


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
                645                 650                 655     


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
            660                 665                 670         


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
        675                 680                 685             


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
    690                 695                 700                 


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
705                 710                 715                 720 


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
                725                 730                 735     


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
            740                 745                 750         


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
        755                 760                 765             


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
    770                 775                 780                 


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
785                 790                 795                 800 


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
                805                 810                 815     


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
            820                 825                 830         


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
        835                 840                 845             


Asn Ala Glu Ala Ala Thr Arg 
    850                 855 


<210>  185
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_Hyp-1

<400>  185

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Pro Pro 
            100                 105                 110         


Asp Thr Leu Leu Ile Leu Glu Asn Gly Phe Lys Arg Ile Val Asp Ile 
        115                 120                 125             


Lys Val Gly Asp Lys Val Leu Thr His Glu Asn Arg Phe Lys Lys Val 
    130                 135                 140                 


Glu Lys Val Tyr Lys Arg Arg Tyr Ile Gly Asp Ile Ile Lys Ile Lys 
145                 150                 155                 160 


Val Arg Tyr Phe Pro Glu Glu Ile Ile Leu Thr Pro Glu His Pro Val 
                165                 170                 175     


Tyr Ala Ile Lys Thr Glu Lys Arg Cys Asp Gly Ser His Gly Ile Cys 
            180                 185                 190         


Lys Phe Asn Cys Leu Thr Gln Tyr Thr Asn Pro Ser Cys Lys Lys Arg 
        195                 200                 205             


Tyr Arg Lys Tyr Lys Arg Glu Trp Ile Ile Ala Lys Asp Leu Lys Val 
    210                 215                 220                 


Gly Asp Val Ile Val Tyr Pro Ile Pro Asn Arg Val Arg Asp Ile Lys 
225                 230                 235                 240 


Tyr Leu Ser Leu Asp Lys Tyr Leu Ser Asn Ile Lys Arg Glu Phe Cys 
                245                 250                 255     


Arg Ser Arg Ile Pro Glu Lys Ile Glu Val Ser Glu Glu Phe Cys Arg 
            260                 265                 270         


Leu Val Gly Tyr Phe Leu Ser Glu Gly Tyr Cys Phe Arg Asp Gly Ile 
        275                 280                 285             


Gly Phe Ala Leu Gly Glu Asn Glu Lys Lys Ile Ile Asp Asp Ile Glu 
    290                 295                 300                 


Tyr Leu Met Lys Lys Ile Phe Asn Leu Lys Pro Lys Ile Arg Asp Asp 
305                 310                 315                 320 


Gly Arg Ser Glu Gly Ile Glu Leu Lys Tyr Tyr Ser Arg Val Leu Arg 
                325                 330                 335     


Asp Phe Phe Gly Asp Met Phe Tyr Cys Gly Asp Glu Lys Arg Ala Trp 
            340                 345                 350         


Asn Lys Ala Leu Pro Asn Glu Phe Leu Tyr Leu Pro Lys Asn Lys Gln 
        355                 360                 365             


Leu Gln Ile Phe Ile Gly Trp Trp Arg Gly Asp Lys Gly Val Thr Thr 
    370                 375                 380                 


Ser Glu Ile Leu Met Asn Gln Leu Arg Leu Ile Ser Leu Arg Leu Gly 
385                 390                 395                 400 


Phe Ile Ile Thr Phe Ser Lys His Val Pro Lys Asn Pro Lys Ile Gly 
                405                 410                 415     


Asp Arg Glu Val Ile Lys Tyr His Ala Arg Trp Gln Gly Arg Val Ser 
            420                 425                 430         


Ile Leu Asp Glu Lys Ile Val Asp Glu Leu Lys Asn Glu Asp Ile Lys 
        435                 440                 445             


Leu Pro Lys Lys Asp Val Arg Tyr Gly Trp Ile Lys Gly Asn Tyr Leu 
    450                 455                 460                 


Tyr Ala Pro Ile Ile Arg Ile Gly Arg Glu Tyr Tyr Asp Gly Phe Val 
465                 470                 475                 480 


Tyr Asn Leu Glu Val Glu Asp Asp Ser Ser Tyr Val Thr Val Ser Gly 
                485                 490                 495     


Thr Leu His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
            500                 505                 510         


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
        515                 520                 525             


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
    530                 535                 540                 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
545                 550                 555                 560 


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
                565                 570                 575     


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
            580                 585                 590         


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
        595                 600                 605             


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
    610                 615                 620                 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
625                 630                 635                 640 


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
                645                 650                 655     


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
            660                 665                 670         


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
        675                 680                 685             


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
    690                 695                 700                 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
705                 710                 715                 720 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
                725                 730                 735     


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            740                 745     


<210>  186
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_IF2

<400>  186

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Met Pro 
            100                 105                 110         


His Glu Lys Val Leu Thr Glu Tyr Gly Glu Ile Lys Ile Glu Asp Leu 
        115                 120                 125             


Phe Lys Ile Gly Lys Glu Ile Val Glu Lys Asp Glu Leu Lys Glu Ile 
    130                 135                 140                 


Arg Lys Leu Asn Ile Lys Val His Thr Leu Asn Glu Asn Gly Glu Ile 
145                 150                 155                 160 


Lys Ile Ile Asn Ala Pro Tyr Val Trp Lys Leu Lys His Lys Gly Lys 
                165                 170                 175     


Met Ile Lys Val Lys Leu Lys Asn Trp His Ser Ile Thr Thr Thr Pro 
            180                 185                 190         


Glu His Pro Phe Leu Thr Asn Asn Gly Trp Ile Lys Ala Glu Asn Ile 
        195                 200                 205             


Lys Lys Gly Met Tyr Val Ala Ile Pro Arg Lys Ile Tyr Gly Asn Glu 
    210                 215                 220                 


Asp Phe Glu Lys Phe Ile Glu Phe Ile Asn Ser Lys Ile Leu Thr Asn 
225                 230                 235                 240 


Glu Leu Ile Val Lys Val Asn Glu Lys Asp Leu Lys Asn Val Glu Leu 
                245                 250                 255     


Pro Ser Thr Lys Ile Tyr Lys Lys Gln Lys Asn Val Phe Arg Ser Glu 
            260                 265                 270         


Asp Ile Ile Glu His Asn Leu Asn Ile Glu Lys Ile Ser Phe Ser Pro 
        275                 280                 285             


Arg Ile His Arg Cys Gly Lys Pro Gln His Tyr Ile Lys Leu Pro Lys 
    290                 295                 300                 


Ser Leu Asn Glu Trp Lys Ala Ile Phe Tyr Phe Ala Gly Val Met Phe 
305                 310                 315                 320 


Gly Asp Gly Cys Val Asp Arg Ile Ala Asn Asn Asp Glu Glu Val Phe 
                325                 330                 335     


Asn Lys Leu Lys Ser Leu Asn Asn Leu Gly Ile Glu Val Glu Arg Ile 
            340                 345                 350         


Lys Arg Lys Ser Ser Tyr Glu Ile Ile Phe Lys Asn Gly Lys Asn Ala 
        355                 360                 365             


Leu Ile Asn Leu Leu Lys Ile Leu Phe Asp Tyr Pro Ser Glu Lys Lys 
    370                 375                 380                 


Ser His Asn Ile Lys Ile Pro Gln Ile Leu Tyr Ile Ala Pro Lys Glu 
385                 390                 395                 400 


Leu Val Ala Glu Phe Ile Lys Gly Tyr Phe Asp Ala Asp Gly Tyr Val 
                405                 410                 415     


Asn Leu Arg Gln Asn Arg Ile Glu Val Ile Ser Ala Ser Lys Glu Phe 
            420                 425                 430         


Ile Glu Gly Leu Ser Ile Leu Leu Leu Arg Phe Glu Ile Thr Ser Lys 
        435                 440                 445             


Ile Tyr Glu Ile Lys Lys Ser Tyr Lys Glu Thr Lys Lys Lys Tyr Tyr 
    450                 455                 460                 


Gln Leu Asn Ile Val Gly Lys Arg Asn Leu Lys Asn Phe Lys Asn Ile 
465                 470                 475                 480 


Gly Phe Ser Ile Lys Tyr Lys Glu Glu Asn Leu Asn Lys Ile Ile Glu 
                485                 490                 495     


Lys Ser Arg Lys Ser Glu Lys Tyr Pro Ile Asn Lys Asp Met Lys Arg 
            500                 505                 510         


Leu Arg Ile Leu Phe Gly Met Thr Arg Asn Glu Val Asn Val Ser Tyr 
        515                 520                 525             


Tyr Ala Lys Tyr Glu Asn Gly Lys Glu Ile Pro Ser Tyr Glu Ile Val 
    530                 535                 540                 


Lys Lys Phe Leu Asn Ser Leu Lys Pro Lys Asn Leu Asp Lys Lys Ile 
545                 550                 555                 560 


Lys Val Leu Glu Gly Lys Glu Arg Asp Val Asn Tyr Leu Lys Ala Phe 
                565                 570                 575     


Glu Ser Asp Gly Leu Ile Glu Asn Gly Arg Leu Thr Lys Leu Gly Arg 
            580                 585                 590         


Glu Ala Leu Asn Ile Trp Lys Asn His Glu Phe Gly Lys Glu Asn Ile 
        595                 600                 605             


Asp Tyr Met Lys Ser Leu Ile Glu Asn Ile Ala Phe Val Glu Val Glu 
    610                 615                 620                 


Asp Val Glu Ile Ile Asp Tyr Asp Gly Tyr Val Tyr Asp Leu Thr Thr 
625                 630                 635                 640 


Glu Thr His Asn Phe Ile Ala Asn Gly Ile Val Val His Asn Ser Gly 
                645                 650                 655     


Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu 
            660                 665                 670         


Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln 
        675                 680                 685             


Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu 
    690                 695                 700                 


Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr 
705                 710                 715                 720 


Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile 
                725                 730                 735     


Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn 
            740                 745                 750         


Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val 
        755                 760                 765             


Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn 
    770                 775                 780                 


Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met 
785                 790                 795                 800 


Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln 
                805                 810                 815     


Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser 
            820                 825                 830         


Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
        835                 840                 845             


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
    850                 855                 860                 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
865                 870                 875                 880 


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
                885                 890                 895     


Ala Ala Thr Arg 
            900 


<210>  187
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_Klba

<400>  187

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ala Leu Ala Tyr 
            100                 105                 110         


Asp Glu Pro Ile Tyr Leu Ser Asp Gly Asn Ile Ile Asn Ile Gly Glu 
        115                 120                 125             


Phe Val Asp Lys Phe Phe Lys Lys Tyr Lys Asn Ser Ile Lys Lys Glu 
    130                 135                 140                 


Asp Asn Gly Phe Gly Trp Ile Asp Ile Gly Asn Glu Asn Ile Tyr Ile 
145                 150                 155                 160 


Lys Ser Phe Asn Lys Leu Ser Leu Ile Ile Glu Asp Lys Arg Ile Leu 
                165                 170                 175     


Arg Val Trp Arg Lys Lys Tyr Ser Gly Lys Leu Ile Lys Ile Thr Thr 
            180                 185                 190         


Lys Asn Arg Arg Glu Ile Thr Leu Thr His Asp His Pro Val Tyr Ile 
        195                 200                 205             


Ser Lys Thr Gly Glu Val Leu Glu Ile Asn Ala Glu Met Val Lys Val 
    210                 215                 220                 


Gly Asp Tyr Ile Tyr Ile Pro Lys Asn Asn Thr Ile Asn Leu Asp Glu 
225                 230                 235                 240 


Val Ile Lys Val Glu Thr Val Asp Tyr Asn Gly His Ile Tyr Asp Leu 
                245                 250                 255     


Thr Val Glu Asp Asn His Thr Tyr Ile Ala Gly Lys Asn Glu Gly Phe 
            260                 265                 270         


Ala Val Ser Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        275                 280                 285             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    290                 295                 300                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
305                 310                 315                 320 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                325                 330                 335     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            340                 345                 350         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        355                 360                 365             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    370                 375                 380                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
385                 390                 395                 400 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                405                 410                 415     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            420                 425                 430         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        435                 440                 445             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    450                 455                 460                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
465                 470                 475                 480 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                485                 490                 495     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            500                 505                 510         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        515                 520         


<210>  188
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_PEP

<400>  188

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Ile Glu Gly 
            100                 105                 110         


Asp Ala Lys Ile Leu Thr Asp Arg Gly Phe Leu Lys Met Lys Glu Val 
        115                 120                 125             


Tyr Lys Leu Val Lys Asn Gly Glu Lys Leu Lys Val Leu Gly Leu Asn 
    130                 135                 140                 


Ala Glu Thr Leu Lys Thr Glu Trp Lys Glu Ile Ile Asp Ala Gln Lys 
145                 150                 155                 160 


Arg Glu Ala Arg Arg Tyr Glu Ile Gly Val Tyr Arg Lys Asn Lys Asn 
                165                 170                 175     


Thr Lys Asp Thr Ile Lys Ile Thr Pro Asp His Lys Phe Pro Val Phe 
            180                 185                 190         


Val Asn Gly Glu Leu Ser Lys Val Gln Leu Cys Asp Ile Ile Asp Asn 
        195                 200                 205             


Asn Leu Ser Val Leu Ser Ile Asp Tyr Ile Pro Met Ile Glu Glu Lys 
    210                 215                 220                 


Tyr Glu Ser Leu Ala Glu Val Met Tyr Leu Gly Gly Ala Val Leu Ser 
225                 230                 235                 240 


Asp Gly His Ile Val Arg Arg Asn Gly Lys Pro Ile Arg Val Arg Phe 
                245                 250                 255     


Thr Gln Lys Asp Thr Glu Glu Lys Lys Asp Phe Ile Glu Lys Val Lys 
            260                 265                 270         


Gly Asp Val Lys Leu Ile Gly Gly Asn Phe Ile Glu Ile Ser Asn Arg 
        275                 280                 285             


Asn Asn Val Ile Glu Tyr Gln Thr Ser Arg Lys Ile Pro Ser Glu Ile 
    290                 295                 300                 


Leu Gly Phe Ile Glu Val Asn Ile Asn Thr Ile Pro Leu Tyr Ala Thr 
305                 310                 315                 320 


Lys Asp Glu Ile Ala Asp Leu Ile Ala Gly Phe Val Asp Gly Asp Gly 
                325                 330                 335     


Cys Leu Ser Gly Lys Arg Arg Val Glu Ile Tyr Gln Asn Ser Ser His 
            340                 345                 350         


Ile Lys Lys Ile Glu Gly Leu Ile Val Gly Leu Tyr Arg Leu Gly Ile 
        355                 360                 365             


Ile Pro Arg Leu Arg Tyr Lys Arg Ser Ser Thr Ala Thr Ile Tyr Phe 
    370                 375                 380                 


Asn Asn Asn Leu Glu Thr Ile Leu Gln Arg Thr Arg Arg Ile Lys Leu 
385                 390                 395                 400 


Asp Lys Leu Lys Glu Phe Lys Lys Pro Val Glu Asp Lys Lys Leu Ile 
                405                 410                 415     


Asp Ile Ser Gln Ile Leu Pro Glu Leu Lys Glu Phe Asp Tyr Lys Gly 
            420                 425                 430         


Tyr Leu Tyr Lys Thr Tyr Lys Glu Lys Leu Phe Ile Gly Ile Asn Lys 
        435                 440                 445             


Leu Glu Glu Tyr Leu Ser Lys Ile Asp Lys Asp Gly Ile Glu Arg Ile 
    450                 455                 460                 


Lys Gln Lys Ile Lys Leu Leu Lys Glu Ser Asp Ile Tyr Ser Ile Arg 
465                 470                 475                 480 


Ile Lys Lys Val Gly Glu Asp Tyr Gly Glu Val Tyr Asn Ile Thr Val 
                485                 490                 495     


Lys Ala Glu Asn Glu Phe Asn His Asn Tyr Val Val Trp Thr Lys His 
            500                 505                 510         


Tyr Thr Pro Ile Val Val Phe Asn Ser Gly Val Lys Val Ala Val Leu 
        515                 520                 525             


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
    530                 535                 540                 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
545                 550                 555                 560 


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
                565                 570                 575     


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
            580                 585                 590         


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
        595                 600                 605             


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
    610                 615                 620                 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
625                 630                 635                 640 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
                645                 650                 655     


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
            660                 665                 670         


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
        675                 680                 685             


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
    690                 695                 700                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
705                 710                 715                 720 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                725                 730                 735     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            740                 745                 750         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760                 765     


<210>  189
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_Pol-1

<400>  189

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys His Pro Lys 
            100                 105                 110         


Gly Thr Lys Val Val Val Lys Gly Lys Gly Ile Val Asn Ile Glu Asp 
        115                 120                 125             


Val Lys Glu Gly Asn Tyr Val Leu Gly Ile Asp Gly Trp Gln Lys Val 
    130                 135                 140                 


Lys Lys Val Trp Lys Tyr Glu Tyr Glu Gly Glu Leu Ile Asn Val Asn 
145                 150                 155                 160 


Gly Leu Lys Cys Thr Pro Asn His Lys Ile Pro Leu Arg Tyr Lys Ile 
                165                 170                 175     


Lys His Lys Lys Ile Asn Lys Asn Asp Tyr Leu Val Arg Asp Ile Tyr 
            180                 185                 190         


Ala Lys Ser Leu Leu Thr Lys Phe Lys Gly Glu Gly Lys Leu Ile Leu 
        195                 200                 205             


Cys Lys Asp Phe Glu Thr Ile Gly Asn Tyr Glu Lys Tyr Ile Asn Asp 
    210                 215                 220                 


Met Asp Glu Asp Phe Ile Leu Lys Ser Glu Leu Ile Gly Ile Leu Leu 
225                 230                 235                 240 


Ala Glu Gly His Leu Leu Arg Arg Asp Ile Glu Tyr Phe Asp Ser Ser 
                245                 250                 255     


Arg Gly Lys Lys Arg Ile Ser His Gln Tyr Arg Val Glu Ile Thr Val 
            260                 265                 270         


Asn Glu Asp Glu Lys Asp Phe Ile Glu Lys Ile Lys Tyr Ile Phe Lys 
        275                 280                 285             


Lys Leu Phe Asn Tyr Glu Leu Tyr Val Arg Arg Lys Lys Gly Thr Lys 
    290                 295                 300                 


Ala Ile Thr Leu Gly Cys Ala Lys Lys Asp Ile Tyr Leu Lys Ile Glu 
305                 310                 315                 320 


Glu Ile Leu Lys Asn Lys Glu Lys Tyr Leu Pro Asn Ala Ile Leu Arg 
                325                 330                 335     


Gly Phe Phe Glu Gly Asp Gly Tyr Val Asn Thr Val Arg Arg Ala Val 
            340                 345                 350         


Val Val Asn Gln Gly Thr Asn Asn Tyr Asp Lys Ile Lys Phe Ile Ala 
        355                 360                 365             


Ser Leu Leu Asp Arg Leu Gly Ile Lys Tyr Ser Phe Tyr Thr Tyr Ser 
    370                 375                 380                 


Tyr Glu Glu Arg Gly Lys Lys Leu Lys Arg Tyr Val Ile Glu Ile Phe 
385                 390                 395                 400 


Ser Lys Gly Asp Leu Ile Lys Phe Ser Ile Leu Ile Ser Phe Ile Ser 
                405                 410                 415     


Arg Arg Lys Asn Asn Leu Leu Asn Glu Ile Ile Arg Gln Lys Thr Leu 
            420                 425                 430         


Tyr Lys Ile Gly Asp Tyr Gly Phe Tyr Asp Leu Asp Asp Val Cys Val 
        435                 440                 445             


Ser Leu Glu Ser Tyr Lys Gly Glu Val Tyr Asp Leu Thr Leu Glu Gly 
    450                 455                 460                 


Arg Pro Tyr Tyr Phe Ala Asn Gly Ile Leu Thr His Asn Ser Gly Val 
465                 470                 475                 480 


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
                485                 490                 495     


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
            500                 505                 510         


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
        515                 520                 525             


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
    530                 535                 540                 


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
545                 550                 555                 560 


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
                565                 570                 575     


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
            580                 585                 590         


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
        595                 600                 605             


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
    610                 615                 620                 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
625                 630                 635                 640 


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
                645                 650                 655     


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            660                 665                 670         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        675                 680                 685             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    690                 695                 700                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
705                 710                 715                 720 


Ala Thr Arg 
            


<210>  190
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_Pol-2

<400>  190

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Ile Leu Pro 
            100                 105                 110         


Asp Glu Tyr Leu Thr Ile Ile Glu Glu Asp Gly Ile Lys Val Val Lys 
        115                 120                 125             


Ile Gly Glu Tyr Ile Asp Asp Leu Met Arg Lys His Lys Asp Lys Ile 
    130                 135                 140                 


Lys Phe Ser Gly Ile Ser Glu Ile Leu Glu Thr Lys Asn Leu Lys Thr 
145                 150                 155                 160 


Phe Ser Phe Asp Lys Ile Thr Lys Lys Cys Glu Ile Lys Lys Val Lys 
                165                 170                 175     


Ala Leu Ile Arg His Pro Tyr Phe Gly Lys Ala Tyr Lys Ile Lys Leu 
            180                 185                 190         


Arg Ser Gly Arg Thr Ile Lys Val Thr Arg Gly His Ser Leu Phe Lys 
        195                 200                 205             


Tyr Glu Asn Gly Lys Ile Val Glu Val Lys Gly Asp Asp Val Arg Phe 
    210                 215                 220                 


Gly Asp Leu Ile Val Val Pro Lys Lys Leu Thr Cys Val Asp Lys Glu 
225                 230                 235                 240 


Val Val Ile Asn Ile Pro Lys Arg Leu Ile Asn Ala Asp Glu Glu Glu 
                245                 250                 255     


Ile Lys Asp Leu Val Ile Thr Lys His Lys Asp Lys Ala Phe Phe Val 
            260                 265                 270         


Lys Leu Lys Lys Thr Leu Glu Asp Ile Glu Asn Asn Lys Leu Lys Val 
        275                 280                 285             


Ile Phe Asp Asp Cys Ile Leu Tyr Leu Lys Glu Leu Gly Leu Ile Asp 
    290                 295                 300                 


Tyr Asn Ile Ile Lys Lys Ile Asn Lys Val Asp Ile Lys Ile Leu Asp 
305                 310                 315                 320 


Glu Glu Lys Phe Lys Ala Tyr Lys Lys Tyr Phe Asp Thr Val Ile Glu 
                325                 330                 335     


His Gly Asn Phe Lys Lys Gly Arg Cys Asn Ile Gln Tyr Ile Lys Ile 
            340                 345                 350         


Lys Asp Tyr Ile Ala Asn Ile Pro Asp Lys Glu Phe Glu Asp Cys Glu 
        355                 360                 365             


Ile Gly Ala Tyr Ser Gly Lys Ile Asn Ala Leu Leu Lys Leu Asp Glu 
    370                 375                 380                 


Lys Leu Ala Lys Phe Leu Gly Phe Phe Val Thr Arg Gly Arg Leu Lys 
385                 390                 395                 400 


Lys Gln Lys Leu Lys Gly Glu Thr Val Tyr Glu Ile Ser Val Tyr Lys 
                405                 410                 415     


Ser Leu Pro Glu Tyr Gln Lys Glu Ile Ala Glu Thr Phe Lys Glu Val 
            420                 425                 430         


Phe Gly Ala Gly Ser Met Val Lys Asp Lys Val Thr Met Asp Asn Lys 
        435                 440                 445             


Ile Val Tyr Leu Val Leu Lys Tyr Ile Phe Lys Cys Gly Asp Lys Asp 
    450                 455                 460                 


Lys Lys His Ile Pro Glu Glu Leu Phe Leu Ala Ser Glu Ser Val Ile 
465                 470                 475                 480 


Lys Ser Phe Leu Asp Gly Phe Leu Lys Ala Lys Lys Asn Ser His Lys 
                485                 490                 495     


Gly Thr Ser Thr Phe Met Ala Lys Asp Glu Lys Tyr Leu Asn Gln Leu 
            500                 505                 510         


Met Ile Leu Phe Asn Leu Val Gly Ile Pro Thr Arg Phe Thr Pro Val 
        515                 520                 525             


Lys Asn Lys Gly Tyr Lys Leu Thr Leu Asn Pro Lys Tyr Gly Thr Val 
    530                 535                 540                 


Lys Asp Leu Met Leu Asp Glu Val Lys Glu Ile Glu Ala Phe Glu Tyr 
545                 550                 555                 560 


Ser Gly Tyr Val Tyr Asp Leu Ser Val Glu Asp Asn Glu Asn Phe Leu 
                565                 570                 575     


Val Asn Asn Ile Tyr Ala His Asn Ser Gly Val Lys Val Ala Val Leu 
            580                 585                 590         


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
        595                 600                 605             


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
    610                 615                 620                 


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
625                 630                 635                 640 


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
                645                 650                 655     


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
            660                 665                 670         


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
        675                 680                 685             


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
    690                 695                 700                 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
705                 710                 715                 720 


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
                725                 730                 735     


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
            740                 745                 750         


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
        755                 760                 765             


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
    770                 775                 780                 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
785                 790                 795                 800 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
                805                 810                 815     


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            820                 825                 830 


<210>  191
<211>  902
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_RFC-1

<400>  191

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Gly 
            100                 105                 110         


Asp Thr Lys Val Ile Val Asn Gly Glu Ile Arg Glu Ile Gly Glu Val 
        115                 120                 125             


Ile Glu Glu Ile Ser Asn Gly Lys Phe Gly Val Thr Leu Thr Asn Asn 
    130                 135                 140                 


Leu Lys Val Leu Gly Ile Asp Glu Asp Gly Lys Ile Arg Glu Phe Asp 
145                 150                 155                 160 


Val Gln Tyr Val Tyr Lys Asp Lys Thr Asn Thr Leu Ile Lys Ile Lys 
                165                 170                 175     


Thr Lys Met Gly Arg Glu Leu Lys Val Thr Thr Tyr His Pro Leu Leu 
            180                 185                 190         


Ile Asn His Lys Asn Gly Glu Ile Lys Trp Glu Lys Ala Glu Asn Leu 
        195                 200                 205             


Lys Val Gly Asp Lys Leu Ala Thr Pro Arg Tyr Ile Leu Phe Asn Glu 
    210                 215                 220                 


Ser Asp Tyr Asn Glu Glu Leu Ala Glu Trp Leu Gly Tyr Phe Ile Gly 
225                 230                 235                 240 


Asp Gly His Ala Asp Lys Glu Ser Asn Lys Ile Thr Phe Thr Asn Gly 
                245                 250                 255     


Asp Glu Lys Leu Arg Lys Arg Phe Ala Glu Leu Thr Glu Lys Leu Phe 
            260                 265                 270         


Lys Asp Ala Lys Ile Lys Glu Arg Ile His Lys Asp Arg Thr Pro Asp 
        275                 280                 285             


Ile Tyr Val Asn Ser Lys Glu Ala Val Glu Phe Ile Asp Lys Leu Gly 
    290                 295                 300                 


Leu Arg Gly Lys Lys Ala Asp Lys Val Arg Ile Pro Lys Glu Ile Met 
305                 310                 315                 320 


Arg Ser Asp Ala Leu Arg Ala Phe Leu Arg Ala Tyr Phe Asp Cys Asp 
                325                 330                 335     


Gly Gly Ile Glu Lys His Ser Ile Val Leu Ser Thr Ala Ser Lys Glu 
            340                 345                 350         


Met Ala Glu Asp Leu Val Tyr Ala Leu Leu Arg Phe Gly Ile Ile Ala 
        355                 360                 365             


Lys Leu Arg Glu Lys Val Asn Lys Asn Asn Asn Lys Val Tyr Tyr His 
    370                 375                 380                 


Ile Val Ile Ser Asn Ser Ser Asn Leu Arg Thr Phe Leu Asp Asn Ile 
385                 390                 395                 400 


Gly Phe Ser Gln Glu Arg Lys Leu Lys Lys Leu Leu Glu Ile Ile Lys 
                405                 410                 415     


Asp Glu Asn Pro Asn Leu Asp Val Ile Thr Ile Asp Lys Glu Lys Ile 
            420                 425                 430         


Arg Tyr Ile Arg Asp Arg Leu Lys Val Lys Leu Thr Arg Asp Ile Glu 
        435                 440                 445             


Lys Asp Asn Trp Ser Tyr Asn Lys Cys Arg Lys Ile Thr Gln Glu Leu 
    450                 455                 460                 


Leu Lys Glu Ile Tyr Tyr Arg Leu Glu Glu Leu Lys Glu Ile Glu Lys 
465                 470                 475                 480 


Ala Leu Glu Glu Asn Ile Leu Ile Asp Trp Asp Glu Val Ala Glu Arg 
                485                 490                 495     


Arg Lys Glu Ile Ala Glu Lys Thr Gly Ile Arg Ser Asp Arg Ile Leu 
            500                 505                 510         


Glu Tyr Ile Arg Gly Lys Arg Lys Pro Ser Leu Lys Asn Tyr Ile Lys 
        515                 520                 525             


Ile Ala Asn Thr Leu Gly Lys Asn Ile Glu Lys Ile Ile Asp Ala Met 
    530                 535                 540                 


Arg Ile Phe Ala Lys Lys Tyr Ser Ser Tyr Ala Glu Ile Gly Lys Met 
545                 550                 555                 560 


Leu Asn Met Trp Asn Ser Ser Ile Lys Ile Tyr Leu Glu Ser Asn Thr 
                565                 570                 575     


Gln Glu Ile Glu Lys Leu Glu Glu Ile Arg Lys Thr Glu Leu Lys Leu 
            580                 585                 590         


Val Lys Glu Ile Leu Asn Asp Glu Lys Leu Ile Asp Ser Ile Gly Tyr 
        595                 600                 605             


Val Leu Phe Leu Ala Ser Asn Glu Ile Tyr Trp Asp Glu Ile Val Glu 
    610                 615                 620                 


Ile Glu Gln Leu Asn Gly Glu Phe Thr Ile Tyr Asp Leu His Val Pro 
625                 630                 635                 640 


Arg Tyr His Asn Phe Ile Gly Gly Asn Leu Pro Thr Ile Leu His Asn 
                645                 650                 655     


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
            660                 665                 670         


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
        675                 680                 685             


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
    690                 695                 700                 


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
705                 710                 715                 720 


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
                725                 730                 735     


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
            740                 745                 750         


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
        755                 760                 765             


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
    770                 775                 780                 


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
785                 790                 795                 800 


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
                805                 810                 815     


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
            820                 825                 830         


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
        835                 840                 845             


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
    850                 855                 860                 


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
865                 870                 875                 880 


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
                885                 890                 895     


Ala Glu Ala Ala Thr Arg 
            900         


<210>  192
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_RFC-2

<400>  192

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Val Ser Lys 
            100                 105                 110         


Asp Thr Pro Ile Leu Val Lys Ile Asp Gly Lys Val Lys Arg Thr Thr 
        115                 120                 125             


Phe Glu Glu Leu Asp Lys Ile Tyr Phe Glu Thr Asn Asp Glu Asn Glu 
    130                 135                 140                 


Met Tyr Lys Lys Val Asp Asn Leu Glu Val Leu Thr Val Asp Glu Asn 
145                 150                 155                 160 


Phe Arg Val Arg Trp Arg Lys Val Ser Thr Ile Ile Arg His Lys Val 
                165                 170                 175     


Asp Lys Ile Leu Arg Ile Lys Phe Glu Gly Gly Tyr Ile Glu Leu Thr 
            180                 185                 190         


Gly Asn His Ser Ile Met Met Leu Asp Glu Asn Gly Leu Val Ala Lys 
        195                 200                 205             


Lys Ala Ser Asp Ile Lys Val Gly Asp Cys Phe Leu Ser Phe Val Ala 
    210                 215                 220                 


Asn Ile Glu Gly Glu Lys Asp Arg Leu Asp Leu Lys Glu Phe Glu Pro 
225                 230                 235                 240 


Lys Asp Ile Thr Ser Arg Val Lys Ile Ile Asn Asp Phe Asp Ile Asp 
                245                 250                 255     


Glu Asp Thr Ala Trp Met Leu Gly Leu Tyr Val Ala Glu Gly Ala Val 
            260                 265                 270         


Gly Phe Lys Gly Lys Thr Ser Gly Gln Val Ile Tyr Thr Leu Gly Ser 
        275                 280                 285             


His Glu His Asp Leu Ile Asn Lys Leu Asn Asp Ile Val Asp Lys Lys 
    290                 295                 300                 


Gly Phe Ser Lys Tyr Glu Asn Phe Thr Gly Ser Gly Phe Asp Arg Lys 
305                 310                 315                 320 


Arg Leu Ser Ala Lys Gln Ile Arg Ile Leu Asn Thr Gln Leu Ala Arg 
                325                 330                 335     


Phe Val Glu Glu Asn Phe Tyr Asp Gly Asn Gly Arg Arg Ala Arg Asn 
            340                 345                 350         


Lys Arg Ile Pro Asp Ile Ile Phe Glu Leu Lys Glu Asn Leu Arg Val 
        355                 360                 365             


Glu Phe Leu Lys Gly Leu Ala Asp Gly Asp Ser Ser Gly Asn Trp Arg 
    370                 375                 380                 


Glu Val Val Arg Ile Ser Ser Lys Ser Asp Asn Leu Leu Ile Asp Thr 
385                 390                 395                 400 


Val Trp Leu Ala Arg Ile Ser Gly Ile Glu Ser Ser Ile Phe Glu Asn 
                405                 410                 415     


Glu Ala Arg Leu Ile Trp Lys Gly Gly Met Lys Trp Lys Lys Ser Asn 
            420                 425                 430         


Leu Leu Pro Ala Glu Pro Ile Ile Lys Met Ile Lys Lys Leu Glu Asn 
        435                 440                 445             


Lys Ile Asn Gly Asn Trp Arg Tyr Ile Leu Arg His Gln Leu Tyr Glu 
    450                 455                 460                 


Gly Lys Lys Arg Val Ser Lys Asp Lys Ile Lys Gln Ile Leu Glu Met 
465                 470                 475                 480 


Val Asn Val Glu Lys Leu Ser Asp Lys Glu Lys Glu Val Tyr Asp Leu 
                485                 490                 495     


Leu Lys Lys Leu Ser Lys Thr Glu Leu Tyr Ala Leu Val Val Lys Glu 
            500                 505                 510         


Ile Glu Ile Ile Asp Tyr Asn Asp Phe Val Tyr Asp Val Ser Val Pro 
        515                 520                 525             


Asn Asn Glu Met Phe Phe Ala Gly Asn Val Pro Ile Leu Leu His Asn 
    530                 535                 540                 


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
545                 550                 555                 560 


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
                565                 570                 575     


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
            580                 585                 590         


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
        595                 600                 605             


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
    610                 615                 620                 


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
625                 630                 635                 640 


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
                645                 650                 655     


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
            660                 665                 670         


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
        675                 680                 685             


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
    690                 695                 700                 


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
705                 710                 715                 720 


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
                725                 730                 735     


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
            740                 745                 750         


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
        755                 760                 765             


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
    770                 775                 780                 


Ala Glu Ala Ala Thr Arg 
785                 790 


<210>  193
<211>  897
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_RFC-3

<400>  193

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Gly 
            100                 105                 110         


Asp Ala Lys Ile Thr Leu Pro Asp Glu Arg Glu Ile Lys Ile Glu Asp 
        115                 120                 125             


Phe Ile Lys Met Phe Glu Glu Arg Lys Leu Lys His Val Leu Asn Arg 
    130                 135                 140                 


Asn Gly Glu Asp Leu Val Leu Ala Gly Val Lys Phe Asn Ser Lys Ile 
145                 150                 155                 160 


Val Asn His Lys Val Tyr Arg Leu Val Leu Glu Ser Gly Arg Glu Ile 
                165                 170                 175     


Glu Ala Thr Gly Asp His Lys Phe Leu Thr Arg Asp Gly Trp Lys Glu 
            180                 185                 190         


Val Tyr Glu Leu Lys Glu Asp Asp Glu Val Leu Val Tyr Pro Ala Leu 
        195                 200                 205             


Glu Gly Val Gly Phe Glu Val Asp Glu Arg Arg Ile Ile Gly Leu Asn 
    210                 215                 220                 


Glu Phe Tyr Glu Phe Leu Thr Asn Tyr Glu Ile Lys Leu Gly Tyr Lys 
225                 230                 235                 240 


Pro Leu Gly Lys Ala Lys Ser Tyr Lys Glu Leu Ile Thr Arg Asp Lys 
                245                 250                 255     


Glu Lys Ile Leu Ser Arg Val Leu Glu Leu Ser Asp Lys Tyr Ser Lys 
            260                 265                 270         


Ser Glu Ile Arg Arg Lys Ile Glu Glu Glu Phe Gly Ile Lys Ile Ser 
        275                 280                 285             


Leu Thr Thr Ile Lys Asn Leu Ile Asn Gly Lys Ile Asp Gly Phe Ala 
    290                 295                 300                 


Leu Lys Tyr Val Arg Lys Ile Lys Glu Leu Gly Trp Asp Glu Ile Thr 
305                 310                 315                 320 


Tyr Asp Asp Glu Lys Ala Gly Ile Phe Ala Arg Leu Leu Gly Phe Ile 
                325                 330                 335     


Ile Gly Asp Gly His Leu Ser Lys Ser Lys Glu Gly Arg Ile Leu Ile 
            340                 345                 350         


Thr Ala Thr Ile Asn Glu Leu Glu Gly Ile Lys Lys Asp Leu Glu Lys 
        355                 360                 365             


Leu Gly Ile Lys Ala Ser Asn Ile Ile Glu Lys Asp Ile Glu His Lys 
    370                 375                 380                 


Leu Asp Gly Arg Glu Ile Lys Gly Lys Thr Ser Phe Ile Tyr Ile Asn 
385                 390                 395                 400 


Asn Lys Ala Phe Tyr Leu Leu Leu Asn Phe Trp Gly Val Glu Ile Gly 
                405                 410                 415     


Asn Lys Thr Ile Asn Gly Tyr Asn Ile Pro Lys Trp Ile Lys Tyr Gly 
            420                 425                 430         


Asn Lys Phe Val Lys Arg Glu Phe Leu Arg Gly Leu Phe Gly Ala Asp 
        435                 440                 445             


Gly Thr Lys Pro Tyr Ile Lys Lys Tyr Asn Ile Asn Gly Ile Lys Leu 
    450                 455                 460                 


Gly Ile Arg Val Glu Asn Ile Ser Lys Asp Lys Thr Leu Glu Phe Phe 
465                 470                 475                 480 


Glu Glu Val Lys Lys Met Leu Glu Glu Phe Glu Val Glu Ser Tyr Ile 
                485                 490                 495     


Lys Val Ser Lys Ile Asp Asn Lys Asn Leu Thr Glu Leu Ile Val Lys 
            500                 505                 510         


Ala Asn Asn Lys Asn Tyr Leu Lys Tyr Leu Ser Arg Ile Ser Tyr Ala 
        515                 520                 525             


Tyr Glu Lys Asp Asn Phe Ala Arg Leu Val Gly Glu Tyr Leu Arg Ile 
    530                 535                 540                 


Lys Glu Ala Tyr Lys Asp Ile Ile Leu Lys Glu Ile Ala Glu Asn Ala 
545                 550                 555                 560 


Leu Lys Glu Ala Asp Gly Glu Lys Ser Leu Arg Glu Leu Ala Arg Lys 
                565                 570                 575     


Tyr Asn Val Pro Val Asp Phe Ile Ile Asn Gln Leu Lys Gly Lys Asp 
            580                 585                 590         


Ile Gly Leu Pro Arg Asn Phe Met Thr Phe Glu Glu Phe Leu Lys Glu 
        595                 600                 605             


Lys Val Val Asp Gly Lys Tyr Val Ser Glu Arg Ile Ile Lys Lys Glu 
    610                 615                 620                 


Cys Ile Gly Tyr Arg Asp Val Tyr Asp Ile Thr Cys His Lys Asp Pro 
625                 630                 635                 640 


Ser Phe Ile Ala Asn Gly Phe Val Ser His Asn Ser Gly Val Lys Val 
                645                 650                 655     


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
            660                 665                 670         


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
        675                 680                 685             


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
    690                 695                 700                 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
705                 710                 715                 720 


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
                725                 730                 735     


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
            740                 745                 750         


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
        755                 760                 765             


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
    770                 775                 780                 


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
785                 790                 795                 800 


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
                805                 810                 815     


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
            820                 825                 830         


Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
        835                 840                 845             


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
    850                 855                 860                 


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
865                 870                 875                 880 


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
                885                 890                 895     


Arg 
    


<210>  194
<211>  848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_r-Gyr

<400>  194

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Pro 
            100                 105                 110         


Asp Thr Tyr Val Val Leu Gly Asp Gly Arg Ile Glu Thr Ile Glu Asp 
        115                 120                 125             


Ile Val Asn Ala Lys Glu Arg Asn Val Leu Ser Leu Asp Leu Asp Asn 
    130                 135                 140                 


Leu Ser Ile Lys Ile Asp Thr Ala Ile Lys Phe Trp Lys Leu Arg Tyr 
145                 150                 155                 160 


Asn Gly Asn Leu Ser Lys Ile Thr Leu Ser Asn Asn Tyr Glu Leu Lys 
                165                 170                 175     


Ala Thr Pro Asp His Cys Leu Leu Val Leu Arg Asp Asn Gln Leu Lys 
            180                 185                 190         


Trp Ile Pro Ala Lys Asp Ile Lys Glu Asn Asp Tyr Ile Ala Met Pro 
        195                 200                 205             


Phe Asn Tyr Lys Val Glu Arg Lys Pro Ile Ser Leu Leu Asn Leu Leu 
    210                 215                 220                 


Lys Tyr Leu Asp Ile Thr Asp Val Leu Ile Glu Phe Asp Glu Asn Ser 
225                 230                 235                 240 


Thr Ile Phe Glu Lys Ile Ala Glu Tyr Ile Arg Asn Asn Ile Lys Thr 
                245                 250                 255     


Ser Thr Lys Tyr Lys Tyr Leu Arg Asn Arg Arg Val Pro Leu Lys Tyr 
            260                 265                 270         


Leu Ile Glu Trp Asn Phe Asp Leu Asp Glu Ile Glu Lys Glu Ala Lys 
        275                 280                 285             


Tyr Ile Tyr Lys Ser Val Ala Gly Thr Lys Lys Ile Pro Leu Phe Lys 
    290                 295                 300                 


Leu Asp Glu Arg Phe Trp Tyr Phe Ala Gly Leu Val Leu Gly Asp Gly 
305                 310                 315                 320 


Ser Ile Gln Asp Ser Lys Ile Arg Ile Ala Gln Thr Pro Leu Lys Asp 
                325                 330                 335     


Val Lys Ser Ile Leu Asp Glu Thr Phe Pro Phe Leu His Asn Trp Ile 
            340                 345                 350         


Ser Gly Asn Gln Val Ile Ile Ser Asn Pro Ile Ile Ala Glu Ile Leu 
        355                 360                 365             


Glu Lys Leu Gly Met Arg Asn Gly Lys Leu Asn Gly Ile Ile Phe Ser 
    370                 375                 380                 


Leu Pro Glu Ser Tyr Ile Asn Ala Leu Ile Ala Gly Tyr Phe Asp Thr 
385                 390                 395                 400 


Asp Gly Cys Phe Ser Leu Leu Tyr Asp Lys Lys Ala Lys Lys His Asn 
                405                 410                 415     


Leu Arg Met Val Leu Thr Ser Lys Arg Arg Asp Val Leu Glu Lys Ile 
            420                 425                 430         


Gly Ile Tyr Leu Asn Ser Ile Gly Ile Leu Asn Thr Leu His Lys Ser 
        435                 440                 445             


Arg Glu Val Tyr Ser Leu Ile Ile Ser Asn Lys Ser Leu Glu Thr Phe 
    450                 455                 460                 


Lys Glu Lys Ile Ala Lys Tyr Leu Lys Ile Arg Lys Glu Ala Phe Ile 
465                 470                 475                 480 


Asn Gly Tyr Lys Thr Tyr Lys Lys Glu His Glu Glu Arg Phe Glu Cys 
                485                 490                 495     


Asp Leu Leu Pro Val Lys Glu Val Phe Lys Lys Leu Thr Phe Glu Lys 
            500                 505                 510         


Gly Arg Lys Glu Ile Leu Lys Asp Ser Lys Ile His Ile Glu Asn Trp 
        515                 520                 525             


Tyr Lys Glu Lys Thr Asn Asn Ile Pro Arg Glu Lys Leu Lys Thr Val 
    530                 535                 540                 


Leu Arg Tyr Ala Asn Asn Ser Glu His Lys Glu Phe Leu Glu Lys Ile 
545                 550                 555                 560 


Val Asn Gly Asp Ile Ser Phe Val Arg Val Lys Lys Val Glu Asn Ile 
                565                 570                 575     


Pro Tyr Asp Gly Tyr Val Tyr Asp Leu Ser Ile Lys His Asn Gln Asn 
            580                 585                 590         


Phe Ile Ser Asn Gly Val Ile Ser His Asn Ser Gly Val Lys Val Ala 
        595                 600                 605             


Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly 
    610                 615                 620                 


Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly 
625                 630                 635                 640 


His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile 
                645                 650                 655     


Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val 
            660                 665                 670         


Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu 
        675                 680                 685             


Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly 
    690                 695                 700                 


Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr 
705                 710                 715                 720 


Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly 
                725                 730                 735     


Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala 
            740                 745                 750         


Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly 
        755                 760                 765             


Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly 
    770                 775                 780                 


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
785                 790                 795                 800 


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
                805                 810                 815     


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
            820                 825                 830         


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840                 845             


<210>  195
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_RNR-1

<400>  195

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Leu Gly Arg 
            100                 105                 110         


Asp Glu Leu Ile Phe Ile Lys Glu Gly Asp Lys Leu Lys Val Cys Lys 
        115                 120                 125             


Ile Gly Glu Ala Ile Asp Glu Phe Met Glu Lys Tyr Lys Asp Lys Ile 
    130                 135                 140                 


Ile Val Asp Gly Asp Thr Glu Ile Leu Tyr Leu Asp Gly Ile Ala Glu 
145                 150                 155                 160 


Val Tyr Thr Ile Ser Val Asn Val Lys Thr Gly Lys Ala Glu Phe Lys 
                165                 170                 175     


Arg Val Tyr Ala Ile Ser Arg His Lys Pro Arg Gly Lys Val Tyr Lys 
            180                 185                 190         


Val Ile Gly Lys Asp Gly Thr Ser Ile Ile Val Thr Glu Asp His Ser 
        195                 200                 205             


Leu Phe Asn Tyr Asp Glu Asn Gly Asn Leu Val Cys Val Lys Pro Arg 
    210                 215                 220                 


Gln Met Lys His Ile Ile Arg Asn Phe Asn Asn Pro Tyr Asp Val Glu 
225                 230                 235                 240 


Tyr Arg Ile Gly Asp Tyr Ile Glu Thr Asn Tyr Gln Arg Thr Asp Ser 
                245                 250                 255     


Lys Tyr Asn Ser Arg Gln Asn Asp Ile Pro Glu Lys Leu Lys Ile Thr 
            260                 265                 270         


Lys Glu Leu Cys Gln Phe Leu Gly Leu Phe Val Ala Glu Gly Ser Tyr 
        275                 280                 285             


Ile Thr Asn Gly Ile Ser Ile Thr Thr Lys Asp Asp Asp Ile Ala Lys 
    290                 295                 300                 


Phe Ile Glu Arg Phe Val Lys Glu Gln Ile Asn Glu Asn Ile Ala Val 
305                 310                 315                 320 


Lys Arg Tyr Glu Asp Ser Val Arg Phe Val Asn Lys Gly Phe Tyr Arg 
                325                 330                 335     


Phe Leu Lys Glu His Ile Asn Gly Lys Ala Ile Asn Lys Asn Ser Pro 
            340                 345                 350         


Glu Phe Ile Leu Lys Gly Asp Lys Glu Met Lys Leu Ala Phe Leu Gly 
        355                 360                 365             


Gly Leu Ile Ser Gly Asp Gly Tyr Val Ser Lys Asp Gly Arg Val Gln 
    370                 375                 380                 


Ile Tyr Thr Thr Ser Glu Gln Leu Leu Gly Gln Leu His Leu Leu Leu 
385                 390                 395                 400 


Ser Asp Leu Gly Met Ile Tyr Ser Ile Thr Lys Ile Lys Glu Glu Gly 
                405                 410                 415     


Glu Lys Ile Glu Ile Lys Arg Asn Glu Ile Val Arg Asn Tyr Lys Leu 
            420                 425                 430         


Tyr Val Ile Glu Ile Ala Lys Asn Cys Thr Glu Asp Leu Lys Pro Tyr 
        435                 440                 445             


Val Ile Pro Lys Tyr Lys Lys Glu Arg Ile Lys Pro Ala Asn Tyr Asp 
    450                 455                 460                 


Gln Leu Pro Tyr Asp Tyr Arg Ile Ile Lys Glu His Leu Arg Lys Ile 
465                 470                 475                 480 


Thr Asp Lys Lys Pro Tyr Asn Asp Tyr Ala Trp Lys Ser Asn Asn Arg 
                485                 490                 495     


Lys Leu Lys Leu Asn Thr Leu Glu Lys Ile Glu Gln Leu Asn Pro His 
            500                 505                 510         


Leu Arg Glu Glu Ile Asn Lys Phe Lys Leu Asn Ile Pro Phe Glu Ile 
        515                 520                 525             


Lys Glu Ile Lys Glu Ile Asp Tyr Asn Gly Tyr Val Tyr Asp Leu Ser 
    530                 535                 540                 


Val Glu Asp Asn Glu Asn Phe Ile Thr Ala Thr Gly Ile Leu Cys His 
545                 550                 555                 560 


Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
                565                 570                 575     


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
            580                 585                 590         


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
        595                 600                 605             


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
    610                 615                 620                 


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
625                 630                 635                 640 


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
                645                 650                 655     


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
            660                 665                 670         


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
        675                 680                 685             


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
    690                 695                 700                 


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
705                 710                 715                 720 


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
                725                 730                 735     


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
            740                 745                 750         


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
        755                 760                 765             


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
    770                 775                 780                 


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
785                 790                 795                 800 


Asn Ala Glu Ala Ala Thr Arg 
                805         


<210>  196
<211>  887
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_RNR-2

<400>  196

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Leu Pro Tyr 
            100                 105                 110         


Asp Glu Lys Ile Leu Ile Phe Glu Asn Asn Glu Tyr Lys Leu Val Lys 
        115                 120                 125             


Ile Gly Glu Phe Val Glu Lys Tyr Leu Asn Arg Tyr Lys Asp Arg Ala 
    130                 135                 140                 


Ile Thr Tyr Gly Asp Asn Asn Ile Glu Val Tyr Ile Lys Asp Glu Asn 
145                 150                 155                 160 


Ile Tyr Ala Pro Ser Phe Asp Lys Asp Gly Lys Ile Val Leu Lys Pro 
                165                 170                 175     


Ile Thr His Ala Ile Arg His Arg Gly Lys Glu Ile Tyr Glu Ile Glu 
            180                 185                 190         


Leu Glu Ser Gly Lys Lys Val Arg Val Thr Gly Asp His Ser Val Phe 
        195                 200                 205             


Thr Ile Asn Asp Asn Leu Asp Val Val Glu Val Lys Ala Ser Asp Leu 
    210                 215                 220                 


Lys Val Gly Asp Phe Ile Ile Thr Pro Lys Ile Ile Pro Ser Ile Ser 
225                 230                 235                 240 


Lys Asp Lys Ile Tyr Leu Ser Glu Ile Val Lys Asn Lys Asp Lys Tyr 
                245                 250                 255     


Tyr Val Lys Ile Lys Asp His Ile Lys Phe Ile Glu Glu His Glu Glu 
            260                 265                 270         


Ile Leu Lys Glu Ser Tyr Lys Glu Tyr Lys Thr Lys Trp Lys Asp Leu 
        275                 280                 285             


Lys Pro Val Leu Lys Lys Lys Asn Ala Phe Arg Leu Asp Leu Ile Glu 
    290                 295                 300                 


Asp Leu Val Asp Lys Glu Lys Ile Glu Lys Ile Ser Tyr Gly His Ala 
305                 310                 315                 320 


Asn Tyr Ile Asn Asn Lys Ile Lys Leu Asp Glu Lys Phe Gly Tyr Leu 
                325                 330                 335     


Ile Gly Ala Phe Leu Ser Glu Gly His Trp Asn Asp Lys Cys Val Glu 
            340                 345                 350         


Ile Ser Ser Thr Asn Lys Glu Phe Ile Glu Asn Leu Val Glu Ile Ile 
        355                 360                 365             


Glu Glu Ile Leu Gly Lys Asp Ala Tyr Tyr Ile Thr Val Lys Gly Asp 
    370                 375                 380                 


Lys Arg Arg Tyr Lys Asp Leu Tyr Val Ile Gly Leu Asn Lys Thr Val 
385                 390                 395                 400 


Ala Met Ile Phe Glu Ser Leu Gly Leu Asn Lys Leu Ser Ser Asn Lys 
                405                 410                 415     


Glu Ile Pro Ser Ile Leu Leu Ser Asn Glu Thr Phe Leu Lys Gly Leu 
            420                 425                 430         


Ile Lys Gly Tyr Ile Asp Gly Asp Gly Ser Ile Tyr Val Asp Glu Ser 
        435                 440                 445             


Lys Arg Asp Tyr Ser Ile Arg Leu Tyr Thr Thr Ser Glu Thr Leu Arg 
    450                 455                 460                 


Asp Thr Leu Cys Leu Ala Leu Lys Ile Leu Gly Ile Asn Tyr Arg Leu 
465                 470                 475                 480 


Ser Ile Asp Lys Lys Ser Lys Val Asn Glu Asn Trp Arg Asp Cys Tyr 
                485                 490                 495     


Val Ile Lys Ile Thr Gly Lys Glu Asn Ile Glu Lys Leu Leu Asp Val 
            500                 505                 510         


Glu Ile Lys Asn Asn Gly Gly Lys Asp Val Ile Pro Lys Ile Ala Glu 
        515                 520                 525             


Lys Phe Lys Glu Ile Ile Asn Gln Tyr Ser Gln Arg Glu Trp Lys Glu 
    530                 535                 540                 


Arg Phe Gly Ile Asp Val Asn Asn Leu His Ile Trp Glu Asp Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Met Ser Arg Tyr Arg Ala Lys Lys Val Leu Asn Ile Met 
                565                 570                 575     


Lys Asn Val Lys Glu Ile Glu Glu Lys Tyr Gly Arg Leu Leu Asp Lys 
            580                 585                 590         


Ile Gly Gln Leu Ile Asp Asn Asp Leu Leu Phe Glu Arg Ile Lys Ser 
        595                 600                 605             


Ile Arg Val Leu Asp Glu Ile Pro Glu Tyr Val Tyr Asp Ile Ser Val 
    610                 615                 620                 


Glu Gly Thr Glu Asn Phe Ile Gly Gly Glu Gly Phe Ile Cys Leu His 
625                 630                 635                 640 


Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
                645                 650                 655     


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
            660                 665                 670         


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
        675                 680                 685             


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
    690                 695                 700                 


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
705                 710                 715                 720 


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
                725                 730                 735     


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
            740                 745                 750         


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
        755                 760                 765             


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
    770                 775                 780                 


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
785                 790                 795                 800 


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
                805                 810                 815     


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
            820                 825                 830         


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
        835                 840                 845             


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
    850                 855                 860                 


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
865                 870                 875                 880 


Asn Ala Glu Ala Ala Thr Arg 
                885         


<210>  197
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_rPol_Ap

<400>  197

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Asp Gly 
            100                 105                 110         


Asp Thr Thr Val Leu Leu Asp Gly Lys Leu Ile Lys Ile Lys Asp Leu 
        115                 120                 125             


Glu Asp Lys Trp Lys Asp Val Lys Val Leu Thr Ser Asp Asp Leu Asn 
    130                 135                 140                 


Pro Lys Leu Thr Ser Leu Ser Lys Tyr Trp Lys Leu Asn Ala Asp Glu 
145                 150                 155                 160 


Tyr Gly Lys Lys Ile Tyr Lys Ile Lys Thr Glu Leu Gly Arg Glu Ile 
                165                 170                 175     


Ile Ala Thr Glu Asp His Pro Phe Tyr Thr Thr Asn Gly Arg Lys Arg 
            180                 185                 190         


Cys Gly Glu Leu Lys Val Gly Asp Glu Val Ile Ile Tyr Pro Asn Asp 
        195                 200                 205             


Phe Pro Met Phe Glu Asp Asp Asn Arg Val Ile Val Asp Glu Glu Lys 
    210                 215                 220                 


Ile Lys Lys Val Ile Asn Asn Ile Gly Gly Thr Tyr Lys Asn Lys Ile 
225                 230                 235                 240 


Ile Asn Glu Leu Lys Asp Arg Lys Leu Ile Pro Leu Thr Tyr Asn Asp 
                245                 250                 255     


Gln Lys Ala Ser Ile Leu Ala Arg Ile Val Gly His Val Met Gly Asp 
            260                 265                 270         


Gly Ser Leu Ile Ile Asn Asn Lys Asn Ser Arg Val Val Phe Arg Gly 
        275                 280                 285             


Asp Ile Glu Asp Leu Lys Thr Ile Lys Glu Asp Leu Lys Glu Leu Gly 
    290                 295                 300                 


Tyr Asp Gly Glu Glu Ile Lys Leu His Glu Gly Glu Thr Glu Ile Thr 
305                 310                 315                 320 


Asp Tyr Asn Gly Lys Lys Arg Ile Ile Lys Gly Lys Gly Tyr Ser Phe 
                325                 330                 335     


Glu Val Arg Lys Lys Ser Leu Cys Ile Leu Leu Lys Ala Leu Gly Cys 
            340                 345                 350         


Val Gly Gly Asp Lys Thr Lys Lys Met Tyr Gly Ile Pro Asn Trp Ile 
        355                 360                 365             


Lys Thr Ala Pro Lys Tyr Ile Lys Lys Glu Phe Leu Ser Ala Tyr Phe 
    370                 375                 380                 


Gly Ser Glu Leu Thr Thr Pro Lys Ile Arg Asn His Gly Thr Ser Phe 
385                 390                 395                 400 


Lys Glu Leu Ser Phe Lys Ile Ala Lys Ile Glu Glu Ile Phe Asp Glu 
                405                 410                 415     


Asp Arg Phe Ile Lys Asp Ile Lys Glu Met Leu Lys Glu Phe Gly Ile 
            420                 425                 430         


Glu Leu Lys Val Arg Val Glu Glu Gly Asn Leu Arg Lys Asp Gly Tyr 
        435                 440                 445             


Lys Thr Lys Val Tyr Val Ala Ser Ile Tyr Asn His Lys Glu Phe Phe 
    450                 455                 460                 


Gly Arg Ile Gly Tyr Thr Tyr Ala Asn Lys Lys Glu Thr Leu Ala Arg 
465                 470                 475                 480 


Tyr Ala Tyr Glu Tyr Leu Leu Thr Lys Glu Lys Tyr Leu Lys Asp Arg 
                485                 490                 495     


Asn Ile Lys Lys Leu Glu Asn Asn Thr Lys Phe Ile Thr Phe Asp Lys 
            500                 505                 510         


Phe Ile Lys Glu Lys Cys Leu Lys Asn Gly Phe Val Lys Glu Lys Ile 
        515                 520                 525             


Val Ser Ile Glu Glu Thr Lys Val Asp Tyr Val Tyr Asp Ile Thr Thr 
    530                 535                 540                 


Ile Ser Glu Thr His Asn Phe Ile Ala Asn Gly Phe Leu Thr Gly Asn 
545                 550                 555                 560 


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
                565                 570                 575     


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
            580                 585                 590         


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
        595                 600                 605             


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
    610                 615                 620                 


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
625                 630                 635                 640 


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
                645                 650                 655     


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
            660                 665                 670         


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
        675                 680                 685             


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
    690                 695                 700                 


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
705                 710                 715                 720 


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
                725                 730                 735     


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
            740                 745                 750         


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
        755                 760                 765             


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
    770                 775                 780                 


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
785                 790                 795                 800 


Ala Glu Ala Ala Thr Arg 
                805     


<210>  198
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_rPol_App

<400>  198

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Leu Pro Tyr 
            100                 105                 110         


Glu Glu Lys Ile Ile Ile Lys Glu Gly Glu Phe Ile Lys Pro Val Glu 
        115                 120                 125             


Ile Gly Lys Leu Val Asp Glu Met Ile Glu Arg Phe Gly Phe Glu Lys 
    130                 135                 140                 


Ile Gly Asn Ser Glu Val Cys Asp Leu Pro Ile Asp Ile Tyr Ala Leu 
145                 150                 155                 160 


Ser Leu Asp Gln Asp Glu Lys Val His Trp Lys Arg Ile Ile Ser Cys 
                165                 170                 175     


Ile Arg His Lys His Asn Gly Lys Leu Ile Lys Ile Lys Thr Lys Ser 
            180                 185                 190         


Gly Arg Glu Ile Thr Ala Thr Pro Tyr His Ser Phe Val Ile Arg Lys 
        195                 200                 205             


Asp Asn Lys Ile Ile Pro Val Lys Gly Ser Glu Leu Lys Ile Gly Asp 
    210                 215                 220                 


Arg Ile Pro Val Val Lys His Ile Pro Ala Asn Cys Val Glu Ala Ile 
225                 230                 235                 240 


Asn Ile Ser Asp Tyr Val Ser Gly Asn Tyr Val Val Asp Asn Ile Asn 
                245                 250                 255     


Asn Lys Ile Ala Pro Lys Ile Asn Gly Lys Ser Ile Pro Asn Asn Ile 
            260                 265                 270         


Lys Leu Asp Tyr Asp Phe Gly Tyr Phe Ile Gly Ile Tyr Leu Ala Glu 
        275                 280                 285             


Gly Ser Val Thr Lys Tyr Phe Val Ser Ile Ser Asn Val Asp Glu Leu 
    290                 295                 300                 


Ile Leu Asn Lys Ile Arg Ala Phe Ala Asp Lys Leu Gly Leu Asn Tyr 
305                 310                 315                 320 


Gly Glu Tyr Asp Asn Asn Asn Gly Phe Ala Glu Ser His Asp Ile Arg 
                325                 330                 335     


Ile Tyr Ser Ser Thr Leu Ala Glu Phe Leu Ser Asn Phe Gly Thr Ser 
            340                 345                 350         


Ser Asn Thr Lys Lys Ile Ala Glu Phe Val Phe Gly Ala Asn Lys Glu 
        355                 360                 365             


Phe Val Arg Gly Leu Ile Arg Gly Tyr Phe Asp Gly Asp Gly Asn Val 
    370                 375                 380                 


Asn Ala Asp Arg Lys Val Ile Arg Val Thr Ser Asn Ser Lys Glu Leu 
385                 390                 395                 400 


Ile Asp Gly Ile Ala Ile Leu Leu Ala Arg Phe Asn Ile Phe Ser Ile 
                405                 410                 415     


Lys Thr Lys Thr Lys Asn Gln Phe Val Leu Ile Ile Pro His Arg Tyr 
            420                 425                 430         


Ala Lys Lys Phe His Glu Glu Ile Asn Phe Ser Val Glu Lys Lys Lys 
        435                 440                 445             


Ser Glu Leu Glu Arg Leu Val Ser Ser Leu Asn Asp Asp Lys Thr Tyr 
    450                 455                 460                 


Asp Ser Ile Asp Met Ile Pro Ser Ile Gly Asp Ala Leu Thr Lys Leu 
465                 470                 475                 480 


Gly Glu Lys Val Asp Tyr Pro Lys Val Ile Leu Lys Lys Phe Glu Arg 
                485                 490                 495     


Lys Gln Lys Ile Gly Arg Ala Thr Leu Gln Arg His Leu Arg Arg Ile 
            500                 505                 510         


Glu Glu Leu Ala Val Lys Lys Gly Val Asn Ile Leu Ala Leu Lys Glu 
        515                 520                 525             


Tyr Trp Leu Leu Lys Lys Ala Val Glu Ser Asp Val Ile Trp Asp Glu 
    530                 535                 540                 


Ile Val Lys Ile Glu Glu Ile Ser Cys Asp Lys Lys Tyr Val Tyr Asp 
545                 550                 555                 560 


Ile Ser Val Glu Gly Leu Glu Thr Phe Thr Thr Phe Asp Gly Val Leu 
                565                 570                 575     


Thr His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser 
            580                 585                 590         


Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly 
        595                 600                 605             


Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly 
    610                 615                 620                 


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro 
625                 630                 635                 640 


Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly 
                645                 650                 655     


Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly 
            660                 665                 670         


Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr 
        675                 680                 685             


Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val 
    690                 695                 700                 


Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg 
705                 710                 715                 720 


Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg 
                725                 730                 735     


Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly 
            740                 745                 750         


Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn 
        755                 760                 765             


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
    770                 775                 780                 


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
785                 790                 795                 800 


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
                805                 810                 815     


Leu Val Asn Ala Glu Ala Ala Thr Arg 
            820                 825 


<210>  199
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Mja_RtcB_Mja_Hyp-2

<400>  199

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Ser 
            100                 105                 110         


Asn Ser Lys Ile Leu Thr Asp Asp Gly Tyr Tyr Ile Lys Leu Glu Lys 
        115                 120                 125             


Leu Lys Glu Lys Leu Asp Leu His Ile Lys Ile Tyr Asn Thr Glu Glu 
    130                 135                 140                 


Gly Glu Lys Ser Ser Asn Ile Leu Phe Val Ser Glu Arg Tyr Ala Asp 
145                 150                 155                 160 


Glu Lys Ile Ile Arg Ile Lys Thr Glu Ser Gly Arg Val Leu Glu Gly 
                165                 170                 175     


Ser Lys Asp His Pro Val Leu Thr Leu Asn Gly Tyr Val Pro Met Gly 
            180                 185                 190         


Met Leu Lys Glu Gly Asp Asp Val Ile Val Tyr Pro Tyr Glu Gly Val 
        195                 200                 205             


Glu Tyr Glu Glu Pro Ser Asp Glu Ile Ile Leu Asp Glu Asp Asp Phe 
    210                 215                 220                 


Ala Glu Tyr Asp Lys Gln Ile Ile Lys Tyr Leu Lys Asp Arg Gly Leu 
225                 230                 235                 240 


Leu Pro Leu Arg Met Asp Asn Lys Asn Ile Gly Ile Ile Ala Arg Leu 
                245                 250                 255     


Leu Gly Phe Ala Phe Gly Asp Gly Ser Ile Val Lys Glu Asn Gly Asp 
            260                 265                 270         


Arg Glu Arg Leu Tyr Val Ala Phe Tyr Gly Lys Arg Glu Thr Leu Ile 
        275                 280                 285             


Lys Ile Arg Glu Asp Leu Glu Lys Leu Gly Ile Lys Ala Ser Arg Ile 
    290                 295                 300                 


Tyr Ser Arg Lys Arg Glu Val Glu Ile Arg Asn Ala Tyr Gly Asp Glu 
305                 310                 315                 320 


Tyr Thr Ser Leu Cys Glu Asp Asn Ser Ile Lys Ile Thr Ser Lys Ala 
                325                 330                 335     


Phe Ala Leu Phe Met His Lys Leu Gly Met Pro Ile Gly Lys Lys Thr 
            340                 345                 350         


Glu Gln Ile Tyr Lys Ile Pro Glu Trp Ile Lys Lys Ala Pro Lys Trp 
        355                 360                 365             


Val Lys Arg Asn Phe Leu Ala Gly Leu Phe Gly Ala Asp Gly Ser Arg 
    370                 375                 380                 


Ala Val Phe Lys Asn Tyr Thr Pro Leu Pro Ile Asn Leu Thr Met Ser 
385                 390                 395                 400 


Lys Ser Glu Glu Leu Lys Glu Asn Ile Leu Glu Phe Leu Asn Glu Ile 
                405                 410                 415     


Lys Leu Leu Leu Ala Glu Phe Asp Ile Glu Ser Met Ile Tyr Glu Ile 
            420                 425                 430         


Lys Ser Leu Asp Gly Arg Val Ser Tyr Arg Leu Ala Ile Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Lys Asn Phe Leu Gly Arg Ile Asn Tyr Glu Tyr Ser Gly 
    450                 455                 460                 


Glu Lys Lys Val Ile Gly Leu Leu Ala Tyr Glu Tyr Leu Arg Arg Lys 
465                 470                 475                 480 


Asp Ile Ala Lys Glu Ile Arg Lys Lys Cys Ile Lys Arg Ala Lys Glu 
                485                 490                 495     


Leu Tyr Lys Lys Gly Val Thr Val Ser Glu Met Leu Lys Met Asp Glu 
            500                 505                 510         


Phe Arg Asn Glu Phe Ile Ser Lys Arg Leu Ile Glu Arg Ala Val Tyr 
        515                 520                 525             


Glu Asn Leu Asp Glu Asp Asp Val Arg Ile Ser Thr Lys Phe Pro Lys 
    530                 535                 540                 


Phe Glu Glu Phe Ile Glu Lys Tyr Gly Val Ile Gly Gly Phe Val Ile 
545                 550                 555                 560 


Asp Lys Ile Lys Glu Ile Glu Glu Ile Ser Tyr Asp Ser Lys Leu Tyr 
                565                 570                 575     


Asp Val Gly Ile Val Ser Lys Glu His Asn Phe Ile Ala Asn Ser Ile 
            580                 585                 590         


Val Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
        595                 600                 605             


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
    610                 615                 620                 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
625                 630                 635                 640 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
                645                 650                 655     


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
            660                 665                 670         


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
        675                 680                 685             


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
    690                 695                 700                 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
705                 710                 715                 720 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
                725                 730                 735     


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
            740                 745                 750         


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
        755                 760                 765             


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
    770                 775                 780                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
785                 790                 795                 800 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                805                 810                 815     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            820                 825                 830         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840         


<210>  200
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_TFIIB

<400>  200

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Val Asp Tyr 
            100                 105                 110         


Asn Glu Pro Ile Ile Ile Lys Glu Asn Gly Glu Ile Lys Val Val Lys 
        115                 120                 125             


Ile Gly Glu Leu Ile Asp Lys Ile Ile Glu Asn Ser Glu Asn Ile Arg 
    130                 135                 140                 


Arg Glu Gly Ile Leu Glu Ile Ala Lys Cys Lys Gly Ile Glu Val Ile 
145                 150                 155                 160 


Ala Phe Asn Ser Asn Tyr Lys Phe Lys Phe Met Pro Val Ser Glu Val 
                165                 170                 175     


Ser Arg His Pro Val Ser Glu Met Phe Glu Ile Val Val Glu Gly Asn 
            180                 185                 190         


Lys Lys Val Arg Val Thr Arg Ser His Ser Val Phe Thr Ile Arg Asp 
        195                 200                 205             


Asn Glu Val Val Pro Ile Arg Val Asp Glu Leu Lys Val Gly Asp Ile 
    210                 215                 220                 


Leu Val Leu Ala Lys Glu Leu Pro Asn Ile Glu Glu Asp Ile Glu Ile 
225                 230                 235                 240 


Asp Lys Lys Phe Ser Lys Ile Leu Gly Tyr Ile Ile Ala Glu Gly Tyr 
                245                 250                 255     


Tyr Asp Asp Lys Lys Ile Val Leu Ser Tyr Asp Tyr Asn Glu Lys Glu 
            260                 265                 270         


Phe Ile Asn Glu Thr Ile Asp Tyr Phe Lys Ser Leu Asn Ser Asp Ile 
        275                 280                 285             


Thr Ile Tyr Ser Lys Asp Leu Asn Ile Gln Ile Glu Val Lys Asn Lys 
    290                 295                 300                 


Lys Ile Ile Asn Leu Leu Lys Lys Leu Arg Val Lys Asn Lys Arg Ile 
305                 310                 315                 320 


Pro Ser Ile Ile Phe Lys Ser Pro Tyr Glu Ile Lys Lys Ser Phe Ile 
                325                 330                 335     


Asp Gly Ile Phe Asn Gly Lys Asp Ala Lys Val Phe Val Ser Lys Glu 
            340                 345                 350         


Leu Ala Glu Asp Val Ile Phe Leu Leu Leu Gln Ile Lys Glu Asn Ala 
        355                 360                 365             


Thr Ile Asn Lys Lys Ser Ile Asn Asp Ile Glu Val Tyr Glu Val Arg 
    370                 375                 380                 


Arg Ile Thr Asn Ile Tyr Thr Asn Arg Lys Leu Glu Lys Leu Ile Asn 
385                 390                 395                 400 


Ser Asp Phe Ile Phe Leu Lys Ile Lys Glu Ile Asn Lys Val Glu Pro 
                405                 410                 415     


Thr Ser Gly Tyr Ala Tyr Asp Leu Thr Val Pro Asn Ala Glu Asn Phe 
            420                 425                 430         


Val Ala Gly Phe Gly Gly Phe Val Leu His Asn Ser Gly Val Lys Val 
        435                 440                 445             


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
    450                 455                 460                 


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
465                 470                 475                 480 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
                485                 490                 495     


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
            500                 505                 510         


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
        515                 520                 525             


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
    530                 535                 540                 


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
545                 550                 555                 560 


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
                565                 570                 575     


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
            580                 585                 590         


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
        595                 600                 605             


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
    610                 615                 620                 


Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
625                 630                 635                 640 


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
                645                 650                 655     


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
            660                 665                 670         


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
        675                 680                 685             


Arg 
    


<210>  201
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_UDP_GD

<400>  201

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe His Pro 
            100                 105                 110         


Asp Glu Val Leu Phe Ile Asp Arg Gly Arg Gly Leu Glu Cys Ile Thr 
        115                 120                 125             


Phe Lys Glu Leu Phe Glu Leu Glu Asp Lys Asp Asn Val Lys Ile Leu 
    130                 135                 140                 


Ser Phe Asp Gly Glu Lys Leu Ser Leu Lys Lys Leu Lys Leu Ala Ser 
145                 150                 155                 160 


Lys Arg Tyr Tyr Asn Asp Asp Leu Ile Thr Leu Arg Phe Asn Leu Gly 
                165                 170                 175     


Arg Glu Ile Lys Ile Thr Lys Asp His Pro Val Val Ile Leu Glu Asp 
            180                 185                 190         


Gly Glu Leu Lys Ile Lys Leu Thr Ser Asp Val Lys Glu Gly Asp Lys 
        195                 200                 205             


Val Ile Leu Pro Tyr Gly Asn Phe Gly Glu Glu Arg Glu Ile Glu Ile 
    210                 215                 220                 


Asp Ile Leu Glu Glu Leu Ser Lys Thr Asp Leu Ile Glu Lys Val Trp 
225                 230                 235                 240 


Ile His Asn Lys Asp Leu Ala Thr Asn Glu Phe Asn Ile Ile Lys Pro 
                245                 250                 255     


Tyr Leu Ser Asn Lys Tyr Pro His Asp Val Lys Arg Asn Gly Thr Ile 
            260                 265                 270         


Arg Ala Lys Asp Ile Leu Pro Ile Lys Glu Ile Leu Asp Lys Tyr Gly 
        275                 280                 285             


Ser Lys Asn Arg Leu Phe Thr Ala Lys Ser Lys Ser Thr Thr Ile Pro 
    290                 295                 300                 


Tyr Lys Ile Lys Ile Asp Lys Asp Phe Ala Arg Leu Ile Gly Tyr Tyr 
305                 310                 315                 320 


Leu Ser Glu Gly Trp Ile Ser Lys Asp Tyr Gly Arg Asn Gly Val Val 
                325                 330                 335     


Arg Lys Arg Ile Gly Leu Cys Phe Gly Ile His Glu Glu Glu Tyr Ile 
            340                 345                 350         


Asn Asp Val Lys Asn Ile Leu Asn Lys Leu Gly Ile Lys Tyr Ile Glu 
        355                 360                 365             


Lys Ile Lys Asp Gly Ser His Ser Ile Leu Ile Ser Ser Lys Ile Leu 
    370                 375                 380                 


Ala Tyr Val Phe Glu Asn Ile Leu Asn Cys Gly Ile Asn Cys Tyr Asn 
385                 390                 395                 400 


Lys Asn Ile Pro Pro Gln Met Phe Asn Ala Lys Glu Glu Ile Lys Trp 
                405                 410                 415     


Glu Phe Leu Lys Gly Leu Phe Arg Gly Asp Gly Gly Ile Val Arg Leu 
            420                 425                 430         


Asn Asn Asn Lys Asn Leu Asn Ile Glu Phe Ala Thr Val Ser Lys Lys 
        435                 440                 445             


Met Ala His Ser Leu Leu Ile Leu Leu Gln Leu Leu Gly Ile Val Ala 
    450                 455                 460                 


Ser Val Lys Lys Cys Tyr Asn Asn Lys Ser Thr Thr Met Ala Tyr Ile 
465                 470                 475                 480 


Ile Arg Ile Asn Gly Leu Glu Gln Val Lys Lys Ile Gly Glu Leu Phe 
                485                 490                 495     


Gly Lys Lys Trp Glu Asn Tyr Lys Asp Ile Ala Glu Ser Tyr Lys Arg 
            500                 505                 510         


Asn Ile Glu Pro Leu Gly Tyr Lys Lys Ser Asp Asn Phe Ala Ile Leu 
        515                 520                 525             


Glu Val Lys Glu Ile Ile Lys Glu His Tyr Ser Gly Tyr Val Tyr Ser 
    530                 535                 540                 


Val Glu Thr Glu Asn Ser Leu Leu Ile Thr Ser Tyr Gly Ile Leu Ile 
545                 550                 555                 560 


His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
                565                 570                 575     


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
            580                 585                 590         


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
        595                 600                 605             


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
    610                 615                 620                 


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
625                 630                 635                 640 


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
                645                 650                 655     


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
            660                 665                 670         


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
        675                 680                 685             


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
    690                 695                 700                 


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
705                 710                 715                 720 


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
                725                 730                 735     


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
            740                 745                 750         


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
        755                 760                 765             


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
    770                 775                 780                 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
785                 790                 795                 800 


Val Asn Ala Glu Ala Ala Thr Arg 
                805             


<210>  202
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mka_CDC48

<400>  202

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Ile Pro Gly 
            100                 105                 110         


Asp Glu Val Val Trp Ala Lys Val Asp Gly Glu Ala Lys Leu Ile Pro 
        115                 120                 125             


Ile Glu Asp Leu Tyr Glu Leu Trp Lys Glu Gly Arg Asp Val Glu Val 
    130                 135                 140                 


Ala Ala Leu Thr Glu Glu Gly Val Val Trp Ser Ser Val Asp Arg Val 
145                 150                 155                 160 


Ala Arg His Arg Arg Arg Thr Gly Leu Val Lys Ile Ile Thr Arg Thr 
                165                 170                 175     


Gly Arg Glu Val Ile Val Thr Glu Asp His Ser Val Phe Thr Val Arg 
            180                 185                 190         


Asp Gly Lys Ile Val Asp Val Pro Thr Ser Glu Leu Ser Glu Gly Asp 
        195                 200                 205             


Trp Ile Val Leu Pro Ala Arg Leu Pro Ala Gly Asp Ser Asp Glu Ile 
    210                 215                 220                 


Asp Gly Ile Lys Ile Asp Glu Asp Leu Ala Phe Leu Leu Gly Leu Tyr 
225                 230                 235                 240 


Val Ala Glu Gly Ser Leu Thr Asn Gln Lys Asp Ala Val Arg Ile His 
                245                 250                 255     


Asn Lys Asp Pro Glu Val Ile Glu Glu Ile Asp Arg Ile Val Arg Glu 
            260                 265                 270         


Lys Gly Trp Glu Gly Arg Tyr Tyr Glu Ser Asp His Ser Tyr Trp Ile 
        275                 280                 285             


Lys Ser Arg Lys Leu Arg Gln Leu Cys Glu Lys Leu Gly Thr Lys Ala 
    290                 295                 300                 


Arg Glu Lys Arg Leu Gly Pro Leu Leu Ser Leu Lys Pro Glu Leu Leu 
305                 310                 315                 320 


Ala Ala Ala Leu Arg Gly Tyr Tyr Thr Gly Asp Gly Ser Phe Ser Val 
                325                 330                 335     


Lys Pro His Gly Arg Ser Ala Ile Ile Glu Ala Thr Thr Val Ser Lys 
            340                 345                 350         


Arg Leu Ala Asp Glu Leu Leu Val Ala Leu Gln Ile Leu Asp Ile Val 
        355                 360                 365             


Ala Arg Arg Tyr Glu Cys Asp Asp Thr Lys Gly Ser Thr Arg Tyr Arg 
    370                 375                 380                 


Val Met Ile Thr Lys Ser Glu Tyr Ile Arg Thr Phe Val Glu Lys Val 
385                 390                 395                 400 


Gly Phe Ala Gln Ser Glu Lys Asn Glu Arg Ile Arg Lys Phe Leu Ala 
                405                 410                 415     


Glu Arg Lys Trp Thr Arg Gly Arg Ser Asp Ile Pro Thr Glu Leu Ile 
            420                 425                 430         


Gly Ser Pro Tyr Thr Tyr Val Glu Val Glu Tyr Ile Ser Asp Arg Val 
        435                 440                 445             


Ala Ala Asp Gly Gly Leu Met Lys Ala Glu Leu Glu His Leu Tyr Phe 
    450                 455                 460                 


Asp Lys Ile Lys Glu Ile Val Pro Leu Asp Arg Asp Asp Glu Tyr Val 
465                 470                 475                 480 


Tyr Asp Val Val Glu Val Lys Leu Gly His Asn Phe Val Gly Gly Gln 
                485                 490                 495     


Gly Val Leu Leu His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
            500                 505                 510         


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
        515                 520                 525             


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
    530                 535                 540                 


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
545                 550                 555                 560 


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
                565                 570                 575     


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
            580                 585                 590         


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
        595                 600                 605             


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
    610                 615                 620                 


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
625                 630                 635                 640 


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
                645                 650                 655     


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
            660                 665                 670         


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
        675                 680                 685             


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
    690                 695                 700                 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
705                 710                 715                 720 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
                725                 730                 735     


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            740                 745             


<210>  203
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mka_EF2

<400>  203

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ala Pro 
            100                 105                 110         


Glu Thr Lys Ile Cys Leu Ala Asp Gly Arg Phe Val Arg Ala Asp Glu 
        115                 120                 125             


Leu Phe Glu Glu Leu Lys Glu Arg Gly Arg Leu Val Lys Cys Asp Glu 
    130                 135                 140                 


Ser Glu Glu Val Tyr Glu Leu Arg Glu Pro Val Gly Val Ser Ser Leu 
145                 150                 155                 160 


Asp Lys Asp Ala Val Glu Ile Val Glu Gly Lys Ile Thr His Val Trp 
                165                 170                 175     


Arg Leu Lys Ala Asp Lys Leu Val Glu Val Glu Val Lys Asn Gly Arg 
            180                 185                 190         


Ser Ile Arg Thr Thr Pro Glu His Lys Phe Leu Val Leu Asp Pro Ser 
        195                 200                 205             


Gly Glu Ile Val Glu Lys Arg Ala Asp Glu Leu Glu Ile Gly Asp Tyr 
    210                 215                 220                 


Ile Val Cys Thr Gln Lys Leu Val His Glu Gly Met Ser Glu Glu Glu 
225                 230                 235                 240 


Leu Lys Arg Glu Val Phe Arg Arg Leu Gly Arg Asp Phe Phe Val His 
                245                 250                 255     


Leu Pro Glu Glu Glu Ala Glu Ser Val Leu Glu Leu Ala Lys Glu Arg 
            260                 265                 270         


Gly Ile Lys Ala Leu Trp Glu Thr Leu Glu Val Asp Ile Glu Glu Asn 
        275                 280                 285             


Ser Phe Tyr Tyr Gln Leu Arg Lys Gly Arg Ile Arg Ala Asp Ile Leu 
    290                 295                 300                 


Val Asp Leu Ala Glu Glu Leu Gly Leu Asp Leu Ala Asp Leu Tyr Asp 
305                 310                 315                 320 


Ala Val Glu Val Ser Tyr Arg Ser Asn Thr Lys Ser Thr Lys Pro Ile 
                325                 330                 335     


Arg Leu Pro Glu Pro Glu Asp Leu Phe Tyr Leu Ala Gly Leu Met Phe 
            340                 345                 350         


Gly Asp Gly Cys Trp Asn Gln Leu Thr Asn Gly Ser Glu Ala Ile Gln 
        355                 360                 365             


Gly Glu Val Lys Arg Ile Ala Ser Asp Met Gly Leu Glu Val Arg Val 
    370                 375                 380                 


Arg Arg Tyr Glu Gly Lys Thr Ala Arg Ile Asp Phe Pro Glu Thr Val 
385                 390                 395                 400 


Pro Arg Ile Leu Glu Ala Leu Phe Asp Tyr Pro Arg Arg Lys Lys Ala 
                405                 410                 415     


His Arg Ile Arg Val Asn Asp Phe Leu Thr Arg Ala Pro Leu Asp Cys 
            420                 425                 430         


Ile Ala Glu Phe Ile Arg Gly Tyr Phe Asp Ala Asp Gly Thr Val Glu 
        435                 440                 445             


Glu Gly Arg Ser Ala Val Ser Val Thr Ser Val Ser Arg Glu Phe Leu 
    450                 455                 460                 


Glu Asp Leu Gln Leu Leu Leu Gln Lys Phe Asp Val Ala Ser Tyr Leu 
465                 470                 475                 480 


Arg Glu Gly Asp Gly Ala Tyr Thr Leu Tyr Val Ser Gly Ala Arg Ser 
                485                 490                 495     


Leu Glu Arg Phe Pro Gly Phe Arg Glu Pro Glu Lys Ala Glu Lys Leu 
            500                 505                 510         


Lys Lys Leu Met Glu Lys Ala Ser Ser Ser Glu Leu Glu Lys Val Pro 
        515                 520                 525             


Ile Ser Gly Glu Ile Leu Arg Glu Val Arg Gly Asp Val Pro Thr Thr 
    530                 535                 540                 


Arg Met Phe Asn Cys Tyr Ser Asn Tyr Glu Gly Gly Gln Val Gly Leu 
545                 550                 555                 560 


Thr Lys Ser Ser Leu Glu Lys Val Ile Ser Thr Leu Glu Ala Val Gly 
                565                 570                 575     


Val Glu Gly Glu Ala Leu Glu Arg Leu Lys Ala Leu Ala Arg Asp Asp 
            580                 585                 590         


Val Cys Phe Leu Glu Val Val Arg Val Glu Glu Val Glu Tyr Asp Gly 
        595                 600                 605             


Tyr Val Tyr Asp Phe Thr Val Glu Glu His His Asn Phe Ala Ala Glu 
    610                 615                 620                 


Gly Phe Val Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
625                 630                 635                 640 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
                645                 650                 655     


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
            660                 665                 670         


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
        675                 680                 685             


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
    690                 695                 700                 


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
705                 710                 715                 720 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
                725                 730                 735     


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
            740                 745                 750         


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
        755                 760                 765             


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
    770                 775                 780                 


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
785                 790                 795                 800 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
                805                 810                 815     


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
            820                 825                 830         


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
        835                 840                 845             


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
    850                 855                 860                 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
865                 870                 875     


<210>  204
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mka_RFC

<400>  204

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Val Ser Ala 
            100                 105                 110         


Asp Thr Pro Ile Leu Val Arg Arg Gly Gly Glu Val Leu Arg Val Thr 
        115                 120                 125             


Phe Glu Asp Leu Asp Ser Trp Tyr Phe Gly Asp Arg Gly Gly Glu Tyr 
    130                 135                 140                 


Val Asp Val Ser Asp Leu Glu Val Leu Thr Val Asp Arg Asn Phe Arg 
145                 150                 155                 160 


Val Thr Trp Ala Arg Val Ser Lys Leu Ile Arg His Arg Ala Arg Lys 
                165                 170                 175     


Ile Leu Arg Val His Leu Glu Asp Gly Thr Ile Glu Leu Thr Gly Asn 
            180                 185                 190         


His Ala Val Met Val Leu Asp Glu Gly Gly Leu Arg Ala Val Lys Ala 
        195                 200                 205             


Ser Glu Ile Glu Glu Gly Ser Phe Leu Leu Ser Phe Val Ala Glu Leu 
    210                 215                 220                 


Asp Glu Gln Pro Thr Asp Gly Gly Thr Val Val Thr Ser Val Gly Ser 
225                 230                 235                 240 


Gly Ser Arg Val Ser Asp Thr Thr Tyr Glu Leu Pro Val Glu Val Arg 
                245                 250                 255     


Val Glu Leu Leu Arg Glu Leu Ala Asp Asp Gly Val Ile Glu Ala Ser 
            260                 265                 270         


Glu Asp Val Ser Val Asp Leu Ala Trp Leu Ala Arg Ile Ser Gly Val 
        275                 280                 285             


Glu Ser Arg Val Thr Asp Asp Gly Val Glu Leu Val Trp Glu Thr Arg 
    290                 295                 300                 


Thr Gly Asp Leu Leu Pro Ala Asp Pro Val Leu Lys Leu Val Glu Arg 
305                 310                 315                 320 


Leu Glu Ser Asp Leu Val Asp Asp Leu Glu Ser Trp Val Phe Asp Gly 
                325                 330                 335     


Arg Val Ser Lys Glu Ala Val Arg Lys Val Leu Ser Ser Val Asp Ala 
            340                 345                 350         


Lys Asn Leu Arg Gly Asp Ala Arg Arg Ala Tyr Arg Met Leu Arg Thr 
        355                 360                 365             


Leu Val Arg Ser Asp Val His Ala Val Lys Val Glu Asp Leu Asp Val 
    370                 375                 380                 


Met Asp Tyr Asp Gly Tyr Val Tyr Asp Val Ser Val Pro Gly Asn Glu 
385                 390                 395                 400 


Met Phe Phe Ala Gly Glu Val Pro Val Leu Leu His Asn Ser Gly Val 
                405                 410                 415     


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
            420                 425                 430         


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
        435                 440                 445             


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
    450                 455                 460                 


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
465                 470                 475                 480 


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
                485                 490                 495     


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
            500                 505                 510         


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
        515                 520                 525             


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
    530                 535                 540                 


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
545                 550                 555                 560 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
                565                 570                 575     


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
            580                 585                 590         


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
        595                 600                 605             


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
    610                 615                 620                 


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
625                 630                 635                 640 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
                645                 650                 655     


Ala Thr Arg 
            


<210>  205
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mka_RtcB

<400>  205

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Pro 
            100                 105                 110         


Gly Thr Lys Ile Leu Thr Glu His Gly Cys Trp Val Lys Val Glu Asp 
        115                 120                 125             


Leu Pro Lys Met Leu Thr Asp Gln Lys Leu Lys Val Tyr Asp Val Asp 
    130                 135                 140                 


Glu Gly Arg Glu Asp Asp Ser Glu Ile Lys Phe Val Met Glu Arg Gly 
145                 150                 155                 160 


Ile Glu Glu Asp Glu Arg Ala Val Val Leu Val Thr Glu Ser Gly Leu 
                165                 170                 175     


Thr Ile Glu Gly Ser Glu Asp His Pro Val Leu Thr Pro Glu Gly Tyr 
            180                 185                 190         


Val Glu Leu Gly Glu Ile Glu Glu Gly Asp Leu Val Val Val Tyr Pro 
        195                 200                 205             


Phe Glu Gly Val Glu Tyr Glu Glu Lys Glu Gly Thr Ile Leu Asp Glu 
    210                 215                 220                 


Ser Asp Phe Glu Asp Val Asp Pro Gln Val Leu Arg Tyr Leu Glu Glu 
225                 230                 235                 240 


Arg Asp Leu Ile Pro Leu Arg Trp Ser Asp Pro Lys Val Gly Thr Leu 
                245                 250                 255     


Ala Arg Ile Leu Gly Phe Ala Met Gly Asp Gly His Leu Gly Glu Gln 
            260                 265                 270         


Ala Gly Arg Leu Thr Leu Ser Phe Tyr Gly Asp Glu Arg Thr Leu Arg 
        275                 280                 285             


Glu Leu Lys Arg Asp Leu Glu Ser Leu Gly Val Lys Ala Asn Leu His 
    290                 295                 300                 


Val Arg Lys Arg Arg Tyr Glu Ile Glu Thr Ala Ser Gly Arg Tyr Glu 
305                 310                 315                 320 


Gly Glu Ala Thr Ser Val Glu Leu Arg Val Ala Ser Arg Ser Phe Ala 
                325                 330                 335     


Leu Leu Met Glu Lys Leu Gly Met Pro Arg Gly Arg Lys Val Glu Thr 
            340                 345                 350         


Pro Tyr Lys Val Pro Asp Trp Ile Lys Glu Ala Pro Leu Trp Val Lys 
        355                 360                 365             


Arg Asn Phe Leu Ala Gly Leu Phe Ala Ala Asp Gly Ser Val Val Lys 
    370                 375                 380                 


Phe Lys Arg Tyr Thr Pro Leu Pro Ile Asn Leu Thr Gln Ala Lys Val 
385                 390                 395                 400 


Glu Glu Leu Glu Glu Asn Leu Arg Glu Phe Met Asn Asp Val Ala Lys 
                405                 410                 415     


Leu Leu Arg Glu Phe Gly Ile Glu Thr Thr Leu Tyr Glu Val Lys Ser 
            420                 425                 430         


Lys Lys Asn Val Val Tyr Lys Leu Ala Ile Val Gly Glu Glu Asn Ile 
        435                 440                 445             


Lys Arg Phe Leu Gly Lys Val Gly Tyr Glu Tyr Asp Pro Glu Lys Lys 
    450                 455                 460                 


Val Glu Gly Leu Ala Ala Tyr Ala Tyr Leu Lys Leu Lys Glu Arg Val 
465                 470                 475                 480 


Lys Lys Asp Arg Lys Glu Ala Ala Glu Thr Ala Ala Glu Val Tyr Glu 
                485                 490                 495     


Glu Thr Gly Ser Ile Thr Lys Ala His Glu Ala Val Ala Asp Val Val 
            500                 505                 510         


Asn Arg Arg Phe Val Glu Arg Val Val Tyr Asp Gly Gly Ile Ser Ser 
        515                 520                 525             


Val Arg Val Pro Glu Asp Phe Pro Thr Phe Glu Arg Phe Lys Glu Glu 
    530                 535                 540                 


Arg Val Leu Ala Gly Gly Phe Val Ile Glu Glu Val Val Glu Val Lys 
545                 550                 555                 560 


Gly Val Glu Pro Glu Tyr Asp Arg Phe Tyr Asp Ile Gly Val Cys His 
                565                 570                 575     


Gly Ala His Asn Phe Ile Ala Asp Gly Val Val Val His Asn Ser Gly 
            580                 585                 590         


Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu 
        595                 600                 605             


Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln 
    610                 615                 620                 


Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu 
625                 630                 635                 640 


Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr 
                645                 650                 655     


Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile 
            660                 665                 670         


Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn 
        675                 680                 685             


Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val 
    690                 695                 700                 


Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn 
705                 710                 715                 720 


Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met 
                725                 730                 735     


Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln 
            740                 745                 750         


Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser 
        755                 760                 765             


Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
    770                 775                 780                 


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
785                 790                 795                 800 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
                805                 810                 815     


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
            820                 825                 830         


Ala Ala Thr Arg 
        835     


<210>  206
<211>  871
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mka_VatB

<400>  206

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Pro 
            100                 105                 110         


Gly Thr Arg Val Ile Thr Ala Ser Gly Asp Val Val Glu Ile Asp Glu 
        115                 120                 125             


Ile Val Glu Arg Ala Ala Glu Thr Ala Val Asp Gly Gly Leu Arg Glu 
    130                 135                 140                 


Gly Ser Thr Glu Val Thr Val Gly Val Thr Asn Val Arg Thr Leu Ala 
145                 150                 155                 160 


Ala Trp Asp Gly Asp Leu Thr Ser Asn Asp Val Val Ala Val Glu Lys 
                165                 170                 175     


Ile Glu Ala Pro Ser Arg Ala Val Arg Val Arg Thr Arg Ser Gly Ala 
            180                 185                 190         


Glu Leu Val Val Ser Glu Asp His Lys Phe Leu Val Asp Thr Glu Asp 
        195                 200                 205             


Gly Pro Arg Met Val Glu Ala Ser Glu Leu Lys Ser Gly Asp Glu Leu 
    210                 215                 220                 


Tyr Ser Val Arg Glu Leu Arg Val Ser Glu Lys Val Pro Thr Tyr Leu 
225                 230                 235                 240 


Glu Leu Leu Leu Glu Ala Glu Asp Lys Phe Tyr Val His Pro Thr Glu 
                245                 250                 255     


Glu Phe Glu Glu Ala Val Ala Glu Arg Tyr Gly Ser Leu Ala Glu Ala 
            260                 265                 270         


Cys Arg Glu Lys Glu Leu Pro Tyr Arg Ala Arg Glu Ala Lys Glu Arg 
        275                 280                 285             


Arg Tyr Tyr Glu Leu Ser Glu Phe Ala Arg Leu Ala Thr Ala Val Ile 
    290                 295                 300                 


Glu Ser Val Asp Glu Ala Thr Glu Tyr Ile Asp Tyr Val Thr Ala Gly 
305                 310                 315                 320 


Gly Arg Lys Arg Val Lys Phe Ser Ser Pro Arg Pro Gly Lys Glu Val 
                325                 330                 335     


Met Tyr Val Ala Gly Leu Ile Ala Ser Asp Gly Ser Val Asp Thr Glu 
            340                 345                 350         


Arg Gly Phe Val Met Phe Ser Asn Thr Glu Arg Glu Leu Leu Ser Ala 
        355                 360                 365             


Phe Glu Glu Ile Val Thr Glu Glu Phe Gly Val Asp Ala Ser Lys Thr 
    370                 375                 380                 


Glu Asn Gln Asn Gly Val Thr Met Leu Arg Val Asn Ser Arg Val Leu 
385                 390                 395                 400 


Ala Arg Val Phe Glu Arg Leu Ala Asp Pro Lys Thr Val Leu Lys Met 
                405                 410                 415     


Pro Arg Glu Leu Val Ala Ala Tyr Leu Ala Gly Tyr Val Asp Gly Asp 
            420                 425                 430         


Gly His Leu Lys Asp Gly Lys Ile Val Ile Thr Thr Ala Asp Arg Glu 
        435                 440                 445             


Arg Ala Gly Asp Leu Gln Leu Leu Leu Lys Arg Leu Gly Val Pro Ser 
    450                 455                 460                 


Val Leu Arg Glu Arg Asp Gly Ala Tyr Asp Val Val Val Thr Gly His 
465                 470                 475                 480 


Asp Ala Ala Glu Leu Ala Glu Glu Leu Pro Leu Arg His Pro Lys Lys 
                485                 490                 495     


Ala Glu Ala Ala Ala Ser Met Ser Ser Gly Arg Arg Ser Ser Arg Phe 
            500                 505                 510         


Asp Arg Val Ser Arg Arg Phe Gly Arg Leu Leu Arg Glu Val Arg Arg 
        515                 520                 525             


Lys Tyr Gly Val Arg Ala Ser Asp Leu Gly Ser Ser Ser Thr Ile Ser 
    530                 535                 540                 


Gln Ile Glu Ser Gly Glu Arg Arg Ala Thr Arg Arg Leu Ala Leu Glu 
545                 550                 555                 560 


Ile Val Glu Arg Leu Glu Glu Val Val Gly Asp Val Glu Glu Val Arg 
                565                 570                 575     


Glu Leu Arg Glu Leu Ala Glu Gly Asn Tyr Val Leu Asp Glu Val Val 
            580                 585                 590         


Glu Val Glu Thr Val Glu Tyr Glu His Glu Tyr Leu Tyr Asp Val Thr 
        595                 600                 605             


Val Val Pro Asp His Thr Leu Val Val Glu Asn Gly Ile Ile Thr Ser 
    610                 615                 620                 


Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
625                 630                 635                 640 


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
                645                 650                 655     


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
            660                 665                 670         


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
        675                 680                 685             


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
    690                 695                 700                 


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
705                 710                 715                 720 


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
                725                 730                 735     


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
            740                 745                 750         


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
        755                 760                 765             


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
    770                 775                 780                 


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
785                 790                 795                 800 


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
                805                 810                 815     


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
            820                 825                 830         


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
        835                 840                 845             


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
    850                 855                 860                 


Asn Ala Glu Ala Ala Thr Arg 
865                 870     


<210>  207
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:MP-Be_gp51

<400>  207

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Ser Trp Thr 
            100                 105                 110         


Asn Ala Arg Ala Val Thr Arg Arg Gly Phe Val His Val Asp Asp Leu 
        115                 120                 125             


Thr Thr Asp Asp Glu Val Met Ser Val Asp Asp Gln Gly Arg Thr Ile 
    130                 135                 140                 


Trp Gln Gln Ile Asp Glu Val Val Arg Phe Pro Phe Ser Gly Thr Leu 
145                 150                 155                 160 


Tyr Ser Leu Gly Gly Arg Glu Ile Asn Ala Thr Ile Thr Ala Asn His 
                165                 170                 175     


Arg Val Val Gly Leu Asn Arg Glu Lys Thr Lys Trp Val Glu His Thr 
            180                 185                 190         


Pro Thr Ser Leu Pro Gly Asn Lys Met Trp Val Tyr Thr Ala Gly Glu 
        195                 200                 205             


Gly Ser Asn Glu Asp Tyr Pro Leu Thr Asp Thr Glu Ile Arg Leu Ala 
    210                 215                 220                 


Val Trp Gly Leu Thr Asp Ser His Arg Ser Pro Asp Gly Arg Trp Thr 
225                 230                 235                 240 


Phe Tyr Gln Ser Gly Glu Lys Ala Glu Gln Val Arg Lys Leu Leu Ala 
                245                 250                 255     


Asp Ala Gly Ile Glu Tyr Arg Glu Arg Ala Arg Asn Arg Gly Ile Thr 
            260                 265                 270         


Glu Ile Asp Gly Lys Val Leu Lys Ala Pro Pro Lys Thr Gln Tyr Glu 
        275                 280                 285             


Phe Ser Leu Gly Lys Val Gln Glu Leu Asp Asp Leu Leu Asp Arg Gly 
    290                 295                 300                 


Arg Ser Glu Leu Pro Thr Trp Thr Leu Ser Leu Ser Gln Arg Gln Ala 
305                 310                 315                 320 


Arg Leu Phe Leu Glu Glu Tyr Arg Phe Thr Asp Gly Thr Asp Thr Thr 
                325                 330                 335     


Ser Ala Gly Asp Ser Tyr Val Leu Tyr Val Cys Lys Asp Arg Met Arg 
            340                 345                 350         


Glu Gln Leu Gln Met Leu Ala Ala Ala Asn Gly Leu Arg Ala Ser Thr 
        355                 360                 365             


Thr Glu Tyr Arg Pro Gly His Trp Arg Leu Asn Ile Ser Asn Arg Ala 
    370                 375                 380                 


Leu Ser Gly Leu Tyr Lys Asn Thr Val Glu Glu Val Ala Tyr Glu Gly 
385                 390                 395                 400 


Glu Val Trp Cys Leu Arg Val Pro Asn Gly Arg Phe Phe Ile Glu Asp 
                405                 410                 415     


Gly Gly Lys Ile His Leu Thr Gly Asn Ser Gly Val Lys Val Ala Val 
            420                 425                 430         


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
        435                 440                 445             


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
    450                 455                 460                 


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
465                 470                 475                 480 


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
                485                 490                 495     


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            500                 505                 510         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        515                 520                 525             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    530                 535                 540                 


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
545                 550                 555                 560 


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
                565                 570                 575     


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
            580                 585                 590         


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
        595                 600                 605             


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
    610                 615                 620                 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
625                 630                 635                 640 


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
                645                 650                 655     


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            660                 665                 670     


<210>  208
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:MP-Catera_gp206

<400>  208

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Leu Ala Cys 
            100                 105                 110         


Ser Thr Pro Ile Leu Thr Thr Asn Gly Trp Ser Thr Met Gly Ala Leu 
        115                 120                 125             


Gln Asp Gly Asp Glu Val Tyr Ala Pro Asp Gly Gln Pro Thr Lys Val 
    130                 135                 140                 


Ile Lys Ala His Pro Ile Asn Leu Asn Arg Pro Cys Phe Lys Val Arg 
145                 150                 155                 160 


Phe Arg Asp Gly Gln Glu Val Val Thr Asp Ala Glu His Leu Trp Gln 
                165                 170                 175     


Val Asn Asp Arg Asn Asn Gly Gly Arg Asp Arg Val Met Thr Thr Gln 
            180                 185                 190         


Glu Ile Ala Asp Ala Pro Trp Gly Gly Arg Tyr Arg Phe Arg Val Pro 
        195                 200                 205             


Val Thr Glu Pro Leu Gln Thr Pro Glu Ala Asp Leu Pro Val Asp Pro 
    210                 215                 220                 


Trp Leu Leu Gly Ala Trp Leu Gly Asp Gly Asp Ala Ser Met Val Ser 
225                 230                 235                 240 


Ile Cys Ser Gly Ser Gln Asp Leu Asp Tyr Leu Ile Ser Arg Val Glu 
                245                 250                 255     


Gly Leu Gly Leu Ser His Arg Val Asn Arg Tyr Gly Ser Arg Ala Ala 
            260                 265                 270         


Ser Val Tyr Val His Gly Met Arg Ala Val Phe Ser Glu Leu Gly Leu 
        275                 280                 285             


Leu Lys Asn Lys His Ile Pro Asp Arg Tyr Leu Thr Ala Ser Val Ala 
    290                 295                 300                 


Gln Arg Arg Gln Leu Leu Ala Gly Leu Met Asp Ser Asp Gly Thr Val 
305                 310                 315                 320 


Ser Asp Arg Gln Val Thr Ile Ser Met Lys Asn Glu Arg Leu Met Arg 
                325                 330                 335     


Gln Val Leu Gln Leu Val Arg Ser Leu Gly Tyr Arg Ala Gly Phe Gly 
            340                 345                 350         


Ser Arg Met Ala Arg Leu Asn Gly Arg Asp Cys Gly Leu Val Tyr Val 
        355                 360                 365             


Val Arg Phe His Thr Gly Trp Gly Glu Ser Pro Phe Asp Met Pro Arg 
    370                 375                 380                 


Lys Arg Asp Gly Trp Glu Gln Ala Thr Lys Thr Ser Val Gln Asn Leu 
385                 390                 395                 400 


Arg Leu Asn Ala Ile Val Ala Val Glu Pro Val Glu Thr Val Pro Val 
                405                 410                 415     


Arg Cys Ile Thr Val Ala His Glu Ser Ser Leu Tyr Val Ala Gly Glu 
            420                 425                 430         


Gly Phe Val Pro Thr His Ser Gly Val Lys Val Ala Val Leu Asp Thr 
        435                 440                 445             


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
    450                 455                 460                 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
465                 470                 475                 480 


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
                485                 490                 495     


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
            500                 505                 510         


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
        515                 520                 525             


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
    530                 535                 540                 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
545                 550                 555                 560 


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
                565                 570                 575     


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
            580                 585                 590         


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
        595                 600                 605             


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
    610                 615                 620                 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
625                 630                 635                 640 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
                645                 650                 655     


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
            660                 665                 670         


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680                 


<210>  209
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mxa_RAD25

<400>  209

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Lys Asn 
            100                 105                 110         


Asp Ser Leu Ile Phe Thr Asp Arg Gly Leu Val Thr Ala Ala Glu Leu 
        115                 120                 125             


Ala Val Gly Val Pro Glu Glu His Ala Ala Phe Thr Glu Val Gly Val 
    130                 135                 140                 


Asp Thr Ser Thr Gly Arg Ala Thr Thr Asn Ala Val Tyr Asn Gly Gly 
145                 150                 155                 160 


Arg Ser Pro Thr Lys Arg Ala Arg Leu Ala Leu Gly Tyr Glu Leu Glu 
                165                 170                 175     


Ala Thr Pro Glu His Pro Ile Arg Val Leu Arg Asp Asp Ala Leu Ala 
            180                 185                 190         


Trp Val Arg Met Asp Glu Leu His Val Gly Asp Arg Val Ala Leu Arg 
        195                 200                 205             


Arg Gly Ser Glu Val Trp Gly Arg Ser Ser Leu Pro Glu Ala Phe Arg 
    210                 215                 220                 


Trp Val Lys Pro Lys Tyr Ala Ala Asn Leu Lys Leu Pro Lys Gly Leu 
225                 230                 235                 240 


Val Leu Asp Glu Val Ala Ala Glu Ala Cys Gly Leu Leu Val Ser Glu 
                245                 250                 255     


Gly Thr Leu Thr Lys Arg Leu Val Thr Glu Phe Thr Asn Ala Asp Ala 
            260                 265                 270         


Asp Asn Val Gly Phe Ile Ser Arg Trp Ala Ala Ser Ile Gly Ile Asp 
        275                 280                 285             


Leu Ser Arg Asn Gly Ser Asp Ser Ile Gln Tyr Leu Leu Cys Ser Val 
    290                 295                 300                 


Val Leu Arg Glu Trp Leu Ala Trp Leu Gly Leu Asp Tyr Thr Arg Ala 
305                 310                 315                 320 


Ala Gly Lys Cys Ile Pro Arg Ala Val Arg Phe Gly Gly Arg Asp Ile 
                325                 330                 335     


Met Arg Ala Phe Leu Arg Gly Leu Phe Asp Gly Asp Ala Ser Val Asp 
            340                 345                 350         


Pro Leu Lys Gly Val Ile Glu Phe Cys Thr Ala Ser Glu Arg Met Ala 
        355                 360                 365             


Arg Glu Val Gln Val Ala Leu Leu Gly Leu Gly Ile Leu Ala Ser Arg 
    370                 375                 380                 


His Ser Arg Thr Val Ala Gly Tyr Glu Gln Leu Tyr Trp Arg Val Thr 
385                 390                 395                 400 


Val Asn Asp Val Ala Thr Phe Glu Arg Glu Val Gly Phe Ser Ser Asn 
                405                 410                 415     


Trp Asn Arg Leu Arg Leu Arg Glu Ala Val Ala Arg Ala Glu Gly Arg 
            420                 425                 430         


Cys Arg Asn Pro Asn Val Asp Thr Val Pro Ile Asn Gly Leu Val Glu 
        435                 440                 445             


Arg Leu Tyr Arg Thr Ala Gln Lys Gln Leu Ser Trp Ser Ser Gln Glu 
    450                 455                 460                 


Gly Arg Ile Phe Gly Asn Tyr Val His Gly Glu His Ala Pro Ser Arg 
465                 470                 475                 480 


Ala Ala Leu Glu Arg Met Val Gln Arg Trp Gly Ser Glu Cys Pro Thr 
                485                 490                 495     


Glu Cys Leu Pro Ile Glu Ala Phe Leu Glu Leu Pro Val Ala Phe Leu 
            500                 505                 510         


Ser Val Glu Ser Ile Glu Asp Gly Glu Ala Asp Val Val Asp Leu Ser 
        515                 520                 525             


Val Pro Glu Thr His Glu Phe Val Ala Asn Gly Val Val Cys His Asn 
    530                 535                 540                 


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
545                 550                 555                 560 


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
                565                 570                 575     


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
            580                 585                 590         


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
        595                 600                 605             


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
    610                 615                 620                 


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
625                 630                 635                 640 


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
                645                 650                 655     


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
            660                 665                 670         


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
        675                 680                 685             


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
    690                 695                 700                 


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
705                 710                 715                 720 


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
                725                 730                 735     


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
            740                 745                 750         


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
        755                 760                 765             


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
    770                 775                 780                 


Ala Glu Ala Ala Thr Arg 
785                 790 


<210>  210
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Nfa_DnaB

<400>  210

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Pro Ala 
            100                 105                 110         


Ser Thr Arg Ile Leu Arg Ala Asp Thr Gly Ala Glu Ser Thr Leu Gly 
        115                 120                 125             


Glu Leu Leu Ala Ser Gly Glu Gln Pro Leu Val Trp Ser Leu Asp Glu 
    130                 135                 140                 


Arg Met Arg Met Val Ala Arg Pro Met Val Lys Val Phe Pro Ser Gly 
145                 150                 155                 160 


Arg Lys Glu Val Phe Arg Leu Arg Leu Ala Ser Gly Arg Glu Val Glu 
                165                 170                 175     


Ala Thr Gly Asn His Pro Phe Leu Thr Val Asp Gly Trp Ile Pro Leu 
            180                 185                 190         


Asp Arg Leu Thr Val Gly Asp Arg Leu Ala Thr Pro Arg Ser Val Pro 
        195                 200                 205             


Glu Pro Val His Thr Glu Arg Met Ala Asp Ala Glu Val Val Leu Leu 
    210                 215                 220                 


Ala His Met Ile Gly Asp Gly Ser Cys Val Arg Arg Gln Pro Val Arg 
225                 230                 235                 240 


Tyr Ala Ser Ile Asp Glu Gln Asn Leu Ala Ala Val Ser Glu Ala Ala 
                245                 250                 255     


Glu His Phe Gly Val Thr Ala Val Arg Asp Asp Tyr Ala Ala Ala Arg 
            260                 265                 270         


Val Thr Thr Leu Arg Leu Pro Ala Pro Tyr Arg Leu Ser Arg Gly Lys 
        275                 280                 285             


Arg Asn Pro Ile Ala Ala Trp Leu Asp Glu Leu Gly Leu Phe Gly Leu 
    290                 295                 300                 


Arg Ser His Glu Lys Phe Ile Pro Arg Arg Val Phe Ala Leu Pro Asn 
305                 310                 315                 320 


Asp Gln Val Ala Leu Phe Leu Arg His Leu Trp Ala Thr Asp Gly Ser 
                325                 330                 335     


Val Arg Trp Asp Ser Thr Tyr Arg Gln Ala Arg Val Tyr Tyr Thr Ser 
            340                 345                 350         


Thr Ser Arg Arg Leu Ile Asp Asp Val Ala Gln Leu Leu Leu Arg Leu 
        355                 360                 365             


Gly Val His Gly Arg Ile Arg Arg Val Thr Lys Pro Gly Tyr Arg Asp 
    370                 375                 380                 


Ala Trp His Leu Thr Ile Asp Gly Ala Asp Asn Gln Thr Val Phe Leu 
385                 390                 395                 400 


Arg Asp Val Gly Val His Gly Ala Arg Gly Asp Ala Ala Gln Val Ala 
                405                 410                 415     


Leu Ala Glu Leu Glu Pro Leu Val Arg Asn Thr Asn Val Asp Thr Val 
            420                 425                 430         


Pro Asn Glu Val Trp Asn Gln Val Arg His Leu Leu Ala Thr Lys Asn 
        435                 440                 445             


Ile Thr His Arg Glu Phe Ser Ala Ala Met Gly Ser Arg Phe Cys Gly 
    450                 455                 460                 


Ser Thr Met Trp Lys Arg Ser Pro Ser Arg Ser Arg Leu Ala Arg Val 
465                 470                 475                 480 


Ala Ala Val Leu Asp Asp Ala Asp Ile Glu Met Tyr Ala Thr Asn Asp 
                485                 490                 495     


Val Phe Trp Asp Lys Ile Val Glu Ile Thr Ser Leu Gly Glu Gln Asp 
            500                 505                 510         


Val Tyr Asp Gly Thr Val Pro Gly Thr His Asn Phe Val Ala Gln Ser 
        515                 520                 525             


Ile Ser Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
    530                 535                 540                 


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
545                 550                 555                 560 


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
                565                 570                 575     


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
            580                 585                 590         


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
        595                 600                 605             


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
    610                 615                 620                 


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
625                 630                 635                 640 


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
                645                 650                 655     


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
            660                 665                 670         


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
        675                 680                 685             


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
    690                 695                 700                 


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
705                 710                 715                 720 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
                725                 730                 735     


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
            740                 745                 750         


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
        755                 760                 765             


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 


<210>  211
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Nfa_Nfa15250

<400>  211

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Pro Ala 
            100                 105                 110         


Gly Thr Val Val Ser Gly Pro Ser Ala Glu Ala Ala Thr Arg Arg Trp 
        115                 120                 125             


Phe Glu Gly Glu Leu Val Val Phe Thr Thr Ala Ser Gly Lys Gln Leu 
    130                 135                 140                 


Ser Leu Thr Gly Asn His Pro Val Leu Thr Arg Gly Gly Trp Val Pro 
145                 150                 155                 160 


Ala Asn Leu Leu Asn Glu Gly Asp Glu Val Val Arg Ser Thr Arg Pro 
                165                 170                 175     


Gln Gly Ala Thr Pro Leu Val Val Pro Asp His His Gln Val Pro Ala 
            180                 185                 190         


Leu Ile Glu Asp Val Trp Gly Ser Phe Ala Val Asn Gly Leu His Arg 
        195                 200                 205             


Val Pro Ala Ala Pro Glu Asp Phe His Gly Asp Gly Gln Arg Gly Glu 
    210                 215                 220                 


Val Asp Ile Val Gly Pro Asp Arg Thr Leu Trp Cys Gly His Asp Ala 
225                 230                 235                 240 


Ala Ile Ala Gln Gln Arg Glu Gln Gln Phe Phe Thr Arg Arg Thr Glu 
                245                 250                 255     


Ser Ser Gly Leu Leu Val Ala Glu Ser Val Ala Gln Leu Val Asp Leu 
            260                 265                 270         


Trp Gln Ala Pro His Ser Gly Ser Ser Ile Gly Arg Ser Gly Leu Pro 
        275                 280                 285             


Phe Ala Leu Ile Gly Gly His Gly Gly Gly Pro Val Glu Arg Gly Leu 
    290                 295                 300                 


Thr Val Ala Ala Gly Gly Tyr Pro Gly Leu His Glu Ala Leu Ala Asp 
305                 310                 315                 320 


Tyr Arg Pro Gly Asp Ala Val Leu Pro Pro Gln Gly Val Phe Ala Gly 
                325                 330                 335     


Ser Ser Glu Ile Gly Gly Asp Asp Cys Val Ile Gly Lys Val Asp Ser 
            340                 345                 350         


Thr Arg Trp Asp Ala Pro Ala Leu Pro Phe Leu Val Glu Gly Arg Ala 
        355                 360                 365             


Gly Tyr Ala Ser Arg Gly Lys Glu Leu Phe Asp Arg Leu Thr Gly Gln 
    370                 375                 380                 


Val Glu Leu Asp Arg Ile Val Ile Leu Arg Arg Val Gln Trp Ser Gly 
385                 390                 395                 400 


His Val Phe Ser Leu Thr Ser Ser Glu Gly Trp His Thr Gly Asn Ser 
                405                 410                 415     


Leu Ile Val Ser Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
            420                 425                 430         


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
        435                 440                 445             


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
    450                 455                 460                 


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
465                 470                 475                 480 


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
                485                 490                 495     


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
            500                 505                 510         


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
        515                 520                 525             


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
    530                 535                 540                 


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
545                 550                 555                 560 


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
                565                 570                 575     


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
            580                 585                 590         


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
        595                 600                 605             


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
    610                 615                 620                 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
625                 630                 635                 640 


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
                645                 650                 655     


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            660                 665         


<210>  212
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Nfa_RIR1

<400>  212

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Pro Ala 
            100                 105                 110         


Gly Thr Pro Val Asp Thr Ile Asp Gly Pro Lys Pro Ile Glu Ser Leu 
        115                 120                 125             


Arg Ala Gly Asp Arg Val Leu Ser His Asp Gly Ser Tyr Ala Thr Val 
    130                 135                 140                 


Glu Lys Leu Ile Glu Asn Thr Asn Asp Gln Pro Leu Val Ser Ile Ser 
145                 150                 155                 160 


His Phe Gly His Lys Glu Pro Ile Arg Cys Thr Pro Glu His Pro Ile 
                165                 170                 175     


Leu Val Trp Thr Asp Arg Asp Val Glu Thr Leu Ile Asp Gly Asp Gly 
            180                 185                 190         


Ala Asp Pro Phe Asn Gly Phe Val Trp Leu Ala Ala Gln Asp Val His 
        195                 200                 205             


Pro Ser Asp Phe Ile Val Ala Thr Ala Pro Leu Glu Thr Arg Glu Arg 
    210                 215                 220                 


Arg Val Phe Asp Leu Met Asn His Val Gly Glu Gly Thr Tyr Glu Glu 
225                 230                 235                 240 


Val Asp Gly Leu Ile Arg Lys Val Asn Thr Asp Ala Arg His Arg Asn 
                245                 250                 255     


Lys Gln Arg His Arg Gln Gly Phe Val Ala Val Thr Arg Tyr Val Glu 
            260                 265                 270         


Glu Ser Tyr Asp Leu Gly Leu Ile Leu Gly Trp Tyr Leu Ala Glu Gly 
        275                 280                 285             


His Val Ser Lys Arg Ser Gly Val Glu Asp Val Arg Pro Thr Gly Val 
    290                 295                 300                 


His Phe Thr Leu Gly Ala Asn Glu Ile Glu Arg His Val Glu Leu Gly 
305                 310                 315                 320 


Met Ala Phe Lys Gln Val Phe Gly Val Asp Leu Val Leu His Thr Asn 
                325                 330                 335     


His Ser Asp His Ser Thr Arg Met Val Cys Asn Ser Lys Ile Val Ala 
            340                 345                 350         


Ser Leu Leu Leu Ser Leu Ala Gly Thr Gly Tyr Ser Thr Lys Arg Leu 
        355                 360                 365             


Ala His Glu Val Met Thr Ala Asp Glu Asp Phe Gln Arg Gly Leu Leu 
    370                 375                 380                 


Val Gly Leu Phe Arg Gly Asp Gly Cys Thr Thr Thr Gly Gly Met Val 
385                 390                 395                 400 


Leu Asp Leu Val Asn Gln Glu Leu Ile Asp Gln Val Gln Leu Leu Leu 
                405                 410                 415     


Arg Arg Leu Gly Ile Val Ser Val Val Arg Thr Tyr Thr Asn Gln Ala 
            420                 425                 430         


Gly Asn Pro Thr Gly Gln Val Phe Val Pro Gly Leu Pro Gly Thr Asn 
        435                 440                 445             


Glu Glu Phe Ile Phe Asp Val Asp Lys Asn Leu Gln Asn Tyr Thr Gly 
    450                 455                 460                 


Arg Lys Gly Thr Lys Arg Thr Thr Tyr Gln Val Val His Gly Arg His 
465                 470                 475                 480 


Val Tyr Gly Ile Arg Ala Val Glu Arg Thr Gly Glu Thr Pro Arg Gln 
                485                 490                 495     


Val Tyr Asn Leu His Val Glu Gly Thr His Thr Tyr Thr Ile Arg Gly 
            500                 505                 510         


Ala Val Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
        515                 520                 525             


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
    530                 535                 540                 


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
545                 550                 555                 560 


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
                565                 570                 575     


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
            580                 585                 590         


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
        595                 600                 605             


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
    610                 615                 620                 


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
625                 630                 635                 640 


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
                645                 650                 655     


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
            660                 665                 670         


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
        675                 680                 685             


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
    690                 695                 700                 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
705                 710                 715                 720 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
                725                 730                 735     


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
            740                 745                 750         


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760             


<210>  213
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Nph_CDC21

<400>  213

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Asp Gly 
            100                 105                 110         


Asp Thr Ser Val Thr Leu Ala Ser Gly Asp Glu Lys Pro Ile Arg Asp 
        115                 120                 125             


Ile Val Glu Ser Thr Leu Glu Asp Pro Thr Glu Ile Ser Asp Gly Phe 
    130                 135                 140                 


Tyr Gln Glu Ser Asp Ile Asp Val Leu Thr Thr Asp Gly Gly Ala Val 
145                 150                 155                 160 


Ala Pro Gly Arg Ala Thr Lys Val Trp Lys Arg Gln Ala Pro Glu Lys 
                165                 170                 175     


Met Tyr Arg Ile Arg Thr Glu Ser Gly Arg Glu Leu Glu Val Thr Pro 
            180                 185                 190         


Ser His Pro Leu Phe Val Gln Ser Glu Gly Gly Leu Ser Pro Leu Val 
        195                 200                 205             


Ala Asp Asp Leu Ser Glu Asn Asp Phe Val Ala Val Pro Arg Ala Leu 
    210                 215                 220                 


Pro Ala Asp Asp Gly Asp Asp Phe Gly Gln His Val Asp Asp Leu Gly 
225                 230                 235                 240 


Ser Val Thr Ala Arg Lys Thr Ala Asp Ala Glu Ala Val Arg Ser Glu 
                245                 250                 255     


Asp Ala Ala Thr Thr Pro Asp Val Ile Pro Asn Val Gly Asp Gln Leu 
            260                 265                 270         


Arg Arg Ile Arg Thr Ser Leu Arg Leu Ser Gln His Asp Cys Gly Leu 
        275                 280                 285             


Pro Arg Ser Thr Tyr Gln Gln Tyr Glu Arg Gly Asp Arg Asn Pro Ser 
    290                 295                 300                 


Arg Ser Arg Leu Gln Thr Val Leu Thr Ala Phe Glu Arg Arg Ile Glu 
305                 310                 315                 320 


Gln Leu Ser Ser Leu Ser Asp Arg Val Asp Asp Gly Asp Ser Asp Ala 
                325                 330                 335     


Ile Ala Ala Ala Arg Asp Glu Leu Asn Pro Ser Gln Ala Ser Leu Ala 
            340                 345                 350         


Ser Gly Met Asp Ala Thr Arg Thr Ala Ile Gly Asp Asp Glu Arg Thr 
        355                 360                 365             


Glu Ala Arg Pro Asp Gly Gly Ala Val Ala Asp Ala Glu Arg Ala Val 
    370                 375                 380                 


Ala Asp Ala Leu Cys Arg Ala Leu Ala Val Ala Asp Asp Val Glu Arg 
385                 390                 395                 400 


Leu Arg Ser Leu Ala Asp Gly Asp Ile Gly Trp Asp Arg Ile Asp Ser 
                405                 410                 415     


Ile Glu Pro Val Glu Pro Glu Asp Glu Trp Val Tyr Asp Leu Glu Val 
            420                 425                 430         


Glu Ser Thr His Ser Tyr Leu Ser Asn Asp Val Val Ser His Asn Ser 
        435                 440                 445             


Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp 
    450                 455                 460                 


Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr 
465                 470                 475                 480 


Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala 
                485                 490                 495     


Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu 
            500                 505                 510         


Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser 
        515                 520                 525             


Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala 
    530                 535                 540                 


Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala 
545                 550                 555                 560 


Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly 
                565                 570                 575     


Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
            580                 585                 590         


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
        595                 600                 605             


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
    610                 615                 620                 


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
625                 630                 635                 640 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                645                 650                 655     


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            660                 665                 670         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        675                 680                 685             


Glu Ala Ala Thr Arg 
    690             


<210>  214
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Nph_rPol_App

<400>  214

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Ile Pro Ala 
            100                 105                 110         


Asp Glu Gln Val Val Val Arg Arg Asn Gly Glu Thr Glu Leu Thr Glu 
        115                 120                 125             


Ile Gly Pro Leu Val Asp Ser Leu Met Asp Ser Arg Glu Thr Arg Ser 
    130                 135                 140                 


Phe Asp Asp His Glu Val Thr Leu Ala Pro Asp Gly Ile Glu Val Pro 
145                 150                 155                 160 


Ser Leu Ser Ser Glu Glu Thr Val Glu Trp Lys Pro Ile Glu Glu Val 
                165                 170                 175     


Ser Arg His Glu Thr Pro Asp Glu Leu Leu Arg Phe Glu Leu Glu Ser 
            180                 185                 190         


Gly Arg Ser Ile Arg Ala Thr Lys Ala His Ser Phe Val Thr Arg Gln 
        195                 200                 205             


Glu Asn Glu Val Val Pro Val Ala Gly Glu Glu Leu Glu Ala Gly Asp 
    210                 215                 220                 


Trp Leu Pro Val Val Ala Ser Leu Asp Ala Thr Asp Thr Gln Glu Thr 
225                 230                 235                 240 


Val Asp Leu Arg Lys Tyr Leu Pro Ala Gly Asp Tyr Trp Tyr Thr Ser 
                245                 250                 255     


Val Leu Ala Asp Gly Gly Ala Glu Ala Val Pro Gly Gly Pro Asp Gln 
            260                 265                 270         


Leu Arg Asn Lys Arg Ala Ala Leu Glu Ala Gly Glu Leu Ala Glu His 
        275                 280                 285             


Thr Ala Tyr Pro Val Gln Gly Thr Val Gly Leu Pro Glu Gln Phe Pro 
    290                 295                 300                 


Leu Asp Glu Glu Thr Gly Phe Phe Val Gly Ala Trp Leu Ala Glu Gly 
305                 310                 315                 320 


Ser Leu Ala Asp His Tyr Val Ser Ile Ser Asn Val Asp Ala Ala Phe 
                325                 330                 335     


Gln Ser Arg Ile Arg Ser Phe Ala Glu Arg Phe Asp Leu Thr Val Asn 
            340                 345                 350         


Glu Tyr Glu Asn Asp Ser Gly Phe Ala Ala Gly Tyr Asp Ile Arg Leu 
        355                 360                 365             


Asn Gly Thr Ile Leu Ser Asp Phe Leu Arg Ala Ala Cys Thr Asp Asp 
    370                 375                 380                 


Gly Glu Lys Ser Ile Pro Gly Phe Ala Ile Gly Ala Asn Glu Ala Phe 
385                 390                 395                 400 


Leu Lys Gly Leu Leu Gln Gly Tyr Phe Ser Gly Asp Gly Asn Val Gly 
                405                 410                 415     


Thr Asn Ala Ile Arg Ser Ser Ser Thr Ser Asp Arg Leu Thr Ala Gly 
            420                 425                 430         


Val Gly Leu Leu Leu Ala Arg Phe Asp Val Tyr Ala Thr Leu Gly Gln 
        435                 440                 445             


Gln Glu Asp Ser Arg Thr Leu Arg Val Pro Lys Lys His Val Ser Arg 
    450                 455                 460                 


Phe Asp Asn Arg Ile Gly Met Val Gly Glu Arg Gly Ala Glu Leu Glu 
465                 470                 475                 480 


Ala Leu Ala Glu Ser Ala Asp Ser Asp Gly Pro Asp Ala Thr Asp Gln 
                485                 490                 495     


Ile Pro Asn Phe Gly Asp Ala Leu Glu Ala Val Ala Glu Ala Ala Asp 
            500                 505                 510         


Ile Pro Gln Arg Gln Val Asn Ser Ala Thr Lys Arg Gln Arg Ile Asp 
        515                 520                 525             


Arg Ser Arg Leu Ala Arg Leu Val Ala Ala Ala Glu Ala Glu Leu Asp 
    530                 535                 540                 


Gly Glu Gln Ser Glu Leu Asp Ala Leu Arg Gln Ala Val Thr Gly Asp 
545                 550                 555                 560 


Val Val Trp Asp Arg Ile Glu Ser Ile Glu Thr Val Glu Ser Asp His 
                565                 570                 575     


Glu Tyr Val Tyr Asp Val Ser Val Glu Gly Leu Glu Thr Phe Thr Thr 
            580                 585                 590         


Ala Asp Gly Val Val Thr His Asn Ser Gly Val Lys Val Ala Val Leu 
        595                 600                 605             


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
    610                 615                 620                 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
625                 630                 635                 640 


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
                645                 650                 655     


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
            660                 665                 670         


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
        675                 680                 685             


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
    690                 695                 700                 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
705                 710                 715                 720 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
                725                 730                 735     


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
            740                 745                 750         


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
        755                 760                 765             


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
    770                 775                 780                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
785                 790                 795                 800 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                805                 810                 815     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            820                 825                 830         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840                 845     


<210>  215
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Npu_GyrB

<400>  215

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ile Gly 
            100                 105                 110         


Asp Thr Leu Ile Pro Leu Ala Asp Gly Lys Ser Tyr Arg Ile Lys Asp 
        115                 120                 125             


Leu Met Asp Trp Gly Thr Glu Phe Ile Val Tyr Ala Cys Thr Pro Thr 
    130                 135                 140                 


Gly Lys Ile Val Ala Ala Gln Ala Thr Ala Lys Leu Thr Arg Arg Asn 
145                 150                 155                 160 


Ala Pro Leu Val Lys Val Ile Leu Asp Asn Gly Glu Glu Ile Ile Cys 
                165                 170                 175     


Thr Pro Asp His Gln Phe Met Leu Arg Asp Gly Thr Tyr Lys Glu Ala 
            180                 185                 190         


Gln Leu Leu Gln Ala Glu Thr Ser Leu Met Pro Phe Tyr Ser Lys Thr 
        195                 200                 205             


Asp Lys Asp Gly Tyr Thr Leu Ile Thr Gln Pro Tyr Ser Ser Arg Trp 
    210                 215                 220                 


Gln Lys Ala His Trp Ile Ile Ala Arg Ser Gly Leu Leu Gly Lys Val 
225                 230                 235                 240 


Pro Arg Phe Glu Gly Gln Lys Thr Phe Ile His His Gln Asn Phe Asp 
                245                 250                 255     


Glu Ser Asp Asn Arg Pro Glu Asn Leu Glu Phe Met Gly Asn Arg Asp 
            260                 265                 270         


His Ser Ala Tyr His Arg Ser Leu Val Glu Arg Asn Gln His Trp His 
        275                 280                 285             


Ser Ala Glu Phe Glu Glu Lys Arg Val Ala Ser Leu Ala Gln Lys Ala 
    290                 295                 300                 


Lys Thr Ser Glu Gly Tyr Gln Tyr Tyr Ala Glu Arg Gly Thr Arg Asn 
305                 310                 315                 320 


Ile Phe Gln Tyr Met Glu Gln Gln Pro Glu His Phe Lys Asn Ala Val 
                325                 330                 335     


Ala Gly Asn Gly Asn Arg Gly Lys Gln Tyr Leu Val Glu Tyr Asn Lys 
            340                 345                 350         


Thr Glu Lys Gly Arg Gly Lys Ser Gln Glu Ile Ala Asn Arg Tyr Tyr 
        355                 360                 365             


Thr Cys Glu Ile Cys Gly Val Asp Val Lys Thr Pro Ile Gly Leu His 
    370                 375                 380                 


Asn His Arg Arg Lys Glu His Gln Cys Asn His Lys Val Val Ala Val 
385                 390                 395                 400 


Asn Leu Leu Asn Tyr Thr Glu Asp Val Tyr Cys Leu Thr Val Pro Glu 
                405                 410                 415     


Tyr His Asn Phe Ala Leu Lys Ala Gly Val Phe Val His Asn Ser Gly 
            420                 425                 430         


Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu 
        435                 440                 445             


Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln 
    450                 455                 460                 


Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu 
465                 470                 475                 480 


Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr 
                485                 490                 495     


Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile 
            500                 505                 510         


Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn 
        515                 520                 525             


Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val 
    530                 535                 540                 


Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn 
545                 550                 555                 560 


Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met 
                565                 570                 575     


Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln 
            580                 585                 590         


Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser 
        595                 600                 605             


Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
    610                 615                 620                 


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
625                 630                 635                 640 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
                645                 650                 655     


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
            660                 665                 670         


Ala Ala Thr Arg 
        675     


<210>  216
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Nsp-JS614_DnaB

<400>  216

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ala Leu Ala Leu 
            100                 105                 110         


Asp Thr Ala Leu Pro Thr Pro Ser Gly Trp Thr Thr Met Gly Asp Val 
        115                 120                 125             


Gln Val Gly Asp Gln Leu Tyr Asp Ala His Gly Arg Pro Thr Thr Val 
    130                 135                 140                 


Val Ala Ala Thr Glu Val Leu Thr Gly Arg Pro Cys Tyr Glu Val Glu 
145                 150                 155                 160 


Phe Ser Asp Gly Ser Arg Ile Val Ala Asp Ala Gln His Gln Trp Leu 
                165                 170                 175     


Thr Glu Ser Arg Ala Ala Arg Lys Ser Arg Trp Ala Ala Asp Lys Gln 
            180                 185                 190         


Tyr Asn Arg Ala Arg Asn Gln Asn Ile Val Ala Ser Val Val Thr Thr 
        195                 200                 205             


Glu Ala Ile Ala Gly Thr Leu Arg Val Gly Ala Asp Gln Arg Ala Asn 
    210                 215                 220                 


His Ala Val Leu Thr Ala Asp Pro Leu Ser Gly Ser Asp Val Asp Leu 
225                 230                 235                 240 


Pro Ile Pro Pro Tyr Val Leu Gly Ala Trp Leu Gly Asp Gly His Ser 
                245                 250                 255     


Ala Ser Ala Arg Ile Thr Cys Glu Thr Pro Glu Ile Pro Met Tyr Leu 
            260                 265                 270         


Glu Ala Cys Gly Leu Arg Val Asp His Gln Gly Ala Met Leu Tyr Ser 
        275                 280                 285             


Leu Lys Phe Pro Asp Gly Asp Pro Arg Gly Ser Val Gln Gly Val Leu 
    290                 295                 300                 


Arg Thr Ile Gly Val Leu Asn Asp Lys His Ile Pro Ala Asp Tyr Leu 
305                 310                 315                 320 


Arg Ala Ser Glu Gly Gln Arg Arg Asp Leu Leu Ala Gly Leu Met Asp 
                325                 330                 335     


Thr Asp Gly Thr Val Val Arg Gly Val Gly Ser Cys Gln Phe Ala Val 
            340                 345                 350         


Thr Asn Lys Arg Leu Ala Asp Asp Val Tyr Glu Leu Val Val Ser Leu 
        355                 360                 365             


Gly Tyr Lys Cys Gly Arg Thr Thr Arg Arg Val Gln Gly Arg Ser Pro 
    370                 375                 380                 


Glu Thr Ser Thr Cys His Ile Leu Asn Phe Ser Thr Val Asp Asp Val 
385                 390                 395                 400 


Phe Arg Leu Glu Arg Lys His Leu Leu His Lys Glu Glu Arg Pro Val 
                405                 410                 415     


Thr Arg Ala Arg Ile Ala Arg Arg Tyr Ile Thr Ala Val Arg Pro Ile 
            420                 425                 430         


Glu Ser Val Pro Val Arg Cys Val Glu Val Asp Asn Thr Glu His Leu 
        435                 440                 445             


Tyr Leu Ala Gly Glu Ser Met Ile Pro Thr His Asn Ser Gly Val Lys 
    450                 455                 460                 


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
465                 470                 475                 480 


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
                485                 490                 495     


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
            500                 505                 510         


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
        515                 520                 525             


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
    530                 535                 540                 


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
545                 550                 555                 560 


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
                565                 570                 575     


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
            580                 585                 590         


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
        595                 600                 605             


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
    610                 615                 620                 


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
625                 630                 635                 640 


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
                645                 650                 655     


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
            660                 665                 670         


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
        675                 680                 685             


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
    690                 695                 700                 


Thr Arg 
705     


<210>  217
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Nsp-PCC7120_RIR1

<400>  217

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Pro Glu 
            100                 105                 110         


Asp Ala Leu Val His Thr Ala Lys Gly Leu Val Pro Ile Arg Asp Val 
        115                 120                 125             


Gln Val Gly Asp Leu Val Gln Thr Pro Leu Gly Phe Arg Arg Val Val 
    130                 135                 140                 


Asp Lys Phe Asp Gln Gly Phe Gln Asp Val Tyr Glu Ile Glu Thr Asn 
145                 150                 155                 160 


Ala Thr Tyr Pro Arg Ala Thr Leu Asn His Arg Gln Ala Val Leu Glu 
                165                 170                 175     


Asp Ala Lys Gly Gly Ile Val Trp Lys His Ile Ala Ser Leu Glu Ala 
            180                 185                 190         


Gly Asp Arg Leu Leu His Asn Lys Gln Val Leu Pro Gly Thr Val Thr 
        195                 200                 205             


His Leu Pro Ala Asp Phe Thr Glu Ser Arg Pro Ser His Ser Arg Thr 
    210                 215                 220                 


Ala Lys Ser Phe Val Val Pro Glu Leu Thr Ala Glu Val Ala Trp Leu 
225                 230                 235                 240 


Ile Gly Phe Thr His Gly Asp Gly Tyr Val Ala Leu Gly Arg Asn Lys 
                245                 250                 255     


Tyr Asp Lys Pro Tyr Gly Arg Val Glu Trp Ser Met Asn Ser Leu Asp 
            260                 265                 270         


Ala Glu Val Thr Ser Arg Ile Gln Ala Lys Ile Asp Ala Ala Leu Ala 
        275                 280                 285             


Leu Phe Gly Leu Ser Ala Val His Ser Ile Thr Lys Gly Glu Asn Thr 
    290                 295                 300                 


Ala Lys Ser Ile Cys Ser Ser Ile Arg Leu Ala Glu Tyr Phe His Arg 
305                 310                 315                 320 


His Ile Lys Gln Pro Asn Ile Pro Leu Thr Val Pro Ser Phe Ile Leu 
                325                 330                 335     


Gln Gly Ser Val Asp Ile Arg Ala Ala Tyr Leu Ala Gly Leu Met Asp 
            340                 345                 350         


Ser Asp Gly Ala Val Asn Asn Arg Pro Pro His Leu Ile Thr Ser Val 
        355                 360                 365             


Tyr Arg Ser Phe Ile Arg Gln Val Ser Val Val Leu Ser Ser Leu Gly 
    370                 375                 380                 


Ile Ala Gly Arg Leu Thr Thr Thr Tyr Pro Gln Asn Ser Asn Trp Gln 
385                 390                 395                 400 


Val Lys Tyr Asn Leu Thr Ile Pro Ala Leu Lys Glu Arg Tyr Asn Ala 
                405                 410                 415     


Leu Ile Ser Pro His Ser Ala Lys Gly Glu Leu Arg Gln Gly Leu Lys 
            420                 425                 430         


Met Tyr Gly Phe Thr Val Pro Gly Ala Val Met Arg Glu Thr Tyr Thr 
        435                 440                 445             


Tyr Ser Glu Met Arg Glu Met Gly Phe Gln Gly Ser Arg Thr Val Asp 
    450                 455                 460                 


Ala Asn Tyr Glu Arg Tyr Val Ala Glu Ala Asp Ile Ser Leu Asp Ile 
465                 470                 475                 480 


Pro Val Thr Val Lys Gly Leu Gly Ser Tyr Asp His Val Gln Thr Tyr 
                485                 490                 495     


Asp Ile Glu Val Asp Glu Ala His Cys Phe Tyr Cys Asp Gly Tyr Leu 
            500                 505                 510         


Thr His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser 
        515                 520                 525             


Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly 
    530                 535                 540                 


Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly 
545                 550                 555                 560 


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro 
                565                 570                 575     


Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly 
            580                 585                 590         


Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly 
        595                 600                 605             


Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr 
    610                 615                 620                 


Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val 
625                 630                 635                 640 


Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg 
                645                 650                 655     


Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg 
            660                 665                 670         


Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly 
        675                 680                 685             


Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn 
    690                 695                 700                 


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
705                 710                 715                 720 


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
                725                 730                 735     


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
            740                 745                 750         


Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760     


<210>  218
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_CDC21-1

<400>  218

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Asp Tyr 
            100                 105                 110         


Glu Thr Glu Val Val Leu Gly Asn Gly Glu Arg Lys Lys Ile Gly Glu 
        115                 120                 125             


Ile Val Glu Arg Ala Ile Glu Glu Ala Glu Lys Asn Gly Lys Leu Gly 
    130                 135                 140                 


Arg Val Asp Asp Gly Phe Tyr Ala Pro Ile Asp Ile Glu Val Tyr Ser 
145                 150                 155                 160 


Leu Asp Leu Glu Thr Leu Lys Val Arg Lys Ala Arg Ala Asn Ile Ala 
                165                 170                 175     


Trp Lys Arg Thr Ala Pro Lys Lys Met Met Leu Val Lys Thr Arg Gly 
            180                 185                 190         


Gly Lys Arg Ile Arg Val Thr Pro Thr His Pro Phe Phe Val Leu Glu 
        195                 200                 205             


Glu Gly Lys Val Ala Met Arg Lys Ala Arg Asp Leu Glu Glu Gly Asn 
    210                 215                 220                 


Lys Ile Ala Thr Ile Glu Gly Leu Ser Val Ser Trp Asp Glu Val Ala 
225                 230                 235                 240 


Glu Ile Leu Glu Tyr Glu Pro Lys Asp Pro Trp Val Tyr Asp Leu Gln 
                245                 250                 255     


Val Pro Gly Tyr His Asn Phe Leu Ala Asn Gly Ile Phe Val His Asn 
            260                 265                 270         


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
        275                 280                 285             


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
    290                 295                 300                 


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
305                 310                 315                 320 


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
                325                 330                 335     


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
            340                 345                 350         


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
        355                 360                 365             


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
    370                 375                 380                 


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
385                 390                 395                 400 


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
                405                 410                 415     


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
            420                 425                 430         


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
        435                 440                 445             


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
    450                 455                 460                 


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
465                 470                 475                 480 


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
                485                 490                 495     


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
            500                 505                 510         


Ala Glu Ala Ala Thr Arg 
        515             


<210>  219
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_CDC21-2

<400>  219

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ala Pro 
            100                 105                 110         


Glu Thr Leu Ile Ile Thr Glu Asn Gly Thr Lys Glu Ile Gly Glu Val 
        115                 120                 125             


Val Glu Arg Trp Met Lys Glu Leu Gly Glu Ile Glu Tyr Asp Asp Gly 
    130                 135                 140                 


Ile Ser Tyr Ser Pro Ala Phe Glu Lys Val Ala Ser Leu Asn Gly Gly 
145                 150                 155                 160 


Lys Val Lys Met Leu Pro Val Arg Arg Val Trp Lys Leu Arg Ser Pro 
                165                 170                 175     


Gly Lys Met Ile Lys Ile Arg Ser Glu Ser Gly Lys Gln Ile Thr Val 
            180                 185                 190         


Thr Pro Glu Thr Lys Leu Leu Thr Ile Ile Asp Gly Ser Leu Glu Trp 
        195                 200                 205             


Val Glu Ala Arg Lys Leu Lys Lys Gly Asn Tyr Val Ala Val Val Asn 
    210                 215                 220                 


Lys Glu Arg Ser Ile Val Pro Ile Gly Asp Phe Leu Ala Lys Leu Leu 
225                 230                 235                 240 


Lys Phe Tyr Gly Val Glu Leu Asn Leu Asn Glu Ala Val Glu Arg Asp 
                245                 250                 255     


Gln Ala Arg Lys Leu Leu Glu Thr Leu Lys Ser Lys Gly Leu Ser Asp 
            260                 265                 270         


Val Thr Ile Glu Ile Pro Glu Lys Leu Arg Arg Phe Ile Lys Cys Asp 
        275                 280                 285             


Arg Val Arg Tyr Val Asp Leu Val Glu Met Leu Ser Ser Met Glu Gly 
    290                 295                 300                 


Glu Leu Lys Glu Glu Val Met Leu Leu Leu Ser Asp Val Gly Asp Ile 
305                 310                 315                 320 


His Glu Val Ile Gln Glu Arg Leu Lys Glu Ile Gly Lys Ile Leu Glu 
                325                 330                 335     


Ser Asp Ala Ser Trp Glu Arg Ile Ala Glu Val Glu Glu Val Val Arg 
            340                 345                 350         


Asp Gly His Val Tyr Asp Leu Thr Val Glu Gly Ser His Ser Phe Ile 
        355                 360                 365             


Ala Asn Gly Phe Val Val His Asn Ser Gly Val Lys Val Ala Val Leu 
    370                 375                 380                 


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
385                 390                 395                 400 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
                405                 410                 415     


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
            420                 425                 430         


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
        435                 440                 445             


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
    450                 455                 460                 


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
465                 470                 475                 480 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
                485                 490                 495     


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
            500                 505                 510         


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
        515                 520                 525             


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
    530                 535                 540                 


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
545                 550                 555                 560 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
                565                 570                 575     


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
            580                 585                 590         


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
        595                 600                 605             


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    610                 615                 620         


<210>  220
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_IF2

<400>  220

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Leu Pro 
            100                 105                 110         


Asp Glu Lys Val Val Val Pro Ser Val Gly Phe Val Thr Leu Lys Glu 
        115                 120                 125             


Leu Phe Glu Thr Ala Ser Lys Val Val Glu Arg Asp Asp Glu Lys Glu 
    130                 135                 140                 


Ile Arg Glu Leu Asp Glu Arg Ile Thr Ser Val Asn Gly Asp Gly Lys 
145                 150                 155                 160 


Thr Gly Leu Val Lys Ala Ser Tyr Val Trp Lys Val Arg His Lys Gly 
                165                 170                 175     


Lys Val Ile Arg Val Lys Leu Lys Asn Trp His Gly Val Thr Val Thr 
            180                 185                 190         


Pro Glu His Pro Phe Leu Thr Thr Lys Gly Trp Lys Arg Ala Asp Gln 
        195                 200                 205             


Leu Arg Pro Gly Asp Tyr Val Ala Val Pro Arg Phe Ile His Gly Asn 
    210                 215                 220                 


Glu Asp Glu Lys Ile Phe Leu Ser Tyr Val Lys Val Lys Lys Ser Gly 
225                 230                 235                 240 


Glu Glu Trp Lys Glu Tyr Phe Tyr Leu Ala Gly Arg Lys Gly Asn Ile 
                245                 250                 255     


Asp Val Asn Leu Leu Phe Val Ala Pro Lys Arg Tyr Val Val Glu Phe 
            260                 265                 270         


Leu Arg Gly Tyr Phe Glu Glu Arg Ser Glu Val Lys Gly Glu Ser Val 
        275                 280                 285             


Ile Val Glu Ala Arg Glu Leu Val Glu Pro Leu Ser Leu Ala Leu Leu 
    290                 295                 300                 


Arg Phe Gly Ile Phe Ser Lys Ile Gln Gly Ser Lys Leu Ile Val Thr 
305                 310                 315                 320 


Gly Lys Arg Asn Leu Glu Ala Phe Lys Asp Tyr Ile Gly Phe Lys Asp 
                325                 330                 335     


Glu Arg Glu Lys Ala Leu Glu Glu Ala Ile Glu Lys Val Lys Gly Ser 
            340                 345                 350         


Glu Val Tyr Pro Ile Phe Glu Glu Ile Arg Arg Leu Arg Leu Leu Phe 
        355                 360                 365             


Gly Phe Thr Arg Glu Glu Leu Gly Ser Tyr Ala Lys Tyr Glu Asn Ser 
    370                 375                 380                 


Glu Ala Pro Thr Tyr Glu Glu Leu Met Glu Ile Leu Asp Phe Ile Glu 
385                 390                 395                 400 


Arg Gly Ser Pro Ser Leu Ser Lys Lys Ile Ala Ile Leu Glu Gly Lys 
                405                 410                 415     


Leu Lys Ala Glu Leu Arg Val Leu Glu Glu Glu Gly Leu Ile Lys Asp 
            420                 425                 430         


Gly Lys Leu Thr Pro Leu Gly Arg Glu Leu Leu Glu Val Trp Arg Asn 
        435                 440                 445             


Arg Glu Phe Asp Ser Lys Asp Val Asp Tyr Ile Arg Asn Ile Ala Glu 
    450                 455                 460                 


Thr Leu Val Phe Ile Pro Val Glu Asn Val Glu Glu Glu Glu Tyr Asp 
465                 470                 475                 480 


Gly Tyr Val Tyr Asp Leu Thr Thr Glu Thr His Asn Phe Ile Ala Asn 
                485                 490                 495     


Gly Ile Leu Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
            500                 505                 510         


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
        515                 520                 525             


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
    530                 535                 540                 


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
545                 550                 555                 560 


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
                565                 570                 575     


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
            580                 585                 590         


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
        595                 600                 605             


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
    610                 615                 620                 


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
625                 630                 635                 640 


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
                645                 650                 655     


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
            660                 665                 670         


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
        675                 680                 685             


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
    690                 695                 700                 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
705                 710                 715                 720 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
                725                 730                 735     


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            740                 745             


<210>  221
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_KlbA

<400>  221

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ala Leu Tyr Tyr 
            100                 105                 110         


Phe Ser Glu Ile Gln Leu Pro Asn Gly Lys Glu Phe Ile Gly Lys Leu 
        115                 120                 125             


Val Asp Glu Leu Phe Glu Lys Tyr His Asp Lys Ile Gly Lys Tyr Lys 
    130                 135                 140                 


Asp Met Glu Tyr Val Glu Leu Asn Glu Glu Asp Thr Phe Glu Val Ile 
145                 150                 155                 160 


Ser Ile Gly Pro Asp Leu Ser Ala Arg Arg His Lys Val Thr His Val 
                165                 170                 175     


Trp Arg Arg Lys Val Lys Asp Gly Glu Lys Leu Val Lys Ile Arg Thr 
            180                 185                 190         


Ala Ser Gly Lys Glu Leu Val Leu Thr Gln Asp His Pro Val Phe Val 
        195                 200                 205             


Leu Leu Gly Arg Asp Val Ala Arg Arg Asp Ala Gly Asn Val Lys Val 
    210                 215                 220                 


Gly Asp Glu Ile Ala Val Leu Asn Thr Arg Pro Asp Phe Ser Val Leu 
225                 230                 235                 240 


Ser Pro Pro Ala Met Pro Glu Leu Leu Ser Glu Pro Phe Asn Tyr Glu 
                245                 250                 255     


Leu Ser Ser Ile Gly Asp Val Ala Trp Asp Glu Val Val Glu Val Asp 
            260                 265                 270         


Glu Ile Asp Ala Lys Gly Leu Gly Val Glu Tyr Leu Tyr Asp Leu Thr 
        275                 280                 285             


Val Asp Ile Asn His Asn Tyr Val Ala Asn Gly Ile Val Val Ser Asn 
    290                 295                 300                 


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
305                 310                 315                 320 


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
                325                 330                 335     


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
            340                 345                 350         


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
        355                 360                 365             


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
    370                 375                 380                 


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
385                 390                 395                 400 


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
                405                 410                 415     


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
            420                 425                 430         


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
        435                 440                 445             


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
    450                 455                 460                 


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
465                 470                 475                 480 


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
                485                 490                 495     


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
            500                 505                 510         


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
        515                 520                 525             


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
    530                 535                 540                 


Ala Glu Ala Ala Thr Arg 
545                 550 


<210>  222
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_Lon

<400>  222

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ser Gly 
            100                 105                 110         


Glu Glu Thr Val Val Ile Arg Glu Asn Gly Glu Val Lys Val Leu Arg 
        115                 120                 125             


Leu Lys Asp Phe Val Glu Lys Ala Leu Glu Lys Pro Ser Gly Glu Gly 
    130                 135                 140                 


Leu Asp Gly Asp Val Lys Val Val Tyr His Asp Phe Arg Asn Glu Asn 
145                 150                 155                 160 


Val Glu Val Leu Thr Lys Asp Gly Phe Thr Lys Leu Leu Tyr Ala Asn 
                165                 170                 175     


Lys Arg Ile Gly Lys Gln Lys Leu Arg Arg Val Val Asn Leu Glu Lys 
            180                 185                 190         


Asp Tyr Trp Phe Ala Leu Thr Pro Asp His Lys Val Tyr Thr Thr Asp 
        195                 200                 205             


Gly Leu Lys Glu Ala Gly Glu Ile Thr Glu Lys Asp Glu Leu Ile Ser 
    210                 215                 220                 


Val Pro Ile Thr Val Phe Asp Cys Glu Asp Glu Asp Leu Lys Lys Ile 
225                 230                 235                 240 


Gly Leu Leu Pro Leu Thr Ser Asp Asp Glu Arg Leu Arg Lys Ile Ala 
                245                 250                 255     


Thr Leu Met Gly Ile Leu Phe Asn Gly Gly Ser Ile Asp Glu Gly Leu 
            260                 265                 270         


Gly Val Leu Thr Leu Lys Ser Glu Arg Ser Val Ile Glu Lys Phe Val 
        275                 280                 285             


Ile Thr Leu Lys Glu Leu Phe Gly Lys Phe Glu Tyr Glu Ile Ile Lys 
    290                 295                 300                 


Glu Glu Asn Thr Ile Leu Lys Thr Arg Asp Pro Arg Ile Ile Lys Phe 
305                 310                 315                 320 


Leu Val Gly Leu Gly Ala Pro Ile Glu Gly Lys Asp Leu Lys Met Pro 
                325                 330                 335     


Trp Trp Val Lys Leu Lys Pro Ser Leu Phe Leu Ala Phe Leu Glu Gly 
            340                 345                 350         


Phe Arg Ala His Ile Val Glu Gln Leu Val Asp Asp Pro Asn Lys Asn 
        355                 360                 365             


Leu Pro Phe Phe Gln Glu Leu Ser Trp Tyr Leu Gly Leu Phe Gly Ile 
    370                 375                 380                 


Lys Ala Asp Ile Lys Val Glu Glu Val Gly Asp Lys His Lys Ile Ile 
385                 390                 395                 400 


Phe Asp Ala Gly Arg Leu Asp Val Asp Lys Gln Phe Ile Glu Thr Trp 
                405                 410                 415     


Glu Asp Val Glu Val Thr Tyr Asn Leu Thr Thr Glu Lys Gly Asn Leu 
            420                 425                 430         


Leu Ala Asn Gly Leu Phe Val Lys Asn Ser Gly Val Lys Val Ala Val 
        435                 440                 445             


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
    450                 455                 460                 


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
465                 470                 475                 480 


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
                485                 490                 495     


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
            500                 505                 510         


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
        515                 520                 525             


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
    530                 535                 540                 


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
545                 550                 555                 560 


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
                565                 570                 575     


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
            580                 585                 590         


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
        595                 600                 605             


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
    610                 615                 620                 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
625                 630                 635                 640 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
                645                 650                 655     


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
            660                 665                 670         


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680                 685         


<210>  223
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_Moaa

<400>  223

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Pro Pro 
            100                 105                 110         


Thr Glu Glu Ala Val Phe Lys Phe Gly Asp Lys Val Lys Ile Ala Thr 
        115                 120                 125             


Phe Glu Glu Val Ala Lys Asn Phe Lys Phe Glu His Lys Val Glu Ile 
    130                 135                 140                 


Asp Gly Phe Lys Gly Glu Tyr Ser Ile Pro Asn Asp Leu Tyr Val Leu 
145                 150                 155                 160 


Thr Phe Asn Asp Gly Lys Ala Glu Trp Thr Arg Val Thr Lys Phe Leu 
                165                 170                 175     


Arg Arg Lys His Glu Gly Lys Ile Arg Val Ile Lys Thr Lys Thr Gly 
            180                 185                 190         


Arg Thr Ile Arg Thr Thr Pro Glu His Lys Phe Phe Val Tyr Lys Asp 
        195                 200                 205             


Gly Glu Leu Val Lys Lys Arg Ala Asp Glu Leu Glu Pro Gly Asp Glu 
    210                 215                 220                 


Leu Val Leu Leu Trp Arg Phe Glu Ser Glu Glu Thr Leu Thr Glu Ile 
225                 230                 235                 240 


Asn Leu Leu Glu Ala Phe Lys Asp Leu Pro Gln Glu Glu Lys Glu Lys 
                245                 250                 255     


Val Tyr Val Arg Gly Ile Lys Asp Leu Asp Leu Thr Pro Leu Lys Glu 
            260                 265                 270         


Lys Tyr Gly Asp Lys Val Tyr Tyr Trp Ala Arg Gln Asp Ser Met Pro 
        275                 280                 285             


Leu Ser Val Phe Tyr Glu Leu Asn Val Asp Leu Asp Lys Glu Phe Arg 
    290                 295                 300                 


Leu Gly Arg Asp Ala Thr Thr Tyr Glu Leu Pro Ser Lys Leu Lys Ile 
305                 310                 315                 320 


Thr Pro Ser Leu Ala Lys Leu Ile Gly Tyr Phe Val Ser Asp Gly Asn 
                325                 330                 335     


Tyr Ser Asp Lys Asp Leu Arg Ile Thr Val Gly His Glu Asp Val Glu 
            340                 345                 350         


Lys Glu Ile Val Asn Ile Leu Glu Glu Leu Gly Leu Pro Tyr Ser Phe 
        355                 360                 365             


Leu Glu Trp Glu Gly Lys Thr Lys Gln Ile Val Ile Gly Ser Arg Leu 
    370                 375                 380                 


Leu Arg Leu Val Phe Lys His Val Phe Lys Ile Pro Glu Gly Ala Pro 
385                 390                 395                 400 


Asn Lys Arg Leu Pro Glu Gly Phe Leu Ser Phe Pro Phe Glu Ala Lys 
                405                 410                 415     


Val Ala Leu Leu Ser Gly Leu Phe Asn Gly Asp Gly Tyr Val Val Arg 
            420                 425                 430         


Gly Glu His His Leu Ser Ile Gly Tyr Ala Ser Thr Ser Lys Gly Leu 
        435                 440                 445             


Ile Arg Asp Ile Leu Tyr Leu Leu Ala Ser Leu Gly Ile Phe Ala Arg 
    450                 455                 460                 


Val Tyr Arg Val Pro Lys Glu Lys Met Lys Gly Ala Asn His Asp Leu 
465                 470                 475                 480 


Tyr Lys Leu Tyr Ile Ala Gly Thr Asp Leu Val Arg Leu Val Glu Leu 
                485                 490                 495     


Leu Glu Leu Arg Glu Gly His Arg Glu Lys Leu Gly Glu Ile Gly Asn 
            500                 505                 510         


Arg Lys Pro Ala Arg Val Lys Lys Ile Ala Asp Phe Tyr Ile Asp Val 
        515                 520                 525             


Val Asp Glu Val Ser Glu Glu Glu Tyr Ser Gly Tyr Val Tyr Asp Leu 
    530                 535                 540                 


Glu Val Glu Asn Glu Gly His Ser Phe Val Ala Ala Asp Gly Ile Leu 
545                 550                 555                 560 


Val Ser Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser 
                565                 570                 575     


Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly 
            580                 585                 590         


Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly 
        595                 600                 605             


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro 
    610                 615                 620                 


Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly 
625                 630                 635                 640 


Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly 
                645                 650                 655     


Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr 
            660                 665                 670         


Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val 
        675                 680                 685             


Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg 
    690                 695                 700                 


Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg 
705                 710                 715                 720 


Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly 
                725                 730                 735     


Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn 
            740                 745                 750         


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
        755                 760                 765             


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
    770                 775                 780                 


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
785                 790                 795                 800 


Leu Val Asn Ala Glu Ala Ala Thr Arg 
                805                 


<210>  224
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_Pol-II

<400>  224

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Pro Gly 
            100                 105                 110         


Asp Thr Arg Ile Leu Val Gln Ile Asp Gly Val Pro Gln Lys Ile Thr 
        115                 120                 125             


Leu Arg Glu Leu Tyr Glu Leu Phe Glu Asp Glu Arg Tyr Glu Asn Met 
    130                 135                 140                 


Val Tyr Val Arg Lys Lys Pro Lys Arg Glu Ile Lys Val Tyr Ser Ile 
145                 150                 155                 160 


Asp Leu Glu Thr Gly Lys Val Val Leu Thr Asp Ile Glu Asp Val Ile 
                165                 170                 175     


Lys Ala Pro Ala Thr Asp His Leu Ile Arg Phe Glu Leu Glu Asp Gly 
            180                 185                 190         


Arg Ser Phe Glu Thr Thr Val Asp His Pro Val Leu Val Tyr Glu Asn 
        195                 200                 205             


Gly Arg Phe Ile Glu Lys Arg Ala Phe Glu Val Lys Glu Gly Asp Lys 
    210                 215                 220                 


Val Leu Val Ser Glu Leu Glu Leu Val Glu Gln Ser Ser Ser Ser Gln 
225                 230                 235                 240 


Asp Asn Pro Lys Asn Glu Asn Leu Gly Ser Pro Glu His Asp Gln Leu 
                245                 250                 255     


Leu Glu Ile Lys Asn Ile Lys Tyr Val Arg Ala Asn Asp Asp Phe Val 
            260                 265                 270         


Phe Ser Leu Asn Ala Lys Lys Tyr His Asn Val Ile Ile Asn Glu Asn 
        275                 280                 285             


Ile Val Thr His Gln Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
    290                 295                 300                 


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
305                 310                 315                 320 


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
                325                 330                 335     


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
            340                 345                 350         


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
        355                 360                 365             


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
    370                 375                 380                 


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
385                 390                 395                 400 


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
                405                 410                 415     


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
            420                 425                 430         


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
        435                 440                 445             


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
    450                 455                 460                 


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
465                 470                 475                 480 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
                485                 490                 495     


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
            500                 505                 510         


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
        515                 520                 525             


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    530                 535                 


<210>  225
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_RFC-1

<400>  225

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Gly 
            100                 105                 110         


Asp Ala Lys Val Ile Ala Asn Gly Glu Leu Thr Thr Ile Gly Glu Leu 
        115                 120                 125             


Val Glu Arg Ile Ser Asn Gly Lys Leu Gly Pro Thr Pro Val Arg Gly 
    130                 135                 140                 


Leu Thr Val Leu Gly Ile Asp Glu Asp Gly Lys Leu Val Glu Leu Pro 
145                 150                 155                 160 


Val Glu Tyr Val Tyr Lys Asp Lys Thr Ser Glu Leu Val Lys Ile Arg 
                165                 170                 175     


Thr Arg Leu Gly Arg Glu Leu Lys Val Thr Pro Tyr His Pro Leu Leu 
            180                 185                 190         


Val Asn Arg Arg Asn Gly Lys Ile Glu Trp Val Lys Ala Glu Glu Leu 
        195                 200                 205             


Lys Pro Gly Asp Arg Leu Ala Ile Pro Ser Phe Leu Pro Ala Met Leu 
    210                 215                 220                 


Asn Asp Asn Pro Leu Ala Glu Trp Leu Gly Tyr Phe Phe Gly Asn Gly 
225                 230                 235                 240 


Tyr Thr Asp Ser Glu Glu Arg Val Val Phe Glu Ser Lys Ser Lys Glu 
                245                 250                 255     


Leu Arg Lys Arg Phe Met Glu Leu Thr Arg Lys Leu Phe Gln Asp Ala 
            260                 265                 270         


Glu Ile Lys Glu Asp Ser Gly Lys Val Tyr Val Ser Ser Ser Glu Val 
        275                 280                 285             


Lys Arg Leu Val Lys Ser Leu Asn Lys Asp Ser Ile Pro Glu Gln Ala 
    290                 295                 300                 


Trp Lys Gly Leu Arg Ser Phe Leu Arg Ala Tyr Phe Asp Cys Asn Ala 
305                 310                 315                 320 


Glu Ile Lys Asp Lys Ile Ile Val Ser Thr Ala Gly Lys Glu Ile Ala 
                325                 330                 335     


Glu Gln Ile Ser Tyr Ala Leu Ala Gly Leu Gly Ile Val Ala Glu Val 
            340                 345                 350         


Asp Asp Lys Gly Ser Val Ile Ile Ser Asp Pro Glu Asn Val Ser Arg 
        355                 360                 365             


Phe Leu Asp Glu Ile Gly Phe Ser Val Glu Glu Lys Lys Glu Glu Ala 
    370                 375                 380                 


Lys Ala Leu Ile Lys Lys Ser Thr Leu Asn Leu Gly Ile Tyr Val Asp 
385                 390                 395                 400 


Lys Glu Leu Ile Ser Tyr Val Arg Glu Lys Leu Lys Leu Ser Phe Tyr 
                405                 410                 415     


Glu Asn Glu Thr Met Trp Ser Pro Glu Lys Ala Arg Glu Ile Ala Trp 
            420                 425                 430         


Lys Leu Met Lys Glu Ile Tyr Tyr Arg Leu Asp Glu Leu Glu Arg Phe 
        435                 440                 445             


Lys Lys Ala Leu Ser Lys Ser Val Ile Ile Asp Trp Ser Glu Val Glu 
    450                 455                 460                 


Lys Lys Lys Glu Glu Ile Ser Glu Lys Thr Gly Ile Ser Val Asn Glu 
465                 470                 475                 480 


Ile Leu Glu Tyr Ala Lys Gly Lys Arg Lys Pro Ser Leu Glu Glu Tyr 
                485                 490                 495     


Val Lys Ile Ala Lys Ala Leu Gly Val Glu Leu Lys Glu Thr Leu Glu 
            500                 505                 510         


Ala Ile Phe Thr Phe Gly Lys Lys Tyr Leu Gly Tyr Val Ile Ser Asp 
        515                 520                 525             


Glu Ile Glu Thr Leu Glu Glu Val Arg Lys Glu Glu Leu Lys Arg Leu 
    530                 535                 540                 


Lys Glu Leu Leu Asn Asp Glu Lys Leu Lys Lys Gly Val Ala Tyr Leu 
545                 550                 555                 560 


Ile Phe Leu Ala Gln Asn Glu Leu Leu Trp Asp Glu Ile Ile Glu Val 
                565                 570                 575     


Glu Lys Leu Lys Gly Asp Phe Val Ile Tyr Asp Leu His Val Pro Lys 
            580                 585                 590         


Tyr His Asn Phe Ile Gly Gly Asn Leu Pro Thr Val Leu His Asn Ser 
        595                 600                 605             


Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp 
    610                 615                 620                 


Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr 
625                 630                 635                 640 


Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala 
                645                 650                 655     


Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu 
            660                 665                 670         


Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser 
        675                 680                 685             


Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala 
    690                 695                 700                 


Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala 
705                 710                 715                 720 


Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly 
                725                 730                 735     


Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
            740                 745                 750         


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
        755                 760                 765             


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
    770                 775                 780                 


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
785                 790                 795                 800 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                805                 810                 815     


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            820                 825                 830         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        835                 840                 845             


Glu Ala Ala Thr Arg 
    850             


<210>  226
<211>  962
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_RFC-2

<400>  226

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Gly 
            100                 105                 110         


Asp Thr Lys Val Tyr Thr Pro Asp Glu Arg Glu Val Lys Ile Arg Asp 
        115                 120                 125             


Phe Met Asn Tyr Phe Glu Asn Gly Leu Ile Lys Glu Val Ser Asn Arg 
    130                 135                 140                 


Ile Gly Arg Asp Thr Val Ile Ala Ala Val Ser Phe Asn Ser Arg Ile 
145                 150                 155                 160 


Val Gly His Pro Val Tyr Arg Leu Thr Leu Glu Ser Gly Arg Ile Ile 
                165                 170                 175     


Glu Ala Thr Gly Asp His Met Phe Leu Thr Pro Glu Gly Trp Lys Gln 
            180                 185                 190         


Thr Tyr Asp Ile Lys Glu Gly Ser Glu Val Leu Val Lys Pro Thr Leu 
        195                 200                 205             


Glu Gly Thr Pro Tyr Glu Pro Asp Pro Arg Val Ile Ile Asp Ile Lys 
    210                 215                 220                 


Glu Phe Tyr Asn Phe Leu Glu Lys Ile Glu Arg Glu His Asn Leu Lys 
225                 230                 235                 240 


Pro Leu Lys Glu Ala Lys Thr Phe Arg Glu Leu Ile Thr Lys Asp Lys 
                245                 250                 255     


Glu Lys Ile Leu Arg Arg Ala Leu Glu Leu Arg Ala Glu Ile Glu Asn 
            260                 265                 270         


Gly Leu Thr Lys Arg Glu Ala Glu Ile Leu Glu Leu Ile Ser Ala Asp 
        275                 280                 285             


Thr Trp Ile Pro Arg Ala Glu Leu Glu Lys Lys Ala Arg Ile Ser Arg 
    290                 295                 300                 


Thr Arg Leu Asn Gln Ile Leu Gln Arg Leu Glu Lys Lys Gly Tyr Ile 
305                 310                 315                 320 


Glu Arg Arg Ile Glu Gly Arg Lys Gln Phe Val Arg Lys Ile Arg Asn 
                325                 330                 335     


Gly Lys Ile Leu Arg Asn Ala Met Asp Ile Lys Arg Ile Leu Glu Glu 
            340                 345                 350         


Glu Phe Gly Ile Lys Ile Ser Tyr Thr Thr Val Lys Lys Leu Leu Ser 
        355                 360                 365             


Gly Asn Val Asp Gly Met Ala Tyr Arg Ile Leu Lys Glu Val Lys Glu 
    370                 375                 380                 


Lys Trp Leu Val Arg Tyr Asp Asp Glu Lys Ala Gly Ile Leu Ala Arg 
385                 390                 395                 400 


Val Val Gly Phe Ile Leu Gly Asp Gly His Leu Ala Arg Asn Gly Arg 
                405                 410                 415     


Ile Trp Phe Asn Ser Ser Lys Glu Glu Leu Glu Met Leu Ala Asn Asp 
            420                 425                 430         


Leu Arg Lys Leu Gly Leu Lys Pro Ser Glu Ile Ile Glu Arg Asp Ser 
        435                 440                 445             


Ser Ser Glu Ile Gln Gly Arg Lys Val Lys Gly Arg Ile Tyr Met Leu 
    450                 455                 460                 


Tyr Val Asp Asn Ala Ala Phe His Ala Leu Leu Arg Phe Trp Lys Val 
465                 470                 475                 480 


Glu Val Gly Asn Lys Thr Lys Lys Gly Tyr Thr Val Pro Glu Trp Ile 
                485                 490                 495     


Lys Lys Gly Asn Leu Phe Val Lys Arg Glu Phe Leu Arg Gly Leu Phe 
            500                 505                 510         


Gly Ala Asp Gly Thr Lys Pro Cys Gly Lys Arg Tyr Asn Phe Asn Gly 
        515                 520                 525             


Ile Lys Leu Glu Ile Arg Ala Lys Lys Glu Ser Leu Glu Arg Thr Val 
    530                 535                 540                 


Glu Phe Leu Asn Asp Val Ala Asp Leu Leu Arg Glu Phe Asp Val Asp 
545                 550                 555                 560 


Ser Lys Ile Thr Val Ser Pro Thr Lys Glu Gly Phe Ile Ile Arg Leu 
                565                 570                 575     


Ile Val Thr Pro Asn Asp Ala Asn Tyr Leu Asn Phe Leu Thr Arg Val 
            580                 585                 590         


Gly Tyr Ala Tyr Ala Lys Asp Thr Tyr Ala Arg Leu Val Gly Glu Tyr 
        595                 600                 605             


Ile Arg Ile Lys Leu Ala Tyr Lys Asn Ile Ile Leu Pro Gly Ile Ala 
    610                 615                 620                 


Glu Lys Ala Ile Glu Leu Ala Thr Val Thr Asn Ser Thr Tyr Ala Ala 
625                 630                 635                 640 


Lys Val Leu Gly Val Ser Arg Asp Phe Val Val Asn Arg Leu Lys Gly 
                645                 650                 655     


Thr Gln Ile Gly Ile Thr Arg Asp Phe Met Thr Phe Glu Glu Phe Met 
            660                 665                 670         


Lys Glu Arg Val Leu Asn Gly Tyr Val Ile Glu Lys Val Ile Lys Lys 
        675                 680                 685             


Glu Lys Leu Gly Tyr Leu Asp Val Tyr Asp Val Thr Cys Ala Arg Asp 
    690                 695                 700                 


His Ser Phe Ile Ser Asn Gly Leu Val Ser His Asn Ser Gly Val Lys 
705                 710                 715                 720 


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
                725                 730                 735     


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
            740                 745                 750         


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
        755                 760                 765             


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
    770                 775                 780                 


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
785                 790                 795                 800 


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
                805                 810                 815     


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
            820                 825                 830         


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
        835                 840                 845             


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
    850                 855                 860                 


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
865                 870                 875                 880 


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
                885                 890                 895     


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
            900                 905                 910         


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
        915                 920                 925             


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
    930                 935                 940                 


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
945                 950                 955                 960 


Thr Arg 
        


<210>  227
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_RIR1-1

<400>  227

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Ile Asp Gly 
            100                 105                 110         


Asn Ala Lys Ile Ile Phe Glu Asn Glu Gly Glu Glu His Leu Thr Thr 
        115                 120                 125             


Met Ala Glu Met Tyr Glu Arg Tyr Arg His Leu Gly Glu Phe Tyr Asp 
    130                 135                 140                 


Glu Asn Tyr Asn Arg Trp Gly Ile Asp Val Ser Ser Val Pro Ile Tyr 
145                 150                 155                 160 


Val Lys Ser Phe Asp Pro Glu Thr Arg Arg Val Val Lys Gly Arg Val 
                165                 170                 175     


Arg Ala Ile Trp Lys Tyr Glu Leu Gly Glu Glu Ile Pro Lys Tyr Glu 
            180                 185                 190         


Ile Arg Thr His Lys Gly Thr Lys Ile Leu Thr Ser Pro Trp His Pro 
        195                 200                 205             


Phe Phe Val Leu Thr Pro Asp Phe Glu Val Ile Glu Lys Arg Ala Asp 
    210                 215                 220                 


Glu Leu Lys Val Gly Asp Ile Leu Ile Gly Gly Met Pro Asp Gly Glu 
225                 230                 235                 240 


Asp His Glu Leu Ile Phe Asp Tyr Trp Leu Ala Gly Phe Ile Ala Gly 
                245                 250                 255     


Asn Gly Asn Leu Asp Asp Ser Glu Arg Glu Tyr Lys Ala Arg Glu Leu 
            260                 265                 270         


Leu Asp Gly Ile Glu Asn Gly Ile Pro Pro Lys Ile Leu Arg Lys Gly 
        275                 280                 285             


Lys Asn Ala Val Leu Ser Phe Ile Thr Gly Leu Phe Asp Ala Glu Gly 
    290                 295                 300                 


His Val Asn Asp Lys Ser Gly Ile Glu Leu Gly Met Val Asn Lys Lys 
305                 310                 315                 320 


Leu Ile Glu Ala Val Thr His Tyr Leu Asn Ser Leu Gly Ile Lys Ala 
                325                 330                 335     


Arg Met Arg Glu Lys Arg Arg Lys Asn Gly Ile Asp Tyr Ile Met His 
            340                 345                 350         


Val Glu Glu Tyr Ser Ser Leu Leu Arg Phe Tyr Glu Leu Ile Gly Lys 
        355                 360                 365             


His Leu Gln Asn Asn Glu Lys Lys Glu Lys Leu Glu Ile Leu Leu His 
    370                 375                 380                 


Lys His Asn Gly Gly Ala Phe Asp Leu Ser Leu Asn Phe Asn Ala Phe 
385                 390                 395                 400 


Lys Glu Trp Ala Ser Arg Tyr Gly Val Glu Phe Lys Thr Asn Gly Asn 
                405                 410                 415     


Gln Ile Leu Ala Ile Ile Gly Asn Glu Lys Val Ser Leu Gly Gln Trp 
            420                 425                 430         


His Ala Arg Gly His Val Ser Lys Ala Val Leu Val Lys Met Leu Arg 
        435                 440                 445             


Lys Leu Tyr Glu Val Thr Lys Asn Asp Glu Val Lys Glu Met Leu His 
    450                 455                 460                 


Leu Ile Glu Ser Leu Glu Val Val Lys Glu Ile Thr Ile Thr Asn Glu 
465                 470                 475                 480 


Pro Lys Thr Phe Tyr Asp Leu Thr Val Asp Lys Tyr Gln Asn Tyr Leu 
                485                 490                 495     


Ala Gly Glu Asn Gly Met Ile Phe Val His Asn Ser Gly Val Lys Val 
            500                 505                 510         


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
        515                 520                 525             


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
    530                 535                 540                 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
545                 550                 555                 560 


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
                565                 570                 575     


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
            580                 585                 590         


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
        595                 600                 605             


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
    610                 615                 620                 


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
625                 630                 635                 640 


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
                645                 650                 655     


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
            660                 665                 670         


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
        675                 680                 685             


Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
    690                 695                 700                 


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
705                 710                 715                 720 


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
                725                 730                 735     


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
            740                 745                 750         


Arg 
    


<210>  228
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_RIR1-2

<400>  228

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Thr Gly 
            100                 105                 110         


Asp Thr Arg Ile Leu Thr Glu Lys Gly Leu Ile Pro Ile Glu Glu Ile 
        115                 120                 125             


Val His Glu Thr Gly Lys Lys Pro Lys Val Val Thr His Ala Gly Leu 
    130                 135                 140                 


Lys Asp Ile Ile Glu Thr Tyr Asp Asn Gly Glu Met Glu Val Phe Arg 
145                 150                 155                 160 


Val Thr Thr Glu Asp Gly Tyr Glu Leu Lys Val Thr Gly Asp His Lys 
                165                 170                 175     


Phe Leu Val Phe Asp Glu Asn Gly Asn Pro Thr Leu Lys Pro Leu Lys 
            180                 185                 190         


Glu Leu Lys Val Gly Asp Tyr Val Tyr Ile Leu Ala Pro Glu Trp Lys 
        195                 200                 205             


Gly Gly Glu Tyr Val Glu Leu Asp Thr Asn Ile Glu Leu Lys Gly Lys 
    210                 215                 220                 


Gly Tyr Asn Val Asn Leu Pro Ser Lys Leu Asp Glu Lys Leu Ala Tyr 
225                 230                 235                 240 


Leu Leu Gly Ile Ile Tyr Ala Asp Gly His Ile Arg His Tyr Phe Glu 
                245                 250                 255     


Asn Gly Lys Arg Lys Asn Ser Lys Ile Glu Ile Tyr Leu His Gln Asp 
            260                 265                 270         


Glu Thr Glu Ile Lys Glu Lys Val Lys Arg Tyr Phe Lys Glu Ile Phe 
        275                 280                 285             


Gly Ile Glu Pro Lys Glu Phe Leu Lys Glu Glu Gln His Lys Val Ile 
    290                 295                 300                 


Leu Val Ile Pro Ser Thr Lys Ile Val Lys Phe Leu Glu Ile Asn Gly 
305                 310                 315                 320 


Leu Leu Lys Asp Lys Ser Glu Asn Ile Arg Val Pro Glu Ala Ile Phe 
                325                 330                 335     


Arg Ser Arg Pro Ser Val Ile Ala Ala Phe Leu Ala Gly Phe Phe Asp 
            340                 345                 350         


Gly Asp Gly Ser Ile Asp Gln Asn Tyr Arg Ile Ala Phe Lys Ser Ile 
        355                 360                 365             


Ser Arg Glu Phe Ile Lys Glu Ala Gln Leu Leu Phe Leu Ala Leu Gly 
    370                 375                 380                 


Ile Val Thr Ser Ile Gln Glu Tyr Asn Pro Pro Asn Pro Asn Asn Lys 
385                 390                 395                 400 


Thr Val Tyr Thr Leu Arg Val Gln Thr Arg Asp Met Lys Ile Lys Ala 
                405                 410                 415     


Phe Asn Val Leu Lys Glu Ser Val Lys Leu Ser Lys Ile Met Lys Glu 
            420                 425                 430         


Ala Ile Ser Lys Leu Glu Glu Asn Gly Lys Asn Lys Lys Phe Ser Phe 
        435                 440                 445             


Pro Phe Asn Ala Ile Tyr His Ile Lys Asp Pro Lys Ile Arg Ala Lys 
    450                 455                 460                 


Ile Gln Arg Asp Tyr Lys Ile Leu Ser Tyr Asn Ser Lys Val Thr His 
465                 470                 475                 480 


Arg Ala Phe Ile Asn Asn Ile Leu Lys Leu Lys Glu Glu Leu Gly Leu 
                485                 490                 495     


Asp Asp Glu Glu Val Lys Tyr Phe Glu Met Leu Ser Lys Leu Tyr Pro 
            500                 505                 510         


Thr Lys Ile Thr Lys Ile Glu Pro Leu Gly Lys Ala His Val Tyr Asp 
        515                 520                 525             


Leu Gln Val Glu Asp Val His Leu Leu Thr Gly Asn Gly Ile Tyr Thr 
    530                 535                 540                 


Ser Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
545                 550                 555                 560 


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
                565                 570                 575     


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
            580                 585                 590         


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
        595                 600                 605             


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
    610                 615                 620                 


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
625                 630                 635                 640 


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
                645                 650                 655     


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
            660                 665                 670         


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
        675                 680                 685             


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
    690                 695                 700                 


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
705                 710                 715                 720 


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
                725                 730                 735     


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            740                 745                 750         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        755                 760                 765             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    770                 775                 780                 


Val Asn Ala Glu Ala Ala Thr Arg 
785                 790         


<210>  229
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_RIR1-3

<400>  229

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Val Gly 
            100                 105                 110         


Glu Thr Arg Ile Leu Thr Pro Glu Gly Tyr Ile Lys Ala Glu Glu Leu 
        115                 120                 125             


Phe Lys Leu Ala Lys Glu Arg Gly Lys Met Glu Ala Ile Ala Val Glu 
    130                 135                 140                 


Gly Ile Ala Glu Gly Gly Glu Pro Tyr Ala Tyr Ser Leu Glu Ile Leu 
145                 150                 155                 160 


Leu Pro Gly Asp Lys Gln Val Lys Tyr Glu Thr Val His Gly Asn Ala 
                165                 170                 175     


Val Glu Val Ala Asp Pro Val Ser Val Pro Ala Tyr Val Trp Lys Val 
            180                 185                 190         


Gly Met Lys Glu Val Ala Arg Val Arg Thr Lys Glu Gly Tyr Glu Ile 
        195                 200                 205             


Thr Ala Thr Leu Asp His Lys Leu Met Thr Pro Glu Gly Trp Lys Glu 
    210                 215                 220                 


Ile Lys Asp Leu Lys Pro Gly Asp Lys Ile Leu Leu Pro Arg Phe Glu 
225                 230                 235                 240 


Val Glu Glu Asp Phe Gly Ser Glu Ser Ile Gly Glu Asp Leu Ala Phe 
                245                 250                 255     


Val Leu Gly Trp Phe Ile Gly Asp Gly Tyr Leu Asn Val Lys Asp Lys 
            260                 265                 270         


Arg Ala Trp Phe Tyr Phe Asn Ala Glu Lys Glu Glu Glu Ile Ala Trp 
        275                 280                 285             


Lys Ile Arg Glu Ile Leu Ala Lys Arg Phe Glu Ile Lys Ala Glu Pro 
    290                 295                 300                 


His Arg Tyr Gly Asn Gln Ile Lys Leu Gly Val Arg Gly Lys Ala Tyr 
305                 310                 315                 320 


Glu Trp Leu Glu Ser Ile Val Lys Thr Asn Glu Lys Arg Ile Pro Glu 
                325                 330                 335     


Ile Val Tyr Arg Leu Lys Pro Asn Glu Ile Ala Ser Phe Leu Arg Gly 
            340                 345                 350         


Leu Phe Ser Ala Asp Gly Tyr Val Asp Asn Asp Met Ala Ile Arg Leu 
        355                 360                 365             


Thr Ser Lys Ser Arg Glu Leu Leu Arg Glu Val Gln Asp Leu Leu Leu 
    370                 375                 380                 


Leu Phe Gly Ile Leu Ser Lys Ile Tyr Glu Arg Pro Tyr Lys Arg Glu 
385                 390                 395                 400 


Phe Lys Tyr Thr Thr Lys Asp Gly Glu Glu Arg Thr Tyr Thr Thr Glu 
                405                 410                 415     


Gly Tyr Tyr Glu Leu Val Ile Ala Asn Tyr Ser Arg Lys Ile Phe Ala 
            420                 425                 430         


Glu Arg Ile Gly Leu Glu Gly Tyr Lys Met Glu Lys Leu Ser Leu Glu 
        435                 440                 445             


Lys Ile Lys Val Asp Glu Pro Ile Val Thr Val Glu Ser Val Glu Ile 
    450                 455                 460                 


Leu Gly Lys Lys Leu Val Tyr Asp Phe Thr Val Pro Glu His His Met 
465                 470                 475                 480 


Tyr Ile Ser Asn Gly Phe Met Ser His Asn Ser Gly Val Lys Val Ala 
                485                 490                 495     


Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly 
            500                 505                 510         


Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly 
        515                 520                 525             


His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile 
    530                 535                 540                 


Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val 
545                 550                 555                 560 


Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu 
                565                 570                 575     


Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly 
            580                 585                 590         


Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr 
        595                 600                 605             


Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly 
    610                 615                 620                 


Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala 
625                 630                 635                 640 


Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly 
                645                 650                 655     


Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly 
            660                 665                 670         


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
        675                 680                 685             


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
    690                 695                 700                 


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
705                 710                 715                 720 


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730                 735     


<210>  230
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Pab_RtcB_Pab_Hyp-2

<400>  230

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Pro 
            100                 105                 110         


Gly Ser Lys Val Leu Thr Glu His Gly Tyr Trp Leu Lys Val Glu Glu 
        115                 120                 125             


Leu Pro Glu Lys Phe Lys Leu Gln Gly Val Lys Val Tyr Asn Leu Asp 
    130                 135                 140                 


Glu Gly His Asn Asp Thr Ser Asn Val Ala Phe Val Ala Glu Arg Glu 
145                 150                 155                 160 


Val Glu Thr Gly Glu Met Ala Val Arg Val Thr Thr Glu Ser Gly Arg 
                165                 170                 175     


Ile Ile Glu Gly Ser Glu Asp His Pro Val Leu Thr Pro Glu Gly Tyr 
            180                 185                 190         


Val Tyr Leu Gly Asn Leu Lys Glu Gly Asn Leu Val Ile Val Tyr Pro 
        195                 200                 205             


Phe Glu Gly Val Glu Tyr Glu Glu Arg Lys Gly Val Ile Leu Asp Glu 
    210                 215                 220                 


Asp Ala Phe Lys Asp Glu Asp Pro Gln Val Leu Ser Phe Leu Arg Glu 
225                 230                 235                 240 


Lys Gly Leu Val Pro Leu Arg Trp Asp Asp Pro Arg Ile Gly Thr Ile 
                245                 250                 255     


Ala Arg Ile Leu Gly Phe Ala Phe Gly Asp Gly Tyr Leu Gly Glu Met 
            260                 265                 270         


Gly Gly Arg Leu Thr Leu Thr Phe Tyr Gly Lys Glu Glu Thr Leu Arg 
        275                 280                 285             


Glu Leu Lys Lys Asp Leu Glu Arg Leu Gly Ile Ser Ala Asn Leu Tyr 
    290                 295                 300                 


Val Arg Glu Ser Ile Glu Thr Thr Ser Gly His Ser Glu Gly Lys Ser 
305                 310                 315                 320 


Leu Ser Ile Glu Leu Arg Val Thr Ser Arg Ser Phe Ala Leu Phe Leu 
                325                 330                 335     


Glu Lys Leu Gly Met Pro Arg Gly Lys Lys Thr Glu Lys Ala Tyr Arg 
            340                 345                 350         


Val Pro Gly Trp Ile Leu Glu Ala Pro Leu Trp Val Lys Arg Asn Phe 
        355                 360                 365             


Leu Ala Gly Leu Phe Ala Ala Asp Gly Ser Ile Val Glu Phe Lys Gly 
    370                 375                 380                 


Asn Thr Pro Leu Pro Ile Asn Leu Thr Gln Ser Lys Ser Asp Glu Leu 
385                 390                 395                 400 


Ala Glu Asn Leu Val Glu Phe Leu Gly Asp Val Ala Lys Leu Leu Ala 
                405                 410                 415     


Glu Phe Gly Ile Glu Thr Thr Leu Tyr Glu Val Lys Ser Lys Lys Gly 
            420                 425                 430         


Val Thr Tyr Arg Leu Ser Ile Val Gly Glu Asp Ser Ile Arg Thr Phe 
        435                 440                 445             


Val Glu Arg Ile Asn Tyr Glu Tyr Asp Pro Glu Lys Lys Val Lys Gly 
    450                 455                 460                 


Leu Ile Ala Ala Ala Tyr Leu Lys Leu Lys Glu Arg Ile Val Lys Glu 
465                 470                 475                 480 


Ala His Glu Ala Val Lys Asp Asp Phe Pro Thr Phe Glu Glu Phe Ala 
                485                 490                 495     


Lys Glu Arg Gly Tyr Glu Gly Gly Phe Val Ala Glu Lys Val Val Lys 
            500                 505                 510         


Val Glu Arg Val Lys Pro Glu Tyr Thr Lys Phe Tyr Asp Ile Gly Val 
        515                 520                 525             


Tyr His Glu Ala His Asn Phe Ile Ala Asn Gly Ile Val Val His Asn 
    530                 535                 540                 


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
545                 550                 555                 560 


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
                565                 570                 575     


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
            580                 585                 590         


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
        595                 600                 605             


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
    610                 615                 620                 


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
625                 630                 635                 640 


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
                645                 650                 655     


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
            660                 665                 670         


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
        675                 680                 685             


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
    690                 695                 700                 


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
705                 710                 715                 720 


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
                725                 730                 735     


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
            740                 745                 750         


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
        755                 760                 765             


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
    770                 775                 780                 


Ala Glu Ala Ala Thr Arg 
785                 790 


<210>  231
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pab_VMA

<400>  231

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Asp Gly 
            100                 105                 110         


Asp Thr Leu Val Leu Thr Lys Glu Phe Gly Leu Ile Lys Ile Lys Asp 
        115                 120                 125             


Leu Tyr Lys Ile Leu Asp Gly Lys Gly Lys Lys Thr Val Asn Gly Asn 
    130                 135                 140                 


Glu Glu Trp Thr Glu Leu Glu Arg Pro Ile Thr Leu Tyr Gly Tyr Lys 
145                 150                 155                 160 


Asp Gly Lys Ile Val Glu Ile Lys Ala Thr His Val Tyr Lys Gly Phe 
                165                 170                 175     


Ser Ala Gly Met Ile Glu Ile Arg Thr Arg Thr Gly Arg Lys Ile Lys 
            180                 185                 190         


Val Thr Pro Ile His Lys Leu Phe Thr Gly Arg Val Thr Lys Asn Gly 
        195                 200                 205             


Leu Glu Ile Arg Glu Val Met Ala Lys Asp Leu Lys Lys Gly Asp Arg 
    210                 215                 220                 


Ile Ile Val Ala Lys Lys Ile Asp Gly Gly Glu Arg Val Lys Leu Asn 
225                 230                 235                 240 


Ile Arg Val Glu Gln Lys Arg Gly Lys Lys Ile Arg Ile Pro Asp Val 
                245                 250                 255     


Leu Asp Glu Lys Leu Ala Glu Phe Leu Gly Tyr Leu Ile Ala Asp Gly 
            260                 265                 270         


Thr Leu Lys Pro Arg Thr Val Ala Ile Tyr Asn Asn Asp Glu Ser Leu 
        275                 280                 285             


Leu Arg Arg Ala Asn Glu Leu Ala Asn Glu Leu Phe Asn Ile Glu Gly 
    290                 295                 300                 


Lys Ile Val Lys Gly Arg Thr Val Lys Ala Leu Leu Ile His Ser Lys 
305                 310                 315                 320 


Ala Leu Val Glu Phe Phe Ser Lys Leu Gly Val Pro Arg Asn Lys Lys 
                325                 330                 335     


Ala Arg Thr Trp Lys Val Pro Lys Glu Leu Leu Ile Ser Glu Pro Glu 
            340                 345                 350         


Val Val Lys Ala Phe Ile Lys Ala Tyr Ile Met Cys Asp Gly Tyr Tyr 
        355                 360                 365             


Asp Glu Asn Lys Gly Glu Ile Glu Ile Val Thr Ala Ser Glu Glu Ala 
    370                 375                 380                 


Ala Tyr Gly Phe Ser Tyr Leu Leu Ala Lys Leu Gly Ile Tyr Ala Ile 
385                 390                 395                 400 


Ile Arg Glu Lys Ile Ile Gly Asp Lys Val Tyr Tyr Arg Val Val Ile 
                405                 410                 415     


Ser Gly Glu Ser Asn Leu Glu Lys Leu Gly Ile Glu Arg Val Gly Arg 
            420                 425                 430         


Gly Tyr Thr Ser Tyr Asp Ile Val Pro Val Glu Val Glu Glu Leu Tyr 
        435                 440                 445             


Asn Ala Leu Gly Arg Pro Tyr Ala Glu Leu Lys Arg Ala Gly Ile Glu 
    450                 455                 460                 


Ile His Asn Tyr Leu Ser Gly Glu Asn Met Ser Tyr Glu Met Phe Arg 
465                 470                 475                 480 


Lys Phe Ala Lys Phe Val Gly Met Glu Glu Ile Ala Glu Asn His Leu 
                485                 490                 495     


Thr His Val Leu Phe Asp Glu Ile Val Glu Ile Arg Tyr Ile Ser Glu 
            500                 505                 510         


Gly Gln Glu Val Tyr Asp Val Thr Thr Glu Thr His Asn Phe Ile Gly 
        515                 520                 525             


Gly Asn Met Pro Thr Leu Leu His Asn Ser Gly Val Lys Val Ala Val 
    530                 535                 540                 


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
545                 550                 555                 560 


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
                565                 570                 575     


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
            580                 585                 590         


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
        595                 600                 605             


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
    610                 615                 620                 


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
625                 630                 635                 640 


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
                645                 650                 655     


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
            660                 665                 670         


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
        675                 680                 685             


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
    690                 695                 700                 


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
705                 710                 715                 720 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
                725                 730                 735     


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
            740                 745                 750         


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
        755                 760                 765             


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780             


<210>  232
<211>  1003
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pan_CHS2

<400>  232

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ser Pro 
            100                 105                 110         


Asp Thr Met Val Arg Thr Thr Asn Gly Asp Lys Pro Ile Arg Asp Ile 
        115                 120                 125             


Ala Val Gly Asp Gln Leu Phe Asp His Glu Asp Arg Pro Val Gln Cys 
    130                 135                 140                 


Leu Ala Ala Glu Ala Ile Gln Thr Ser Arg Met Met Lys Val Thr Tyr 
145                 150                 155                 160 


Thr Gly Tyr Asn Ser Val Ser Lys Ser Ser Phe Thr Cys Thr Pro Asp 
                165                 170                 175     


His Ile Met Thr Leu Val Ala Tyr Gly Val Lys Pro Phe Arg His Ser 
            180                 185                 190         


Asn Ser Asn Arg Val Thr Trp Trp Thr Arg Cys Asp Arg Thr Glu Leu 
        195                 200                 205             


Gly Ala Asp Ala Val Glu Ile Lys Trp Asp Ala Ala Met His Asp Leu 
    210                 215                 220                 


Tyr Thr Glu Tyr Arg Glu Gln Leu Gly Arg Arg Pro Thr Asp Ala Glu 
225                 230                 235                 240 


Val Arg Lys Tyr Leu Lys Ala Ile Thr Ser Thr Arg Val Val Pro Asp 
                245                 250                 255     


Ser Glu Asp Asp Asp Ser Gln Arg Val Glu Glu Thr Tyr Gln Ser Pro 
            260                 265                 270         


Val Leu Ile Lys Leu Leu Ala Lys Leu Lys Ala Met Asp Val Asp Val 
        275                 280                 285             


Asp Gly Glu Asp Glu Ser Val Val Leu Met Leu Leu Gln Gln His Met 
    290                 295                 300                 


Glu Asp Tyr Leu Glu His Met Ile Pro Glu Pro Glu Asp Ile Ser Asp 
305                 310                 315                 320 


Glu Asp Asn Asp Asp Leu Ile Ile Asp Leu Asp Thr Asn Arg Lys Arg 
                325                 330                 335     


Lys Ile Gly Thr Ile Ser Thr Leu Ser Ser Arg Ile Ser Asp Lys Thr 
            340                 345                 350         


Phe Arg Gln Ser Pro Ser Ile Lys Ser Ser Pro Val Asn Ser Gln Gln 
        355                 360                 365             


Gln Ser Gln Asn Glu Ala Ser Gln Ser Thr Val Pro Thr Tyr Ala Ser 
    370                 375                 380                 


Val Leu Thr Glu Asp Asp His Arg Glu Met Phe Ala Pro Val Arg Ser 
385                 390                 395                 400 


Lys Leu Ala Val Arg Asp Pro Lys Cys Lys Cys Gln Asn Leu Ser Cys 
                405                 410                 415     


Lys Gly Leu Arg Arg Val Ser Thr Val Phe Glu Thr Ser Glu Gln Ala 
            420                 425                 430         


Asp Leu Ala Leu Glu Leu Leu Ser Gly Asp His Tyr Arg Val Val Asp 
        435                 440                 445             


Pro Cys Ala Val Gln Asp Met Glu Val Phe Thr Met Thr Leu Glu Glu 
    450                 455                 460                 


Tyr Gln Ala Thr Cys Thr Ala Pro Met Thr Gln His Lys Ser Lys Leu 
465                 470                 475                 480 


Arg Leu Tyr Arg Ser Pro Leu Arg Phe Gln Pro Tyr Gln Gly Ser Val 
                485                 490                 495     


Ser Pro Val Pro Ile Asp Pro Phe Trp Phe Gly Phe Trp Leu Gly Asn 
            500                 505                 510         


Gly Thr Lys Asn Asn Ser Glu Ile Thr Ser Thr Asp Pro Glu Val Glu 
        515                 520                 525             


Val Tyr Thr Gln Ala Leu Val Asp Arg Leu Asn Arg Asp Ser Ile Pro 
    530                 535                 540                 


Pro Gly Lys Ala Pro Leu Lys Val Ser Lys Tyr Lys Ile Asp Ile Gly 
545                 550                 555                 560 


Thr Lys His Val Tyr Lys Gly Glu Glu Ile Lys Thr Thr Lys Val Ala 
                565                 570                 575     


His Arg Leu Arg Val Met Ser Thr Val Ser Asn Leu Asp Lys Thr His 
            580                 585                 590         


Trp Asn Pro Val His Asp Gly Leu Arg Glu Leu Gly Leu Leu Gly Asp 
        595                 600                 605             


Lys Ser Gly Gly Ile Pro Asp Cys Tyr Met Asn Ala Asp Glu Asn Thr 
    610                 615                 620                 


Arg Leu Ala Val Leu Ala Gly Leu Ile Glu Ser Asp Gly Trp Leu Ser 
625                 630                 635                 640 


His Gly Leu Asn Cys Tyr Gly Phe Gly Gln Tyr Thr Tyr Glu Leu Lys 
                645                 650                 655     


Lys Leu Val Glu Asp Ala Arg Lys Leu Ala Leu Ser Cys Gly Ile Gln 
            660                 665                 670         


Cys Asn Pro Ile Phe Glu Arg Lys Asn Gly Lys Asp Arg Pro Glu Pro 
        675                 680                 685             


Gly Trp Phe Phe Tyr Met Gly Arg Gly Val Glu Lys Phe Gln Pro His 
    690                 695                 700                 


Leu Leu Leu Pro Arg Lys Arg Met Thr Ile Pro Phe Thr Thr Ser Lys 
705                 710                 715                 720 


Asn Arg Asp Val Arg Pro Phe Asp Val Glu Asp Ala Gly Asp Gly Glu 
                725                 730                 735     


Phe Arg Leu Ile Glu Val Ser Gly Glu Leu Phe Gln Leu Ala Asp Arg 
            740                 745                 750         


Thr Val Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
        755                 760                 765             


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
    770                 775                 780                 


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
785                 790                 795                 800 


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
                805                 810                 815     


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
            820                 825                 830         


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
        835                 840                 845             


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
    850                 855                 860                 


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
865                 870                 875                 880 


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
                885                 890                 895     


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
            900                 905                 910         


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
        915                 920                 925             


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
    930                 935                 940                 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
945                 950                 955                 960 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
                965                 970                 975     


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
            980                 985                 990         


Ser Gly Leu Val Asn Ala Glu Ala  Ala Thr Arg 
        995                 1000             


<210>  233
<211>  927
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pbr_PRP8

<400>  233

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Lys 
            100                 105                 110         


Gly Thr Leu Leu Leu Arg Tyr Asp Gly Thr Lys Val Glu Val Glu Asn 
        115                 120                 125             


Val Arg Glu Gly Asp Leu Leu Leu Gly Pro Asp Gly Gly Pro Arg Arg 
    130                 135                 140                 


Ala Phe Asn Ile Val Gly Gly Arg Asp Arg Leu Tyr Arg Ile Lys Met 
145                 150                 155                 160 


Glu Gly Gly Lys Glu Asp Leu Val Val Thr Pro Asn His Ile Leu Val 
                165                 170                 175     


Leu His Arg Glu Lys Arg Asp Gly Val Asp Lys Val Tyr Ala Arg Pro 
            180                 185                 190         


Phe Ala Leu Pro Leu Leu Gln Glu Asp Ala Thr Asp Asp Gly Glu Asp 
        195                 200                 205             


Leu Ser Glu Ile Ser Ala Ile Glu His Phe Asp Thr Met Glu Ile Thr 
    210                 215                 220                 


Ala Ala Asp Phe Ala Ser Leu Asp Pro Asn Glu Arg Lys Leu Tyr Arg 
225                 230                 235                 240 


Leu Phe Thr Ser Pro Gly Tyr Glu Leu Asn Gly Arg Pro Val Pro Ile 
                245                 250                 255     


Asp Pro Tyr Phe Leu Gly Leu Trp Leu Gly Asp Arg Ser Arg Thr Lys 
            260                 265                 270         


Ser Ser Ile Tyr Thr Asn His Glu Glu Glu Ile Arg Glu Phe Ile Ala 
        275                 280                 285             


Asp His Ala Ala Glu Leu Asp Leu Gln Leu Val Ser Tyr Val Ser Asn 
    290                 295                 300                 


Arg Pro Ser Leu Ala Ala Met Lys Asn Gly Asn Gln Leu Pro Leu Arg 
305                 310                 315                 320 


His Gln Ala Arg Gln Thr Ile Arg Lys Gln Arg Ile Ala Ala Lys Ser 
                325                 330                 335     


Ile Thr Gln Pro Gly Gly Ala Arg Ser Ser Ser Tyr Pro Ala Thr Asn 
            340                 345                 350         


Gly Gly Leu Ser Ser Asn Thr Val Thr Ser Leu His Ser Arg Glu Arg 
        355                 360                 365             


His Pro Leu Ser Glu Ser Ser Ala Ala Ala Thr Met Asn Leu Leu Pro 
    370                 375                 380                 


Arg Ser Thr Ser Val Ser Thr Ser Val Ala Ala Gln Pro Lys Ser Ser 
385                 390                 395                 400 


Met Ser Thr Phe Ile Thr Asp Ala Ile Leu Pro Ser Glu Ser Ser Asn 
                405                 410                 415     


Ile Ser Val Ile Ser Asp Ser Gly Ile Glu Ile Ser Lys Ser Ser Lys 
            420                 425                 430         


Met Leu Ser Glu Glu Glu Ala Asp Leu Asp Leu Phe Asp Ile Asp Ser 
        435                 440                 445             


Glu Asp Glu Glu Ile Glu Asp Leu Asp Glu Lys Lys Asn Val Ser Asn 
    450                 455                 460                 


Val Asp Glu Phe Pro Lys Arg Arg Arg Ile His Tyr Leu Arg Thr Gly 
465                 470                 475                 480 


Cys Arg Thr Tyr Gly Glu Leu Cys Pro Gly Glu Glu Asp Gln Ile Leu 
                485                 490                 495     


Glu Asp Ile Val Gly Arg Pro Asp Gly Thr Thr Ser Val Glu Ser Leu 
            500                 505                 510         


Leu Leu Ala Leu Glu Ala Leu Gly Leu His Thr Cys Gly Thr Asn Asp 
        515                 520                 525             


Ser Gly Ser Asp Lys Lys Arg Ile Pro Ser Val Tyr Met Lys Asn Ser 
    530                 535                 540                 


Arg Ala Val Arg Leu Ala Leu Leu Ala Gly Leu Ile Asp Ser Gly Gly 
545                 550                 555                 560 


Trp Tyr Val Asp Ser Glu Asn Thr Phe Gly Phe Ser Gln Thr Glu Asp 
                565                 570                 575     


Ser Asn Ser Thr Leu Ile Trp Asp Val Val Thr Leu Ala Arg Ser Leu 
            580                 585                 590         


Gly Phe Ser Val Ser Thr Lys Arg Arg Met Thr His Lys Pro Thr Arg 
        595                 600                 605             


Thr Gln His Lys Ala Gln Glu Phe Ala Gln Ile Ser Gly Asn Val Ala 
    610                 615                 620                 


Glu Ile Pro Ser Leu Leu Ala Arg Glu Arg Gly Val Glu Arg Pro Ile 
625                 630                 635                 640 


Ser Gln Ala His Ser Phe Lys Ile Lys Asp Ile Gln Leu Glu Thr Glu 
                645                 650                 655     


Ala Thr Glu Trp Ala Gly Phe Arg Val Asp Gln Asp Gln Leu Tyr Leu 
            660                 665                 670         


Arg His Asp Phe Leu Val Leu His Asn Ser Gly Val Lys Val Ala Val 
        675                 680                 685             


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
    690                 695                 700                 


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
705                 710                 715                 720 


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
                725                 730                 735     


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
            740                 745                 750         


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
        755                 760                 765             


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
    770                 775                 780                 


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
785                 790                 795                 800 


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
                805                 810                 815     


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
            820                 825                 830         


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
        835                 840                 845             


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
    850                 855                 860                 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
865                 870                 875                 880 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
                885                 890                 895     


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
            900                 905                 910         


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        915                 920                 925         


<210>  234
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pch_PRP8

<400>  234

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Lys 
            100                 105                 110         


Gly Thr Arg Leu Leu Arg Tyr Asp Gly Thr Glu Ile Asn Val Glu Asp 
        115                 120                 125             


Val Arg Glu Gly Asp Gln Leu Leu Gly Pro Asp Gly Glu Pro Arg Arg 
    130                 135                 140                 


Ala Phe Asn Ile Val Ser Gly Ile Asp Arg Leu Tyr Arg Val Lys Ile 
145                 150                 155                 160 


Gly Gly Glu Lys Glu Asp Leu Val Val Thr Pro Asn His Ile Leu Val 
                165                 170                 175     


Phe Tyr Arg Glu Gly Pro Ser Asp Gly Pro Glu Asn Ala Glu Arg Gln 
            180                 185                 190         


Thr Val Glu Ile Thr Ala Ala Glu Phe Ala Thr Leu Ser Thr Glu Glu 
        195                 200                 205             


Arg Ser Leu Tyr Ser Ala Phe Thr Ser Pro Ala Val Glu Lys Gly Ala 
    210                 215                 220                 


Glu Gly Ser Ala Ala Gln Met His Ser Phe Lys Val Glu Asp Ile Ser 
225                 230                 235                 240 


Leu Glu Ser Glu Lys Thr Glu Trp Ala Gly Phe Arg Val Asp Lys Asp 
                245                 250                 255     


Gln Leu Tyr Leu Arg His Asp Tyr Leu Val Leu His Asn Ser Gly Val 
            260                 265                 270         


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
        275                 280                 285             


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
    290                 295                 300                 


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
305                 310                 315                 320 


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
                325                 330                 335     


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
            340                 345                 350         


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
        355                 360                 365             


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
    370                 375                 380                 


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
385                 390                 395                 400 


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
                405                 410                 415     


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
            420                 425                 430         


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
        435                 440                 445             


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
    450                 455                 460                 


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
465                 470                 475                 480 


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
                485                 490                 495     


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
            500                 505                 510         


Ala Thr Arg 
        515 


<210>  235
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pfu_CDC21

<400>  235

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ala Pro 
            100                 105                 110         


Asp Ser Leu Val Val Val Asn Asp Lys Val Gln Glu Ile Gly Lys Leu 
        115                 120                 125             


Thr Glu Glu Trp Gly Arg Glu Val Gly Phe Leu Glu Tyr Ser Ser Gly 
    130                 135                 140                 


Ile Phe Tyr Ala Pro Tyr Leu Gly Arg Gly Ile Ser Leu Asp Leu Val 
145                 150                 155                 160 


Thr Gly Lys Val Lys Pro Ser Val Val Ser Lys Val Trp Lys Leu Lys 
                165                 170                 175     


Ser Pro Glu Glu Leu Val Thr Ile Lys Thr Ile Thr Gly Lys Glu Ile 
            180                 185                 190         


Thr Val Thr Pro Glu Thr Lys Leu Leu Thr Phe Asn Gly Thr Leu Glu 
        195                 200                 205             


Trp Lys Glu Ala Gly Lys Ile Lys Pro Gly Asp Tyr Val Leu Thr Val 
    210                 215                 220                 


Lys Lys Leu His Ile Asn Gly Lys Gln Glu Thr Leu Asp Glu Lys Leu 
225                 230                 235                 240 


Ala Tyr Lys Arg Gly Leu Ser Leu Ser Asp Pro Leu Glu Phe Phe Ser 
                245                 250                 255     


Ser Ser Glu Arg Thr Ile Ser Ala Tyr Leu Lys Gly Ile Phe Asp Lys 
            260                 265                 270         


Val Gly Arg Leu Val Gly Asp Thr Ala Val Ile Lys Val Asp Lys Asp 
        275                 280                 285             


Met Ala Lys Arg Leu Gln Ile Leu Leu Leu Arg Leu Gly Ile Val Ser 
    290                 295                 300                 


Ser Val Asp Glu Thr Gly Lys Val Ile Ile Gly Arg Glu Tyr Ile Gln 
305                 310                 315                 320 


Lys Ile Leu Gly Tyr Asn Val Ser Val Val Thr His Glu Val Glu Leu 
                325                 330                 335     


Phe Arg Glu Phe Ile Ala Glu Ile Ser Lys Phe Tyr Gly Thr Ser Glu 
            340                 345                 350         


Glu Asp Val Tyr Ser Ser Leu His Glu Lys Gly Glu Leu Asp Ile Gly 
        355                 360                 365             


Thr Val Pro Val Glu Leu Pro Glu Gly Leu Arg Glu Glu Ile Asn Arg 
    370                 375                 380                 


Glu Arg Ala Thr Tyr Ser Glu Leu Val Lys Ile Ala Gln Glu Ile Lys 
385                 390                 395                 400 


Asp Glu Lys Leu Tyr Asn Lys Leu Ala Trp Ile Leu Ser Glu Val Thr 
                405                 410                 415     


Glu Glu Glu Ala Lys Ile Lys Glu Lys Val Asn Thr Leu Lys Val Ile 
            420                 425                 430         


Leu Ser Ser Asp Leu Ile Pro Glu Arg Val Glu Ser Val Lys Ile Ile 
        435                 440                 445             


Lys Ser Pro Tyr Pro Tyr Val Tyr Asp Leu Thr Val Glu Gly Ser His 
    450                 455                 460                 


Ser Phe Ile Ala Asn Gly Phe Val Val His Asn Ser Gly Val Lys Val 
465                 470                 475                 480 


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
                485                 490                 495     


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
            500                 505                 510         


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
        515                 520                 525             


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
    530                 535                 540                 


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
545                 550                 555                 560 


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
                565                 570                 575     


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
            580                 585                 590         


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
        595                 600                 605             


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
    610                 615                 620                 


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
625                 630                 635                 640 


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
                645                 650                 655     


Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
            660                 665                 670         


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
        675                 680                 685             


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
    690                 695                 700                 


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
705                 710                 715                 720 


Arg 
    


<210>  236
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pfu_IF2

<400>  236

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Leu Pro 
            100                 105                 110         


Glu Glu Lys Val Val Leu Pro Glu Ile Gly Leu Val Thr Leu Arg Glu 
        115                 120                 125             


Leu Phe Glu Leu Ala Asn Glu Val Val Val Lys Asp Glu Glu Lys Glu 
    130                 135                 140                 


Val Arg Lys Leu Gly Lys Met Leu Thr Gly Val Asp Glu Arg Gly Asn 
145                 150                 155                 160 


Val Lys Leu Leu Asn Ala Leu Tyr Val Trp Arg Val Ala His Lys Gly 
                165                 170                 175     


Glu Met Ile Arg Val Lys Val Asn Gly Trp Tyr Ser Val Thr Val Thr 
            180                 185                 190         


Pro Glu His Pro Phe Leu Thr Asn Arg Gly Trp Val Lys Ala Gly Glu 
        195                 200                 205             


Leu Lys Glu Gly Asp Tyr Ile Ala Ile Pro Arg Arg Val Tyr Gly Asn 
    210                 215                 220                 


Glu Asp Leu Met Lys Phe Ser Lys Ile Ala Lys Glu Leu Gly Ile Lys 
225                 230                 235                 240 


Gly Asp Glu Lys Glu Phe Tyr Leu Ala Gly Ala Ser Leu Asp Ile Pro 
                245                 250                 255     


Ile Lys Val Leu Phe Leu Ala Pro Ser Lys Leu Val Ser Ala Phe Leu 
            260                 265                 270         


Arg Gly Tyr Phe Asp Ala Lys Gly Val Val Arg Glu Asn Tyr Ile Glu 
        275                 280                 285             


Val Pro Leu Phe Glu Asp Leu Pro Leu Leu Leu Leu Arg Phe Gly Ile 
    290                 295                 300                 


Val Ser Arg Ile Glu Lys Ser Thr Leu Lys Ile Ser Gly Lys Arg Asn 
305                 310                 315                 320 


Leu Glu Leu Phe Arg Lys His Val Gly Phe Thr Asp Ser Glu Lys Ala 
                325                 330                 335     


Lys Ala Leu Asp Glu Leu Ile Ser Lys Ala Lys Glu Ser Glu Arg Tyr 
            340                 345                 350         


Pro Ile Leu Glu Glu Leu Arg Arg Leu Gly Leu Leu Phe Gly Phe Thr 
        355                 360                 365             


Arg Asn Glu Leu Arg Ile Glu Glu Asn Pro Thr Tyr Glu Val Leu Met 
    370                 375                 380                 


Glu Ile Leu Glu Arg Ile Glu Arg Gly Ser Pro Asn Leu Ala Glu Lys 
385                 390                 395                 400 


Ile Ala Val Leu Glu Gly Arg Ile Lys Glu Glu Asn Tyr Leu Arg Ile 
                405                 410                 415     


Leu Glu Glu Glu Gly Leu Ile Glu Asn Gly Lys Leu Thr Glu Leu Gly 
            420                 425                 430         


Lys Glu Leu Leu Glu Val Trp Arg Asn Arg Glu Phe Asp Ser Lys Asp 
        435                 440                 445             


Val Asp Tyr Val Arg Asn Ile Val Glu Asn Leu Val Phe Leu Pro Val 
    450                 455                 460                 


Glu Lys Val Glu Arg Ile Glu Tyr Glu Gly Tyr Val Tyr Asp Val Thr 
465                 470                 475                 480 


Thr Glu Thr His Asn Phe Val Ala Asn Gly Ile Leu Val His Asn Ser 
                485                 490                 495     


Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp 
            500                 505                 510         


Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr 
        515                 520                 525             


Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala 
    530                 535                 540                 


Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu 
545                 550                 555                 560 


Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser 
                565                 570                 575     


Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala 
            580                 585                 590         


Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala 
        595                 600                 605             


Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly 
    610                 615                 620                 


Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
625                 630                 635                 640 


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
                645                 650                 655     


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
            660                 665                 670         


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
        675                 680                 685             


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
    690                 695                 700                 


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
705                 710                 715                 720 


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
                725                 730                 735     


Glu Ala Ala Thr Arg 
            740     


<210>  237
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pfu_KlbA

<400>  237

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ala Leu Tyr Asp 
            100                 105                 110         


Phe Ser Val Ile Gln Leu Ser Asn Gly Arg Phe Val Leu Ile Gly Asp 
        115                 120                 125             


Leu Val Glu Glu Leu Phe Lys Lys Tyr Ala Glu Lys Ile Lys Thr Tyr 
    130                 135                 140                 


Lys Asp Leu Glu Tyr Ile Glu Leu Asn Glu Glu Asp Arg Phe Glu Val 
145                 150                 155                 160 


Val Ser Val Ser Pro Asp Leu Lys Ala Asn Lys His Val Val Ser Arg 
                165                 170                 175     


Val Trp Arg Arg Lys Val Arg Glu Gly Glu Lys Leu Ile Arg Ile Lys 
            180                 185                 190         


Thr Arg Thr Gly Asn Glu Ile Ile Leu Thr Arg Asn His Pro Leu Phe 
        195                 200                 205             


Ala Phe Ser Asn Gly Asp Val Val Arg Lys Glu Ala Glu Lys Leu Lys 
    210                 215                 220                 


Val Gly Asp Arg Val Ala Val Met Met Arg Pro Pro Ser Pro Pro Gln 
225                 230                 235                 240 


Thr Lys Ala Val Val Asp Pro Ala Ile Tyr Val Lys Ile Ser Asp Tyr 
                245                 250                 255     


Tyr Leu Val Pro Asn Gly Lys Gly Met Ile Lys Val Pro Asn Asp Gly 
            260                 265                 270         


Ile Pro Pro Glu Lys Ala Gln Tyr Leu Leu Ser Val Asn Ser Tyr Pro 
        275                 280                 285             


Val Lys Leu Val Arg Glu Val Asp Glu Lys Leu Ser Tyr Leu Ala Gly 
    290                 295                 300                 


Val Ile Leu Gly Asp Gly Tyr Ile Ser Ser Asn Gly Tyr Tyr Ile Ser 
305                 310                 315                 320 


Ala Thr Phe Asp Asp Glu Ala Tyr Met Asp Ala Phe Val Ser Val Val 
                325                 330                 335     


Ser Asp Phe Ile Pro Asn Tyr Val Pro Ser Ile Arg Lys Asn Gly Asp 
            340                 345                 350         


Tyr Thr Ile Val Thr Val Gly Ser Lys Ile Phe Ala Glu Met Leu Ser 
        355                 360                 365             


Arg Ile Phe Gly Ile Pro Arg Gly Arg Lys Ser Met Trp Asp Ile Pro 
    370                 375                 380                 


Asp Val Val Leu Ser Asn Asp Asp Leu Met Arg Tyr Phe Ile Ala Gly 
385                 390                 395                 400 


Leu Phe Asp Ala Asp Gly Tyr Val Asp Glu Asn Gly Pro Ser Ile Val 
                405                 410                 415     


Leu Val Thr Lys Ser Glu Thr Val Ala Arg Lys Ile Trp Tyr Val Leu 
            420                 425                 430         


Gln Arg Leu Gly Ile Ile Ser Thr Val Ser Arg Val Lys Ser Arg Gly 
        435                 440                 445             


Phe Lys Glu Gly Glu Leu Phe Arg Val Ile Ile Ser Gly Val Glu Asp 
    450                 455                 460                 


Leu Ala Lys Phe Ala Lys Phe Ile Pro Leu Arg His Ser Arg Lys Arg 
465                 470                 475                 480 


Ala Lys Leu Met Glu Ile Leu Arg Thr Lys Lys Pro Tyr Arg Gly Arg 
                485                 490                 495     


Arg Thr Tyr Arg Val Pro Ile Ser Ser Asp Met Ile Ala Pro Leu Arg 
            500                 505                 510         


Gln Met Leu Gly Leu Thr Val Ala Glu Leu Ser Lys Leu Ala Ser Tyr 
        515                 520                 525             


Tyr Ala Gly Glu Lys Val Ser Glu Ser Leu Ile Arg His Ile Glu Lys 
    530                 535                 540                 


Gly Arg Val Lys Glu Ile Arg Arg Ser Thr Leu Lys Gly Ile Ala Leu 
545                 550                 555                 560 


Ala Leu Gln Gln Ile Ala Lys Asp Val Gly Asn Glu Glu Ala Trp Val 
                565                 570                 575     


Arg Ala Lys Arg Leu Gln Leu Ile Ala Glu Gly Asp Val Tyr Trp Asp 
            580                 585                 590         


Glu Val Val Ser Val Glu Glu Val Asp Pro Lys Glu Leu Gly Ile Glu 
        595                 600                 605             


Tyr Val Tyr Asp Leu Thr Val Glu Asp Asp His Asn Tyr Val Ala Asn 
    610                 615                 620                 


Gly Ile Leu Val Ser Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
625                 630                 635                 640 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
                645                 650                 655     


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
            660                 665                 670         


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
        675                 680                 685             


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
    690                 695                 700                 


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
705                 710                 715                 720 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
                725                 730                 735     


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
            740                 745                 750         


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
        755                 760                 765             


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
    770                 775                 780                 


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
785                 790                 795                 800 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
                805                 810                 815     


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
            820                 825                 830         


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
        835                 840                 845             


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
    850                 855                 860                 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
865                 870                 875     


<210>  238
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pfu_Lon

<400>  238

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ser Gly 
            100                 105                 110         


Glu Glu Val Ile Leu Ile Glu Lys Asp Gly Glu Lys Lys Val Phe Lys 
        115                 120                 125             


Leu Arg Glu Phe Val Asp Gly Leu Leu Lys Glu Ala Ser Gly Glu Gly 
    130                 135                 140                 


Met Asp Gly Ser Ile Arg Val Val Tyr Lys Asp Leu Gln Gly Glu Asn 
145                 150                 155                 160 


Ile Lys Ile Leu Thr Lys Asp Gly Leu Val Lys Leu Leu Tyr Val Asn 
                165                 170                 175     


Arg Arg Glu Gly Lys Gln Lys Leu Arg Lys Ile Val Asn Leu Glu Lys 
            180                 185                 190         


Asp Tyr Trp Leu Ala Leu Thr Pro Glu His Lys Val Tyr Thr Ile Lys 
        195                 200                 205             


Gly Leu Lys Glu Ala Gly Glu Ile Thr Lys Asp Asp Glu Ile Ile Arg 
    210                 215                 220                 


Val Pro Leu Thr Ile Leu Asp Gly Phe Asp Val Ala Glu Lys Ser Ile 
225                 230                 235                 240 


Arg Glu Glu Leu Glu Arg Leu Ser Leu Leu Pro Leu Asn Ser Glu Asp 
                245                 250                 255     


Ser Arg Leu Glu Lys Ile Ala Gly Ile Met Gly Ala Leu Phe Gly Ser 
            260                 265                 270         


Gly Gly Ile Asp Glu Asn Leu Asn Thr Leu Ser Phe Val Ser Ser Glu 
        275                 280                 285             


Lys Lys Thr Ile Glu Gln Phe Val Lys Ala Leu Ser Glu Leu Phe Gly 
    290                 295                 300                 


Glu Phe Asp Tyr Lys Ile Glu Glu Lys Glu Asn Ser Ile Ile Phe Arg 
305                 310                 315                 320 


Thr Cys Asp Lys Arg Ile Val Thr Phe Phe Ala Thr Leu Gly Ala Pro 
                325                 330                 335     


Val Gly Asp Lys Ser Lys Val Lys Leu Lys Leu Pro Trp Trp Val Lys 
            340                 345                 350         


Leu Lys Pro Ser Leu Phe Leu Ala Phe Met Asp Gly Leu Tyr Ser Ser 
        355                 360                 365             


Asn Arg Asn Asp Lys Glu Ile Leu Glu Ile Thr Gln Leu Thr Asp Asn 
    370                 375                 380                 


Val Glu Thr Phe Phe Glu Glu Ile Ser Trp Tyr Leu Ser Phe Phe Gly 
385                 390                 395                 400 


Ile Lys Ala Glu Ala Glu Glu Asp Glu Glu Lys Asp Lys Tyr Arg Ala 
                405                 410                 415     


Arg Leu Thr Leu Ser Ser Ser Ile Asp Asn Met Leu Asn Phe Ile Glu 
            420                 425                 430         


Phe Ile Pro Ile Ser Phe Ser Pro Ala Lys Arg Glu Lys Phe Phe Lys 
        435                 440                 445             


Glu Ile Glu Lys Tyr Leu Glu Tyr Ser Ile Pro Glu Lys Thr Glu Asp 
    450                 455                 460                 


Leu Lys Lys Arg Val Lys Arg Val Lys Lys Gly Glu Arg Arg Asn Phe 
465                 470                 475                 480 


Leu Glu Ser Trp Glu Glu Val Glu Val Thr Tyr Asn Val Thr Thr Glu 
                485                 490                 495     


Thr Gly Asn Leu Leu Ala Asn Gly Leu Phe Val Lys Asn Ser Gly Val 
            500                 505                 510         


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
        515                 520                 525             


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
    530                 535                 540                 


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
545                 550                 555                 560 


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
                565                 570                 575     


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
            580                 585                 590         


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
        595                 600                 605             


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
    610                 615                 620                 


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
625                 630                 635                 640 


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
                645                 650                 655     


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
            660                 665                 670         


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
        675                 680                 685             


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
    690                 695                 700                 


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
705                 710                 715                 720 


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
                725                 730                 735     


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
            740                 745                 750         


Ala Thr Arg 
        755 


<210>  239
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pfu_RFC

<400>  239

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Gly 
            100                 105                 110         


Asp Thr Lys Val Ile Ala Asn Gly Gln Leu Phe Glu Leu Gly Glu Leu 
        115                 120                 125             


Val Glu Lys Leu Ser Gly Gly Arg Phe Gly Pro Thr Pro Val Lys Gly 
    130                 135                 140                 


Leu Lys Val Leu Gly Ile Asp Glu Asp Gly Lys Leu Arg Glu Phe Glu 
145                 150                 155                 160 


Val Gln Tyr Val Tyr Lys Asp Arg Thr Asp Arg Leu Ile Lys Ile Lys 
                165                 170                 175     


Thr Gln Leu Gly Arg Glu Leu Lys Val Thr Pro Tyr His Pro Leu Leu 
            180                 185                 190         


Val Asn Arg Glu Asn Gly Glu Ile Lys Trp Ile Lys Ala Glu Glu Leu 
        195                 200                 205             


Lys Pro Gly Asp Lys Leu Ala Ile Pro Ser Phe Leu Pro Leu Ile Thr 
    210                 215                 220                 


Gly Glu Asn Pro Leu Ala Glu Trp Leu Gly Tyr Phe Met Gly Ser Gly 
225                 230                 235                 240 


Tyr Ala Tyr Pro Ser Asn Ser Val Ile Thr Phe Thr Asn Glu Asp Pro 
                245                 250                 255     


Leu Ile Arg Gln Arg Phe Met Glu Leu Thr Glu Lys Leu Phe Pro Asp 
            260                 265                 270         


Ala Lys Ile Arg Glu Arg Ile His Ala Asp Gly Thr Pro Glu Val Tyr 
        275                 280                 285             


Val Val Ser Arg Lys Ala Trp Ser Leu Val Asn Ser Ile Ser Leu Thr 
    290                 295                 300                 


Leu Ile Pro Arg Glu Gly Trp Lys Gly Ile Arg Ser Phe Leu Arg Ala 
305                 310                 315                 320 


Tyr Ser Asp Cys Asn Gly Arg Ile Glu Ser Asp Ala Ile Val Leu Ser 
                325                 330                 335     


Thr Asp Asn Asn Asp Met Ala Gln Gln Ile Ala Tyr Ala Leu Ala Ser 
            340                 345                 350         


Phe Gly Ile Ile Ala Lys Met Asp Gly Glu Asp Val Ile Ile Ser Gly 
        355                 360                 365             


Ser Asp Asn Ile Glu Arg Phe Leu Asn Glu Ile Gly Phe Ser Thr Gln 
    370                 375                 380                 


Ser Lys Leu Lys Glu Ala Gln Lys Leu Ile Arg Lys Thr Asn Val Arg 
385                 390                 395                 400 


Ser Asp Gly Leu Lys Ile Asn Tyr Glu Leu Ile Ser Tyr Val Lys Asp 
                405                 410                 415     


Arg Leu Arg Leu Asn Val Asn Asp Lys Arg Asn Leu Ser Tyr Arg Asn 
            420                 425                 430         


Ala Lys Glu Leu Ser Trp Glu Leu Met Lys Glu Ile Tyr Tyr Arg Leu 
        435                 440                 445             


Glu Glu Leu Glu Arg Leu Lys Lys Val Leu Ser Glu Pro Ile Leu Ile 
    450                 455                 460                 


Asp Trp Asn Glu Val Ala Lys Lys Ser Asp Glu Val Ile Glu Lys Ala 
465                 470                 475                 480 


Lys Ile Arg Ala Glu Lys Leu Leu Glu Tyr Ile Lys Gly Glu Arg Lys 
                485                 490                 495     


Pro Ser Phe Lys Glu Tyr Ile Glu Ile Ala Lys Val Leu Gly Ile Asn 
            500                 505                 510         


Val Glu Arg Thr Ile Glu Ala Met Lys Ile Phe Ala Lys Arg Tyr Ser 
        515                 520                 525             


Ser Tyr Ala Glu Ile Gly Arg Lys Leu Gly Thr Trp Asn Phe Asn Val 
    530                 535                 540                 


Lys Thr Ile Leu Glu Ser Asp Thr Val Asp Asn Val Glu Ile Leu Glu 
545                 550                 555                 560 


Lys Ile Arg Lys Ile Glu Leu Glu Leu Ile Glu Glu Ile Leu Ser Asp 
                565                 570                 575     


Gly Lys Leu Lys Glu Gly Ile Ala Tyr Leu Ile Phe Leu Phe Gln Asn 
            580                 585                 590         


Glu Leu Tyr Trp Asp Glu Ile Thr Glu Val Lys Glu Leu Arg Gly Asp 
        595                 600                 605             


Phe Ile Ile Tyr Asp Leu His Val Pro Gly Tyr His Asn Phe Ile Ala 
    610                 615                 620                 


Gly Asn Met Pro Thr Val Val His Asn Ser Gly Val Lys Val Ala Val 
625                 630                 635                 640 


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
                645                 650                 655     


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
            660                 665                 670         


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
        675                 680                 685             


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
    690                 695                 700                 


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
705                 710                 715                 720 


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
                725                 730                 735     


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
            740                 745                 750         


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
        755                 760                 765             


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
    770                 775                 780                 


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
785                 790                 795                 800 


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
                805                 810                 815     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            820                 825                 830         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        835                 840                 845             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    850                 855                 860                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
865                 870                 875                 


<210>  240
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pfu_TopA

<400>  240

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu His Pro 
            100                 105                 110         


Asp Thr Leu Ile Leu Thr Ser Gln Gly Val Arg Lys Ile Lys Glu Leu 
        115                 120                 125             


Ser Arg Glu Gly Glu Val Phe Ala Leu Asp Phe Asn Leu Lys Leu Ser 
    130                 135                 140                 


Lys Ala Lys Tyr Arg Leu Leu Glu Arg Asp Ala Asp Glu Gln Met Tyr 
145                 150                 155                 160 


Lys Val Thr Leu Leu Asp Gly Thr Glu Leu Tyr Leu Thr Ala Asp His 
                165                 170                 175     


Pro Val Leu Val Tyr Arg Glu Gly Asn Leu Ala Phe Val Pro Ala Asp 
            180                 185                 190         


Lys Leu Arg Glu Thr Asp His Val Val Leu Val Leu Asn Lys Ser Ala 
        195                 200                 205             


Arg Asp Asn Tyr Gly Phe Leu Asp Leu Leu Leu Glu Ile Thr Asp Ser 
    210                 215                 220                 


Gln Glu Asp Tyr Ala Ile Leu Glu Asn Gly Glu Thr Leu Ser Leu His 
225                 230                 235                 240 


Ser Leu Lys Met Leu Val Glu Arg Gly Glu Ile Lys Asp Ile Ala Val 
                245                 250                 255     


Val Gly Phe Ser His Asn Asn Phe Gly Lys Val Met Leu Arg Asp Glu 
            260                 265                 270         


Leu Trp Tyr Leu Ile Gly Tyr Leu Ala Gly Lys Gly Gly Glu Ile Lys 
        275                 280                 285             


Gly Asn Gly Val Val Ile Ser Ser Arg Thr Lys Glu Ile Val Gly Leu 
    290                 295                 300                 


Thr Lys Ser Leu Asn Ile Asp Leu Ile Glu Thr Glu Glu Gly Ile Val 
305                 310                 315                 320 


Leu Ser Asn Lys Ser Phe Val Arg Leu Leu His Leu Ile His Tyr Thr 
                325                 330                 335     


Pro Arg Val Pro Glu Val Tyr Gly Ile Ile Asn Asn Thr Glu Trp Leu 
            340                 345                 350         


Lys Ala Phe Leu Ala Gly Tyr Tyr Asp Ala Thr Leu Leu Glu Gly Leu 
        355                 360                 365             


Thr Leu Glu Ala Leu Tyr Lys Ile Lys Val Tyr Leu Gln Leu Leu Gly 
    370                 375                 380                 


Ile Arg Ala Lys Ile Glu Asp Asn Lys Leu Lys Val His Leu Glu Asp 
385                 390                 395                 400 


Leu Gln Arg Phe Arg Glu Leu Leu Gly Lys Phe Ser Arg Arg Lys Leu 
                405                 410                 415     


Tyr Val Glu Thr Ser Gln Val Pro Val Phe Thr Asp Phe Asp Glu Arg 
            420                 425                 430         


Ser Tyr Asp Phe Pro Arg Ile Leu Gly Gly Asp Ile Tyr Ile Ile Gly 
        435                 440                 445             


Ile Lys Ser Ile Glu Lys Phe His Tyr Lys Gly Lys Val Tyr Asp Leu 
    450                 455                 460                 


Val Val Glu Asn Tyr His Asn Phe Ile Ala Asn Gly Ile Ala Val His 
465                 470                 475                 480 


Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
                485                 490                 495     


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
            500                 505                 510         


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
        515                 520                 525             


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
    530                 535                 540                 


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
545                 550                 555                 560 


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
                565                 570                 575     


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
            580                 585                 590         


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
        595                 600                 605             


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
    610                 615                 620                 


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
625                 630                 635                 640 


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
                645                 650                 655     


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
            660                 665                 670         


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
        675                 680                 685             


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
    690                 695                 700                 


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
705                 710                 715                 720 


Asn Ala Glu Ala Ala Thr Arg 
                725         


<210>  241
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pho_CDC21-2

<400>  241

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ala Pro 
            100                 105                 110         


Asp Thr Leu Ile Asn Thr Asp Asn Gly Arg Val Glu Ile Gly Lys Phe 
        115                 120                 125             


Val Glu Glu Trp Met Lys Glu Val Gly Glu Ile Ser Glu Glu Gly Ile 
    130                 135                 140                 


Ser Tyr Ala Pro Cys Phe Arg Lys Val Glu Thr Phe Lys Asp Gly Lys 
145                 150                 155                 160 


Ile Val Glu Ser Pro Ile Arg Arg Val Trp Lys Leu Arg Ala Pro Lys 
                165                 170                 175     


Lys Leu Val Arg Ile Lys Thr Glu Asn Gly Arg Ser Ile Ala Leu Thr 
            180                 185                 190         


Arg Glu Thr Lys Leu Leu Thr Ile Asn Asp Gly Glu Leu Ser Trp Val 
        195                 200                 205             


Glu Ala Gly Glu Val Lys Val Gly Thr Tyr Val Gly Thr Val Lys Ser 
    210                 215                 220                 


Glu Lys Asp Val Ile Pro Gly Ala Gly Lys Thr Ile Arg Asp Val Ser 
225                 230                 235                 240 


Lys Leu Tyr Asn Met Glu Met Glu Val Lys Asp Tyr Leu Thr Arg Glu 
                245                 250                 255     


Glu Val Arg Lys Ala Ile Glu Lys Leu Glu Glu Ile Met Asn Pro Met 
            260                 265                 270         


Asn Ile Lys Ile Pro Gly Val Gln Glu Ser Tyr Glu Glu Leu Leu Arg 
        275                 280                 285             


Lys Leu Glu Thr Thr Asn Asp Glu Arg Val Arg Asn Glu Thr Leu Ile 
    290                 295                 300                 


Leu Leu Ser Asp Val Ser Asp Ala His Glu Leu Ala Lys Glu Lys Ile 
305                 310                 315                 320 


Glu Lys Ile Lys Glu Ile Val Asn Ser Glu Val His Trp Glu Lys Val 
                325                 330                 335     


Thr Glu Val Gly Glu Val Asp Gly Val Glu Tyr Val Tyr Asp Leu Thr 
            340                 345                 350         


Val Glu Gly Ser His Asn Phe Val Ala Asn Gly Phe Ile Val His Asn 
        355                 360                 365             


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
    370                 375                 380                 


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
385                 390                 395                 400 


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
                405                 410                 415     


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
            420                 425                 430         


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
        435                 440                 445             


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
    450                 455                 460                 


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
465                 470                 475                 480 


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
                485                 490                 495     


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
            500                 505                 510         


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
        515                 520                 525             


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
    530                 535                 540                 


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
545                 550                 555                 560 


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
                565                 570                 575     


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
            580                 585                 590         


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
        595                 600                 605             


Ala Glu Ala Ala Thr Arg 
    610                 


<210>  242
<211>  798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pho_IF2

<400>  242

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Leu Pro 
            100                 105                 110         


Glu Glu Arg Val Ile Leu Pro Asp Tyr Gly Pro Ile Thr Leu Glu Glu 
        115                 120                 125             


Leu Phe Asn Met Thr Lys Glu Thr Val Phe Lys Asp Glu Glu Lys Glu 
    130                 135                 140                 


Val Arg Lys Leu Gly Ile Arg Met Pro Val Ala Gly Val Asp Gly Arg 
145                 150                 155                 160 


Val Arg Leu Leu Glu Gly Pro Tyr Val Trp Lys Val Arg Tyr Lys Gly 
                165                 170                 175     


Lys Met Leu Arg Val Lys Leu Lys Asp Trp His Ser Val Ala Val Thr 
            180                 185                 190         


Pro Glu His Pro Phe Leu Thr Thr Arg Gly Trp Val Arg Ala Asp Gln 
        195                 200                 205             


Leu Lys Pro Gly Asp Tyr Val Ala Val Pro Lys Ile Leu Pro Gly Lys 
    210                 215                 220                 


Asp Asp Lys Glu Lys Phe Leu Gln Tyr Val His Glu Lys Leu Lys Gly 
225                 230                 235                 240 


Lys Val His Ile Lys Leu Pro Ser Ser Asp Glu Glu Trp Glu Thr Phe 
                245                 250                 255     


Phe Tyr Phe Ala Gly Thr Ile Phe Gly Arg Glu Asn Ser Val Asn Pro 
            260                 265                 270         


Glu Gly Leu Thr His Glu Val Lys Ala Leu Leu Glu Leu Phe Lys Val 
        275                 280                 285             


Leu Phe Glu Tyr Pro Arg Glu Val Leu Arg Val Leu Phe Met Ala Pro 
    290                 295                 300                 


Val Arg Tyr Val Ala Asn Phe Leu Arg Gly Phe Phe Asp Ile Asn Gly 
305                 310                 315                 320 


Tyr Val Asn Gly Glu Glu Leu Arg Val Glu Val Arg Gly Ala Pro His 
                325                 330                 335     


Glu Val Leu Glu Glu Leu Ser Leu Ile Leu Leu Arg Leu Gly Ile Val 
            340                 345                 350         


Ser Lys Ile Tyr Pro Thr Ser Leu Ala Ile Ser Gly Arg Arg Asn Leu 
        355                 360                 365             


Glu Leu Phe Arg Arg Tyr Ile Gly Phe Ser Glu Lys Gln Lys Ala Lys 
    370                 375                 380                 


Glu Leu Glu Gly Ile Ile Arg Arg Ser Glu Asn Ser Glu Ser Tyr Pro 
385                 390                 395                 400 


Ile Phe Glu Glu Leu Arg Arg Ile Arg Leu Leu Phe Gly Phe Thr Arg 
                405                 410                 415     


Ala Glu Leu Ser Ser Thr Ile Pro Leu Tyr Ser Lys Tyr Glu Ser Lys 
            420                 425                 430         


Glu Ala Pro Ser Tyr Glu Ile Leu Met Lys Ile Leu Asn Thr Ile Glu 
        435                 440                 445             


Lys Gly Ser Lys Asp Leu Asn Lys Lys Ile Thr Ile Leu Glu Gly Arg 
    450                 455                 460                 


Val Arg Asp His Glu Tyr Ile Glu Glu Phe Lys Arg Glu Gly Leu Ile 
465                 470                 475                 480 


Lys Asp Gly Lys Leu Thr Glu Leu Gly Lys Glu Leu Leu Glu Val Trp 
                485                 490                 495     


Arg Asn Arg Glu Phe Asp Ser Arg Asp Val Asn Tyr Leu Arg Asn Ile 
            500                 505                 510         


Ile Glu Asn Phe Val Phe Leu Pro Val Glu Lys Ile Glu Glu Phe Glu 
        515                 520                 525             


Tyr Asp Gly Tyr Val Tyr Asp Val Thr Thr Glu Thr His Asn Phe Ile 
    530                 535                 540                 


Ala Asn Gly Ile Leu Val His Asn Ser Gly Val Lys Val Ala Val Leu 
545                 550                 555                 560 


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
                565                 570                 575     


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
            580                 585                 590         


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
        595                 600                 605             


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
    610                 615                 620                 


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
625                 630                 635                 640 


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
                645                 650                 655     


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
            660                 665                 670         


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
        675                 680                 685             


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
    690                 695                 700                 


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
705                 710                 715                 720 


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
                725                 730                 735     


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
            740                 745                 750         


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
        755                 760                 765             


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
    770                 775                 780                 


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795             


<210>  243
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pho_LHR

<400>  243

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ser Gly 
            100                 105                 110         


Asp Ser Lys Val Leu Thr Glu Lys Gly Pro Val Glu Ile Arg His Leu 
        115                 120                 125             


Asn Ser Gly Met Ile Val Gly Ile Asn Gly Phe Lys Ser Arg Phe Val 
    130                 135                 140                 


Lys Phe Gln Glu Leu His Gln Val Lys Tyr Gln Glu Tyr Gly Val Lys 
145                 150                 155                 160 


Ile Arg Thr Gln Leu Gly Phe Glu Val Lys Cys Thr Arg Glu His Arg 
                165                 170                 175     


Phe Leu Thr Ile Asp Lys Asn Gly Glu Leu Arg Trp Val Glu Ala Trp 
            180                 185                 190         


Arg Leu Lys Glu Gly Asp Tyr Val Gly Ile Ile Arg Lys Leu Pro Ser 
        195                 200                 205             


Pro Asn Ser Lys Val Leu Ile Leu Asp Phe Leu Pro Glu Ser Thr Tyr 
    210                 215                 220                 


Leu Trp Leu Asn Lys Glu Phe Leu Lys Lys Leu Lys Val Ser Ile Lys 
225                 230                 235                 240 


Glu Lys Phe Gly Ser Ile Lys Asn Tyr Ala Lys Glu Arg Gly Phe Asn 
                245                 250                 255     


Ser Ser Tyr Leu Val Lys Gln Leu Asn Gly Leu Ser Pro Phe Arg Trp 
            260                 265                 270         


Gly Arg Leu Arg Val Ile Leu Asn Asp Val Ser Ile Glu Ile Ser Arg 
        275                 280                 285             


Asp Asp Ile Glu Arg Ile Thr Ser Arg Arg Gly Lys Tyr Ser Leu Pro 
    290                 295                 300                 


Pro Glu Leu Thr Pro Gly Ile Ala Arg Leu Leu Gly Phe Trp Met Ala 
305                 310                 315                 320 


Ser Gly Ser Leu Asn Arg Asn Thr Leu Ile Phe Tyr Ser Gln Asp Lys 
                325                 330                 335     


Lys Ile Leu Glu Arg Tyr Glu Asp Leu Cys Lys Arg Glu Phe Arg Val 
            340                 345                 350         


Lys Gly Arg Ile Lys Ala Gln Asp Lys Gly Thr Tyr Ile Leu Glu Ile 
        355                 360                 365             


Pro Ser Ser Leu Leu Ser Phe Val Phe Lys Asn Leu Ala Arg Pro Lys 
    370                 375                 380                 


Leu Glu Val Pro Pro Ile Ile Tyr Ile Leu Pro Glu Lys His Lys Glu 
385                 390                 395                 400 


Glu Phe Leu Ala Gly Tyr Phe Asp Gly Asn Gly Phe Ile Lys Ile Glu 
                405                 410                 415     


Asn Gly Arg Ile His Ser Leu Gly Phe Phe Ala Phe Asn Arg Lys Phe 
            420                 425                 430         


Ala Glu Gly Ile Arg Asp Ile Leu Leu Gln Leu Gly Ile Leu Ser Ser 
        435                 440                 445             


Ile Asn Glu Gln Thr Phe Glu Val Ser Ile Ile Glu Gly Glu Lys Phe 
    450                 455                 460                 


Leu Lys Ile Val Asn Ser Trp Arg Ser Asn Tyr Tyr Lys Glu Trp Glu 
465                 470                 475                 480 


Asp Val Ile Pro Asn Leu Glu Lys Arg Leu Lys Glu Ile Glu Glu Lys 
                485                 490                 495     


Leu Gly Tyr Pro Gly Thr Tyr Asn Arg Arg Glu Ile Arg Arg Ser Glu 
            500                 505                 510         


Leu Lys Ala Ile Ile Lys Leu Tyr Glu Lys Val Ala Arg Glu Arg Gly 
        515                 520                 525             


Leu Asn Asp Val Leu Lys Glu Leu Ser Tyr Leu Lys Glu Leu Ser Glu 
    530                 535                 540                 


Gly Asp Ile Phe Phe Asp Arg Ile Thr Ser Ile Glu Pro Val Tyr Leu 
545                 550                 555                 560 


Asp Val Ala Tyr Gly Ile Ile Asn Ser Glu Thr Gly Asn Tyr Val Val 
                565                 570                 575     


Asn Gly Phe Val Ser Lys Asn Ser Gly Val Lys Val Ala Val Leu Asp 
            580                 585                 590         


Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser 
        595                 600                 605             


Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr 
    610                 615                 620                 


His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu 
625                 630                 635                 640 


Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala 
                645                 650                 655     


Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala 
            660                 665                 670         


Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser 
        675                 680                 685             


Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly 
    690                 695                 700                 


Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser 
705                 710                 715                 720 


Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln 
                725                 730                 735     


Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile 
            740                 745                 750         


Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr 
        755                 760                 765             


Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
    770                 775                 780                 


Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile 
785                 790                 795                 800 


Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu 
                805                 810                 815     


Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            820                 825                 


<210>  244
<211>  828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pho_Lon

<400>  244

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ser Gly 
            100                 105                 110         


Glu Glu Val Ile Ile Val Glu Lys Gly Lys Asp Arg Lys Val Val Lys 
        115                 120                 125             


Leu Arg Glu Phe Val Glu Asp Ala Leu Lys Glu Pro Ser Gly Glu Gly 
    130                 135                 140                 


Met Asp Gly Asp Ile Lys Val Thr Tyr Lys Asp Leu Arg Gly Glu Asp 
145                 150                 155                 160 


Val Arg Ile Leu Thr Lys Asp Gly Phe Val Lys Leu Leu Tyr Val Asn 
                165                 170                 175     


Lys Arg Glu Gly Lys Gln Lys Leu Arg Lys Ile Val Asn Leu Asp Lys 
            180                 185                 190         


Asp Tyr Trp Leu Ala Val Thr Pro Asp His Lys Val Phe Thr Ser Glu 
        195                 200                 205             


Gly Leu Lys Glu Ala Gly Glu Ile Thr Glu Lys Asp Glu Ile Ile Arg 
    210                 215                 220                 


Val Pro Leu Val Ile Leu Asp Gly Pro Lys Ile Ala Ser Thr Tyr Gly 
225                 230                 235                 240 


Glu Asp Gly Lys Phe Asp Asp Tyr Ile Arg Trp Lys Lys Tyr Tyr Glu 
                245                 250                 255     


Lys Thr Gly Asn Gly Tyr Lys Arg Ala Ala Lys Glu Leu Asn Ile Lys 
            260                 265                 270         


Glu Ser Thr Leu Arg Trp Trp Thr Gln Gly Ala Lys Pro Asn Ser Leu 
        275                 280                 285             


Lys Met Ile Glu Glu Leu Glu Lys Leu Asn Leu Leu Pro Leu Thr Ser 
    290                 295                 300                 


Glu Asp Ser Arg Leu Glu Lys Val Ala Ile Ile Leu Gly Ala Leu Phe 
305                 310                 315                 320 


Ser Asp Gly Asn Ile Asp Arg Asn Phe Asn Thr Leu Ser Phe Ile Ser 
                325                 330                 335     


Ser Glu Arg Lys Ala Ile Glu Arg Phe Val Glu Thr Leu Lys Glu Leu 
            340                 345                 350         


Phe Gly Glu Phe Asn Tyr Glu Ile Arg Asp Asn His Glu Ser Leu Gly 
        355                 360                 365             


Lys Ser Ile Leu Phe Arg Thr Trp Asp Arg Arg Ile Ile Arg Phe Phe 
    370                 375                 380                 


Val Ala Leu Gly Ala Pro Val Gly Asn Lys Thr Lys Val Lys Leu Glu 
385                 390                 395                 400 


Leu Pro Trp Trp Ile Lys Leu Lys Pro Ser Leu Phe Leu Ala Phe Met 
                405                 410                 415     


Asp Gly Leu Tyr Ser Gly Asp Gly Ser Val Pro Arg Phe Ala Arg Tyr 
            420                 425                 430         


Glu Glu Gly Ile Lys Phe Asn Gly Thr Phe Glu Ile Ala Gln Leu Thr 
        435                 440                 445             


Asp Asp Val Glu Lys Lys Leu Pro Phe Phe Glu Glu Ile Ala Trp Tyr 
    450                 455                 460                 


Leu Ser Phe Phe Gly Ile Lys Ala Lys Val Arg Val Asp Lys Thr Gly 
465                 470                 475                 480 


Asp Lys Tyr Lys Val Arg Leu Ile Phe Ser Gln Ser Ile Asp Asn Val 
                485                 490                 495     


Leu Asn Phe Leu Glu Phe Ile Pro Ile Ser Leu Ser Pro Ala Lys Arg 
            500                 505                 510         


Glu Lys Phe Leu Arg Glu Val Glu Ser Tyr Leu Ala Ala Val Pro Glu 
        515                 520                 525             


Ser Ser Leu Ala Gly Arg Ile Glu Glu Leu Arg Glu His Phe Asn Arg 
    530                 535                 540                 


Ile Lys Lys Gly Glu Arg Arg Ser Phe Ile Glu Thr Trp Glu Val Val 
545                 550                 555                 560 


Asn Val Thr Tyr Asn Val Thr Thr Glu Thr Gly Asn Leu Leu Ala Asn 
                565                 570                 575     


Gly Leu Phe Val Lys Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
            580                 585                 590         


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
        595                 600                 605             


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
    610                 615                 620                 


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
625                 630                 635                 640 


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
                645                 650                 655     


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
            660                 665                 670         


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
        675                 680                 685             


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
    690                 695                 700                 


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
705                 710                 715                 720 


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
                725                 730                 735     


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
            740                 745                 750         


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
        755                 760                 765             


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
    770                 775                 780                 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
785                 790                 795                 800 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
                805                 810                 815     


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            820                 825             


<210>  245
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pho_Pol_I

<400>  245

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Ile Leu Pro 
            100                 105                 110         


Asp Glu Trp Leu Pro Ile Val Glu Asn Glu Lys Val Arg Phe Val Lys 
        115                 120                 125             


Ile Gly Asp Phe Ile Asp Arg Glu Ile Glu Glu Asn Ala Glu Arg Val 
    130                 135                 140                 


Lys Arg Asp Gly Glu Thr Glu Ile Leu Glu Val Lys Asp Leu Lys Ala 
145                 150                 155                 160 


Leu Ser Phe Asn Arg Glu Thr Lys Lys Ser Glu Leu Lys Lys Val Lys 
                165                 170                 175     


Ala Leu Ile Arg His Arg Tyr Ser Gly Lys Val Tyr Ser Ile Lys Leu 
            180                 185                 190         


Lys Ser Gly Arg Arg Ile Lys Ile Thr Ser Gly His Ser Leu Phe Ser 
        195                 200                 205             


Val Lys Asn Gly Lys Leu Val Lys Val Arg Gly Asp Glu Leu Lys Pro 
    210                 215                 220                 


Gly Asp Leu Val Val Val Pro Gly Arg Leu Lys Leu Pro Glu Ser Lys 
225                 230                 235                 240 


Gln Val Leu Asn Leu Val Glu Leu Leu Leu Lys Leu Pro Glu Glu Glu 
                245                 250                 255     


Thr Ser Asn Ile Val Met Met Ile Pro Val Lys Gly Arg Lys Asn Phe 
            260                 265                 270         


Phe Lys Gly Met Leu Lys Thr Leu Tyr Trp Ile Phe Gly Glu Gly Glu 
        275                 280                 285             


Arg Pro Arg Thr Ala Gly Arg Tyr Leu Lys His Leu Glu Arg Leu Gly 
    290                 295                 300                 


Tyr Val Lys Leu Lys Arg Arg Gly Cys Glu Val Leu Asp Trp Glu Ser 
305                 310                 315                 320 


Leu Lys Arg Tyr Arg Lys Leu Tyr Glu Thr Leu Ile Lys Asn Leu Lys 
                325                 330                 335     


Tyr Asn Gly Asn Ser Arg Ala Tyr Met Val Glu Phe Asn Ser Leu Arg 
            340                 345                 350         


Asp Val Val Ser Leu Met Pro Ile Glu Glu Leu Lys Glu Trp Ile Ile 
        355                 360                 365             


Gly Glu Pro Arg Gly Pro Lys Ile Gly Thr Phe Ile Asp Val Asp Asp 
    370                 375                 380                 


Ser Phe Ala Lys Leu Leu Gly Tyr Tyr Ile Ser Ser Gly Asp Val Glu 
385                 390                 395                 400 


Lys Asp Arg Val Lys Phe His Ser Lys Asp Gln Asn Val Leu Glu Asp 
                405                 410                 415     


Ile Ala Lys Leu Ala Glu Lys Leu Phe Gly Lys Val Arg Arg Gly Arg 
            420                 425                 430         


Gly Tyr Ile Glu Val Ser Gly Lys Ile Ser His Ala Ile Phe Arg Val 
        435                 440                 445             


Leu Ala Glu Gly Lys Arg Ile Pro Glu Phe Ile Phe Thr Ser Pro Met 
    450                 455                 460                 


Asp Ile Lys Val Ala Phe Leu Lys Gly Leu Asn Gly Asn Ala Glu Glu 
465                 470                 475                 480 


Leu Thr Phe Ser Thr Lys Ser Glu Leu Leu Val Asn Gln Leu Ile Leu 
                485                 490                 495     


Leu Leu Asn Ser Ile Gly Val Ser Asp Ile Lys Ile Glu His Glu Lys 
            500                 505                 510         


Gly Val Tyr Arg Val Tyr Ile Asn Lys Lys Glu Ser Ser Asn Gly Asp 
        515                 520                 525             


Ile Val Leu Asp Ser Val Glu Ser Ile Glu Val Glu Lys Tyr Glu Gly 
    530                 535                 540                 


Tyr Val Tyr Asp Leu Ser Val Glu Asp Asn Glu Asn Phe Leu Val Gly 
545                 550                 555                 560 


Phe Gly Leu Leu Tyr Ala His Asn Ser Gly Val Lys Val Ala Val Leu 
                565                 570                 575     


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
            580                 585                 590         


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
        595                 600                 605             


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
    610                 615                 620                 


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
625                 630                 635                 640 


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
                645                 650                 655     


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
            660                 665                 670         


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
        675                 680                 685             


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
    690                 695                 700                 


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
705                 710                 715                 720 


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
                725                 730                 735     


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
            740                 745                 750         


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
        755                 760                 765             


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
    770                 775                 780                 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
785                 790                 795                 800 


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                805                 810                 


<210>  246
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pho_RadA

<400>  246

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Arg 
            100                 105                 110         


Asp Thr Glu Val Tyr Tyr Glu Asn Asp Thr Val Pro His Met Glu Ser 
        115                 120                 125             


Ile Glu Glu Met Tyr Ser Lys Tyr Ala Ser Met Asn Gly Glu Leu Pro 
    130                 135                 140                 


Phe Asp Asn Gly Tyr Ala Val Pro Leu Asp Asn Val Phe Val Tyr Thr 
145                 150                 155                 160 


Leu Asp Ile Ala Ser Gly Glu Ile Lys Lys Thr Arg Ala Ser Tyr Ile 
                165                 170                 175     


Tyr Arg Glu Lys Val Glu Lys Leu Ile Glu Ile Lys Leu Ser Ser Gly 
            180                 185                 190         


Tyr Ser Leu Lys Val Thr Pro Ser His Pro Val Leu Leu Phe Arg Asp 
        195                 200                 205             


Gly Leu Gln Trp Val Pro Ala Ala Glu Val Lys Pro Gly Asp Val Val 
    210                 215                 220                 


Val Gly Val Arg Glu Glu Val Leu Arg Arg Arg Ile Ile Ser Lys Gly 
225                 230                 235                 240 


Glu Leu Glu Phe His Glu Val Ser Ser Val Arg Ile Ile Asp Tyr Asn 
                245                 250                 255     


Asn Trp Val Tyr Asp Leu Val Ile Pro Glu Thr His Asn Phe Ile Ala 
            260                 265                 270         


Pro Asn Gly Leu Val Leu His Asn Ser Gly Val Lys Val Ala Val Leu 
        275                 280                 285             


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
    290                 295                 300                 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
305                 310                 315                 320 


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
                325                 330                 335     


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
            340                 345                 350         


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
        355                 360                 365             


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
    370                 375                 380                 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
385                 390                 395                 400 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
                405                 410                 415     


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
            420                 425                 430         


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
        435                 440                 445             


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
    450                 455                 460                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
465                 470                 475                 480 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                485                 490                 495     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            500                 505                 510         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        515                 520                 525     


<210>  247
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pho_r-Gyr

<400>  247

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Pro 
            100                 105                 110         


Asp Thr Leu Val Ser Leu Ser Asp Gly Arg Ile Ile Glu Ile Arg Glu 
        115                 120                 125             


Ala Val Glu Asn Ser Glu Glu Ser Leu Leu Gly Ile Asn Gly Leu Lys 
    130                 135                 140                 


Pro Lys Glu Ala Lys Ala Leu Lys Phe Trp Glu Ile Asp Trp Asp Gly 
145                 150                 155                 160 


Pro Ile Lys Val Ile Lys Leu Lys Asn Gly His Glu Ile Lys Ala Thr 
                165                 170                 175     


Pro Asp His Gly Leu Leu Val Met Arg Asp Gly Lys Ile Gly Trp Val 
            180                 185                 190         


Ser Ala Lys Asn Ile Arg Glu Gly Asp Tyr Val Ala Phe Ile Tyr Asn 
        195                 200                 205             


Leu Gly His Arg Gly Gly Lys Lys Tyr Thr Leu Pro Gln Leu Leu Lys 
    210                 215                 220                 


Glu Leu Gly Ile Ser Glu Tyr Glu Asn Ser Ser Ser Gln Glu Leu Asn 
225                 230                 235                 240 


Asn Arg Glu Gln Glu Met Asp Ser Lys Gln Ile Ser Ile Glu Leu Asp 
                245                 250                 255     


Glu Arg Phe Trp Tyr Ile Phe Gly Val Ile Leu Gly Lys Gly Thr Leu 
            260                 265                 270         


Lys Gly Asp Lys Val Val Ile Phe Gln Lys Asp Val Lys Pro Val Ile 
        275                 280                 285             


Glu Glu Ala Leu Pro Phe Val Arg Ile Phe Glu Ser Ala Asp His Ile 
    290                 295                 300                 


Gly Phe Ser His Leu Ile Leu Ala Glu Val Phe Arg Arg Leu Gly Val 
305                 310                 315                 320 


Gly Glu Gly Lys Leu His Ser Leu Val Phe Gly Leu Arg Glu Glu Tyr 
                325                 330                 335     


Ile Asn Ala Met Ile Ala Gly Tyr Phe Asp Ala Ser Gly Thr Phe Leu 
            340                 345                 350         


Arg Arg Ala Val Leu Thr Ser Lys Arg Gly Asp Ile Leu Arg Met Leu 
        355                 360                 365             


Ser Val Tyr Leu Tyr Gln Ile Gly Ile Val Asn Asn Leu Arg Arg Asp 
    370                 375                 380                 


Glu His Ala Gly Val Trp Glu Leu Ile Ile Ser Asp Leu Glu Lys Phe 
385                 390                 395                 400 


Arg Glu Lys Ile Tyr Pro Tyr Leu Arg Ile Lys Lys Ser Gln Phe Asp 
                405                 410                 415     


Lys Val Tyr Ser Ile Ser Lys Asn Glu Gly Asp Phe Leu Pro Val Ala 
            420                 425                 430         


Ser Ile Phe Arg Lys Leu Lys Phe Arg Asp Gly Phe Lys Asn Arg Ile 
        435                 440                 445             


Leu Asp Glu Glu Ile Pro Arg Asp Glu Val Ala Lys Val Leu Glu Tyr 
    450                 455                 460                 


Ala Glu Asp Ser Pro Glu Lys Glu Phe Leu Asn Ser Leu Val Glu Ala 
465                 470                 475                 480 


Arg Val Thr Trp Val Arg Val Glu Lys Ile Glu Glu Arg His Tyr Thr 
                485                 490                 495     


Gly Lys Leu Tyr Asp Phe Thr Thr Thr Thr Glu Asn Phe Ile Ser Asn 
            500                 505                 510         


Gly Ile Val Ser His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
        515                 520                 525             


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
    530                 535                 540                 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
545                 550                 555                 560 


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
                565                 570                 575     


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
            580                 585                 590         


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
        595                 600                 605             


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
    610                 615                 620                 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
625                 630                 635                 640 


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
                645                 650                 655     


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
            660                 665                 670         


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
        675                 680                 685             


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
    690                 695                 700                 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
705                 710                 715                 720 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
                725                 730                 735     


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
            740                 745                 750         


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760                 


<210>  248
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Pho_RtcB_Pho_Hyp-2

<400>  248

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Pro 
            100                 105                 110         


Gly Thr Arg Val Leu Thr Glu His Gly Tyr Trp Leu Lys Ile Glu Glu 
        115                 120                 125             


Met Pro Glu Lys Phe Lys Leu Gln Arg Leu Arg Val Tyr Asn Ile Glu 
    130                 135                 140                 


Glu Gly His Asn Asp Phe Ser Lys Val Val Phe Val Ala Glu Arg Glu 
145                 150                 155                 160 


Val Gly Ser Glu Glu Lys Ala Ile Arg Ile Val Thr Glu Ser Gly Lys 
                165                 170                 175     


Val Ile Glu Gly Ser Glu Asp His Pro Val Leu Thr Pro Glu Gly Tyr 
            180                 185                 190         


Val Tyr Leu Arg Asn Val Lys Glu Gly Asp Tyr Ile Leu Val Tyr Pro 
        195                 200                 205             


Phe Glu Gly Val Pro Tyr Glu Glu Lys Lys Gly Val Ile Leu Asp Glu 
    210                 215                 220                 


Ser Ala Phe Glu Gly Glu Asp Pro Gln Val Val Lys Phe Leu Arg Glu 
225                 230                 235                 240 


Arg Asn Leu Ile Pro Leu Gln Trp Lys Asp Pro Lys Val Gly Ile Leu 
                245                 250                 255     


Ala Arg Ile Leu Gly Phe Ala Leu Ala Asn Gly Tyr Ile Ser Glu Asn 
            260                 265                 270         


Asp Asn Leu Thr Phe His Gly Lys Glu Glu Val Leu Arg Glu Val Arg 
        275                 280                 285             


Lys Asp Leu Glu Glu Leu Gly Ile Glu Ala Ile Val Ala Glu Glu Asp 
    290                 295                 300                 


Lys Leu Lys Val Thr Ser Arg Glu Phe Ala Phe Leu Leu Glu Lys Leu 
305                 310                 315                 320 


Gly Met Ala His Asp Ser Ile Pro Glu Trp Ile Ile Glu Gly Pro Leu 
                325                 330                 335     


Trp Ile Lys Arg Asn Phe Leu Ala Gly Leu Phe Gly Ala Asn Gly Ser 
            340                 345                 350         


Ile Val Glu Phe Lys Gly Asp Val Pro Leu Pro Ile Thr Leu Thr His 
        355                 360                 365             


Ser Arg Glu Leu Leu Asn Asp Val Ser Arg Ile Leu Glu Gly Phe Lys 
    370                 375                 380                 


Val Arg Ala Lys Ile Lys Met Gly Lys Asn Gly Ser Tyr Gln Leu Val 
385                 390                 395                 400 


Ile Glu Asp Glu Asp Ser Ile Arg Asn Phe Leu Gly Arg Ile Asn Tyr 
                405                 410                 415     


Glu Tyr Asp Pro Glu Lys Lys Ala Arg Gly Leu Ile Ala Tyr Ala Tyr 
            420                 425                 430         


Leu Lys Phe Lys Glu Leu Met Lys Gly Asn Leu Met Thr Phe Glu Glu 
        435                 440                 445             


Phe Ala Arg Asp Arg Gly Tyr Glu Gly Gly Phe Val Ala Glu Lys Val 
    450                 455                 460                 


Ile Glu Val Lys Ser Val Lys Pro Glu Tyr Asp Lys Phe Tyr Asp Ile 
465                 470                 475                 480 


Gly Val Tyr His Ser Ala His Asn Phe Ile Ala Asn Gly Ile Val Val 
                485                 490                 495     


His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
            500                 505                 510         


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
        515                 520                 525             


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
    530                 535                 540                 


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
545                 550                 555                 560 


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
                565                 570                 575     


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
            580                 585                 590         


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
        595                 600                 605             


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
    610                 615                 620                 


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
625                 630                 635                 640 


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
                645                 650                 655     


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
            660                 665                 670         


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
        675                 680                 685             


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
    690                 695                 700                 


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
705                 710                 715                 720 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
                725                 730                 735     


Val Asn Ala Glu Ala Ala Thr Arg 
            740                 


<210>  249
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pho_VMA

<400>  249

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Asp Gly 
            100                 105                 110         


Asp Thr Leu Val Leu Thr Lys Glu Phe Gly Leu Ile Lys Ile Lys Glu 
        115                 120                 125             


Leu Tyr Glu Lys Leu Asp Gly Lys Gly Arg Lys Ile Val Glu Gly Asn 
    130                 135                 140                 


Glu Glu Trp Thr Glu Leu Glu Lys Pro Ile Thr Val Tyr Gly Tyr Lys 
145                 150                 155                 160 


Asp Gly Lys Ile Val Glu Ile Lys Ala Thr His Val Tyr Lys Gly Val 
                165                 170                 175     


Ser Ser Gly Met Val Glu Ile Arg Thr Arg Thr Gly Arg Lys Ile Lys 
            180                 185                 190         


Val Thr Pro Ile His Arg Leu Phe Thr Gly Arg Val Thr Lys Asp Gly 
        195                 200                 205             


Leu Ile Leu Lys Glu Val Met Ala Met His Val Lys Pro Gly Asp Arg 
    210                 215                 220                 


Ile Ala Val Val Lys Lys Ile Asp Gly Gly Glu Tyr Ile Lys Leu Asp 
225                 230                 235                 240 


Ser Ser Asn Val Gly Glu Ile Lys Val Pro Glu Ile Leu Asn Glu Glu 
                245                 250                 255     


Leu Ala Glu Phe Leu Gly Tyr Leu Met Ala Asn Gly Thr Leu Lys Ser 
            260                 265                 270         


Gly Ile Ile Glu Ile Tyr Cys Asp Asp Glu Ser Leu Leu Glu Arg Val 
        275                 280                 285             


Asn Ser Leu Ser Leu Lys Leu Phe Gly Val Gly Gly Arg Ile Val Gln 
    290                 295                 300                 


Lys Val Asp Gly Lys Ala Leu Val Ile Gln Ser Lys Pro Leu Val Asp 
305                 310                 315                 320 


Val Leu Arg Arg Leu Gly Val Pro Glu Asp Lys Lys Val Glu Asn Trp 
                325                 330                 335     


Lys Val Pro Arg Glu Leu Leu Leu Ser Pro Ser Asn Val Val Arg Ala 
            340                 345                 350         


Phe Val Asn Ala Tyr Ile Lys Gly Lys Glu Glu Val Glu Ile Thr Leu 
        355                 360                 365             


Ala Ser Glu Glu Gly Ala Tyr Glu Leu Ser Tyr Leu Phe Ala Lys Leu 
    370                 375                 380                 


Gly Ile Tyr Val Thr Ile Ser Lys Ser Gly Glu Tyr Tyr Lys Val Arg 
385                 390                 395                 400 


Val Ser Arg Arg Gly Asn Leu Asp Thr Ile Pro Val Glu Val Asn Gly 
                405                 410                 415     


Met Pro Lys Val Leu Pro Tyr Glu Asp Phe Arg Lys Phe Ala Lys Ser 
            420                 425                 430         


Ile Gly Leu Glu Glu Val Ala Glu Asn His Leu Gln His Ile Ile Phe 
        435                 440                 445             


Asp Glu Val Ile Asp Val Arg Tyr Ile Pro Glu Pro Gln Glu Val Tyr 
    450                 455                 460                 


Asp Val Thr Thr Glu Thr His Asn Phe Val Gly Gly Asn Met Pro Thr 
465                 470                 475                 480 


Leu Leu His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
                485                 490                 495     


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
            500                 505                 510         


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
        515                 520                 525             


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
    530                 535                 540                 


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
545                 550                 555                 560 


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
                565                 570                 575     


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
            580                 585                 590         


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
        595                 600                 605             


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
    610                 615                 620                 


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
625                 630                 635                 640 


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
                645                 650                 655     


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
            660                 665                 670         


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
        675                 680                 685             


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
    690                 695                 700                 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
705                 710                 715                 720 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730 


<210>  250
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pna_RIR1

<400>  250

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Ala 
            100                 105                 110         


Asp Thr Arg Leu Ala Thr Gln His Gly Leu Val Pro Ile Gly Trp Leu 
        115                 120                 125             


Gln Ala Asn Gly Gly Ala Leu Asp Cys Thr Val Asp Arg Arg Ala Leu 
    130                 135                 140                 


Gly Glu Asp Arg Arg Gly Thr Val Thr Arg Ala Ala Val Pro Ala Phe 
145                 150                 155                 160 


Leu Ser Ala Gly Gln Ala Glu Val Phe Lys Val Thr Thr Ala Glu Gly 
                165                 170                 175     


Tyr Gln Ile Lys Ala Thr Ala Trp His Glu Phe Tyr Thr Ala Arg Gly 
            180                 185                 190         


Lys Leu Lys Leu Ser Glu Leu Lys Ala Gly Asp Glu Leu Trp Val Gln 
        195                 200                 205             


Ser Gly Lys Gly Gln Phe Gly Ala Gln Gly Ser Gly Ala Leu Gly Leu 
    210                 215                 220                 


Leu Ile Gly Leu Ile Thr Gly Asp Gly His Phe Thr Asn Arg Gly Lys 
225                 230                 235                 240 


Asp Glu Gln Ala Ala Val Ile Ser Leu Trp Gly Glu Glu Arg Gln Leu 
                245                 250                 255     


Ala Asp Asp Ile Ala Gly Ser Val Asn Ala Leu Ile Ala Gly Thr Ser 
            260                 265                 270         


Leu Ala Pro Arg Asp Tyr Leu Val Lys Pro Val Ala Val Ala Glu Arg 
        275                 280                 285             


Asn Met Val Phe Ile Arg Ser Thr Met Leu Val Arg Val Leu Asp Gly 
    290                 295                 300                 


Tyr Gly Phe Asn Gly Glu Thr Lys Leu Glu Val Pro Glu Val Val Trp 
305                 310                 315                 320 


Arg Gly Ser Glu Ala Cys Met Arg Gly Tyr Leu Gln Gly Leu Phe Gln 
                325                 330                 335     


Thr Asp Gly Thr Val Asn Val Ser Ser Asn Ser Gln Ser Cys Ser Val 
            340                 345                 350         


Arg Leu Ser Ser Ser His Arg Pro Leu Leu Gln Asp Val Gln Val Leu 
        355                 360                 365             


Leu Ala Asn Phe Gly Val Phe Ser Arg Ile His Glu Arg Arg Glu Ala 
    370                 375                 380                 


Gly Pro Arg Ser Leu Pro Asp Gly Gln Gly Gly Gln Arg Asp Tyr Leu 
385                 390                 395                 400 


Cys Gln Thr Gln His Glu Leu Ile Val Asp Gly Glu Ser Arg Glu Ala 
                405                 410                 415     


Phe Met Arg Glu Ile Gly Phe Leu Leu Pro Ala Lys Arg Glu Lys Tyr 
            420                 425                 430         


Asp Ala Trp Val Ala Asp Lys Ala Leu Val Lys Thr Gln Arg Phe Ala 
        435                 440                 445             


Ala Thr Ile Thr Ala Ile Glu Pro Ala Gly Val Glu Pro Val Tyr Asp 
    450                 455                 460                 


Thr Thr Gln Pro Asp Gly Asn Thr Val Ile Phe Asn Gly Leu Val Thr 
465                 470                 475                 480 


Gly Gln Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
                485                 490                 495     


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
            500                 505                 510         


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
        515                 520                 525             


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
    530                 535                 540                 


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
545                 550                 555                 560 


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
                565                 570                 575     


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
            580                 585                 590         


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
        595                 600                 605             


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
    610                 615                 620                 


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
625                 630                 635                 640 


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
                645                 650                 655     


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
            660                 665                 670         


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
        675                 680                 685             


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
    690                 695                 700                 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
705                 710                 715                 720 


Val Asn Ala Glu Ala Ala Thr Arg 
                725             


<210>  251
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pno_RPA2

<400>  251

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ser Ala 
            100                 105                 110         


Asp His Glu Val Leu Thr Ser Thr Gly Trp Lys Ala Leu Pro Ala Ile 
        115                 120                 125             


Lys Asp Ala Asp Gln Val Met Thr Leu Asp Leu Gln Thr Gly Thr Gln 
    130                 135                 140                 


Gln Trp Asn Ser Val Gln Ala Thr Thr Arg Phe Ala Arg Glu Gly Ser 
145                 150                 155                 160 


Leu Tyr Arg Leu Lys Ser Asp Asp Met Asp Ala Val Cys Asn Glu Ser 
                165                 170                 175     


His Arg Trp Tyr Leu Asn Thr Lys Asp Gln Pro Thr Thr Tyr Thr Ala 
            180                 185                 190         


Phe Thr Thr Gln Gln Met Leu Asp Asn Gln Leu Val Ala Leu Arg Asn 
        195                 200                 205             


Ser Ser Gly Lys Ala Thr Asp Gln Trp Asn His Glu Ser Gly Thr Thr 
    210                 215                 220                 


Thr His Thr Asn His Asn Ile Pro Thr Val Gly His Asn Gly Asn Val 
225                 230                 235                 240 


Met Phe Ser Trp Pro Asp Cys Pro Trp Leu Pro Arg Glu Phe Val Ala 
                245                 250                 255     


Asp Glu Ala Cys Asn Leu Asp Trp Cys Arg Phe Ile Gly Leu Val Met 
            260                 265                 270         


Gly Asp Gly Ser Ile Asp His Val Thr Asp Ala Gln Gly Gln Glu His 
        275                 280                 285             


Tyr Ser Ile Gln Ile His Gln Arg Ala Gly Asn Pro Ala Ser Asn Ala 
    290                 295                 300                 


Asn Thr Glu Asp Val Leu Glu Arg Leu Ala Ala Lys Leu Pro Asn Phe 
305                 310                 315                 320 


Val Val His Pro Ser Cys Val Ser Gly Ala Glu Glu Lys His Thr Trp 
                325                 330                 335     


Thr Ile Asn His Arg Asp Met Tyr His Phe Phe Leu Pro Met Met Arg 
            340                 345                 350         


Gly Pro Gln Ser Tyr Asp Pro Leu Asp Asn Ala Met Cys Arg Thr Tyr 
        355                 360                 365             


Gln Ala Pro Asp Tyr Gln Ala Leu Ser Arg Ser Asp Asn Glu Pro Ile 
    370                 375                 380                 


Ile Pro Val Pro Ala Asp Trp Lys Thr Gly Asn Trp Trp His Leu Arg 
385                 390                 395                 400 


Arg Trp Ile Asn Tyr Pro Trp Leu Phe Ser Leu Ala Gln Ser Gln Ala 
                405                 410                 415     


Arg Ala Met Ile Lys Gly Met Ala Ala Ala Asn Gly Asp Trp Ser Leu 
            420                 425                 430         


Ser Leu Lys Ala Arg Leu Asp Thr Gly Asp Ser Gly Val Val Arg Val 
        435                 440                 445             


Phe Ser Asn Ser Ile Pro Leu Met His Asp Met Ser Val Leu Gly Leu 
    450                 455                 460                 


Leu Ala Asp Thr Arg Val Asn Ile Gly Val Asp His Lys Lys Gly Gln 
465                 470                 475                 480 


Met Gln Leu Gln Val Pro Val Thr Met Pro Ala Leu Leu Ala Trp Cys 
                485                 490                 495     


Ile Ser Phe Ser Phe Ala Asn Ser Asp Leu Ala Val Ala Ala Pro Lys 
            500                 505                 510         


Pro Glu Ala Tyr Asp Asn Pro Arg His Asp Gly Phe Val Tyr Cys Leu 
        515                 520                 525             


Thr Val Pro Asn Gly Asn Phe Leu Ala Arg Arg Thr Val Glu Tyr Ser 
    530                 535                 540                 


Asp Asn Asp Lys Ile Gln Glu Val Ile Asp Ala Ala Gln Lys Pro Phe 
545                 550                 555                 560 


Phe Thr Gly Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
                565                 570                 575     


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
            580                 585                 590         


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
        595                 600                 605             


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
    610                 615                 620                 


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
625                 630                 635                 640 


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
                645                 650                 655     


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
            660                 665                 670         


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
        675                 680                 685             


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
    690                 695                 700                 


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
705                 710                 715                 720 


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
                725                 730                 735     


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
            740                 745                 750         


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
        755                 760                 765             


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
    770                 775                 780                 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
785                 790                 795                 800 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                805                 810 


<210>  252
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Posp-JS666_RIR1

<400>  252

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Ala 
            100                 105                 110         


Asp Thr Trp Val Met Thr Thr Ala Gly Pro Ala Gln Val Ser Glu Leu 
        115                 120                 125             


Thr Gly Arg Ser Phe Ser Ala Val Val Asp Gly Lys Ala Tyr Ala Val 
    130                 135                 140                 


Thr Ser Asp Gly Phe Phe Arg Thr Gly His Lys Pro Val Leu Ala Leu 
145                 150                 155                 160 


Arg Thr Arg Glu Gly Pro Ala Leu Arg Leu Thr Ala Asp His Arg Val 
                165                 170                 175     


Arg Arg Val Ala Arg Arg Thr Arg Tyr Thr Leu Glu Ala Glu Trp Thr 
            180                 185                 190         


Glu Ala Gly Gln Leu Gln Pro Gly Asp Glu Ile Leu Leu His Asp His 
        195                 200                 205             


Arg Ala Leu Gly Gly Trp Glu Gly Ala Gly Thr His Ala Glu Gly Tyr 
    210                 215                 220                 


Leu Leu Gly Leu Leu Ile Gly Asp Gly Thr Leu Lys Ser Asp Lys Ala 
225                 230                 235                 240 


Val Ile Ser Val Trp Ala Pro Glu Leu Lys Val Ala Gly Gly Gly Ala 
                245                 250                 255     


Val Ala Tyr Ala Gln Thr Gly Ala Gly Gly Ile Val Gln Ala Ala Glu 
            260                 265                 270         


Ala Ala Ala Ala Thr Leu Ser His Arg Val Asp Phe Arg Gly Phe Gln 
        275                 280                 285             


Arg Ser Ile Ser Gly Arg Gly Glu Ala Arg Met Ala Ser Gly Ala Val 
    290                 295                 300                 


Arg His Leu Ala His Glu Met Gly Met Arg Pro Gly His Lys Thr Ile 
305                 310                 315                 320 


Thr Thr Ala Met Glu Lys Ala Ser Ser Val Phe Thr Glu Gly Leu Leu 
                325                 330                 335     


Arg Gly Leu Phe Asp Ala Asp Gly Ser Val Gln Gly Ser Gln Glu Lys 
            340                 345                 350         


Gly Val Ser Leu Arg Leu Ser Gln Ser Asp Leu Ser Leu Leu Gln Thr 
        355                 360                 365             


Ala Gln Arg Met Leu Leu Arg Leu Gly Ile Ala Ser Thr Ile Tyr Pro 
    370                 375                 380                 


Asn Arg Arg Leu Ala Gln Ala Arg Pro Leu Pro Asp Gly Arg Gly Gly 
385                 390                 395                 400 


Leu Arg Val Tyr Glu Thr Ala Ser Gln His Glu Leu Val Ile Ser Ala 
                405                 410                 415     


Asp Asn Leu Arg Ile Tyr Ala Glu Arg Ile Gly Phe Ala Asp Thr Asp 
            420                 425                 430         


Lys Ala Asp Arg Leu Asp Gln Ala Leu Gly Ser Tyr Asn Arg Ser Leu 
        435                 440                 445             


Asn Arg Glu Arg Phe Thr Val Thr Val Glu Ser Leu Thr Glu Glu Gly 
    450                 455                 460                 


Ser Glu Asp Val Phe Asp Val Thr Val Ala Asp Ile His Ala Phe Asp 
465                 470                 475                 480 


Ala Asn Gly Leu Tyr Val His Asn Ser Gly Val Lys Val Ala Val Leu 
                485                 490                 495     


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
            500                 505                 510         


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
        515                 520                 525             


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
    530                 535                 540                 


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
545                 550                 555                 560 


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
                565                 570                 575     


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
            580                 585                 590         


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
        595                 600                 605             


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
    610                 615                 620                 


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
625                 630                 635                 640 


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
                645                 650                 655     


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
            660                 665                 670         


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
        675                 680                 685             


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
    690                 695                 700                 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
705                 710                 715                 720 


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730                 


<210>  253
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:PP-PhiEL_ORF39

<400>  253

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ala Gly Val Leu 
            100                 105                 110         


Ser Ser Lys Ile Lys Ile Pro Gly Gly Trp Lys Thr Met Gly Asn Ile 
        115                 120                 125             


Arg Val Gly Asp Glu Val Val Thr Pro Asp Gly Gly Thr Ala Lys Val 
    130                 135                 140                 


Leu Ala Val His Pro Gln Gly Val Thr Lys Val Val Arg Val His Phe 
145                 150                 155                 160 


Lys Asp Gly Arg Tyr Thr Asp Val Ser Pro Asp His Leu Trp Lys Val 
                165                 170                 175     


Arg Arg His His Trp Cys Asn Asp Lys Ala Met Ala Lys Leu Thr Arg 
            180                 185                 190         


Glu Glu Val Glu Glu Arg Val Trp Arg Val Ile Thr Thr Asn Glu Leu 
        195                 200                 205             


Lys Asp Tyr Ile Gly Leu Ser Thr Lys Val Tyr Val Gln Leu Ile Glu 
    210                 215                 220                 


Pro Glu Arg Asn Ala Asp Lys Pro Phe Lys Ile His Pro Tyr Val Leu 
225                 230                 235                 240 


Gly Val Leu Leu Gly Asp Gly Cys Ile Ser Gln Lys Ala Val Asp Ile 
                245                 250                 255     


Thr Lys Pro Tyr Gln Gln Leu Phe Asp Lys Val Gln Ser Leu Leu Pro 
            260                 265                 270         


Glu His Leu Glu Cys Val Trp Arg Pro Asn Arg Lys Gly Asp Gly Glu 
        275                 280                 285             


Pro Lys Thr Phe Gly Ile Arg Phe Lys Asp Arg Arg Ser Glu Gln His 
    290                 295                 300                 


Ile Asn Trp His Ile Arg Asp Gly Leu Lys Glu Leu Gly Leu Tyr Gly 
305                 310                 315                 320 


Met Arg Ser Trp Gly Lys Val Ile Pro Glu Glu Tyr Leu His Gly Ser 
                325                 330                 335     


Ala Lys Gln Arg Leu Glu Leu Leu Gln Gly Leu Leu Asp Thr Asp Gly 
            340                 345                 350         


Thr Val Asp Lys His Lys Ser Val Ser Phe Ser Ser Ser Ser Lys Leu 
        355                 360                 365             


Leu Ser Leu Gly Val Gln Tyr Leu Val Arg Ser Leu Gly Gly Met Ala 
    370                 375                 380                 


Arg Leu Gln Glu Arg Thr Pro His Tyr Thr His Asn Gly Glu Lys Arg 
385                 390                 395                 400 


Glu Gly Arg Thr Asp Tyr Arg Val Tyr Ile Arg Tyr Pro Arg Pro Glu 
                405                 410                 415     


Glu Leu Phe Thr Leu Asp His Lys Arg Glu Arg Ala Val Ser His Gln 
            420                 425                 430         


His Thr Glu Thr Leu Arg Leu Gln Val Thr His Ile Glu Glu Arg Pro 
        435                 440                 445             


Asp Glu Glu Thr Gln Cys Ile Thr Ile Asp His Pro Asp His Leu Tyr 
    450                 455                 460                 


Ile Thr Asp Asp Phe Ile Val Thr His Asn Ser Gly Val Lys Val Ala 
465                 470                 475                 480 


Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly 
                485                 490                 495     


Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly 
            500                 505                 510         


His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile 
        515                 520                 525             


Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val 
    530                 535                 540                 


Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu 
545                 550                 555                 560 


Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly 
                565                 570                 575     


Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr 
            580                 585                 590         


Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly 
        595                 600                 605             


Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala 
    610                 615                 620                 


Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly 
625                 630                 635                 640 


Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly 
                645                 650                 655     


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
            660                 665                 670         


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
        675                 680                 685             


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
    690                 695                 700                 


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
705                 710                 715                 720 


<210>  254
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Pst_VMA

<400>  254

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Lys 
            100                 105                 110         


Gly Thr Lys Val Leu Met Ala Asn Gly Asp Asp Lys Asn Ile Glu Asp 
        115                 120                 125             


Ile Ala Val Gly Glu Glu Val Leu Gly Lys Asp Gly Leu Pro Arg Glu 
    130                 135                 140                 


Val Val Ala Leu Pro Arg Gly Arg Glu Thr Met Tyr Glu Val Ser Glu 
145                 150                 155                 160 


Lys Thr Gln His Arg Ala Glu Thr Val Phe Gly Thr Ala Ser Tyr Thr 
                165                 170                 175     


Cys Asn Ala Thr His Lys Leu Val Leu Gln Thr Asn Gln Arg Val Asn 
            180                 185                 190         


Ile Thr Asn His Val Leu Arg Gly Glu Ser Gln Thr Ser Val Thr Tyr 
        195                 200                 205             


Phe Gln Met Lys Thr Ala Val Ala Asp Gly Arg Glu Ile Glu Leu Pro 
    210                 215                 220                 


Lys Leu Cys Thr Lys Ser Phe Gln His Ser Ser His Gly Arg Glu Asn 
225                 230                 235                 240 


Ala Trp Lys Lys Ala Glu Val Phe Ala Ser Thr Ile Ser Arg Asp Pro 
                245                 250                 255     


Ile Asp Trp Thr Ala Glu Ala Arg Asp Ile Ser Arg Leu Gly Tyr His 
            260                 265                 270         


Val Arg Arg Ala Thr Arg Gln Leu Trp Ser Pro Val Leu Val Glu Lys 
        275                 280                 285             


Glu Val Leu Ala Pro Met Ile Ala Lys Arg Gly Phe Asp Glu Ser Ile 
    290                 295                 300                 


Ala Pro Tyr Met Ala Tyr Leu Val Gly Leu Trp Val Gly Asp Gly Tyr 
305                 310                 315                 320 


Ser Asp Arg Ala Thr Phe Ser Ile Asp Ile Gln Asp Val Glu Ile His 
                325                 330                 335     


Glu Arg Ile Lys Asp Phe Ala Ser His Ala Gly Leu Thr Pro Arg Ile 
            340                 345                 350         


Ala Cys Tyr Lys Lys Ser Arg Asp Ala Thr Ile Ser Leu His Asn Ser 
        355                 360                 365             


Glu Thr Arg Gly Lys Asn Val Arg Gln Asn Leu Asn Thr Gly Asn Leu 
    370                 375                 380                 


Leu Trp Ser Leu Leu Ala Glu Ile Cys Gly Lys Lys Glu Asn Glu Met 
385                 390                 395                 400 


Leu Phe Lys Leu Val Pro Ser Phe Leu Arg Ser Glu Ser Ile Ala Val 
                405                 410                 415     


Arg Glu Tyr Phe Ile Ser Gly Leu Val Asp Ser Asp Gly His Val Lys 
            420                 425                 430         


Arg Asp Glu Ala Asp Lys Cys Tyr Ser Ala Thr Val Lys Thr Ile Tyr 
        435                 440                 445             


Pro Ala Val Arg Asp Gly Leu Val Ser Val Ala Arg Ser Leu Gly Ile 
    450                 455                 460                 


Gln Thr Ser Val Ser Val Glu Glu Ala Lys Glu Val Asn Ser Val Lys 
465                 470                 475                 480 


His Gln Glu Ser Tyr Ala Ile Tyr Met Ala Asn Ser Ser Ala Leu Asp 
                485                 490                 495     


Ser Val Leu Ser Lys Cys Ala Ala Pro Arg Lys Arg Ala Glu Glu Pro 
            500                 505                 510         


Val Cys Val Asn Arg Glu Pro His Pro Tyr Thr Phe His Met Val Glu 
        515                 520                 525             


Lys Glu Glu Asp Asp Phe Tyr Gly Ile Thr Leu Ser Glu Asp Ser Asp 
    530                 535                 540                 


His Gln Phe Leu Leu Ser Asn Leu Ala Leu Val His Asn Ser Gly Val 
545                 550                 555                 560 


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
                565                 570                 575     


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
            580                 585                 590         


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
        595                 600                 605             


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
    610                 615                 620                 


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
625                 630                 635                 640 


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
                645                 650                 655     


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
            660                 665                 670         


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
        675                 680                 685             


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
    690                 695                 700                 


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
705                 710                 715                 720 


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
                725                 730                 735     


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            740                 745                 750         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        755                 760                 765             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    770                 775                 780                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
785                 790                 795                 800 


Ala Thr Arg 
            


<210>  255
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Rma_DnaB

<400>  255

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Gly 
            100                 105                 110         


Asp Thr Leu Ile Thr Leu Ala Asp Gly Arg Arg Val Pro Ile Arg Glu 
        115                 120                 125             


Leu Val Ser Gln Gln Asn Phe Ser Val Trp Ala Leu Asn Pro Gln Thr 
    130                 135                 140                 


Tyr Arg Leu Glu Arg Ala Arg Val Ser Arg Ala Phe Cys Thr Gly Ile 
145                 150                 155                 160 


Lys Pro Val Tyr Arg Leu Thr Thr Arg Leu Gly Arg Ser Ile Arg Ala 
                165                 170                 175     


Thr Ala Asn His Arg Phe Leu Thr Pro Gln Gly Trp Lys Arg Val Asp 
            180                 185                 190         


Glu Leu Gln Pro Gly Asp Tyr Leu Ala Leu Pro Arg Arg Ile Pro Thr 
        195                 200                 205             


Ala Ser Thr Pro Thr Leu Thr Glu Ala Glu Leu Ala Leu Leu Gly His 
    210                 215                 220                 


Leu Ile Gly Asp Gly Cys Thr Leu Pro His His Val Ile Gln Tyr Thr 
225                 230                 235                 240 


Ser Arg Asp Ala Asp Leu Ala Thr Leu Val Ala His Leu Ala Thr Lys 
                245                 250                 255     


Val Phe Gly Ser Lys Val Thr Pro Gln Ile Arg Lys Glu Leu Arg Trp 
            260                 265                 270         


Tyr Gln Val Tyr Leu Arg Ala Ala Arg Pro Leu Ala Pro Gly Lys Arg 
        275                 280                 285             


Asn Pro Ile Ser Asp Trp Leu Arg Asp Leu Gly Ile Phe Gly Leu Arg 
    290                 295                 300                 


Ser Tyr Glu Lys Lys Val Pro Ala Leu Leu Phe Cys Gln Thr Ser Glu 
305                 310                 315                 320 


Ala Ile Ala Thr Phe Leu Arg His Leu Trp Ala Thr Asp Gly Cys Ile 
                325                 330                 335     


Gln Met Arg Arg Gly Lys Lys Pro Tyr Pro Ala Val Tyr Tyr Ala Thr 
            340                 345                 350         


Ser Ser Tyr Gln Leu Ala Arg Asp Val Gln Ser Leu Leu Leu Arg Leu 
        355                 360                 365             


Gly Ile Asn Ala Arg Leu Lys Thr Val Ala Gln Gly Glu Lys Gly Arg 
    370                 375                 380                 


Val Gln Tyr His Val Lys Val Ser Gly Arg Glu Asp Leu Leu Arg Phe 
385                 390                 395                 400 


Val Glu Lys Ile Gly Ala Val Gly Ala Arg Gln Arg Ala Ala Leu Ala 
                405                 410                 415     


Ser Val Tyr Asp Tyr Leu Ser Val Arg Thr Gly Asn Pro Asn Arg Asp 
            420                 425                 430         


Ile Ile Pro Val Ala Leu Trp Tyr Glu Leu Val Arg Glu Ala Met Tyr 
        435                 440                 445             


Gln Arg Gly Ile Ser His Arg Gln Leu His Ala Asn Leu Gly Met Ala 
    450                 455                 460                 


Tyr Gly Gly Met Thr Leu Phe Arg Gln Asn Leu Ser Arg Ala Arg Ala 
465                 470                 475                 480 


Leu Arg Leu Ala Glu Ala Ala Ala Cys Pro Glu Leu Arg Gln Leu Ala 
                485                 490                 495     


Gln Ser Asp Val Tyr Trp Asp Pro Ile Val Ser Ile Glu Pro Asp Gly 
            500                 505                 510         


Val Glu Glu Val Phe Asp Leu Thr Val Pro Gly Pro His Asn Phe Val 
        515                 520                 525             


Ala Asn Asp Ile Ile Ala His Asn Ser Gly Val Lys Val Ala Val Leu 
    530                 535                 540                 


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
545                 550                 555                 560 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
                565                 570                 575     


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
            580                 585                 590         


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
        595                 600                 605             


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
    610                 615                 620                 


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
625                 630                 635                 640 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
                645                 650                 655     


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
            660                 665                 670         


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
        675                 680                 685             


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
    690                 695                 700                 


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
705                 710                 715                 720 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
                725                 730                 735     


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
            740                 745                 750         


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
        755                 760                 765             


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780         


<210>  256
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Rsp_Rir1

<400>  256

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Ala 
            100                 105                 110         


Glu Thr Trp Val Met Thr Asp Glu Gly Ala Arg Gln Val Ser Ala Leu 
        115                 120                 125             


Leu Asp Arg Pro Phe Arg Ala Val Val Asn Gly Ile Ala Tyr Asp Ser 
    130                 135                 140                 


Gly Glu His Gly Phe Phe Cys Thr Gly Leu Lys Pro Val Lys Arg Leu 
145                 150                 155                 160 


Ser Thr Ala Cys Gly Arg His Leu Arg Leu Thr Ala Asp His Leu Val 
                165                 170                 175     


Arg Lys Val Val Gly Lys Thr Arg Trp Arg Gln Glu Val Glu Trp Val 
            180                 185                 190         


Pro Ala Gly Asp Leu Arg Pro Gly Asp Glu Val Lys Leu His Asp His 
        195                 200                 205             


Arg Thr Ala Met Ile Gln Thr Arg Pro Glu Asp Glu Arg Gly Tyr Leu 
    210                 215                 220                 


Leu Gly Leu Leu Ile Gly Asp Gly Val Ile Arg Asp Asp Lys Thr Leu 
225                 230                 235                 240 


Ile Ser Val Trp Pro Gln Glu Glu Cys Ile Gly Ala Gln Pro Leu Gly 
                245                 250                 255     


His Pro Val Met His Lys Val Glu Ala Leu Leu Arg Asp Leu Pro His 
            260                 265                 270         


Arg Ala Asp Phe Ala Gly Trp Gln Lys Val Glu Gly Arg Gly Glu Tyr 
        275                 280                 285             


Arg Ile Gly Thr Ala Ala Leu Thr Ala Leu Ala Ala Glu Tyr Gly Leu 
    290                 295                 300                 


Thr Arg Gly Arg Lys Thr Ile Thr Pro Glu Ile Glu Gly Ala Glu Thr 
305                 310                 315                 320 


Ala Gly Phe Gly Ala Ala Val Leu Arg Gly Leu Phe Asp Ala Asp Gly 
                325                 330                 335     


Ser Val Gln Gly Ala Gln Glu Lys Gly Val Ser Val Arg Leu Ala Gln 
            340                 345                 350         


Ser Asp Leu Ala Leu Leu Gln Ala Ala Gln Arg Met Leu Ala Arg Leu 
        355                 360                 365             


Gly Met Asn Ala Val Ile Tyr Glu Asn Arg Arg Glu Ala Gly Arg Ala 
    370                 375                 380                 


Phe Leu Pro Asp Gly Lys Gly Gly Gln Ala His Phe Glu Thr Lys Ala 
385                 390                 395                 400 


Gln His Glu Leu Val Ile Ser Gly Glu Asn Leu Ala Thr Tyr Gln Glu 
                405                 410                 415     


Arg Ile Gly Phe Thr Asp Val Ala Lys Ala Arg Arg Leu Ala Val Ala 
            420                 425                 430         


Leu Ser Gly Tyr Lys Arg Ala Leu Asn Arg Glu Arg Phe Ser Ala Val 
        435                 440                 445             


Val Ala Asp Val Val Asp Asp Gly Met Ala Glu Val Phe Asp Val Gln 
    450                 455                 460                 


Val Pro Gly Val Asn Ala Phe Asp Ala Asn Gly Phe Tyr Val His Asn 
465                 470                 475                 480 


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
                485                 490                 495     


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
            500                 505                 510         


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
        515                 520                 525             


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
    530                 535                 540                 


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
545                 550                 555                 560 


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
                565                 570                 575     


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
            580                 585                 590         


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
        595                 600                 605             


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
    610                 615                 620                 


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
625                 630                 635                 640 


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
                645                 650                 655     


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
            660                 665                 670         


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
        675                 680                 685             


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
    690                 695                 700                 


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
705                 710                 715                 720 


Ala Glu Ala Ala Thr Arg 
                725     


<210>  257
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:SaP-SETP3_Helicase

<400>  257

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Lys Arg 
            100                 105                 110         


Gly Thr Glu Val Ile Met Phe Asp Gly Thr Thr Lys Lys Val Glu Asp 
        115                 120                 125             


Val Ile Val Gly Asp Val Leu Met Gly Pro Asp Ser Thr Pro Arg Asn 
    130                 135                 140                 


Val Leu Ser Leu Gly Arg Gly Arg Glu Met Met Tyr Glu Val Lys Pro 
145                 150                 155                 160 


Arg Lys Gly Glu Ser Tyr Thr Val Asn Glu Ser His Ile Leu Ser Leu 
                165                 170                 175     


Arg Thr Thr Thr Gly Ile Ala Lys Gly Ser Trp Pro Asp Asn Thr Val 
            180                 185                 190         


Phe Asp Ile Ser Val Arg Asp Trp Leu Lys Leu Pro Lys Tyr Val Thr 
        195                 200                 205             


Gly Pro Asn Gly Tyr Leu Lys Gly Trp Arg Val Pro Val Asp Phe Pro 
    210                 215                 220                 


Arg Lys Glu Gln Asp Glu Ala Leu Leu Pro Pro Tyr Leu Met Gly Leu 
225                 230                 235                 240 


Trp Leu Gly Asp Gly Thr Ser Ser Ser Gly Ala Ile Thr Ser Gly Glu 
                245                 250                 255     


Asn Glu Lys Glu Ile Arg Ala Tyr Leu Glu Ser Tyr Ala Ala Arg Asn 
            260                 265                 270         


Gly Met Gln Ile Arg Lys Glu Gly Leu Thr Trp Ser Ile Ser His Gly 
        275                 280                 285             


Asn Thr Gly His Lys Lys His Gly Phe Thr His Ala Leu Lys Ser Ala 
    290                 295                 300                 


Gly Val Leu Asn Asn Lys His Ile Pro His Asn Tyr Lys Cys Gly Asp 
305                 310                 315                 320 


Arg Arg Gln Arg Leu Glu Leu Leu Ala Gly Leu Leu Asp Ser Asp Gly 
                325                 330                 335     


Tyr Cys Asp Leu Ser Lys Ala Gly Phe Asp Trp Ile Ser Val Ser Glu 
            340                 345                 350         


Arg Leu Ala Asp Asp Phe Cys Tyr Leu Cys Arg Ser Leu Gly Phe Ala 
        355                 360                 365             


Ala Tyr Lys Lys Lys Thr Cys Lys Arg Cys Ala Asn Thr Asp Val Trp 
    370                 375                 380                 


Gly Asp Tyr Phe Arg Val Ser Val Ser Gly Asp Phe Ser Glu Val Pro 
385                 390                 395                 400 


Phe Val Arg Gly Arg His Gln Asn Leu Pro Lys Arg Asn Ile Asn Lys 
                405                 410                 415     


Asn Val Leu Asn Val Gly Ile Glu Ser Ile Thr Pro Val Gly Val Asp 
            420                 425                 430         


Asp Tyr Phe Gly Phe Thr Ile Asp Gly Asp Ser Arg Phe Leu Leu Gly 
        435                 440                 445             


Asp Phe Thr Val Thr His Asn Thr Ser Gly Val Lys Val Ala Val Leu 
    450                 455                 460                 


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
465                 470                 475                 480 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
                485                 490                 495     


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
            500                 505                 510         


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
        515                 520                 525             


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
    530                 535                 540                 


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
545                 550                 555                 560 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
                565                 570                 575     


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
            580                 585                 590         


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
        595                 600                 605             


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
    610                 615                 620                 


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
625                 630                 635                 640 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
                645                 650                 655     


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
            660                 665                 670         


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
        675                 680                 685             


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695                 700         


<210>  258
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Sav_Helicase

<400>  258

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ala Gln Pro Leu 
            100                 105                 110         


Asp Ser Leu Val Leu Ala Pro Thr Gly Phe Arg Arg Met Gly Asp Leu 
        115                 120                 125             


Arg Glu Gly Asp Glu Val Val Val Pro Asn Gly Glu Ile Ala Leu Ile 
    130                 135                 140                 


Asp Gly Val Phe Pro Gln Gly Val Arg Asp Val Trp Arg Ile Val Leu 
145                 150                 155                 160 


Ser Asp Gly Ser Ser Val Glu Cys Asp Asp Glu His Leu Trp Ile Val 
                165                 170                 175     


Gly Thr Ser Cys Gly Trp His Arg Gly Gln Thr Pro Lys Val Met Thr 
            180                 185                 190         


Thr Arg Glu Ile Arg Leu Asp Thr Phe Lys Ala Asn Gly Ser Ser Lys 
        195                 200                 205             


Trp Tyr Val Pro Ala Ala Thr Pro Val Asp Leu Gly Pro Asp Val Gly 
    210                 215                 220                 


Leu Pro Leu Asp Pro Tyr Leu Phe Gly Leu Leu Leu Gly Asp Gly Ser 
225                 230                 235                 240 


Phe Arg His Asn Leu Arg Leu Ser Thr Val Asp Asp Glu Ile Arg Asp 
                245                 250                 255     


Ala Ala Ala Asp Ala Val Ala Pro Asp Cys Arg Leu Val Pro Val Thr 
            260                 265                 270         


Gly Ser Arg Cys Asp Tyr Thr Ile Gln Leu Lys Gln Arg Ser Gly Gly 
        275                 280                 285             


Val Arg Asn Pro Val Ile Gln Ala Leu Arg Arg Leu Asp Leu Trp Gly 
    290                 295                 300                 


Lys Thr Ser His Gly Lys Phe Ile Pro Glu Asp Phe Lys Asn Thr Ser 
305                 310                 315                 320 


Ile Lys Asn Arg Leu Ser Leu Leu Gln Gly Leu Leu Asp Thr Asp Gly 
                325                 330                 335     


Thr Val His Ala Asp Gly Met Ser Val Ser Leu Arg Ser Ala Ser Leu 
            340                 345                 350         


Arg Leu Ala Glu Asp Val Ala Trp Leu Val Arg Ser Leu Gly Gly Arg 
        355                 360                 365             


Ala Arg Val Leu Pro Glu Lys Ala Ala Phe His Val Ser Val Ala Leu 
    370                 375                 380                 


Pro Asp Glu Tyr Ala Pro Phe Arg Leu Ser Arg Lys Ala Asp Arg Val 
385                 390                 395                 400 


Arg Pro Arg Pro Lys Tyr Asn Thr Phe Arg Arg Gly Ile Arg Ala Val 
                405                 410                 415     


Glu Tyr Val Gly Arg Lys Pro Ala Gln Cys Ile Ser Val Gly His Pro 
            420                 425                 430         


Ser His Ala Tyr Val Thr Asp Asn Phe Thr Val Thr His Asn Ser Gly 
        435                 440                 445             


Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu 
    450                 455                 460                 


Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln 
465                 470                 475                 480 


Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu 
                485                 490                 495     


Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr 
            500                 505                 510         


Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile 
        515                 520                 525             


Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn 
    530                 535                 540                 


Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val 
545                 550                 555                 560 


Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn 
                565                 570                 575     


Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met 
            580                 585                 590         


Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln 
        595                 600                 605             


Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser 
    610                 615                 620                 


Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
625                 630                 635                 640 


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
                645                 650                 655     


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
            660                 665                 670         


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
        675                 680                 685             


Ala Ala Thr Arg 
    690         


<210>  259
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Sex-IFO1128_VMA

<400>  259

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Lys 
            100                 105                 110         


Gly Thr Gln Val Met Met Ala Asp Gly Ser Asp Lys Ser Ile Glu Asp 
        115                 120                 125             


Ile Gln Leu Gly Glu Asn Val Met Gly Lys Asp Gly Thr Pro Arg Thr 
    130                 135                 140                 


Val Ile Ser Leu Pro Arg Gly Lys Glu Thr Met Tyr Glu Val Cys His 
145                 150                 155                 160 


Ser Ser Thr Lys Gly Thr Thr Lys Asp Thr Leu Met Asn Tyr Val Cys 
                165                 170                 175     


Ser Gly Asn His Lys Ile Val Met Gln Thr Pro Gln Gln Ile Gly Ile 
            180                 185                 190         


Thr Glu His Gly Ile Asp Gly Lys Thr Tyr Thr Ser Val Ser Tyr Phe 
        195                 200                 205             


Ala Leu Arg Asp Ser Gln His Gly Tyr Pro Ile Val Lys Lys Leu Thr 
    210                 215                 220                 


Lys Ser Phe Glu His Gln Gln His Gly Gly Lys Glu Gln Thr Leu Ile 
225                 230                 235                 240 


Thr Val Asn Asn Phe Val Ser Ser Leu Lys Ser Glu Pro Ile Asn Trp 
                245                 250                 255     


Asp Val Glu Ala Lys His Tyr Glu Ser Leu Gly His Tyr Val Lys Lys 
            260                 265                 270         


Cys Ser Tyr Gln Leu Ile Asn Pro Val Phe His Gln Ser Gly Lys Leu 
        275                 280                 285             


Ala Gln Glu Ile Ala Ser Leu Asn Tyr Ser Lys Asp Lys Ala Pro Leu 
    290                 295                 300                 


Leu Ala Trp Leu Ile Gly Phe Trp Val Gly Asn Gly Ala Met Arg His 
305                 310                 315                 320 


Ser Gln Phe Val Val Glu Ser Gln Asp Ile Glu Leu Val Asn Arg Ile 
                325                 330                 335     


Gln Asp Ile Ala Gly Leu Leu Asn Leu Ser Ala Thr Thr Ala Cys Tyr 
            340                 345                 350         


Tyr Ser Gly Ser Lys Asp Asp Glu Ala Lys Leu Ala Lys Leu Asn Ser 
        355                 360                 365             


Ser Ser Ala Glu Gly Phe Glu Asp Asp Leu Glu Gly Asn Pro Ser Val 
    370                 375                 380                 


Lys Glu Leu Ala Asp Met Asp Arg Leu Ser Glu Ser Lys Thr Ala Thr 
385                 390                 395                 400 


Leu Pro Thr Ala Phe Gly Val Glu Asn Ile Asp Glu Leu Ile Ile Ser 
                405                 410                 415     


Leu Gly Glu Gly Arg Gly Asn Gly Asn Val Phe Ala Gln Val Ile Gly 
            420                 425                 430         


Ser Phe Gly Ile Asp Leu Ala Asp Lys Asp Thr Leu Val Thr Lys Ile 
        435                 440                 445             


Ala His Glu Leu Ala Gly Asp Ala Phe Glu Val Arg Glu Gln Phe Val 
    450                 455                 460                 


Ala Gly Leu Val Asp Ala Ala Gly Tyr Val Arg Lys Asp Val Tyr Asp 
465                 470                 475                 480 


His Ala Ser Glu Ala Thr Ile Ser Thr Glu Ser Lys Ser Thr Val Leu 
                485                 490                 495     


Gly Leu Val Lys Ile Ala Arg Ser Leu Gly Ile Lys Ile Thr Val Thr 
            500                 505                 510         


Ser Asp Asp Ser Asp Asp Ser Asp Glu His Asp His Ala His Cys Gly 
        515                 520                 525             


His Asp His Gly Ser Ser Ser Ser Tyr Thr Ala Val Met Thr Gly Asp 
    530                 535                 540                 


Ala Leu Thr Asn Ser Met Arg Phe Cys Ala Ile Gly Arg Asn Arg Val 
545                 550                 555                 560 


Ala Ala Lys Glu Phe Met Arg Gln Ala Val Pro Phe Tyr Phe Ser Leu 
                565                 570                 575     


Glu Lys Lys Ser Glu Asp Asp Tyr Tyr Gly Ile Thr Val Pro Asp Asn 
            580                 585                 590         


Thr Asp Lys Gln Tyr Leu Leu Ser Ser Met Ala Leu Val His Asn Ser 
        595                 600                 605             


Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp 
    610                 615                 620                 


Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr 
625                 630                 635                 640 


Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala 
                645                 650                 655     


Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu 
            660                 665                 670         


Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser 
        675                 680                 685             


Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala 
    690                 695                 700                 


Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala 
705                 710                 715                 720 


Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly 
                725                 730                 735     


Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
            740                 745                 750         


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
        755                 760                 765             


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
    770                 775                 780                 


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
785                 790                 795                 800 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                805                 810                 815     


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            820                 825                 830         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        835                 840                 845             


Glu Ala Ala Thr Arg 
    850             


<210>  260
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Smar_1471

<400>  260

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Val Ser Tyr 
            100                 105                 110         


Asp Thr Pro Val Leu Ile Arg Asp Pro Ile Asn Lys Ile His Leu Val 
        115                 120                 125             


Lys Ile Gly Glu Phe Ile Asp Lys Phe Tyr Glu Glu Gly Glu Glu Arg 
    130                 135                 140                 


Thr Ala Lys His Val Asn Gly Tyr Tyr Val Leu Ser His Asp Gly Phe 
145                 150                 155                 160 


Gln Val Val Trp Lys Pro Ile Lys Tyr Val Leu Arg His Arg Thr Asn 
                165                 170                 175     


Glu Ile Tyr Glu Ile Ile Tyr Glu Gly Gly Gly Lys Leu Glu Ala Thr 
            180                 185                 190         


Gly Ser His Ser Val Phe Val Leu Asp Pro Asp Thr Leu Asp Ile Val 
        195                 200                 205             


Glu Lys Pro Val Met Leu Leu Asn Lys Gly Glu Tyr Leu Val Ser Phe 
    210                 215                 220                 


Asn Gly Val Lys Glu Asn Lys Asp His Gln Thr Ile Asp Leu Ile Asp 
225                 230                 235                 240 


Leu Val Ser Asp Tyr Asn Asp Val Tyr Val Asp Asn Ile Pro Ser Glu 
                245                 250                 255     


Leu Lys Lys His Thr Gly Gly Arg Asn Pro Ile Pro Leu Lys Gln Tyr 
            260                 265                 270         


Met Ile Leu Arg Lys Arg Val Ile Thr Lys Lys Asn Asn Ser Leu Ile 
        275                 280                 285             


Lys Leu Arg Arg Ser Lys Tyr Thr Leu Pro Ile Arg Leu Val Leu Asp 
    290                 295                 300                 


Glu Lys Leu Ala Phe Leu Phe Gly Ala Tyr Ile Ala Asn Gly Cys Val 
305                 310                 315                 320 


Lys Glu Arg Arg Asp Lys Leu Ile Cys Phe Thr Phe Gly Lys Ser Ala 
                325                 330                 335     


Lys Asn Ile Ala Asp Lys Val Met Asn Ile Met Tyr Glu Lys Phe Asn 
            340                 345                 350         


Ile Lys Pro Phe Ile Asp Asp Arg Gly Thr Tyr Ile Ile Tyr Glu Tyr 
        355                 360                 365             


Pro His Thr Leu Leu Ala Ile Ile Phe Glu Lys Leu Leu Gly Arg Lys 
    370                 375                 380                 


Leu Glu Glu Lys Lys Met Pro Glu Ile Leu Trp Ser Ser Pro Lys Ser 
385                 390                 395                 400 


Val Ile Arg Ala Phe Phe Glu Gly Leu Arg Ala Tyr Ser Gln Arg Thr 
                405                 410                 415     


Leu Arg Arg Arg Tyr Thr Ser Tyr Thr Thr Ala Asn Lys Asn Leu Ala 
            420                 425                 430         


Tyr Gln Leu Leu Trp Leu Ala Arg Phe Ala Gly Phe Tyr Ser Val Leu 
        435                 440                 445             


Lys Glu Glu Lys Glu Ala Gly Lys Asn Asn Gly Lys Thr Tyr Tyr His 
    450                 455                 460                 


Val Ile Val Tyr Leu Asp Gln Ser Tyr Arg Lys Pro Asn Ala Ser Glu 
465                 470                 475                 480 


Arg Val Pro Val Lys Pro Ile Leu Lys Leu Ile Lys Tyr Thr Lys Pro 
                485                 490                 495     


Arg Thr Met Pro Pro Glu Leu Ala Tyr Ile Lys Arg Arg Glu Phe Ile 
            500                 505                 510         


Ser Arg Lys Thr Ala Leu Lys Ala Leu Glu Trp Ile Arg Arg Asp Gly 
        515                 520                 525             


Ser Phe Thr Asp Phe Ser Arg Glu Tyr Leu Arg Lys Ile Glu Ser Leu 
    530                 535                 540                 


Ile Asn Gly Asp Ile Ile Val Leu Lys Ile Lys Asp Val Arg Lys Lys 
545                 550                 555                 560 


Gln Tyr Lys Gly Tyr Val Tyr Asp Ile Ser Val Pro Ile Thr Glu Ala 
                565                 570                 575     


Phe Phe Gly Gly Asn Ile Pro Ile Leu Leu His Asn Ser Gly Val Lys 
            580                 585                 590         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        595                 600                 605             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    610                 615                 620                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
625                 630                 635                 640 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                645                 650                 655     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            660                 665                 670         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        675                 680                 685             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    690                 695                 700                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
705                 710                 715                 720 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                725                 730                 735     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            740                 745                 750         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        755                 760                 765             


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
    770                 775                 780                 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
785                 790                 795                 800 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                805                 810                 815     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            820                 825                 830         


Thr Arg 
        


<210>  261
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Smar_MCM2

<400>  261

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Tyr His Lys 
            100                 105                 110         


Asp Phe Lys Ile Met Leu Ala Asp Gly Arg Lys Val Arg Ile Gly Asp 
        115                 120                 125             


Leu Val Asp Glu Leu Ile Gly Lys Asn Arg Glu Lys Val Ile Lys Gly 
    130                 135                 140                 


Lys Asp Thr Glu Ile Leu Phe Val Asp Asp Leu Phe Leu Leu Ser Tyr 
145                 150                 155                 160 


Asn Met Arg Ser Gly Glu Gln Val Leu Val Lys Ala Asp Arg Val Ser 
                165                 170                 175     


Arg His Lys Ala Pro Asp Gln Phe Ile Lys Leu Arg Phe Ser Asn Gly 
            180                 185                 190         


Ala Glu Ile Ile Val Thr Pro Glu His Pro Val Leu Ile Ile Asn Asn 
        195                 200                 205             


Gly Lys Ile Lys Thr Val Arg Ala Asp Thr Val Arg Lys Gly Thr Leu 
    210                 215                 220                 


Thr Ile Gly Val Leu Gly His Lys Ile Ile Lys Glu Val Asn Glu Asp 
225                 230                 235                 240 


Asp Ile Ile Asn Asn Ile Arg Arg Lys Ile Val Leu Asp Lys Glu Leu 
                245                 250                 255     


Pro Tyr Ile His Ala Lys Asn Ile Ser Glu Ala Val Glu Met Arg Asp 
            260                 265                 270         


Gln Leu Met Ser Ile Asp Ile Pro Thr Phe Ile Val Lys His Lys Asn 
        275                 280                 285             


Glu Ile Arg Leu Tyr Pro Ser Gly Pro Cys Ser Leu Arg Arg Leu Leu 
    290                 295                 300                 


Leu Met His Gly Val Glu Glu Val Val Phe Ser Asp Glu Leu Leu Tyr 
305                 310                 315                 320 


Glu Ile Met Asn Cys His Leu Tyr Pro Ala Thr Trp Tyr Glu Leu Leu 
                325                 330                 335     


Tyr Ser Met Gly Leu Thr Lys Ile Ala Lys Glu Leu Asn Val Tyr Asp 
            340                 345                 350         


Phe Glu Ile Leu Ala Gly Ile Ile Lys Lys Val Glu Lys Glu Val Ile 
        355                 360                 365             


Met Leu Ser Gln Val Leu Gly Leu Arg Asn Glu Thr Gln Thr Glu Leu 
    370                 375                 380                 


Leu His Leu Lys Ser Arg Arg Glu Leu Leu Ile Arg Leu Lys Asp Lys 
385                 390                 395                 400 


Leu Asp Met Leu Arg Lys Arg Leu Lys Asp Leu Glu Glu Ala Leu Gly 
                405                 410                 415     


Lys Asp Ala Val Ile Arg Met Ile Thr Asp Val Glu Val Ile Lys Asn 
            420                 425                 430         


Thr Asp Ser Asp Trp Val Tyr Asp Ile Thr Ile Glu Pro Tyr His Leu 
        435                 440                 445             


Phe Val Ser Asp Gly Leu Ile Leu His Asn Ser Gly Val Lys Val Ala 
    450                 455                 460                 


Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly 
465                 470                 475                 480 


Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly 
                485                 490                 495     


His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile 
            500                 505                 510         


Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val 
        515                 520                 525             


Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu 
    530                 535                 540                 


Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly 
545                 550                 555                 560 


Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr 
                565                 570                 575     


Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly 
            580                 585                 590         


Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala 
        595                 600                 605             


Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly 
    610                 615                 620                 


Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly 
625                 630                 635                 640 


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
                645                 650                 655     


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
            660                 665                 670         


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
        675                 680                 685             


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695                 700                 


<210>  262
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Sru_DnaB

<400>  262

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Gly Lys 
            100                 105                 110         


Gly Thr Pro Val Met Met Tyr Asp Gly Arg Thr Lys Pro Val Glu Lys 
        115                 120                 125             


Val Glu Val Gly Asp Arg Leu Met Gly Asp Asp Gly Ser Pro Arg Thr 
    130                 135                 140                 


Val Gln Ser Leu Ala Arg Gly Arg Glu Gln Met Tyr Trp Val Arg Gln 
145                 150                 155                 160 


Lys Arg Gly Met Asp Tyr Arg Val Asn Glu Ser His Ile Leu Ser Leu 
                165                 170                 175     


Lys Lys Ser Arg Arg Glu Gly Ala Arg Asp Arg Gly Ser Ile Ala Asp 
            180                 185                 190         


Ile Ser Val Arg Asp Tyr Leu Asp Gln Ser Asp Lys Trp Lys Asp Asp 
        195                 200                 205             


Asn Lys Gly Phe Lys Val Ala Ala Glu Phe Pro Asp Gln Pro Val Pro 
    210                 215                 220                 


Leu Asp Pro Tyr Phe Leu Gly Leu Trp Leu Gly Asp Gly Lys Ser Asp 
225                 230                 235                 240 


Asn Ala Arg Ile Tyr Thr Thr Asp Glu Glu Val Ile Thr Gly Leu Gln 
                245                 250                 255     


Glu Ile Ala Glu Lys Arg Gly Asp Thr Ile Ser Val Ser Asp Glu His 
            260                 265                 270         


Arg Arg Cys Pro Ala Tyr Leu Val Lys Ser Gly Asp Arg Gly Gly Ala 
        275                 280                 285             


Met Ala Thr Arg Glu Ser Val Gln Gly Ala Leu Arg Ala Leu Gly Val 
    290                 295                 300                 


Leu Gly Asp Lys His Ile Pro His Leu Tyr Leu Gly Asn Ser Arg Gly 
305                 310                 315                 320 


Lys Arg Leu Arg Leu Leu Ala Gly Leu Ile Asp Ser Asp Gly His Leu 
                325                 330                 335     


Asn Asp Gly His Gly Gly Thr Tyr Glu Ile Thr Gln Ser Ser Glu Gln 
            340                 345                 350         


Leu Ala Arg Asp Ile Lys Phe Leu Cys Asp Thr Leu Gly Tyr Arg Thr 
        355                 360                 365             


Ser Leu Thr Gln Lys Thr Ala Arg Ile Ser Ser Thr Gly Tyr Glu Ser 
    370                 375                 380                 


Glu Val His Arg Val Arg Phe Asn Gly Asn Val Asp Glu Ile Pro Val 
385                 390                 395                 400 


Arg Val Glu Arg Lys Lys Ala Ser Pro Trp Thr Asp Val Arg Asp Trp 
                405                 410                 415     


Arg Met Thr Gly Ile Asp Val Glu Pro Asp Gly Val Gly Asp Tyr Phe 
            420                 425                 430         


Gly Phe Thr Leu Asp Gly Asn Gly Arg Phe Leu Leu Gly Asp Gly Thr 
        435                 440                 445             


Val Thr His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
    450                 455                 460                 


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
465                 470                 475                 480 


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
                485                 490                 495     


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
            500                 505                 510         


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
        515                 520                 525             


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
    530                 535                 540                 


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
545                 550                 555                 560 


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
                565                 570                 575     


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
            580                 585                 590         


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
        595                 600                 605             


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
    610                 615                 620                 


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
625                 630                 635                 640 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
                645                 650                 655     


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
            660                 665                 670         


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
        675                 680                 685             


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695             


<210>  263
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Sru_PolBc

<400>  263

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Asp Pro 
            100                 105                 110         


Glu Thr Glu Val Val Thr Val Asp Gly Ile Arg His Val Glu Glu Ile 
        115                 120                 125             


Glu Val Gly Asp Arg Val Tyr Ser Leu Asn Pro Asp Thr Gly Ala Val 
    130                 135                 140                 


Glu Ile Lys Pro Val Thr Ala Thr Gln Ser Gln His Tyr Ala Gly Pro 
145                 150                 155                 160 


Met Val Glu Ile Lys Asn Gln His Thr Asp Phe Leu Val Thr Pro Asn 
                165                 170                 175     


His Arg Phe Leu Thr Gln Arg Phe Thr Ser Gly Glu Tyr Thr Asp Leu 
            180                 185                 190         


Glu Trp Glu Thr Ala Gly Asp Met Leu Gly Asp Arg Ile Arg Arg Arg 
        195                 200                 205             


Leu Pro Ser Leu Arg Ser Leu Pro Ala Thr Gln Glu Arg Pro Gly Pro 
    210                 215                 220                 


Ile Ser Leu Ser Ala Val Cys Asp Arg Leu Ala Ile Glu His Lys Thr 
225                 230                 235                 240 


Gly Pro Arg Gly Ile Lys Glu Leu Arg Arg Gln Ala Arg Trp Gln Pro 
                245                 250                 255     


Glu Glu Tyr Glu Leu Thr Asp Trp Leu Arg Ile Leu Gly Trp Phe Ala 
            260                 265                 270         


Thr Glu Gly Thr Leu Tyr Lys Ser Lys Ala Arg Gln Tyr Glu Asn Gly 
        275                 280                 285             


Asn Val Arg Gly Val Ser Tyr Gln Thr Thr Leu Cys Gln Lys Asn Asp 
    290                 295                 300                 


Ile Gly Arg Ser Glu Ile Ala Thr Leu Leu Asn Arg Thr Gly Ile Thr 
305                 310                 315                 320 


Tyr Ser Ser Asp Gln Asn Asp His Ser Phe Cys Ser Lys Val Leu Tyr 
                325                 330                 335     


Glu Ile Leu Glu Ala Glu Cys Gly Ser Asp Ser Phe Ser Lys His Leu 
            340                 345                 350         


Pro Pro Trp Ile Phe Gln Leu Gly Pro Lys Asp Leu Lys Ile Val Phe 
        355                 360                 365             


Asp Thr Leu Met Gln Gly Asp Ser Ala Ala Asn Gly Asp Arg Phe Thr 
    370                 375                 380                 


Thr Ser Ser Asn Gln Leu Ala Glu Asp Phe Ile Arg Leu Ala Met His 
385                 390                 395                 400 


Ile Gly Arg Arg Ala Phe His Met Pro Asn Asp Gly Ser His Arg Ile 
                405                 410                 415     


Gln Val Asn Thr Val Arg Gly Gln Arg Pro Thr Ile Lys Pro Lys His 
            420                 425                 430         


Arg Gln Gln Val Asp Tyr Asp Gly Met Ile His Cys Leu Thr Val Ala 
        435                 440                 445             


Asp Asn His Thr Val Leu Ala Gly Arg Asn Arg Lys Phe Asn Trp Thr 
    450                 455                 460                 


Gly Gln Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
465                 470                 475                 480 


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
                485                 490                 495     


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
            500                 505                 510         


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
        515                 520                 525             


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
    530                 535                 540                 


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
545                 550                 555                 560 


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
                565                 570                 575     


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
            580                 585                 590         


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
        595                 600                 605             


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
    610                 615                 620                 


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
625                 630                 635                 640 


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
                645                 650                 655     


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            660                 665                 670         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        675                 680                 685             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    690                 695                 700                 


Val Asn Ala Glu Ala Ala Thr Arg 
705                 710         


<210>  264
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ssp_DnaB

<400>  264

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Ile Ser Gly 
            100                 105                 110         


Asp Ser Leu Ile Ser Leu Ala Ser Thr Gly Lys Arg Val Ser Ile Lys 
        115                 120                 125             


Asp Leu Leu Asp Glu Lys Asp Phe Glu Ile Trp Ala Ile Asn Glu Gln 
    130                 135                 140                 


Thr Met Lys Leu Glu Ser Ala Lys Val Ser Arg Val Phe Cys Thr Gly 
145                 150                 155                 160 


Lys Lys Leu Val Tyr Ile Leu Lys Thr Arg Leu Gly Arg Thr Ile Lys 
                165                 170                 175     


Ala Thr Ala Asn His Arg Phe Leu Thr Ile Asp Gly Trp Lys Arg Leu 
            180                 185                 190         


Asp Glu Leu Ser Leu Lys Glu His Ile Ala Leu Pro Arg Lys Leu Glu 
        195                 200                 205             


Ser Ser Ser Leu Gln Leu Met Ser Asp Glu Glu Leu Gly Leu Leu Gly 
    210                 215                 220                 


His Leu Ile Gly Asp Gly Cys Thr Leu Pro Arg His Ala Ile Gln Tyr 
225                 230                 235                 240 


Thr Ser Asn Lys Ile Glu Leu Ala Glu Lys Val Val Glu Leu Ala Lys 
                245                 250                 255     


Ala Val Phe Gly Asp Gln Ile Asn Pro Arg Ile Ser Gln Glu Arg Gln 
            260                 265                 270         


Trp Tyr Gln Val Tyr Ile Pro Ala Ser Tyr Arg Leu Thr His Asn Lys 
        275                 280                 285             


Lys Asn Pro Ile Thr Lys Trp Leu Glu Asn Leu Asp Val Phe Gly Leu 
    290                 295                 300                 


Arg Ser Tyr Glu Lys Phe Val Pro Asn Gln Val Phe Glu Gln Pro Gln 
305                 310                 315                 320 


Arg Ala Ile Ala Ile Phe Leu Arg His Leu Trp Ser Thr Asp Gly Cys 
                325                 330                 335     


Val Lys Leu Ile Val Glu Lys Ser Ser Arg Pro Val Ala Tyr Tyr Ala 
            340                 345                 350         


Thr Ser Ser Glu Lys Leu Ala Lys Asp Val Gln Ser Leu Leu Leu Lys 
        355                 360                 365             


Leu Gly Ile Asn Ala Arg Leu Ser Lys Ile Ser Gln Asn Gly Lys Gly 
    370                 375                 380                 


Arg Asp Asn Tyr His Val Thr Ile Thr Gly Gln Ala Asp Leu Gln Ile 
385                 390                 395                 400 


Phe Val Asp Gln Ile Gly Ala Val Asp Lys Asp Lys Gln Ala Ser Val 
                405                 410                 415     


Glu Glu Ile Lys Thr His Ile Ala Gln His Gln Ala Asn Thr Asn Arg 
            420                 425                 430         


Asp Val Ile Pro Lys Gln Ile Trp Lys Thr Tyr Val Leu Pro Gln Ile 
        435                 440                 445             


Gln Ile Lys Gly Ile Thr Thr Arg Asp Leu Gln Met Arg Leu Gly Asn 
    450                 455                 460                 


Ala Tyr Cys Gly Thr Ala Leu Tyr Lys His Asn Leu Ser Arg Glu Arg 
465                 470                 475                 480 


Ala Ala Lys Ile Ala Thr Ile Thr Gln Ser Pro Glu Ile Glu Lys Leu 
                485                 490                 495     


Ser Gln Ser Asp Ile Tyr Trp Asp Ser Ile Val Ser Ile Thr Glu Thr 
            500                 505                 510         


Gly Val Glu Glu Val Phe Asp Leu Thr Val Pro Gly Pro His Asn Phe 
        515                 520                 525             


Val Ala Asn Asp Ile Ile Val His Asn Ser Gly Val Lys Val Ala Val 
    530                 535                 540                 


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
545                 550                 555                 560 


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
                565                 570                 575     


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
            580                 585                 590         


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
        595                 600                 605             


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
    610                 615                 620                 


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
625                 630                 635                 640 


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
                645                 650                 655     


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
            660                 665                 670         


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
        675                 680                 685             


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
    690                 695                 700                 


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
705                 710                 715                 720 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
                725                 730                 735     


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
            740                 745                 750         


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
        755                 760                 765             


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780             


<210>  265
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ssp_GyrB

<400>  265

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ser Gly 
            100                 105                 110         


Asp Thr Leu Val Ala Leu Thr Asp Gly Arg Ser Val Ser Phe Glu Gln 
        115                 120                 125             


Leu Val Glu Glu Glu Lys Gln Gly Lys Gln Asn Phe Cys Tyr Thr Ile 
    130                 135                 140                 


Arg His Asp Gly Ser Ile Gly Val Glu Lys Ile Ile Asn Ala Arg Lys 
145                 150                 155                 160 


Thr Lys Thr Asn Ala Lys Val Ile Lys Val Thr Leu Asp Asn Gly Glu 
                165                 170                 175     


Ser Ile Ile Cys Thr Pro Asp His Lys Phe Met Leu Arg Asp Gly Ser 
            180                 185                 190         


Tyr Lys Cys Ala Met Asp Leu Thr Leu Asp Asp Ser Leu Met Pro Leu 
        195                 200                 205             


His Arg Lys Ile Ser Thr Thr Glu Asp Ser Gly Ile Thr Ile Asp Gly 
    210                 215                 220                 


Tyr Glu Met Val Trp Ser Pro Arg Ser Asp Ser Trp Leu Phe Thr His 
225                 230                 235                 240 


Leu Val Ala Asp Trp Tyr Asn Arg Trp Gln Gly Ile Tyr Ile Ala Glu 
                245                 250                 255     


Glu Lys Gln His Cys His His Lys Asp Phe Asn Lys Arg Asn Asn Asn 
            260                 265                 270         


Pro Asp Asn Leu Ile Arg Leu Ser Pro Glu Lys His Leu Ala Leu His 
        275                 280                 285             


Arg Lys His Ile Ser Lys Thr Leu His Arg Pro Asp Val Val Glu Lys 
    290                 295                 300                 


Cys Arg Arg Ile His Gln Ser Pro Glu Phe Arg Arg Lys Met Ser Ala 
305                 310                 315                 320 


Arg Met Gln Ser Pro Glu Thr Arg Ala Ile Leu Ser Lys Gln Ala Gln 
                325                 330                 335     


Ala Gln Trp Gln Asn Glu Thr Tyr Lys Leu Thr Met Met Glu Ser Trp 
            340                 345                 350         


Arg Ser Phe Tyr Asp Ser Asn Glu Asp Tyr Arg Gln Gln Asn Ala Glu 
        355                 360                 365             


Gln Leu Asn Arg Ala Gln Gln Glu Tyr Trp Ala Gln Ala Glu Asn Arg 
    370                 375                 380                 


Thr Ala Gln Ala Glu Arg Val Arg Gln His Phe Ala Gln Asn Pro Gly 
385                 390                 395                 400 


Leu Arg Gln Gln Tyr Ser Glu Asn Ala Val Lys Gln Trp Asn Asn Pro 
                405                 410                 415     


Glu Leu Leu Lys Trp Arg Gln Lys Lys Thr Lys Glu Gln Trp Thr Pro 
            420                 425                 430         


Glu Phe Arg Glu Lys Arg Arg Glu Ala Leu Ala Gln Thr Tyr Tyr Arg 
        435                 440                 445             


Lys Thr Leu Ala Ala Leu Lys Gln Val Glu Ile Glu Asn Gly Tyr Leu 
    450                 455                 460                 


Asp Ile Ser Ala Tyr Asp Ser Tyr Arg Ile Ser Thr Lys Asp Lys Ser 
465                 470                 475                 480 


Leu Leu Arg Phe Asp Arg Phe Cys Glu Arg Tyr Phe Glu Asn Asp Glu 
                485                 490                 495     


Asn Leu Ala Arg Glu Ala Val Leu Asn Tyr Asn His Arg Ile Val Asn 
            500                 505                 510         


Ile Glu Ala Val Ser Glu Thr Ile Asp Val Tyr Asp Ile Glu Val Pro 
        515                 520                 525             


His Thr His Asn Phe Ala Leu Ala Ser Gly Val Phe Val His Asn Ser 
    530                 535                 540                 


Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp 
545                 550                 555                 560 


Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr 
                565                 570                 575     


Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala 
            580                 585                 590         


Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu 
        595                 600                 605             


Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser 
    610                 615                 620                 


Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala 
625                 630                 635                 640 


Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala 
                645                 650                 655     


Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly 
            660                 665                 670         


Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
        675                 680                 685             


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
    690                 695                 700                 


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
705                 710                 715                 720 


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
                725                 730                 735     


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
            740                 745                 750         


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
        755                 760                 765             


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
    770                 775                 780                 


Glu Ala Ala Thr Arg 
785                 


<210>  266
<211>  774
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:StP-Twort_ORF6

<400>  266

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Ile Ser Met 
            100                 105                 110         


Asp Ser Met Ile Leu Thr Thr Glu Gly Tyr Lys Ser Leu Gln Glu Ile 
        115                 120                 125             


Phe Glu Thr Gln Gly Val Lys Val Asp Asn Lys Glu Lys Val Ile Glu 
    130                 135                 140                 


Leu Lys Tyr Pro Leu Ile Asn Arg Tyr Gly Asp Val Glu Tyr Thr Ser 
145                 150                 155                 160 


His Phe Thr Lys Asn Gly Glu Lys Pro Thr Lys Arg Ile Lys Thr Asn 
                165                 170                 175     


Lys Gly Ile Glu Leu Val Asn Thr Tyr Asn His Pro Leu Leu Val Arg 
            180                 185                 190         


Glu Gly Phe Asn Leu Ile Trp Lys Lys Ser Glu Asp Ile Glu Val Gly 
        195                 200                 205             


Asp Ile Leu Val Ser Arg Val Gly Asp His Gln Phe Gly Asn Asn Asn 
    210                 215                 220                 


Thr Val Glu Asn Glu Glu Glu Ala Tyr Ala Leu Gly Cys Met Val Ala 
225                 230                 235                 240 


Asp Ser Tyr Leu Gly Ser Tyr Ser Arg Leu Ser Phe Ser Asn Asp Lys 
                245                 250                 255     


Lys Glu Ile Leu Asp Lys Val Ser Lys Phe Trp Asn Thr Phe Ser Asn 
            260                 265                 270         


Lys Glu Val Tyr Tyr Asp Thr Tyr Lys Glu Ser Lys Gly Ile Thr Ile 
        275                 280                 285             


His Leu His Asp Thr Asn Lys Thr Lys Glu Phe His Asp Lys Tyr Lys 
    290                 295                 300                 


Ile Glu Tyr Gly Val Ala Lys Asp Lys Lys Ile Pro Lys Cys Ile Met 
305                 310                 315                 320 


Glu Ser Pro Glu Asn Ile Gln Leu Ala Phe Val Ser Gly Tyr Leu Glu 
                325                 330                 335     


Cys Glu Ser Ser Ile Ser Glu Lys Asn Leu Glu Val Thr Ser Ala Ser 
            340                 345                 350         


Lys Asp Leu Leu Lys Asp Leu Gln Leu Ile Leu Ser Asn Ile Gly Ile 
        355                 360                 365             


Val Ser Thr Asn Lys Glu Lys Val Val Lys Lys Tyr Lys His Asn Lys 
    370                 375                 380                 


Tyr Tyr Arg Leu Ile Val Asn Arg Lys Glu Leu Ile Lys Leu Leu Pro 
385                 390                 395                 400 


Leu Leu Arg Phe Glu Thr Gln Gln Arg Lys Asn Gln Lys Glu Asn Phe 
                405                 410                 415     


Leu Ser Asn Asn Thr Lys Ile Lys Ser Ser Tyr Gly Asn Thr Ile Glu 
            420                 425                 430         


Gly Ser Arg Tyr Leu Leu Lys Lys Tyr Arg Asp Ser Leu Asn Ile Asp 
        435                 440                 445             


Lys Lys Glu Phe Ser Lys Tyr Leu Ser Arg Asp Thr Ile Thr Ile Asp 
    450                 455                 460                 


Arg Leu Arg Glu Val Ile Ser Leu Tyr Pro Asp Gly Asp Lys Glu Ile 
465                 470                 475                 480 


Arg Glu Leu Phe Glu Asn Val Val Asn Asn Asn Ile Tyr Tyr Gln Lys 
                485                 490                 495     


Val Glu Gln Val Leu Glu Gly Glu Ile Ile Pro Thr Phe Asp Val Cys 
            500                 505                 510         


Met Pro Lys Thr His Ser Phe Ile Ala Asn Thr Ile Val Asn His Asn 
        515                 520                 525             


Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro 
    530                 535                 540                 


Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser 
545                 550                 555                 560 


Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala 
                565                 570                 575     


Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu 
            580                 585                 590         


Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser 
        595                 600                 605             


Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val 
    610                 615                 620                 


Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln 
625                 630                 635                 640 


Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser 
                645                 650                 655     


Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn 
            660                 665                 670         


Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe 
        675                 680                 685             


Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val 
    690                 695                 700                 


Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
705                 710                 715                 720 


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
                725                 730                 735     


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
            740                 745                 750         


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
        755                 760                 765             


Ala Glu Ala Ala Thr Arg 
    770                 


<210>  267
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Tag_Pol-1_Tsp-TY_Pol-1

<400>  267

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys His Pro Ala 
            100                 105                 110         


Asp Thr Lys Val Ile Val Lys Gly Lys Gly Ile Val Asn Ile Ser Asp 
        115                 120                 125             


Val Lys Glu Gly Asp Tyr Ile Leu Gly Ile Asp Gly Trp Gln Arg Val 
    130                 135                 140                 


Lys Lys Val Trp Lys Tyr His Tyr Glu Gly Lys Leu Ile Asn Ile Asn 
145                 150                 155                 160 


Gly Leu Lys Cys Thr Pro Asn His Lys Val Pro Val Val Thr Glu Asn 
                165                 170                 175     


Asp Arg Gln Thr Arg Ile Arg Asp Ser Leu Ala Lys Ser Phe Leu Ser 
            180                 185                 190         


Gly Lys Val Lys Gly Lys Ile Ile Thr Thr Lys Leu Phe Glu Lys Ile 
        195                 200                 205             


Ala Glu Phe Glu Lys Asn Lys Pro Ser Glu Glu Glu Ile Leu Lys Gly 
    210                 215                 220                 


Glu Leu Ser Gly Ile Ile Leu Ala Glu Gly Thr Leu Leu Arg Lys Asp 
225                 230                 235                 240 


Ile Glu Tyr Phe Asp Ser Ser Arg Gly Lys Lys Arg Ile Ser His Gln 
                245                 250                 255     


Tyr Arg Val Glu Ile Thr Ile Gly Glu Asn Glu Lys Glu Leu Leu Glu 
            260                 265                 270         


Arg Ile Leu Tyr Ile Phe Asp Lys Leu Phe Gly Ile Arg Pro Ser Val 
        275                 280                 285             


Lys Lys Lys Gly Asp Thr Asn Ala Leu Lys Ile Thr Thr Ala Lys Lys 
    290                 295                 300                 


Ala Val Tyr Leu Gln Ile Glu Glu Leu Leu Lys Asn Ile Glu Ser Leu 
305                 310                 315                 320 


Tyr Ala Pro Ala Val Leu Arg Gly Phe Phe Glu Arg Asp Ala Thr Val 
                325                 330                 335     


Asn Lys Ile Arg Ser Thr Ile Val Val Thr Gln Gly Thr Asn Asn Lys 
            340                 345                 350         


Trp Lys Ile Asp Ile Val Ala Lys Leu Leu Asp Ser Leu Gly Ile Pro 
        355                 360                 365             


Tyr Ser Arg Tyr Glu Tyr Lys Tyr Ile Glu Asn Gly Lys Glu Leu Thr 
    370                 375                 380                 


Lys His Ile Leu Glu Ile Thr Gly Arg Asp Gly Leu Ile Leu Phe Gln 
385                 390                 395                 400 


Thr Leu Val Gly Phe Ile Ser Ser Glu Lys Asn Glu Ala Leu Glu Lys 
                405                 410                 415     


Ala Ile Glu Val Arg Glu Met Asn Arg Leu Lys Asn Asn Ser Phe Tyr 
            420                 425                 430         


Asn Leu Ser Thr Phe Glu Val Ser Ser Glu Tyr Tyr Lys Gly Glu Val 
        435                 440                 445             


Tyr Asp Leu Thr Leu Glu Gly Asn Pro Tyr Tyr Phe Ala Asn Gly Ile 
    450                 455                 460                 


Leu Thr His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
465                 470                 475                 480 


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
                485                 490                 495     


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
            500                 505                 510         


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
        515                 520                 525             


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
    530                 535                 540                 


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
545                 550                 555                 560 


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
                565                 570                 575     


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
            580                 585                 590         


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
        595                 600                 605             


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
    610                 615                 620                 


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
625                 630                 635                 640 


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
                645                 650                 655     


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
            660                 665                 670         


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
        675                 680                 685             


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
    690                 695                 700                 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
705                 710                 


<210>  268
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Tag_Pol-2_Tsp-TY_Pol-2_T134

<400>  268

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Ile Leu Pro 
            100                 105                 110         


Asn Glu Trp Leu Pro Ile Ile Glu Asn Gly Glu Val Lys Phe Val Lys 
        115                 120                 125             


Ile Gly Glu Phe Ile Asp Arg Tyr Met Glu Glu Gln Lys Asp Lys Val 
    130                 135                 140                 


Arg Thr Val Asp Asn Thr Glu Val Leu Glu Val Asp Asn Ile Phe Ala 
145                 150                 155                 160 


Phe Ser Leu Asn Lys Glu Ser Lys Lys Ser Glu Ile Lys Lys Val Lys 
                165                 170                 175     


Ala Leu Ile Arg His Lys Tyr Lys Gly Glu Ala Tyr Glu Val Glu Leu 
            180                 185                 190         


Asn Ser Gly Arg Lys Ile His Ile Thr Arg Gly His Ser Leu Phe Thr 
        195                 200                 205             


Ile Arg Asn Gly Lys Ile Lys Glu Ile Trp Gly Glu Glu Val Lys Val 
    210                 215                 220                 


Gly Asp Leu Ile Ile Val Pro Lys Lys Val Lys Leu Asn Glu Lys Glu 
225                 230                 235                 240 


Ala Val Ile Asn Ile Pro Glu Leu Ile Ser Lys Leu Pro Asp Glu Asp 
                245                 250                 255     


Thr Ala Asp Val Val Met Thr Thr Pro Val Lys Gly Arg Lys Asn Phe 
            260                 265                 270         


Phe Lys Gly Met Leu Arg Thr Leu Lys Trp Ile Phe Gly Glu Glu Ser 
        275                 280                 285             


Lys Arg Ile Arg Thr Phe Asn Arg Tyr Leu Phe His Leu Glu Glu Leu 
    290                 295                 300                 


Gly Phe Val Lys Leu Leu Pro Arg Gly Tyr Glu Val Thr Asp Trp Glu 
305                 310                 315                 320 


Gly Leu Lys Arg Tyr Arg Gln Leu Tyr Glu Lys Leu Val Lys Asn Leu 
                325                 330                 335     


Arg Tyr Asn Gly Asn Lys Arg Glu Tyr Leu Val Arg Phe Asn Asp Ile 
            340                 345                 350         


Lys Asp Ser Val Ser Cys Phe Pro Arg Lys Glu Leu Glu Glu Trp Lys 
        355                 360                 365             


Ile Gly Thr Arg Lys Gly Phe Arg Arg Lys Cys Ile Leu Lys Val Asp 
    370                 375                 380                 


Glu Asp Phe Gly Lys Phe Leu Gly Tyr Tyr Val Ser Glu Gly Tyr Ala 
385                 390                 395                 400 


Gly Ala Gln Lys Asn Lys Thr Gly Gly Met Ser Tyr Ser Val Lys Leu 
                405                 410                 415     


Tyr Asn Glu Asn Pro Asn Val Leu Lys Asp Met Lys Asn Ile Ala Glu 
            420                 425                 430         


Lys Phe Phe Gly Lys Val Arg Val Gly Lys Asn Cys Val Asp Ile Pro 
        435                 440                 445             


Lys Lys Met Ala Tyr Leu Leu Ala Lys Ser Leu Cys Gly Val Thr Ala 
    450                 455                 460                 


Glu Asn Lys Arg Ile Pro Ser Ile Ile Phe Asp Ser Ser Glu Pro Val 
465                 470                 475                 480 


Arg Trp Ala Phe Leu Arg Ala Tyr Phe Val Gly Asp Gly Asp Ile His 
                485                 490                 495     


Pro Ser Lys Arg Leu Arg Leu Ser Thr Lys Ser Glu Leu Leu Ala Asn 
            500                 505                 510         


Gln Leu Val Phe Leu Leu Asn Ser Leu Gly Val Ser Ser Ile Lys Ile 
        515                 520                 525             


Gly Phe Asp Ser Gly Val Tyr Arg Val Tyr Ile Asn Glu Asp Leu Pro 
    530                 535                 540                 


Phe Leu Gln Thr Ser Arg Gln Lys Asn Thr Tyr Tyr Pro Asn Leu Ile 
545                 550                 555                 560 


Pro Lys Glu Val Leu Glu Glu Ile Phe Gly Arg Lys Phe Gln Lys Asn 
                565                 570                 575     


Ile Thr Phe Glu Lys Phe Lys Glu Leu Ala Asp Ser Gly Lys Leu Asp 
            580                 585                 590         


Lys Arg Lys Val Lys Leu Leu Asp Phe Leu Leu Asn Gly Asp Ile Val 
        595                 600                 605             


Leu Asp Arg Val Lys Asn Val Glu Lys Arg Glu Tyr Glu Gly Tyr Val 
    610                 615                 620                 


Tyr Asp Leu Ser Val Glu Asp Asn Glu Asn Phe Leu Val Gly Phe Gly 
625                 630                 635                 640 


Leu Leu Tyr Ala His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
                645                 650                 655     


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
            660                 665                 670         


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
        675                 680                 685             


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
    690                 695                 700                 


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
705                 710                 715                 720 


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
                725                 730                 735     


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
            740                 745                 750         


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
        755                 760                 765             


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
    770                 775                 780                 


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
785                 790                 795                 800 


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
                805                 810                 815     


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
            820                 825                 830         


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
        835                 840                 845             


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
    850                 855                 860                 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
865                 870                 875                 880 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                885                 890         


<210>  269
<211>  2340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ter_DnaB-1

<400>  269

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Ala Ala Tyr 
            100                 105                 110         


Asp Thr Leu Val Leu Gln Lys Asp Gly Ser Leu Val Thr Leu Ala Glu 
        115                 120                 125             


Val Tyr Lys Arg Gln Glu Ile Glu Leu Leu Thr Leu Gly Lys Asn Ser 
    130                 135                 140                 


Lys Phe Tyr Leu Thr Lys Pro Ser Ala Phe Ile Asp Asp Gly Ile Lys 
145                 150                 155                 160 


Pro Ile Phe Arg Val Thr Thr Lys Leu Gly Arg Phe Val Glu Thr Thr 
                165                 170                 175     


Ile Thr His Pro Phe Leu Thr Val Asn Gly Trp Lys Pro Leu Ser Lys 
            180                 185                 190         


Leu Gln Val Gly Glu Lys Ile Ala Val Pro Arg Arg Leu Asn Ile Phe 
        195                 200                 205             


Gly Asn Glu Thr Ile Ser Glu Ser Lys Phe Ser Ser Leu Ile Asn Phe 
    210                 215                 220                 


Asp Asn Leu Tyr Leu Phe Pro Leu Val Phe Gln Leu Glu Arg Ser Gln 
225                 230                 235                 240 


Leu Ala Leu Phe Ile Arg Tyr Leu Phe Ser Leu Asp Gly Trp Val Lys 
                245                 250                 255     


Ile Tyr Gln Asn Lys Ile Val Cys Phe Gly Tyr Ser Thr Val Ser Glu 
            260                 265                 270         


Lys Leu Ile Arg Gln Ile Gln His Ile Leu Leu Arg Phe Gly Ile Val 
        275                 280                 285             


Ser Gly Ile Glu Lys Phe Glu Glu Lys Arg Thr Glu Lys Ile Lys Val 
    290                 295                 300                 


Val Lys Glu Val Lys Ser Gln Arg Ser His Arg Glu Glu Phe Thr Phe 
305                 310                 315                 320 


Ala Thr Tyr Arg Asn Cys Tyr Cys Asp Gly Lys Trp His Leu Thr Ile 
                325                 330                 335     


Thr Asp Ala Leu Ser Gln Lys Asn Leu Met Glu Asp Ile Gly Gly Phe 
            340                 345                 350         


Asp Ser Lys Asn Phe Tyr Leu Phe Asp Leu Leu Gln Pro His Asn Ser 
        355                 360                 365             


Gly Asn Gln Glu Leu Glu Asn His Leu Ile Phe Trp Asp Glu Leu Val 
    370                 375                 380                 


Asn Val Leu Ala Lys Phe Ala Ala Ser Lys Asn Gln Ser Leu Lys Asn 
385                 390                 395                 400 


Arg Thr Ala Lys Gly Lys Ser Pro Lys Asn Ser Glu Asn Leu Thr Thr 
                405                 410                 415     


Thr Glu Thr Ile Cys Arg Lys Asn Ile Leu Ala Asn Met Glu Asn Leu 
            420                 425                 430         


Pro Ser Asp Asn Gln Asn Phe Asp Ser Glu Lys Leu Asp Leu Ser Gln 
        435                 440                 445             


Pro His Asn Ser Gly Asn Gln Glu Leu Glu Asn His Leu Ile Phe Trp 
    450                 455                 460                 


Asp Glu Leu Val Asn Val Leu Ala Lys Phe Ala Thr Ser Lys Asn Gln 
465                 470                 475                 480 


Ser Leu Lys Asn Arg Thr Thr Lys Arg Asn Ser Pro Lys Asn Ser Glu 
                485                 490                 495     


Asn Leu Thr Thr Thr Glu Thr Ile Cys Arg Lys Asn Ile Leu Ala Asn 
            500                 505                 510         


Met Glu Asn Leu Pro Ser Asp Asn Gln Asn Phe Asp Ser Glu Lys Leu 
        515                 520                 525             


Asp Leu Pro Gln Pro His Asn Ser Gly Asn Gln Glu Leu Glu Asn His 
    530                 535                 540                 


Leu Ile Phe Trp Asp Glu Leu Val Asn Val Leu Ala Lys Phe Ala Ala 
545                 550                 555                 560 


Ser Lys Asn Gln Ser Leu Lys Asn Arg Thr Thr Lys Arg Asn Ser Pro 
                565                 570                 575     


Lys Asn Ser Glu Asn Leu Thr Thr Thr Glu Thr Ile Cys Arg Lys Asn 
            580                 585                 590         


Ile Leu Ala Asn Met Glu Asn Leu Pro Ser Asp Asn Gln Asn Phe Asp 
        595                 600                 605             


Ser Glu Lys Leu Asp Leu Pro Gln Pro His Asn Ser Gly Asn Gln Glu 
    610                 615                 620                 


Leu Glu Asn His Leu Ile Phe Trp Asp Glu Leu Val Asn Val Leu Ala 
625                 630                 635                 640 


Lys Phe Ala Thr Ser Lys Asn Gln Ser Leu Lys Asn Arg Thr Thr Lys 
                645                 650                 655     


Arg Asn Ser Pro Lys Asn Ser Glu Asn Leu Thr Thr Thr Glu Thr Ile 
            660                 665                 670         


Cys Arg Lys Asn Ile Leu Ala Asn Met Glu Asn Leu Pro Ser Asp Asn 
        675                 680                 685             


Gln Asn Phe Asp Ser Glu Lys Leu Asp Leu Ser Gln Pro His Asn Ser 
    690                 695                 700                 


Gly Thr Gln Glu Leu Glu Asn His Leu Ile Phe Trp Asp Glu Leu Val 
705                 710                 715                 720 


Asn Val Leu Ala Lys Phe Ala Ala Ser Lys Asn Gln Ser Leu Lys Asn 
                725                 730                 735     


Arg Thr Ala Lys Gly Lys Ser Pro Lys Asn Ser Glu Asn Leu Thr Thr 
            740                 745                 750         


Thr Glu Thr Ile Cys Arg Lys Asn Ile Leu Ala Asn Met Glu Asn Leu 
        755                 760                 765             


Pro Ser Asp Asn Gln Asn Phe Asp Ser Glu Lys Leu Asp Leu Ser Gln 
    770                 775                 780                 


Pro His Asn Ser Gly Asn Gln Glu Leu Glu Asn His Leu Ile Phe Trp 
785                 790                 795                 800 


Asp Glu Leu Val Asn Val Leu Ala Lys Phe Ala Thr Ser Lys Asn Gln 
                805                 810                 815     


Ser Leu Lys Asn Arg Thr Thr Lys Arg Asn Ser Pro Lys Asn Ser Glu 
            820                 825                 830         


Asn Leu Thr Thr Thr Glu Thr Ile Cys Arg Lys Asn Ile Leu Ala Asn 
        835                 840                 845             


Met Glu Asn Leu Pro Ser Asp Asn Gln Asn Phe Asp Ser Glu Lys Leu 
    850                 855                 860                 


Asp Leu Pro Gln Pro His Asn Ser Gly Asn Gln Glu Leu Glu Asn His 
865                 870                 875                 880 


Leu Ile Phe Trp Asp Glu Leu Val Asn Val Leu Ala Lys Phe Ala Thr 
                885                 890                 895     


Ser Lys Asn Gln Ser Leu Lys Asn Arg Thr Thr Lys Arg Asn Ser Pro 
            900                 905                 910         


Lys Asn Ser Glu Asn Leu Thr Thr Thr Glu Thr Ile Cys Arg Lys Asn 
        915                 920                 925             


Ile Leu Ala Asn Met Glu Asn Leu Pro Ser Asp Asn Gln Asn Phe Asp 
    930                 935                 940                 


Ser Glu Lys Leu Asp Leu Pro Gln Pro His Asn Ser Gly Asn Gln Glu 
945                 950                 955                 960 


Leu Glu Asn His Leu Ile Phe Trp Asp Glu Leu Val Asn Val Leu Ala 
                965                 970                 975     


Lys Phe Ala Thr Ser Lys Asn Gln Ser Leu Lys Asn Arg Thr Thr Lys 
            980                 985                 990         


Arg Asn Ser Pro Lys Asn Ser Glu  Asn Leu Thr Thr Thr  Glu Thr Ile 
        995                 1000                 1005             


Cys Arg  Lys Asn Ile Leu Ala  Asn Met Glu Asn Leu  Pro Ser Asp 
    1010                 1015                 1020             


Asn Gln  Asn Phe Asp Ser Glu  Lys Leu Asp Leu Pro  Gln Pro His 
    1025                 1030                 1035             


Asn Ser  Gly Asn Gln Glu Leu  Glu Asn His Leu Ile  Phe Trp Asp 
    1040                 1045                 1050             


Glu Leu  Val Asn Val Leu Ala  Lys Phe Ala Thr Ser  Lys Asn Gln 
    1055                 1060                 1065             


Ser Leu  Lys Asn Arg Thr Thr  Lys Arg Asn Ser Pro  Lys Asn Ser 
    1070                 1075                 1080             


Glu Asn  Leu Thr Thr Thr Glu  Thr Ile Cys Arg Lys  Asn Ile Leu 
    1085                 1090                 1095             


Ala Asn  Met Glu Asn Leu Pro  Ser Asp Asn Gln Asn  Phe Asp Ser 
    1100                 1105                 1110             


Glu Lys  Leu Asp Leu Pro Gln  Pro His Asn Ser Gly  Asn Gln Glu 
    1115                 1120                 1125             


Leu Glu  Asn His Leu Ile Phe  Trp Asp Glu Leu Val  Asn Val Leu 
    1130                 1135                 1140             


Ala Lys  Phe Ala Thr Ser Lys  Asn Gln Ser Leu Lys  Asn Arg Thr 
    1145                 1150                 1155             


Thr Lys  Arg Asn Ser Pro Lys  Asn Ser Glu Asn Leu  Thr Thr Thr 
    1160                 1165                 1170             


Glu Thr  Ile Cys Arg Lys Asn  Ile Leu Ala Asn Met  Glu Asn Leu 
    1175                 1180                 1185             


Pro Ser  Asp Asn Gln Asn Phe  Asp Ser Glu Lys Leu  Asp Leu Ser 
    1190                 1195                 1200             


Gln Pro  His Asn Ser Gly Thr  Gln Glu Leu Glu Asn  His Leu Ile 
    1205                 1210                 1215             


Phe Trp  Asp Glu Leu Val Asn  Val Leu Ala Lys Phe  Ala Ala Ser 
    1220                 1225                 1230             


Lys Asn  Gln Ser Leu Lys Asn  Arg Thr Thr Lys Arg  Asn Ser Pro 
    1235                 1240                 1245             


Lys Asn  Ser Glu Asn Leu Thr  Thr Thr Glu Thr Ile  Cys Arg Lys 
    1250                 1255                 1260             


Asn Ile  Leu Ala Asn Met Glu  Asn Leu Pro Ser Asp  Asn Gln Asn 
    1265                 1270                 1275             


Phe Asp  Ser Glu Lys Leu Asp  Leu Pro Gln Pro His  Asn Ser Gly 
    1280                 1285                 1290             


Thr Gln  Glu Leu Glu Asn His  Leu Ile Phe Trp Asp  Glu Leu Val 
    1295                 1300                 1305             


Asn Val  Leu Ala Lys Phe Ala  Ala Ser Lys Asn Gln  Ser Leu Lys 
    1310                 1315                 1320             


Asn Arg  Thr Thr Lys Arg Asn  Ser Pro Lys Asn Ser  Glu Asn Leu 
    1325                 1330                 1335             


Thr Thr  Thr Glu Thr Ile Cys  Arg Lys Asn Ile Leu  Ala Asn Met 
    1340                 1345                 1350             


Glu Asn  Leu Pro Ser Asp Asn  Gln Asn Phe Asp Ser  Glu Lys Leu 
    1355                 1360                 1365             


Asp Leu  Pro Gln Pro His Asn  Ser Gly Asn Gln Glu  Leu Glu Asn 
    1370                 1375                 1380             


His Leu  Ile Phe Trp Asp Glu  Leu Val Asn Val Leu  Ala Lys Phe 
    1385                 1390                 1395             


Ala Ala  Ser Lys Asn Gln Ser  Leu Lys Asn Arg Thr  Thr Lys Arg 
    1400                 1405                 1410             


Asn Ser  Pro Lys Asn Ser Glu  Asn Leu Thr Thr Thr  Glu Thr Ile 
    1415                 1420                 1425             


Cys Arg  Lys Asn Ile Leu Ala  Asn Met Glu Asn Leu  Pro Ser Asp 
    1430                 1435                 1440             


Asn Gln  Asn Phe Asp Ser Glu  Lys Leu Asp Leu Pro  Gln Pro His 
    1445                 1450                 1455             


Asn Ser  Gly Asn Gln Glu Leu  Glu Asn His Leu Ile  Phe Trp Asp 
    1460                 1465                 1470             


Glu Leu  Val Asn Val Leu Ala  Lys Phe Ala Thr Ser  Lys Asn Gln 
    1475                 1480                 1485             


Ser Leu  Lys Asn Arg Thr Thr  Lys Arg Asn Ser Pro  Lys Asn Ser 
    1490                 1495                 1500             


Glu Asn  Leu Thr Thr Thr Glu  Thr Ile Cys Arg Lys  Asn Ile Leu 
    1505                 1510                 1515             


Ala Asn  Met Glu Asn Leu Pro  Ser Asp Asn Gln Asn  Phe Asp Ser 
    1520                 1525                 1530             


Glu Lys  Leu Asp Leu Pro Gln  Pro His Asn Ser Gly  Asn Gln Glu 
    1535                 1540                 1545             


Leu Glu  Asn His Leu Ile Phe  Trp Asp Glu Leu Val  Asn Val Leu 
    1550                 1555                 1560             


Ala Lys  Phe Ala Thr Ser Lys  Asn Gln Ser Leu Lys  Asn Arg Thr 
    1565                 1570                 1575             


Ala Lys  Gly Lys Ser Pro Lys  Asn Ser Glu Asn Leu  Thr Thr Thr 
    1580                 1585                 1590             


Glu Thr  Ile Cys Arg Lys Asn  Ile Leu Ala Asn Met  Glu Asn Leu 
    1595                 1600                 1605             


Pro Ser  Asp Asn Gln Asn Phe  Asp Ser Glu Lys Leu  Asp Leu Pro 
    1610                 1615                 1620             


Gln Pro  His Asn Ser Gly Asn  Gln Glu Leu Glu Asn  His Leu Ile 
    1625                 1630                 1635             


Phe Trp  Asp Glu Leu Val Asn  Val Leu Ala Lys Phe  Ala Thr Ser 
    1640                 1645                 1650             


Lys Asn  Gln Ser Leu Lys Asn  Arg Thr Thr Lys Arg  Asn Ser Pro 
    1655                 1660                 1665             


Lys Asn  Ser Glu Asn Leu Thr  Thr Thr Glu Thr Ile  Cys Arg Lys 
    1670                 1675                 1680             


Asn Ile  Leu Ala Asn Met Glu  Asn Leu Pro Ser Asp  Asn Gln Asn 
    1685                 1690                 1695             


Phe Asp  Ser Glu Lys Leu Asp  Leu Pro Gln Pro His  Asn Ser Gly 
    1700                 1705                 1710             


Asn Gln  Glu Leu Glu Asn His  Leu Ile Phe Trp Asp  Glu Leu Val 
    1715                 1720                 1725             


Asn Val  Leu Ala Lys Phe Ala  Thr Ser Lys Asn Gln  Ser Leu Lys 
    1730                 1735                 1740             


Asn Arg  Thr Thr Lys Arg Asn  Ser Pro Lys Asn Ser  Glu Asn Leu 
    1745                 1750                 1755             


Thr Thr  Thr Glu Thr Ile Cys  Arg Lys Asn Ile Leu  Ala Asn Met 
    1760                 1765                 1770             


Glu Asn  Leu Pro Ser Asp Asn  Gln Asn Phe Asp Ser  Glu Lys Leu 
    1775                 1780                 1785             


Asp Leu  Pro Gln Pro His Asn  Ser Gly Asn Gln Glu  Leu Glu Asn 
    1790                 1795                 1800             


His Leu  Ile Phe Trp Asp Glu  Leu Val Asn Val Leu  Ala Lys Phe 
    1805                 1810                 1815             


Ala Thr  Ser Lys Asn Gln Ser  Leu Lys Asn Arg Thr  Ala Lys Gly 
    1820                 1825                 1830             


Lys Ser  Pro Lys Asn Ser Glu  Asn Leu Thr Thr Thr  Glu Thr Ile 
    1835                 1840                 1845             


Cys Arg  Lys Asn Ile Leu Ala  Asn Met Glu Asn Leu  Pro Ser Asp 
    1850                 1855                 1860             


Asn Gln  Asn Phe Asp Ser Glu  Lys Leu Asp Leu Pro  Gln Pro His 
    1865                 1870                 1875             


Asn Ser  Gly Asn Gln Glu Leu  Glu Asn His Leu Ile  Phe Trp Asp 
    1880                 1885                 1890             


Glu Leu  Val Asn Val Leu Ala  Lys Phe Ala Thr Ser  Lys Asn Gln 
    1895                 1900                 1905             


Ser Leu  Lys Asn Arg Thr Thr  Lys Arg Asn Ser Pro  Lys Asn Ser 
    1910                 1915                 1920             


Glu Asn  Leu Thr Thr Thr Glu  Thr Ile Cys Arg Lys  Asn Ile Leu 
    1925                 1930                 1935             


Ala Asn  Met Glu Asn Leu Pro  Ser Asp Asn Gln Asn  Phe Asp Ser 
    1940                 1945                 1950             


Glu Lys  Leu Asp Leu Pro Gln  Pro His Asn Ser Gly  Asn Gln Glu 
    1955                 1960                 1965             


Leu Glu  Asn His Leu Ile Phe  Trp Asp Glu Leu Val  Asn Val Leu 
    1970                 1975                 1980             


Ala Lys  Phe Ala Thr Ser Lys  Asn Gln Ser Leu Lys  Asn Arg Thr 
    1985                 1990                 1995             


Thr Lys  Arg Asn Ser Pro Lys  Asn Ser Glu Asn Leu  Thr Thr Thr 
    2000                 2005                 2010             


Glu Thr  Ile Cys Arg Lys Asn  Ile Leu Ala Asn Met  Glu Asn Leu 
    2015                 2020                 2025             


Pro Ser  Asp Asn Gln Asn Phe  Asp Ser Glu Lys Leu  Asp Leu Pro 
    2030                 2035                 2040             


Gln Pro  His Asn Ser Gly Thr  Gln Glu Leu Glu Asn  Ser Asp Ile 
    2045                 2050                 2055             


Phe Trp  Asp Lys Ile Val Ser  Ile Glu Pro Val Gly  Glu Lys Gln 
    2060                 2065                 2070             


Val Tyr  Asp Leu Thr Val Pro  Glu Thr His Asn Phe  Val Ala Asn 
    2075                 2080                 2085             


Asp Ile  Cys Leu His Asn Ser  Gly Val Lys Val Ala  Val Leu Asp 
    2090                 2095                 2100             


Thr Gly  Ile Ser Thr His Pro  Asp Leu Asn Ile Arg  Gly Gly Ala 
    2105                 2110                 2115             


Ser Phe  Val Pro Gly Glu Pro  Ser Thr Gln Asp Gly  Asn Gly His 
    2120                 2125                 2130             


Gly Thr  His Val Ala Gly Thr  Ile Ala Ala Leu Asn  Asn Ser Ile 
    2135                 2140                 2145             


Gly Val  Leu Gly Val Ala Pro  Ser Ala Glu Leu Tyr  Ala Val Lys 
    2150                 2155                 2160             


Val Leu  Gly Ala Ser Gly Ser  Gly Ser Val Ser Ser  Ile Ala Gln 
    2165                 2170                 2175             


Gly Leu  Glu Trp Ala Gly Asn  Asn Gly Met His Val  Ala Asn Leu 
    2180                 2185                 2190             


Ser Leu  Gly Ser Pro Ser Pro  Ser Ala Thr Leu Glu  Gln Ala Val 
    2195                 2200                 2205             


Asn Ser  Ala Thr Ser Arg Gly  Val Leu Val Val Ala  Ala Ser Gly 
    2210                 2215                 2220             


Asn Ser  Gly Ala Gly Ser Ile  Ser Tyr Pro Ala Arg  Tyr Ala Asn 
    2225                 2230                 2235             


Ala Met  Ala Val Gly Ala Thr  Asp Gln Asn Asn Asn  Arg Ala Ser 
    2240                 2245                 2250             


Phe Ser  Gln Tyr Gly Ala Gly  Leu Asp Ile Val Ala  Pro Gly Val 
    2255                 2260                 2265             


Asn Val  Gln Ser Thr Tyr Pro  Gly Ser Thr Tyr Ala  Ser Leu Asn 
    2270                 2275                 2280             


Gly Thr  Ser Met Ala Thr Pro  His Val Ala Gly Ala  Ala Ala Leu 
    2285                 2290                 2295             


Val Lys  Gln Lys Asn Pro Ser  Trp Ser Asn Val Gln  Ile Arg Asn 
    2300                 2305                 2310             


His Leu  Lys Asn Thr Ala Thr  Ser Leu Gly Ser Thr  Asn Leu Tyr 
    2315                 2320                 2325             


Gly Ser  Gly Leu Val Asn Ala  Glu Ala Ala Thr Arg  
    2330                 2335                 2340 


<210>  270
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ter_DnaE-2

<400>  270

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ser Gly 
            100                 105                 110         


Ser Thr Lys Val Ile Asp Ala Ala Thr Gly Asn Leu Phe Ser Leu Lys 
        115                 120                 125             


Glu Ile Ala Ala Gln Pro Glu Tyr Trp Leu Ser Arg Lys Val Phe Ser 
    130                 135                 140                 


Leu Asp Leu Lys Ser Gln Gln Val Val Gln Gln Pro Ile Thr Glu Ile 
145                 150                 155                 160 


His Pro Asn Gly Val Arg Asp Val Trp Gln Ile Thr Thr Arg Thr Asn 
                165                 170                 175     


Arg Lys Val Cys Ala Thr Asp Asp His Leu Phe Tyr Thr Val Leu Gly 
            180                 185                 190         


Trp Lys Pro Leu Lys Asp Phe Ser Val Gly Asp Arg Leu Gly Leu Pro 
        195                 200                 205             


Asn Lys Ile Pro Ile Asn Tyr Arg Ser Gln Ile Ser Asp Ser Lys Val 
    210                 215                 220                 


Lys Phe Thr Ala Tyr Leu Ile Gly Glu Gly Tyr Leu Tyr Thr Asn Ser 
225                 230                 235                 240 


Phe Ser Cys Ser Tyr Phe Cys Asn Ser Asp Gly Glu Leu Ile Ala Asp 
                245                 250                 255     


Phe Tyr Gly Cys Ala Glu Glu Leu Phe Gly Ser Ser Ala Pro Ile Glu 
            260                 265                 270         


Lys Gln Leu His Leu Gly Asn Lys Ser Val Ile Tyr Val Arg Ile Gly 
        275                 280                 285             


Leu Ile Ser Gly Leu Lys Asn Trp Val Asp Ser Tyr Leu Gln Cys Ala 
    290                 295                 300                 


Asn Ser Arg Val Gln Glu Ile Pro Asn Trp Ile Phe Ser Leu Ser Gln 
305                 310                 315                 320 


Ser Gln Leu Gln Leu Phe Leu Gly Ile Leu Trp Ser Thr Ser Gly Ile 
                325                 330                 335     


Phe Asp Glu Thr Ile Gly Tyr Thr Tyr Tyr Ser Ser Asn Ser Glu Val 
            340                 345                 350         


Leu Val Arg Gln Val Gln His Leu Phe Leu Arg Leu Gly Ile Val Ser 
        355                 360                 365             


Leu Phe Asn Val Asn Lys Val Lys Gly Gln Gly Glu Leu Asp Val Ser 
    370                 375                 380                 


Tyr Val Val Glu Val Arg Gly Arg Glu Asp Met Leu Lys Phe Tyr Lys 
385                 390                 395                 400 


Leu Ile Lys Pro Tyr Leu Ser Ser Tyr Lys Gln Gly Leu Cys Glu Ser 
                405                 410                 415     


Cys Tyr Leu Val Ile Lys Tyr Gln Gln Ser Tyr Gln Phe Lys Tyr Phe 
            420                 425                 430         


Leu Thr Pro Asp Phe Phe Asp Leu Ile Val Lys Ala Lys Lys Ala Ser 
        435                 440                 445             


Ser Met Thr Arg Ala Leu Gly Val Cys Gly Gly Glu Ile Ser Ser Val 
    450                 455                 460                 


Trp Asn Phe Gln Asn Thr Ser Asn Arg Ser Leu Ser Phe Asp Lys Phe 
465                 470                 475                 480 


Asn Asn Phe Ser Thr Val Leu Ala Asp Glu Glu Leu Thr Ala Ile Ala 
                485                 490                 495     


Asn Ser Asp Val Phe Trp Asp Glu Ile Ile Ser Ile Glu Tyr Ile Gly 
            500                 505                 510         


Lys Glu Glu Val Phe Asp Leu Thr Ile Pro Glu Thr His Asn Phe Ile 
        515                 520                 525             


Ala Asn Asp Phe Ile Val His Asn Ser Gly Val Lys Val Ala Val Leu 
    530                 535                 540                 


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
545                 550                 555                 560 


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
                565                 570                 575     


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
            580                 585                 590         


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
        595                 600                 605             


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
    610                 615                 620                 


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
625                 630                 635                 640 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
                645                 650                 655     


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
            660                 665                 670         


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
        675                 680                 685             


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
    690                 695                 700                 


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
705                 710                 715                 720 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
                725                 730                 735     


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
            740                 745                 750         


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
        755                 760                 765             


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780         


<210>  271
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Ter_DnaE-3nc_NC-terminal

<400>  271

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Tyr 
            100                 105                 110         


Glu Thr Glu Ile Met Thr Val Glu Tyr Gly Pro Leu Pro Ile Gly Lys 
        115                 120                 125             


Ile Val Glu Tyr Arg Ile Glu Cys Thr Val Tyr Thr Val Asp Lys Asn 
    130                 135                 140                 


Gly Tyr Ile Tyr Thr Gln Pro Ile Ala Gln Trp His Asn Arg Gly Met 
145                 150                 155                 160 


Gln Glu Val Tyr Glu Tyr Ser Leu Glu Asp Gly Thr Val Ile Arg Ala 
                165                 170                 175     


Thr Pro Glu His Lys Phe Met Thr Glu Asp Gly Gln Met Leu Pro Ile 
            180                 185                 190         


Asp Glu Ile Phe Glu Arg Asn Leu Asp Leu Lys Cys Leu Gly Thr Leu 
        195                 200                 205             


Glu Met Val Lys Ile Val Ser Arg Lys Leu Ala Lys Thr Glu Asn Val 
    210                 215                 220                 


Tyr Asp Ile Gly Val Thr Lys Asp His Asn Phe Val Leu Ala Asn Gly 
225                 230                 235                 240 


Leu Ile Ala Ser Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
                245                 250                 255     


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
            260                 265                 270         


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
        275                 280                 285             


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
    290                 295                 300                 


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
                325                 330                 335     


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
            340                 345                 350         


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
        355                 360                 365             


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
    370                 375                 380                 


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
385                 390                 395                 400 


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
                405                 410                 415     


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
            420                 425                 430         


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
        435                 440                 445             


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
    450                 455                 460                 


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
465                 470                 475                 480 


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                485                 490     


<210>  272
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ter_Ndse-2

<400>  272

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Leu Thr Gly 
            100                 105                 110         


Asp Gln Lys Val Leu Tyr Tyr Ile Ala Lys Lys Leu Tyr Tyr Glu Thr 
        115                 120                 125             


Phe Ala Glu Cys Tyr Asp Arg Ile Asn Gly Asp Ile Ser Ser Val Ser 
    130                 135                 140                 


Val Pro Cys Phe Asp Glu Asn Tyr Gln Thr Val Ile Lys Pro Ile Ser 
145                 150                 155                 160 


Ala Ile Trp Lys His His Val Lys Lys Lys Gly Phe Lys Ile Lys Ile 
                165                 170                 175     


Thr Trp Gly Lys Gln Ile Lys Ile Thr Glu Asp His Ser Leu Phe Thr 
            180                 185                 190         


Arg Asn Glu Asn Asn Lys Pro Gln Ala Val Phe Gly Asn Glu Ile Lys 
        195                 200                 205             


Val Gly Asp Glu Ile Gly Ile Pro Ser Tyr Ile Ser Phe Leu Glu Gln 
    210                 215                 220                 


Pro Leu Glu Pro Phe His Ile Thr Asp Lys Ile Leu Ile Gln Glu Glu 
225                 230                 235                 240 


Ile Tyr Val Glu Ser Glu Asp Thr Ile Ser Tyr Ile Glu Lys Tyr Gly 
                245                 250                 255     


Asp Lys Met Arg Glu Tyr Leu Leu Ala Lys Ser Leu Ser Pro Ser Gln 
            260                 265                 270         


Phe Tyr Ser Ile Leu Lys Thr Tyr Glu Ala Lys Asn Gln Ile Pro Trp 
        275                 280                 285             


His Leu Trp Lys Tyr Leu Glu Leu Pro Leu Ser Glu Lys Asp Lys Val 
    290                 295                 300                 


Cys Tyr Leu Ser Lys Lys Ala Ile Lys Asn Trp Ile Asp Asn Val Glu 
305                 310                 315                 320 


Glu Leu Leu Trp Phe Leu Gly Phe Tyr Val Ala Arg Gly Ser Leu Ile 
                325                 330                 335     


Lys Asn Glu Val Val Leu Lys Gly Glu Pro Ser Gln Leu Glu Lys Val 
            340                 345                 350         


Ile Glu Leu Ile Glu Arg Ile Phe Glu Tyr Lys Ser Glu Ile Asn Asp 
        355                 360                 365             


Ser Gly Tyr Ile Ser Ile Lys Ser Lys Ile Leu Val Asp Leu Ile Gly 
    370                 375                 380                 


Tyr Gly Leu Asn Phe Gly Asn Gln Glu Lys Asp Ile Pro Asn Trp Ile 
385                 390                 395                 400 


Leu Gln Leu Pro Glu Gln Gln Leu Ile Arg Phe Leu Lys Gly Phe Val 
                405                 410                 415     


Ala Gly Asn Asn Leu Glu Asn Gln Leu Asn Phe Tyr Leu Glu Phe Lys 
            420                 425                 430         


Thr Asp Ser Gln Leu Val Ala Glu Lys Leu Val Leu Ile Leu Ser Lys 
        435                 440                 445             


Phe Gly Leu Val Ala Asp Val Ser Glu Ile Glu Val Asn Glu Glu Asp 
    450                 455                 460                 


Ile Ala Lys Ile Tyr Arg Ile Ile Ile Glu Gly Leu Glu Asp Lys Asn 
465                 470                 475                 480 


Ile His Asn Leu Ser Lys Val Glu Gln Lys Ile Ser Ala Leu Thr Thr 
                485                 490                 495     


Gly Asp Ile Ala Trp Gly Lys Ile Glu Ser Ile Glu Glu Phe Glu Ile 
            500                 505                 510         


Asp Asp Tyr Val Tyr Asp Phe Ser Val Pro Asn Tyr Glu Asn Phe Ile 
        515                 520                 525             


Gly Gly Ser Tyr Asn Val Phe Ala His Asn Ser Gly Val Lys Val Ala 
    530                 535                 540                 


Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly 
545                 550                 555                 560 


Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly 
                565                 570                 575     


His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile 
            580                 585                 590         


Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val 
        595                 600                 605             


Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu 
    610                 615                 620                 


Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly 
625                 630                 635                 640 


Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr 
                645                 650                 655     


Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly 
            660                 665                 670         


Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala 
        675                 680                 685             


Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly 
    690                 695                 700                 


Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly 
705                 710                 715                 720 


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
                725                 730                 735     


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
            740                 745                 750         


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
        755                 760                 765             


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780                 


<210>  273
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ter_RIR1-3

<400>  273

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ser Gly 
            100                 105                 110         


Asp Thr Leu Leu Ile Thr Arg Asp Ser Ile His Lys Ile Lys Asp Val 
        115                 120                 125             


Val Gly Gln Lys Ile Glu Ile Trp Asn Gly Lys Asn Trp Ser Gln Val 
    130                 135                 140                 


Ile Pro Leu Lys Thr Gly Lys Asp Arg Lys Leu Tyr Arg Val Arg Phe 
145                 150                 155                 160 


Gly Asp Gly Ser Tyr Leu Asp Val Thr Glu Tyr His Arg Phe Phe Val 
                165                 170                 175     


Lys Asp Arg Phe Gly Lys Lys Tyr Glu Glu Val Gln Thr Lys Asp Leu 
            180                 185                 190         


Leu Thr His Ser Lys Tyr Ala Leu Asp Val Glu Pro Phe Ile Ile Asp 
        195                 200                 205             


Tyr His Asp Gly Asp Ser Ile Asn Leu Ser Tyr Ala Tyr Thr Leu Gly 
    210                 215                 220                 


Ala Ala Leu Gly Asn Gly Thr Ile Asp Gln Asn Ser Asn Gly Lys Ile 
225                 230                 235                 240 


Arg Val Tyr Ser His Lys Ala Glu Leu Ile Phe Ala Gly Asn Lys Ser 
                245                 250                 255     


Leu Glu Arg Gln Tyr Asn Tyr Leu Pro Ser Phe Val Asp Val Ile Asp 
            260                 265                 270         


Leu Gly Phe Ser Gly Glu Leu Leu Arg Arg Leu Gln Thr Glu Pro Asp 
        275                 280                 285             


Ala Leu Asn Thr Ile Ala Ser Trp Asn Lys Ser Ala Ile Leu Ala Phe 
    290                 295                 300                 


Ile Ala Gly Leu Ala Asp Thr Asp Gly Ser Glu Thr Lys Gly Asn Gly 
305                 310                 315                 320 


Ile Lys Ile Ser Val Ser Asp Tyr Glu Arg Ala Lys Arg Leu Gln Leu 
                325                 330                 335     


Leu Leu Thr Lys Cys Gly Ile Arg Ala Ser Val Asn Leu Met Ala Ser 
            340                 345                 350         


Arg Gly Cys Thr Thr Asn Leu Gly Glu Arg Asn Gln Asp Leu Tyr Tyr 
        355                 360                 365             


Leu Gln Ile Thr Asp Cys Arg Glu Ile Pro Cys Gln Arg Leu Asp Thr 
    370                 375                 380                 


Thr Lys Val Cys Glu Ala Lys Phe Gln Gly Lys Tyr Gln Thr Ile Gln 
385                 390                 395                 400 


Asn Val Glu Glu Leu Pro Gly Leu His Asp Thr Tyr Cys Phe Glu Glu 
                405                 410                 415     


Pro Glu Phe His Lys Gly Val Phe Gly Asn Ala Leu Thr Gly Asn Ser 
            420                 425                 430         


Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp 
        435                 440                 445             


Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr 
    450                 455                 460                 


Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala 
465                 470                 475                 480 


Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu 
                485                 490                 495     


Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser 
            500                 505                 510         


Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala 
        515                 520                 525             


Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala 
    530                 535                 540                 


Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly 
545                 550                 555                 560 


Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
                565                 570                 575     


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
            580                 585                 590         


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
        595                 600                 605             


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
    610                 615                 620                 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
625                 630                 635                 640 


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
                645                 650                 655     


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
            660                 665                 670         


Glu Ala Ala Thr Arg 
        675         


<210>  274
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ter_RIR1-4

<400>  274

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Asp Lys 
            100                 105                 110         


Thr Ala Leu Arg Ile Phe Asn Gln Gly Leu Leu Tyr Ala Asp Glu Val 
        115                 120                 125             


Val Thr Pro Gly Ser Gly Glu Thr Val Gly Leu Gly Leu Thr Val Arg 
    130                 135                 140                 


Asn Gly Ile Gly Ala Ser Thr Ala Ile Ala Asn Gln Pro Met Glu Leu 
145                 150                 155                 160 


Val Glu Ile Lys Leu Ala Asn Gly Arg Lys Leu Arg Met Thr Pro Asn 
                165                 170                 175     


His Arg Met Ser Val Lys Gly Lys Trp Ile His Ala Cys Asn Leu Lys 
            180                 185                 190         


Pro Gly Met Leu Leu Asp Tyr Ser Ile Gly Glu Tyr Gln Lys Arg Glu 
        195                 200                 205             


Asp Thr Leu Leu Ile Pro Leu Gln Leu Glu Asp Tyr Thr Glu Val Asn 
    210                 215                 220                 


Asn Ser Gln Thr Leu Gly His Asn Gly Gly Val Leu Thr Lys Lys Ile 
225                 230                 235                 240 


Met Thr Pro Ala Ser Met Thr Ser Asp Leu Ala Tyr Phe Leu Gly Cys 
                245                 250                 255     


Leu Phe Gly Asn Gly Cys Ile Val Gln Asn Lys Tyr Gln Val Cys Phe 
            260                 265                 270         


Tyr His Ser Arg Leu Asp Val Leu Tyr Gly Leu Gln Glu Lys Gly Lys 
        275                 280                 285             


Lys Leu Phe Gly Ile Lys Gly Ser Leu Asn Asp Phe Ala Asn Gly Arg 
    290                 295                 300                 


Phe Glu Leu Cys Phe Ala Ser Arg Gln Leu Phe Tyr Trp Leu His Leu 
305                 310                 315                 320 


Asn Gln Leu Val Lys Thr Gln Lys Ser Glu Asp Leu Glu Arg Ile Pro 
                325                 330                 335     


Leu Ser Leu Arg Arg Ser Ser Arg Val Thr Leu Leu Ser Phe Phe Cys 
            340                 345                 350         


Gly Leu Ile Asp Thr Asn Gly Tyr Val Pro Gln Asp Gly Lys Leu Ser 
        355                 360                 365             


Ile Ala Ser Ala Ser Ser Asp Phe Ile His Asn Leu Gln Gln Ile Gly 
    370                 375                 380                 


Glu Ser Ile Gly Leu Cys Phe Ser Ile Tyr Gln Asn Thr Lys Gly Glu 
385                 390                 395                 400 


Asn Leu Gln Asn Gln His Asn Asn Thr Trp Gly Leu Cys Leu Ser Pro 
                405                 410                 415     


Met Leu Ser Asn Val Asp Ala Leu Asp Tyr Leu Asn His Asn Ser Ile 
            420                 425                 430         


Lys Cys Gln Glu Gly Pro Val Val Ile Ser Lys Cys Val Leu Asn Tyr 
        435                 440                 445             


Ser Pro Tyr Lys Ile Glu Ser Val Asn Ile Gly Ala Val Cys Asp Tyr 
    450                 455                 460                 


Ser Tyr Asp Phe Ala Ile Glu Gly Ile Asn Asp Asn Asp Ser Trp Tyr 
465                 470                 475                 480 


Trp Gln Gly Ala Leu Lys Ser His Asn Ser Gly Val Lys Val Ala Val 
                485                 490                 495     


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
            500                 505                 510         


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
        515                 520                 525             


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
    530                 535                 540                 


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
545                 550                 555                 560 


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
                565                 570                 575     


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
            580                 585                 590         


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
        595                 600                 605             


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
    610                 615                 620                 


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
625                 630                 635                 640 


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
                645                 650                 655     


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
            660                 665                 670         


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
        675                 680                 685             


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
    690                 695                 700                 


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
705                 710                 715                 720 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730                 735 


<210>  275
<211>  823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Ter_Snf2

<400>  275

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Leu His 
            100                 105                 110         


Asp Thr Glu Ile Tyr Val Asn Gly Met Val Met Glu Ala Glu Gln Ile 
        115                 120                 125             


Trp Gln Ala Tyr Ala Gly Glu Ala Glu Phe Asp Gly Glu Gly Phe Trp 
    130                 135                 140                 


Thr Glu Pro Asn Lys Glu Leu Leu Val Asn Ser Leu Asp Glu Thr Thr 
145                 150                 155                 160 


Gly Lys Ile Val Phe Ala Arg Ile Arg Arg Leu Tyr Arg Gln Trp Val 
                165                 170                 175     


Arg Glu Lys Leu Arg Lys Val Arg Leu Lys Asp Gly Ser Ser Ile Thr 
            180                 185                 190         


Ile Thr Cys Arg His Lys Leu Phe Ile Arg Asp Ser Trp Lys Asn Asp 
        195                 200                 205             


Phe Gln Val Gly Asp Asp Val Cys Val Pro Ala Lys Leu Met Trp Asp 
    210                 215                 220                 


Gly Lys Pro Glu Asp Pro Asp Val Val Lys Phe Val Ala Trp Gln Val 
225                 230                 235                 240 


Ala Glu Gly Trp Glu Arg Val Asn Ser Gly Met Phe Gly Val Ser Gln 
                245                 250                 255     


Lys Gly Lys Asp Val Leu Glu Gly Leu Leu Glu Val Phe Ser Arg Leu 
            260                 265                 270         


Gly Lys Arg Tyr Asp Ile Lys Ile Asn Cys Pro Lys Val Val Ala His 
        275                 280                 285             


Gly Ser Lys Lys Asn Cys Tyr Glu Phe Ser Ala His Ser Leu Glu Tyr 
    290                 295                 300                 


Arg Lys Phe Leu Glu Glu Lys Arg Tyr Gly Trp Gly Lys Arg Ser His 
305                 310                 315                 320 


Glu Lys Thr Ile Pro Leu Phe Ile Met Gln Ala Asp Leu Asp Ser Val 
                325                 330                 335     


Arg Val Phe Leu Ser Asn Tyr Phe Asp Ala Glu Gly Trp Val Asn Lys 
            340                 345                 350         


Thr Val Arg Cys Val Glu Ile Ser Thr Ala Ser Ser Gln Leu Ile Gln 
        355                 360                 365             


Glu Leu Ser Ile Leu Leu Arg Arg Phe Gly Val Trp Met Lys Ile Ser 
    370                 375                 380                 


Pro Gln Gln Lys Cys Ala Thr Asn Gly Thr Gly Val Phe Cys Thr Tyr 
385                 390                 395                 400 


Tyr Ile Gly Thr Phe Gly Gly Asn Ser Ala Arg Cys Phe Leu Gln Glu 
                405                 410                 415     


Ile Gly Phe Asn Asp Ser Gly Lys Gln Glu Asn Leu Lys Ser Ile Cys 
            420                 425                 430         


Glu Lys Ile Ala Asp Ser Asn Val Glu Gly Ile Pro Ala Ser Asp Ile 
        435                 440                 445             


Val Ala Glu Leu Val Glu Lys Thr Gln Leu Pro Val Gly Ser Leu Gly 
    450                 455                 460                 


Ile Gln Asp Pro Ile Tyr Met Asp Gly Cys Gln Asp Phe Ser Pro Thr 
465                 470                 475                 480 


Ser Leu Glu Lys Val Ile Asn Ser Ile Glu Asp Ile Ile Ser Gly Ala 
                485                 490                 495     


Gly Glu Glu Glu Tyr Gly Gln Leu Lys Ser Ser Lys Leu Arg Asn Lys 
            500                 505                 510         


Thr Leu Glu Ala Tyr Ser Leu Leu Asn Ile Leu Glu Leu Glu Ile Tyr 
        515                 520                 525             


Lys Thr Arg Leu Gln Lys Leu Leu Asn Gln Glu Val Tyr Tyr Cys Gln 
    530                 535                 540                 


Ile Glu Ser Ile Glu Glu Met Glu Tyr Glu Gly Trp Val Tyr Asp Phe 
545                 550                 555                 560 


Glu Val Ser Lys Tyr His Asn Phe Val Ala Asn Asn Ile Ile Cys His 
                565                 570                 575     


Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
            580                 585                 590         


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
        595                 600                 605             


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
    610                 615                 620                 


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
625                 630                 635                 640 


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
                645                 650                 655     


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
            660                 665                 670         


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
        675                 680                 685             


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
    690                 695                 700                 


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
705                 710                 715                 720 


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
                725                 730                 735     


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
            740                 745                 750         


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
        755                 760                 765             


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
    770                 775                 780                 


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
785                 790                 795                 800 


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
                805                 810                 815     


Asn Ala Glu Ala Ala Thr Arg 
            820             


<210>  276
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tfu_Pol-2

<400>  276

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Val Thr Gly 
            100                 105                 110         


Asp Thr Glu Val Thr Ile Arg Arg Asn Gly Arg Ile Glu Phe Val Pro 
        115                 120                 125             


Ile Glu Lys Leu Phe Glu Arg Val Asp His Arg Val Gly Glu Lys Glu 
    130                 135                 140                 


Tyr Cys Val Leu Gly Gly Val Glu Ala Leu Thr Leu Asp Asn Arg Gly 
145                 150                 155                 160 


Arg Leu Val Trp Lys Lys Val Pro Tyr Val Met Arg His Lys Thr Asp 
                165                 170                 175     


Lys Arg Ile Tyr Arg Val Trp Phe Thr Asn Ser Trp Tyr Leu Asp Val 
            180                 185                 190         


Thr Glu Asp His Ser Leu Ile Gly Tyr Leu Asn Thr Ser Lys Val Lys 
        195                 200                 205             


Pro Gly Lys Pro Leu Lys Glu Arg Leu Val Glu Val Lys Pro Glu Glu 
    210                 215                 220                 


Leu Gly Gly Lys Val Lys Ser Leu Ile Thr Pro Asn Arg Pro Ile Ala 
225                 230                 235                 240 


Arg Thr Ile Lys Ala Asn Pro Ile Ala Val Lys Leu Trp Glu Leu Ile 
                245                 250                 255     


Gly Leu Leu Val Gly Asp Gly Asn Trp Gly Gly Gln Ser Asn Trp Ala 
            260                 265                 270         


Lys Tyr Tyr Val Gly Leu Ser Cys Gly Leu Asp Lys Ala Glu Ile Glu 
        275                 280                 285             


Arg Lys Val Leu Asn Pro Leu Arg Glu Ala Ser Val Ile Ser Asn Tyr 
    290                 295                 300                 


Tyr Asp Lys Ser Lys Lys Gly Asp Val Ser Ile Leu Ser Lys Trp Leu 
305                 310                 315                 320 


Ala Gly Phe Met Val Lys Tyr Phe Lys Asp Glu Asn Gly Asn Lys Ala 
                325                 330                 335     


Ile Pro Ser Phe Met Phe Asn Leu Pro Arg Glu Tyr Ile Glu Ala Phe 
            340                 345                 350         


Leu Arg Gly Leu Phe Ser Ala Asp Gly Thr Val Ser Leu Arg Arg Gly 
        355                 360                 365             


Ile Pro Glu Ile Arg Leu Thr Ser Val Asn Arg Glu Leu Ser Asp Ala 
    370                 375                 380                 


Val Arg Lys Leu Leu Trp Leu Val Gly Val Ser Asn Ser Leu Phe Thr 
385                 390                 395                 400 


Glu Thr Lys Pro Asn Arg Tyr Leu Glu Lys Glu Ser Gly Thr His Ser 
                405                 410                 415     


Ile His Val Arg Ile Lys Asn Lys His Arg Phe Ala Asp Arg Ile Gly 
            420                 425                 430         


Phe Leu Ile Asp Arg Lys Ser Thr Lys Leu Ser Glu Asn Leu Gly Gly 
        435                 440                 445             


His Thr Asn Lys Lys Arg Ala Tyr Lys Tyr Asp Phe Asp Leu Val Tyr 
    450                 455                 460                 


Pro Arg Lys Ile Glu Glu Ile Thr Tyr Asp Gly Tyr Val Tyr Asp Ile 
465                 470                 475                 480 


Glu Val Glu Gly Thr His Arg Phe Phe Ala Asn Gly Ile Leu Val His 
                485                 490                 495     


Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
            500                 505                 510         


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
        515                 520                 525             


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
    530                 535                 540                 


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
545                 550                 555                 560 


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
                565                 570                 575     


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
            580                 585                 590         


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
        595                 600                 605             


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
    610                 615                 620                 


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
625                 630                 635                 640 


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
                645                 650                 655     


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
            660                 665                 670         


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
        675                 680                 685             


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
    690                 695                 700                 


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
705                 710                 715                 720 


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
                725                 730                 735     


Asn Ala Glu Ala Ala Thr Arg 
            740             


<210>  277
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tfus_RecA-1

<400>  277

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Thr Ala 
            100                 105                 110         


Asp Thr Tyr Val Trp Thr Asp Arg Gly Leu Glu Thr Val Ala Glu Val 
        115                 120                 125             


Phe Gly Arg Ala Gly Leu Pro Leu Ser Ser Thr Ser Arg Val Thr Asp 
    130                 135                 140                 


Val Arg Asp Arg Asp Ile Arg Val Val Asn Glu Lys Gly Glu Leu Glu 
145                 150                 155                 160 


Gln Val Ala Ala Leu Thr His Asn Gly Arg Gln Pro Val Val Arg Ile 
                165                 170                 175     


Thr Val Ala Ser Gly Arg Gln Val Thr Val Thr Arg Asn His Pro Leu 
            180                 185                 190         


Arg Val Met Asn Asp Asp Gly Phe Ile Val Trp Arg Glu Ala Gly Gln 
        195                 200                 205             


Leu Arg Glu Gly Asp Val Leu Val Ser Ala Ala Phe Gly Ala Val Gln 
    210                 215                 220                 


Ala Ala Ser Gly Gly Gly Leu Ser Glu Asp Glu Ala Val Leu Leu Gly 
225                 230                 235                 240 


Tyr Leu Thr Ala Ala Gly Ser Leu Asp Pro Ala Gly His Val Cys Phe 
                245                 250                 255     


Thr Thr Thr Asp Ile Glu Thr Gly Ala Glu Phe Ala Ala Leu Ala Glu 
            260                 265                 270         


Trp Leu Leu Asp Thr Thr Val Thr Ala Val Pro Gly Asp Gly Gln Val 
        275                 280                 285             


Ala Tyr Val Leu Ser Asp Pro Ala Ala Arg His Thr Leu Ala Glu Arg 
    290                 295                 300                 


Tyr Gly Val Asp Tyr Ala Ala Ala Ala Arg Ile Pro Gln Cys Val Arg 
305                 310                 315                 320 


Thr Ala Gly Asp Lys Met Gln Arg Ala Phe Leu Ala Ala Leu Tyr Thr 
                325                 330                 335     


Ala Ala Gly Trp Thr Asp Thr Ser Ala Ala Val Gly Leu Arg Thr Ala 
            340                 345                 350         


Ser Ala Pro Leu Ala Arg Glu Val Gln Tyr Leu Leu Tyr Gly Leu Gly 
        355                 360                 365             


Ile Pro Ala Asp Leu Asp Arg Ser His Gly Asn Gly Gln His Pro Trp 
    370                 375                 380                 


Ala Val Thr Ile Ser Pro Ala Ala Ala Pro Arg Phe His Thr Glu Val 
385                 390                 395                 400 


Gly Phe Arg Thr Ala Gln Gln Ser Pro Gln Thr Gly Leu His Glu Pro 
                405                 410                 415     


Thr Pro Gln Val Glu Ala Ile Pro Asn Leu Thr Gly Leu Ile His Ala 
            420                 425                 430         


Leu Arg Asp Ser Ile Gly Asp Arg Ala Glu Ser Thr Asp Asp Pro Phe 
        435                 440                 445             


Pro Ala Ala Ser Gly Gly Ala Tyr Asp Arg Asp Gln Val Arg Arg Val 
    450                 455                 460                 


Ile Asp Trp Ala Lys Arg Arg Thr Asp Glu Ala Pro Ala Thr Ala Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Tyr Leu Thr Gln Leu Thr Asp Ala Arg Tyr Thr Tyr 
                485                 490                 495     


Glu Pro Ile Thr Ala Val Glu Asp Ala Gly Gln Gln Pro Thr Phe Asp 
            500                 505                 510         


Leu Met Val Pro Arg Thr His Ser Phe Leu Ala Asn Gly Ile Leu Ser 
        515                 520                 525             


His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
    530                 535                 540                 


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
545                 550                 555                 560 


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
                565                 570                 575     


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
            580                 585                 590         


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
        595                 600                 605             


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
    610                 615                 620                 


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
625                 630                 635                 640 


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
                645                 650                 655     


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
            660                 665                 670         


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
        675                 680                 685             


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
    690                 695                 700                 


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
705                 710                 715                 720 


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
                725                 730                 735     


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
            740                 745                 750         


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
        755                 760                 765             


Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775     


<210>  278
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tfus_RecA-2

<400>  278

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Met His Tyr 
            100                 105                 110         


Asp Thr Leu Val Thr Leu Ala Asp Gly Thr Gln Glu Lys Ile Gly Thr 
        115                 120                 125             


Ile Val Asp Arg Lys Leu Asp Val Glu Val Leu Ser Tyr Asp Pro Glu 
    130                 135                 140                 


Thr Asp Arg Ile Val Pro Arg Arg Val Val Asn Trp Phe Asp Asn Gly 
145                 150                 155                 160 


Ala Ala Asp His Phe Leu Gln Phe Thr Val Gly Arg Ser Gly Lys Pro 
                165                 170                 175     


Gly Gly Ala Gln Phe Thr Ala Thr Pro Asn His Leu Ile Arg Thr Pro 
            180                 185                 190         


Gly Gly Trp Arg Glu Ala Gly Glu Leu Ile Ala Gly Asp Arg Val Leu 
        195                 200                 205             


Val His Glu Pro His Tyr Leu Asn Glu Gln Gln Arg Gln Val Val Tyr 
    210                 215                 220                 


Gly Ser Leu Met Gly Arg Gly Thr Leu Val Pro Asp Arg His Gly Gly 
225                 230                 235                 240 


Pro Gly Val His Phe Cys Met Ala His Thr Ala Glu Gln Ala Ala Tyr 
                245                 250                 255     


Leu Asp Trp Lys Val Ser Leu Leu Gly Asn Ile Ala His Ser Arg Thr 
            260                 265                 270         


Ala Glu Ala Ser Ala Thr Val Gly Val Glu Phe Thr Pro Met Pro Glu 
        275                 280                 285             


Leu Ser Glu Leu His Arg Val Val Asp Phe Gly Asp Gly His Thr His 
    290                 295                 300                 


Leu Thr Trp Glu Phe Leu Lys Gln Leu Thr Pro Leu Ala Leu Ala Val 
305                 310                 315                 320 


Trp Tyr Leu Asp Ala Gly Thr Leu Thr Ile Pro Gln Ser Gly Thr Asp 
                325                 330                 335     


Asp Asp Ala Arg Val Gln Ile Asp Val Glu Thr Leu Ser Pro Gly Ser 
            340                 345                 350         


Arg Gln Arg Leu Val Glu Tyr Leu Arg Asp Thr His Glu Leu Asp Ala 
        355                 360                 365             


Ala Val Val Gln Gln Gly Ala Asp Ala Arg Ser Leu Leu Glu Phe Thr 
    370                 375                 380                 


Pro Ala Ala Thr Val Arg Phe Leu Glu Leu Val Ala Pro Tyr Val Pro 
385                 390                 395                 400 


Glu Ser Met Ser Ser Met Leu Leu Ala Gln Phe Arg Gly Arg Cys Ser 
                405                 410                 415     


Val Thr Pro Glu Tyr Ser Asp Pro Val Gln Arg Leu Val Ala Ala Pro 
            420                 425                 430         


Val Leu Asp Ile Gln Val Lys Pro Gly Ser Thr Arg Lys Phe Asp Ile 
        435                 440                 445             


Glu Val Glu Gly Asn His Asn Tyr Phe Val Asp Gly Val Met Val His 
    450                 455                 460                 


Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His 
465                 470                 475                 480 


Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro 
                485                 490                 495     


Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile 
            500                 505                 510         


Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala 
        515                 520                 525             


Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val 
    530                 535                 540                 


Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His 
545                 550                 555                 560 


Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu 
                565                 570                 575     


Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala 
            580                 585                 590         


Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala 
        595                 600                 605             


Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser 
    610                 615                 620                 


Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn 
625                 630                 635                 640 


Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
                645                 650                 655     


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
            660                 665                 670         


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
        675                 680                 685             


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
    690                 695                 700                 


Asn Ala Glu Ala Ala Thr Arg 
705                 710     


<210>  279
<211>  891
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Thy_Pol-1

<400>  279

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Leu Leu Pro 
            100                 105                 110         


Glu Glu Trp Ile Pro Leu Val Glu Asn Gly Lys Val Arg Leu His Arg 
        115                 120                 125             


Ile Gly Glu Phe Val Asp Lys Leu Met Glu Thr Asp Ser Glu Leu Val 
    130                 135                 140                 


Lys Arg Asn Gly Asp Thr Glu Val Leu Glu Val Arg Gly Ile Arg Ala 
145                 150                 155                 160 


Leu Ser Phe Asp Arg Lys Ser Lys Lys Ala Arg Val Met Pro Val Lys 
                165                 170                 175     


Ala Val Ile Arg His Arg Tyr Ser Gly Asp Val Tyr Glu Ile Val Leu 
            180                 185                 190         


Gly Ser Gly Arg Arg Ile Thr Val Thr Glu Gly His Ser Leu Phe Ala 
        195                 200                 205             


Tyr Gly Asp Gly Glu Leu Arg Glu Val Thr Gly Gly Glu Ile Lys Ala 
    210                 215                 220                 


Gly Asp Leu Leu Ala Val Pro Arg Arg Val Asn Leu Pro Glu Lys Lys 
225                 230                 235                 240 


Glu Arg Leu Asn Leu Val Glu Leu Leu Arg Arg Leu Pro Glu Glu Glu 
                245                 250                 255     


Thr Gly Asp Ile Ile Leu Thr Ile Pro Val Lys Gly Arg Lys Asn Phe 
            260                 265                 270         


Phe Lys Gly Met Leu Arg Thr Leu Arg Trp Ile Ser Gly Glu Glu Lys 
        275                 280                 285             


Arg Pro Arg Thr Ala Arg Arg Tyr Leu Glu His Leu Glu Gly Leu Gly 
    290                 295                 300                 


Tyr Val Arg Leu Lys Lys Ile Gly Tyr Glu Val Thr Asp Arg Glu Gly 
305                 310                 315                 320 


Leu Glu Arg Tyr Arg Lys Leu Tyr Glu Arg Leu Val Glu Ala Val Arg 
                325                 330                 335     


Tyr Asn Gly Asn Lys Arg Glu Tyr Leu Val Glu Phe Asn Ala Val Arg 
            340                 345                 350         


Asp Val Ile Ala Leu Met Pro Glu Glu Glu Leu Arg Asp Trp Leu Val 
        355                 360                 365             


Gly Thr Arg Asn Gly Phe Arg Met Arg Pro Phe Val Glu Ile Glu Glu 
    370                 375                 380                 


Asp Phe Ala Lys Leu Leu Gly Tyr Tyr Val Ser Glu Gly Asn Ala Arg 
385                 390                 395                 400 


Lys Trp Arg Asn Gln Lys Asn Gly Trp Ser Tyr Thr Val Lys Leu Tyr 
                405                 410                 415     


Asn Glu Asn Gln Arg Val Leu Asp Asp Met Glu Ser Leu Ala Glu Arg 
            420                 425                 430         


Phe Phe Gly Arg Val Lys Arg Gly Lys Asn Tyr Ile Glu Ile Pro Arg 
        435                 440                 445             


Lys Met Ala Tyr Ile Ile Phe Glu Asn Leu Cys Gly Thr Leu Ala Glu 
    450                 455                 460                 


Asn Lys Arg Val Pro Glu Ala Ile Phe Thr Ser Pro Glu Ser Val Arg 
465                 470                 475                 480 


Trp Ala Phe Ile Glu Gly Tyr Phe Ile Gly Asp Gly Asp Val His Pro 
                485                 490                 495     


Ser Lys Arg Val Arg Leu Ser Thr Lys Ser Glu Leu Leu Val Asn Gly 
            500                 505                 510         


Leu Val Leu Leu Leu Asn Ser Leu Gly Val Ser Ala Ile Lys Ile Arg 
        515                 520                 525             


His Asp Ser Gly Val Tyr Arg Val Tyr Val Asn Glu Glu Leu Pro Phe 
    530                 535                 540                 


Thr Asp Tyr Arg Lys Lys Lys Asn Ala Tyr Tyr Ser His Val Ile Pro 
545                 550                 555                 560 


Lys Glu Ile Leu Glu Glu Thr Phe Gly Lys Val Phe Gln Arg Ser Val 
                565                 570                 575     


Ser Tyr Glu Lys Phe Arg Glu Leu Val Lys Ser Glu Lys Leu Asp Gly 
            580                 585                 590         


Glu Lys Ala Lys Arg Ile Glu Trp Leu Leu Asn Gly Asp Val Val Leu 
        595                 600                 605             


Asp Lys Val Leu Glu Val Lys Lys Arg Pro Tyr Glu Gly Tyr Val Tyr 
    610                 615                 620                 


Asp Leu Ser Val Glu Glu Asp Glu Asn Phe Leu Ala Gly Phe Gly Leu 
625                 630                 635                 640 


Leu Tyr Ala His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
                645                 650                 655     


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
            660                 665                 670         


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
        675                 680                 685             


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
    690                 695                 700                 


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
705                 710                 715                 720 


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
                725                 730                 735     


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
            740                 745                 750         


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
        755                 760                 765             


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
    770                 775                 780                 


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
785                 790                 795                 800 


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
                805                 810                 815     


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
            820                 825                 830         


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
        835                 840                 845             


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
    850                 855                 860                 


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
865                 870                 875                 880 


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                885                 890     


<210>  280
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tko_CDC21-2

<400>  280

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Tyr His His 
            100                 105                 110         


Asp Phe Glu Leu Leu Leu Ala Asp Gly Arg Lys Val Lys Ile Gly Glu 
        115                 120                 125             


Leu Val Asp Lys Leu Ile Glu Lys Asn Arg Asp Arg Val Ile Leu Gly 
    130                 135                 140                 


Lys Asp Thr Glu Ile Leu Pro Val Glu Asp Ile Glu Leu Leu Ala Tyr 
145                 150                 155                 160 


Asp Leu Glu Lys Arg Glu Ile Val Lys Val Lys Ala Asp Arg Val Ser 
                165                 170                 175     


Arg His Lys Ala Pro Glu Arg Phe Ile Lys Leu Arg Phe Ser Asn Gly 
            180                 185                 190         


Arg Glu Ile Thr Val Thr Pro Glu His Pro Val Met Val Trp Glu Asn 
        195                 200                 205             


Gly Glu Ile Thr Glu Lys Pro Ala Glu Lys Ile Thr Pro Gly Asp Ile 
    210                 215                 220                 


Ala Leu Gly Val Leu Arg Tyr Pro Ile Gln Val Asp Gly Lys Phe Lys 
225                 230                 235                 240 


Glu Arg Tyr Arg Asp Met Arg Glu Ala Glu Asp Tyr Gln Asp Tyr Leu 
                245                 250                 255     


Tyr Ser Arg Gly Val Val Ser Lys Ile Lys Arg Thr Gly Ile Tyr Phe 
            260                 265                 270         


Thr Val Glu Lys Ala Arg Arg Ala Leu Pro Arg Glu Leu Val Lys Pro 
        275                 280                 285             


Leu Ile Asn Ala Gly Lys Ile Leu Arg Val Thr Gln Thr Pro Lys Glu 
    290                 295                 300                 


Arg Ala Ser Phe Asn Gln Lys Leu Val Arg Glu Asn Ile Ile Glu Gly 
305                 310                 315                 320 


Tyr Leu Gln Arg Ile Ile Glu Arg Met Asp Glu Leu Glu Arg Leu Ser 
                325                 330                 335     


Arg Glu Asp Pro Ala Lys Ala Leu Glu Leu Leu Pro Lys Thr Gln Leu 
            340                 345                 350         


Tyr Tyr Lys Tyr Gly Ile Thr Tyr Gly Lys Leu Lys Lys Leu Ala Glu 
        355                 360                 365             


Ala Arg Asn Ser Trp Ala Glu Gly Ile Ile Gln Ser Ala Val Ala Glu 
    370                 375                 380                 


Arg Ile Ser Leu Ala Lys Arg Glu Leu Glu Glu Phe Phe Lys Trp Trp 
385                 390                 395                 400 


Asn Ala Asn Val Asn Phe Leu Lys Val Lys Cys Val Glu Glu Ile Lys 
                405                 410                 415     


Asn Asp Arg Trp Glu Trp Val Tyr Asp Val Thr Val Glu Pro His His 
            420                 425                 430         


Leu Phe Val Ser His Gly Leu Val Leu His Asn Ser Gly Val Lys Val 
        435                 440                 445             


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
    450                 455                 460                 


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
465                 470                 475                 480 


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
                485                 490                 495     


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
            500                 505                 510         


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
        515                 520                 525             


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
    530                 535                 540                 


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
545                 550                 555                 560 


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
                565                 570                 575     


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
            580                 585                 590         


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
        595                 600                 605             


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
    610                 615                 620                 


Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
625                 630                 635                 640 


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
                645                 650                 655     


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
            660                 665                 670         


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
        675                 680                 685             


Arg 
    


<210>  281
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tko_Helicase

<400>  281

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Met His Pro 
            100                 105                 110         


Asp Thr Tyr Val Val Thr Lys Ser Gly Ala Lys Lys Val Ser Glu Leu 
        115                 120                 125             


Thr Glu Gly Asp Glu Val Leu Thr His Thr Gly Thr Phe Lys Lys Val 
    130                 135                 140                 


Ile Gln Pro Leu Arg Arg Glu His Lys Gly Arg Leu Leu Val Ile Lys 
145                 150                 155                 160 


Ala Tyr Gly Thr Val Pro Val Lys Ile Thr Pro Glu His Met Val Trp 
                165                 170                 175     


Val Val Lys Gln Ile Arg His Lys Ser His Tyr Ser Asp Gly Arg Gln 
            180                 185                 190         


Val Ile Trp Trp Glu Phe Glu Gly Pro Glu Trp Met Thr Ala Gln Glu 
        195                 200                 205             


Leu Lys Glu Arg Leu Glu Ser Glu Thr Asp Pro Lys Val Ser Tyr Met 
    210                 215                 220                 


Leu Leu Gln Pro Ile Pro Glu Pro Ser Val Asp Ala Asp Lys Ile Pro 
225                 230                 235                 240 


Leu Arg Lys Glu Val Tyr Val Val Asn Gln His Gly Lys Thr Asp Lys 
                245                 250                 255     


Leu His Pro Ser Val Lys Arg Thr Pro Glu Tyr Leu Pro Leu Asn Phe 
            260                 265                 270         


Glu Thr Ala Arg Leu Ile Gly Leu Trp Ile Ala Glu Gly Ser Thr Ser 
        275                 280                 285             


Lys Asn Gly Val Ile Lys Phe Asp Ile Ser Ser Asn Glu Glu Asp Leu 
    290                 295                 300                 


Thr Glu Phe Ile Thr Gly Thr Ile Arg Lys Tyr Phe Pro His Ala Lys 
305                 310                 315                 320 


Ile Val Val Lys Asp His Glu Arg Asn Arg Arg Thr Val Arg Phe Cys 
                325                 330                 335     


Asn Lys Arg Phe Ala Glu Trp Leu Arg Glu Asn Ile Gly His Gly Ala 
            340                 345                 350         


Asp Asn Lys Ser Ile Pro Pro Leu Leu Leu Leu Asn Lys Asn Arg Glu 
        355                 360                 365             


Val Arg Leu Gly Leu Leu Arg Gly Leu Ile Glu Gly Asp Gly Tyr Val 
    370                 375                 380                 


Arg Arg Glu Ser Gln Arg Arg Ala Asn Tyr Ile Ser Tyr Ser Thr Val 
385                 390                 395                 400 


Ser Pro Ser Leu Ala Tyr Gln Leu Gln Leu Leu Val Ala Ser Leu Gly 
                405                 410                 415     


Tyr Thr Ser Ser Ile His Arg Ser Ile Arg Thr Glu Gly Ile Gly Lys 
            420                 425                 430         


Thr Arg Lys Pro Ile Tyr Asp Val Lys Val Ser Gly Lys Ser Tyr Tyr 
        435                 440                 445             


Ser Leu Leu Glu Glu Leu Gly Phe Glu Val Pro Gln Arg Gly Asn Arg 
    450                 455                 460                 


Thr Tyr Asn Val Asn Arg Thr Trp Lys Asn Tyr Leu Leu Leu Lys Val 
465                 470                 475                 480 


Arg Ser Ile Glu Glu Glu Glu Tyr Glu Gly Asp Val Tyr Asn Leu Glu 
                485                 490                 495     


Val Glu Gly Asp Glu Ser Gly Ser Val Gly Phe Ile Val His Asn Ser 
            500                 505                 510         


Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp 
        515                 520                 525             


Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr 
    530                 535                 540                 


Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala 
545                 550                 555                 560 


Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu 
                565                 570                 575     


Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser 
            580                 585                 590         


Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala 
        595                 600                 605             


Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala 
    610                 615                 620                 


Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly 
625                 630                 635                 640 


Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
                645                 650                 655     


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
            660                 665                 670         


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
        675                 680                 685             


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
    690                 695                 700                 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
705                 710                 715                 720 


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
                725                 730                 735     


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
            740                 745                 750         


Glu Ala Ala Thr Arg 
        755         


<210>  282
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tko_IF2

<400>  282

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Leu Pro 
            100                 105                 110         


Asp Glu Lys Val Ile Leu Pro Glu His Gly Pro Ile Thr Leu Lys Gly 
        115                 120                 125             


Leu Phe Asp Leu Ala Lys Glu Thr Val Val Ala Asp Asn Glu Lys Glu 
    130                 135                 140                 


Ile Arg Lys Leu Gly Ala Lys Leu Thr Ile Val Gly Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Arg Val Leu Glu Ser Pro Tyr Val Trp Lys Val Arg His Arg Gly 
                165                 170                 175     


Lys Met Leu Arg Val Lys Leu Lys Asn Trp His Ser Val Ser Val Thr 
            180                 185                 190         


Pro Glu His Pro Phe Leu Thr Thr Arg Gly Trp Val Arg Ala Asp Gln 
        195                 200                 205             


Leu Lys Pro Gly Asp Tyr Val Ala Val Pro Arg Val Ile His Gly Asn 
    210                 215                 220                 


Glu Ser Asp Glu Arg Phe Val Ser Phe Val Tyr Glu Lys Leu Lys Asn 
225                 230                 235                 240 


Asp Glu Leu Ile Ala Lys Leu Arg Gly Glu Val Leu Ser Lys Ile Ser 
                245                 250                 255     


Ser Glu Phe Lys Gly Asp Arg Ala Tyr Lys Val Glu Arg Asn Val Phe 
            260                 265                 270         


Arg Trp Glu Asp Ile Glu Arg Leu Asn Leu Trp Asp Glu Val Glu Arg 
        275                 280                 285             


Val Ala Phe Thr Pro Arg Met His Arg Ser Gly Lys Pro Leu His Tyr 
    290                 295                 300                 


Val Lys Leu Pro Arg Ser Pro Glu Glu Trp Glu Ala Phe Phe Tyr Phe 
305                 310                 315                 320 


Ala Gly Val Met Phe Gly Asp Gly Ser Gln Asp Lys Ile Ala Asn Asn 
                325                 330                 335     


Asp Val Glu Val Tyr Glu Glu Leu Lys Lys Leu Ser Val Leu Gly Val 
            340                 345                 350         


Ala Val Lys Arg Val Glu Arg Thr Thr Ser Tyr Glu Ile Glu Leu Thr 
        355                 360                 365             


Asn Gly Lys Asn Ala Leu Leu Arg Leu Leu Arg Val Leu Phe Glu Tyr 
    370                 375                 380                 


Pro Glu Arg Gln Lys Ala Lys Ser Ile Arg Val Pro Arg Ile Leu Phe 
385                 390                 395                 400 


Ile Ala Pro Arg Lys Tyr Val Ser Arg Phe Leu Arg Gly Tyr Phe Asp 
                405                 410                 415     


Ala Asp Gly His Val Ser Leu Lys Asp Ala Arg Ile Glu Val Thr Ser 
            420                 425                 430         


Ala Ser Gln Glu Phe Leu Glu Asp Leu Ser Leu Leu Leu Leu Arg Phe 
        435                 440                 445             


Gly Ile Val Ser Lys Ile Tyr Arg Ser Asp Tyr Thr Thr Leu Val Ile 
    450                 455                 460                 


Ser Gly Arg Arg Asn Leu Asp Leu Phe Arg Arg Tyr Ile Gly Phe Ser 
465                 470                 475                 480 


Val Lys Asn Lys Ala Glu Ala Leu Glu Lys Ala Ile Lys Lys Ser Arg 
                485                 490                 495     


Arg Ser Glu Ser Tyr Pro Ile Phe Glu Glu Leu Lys Arg Leu Arg Leu 
            500                 505                 510         


Leu Phe Gly Phe Thr Arg Thr Glu Leu Asn Ser Asn Val Pro Phe Tyr 
        515                 520                 525             


Gly Lys Tyr Glu Ser Glu Glu Ala Pro Ser Tyr Glu Thr Leu Met Arg 
    530                 535                 540                 


Ile Leu Asp Ala Ile Glu Lys Gly Ser Ile Asn Leu Asp Lys Lys Ile 
545                 550                 555                 560 


Ala Val Leu Glu Gly Arg Ile Arg Asp His Asn Tyr Ile Lys Ala Phe 
                565                 570                 575     


Glu Lys Asp Gly Leu Ile Lys Asp Gly Lys Leu Thr Glu Leu Gly Arg 
            580                 585                 590         


Glu Leu Leu Glu Val Trp Arg Asn Arg Glu Phe Asp Ser Ser Asp Val 
        595                 600                 605             


Asp Tyr Ile Arg Asn Leu Ala Glu Asn Leu Val Phe Ile Pro Val Glu 
    610                 615                 620                 


Asp Ile Glu Glu Phe Glu Tyr Glu Gly Tyr Val Tyr Asp Val Thr Thr 
625                 630                 635                 640 


Glu Thr His Asn Phe Val Ala Asn Gly Ile Leu Val His Asn Ser Gly 
                645                 650                 655     


Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu 
            660                 665                 670         


Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln 
        675                 680                 685             


Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu 
    690                 695                 700                 


Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr 
705                 710                 715                 720 


Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile 
                725                 730                 735     


Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn 
            740                 745                 750         


Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val 
        755                 760                 765             


Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn 
    770                 775                 780                 


Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met 
785                 790                 795                 800 


Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln 
                805                 810                 815     


Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser 
            820                 825                 830         


Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
        835                 840                 845             


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
    850                 855                 860                 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
865                 870                 875                 880 


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
                885                 890                 895     


Ala Ala Thr Arg 
            900 


<210>  283
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tko_LHR

<400>  283

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ser Gly 
            100                 105                 110         


Asp Ser Lys Ile Leu Thr Gly Lys Gly Pro Val Glu Ile Gly Arg Leu 
        115                 120                 125             


Asn Ser Asn Met Ile Ala Gly Ile Trp Arg Phe Gln Thr Glu Leu Val 
    130                 135                 140                 


Arg Phe Glu Glu Pro His Arg Val Glu Tyr Arg Arg Glu Gly Val Lys 
145                 150                 155                 160 


Ile Arg Thr Arg Leu Gly Phe Glu Ile Lys Ala Thr Lys Glu His Lys 
                165                 170                 175     


Phe Leu Thr Val Asp Glu Asn Gly Glu Leu Arg Trp Val Glu Ala Trp 
            180                 185                 190         


Lys Leu Lys Glu Gly Asn Trp Val Gly Val Val Arg Arg Leu Pro Ser 
        195                 200                 205             


Pro Asn Val Lys Val Ser Ile Leu Asp Leu Leu Pro Pro Asn Ala Tyr 
    210                 215                 220                 


Leu Lys Leu Lys Gly Glu Phe Leu Arg Glu Leu Lys Leu Ser Ile Gln 
225                 230                 235                 240 


Ala Lys Phe Gly Ser Ile Arg Thr Tyr Ala Lys Lys Lys Arg Trp Ser 
                245                 250                 255     


Glu Ser Tyr Leu Val Lys Gln Leu Asn Gly Val Tyr Pro Phe Arg Trp 
            260                 265                 270         


Glu Arg Leu Ser Ala Val Leu Lys Asp Leu Asp Leu Arg Met Thr Glu 
        275                 280                 285             


Asn Asp Val Glu Arg Ile Thr Ser Asp Lys Gly Lys Tyr Ser Leu Pro 
    290                 295                 300                 


Ile Glu Phe Thr Pro Ser Met Ala Arg Leu Leu Gly Phe Trp Met Ala 
305                 310                 315                 320 


Asp Gly Ser Trp Lys Gly Gly Thr Leu Thr Leu Phe Ser Ser Asp Arg 
                325                 330                 335     


Lys Met Leu Glu Lys Tyr Lys Glu Leu Cys Lys Glu Glu Phe Gly Val 
            340                 345                 350         


Val Gly Arg Ile Arg Met Leu Asn Glu Ser Thr Tyr Ser Leu Glu Ile 
        355                 360                 365             


Ser Phe Asn Leu Leu Pro Ala Ile Phe Lys Asn Leu Thr Gly Asn Thr 
    370                 375                 380                 


Glu Arg Lys Ser Lys Leu Gly Thr Phe Pro Ser Ile Ile Tyr Ser Leu 
385                 390                 395                 400 


Pro Glu Glu His Lys Arg Glu Phe Leu Ala Gly Tyr Phe Asp Gly Asp 
                405                 410                 415     


Gly Phe Leu Glu Val Lys Gly Gly Arg Val Tyr Ser Ala Gly Phe Ser 
            420                 425                 430         


Thr Phe Asn Lys Arg Phe Ala Glu Gly Ile Arg Asp Ile Leu Leu Gln 
        435                 440                 445             


Leu Gly Ile Val Ser Ser Ile Arg Ala Arg Glu Tyr Asp Glu Val Gln 
    450                 455                 460                 


Lys Phe Lys Gly Arg Val Ile Pro Lys Lys Gly Ala Ser Tyr Thr Val 
465                 470                 475                 480 


Ser Val Leu Gly Gly Glu Tyr Leu Lys Arg Phe Phe Asp Ala Val Arg 
                485                 490                 495     


Pro Trp Arg Ser Asp Tyr Glu Gly Trp Glu Gly Met Tyr Asn Glu Gly 
            500                 505                 510         


Tyr Ser Asn Ser Asp Val Val Pro Asn Leu Gly Lys Arg Leu Arg Ser 
        515                 520                 525             


Ile Arg Glu Arg Leu Gly Ile Ser Ala Tyr Arg Met Ser Lys Met Gly 
    530                 535                 540                 


Phe Tyr Asn Pro Val Arg Val Glu Leu Gly Glu Arg Glu Ile Ser Arg 
545                 550                 555                 560 


Arg Asn Leu Arg Leu Leu Val Glu Phe Tyr Glu Arg Val Ala Lys Glu 
                565                 570                 575     


Lys Arg Val Glu Asp Val Leu Glu Glu Leu Ser Tyr Leu Arg Glu Leu 
            580                 585                 590         


Ala Glu Gly Asp Val Phe Phe Asp Arg Ile Thr Ser Val Glu Pro Ala 
        595                 600                 605             


Tyr Ile Asp Val Ala Tyr Gly Ile Ile Asn Ser Glu Thr Glu Asn Tyr 
    610                 615                 620                 


Ile Val Glu Gly Phe Ile Ser Lys Asn Ser Gly Val Lys Val Ala Val 
625                 630                 635                 640 


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
                645                 650                 655     


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
            660                 665                 670         


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
        675                 680                 685             


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
    690                 695                 700                 


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
705                 710                 715                 720 


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
                725                 730                 735     


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
            740                 745                 750         


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
        755                 760                 765             


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
    770                 775                 780                 


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
785                 790                 795                 800 


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
                805                 810                 815     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            820                 825                 830         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        835                 840                 845             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    850                 855                 860                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
865                 870                 875                 


<210>  284
<211>  890
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Tko_Pol-2_Pko_Pol-2

<400>  284

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Ile Leu Pro 
            100                 105                 110         


Glu Glu Trp Leu Pro Val Leu Glu Glu Gly Glu Val His Phe Val Arg 
        115                 120                 125             


Ile Gly Glu Leu Ile Asp Arg Met Met Glu Glu Asn Ala Gly Lys Val 
    130                 135                 140                 


Lys Arg Glu Gly Glu Thr Glu Val Leu Glu Val Ser Gly Leu Glu Val 
145                 150                 155                 160 


Pro Ser Phe Asn Arg Arg Thr Asn Lys Ala Glu Leu Lys Arg Val Lys 
                165                 170                 175     


Ala Leu Ile Arg His Asp Tyr Ser Gly Lys Val Tyr Thr Ile Arg Leu 
            180                 185                 190         


Lys Ser Gly Arg Arg Ile Lys Ile Thr Ser Gly His Ser Leu Phe Ser 
        195                 200                 205             


Val Arg Asn Gly Glu Leu Val Glu Val Thr Gly Asp Glu Leu Lys Pro 
    210                 215                 220                 


Gly Asp Leu Val Ala Val Pro Arg Arg Leu Glu Leu Pro Glu Arg Asn 
225                 230                 235                 240 


His Val Leu Asn Leu Val Glu Leu Leu Leu Gly Thr Pro Glu Glu Glu 
                245                 250                 255     


Thr Leu Asp Ile Val Met Thr Ile Pro Val Lys Gly Lys Lys Asn Phe 
            260                 265                 270         


Phe Lys Gly Met Leu Arg Thr Leu Arg Trp Ile Phe Gly Glu Glu Lys 
        275                 280                 285             


Arg Pro Arg Thr Ala Arg Arg Tyr Leu Arg His Leu Glu Asp Leu Gly 
    290                 295                 300                 


Tyr Val Arg Leu Lys Lys Ile Gly Tyr Glu Val Leu Asp Trp Asp Ser 
305                 310                 315                 320 


Leu Lys Asn Tyr Arg Arg Leu Tyr Glu Ala Leu Val Glu Asn Val Arg 
                325                 330                 335     


Tyr Asn Gly Asn Lys Arg Glu Tyr Leu Val Glu Phe Asn Ser Ile Arg 
            340                 345                 350         


Asp Ala Val Gly Ile Met Pro Leu Lys Glu Leu Lys Glu Trp Lys Ile 
        355                 360                 365             


Gly Thr Leu Asn Gly Phe Arg Met Arg Lys Leu Ile Glu Val Asp Glu 
    370                 375                 380                 


Ser Leu Ala Lys Leu Leu Gly Tyr Tyr Val Ser Glu Gly Tyr Ala Arg 
385                 390                 395                 400 


Lys Gln Arg Asn Pro Lys Asn Gly Trp Ser Tyr Ser Val Lys Leu Tyr 
                405                 410                 415     


Asn Glu Asp Pro Glu Val Leu Asp Asp Met Glu Arg Leu Ala Ser Arg 
            420                 425                 430         


Phe Phe Gly Lys Val Arg Arg Gly Arg Asn Tyr Val Glu Ile Pro Lys 
        435                 440                 445             


Lys Ile Gly Tyr Leu Leu Phe Glu Asn Met Cys Gly Val Leu Ala Glu 
    450                 455                 460                 


Asn Lys Arg Ile Pro Glu Phe Val Phe Thr Ser Pro Lys Gly Val Arg 
465                 470                 475                 480 


Leu Ala Phe Leu Glu Gly Tyr Ser Ser Ala Met Ala Thr Ser Thr Glu 
                485                 490                 495     


Gln Glu Thr Gln Ala Leu Asn Glu Lys Arg Ala Leu Ala Asn Gln Leu 
            500                 505                 510         


Val Leu Leu Leu Asn Ser Val Gly Val Ser Ala Val Lys Leu Gly His 
        515                 520                 525             


Asp Ser Gly Val Tyr Arg Val Tyr Ile Asn Glu Glu Leu Pro Phe Val 
    530                 535                 540                 


Lys Leu Asp Lys Lys Lys Asn Ala Tyr Tyr Ser His Val Ile Pro Lys 
545                 550                 555                 560 


Glu Val Leu Ser Glu Val Phe Gly Lys Val Phe Gln Lys Asn Val Ser 
                565                 570                 575     


Pro Gln Thr Phe Arg Lys Met Val Glu Asp Gly Arg Leu Asp Pro Glu 
            580                 585                 590         


Lys Ala Gln Arg Leu Ser Trp Leu Ile Glu Gly Asp Val Val Leu Asp 
        595                 600                 605             


Arg Val Glu Ser Val Asp Val Glu Asp Tyr Asp Gly Tyr Val Tyr Asp 
    610                 615                 620                 


Leu Ser Val Glu Asp Asn Glu Asn Phe Leu Val Gly Phe Gly Leu Val 
625                 630                 635                 640 


Tyr Ala His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
                645                 650                 655     


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
            660                 665                 670         


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
        675                 680                 685             


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
    690                 695                 700                 


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
705                 710                 715                 720 


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
                725                 730                 735     


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
            740                 745                 750         


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
        755                 760                 765             


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
    770                 775                 780                 


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
785                 790                 795                 800 


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
                805                 810                 815     


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
            820                 825                 830         


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
        835                 840                 845             


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
    850                 855                 860                 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
865                 870                 875                 880 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                885                 890 


<210>  285
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tko_RadA

<400>  285

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Lys 
            100                 105                 110         


Asp Thr Lys Val Tyr Tyr Glu Asn Asp Thr Leu Val His Phe Glu Ser 
        115                 120                 125             


Ile Glu Asp Met Tyr His Lys Tyr Ala Ser Leu Gly Arg Glu Val Pro 
    130                 135                 140                 


Phe Asp Asn Gly Tyr Ala Val Pro Leu Glu Thr Val Ser Val Tyr Thr 
145                 150                 155                 160 


Phe Asp Pro Lys Thr Gly Glu Val Lys Arg Thr Lys Ala Ser Tyr Ile 
                165                 170                 175     


Tyr Arg Glu Lys Val Glu Lys Leu Ala Glu Ile Arg Leu Ser Asn Gly 
            180                 185                 190         


Tyr Leu Leu Arg Ile Thr Leu Leu His Pro Val Leu Val Phe Arg Asn 
        195                 200                 205             


Gly Leu Gln Trp Val Pro Ala Gly Met Ile Lys Pro Gly Asp Leu Ile 
    210                 215                 220                 


Val Gly Ile Arg Ser Val Pro Ala Asn Ala Ala Thr Ile Glu Glu Ser 
225                 230                 235                 240 


Glu Ala Tyr Phe Leu Gly Leu Phe Val Ala Glu Gly Thr Ser Asn Pro 
                245                 250                 255     


Leu Ser Ile Thr Thr Gly Ser Glu Glu Leu Lys Asp Phe Ile Val Ser 
            260                 265                 270         


Phe Ile Glu Asp His Asp Gly Tyr Thr Pro Thr Val Glu Val Arg Arg 
        275                 280                 285             


Gly Leu Tyr Arg Ile Leu Phe Arg Lys Lys Thr Ala Glu Trp Leu Gly 
    290                 295                 300                 


Glu Leu Ala Thr Ser Asn Ala Ser Thr Lys Val Val Pro Glu Arg Val 
305                 310                 315                 320 


Leu Asn Ala Gly Glu Ser Ala Ile Ala Ala Phe Leu Ala Gly Tyr Leu 
                325                 330                 335     


Asp Gly Asp Gly Tyr Leu Thr Glu Ser Ile Val Glu Leu Val Thr Lys 
            340                 345                 350         


Ser Arg Glu Leu Ala Asp Gly Leu Val Phe Leu Leu Lys Arg Leu Gly 
        355                 360                 365             


Ile Thr Pro Arg Ile Ser Gln Lys Thr Ile Glu Gly Ser Val Tyr Tyr 
    370                 375                 380                 


Arg Ile Tyr Ile Thr Gly Glu Asp Arg Lys Thr Phe Glu Lys Val Leu 
385                 390                 395                 400 


Glu Lys Ser Arg Ile Lys Pro Gly Glu Met Asn Glu Gly Gly Val Gly 
                405                 410                 415     


Arg Tyr Pro Pro Ala Leu Gly Lys Phe Leu Gly Lys Leu Tyr Ser Glu 
            420                 425                 430         


Phe Arg Leu Pro Lys Arg Asp Asn Glu Thr Ala Tyr His Ile Leu Thr 
        435                 440                 445             


Arg Ser Arg Asn Val Trp Phe Thr Glu Lys Thr Leu Ser Arg Ile Glu 
    450                 455                 460                 


Glu Tyr Phe Arg Glu Ala Leu Glu Lys Leu Ser Glu Ala Arg Lys Ala 
465                 470                 475                 480 


Leu Glu Met Gly Asp Lys Pro Glu Leu Pro Phe Pro Trp Thr Ala Ile 
                485                 490                 495     


Thr Lys Tyr Gly Phe Thr Asp Arg Gln Val Ala Asn Tyr Arg Thr Arg 
            500                 505                 510         


Gly Leu Pro Lys Arg Pro Glu Leu Lys Glu Lys Val Val Ser Ala Leu 
        515                 520                 525             


Leu Lys Glu Ile Glu Arg Leu Glu Gly Val Ala Lys Leu Ala Leu Glu 
    530                 535                 540                 


Thr Ile Glu Leu Ala Arg Arg Leu Glu Phe His Glu Val Ser Ser Val 
545                 550                 555                 560 


Glu Val Val Asp Tyr Asn Asp Trp Val Tyr Asp Leu Val Ile Pro Glu 
                565                 570                 575     


Thr His Asn Phe Ile Ala Pro Asn Gly Leu Val Leu His Asn Ser Gly 
            580                 585                 590         


Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu 
        595                 600                 605             


Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln 
    610                 615                 620                 


Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu 
625                 630                 635                 640 


Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr 
                645                 650                 655     


Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile 
            660                 665                 670         


Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn 
        675                 680                 685             


Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val 
    690                 695                 700                 


Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn 
705                 710                 715                 720 


Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met 
                725                 730                 735     


Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln 
            740                 745                 750         


Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser 
        755                 760                 765             


Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
    770                 775                 780                 


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
785                 790                 795                 800 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
                805                 810                 815     


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
            820                 825                 830         


Ala Ala Thr Arg 
        835     


<210>  286
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tko_r-Gyr

<400>  286

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Pro 
            100                 105                 110         


Asp Thr Leu Val Ser Leu Ala Asp Gly Arg Ile Met Glu Ile Lys Asp 
        115                 120                 125             


Ala Val Glu Lys Ser Glu Gly Asn Leu Leu Ser Val Asn Gly Leu Lys 
    130                 135                 140                 


Pro Lys Glu Ala Lys Ala Leu Lys Phe Trp Glu Ile Asp Trp Asn Gly 
145                 150                 155                 160 


Pro Leu Lys Val Ile Lys Leu Lys Asn Gly His Glu Ile Lys Ala Thr 
                165                 170                 175     


Pro Asp His Gly Leu Leu Val Met Arg Glu Gly Lys Leu Gly Trp Val 
            180                 185                 190         


Ser Ala Lys Asn Val Arg Glu Gly Asp Tyr Val Ala Phe Ala Tyr Asn 
        195                 200                 205             


Thr Gly His Arg Gly Arg Asp Glu Tyr Thr Leu Leu Lys Leu Met Ile 
    210                 215                 220                 


Lys Leu Gly Ile Thr Asp Val Met Val Glu Leu Asp Glu Glu Tyr Phe 
225                 230                 235                 240 


Asn Glu Lys Val Ala Pro Ile Val Arg Glu Arg Ile Ser Thr Ser Thr 
                245                 250                 255     


Lys Tyr Lys Tyr Leu Arg Arg Arg Val Leu Pro Leu Tyr Leu Leu Gln 
            260                 265                 270         


Glu Trp Gly Leu Asp Asp Tyr Glu Ala His Val Lys Ser Leu Tyr Arg 
        275                 280                 285             


Gln Arg Ala Gly Ser Lys Pro Ile Pro Asn Phe Lys Leu Asp Gly Arg 
    290                 295                 300                 


Phe Trp Tyr Val Phe Gly Leu Val Leu Gly Asp Gly Thr Leu Arg Asp 
305                 310                 315                 320 


Ser Lys Val Leu Ile Ser Gln Thr Pro Leu Lys Asp Val Lys Ser Val 
                325                 330                 335     


Leu Glu Asp Val Phe Pro Phe Leu Arg Val Phe Glu Thr Thr Asn Gln 
            340                 345                 350         


Val Gly Phe Ser Asn Ser Ile Ile Ala Glu Val Phe Arg Arg Leu Gly 
        355                 360                 365             


Ala Arg Lys Gly Lys Leu His Pro Leu Val Phe Gly Leu Arg Glu Glu 
    370                 375                 380                 


Tyr Ile Asn Ala Met Ile Ala Gly Tyr Phe Asp Thr Asp Gly Thr Phe 
385                 390                 395                 400 


Ser Ile Leu Asn Asp Arg Lys Gly Pro Asn Phe Arg Gly Ile Leu Thr 
                405                 410                 415     


Ser Lys Arg Gly Asp Val Leu Arg Met Leu Ser Val Tyr Leu Tyr Gln 
            420                 425                 430         


Ile Gly Ile Met Asn Tyr Leu Arg Arg Asp Glu Arg Thr Gly Val Trp 
        435                 440                 445             


Asp Leu Ile Ile Ser Asn Arg Ser Leu Glu Lys Phe Arg Glu Lys Ile 
    450                 455                 460                 


Tyr Pro Tyr Leu Arg Ile Arg Arg Ala Gln Phe Asp Glu Ala Tyr Ser 
465                 470                 475                 480 


Val Tyr Arg Ala Ser Arg Arg Ala Phe Glu Gly Asp Leu Leu Pro Val 
                485                 490                 495     


Ala Pro Val Phe Gly Lys Leu Lys Phe Lys Asn Gly Thr Lys Asn Arg 
            500                 505                 510         


Ile Leu Lys Glu Thr Gly Ile Asp Val Trp Asn Trp Leu Lys Arg Pro 
        515                 520                 525             


Glu Gly Glu Ile Pro Arg Asp Lys Leu Ser Lys Val Leu Glu Tyr Ala 
    530                 535                 540                 


Glu Glu Ser Pro Glu Lys Glu Phe Leu Lys Ser Leu Val Glu Ala Gly 
545                 550                 555                 560 


Val Thr Trp Val Lys Val Lys Gly Val Glu Glu Glu Leu Tyr Thr Gly 
                565                 570                 575     


Lys Leu Tyr Asp Phe Thr Thr Thr Thr Glu Asn Phe Leu Ser Asn Gly 
            580                 585                 590         


Ala Val Ser His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
        595                 600                 605             


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
    610                 615                 620                 


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
625                 630                 635                 640 


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
                645                 650                 655     


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
            660                 665                 670         


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
        675                 680                 685             


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
    690                 695                 700                 


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
705                 710                 715                 720 


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
                725                 730                 735     


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
            740                 745                 750         


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
        755                 760                 765             


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
    770                 775                 780                 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
785                 790                 795                 800 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
                805                 810                 815     


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
            820                 825                 830         


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840             


<210>  287
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tko_RIR1-1

<400>  287

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Ile Asp Gly 
            100                 105                 110         


Asn Ala Lys Ile Ile Phe Glu Asn Asp Gly Glu Glu His Ile Met Thr 
        115                 120                 125             


Met Ala Glu Met Tyr Glu Arg Tyr Lys Asp Leu Gly Glu Phe Tyr Asp 
    130                 135                 140                 


Pro Glu Tyr Asn Arg Trp Gly Ile Asn Val Glu Glu Val Pro Val Tyr 
145                 150                 155                 160 


Val Lys Ser Phe Asp Pro Ser Thr Lys Glu Ile Thr Lys Gly Lys Val 
                165                 170                 175     


Lys Val Ile Trp Lys Tyr Glu Leu Gly Glu Asp Val Pro Lys Tyr Glu 
            180                 185                 190         


Ile Lys Thr Asn Lys Gly Thr Arg Val Leu Thr Ser Pro Trp His Pro 
        195                 200                 205             


Phe Phe Val Ile Thr Gln Asp Leu Lys Ile Val Glu Lys Arg Ala Asp 
    210                 215                 220                 


Glu Leu Arg Glu Gly Asp Met Leu Val Gly Gly Met Pro Ser Asp Asp 
225                 230                 235                 240 


Asp Tyr Glu Phe Leu Leu Asp Tyr Trp Leu Ala Gly Phe Ile Ala Gly 
                245                 250                 255     


Asp Gly Ser Ile Asp Lys Tyr Arg Ser His Val Lys Gly His Glu Tyr 
            260                 265                 270         


Val Tyr Asp Arg Leu Arg Ile Tyr Asp Tyr Thr Thr Glu Thr Leu Gly 
        275                 280                 285             


Ile Ile Asn Asp His Leu Glu Lys Thr Phe Gly Lys Arg Tyr Ser Leu 
    290                 295                 300                 


Gln Arg Asp Arg Asn Ile His Tyr Ile Asp Ile Lys Ala Lys Gly Ile 
305                 310                 315                 320 


Thr Ser His Tyr Ile Glu Leu Leu Arg Gly Ile Thr Asn Gly Ile Pro 
                325                 330                 335     


Gln Pro Ile Leu Lys Glu Gly Arg Asn Ala Val Leu Ser Phe Ile Thr 
            340                 345                 350         


Gly Leu Phe Asp Ala Glu Gly His Val Asn Ser Lys Pro Gly Val Glu 
        355                 360                 365             


Leu Gly Met Val Asn Arg Lys Leu Ile Glu Asp Ile Thr Tyr Tyr Leu 
    370                 375                 380                 


Asn Ser Leu Gly Ile Lys Ala Arg Met Arg Lys Lys Pro Arg Lys Asp 
385                 390                 395                 400 


Gly Val Asp Tyr Val Met His Val Glu Glu Tyr Ser Ser Leu Leu Arg 
                405                 410                 415     


Phe Tyr Glu Leu Ile Gly Lys Asn Leu Gln Asn Ser Glu Lys Arg Ile 
            420                 425                 430         


Lys Leu Glu Glu Leu Leu Ser Lys His Asn Gly Gly Ser Phe Gly Leu 
        435                 440                 445             


Thr Leu Ser Phe Glu Asp Phe Lys Ala Trp Ser Ser Lys Tyr Gly Val 
    450                 455                 460                 


Glu Phe Lys Thr Asn Gly Ser Gln Thr Leu Ala Ile Ile Lys Asn Glu 
465                 470                 475                 480 


Lys Val Ser Leu Gly Gln Trp His Arg Arg Gly Arg Val Ser Lys Ala 
                485                 490                 495     


Val Leu Val Lys Met Leu Arg Lys Leu Tyr Asp Thr Thr Lys Ser Glu 
            500                 505                 510         


Asp Val Lys Arg Met Leu His Leu Ile Glu Gly Leu Glu Val Val Lys 
        515                 520                 525             


Glu Ile Asn Val Thr Asn Glu Pro Lys Thr Phe Tyr Asp Leu Thr Val 
    530                 535                 540                 


Glu Arg Tyr Gln Asn Tyr Leu Ala Gly Glu Asn Gly Met Val Phe Val 
545                 550                 555                 560 


His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
                565                 570                 575     


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
            580                 585                 590         


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
        595                 600                 605             


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
    610                 615                 620                 


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
625                 630                 635                 640 


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
                645                 650                 655     


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
            660                 665                 670         


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
        675                 680                 685             


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
    690                 695                 700                 


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
705                 710                 715                 720 


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
                725                 730                 735     


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
            740                 745                 750         


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
        755                 760                 765             


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
    770                 775                 780                 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
785                 790                 795                 800 


Val Asn Ala Glu Ala Ala Thr Arg 
                805             


<210>  288
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tko_TopA

<400>  288

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu His Pro 
            100                 105                 110         


Asp Ser Leu Ile Pro Thr Pro Gln Gly Val Lys Arg Ile Lys Glu Leu 
        115                 120                 125             


Pro Glu Lys Gly Glu Val Phe Ala Leu Asp Phe Asp Leu Lys Leu Ser 
    130                 135                 140                 


Arg Ala Arg Tyr Arg Leu Leu Glu Arg Asp Ala Asp Glu Pro Met Tyr 
145                 150                 155                 160 


Lys Val Thr Leu Ser Asp Arg Thr Glu Leu Tyr Leu Thr Ala Asp His 
                165                 170                 175     


Pro Val Leu Val Tyr Arg Asp Asp Gln Leu Ile Phe Val Pro Ala Glu 
            180                 185                 190         


Glu Leu Arg Glu Asn Asp Gln Val Val Leu Phe Ile Asn Arg Ser Glu 
        195                 200                 205             


Tyr Ser Pro Arg Thr Glu Ser Pro Thr Leu Leu Gly Phe Leu Leu Glu 
    210                 215                 220                 


Asn Ala Thr Ser Met Lys Asp Tyr Ile Leu Tyr Asp Pro Glu Phe Gly 
225                 230                 235                 240 


Gly Val Leu Arg Asn Arg Ile Lys Asp Ala Gly Leu Lys Thr Glu Ile 
                245                 250                 255     


Leu Trp Arg Phe Arg Ile Arg Glu Pro Thr Tyr Tyr Lys Tyr Leu Arg 
            260                 265                 270         


Gly Lys Met Pro Val Pro Ile Val Arg Phe Leu Leu Glu Glu Gly Val 
        275                 280                 285             


Val Ser Ile Glu Glu Leu Arg Glu Val Phe Arg Gly Phe Ser Tyr Ser 
    290                 295                 300                 


Thr Ser Leu Thr Pro Ile Ser Phe Glu Phe Ser Glu Glu Phe Trp Tyr 
305                 310                 315                 320 


Leu Phe Gly Leu Val Ala Gly Asp Gly His Leu Ala Lys Lys Gly Ala 
                325                 330                 335     


Ile Thr Ile Pro Ala Lys Asp Arg Thr Glu Asp Thr Val Lys Ala Val 
            340                 345                 350         


Lys Glu Ile Ala Asn Ser Leu Gln Val Pro Phe Ala Phe Asp Glu Lys 
        355                 360                 365             


Tyr Lys Met Ile Ile Leu Arg Ser Lys Ser Leu Thr Arg Leu Phe Glu 
    370                 375                 380                 


Leu Leu Gly Cys Pro Tyr Gly Asn Lys Thr Glu Ile Phe Arg Ile Pro 
385                 390                 395                 400 


Gly Glu Ile Met Ala Lys Pro Glu Trp Met Ala Ala Phe Leu Ala Gly 
                405                 410                 415     


Tyr Tyr Asp Ala Asp Gly His Ile Gly Thr Lys Pro Thr Gly Gly Lys 
            420                 425                 430         


Lys Ser His Ser Pro Gln Ile Val Leu Thr Ser Lys Asn Arg Met Ala 
        435                 440                 445             


Ile Tyr Thr Val Lys Gln Met Trp Gln Leu Leu Gly Val Gly Thr Tyr 
    450                 455                 460                 


Leu Trp Glu Lys Lys Asp Arg Asn Gly Asn Phe Met Ala Tyr Glu Leu 
465                 470                 475                 480 


Lys Val Tyr Ser Arg Asp Ala Trp Arg Phe Tyr Glu Val Met Lys Asn 
                485                 490                 495     


His Leu Arg Ile Lys Arg Lys Asp Leu Glu His Val Lys Glu Val Ala 
            500                 505                 510         


Ile Arg Lys Arg Lys Ala Tyr Ser His His Tyr Ser Val Leu Asn Val 
        515                 520                 525             


Lys Ser Trp Glu Gly Lys Ile Lys Ser Ser Asn Val Leu Trp Lys Lys 
    530                 535                 540                 


Phe Asp Met Ser Asn Gln Thr Ala His Gly Arg Gly Ile Ser Leu Asp 
545                 550                 555                 560 


Lys Leu Gln Arg Ile Val Asp Tyr Leu Thr Asp Thr Asp Leu Arg Arg 
                565                 570                 575     


Ile Ala Met Gly Asp Val Tyr Val Leu Gly Ile Arg Ser Ile Glu Lys 
            580                 585                 590         


Phe His Tyr Arg Gly Lys Val Tyr Asp Leu Val Val Asp Gln Tyr His 
        595                 600                 605             


Asn Phe Ile Ala Asn Gly Val Val Val His Asn Ser Gly Val Lys Val 
    610                 615                 620                 


Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg 
625                 630                 635                 640 


Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn 
                645                 650                 655     


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser 
            660                 665                 670         


Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys 
        675                 680                 685             


Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly 
    690                 695                 700                 


Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu 
705                 710                 715                 720 


Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala 
                725                 730                 735     


Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala 
            740                 745                 750         


Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly 
        755                 760                 765             


Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala 
    770                 775                 780                 


Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro 
785                 790                 795                 800 


Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
                805                 810                 815     


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
            820                 825                 830         


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
        835                 840                 845             


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
    850                 855                 860                 


Arg 
865 


<210>  289
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Tth-HB27_DnaE-2

<400>  289

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Pro Ala 
            100                 105                 110         


Arg Ala Arg Val Val Asp Trp Cys Thr Gly Arg Val Val Arg Val Gly 
        115                 120                 125             


Glu Ile Val Arg Gly Glu Ala Lys Gly Val Trp Val Val Ser Leu Asp 
    130                 135                 140                 


Glu Ala Arg Leu Arg Leu Val Pro Arg Pro Val Val Ala Ala Phe Pro 
145                 150                 155                 160 


Ser Gly Lys Ala Gln Val Tyr Ala Leu Arg Thr Ala Thr Gly Arg Val 
                165                 170                 175     


Leu Glu Ala Thr Ala Asn His Pro Val Tyr Thr Pro Glu Gly Trp Arg 
            180                 185                 190         


Pro Leu Gly Thr Leu Ala Pro Gly Asp Tyr Val Ala Leu Pro Arg His 
        195                 200                 205             


Leu Ser Tyr Arg Pro Ser Leu His Leu Glu Gly His Glu Leu Asp Leu 
    210                 215                 220                 


Leu Gly Phe Ala Leu Ala Glu Gly His Leu Arg His Pro Ser Gly Val 
225                 230                 235                 240 


Tyr Leu Tyr Thr Ser Ser Glu Glu Glu Leu Ala Ala Met Glu Glu Ala 
                245                 250                 255     


Leu Arg Ala Phe Pro Asn Thr Arg Ile Arg Val Val Trp Arg Arg Gly 
            260                 265                 270         


Val Ala His Val Tyr Val Gly Arg Val Asp Arg Arg Gln Glu Ala Gly 
        275                 280                 285             


Ala Val Ala Phe Leu Arg Arg Met Gly Leu Leu Gly Leu Asp Ala Lys 
    290                 295                 300                 


Thr Lys Arg Leu Pro Glu Ala Val Phe Gly Leu Pro Pro Glu Glu Val 
305                 310                 315                 320 


Ala Arg Phe Leu Gly Arg Leu Trp Thr Gly Asp Gly Gly Val Asp Pro 
                325                 330                 335     


Lys Gly Arg Leu Ile His Tyr Ala Thr Ala Ser Lys Glu Leu Ala Trp 
            340                 345                 350         


Gly Val Gln His Leu Leu Leu Arg Leu Gly Leu Gln Ser Arg Leu Val 
        355                 360                 365             


Glu Lys Arg Phe Ser Gly Gly Tyr Lys Gly Tyr Ala Val Tyr Leu Leu 
    370                 375                 380                 


Gly Gly Leu Glu Ala Ala Arg Arg Phe Ala Glu Thr Val Gly Pro Tyr 
385                 390                 395                 400 


Leu Val Gly Lys Arg Arg Gln Asp Leu Glu Ala Leu Leu Ala Ser Trp 
                405                 410                 415     


Glu Lys Ala Gly Arg Ser Thr Gly Asp Val Leu Pro Leu Ala Phe Leu 
            420                 425                 430         


Glu Glu Val Arg Ala Ala Val Ala Glu Val Ala Gln Gly Gln Val Ala 
        435                 440                 445             


Asp Leu Leu Arg Glu Ala Gly Leu Ala Glu Gly Leu Leu Cys Leu Gly 
    450                 455                 460                 


Arg Gly Arg Arg Gly Leu Ser Arg Ala Thr Val Gly Arg Leu Ala Ala 
465                 470                 475                 480 


Leu Thr Gly Ser Leu Ala Leu Leu Arg Leu Ala Glu Ala Glu Val Tyr 
                485                 490                 495     


Trp Asp Arg Val Glu Ala Val Glu Pro Leu Gly Glu Glu Glu Val Phe 
            500                 505                 510         


Asp Leu Thr Val Glu Gly Thr His Thr Phe Val Ala Glu Asp Val Ile 
        515                 520                 525             


Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser 
    530                 535                 540                 


Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly 
545                 550                 555                 560 


Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly 
                565                 570                 575     


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro 
            580                 585                 590         


Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly 
        595                 600                 605             


Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly 
    610                 615                 620                 


Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr 
625                 630                 635                 640 


Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val 
                645                 650                 655     


Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg 
            660                 665                 670         


Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg 
        675                 680                 685             


Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly 
    690                 695                 700                 


Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn 
705                 710                 715                 720 


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
                725                 730                 735     


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
            740                 745                 750         


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
        755                 760                 765             


Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775         


<210>  290
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Tth-HB27_RIR1-1

<400>  290

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu His Pro 
            100                 105                 110         


Asp Thr Leu Val His Thr Asp Arg Gly Thr Leu Arg Leu Arg Glu Leu 
        115                 120                 125             


Val Asp Pro Phe Arg Arg Gly Trp Gln Pro His Thr Leu Ser Val Ala 
    130                 135                 140                 


Thr Asp Glu Gly Trp Arg Pro Ser Pro Glu Gly Tyr Asn Asn Gly Val 
145                 150                 155                 160 


Ala Pro Thr Leu Arg Val Val Leu Glu Asn Gly Leu Glu Val Gln Gly 
                165                 170                 175     


Thr Leu Asn His Lys Leu Lys Val Leu Arg Glu Asp Gly Thr Arg Glu 
            180                 185                 190         


Trp Val Glu Leu Gln Asp Leu Arg Pro Gly Asp Trp Val Ile Trp Val 
        195                 200                 205             


Leu Asp Glu His Thr Gly Thr Pro Val Gln Leu Ala Pro Leu Asp Glu 
    210                 215                 220                 


Pro Leu His Pro Asn Thr Thr Pro Ile Arg Thr Pro Glu Val Leu Thr 
225                 230                 235                 240 


Glu Asp Leu Ala Phe Leu Leu Gly Phe Phe Phe Gly Glu Gly Phe Val 
                245                 250                 255     


Ser Gly Asp Arg Ile Gly Phe Ser Val His Glu Glu Glu Pro Met Arg 
            260                 265                 270         


Glu Glu Ala Lys Arg Leu Phe Arg Glu Leu Phe Gly Leu Glu Leu Arg 
        275                 280                 285             


Glu Glu Arg Lys Pro Gly Asp Arg Ser Val Thr Leu Val Val Arg Ser 
    290                 295                 300                 


Arg Pro Leu Val Thr Trp Leu Arg Lys Asn Gly Leu Leu Lys Gly Lys 
305                 310                 315                 320 


Ala Arg Glu Leu Glu Val Pro Arg Ala Ile Arg Gln Ser Pro Arg Pro 
                325                 330                 335     


Val Leu Ala Ala Phe Leu Arg Gly Leu Phe Glu Ala Asp Gly Thr Ile 
            340                 345                 350         


Thr Ala Gly Tyr Pro Met Leu Thr Thr Ala Ser Lys Arg Leu Ala Gln 
        355                 360                 365             


Asp Val Met Val Leu Leu Gly Gly Leu Gly Ile Pro Ser Lys Leu Leu 
    370                 375                 380                 


Arg Tyr Asn Pro Leu Pro Gly Arg Phe Ser Lys Ala Glu His Tyr Gly 
385                 390                 395                 400 


Val Arg Val Val Thr Ala Lys Gly Leu Glu Arg Tyr Leu Glu Arg Ile 
                405                 410                 415     


Gly Val Pro Lys Gly Ser Arg Leu Glu Ala Leu His Gly Ile Lys Pro 
            420                 425                 430         


Asp Val Arg Arg Glu Ser Ser Trp Pro Leu Pro His Ala Glu Gly Leu 
        435                 440                 445             


Leu Lys Pro Leu Leu Thr Val Thr Glu Lys Gly Arg Lys Gly Tyr Ala 
    450                 455                 460                 


Ser Pro Tyr Thr Pro Leu Arg Lys Asp Leu Leu Arg Tyr Leu Arg Gly 
465                 470                 475                 480 


Glu Arg Gln Leu Thr Ala Thr Gly Tyr Ala Met Val Leu Glu Lys Ala 
                485                 490                 495     


Gln Asp Leu Gly Leu Glu Ala Glu Pro Phe Pro Phe Asn Glu Tyr Tyr 
            500                 505                 510         


Val Arg Val Ala Ser Val Glu Pro Gly Gly Glu Ile Leu Thr Leu Asp 
        515                 520                 525             


Leu Ser Val Glu Gly Asn His Thr Tyr Leu Ala Asn Gly Leu Val Ser 
    530                 535                 540                 


His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr 
545                 550                 555                 560 


His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu 
                565                 570                 575     


Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr 
            580                 585                 590         


Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser 
        595                 600                 605             


Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser 
    610                 615                 620                 


Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met 
625                 630                 635                 640 


His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu 
                645                 650                 655     


Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala 
            660                 665                 670         


Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr 
        675                 680                 685             


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
    690                 695                 700                 


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
705                 710                 715                 720 


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
                725                 730                 735     


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            740                 745                 750         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        755                 760                 765             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    770                 775                 780                 


Val Asn Ala Glu Ala Ala Thr Arg 
785                 790         


<210>  291
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Tth-HB27_RIR1-2

<400>  291

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Val Gly 
            100                 105                 110         


Ser Thr Arg Ile Pro Thr Glu Arg Gly Leu Val Pro Ile Glu Glu Leu 
        115                 120                 125             


Ala Arg Glu Gly Gly Ser Phe Tyr Leu Val Thr Asp Asn Arg Ala Pro 
    130                 135                 140                 


Phe Gly Gly Arg Gly Ala Pro Leu Pro Gly His Gly Thr Ala Val Arg 
145                 150                 155                 160 


Lys Ala Val Arg Ala Phe Phe Thr Gly Val Lys Pro Val Val Arg Leu 
                165                 170                 175     


Arg Thr Arg Glu Gly Leu Glu Val Thr Leu Thr Pro Asp His Leu Leu 
            180                 185                 190         


Leu Thr Pro Glu Gly Tyr Arg Glu Ala Gly Lys Leu Arg Pro Gly Glu 
        195                 200                 205             


Lys Ile Leu Val Gln Ser Gly Glu Gly Leu Phe Pro Lys Glu Glu Ser 
    210                 215                 220                 


Leu Pro Ala Gln Ala Leu Ala Val Val His Glu Arg Val Ala Thr Ala 
225                 230                 235                 240 


Gly Gly Arg Gly Gly Arg Gly Arg Ala Asp Val Arg Ala Gln Tyr Arg 
                245                 250                 255     


Asn Leu Pro Thr Arg Trp Ser Arg Glu Leu Gly Val Ala Leu Gly Trp 
            260                 265                 270         


Leu Leu Gly Asp Gly Tyr Leu Arg Glu Asp Gly Val Gly Phe Tyr Phe 
        275                 280                 285             


Ser Arg Lys Asp Phe Ala Asp Leu Ala Trp Leu Pro Asp Leu Leu Arg 
    290                 295                 300                 


Asp Trp Phe Gly Pro Gly Thr Leu Gln Glu Thr Arg Ser Asn Thr Phe 
305                 310                 315                 320 


His Leu His Phe Asn Arg Ile Pro Ala Glu Phe Phe Gln Ala Leu Gly 
                325                 330                 335     


Val Lys Ala Ala Arg Ala Thr Glu Lys Arg Val Pro Glu Ser Leu Phe 
            340                 345                 350         


Arg Ala Pro Arg Glu Ala Val Val Gly Phe Leu Gln Gly Leu Phe Ser 
        355                 360                 365             


Ala Asp Gly Ser Val Gln Ile Asn Glu Asn Lys Gln Asp Ala Thr Val 
    370                 375                 380                 


Arg Leu Ala Ser Ser Ser Leu Ala Leu Leu Gln Asp Val Gln Leu Leu 
385                 390                 395                 400 


Leu Leu Asn Leu Gly Ile Leu Gly Lys Ile His Lys Arg Arg Glu Ala 
                405                 410                 415     


Ala Arg Lys Ala Leu Pro Asp Gly Lys Gly Gly Leu Arg Glu Tyr Pro 
            420                 425                 430         


Val Ala Pro Gln Tyr Glu Leu Ile Leu Gly Gly Glu Asn Arg Asp Arg 
        435                 440                 445             


Phe Ala Glu Val Val Gly Phe Leu Gln Glu Glu Lys Gln Ser Lys Leu 
    450                 455                 460                 


Leu Ala Phe Leu Arg His Arg Pro Arg Gly Ser Tyr Arg Lys Pro Phe 
465                 470                 475                 480 


Leu Ala Thr Val Ala Ser Val Glu Pro Ala Gly Glu Ala Pro Val Tyr 
                485                 490                 495     


Asp Leu Thr Glu Pro Val Thr His Ser Leu Ile Ala Asn Gly Leu Val 
            500                 505                 510         


Ala His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser 
        515                 520                 525             


Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly 
    530                 535                 540                 


Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly 
545                 550                 555                 560 


Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro 
                565                 570                 575     


Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly 
            580                 585                 590         


Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly 
        595                 600                 605             


Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr 
    610                 615                 620                 


Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val 
625                 630                 635                 640 


Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg 
                645                 650                 655     


Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg 
            660                 665                 670         


Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly 
        675                 680                 685             


Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn 
    690                 695                 700                 


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
705                 710                 715                 720 


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
                725                 730                 735     


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
            740                 745                 750         


Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760     


<210>  292
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tvo_VMA

<400>  292

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Ser Gly 
            100                 105                 110         


Glu Thr Pro Val Tyr Leu Ala Asp Gly Lys Thr Ile Lys Ile Lys Asp 
        115                 120                 125             


Leu Tyr Ser Ser Glu Arg Lys Lys Glu Asp Asn Ile Val Glu Ala Gly 
    130                 135                 140                 


Ser Gly Glu Glu Ile Ile His Leu Lys Asp Pro Ile Gln Ile Tyr Ser 
145                 150                 155                 160 


Tyr Val Asp Gly Thr Ile Val Arg Ser Arg Ser Arg Leu Leu Tyr Lys 
                165                 170                 175     


Gly Lys Ser Ser Tyr Leu Val Arg Ile Glu Thr Ile Gly Gly Arg Ser 
            180                 185                 190         


Val Ser Val Thr Pro Val His Lys Leu Phe Val Leu Thr Glu Lys Gly 
        195                 200                 205             


Ile Glu Glu Val Met Ala Ser Asn Leu Lys Val Gly Asp Met Ile Ala 
    210                 215                 220                 


Ala Val Ala Glu Ser Glu Ser Glu Ala Arg Asp Cys Gly Met Ser Glu 
225                 230                 235                 240 


Glu Cys Val Met Glu Ala Glu Val Tyr Thr Ser Leu Glu Ala Thr Phe 
                245                 250                 255     


Asp Arg Val Lys Ser Ile Ala Tyr Glu Lys Gly Asp Phe Asp Val Tyr 
            260                 265                 270         


Asp Leu Ser Val Pro Glu Tyr Gly Arg Asn Phe Ile Gly Gly Glu Gly 
        275                 280                 285             


Leu Leu Val Leu His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    290                 295                 300                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
305                 310                 315                 320 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                325                 330                 335     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            340                 345                 350         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        355                 360                 365             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    370                 375                 380                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
385                 390                 395                 400 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                405                 410                 415     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            420                 425                 430         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        435                 440                 445             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    450                 455                 460                 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
465                 470                 475                 480 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
                485                 490                 495     


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
            500                 505                 510         


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
        515                 520                 525             


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    530                 535                 540 


<210>  293
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Tvu_DnaE-n_NC-terminal

<400>  293

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ser Gly 
            100                 105                 110         


Glu Thr Ala Val Met Thr Val Glu Tyr Gly Ala Ile Pro Ile Arg Arg 
        115                 120                 125             


Leu Val Gln Glu Arg Leu Ile Cys Gln Val Tyr Ser Leu Asp Pro Gln 
    130                 135                 140                 


Gly His Leu Tyr Thr Gln Pro Ile Ala Gln Trp His Phe Gln Gly Phe 
145                 150                 155                 160 


Arg Pro Val Tyr Ala Tyr Gln Leu Glu Asp Gly Ser Thr Ile Cys Ala 
                165                 170                 175     


Thr Pro Asp His Arg Phe Met Thr Thr Ser Gly Gln Met Leu Pro Ile 
            180                 185                 190         


Glu Gln Ile Phe Arg Glu Gly Leu Glu Leu Trp Gln Val Ala Ile Ala 
        195                 200                 205             


Pro Pro Gly Ala Leu Ala Gln Gly Leu Lys Pro Ala Val Gln Met Ser 
    210                 215                 220                 


Cys Met Lys Ile Val Gly Arg Arg Leu Val Gly Trp Gln Ala Val Tyr 
225                 230                 235                 240 


Asp Ile Gly Leu Ala Gly Asp His Asn Phe Leu Leu Ala Asn Gly Ala 
                245                 250                 255     


Ile Ala Ala Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
            260                 265                 270         


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
        275                 280                 285             


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
    290                 295                 300                 


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
305                 310                 315                 320 


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
                325                 330                 335     


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
            340                 345                 350         


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
        355                 360                 365             


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
    370                 375                 380                 


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
385                 390                 395                 400 


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
                405                 410                 415     


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
            420                 425                 430         


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
        435                 440                 445             


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
    450                 455                 460                 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
465                 470                 475                 480 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
                485                 490                 495     


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            500                 505     


<210>  294
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Unc-ERS_RIR1

<400>  294

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Val Thr Ala 
            100                 105                 110         


Asp Thr Trp Val Thr Thr Ala Glu Gly Pro Arg Gln Val Glu Glu Leu 
        115                 120                 125             


Ile Gly Lys Lys Phe Thr Ala Ile Val Asn Gly Glu Glu Trp Glu Ser 
    130                 135                 140                 


Ser Glu Glu Gly Phe Phe Glu Thr Asp Val Lys Pro Val Tyr Thr Leu 
145                 150                 155                 160 


Lys Thr Ala Glu Gly Phe Glu Leu Arg Leu Thr Ala Asp His Pro Val 
                165                 170                 175     


Met Lys Val Glu Arg Met Thr Arg Tyr Lys Val Glu Thr Gln Trp Ser 
            180                 185                 190         


Asn Ala Gly Asp Leu Lys Pro Gly Asp Lys Ile Ile Ile Asn Asn His 
        195                 200                 205             


Arg Asp Phe Gly Asn Trp Ser Val Lys Gly Lys Tyr Thr Glu Gly Glu 
    210                 215                 220                 


Gly Tyr Leu Ile Gly Leu Leu Leu Gly Asp Gly Thr Ile Lys Lys Leu 
225                 230                 235                 240 


Asn Pro Trp Met Lys Ala Ile Ser Lys Lys Met Glu Lys Ala Ser Ala 
                245                 250                 255     


Asp Phe Cys Glu Gly Ile Leu Arg Gly Leu Phe Asp Ala Asp Gly Ser 
            260                 265                 270         


Val Gln Gly Asn Gln Ser Lys Gly Val Ser Ile Arg Leu Ala Gln Ser 
        275                 280                 285             


Asp Val Glu Ile Leu Lys Ala Val Gln Arg Ile Leu Leu Arg Phe Gly 
    290                 295                 300                 


Ile Phe Ser Lys Val Tyr Met Asn Arg Arg Gly Glu Arg Lys Val Lys 
305                 310                 315                 320 


Met Pro Asp Gly Lys Gly Gly Val Lys Glu Tyr Ile Thr Lys Pro Gln 
                325                 330                 335     


His Glu Leu Val Ile Ser Asn Asp Asn Ile Leu Tyr Phe Ala Glu Arg 
            340                 345                 350         


Val Gly Phe Ser Asp Ala Glu Lys Met Glu Lys Leu Glu Lys Ala Ile 
        355                 360                 365             


Trp Asn Tyr Lys Arg Lys Met Asn Arg Glu Arg Phe Val Ala Ser Val 
    370                 375                 380                 


Glu Glu Val Val Pro Asp Gly Val Glu Lys Val Tyr Asp Val Lys Ile 
385                 390                 395                 400 


Pro Gly Ile Asn Ala Phe Asn Ala Asn Gly Phe Val Val His Asn Ser 
                405                 410                 415     


Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp 
            420                 425                 430         


Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr 
        435                 440                 445             


Gln Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala 
    450                 455                 460                 


Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu 
465                 470                 475                 480 


Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser 
                485                 490                 495     


Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala 
            500                 505                 510         


Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala 
        515                 520                 525             


Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly 
    530                 535                 540                 


Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
545                 550                 555                 560 


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
                565                 570                 575     


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
            580                 585                 590         


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
        595                 600                 605             


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
    610                 615                 620                 


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
625                 630                 635                 640 


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
                645                 650                 655     


Glu Ala Ala Thr Arg 
            660     


<210>  295
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Zba_VMA

<400>  295

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Lys 
            100                 105                 110         


Gly Thr Glu Val Met Met His Asp Gly Ser Val Lys Ala Ile Glu Thr 
        115                 120                 125             


Ile Glu Ala Gly Glu Ala Val Met Gly Thr Asp Gly Gln Pro Arg Lys 
    130                 135                 140                 


Val Val Gly Leu Pro Arg Gly Arg Glu Val Met Tyr Lys Val Ser Gln 
145                 150                 155                 160 


Lys Thr Ala His Arg Val His Lys Thr Asp Glu Thr Arg Ala Ala Pro 
                165                 170                 175     


Val Ala Leu Phe Glu Tyr Asn Cys Asn Ala Thr His Lys Leu Val Val 
            180                 185                 190         


Arg Thr Pro Arg Ser Cys Arg Ser Ile Thr Arg Lys Met Gln Gly Val 
        195                 200                 205             


Asp Tyr Asn Glu Val Ile Phe Phe Asp Leu Lys Lys Lys Lys Leu Glu 
    210                 215                 220                 


Asp Gly Arg Glu Ile Glu Ile Val Lys Glu Val Ser Arg Ser Tyr Pro 
225                 230                 235                 240 


Ala Ala Glu Gly Ala Glu Lys Ala Ala Gln Met Val Lys Asp Tyr Tyr 
                245                 250                 255     


Asp Ala Ala Arg Gly Lys Glu Phe Phe Glu Trp Thr Ile Glu Ala Arg 
            260                 265                 270         


Asp Val Arg Glu Leu Gly Ala His Val Arg Lys Ala Thr His Gln Val 
        275                 280                 285             


Tyr Ala Pro Val Leu Tyr Glu Ser Asp Phe Phe Phe His Tyr Val Lys 
    290                 295                 300                 


Asn Ser Lys Phe Ala Leu Arg Ser Glu Ala Ser Thr Ala Leu Ala Tyr 
305                 310                 315                 320 


Leu Leu Gly Leu Trp Val Gly Asp Gly Leu Ser Asp Arg Ala Val Leu 
                325                 330                 335     


Ser Val Asp Ser Glu Asp Ser Ser Leu Leu Glu Arg Ile Thr Gly Tyr 
            340                 345                 350         


Ala Asp Ile Leu Asp Leu Ser Ala Glu Tyr Lys Asp Arg Glu Ile Pro 
        355                 360                 365             


Lys Arg Ala Lys Thr Val Cys Leu Tyr Pro Lys Thr Ile Arg Gly Asn 
    370                 375                 380                 


Asp Ile Arg Arg Asn Leu Asn Thr Asp Asn Pro Val Trp Asn Ala Ile 
385                 390                 395                 400 


Val Asp Leu Gly Tyr Leu Lys Asp Gly Val Lys Asn Val Pro Ser Tyr 
                405                 410                 415     


Leu Phe Ser Asp Ser Ile Cys His Arg Glu Val Phe Leu Ala Gly Leu 
            420                 425                 430         


Ile Asp Ser Asp Gly His Val Arg Gly Asp Asp Gly Leu Ser Val Thr 
        435                 440                 445             


Ile Lys Thr Ile His Lys Thr Val Met Glu Gly Thr Val Ala Val Ala 
    450                 455                 460                 


Arg Ser Leu Gly Leu Ile Val Ser Val Asn Thr Glu Glu Ala Lys Ile 
465                 470                 475                 480 


Asp Lys Asn Asp Val Asn His Arg Phe Val Tyr Ala Ile Tyr Ile Ser 
                485                 490                 495     


Gly Gly Asp Ala Leu Leu Ser Val Leu Ala His Cys Ala Ala Ala Lys 
            500                 505                 510         


Lys Phe Arg Ala Pro Pro Ser Asn Glu Val Val Arg Gly Leu Lys Lys 
        515                 520                 525             


Val Phe Phe Glu Met Glu Glu Leu Lys Glu Asp Asp Tyr Tyr Gly Ile 
    530                 535                 540                 


Thr Leu Ala Lys Glu Ser Asp His Gln Phe Leu Leu Ala Asn Gln Leu 
545                 550                 555                 560 


Val Val His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly Ile 
                565                 570                 575     


Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val Pro 
            580                 585                 590         


Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val Ala 
        595                 600                 605             


Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val Ala 
    610                 615                 620                 


Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly Ser 
625                 630                 635                 640 


Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn 
                645                 650                 655     


Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala 
            660                 665                 670         


Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu Val 
        675                 680                 685             


Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala 
    690                 695                 700                 


Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn 
705                 710                 715                 720 


Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro 
                725                 730                 735     


Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu 
            740                 745                 750         


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
        755                 760                 765             


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
    770                 775                 780                 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
785                 790                 795                 800 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                805                 810 


<210>  296
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Zro_VMA

<400>  296

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Ala Lys 
            100                 105                 110         


Gly Thr Glu Val Met Met Ser Asp Gly Ser Ile Lys Glu Val Glu Gly 
        115                 120                 125             


Ile Glu Val Gly Gln Glu Val Met Gly Lys Asp Gly Lys Pro Arg Glu 
    130                 135                 140                 


Val Val Gly Thr Pro Ser Gly Arg Glu Lys Met Tyr Lys Val Ser His 
145                 150                 155                 160 


Lys Thr Ala His Arg Ala His Lys Ser Asp Ser Thr Ser Glu Arg Phe 
                165                 170                 175     


Gly Leu Phe Glu Tyr Thr Cys Asn Ala Thr His Lys Leu Val Val Arg 
            180                 185                 190         


Thr Ser Arg Ser Cys Arg Pro Leu Val Arg Asn Ile Gln Gly Thr Asp 
        195                 200                 205             


Tyr Val Glu Val Cys Leu Phe Asn Met Thr Lys Lys Thr Leu Glu Asp 
    210                 215                 220                 


Gly Arg Val Ile Asp Ile Val Glu Glu Thr Ser Asp Phe Tyr Pro Ala 
225                 230                 235                 240 


Val Glu Gly Pro Glu Lys Ala Leu Arg Ile Leu Lys Glu Tyr Ala Glu 
                245                 250                 255     


Ala Asp Gly Gly Lys Glu Tyr Phe Glu Trp Thr Ile Glu Ala Arg Asp 
            260                 265                 270         


Val Ala Leu Leu Ser Ala Gln Val Arg Lys Ala Thr Tyr Gln Leu Ser 
        275                 280                 285             


Ala Pro Val Leu Leu Glu Asn Asn His Phe Ser His Tyr Leu Lys Asp 
    290                 295                 300                 


Ser Asn Ser Ala Val Gly Asn Asp Thr Val Arg Ala Leu Ser Tyr Phe 
305                 310                 315                 320 


Leu Gly Leu Trp Ile Gly Asp Gly Met Leu Asn Asn Ala Ala Thr Phe 
                325                 330                 335     


Ser Val Asp Ser Gln Asn Ala Ser Leu Leu Asn Arg Ile Asn Glu Phe 
            340                 345                 350         


Ala Glu Val Leu Gly Leu Ser Ala Glu Tyr Lys Asp Ser Gln Glu Pro 
        355                 360                 365             


Lys Arg Ala Lys Thr Val Asn Leu Tyr Ala Lys Ala Ile Arg Asp Glu 
    370                 375                 380                 


Gly Val Arg Lys Asn Leu Asp Thr His Asn Leu Leu Trp Asp Ala Ile 
385                 390                 395                 400 


Val Asp Leu Gly Tyr Leu Lys Asp Asp Ser Lys Asn Val Pro Gly Tyr 
                405                 410                 415     


Ile Cys Ser Asp Ser Phe Gln His Arg Glu Val Phe Leu Ala Gly Ile 
            420                 425                 430         


Ile Asp Ser Thr Gly Tyr Val Ser Asp Glu Thr Ala Thr Val Lys Thr 
        435                 440                 445             


Ile Asp Gln Ser Val Met Thr Gly Thr Val Ala Val Ala Arg Ser Leu 
    450                 455                 460                 


Gly Ile Asn Val Ser Val Asp Val Glu Val Asp Glu Asp Gly Val Asp 
465                 470                 475                 480 


Arg Ser Phe Val Tyr Ala Ile Tyr Met Asp Arg Ser Asp Ala Leu Leu 
                485                 490                 495     


Ala Val Leu Ala Asn Cys Ala Ser Asn Asn Lys Gln Ile Glu Ala Pro 
            500                 505                 510         


Pro His Gly Val Ile Arg Glu Phe Asn Lys Ala Tyr Phe Glu Met Glu 
        515                 520                 525             


Glu Leu Glu Glu Asp Glu Tyr Tyr Gly Leu Thr Leu Ser Asn Glu Ser 
    530                 535                 540                 


Asp His Gln Phe Leu Leu Ala Asn Gln Leu Val Val His Asn Ser Gly 
545                 550                 555                 560 


Val Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu 
                565                 570                 575     


Asn Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln 
            580                 585                 590         


Asp Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu 
        595                 600                 605             


Asn Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr 
    610                 615                 620                 


Ala Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile 
625                 630                 635                 640 


Ala Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn 
                645                 650                 655     


Leu Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val 
            660                 665                 670         


Asn Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn 
        675                 680                 685             


Ser Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met 
    690                 695                 700                 


Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln 
705                 710                 715                 720 


Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser 
                725                 730                 735     


Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
            740                 745                 750         


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
        755                 760                 765             


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
    770                 775                 780                 


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
785                 790                 795                 800 


Ala Ala Thr Arg 
                


<210>  297
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Aae_RIR2

<400>  297

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ile Glu Gly Thr Glu Val Leu Thr Lys Arg Gly Phe 
    290                 295                 300                 


Val Asp Phe Arg Glu Leu Arg Glu Asp Asp Leu Val Ala Gln Tyr Asp 
305                 310                 315                 320 


Ile Glu Thr Gly Glu Ile Ser Trp Thr Lys Pro Tyr Ala Tyr Val Glu 
                325                 330                 335     


Arg Asp Tyr Glu Gly Ser Met Tyr Arg Leu Lys His Pro Lys Ser Asn 
            340                 345                 350         


Trp Glu Val Val Ala Thr Glu Gly His Glu Phe Ile Val Arg Asn Leu 
        355                 360                 365             


Lys Thr Gly Lys Glu Arg Lys Glu Pro Ile Glu Lys Val Lys Leu His 
    370                 375                 380                 


Pro Tyr Ser Ala Ile Pro Val Ala Gly Arg Tyr Thr Gly Glu Val Glu 
385                 390                 395                 400 


Glu Tyr Asp Leu Trp Glu Leu Val Ser Gly Lys Gly Ile Thr Leu Lys 
                405                 410                 415     


Thr Arg Ser Ala Val Lys Asn Lys Leu Thr Pro Ile Glu Lys Leu Leu 
            420                 425                 430         


Ile Val Leu Gln Ala Asp Gly Thr Ile Asp Ser Lys Arg Asn Gly Lys 
        435                 440                 445             


Phe Thr Gly Phe Gln Gln Leu Lys Phe Phe Phe Ser Lys Tyr Arg Lys 
    450                 455                 460                 


Ile Asn Glu Phe Glu Lys Ile Leu Asn Glu Cys Ala Pro Tyr Gly Ile 
465                 470                 475                 480 


Lys Trp Lys Lys Tyr Glu Arg Gln Asp Gly Ile Ala Tyr Thr Val Tyr 
                485                 490                 495     


Tyr Pro Asn Asp Leu Pro Ile Lys Pro Thr Lys Phe Phe Asp Glu Trp 
            500                 505                 510         


Val Arg Leu Asp Glu Ile Thr Glu Glu Trp Ile Arg Glu Phe Val Glu 
        515                 520                 525             


Glu Leu Val Lys Trp Asp Gly His Ile Pro Lys Asp Arg Asn Lys Lys 
    530                 535                 540                 


Lys Val Tyr Tyr Tyr Ser Thr Lys Glu Lys Arg Asn Lys Asp Phe Val 
545                 550                 555                 560 


Gln Ala Leu Cys Ala Leu Gly Gly Met Arg Thr Val Val Ser Arg Glu 
                565                 570                 575     


Arg Asn Pro Lys Ala Lys Asn Pro Val Tyr Arg Ile Trp Ile Tyr Leu 
            580                 585                 590         


Glu Asp Asp Tyr Ile Asn Thr Gln Thr Met Val Lys Glu Glu Phe Tyr 
        595                 600                 605             


Tyr Lys Gly Lys Val Tyr Cys Val Ser Val Pro Lys Gly Asn Ile Val 
    610                 615                 620                 


Val Arg Tyr Lys Asp Ser Val Cys Ile Ala Gly Asn Ser Thr Tyr Ala 
625                 630                 635                 640 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
                645                 650                 655     


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
            660                 665                 670         


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
        675                 680                 685             


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695                 700 


<210>  298
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ace_RIR1

<400>  298

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Gln Pro Tyr Ser Ala Pro Val Ser Thr Pro Asp Gly Pro 
    290                 295                 300                 


Ile Pro Ile Gly Lys Leu Val Asp Ala Asn Ala Val Gly Glu Lys Val 
305                 310                 315                 320 


Phe Asp Ala Ser Gly Val Thr Arg Ile Val Ala Thr Thr Cys Asn Gly 
                325                 330                 335     


Arg Lys Pro Val Leu Arg Ile Arg Thr Ser Gly Gly His Val Leu Asp 
            340                 345                 350         


Val Thr Pro Asp His Leu Val Trp Gln Val Val Asp Gln Thr Ala Gly 
        355                 360                 365             


Arg Phe Val Pro Ala Gly Gln Leu Arg Val Gly Asp Arg Leu Glu Trp 
    370                 375                 380                 


His Asp Arg Ala Asn Ser Asp Ala Met Val Ala Ala Phe Thr Ala Asp 
385                 390                 395                 400 


Ser Ala Ala Ala Ala Gln Pro Gly Gln Ile Val Asp Ile Leu Ala Ile 
                405                 410                 415     


Asp Glu Leu Gly Val Met Pro Val Tyr Asp Ile Gln Thr Glu Ser Gly 
            420                 425                 430         


Glu Tyr Leu Ser Asp Gly Ile Arg Val His Asn Ser Thr Tyr Ala Ser 
        435                 440                 445             


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
    450                 455                 460                 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
465                 470                 475                 480 


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
                485                 490                 495     


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            500                 505         


<210>  299
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Aeh_DnaB-2

<400>  299

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Gly Asp Thr Arg Val Leu Leu Ala Asp Gly Gln 
    290                 295                 300                 


Arg Val Pro Ile Arg Asp Leu Val Gly Gln Thr Pro Glu Val Ile Ser 
305                 310                 315                 320 


Val Asn Ala Glu Gly Arg Leu Glu Pro Ala Lys Thr Asp Leu Val Trp 
                325                 330                 335     


Ser Val Gly Val Arg Pro Leu Leu Gln Val Arg Leu Ala Ser Gly Arg 
            340                 345                 350         


Thr Ile Arg Cys Thr Pro Glu His Arg Leu Arg Gly Leu Trp Asp Trp 
        355                 360                 365             


Lys Glu Ala Arg Asp Ile Arg Val Gly Asp Arg Leu Gly Ile Ala Arg 
    370                 375                 380                 


Glu Leu Pro Ala Pro Lys Val Thr Lys Arg Trp Ala Glu His Glu Leu 
385                 390                 395                 400 


Val Leu Leu Ala His Leu Val Gly Asp Gly Ser Tyr Ile Lys Gly Gln 
                405                 410                 415     


Pro Leu Arg Tyr Thr Thr Ala Ser Glu Ala Asn Ser Glu Ala Val Ser 
            420                 425                 430         


Arg Ala Ala Glu Ala Met Gly Ser Thr Val Thr Arg His Pro Gly Arg 
        435                 440                 445             


Gly Gln Trp His Gln Leu Val Ile Ser Gly Asn Gly Asn Arg Trp His 
    450                 455                 460                 


Pro Gln Gly Val Gly Lys Trp Leu Lys Gln Leu Gly Val Phe Gly Gln 
465                 470                 475                 480 


Arg Ser Arg Glu Lys His Leu Pro Gln Glu Val Phe Gln Leu Asp Asn 
                485                 490                 495     


Asp Gln Leu Ala Leu Phe Leu Arg His Leu Trp Ala Thr Asp Gly Ser 
            500                 505                 510         


Ile Thr Gln Gly Ser Ala Gly Arg Pro Arg Ile Tyr Phe Ser Thr Ala 
        515                 520                 525             


Ser Arg His Leu Ile Gln Asp Val Ala Ala Leu Leu Leu Arg Phe Gly 
    530                 535                 540                 


Ile Val Gly Arg Thr Lys His Ile Thr His Gly Asp Gly Glu Gly Trp 
545                 550                 555                 560 


Phe Thr Leu Asp Ile Ser Gly Ala Val Gln Gln Gln Arg Tyr Leu Glu 
                565                 570                 575     


Lys Ile Gly Ala Phe Gly His Gln Ala His Asn Ala Arg Arg Ala Leu 
            580                 585                 590         


Gln His Leu Arg Gly Leu Val Glu Asn Thr Asn Val Asp Thr Leu Pro 
        595                 600                 605             


Glu Glu Val Phe Asn Tyr Ile Arg Glu Arg Met Arg Glu Glu Gly Ile 
    610                 615                 620                 


Thr His Arg Gln Met Ala Ala Leu Arg Gly Thr Ala Tyr Gly Gly Ser 
625                 630                 635                 640 


Ala His Phe Thr Phe Ser Pro Ser Arg Glu Thr Leu Leu Ser Tyr Ala 
                645                 650                 655     


Asp Ile Leu Asn Asp Gln Arg Leu Arg Met Leu Ala Asn Gln His Val 
            660                 665                 670         


Phe Trp Asp Arg Val Val Ser Val Glu Pro Ala Gly Glu Glu Glu Val 
        675                 680                 685             


Phe Asp Leu Thr Val Pro Gly Asn Ala Cys Trp Leu Ala Asp Gly Ile 
    690                 695                 700                 


Val Ser His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
705                 710                 715                 720 


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
                725                 730                 735     


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
            740                 745                 750         


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
        755                 760                 765             


Ala Ala Thr Arg 
    770         


<210>  300
<211>  959
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Ani-FGSCA4_PRP8

<400>  300

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ala Asn Gly Thr Gln Leu Leu Arg Tyr Asp Gly Thr 
    290                 295                 300                 


Lys Val Asn Val Glu Asp Val Lys Glu Gly Asp Leu Leu Leu Gly Pro 
305                 310                 315                 320 


Asp Gly Gly Pro Arg Arg Ala Phe Asn Val Val Ser Gly Lys Asp Arg 
                325                 330                 335     


Leu Tyr Arg Ile Lys Ile Asp Gly Asp Lys Glu Asp Leu Val Val Thr 
            340                 345                 350         


Ala Asn His Ile Leu Val Leu His Arg Ala Lys Ala Met Asn Thr Ser 
        355                 360                 365             


Val Cys Phe Asp Arg Ser Lys Glu Gln Gln Gly Gly Ala Gly Glu Gln 
    370                 375                 380                 


Leu Asp Ile Ser Glu Val Ser Ala Ala Glu Arg Tyr Asp Thr Val Glu 
385                 390                 395                 400 


Met Thr Ala Ala Glu Phe Ala Ala Leu His Pro Gln Glu Arg Ser Trp 
                405                 410                 415     


Tyr Arg Ala Ile Arg Cys Pro Gly Phe Glu Leu Pro Glu Gln Asp Val 
            420                 425                 430         


Pro Val Asn Pro Tyr Phe Leu Gly Leu Trp Leu Gly Asp Glu Ser Arg 
        435                 440                 445             


Asn Gln Ser Ala Ile Tyr Ser Asn His Glu Glu Ala Leu Arg Glu Phe 
    450                 455                 460                 


Leu Val Ser His Ala Ala Glu Leu Asp Met His Leu Val Tyr His Gly 
465                 470                 475                 480 


Gln Ser Ala Tyr Ser Thr Val Cys Asn Lys Asp Arg Pro Thr Asn Lys 
                485                 490                 495     


Arg Ile Gly Pro Ala Asn Gln Thr Gln Thr Val Arg Pro Thr Ile Arg 
            500                 505                 510         


Gln Thr Arg Arg Thr Ile Arg Gln Gln Arg Leu Ala Ala Glu His Ala 
        515                 520                 525             


Ala Ala Glu Tyr Thr Thr Gln Arg Glu Thr Ala Ser Leu Thr Pro Leu 
    530                 535                 540                 


Leu Glu Ser Pro Thr Ser Asp Lys His Gly Leu Leu Ser Ser Val Glu 
545                 550                 555                 560 


Thr Pro Gly Arg Leu Ser Asp Ser Val Thr Thr Glu Leu Pro Met Ser 
                565                 570                 575     


Arg Ser Ala Ser Ala Met Arg Ser Ile Arg Thr Ala Ser Gly Leu Ser 
            580                 585                 590         


Glu Phe Asn Asp Val Thr Asn Val Ser Ala Ser Met Pro Asp Ile Gln 
        595                 600                 605             


Asn Ser Gly Ile Lys Asn Gln Gly Arg Ile Ala Lys Val Thr Arg Gln 
    610                 615                 620                 


Gln Asp Ser Lys Gly Glu Val Asp Phe Arg Gln Gln Tyr Ser Gln Ala 
625                 630                 635                 640 


Ile Lys Asp Asp Leu Glu Leu Leu Glu Thr Asp Ile Glu Asp Asp Val 
                645                 650                 655     


Ala Ser Ser Asp Glu Ile Glu Asp Val Cys Val Val Gly Ser Glu Asn 
            660                 665                 670         


Glu Leu Ile Gly Ser Glu Lys Gln Asp Gln Ser Gly Arg Arg Arg Gln 
        675                 680                 685             


Ile His Arg Leu Arg Thr Gly His Arg Gly Tyr Gly Asp Leu Ser Asp 
    690                 695                 700                 


Asp Glu Gln Glu Gln Leu Leu Asp Ser Val Val Glu Arg Tyr Ala Gly 
705                 710                 715                 720 


Asp Ser Arg Leu Asn Thr Leu Gln Gln Glu Leu Ser Lys Met Gly Ile 
                725                 730                 735     


Leu Asn Pro Glu Thr Gly Pro Ile Asn Asp Lys Lys Arg Ile Pro Gln 
            740                 745                 750         


Val Phe Met Gln Asn Ser Arg Ser Val Arg Leu Ser Val Leu Ala Gly 
        755                 760                 765             


Leu Leu Asp Ser Asp Gly Trp Tyr Ile Tyr Pro Glu Asn Met Phe Gly 
    770                 775                 780                 


Phe Ala Gln Ser Glu Leu Cys His Lys Glu Leu Phe Trp Asp Val Val 
785                 790                 795                 800 


Thr Leu Ala Arg Ser Leu Gly Phe Gly Val Trp Thr Lys Lys Arg Met 
                805                 810                 815     


Met Pro Asp Pro Thr Gly Lys Arg Met Ser Pro Met Leu Val Ala Gln 
            820                 825                 830         


Ile Ser Gly Asp Leu Ala Glu Ile Pro Cys Val Leu Ala Arg Lys Lys 
        835                 840                 845             


Ala Met Pro Arg Leu Ile Pro Gln Ser His Ser Phe Ala Ile Lys Asp 
    850                 855                 860                 


Ile Ser Leu Glu Ser Glu Ala Thr Glu Trp Ala Gly Phe Arg Val Asp 
865                 870                 875                 880 


Lys Asp Gln Leu Tyr Leu Arg His Asp Tyr Val Val Leu His Asn Ser 
                885                 890                 895     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            900                 905                 910         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        915                 920                 925             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    930                 935                 940                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
945                 950                 955                 


<210>  301
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ape_APE0745

<400>  301

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Leu Pro Pro Trp Glu Pro Ile Val Val Arg Arg Gly Asp 
    290                 295                 300                 


Glu Val Arg Val Thr Ser Ile Gly Glu Phe Val Asp Ser Phe Leu Glu 
305                 310                 315                 320 


Gly Glu Gly Gly Leu Asp Ile Gly Gly Leu Gly Tyr Tyr Thr Leu Ser 
                325                 330                 335     


Leu Asp Thr Arg Thr Leu Lys Pro Val Trp Arg Arg Ile Arg Gly Val 
            340                 345                 350         


Ile Lys His Arg Ile Arg Gly Arg Leu Leu Arg Val Lys Ala Ser Lys 
        355                 360                 365             


Gly Arg Ser Ile Asp Leu Thr Gly Ser His Ser Ile Tyr Arg Ile Ser 
    370                 375                 380                 


Arg Gly Gly Gly Leu Glu Val Val Gly Ser Ser Asp Leu Arg Pro Gly 
385                 390                 395                 400 


Asp Ser Leu Val Thr Pro Ala Ser Val Glu Leu Pro Glu Ser Ala Pro 
                405                 410                 415     


Ser Ser Ile Asn Ala Ala Arg Glu Leu Trp Ser Arg Gly Val Glu Gly 
            420                 425                 430         


Ile Phe Val Val Gly Leu Pro Gly Glu Ala Ala Gly Tyr Arg Gly Val 
        435                 440                 445             


Glu Arg Ser Arg Gly Tyr Asp Gly Gly His Ala Ile Pro Leu Glu Thr 
    450                 455                 460                 


Leu Val Glu Arg Tyr Gly Asp Ser Val Trp Ser Leu Val Ser Gly Ala 
465                 470                 475                 480 


Lys Leu Ala Val Ser Arg Gly Ala Ala Gly Asp His Pro Val Pro Ala 
                485                 490                 495     


Thr Ile Pro Leu Asp Thr Gly Phe Tyr Leu Leu Leu Gly Phe Ile Val 
            500                 505                 510         


Ser Ala Gly Ser Val Asp Val Glu Gly Gly His Val Thr Val Thr Leu 
        515                 520                 525             


Gly Pro Gly Arg Glu Gly Tyr Val Gly Asp Val Val Glu Ala Val Asn 
    530                 535                 540                 


Ser Thr Ala Pro Gly Ala Gly Val Arg Ile Ser Ser Gly Ala Arg Gly 
545                 550                 555                 560 


Met Glu Val Thr Ile Arg Ser Arg Val Leu Ser Glu Leu Leu Ala Arg 
                565                 570                 575     


Val Phe Gly Ala Gly Pro Gly Pro Asn Arg Asp Ile Pro Ser Ile Val 
            580                 585                 590         


Phe Arg Ala Pro Lys Pro Met Lys Arg Val Phe Leu Lys Gly Leu Tyr 
        595                 600                 605             


Ala Gly Gly Gly Val Phe Asp Arg Ser Ser Gly Ser Leu Ile Tyr Ala 
    610                 615                 620                 


Thr Asp Ser Arg Ser Leu Leu Asn Gly Leu Ala Leu Leu Leu Leu Asn 
625                 630                 635                 640 


Val Gly Ala Gly Gly Tyr Arg Ile Asp Ser Gly Asp Ser Gly Arg Ala 
                645                 650                 655     


Leu Ala Leu Ile Val Glu Asn Ala Gly Arg Leu Asp Ala Ile Gly Glu 
            660                 665                 670         


Val Leu Glu His Leu Gly Phe His Gly Gly Arg Glu Ala Val Gln Gly 
        675                 680                 685             


Val Gly Ala Leu Glu Arg Ala Thr Ala Gly Leu Ala Gly Gln Ala Thr 
    690                 695                 700                 


Val Ala Val Gln Arg Pro Ala Thr Arg Gly Gly Pro Gly Val Asp Val 
705                 710                 715                 720 


Ala Gly Val Thr Gly Leu Glu His Leu Glu Ala Ser Thr Glu Phe Val 
                725                 730                 735     


Tyr Asp Leu Ser Val Glu Gly Asp Glu Asn Phe Phe Ala Gly Leu Gly 
            740                 745                 750         


Trp Ile Leu Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
        755                 760                 765             


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
    770                 775                 780                 


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
785                 790                 795                 800 


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
                805                 810                 815     


Ala Glu Ala Ala Thr Arg 
            820         


<210>  302
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Avin_RIR1_BIL

<400>  302

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Pro Glu Thr Leu Val His Thr Ala Asp Gly Pro 
    290                 295                 300                 


Arg Pro Ile Arg Asp Leu Gln Gln Gly Asp Leu Val Leu Gly Ile Ser 
305                 310                 315                 320 


Gly Arg Tyr Arg Glu Val Thr His Lys Phe Val Tyr Asn Gln Thr Asp 
                325                 330                 335     


Ala Met Leu Ala Ile Arg Val Lys His Ala Val Glu Pro Ile Glu Val 
            340                 345                 350         


Thr Ala Gly His Pro Phe Tyr Ala Ile Arg Gly Val Pro Leu Glu Gln 
        355                 360                 365             


Ser Gly Glu Arg Thr Leu Arg Gln Leu Glu Ser Gly Lys Arg Ser Pro 
    370                 375                 380                 


Glu Trp Ile Asp Ala Gly Glu Leu Glu Arg Gly Asp Tyr Met Ala Gln 
385                 390                 395                 400 


Val Ile Pro Ser Glu Val Val Pro Val Ala Gly Phe Asp Glu Asp Asp 
                405                 410                 415     


Ala Arg Leu Tyr Gly Ile Leu Leu Gly Asp Gly His Leu Ser Lys Asn 
            420                 425                 430         


Gly Leu Gln Trp Gly Val Ser Gly His Pro Gln Arg Asp Gly His Met 
        435                 440                 445             


Asp Phe Val Arg Ala Tyr Leu Ser Ala Arg Gly Ile His Phe Trp Glu 
    450                 455                 460                 


Thr Ala Arg Asp Glu Thr Tyr Gly Gln Ile His Trp Ala Ser Gly Arg 
465                 470                 475                 480 


Gly Val Arg Arg Asp Ala Thr Thr Gly Arg Ile Thr Gly Ala Gly Ala 
                485                 490                 495     


Ala Thr Leu Pro Phe Glu His Ala Asp Leu Tyr Asp Glu Gln Gly Arg 
            500                 505                 510         


Lys Arg Ile Ala Arg Arg Phe Ser His Leu Pro Arg Gln Gln Ser Leu 
        515                 520                 525             


Ala Leu Ile Arg Ser Leu Leu Glu Ser Asp Gly Gly Val Ser Arg Gly 
    530                 535                 540                 


Lys Glu Ile Tyr Phe Thr Asn Thr Ser Arg Pro Leu Ile Glu Gly Leu 
545                 550                 555                 560 


Arg Tyr Gln Leu Leu Arg Leu Gly Val Pro Thr Ala Gly Gln Tyr Arg 
                565                 570                 575     


Glu Arg Arg Gln Asp His Val Gly Gln Arg Ala Asp Gly Ser Pro Ile 
            580                 585                 590         


Arg Phe Glu Gly Val Cys Lys Ala Tyr Asp Leu Arg Ile Pro Ala Val 
        595                 600                 605             


Pro Glu Val Ala Gln Leu Val Gly Cys Gln Pro Ile Ala Lys Arg Asn 
    610                 615                 620                 


Trp Ile Thr Trp Gln Gly Cys Val Tyr Ser Arg Ile Arg Asp Val Gln 
625                 630                 635                 640 


Pro Ile Ala Val Lys Pro Phe Val Phe Asp Leu Lys Val Glu Gly Asp 
                645                 650                 655     


Glu Ser Tyr Met Thr Thr Ser Gly Leu Ala His Asn Ser Thr Tyr Ala 
            660                 665                 670         


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
        675                 680                 685             


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
    690                 695                 700                 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
705                 710                 715                 720 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730         


<210>  303
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Bde-JEL197_RPB2

<400>  303

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ser Gly Asp Thr Glu Val Val Leu Gly Asn Gly Met 
    290                 295                 300                 


Asp Val Val Leu Leu Thr Asp Leu Val Asp Gly Ala Cys Val Ser Thr 
305                 310                 315                 320 


Ile Glu Pro Arg Thr Gly Val Val Ser Pro Ser Leu Ile Asp His Tyr 
                325                 330                 335     


Phe Ala Lys Asp Ala Thr Arg Val Leu Lys Ile Thr Leu Asp Asp Gly 
            340                 345                 350         


Arg Val Ile Lys Ala Asp Pro Glu His Pro Leu Phe Ala Ala Lys Val 
        355                 360                 365             


Asp Glu Thr Thr Arg Gly Leu Thr Gly Gln Trp Leu Arg Val Glu Glu 
    370                 375                 380                 


Leu Thr Val Gly His His Ala Leu Leu Val Ser Pro Gln Gln Ala Tyr 
385                 390                 395                 400 


Cys Thr Ser Glu Gln Trp Thr Leu Thr Leu Ser Glu Lys Glu Val Cys 
                405                 410                 415     


Thr Ala Ser Thr Ala Gln Leu Ala Lys Gln Leu Ser Glu Ile Gly Leu 
            420                 425                 430         


Val Gly Val Pro Ile Pro Leu Ser Lys Val Lys Ser Ala Ala Arg Leu 
        435                 440                 445             


Phe Gly Leu Val Leu Ser Ala Gly Asp Phe Ser Gly Lys Leu Tyr Val 
    450                 455                 460                 


Glu Lys Asp Glu Asp Val Thr Ala Val Asn Ser Asp Leu Thr Ala Leu 
465                 470                 475                 480 


Gly Phe Ser Pro Ala His Trp Val Arg Tyr Gln Asp Asp Gln Gln Lys 
                485                 490                 495     


Trp Phe Lys Cys Asp Asp Ser Asn Gly Lys Ala Ile Cys Ile Thr Leu 
            500                 505                 510         


Val Pro Thr Ala Asn Ala Leu Leu Gln Thr Leu Gly Ala His Asp Ala 
        515                 520                 525             


Glu Lys Gln His Arg Tyr Cys Leu Leu Pro Lys Trp Leu Leu Asp Ala 
    530                 535                 540                 


Pro Thr Ser Ile Lys Arg Glu Phe Leu Gly Ala Leu Phe Gly Gly Asn 
545                 550                 555                 560 


Gly Ala His Ile Thr Ile Ser Cys Asn Glu Gly Lys Trp Glu Pro Thr 
                565                 570                 575     


Met Ser Ala Leu Thr Gln His Thr Asp Ala Asp His Leu Glu Ser Thr 
            580                 585                 590         


Val Val Tyr Leu Lys Gln Val Ala Thr Leu Leu Gly Met Leu Asn Ile 
        595                 600                 605             


Cys Ser Ser Val Ser Ser Glu Lys His Ile Thr Ala Glu Lys Thr Gly 
    610                 615                 620                 


Tyr Ala Val His Leu His Val Asp Asn Thr Ala Glu Asn Leu Val Arg 
625                 630                 635                 640 


Phe Tyr Glu Gln Val Gly Tyr Arg Tyr Cys Phe Asn Lys Thr Ser Gln 
                645                 650                 655     


Ser Ser Ala Pro Val Gln Trp Ile Lys Gly Ser Leu Phe Phe Ile Glu 
            660                 665                 670         


Gln His Arg Ser Lys Cys Gln His Ala Phe Glu Leu Leu His Thr Gly 
        675                 680                 685             


Leu Gly Thr Lys Ala Ala Val Ser Ala Glu Ile Asn Met Pro His His 
    690                 695                 700                 


Asn Pro Ser His Met Leu Asn Val Lys Glu Ile Pro Thr Ala Pro Ala 
705                 710                 715                 720 


Asp Glu Tyr Ile Thr Trp Ile Glu Phe Lys Asp Arg Tyr Val His Lys 
                725                 730                 735     


Glu Ser Pro Arg Phe Val Trp Val Thr Ile His Ser Ile Glu Glu Ala 
            740                 745                 750         


Pro Ala Glu Arg Leu Tyr Asp Phe Asn Thr Val Ser Gln Asn His Ser 
        755                 760                 765             


Phe Phe Ala Asn Ser Ile Val Ser His Asn Ser Thr Tyr Ala Ser Leu 
    770                 775                 780                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
785                 790                 795                 800 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                805                 810                 815     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            820                 825                 830         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840         


<210>  304
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Bde-JEL423_eIF-5B

<400>  304

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Gly Arg Asp Thr Pro Leu Leu Met Ala Asp Gly Thr 
    290                 295                 300                 


Thr Lys Phe Val Gln Asp Ile Lys Ala Leu Asp Gln Leu Met Gly Asp 
305                 310                 315                 320 


Asp Cys Thr Pro Arg Ile Val Gln Glu Arg Ser Leu Val His Glu Ser 
                325                 330                 335     


Gly Ala Leu Tyr Arg Val Val Pro Lys Asn Ala Asn Gly His Asp Ala 
            340                 345                 350         


Phe Val Cys Asn Lys Glu His Ile Leu Val Met Val Asn Val Lys Gln 
        355                 360                 365             


Pro Trp Val Ser Gln Thr Val Ile Asp Gly Val Asp Gln Phe His Val 
    370                 375                 380                 


Ser Glu Val Val Cys Ile Gly Asn Ile Pro Thr Val Arg Ser Ser Gly 
385                 390                 395                 400 


Asn Phe Ala Ser Ala Val Glu Ala Thr Lys Ala Leu Pro Ala Trp Thr 
                405                 410                 415     


Leu Leu Ile Trp Glu Ile Ser Val Leu Glu Tyr Leu Ala Val Asp Ala 
            420                 425                 430         


Asp Leu Arg Gln His Phe Met Ile Tyr Lys Pro Ala Gly Gly Ile Glu 
        435                 440                 445             


Tyr Pro Thr Thr Thr Asn Leu Asp Ile Val Gln His Phe Gly Ala Glu 
    450                 455                 460                 


Ser Val Pro Asn Leu Glu His Ala Val Met Trp Cys Ile Gly Leu Trp 
465                 470                 475                 480 


Ile Leu Leu Gly Asp Val Asp Thr Ala Gly Asn Pro Val Leu Ile Leu 
                485                 490                 495     


Ser Gly Ile Asp His Leu His Pro Leu Ile Lys Thr Leu His Ser His 
            500                 505                 510         


Ser Gln Lys Leu Ser Ile Ser Phe Thr Asn Gln Leu Asp Glu Gly Val 
        515                 520                 525             


Ala Asp Ile Ser Lys Pro Thr Ile Ile Ala Leu Gly Asp Lys Phe Gly 
    530                 535                 540                 


Leu Leu Phe Lys Ser Leu Gly Ile Glu Ser Ala Glu Cys Ile Pro Asp 
545                 550                 555                 560 


Ala Leu Leu Arg Ser Ser Lys Leu His Arg Ala Ala Leu Leu Ala Gly 
                565                 570                 575     


Leu Val Glu Gly Ser Asn Ala Phe Ser Ile Val Lys Asp Thr Pro Lys 
            580                 585                 590         


His Trp Asp Ile Ser Cys Lys Asn Asn Met Ile Phe Glu Asn Ile Lys 
        595                 600                 605             


Arg Leu Ser Ser Ser Leu Gly Leu Cys Val Asp Thr Val Thr Pro Ala 
    610                 615                 620                 


Thr Ile Thr Gln Gln Val Ser Val Lys Thr Leu Gln Ile Arg Ile Ser 
625                 630                 635                 640 


Gly Pro Arg Met His Tyr Val Ser Glu Leu Ile Ser Asn Asp Ser Leu 
                645                 650                 655     


Lys Thr Thr Ser Val Val Ser Ile Asp Ser Trp Leu Asn Val Lys Ser 
            660                 665                 670         


Asn Ala Cys Glu Phe Glu Ile Glu Ser Ile Gly Cys Gly Glu Tyr Phe 
        675                 680                 685             


Gly Phe Thr Val Met Gly Pro Asn Ser Arg Phe Leu Leu Gly Asp Phe 
    690                 695                 700                 


Thr Val Thr His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
705                 710                 715                 720 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                725                 730                 735     


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            740                 745                 750         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        755                 760                 765             


Glu Ala Ala Thr Arg 
    770             


<210>  305
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:BsuP-M1918_RIR1

<400>  305

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Gly Glu Thr Leu Leu Leu Thr Glu Asn Gly Tyr 
    290                 295                 300                 


Glu Lys Ala Ala Asp Leu Tyr Lys Lys Gln Asn Asn Leu Lys Val Val 
305                 310                 315                 320 


Ile Asp Asn Arg Thr Lys Asp Phe Ala Val Asp Ser Lys Gly Thr Thr 
                325                 330                 335     


Ile Val Asp Ala Ile Pro Met Gln Leu Thr Lys Lys Asp Ala Glu Ile 
            340                 345                 350         


Phe Lys Val Lys Thr Lys Gln Gly Tyr Glu Ile Arg Ala Thr Glu Trp 
        355                 360                 365             


His Lys Phe Tyr Val Lys Arg Asp Gly Glu Ile Gln Lys Leu Gln Leu 
    370                 375                 380                 


Asn Gln Leu Lys Thr Gly Asp Lys Leu Leu Val Gln Ser Ala Glu Gly 
385                 390                 395                 400 


Ala Tyr Gly Lys Ile His Glu Pro Asp Leu Ala Tyr Ile Met Gly Ile 
                405                 410                 415     


Ile Ala Gly Asp Gly Thr Ile Thr Glu Lys Thr Ala Lys Ile Tyr Leu 
            420                 425                 430         


Tyr Asp Asn Lys Lys Val Leu Glu Gln Lys Val Thr Asp Ala Val His 
        435                 440                 445             


Arg Ile Ile His Lys His Lys Val Asp Arg Ala Tyr Lys His Asn Thr 
    450                 455                 460                 


Ser Leu Leu Pro Thr Phe Asn Met Ala Asn Pro Glu Lys Gln Asp Leu 
465                 470                 475                 480 


Leu Tyr Met Asn Ser Thr Val Leu Phe Asp Ile Leu Lys Lys Phe Gly 
                485                 490                 495     


Met Asn Lys Glu Arg Lys Thr Arg Val Pro Glu Phe Ile Phe Gln Ala 
            500                 505                 510         


Asn Lys Glu Thr Gln Ala Ala Tyr Leu Ser Gly Leu Phe Gln Thr Asp 
        515                 520                 525             


Gly Cys Val Asn Ala Asn His Lys Ala Lys Ala Leu Thr Ile Glu Leu 
    530                 535                 540                 


Thr Ser Ile His Tyr Glu Ser Leu Gln Asp Val Gln Lys Leu Leu Leu 
545                 550                 555                 560 


Asn Met Gly Val Tyr Thr Thr Ile Tyr Ser Asn Asn Lys Arg Ser Gln 
                565                 570                 575     


Glu Leu Leu Pro Asp Gly Lys Gly Gly Ser Lys Leu Tyr Asn Val Lys 
            580                 585                 590         


Pro Thr His Lys Ile Ser Ile Gln Asp Arg Asn Ser Arg Glu Leu Phe 
        595                 600                 605             


Met Ser Ile Val Glu Leu Lys Asp Tyr Asp Val Tyr Lys Phe Asn Leu 
    610                 615                 620                 


Leu Thr Glu Thr Leu Gln Pro Lys Ser Arg Lys Pro Lys His Asp Phe 
625                 630                 635                 640 


Thr Ala Glu Ile Ile Ser Ile Glu Glu Asp Gly Val Glu Asp Val Tyr 
                645                 650                 655     


Asp Thr Thr Gln Glu Asp Tyr His Ser Leu Ile Phe Asn Gly Ile Val 
            660                 665                 670         


Thr Gly Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
        675                 680                 685             


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
    690                 695                 700                 


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
705                 710                 715                 720 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
                725                 730                 735     


Ala Thr Arg 
            


<210>  306
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Cag_RIR1

<400>  306

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Ala Asp Thr Leu Ile Ala Thr Asp Arg Gly Leu 
    290                 295                 300                 


Glu Arg Ile Gly Asn Ile Val Gly Glu Ser Arg Gly Ile Lys Ser Ile 
305                 310                 315                 320 


Asp Gly Lys Leu His Trp Val Glu Asn Ile Phe Pro Thr Gly Thr Lys 
                325                 330                 335     


Pro Val Tyr Gln Leu Arg Thr Lys Ser Gly Tyr Gln Leu Lys Leu Thr 
            340                 345                 350         


Gly Asp His Val Val Phe Thr Glu Asn Arg Gly Asp Val Lys Ala Cys 
        355                 360                 365             


Glu Leu Arg Lys Asp Asp Met Val Arg Leu Val Gly Ala Pro Phe Gly 
    370                 375                 380                 


Lys Glu Thr Thr Gly Ser Thr Asp Ile Ala Gln Leu Ile Gly Leu Leu 
385                 390                 395                 400 


Thr Gly Asp Gly Cys Ile Thr Thr Ala Asn Glu Ile Ala Ala Ser Gly 
                405                 410                 415     


Glu Gln Arg Arg Thr Ala Phe Leu Thr Val Ser Lys Ala Glu Gln Glu 
            420                 425                 430         


Ile Ala Glu Trp Ala Asn Gln Phe Ile Asn Thr Leu Arg Pro Glu Leu 
        435                 440                 445             


Gly Glu His Asn Lys Ser Gly Ser Val Thr Glu Thr Ala Thr Thr Ala 
    450                 455                 460                 


Arg Val Ala Val Gly Ser Pro Arg Ile Leu Lys Gln Phe Glu Ala Phe 
465                 470                 475                 480 


Ala Val Leu Asp Lys Gly Ser Val His Lys Leu Phe Thr Asp Lys Val 
                485                 490                 495     


Phe Gln Leu Ala Gln Ser Glu Gln Ala Ala Leu Leu Arg Gly Leu Phe 
            500                 505                 510         


Thr Ala Asp Gly Thr Val Ala Asn Tyr Ser Asp Lys Ser Gln Tyr Ile 
        515                 520                 525             


Ala Leu Asp Ala Thr Ser Leu Glu Leu Leu Gln Gln Val Gln Leu Leu 
    530                 535                 540                 


Leu Phe Asn Phe Gly Ile Lys Ser Lys Ile Tyr Glu Asn Arg Arg Val 
545                 550                 555                 560 


Gly Glu Leu Val Ser Leu Leu Pro Asp Gly Lys Gly Gly Ile Lys Glu 
                565                 570                 575     


Tyr Pro Val Gln Gln Met His Ser Leu Arg Ile Ser Arg Ser Ser Arg 
            580                 585                 590         


Ile Leu Phe Glu Gln Gln Ile Gly Phe Met Ala Glu Ser Lys Lys Tyr 
        595                 600                 605             


Glu Ala Leu Ala Glu Leu Asn Arg Thr Val Ser Thr Tyr Arg Asp Ser 
    610                 615                 620                 


Ala Tyr Asp Ala Val Ala Ser Leu Thr Tyr Ser Gly Glu Glu Ala Val 
625                 630                 635                 640 


Phe Asp Leu Thr Glu Pro Glu Thr Asp His Phe Ile Ala Asn Gly Ile 
                645                 650                 655     


Gly Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
            660                 665                 670         


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
        675                 680                 685             


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
    690                 695                 700                 


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
705                 710                 715                 720 


Ala Ala Thr Arg 
                


<210>  307
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Cau_SpoVR

<400>  307

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu His Gly Asp Ser Leu Ile Val Thr Asp His Gly Leu 
    290                 295                 300                 


Val Pro Met Arg Glu Val Val Asn His Arg Gln Arg Leu Gln Val Ser 
305                 310                 315                 320 


Asp Gly Glu Arg Gln Gln Thr Val Tyr Asp Trp Asn Arg Phe Ala Asp 
                325                 330                 335     


Tyr Pro Thr Val Thr Met Arg Thr Arg Ala Gly Phe Thr Leu Thr Gly 
            340                 345                 350         


Ser His Asn His Arg Ile Met Leu Ala Asp Gly Thr Trp Arg Arg Leu 
        355                 360                 365             


Asp Glu Leu Gln Ile Gly Asp Arg Val Arg Ile Ala Gly Gly Thr Glu 
    370                 375                 380                 


Leu Trp Ala Thr Glu Pro Ala Leu Leu Arg Cys Arg Arg Pro Leu Pro 
385                 390                 395                 400 


Arg Val Leu Val Thr Ala Gly Ala Pro Ala Ala Thr Thr Ser Ser Pro 
                405                 410                 415     


His Arg Arg Gly Tyr Arg Arg Ala Ala Ala Val Val Val Asp Glu Lys 
            420                 425                 430         


Leu Ala Ala Ala Ile Gly Arg Arg Cys Val Thr His Ala Asp Gln Gln 
        435                 440                 445             


Ala Leu Asp Ala Ile Arg Arg Ser Pro Arg Pro Gln Val Val Ala Phe 
    450                 455                 460                 


Leu Arg Ala Phe Cys Gln Gly Ala Gly Gln Ser Val Ala Ser Gly Leu 
465                 470                 475                 480 


Thr Leu Thr Cys Ala Asp Ala Asp Leu Ala Thr Thr Val Gln Leu Leu 
                485                 490                 495     


Leu Thr Asn Leu Gly Val Leu Ala His Arg Thr Asp Thr Thr Val Arg 
            500                 505                 510         


Ile Asp Asn Gly Asp Asp Leu Glu Arg Ala Tyr Thr Thr Leu Ala Thr 
        515                 520                 525             


Pro Thr Gly Trp Thr Asp Glu Val Val Ala Leu Glu His Gly Thr Ala 
    530                 535                 540                 


Asp Val Tyr Asp Ile Ser Val Thr Ala Thr His Arg Tyr Ala Ala Gln 
545                 550                 555                 560 


Gly Phe Ile Asn His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
                565                 570                 575     


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
            580                 585                 590         


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
        595                 600                 605             


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
    610                 615                 620                 


Ala Glu Ala Ala Thr Arg 
625                 630 


<210>  308
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Cbu_DnaB

<400>  308

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Gly Asp Thr Leu Ile Cys Leu Ala Asp Gly Arg 
    290                 295                 300                 


Arg Val Pro Ile Gln Asp Leu Val Gly His Ser Pro Glu Val Ile Ala 
305                 310                 315                 320 


Val Asp Asp Lys Gly Arg Leu Val Cys Ala Lys Ser Glu Val Ile Trp 
                325                 330                 335     


Lys Val Gly Glu Arg Ser Val Phe Glu Ile Lys Leu Ala Ser Gly Arg 
            340                 345                 350         


Ser Ile Lys Ala Thr Ala Glu His Arg Leu Leu Ala Phe Lys Gly Trp 
        355                 360                 365             


Arg His Val Lys Asp Phe Lys Val Gly Asp Arg Leu Ala Ile Ala His 
    370                 375                 380                 


Gln Val Pro Glu Pro Asp Arg Leu Leu Gln His Cys Gln Ser Asp Leu 
385                 390                 395                 400 


Phe Trp Asp Arg Ile Val Ser Ile Glu Glu Lys Gly Ser Glu Glu Val 
                405                 410                 415     


Tyr Asp Leu Thr Val Pro Lys Tyr Ala Ser Trp Leu Ala Asp Gly Val 
            420                 425                 430         


Val Ser His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
        435                 440                 445             


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
    450                 455                 460                 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
465                 470                 475                 480 


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
                485                 490                 495     


Ala Ala Thr Arg 
            500 


<210>  309
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ceu_ClpP

<400>  309

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Ser Asp His Thr Val Leu Thr Thr Arg Gly Trp 
    290                 295                 300                 


Ile Pro Ile Ala Asp Val Thr Leu Asp Asp Lys Val Ala Val Leu Asp 
305                 310                 315                 320 


Asn Asn Thr Gly Glu Met Ser Tyr Gln Asn Pro Gln Lys Val His Lys 
                325                 330                 335     


Tyr Asp Tyr Glu Gly Pro Met Tyr Glu Val Lys Thr Ala Gly Val Asp 
            340                 345                 350         


Leu Phe Val Thr Pro Asn His Arg Met Tyr Val Asn Thr Thr Asn Asn 
        355                 360                 365             


Thr Thr Asn Gln Asn Tyr Asn Leu Val Glu Ala Ser Ser Ile Phe Gly 
    370                 375                 380                 


Lys Lys Val Arg Tyr Lys Asn Asp Ala Ile Trp Asn Lys Thr Asp Tyr 
385                 390                 395                 400 


Gln Phe Ile Leu Pro Glu Thr Ala Thr Leu Thr Gly His Thr Asn Lys 
                405                 410                 415     


Ile Ser Ser Thr Pro Ala Ile Gln Pro Glu Met Asn Ala Trp Leu Thr 
            420                 425                 430         


Phe Phe Gly Leu Trp Ile Ala Asn Gly His Thr Thr Lys Ile Ala Glu 
        435                 440                 445             


Lys Thr Ala Glu Asn Asn Gln Gln Lys Gln Arg Tyr Lys Val Ile Leu 
    450                 455                 460                 


Thr Gln Val Lys Glu Asp Val Cys Asp Ile Ile Glu Gln Thr Leu Asn 
465                 470                 475                 480 


Lys Leu Gly Phe Asn Phe Ile Arg Ser Gly Lys Asp Tyr Thr Ile Glu 
                485                 490                 495     


Asn Lys Gln Leu Trp Ser Tyr Leu Asn Pro Phe Asp Asn Gly Ala Leu 
            500                 505                 510         


Asn Lys Tyr Leu Pro Asp Trp Val Trp Glu Leu Ser Ser Gln Gln Cys 
        515                 520                 525             


Lys Ile Leu Leu Asn Ser Leu Cys Leu Gly Asn Cys Leu Phe Thr Lys 
    530                 535                 540                 


Asn Asp Asp Thr Leu His Tyr Phe Ser Thr Ser Glu Arg Phe Ala Asn 
545                 550                 555                 560 


Asp Val Ser Arg Leu Ala Leu His Ala Gly Thr Thr Ser Thr Ile Gln 
                565                 570                 575     


Leu Glu Ala Ala Pro Ser Asn Leu Tyr Asp Thr Ile Ile Gly Leu Pro 
            580                 585                 590         


Val Glu Val Asn Thr Thr Leu Trp Arg Val Ile Ile Asn Gln Ser Ser 
        595                 600                 605             


Phe Tyr Ser Tyr Ser Thr Asp Lys Ser Ser Ala Leu Asn Leu Ser Asn 
    610                 615                 620                 


Asn Val Ala Cys Tyr Val Asn Ala Gln Ser Ala Leu Thr Leu Glu Gln 
625                 630                 635                 640 


Asn Ser Gln Lys Ile Asn Lys Asn Thr Leu Val Leu Thr Lys Asn Asn 
                645                 650                 655     


Val Lys Ser Gln Thr Met His Ser Gln Arg Ala Glu Arg Val Asp Thr 
            660                 665                 670         


Ala Leu Leu Thr Gln Lys Glu Leu Asp Asn Ser Leu Asn His Glu Ile 
        675                 680                 685             


Leu Ile Asn Lys Asn Pro Gly Thr Ser Gln Leu Glu Cys Val Val Asn 
    690                 695                 700                 


Pro Glu Val Asn Asn Thr Ser Thr Asn Asp Arg Phe Val Tyr Tyr Lys 
705                 710                 715                 720 


Gly Pro Val Tyr Cys Leu Thr Gly Pro Asn Asn Val Phe Tyr Val Gln 
                725                 730                 735     


Arg Asn Gly Lys Ala Val Trp Thr Gly Asn Ser Thr Tyr Ala Ser Leu 
            740                 745                 750         


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
        755                 760                 765             


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
    770                 775                 780                 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
785                 790                 795                 800 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                805                 810 


<210>  310
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Chy_RIR1

<400>  310

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Gly Asp Thr Leu Val Phe Thr Asp Lys Gly Leu 
    290                 295                 300                 


Ile Glu Ala Arg Lys Leu Glu Val Gly Met Lys Val Trp Ser Gly Asp 
305                 310                 315                 320 


Gly Trp Asn Glu Ile Lys Glu Val Ile Asn Asn Gly Val Lys Pro Val 
                325                 330                 335     


Leu Lys Leu Lys Leu Lys Thr Gly Leu Glu Ile Lys Val Thr Glu Glu 
            340                 345                 350         


His Lys Ile Phe Thr Gly Glu Gly Trp Lys Glu Ala Lys Asp Leu Lys 
        355                 360                 365             


Val Gly Asp Lys Leu Tyr Leu Pro Val Ser Tyr Pro Glu Leu Asp Phe 
    370                 375                 380                 


Pro Val Lys Glu Glu Asn Asp Phe Tyr Glu Phe Leu Gly Tyr Phe Leu 
385                 390                 395                 400 


Gly Asp Gly Ser Leu Ser Val Ser Asn His Val Ser Leu His Val Gly 
                405                 410                 415     


Asn Asp Lys Glu Leu Ala Leu Tyr Phe Lys Glu Lys Val Glu Lys Tyr 
            420                 425                 430         


Ala Gly Ala Ala Tyr Leu Ile Glu Arg Asp Gly Gln Tyr Ile Ile Asp 
        435                 440                 445             


Val His Arg Lys Glu Phe Ala Glu Lys Ile Lys Lys Ile Phe Gly Ile 
    450                 455                 460                 


Glu Ile Thr Asp Ser Lys Glu Lys Asp Ile Pro Ser Ser Leu Leu Ala 
465                 470                 475                 480 


Val Asn Ser Glu Ala Met Lys Ala Leu Leu Arg Gly Leu Phe Ser Ala 
                485                 490                 495     


Asp Gly Ser Val Tyr Asp Ala Asn Gly Ser Ile Thr Val Ala Leu Ser 
            500                 505                 510         


Ser Thr Ser Tyr Pro Leu Leu Arg Lys Val Gln Ile Leu Leu Leu Ser 
        515                 520                 525             


Leu Gly Ile Pro Ser Thr Leu Thr Gly Glu Lys Asp Gln Asp Val Lys 
    530                 535                 540                 


Ile Ile Lys Gly Asn Glu Tyr Glu Thr Leu Pro Thr Tyr Arg Leu Ile 
545                 550                 555                 560 


Ile Ser Gly Glu Arg Ala Ser Leu Phe Phe Asn Lys Ile Gly Leu Ile 
                565                 570                 575     


Gly Glu Lys Lys Lys Lys Phe Leu Glu Leu Met Ala Gly Lys Thr Thr 
            580                 585                 590         


Tyr Ser Thr Leu Asn Asn His Leu Tyr Gln Glu Ile Val Ser Ile Glu 
        595                 600                 605             


Pro Ala Gly Glu Glu Glu Val Phe Asp Ile Thr Ala Pro Pro Lys Tyr 
    610                 615                 620                 


Thr Trp Ile Thr Asn Gly Ile Leu Ser Leu Asp Ser Thr Tyr Ala Ser 
625                 630                 635                 640 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
                645                 650                 655     


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
            660                 665                 670         


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
        675                 680                 685             


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695                 


<210>  311
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Cth_ATPase_BIL

<400>  311

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Val Ala Gly Thr Met Ile Leu Thr Val Ala Gly Leu 
    290                 295                 300                 


Val Ala Ile Glu Asn Ile Lys Ala Gly Asp Lys Val Ile Ala Thr Asn 
305                 310                 315                 320 


Pro Glu Thr Phe Glu Val Ala Glu Lys Thr Val Leu Glu Thr Tyr Val 
                325                 330                 335     


Arg Glu Thr Thr Glu Leu Leu His Leu Thr Ile Asn Gly Asp Val Ile 
            340                 345                 350         


Lys Thr Thr Phe Glu His Leu Phe Tyr Ala Lys Asp Val Gly Phe Val 
        355                 360                 365             


Glu Ala Lys Glu Leu Gln Val Gly Asp Lys Leu Leu Asp Ser Lys Gly 
    370                 375                 380                 


Asn Val Leu Val Val Glu Asp Lys Lys Ile Lys Ile Thr Asp Glu Pro 
385                 390                 395                 400 


Val Lys Val Tyr Asn Phe Gln Val Asp Asp Phe His Thr Tyr His Val 
                405                 410                 415     


Gly Cys Asn Gly Val Leu Val His Asn Ser Thr Tyr Ala Ser Leu Asn 
            420                 425                 430         


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
        435                 440                 445             


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
    450                 455                 460                 


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
465                 470                 475                 480 


Leu Val Asn Ala Glu Ala Ala Thr Arg 
                485                 


<210>  312
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Cth_TerA

<400>  312

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Gln Leu Ala Leu Asp Thr Pro Ile Pro Thr Pro Asp Gly Trp 
    290                 295                 300                 


Thr Thr Met Gly Glu Ile Lys Ala Gly Asp Lys Val Ile Asp Glu Lys 
305                 310                 315                 320 


Gly Arg Pro Cys Asn Val Val Ala Ile Ser Glu Ile Asp Asp Thr Glu 
                325                 330                 335     


Gln Ala Tyr Lys Ile Asn Phe Arg Asp Gly Thr Ser Ile Val Ala Gly 
            340                 345                 350         


Glu Arg His Leu Trp Lys Val Gln Val Thr Asn Asn Gly Arg Arg Glu 
        355                 360                 365             


Lys Leu Leu Thr Thr Gly Glu Met Tyr Gln Lys Gln Phe Lys Thr Lys 
    370                 375                 380                 


Ser Lys Glu Asn Arg Ala Leu Phe Arg Ile Pro Ile Ala Asp Ala Phe 
385                 390                 395                 400 


Ile Leu Pro Glu Asn Lys Leu Pro Ile Asp Pro Tyr Leu Phe Gly Tyr 
                405                 410                 415     


Trp Ile Gly Asn Gly Asn Ala Val Lys Pro Glu Ile Thr Val Met Arg 
            420                 425                 430         


Asp Asp Val Asp Glu Val Ile Lys Asn Ile Pro Tyr Lys Leu His Asn 
        435                 440                 445             


Arg Tyr Lys Gln Glu Gly Asn Ser Asp Ile Leu Val Tyr Lys Glu Leu 
    450                 455                 460                 


Lys Ser Ile Leu Val Lys Asn Phe Arg Glu Lys Arg Ile Pro Ile Glu 
465                 470                 475                 480 


Tyr Leu Arg Ala Ser Ala Gln Gln Arg Lys Arg Leu Leu Gln Gly Leu 
                485                 490                 495     


Ile Asp Ser Asp Gly Cys Val Ser Thr Ala Lys Ser Gln Ala Ile Tyr 
            500                 505                 510         


Val Thr Ile Leu Phe Glu Leu Ala Lys Asp Val Gln Asp Leu Leu Trp 
        515                 520                 525             


Ser Leu Gly Ile Lys Asn Thr Leu Lys Thr Ala Pro Ser Ala Arg Tyr 
    530                 535                 540                 


Gly Ile Glu Thr Gly Glu Ile Cys Tyr Leu Ile Lys Phe Thr Ala Phe 
545                 550                 555                 560 


Asn Asp Leu Glu Val Ser Gly Leu Asp Arg Lys Leu Lys Arg Gly Arg 
                565                 570                 575     


Glu Arg Asn Ile Lys Thr Arg Ser His Phe His Tyr Ile Lys Ser Ile 
            580                 585                 590         


Glu Lys Thr Gly Lys Thr Lys Met Arg Cys Ile Gln Val Asp Ser Pro 
        595                 600                 605             


Ser Arg Leu Tyr Leu Ala Gly Lys Ser Met Ile Pro Thr His Asn Ser 
    610                 615                 620                 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
625                 630                 635                 640 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
                645                 650                 655     


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
            660                 665                 670         


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680                 685         


<210>  313
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:CV-NY2A_RIR1

<400>  313

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ala Gly Asp Thr Lys Ile Leu Thr Ser Ser Gly Tyr 
    290                 295                 300                 


His Pro Ile Lys Asp Met Glu Gly Lys Gln Val Arg Val Trp Asn Gly 
305                 310                 315                 320 


Tyr Glu Phe Ser Glu Thr Ile Val His Lys Thr Gly Val Asn Gln Lys 
                325                 330                 335     


Leu Ile Met Val Ser Leu Asp Asp Gly Thr Glu Leu Arg Cys Thr Pro 
            340                 345                 350         


Tyr His Lys Phe Tyr Ile Glu Thr Gly Ser Arg Pro Ala Asp Lys Ser 
        355                 360                 365             


Arg Val Met Glu Val Arg Ala Gly Asp Leu Glu Lys Gly Asp Arg Ile 
    370                 375                 380                 


Ile Arg Phe Glu Leu Pro Thr Ile Thr Val Gly Glu Thr Thr Met Ser 
385                 390                 395                 400 


Asp Lys Glu Ala Tyr Thr Lys Gly Phe Phe Ser Ala Asp Gly Cys Val 
                405                 410                 415     


Ile Lys Ser Lys Tyr Gly Glu Asp Glu Tyr Arg Ile Ser Val Lys Arg 
            420                 425                 430         


Glu Asp Lys Ile Glu Ala Leu Thr Lys Tyr Val Asp Val Ile Lys Ser 
        435                 440                 445             


His Thr Asn Arg Phe Arg Thr His Phe Tyr Val Pro Asp Tyr Val Gln 
    450                 455                 460                 


Asn Lys Phe Glu Val Pro Ile Asn Ser Met Val Asn Glu Lys Ile Ser 
465                 470                 475                 480 


Trp Leu Ala Gly Phe Met Asp Gly Asp Gly Cys Val Ile Arg Tyr Lys 
                485                 490                 495     


Asp Ile Glu Asn Met Gln Ala Val Ser Ile Asn Lys Ser Phe Leu Gln 
            500                 505                 510         


Asp Ile Arg Leu Met Leu Gln Thr Ile Gly Ile His Ser Thr Ile Asn 
        515                 520                 525             


Lys Phe Met Pro Asn Arg Val Met Lys Met Pro Asp Gly Arg Gly Gly 
    530                 535                 540                 


Thr Asp Met Tyr Asn Gly Ala Glu Ser Trp Arg Leu Gln Ile Asp Ser 
545                 550                 555                 560 


Glu Gly Val Arg Lys Leu Phe Ala Leu Gly Phe Thr Pro Arg Arg Leu 
                565                 570                 575     


Lys Met Asn Gly Ser Arg Lys Arg His His Lys Thr Asn Lys Phe Thr 
            580                 585                 590         


Arg Val Val Ser Val Thr Asp His Gly Asp Val Glu Asp Thr Tyr Cys 
        595                 600                 605             


Phe Asn Glu Pro Lys Arg His Met Gly Val Phe Asn Gly Val Ile Thr 
    610                 615                 620                 


Gly Gln Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
625                 630                 635                 640 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
                645                 650                 655     


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
            660                 665                 670         


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
        675                 680                 685             


Thr Arg 
    690 


<210>  314
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Cwa_PEP

<400>  314

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Asp Gly Lys Thr Lys Ile Leu Thr Asn Gln Gly Phe 
    290                 295                 300                 


Met Thr Leu Arg Gln Val Tyr Glu Gln Gly Tyr Glu Gly Leu Ser Thr 
305                 310                 315                 320 


Leu Ser Leu Asn Thr Lys Thr His Lys Ile Glu Trp Lys Pro Ile Leu 
                325                 330                 335     


Asp Thr Met Lys Arg Gln Ser Glu Met Ile Asp Ile Ser Val Ser Gln 
            340                 345                 350         


Thr Gly Arg Ile Thr Asp Asn Thr Leu Arg Leu Thr Pro Asp His Lys 
        355                 360                 365             


Met Val Asn Leu Arg Gly Gly Lys Tyr Thr Lys Thr Glu Ile Gln Asp 
    370                 375                 380                 


Leu Leu Lys Gln Gln Glu Met Leu Thr Val Ala Gln Thr Ile Pro Ser 
385                 390                 395                 400 


Leu Gly Asn Asn Lys His Gln Glu Ala Asp Leu Ala Tyr Phe Leu Gly 
                405                 410                 415     


Gly Ile Ile Thr Asp Gly Ser Ile Tyr Thr Ser Ser Thr Arg Gly Glu 
            420                 425                 430         


Val Gln Phe Ile Gln Lys Asp Val Pro Glu Lys Gln Ala Phe Ile Ser 
        435                 440                 445             


Lys Met Asn Asp Leu Ala Asn Ser Leu Tyr Gly Lys Ser Phe Thr Ala 
    450                 455                 460                 


His Ile Lys Pro Val Ser Ser Ser Tyr Ile Arg Gly Gln Lys Val Thr 
465                 470                 475                 480 


Gly Gln Ala Thr Ala Tyr Arg Leu His Ser Lys Ala Ile Ala Tyr Asp 
                485                 490                 495     


Val Lys Glu Arg Glu Asn Asn Ile Thr Gln Leu Leu Leu Glu Asn Glu 
            500                 505                 510         


Ala Glu Leu Ser Tyr His Phe Leu Gly Gly Val Ile Asp Gly Asp Gly 
        515                 520                 525             


Cys Tyr His Lys Asn Arg Leu His Ile Tyr Ile Ser Glu Glu Asn Leu 
    530                 535                 540                 


Leu Gln Ala Val Ile Ile Ala Cys Leu Lys Met Asn Thr Val Pro Gln 
545                 550                 555                 560 


Val Thr Lys Asn Arg Asn Ile Tyr His Leu Gln Ile Val Glu Lys Leu 
                565                 570                 575     


Glu Val Ile Leu Arg Tyr Thr Gln Arg Val Lys Gly Glu Val Thr Pro 
            580                 585                 590         


Arg Thr Ile Gln Thr Arg Phe Phe Ala Thr Arg Gln Leu Phe Glu Asn 
        595                 600                 605             


Gln Glu Thr Gly Gln Ile Lys Leu Arg Gln Asp Asn Asn Cys Leu Ile 
    610                 615                 620                 


Ser Asp Lys Gln Leu Arg Glu Met Gly Glu Phe Glu Glu Leu Ile Asp 
625                 630                 635                 640 


Gly Asp Thr Arg Met Gln Arg Val Ile Gln Val Gly Glu Lys Ser Asp 
                645                 650                 655     


Gly Asp Val Tyr Asn Ile Thr Val Ala Glu His His Asn Tyr Val Val 
            660                 665                 670         


Phe Thr Ala Lys Tyr Thr Pro Val Val Val Cys Asn Ser Thr Tyr Ala 
        675                 680                 685             


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
    690                 695                 700                 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
705                 710                 715                 720 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
                725                 730                 735     


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            740                 745             


<210>  315
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Cwa_RIR1

<400>  315

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ala Pro Glu Thr Lys Ile Leu Thr Asp Arg Gly Gln 
    290                 295                 300                 


Ile Ala Ile Ala Asp Val Ala Gly Glu Lys Val Asn Ile Trp Asn Gly 
305                 310                 315                 320 


Ser Glu Trp Ser Glu Val Leu Val Lys Lys Thr Gly Glu Asn Gln Pro 
                325                 330                 335     


Leu Leu Lys Val His Phe Ser Asn Gly Glu Ser Leu Asp Cys Thr Tyr 
            340                 345                 350         


Tyr His Lys Phe His Val Gln Glu Asn Tyr Lys Gly Lys Val Lys Ile 
        355                 360                 365             


Val Glu Ala Lys Asp Leu Gln Glu Gly Asp Lys Leu Ile Lys Tyr Arg 
    370                 375                 380                 


Leu Pro Leu Val Glu Ser Glu Asn Asp Ile Asp Phe Pro Tyr Ala Tyr 
385                 390                 395                 400 


Thr Ser Gly Phe Phe Ser Gly Asp Gly Ser His Asp Gly Met Gly Lys 
                405                 410                 415     


Pro Glu Ile Asp Leu Tyr Gly Glu Lys Lys Glu Leu Leu Pro Phe Val 
            420                 425                 430         


Thr Val Arg Asn Lys Tyr Tyr Gly Gly Ser Tyr Gly Asp Lys Ser Trp 
        435                 440                 445             


Arg Ile Glu Arg Asp Glu Val Ala Val Tyr Asp Asp Val Asn Gln Asp 
    450                 455                 460                 


Arg Ile Val Cys Lys Leu Pro Leu Asp Ile Pro Ala Lys Phe Thr Val 
465                 470                 475                 480 


Pro Val Asn Gly Tyr Thr Ile Gln Ser Arg Leu Glu Trp Leu Ala Gly 
                485                 490                 495     


Leu Leu Asp Ala Asp Gly Thr Val Ala Arg Asn Gly Asp Asn Glu Ser 
            500                 505                 510         


Leu Gln Val Ala Ser Thr His Gln Gln Phe Leu Leu Asp Ile Arg Leu 
        515                 520                 525             


Met Leu Gln Thr Leu Gly Val Asp Ser Lys Val Val Lys Met Asp Glu 
    530                 535                 540                 


Met Gly Tyr Arg Ser Leu Pro Asp Gly Lys Gly Gly Tyr Gln Asp Tyr 
545                 550                 555                 560 


Phe Cys Gln Ala Lys Tyr Arg Leu Leu Ile Ser Ser Asn Gly Leu Phe 
                565                 570                 575     


Gln Leu Gly Glu Leu Gly Leu Lys Thr Asn Arg Leu Gln Trp Asn Leu 
            580                 585                 590         


Arg Glu Pro Gln Arg Glu Ala Ser Gln Phe Ile Arg Val Glu Lys Val 
        595                 600                 605             


Glu Leu Thr Cys Arg Tyr Asp Asp Thr Tyr Cys Phe Ser Glu Pro Lys 
    610                 615                 620                 


Arg His Leu Gly Met Phe Asn Gly Ile Leu Thr Gly Gln Ser Thr Tyr 
625                 630                 635                 640 


Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
                645                 650                 655     


Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile 
            660                 665                 670         


Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu 
        675                 680                 685             


Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695                 700     


<210>  316
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Dhan_GLT1

<400>  316

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ala Ser Asp Thr Leu Val Arg Thr Ser Glu Gly Asp 
    290                 295                 300                 


Lys Pro Val Ala Glu Val Ala Ile Gly Asp Tyr Leu Leu Asp Ala Glu 
305                 310                 315                 320 


Asp Lys Pro Val Leu Cys Met Gly Ala Asn Pro Ser Gln Thr Gly Arg 
                325                 330                 335     


Met Lys Glu Ile Ala Tyr Gln Asp Phe Asp Ser Lys Lys Arg Val Ser 
            340                 345                 350         


Phe Lys Cys Thr Pro Asp His His Leu Glu Leu Thr Leu Thr Asp Ser 
        355                 360                 365             


Thr Pro Ser Leu Ser Gly Lys Ser Val Thr Trp Phe Ser Arg Cys Thr 
    370                 375                 380                 


Gly Ala His Leu Ser Glu Glu Val Ser Glu Val Tyr Leu Asp Asn Met 
385                 390                 395                 400 


Val Ser Ile Phe Tyr Asn Asp Leu Val Asp Ser Thr Asp Ser Ala Val 
                405                 410                 415     


Asp Lys Asp Ser Ile His Glu Ala Val Asp Leu Ala Leu Glu Asp His 
            420                 425                 430         


Tyr His Arg Gly Asn Ser Asp Gln Tyr Ser Ile His Leu Asn Glu Tyr 
        435                 440                 445             


Ile Ser Arg Ile Ala Asp Lys Glu Leu Gln Asn Glu Pro Glu Phe Ile 
    450                 455                 460                 


Arg Glu Cys Ile His Asp Ala Ala Asn Arg Phe Val Ile Thr Ser Ser 
465                 470                 475                 480 


Gly Asn Arg Asn Ile Lys Ser Glu Ser Phe Asp Asp Lys Leu Leu Leu 
                485                 490                 495     


Ser Arg Ser Arg Ser Ser Thr Ala Asp Ser Asp Ser Asp Tyr Val Ile 
            500                 505                 510         


Thr Asp Ala Ser Val His Ser His Ser Asn Asn Ser Ser Val Tyr Leu 
        515                 520                 525             


Ala Ser Pro Asp Ser Met Ile Pro Asp Gly Ala Ala Asn Arg Phe Glu 
    530                 535                 540                 


Asn Ile Ala Ser Lys Leu Lys Glu Pro Val Cys Asn Cys Gly Gly Ile 
545                 550                 555                 560 


Arg Lys Ile Phe Arg Ser Phe Gly Thr Thr Glu Asp Ala Glu Leu Ala 
                565                 570                 575     


Tyr Ser Leu Leu Leu Ser Glu His Tyr Tyr Arg Leu Asp Pro Arg Phe 
            580                 585                 590         


Val Thr Asp Gly Tyr Thr Phe Gln Ala Ser Val Glu Gln Tyr Glu Asn 
        595                 600                 605             


Met Cys Ser Gln Glu Val Gln Asn Met His Leu Lys Leu Tyr Arg Ser 
    610                 615                 620                 


Pro Leu Lys Phe Val Glu Arg Glu His Asn Ser Ala Glu Leu Pro Val 
625                 630                 635                 640 


Asp Pro Tyr Phe Leu Gly Leu Trp Leu Gly Asp Gly Asp Ser Ser Gly 
                645                 650                 655     


Thr Thr Ile Met Thr Thr Asp Arg Glu Ile Val Val Trp Leu Asn Ser 
            660                 665                 670         


Tyr Val Glu Arg Leu Asn Gln Asn Lys Pro Glu Gly Cys Phe Pro Leu 
        675                 680                 685             


Lys Leu Thr Glu Gln Leu Ile Tyr Gly Ala Gly His Thr Ser Lys Ser 
    690                 695                 700                 


Gly His Thr Thr Lys Val Asp Val Arg Asn Tyr Lys Ile Ser Ser Gly 
705                 710                 715                 720 


Asp Ala Phe Val Arg Ser Gly Thr Tyr Trp Asn Pro Ile Phe Asp Gly 
                725                 730                 735     


Leu Lys Lys Leu Gly Leu Leu Asn Asn Lys Ser Ala Gly Ile Pro Gln 
            740                 745                 750         


Glu Tyr Met Asn Ser Asp Glu Gln Asn Arg Leu Ser Val Ile Ala Gly 
        755                 760                 765             


Leu Met Asp Ser Asp Gly Cys Tyr Val Lys Ser His Asn Thr Tyr Arg 
    770                 775                 780                 


Phe Thr Gln Leu Thr Glu Asp His Lys Lys Ile Val Tyr Asp Leu Lys 
785                 790                 795                 800 


Glu Leu Ala Leu Ser Cys Gly Ile Asn Thr Thr Gly Val Glu Leu Ser 
                805                 810                 815     


Val Lys Pro Leu Gly Phe Asn Lys His Lys His Ser Thr Glu Tyr Val 
            820                 825                 830         


Val Tyr Leu Gly Asn Gly Ser Gln Lys Phe Gln Glu Leu Leu Leu Leu 
        835                 840                 845             


Pro Arg Lys Lys Met Glu Ile Ser Lys Lys His Val Ser Leu Asp Ala 
    850                 855                 860                 


Arg Pro Phe Thr Val Ser Asp Val Glu Asp Gly Glu Phe Arg Ala Ile 
865                 870                 875                 880 


Glu Val Ser Gly Gly Val Phe Gln Leu Ala Asn Arg Leu Val Val Ala 
                885                 890                 895     


Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
            900                 905                 910         


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
        915                 920                 925             


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
    930                 935                 940                 


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
945                 950                 955                 960 


Arg 
    


<210>  317
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Fsp-CcI3_RIR1

<400>  317

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Gln Pro Tyr Asp Ala Leu Val Ser Thr Pro Ser Gly Leu 
    290                 295                 300                 


Val Pro Ile Gly Ala Leu Val Glu Thr Asp Ala Val Gly Met Lys Val 
305                 310                 315                 320 


Phe Asp Ala His Gly Leu Thr Gln Val Ile Ala Thr Lys Ser Asn Gly 
                325                 330                 335     


Val Lys Asp Val Leu Arg Ile Trp Thr Arg Ala Gly His Ala Leu Asp 
            340                 345                 350         


Val Thr Ala Asp His Leu Val Trp Arg Ser Thr Ser Ala Gly Ala Gly 
        355                 360                 365             


Ala Phe Val Pro Ala Gly Ala Leu Arg Ala Gly Asp Thr Leu Glu Trp 
    370                 375                 380                 


His Arg Thr Ile Ala Pro Gly Glu Gly Glu Ile Thr Ser Arg Glu Ile 
385                 390                 395                 400 


Ala Glu Ala Ala Leu Ala Gly Arg Leu Gln Ala Asp Gly Phe Val Gly 
                405                 410                 415     


Arg Tyr Ala Gly Thr Asn Ala Ser Leu Thr Ile Glu Ala Met Thr Val 
            420                 425                 430         


Pro Thr Arg Leu Tyr Asp Ala Pro Leu Pro Val Val Ala Ala Tyr Leu 
        435                 440                 445             


Arg Ser Leu Phe Gln Ala Asp Gly Tyr Val Ser Arg Arg Glu Arg Ser 
    450                 455                 460                 


Thr Leu Ile Gly Leu Asp Met Ile Ser Glu Gly Leu Ile Arg Gly Val 
465                 470                 475                 480 


Gln Gly Leu Leu Ala Arg Phe Gly Ile Phe Ala Arg Val Arg Arg Glu 
                485                 490                 495     


Ala Asp Pro Arg Pro Asp Arg His Asp Leu Trp Ser Leu Gly Ile Gln 
            500                 505                 510         


Asn Ala Gly Asp Arg Arg Thr Phe Ala Asp Glu Ile Gly Phe Leu Asp 
        515                 520                 525             


Pro Val Lys Ala Ala Lys Leu Glu Ala Ser Phe Asp Gln Pro Gly Gln 
    530                 535                 540                 


Ala Ala Lys Pro Val Lys Arg Leu Gln Ile Glu Arg Ile Glu Pro Arg 
545                 550                 555                 560 


Gly Pro Met Pro Val Tyr Asp Ile Gln Thr Asp Ser Gly Glu Tyr Leu 
                565                 570                 575     


Ser Ala Gly Leu Arg Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
            580                 585                 590         


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
        595                 600                 605             


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
    610                 615                 620                 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
625                 630                 635                 640 


Val Asn Ala Glu Ala Ala Thr Arg 
                645             


<210>  318
<211>  800
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Gob_DnaE

<400>  318

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Val Ala Gly Thr Glu Val Thr Asp Ala Glu Thr Gly 
    290                 295                 300                 


Ala Val Val Thr Val Gly Glu Leu Phe Glu Ser Arg Arg Ala Val Thr 
305                 310                 315                 320 


Val His Ala Leu Gly Ala Asp Ser Lys Leu Arg Pro Arg Pro Val Thr 
                325                 330                 335     


Asp Val Val Trp Asn Gly Arg Lys Arg Val Tyr Arg Leu Thr Thr Glu 
            340                 345                 350         


Leu Gly Lys Ser Ile Thr Ala Thr Asp Asn His Pro Phe Arg Val Leu 
        355                 360                 365             


Asp Gly Trp Lys Asn Leu Gly Glu Leu Lys Pro Gly Asp Arg Ile Ala 
    370                 375                 380                 


Ala Pro Arg Arg Leu Ala Val Pro Ser Ala Gly Thr Trp Pro Gln His 
385                 390                 395                 400 


Glu Ile Val Ala Leu Ala Gly Leu Leu Ser Glu Gly Asn Thr Cys His 
                405                 410                 415     


Pro Thr Thr Leu Tyr Phe Tyr Gly Asn Asp Arg Val Leu Ile Asp Asp 
            420                 425                 430         


Phe Ala Arg Ala Ile Gly Gln Phe Pro Asp Thr Val Ala Lys Val Tyr 
        435                 440                 445             


Ala Arg Pro Asn Arg Arg Asn Leu Glu Val Arg Ala Asn Thr Gly Arg 
    450                 455                 460                 


Asp Thr Arg Leu Lys Ser Arg Ala Glu Arg Asp Ala Ala Val Ala Leu 
465                 470                 475                 480 


Leu Ala Pro Pro Thr Arg Ser Gly Ala Phe Val Trp Ala Gln Arg Leu 
                485                 490                 495     


Gly Ile Leu Gly Lys Thr Ala Thr Glu Lys Phe Val Pro His Asp Val 
            500                 505                 510         


Phe Arg Leu Cys Asp Ser Asp Leu Glu Leu Phe Leu Gly Arg Leu Trp 
        515                 520                 525             


Ala Gly Asp Gly Phe Ile Ala Asn Asp Thr Leu Lys Val Pro Phe Tyr 
    530                 535                 540                 


Ala Thr Ser Ser Arg Arg Leu Ala Gln Asp Val Gln His Leu Leu Leu 
545                 550                 555                 560 


Arg Leu Gly Ile Val Gly Arg Ile His Glu Lys Gln Phe Lys Tyr Lys 
                565                 570                 575     


Gly Gly Leu Lys Pro Gly Phe Thr Val His Leu Ile Gly Asp Gly Ala 
            580                 585                 590         


Ala Glu Ala Phe Leu Asp Arg Ile Ala Pro His Cys Leu Gly Arg Glu 
        595                 600                 605             


His Ala Val Thr Ile Leu Arg Glu His Val Ala Thr Thr Ala Arg Gly 
    610                 615                 620                 


Leu Thr Ser Lys Asp Thr Val Pro Leu Glu Val Arg Ala Trp Val Asp 
625                 630                 635                 640 


Asp Gly Arg Arg Ala Arg Gly Leu Thr Trp Asp Glu Leu Glu Gln Gln 
                645                 650                 655     


Ser Asp Val Ser Thr Gln Glu Phe Tyr Gly Thr Pro Ala Pro Gly Lys 
            660                 665                 670         


Lys Gly Phe Arg Arg Ala Thr Ile Ala Lys Leu Ala Ala Phe Phe Gly 
        675                 680                 685             


Ser Gln Arg Leu Ala Ala Val Ala Asp Ser Asp Val Phe Trp Asp Arg 
    690                 695                 700                 


Val Val Ser Ile Glu Tyr Ala Gly Val Gln Asp Thr Tyr Asp Leu Thr 
705                 710                 715                 720 


Val Asp Glu Asp His Asn Phe Val Ala Asn Gly Leu Ile Val His Asn 
                725                 730                 735     


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
            740                 745                 750         


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
        755                 760                 765             


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
    770                 775                 780                 


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795                 800 


<210>  319
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Gob_Hyp

<400>  319

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Gln Pro Ala Gly Thr Gln Val Ala Lys Val Ile Lys Glu 
    290                 295                 300                 


Gly Arg Trp Arg Glu Asp Ser Val Ile Glu Gln Val Pro Ile Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Gly Asp Arg Val Val Ser Phe Gly Asn Ala Lys Ile Tyr 
                325                 330                 335     


Arg Arg Gly Arg Ala Val Thr Gly Ile Thr Ser Arg Arg His Thr Gly 
            340                 345                 350         


Asn Leu His Arg Val Glu Val Gly Glu Phe Arg Thr Arg Ala Thr Pro 
        355                 360                 365             


Glu His Arg Phe Thr Val Arg Phe Asp Pro Ala Arg Pro Lys Ala Gly 
    370                 375                 380                 


Leu Leu Tyr Leu Met Arg Arg Gly Asp Arg Trp Arg Val Gly Val Cys 
385                 390                 395                 400 


Gly Met Phe Asn Ser Arg Gly Phe Gly Val Ser Val Arg Leu Ser Gln 
                405                 410                 415     


Glu Arg Gly Asp Ala Ala Trp Val Leu Gly Ala Phe Ala Thr Leu Thr 
            420                 425                 430         


Glu Ala Arg Ile Ala Glu Gln Val Val Ser Cys Arg Tyr Gly Ile Pro 
        435                 440                 445             


Thr Thr Val Trp Glu Thr Gly Arg Asn Pro Gly Ala Ser Trp Ala Gln 
    450                 455                 460                 


Arg Asp Gln Ala Gly Ile Asp Ala Ile Tyr Gln Arg Leu Gly Val Asp 
465                 470                 475                 480 


Arg Ile Arg Ala Gly Val Asp Arg Leu Leu Arg Asp His Gly Leu Ser 
                485                 490                 495     


Ala Gly Leu Pro Leu Leu Ala Ala Asn Glu Pro Gly Asn Phe Ser Cys 
            500                 505                 510         


Arg Gln Ser Arg Gln Val Ala Ala Cys Asn Leu Val Pro Gly Val Met 
        515                 520                 525             


Gln Val Pro Val Pro Thr Ala Gly Glu Arg Phe Glu Trp Arg Asp Leu 
    530                 535                 540                 


Thr Ala Thr Ser Phe Glu Arg Val His Asp Leu Glu Val Trp Ser Met 
545                 550                 555                 560 


Asp Val Glu Arg Asp Lys His Tyr Val Ala Asp Gly Ile Val Val His 
                565                 570                 575     


Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
            580                 585                 590         


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
        595                 600                 605             


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
    610                 615                 620                 


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
625                 630                 635                 640 


Arg 
    


<210>  320
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Gvi_RIR1-1

<400>  320

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Ala Gly Thr Leu Leu His Thr Glu Gln Gly Tyr 
    290                 295                 300                 


Val Pro Val Glu Gln Val Val Ala Gly Val Gly Thr Arg Val Cys Thr 
305                 310                 315                 320 


His Gln Gly Phe Arg Asn Ile Ser Glu Arg Phe Asp Asn Gly Glu Ala 
                325                 330                 335     


Glu Val Phe Arg Val Thr Thr Arg Lys Gly Tyr Ser Val Glu Val Thr 
            340                 345                 350         


Ala Asn His Lys Met Ala Arg Leu Asp Glu Asn Gly Asp Leu Leu Leu 
        355                 360                 365             


Asp Glu Leu Ser His Leu Gln Val Gly Asp Asn Leu Leu Leu Leu Leu 
    370                 375                 380                 


Gly Ser Asn Pro Val Thr Glu Lys Val Arg Leu Gln Cys Ile Pro Ala 
385                 390                 395                 400 


Gly Tyr Arg Ser Ser Ile Glu Ile Ala Gln Pro Pro Glu Leu Asp Glu 
                405                 410                 415     


Gln Leu Ala Tyr Leu Leu Gly Tyr Ala Tyr Gly Asp Gly Cys Val Gly 
            420                 425                 430         


Arg Gly Ala Thr Tyr Asn Tyr Leu Ser Leu Ala Val Ser His Thr Tyr 
        435                 440                 445             


Pro Asn Val Arg Asp Gln Leu Ala Ala Ile Ile Arg Glu Lys Phe Gly 
    450                 455                 460                 


Leu Thr Thr Lys Ile Tyr Ser Gly Ser Gly Ala Val Trp Asn Leu Leu 
465                 470                 475                 480 


Val His Ser Ala Asn Leu Leu Asp Trp Leu Lys Ala Asn Gly Leu Leu 
                485                 490                 495     


Lys Gln Lys Ala Ala Asp Leu Ala Met Pro Glu Ala Ile Leu Arg Ser 
            500                 505                 510         


Pro Ser Ser Val Val Gly Ala Phe Leu Ser Gly Tyr Phe Asp Ala Asp 
        515                 520                 525             


Gly Cys Val Arg Gly Gly Lys Gly Gly Tyr Gly Phe Asp Cys Thr Ser 
    530                 535                 540                 


Lys Ala Phe Val Gly Ala Val Gln Leu Leu Leu Leu Ala Glu Gly Ile 
545                 550                 555                 560 


Val Ser Asn Leu His Thr Thr Asp Arg Ser Arg Gln Gly Trp Arg Thr 
                565                 570                 575     


Ile Tyr Arg Leu Asn Val Cys Gly Thr Glu Phe Lys Arg Arg Phe Gln 
            580                 585                 590         


Thr Leu Cys Cys Arg Ser Ala Lys Val Val His Ser Pro Met Val Leu 
        595                 600                 605             


Gly Arg Asp Gly Thr Gly Gly Tyr Pro Pro Ala Leu Val Arg Gly Ala 
    610                 615                 620                 


Ser Tyr Gln Arg Val Val Ala Val Gly Gly Lys His Leu Leu Tyr Thr 
625                 630                 635                 640 


Ala Leu Leu Lys Val Ile Glu Lys Thr Arg Thr Ala Gly Lys Gln Ala 
                645                 650                 655     


Leu Ala Glu Ser Leu Cys Gln His Val Asn Tyr Phe Pro Asp Pro Ile 
            660                 665                 670         


Val Ala Ile Glu Ser Val Gly Thr Gln Arg Val Tyr Asp Ile Glu Val 
        675                 680                 685             


Glu Gly Met His Leu Leu Gly Asn Gly Ile Tyr Thr Ser Asn Ser Thr 
    690                 695                 700                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
705                 710                 715                 720 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                725                 730                 735     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            740                 745                 750         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760                 765     


<210>  321
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hhal_DnaB-1

<400>  321

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ala Tyr Asp Ala Glu Ile Val Gln Ala Asp Gly Gly 
    290                 295                 300                 


Val Lys Thr Ile Glu Gln Ile Val Arg Glu Arg Arg Ala His Leu Ala 
305                 310                 315                 320 


Thr Val Gly Ala Asp Trp Arg Leu Thr Trp Thr Glu Pro Cys Asp Tyr 
                325                 330                 335     


Val Asp Asp Gly His Lys Pro Val Phe Glu Val Thr Thr Arg Leu Gly 
            340                 345                 350         


Arg Arg Ile Glu Thr Thr Leu Thr His Pro Phe Leu Thr Val His Gly 
        355                 360                 365             


Trp Gln Arg Leu Glu Asp Leu Ala Glu Gly Asp Ala Ile Gly Val Pro 
    370                 375                 380                 


Arg Gln Leu Pro Val Phe Gly Gln Glu Pro Ile Arg Asp Cys Glu Val 
385                 390                 395                 400 


Arg Leu Leu Gly His Leu Ile Gly Asp Gly Gly Leu Thr Gly Ser Pro 
                405                 410                 415     


Pro Arg Leu Thr Ser Gly Gln Glu Ala Met Thr Ala Asp Phe Leu Glu 
            420                 425                 430         


Ala Val Asp Ala Phe Gly Gly Val Glu Ala Lys Pro Ile Arg Ala Ser 
        435                 440                 445             


Arg Arg Thr Gln Ser Trp Val Val Val Gly Ala Ala Gln Ala Arg Ala 
    450                 455                 460                 


Ala Ala Arg Ser Ser Phe Ala Ser Leu Val Asp Ala Leu Ile Arg Arg 
465                 470                 475                 480 


Ser Pro Leu Thr Gly Arg Ala Ile Ala Arg Asn Leu Gly Val Ala Pro 
                485                 490                 495     


Ala Thr Leu Thr Tyr Trp Arg Gln Gly Val Asn Val Pro Asp Ala Ala 
            500                 505                 510         


Met Val Gly Leu Leu Ala Gly Glu Leu Gly Val Asp Val Gly Glu Leu 
        515                 520                 525             


Arg Pro Glu Pro Val Ala Arg Arg Asn Asp Arg Asn Pro Leu Gln Ala 
    530                 535                 540                 


Trp Leu Asp Arg Leu Gly Leu Ala Gly Lys Ser Ala His Glu Lys Thr 
545                 550                 555                 560 


Val Pro Asp Cys Val Phe Arg Leu Pro Arg Glu Gln Leu Ala Arg Phe 
                565                 570                 575     


Leu Asn Arg Leu Phe Ser Ser Asp Gly Trp Val Thr His Leu Ala Ser 
            580                 585                 590         


Gly Gln Gly Gln Ile Gly Tyr Thr Thr Val Ser Glu Ala Leu Ala Arg 
        595                 600                 605             


Gln Ile Gln His Leu Leu Leu Arg Phe Gly Val Leu Ala Lys Leu Arg 
    610                 615                 620                 


His Arg Ser Val Arg Tyr Gln Asp Gly Arg Arg Pro Ala Trp Gln Leu 
625                 630                 635                 640 


Asp Ile Thr His Ala Glu Ser Ile Leu Thr Phe Ala Glu Gln Ile Gly 
                645                 650                 655     


Ile Leu Gly Lys Glu Gln Arg Leu Ala Ser Val Ala Ala Ser Val Arg 
            660                 665                 670         


Gly Arg Arg Arg Gln Ser His Thr Asp His Ile Pro Cys Glu Ile Trp 
        675                 680                 685             


Gln Phe Ile Asp Arg Ala Arg Gly Glu Trp Thr Trp Ala Glu Leu Ala 
    690                 695                 700                 


Arg Arg Ala Gly Val Ala Ser Ser Asn Ile His Ala Tyr Arg Arg Gly 
705                 710                 715                 720 


Met Ser Arg Gln Arg Leu Ala Ala Phe Ala Asp Ala Leu Gly Ser Arg 
                725                 730                 735     


Glu Leu Arg Gln Leu Ala Ser Ser Asp Leu Tyr Trp Asp Arg Ile Ala 
            740                 745                 750         


Ser Ile Arg Pro Leu Gly His Lys Gln Val Tyr Asp Leu Thr Ile Pro 
        755                 760                 765             


Glu Thr His Asn Phe Ile Ala Asn Asp Val Cys Val His Asn Ser Thr 
    770                 775                 780                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
785                 790                 795                 800 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                805                 810                 815     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            820                 825                 830         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840                 845     


<210>  322
<211>  831
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hma_CDC21

<400>  322

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val His Gly Asp Thr Arg Val Thr Leu Ala Asp Gly His 
    290                 295                 300                 


Glu Arg Pro Ile Arg Glu Val Val Glu Ser Asn Leu Asp Asp Pro Lys 
305                 310                 315                 320 


Pro Val Asp Asp Gly Val Trp Asp Thr Val Asp Phe Asp Val Pro Ser 
                325                 330                 335     


Leu Gln Ser Asp Gly Thr Val Ala Thr Gln Asn Ala Thr Lys Val Trp 
            340                 345                 350         


Lys Arg Lys Ala Pro Glu Thr Leu Tyr Arg Ile Arg Thr Ala Thr Gly 
        355                 360                 365             


Arg Glu Leu Asp Val Thr Pro Ser His Pro Leu Phe Val Gln Ser Asp 
    370                 375                 380                 


Gly Arg Phe Gln Ala Arg Lys Ala Glu Glu Leu Glu Ser Gly Thr His 
385                 390                 395                 400 


Val Ala Val Pro Arg Lys Val Ser Thr Asn Ala Cys Asn Glu Leu Asp 
                405                 410                 415     


Val Thr Phe Arg Gln Ser Gln Ala His Asn Arg Ile Asp Leu Asp Leu 
            420                 425                 430         


Pro Pro Gln Trp Thr Pro Glu Leu Ala Arg Leu Ile Gly Tyr Ile Val 
        435                 440                 445             


Ala Glu Gly Tyr Val Glu Gln Arg Pro Asp Asn Thr Gly Tyr Val Ser 
    450                 455                 460                 


Ile Thr Asn Asn Asp Arg Glu Val Leu Asp Asp Ala Lys Ser Val Leu 
465                 470                 475                 480 


Glu Thr Leu Asn Leu Asn Val Thr Glu Arg Ser Ser His Glu Gly Lys 
                485                 490                 495     


Thr Ala Arg Glu Leu Leu Cys Ser Ala Gly Glu Phe Val Ser Phe Leu 
            500                 505                 510         


Ala Ser Leu Asp Glu Thr Leu Leu Gln Ser Ser Ala Glu Arg Arg Val 
        515                 520                 525             


Pro Gln Asp Ile Met Arg Ala Ser Asp Asn Val Val Thr Gly Phe Ile 
    530                 535                 540                 


Arg Gly Tyr Ile Glu Gly Glu Gly His Val Ser Thr Ser Gln Arg Glu 
545                 550                 555                 560 


Ile Thr Val Ala Ser Met Ser Lys Pro Leu Leu Glu Asp Val Arg Thr 
                565                 570                 575     


Leu Leu Val Thr Gln Gly Ile Thr Ala Gln Leu Gln Pro Arg Asn Asn 
            580                 585                 590         


Gly Ser Tyr Arg Leu Arg Ile Ser Gly Gln Ser Phe His Asp Tyr Ala 
        595                 600                 605             


Glu Gln Ile Gly Phe Ile Thr Ala Arg Lys Thr Glu Ala Cys Arg Gln 
    610                 615                 620                 


Phe Glu Gly Thr His Gly Asn Thr Asn Leu Asp Ile Val Pro Asn Leu 
625                 630                 635                 640 


Gly Pro Glu Leu Arg Arg Ile Arg Glu Ala Leu Gly Leu Thr Gln Ser 
                645                 650                 655     


Glu Cys Gly Leu Pro Arg Ser Thr Tyr Gln His Tyr Glu Arg Gly Arg 
            660                 665                 670         


Arg Asn Pro Ser Arg Asp Ser Leu Glu Ser Val Leu Asp Ala Phe Glu 
        675                 680                 685             


Thr Arg Leu Ala Glu Met Asn Asn Asp Thr Pro Ile Ser Asp Thr Ala 
    690                 695                 700                 


Arg Ser Asp Gly Gly Gly Thr Gly Ser Leu Arg Gln Asp Leu Asn Gly 
705                 710                 715                 720 


Leu Ala Ala Leu Val Glu Gly Asp Ile Ala Trp Asp Arg Ile Glu Ser 
                725                 730                 735     


Ile Glu Pro Ile Glu His Asp Glu Lys Trp Val Tyr Asp Leu Glu Ile 
            740                 745                 750         


Glu Gly Thr His Asn Tyr Leu Thr Asn Gly Val Val Ser His Asn Ser 
        755                 760                 765             


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
    770                 775                 780                 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
785                 790                 795                 800 


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
                805                 810                 815     


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            820                 825                 830     


<210>  323
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hma_TopA

<400>  323

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Ala Asp Ser Asp Val Leu Val Arg Ser Glu Asn 
    290                 295                 300                 


Gly Asp Ile Glu Arg Gln Thr Val Asp Ser Leu Phe Ser Asp Gly Gln 
305                 310                 315                 320 


Val Val Leu Ala Asp Gly Asp Thr Asp Ile Ala Val Ser Lys Glu Thr 
                325                 330                 335     


Pro Thr Val Leu Ser Leu Asp Glu Ala Thr Glu Arg Val Ser Glu Gln 
            340                 345                 350         


Glu Ser Thr Leu Val Ser Glu Arg Pro Leu Arg Asp Asp Glu Ser Val 
        355                 360                 365             


Arg Thr Ile Glu Thr Ser Arg Gly Ala Val Thr Val Thr Asp Asp His 
    370                 375                 380                 


Pro Met Tyr Ile Arg Gln Asp Gly Glu Val Thr Val Arg Pro Ala Ser 
385                 390                 395                 400 


Asp Ile Glu Ala Gly Thr Asp Leu Val Ala Ala Arg Arg Pro Pro Asp 
                405                 410                 415     


Thr Met Val Glu Pro Ser Asp Glu Thr Val Leu Ser Trp Glu Thr Phe 
            420                 425                 430         


Ala Ala Asp Cys Asp Lys His Ser Lys Leu Tyr Gly Val Asp Cys Gly 
        435                 440                 445             


Thr Glu Leu Ala Ala Gln Arg Ala Ala Arg Asp Glu Ser Gln Thr Ala 
    450                 455                 460                 


Phe Ala Glu Arg Tyr Gly Ser Tyr Gly Ser Ala Val Gly Lys Tyr Glu 
465                 470                 475                 480 


Arg Gly Glu Lys Asp Val Pro Val Trp Leu Leu Gly Glu Leu Asp Ile 
                485                 490                 495     


Arg Pro Asp Arg Ile His Gly Leu Asn Tyr Glu Thr Ser Phe Glu Asn 
            500                 505                 510         


Pro Phe Pro Leu Glu Trp Ser Pro Glu Leu Ala Gln Val Ile Gly Cys 
        515                 520                 525             


Leu Leu Gly Asp Gly Ser Ile His Arg Asn Asp Asp Glu Asn Val Val 
    530                 535                 540                 


Asp Val Arg Tyr His Asn Thr Asp Glu Ala Leu Ile Glu Arg Phe Ala 
545                 550                 555                 560 


Arg Asp Ile Glu Arg Leu Phe Asp Ile Glu Pro Thr Val Thr Asp Arg 
                565                 570                 575     


Pro Gly Arg Glu Ser His His Lys Arg Lys Tyr Gln Val Asp Val Pro 
            580                 585                 590         


Ser Ala Val Gly Arg Val Leu Val Cys Val Leu Glu Ala Val Thr Glu 
        595                 600                 605             


Asn Gly Thr Pro Gly Leu Pro Asp Ala Val Arg Pro Ala Phe Val Gly 
    610                 615                 620                 


Ala Leu Phe Asp Asp Glu Gly His Ile Ser Arg Glu Gly Lys Ala Phe 
625                 630                 635                 640 


Ile Ser Asn Thr Asp His Thr Leu Leu Thr Gly Val Gly Glu Met Leu 
                645                 650                 655     


Ala Glu Met Gly Ile Glu Thr Lys Leu Ala Pro Asp Gln His Lys Leu 
            660                 665                 670         


His Ile Arg Gly Arg Arg Asn Leu Glu Gln Phe Leu Asp Arg Ile Pro 
        675                 680                 685             


Ile Ala Ser Asp Glu Lys Phe Tyr Arg Gly Leu Asp Ala Leu Asp Ala 
    690                 695                 700                 


Tyr Asp Val Thr Thr Arg Lys Ala Glu Leu Leu Glu Ala Ile Arg Gln 
705                 710                 715                 720 


Glu Pro Lys Thr Ser Ala Ala Leu Ala Gln Thr Leu Gly Val Thr Arg 
                725                 730                 735     


Gly Ser Val Asn Lys Tyr Leu Arg Glu Leu Arg Glu Ser Gly His Ile 
            740                 745                 750         


Glu Lys Gln Ile Glu Gly Ser Asn Arg Ser Leu Asp Glu Asn Arg Thr 
        755                 760                 765             


Val Gln Tyr Val Ala Ala Asp Phe Glu Gly Ser Val Tyr Ala Thr Leu 
    770                 775                 780                 


Arg Gly Glu Pro Ser Ser Val Thr Val Glu Asp Val Glu Arg Arg Glu 
785                 790                 795                 800 


Tyr Asp Gly Pro Val Tyr Asp Leu Thr Val Ser Glu Asn Ala Pro Asn 
                805                 810                 815     


Phe Ala Val Asn Gly Gly Ala Val Val His Asn Ser Ser Thr Tyr Ala 
            820                 825                 830         


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
        835                 840                 845             


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
    850                 855                 860                 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
865                 870                 875                 880 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                885                 890         


<210>  324
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Hsa-NRC1_CDC21

<400>  324

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Arg Gly Asp Thr Thr Val Ala Leu Ala Asp Gly Ser 
    290                 295                 300                 


Glu Arg Glu Ile Arg Asp Leu Val Glu Ala Asn Leu Asp Asp Pro Arg 
305                 310                 315                 320 


Pro Val Asp Asp Gly Val Trp Asp Gly Val Asp Val Ala Val Pro Ser 
                325                 330                 335     


Leu Ala Ala Asp Gly Arg Leu Val Gln Arg Arg Ala Thr Lys Val Trp 
            340                 345                 350         


Lys Arg Glu Ala Pro Glu Thr Met Tyr Arg Val Arg Thr Ala Ala Gly 
        355                 360                 365             


His Arg Leu Thr Val Thr Pro Ser His Pro Leu Phe Val Ala Gly Ser 
    370                 375                 380                 


His Gly Pro Asp Ala Val Arg Thr Glu Asp Leu Glu Val Gly Gln Leu 
385                 390                 395                 400 


Val Gly Val Ala Pro Asp Gly Asp Gly Ser Gly Gln Val Ala Pro Asp 
                405                 410                 415     


Gly Gly Val Ile Arg Asp Ala Gln Pro Ala Pro Val Gly Asp Ala Glu 
            420                 425                 430         


Thr Val Ala Trp Ser Ala Ile Glu Ser Ile Thr Glu Val Glu Pro Asp 
        435                 440                 445             


Glu Glu Trp Val Tyr Asp Leu Glu Val Glu Gly Thr His Ser Tyr Leu 
    450                 455                 460                 


Thr Asp Gly Val Val Ser His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
465                 470                 475                 480 


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
                485                 490                 495     


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
            500                 505                 510         


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
        515                 520                 525             


Val Asn Ala Glu Ala Ala Thr Arg 
    530                 535     


<210>  325
<211>  791
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hvo_PolB

<400>  325

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Val Thr Gly Asp Arg Pro Val Val Val Arg Asp Pro Gly 
    290                 295                 300                 


Gly Thr Val Arg Ile Leu Pro Ile Glu Asp Leu Phe Ala Arg Gly Thr 
305                 310                 315                 320 


Thr Glu Ser Glu Val Leu Ile Ala Ala Asp Gly Asp Val Val Ala Ser 
                325                 330                 335     


Ala Thr Pro Gly Lys Thr Arg Arg Ala Leu Asp Gly Trp Asp Ala Leu 
            340                 345                 350         


Ser Val Asn Glu Asp Gly Glu Ala Glu Trp Gln Pro Ile Ala Gln Ala 
        355                 360                 365             


Ile Arg His Asn Thr Asp Lys Pro Val Val Asn Leu Gln His Lys Phe 
    370                 375                 380                 


Gly Glu Ser Thr Thr Thr Arg Asp His Ser Tyr Val Val Pro Gly Glu 
385                 390                 395                 400 


Asp Gly Leu Thr Thr Val Ser Pro Asp Asp Val Ala Glu Pro Tyr Arg 
                405                 410                 415     


Val Ser Gly Val Pro Asp Val Glu Pro Val Glu Gln Val Asp Val Tyr 
            420                 425                 430         


Glu Val Leu Arg Gly Tyr Glu Arg Glu Tyr Glu Asp Gly Arg Ser Val 
        435                 440                 445             


Gly Ser Asp Asn Ser Ile Thr Lys Arg Lys Gln Ile His Ala Asp Asp 
    450                 455                 460                 


Glu Tyr Val Trp Phe Gly His Glu His His Arg Asp Val Asp Ser Thr 
465                 470                 475                 480 


Val Lys Val Lys Arg Phe Val Asp Ile Asp Ser Glu Asp Gly Ala Ala 
                485                 490                 495     


Leu Ile Arg Leu Leu Gly Ala Tyr Val Pro Glu Gly Ser Ala Ser Thr 
            500                 505                 510         


Gly Glu Thr Ala Thr Ser Lys Phe Gly Ala Ser Leu Ala Glu Ser Asp 
        515                 520                 525             


Arg Glu Trp Leu Ala Gln Leu Gln Arg Asp Tyr Ser Arg Leu Phe Glu 
    530                 535                 540                 


Asn Thr Thr Ala Gly Ile Ile Thr Ser Asp Arg Arg Ala Glu Arg Thr 
545                 550                 555                 560 


Val Glu Tyr Gln Thr Asp Thr Gly Gly Ala Ser Val Thr Tyr Asn Asp 
                565                 570                 575     


Glu Thr Leu Lys Leu Gln Met Met Asn Glu Leu Ala Ala Val Phe Phe 
            580                 585                 590         


Arg Glu Phe Ala Gly Gln Thr Ser Arg Gly Lys Arg Ile Pro Ser Phe 
        595                 600                 605             


Val Phe His Leu Pro Glu Glu Lys Gln Asp Leu Phe Leu Thr Leu Leu 
    610                 615                 620                 


Val Glu Gly Asp Gly Ser Arg Glu Phe Pro Arg Tyr Thr Glu Ala Tyr 
625                 630                 635                 640 


Ala Gln Arg Asn Phe Asp Phe Glu Thr Thr Ser Arg Glu Leu Ala Ala 
                645                 650                 655     


Gly Leu Ser Met Leu Leu Thr Gln Arg Gly Gln Lys His Ser Leu Lys 
            660                 665                 670         


Tyr Arg Asp Ser Lys Asp Ser Tyr Thr Ile Arg Thr Cys Ser Thr Tyr 
        675                 680                 685             


Arg Glu Gly Arg Asp Pro Val Leu Thr Glu Ala Asp His Asp Gly Tyr 
    690                 695                 700                 


Val Tyr Asp Leu Ser Val Glu Glu Asn Glu Asn Phe Val Asp Gly Val 
705                 710                 715                 720 


Gly Gly Ile Val Leu His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
                725                 730                 735     


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
            740                 745                 750         


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
        755                 760                 765             


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
    770                 775                 780                 


Asn Ala Glu Ala Ala Thr Arg 
785                 790     


<210>  326
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_GyrB

<400>  326

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ser Gly Asp Thr Glu Ile Ala Leu Ala Ser Gly Asp 
    290                 295                 300                 


Ser Ile Thr Phe Glu Ser Leu Val Asp Ala Tyr Glu Arg Gly Glu Thr 
305                 310                 315                 320 


His Tyr Cys Tyr Thr Ile Gly Asp Asp Gly Arg Ile Arg Ile Glu Glu 
                325                 330                 335     


Ile Met Asn Pro Arg Val Thr Gln Glu Asp Ala Ala Leu Leu Ala Val 
            340                 345                 350         


Thr Leu Asp Asn Gly Glu Val Ile Arg Cys Thr Pro Asp His Glu Phe 
        355                 360                 365             


Met Leu Arg Asp Gly Asn Tyr Cys Glu Ala Gln Asn Leu Thr Asp Gly 
    370                 375                 380                 


Gln Ser Leu Met Pro Leu Tyr Arg Thr Thr Thr Glu Met Thr Glu Thr 
385                 390                 395                 400 


Thr Glu Thr Thr Glu Thr Thr Gly Thr Ala Glu Met Val Lys Gln Pro 
                405                 410                 415     


Phe Ala Gln Asn Asn Trp Glu Ser Val Ser Gln Leu Ala Asn Arg Tyr 
            420                 425                 430         


Asn Arg Arg His Thr Thr Thr Asp His Ile Val Glu Thr Gln Gln Ile 
        435                 440                 445             


Gln Ser Gln Gln Gln Ser Gln Ile Glu Thr Val Gln Ile Ser Glu Arg 
    450                 455                 460                 


Ala Asp Val His Asn His Thr Val Ile Ser Val Glu Ser Leu Thr Glu 
465                 470                 475                 480 


Thr Ala Asp Val Tyr Asp Leu Glu Val Pro Val Thr His Asn Phe Ala 
                485                 490                 495     


Leu Ala Ser Gly Val Phe Val His Asn Ser Thr Tyr Ala Ser Leu Asn 
            500                 505                 510         


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
        515                 520                 525             


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
    530                 535                 540                 


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
545                 550                 555                 560 


Leu Val Asn Ala Glu Ala Ala Thr Arg 
                565                 


<210>  327
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_MCM-1

<400>  327

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ser Gly Glu Thr Asp Ile Ala Leu Val Glu Gly Lys 
    290                 295                 300                 


Thr Ala Thr Ile Gly Glu Leu Val Glu Ser Ala Leu Thr Asp Pro Lys 
305                 310                 315                 320 


Pro Val Asp Asp Gly Val Trp Asp Thr Ala Asp Phe Thr Val Thr Ser 
                325                 330                 335     


Ala Ile Glu Thr Gly Glu Leu Ile Glu Arg Asp Val Thr Arg Val Trp 
            340                 345                 350         


Lys Arg Gln Ser Pro Glu Thr Met Arg Gln Ile Gln Ile Ala Gly Gly 
        355                 360                 365             


Arg Ser Val Thr Val Thr Pro Ser His Pro Val Phe Val Glu His Asn 
    370                 375                 380                 


Gly Ser Tyr Thr Ala Arg Arg Ala Asp Ser Leu Ser Ala Gly Glu Ser 
385                 390                 395                 400 


Val Ala Ile Ala Asp Asp Val Ala Asp Ser His Pro Ile Ser Val Asp 
                405                 410                 415     


Asn Thr Ala Asn Thr Leu Asn Pro Arg Ser Met Ser Thr Pro Gly Ile 
            420                 425                 430         


Thr Thr Asp Gly Gly Leu Tyr Arg Thr Gly Ser Asp Gly Gly Ile Val 
        435                 440                 445             


His Ala Glu Val Gly Lys Glu Asp Val Thr Asp Cys Leu Thr Thr Asp 
    450                 455                 460                 


Arg Ile Thr Ala Val Lys Thr Val Thr Pro Thr Ala Glu Trp Val Tyr 
465                 470                 475                 480 


Asp Leu Glu Val Glu Gly Thr His Ala Tyr Leu Thr Asn Gly Val Leu 
                485                 490                 495     


Ser His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            500                 505                 510         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        515                 520                 525             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    530                 535                 540                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
545                 550                 555                 560 


Ala Thr Arg 
            


<210>  328
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_MCM-4

<400>  328

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Tyr His Pro Arg Ser Glu Val Leu Leu Ala Asp Gly Gln 
    290                 295                 300                 


Arg Ile Asp Ile Gly Thr Phe Val Asp Ser Arg Ile Glu Lys Asn Asn 
305                 310                 315                 320 


Ala Asn Val Ile Asp Gly Ile Asn Cys Glu Ile Leu Pro Val Asp Asp 
                325                 330                 335     


Ile Asp Val Tyr Thr Val Asp Thr Asp Thr Gly Ser Ala Ser Thr Val 
            340                 345                 350         


Ser Ile Asp Arg Val Ser Arg His Pro Ala Pro Ser Glu Phe Ile Arg 
        355                 360                 365             


Val Lys Phe Ser Asn Gly Arg Ser Val Leu Val Thr Pro Glu His Pro 
    370                 375                 380                 


Met Phe Ile Asp Asp Gly Ser Glu Thr Lys Thr Val Gln Ala Asn Ala 
385                 390                 395                 400 


Leu Ser Gly Gly Glu Phe Val Pro Ala Pro His His Leu Pro Gly Val 
                405                 410                 415     


Asn Thr Asp Ala Ser Ser Val Ser Asp Asp Ile Asn Asp Val Ser Thr 
            420                 425                 430         


Ile Arg Thr His Val Arg Ser Arg Ala Arg Ala Lys Ala Glu Val Glu 
        435                 440                 445             


Val Arg Ala Thr Asp Gly Glu Phe Lys Leu Ile Asp Ala Ala Gln Thr 
    450                 455                 460                 


Leu Gly Ile Ile Thr Ala Val Gly Lys Val Ser Val Asp Ala Pro Glu 
465                 470                 475                 480 


Arg Gly Ile Ile Val Asp Met Asp Arg Thr Val Asp Ser Ser Lys Asp 
                485                 490                 495     


Ser Ile Asn Asn Val Leu Gly Ser Val Ile Pro Ser Asn Asp Asn Asp 
            500                 505                 510         


Ser Ile Thr Arg Val Gln Asp Thr Gly Ser Thr Gly Asn Gln Trp Arg 
        515                 520                 525             


Trp Ser Val Asn Thr Phe Ile Glu Arg Met Ile Glu Ile Ala Pro Ala 
    530                 535                 540                 


Val Thr Ala Asp Arg Pro Asn Arg Arg Val Pro Asp Ala Val Leu Gly 
545                 550                 555                 560 


Gly Ser Glu Ala Val Val Gln Gln Phe Leu Thr Gly Val Ile Ile Ala 
                565                 570                 575     


Ala Gly Arg Ile Leu Asp Glu Thr Ile Arg Ile Tyr Ala Ser Ser Asn 
            580                 585                 590         


Glu Leu Ala Cys Asp Tyr Ala Asp Ala Phe Leu Arg Leu Gly Ile Thr 
        595                 600                 605             


Ala Ser Val Glu Asp Gly Pro Ala Glu Ile Ala Ala Gln Thr Val Ile 
    610                 615                 620                 


Lys Cys Asp Ser Asp Tyr Glu Arg Ala Cys Gly Met Phe Asp Ile Ser 
625                 630                 635                 640 


Ser Ser Arg Thr Thr Pro Ser Asp Thr Ser Ser Gln Asn Asn Gln Ser 
                645                 650                 655     


Ser Val Thr Ala Gln Asn Glu Asp Thr His Gln Thr Thr Ser His Glu 
            660                 665                 670         


Ile Leu Pro Ser Gly Ile Ala Asp Glu Leu Gln Ser Ile Arg Gln Leu 
        675                 680                 685             


Leu Asn Ile Pro Ala Ser Glu Gln Leu Ala Ser Ile Thr Ala Gly Asp 
    690                 695                 700                 


Asp Gly Ile Ala Leu Ser Ile Ala Arg Ala Glu Ile Asn Leu Leu Arg 
705                 710                 715                 720 


Asp His Ile Glu Thr Leu Arg Met Asp Thr Glu Asn Val Ser Ile Gly 
                725                 730                 735     


Arg Asp Asp Cys Val Thr Pro Thr Ile Ser Ser Ser Ser Lys Tyr Lys 
            740                 745                 750         


Tyr Ala Lys Asn Ser Ile Thr Ser Asp Glu Asn Leu Gln Leu Phe Gly 
        755                 760                 765             


Gln Ser Gln Ala Gln Leu Ser Glu Arg Thr Lys Thr Thr Glu Ser Ser 
    770                 775                 780                 


Ser Ile Ser Ala Ser Thr Asp Leu Val Ser Ile Pro Ala Asn Ile Ser 
785                 790                 795                 800 


Glu Asn Arg Leu Val Ala Ala Thr Gln Arg Leu Asp Glu Val Glu Thr 
                805                 810                 815     


Arg Cys Asn Arg Arg Tyr His Arg Val Ile Ala Val Asp Thr Val Ser 
            820                 825                 830         


Asn Ala Gly Pro His Ala Cys Glu Trp Val Tyr Asp Ile Thr Val Glu 
        835                 840                 845             


Pro Thr Asn Thr Phe Ile Ser Ser Gly Val Val Leu His Asn Ser Thr 
    850                 855                 860                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
865                 870                 875                 880 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                885                 890                 895     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            900                 905                 910         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        915                 920                 925     


<210>  329
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_PolB-2

<400>  329

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Thr Pro Asp Thr Asn Val Leu Thr Pro Asn Gly Val 
    290                 295                 300                 


Arg Asn Ile Arg Asp Leu Thr Val Gly Asp Ser Val Tyr Ser Leu Asn 
305                 310                 315                 320 


Pro Glu Thr Met Gln Met Glu Ile Lys Pro Val Thr Gln Thr His Glu 
                325                 330                 335     


Tyr Pro Asp Tyr Gln Gly Asp Leu Ile Asp Ile Gln Thr Asn Glu Ile 
            340                 345                 350         


Asp Phe Arg Val Thr Pro Asn His Arg Met Leu Val Glu Ala Thr Gly 
        355                 360                 365             


Thr Asp Thr Thr Ser Thr Asn Asp Tyr Asp Phe Ile Glu Ala Gly Asn 
    370                 375                 380                 


Leu Asp Ile Ser Ser Arg Tyr Glu Leu Pro His Gly Trp Ser Val Asp 
385                 390                 395                 400 


His Thr Asp Ser Leu Gly Ala Tyr Ile Asp Leu Ile Thr Leu Leu Arg 
                405                 410                 415     


Glu Gln Ser Asp Thr Tyr Asn Val Leu Ser Asp Gly Gly Met Thr Thr 
            420                 425                 430         


Ala Ala Thr Ala Asp Ile Asn His Asn Asn Val Thr Arg Arg Val Asp 
        435                 440                 445             


Ser Asp Thr Phe Val Ser Leu Ile Gly Trp Tyr Val Ala Thr Gly Arg 
    450                 455                 460                 


Val Ser Arg Thr Gln Asn Gly Ser Asp Arg Val Tyr Leu Gln Leu Ser 
465                 470                 475                 480 


Gln Thr Asn Thr Lys Ala Arg Thr Gln Leu Thr Met Leu Leu Asp Glu 
                485                 490                 495     


Leu Gly Val Asp Trp Gln Ala Asp Asn Glu Lys Ile His Phe Val Ser 
            500                 505                 510         


His Val Trp Thr Glu Leu Phe Asp Thr Thr Cys Gly Arg Thr Glu Lys 
        515                 520                 525             


Asn Lys His Ile Pro Glu Leu Ile Phe Asp Ala Ser Ala Ser Gln Lys 
    530                 535                 540                 


Arg Ala Phe Phe Asp Ala Ile Ile Asn Gly Ser Gly Val Lys Asn Asp 
545                 550                 555                 560 


Asp Ser Tyr Gln Tyr His Thr Ser Ser Glu Asp Leu Arg Asp Asp Ile 
                565                 570                 575     


Leu Arg Leu Cys Val His Ile Gly Ile Val Ala Arg Tyr Asp Tyr Ile 
            580                 585                 590         


Asn Asp Glu Ser Trp Arg Ile Glu Cys Thr Glu Thr Ala Asn Pro Asp 
        595                 600                 605             


Phe Thr Leu Thr His Ser Gly Arg Gln Ser Thr Ala Glu Asp Gly Val 
    610                 615                 620                 


Tyr Cys Val Thr Val Ala Asp Asn Gln Thr Leu Leu Ala Gly Arg Asn 
625                 630                 635                 640 


Gly Thr Phe Gln Trp Thr Gly Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
                645                 650                 655     


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            660                 665                 670         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        675                 680                 685             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    690                 695                 700                 


Val Asn Ala Glu Ala Ala Thr Arg 
705                 710         


<210>  330
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_Pol-II-1

<400>  330

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe His Pro Glu Thr Lys Ile Trp Phe Arg Asp Thr Asp 
    290                 295                 300                 


Asn Glu Trp His His Glu Thr Ile Gln Thr Phe Val Glu Asp Arg Leu 
305                 310                 315                 320 


Asp Asp Pro Glu Ile Asp Ala Val Gly Thr Leu Val Gln Glu Val Asp 
                325                 330                 335     


Asp Asn Thr Asp Arg Glu Ile Ser Val Pro Ser Ile Asp Asp Asn Gly 
            340                 345                 350         


Asn Glu Arg Leu Gln Ser Val Thr Ala Val Ser Lys His Arg Ala Pro 
        355                 360                 365             


Asn His Leu Val Gln Ile Glu Thr Ile Ser Gly Arg Glu Ile Thr Ile 
    370                 375                 380                 


Thr Pro Asp His Glu Met His Ile Phe Glu Gln Gly Asn Leu Val Ser 
385                 390                 395                 400 


Lys Gln Ala Ser Lys Ile Thr Ser Gly Glu Tyr Ala Val Ile Pro Lys 
                405                 410                 415     


Arg Leu Gln Thr Ile Ser Pro Ser Ser His Thr Pro Gln His Asp Leu 
            420                 425                 430         


Leu Arg Glu Phe Leu Thr Arg Asp Glu Leu Thr Ala Asp Arg Leu Ile 
        435                 440                 445             


Ile His Thr Ser Asp Pro Val Arg Leu Cys Asn Arg Val Phe Pro Glu 
    450                 455                 460                 


Glu Val Thr Ser Cys Lys Asp Ala Val Glu Ile Met Gln Asn Thr Ala 
465                 470                 475                 480 


Cys His Leu Asp Lys Asn Lys Glu Thr Leu Ile Gly Trp Leu Gly Glu 
                485                 490                 495     


Gly Arg Ile Pro Val Ala Leu Leu Arg Gly Phe Val Glu Thr Asp Glu 
            500                 505                 510         


Ala Leu Leu Met Ser Ile Pro Asp Asp Val Gln Ile Gly Leu Arg Gly 
        515                 520                 525             


Glu Lys Val Arg Ile Asp Arg His Ile Gly Phe Thr Glu Glu Leu Thr 
    530                 535                 540                 


Ser Leu Leu Gly Tyr Tyr Ala Ala Ala Gly Ile Val His Thr Gln Thr 
545                 550                 555                 560 


Asn Pro Ile Ser Tyr Glu Ser Ala Gln Gln Glu Gln Ser Arg Ile Thr 
                565                 570                 575     


Phe Tyr Asn Ile Asp Thr Gln Thr Gln Thr Asp Leu Leu Asn Ala Leu 
            580                 585                 590         


Asn Ser Val Phe Glu Ile Glu Pro Ile Gln Tyr Asn Leu Asp Gly Glu 
        595                 600                 605             


Ile Leu Gly Val Pro Gly Glu Leu Ile Arg Arg Val Phe Asp Thr Val 
    610                 615                 620                 


Phe Asp Val Gly Thr Gln Pro Ser His Lys Arg Ile Pro Gln Ala Leu 
625                 630                 635                 640 


Phe Asp Ala Ser Glu Ser His Ile Thr Ser Tyr Leu Arg Cys Phe Phe 
                645                 650                 655     


Ser Thr His Asp Ser Leu Thr Thr Asp Thr Arg Asp Ile Ser Ala Thr 
            660                 665                 670         


Thr Val Ser Arg Glu Phe Lys Glu Asp Ile Ile Ala Ala Leu Arg Arg 
        675                 680                 685             


Leu Gly Ile Thr Ala Glu Val Thr Thr Gln Gln Ser Arg Ser Val Pro 
    690                 695                 700                 


Glu Val Leu Pro Asp Trp Tyr Ala Ile Asp Asp Ile Thr His His Asp 
705                 710                 715                 720 


Ala Asp Asn Ser Leu Asn Leu Thr Arg Ser Tyr Val Ile Ser Ile Ala 
                725                 730                 735     


Ser Ser Asp Ala Val Thr Leu Gln Arg Asp Arg Gln Ala Gln Glu Gln 
            740                 745                 750         


Ile Lys Tyr Asp Ala Gln Gly Leu Ile Ala Asn Asn Asn Ala Ile His 
        755                 760                 765             


Gln Ser Arg Gln Val Thr Asp Gly Gly Arg Lys Asp Tyr Ile Thr Glu 
    770                 775                 780                 


Pro Ile Thr Asp Ile Glu Tyr Val Asp Ala Asp Ile Asp Tyr Thr Tyr 
785                 790                 795                 800 


Cys Leu Thr Val Ser Glu Thr His Ser Leu Ile Val Asn Asp Leu Ser 
                805                 810                 815     


Gln Lys Gln Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            820                 825                 830         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        835                 840                 845             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    850                 855                 860                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
865                 870                 875                 880 


Ala Thr Arg 
            


<210>  331
<211>  898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_Pol-II-2

<400>  331

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Val Ala Ala Asp Ser Arg Leu Val Ala Val Ser Pro Asp 
    290                 295                 300                 


Asp Lys Ile Val Phe Thr Thr Ile Glu Asp Phe Trp Lys Lys Leu Asn 
305                 310                 315                 320 


Thr Pro Ile Glu Arg Asn Gly Lys Phe Arg Lys Arg Thr Cys Val Ser 
                325                 330                 335     


Glu Gly Trp Gln Thr Tyr Ala Phe Asp Glu Asn His Glu Ala Ser Leu 
            340                 345                 350         


Arg Pro Ile Glu Lys Ala Ile Arg Tyr Thr Ala Asp Glu Ser Glu Gln 
        355                 360                 365             


Leu Arg Arg Ile Thr Thr Gln Leu Gly Arg Ser Leu Asp Ile Thr Asp 
    370                 375                 380                 


Glu His Ser Leu Phe Arg Tyr Asp Asp Gly Ile Glu Glu Val Ala Gly 
385                 390                 395                 400 


Asp Asp Leu Thr Ala Gly Asp Ile Ile Val Ala Pro Arg Thr Leu Asp 
                405                 410                 415     


Val Glu Val Thr Gln Thr Thr Leu Asp Leu Ser Glu Tyr Ile His Asp 
            420                 425                 430         


Asn Glu Arg Cys Pro Ser Glu Gln Thr Gly Ser Gly Glu Leu Asn Leu 
        435                 440                 445             


Ala Ser Lys Ser Ala Ile Ser Asp Ser Arg Asn Lys Glu Thr Pro Gly 
    450                 455                 460                 


Val Thr His Asn Ile Leu Pro Gln Arg Ser Lys Phe Thr Asp Glu Met 
465                 470                 475                 480 


Thr Thr Leu Ser Pro Thr Ala Val Gly Gly Leu Glu Ser Glu Gln Asn 
                485                 490                 495     


Glu Thr Leu Arg Val Gly Glu Ser Thr Gly Ala Ile Glu Arg Tyr Ile 
            500                 505                 510         


Asn Val Asp Asp Ser Phe Gly Trp Leu Leu Gly Gln Phe Ile Ala Gln 
        515                 520                 525             


Arg Ser Ile Ser Thr Asp Ala Leu Thr Met Thr Val His Thr Ala Ala 
    530                 535                 540                 


Glu Lys His Ala Glu Arg Ile Val Ala Thr Ser Asp Ser Val Phe Gly 
545                 550                 555                 560 


Ile Lys Pro Thr Val Asn Ser Ile Glu Arg Gly Tyr Glu Ile Val Phe 
                565                 570                 575     


Pro Ser Val Phe Asp Thr Ile Val Ser Gly Leu Thr Ala Lys Glu Gln 
            580                 585                 590         


Ser Glu Pro Glu Gln Asp Val Asp His Thr His Thr Asp Glu Ile Gly 
        595                 600                 605             


Ile Pro Glu Cys Ile Leu His Ala Pro Asp Asp Ile Val Leu Ser Phe 
    610                 615                 620                 


Leu Gln Gly Phe Ile Leu Ala Glu Asn Ala Gln Arg Lys Gly Asn Ala 
625                 630                 635                 640 


Ala Ser Glu Ala Ser Glu Met Val Ser Glu Ser Glu Thr Thr Val Thr 
                645                 650                 655     


Leu Glu Thr Pro Ser Val Gly Val Lys Asp Gly Leu Val Phe Leu Cys 
            660                 665                 670         


His Arg Leu Gly Val Ile Thr Asp Ile Ser Glu Lys Ser Gly Glu Glu 
        675                 680                 685             


Tyr Ser Val His Phe Glu Glu Ser Arg Tyr Thr Val Ser Ile Ala Thr 
    690                 695                 700                 


Glu Gly Lys Thr Asn Pro Leu Asp Gln Ile Leu Asn Gly Glu Arg Pro 
705                 710                 715                 720 


Thr Met Pro Glu Gly Val Ser Val Pro Val Pro Asp Ala Leu Leu Thr 
                725                 730                 735     


Ile His Glu Ser Ile Ala Asn Ser Pro His Ile Asp Gln Val Ile Pro 
            740                 745                 750         


Asp Thr Val Val Gln Gln Glu Thr Val Ser Leu Glu Thr Leu Gln Ser 
        755                 760                 765             


Leu Leu Thr Gly Leu Ser Thr Val Asp Leu Pro Ala Gln Leu Glu Ala 
    770                 775                 780                 


Lys Arg Asp Glu Leu Thr Leu Leu Thr Glu Gly Asp Leu Ser Tyr Leu 
785                 790                 795                 800 


Arg Val Glu Ser Val Glu Cys Val Asp Tyr Asp Gly Tyr Leu Tyr Asp 
                805                 810                 815     


Leu Gln Val Gly Gly Glu Pro Val Phe Thr Ala Asn Trp Leu Tyr Ala 
            820                 825                 830         


His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
        835                 840                 845             


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
    850                 855                 860                 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
865                 870                 875                 880 


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
                885                 890                 895     


Thr Arg 
        


<210>  332
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_RIR1-1

<400>  332

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Ala Asp Ser Thr Val Met Leu Lys Glu Lys Gly 
    290                 295                 300                 


Met Val Ser Val Ser Glu Val Glu Thr Gly Asp Gln Ile Ala Gln Arg 
305                 310                 315                 320 


Ser Asp Thr Gly Phe Gln Tyr Lys Pro Val Glu Glu Thr His Ala Tyr 
                325                 330                 335     


Glu Asn Ala Glu Thr Leu Thr Val Thr Leu Thr Asn Gly Cys Ser Ile 
            340                 345                 350         


Arg Gly Thr Pro Asn His Arg Leu Met Val Asp Asp Glu Trp Thr Arg 
        355                 360                 365             


Ile Asp Glu Ile Gln Pro Asp Gln Glu Val His Tyr Thr Leu Gly Trp 
    370                 375                 380                 


Leu Arg Glu Thr Asn Gln Ser Pro Pro Lys Leu His Ser Gln Ser His 
385                 390                 395                 400 


Thr Thr Val Asn Gln Thr Ala Asp Ser Ile Ser Pro Asp Ser Ser Glu 
                405                 410                 415     


Pro Ile Glu Leu Ser Glu Ser Glu Asn Ala Asp Thr Gly Asn Arg His 
            420                 425                 430         


Asn Ser Ala Val Ala Val Lys Gln Ser Arg Thr Gln Thr Gln Leu Ile 
        435                 440                 445             


Ser Asp Glu Val Val Ser Arg Pro Glu His Thr Arg Arg Pro Asp Gln 
    450                 455                 460                 


Leu Ser Glu Glu Leu Ala Glu Leu Leu Gly Leu Trp Ile Asp Thr Gly 
465                 470                 475                 480 


Leu Trp His Gln Ser Gly Val Gln Phe Asn Val Glu Arg Glu Asn Ile 
                485                 490                 495     


Ala Glu Tyr Ile Asp Gln Leu Ser Gln Gln Leu Phe Asp Thr Pro Ala 
            500                 505                 510         


Ala Ile Ser Asp Thr Asp Gly Thr Tyr Thr Val Asp Ile Thr Asp His 
        515                 520                 525             


Lys Leu Lys Glu Trp Trp Lys Ala Asn Phe Gly Gly Lys Pro Asp Gly 
    530                 535                 540                 


Thr Gln Ser Ser Tyr Val Pro Gln Met Ile Lys Glu Ala Pro Thr Asn 
545                 550                 555                 560 


Val Ile Glu Ala Phe Leu Arg Gly Cys Phe Thr Ala Glu Gly Gly Leu 
                565                 570                 575     


Arg Lys Asp Met Arg Pro Arg Leu Cys Thr Ser Ser Glu Asp Ser Ile 
            580                 585                 590         


Asp Asp Ile Ala Val Leu Met Met Gly Leu Gly Tyr Pro Val Glu Lys 
        595                 600                 605             


Ser Val Ile Arg Asn Ala Asp Gly Glu Pro Tyr Tyr Ser Val Met Pro 
    610                 615                 620                 


Ala Thr Asp Asp Gly Leu Ser Ala Phe Leu His Asp Val Gly Phe Ile 
625                 630                 635                 640 


Asp Glu Arg Arg Glu Ile Gly Leu Ser Asn Ile Glu Ser Ser Asp Ser 
                645                 650                 655     


Arg Ala Leu Asn Asn Thr His Lys Ile Glu Val Glu Ser Ile Val Glu 
            660                 665                 670         


Ser Pro Pro Ala Thr Val Tyr Asp Ile Thr Val Ala Asp Asn His Glu 
        675                 680                 685             


Tyr Val Thr Asp Gly Ile Ile Ser His Asn Ser Thr Tyr Ala Ser Leu 
    690                 695                 700                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
705                 710                 715                 720 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                725                 730                 735     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            740                 745                 750         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760         


<210>  333
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_RIR1-2

<400>  333

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Glu Glu Asn Ser Leu Val Ser Thr Asp Glu Gly Leu 
    290                 295                 300                 


Arg Pro Ile Lys Asp Leu Asp Asn Thr Thr Ala Glu Phe Glu Gln Trp 
305                 310                 315                 320 


Asp Glu Ile Asp Val Gly Val Thr Thr Asp Gly Gly Thr Lys Thr Ala 
                325                 330                 335     


Thr Ala Val Tyr Asp Asn Gly Phe Ala Asn Val Arg Gln Ile Gln Thr 
            340                 345                 350         


Glu Ser Gly Phe Asn Ile Ala Ala Thr Pro Asn His Arg Phe Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Gly Thr Tyr Thr Trp Lys Glu Ala Gly Lys Phe Glu 
    370                 375                 380                 


Ser Gly Asp Arg Val Ile Leu Gln Arg Asn Thr Phe Asp Ala Gly Ser 
385                 390                 395                 400 


Arg Val Ser Leu Glu Ala Asn Glu Arg Ala Asp Asp Ala Gln Asp Thr 
                405                 410                 415     


Thr Glu Gly Pro Glu Leu Pro Gly Arg Met Thr Ser Glu Leu Ala Glu 
            420                 425                 430         


Phe Leu Gly Tyr Phe Met Gly Ser Gly Tyr Ile Ser Asp Glu Thr His 
        435                 440                 445             


Ala Ser Val Asp Leu Val Val Asp Ser Asp Ala Thr Glu Leu Asn Ser 
    450                 455                 460                 


Tyr Leu Ser Asn Leu Gly Glu Gln Leu Phe Arg Ile Thr Pro Ala Val 
465                 470                 475                 480 


Glu Ser Gln Glu Met Ser Gln Val Leu Ser Phe Arg Asp Cys His Leu 
                485                 490                 495     


Ser Arg Tyr Phe Glu Asp Asn Gly Trp Lys Lys Thr Asp Thr Gly His 
            500                 505                 510         


Asn Gly Asp Ala Ser Ala Ala Phe Val Pro Glu Gln Ile Leu Glu Gly 
        515                 520                 525             


Asp Glu Gln Val Val Asn Gly Phe Leu Arg Gly Val Phe Glu Ala Ile 
    530                 535                 540                 


Gly Thr Val Ser Glu Lys Ile Glu Ile Leu Thr Thr Ser Thr Thr Leu 
545                 550                 555                 560 


Ala Asp Gln Leu Gln Ser Leu Leu Leu Ser Leu Gly His Val Phe Thr 
                565                 570                 575     


Arg Asp Ser Thr Lys Leu Val Glu Thr Asn Asn Tyr His Asp Asp Gln 
            580                 585                 590         


Leu Arg Gln Arg Leu Cys Gly Ala Thr Arg Arg Glu Asp Glu Arg Phe 
        595                 600                 605             


Met Asn Glu Ile Gly Ser Leu Ile Glu Pro Asp Glu Leu Asn Leu Ser 
    610                 615                 620                 


Thr Arg Ala Asp Lys Asn Asp Thr Tyr Pro Ser Ser Val Ile Asp His 
625                 630                 635                 640 


Val Gln Thr Leu Asp Gly Tyr Asp Ser Val Ser Glu Ser Leu Lys Ser 
                645                 650                 655     


Arg Ile Asn Gln Ser Gln Val Asp Gly Thr Val Ser Arg Lys Leu Ile 
            660                 665                 670         


Lys Asp Ile Glu Ala Glu Thr Ala Glu Thr Val Ser Ile Ala Asp His 
        675                 680                 685             


Glu Leu Thr Gly Phe Tyr Ala Ala Thr Val Glu Ser Val Thr Glu Asp 
    690                 695                 700                 


Thr Ala Tyr Thr Lys Asp Ile Ser Val Pro Ser Asn Asn Thr Tyr Ile 
705                 710                 715                 720 


Ala Asp Gly Phe Val Thr His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
                725                 730                 735     


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            740                 745                 750         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        755                 760                 765             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    770                 775                 780                 


Val Asn Ala Glu Ala Ala Thr Arg 
785                 790         


<210>  334
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_rPol_App

<400>  334

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Ile Glu Ala Asp Glu Ser Ile Val Ile Arg Arg Asp Gly 
    290                 295                 300                 


Glu Thr Glu Leu Thr Glu Ile Gly Ser Phe Val Asp Thr Ile Leu Ala 
305                 310                 315                 320 


Ala Asp Asn Gln Glu Thr Arg Ile Thr Asp Gly His Glu Ile Ala Leu 
                325                 330                 335     


Ala Pro Asn Gly Leu Glu Val Pro Ser Leu Asp Thr Asp Glu Gln Ile 
            340                 345                 350         


Arg Trp Lys His Ile Glu Ala Val Ser Arg His Ala Ser Pro Asp Glu 
        355                 360                 365             


Ile Leu Leu Ile Glu Leu Glu Ser Gly Arg Ser Ile Arg Ala Thr Lys 
    370                 375                 380                 


Ala His Ser Phe Val Thr Arg Arg Asp Gly Asp Val Leu Pro Val Ala 
385                 390                 395                 400 


Gly Glu Thr Leu Val Val Gly Asp Val Leu Pro Thr Val Gly Ser Tyr 
                405                 410                 415     


Asp His Ala Ser Gly Ser Ile Ser Val Pro Leu Gln Ser Gln Ser Val 
            420                 425                 430         


Ala Ala Asp Gly Gly Thr Val Glu Pro Asn Thr Asn Ile Thr Ala Asn 
        435                 440                 445             


Ala Glu Arg Asp Ser Ala Ser Ile Thr Ser Ala Gly Ile Ile Gly Ser 
    450                 455                 460                 


Ala Thr Trp Glu Arg Ile Ser Ser Ile Glu Thr Val Ala Pro Glu Tyr 
465                 470                 475                 480 


Glu Tyr Val Tyr Asp Leu Ser Val Ser Gly Leu Glu Thr Phe Thr Thr 
                485                 490                 495     


Gly Glu Gly Val Val Thr His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
            500                 505                 510         


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
        515                 520                 525             


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
    530                 535                 540                 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
545                 550                 555                 560 


Val Asn Ala Glu Ala Ala Thr Arg 
                565             


<210>  335
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Kra_DnaB

<400>  335

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Ala Gly Thr Arg Val Leu Arg Ala Asp Thr Gly 
    290                 295                 300                 


Ala Glu Thr Thr Met Gly Glu Leu Phe Ala Leu Gln Ala Arg Asp Val 
305                 310                 315                 320 


Pro Val Trp Ser Leu Asp Glu Ser Leu Arg Tyr Val Arg Arg His Leu 
                325                 330                 335     


Thr Arg Val Phe Pro Thr Gly Val Lys Pro Val Phe Arg Leu Arg Thr 
            340                 345                 350         


Ala Ser Gly Lys Thr Val Arg Ala Thr Ala Asn His Pro Phe Leu Thr 
        355                 360                 365             


Tyr Asp Gly Trp Lys Pro Leu Gly Glu Leu Ser Val Ala Asp Arg Leu 
    370                 375                 380                 


Ala Val Pro Arg His Val Pro Ala Pro Glu Arg Val Ala Ser Trp Thr 
385                 390                 395                 400 


Asp Asp Gln Val Leu Leu Leu Gly His Leu Ile Gly Asp Gly Ser Phe 
                405                 410                 415     


Val Lys Arg Gln Pro Leu Arg Tyr Ala Ser Val Asp Glu Ala Asn Leu 
            420                 425                 430         


Ser Ala Val Thr Glu Ala Ala Ala Asn Ala Phe Ser Ile Val Ala Val 
        435                 440                 445             


Arg Asp Glu Tyr Ala Ala Ala Arg Cys Thr Thr Leu Arg Leu Pro Ala 
    450                 455                 460                 


Pro Tyr Arg Leu Thr His Gly Arg Arg Asn Pro Leu Ala Ala Trp Leu 
465                 470                 475                 480 


Asp Glu Leu Gly Leu Phe Gly Leu Arg Ser Tyr Glu Lys Phe Val Pro 
                485                 490                 495     


Gln Glu Val Phe His Leu Pro Lys Arg Gln Ile Ala Leu Phe Leu Arg 
            500                 505                 510         


His Leu Trp Ala Thr Asp Gly Ser Val Thr Leu Thr Arg Gln Ser Arg 
        515                 520                 525             


Gly Gly Arg Ile Tyr Tyr Ala Ser Thr Ser Leu Gln Leu Ile Gln Asp 
    530                 535                 540                 


Val Ser Arg Leu Leu Leu Arg Phe Gly Ile Ser Thr Arg Val Arg Thr 
545                 550                 555                 560 


Thr Thr Pro Lys Gly Asp His Arg Pro Gly Tyr Thr Leu Asp Val Ser 
                565                 570                 575     


Gly Val Asp Asp Gln Arg Arg Phe Leu Gln Glu Ile Gly Val His Gly 
            580                 585                 590         


Ala Arg Gly Ala Thr Ala Asp Arg Leu Leu Glu Val Ile Arg Asp Val 
        595                 600                 605             


Ser Ala Asn Thr Asn Val Asp Thr Val Pro Arg Gln Val Trp Asp Asp 
    610                 615                 620                 


Val Arg Arg Leu Leu Val Glu Lys Glu Met Thr His Arg Glu Phe Ala 
625                 630                 635                 640 


Ala Ala Met Gly Thr Ser Phe Gly Gly Ser Ser Leu Trp Lys His Ala 
                645                 650                 655     


Pro Ser Arg Glu Arg Leu Gly Arg Val Ala Gln Val Leu Asp Ser Ala 
            660                 665                 670         


Glu Leu Asp Val Leu Ala Val Asn Asp Val Leu Trp Asp Glu Val Val 
        675                 680                 685             


Ala Ile Glu Pro Asp Gly Glu Glu Gln Val Tyr Asp Ala Thr Val Leu 
    690                 695                 700                 


Gly Gly His Asn Phe Val Ala Asp Gly Ile Ala Val His Asn Ser Thr 
705                 710                 715                 720 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
                725                 730                 735     


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
            740                 745                 750         


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
        755                 760                 765             


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780         


<210>  336
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mca_RIR1

<400>  336

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Ala Asp Thr Trp Val Met Thr Ala Ser Gly Ala 
    290                 295                 300                 


Arg Gln Val Arg Asp Leu Ile Asp Arg Pro Phe Glu Ala Val Val Asp 
305                 310                 315                 320 


Gly Glu Cys His Pro Thr Glu Ser Arg Gly Phe Phe Phe Thr Gly Asp 
                325                 330                 335     


Lys Pro Val Leu Arg Leu Ser Thr Ala Glu Gly His Thr Leu Arg Leu 
            340                 345                 350         


Thr Ala Asn His Pro Val Leu Arg Val Ser Lys Met Thr Arg Gln Leu 
        355                 360                 365             


Arg Glu Thr Glu Trp Val Lys Ala Gly Glu Leu Arg Pro His Asp Lys 
    370                 375                 380                 


Ile Val Leu His Asp His Arg Ala Leu Pro Ser Trp Asp Gly Ala His 
385                 390                 395                 400 


Thr Glu Ala Glu Gly Tyr Leu Ile Gly Leu Leu Ile Gly Gly Gly Thr 
                405                 410                 415     


Leu Thr Arg Asp Lys Ala Ile Leu Ser Ile Trp Asp Ala Ala Ala Pro 
            420                 425                 430         


Lys Val Ala Asn Gly Gly Gly Ser Val Pro Ala Ala Gly Val Ala Gly 
        435                 440                 445             


Val Met Arg Ala Ala Glu Leu Ala Ala Arg Thr Leu Pro His Arg Thr 
    450                 455                 460                 


Asp Phe Asn Gly Trp Gln Thr Thr Met Glu Gly Arg Gly Glu Tyr His 
465                 470                 475                 480 


Met Ala Thr Gly Ala Leu His Thr Leu Ala Leu Glu Leu Gly Leu Thr 
                485                 490                 495     


Pro Gly Asp Lys Arg Leu Thr Ala Pro Leu Glu Thr Thr Ser Ser Ala 
            500                 505                 510         


Phe His Arg Gly Leu Leu Arg Gly Met Phe Asp Ala Asp Gly Ser Val 
        515                 520                 525             


Gln Gly Ser Gln Arg Lys Gly Val Ser Ile Arg Leu Pro Gln Thr Asp 
    530                 535                 540                 


Leu Gly Asn Leu Gln Thr Val Gln Arg Met Leu Leu Arg Leu Gly Val 
545                 550                 555                 560 


Ala Ser Thr Ile His Gln Asn Arg Arg Pro Gly Gly Thr Lys Val Leu 
                565                 570                 575     


Pro Asp Gly Glu Gly Gly Ala Lys Gly His Ser Cys Gln Ala Ala His 
            580                 585                 590         


Glu Leu Ile Ile Ser Gly Glu Asn Val Val Arg Tyr Ala Glu Arg Ile 
        595                 600                 605             


Gly Phe Ala Asp Ser Asp Lys Met Asp Arg Leu Thr Ala Leu Leu Gln 
    610                 615                 620                 


Arg Tyr Arg His Thr Arg His Ala Glu Arg Phe Ile Ala Thr Val Gln 
625                 630                 635                 640 


Ser Leu Glu Asp Asp Gly Met Glu Ala Val Tyr Asp Val Thr Val Ala 
                645                 650                 655     


Asp Val His Ala Phe Asp Ala Asn Gly Leu Tyr Val His Asn Ser Thr 
            660                 665                 670         


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
        675                 680                 685             


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
    690                 695                 700                 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
705                 710                 715                 720 


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730                 


<210>  337
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Memar_Pol-II

<400>  337

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Gly Asp Thr Glu Ile Thr Val Ser Asp Gly Arg 
    290                 295                 300                 


Arg Trp Met Ser Leu Pro Ile Arg Gln Phe Val Thr Glu Asn Phe Asp 
305                 310                 315                 320 


Ile Ser Lys Pro Gly Leu Asp His Val Gly Thr Phe Tyr Ser Asp Pro 
                325                 330                 335     


Arg Gln Pro Phe Tyr Val Arg Ser Ile Asp Ser Gln Gly Lys Thr Ser 
            340                 345                 350         


Leu Lys Arg Val Thr Ser Val Ser Val His Arg Ala Pro Ala His Leu 
        355                 360                 365             


Val Arg Phe Ala Thr Arg Arg Gly Arg Val Leu Thr Val Thr Pro Asp 
    370                 375                 380                 


His Ala Met Leu Val Trp Asp Thr Asp Tyr Leu Arg Lys Ile Lys Ala 
385                 390                 395                 400 


Leu Glu Val Ala Val Gly Asp Arg Val Pro Val Glu Glu Gly Gly Leu 
                405                 410                 415     


Val Val Ala Asp Glu Val Val Ser Arg Glu Thr Val Gln Ala Leu Asp 
            420                 425                 430         


Asp Arg Val Tyr Cys Leu Thr Val Ala Glu Asn His Thr Leu Val Ala 
        435                 440                 445             


Asn Gly Ile Phe Cys Gly Gln Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
    450                 455                 460                 


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
465                 470                 475                 480 


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
                485                 490                 495     


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
            500                 505                 510         


Asn Ala Glu Ala Ala Thr Arg 
        515                 


<210>  338
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mex_helicase

<400>  338

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Ala Gly Thr Leu Ile Lys Thr Pro Lys Gly Pro 
    290                 295                 300                 


Val Pro Ile Glu Gln Ile Gln Ser Gly Asp Leu Val Phe Asn Ala Ile 
305                 310                 315                 320 


Gly Ile Gly Val Val Glu Gly Ile Val Cys Gln Gln Lys Gln Thr Ile 
                325                 330                 335     


Thr Leu Glu Leu Ser Asp Gly Thr Ser Ile Val Cys Thr His Asp His 
            340                 345                 350         


Pro Phe Phe Cys Pro Arg Gly Trp Val Ala Ala Gly Asp Leu Glu Val 
        355                 360                 365             


Gly Ser Gly Leu Phe Ser His Glu Asp Leu Arg Arg Leu Trp Ser Gly 
    370                 375                 380                 


Gly Ala Ser Leu Gly Leu Glu Ser Gly Ser Ser Asp Gly Arg Gly Ala 
385                 390                 395                 400 


Val Arg Ser Ser Glu Val Leu Leu Arg Ile Leu Arg Glu Glu Ala Arg 
                405                 410                 415     


Glu Pro Asp Ala Gly Tyr Cys Gly Pro Ala Glu Asp Val Arg Asn Ala 
            420                 425                 430         


Ser Thr Asp Arg Ala His Ala Glu Gly Ala Trp Trp Gln Trp Gln Ala 
        435                 440                 445             


Asp Pro Ile Ala Ser Asp Glu Ala Ala Arg Ser Ala Gly Arg Arg Val 
    450                 455                 460                 


Ala Asp Arg Val Arg Asp Glu Asp Arg Arg Glu Ala Arg Pro Glu Pro 
465                 470                 475                 480 


Thr Ala Val Leu Leu Gln Asp Arg His Cys Glu Pro Leu Ala Asn Asp 
                485                 490                 495     


Arg Asn Arg Ser Gly Arg Glu His Ser Ser Arg Gly Thr Gly Glu Ala 
            500                 505                 510         


Glu Gly Gln Arg Gln Gly Asp Val Pro Cys Ser Val Arg Val Val Ser 
        515                 520                 525             


Ile Ser Arg Glu Glu Arg Gly Gly Pro Glu Ala Val Tyr Asn Leu Arg 
    530                 535                 540                 


Val Ser Gly His Pro Ser Tyr Phe Ala Gly Gly Val Leu Val His Asn 
545                 550                 555                 560 


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
                565                 570                 575     


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
            580                 585                 590         


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
        595                 600                 605             


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    610                 615                 620                 


<210>  339
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mhu_Pol-II

<400>  339

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe His Gly Asp Thr Leu Ile Glu Ile Tyr Ala Asp Gly 
    290                 295                 300                 


Ile Leu Glu Glu Ile Pro Ile Arg Arg Phe Val Leu Glu His Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Ala Gly Val Asp Ala Leu Gly Thr Phe Tyr Ala Asp Pro 
                325                 330                 335     


Val Arg Pro Ala His Val Arg Ser Val Asp Thr Gly Gly Ile Pro His 
            340                 345                 350         


Leu Arg Lys Ile Thr Ser Val Ser Val His Lys Ala Pro Ala Asn Leu 
        355                 360                 365             


Ile Gln Phe Ser Thr Ser Arg Gly Lys Asn Leu Leu Val Thr Pro Asp 
    370                 375                 380                 


His Ala Met Leu Val Trp Asp Val Ser Tyr Leu Arg Lys Ile Arg Ala 
385                 390                 395                 400 


Leu Glu Val Lys Ile Gly Asp Ala Val Pro Val Trp Glu Ser Gly Val 
                405                 410                 415     


Val Ile Ser Asp Arg Ile Val Ser Ile Asp Tyr Val Pro Cys Glu Asp 
            420                 425                 430         


Glu Arg Val Tyr Cys Leu Thr Val Asp Arg Asp His Asn Val Val Gly 
        435                 440                 445             


Asn Gly Ile Phe Thr Gly Gln Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
    450                 455                 460                 


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
465                 470                 475                 480 


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
                485                 490                 495     


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
            500                 505                 510         


Asn Ala Glu Ala Ala Thr Arg 
        515                 


<210>  340
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_GF-6P

<400>  340

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu His Pro Asp Thr Tyr Val Ile Leu Pro Asp Gly Arg 
    290                 295                 300                 


Met Lys Lys Ile Ser Glu Ile Asp Glu Asp Glu Val Leu Ser Val Asn 
305                 310                 315                 320 


Phe Glu Asp Leu Lys Leu Tyr Asn Lys Lys Ile Lys Lys Phe Lys His 
                325                 330                 335     


Lys Ala Pro Lys Ile Leu Tyr Lys Ile Lys Thr Ala Phe Ser Glu Leu 
            340                 345                 350         


Ile Thr Thr Gly Glu His Lys Leu Phe Val Val Glu Asn Gly Lys Ile 
        355                 360                 365             


Val Glu Lys Cys Val Lys Asp Leu Asn Gly Ser Glu Leu Ile Gly Val 
    370                 375                 380                 


Val Arg Lys Leu Asn Tyr Ser Phe Asn Asp Asn Val Glu Phe Lys Asp 
385                 390                 395                 400 


Val Tyr Val Glu Arg His Tyr Lys Leu Asp Glu Thr Ile Arg Asn Lys 
                405                 410                 415     


Leu Arg Lys Val Arg Glu Lys Leu Gly Leu Thr Arg Lys Asp Val Glu 
            420                 425                 430         


Lys Leu Cys Gly Val Lys Glu Ile Tyr Ile Val Lys Ile Glu Thr Gly 
        435                 440                 445             


Lys Leu Glu Ser Ile Glu Glu Glu Arg Leu Lys Lys Leu Cys Ser Leu 
    450                 455                 460                 


Tyr Gly Ile Asn Phe Glu Glu Ile Ile Tyr Arg Asp Asn Leu His Tyr 
465                 470                 475                 480 


Thr Asn Pro Val Lys Phe Pro Lys Thr Pro Thr Pro Glu Leu Met Gln 
                485                 490                 495     


Ile Ile Gly Tyr Ile Ile Gly Asp Gly His Phe Pro Ser Asn Arg Met 
            500                 505                 510         


Leu Arg Leu Lys Asp Glu Arg Lys Glu Val Leu Glu Glu Tyr Asn Gln 
        515                 520                 525             


Leu Phe Lys Thr Val Phe Asn Leu Glu Gly Asn Ile Lys Lys Gly Asp 
    530                 535                 540                 


Gly Asn Tyr Tyr Ile Leu Glu Ile Asn Ser Lys Tyr Leu Ile Asp Trp 
545                 550                 555                 560 


Phe Arg Glu Asn Ile Pro Glu Leu Phe Asn Lys Thr Gly Asn Glu Arg 
                565                 570                 575     


Thr Pro Glu Phe Val Phe Arg Leu Asn Asn Asp Leu Val Ala Ser Tyr 
            580                 585                 590         


Leu Arg Gly Ile Phe Asp Ala Glu Gly Tyr Ile Arg Ala Glu Ala Lys 
        595                 600                 605             


Gln Ile Gly Ile Gly Met Thr Ser Lys Cys Phe Ile Lys Glu Ile Gln 
    610                 615                 620                 


Phe Leu Leu Leu Arg Phe Gly Ile Leu Ala Ser Tyr Ser Lys Ile Lys 
625                 630                 635                 640 


Arg Lys Glu Glu Asn Trp Asn Asn Thr His Lys Leu Leu Ile Ser Asp 
                645                 650                 655     


Lys Lys Ser Phe Glu Leu Phe Lys Lys Tyr Ile Gly Phe Thr Ala Lys 
            660                 665                 670         


Asp Lys Met Glu Lys Leu Glu Ala Ile Leu Asn Lys Met Lys Gly Leu 
        675                 680                 685             


Asn Phe Arg Tyr Ile Ser Ile Pro Leu Thr Lys Lys Glu Ile Arg Glu 
    690                 695                 700                 


Phe Val Gly Val Pro Leu Lys Thr Ile Lys Asn Gly Asp Asn Tyr Cys 
705                 710                 715                 720 


Thr Asp Tyr Thr Ile Glu Lys Ile Ile Glu Glu Leu Asn Ser Lys Gly 
                725                 730                 735     


Leu Tyr Asp Lys Ala Glu Tyr Leu Lys Arg Phe Leu Asp Ala Asp Ile 
            740                 745                 750         


Val Trp Thr Lys Phe Lys Ile Glu Glu Val Glu Ser Asp Val Glu Tyr 
        755                 760                 765             


Val Tyr Asp Leu Glu Val Glu Asp Tyr His Asn Phe Ile Gly Asn Leu 
    770                 775                 780                 


Ile Ile Asn His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
785                 790                 795                 800 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                805                 810                 815     


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            820                 825                 830         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        835                 840                 845             


Glu Ala Ala Thr Arg 
    850             


<210>  341
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_Helicase

<400>  341

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Asn Ala Asn Thr Glu Ile Leu Gln Glu Ser Gly Phe 
    290                 295                 300                 


Arg Lys Ile Thr Glu Leu Asn Lys Asp Glu Lys Val Phe Ala Leu Cys 
305                 310                 315                 320 


Gly Lys Glu Ile Lys Pro Val Asp Gly Trp Lys Val His Lys Thr Pro 
                325                 330                 335     


Gln His Glu Tyr Asn Ile Val Val Lys Thr Val Asn Gly Leu Glu Ile 
            340                 345                 350         


Thr Thr Thr Pro Asn His Ile Phe Leu Val Lys Glu Asn Gly Ser Leu 
        355                 360                 365             


Lys Glu Lys Glu Ala Lys Asp Leu Lys Val Gly Asp Tyr Val Ala Thr 
    370                 375                 380                 


Val Asp Arg Ile Arg Val Lys Glu Lys Asp Ile Asp Leu Ser Asn Gly 
385                 390                 395                 400 


Asp Leu Tyr Phe Ile Gly Tyr Phe Ile Gly Asp Gly Tyr Thr Gly Val 
                405                 410                 415     


Ile Glu Lys Asn Thr Leu Lys Ala Thr Pro Asp Leu Ala Phe Asn Pro 
            420                 425                 430         


Lys Tyr Pro Pro Asn Phe Asp Asp Ser Glu Leu His Lys Lys Tyr Phe 
        435                 440                 445             


Leu Lys Cys Arg Ile Ser Lys Gly Val Ala His Tyr Ile Tyr Ser Lys 
    450                 455                 460                 


Lys Leu Arg Lys Ile Phe Asn Lys Leu Asn Met Leu Thr Lys Asp Asn 
465                 470                 475                 480 


Lys Asn Ile Asp Ala Phe Cys Asn Leu Pro Leu Asp Lys Leu Ala Tyr 
                485                 490                 495     


Leu Ile Ala Gly Leu Phe Asp Ser Asp Gly Tyr Ile Tyr Leu Asn Arg 
            500                 505                 510         


Lys Asn Ile Glu Phe Tyr Ser Ile Ser Glu Lys Leu Val Glu Gln Leu 
        515                 520                 525             


Gln Phe Val Leu Leu Arg Phe Gly Ile His Ser Ser Ile Arg Lys Lys 
    530                 535                 540                 


Lys Thr Lys Thr Met Val Ser Pro Thr Asn Gly Lys Glu Tyr Lys Cys 
545                 550                 555                 560 


Lys Asp Ile Tyr Val Leu Thr Ile Arg Asp Phe Met Ser Ile Lys Arg 
                565                 570                 575     


Phe Tyr Glu Asn Ile Pro Leu Arg His Glu Glu Lys Arg Arg Lys Leu 
            580                 585                 590         


Glu Glu Ile Ile Lys Asn Lys Glu Ile Gly Gln Ile Pro Ser Glu Phe 
        595                 600                 605             


Val Ala Leu Arg Phe Thr Pro Ile Ala Lys Ile Trp Cys Asp Cys Gly 
    610                 615                 620                 


Phe Ser Val Asp Leu Thr Met Phe Lys Pro Arg Thr Lys Arg Gln Arg 
625                 630                 635                 640 


Glu Leu Asn Lys Lys Arg Val Lys Leu Leu Phe Glu Leu Leu Asp Gly 
                645                 650                 655     


Lys Lys Leu Ile Thr Asn Tyr Lys Glu Tyr Tyr Ser Lys Arg Lys Asn 
            660                 665                 670         


Pro Tyr Phe Asp Phe Ile Val Arg Glu Lys Ile Asn Gly Asn Asn Tyr 
        675                 680                 685             


Tyr Ser Leu Asn Glu Lys Gly Arg Val Leu Met Ser Leu Leu Asn Lys 
    690                 695                 700                 


His Ile Lys Asp Lys Glu Asn Leu Glu Glu Met Tyr Asn Phe Leu Val 
705                 710                 715                 720 


Asn Leu Glu Lys Cys Pro Ile Cys Gly Lys Pro Ile His Lys Glu Met 
                725                 730                 735     


Arg Tyr Ser Trp Lys Lys Glu Cys Tyr Asp Gly Asp Ile Tyr Trp Asp 
            740                 745                 750         


Arg Ile Lys Glu Ile Lys Lys Ile Lys Val Asn Asp Lys Tyr Ala Tyr 
        755                 760                 765             


Asp Ile Glu Leu Pro Asp Asp Gly Ser Asn Ser His Tyr Ile Val Ala 
    770                 775                 780                 


Asn Gly Phe Ile Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
785                 790                 795                 800 


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
                805                 810                 815     


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
            820                 825                 830         


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
        835                 840                 845             


Asn Ala Glu Ala Ala Thr Arg 
    850                 855 


<210>  342
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_Hyp-1

<400>  342

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Pro Pro Asp Thr Leu Leu Ile Leu Glu Asn Gly Phe 
    290                 295                 300                 


Lys Arg Ile Val Asp Ile Lys Val Gly Asp Lys Val Leu Thr His Glu 
305                 310                 315                 320 


Asn Arg Phe Lys Lys Val Glu Lys Val Tyr Lys Arg Arg Tyr Ile Gly 
                325                 330                 335     


Asp Ile Ile Lys Ile Lys Val Arg Tyr Phe Pro Glu Glu Ile Ile Leu 
            340                 345                 350         


Thr Pro Glu His Pro Val Tyr Ala Ile Lys Thr Glu Lys Arg Cys Asp 
        355                 360                 365             


Gly Ser His Gly Ile Cys Lys Phe Asn Cys Leu Thr Gln Tyr Thr Asn 
    370                 375                 380                 


Pro Ser Cys Lys Lys Arg Tyr Arg Lys Tyr Lys Arg Glu Trp Ile Ile 
385                 390                 395                 400 


Ala Lys Asp Leu Lys Val Gly Asp Val Ile Val Tyr Pro Ile Pro Asn 
                405                 410                 415     


Arg Val Arg Asp Ile Lys Tyr Leu Ser Leu Asp Lys Tyr Leu Ser Asn 
            420                 425                 430         


Ile Lys Arg Glu Phe Cys Arg Ser Arg Ile Pro Glu Lys Ile Glu Val 
        435                 440                 445             


Ser Glu Glu Phe Cys Arg Leu Val Gly Tyr Phe Leu Ser Glu Gly Tyr 
    450                 455                 460                 


Cys Phe Arg Asp Gly Ile Gly Phe Ala Leu Gly Glu Asn Glu Lys Lys 
465                 470                 475                 480 


Ile Ile Asp Asp Ile Glu Tyr Leu Met Lys Lys Ile Phe Asn Leu Lys 
                485                 490                 495     


Pro Lys Ile Arg Asp Asp Gly Arg Ser Glu Gly Ile Glu Leu Lys Tyr 
            500                 505                 510         


Tyr Ser Arg Val Leu Arg Asp Phe Phe Gly Asp Met Phe Tyr Cys Gly 
        515                 520                 525             


Asp Glu Lys Arg Ala Trp Asn Lys Ala Leu Pro Asn Glu Phe Leu Tyr 
    530                 535                 540                 


Leu Pro Lys Asn Lys Gln Leu Gln Ile Phe Ile Gly Trp Trp Arg Gly 
545                 550                 555                 560 


Asp Lys Gly Val Thr Thr Ser Glu Ile Leu Met Asn Gln Leu Arg Leu 
                565                 570                 575     


Ile Ser Leu Arg Leu Gly Phe Ile Ile Thr Phe Ser Lys His Val Pro 
            580                 585                 590         


Lys Asn Pro Lys Ile Gly Asp Arg Glu Val Ile Lys Tyr His Ala Arg 
        595                 600                 605             


Trp Gln Gly Arg Val Ser Ile Leu Asp Glu Lys Ile Val Asp Glu Leu 
    610                 615                 620                 


Lys Asn Glu Asp Ile Lys Leu Pro Lys Lys Asp Val Arg Tyr Gly Trp 
625                 630                 635                 640 


Ile Lys Gly Asn Tyr Leu Tyr Ala Pro Ile Ile Arg Ile Gly Arg Glu 
                645                 650                 655     


Tyr Tyr Asp Gly Phe Val Tyr Asn Leu Glu Val Glu Asp Asp Ser Ser 
            660                 665                 670         


Tyr Val Thr Val Ser Gly Thr Leu His Asn Ser Thr Tyr Ala Ser Leu 
        675                 680                 685             


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
    690                 695                 700                 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
705                 710                 715                 720 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
                725                 730                 735     


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            740                 745     


<210>  343
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_IF2

<400>  343

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Met Pro His Glu Lys Val Leu Thr Glu Tyr Gly Glu 
    290                 295                 300                 


Ile Lys Ile Glu Asp Leu Phe Lys Ile Gly Lys Glu Ile Val Glu Lys 
305                 310                 315                 320 


Asp Glu Leu Lys Glu Ile Arg Lys Leu Asn Ile Lys Val His Thr Leu 
                325                 330                 335     


Asn Glu Asn Gly Glu Ile Lys Ile Ile Asn Ala Pro Tyr Val Trp Lys 
            340                 345                 350         


Leu Lys His Lys Gly Lys Met Ile Lys Val Lys Leu Lys Asn Trp His 
        355                 360                 365             


Ser Ile Thr Thr Thr Pro Glu His Pro Phe Leu Thr Asn Asn Gly Trp 
    370                 375                 380                 


Ile Lys Ala Glu Asn Ile Lys Lys Gly Met Tyr Val Ala Ile Pro Arg 
385                 390                 395                 400 


Lys Ile Tyr Gly Asn Glu Asp Phe Glu Lys Phe Ile Glu Phe Ile Asn 
                405                 410                 415     


Ser Lys Ile Leu Thr Asn Glu Leu Ile Val Lys Val Asn Glu Lys Asp 
            420                 425                 430         


Leu Lys Asn Val Glu Leu Pro Ser Thr Lys Ile Tyr Lys Lys Gln Lys 
        435                 440                 445             


Asn Val Phe Arg Ser Glu Asp Ile Ile Glu His Asn Leu Asn Ile Glu 
    450                 455                 460                 


Lys Ile Ser Phe Ser Pro Arg Ile His Arg Cys Gly Lys Pro Gln His 
465                 470                 475                 480 


Tyr Ile Lys Leu Pro Lys Ser Leu Asn Glu Trp Lys Ala Ile Phe Tyr 
                485                 490                 495     


Phe Ala Gly Val Met Phe Gly Asp Gly Cys Val Asp Arg Ile Ala Asn 
            500                 505                 510         


Asn Asp Glu Glu Val Phe Asn Lys Leu Lys Ser Leu Asn Asn Leu Gly 
        515                 520                 525             


Ile Glu Val Glu Arg Ile Lys Arg Lys Ser Ser Tyr Glu Ile Ile Phe 
    530                 535                 540                 


Lys Asn Gly Lys Asn Ala Leu Ile Asn Leu Leu Lys Ile Leu Phe Asp 
545                 550                 555                 560 


Tyr Pro Ser Glu Lys Lys Ser His Asn Ile Lys Ile Pro Gln Ile Leu 
                565                 570                 575     


Tyr Ile Ala Pro Lys Glu Leu Val Ala Glu Phe Ile Lys Gly Tyr Phe 
            580                 585                 590         


Asp Ala Asp Gly Tyr Val Asn Leu Arg Gln Asn Arg Ile Glu Val Ile 
        595                 600                 605             


Ser Ala Ser Lys Glu Phe Ile Glu Gly Leu Ser Ile Leu Leu Leu Arg 
    610                 615                 620                 


Phe Glu Ile Thr Ser Lys Ile Tyr Glu Ile Lys Lys Ser Tyr Lys Glu 
625                 630                 635                 640 


Thr Lys Lys Lys Tyr Tyr Gln Leu Asn Ile Val Gly Lys Arg Asn Leu 
                645                 650                 655     


Lys Asn Phe Lys Asn Ile Gly Phe Ser Ile Lys Tyr Lys Glu Glu Asn 
            660                 665                 670         


Leu Asn Lys Ile Ile Glu Lys Ser Arg Lys Ser Glu Lys Tyr Pro Ile 
        675                 680                 685             


Asn Lys Asp Met Lys Arg Leu Arg Ile Leu Phe Gly Met Thr Arg Asn 
    690                 695                 700                 


Glu Val Asn Val Ser Tyr Tyr Ala Lys Tyr Glu Asn Gly Lys Glu Ile 
705                 710                 715                 720 


Pro Ser Tyr Glu Ile Val Lys Lys Phe Leu Asn Ser Leu Lys Pro Lys 
                725                 730                 735     


Asn Leu Asp Lys Lys Ile Lys Val Leu Glu Gly Lys Glu Arg Asp Val 
            740                 745                 750         


Asn Tyr Leu Lys Ala Phe Glu Ser Asp Gly Leu Ile Glu Asn Gly Arg 
        755                 760                 765             


Leu Thr Lys Leu Gly Arg Glu Ala Leu Asn Ile Trp Lys Asn His Glu 
    770                 775                 780                 


Phe Gly Lys Glu Asn Ile Asp Tyr Met Lys Ser Leu Ile Glu Asn Ile 
785                 790                 795                 800 


Ala Phe Val Glu Val Glu Asp Val Glu Ile Ile Asp Tyr Asp Gly Tyr 
                805                 810                 815     


Val Tyr Asp Leu Thr Thr Glu Thr His Asn Phe Ile Ala Asn Gly Ile 
            820                 825                 830         


Val Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
        835                 840                 845             


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
    850                 855                 860                 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
865                 870                 875                 880 


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
                885                 890                 895     


Ala Ala Thr Arg 
            900 


<210>  344
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_Klba

<400>  344

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ala Leu Ala Tyr Asp Glu Pro Ile Tyr Leu Ser Asp Gly Asn 
    290                 295                 300                 


Ile Ile Asn Ile Gly Glu Phe Val Asp Lys Phe Phe Lys Lys Tyr Lys 
305                 310                 315                 320 


Asn Ser Ile Lys Lys Glu Asp Asn Gly Phe Gly Trp Ile Asp Ile Gly 
                325                 330                 335     


Asn Glu Asn Ile Tyr Ile Lys Ser Phe Asn Lys Leu Ser Leu Ile Ile 
            340                 345                 350         


Glu Asp Lys Arg Ile Leu Arg Val Trp Arg Lys Lys Tyr Ser Gly Lys 
        355                 360                 365             


Leu Ile Lys Ile Thr Thr Lys Asn Arg Arg Glu Ile Thr Leu Thr His 
    370                 375                 380                 


Asp His Pro Val Tyr Ile Ser Lys Thr Gly Glu Val Leu Glu Ile Asn 
385                 390                 395                 400 


Ala Glu Met Val Lys Val Gly Asp Tyr Ile Tyr Ile Pro Lys Asn Asn 
                405                 410                 415     


Thr Ile Asn Leu Asp Glu Val Ile Lys Val Glu Thr Val Asp Tyr Asn 
            420                 425                 430         


Gly His Ile Tyr Asp Leu Thr Val Glu Asp Asn His Thr Tyr Ile Ala 
        435                 440                 445             


Gly Lys Asn Glu Gly Phe Ala Val Ser Asn Ser Thr Tyr Ala Ser Leu 
    450                 455                 460                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
465                 470                 475                 480 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                485                 490                 495     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            500                 505                 510         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        515                 520         


<210>  345
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_PEP

<400>  345

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Ile Glu Gly Asp Ala Lys Ile Leu Thr Asp Arg Gly Phe 
    290                 295                 300                 


Leu Lys Met Lys Glu Val Tyr Lys Leu Val Lys Asn Gly Glu Lys Leu 
305                 310                 315                 320 


Lys Val Leu Gly Leu Asn Ala Glu Thr Leu Lys Thr Glu Trp Lys Glu 
                325                 330                 335     


Ile Ile Asp Ala Gln Lys Arg Glu Ala Arg Arg Tyr Glu Ile Gly Val 
            340                 345                 350         


Tyr Arg Lys Asn Lys Asn Thr Lys Asp Thr Ile Lys Ile Thr Pro Asp 
        355                 360                 365             


His Lys Phe Pro Val Phe Val Asn Gly Glu Leu Ser Lys Val Gln Leu 
    370                 375                 380                 


Cys Asp Ile Ile Asp Asn Asn Leu Ser Val Leu Ser Ile Asp Tyr Ile 
385                 390                 395                 400 


Pro Met Ile Glu Glu Lys Tyr Glu Ser Leu Ala Glu Val Met Tyr Leu 
                405                 410                 415     


Gly Gly Ala Val Leu Ser Asp Gly His Ile Val Arg Arg Asn Gly Lys 
            420                 425                 430         


Pro Ile Arg Val Arg Phe Thr Gln Lys Asp Thr Glu Glu Lys Lys Asp 
        435                 440                 445             


Phe Ile Glu Lys Val Lys Gly Asp Val Lys Leu Ile Gly Gly Asn Phe 
    450                 455                 460                 


Ile Glu Ile Ser Asn Arg Asn Asn Val Ile Glu Tyr Gln Thr Ser Arg 
465                 470                 475                 480 


Lys Ile Pro Ser Glu Ile Leu Gly Phe Ile Glu Val Asn Ile Asn Thr 
                485                 490                 495     


Ile Pro Leu Tyr Ala Thr Lys Asp Glu Ile Ala Asp Leu Ile Ala Gly 
            500                 505                 510         


Phe Val Asp Gly Asp Gly Cys Leu Ser Gly Lys Arg Arg Val Glu Ile 
        515                 520                 525             


Tyr Gln Asn Ser Ser His Ile Lys Lys Ile Glu Gly Leu Ile Val Gly 
    530                 535                 540                 


Leu Tyr Arg Leu Gly Ile Ile Pro Arg Leu Arg Tyr Lys Arg Ser Ser 
545                 550                 555                 560 


Thr Ala Thr Ile Tyr Phe Asn Asn Asn Leu Glu Thr Ile Leu Gln Arg 
                565                 570                 575     


Thr Arg Arg Ile Lys Leu Asp Lys Leu Lys Glu Phe Lys Lys Pro Val 
            580                 585                 590         


Glu Asp Lys Lys Leu Ile Asp Ile Ser Gln Ile Leu Pro Glu Leu Lys 
        595                 600                 605             


Glu Phe Asp Tyr Lys Gly Tyr Leu Tyr Lys Thr Tyr Lys Glu Lys Leu 
    610                 615                 620                 


Phe Ile Gly Ile Asn Lys Leu Glu Glu Tyr Leu Ser Lys Ile Asp Lys 
625                 630                 635                 640 


Asp Gly Ile Glu Arg Ile Lys Gln Lys Ile Lys Leu Leu Lys Glu Ser 
                645                 650                 655     


Asp Ile Tyr Ser Ile Arg Ile Lys Lys Val Gly Glu Asp Tyr Gly Glu 
            660                 665                 670         


Val Tyr Asn Ile Thr Val Lys Ala Glu Asn Glu Phe Asn His Asn Tyr 
        675                 680                 685             


Val Val Trp Thr Lys His Tyr Thr Pro Ile Val Val Phe Asn Ser Thr 
    690                 695                 700                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
705                 710                 715                 720 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                725                 730                 735     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            740                 745                 750         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760                 765     


<210>  346
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_Pol-1

<400>  346

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys His Pro Lys Gly Thr Lys Val Val Val Lys Gly Lys Gly 
    290                 295                 300                 


Ile Val Asn Ile Glu Asp Val Lys Glu Gly Asn Tyr Val Leu Gly Ile 
305                 310                 315                 320 


Asp Gly Trp Gln Lys Val Lys Lys Val Trp Lys Tyr Glu Tyr Glu Gly 
                325                 330                 335     


Glu Leu Ile Asn Val Asn Gly Leu Lys Cys Thr Pro Asn His Lys Ile 
            340                 345                 350         


Pro Leu Arg Tyr Lys Ile Lys His Lys Lys Ile Asn Lys Asn Asp Tyr 
        355                 360                 365             


Leu Val Arg Asp Ile Tyr Ala Lys Ser Leu Leu Thr Lys Phe Lys Gly 
    370                 375                 380                 


Glu Gly Lys Leu Ile Leu Cys Lys Asp Phe Glu Thr Ile Gly Asn Tyr 
385                 390                 395                 400 


Glu Lys Tyr Ile Asn Asp Met Asp Glu Asp Phe Ile Leu Lys Ser Glu 
                405                 410                 415     


Leu Ile Gly Ile Leu Leu Ala Glu Gly His Leu Leu Arg Arg Asp Ile 
            420                 425                 430         


Glu Tyr Phe Asp Ser Ser Arg Gly Lys Lys Arg Ile Ser His Gln Tyr 
        435                 440                 445             


Arg Val Glu Ile Thr Val Asn Glu Asp Glu Lys Asp Phe Ile Glu Lys 
    450                 455                 460                 


Ile Lys Tyr Ile Phe Lys Lys Leu Phe Asn Tyr Glu Leu Tyr Val Arg 
465                 470                 475                 480 


Arg Lys Lys Gly Thr Lys Ala Ile Thr Leu Gly Cys Ala Lys Lys Asp 
                485                 490                 495     


Ile Tyr Leu Lys Ile Glu Glu Ile Leu Lys Asn Lys Glu Lys Tyr Leu 
            500                 505                 510         


Pro Asn Ala Ile Leu Arg Gly Phe Phe Glu Gly Asp Gly Tyr Val Asn 
        515                 520                 525             


Thr Val Arg Arg Ala Val Val Val Asn Gln Gly Thr Asn Asn Tyr Asp 
    530                 535                 540                 


Lys Ile Lys Phe Ile Ala Ser Leu Leu Asp Arg Leu Gly Ile Lys Tyr 
545                 550                 555                 560 


Ser Phe Tyr Thr Tyr Ser Tyr Glu Glu Arg Gly Lys Lys Leu Lys Arg 
                565                 570                 575     


Tyr Val Ile Glu Ile Phe Ser Lys Gly Asp Leu Ile Lys Phe Ser Ile 
            580                 585                 590         


Leu Ile Ser Phe Ile Ser Arg Arg Lys Asn Asn Leu Leu Asn Glu Ile 
        595                 600                 605             


Ile Arg Gln Lys Thr Leu Tyr Lys Ile Gly Asp Tyr Gly Phe Tyr Asp 
    610                 615                 620                 


Leu Asp Asp Val Cys Val Ser Leu Glu Ser Tyr Lys Gly Glu Val Tyr 
625                 630                 635                 640 


Asp Leu Thr Leu Glu Gly Arg Pro Tyr Tyr Phe Ala Asn Gly Ile Leu 
                645                 650                 655     


Thr His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            660                 665                 670         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        675                 680                 685             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    690                 695                 700                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
705                 710                 715                 720 


Ala Thr Arg 
            


<210>  347
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_Pol-2

<400>  347

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Ile Leu Pro Asp Glu Tyr Leu Thr Ile Ile Glu Glu Asp 
    290                 295                 300                 


Gly Ile Lys Val Val Lys Ile Gly Glu Tyr Ile Asp Asp Leu Met Arg 
305                 310                 315                 320 


Lys His Lys Asp Lys Ile Lys Phe Ser Gly Ile Ser Glu Ile Leu Glu 
                325                 330                 335     


Thr Lys Asn Leu Lys Thr Phe Ser Phe Asp Lys Ile Thr Lys Lys Cys 
            340                 345                 350         


Glu Ile Lys Lys Val Lys Ala Leu Ile Arg His Pro Tyr Phe Gly Lys 
        355                 360                 365             


Ala Tyr Lys Ile Lys Leu Arg Ser Gly Arg Thr Ile Lys Val Thr Arg 
    370                 375                 380                 


Gly His Ser Leu Phe Lys Tyr Glu Asn Gly Lys Ile Val Glu Val Lys 
385                 390                 395                 400 


Gly Asp Asp Val Arg Phe Gly Asp Leu Ile Val Val Pro Lys Lys Leu 
                405                 410                 415     


Thr Cys Val Asp Lys Glu Val Val Ile Asn Ile Pro Lys Arg Leu Ile 
            420                 425                 430         


Asn Ala Asp Glu Glu Glu Ile Lys Asp Leu Val Ile Thr Lys His Lys 
        435                 440                 445             


Asp Lys Ala Phe Phe Val Lys Leu Lys Lys Thr Leu Glu Asp Ile Glu 
    450                 455                 460                 


Asn Asn Lys Leu Lys Val Ile Phe Asp Asp Cys Ile Leu Tyr Leu Lys 
465                 470                 475                 480 


Glu Leu Gly Leu Ile Asp Tyr Asn Ile Ile Lys Lys Ile Asn Lys Val 
                485                 490                 495     


Asp Ile Lys Ile Leu Asp Glu Glu Lys Phe Lys Ala Tyr Lys Lys Tyr 
            500                 505                 510         


Phe Asp Thr Val Ile Glu His Gly Asn Phe Lys Lys Gly Arg Cys Asn 
        515                 520                 525             


Ile Gln Tyr Ile Lys Ile Lys Asp Tyr Ile Ala Asn Ile Pro Asp Lys 
    530                 535                 540                 


Glu Phe Glu Asp Cys Glu Ile Gly Ala Tyr Ser Gly Lys Ile Asn Ala 
545                 550                 555                 560 


Leu Leu Lys Leu Asp Glu Lys Leu Ala Lys Phe Leu Gly Phe Phe Val 
                565                 570                 575     


Thr Arg Gly Arg Leu Lys Lys Gln Lys Leu Lys Gly Glu Thr Val Tyr 
            580                 585                 590         


Glu Ile Ser Val Tyr Lys Ser Leu Pro Glu Tyr Gln Lys Glu Ile Ala 
        595                 600                 605             


Glu Thr Phe Lys Glu Val Phe Gly Ala Gly Ser Met Val Lys Asp Lys 
    610                 615                 620                 


Val Thr Met Asp Asn Lys Ile Val Tyr Leu Val Leu Lys Tyr Ile Phe 
625                 630                 635                 640 


Lys Cys Gly Asp Lys Asp Lys Lys His Ile Pro Glu Glu Leu Phe Leu 
                645                 650                 655     


Ala Ser Glu Ser Val Ile Lys Ser Phe Leu Asp Gly Phe Leu Lys Ala 
            660                 665                 670         


Lys Lys Asn Ser His Lys Gly Thr Ser Thr Phe Met Ala Lys Asp Glu 
        675                 680                 685             


Lys Tyr Leu Asn Gln Leu Met Ile Leu Phe Asn Leu Val Gly Ile Pro 
    690                 695                 700                 


Thr Arg Phe Thr Pro Val Lys Asn Lys Gly Tyr Lys Leu Thr Leu Asn 
705                 710                 715                 720 


Pro Lys Tyr Gly Thr Val Lys Asp Leu Met Leu Asp Glu Val Lys Glu 
                725                 730                 735     


Ile Glu Ala Phe Glu Tyr Ser Gly Tyr Val Tyr Asp Leu Ser Val Glu 
            740                 745                 750         


Asp Asn Glu Asn Phe Leu Val Asn Asn Ile Tyr Ala His Asn Ser Thr 
        755                 760                 765             


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
    770                 775                 780                 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
785                 790                 795                 800 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
                805                 810                 815     


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            820                 825                 830 


<210>  348
<211>  902
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_RFC-1

<400>  348

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Gly Asp Thr Lys Val Ile Val Asn Gly Glu Ile 
    290                 295                 300                 


Arg Glu Ile Gly Glu Val Ile Glu Glu Ile Ser Asn Gly Lys Phe Gly 
305                 310                 315                 320 


Val Thr Leu Thr Asn Asn Leu Lys Val Leu Gly Ile Asp Glu Asp Gly 
                325                 330                 335     


Lys Ile Arg Glu Phe Asp Val Gln Tyr Val Tyr Lys Asp Lys Thr Asn 
            340                 345                 350         


Thr Leu Ile Lys Ile Lys Thr Lys Met Gly Arg Glu Leu Lys Val Thr 
        355                 360                 365             


Thr Tyr His Pro Leu Leu Ile Asn His Lys Asn Gly Glu Ile Lys Trp 
    370                 375                 380                 


Glu Lys Ala Glu Asn Leu Lys Val Gly Asp Lys Leu Ala Thr Pro Arg 
385                 390                 395                 400 


Tyr Ile Leu Phe Asn Glu Ser Asp Tyr Asn Glu Glu Leu Ala Glu Trp 
                405                 410                 415     


Leu Gly Tyr Phe Ile Gly Asp Gly His Ala Asp Lys Glu Ser Asn Lys 
            420                 425                 430         


Ile Thr Phe Thr Asn Gly Asp Glu Lys Leu Arg Lys Arg Phe Ala Glu 
        435                 440                 445             


Leu Thr Glu Lys Leu Phe Lys Asp Ala Lys Ile Lys Glu Arg Ile His 
    450                 455                 460                 


Lys Asp Arg Thr Pro Asp Ile Tyr Val Asn Ser Lys Glu Ala Val Glu 
465                 470                 475                 480 


Phe Ile Asp Lys Leu Gly Leu Arg Gly Lys Lys Ala Asp Lys Val Arg 
                485                 490                 495     


Ile Pro Lys Glu Ile Met Arg Ser Asp Ala Leu Arg Ala Phe Leu Arg 
            500                 505                 510         


Ala Tyr Phe Asp Cys Asp Gly Gly Ile Glu Lys His Ser Ile Val Leu 
        515                 520                 525             


Ser Thr Ala Ser Lys Glu Met Ala Glu Asp Leu Val Tyr Ala Leu Leu 
    530                 535                 540                 


Arg Phe Gly Ile Ile Ala Lys Leu Arg Glu Lys Val Asn Lys Asn Asn 
545                 550                 555                 560 


Asn Lys Val Tyr Tyr His Ile Val Ile Ser Asn Ser Ser Asn Leu Arg 
                565                 570                 575     


Thr Phe Leu Asp Asn Ile Gly Phe Ser Gln Glu Arg Lys Leu Lys Lys 
            580                 585                 590         


Leu Leu Glu Ile Ile Lys Asp Glu Asn Pro Asn Leu Asp Val Ile Thr 
        595                 600                 605             


Ile Asp Lys Glu Lys Ile Arg Tyr Ile Arg Asp Arg Leu Lys Val Lys 
    610                 615                 620                 


Leu Thr Arg Asp Ile Glu Lys Asp Asn Trp Ser Tyr Asn Lys Cys Arg 
625                 630                 635                 640 


Lys Ile Thr Gln Glu Leu Leu Lys Glu Ile Tyr Tyr Arg Leu Glu Glu 
                645                 650                 655     


Leu Lys Glu Ile Glu Lys Ala Leu Glu Glu Asn Ile Leu Ile Asp Trp 
            660                 665                 670         


Asp Glu Val Ala Glu Arg Arg Lys Glu Ile Ala Glu Lys Thr Gly Ile 
        675                 680                 685             


Arg Ser Asp Arg Ile Leu Glu Tyr Ile Arg Gly Lys Arg Lys Pro Ser 
    690                 695                 700                 


Leu Lys Asn Tyr Ile Lys Ile Ala Asn Thr Leu Gly Lys Asn Ile Glu 
705                 710                 715                 720 


Lys Ile Ile Asp Ala Met Arg Ile Phe Ala Lys Lys Tyr Ser Ser Tyr 
                725                 730                 735     


Ala Glu Ile Gly Lys Met Leu Asn Met Trp Asn Ser Ser Ile Lys Ile 
            740                 745                 750         


Tyr Leu Glu Ser Asn Thr Gln Glu Ile Glu Lys Leu Glu Glu Ile Arg 
        755                 760                 765             


Lys Thr Glu Leu Lys Leu Val Lys Glu Ile Leu Asn Asp Glu Lys Leu 
    770                 775                 780                 


Ile Asp Ser Ile Gly Tyr Val Leu Phe Leu Ala Ser Asn Glu Ile Tyr 
785                 790                 795                 800 


Trp Asp Glu Ile Val Glu Ile Glu Gln Leu Asn Gly Glu Phe Thr Ile 
                805                 810                 815     


Tyr Asp Leu His Val Pro Arg Tyr His Asn Phe Ile Gly Gly Asn Leu 
            820                 825                 830         


Pro Thr Ile Leu His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
        835                 840                 845             


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
    850                 855                 860                 


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
865                 870                 875                 880 


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
                885                 890                 895     


Ala Glu Ala Ala Thr Arg 
            900         


<210>  349
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_RFC-2

<400>  349

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Val Ser Lys Asp Thr Pro Ile Leu Val Lys Ile Asp Gly 
    290                 295                 300                 


Lys Val Lys Arg Thr Thr Phe Glu Glu Leu Asp Lys Ile Tyr Phe Glu 
305                 310                 315                 320 


Thr Asn Asp Glu Asn Glu Met Tyr Lys Lys Val Asp Asn Leu Glu Val 
                325                 330                 335     


Leu Thr Val Asp Glu Asn Phe Arg Val Arg Trp Arg Lys Val Ser Thr 
            340                 345                 350         


Ile Ile Arg His Lys Val Asp Lys Ile Leu Arg Ile Lys Phe Glu Gly 
        355                 360                 365             


Gly Tyr Ile Glu Leu Thr Gly Asn His Ser Ile Met Met Leu Asp Glu 
    370                 375                 380                 


Asn Gly Leu Val Ala Lys Lys Ala Ser Asp Ile Lys Val Gly Asp Cys 
385                 390                 395                 400 


Phe Leu Ser Phe Val Ala Asn Ile Glu Gly Glu Lys Asp Arg Leu Asp 
                405                 410                 415     


Leu Lys Glu Phe Glu Pro Lys Asp Ile Thr Ser Arg Val Lys Ile Ile 
            420                 425                 430         


Asn Asp Phe Asp Ile Asp Glu Asp Thr Ala Trp Met Leu Gly Leu Tyr 
        435                 440                 445             


Val Ala Glu Gly Ala Val Gly Phe Lys Gly Lys Thr Ser Gly Gln Val 
    450                 455                 460                 


Ile Tyr Thr Leu Gly Ser His Glu His Asp Leu Ile Asn Lys Leu Asn 
465                 470                 475                 480 


Asp Ile Val Asp Lys Lys Gly Phe Ser Lys Tyr Glu Asn Phe Thr Gly 
                485                 490                 495     


Ser Gly Phe Asp Arg Lys Arg Leu Ser Ala Lys Gln Ile Arg Ile Leu 
            500                 505                 510         


Asn Thr Gln Leu Ala Arg Phe Val Glu Glu Asn Phe Tyr Asp Gly Asn 
        515                 520                 525             


Gly Arg Arg Ala Arg Asn Lys Arg Ile Pro Asp Ile Ile Phe Glu Leu 
    530                 535                 540                 


Lys Glu Asn Leu Arg Val Glu Phe Leu Lys Gly Leu Ala Asp Gly Asp 
545                 550                 555                 560 


Ser Ser Gly Asn Trp Arg Glu Val Val Arg Ile Ser Ser Lys Ser Asp 
                565                 570                 575     


Asn Leu Leu Ile Asp Thr Val Trp Leu Ala Arg Ile Ser Gly Ile Glu 
            580                 585                 590         


Ser Ser Ile Phe Glu Asn Glu Ala Arg Leu Ile Trp Lys Gly Gly Met 
        595                 600                 605             


Lys Trp Lys Lys Ser Asn Leu Leu Pro Ala Glu Pro Ile Ile Lys Met 
    610                 615                 620                 


Ile Lys Lys Leu Glu Asn Lys Ile Asn Gly Asn Trp Arg Tyr Ile Leu 
625                 630                 635                 640 


Arg His Gln Leu Tyr Glu Gly Lys Lys Arg Val Ser Lys Asp Lys Ile 
                645                 650                 655     


Lys Gln Ile Leu Glu Met Val Asn Val Glu Lys Leu Ser Asp Lys Glu 
            660                 665                 670         


Lys Glu Val Tyr Asp Leu Leu Lys Lys Leu Ser Lys Thr Glu Leu Tyr 
        675                 680                 685             


Ala Leu Val Val Lys Glu Ile Glu Ile Ile Asp Tyr Asn Asp Phe Val 
    690                 695                 700                 


Tyr Asp Val Ser Val Pro Asn Asn Glu Met Phe Phe Ala Gly Asn Val 
705                 710                 715                 720 


Pro Ile Leu Leu His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
                725                 730                 735     


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
            740                 745                 750         


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
        755                 760                 765             


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
    770                 775                 780                 


Ala Glu Ala Ala Thr Arg 
785                 790 


<210>  350
<211>  897
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_RFC-3

<400>  350

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Gly Asp Ala Lys Ile Thr Leu Pro Asp Glu Arg 
    290                 295                 300                 


Glu Ile Lys Ile Glu Asp Phe Ile Lys Met Phe Glu Glu Arg Lys Leu 
305                 310                 315                 320 


Lys His Val Leu Asn Arg Asn Gly Glu Asp Leu Val Leu Ala Gly Val 
                325                 330                 335     


Lys Phe Asn Ser Lys Ile Val Asn His Lys Val Tyr Arg Leu Val Leu 
            340                 345                 350         


Glu Ser Gly Arg Glu Ile Glu Ala Thr Gly Asp His Lys Phe Leu Thr 
        355                 360                 365             


Arg Asp Gly Trp Lys Glu Val Tyr Glu Leu Lys Glu Asp Asp Glu Val 
    370                 375                 380                 


Leu Val Tyr Pro Ala Leu Glu Gly Val Gly Phe Glu Val Asp Glu Arg 
385                 390                 395                 400 


Arg Ile Ile Gly Leu Asn Glu Phe Tyr Glu Phe Leu Thr Asn Tyr Glu 
                405                 410                 415     


Ile Lys Leu Gly Tyr Lys Pro Leu Gly Lys Ala Lys Ser Tyr Lys Glu 
            420                 425                 430         


Leu Ile Thr Arg Asp Lys Glu Lys Ile Leu Ser Arg Val Leu Glu Leu 
        435                 440                 445             


Ser Asp Lys Tyr Ser Lys Ser Glu Ile Arg Arg Lys Ile Glu Glu Glu 
    450                 455                 460                 


Phe Gly Ile Lys Ile Ser Leu Thr Thr Ile Lys Asn Leu Ile Asn Gly 
465                 470                 475                 480 


Lys Ile Asp Gly Phe Ala Leu Lys Tyr Val Arg Lys Ile Lys Glu Leu 
                485                 490                 495     


Gly Trp Asp Glu Ile Thr Tyr Asp Asp Glu Lys Ala Gly Ile Phe Ala 
            500                 505                 510         


Arg Leu Leu Gly Phe Ile Ile Gly Asp Gly His Leu Ser Lys Ser Lys 
        515                 520                 525             


Glu Gly Arg Ile Leu Ile Thr Ala Thr Ile Asn Glu Leu Glu Gly Ile 
    530                 535                 540                 


Lys Lys Asp Leu Glu Lys Leu Gly Ile Lys Ala Ser Asn Ile Ile Glu 
545                 550                 555                 560 


Lys Asp Ile Glu His Lys Leu Asp Gly Arg Glu Ile Lys Gly Lys Thr 
                565                 570                 575     


Ser Phe Ile Tyr Ile Asn Asn Lys Ala Phe Tyr Leu Leu Leu Asn Phe 
            580                 585                 590         


Trp Gly Val Glu Ile Gly Asn Lys Thr Ile Asn Gly Tyr Asn Ile Pro 
        595                 600                 605             


Lys Trp Ile Lys Tyr Gly Asn Lys Phe Val Lys Arg Glu Phe Leu Arg 
    610                 615                 620                 


Gly Leu Phe Gly Ala Asp Gly Thr Lys Pro Tyr Ile Lys Lys Tyr Asn 
625                 630                 635                 640 


Ile Asn Gly Ile Lys Leu Gly Ile Arg Val Glu Asn Ile Ser Lys Asp 
                645                 650                 655     


Lys Thr Leu Glu Phe Phe Glu Glu Val Lys Lys Met Leu Glu Glu Phe 
            660                 665                 670         


Glu Val Glu Ser Tyr Ile Lys Val Ser Lys Ile Asp Asn Lys Asn Leu 
        675                 680                 685             


Thr Glu Leu Ile Val Lys Ala Asn Asn Lys Asn Tyr Leu Lys Tyr Leu 
    690                 695                 700                 


Ser Arg Ile Ser Tyr Ala Tyr Glu Lys Asp Asn Phe Ala Arg Leu Val 
705                 710                 715                 720 


Gly Glu Tyr Leu Arg Ile Lys Glu Ala Tyr Lys Asp Ile Ile Leu Lys 
                725                 730                 735     


Glu Ile Ala Glu Asn Ala Leu Lys Glu Ala Asp Gly Glu Lys Ser Leu 
            740                 745                 750         


Arg Glu Leu Ala Arg Lys Tyr Asn Val Pro Val Asp Phe Ile Ile Asn 
        755                 760                 765             


Gln Leu Lys Gly Lys Asp Ile Gly Leu Pro Arg Asn Phe Met Thr Phe 
    770                 775                 780                 


Glu Glu Phe Leu Lys Glu Lys Val Val Asp Gly Lys Tyr Val Ser Glu 
785                 790                 795                 800 


Arg Ile Ile Lys Lys Glu Cys Ile Gly Tyr Arg Asp Val Tyr Asp Ile 
                805                 810                 815     


Thr Cys His Lys Asp Pro Ser Phe Ile Ala Asn Gly Phe Val Ser His 
            820                 825                 830         


Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
        835                 840                 845             


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
    850                 855                 860                 


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
865                 870                 875                 880 


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
                885                 890                 895     


Arg 
    


<210>  351
<211>  848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_r-Gyr

<400>  351

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Pro Asp Thr Tyr Val Val Leu Gly Asp Gly Arg 
    290                 295                 300                 


Ile Glu Thr Ile Glu Asp Ile Val Asn Ala Lys Glu Arg Asn Val Leu 
305                 310                 315                 320 


Ser Leu Asp Leu Asp Asn Leu Ser Ile Lys Ile Asp Thr Ala Ile Lys 
                325                 330                 335     


Phe Trp Lys Leu Arg Tyr Asn Gly Asn Leu Ser Lys Ile Thr Leu Ser 
            340                 345                 350         


Asn Asn Tyr Glu Leu Lys Ala Thr Pro Asp His Cys Leu Leu Val Leu 
        355                 360                 365             


Arg Asp Asn Gln Leu Lys Trp Ile Pro Ala Lys Asp Ile Lys Glu Asn 
    370                 375                 380                 


Asp Tyr Ile Ala Met Pro Phe Asn Tyr Lys Val Glu Arg Lys Pro Ile 
385                 390                 395                 400 


Ser Leu Leu Asn Leu Leu Lys Tyr Leu Asp Ile Thr Asp Val Leu Ile 
                405                 410                 415     


Glu Phe Asp Glu Asn Ser Thr Ile Phe Glu Lys Ile Ala Glu Tyr Ile 
            420                 425                 430         


Arg Asn Asn Ile Lys Thr Ser Thr Lys Tyr Lys Tyr Leu Arg Asn Arg 
        435                 440                 445             


Arg Val Pro Leu Lys Tyr Leu Ile Glu Trp Asn Phe Asp Leu Asp Glu 
    450                 455                 460                 


Ile Glu Lys Glu Ala Lys Tyr Ile Tyr Lys Ser Val Ala Gly Thr Lys 
465                 470                 475                 480 


Lys Ile Pro Leu Phe Lys Leu Asp Glu Arg Phe Trp Tyr Phe Ala Gly 
                485                 490                 495     


Leu Val Leu Gly Asp Gly Ser Ile Gln Asp Ser Lys Ile Arg Ile Ala 
            500                 505                 510         


Gln Thr Pro Leu Lys Asp Val Lys Ser Ile Leu Asp Glu Thr Phe Pro 
        515                 520                 525             


Phe Leu His Asn Trp Ile Ser Gly Asn Gln Val Ile Ile Ser Asn Pro 
    530                 535                 540                 


Ile Ile Ala Glu Ile Leu Glu Lys Leu Gly Met Arg Asn Gly Lys Leu 
545                 550                 555                 560 


Asn Gly Ile Ile Phe Ser Leu Pro Glu Ser Tyr Ile Asn Ala Leu Ile 
                565                 570                 575     


Ala Gly Tyr Phe Asp Thr Asp Gly Cys Phe Ser Leu Leu Tyr Asp Lys 
            580                 585                 590         


Lys Ala Lys Lys His Asn Leu Arg Met Val Leu Thr Ser Lys Arg Arg 
        595                 600                 605             


Asp Val Leu Glu Lys Ile Gly Ile Tyr Leu Asn Ser Ile Gly Ile Leu 
    610                 615                 620                 


Asn Thr Leu His Lys Ser Arg Glu Val Tyr Ser Leu Ile Ile Ser Asn 
625                 630                 635                 640 


Lys Ser Leu Glu Thr Phe Lys Glu Lys Ile Ala Lys Tyr Leu Lys Ile 
                645                 650                 655     


Arg Lys Glu Ala Phe Ile Asn Gly Tyr Lys Thr Tyr Lys Lys Glu His 
            660                 665                 670         


Glu Glu Arg Phe Glu Cys Asp Leu Leu Pro Val Lys Glu Val Phe Lys 
        675                 680                 685             


Lys Leu Thr Phe Glu Lys Gly Arg Lys Glu Ile Leu Lys Asp Ser Lys 
    690                 695                 700                 


Ile His Ile Glu Asn Trp Tyr Lys Glu Lys Thr Asn Asn Ile Pro Arg 
705                 710                 715                 720 


Glu Lys Leu Lys Thr Val Leu Arg Tyr Ala Asn Asn Ser Glu His Lys 
                725                 730                 735     


Glu Phe Leu Glu Lys Ile Val Asn Gly Asp Ile Ser Phe Val Arg Val 
            740                 745                 750         


Lys Lys Val Glu Asn Ile Pro Tyr Asp Gly Tyr Val Tyr Asp Leu Ser 
        755                 760                 765             


Ile Lys His Asn Gln Asn Phe Ile Ser Asn Gly Val Ile Ser His Asn 
    770                 775                 780                 


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
785                 790                 795                 800 


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
                805                 810                 815     


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
            820                 825                 830         


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840                 845             


<210>  352
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_RNR-1

<400>  352

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Leu Gly Arg Asp Glu Leu Ile Phe Ile Lys Glu Gly Asp 
    290                 295                 300                 


Lys Leu Lys Val Cys Lys Ile Gly Glu Ala Ile Asp Glu Phe Met Glu 
305                 310                 315                 320 


Lys Tyr Lys Asp Lys Ile Ile Val Asp Gly Asp Thr Glu Ile Leu Tyr 
                325                 330                 335     


Leu Asp Gly Ile Ala Glu Val Tyr Thr Ile Ser Val Asn Val Lys Thr 
            340                 345                 350         


Gly Lys Ala Glu Phe Lys Arg Val Tyr Ala Ile Ser Arg His Lys Pro 
        355                 360                 365             


Arg Gly Lys Val Tyr Lys Val Ile Gly Lys Asp Gly Thr Ser Ile Ile 
    370                 375                 380                 


Val Thr Glu Asp His Ser Leu Phe Asn Tyr Asp Glu Asn Gly Asn Leu 
385                 390                 395                 400 


Val Cys Val Lys Pro Arg Gln Met Lys His Ile Ile Arg Asn Phe Asn 
                405                 410                 415     


Asn Pro Tyr Asp Val Glu Tyr Arg Ile Gly Asp Tyr Ile Glu Thr Asn 
            420                 425                 430         


Tyr Gln Arg Thr Asp Ser Lys Tyr Asn Ser Arg Gln Asn Asp Ile Pro 
        435                 440                 445             


Glu Lys Leu Lys Ile Thr Lys Glu Leu Cys Gln Phe Leu Gly Leu Phe 
    450                 455                 460                 


Val Ala Glu Gly Ser Tyr Ile Thr Asn Gly Ile Ser Ile Thr Thr Lys 
465                 470                 475                 480 


Asp Asp Asp Ile Ala Lys Phe Ile Glu Arg Phe Val Lys Glu Gln Ile 
                485                 490                 495     


Asn Glu Asn Ile Ala Val Lys Arg Tyr Glu Asp Ser Val Arg Phe Val 
            500                 505                 510         


Asn Lys Gly Phe Tyr Arg Phe Leu Lys Glu His Ile Asn Gly Lys Ala 
        515                 520                 525             


Ile Asn Lys Asn Ser Pro Glu Phe Ile Leu Lys Gly Asp Lys Glu Met 
    530                 535                 540                 


Lys Leu Ala Phe Leu Gly Gly Leu Ile Ser Gly Asp Gly Tyr Val Ser 
545                 550                 555                 560 


Lys Asp Gly Arg Val Gln Ile Tyr Thr Thr Ser Glu Gln Leu Leu Gly 
                565                 570                 575     


Gln Leu His Leu Leu Leu Ser Asp Leu Gly Met Ile Tyr Ser Ile Thr 
            580                 585                 590         


Lys Ile Lys Glu Glu Gly Glu Lys Ile Glu Ile Lys Arg Asn Glu Ile 
        595                 600                 605             


Val Arg Asn Tyr Lys Leu Tyr Val Ile Glu Ile Ala Lys Asn Cys Thr 
    610                 615                 620                 


Glu Asp Leu Lys Pro Tyr Val Ile Pro Lys Tyr Lys Lys Glu Arg Ile 
625                 630                 635                 640 


Lys Pro Ala Asn Tyr Asp Gln Leu Pro Tyr Asp Tyr Arg Ile Ile Lys 
                645                 650                 655     


Glu His Leu Arg Lys Ile Thr Asp Lys Lys Pro Tyr Asn Asp Tyr Ala 
            660                 665                 670         


Trp Lys Ser Asn Asn Arg Lys Leu Lys Leu Asn Thr Leu Glu Lys Ile 
        675                 680                 685             


Glu Gln Leu Asn Pro His Leu Arg Glu Glu Ile Asn Lys Phe Lys Leu 
    690                 695                 700                 


Asn Ile Pro Phe Glu Ile Lys Glu Ile Lys Glu Ile Asp Tyr Asn Gly 
705                 710                 715                 720 


Tyr Val Tyr Asp Leu Ser Val Glu Asp Asn Glu Asn Phe Ile Thr Ala 
                725                 730                 735     


Thr Gly Ile Leu Cys His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
            740                 745                 750         


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
        755                 760                 765             


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
    770                 775                 780                 


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
785                 790                 795                 800 


Asn Ala Glu Ala Ala Thr Arg 
                805         


<210>  353
<211>  887
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_RNR-2

<400>  353

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Leu Pro Tyr Asp Glu Lys Ile Leu Ile Phe Glu Asn Asn 
    290                 295                 300                 


Glu Tyr Lys Leu Val Lys Ile Gly Glu Phe Val Glu Lys Tyr Leu Asn 
305                 310                 315                 320 


Arg Tyr Lys Asp Arg Ala Ile Thr Tyr Gly Asp Asn Asn Ile Glu Val 
                325                 330                 335     


Tyr Ile Lys Asp Glu Asn Ile Tyr Ala Pro Ser Phe Asp Lys Asp Gly 
            340                 345                 350         


Lys Ile Val Leu Lys Pro Ile Thr His Ala Ile Arg His Arg Gly Lys 
        355                 360                 365             


Glu Ile Tyr Glu Ile Glu Leu Glu Ser Gly Lys Lys Val Arg Val Thr 
    370                 375                 380                 


Gly Asp His Ser Val Phe Thr Ile Asn Asp Asn Leu Asp Val Val Glu 
385                 390                 395                 400 


Val Lys Ala Ser Asp Leu Lys Val Gly Asp Phe Ile Ile Thr Pro Lys 
                405                 410                 415     


Ile Ile Pro Ser Ile Ser Lys Asp Lys Ile Tyr Leu Ser Glu Ile Val 
            420                 425                 430         


Lys Asn Lys Asp Lys Tyr Tyr Val Lys Ile Lys Asp His Ile Lys Phe 
        435                 440                 445             


Ile Glu Glu His Glu Glu Ile Leu Lys Glu Ser Tyr Lys Glu Tyr Lys 
    450                 455                 460                 


Thr Lys Trp Lys Asp Leu Lys Pro Val Leu Lys Lys Lys Asn Ala Phe 
465                 470                 475                 480 


Arg Leu Asp Leu Ile Glu Asp Leu Val Asp Lys Glu Lys Ile Glu Lys 
                485                 490                 495     


Ile Ser Tyr Gly His Ala Asn Tyr Ile Asn Asn Lys Ile Lys Leu Asp 
            500                 505                 510         


Glu Lys Phe Gly Tyr Leu Ile Gly Ala Phe Leu Ser Glu Gly His Trp 
        515                 520                 525             


Asn Asp Lys Cys Val Glu Ile Ser Ser Thr Asn Lys Glu Phe Ile Glu 
    530                 535                 540                 


Asn Leu Val Glu Ile Ile Glu Glu Ile Leu Gly Lys Asp Ala Tyr Tyr 
545                 550                 555                 560 


Ile Thr Val Lys Gly Asp Lys Arg Arg Tyr Lys Asp Leu Tyr Val Ile 
                565                 570                 575     


Gly Leu Asn Lys Thr Val Ala Met Ile Phe Glu Ser Leu Gly Leu Asn 
            580                 585                 590         


Lys Leu Ser Ser Asn Lys Glu Ile Pro Ser Ile Leu Leu Ser Asn Glu 
        595                 600                 605             


Thr Phe Leu Lys Gly Leu Ile Lys Gly Tyr Ile Asp Gly Asp Gly Ser 
    610                 615                 620                 


Ile Tyr Val Asp Glu Ser Lys Arg Asp Tyr Ser Ile Arg Leu Tyr Thr 
625                 630                 635                 640 


Thr Ser Glu Thr Leu Arg Asp Thr Leu Cys Leu Ala Leu Lys Ile Leu 
                645                 650                 655     


Gly Ile Asn Tyr Arg Leu Ser Ile Asp Lys Lys Ser Lys Val Asn Glu 
            660                 665                 670         


Asn Trp Arg Asp Cys Tyr Val Ile Lys Ile Thr Gly Lys Glu Asn Ile 
        675                 680                 685             


Glu Lys Leu Leu Asp Val Glu Ile Lys Asn Asn Gly Gly Lys Asp Val 
    690                 695                 700                 


Ile Pro Lys Ile Ala Glu Lys Phe Lys Glu Ile Ile Asn Gln Tyr Ser 
705                 710                 715                 720 


Gln Arg Glu Trp Lys Glu Arg Phe Gly Ile Asp Val Asn Asn Leu His 
                725                 730                 735     


Ile Trp Glu Asp Leu Lys Lys Gly Tyr Met Ser Arg Tyr Arg Ala Lys 
            740                 745                 750         


Lys Val Leu Asn Ile Met Lys Asn Val Lys Glu Ile Glu Glu Lys Tyr 
        755                 760                 765             


Gly Arg Leu Leu Asp Lys Ile Gly Gln Leu Ile Asp Asn Asp Leu Leu 
    770                 775                 780                 


Phe Glu Arg Ile Lys Ser Ile Arg Val Leu Asp Glu Ile Pro Glu Tyr 
785                 790                 795                 800 


Val Tyr Asp Ile Ser Val Glu Gly Thr Glu Asn Phe Ile Gly Gly Glu 
                805                 810                 815     


Gly Phe Ile Cys Leu His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
            820                 825                 830         


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
        835                 840                 845             


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
    850                 855                 860                 


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
865                 870                 875                 880 


Asn Ala Glu Ala Ala Thr Arg 
                885         


<210>  354
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_rPol_Ap

<400>  354

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Asp Gly Asp Thr Thr Val Leu Leu Asp Gly Lys Leu 
    290                 295                 300                 


Ile Lys Ile Lys Asp Leu Glu Asp Lys Trp Lys Asp Val Lys Val Leu 
305                 310                 315                 320 


Thr Ser Asp Asp Leu Asn Pro Lys Leu Thr Ser Leu Ser Lys Tyr Trp 
                325                 330                 335     


Lys Leu Asn Ala Asp Glu Tyr Gly Lys Lys Ile Tyr Lys Ile Lys Thr 
            340                 345                 350         


Glu Leu Gly Arg Glu Ile Ile Ala Thr Glu Asp His Pro Phe Tyr Thr 
        355                 360                 365             


Thr Asn Gly Arg Lys Arg Cys Gly Glu Leu Lys Val Gly Asp Glu Val 
    370                 375                 380                 


Ile Ile Tyr Pro Asn Asp Phe Pro Met Phe Glu Asp Asp Asn Arg Val 
385                 390                 395                 400 


Ile Val Asp Glu Glu Lys Ile Lys Lys Val Ile Asn Asn Ile Gly Gly 
                405                 410                 415     


Thr Tyr Lys Asn Lys Ile Ile Asn Glu Leu Lys Asp Arg Lys Leu Ile 
            420                 425                 430         


Pro Leu Thr Tyr Asn Asp Gln Lys Ala Ser Ile Leu Ala Arg Ile Val 
        435                 440                 445             


Gly His Val Met Gly Asp Gly Ser Leu Ile Ile Asn Asn Lys Asn Ser 
    450                 455                 460                 


Arg Val Val Phe Arg Gly Asp Ile Glu Asp Leu Lys Thr Ile Lys Glu 
465                 470                 475                 480 


Asp Leu Lys Glu Leu Gly Tyr Asp Gly Glu Glu Ile Lys Leu His Glu 
                485                 490                 495     


Gly Glu Thr Glu Ile Thr Asp Tyr Asn Gly Lys Lys Arg Ile Ile Lys 
            500                 505                 510         


Gly Lys Gly Tyr Ser Phe Glu Val Arg Lys Lys Ser Leu Cys Ile Leu 
        515                 520                 525             


Leu Lys Ala Leu Gly Cys Val Gly Gly Asp Lys Thr Lys Lys Met Tyr 
    530                 535                 540                 


Gly Ile Pro Asn Trp Ile Lys Thr Ala Pro Lys Tyr Ile Lys Lys Glu 
545                 550                 555                 560 


Phe Leu Ser Ala Tyr Phe Gly Ser Glu Leu Thr Thr Pro Lys Ile Arg 
                565                 570                 575     


Asn His Gly Thr Ser Phe Lys Glu Leu Ser Phe Lys Ile Ala Lys Ile 
            580                 585                 590         


Glu Glu Ile Phe Asp Glu Asp Arg Phe Ile Lys Asp Ile Lys Glu Met 
        595                 600                 605             


Leu Lys Glu Phe Gly Ile Glu Leu Lys Val Arg Val Glu Glu Gly Asn 
    610                 615                 620                 


Leu Arg Lys Asp Gly Tyr Lys Thr Lys Val Tyr Val Ala Ser Ile Tyr 
625                 630                 635                 640 


Asn His Lys Glu Phe Phe Gly Arg Ile Gly Tyr Thr Tyr Ala Asn Lys 
                645                 650                 655     


Lys Glu Thr Leu Ala Arg Tyr Ala Tyr Glu Tyr Leu Leu Thr Lys Glu 
            660                 665                 670         


Lys Tyr Leu Lys Asp Arg Asn Ile Lys Lys Leu Glu Asn Asn Thr Lys 
        675                 680                 685             


Phe Ile Thr Phe Asp Lys Phe Ile Lys Glu Lys Cys Leu Lys Asn Gly 
    690                 695                 700                 


Phe Val Lys Glu Lys Ile Val Ser Ile Glu Glu Thr Lys Val Asp Tyr 
705                 710                 715                 720 


Val Tyr Asp Ile Thr Thr Ile Ser Glu Thr His Asn Phe Ile Ala Asn 
                725                 730                 735     


Gly Phe Leu Thr Gly Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
            740                 745                 750         


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
        755                 760                 765             


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
    770                 775                 780                 


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
785                 790                 795                 800 


Ala Glu Ala Ala Thr Arg 
                805     


<210>  355
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_rPol_App

<400>  355

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Leu Pro Tyr Glu Glu Lys Ile Ile Ile Lys Glu Gly Glu 
    290                 295                 300                 


Phe Ile Lys Pro Val Glu Ile Gly Lys Leu Val Asp Glu Met Ile Glu 
305                 310                 315                 320 


Arg Phe Gly Phe Glu Lys Ile Gly Asn Ser Glu Val Cys Asp Leu Pro 
                325                 330                 335     


Ile Asp Ile Tyr Ala Leu Ser Leu Asp Gln Asp Glu Lys Val His Trp 
            340                 345                 350         


Lys Arg Ile Ile Ser Cys Ile Arg His Lys His Asn Gly Lys Leu Ile 
        355                 360                 365             


Lys Ile Lys Thr Lys Ser Gly Arg Glu Ile Thr Ala Thr Pro Tyr His 
    370                 375                 380                 


Ser Phe Val Ile Arg Lys Asp Asn Lys Ile Ile Pro Val Lys Gly Ser 
385                 390                 395                 400 


Glu Leu Lys Ile Gly Asp Arg Ile Pro Val Val Lys His Ile Pro Ala 
                405                 410                 415     


Asn Cys Val Glu Ala Ile Asn Ile Ser Asp Tyr Val Ser Gly Asn Tyr 
            420                 425                 430         


Val Val Asp Asn Ile Asn Asn Lys Ile Ala Pro Lys Ile Asn Gly Lys 
        435                 440                 445             


Ser Ile Pro Asn Asn Ile Lys Leu Asp Tyr Asp Phe Gly Tyr Phe Ile 
    450                 455                 460                 


Gly Ile Tyr Leu Ala Glu Gly Ser Val Thr Lys Tyr Phe Val Ser Ile 
465                 470                 475                 480 


Ser Asn Val Asp Glu Leu Ile Leu Asn Lys Ile Arg Ala Phe Ala Asp 
                485                 490                 495     


Lys Leu Gly Leu Asn Tyr Gly Glu Tyr Asp Asn Asn Asn Gly Phe Ala 
            500                 505                 510         


Glu Ser His Asp Ile Arg Ile Tyr Ser Ser Thr Leu Ala Glu Phe Leu 
        515                 520                 525             


Ser Asn Phe Gly Thr Ser Ser Asn Thr Lys Lys Ile Ala Glu Phe Val 
    530                 535                 540                 


Phe Gly Ala Asn Lys Glu Phe Val Arg Gly Leu Ile Arg Gly Tyr Phe 
545                 550                 555                 560 


Asp Gly Asp Gly Asn Val Asn Ala Asp Arg Lys Val Ile Arg Val Thr 
                565                 570                 575     


Ser Asn Ser Lys Glu Leu Ile Asp Gly Ile Ala Ile Leu Leu Ala Arg 
            580                 585                 590         


Phe Asn Ile Phe Ser Ile Lys Thr Lys Thr Lys Asn Gln Phe Val Leu 
        595                 600                 605             


Ile Ile Pro His Arg Tyr Ala Lys Lys Phe His Glu Glu Ile Asn Phe 
    610                 615                 620                 


Ser Val Glu Lys Lys Lys Ser Glu Leu Glu Arg Leu Val Ser Ser Leu 
625                 630                 635                 640 


Asn Asp Asp Lys Thr Tyr Asp Ser Ile Asp Met Ile Pro Ser Ile Gly 
                645                 650                 655     


Asp Ala Leu Thr Lys Leu Gly Glu Lys Val Asp Tyr Pro Lys Val Ile 
            660                 665                 670         


Leu Lys Lys Phe Glu Arg Lys Gln Lys Ile Gly Arg Ala Thr Leu Gln 
        675                 680                 685             


Arg His Leu Arg Arg Ile Glu Glu Leu Ala Val Lys Lys Gly Val Asn 
    690                 695                 700                 


Ile Leu Ala Leu Lys Glu Tyr Trp Leu Leu Lys Lys Ala Val Glu Ser 
705                 710                 715                 720 


Asp Val Ile Trp Asp Glu Ile Val Lys Ile Glu Glu Ile Ser Cys Asp 
                725                 730                 735     


Lys Lys Tyr Val Tyr Asp Ile Ser Val Glu Gly Leu Glu Thr Phe Thr 
            740                 745                 750         


Thr Phe Asp Gly Val Leu Thr His Asn Ser Thr Tyr Ala Ser Leu Asn 
        755                 760                 765             


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
    770                 775                 780                 


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
785                 790                 795                 800 


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
                805                 810                 815     


Leu Val Asn Ala Glu Ala Ala Thr Arg 
            820                 825 


<210>  356
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Mja_RtcB_Mja_Hyp-2

<400>  356

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Ser Asn Ser Lys Ile Leu Thr Asp Asp Gly Tyr 
    290                 295                 300                 


Tyr Ile Lys Leu Glu Lys Leu Lys Glu Lys Leu Asp Leu His Ile Lys 
305                 310                 315                 320 


Ile Tyr Asn Thr Glu Glu Gly Glu Lys Ser Ser Asn Ile Leu Phe Val 
                325                 330                 335     


Ser Glu Arg Tyr Ala Asp Glu Lys Ile Ile Arg Ile Lys Thr Glu Ser 
            340                 345                 350         


Gly Arg Val Leu Glu Gly Ser Lys Asp His Pro Val Leu Thr Leu Asn 
        355                 360                 365             


Gly Tyr Val Pro Met Gly Met Leu Lys Glu Gly Asp Asp Val Ile Val 
    370                 375                 380                 


Tyr Pro Tyr Glu Gly Val Glu Tyr Glu Glu Pro Ser Asp Glu Ile Ile 
385                 390                 395                 400 


Leu Asp Glu Asp Asp Phe Ala Glu Tyr Asp Lys Gln Ile Ile Lys Tyr 
                405                 410                 415     


Leu Lys Asp Arg Gly Leu Leu Pro Leu Arg Met Asp Asn Lys Asn Ile 
            420                 425                 430         


Gly Ile Ile Ala Arg Leu Leu Gly Phe Ala Phe Gly Asp Gly Ser Ile 
        435                 440                 445             


Val Lys Glu Asn Gly Asp Arg Glu Arg Leu Tyr Val Ala Phe Tyr Gly 
    450                 455                 460                 


Lys Arg Glu Thr Leu Ile Lys Ile Arg Glu Asp Leu Glu Lys Leu Gly 
465                 470                 475                 480 


Ile Lys Ala Ser Arg Ile Tyr Ser Arg Lys Arg Glu Val Glu Ile Arg 
                485                 490                 495     


Asn Ala Tyr Gly Asp Glu Tyr Thr Ser Leu Cys Glu Asp Asn Ser Ile 
            500                 505                 510         


Lys Ile Thr Ser Lys Ala Phe Ala Leu Phe Met His Lys Leu Gly Met 
        515                 520                 525             


Pro Ile Gly Lys Lys Thr Glu Gln Ile Tyr Lys Ile Pro Glu Trp Ile 
    530                 535                 540                 


Lys Lys Ala Pro Lys Trp Val Lys Arg Asn Phe Leu Ala Gly Leu Phe 
545                 550                 555                 560 


Gly Ala Asp Gly Ser Arg Ala Val Phe Lys Asn Tyr Thr Pro Leu Pro 
                565                 570                 575     


Ile Asn Leu Thr Met Ser Lys Ser Glu Glu Leu Lys Glu Asn Ile Leu 
            580                 585                 590         


Glu Phe Leu Asn Glu Ile Lys Leu Leu Leu Ala Glu Phe Asp Ile Glu 
        595                 600                 605             


Ser Met Ile Tyr Glu Ile Lys Ser Leu Asp Gly Arg Val Ser Tyr Arg 
    610                 615                 620                 


Leu Ala Ile Val Gly Glu Glu Ser Ile Lys Asn Phe Leu Gly Arg Ile 
625                 630                 635                 640 


Asn Tyr Glu Tyr Ser Gly Glu Lys Lys Val Ile Gly Leu Leu Ala Tyr 
                645                 650                 655     


Glu Tyr Leu Arg Arg Lys Asp Ile Ala Lys Glu Ile Arg Lys Lys Cys 
            660                 665                 670         


Ile Lys Arg Ala Lys Glu Leu Tyr Lys Lys Gly Val Thr Val Ser Glu 
        675                 680                 685             


Met Leu Lys Met Asp Glu Phe Arg Asn Glu Phe Ile Ser Lys Arg Leu 
    690                 695                 700                 


Ile Glu Arg Ala Val Tyr Glu Asn Leu Asp Glu Asp Asp Val Arg Ile 
705                 710                 715                 720 


Ser Thr Lys Phe Pro Lys Phe Glu Glu Phe Ile Glu Lys Tyr Gly Val 
                725                 730                 735     


Ile Gly Gly Phe Val Ile Asp Lys Ile Lys Glu Ile Glu Glu Ile Ser 
            740                 745                 750         


Tyr Asp Ser Lys Leu Tyr Asp Val Gly Ile Val Ser Lys Glu His Asn 
        755                 760                 765             


Phe Ile Ala Asn Ser Ile Val Val His Asn Ser Thr Tyr Ala Ser Leu 
    770                 775                 780                 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
785                 790                 795                 800 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
                805                 810                 815     


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
            820                 825                 830         


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840         


<210>  357
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_TFIIB

<400>  357

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Val Asp Tyr Asn Glu Pro Ile Ile Ile Lys Glu Asn Gly 
    290                 295                 300                 


Glu Ile Lys Val Val Lys Ile Gly Glu Leu Ile Asp Lys Ile Ile Glu 
305                 310                 315                 320 


Asn Ser Glu Asn Ile Arg Arg Glu Gly Ile Leu Glu Ile Ala Lys Cys 
                325                 330                 335     


Lys Gly Ile Glu Val Ile Ala Phe Asn Ser Asn Tyr Lys Phe Lys Phe 
            340                 345                 350         


Met Pro Val Ser Glu Val Ser Arg His Pro Val Ser Glu Met Phe Glu 
        355                 360                 365             


Ile Val Val Glu Gly Asn Lys Lys Val Arg Val Thr Arg Ser His Ser 
    370                 375                 380                 


Val Phe Thr Ile Arg Asp Asn Glu Val Val Pro Ile Arg Val Asp Glu 
385                 390                 395                 400 


Leu Lys Val Gly Asp Ile Leu Val Leu Ala Lys Glu Leu Pro Asn Ile 
                405                 410                 415     


Glu Glu Asp Ile Glu Ile Asp Lys Lys Phe Ser Lys Ile Leu Gly Tyr 
            420                 425                 430         


Ile Ile Ala Glu Gly Tyr Tyr Asp Asp Lys Lys Ile Val Leu Ser Tyr 
        435                 440                 445             


Asp Tyr Asn Glu Lys Glu Phe Ile Asn Glu Thr Ile Asp Tyr Phe Lys 
    450                 455                 460                 


Ser Leu Asn Ser Asp Ile Thr Ile Tyr Ser Lys Asp Leu Asn Ile Gln 
465                 470                 475                 480 


Ile Glu Val Lys Asn Lys Lys Ile Ile Asn Leu Leu Lys Lys Leu Arg 
                485                 490                 495     


Val Lys Asn Lys Arg Ile Pro Ser Ile Ile Phe Lys Ser Pro Tyr Glu 
            500                 505                 510         


Ile Lys Lys Ser Phe Ile Asp Gly Ile Phe Asn Gly Lys Asp Ala Lys 
        515                 520                 525             


Val Phe Val Ser Lys Glu Leu Ala Glu Asp Val Ile Phe Leu Leu Leu 
    530                 535                 540                 


Gln Ile Lys Glu Asn Ala Thr Ile Asn Lys Lys Ser Ile Asn Asp Ile 
545                 550                 555                 560 


Glu Val Tyr Glu Val Arg Arg Ile Thr Asn Ile Tyr Thr Asn Arg Lys 
                565                 570                 575     


Leu Glu Lys Leu Ile Asn Ser Asp Phe Ile Phe Leu Lys Ile Lys Glu 
            580                 585                 590         


Ile Asn Lys Val Glu Pro Thr Ser Gly Tyr Ala Tyr Asp Leu Thr Val 
        595                 600                 605             


Pro Asn Ala Glu Asn Phe Val Ala Gly Phe Gly Gly Phe Val Leu His 
    610                 615                 620                 


Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
625                 630                 635                 640 


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
                645                 650                 655     


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
            660                 665                 670         


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
        675                 680                 685             


Arg 
    


<210>  358
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_UDP_GD

<400>  358

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe His Pro Asp Glu Val Leu Phe Ile Asp Arg Gly Arg 
    290                 295                 300                 


Gly Leu Glu Cys Ile Thr Phe Lys Glu Leu Phe Glu Leu Glu Asp Lys 
305                 310                 315                 320 


Asp Asn Val Lys Ile Leu Ser Phe Asp Gly Glu Lys Leu Ser Leu Lys 
                325                 330                 335     


Lys Leu Lys Leu Ala Ser Lys Arg Tyr Tyr Asn Asp Asp Leu Ile Thr 
            340                 345                 350         


Leu Arg Phe Asn Leu Gly Arg Glu Ile Lys Ile Thr Lys Asp His Pro 
        355                 360                 365             


Val Val Ile Leu Glu Asp Gly Glu Leu Lys Ile Lys Leu Thr Ser Asp 
    370                 375                 380                 


Val Lys Glu Gly Asp Lys Val Ile Leu Pro Tyr Gly Asn Phe Gly Glu 
385                 390                 395                 400 


Glu Arg Glu Ile Glu Ile Asp Ile Leu Glu Glu Leu Ser Lys Thr Asp 
                405                 410                 415     


Leu Ile Glu Lys Val Trp Ile His Asn Lys Asp Leu Ala Thr Asn Glu 
            420                 425                 430         


Phe Asn Ile Ile Lys Pro Tyr Leu Ser Asn Lys Tyr Pro His Asp Val 
        435                 440                 445             


Lys Arg Asn Gly Thr Ile Arg Ala Lys Asp Ile Leu Pro Ile Lys Glu 
    450                 455                 460                 


Ile Leu Asp Lys Tyr Gly Ser Lys Asn Arg Leu Phe Thr Ala Lys Ser 
465                 470                 475                 480 


Lys Ser Thr Thr Ile Pro Tyr Lys Ile Lys Ile Asp Lys Asp Phe Ala 
                485                 490                 495     


Arg Leu Ile Gly Tyr Tyr Leu Ser Glu Gly Trp Ile Ser Lys Asp Tyr 
            500                 505                 510         


Gly Arg Asn Gly Val Val Arg Lys Arg Ile Gly Leu Cys Phe Gly Ile 
        515                 520                 525             


His Glu Glu Glu Tyr Ile Asn Asp Val Lys Asn Ile Leu Asn Lys Leu 
    530                 535                 540                 


Gly Ile Lys Tyr Ile Glu Lys Ile Lys Asp Gly Ser His Ser Ile Leu 
545                 550                 555                 560 


Ile Ser Ser Lys Ile Leu Ala Tyr Val Phe Glu Asn Ile Leu Asn Cys 
                565                 570                 575     


Gly Ile Asn Cys Tyr Asn Lys Asn Ile Pro Pro Gln Met Phe Asn Ala 
            580                 585                 590         


Lys Glu Glu Ile Lys Trp Glu Phe Leu Lys Gly Leu Phe Arg Gly Asp 
        595                 600                 605             


Gly Gly Ile Val Arg Leu Asn Asn Asn Lys Asn Leu Asn Ile Glu Phe 
    610                 615                 620                 


Ala Thr Val Ser Lys Lys Met Ala His Ser Leu Leu Ile Leu Leu Gln 
625                 630                 635                 640 


Leu Leu Gly Ile Val Ala Ser Val Lys Lys Cys Tyr Asn Asn Lys Ser 
                645                 650                 655     


Thr Thr Met Ala Tyr Ile Ile Arg Ile Asn Gly Leu Glu Gln Val Lys 
            660                 665                 670         


Lys Ile Gly Glu Leu Phe Gly Lys Lys Trp Glu Asn Tyr Lys Asp Ile 
        675                 680                 685             


Ala Glu Ser Tyr Lys Arg Asn Ile Glu Pro Leu Gly Tyr Lys Lys Ser 
    690                 695                 700                 


Asp Asn Phe Ala Ile Leu Glu Val Lys Glu Ile Ile Lys Glu His Tyr 
705                 710                 715                 720 


Ser Gly Tyr Val Tyr Ser Val Glu Thr Glu Asn Ser Leu Leu Ile Thr 
                725                 730                 735     


Ser Tyr Gly Ile Leu Ile His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
            740                 745                 750         


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
        755                 760                 765             


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
    770                 775                 780                 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
785                 790                 795                 800 


Val Asn Ala Glu Ala Ala Thr Arg 
                805             


<210>  359
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mka_CDC48

<400>  359

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Ile Pro Gly Asp Glu Val Val Trp Ala Lys Val Asp Gly 
    290                 295                 300                 


Glu Ala Lys Leu Ile Pro Ile Glu Asp Leu Tyr Glu Leu Trp Lys Glu 
305                 310                 315                 320 


Gly Arg Asp Val Glu Val Ala Ala Leu Thr Glu Glu Gly Val Val Trp 
                325                 330                 335     


Ser Ser Val Asp Arg Val Ala Arg His Arg Arg Arg Thr Gly Leu Val 
            340                 345                 350         


Lys Ile Ile Thr Arg Thr Gly Arg Glu Val Ile Val Thr Glu Asp His 
        355                 360                 365             


Ser Val Phe Thr Val Arg Asp Gly Lys Ile Val Asp Val Pro Thr Ser 
    370                 375                 380                 


Glu Leu Ser Glu Gly Asp Trp Ile Val Leu Pro Ala Arg Leu Pro Ala 
385                 390                 395                 400 


Gly Asp Ser Asp Glu Ile Asp Gly Ile Lys Ile Asp Glu Asp Leu Ala 
                405                 410                 415     


Phe Leu Leu Gly Leu Tyr Val Ala Glu Gly Ser Leu Thr Asn Gln Lys 
            420                 425                 430         


Asp Ala Val Arg Ile His Asn Lys Asp Pro Glu Val Ile Glu Glu Ile 
        435                 440                 445             


Asp Arg Ile Val Arg Glu Lys Gly Trp Glu Gly Arg Tyr Tyr Glu Ser 
    450                 455                 460                 


Asp His Ser Tyr Trp Ile Lys Ser Arg Lys Leu Arg Gln Leu Cys Glu 
465                 470                 475                 480 


Lys Leu Gly Thr Lys Ala Arg Glu Lys Arg Leu Gly Pro Leu Leu Ser 
                485                 490                 495     


Leu Lys Pro Glu Leu Leu Ala Ala Ala Leu Arg Gly Tyr Tyr Thr Gly 
            500                 505                 510         


Asp Gly Ser Phe Ser Val Lys Pro His Gly Arg Ser Ala Ile Ile Glu 
        515                 520                 525             


Ala Thr Thr Val Ser Lys Arg Leu Ala Asp Glu Leu Leu Val Ala Leu 
    530                 535                 540                 


Gln Ile Leu Asp Ile Val Ala Arg Arg Tyr Glu Cys Asp Asp Thr Lys 
545                 550                 555                 560 


Gly Ser Thr Arg Tyr Arg Val Met Ile Thr Lys Ser Glu Tyr Ile Arg 
                565                 570                 575     


Thr Phe Val Glu Lys Val Gly Phe Ala Gln Ser Glu Lys Asn Glu Arg 
            580                 585                 590         


Ile Arg Lys Phe Leu Ala Glu Arg Lys Trp Thr Arg Gly Arg Ser Asp 
        595                 600                 605             


Ile Pro Thr Glu Leu Ile Gly Ser Pro Tyr Thr Tyr Val Glu Val Glu 
    610                 615                 620                 


Tyr Ile Ser Asp Arg Val Ala Ala Asp Gly Gly Leu Met Lys Ala Glu 
625                 630                 635                 640 


Leu Glu His Leu Tyr Phe Asp Lys Ile Lys Glu Ile Val Pro Leu Asp 
                645                 650                 655     


Arg Asp Asp Glu Tyr Val Tyr Asp Val Val Glu Val Lys Leu Gly His 
            660                 665                 670         


Asn Phe Val Gly Gly Gln Gly Val Leu Leu His Asn Ser Thr Tyr Ala 
        675                 680                 685             


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
    690                 695                 700                 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
705                 710                 715                 720 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
                725                 730                 735     


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            740                 745             


<210>  360
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mka_EF2

<400>  360

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ala Pro Glu Thr Lys Ile Cys Leu Ala Asp Gly Arg 
    290                 295                 300                 


Phe Val Arg Ala Asp Glu Leu Phe Glu Glu Leu Lys Glu Arg Gly Arg 
305                 310                 315                 320 


Leu Val Lys Cys Asp Glu Ser Glu Glu Val Tyr Glu Leu Arg Glu Pro 
                325                 330                 335     


Val Gly Val Ser Ser Leu Asp Lys Asp Ala Val Glu Ile Val Glu Gly 
            340                 345                 350         


Lys Ile Thr His Val Trp Arg Leu Lys Ala Asp Lys Leu Val Glu Val 
        355                 360                 365             


Glu Val Lys Asn Gly Arg Ser Ile Arg Thr Thr Pro Glu His Lys Phe 
    370                 375                 380                 


Leu Val Leu Asp Pro Ser Gly Glu Ile Val Glu Lys Arg Ala Asp Glu 
385                 390                 395                 400 


Leu Glu Ile Gly Asp Tyr Ile Val Cys Thr Gln Lys Leu Val His Glu 
                405                 410                 415     


Gly Met Ser Glu Glu Glu Leu Lys Arg Glu Val Phe Arg Arg Leu Gly 
            420                 425                 430         


Arg Asp Phe Phe Val His Leu Pro Glu Glu Glu Ala Glu Ser Val Leu 
        435                 440                 445             


Glu Leu Ala Lys Glu Arg Gly Ile Lys Ala Leu Trp Glu Thr Leu Glu 
    450                 455                 460                 


Val Asp Ile Glu Glu Asn Ser Phe Tyr Tyr Gln Leu Arg Lys Gly Arg 
465                 470                 475                 480 


Ile Arg Ala Asp Ile Leu Val Asp Leu Ala Glu Glu Leu Gly Leu Asp 
                485                 490                 495     


Leu Ala Asp Leu Tyr Asp Ala Val Glu Val Ser Tyr Arg Ser Asn Thr 
            500                 505                 510         


Lys Ser Thr Lys Pro Ile Arg Leu Pro Glu Pro Glu Asp Leu Phe Tyr 
        515                 520                 525             


Leu Ala Gly Leu Met Phe Gly Asp Gly Cys Trp Asn Gln Leu Thr Asn 
    530                 535                 540                 


Gly Ser Glu Ala Ile Gln Gly Glu Val Lys Arg Ile Ala Ser Asp Met 
545                 550                 555                 560 


Gly Leu Glu Val Arg Val Arg Arg Tyr Glu Gly Lys Thr Ala Arg Ile 
                565                 570                 575     


Asp Phe Pro Glu Thr Val Pro Arg Ile Leu Glu Ala Leu Phe Asp Tyr 
            580                 585                 590         


Pro Arg Arg Lys Lys Ala His Arg Ile Arg Val Asn Asp Phe Leu Thr 
        595                 600                 605             


Arg Ala Pro Leu Asp Cys Ile Ala Glu Phe Ile Arg Gly Tyr Phe Asp 
    610                 615                 620                 


Ala Asp Gly Thr Val Glu Glu Gly Arg Ser Ala Val Ser Val Thr Ser 
625                 630                 635                 640 


Val Ser Arg Glu Phe Leu Glu Asp Leu Gln Leu Leu Leu Gln Lys Phe 
                645                 650                 655     


Asp Val Ala Ser Tyr Leu Arg Glu Gly Asp Gly Ala Tyr Thr Leu Tyr 
            660                 665                 670         


Val Ser Gly Ala Arg Ser Leu Glu Arg Phe Pro Gly Phe Arg Glu Pro 
        675                 680                 685             


Glu Lys Ala Glu Lys Leu Lys Lys Leu Met Glu Lys Ala Ser Ser Ser 
    690                 695                 700                 


Glu Leu Glu Lys Val Pro Ile Ser Gly Glu Ile Leu Arg Glu Val Arg 
705                 710                 715                 720 


Gly Asp Val Pro Thr Thr Arg Met Phe Asn Cys Tyr Ser Asn Tyr Glu 
                725                 730                 735     


Gly Gly Gln Val Gly Leu Thr Lys Ser Ser Leu Glu Lys Val Ile Ser 
            740                 745                 750         


Thr Leu Glu Ala Val Gly Val Glu Gly Glu Ala Leu Glu Arg Leu Lys 
        755                 760                 765             


Ala Leu Ala Arg Asp Asp Val Cys Phe Leu Glu Val Val Arg Val Glu 
    770                 775                 780                 


Glu Val Glu Tyr Asp Gly Tyr Val Tyr Asp Phe Thr Val Glu Glu His 
785                 790                 795                 800 


His Asn Phe Ala Ala Glu Gly Phe Val Val His Asn Ser Thr Tyr Ala 
                805                 810                 815     


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
            820                 825                 830         


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
        835                 840                 845             


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
    850                 855                 860                 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
865                 870                 875     


<210>  361
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mka_RFC

<400>  361

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Val Ser Ala Asp Thr Pro Ile Leu Val Arg Arg Gly Gly 
    290                 295                 300                 


Glu Val Leu Arg Val Thr Phe Glu Asp Leu Asp Ser Trp Tyr Phe Gly 
305                 310                 315                 320 


Asp Arg Gly Gly Glu Tyr Val Asp Val Ser Asp Leu Glu Val Leu Thr 
                325                 330                 335     


Val Asp Arg Asn Phe Arg Val Thr Trp Ala Arg Val Ser Lys Leu Ile 
            340                 345                 350         


Arg His Arg Ala Arg Lys Ile Leu Arg Val His Leu Glu Asp Gly Thr 
        355                 360                 365             


Ile Glu Leu Thr Gly Asn His Ala Val Met Val Leu Asp Glu Gly Gly 
    370                 375                 380                 


Leu Arg Ala Val Lys Ala Ser Glu Ile Glu Glu Gly Ser Phe Leu Leu 
385                 390                 395                 400 


Ser Phe Val Ala Glu Leu Asp Glu Gln Pro Thr Asp Gly Gly Thr Val 
                405                 410                 415     


Val Thr Ser Val Gly Ser Gly Ser Arg Val Ser Asp Thr Thr Tyr Glu 
            420                 425                 430         


Leu Pro Val Glu Val Arg Val Glu Leu Leu Arg Glu Leu Ala Asp Asp 
        435                 440                 445             


Gly Val Ile Glu Ala Ser Glu Asp Val Ser Val Asp Leu Ala Trp Leu 
    450                 455                 460                 


Ala Arg Ile Ser Gly Val Glu Ser Arg Val Thr Asp Asp Gly Val Glu 
465                 470                 475                 480 


Leu Val Trp Glu Thr Arg Thr Gly Asp Leu Leu Pro Ala Asp Pro Val 
                485                 490                 495     


Leu Lys Leu Val Glu Arg Leu Glu Ser Asp Leu Val Asp Asp Leu Glu 
            500                 505                 510         


Ser Trp Val Phe Asp Gly Arg Val Ser Lys Glu Ala Val Arg Lys Val 
        515                 520                 525             


Leu Ser Ser Val Asp Ala Lys Asn Leu Arg Gly Asp Ala Arg Arg Ala 
    530                 535                 540                 


Tyr Arg Met Leu Arg Thr Leu Val Arg Ser Asp Val His Ala Val Lys 
545                 550                 555                 560 


Val Glu Asp Leu Asp Val Met Asp Tyr Asp Gly Tyr Val Tyr Asp Val 
                565                 570                 575     


Ser Val Pro Gly Asn Glu Met Phe Phe Ala Gly Glu Val Pro Val Leu 
            580                 585                 590         


Leu His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
        595                 600                 605             


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
    610                 615                 620                 


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
625                 630                 635                 640 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
                645                 650                 655     


Ala Thr Arg 
            


<210>  362
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mka_RtcB

<400>  362

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ala Pro Gly Thr Lys Ile Leu Thr Glu His Gly Cys 
    290                 295                 300                 


Trp Val Lys Val Glu Asp Leu Pro Lys Met Leu Thr Asp Gln Lys Leu 
305                 310                 315                 320 


Lys Val Tyr Asp Val Asp Glu Gly Arg Glu Asp Asp Ser Glu Ile Lys 
                325                 330                 335     


Phe Val Met Glu Arg Gly Ile Glu Glu Asp Glu Arg Ala Val Val Leu 
            340                 345                 350         


Val Thr Glu Ser Gly Leu Thr Ile Glu Gly Ser Glu Asp His Pro Val 
        355                 360                 365             


Leu Thr Pro Glu Gly Tyr Val Glu Leu Gly Glu Ile Glu Glu Gly Asp 
    370                 375                 380                 


Leu Val Val Val Tyr Pro Phe Glu Gly Val Glu Tyr Glu Glu Lys Glu 
385                 390                 395                 400 


Gly Thr Ile Leu Asp Glu Ser Asp Phe Glu Asp Val Asp Pro Gln Val 
                405                 410                 415     


Leu Arg Tyr Leu Glu Glu Arg Asp Leu Ile Pro Leu Arg Trp Ser Asp 
            420                 425                 430         


Pro Lys Val Gly Thr Leu Ala Arg Ile Leu Gly Phe Ala Met Gly Asp 
        435                 440                 445             


Gly His Leu Gly Glu Gln Ala Gly Arg Leu Thr Leu Ser Phe Tyr Gly 
    450                 455                 460                 


Asp Glu Arg Thr Leu Arg Glu Leu Lys Arg Asp Leu Glu Ser Leu Gly 
465                 470                 475                 480 


Val Lys Ala Asn Leu His Val Arg Lys Arg Arg Tyr Glu Ile Glu Thr 
                485                 490                 495     


Ala Ser Gly Arg Tyr Glu Gly Glu Ala Thr Ser Val Glu Leu Arg Val 
            500                 505                 510         


Ala Ser Arg Ser Phe Ala Leu Leu Met Glu Lys Leu Gly Met Pro Arg 
        515                 520                 525             


Gly Arg Lys Val Glu Thr Pro Tyr Lys Val Pro Asp Trp Ile Lys Glu 
    530                 535                 540                 


Ala Pro Leu Trp Val Lys Arg Asn Phe Leu Ala Gly Leu Phe Ala Ala 
545                 550                 555                 560 


Asp Gly Ser Val Val Lys Phe Lys Arg Tyr Thr Pro Leu Pro Ile Asn 
                565                 570                 575     


Leu Thr Gln Ala Lys Val Glu Glu Leu Glu Glu Asn Leu Arg Glu Phe 
            580                 585                 590         


Met Asn Asp Val Ala Lys Leu Leu Arg Glu Phe Gly Ile Glu Thr Thr 
        595                 600                 605             


Leu Tyr Glu Val Lys Ser Lys Lys Asn Val Val Tyr Lys Leu Ala Ile 
    610                 615                 620                 


Val Gly Glu Glu Asn Ile Lys Arg Phe Leu Gly Lys Val Gly Tyr Glu 
625                 630                 635                 640 


Tyr Asp Pro Glu Lys Lys Val Glu Gly Leu Ala Ala Tyr Ala Tyr Leu 
                645                 650                 655     


Lys Leu Lys Glu Arg Val Lys Lys Asp Arg Lys Glu Ala Ala Glu Thr 
            660                 665                 670         


Ala Ala Glu Val Tyr Glu Glu Thr Gly Ser Ile Thr Lys Ala His Glu 
        675                 680                 685             


Ala Val Ala Asp Val Val Asn Arg Arg Phe Val Glu Arg Val Val Tyr 
    690                 695                 700                 


Asp Gly Gly Ile Ser Ser Val Arg Val Pro Glu Asp Phe Pro Thr Phe 
705                 710                 715                 720 


Glu Arg Phe Lys Glu Glu Arg Val Leu Ala Gly Gly Phe Val Ile Glu 
                725                 730                 735     


Glu Val Val Glu Val Lys Gly Val Glu Pro Glu Tyr Asp Arg Phe Tyr 
            740                 745                 750         


Asp Ile Gly Val Cys His Gly Ala His Asn Phe Ile Ala Asp Gly Val 
        755                 760                 765             


Val Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
    770                 775                 780                 


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
785                 790                 795                 800 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
                805                 810                 815     


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
            820                 825                 830         


Ala Ala Thr Arg 
        835     


<210>  363
<211>  871
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mka_VatB

<400>  363

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Pro Gly Thr Arg Val Ile Thr Ala Ser Gly Asp 
    290                 295                 300                 


Val Val Glu Ile Asp Glu Ile Val Glu Arg Ala Ala Glu Thr Ala Val 
305                 310                 315                 320 


Asp Gly Gly Leu Arg Glu Gly Ser Thr Glu Val Thr Val Gly Val Thr 
                325                 330                 335     


Asn Val Arg Thr Leu Ala Ala Trp Asp Gly Asp Leu Thr Ser Asn Asp 
            340                 345                 350         


Val Val Ala Val Glu Lys Ile Glu Ala Pro Ser Arg Ala Val Arg Val 
        355                 360                 365             


Arg Thr Arg Ser Gly Ala Glu Leu Val Val Ser Glu Asp His Lys Phe 
    370                 375                 380                 


Leu Val Asp Thr Glu Asp Gly Pro Arg Met Val Glu Ala Ser Glu Leu 
385                 390                 395                 400 


Lys Ser Gly Asp Glu Leu Tyr Ser Val Arg Glu Leu Arg Val Ser Glu 
                405                 410                 415     


Lys Val Pro Thr Tyr Leu Glu Leu Leu Leu Glu Ala Glu Asp Lys Phe 
            420                 425                 430         


Tyr Val His Pro Thr Glu Glu Phe Glu Glu Ala Val Ala Glu Arg Tyr 
        435                 440                 445             


Gly Ser Leu Ala Glu Ala Cys Arg Glu Lys Glu Leu Pro Tyr Arg Ala 
    450                 455                 460                 


Arg Glu Ala Lys Glu Arg Arg Tyr Tyr Glu Leu Ser Glu Phe Ala Arg 
465                 470                 475                 480 


Leu Ala Thr Ala Val Ile Glu Ser Val Asp Glu Ala Thr Glu Tyr Ile 
                485                 490                 495     


Asp Tyr Val Thr Ala Gly Gly Arg Lys Arg Val Lys Phe Ser Ser Pro 
            500                 505                 510         


Arg Pro Gly Lys Glu Val Met Tyr Val Ala Gly Leu Ile Ala Ser Asp 
        515                 520                 525             


Gly Ser Val Asp Thr Glu Arg Gly Phe Val Met Phe Ser Asn Thr Glu 
    530                 535                 540                 


Arg Glu Leu Leu Ser Ala Phe Glu Glu Ile Val Thr Glu Glu Phe Gly 
545                 550                 555                 560 


Val Asp Ala Ser Lys Thr Glu Asn Gln Asn Gly Val Thr Met Leu Arg 
                565                 570                 575     


Val Asn Ser Arg Val Leu Ala Arg Val Phe Glu Arg Leu Ala Asp Pro 
            580                 585                 590         


Lys Thr Val Leu Lys Met Pro Arg Glu Leu Val Ala Ala Tyr Leu Ala 
        595                 600                 605             


Gly Tyr Val Asp Gly Asp Gly His Leu Lys Asp Gly Lys Ile Val Ile 
    610                 615                 620                 


Thr Thr Ala Asp Arg Glu Arg Ala Gly Asp Leu Gln Leu Leu Leu Lys 
625                 630                 635                 640 


Arg Leu Gly Val Pro Ser Val Leu Arg Glu Arg Asp Gly Ala Tyr Asp 
                645                 650                 655     


Val Val Val Thr Gly His Asp Ala Ala Glu Leu Ala Glu Glu Leu Pro 
            660                 665                 670         


Leu Arg His Pro Lys Lys Ala Glu Ala Ala Ala Ser Met Ser Ser Gly 
        675                 680                 685             


Arg Arg Ser Ser Arg Phe Asp Arg Val Ser Arg Arg Phe Gly Arg Leu 
    690                 695                 700                 


Leu Arg Glu Val Arg Arg Lys Tyr Gly Val Arg Ala Ser Asp Leu Gly 
705                 710                 715                 720 


Ser Ser Ser Thr Ile Ser Gln Ile Glu Ser Gly Glu Arg Arg Ala Thr 
                725                 730                 735     


Arg Arg Leu Ala Leu Glu Ile Val Glu Arg Leu Glu Glu Val Val Gly 
            740                 745                 750         


Asp Val Glu Glu Val Arg Glu Leu Arg Glu Leu Ala Glu Gly Asn Tyr 
        755                 760                 765             


Val Leu Asp Glu Val Val Glu Val Glu Thr Val Glu Tyr Glu His Glu 
    770                 775                 780                 


Tyr Leu Tyr Asp Val Thr Val Val Pro Asp His Thr Leu Val Val Glu 
785                 790                 795                 800 


Asn Gly Ile Ile Thr Ser Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
                805                 810                 815     


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
            820                 825                 830         


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
        835                 840                 845             


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
    850                 855                 860                 


Asn Ala Glu Ala Ala Thr Arg 
865                 870     


<210>  364
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:MP-Be_gp51

<400>  364

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Ser Trp Thr Asn Ala Arg Ala Val Thr Arg Arg Gly Phe 
    290                 295                 300                 


Val His Val Asp Asp Leu Thr Thr Asp Asp Glu Val Met Ser Val Asp 
305                 310                 315                 320 


Asp Gln Gly Arg Thr Ile Trp Gln Gln Ile Asp Glu Val Val Arg Phe 
                325                 330                 335     


Pro Phe Ser Gly Thr Leu Tyr Ser Leu Gly Gly Arg Glu Ile Asn Ala 
            340                 345                 350         


Thr Ile Thr Ala Asn His Arg Val Val Gly Leu Asn Arg Glu Lys Thr 
        355                 360                 365             


Lys Trp Val Glu His Thr Pro Thr Ser Leu Pro Gly Asn Lys Met Trp 
    370                 375                 380                 


Val Tyr Thr Ala Gly Glu Gly Ser Asn Glu Asp Tyr Pro Leu Thr Asp 
385                 390                 395                 400 


Thr Glu Ile Arg Leu Ala Val Trp Gly Leu Thr Asp Ser His Arg Ser 
                405                 410                 415     


Pro Asp Gly Arg Trp Thr Phe Tyr Gln Ser Gly Glu Lys Ala Glu Gln 
            420                 425                 430         


Val Arg Lys Leu Leu Ala Asp Ala Gly Ile Glu Tyr Arg Glu Arg Ala 
        435                 440                 445             


Arg Asn Arg Gly Ile Thr Glu Ile Asp Gly Lys Val Leu Lys Ala Pro 
    450                 455                 460                 


Pro Lys Thr Gln Tyr Glu Phe Ser Leu Gly Lys Val Gln Glu Leu Asp 
465                 470                 475                 480 


Asp Leu Leu Asp Arg Gly Arg Ser Glu Leu Pro Thr Trp Thr Leu Ser 
                485                 490                 495     


Leu Ser Gln Arg Gln Ala Arg Leu Phe Leu Glu Glu Tyr Arg Phe Thr 
            500                 505                 510         


Asp Gly Thr Asp Thr Thr Ser Ala Gly Asp Ser Tyr Val Leu Tyr Val 
        515                 520                 525             


Cys Lys Asp Arg Met Arg Glu Gln Leu Gln Met Leu Ala Ala Ala Asn 
    530                 535                 540                 


Gly Leu Arg Ala Ser Thr Thr Glu Tyr Arg Pro Gly His Trp Arg Leu 
545                 550                 555                 560 


Asn Ile Ser Asn Arg Ala Leu Ser Gly Leu Tyr Lys Asn Thr Val Glu 
                565                 570                 575     


Glu Val Ala Tyr Glu Gly Glu Val Trp Cys Leu Arg Val Pro Asn Gly 
            580                 585                 590         


Arg Phe Phe Ile Glu Asp Gly Gly Lys Ile His Leu Thr Gly Asn Ser 
        595                 600                 605             


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
    610                 615                 620                 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
625                 630                 635                 640 


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
                645                 650                 655     


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            660                 665                 670     


<210>  365
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:MP-Catera_gp206

<400>  365

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Leu Ala Cys Ser Thr Pro Ile Leu Thr Thr Asn Gly Trp 
    290                 295                 300                 


Ser Thr Met Gly Ala Leu Gln Asp Gly Asp Glu Val Tyr Ala Pro Asp 
305                 310                 315                 320 


Gly Gln Pro Thr Lys Val Ile Lys Ala His Pro Ile Asn Leu Asn Arg 
                325                 330                 335     


Pro Cys Phe Lys Val Arg Phe Arg Asp Gly Gln Glu Val Val Thr Asp 
            340                 345                 350         


Ala Glu His Leu Trp Gln Val Asn Asp Arg Asn Asn Gly Gly Arg Asp 
        355                 360                 365             


Arg Val Met Thr Thr Gln Glu Ile Ala Asp Ala Pro Trp Gly Gly Arg 
    370                 375                 380                 


Tyr Arg Phe Arg Val Pro Val Thr Glu Pro Leu Gln Thr Pro Glu Ala 
385                 390                 395                 400 


Asp Leu Pro Val Asp Pro Trp Leu Leu Gly Ala Trp Leu Gly Asp Gly 
                405                 410                 415     


Asp Ala Ser Met Val Ser Ile Cys Ser Gly Ser Gln Asp Leu Asp Tyr 
            420                 425                 430         


Leu Ile Ser Arg Val Glu Gly Leu Gly Leu Ser His Arg Val Asn Arg 
        435                 440                 445             


Tyr Gly Ser Arg Ala Ala Ser Val Tyr Val His Gly Met Arg Ala Val 
    450                 455                 460                 


Phe Ser Glu Leu Gly Leu Leu Lys Asn Lys His Ile Pro Asp Arg Tyr 
465                 470                 475                 480 


Leu Thr Ala Ser Val Ala Gln Arg Arg Gln Leu Leu Ala Gly Leu Met 
                485                 490                 495     


Asp Ser Asp Gly Thr Val Ser Asp Arg Gln Val Thr Ile Ser Met Lys 
            500                 505                 510         


Asn Glu Arg Leu Met Arg Gln Val Leu Gln Leu Val Arg Ser Leu Gly 
        515                 520                 525             


Tyr Arg Ala Gly Phe Gly Ser Arg Met Ala Arg Leu Asn Gly Arg Asp 
    530                 535                 540                 


Cys Gly Leu Val Tyr Val Val Arg Phe His Thr Gly Trp Gly Glu Ser 
545                 550                 555                 560 


Pro Phe Asp Met Pro Arg Lys Arg Asp Gly Trp Glu Gln Ala Thr Lys 
                565                 570                 575     


Thr Ser Val Gln Asn Leu Arg Leu Asn Ala Ile Val Ala Val Glu Pro 
            580                 585                 590         


Val Glu Thr Val Pro Val Arg Cys Ile Thr Val Ala His Glu Ser Ser 
        595                 600                 605             


Leu Tyr Val Ala Gly Glu Gly Phe Val Pro Thr His Ser Thr Tyr Ala 
    610                 615                 620                 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
625                 630                 635                 640 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
                645                 650                 655     


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
            660                 665                 670         


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680                 


<210>  366
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mxa_RAD25

<400>  366

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Lys Asn Asp Ser Leu Ile Phe Thr Asp Arg Gly Leu 
    290                 295                 300                 


Val Thr Ala Ala Glu Leu Ala Val Gly Val Pro Glu Glu His Ala Ala 
305                 310                 315                 320 


Phe Thr Glu Val Gly Val Asp Thr Ser Thr Gly Arg Ala Thr Thr Asn 
                325                 330                 335     


Ala Val Tyr Asn Gly Gly Arg Ser Pro Thr Lys Arg Ala Arg Leu Ala 
            340                 345                 350         


Leu Gly Tyr Glu Leu Glu Ala Thr Pro Glu His Pro Ile Arg Val Leu 
        355                 360                 365             


Arg Asp Asp Ala Leu Ala Trp Val Arg Met Asp Glu Leu His Val Gly 
    370                 375                 380                 


Asp Arg Val Ala Leu Arg Arg Gly Ser Glu Val Trp Gly Arg Ser Ser 
385                 390                 395                 400 


Leu Pro Glu Ala Phe Arg Trp Val Lys Pro Lys Tyr Ala Ala Asn Leu 
                405                 410                 415     


Lys Leu Pro Lys Gly Leu Val Leu Asp Glu Val Ala Ala Glu Ala Cys 
            420                 425                 430         


Gly Leu Leu Val Ser Glu Gly Thr Leu Thr Lys Arg Leu Val Thr Glu 
        435                 440                 445             


Phe Thr Asn Ala Asp Ala Asp Asn Val Gly Phe Ile Ser Arg Trp Ala 
    450                 455                 460                 


Ala Ser Ile Gly Ile Asp Leu Ser Arg Asn Gly Ser Asp Ser Ile Gln 
465                 470                 475                 480 


Tyr Leu Leu Cys Ser Val Val Leu Arg Glu Trp Leu Ala Trp Leu Gly 
                485                 490                 495     


Leu Asp Tyr Thr Arg Ala Ala Gly Lys Cys Ile Pro Arg Ala Val Arg 
            500                 505                 510         


Phe Gly Gly Arg Asp Ile Met Arg Ala Phe Leu Arg Gly Leu Phe Asp 
        515                 520                 525             


Gly Asp Ala Ser Val Asp Pro Leu Lys Gly Val Ile Glu Phe Cys Thr 
    530                 535                 540                 


Ala Ser Glu Arg Met Ala Arg Glu Val Gln Val Ala Leu Leu Gly Leu 
545                 550                 555                 560 


Gly Ile Leu Ala Ser Arg His Ser Arg Thr Val Ala Gly Tyr Glu Gln 
                565                 570                 575     


Leu Tyr Trp Arg Val Thr Val Asn Asp Val Ala Thr Phe Glu Arg Glu 
            580                 585                 590         


Val Gly Phe Ser Ser Asn Trp Asn Arg Leu Arg Leu Arg Glu Ala Val 
        595                 600                 605             


Ala Arg Ala Glu Gly Arg Cys Arg Asn Pro Asn Val Asp Thr Val Pro 
    610                 615                 620                 


Ile Asn Gly Leu Val Glu Arg Leu Tyr Arg Thr Ala Gln Lys Gln Leu 
625                 630                 635                 640 


Ser Trp Ser Ser Gln Glu Gly Arg Ile Phe Gly Asn Tyr Val His Gly 
                645                 650                 655     


Glu His Ala Pro Ser Arg Ala Ala Leu Glu Arg Met Val Gln Arg Trp 
            660                 665                 670         


Gly Ser Glu Cys Pro Thr Glu Cys Leu Pro Ile Glu Ala Phe Leu Glu 
        675                 680                 685             


Leu Pro Val Ala Phe Leu Ser Val Glu Ser Ile Glu Asp Gly Glu Ala 
    690                 695                 700                 


Asp Val Val Asp Leu Ser Val Pro Glu Thr His Glu Phe Val Ala Asn 
705                 710                 715                 720 


Gly Val Val Cys His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
                725                 730                 735     


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
            740                 745                 750         


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
        755                 760                 765             


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
    770                 775                 780                 


Ala Glu Ala Ala Thr Arg 
785                 790 


<210>  367
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Nfa_DnaB

<400>  367

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Pro Ala Ser Thr Arg Ile Leu Arg Ala Asp Thr Gly 
    290                 295                 300                 


Ala Glu Ser Thr Leu Gly Glu Leu Leu Ala Ser Gly Glu Gln Pro Leu 
305                 310                 315                 320 


Val Trp Ser Leu Asp Glu Arg Met Arg Met Val Ala Arg Pro Met Val 
                325                 330                 335     


Lys Val Phe Pro Ser Gly Arg Lys Glu Val Phe Arg Leu Arg Leu Ala 
            340                 345                 350         


Ser Gly Arg Glu Val Glu Ala Thr Gly Asn His Pro Phe Leu Thr Val 
        355                 360                 365             


Asp Gly Trp Ile Pro Leu Asp Arg Leu Thr Val Gly Asp Arg Leu Ala 
    370                 375                 380                 


Thr Pro Arg Ser Val Pro Glu Pro Val His Thr Glu Arg Met Ala Asp 
385                 390                 395                 400 


Ala Glu Val Val Leu Leu Ala His Met Ile Gly Asp Gly Ser Cys Val 
                405                 410                 415     


Arg Arg Gln Pro Val Arg Tyr Ala Ser Ile Asp Glu Gln Asn Leu Ala 
            420                 425                 430         


Ala Val Ser Glu Ala Ala Glu His Phe Gly Val Thr Ala Val Arg Asp 
        435                 440                 445             


Asp Tyr Ala Ala Ala Arg Val Thr Thr Leu Arg Leu Pro Ala Pro Tyr 
    450                 455                 460                 


Arg Leu Ser Arg Gly Lys Arg Asn Pro Ile Ala Ala Trp Leu Asp Glu 
465                 470                 475                 480 


Leu Gly Leu Phe Gly Leu Arg Ser His Glu Lys Phe Ile Pro Arg Arg 
                485                 490                 495     


Val Phe Ala Leu Pro Asn Asp Gln Val Ala Leu Phe Leu Arg His Leu 
            500                 505                 510         


Trp Ala Thr Asp Gly Ser Val Arg Trp Asp Ser Thr Tyr Arg Gln Ala 
        515                 520                 525             


Arg Val Tyr Tyr Thr Ser Thr Ser Arg Arg Leu Ile Asp Asp Val Ala 
    530                 535                 540                 


Gln Leu Leu Leu Arg Leu Gly Val His Gly Arg Ile Arg Arg Val Thr 
545                 550                 555                 560 


Lys Pro Gly Tyr Arg Asp Ala Trp His Leu Thr Ile Asp Gly Ala Asp 
                565                 570                 575     


Asn Gln Thr Val Phe Leu Arg Asp Val Gly Val His Gly Ala Arg Gly 
            580                 585                 590         


Asp Ala Ala Gln Val Ala Leu Ala Glu Leu Glu Pro Leu Val Arg Asn 
        595                 600                 605             


Thr Asn Val Asp Thr Val Pro Asn Glu Val Trp Asn Gln Val Arg His 
    610                 615                 620                 


Leu Leu Ala Thr Lys Asn Ile Thr His Arg Glu Phe Ser Ala Ala Met 
625                 630                 635                 640 


Gly Ser Arg Phe Cys Gly Ser Thr Met Trp Lys Arg Ser Pro Ser Arg 
                645                 650                 655     


Ser Arg Leu Ala Arg Val Ala Ala Val Leu Asp Asp Ala Asp Ile Glu 
            660                 665                 670         


Met Tyr Ala Thr Asn Asp Val Phe Trp Asp Lys Ile Val Glu Ile Thr 
        675                 680                 685             


Ser Leu Gly Glu Gln Asp Val Tyr Asp Gly Thr Val Pro Gly Thr His 
    690                 695                 700                 


Asn Phe Val Ala Gln Ser Ile Ser Val His Asn Ser Thr Tyr Ala Ser 
705                 710                 715                 720 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
                725                 730                 735     


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
            740                 745                 750         


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
        755                 760                 765             


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 


<210>  368
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Nfa_Nfa15250

<400>  368

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Pro Ala Gly Thr Val Val Ser Gly Pro Ser Ala Glu 
    290                 295                 300                 


Ala Ala Thr Arg Arg Trp Phe Glu Gly Glu Leu Val Val Phe Thr Thr 
305                 310                 315                 320 


Ala Ser Gly Lys Gln Leu Ser Leu Thr Gly Asn His Pro Val Leu Thr 
                325                 330                 335     


Arg Gly Gly Trp Val Pro Ala Asn Leu Leu Asn Glu Gly Asp Glu Val 
            340                 345                 350         


Val Arg Ser Thr Arg Pro Gln Gly Ala Thr Pro Leu Val Val Pro Asp 
        355                 360                 365             


His His Gln Val Pro Ala Leu Ile Glu Asp Val Trp Gly Ser Phe Ala 
    370                 375                 380                 


Val Asn Gly Leu His Arg Val Pro Ala Ala Pro Glu Asp Phe His Gly 
385                 390                 395                 400 


Asp Gly Gln Arg Gly Glu Val Asp Ile Val Gly Pro Asp Arg Thr Leu 
                405                 410                 415     


Trp Cys Gly His Asp Ala Ala Ile Ala Gln Gln Arg Glu Gln Gln Phe 
            420                 425                 430         


Phe Thr Arg Arg Thr Glu Ser Ser Gly Leu Leu Val Ala Glu Ser Val 
        435                 440                 445             


Ala Gln Leu Val Asp Leu Trp Gln Ala Pro His Ser Gly Ser Ser Ile 
    450                 455                 460                 


Gly Arg Ser Gly Leu Pro Phe Ala Leu Ile Gly Gly His Gly Gly Gly 
465                 470                 475                 480 


Pro Val Glu Arg Gly Leu Thr Val Ala Ala Gly Gly Tyr Pro Gly Leu 
                485                 490                 495     


His Glu Ala Leu Ala Asp Tyr Arg Pro Gly Asp Ala Val Leu Pro Pro 
            500                 505                 510         


Gln Gly Val Phe Ala Gly Ser Ser Glu Ile Gly Gly Asp Asp Cys Val 
        515                 520                 525             


Ile Gly Lys Val Asp Ser Thr Arg Trp Asp Ala Pro Ala Leu Pro Phe 
    530                 535                 540                 


Leu Val Glu Gly Arg Ala Gly Tyr Ala Ser Arg Gly Lys Glu Leu Phe 
545                 550                 555                 560 


Asp Arg Leu Thr Gly Gln Val Glu Leu Asp Arg Ile Val Ile Leu Arg 
                565                 570                 575     


Arg Val Gln Trp Ser Gly His Val Phe Ser Leu Thr Ser Ser Glu Gly 
            580                 585                 590         


Trp His Thr Gly Asn Ser Leu Ile Val Ser Asn Ser Thr Tyr Ala Ser 
        595                 600                 605             


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
    610                 615                 620                 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
625                 630                 635                 640 


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
                645                 650                 655     


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            660                 665         


<210>  369
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Nfa_RIR1

<400>  369

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Pro Ala Gly Thr Pro Val Asp Thr Ile Asp Gly Pro 
    290                 295                 300                 


Lys Pro Ile Glu Ser Leu Arg Ala Gly Asp Arg Val Leu Ser His Asp 
305                 310                 315                 320 


Gly Ser Tyr Ala Thr Val Glu Lys Leu Ile Glu Asn Thr Asn Asp Gln 
                325                 330                 335     


Pro Leu Val Ser Ile Ser His Phe Gly His Lys Glu Pro Ile Arg Cys 
            340                 345                 350         


Thr Pro Glu His Pro Ile Leu Val Trp Thr Asp Arg Asp Val Glu Thr 
        355                 360                 365             


Leu Ile Asp Gly Asp Gly Ala Asp Pro Phe Asn Gly Phe Val Trp Leu 
    370                 375                 380                 


Ala Ala Gln Asp Val His Pro Ser Asp Phe Ile Val Ala Thr Ala Pro 
385                 390                 395                 400 


Leu Glu Thr Arg Glu Arg Arg Val Phe Asp Leu Met Asn His Val Gly 
                405                 410                 415     


Glu Gly Thr Tyr Glu Glu Val Asp Gly Leu Ile Arg Lys Val Asn Thr 
            420                 425                 430         


Asp Ala Arg His Arg Asn Lys Gln Arg His Arg Gln Gly Phe Val Ala 
        435                 440                 445             


Val Thr Arg Tyr Val Glu Glu Ser Tyr Asp Leu Gly Leu Ile Leu Gly 
    450                 455                 460                 


Trp Tyr Leu Ala Glu Gly His Val Ser Lys Arg Ser Gly Val Glu Asp 
465                 470                 475                 480 


Val Arg Pro Thr Gly Val His Phe Thr Leu Gly Ala Asn Glu Ile Glu 
                485                 490                 495     


Arg His Val Glu Leu Gly Met Ala Phe Lys Gln Val Phe Gly Val Asp 
            500                 505                 510         


Leu Val Leu His Thr Asn His Ser Asp His Ser Thr Arg Met Val Cys 
        515                 520                 525             


Asn Ser Lys Ile Val Ala Ser Leu Leu Leu Ser Leu Ala Gly Thr Gly 
    530                 535                 540                 


Tyr Ser Thr Lys Arg Leu Ala His Glu Val Met Thr Ala Asp Glu Asp 
545                 550                 555                 560 


Phe Gln Arg Gly Leu Leu Val Gly Leu Phe Arg Gly Asp Gly Cys Thr 
                565                 570                 575     


Thr Thr Gly Gly Met Val Leu Asp Leu Val Asn Gln Glu Leu Ile Asp 
            580                 585                 590         


Gln Val Gln Leu Leu Leu Arg Arg Leu Gly Ile Val Ser Val Val Arg 
        595                 600                 605             


Thr Tyr Thr Asn Gln Ala Gly Asn Pro Thr Gly Gln Val Phe Val Pro 
    610                 615                 620                 


Gly Leu Pro Gly Thr Asn Glu Glu Phe Ile Phe Asp Val Asp Lys Asn 
625                 630                 635                 640 


Leu Gln Asn Tyr Thr Gly Arg Lys Gly Thr Lys Arg Thr Thr Tyr Gln 
                645                 650                 655     


Val Val His Gly Arg His Val Tyr Gly Ile Arg Ala Val Glu Arg Thr 
            660                 665                 670         


Gly Glu Thr Pro Arg Gln Val Tyr Asn Leu His Val Glu Gly Thr His 
        675                 680                 685             


Thr Tyr Thr Ile Arg Gly Ala Val Val His Asn Ser Thr Tyr Ala Ser 
    690                 695                 700                 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
705                 710                 715                 720 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
                725                 730                 735     


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
            740                 745                 750         


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760             


<210>  370
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Nph_CDC21

<400>  370

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Asp Gly Asp Thr Ser Val Thr Leu Ala Ser Gly Asp 
    290                 295                 300                 


Glu Lys Pro Ile Arg Asp Ile Val Glu Ser Thr Leu Glu Asp Pro Thr 
305                 310                 315                 320 


Glu Ile Ser Asp Gly Phe Tyr Gln Glu Ser Asp Ile Asp Val Leu Thr 
                325                 330                 335     


Thr Asp Gly Gly Ala Val Ala Pro Gly Arg Ala Thr Lys Val Trp Lys 
            340                 345                 350         


Arg Gln Ala Pro Glu Lys Met Tyr Arg Ile Arg Thr Glu Ser Gly Arg 
        355                 360                 365             


Glu Leu Glu Val Thr Pro Ser His Pro Leu Phe Val Gln Ser Glu Gly 
    370                 375                 380                 


Gly Leu Ser Pro Leu Val Ala Asp Asp Leu Ser Glu Asn Asp Phe Val 
385                 390                 395                 400 


Ala Val Pro Arg Ala Leu Pro Ala Asp Asp Gly Asp Asp Phe Gly Gln 
                405                 410                 415     


His Val Asp Asp Leu Gly Ser Val Thr Ala Arg Lys Thr Ala Asp Ala 
            420                 425                 430         


Glu Ala Val Arg Ser Glu Asp Ala Ala Thr Thr Pro Asp Val Ile Pro 
        435                 440                 445             


Asn Val Gly Asp Gln Leu Arg Arg Ile Arg Thr Ser Leu Arg Leu Ser 
    450                 455                 460                 


Gln His Asp Cys Gly Leu Pro Arg Ser Thr Tyr Gln Gln Tyr Glu Arg 
465                 470                 475                 480 


Gly Asp Arg Asn Pro Ser Arg Ser Arg Leu Gln Thr Val Leu Thr Ala 
                485                 490                 495     


Phe Glu Arg Arg Ile Glu Gln Leu Ser Ser Leu Ser Asp Arg Val Asp 
            500                 505                 510         


Asp Gly Asp Ser Asp Ala Ile Ala Ala Ala Arg Asp Glu Leu Asn Pro 
        515                 520                 525             


Ser Gln Ala Ser Leu Ala Ser Gly Met Asp Ala Thr Arg Thr Ala Ile 
    530                 535                 540                 


Gly Asp Asp Glu Arg Thr Glu Ala Arg Pro Asp Gly Gly Ala Val Ala 
545                 550                 555                 560 


Asp Ala Glu Arg Ala Val Ala Asp Ala Leu Cys Arg Ala Leu Ala Val 
                565                 570                 575     


Ala Asp Asp Val Glu Arg Leu Arg Ser Leu Ala Asp Gly Asp Ile Gly 
            580                 585                 590         


Trp Asp Arg Ile Asp Ser Ile Glu Pro Val Glu Pro Glu Asp Glu Trp 
        595                 600                 605             


Val Tyr Asp Leu Glu Val Glu Ser Thr His Ser Tyr Leu Ser Asn Asp 
    610                 615                 620                 


Val Val Ser His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
625                 630                 635                 640 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                645                 650                 655     


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            660                 665                 670         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        675                 680                 685             


Glu Ala Ala Thr Arg 
    690             


<210>  371
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Nph_rPol_App

<400>  371

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Ile Pro Ala Asp Glu Gln Val Val Val Arg Arg Asn Gly 
    290                 295                 300                 


Glu Thr Glu Leu Thr Glu Ile Gly Pro Leu Val Asp Ser Leu Met Asp 
305                 310                 315                 320 


Ser Arg Glu Thr Arg Ser Phe Asp Asp His Glu Val Thr Leu Ala Pro 
                325                 330                 335     


Asp Gly Ile Glu Val Pro Ser Leu Ser Ser Glu Glu Thr Val Glu Trp 
            340                 345                 350         


Lys Pro Ile Glu Glu Val Ser Arg His Glu Thr Pro Asp Glu Leu Leu 
        355                 360                 365             


Arg Phe Glu Leu Glu Ser Gly Arg Ser Ile Arg Ala Thr Lys Ala His 
    370                 375                 380                 


Ser Phe Val Thr Arg Gln Glu Asn Glu Val Val Pro Val Ala Gly Glu 
385                 390                 395                 400 


Glu Leu Glu Ala Gly Asp Trp Leu Pro Val Val Ala Ser Leu Asp Ala 
                405                 410                 415     


Thr Asp Thr Gln Glu Thr Val Asp Leu Arg Lys Tyr Leu Pro Ala Gly 
            420                 425                 430         


Asp Tyr Trp Tyr Thr Ser Val Leu Ala Asp Gly Gly Ala Glu Ala Val 
        435                 440                 445             


Pro Gly Gly Pro Asp Gln Leu Arg Asn Lys Arg Ala Ala Leu Glu Ala 
    450                 455                 460                 


Gly Glu Leu Ala Glu His Thr Ala Tyr Pro Val Gln Gly Thr Val Gly 
465                 470                 475                 480 


Leu Pro Glu Gln Phe Pro Leu Asp Glu Glu Thr Gly Phe Phe Val Gly 
                485                 490                 495     


Ala Trp Leu Ala Glu Gly Ser Leu Ala Asp His Tyr Val Ser Ile Ser 
            500                 505                 510         


Asn Val Asp Ala Ala Phe Gln Ser Arg Ile Arg Ser Phe Ala Glu Arg 
        515                 520                 525             


Phe Asp Leu Thr Val Asn Glu Tyr Glu Asn Asp Ser Gly Phe Ala Ala 
    530                 535                 540                 


Gly Tyr Asp Ile Arg Leu Asn Gly Thr Ile Leu Ser Asp Phe Leu Arg 
545                 550                 555                 560 


Ala Ala Cys Thr Asp Asp Gly Glu Lys Ser Ile Pro Gly Phe Ala Ile 
                565                 570                 575     


Gly Ala Asn Glu Ala Phe Leu Lys Gly Leu Leu Gln Gly Tyr Phe Ser 
            580                 585                 590         


Gly Asp Gly Asn Val Gly Thr Asn Ala Ile Arg Ser Ser Ser Thr Ser 
        595                 600                 605             


Asp Arg Leu Thr Ala Gly Val Gly Leu Leu Leu Ala Arg Phe Asp Val 
    610                 615                 620                 


Tyr Ala Thr Leu Gly Gln Gln Glu Asp Ser Arg Thr Leu Arg Val Pro 
625                 630                 635                 640 


Lys Lys His Val Ser Arg Phe Asp Asn Arg Ile Gly Met Val Gly Glu 
                645                 650                 655     


Arg Gly Ala Glu Leu Glu Ala Leu Ala Glu Ser Ala Asp Ser Asp Gly 
            660                 665                 670         


Pro Asp Ala Thr Asp Gln Ile Pro Asn Phe Gly Asp Ala Leu Glu Ala 
        675                 680                 685             


Val Ala Glu Ala Ala Asp Ile Pro Gln Arg Gln Val Asn Ser Ala Thr 
    690                 695                 700                 


Lys Arg Gln Arg Ile Asp Arg Ser Arg Leu Ala Arg Leu Val Ala Ala 
705                 710                 715                 720 


Ala Glu Ala Glu Leu Asp Gly Glu Gln Ser Glu Leu Asp Ala Leu Arg 
                725                 730                 735     


Gln Ala Val Thr Gly Asp Val Val Trp Asp Arg Ile Glu Ser Ile Glu 
            740                 745                 750         


Thr Val Glu Ser Asp His Glu Tyr Val Tyr Asp Val Ser Val Glu Gly 
        755                 760                 765             


Leu Glu Thr Phe Thr Thr Ala Asp Gly Val Val Thr His Asn Ser Thr 
    770                 775                 780                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
785                 790                 795                 800 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                805                 810                 815     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            820                 825                 830         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840                 845     


<210>  372
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Npu_GyrB

<400>  372

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ile Gly Asp Thr Leu Ile Pro Leu Ala Asp Gly Lys 
    290                 295                 300                 


Ser Tyr Arg Ile Lys Asp Leu Met Asp Trp Gly Thr Glu Phe Ile Val 
305                 310                 315                 320 


Tyr Ala Cys Thr Pro Thr Gly Lys Ile Val Ala Ala Gln Ala Thr Ala 
                325                 330                 335     


Lys Leu Thr Arg Arg Asn Ala Pro Leu Val Lys Val Ile Leu Asp Asn 
            340                 345                 350         


Gly Glu Glu Ile Ile Cys Thr Pro Asp His Gln Phe Met Leu Arg Asp 
        355                 360                 365             


Gly Thr Tyr Lys Glu Ala Gln Leu Leu Gln Ala Glu Thr Ser Leu Met 
    370                 375                 380                 


Pro Phe Tyr Ser Lys Thr Asp Lys Asp Gly Tyr Thr Leu Ile Thr Gln 
385                 390                 395                 400 


Pro Tyr Ser Ser Arg Trp Gln Lys Ala His Trp Ile Ile Ala Arg Ser 
                405                 410                 415     


Gly Leu Leu Gly Lys Val Pro Arg Phe Glu Gly Gln Lys Thr Phe Ile 
            420                 425                 430         


His His Gln Asn Phe Asp Glu Ser Asp Asn Arg Pro Glu Asn Leu Glu 
        435                 440                 445             


Phe Met Gly Asn Arg Asp His Ser Ala Tyr His Arg Ser Leu Val Glu 
    450                 455                 460                 


Arg Asn Gln His Trp His Ser Ala Glu Phe Glu Glu Lys Arg Val Ala 
465                 470                 475                 480 


Ser Leu Ala Gln Lys Ala Lys Thr Ser Glu Gly Tyr Gln Tyr Tyr Ala 
                485                 490                 495     


Glu Arg Gly Thr Arg Asn Ile Phe Gln Tyr Met Glu Gln Gln Pro Glu 
            500                 505                 510         


His Phe Lys Asn Ala Val Ala Gly Asn Gly Asn Arg Gly Lys Gln Tyr 
        515                 520                 525             


Leu Val Glu Tyr Asn Lys Thr Glu Lys Gly Arg Gly Lys Ser Gln Glu 
    530                 535                 540                 


Ile Ala Asn Arg Tyr Tyr Thr Cys Glu Ile Cys Gly Val Asp Val Lys 
545                 550                 555                 560 


Thr Pro Ile Gly Leu His Asn His Arg Arg Lys Glu His Gln Cys Asn 
                565                 570                 575     


His Lys Val Val Ala Val Asn Leu Leu Asn Tyr Thr Glu Asp Val Tyr 
            580                 585                 590         


Cys Leu Thr Val Pro Glu Tyr His Asn Phe Ala Leu Lys Ala Gly Val 
        595                 600                 605             


Phe Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
    610                 615                 620                 


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
625                 630                 635                 640 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
                645                 650                 655     


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
            660                 665                 670         


Ala Ala Thr Arg 
        675     


<210>  373
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Nsp-JS614_DnaB

<400>  373

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ala Leu Ala Leu Asp Thr Ala Leu Pro Thr Pro Ser Gly Trp 
    290                 295                 300                 


Thr Thr Met Gly Asp Val Gln Val Gly Asp Gln Leu Tyr Asp Ala His 
305                 310                 315                 320 


Gly Arg Pro Thr Thr Val Val Ala Ala Thr Glu Val Leu Thr Gly Arg 
                325                 330                 335     


Pro Cys Tyr Glu Val Glu Phe Ser Asp Gly Ser Arg Ile Val Ala Asp 
            340                 345                 350         


Ala Gln His Gln Trp Leu Thr Glu Ser Arg Ala Ala Arg Lys Ser Arg 
        355                 360                 365             


Trp Ala Ala Asp Lys Gln Tyr Asn Arg Ala Arg Asn Gln Asn Ile Val 
    370                 375                 380                 


Ala Ser Val Val Thr Thr Glu Ala Ile Ala Gly Thr Leu Arg Val Gly 
385                 390                 395                 400 


Ala Asp Gln Arg Ala Asn His Ala Val Leu Thr Ala Asp Pro Leu Ser 
                405                 410                 415     


Gly Ser Asp Val Asp Leu Pro Ile Pro Pro Tyr Val Leu Gly Ala Trp 
            420                 425                 430         


Leu Gly Asp Gly His Ser Ala Ser Ala Arg Ile Thr Cys Glu Thr Pro 
        435                 440                 445             


Glu Ile Pro Met Tyr Leu Glu Ala Cys Gly Leu Arg Val Asp His Gln 
    450                 455                 460                 


Gly Ala Met Leu Tyr Ser Leu Lys Phe Pro Asp Gly Asp Pro Arg Gly 
465                 470                 475                 480 


Ser Val Gln Gly Val Leu Arg Thr Ile Gly Val Leu Asn Asp Lys His 
                485                 490                 495     


Ile Pro Ala Asp Tyr Leu Arg Ala Ser Glu Gly Gln Arg Arg Asp Leu 
            500                 505                 510         


Leu Ala Gly Leu Met Asp Thr Asp Gly Thr Val Val Arg Gly Val Gly 
        515                 520                 525             


Ser Cys Gln Phe Ala Val Thr Asn Lys Arg Leu Ala Asp Asp Val Tyr 
    530                 535                 540                 


Glu Leu Val Val Ser Leu Gly Tyr Lys Cys Gly Arg Thr Thr Arg Arg 
545                 550                 555                 560 


Val Gln Gly Arg Ser Pro Glu Thr Ser Thr Cys His Ile Leu Asn Phe 
                565                 570                 575     


Ser Thr Val Asp Asp Val Phe Arg Leu Glu Arg Lys His Leu Leu His 
            580                 585                 590         


Lys Glu Glu Arg Pro Val Thr Arg Ala Arg Ile Ala Arg Arg Tyr Ile 
        595                 600                 605             


Thr Ala Val Arg Pro Ile Glu Ser Val Pro Val Arg Cys Val Glu Val 
    610                 615                 620                 


Asp Asn Thr Glu His Leu Tyr Leu Ala Gly Glu Ser Met Ile Pro Thr 
625                 630                 635                 640 


His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
                645                 650                 655     


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
            660                 665                 670         


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
        675                 680                 685             


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
    690                 695                 700                 


Thr Arg 
705     


<210>  374
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Nsp-PCC7120_RIR1

<400>  374

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Pro Glu Asp Ala Leu Val His Thr Ala Lys Gly Leu 
    290                 295                 300                 


Val Pro Ile Arg Asp Val Gln Val Gly Asp Leu Val Gln Thr Pro Leu 
305                 310                 315                 320 


Gly Phe Arg Arg Val Val Asp Lys Phe Asp Gln Gly Phe Gln Asp Val 
                325                 330                 335     


Tyr Glu Ile Glu Thr Asn Ala Thr Tyr Pro Arg Ala Thr Leu Asn His 
            340                 345                 350         


Arg Gln Ala Val Leu Glu Asp Ala Lys Gly Gly Ile Val Trp Lys His 
        355                 360                 365             


Ile Ala Ser Leu Glu Ala Gly Asp Arg Leu Leu His Asn Lys Gln Val 
    370                 375                 380                 


Leu Pro Gly Thr Val Thr His Leu Pro Ala Asp Phe Thr Glu Ser Arg 
385                 390                 395                 400 


Pro Ser His Ser Arg Thr Ala Lys Ser Phe Val Val Pro Glu Leu Thr 
                405                 410                 415     


Ala Glu Val Ala Trp Leu Ile Gly Phe Thr His Gly Asp Gly Tyr Val 
            420                 425                 430         


Ala Leu Gly Arg Asn Lys Tyr Asp Lys Pro Tyr Gly Arg Val Glu Trp 
        435                 440                 445             


Ser Met Asn Ser Leu Asp Ala Glu Val Thr Ser Arg Ile Gln Ala Lys 
    450                 455                 460                 


Ile Asp Ala Ala Leu Ala Leu Phe Gly Leu Ser Ala Val His Ser Ile 
465                 470                 475                 480 


Thr Lys Gly Glu Asn Thr Ala Lys Ser Ile Cys Ser Ser Ile Arg Leu 
                485                 490                 495     


Ala Glu Tyr Phe His Arg His Ile Lys Gln Pro Asn Ile Pro Leu Thr 
            500                 505                 510         


Val Pro Ser Phe Ile Leu Gln Gly Ser Val Asp Ile Arg Ala Ala Tyr 
        515                 520                 525             


Leu Ala Gly Leu Met Asp Ser Asp Gly Ala Val Asn Asn Arg Pro Pro 
    530                 535                 540                 


His Leu Ile Thr Ser Val Tyr Arg Ser Phe Ile Arg Gln Val Ser Val 
545                 550                 555                 560 


Val Leu Ser Ser Leu Gly Ile Ala Gly Arg Leu Thr Thr Thr Tyr Pro 
                565                 570                 575     


Gln Asn Ser Asn Trp Gln Val Lys Tyr Asn Leu Thr Ile Pro Ala Leu 
            580                 585                 590         


Lys Glu Arg Tyr Asn Ala Leu Ile Ser Pro His Ser Ala Lys Gly Glu 
        595                 600                 605             


Leu Arg Gln Gly Leu Lys Met Tyr Gly Phe Thr Val Pro Gly Ala Val 
    610                 615                 620                 


Met Arg Glu Thr Tyr Thr Tyr Ser Glu Met Arg Glu Met Gly Phe Gln 
625                 630                 635                 640 


Gly Ser Arg Thr Val Asp Ala Asn Tyr Glu Arg Tyr Val Ala Glu Ala 
                645                 650                 655     


Asp Ile Ser Leu Asp Ile Pro Val Thr Val Lys Gly Leu Gly Ser Tyr 
            660                 665                 670         


Asp His Val Gln Thr Tyr Asp Ile Glu Val Asp Glu Ala His Cys Phe 
        675                 680                 685             


Tyr Cys Asp Gly Tyr Leu Thr His Asn Ser Thr Tyr Ala Ser Leu Asn 
    690                 695                 700                 


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
705                 710                 715                 720 


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
                725                 730                 735     


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
            740                 745                 750         


Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760     


<210>  375
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_CDC21-1

<400>  375

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Asp Tyr Glu Thr Glu Val Val Leu Gly Asn Gly Glu 
    290                 295                 300                 


Arg Lys Lys Ile Gly Glu Ile Val Glu Arg Ala Ile Glu Glu Ala Glu 
305                 310                 315                 320 


Lys Asn Gly Lys Leu Gly Arg Val Asp Asp Gly Phe Tyr Ala Pro Ile 
                325                 330                 335     


Asp Ile Glu Val Tyr Ser Leu Asp Leu Glu Thr Leu Lys Val Arg Lys 
            340                 345                 350         


Ala Arg Ala Asn Ile Ala Trp Lys Arg Thr Ala Pro Lys Lys Met Met 
        355                 360                 365             


Leu Val Lys Thr Arg Gly Gly Lys Arg Ile Arg Val Thr Pro Thr His 
    370                 375                 380                 


Pro Phe Phe Val Leu Glu Glu Gly Lys Val Ala Met Arg Lys Ala Arg 
385                 390                 395                 400 


Asp Leu Glu Glu Gly Asn Lys Ile Ala Thr Ile Glu Gly Leu Ser Val 
                405                 410                 415     


Ser Trp Asp Glu Val Ala Glu Ile Leu Glu Tyr Glu Pro Lys Asp Pro 
            420                 425                 430         


Trp Val Tyr Asp Leu Gln Val Pro Gly Tyr His Asn Phe Leu Ala Asn 
        435                 440                 445             


Gly Ile Phe Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
    450                 455                 460                 


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
465                 470                 475                 480 


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
                485                 490                 495     


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
            500                 505                 510         


Ala Glu Ala Ala Thr Arg 
        515             


<210>  376
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_CDC21-2

<400>  376

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ala Pro Glu Thr Leu Ile Ile Thr Glu Asn Gly Thr 
    290                 295                 300                 


Lys Glu Ile Gly Glu Val Val Glu Arg Trp Met Lys Glu Leu Gly Glu 
305                 310                 315                 320 


Ile Glu Tyr Asp Asp Gly Ile Ser Tyr Ser Pro Ala Phe Glu Lys Val 
                325                 330                 335     


Ala Ser Leu Asn Gly Gly Lys Val Lys Met Leu Pro Val Arg Arg Val 
            340                 345                 350         


Trp Lys Leu Arg Ser Pro Gly Lys Met Ile Lys Ile Arg Ser Glu Ser 
        355                 360                 365             


Gly Lys Gln Ile Thr Val Thr Pro Glu Thr Lys Leu Leu Thr Ile Ile 
    370                 375                 380                 


Asp Gly Ser Leu Glu Trp Val Glu Ala Arg Lys Leu Lys Lys Gly Asn 
385                 390                 395                 400 


Tyr Val Ala Val Val Asn Lys Glu Arg Ser Ile Val Pro Ile Gly Asp 
                405                 410                 415     


Phe Leu Ala Lys Leu Leu Lys Phe Tyr Gly Val Glu Leu Asn Leu Asn 
            420                 425                 430         


Glu Ala Val Glu Arg Asp Gln Ala Arg Lys Leu Leu Glu Thr Leu Lys 
        435                 440                 445             


Ser Lys Gly Leu Ser Asp Val Thr Ile Glu Ile Pro Glu Lys Leu Arg 
    450                 455                 460                 


Arg Phe Ile Lys Cys Asp Arg Val Arg Tyr Val Asp Leu Val Glu Met 
465                 470                 475                 480 


Leu Ser Ser Met Glu Gly Glu Leu Lys Glu Glu Val Met Leu Leu Leu 
                485                 490                 495     


Ser Asp Val Gly Asp Ile His Glu Val Ile Gln Glu Arg Leu Lys Glu 
            500                 505                 510         


Ile Gly Lys Ile Leu Glu Ser Asp Ala Ser Trp Glu Arg Ile Ala Glu 
        515                 520                 525             


Val Glu Glu Val Val Arg Asp Gly His Val Tyr Asp Leu Thr Val Glu 
    530                 535                 540                 


Gly Ser His Ser Phe Ile Ala Asn Gly Phe Val Val His Asn Ser Thr 
545                 550                 555                 560 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
                565                 570                 575     


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
            580                 585                 590         


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
        595                 600                 605             


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    610                 615                 620         


<210>  377
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_IF2

<400>  377

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Leu Pro Asp Glu Lys Val Val Val Pro Ser Val Gly 
    290                 295                 300                 


Phe Val Thr Leu Lys Glu Leu Phe Glu Thr Ala Ser Lys Val Val Glu 
305                 310                 315                 320 


Arg Asp Asp Glu Lys Glu Ile Arg Glu Leu Asp Glu Arg Ile Thr Ser 
                325                 330                 335     


Val Asn Gly Asp Gly Lys Thr Gly Leu Val Lys Ala Ser Tyr Val Trp 
            340                 345                 350         


Lys Val Arg His Lys Gly Lys Val Ile Arg Val Lys Leu Lys Asn Trp 
        355                 360                 365             


His Gly Val Thr Val Thr Pro Glu His Pro Phe Leu Thr Thr Lys Gly 
    370                 375                 380                 


Trp Lys Arg Ala Asp Gln Leu Arg Pro Gly Asp Tyr Val Ala Val Pro 
385                 390                 395                 400 


Arg Phe Ile His Gly Asn Glu Asp Glu Lys Ile Phe Leu Ser Tyr Val 
                405                 410                 415     


Lys Val Lys Lys Ser Gly Glu Glu Trp Lys Glu Tyr Phe Tyr Leu Ala 
            420                 425                 430         


Gly Arg Lys Gly Asn Ile Asp Val Asn Leu Leu Phe Val Ala Pro Lys 
        435                 440                 445             


Arg Tyr Val Val Glu Phe Leu Arg Gly Tyr Phe Glu Glu Arg Ser Glu 
    450                 455                 460                 


Val Lys Gly Glu Ser Val Ile Val Glu Ala Arg Glu Leu Val Glu Pro 
465                 470                 475                 480 


Leu Ser Leu Ala Leu Leu Arg Phe Gly Ile Phe Ser Lys Ile Gln Gly 
                485                 490                 495     


Ser Lys Leu Ile Val Thr Gly Lys Arg Asn Leu Glu Ala Phe Lys Asp 
            500                 505                 510         


Tyr Ile Gly Phe Lys Asp Glu Arg Glu Lys Ala Leu Glu Glu Ala Ile 
        515                 520                 525             


Glu Lys Val Lys Gly Ser Glu Val Tyr Pro Ile Phe Glu Glu Ile Arg 
    530                 535                 540                 


Arg Leu Arg Leu Leu Phe Gly Phe Thr Arg Glu Glu Leu Gly Ser Tyr 
545                 550                 555                 560 


Ala Lys Tyr Glu Asn Ser Glu Ala Pro Thr Tyr Glu Glu Leu Met Glu 
                565                 570                 575     


Ile Leu Asp Phe Ile Glu Arg Gly Ser Pro Ser Leu Ser Lys Lys Ile 
            580                 585                 590         


Ala Ile Leu Glu Gly Lys Leu Lys Ala Glu Leu Arg Val Leu Glu Glu 
        595                 600                 605             


Glu Gly Leu Ile Lys Asp Gly Lys Leu Thr Pro Leu Gly Arg Glu Leu 
    610                 615                 620                 


Leu Glu Val Trp Arg Asn Arg Glu Phe Asp Ser Lys Asp Val Asp Tyr 
625                 630                 635                 640 


Ile Arg Asn Ile Ala Glu Thr Leu Val Phe Ile Pro Val Glu Asn Val 
                645                 650                 655     


Glu Glu Glu Glu Tyr Asp Gly Tyr Val Tyr Asp Leu Thr Thr Glu Thr 
            660                 665                 670         


His Asn Phe Ile Ala Asn Gly Ile Leu Val His Asn Ser Thr Tyr Ala 
        675                 680                 685             


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
    690                 695                 700                 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
705                 710                 715                 720 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
                725                 730                 735     


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            740                 745             


<210>  378
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_KlbA

<400>  378

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ala Leu Tyr Tyr Phe Ser Glu Ile Gln Leu Pro Asn Gly Lys 
    290                 295                 300                 


Glu Phe Ile Gly Lys Leu Val Asp Glu Leu Phe Glu Lys Tyr His Asp 
305                 310                 315                 320 


Lys Ile Gly Lys Tyr Lys Asp Met Glu Tyr Val Glu Leu Asn Glu Glu 
                325                 330                 335     


Asp Thr Phe Glu Val Ile Ser Ile Gly Pro Asp Leu Ser Ala Arg Arg 
            340                 345                 350         


His Lys Val Thr His Val Trp Arg Arg Lys Val Lys Asp Gly Glu Lys 
        355                 360                 365             


Leu Val Lys Ile Arg Thr Ala Ser Gly Lys Glu Leu Val Leu Thr Gln 
    370                 375                 380                 


Asp His Pro Val Phe Val Leu Leu Gly Arg Asp Val Ala Arg Arg Asp 
385                 390                 395                 400 


Ala Gly Asn Val Lys Val Gly Asp Glu Ile Ala Val Leu Asn Thr Arg 
                405                 410                 415     


Pro Asp Phe Ser Val Leu Ser Pro Pro Ala Met Pro Glu Leu Leu Ser 
            420                 425                 430         


Glu Pro Phe Asn Tyr Glu Leu Ser Ser Ile Gly Asp Val Ala Trp Asp 
        435                 440                 445             


Glu Val Val Glu Val Asp Glu Ile Asp Ala Lys Gly Leu Gly Val Glu 
    450                 455                 460                 


Tyr Leu Tyr Asp Leu Thr Val Asp Ile Asn His Asn Tyr Val Ala Asn 
465                 470                 475                 480 


Gly Ile Val Val Ser Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
                485                 490                 495     


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
            500                 505                 510         


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
        515                 520                 525             


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
    530                 535                 540                 


Ala Glu Ala Ala Thr Arg 
545                 550 


<210>  379
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_Lon

<400>  379

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ser Gly Glu Glu Thr Val Val Ile Arg Glu Asn Gly 
    290                 295                 300                 


Glu Val Lys Val Leu Arg Leu Lys Asp Phe Val Glu Lys Ala Leu Glu 
305                 310                 315                 320 


Lys Pro Ser Gly Glu Gly Leu Asp Gly Asp Val Lys Val Val Tyr His 
                325                 330                 335     


Asp Phe Arg Asn Glu Asn Val Glu Val Leu Thr Lys Asp Gly Phe Thr 
            340                 345                 350         


Lys Leu Leu Tyr Ala Asn Lys Arg Ile Gly Lys Gln Lys Leu Arg Arg 
        355                 360                 365             


Val Val Asn Leu Glu Lys Asp Tyr Trp Phe Ala Leu Thr Pro Asp His 
    370                 375                 380                 


Lys Val Tyr Thr Thr Asp Gly Leu Lys Glu Ala Gly Glu Ile Thr Glu 
385                 390                 395                 400 


Lys Asp Glu Leu Ile Ser Val Pro Ile Thr Val Phe Asp Cys Glu Asp 
                405                 410                 415     


Glu Asp Leu Lys Lys Ile Gly Leu Leu Pro Leu Thr Ser Asp Asp Glu 
            420                 425                 430         


Arg Leu Arg Lys Ile Ala Thr Leu Met Gly Ile Leu Phe Asn Gly Gly 
        435                 440                 445             


Ser Ile Asp Glu Gly Leu Gly Val Leu Thr Leu Lys Ser Glu Arg Ser 
    450                 455                 460                 


Val Ile Glu Lys Phe Val Ile Thr Leu Lys Glu Leu Phe Gly Lys Phe 
465                 470                 475                 480 


Glu Tyr Glu Ile Ile Lys Glu Glu Asn Thr Ile Leu Lys Thr Arg Asp 
                485                 490                 495     


Pro Arg Ile Ile Lys Phe Leu Val Gly Leu Gly Ala Pro Ile Glu Gly 
            500                 505                 510         


Lys Asp Leu Lys Met Pro Trp Trp Val Lys Leu Lys Pro Ser Leu Phe 
        515                 520                 525             


Leu Ala Phe Leu Glu Gly Phe Arg Ala His Ile Val Glu Gln Leu Val 
    530                 535                 540                 


Asp Asp Pro Asn Lys Asn Leu Pro Phe Phe Gln Glu Leu Ser Trp Tyr 
545                 550                 555                 560 


Leu Gly Leu Phe Gly Ile Lys Ala Asp Ile Lys Val Glu Glu Val Gly 
                565                 570                 575     


Asp Lys His Lys Ile Ile Phe Asp Ala Gly Arg Leu Asp Val Asp Lys 
            580                 585                 590         


Gln Phe Ile Glu Thr Trp Glu Asp Val Glu Val Thr Tyr Asn Leu Thr 
        595                 600                 605             


Thr Glu Lys Gly Asn Leu Leu Ala Asn Gly Leu Phe Val Lys Asn Ser 
    610                 615                 620                 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
625                 630                 635                 640 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
                645                 650                 655     


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
            660                 665                 670         


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680                 685         


<210>  380
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_Moaa

<400>  380

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Pro Pro Thr Glu Glu Ala Val Phe Lys Phe Gly Asp 
    290                 295                 300                 


Lys Val Lys Ile Ala Thr Phe Glu Glu Val Ala Lys Asn Phe Lys Phe 
305                 310                 315                 320 


Glu His Lys Val Glu Ile Asp Gly Phe Lys Gly Glu Tyr Ser Ile Pro 
                325                 330                 335     


Asn Asp Leu Tyr Val Leu Thr Phe Asn Asp Gly Lys Ala Glu Trp Thr 
            340                 345                 350         


Arg Val Thr Lys Phe Leu Arg Arg Lys His Glu Gly Lys Ile Arg Val 
        355                 360                 365             


Ile Lys Thr Lys Thr Gly Arg Thr Ile Arg Thr Thr Pro Glu His Lys 
    370                 375                 380                 


Phe Phe Val Tyr Lys Asp Gly Glu Leu Val Lys Lys Arg Ala Asp Glu 
385                 390                 395                 400 


Leu Glu Pro Gly Asp Glu Leu Val Leu Leu Trp Arg Phe Glu Ser Glu 
                405                 410                 415     


Glu Thr Leu Thr Glu Ile Asn Leu Leu Glu Ala Phe Lys Asp Leu Pro 
            420                 425                 430         


Gln Glu Glu Lys Glu Lys Val Tyr Val Arg Gly Ile Lys Asp Leu Asp 
        435                 440                 445             


Leu Thr Pro Leu Lys Glu Lys Tyr Gly Asp Lys Val Tyr Tyr Trp Ala 
    450                 455                 460                 


Arg Gln Asp Ser Met Pro Leu Ser Val Phe Tyr Glu Leu Asn Val Asp 
465                 470                 475                 480 


Leu Asp Lys Glu Phe Arg Leu Gly Arg Asp Ala Thr Thr Tyr Glu Leu 
                485                 490                 495     


Pro Ser Lys Leu Lys Ile Thr Pro Ser Leu Ala Lys Leu Ile Gly Tyr 
            500                 505                 510         


Phe Val Ser Asp Gly Asn Tyr Ser Asp Lys Asp Leu Arg Ile Thr Val 
        515                 520                 525             


Gly His Glu Asp Val Glu Lys Glu Ile Val Asn Ile Leu Glu Glu Leu 
    530                 535                 540                 


Gly Leu Pro Tyr Ser Phe Leu Glu Trp Glu Gly Lys Thr Lys Gln Ile 
545                 550                 555                 560 


Val Ile Gly Ser Arg Leu Leu Arg Leu Val Phe Lys His Val Phe Lys 
                565                 570                 575     


Ile Pro Glu Gly Ala Pro Asn Lys Arg Leu Pro Glu Gly Phe Leu Ser 
            580                 585                 590         


Phe Pro Phe Glu Ala Lys Val Ala Leu Leu Ser Gly Leu Phe Asn Gly 
        595                 600                 605             


Asp Gly Tyr Val Val Arg Gly Glu His His Leu Ser Ile Gly Tyr Ala 
    610                 615                 620                 


Ser Thr Ser Lys Gly Leu Ile Arg Asp Ile Leu Tyr Leu Leu Ala Ser 
625                 630                 635                 640 


Leu Gly Ile Phe Ala Arg Val Tyr Arg Val Pro Lys Glu Lys Met Lys 
                645                 650                 655     


Gly Ala Asn His Asp Leu Tyr Lys Leu Tyr Ile Ala Gly Thr Asp Leu 
            660                 665                 670         


Val Arg Leu Val Glu Leu Leu Glu Leu Arg Glu Gly His Arg Glu Lys 
        675                 680                 685             


Leu Gly Glu Ile Gly Asn Arg Lys Pro Ala Arg Val Lys Lys Ile Ala 
    690                 695                 700                 


Asp Phe Tyr Ile Asp Val Val Asp Glu Val Ser Glu Glu Glu Tyr Ser 
705                 710                 715                 720 


Gly Tyr Val Tyr Asp Leu Glu Val Glu Asn Glu Gly His Ser Phe Val 
                725                 730                 735     


Ala Ala Asp Gly Ile Leu Val Ser Asn Ser Thr Tyr Ala Ser Leu Asn 
            740                 745                 750         


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
        755                 760                 765             


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
    770                 775                 780                 


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
785                 790                 795                 800 


Leu Val Asn Ala Glu Ala Ala Thr Arg 
                805                 


<210>  381
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_Pol-II

<400>  381

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Pro Gly Asp Thr Arg Ile Leu Val Gln Ile Asp Gly 
    290                 295                 300                 


Val Pro Gln Lys Ile Thr Leu Arg Glu Leu Tyr Glu Leu Phe Glu Asp 
305                 310                 315                 320 


Glu Arg Tyr Glu Asn Met Val Tyr Val Arg Lys Lys Pro Lys Arg Glu 
                325                 330                 335     


Ile Lys Val Tyr Ser Ile Asp Leu Glu Thr Gly Lys Val Val Leu Thr 
            340                 345                 350         


Asp Ile Glu Asp Val Ile Lys Ala Pro Ala Thr Asp His Leu Ile Arg 
        355                 360                 365             


Phe Glu Leu Glu Asp Gly Arg Ser Phe Glu Thr Thr Val Asp His Pro 
    370                 375                 380                 


Val Leu Val Tyr Glu Asn Gly Arg Phe Ile Glu Lys Arg Ala Phe Glu 
385                 390                 395                 400 


Val Lys Glu Gly Asp Lys Val Leu Val Ser Glu Leu Glu Leu Val Glu 
                405                 410                 415     


Gln Ser Ser Ser Ser Gln Asp Asn Pro Lys Asn Glu Asn Leu Gly Ser 
            420                 425                 430         


Pro Glu His Asp Gln Leu Leu Glu Ile Lys Asn Ile Lys Tyr Val Arg 
        435                 440                 445             


Ala Asn Asp Asp Phe Val Phe Ser Leu Asn Ala Lys Lys Tyr His Asn 
    450                 455                 460                 


Val Ile Ile Asn Glu Asn Ile Val Thr His Gln Ser Thr Tyr Ala Ser 
465                 470                 475                 480 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
                485                 490                 495     


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
            500                 505                 510         


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
        515                 520                 525             


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    530                 535                 


<210>  382
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_RFC-1

<400>  382

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Gly Asp Ala Lys Val Ile Ala Asn Gly Glu Leu 
    290                 295                 300                 


Thr Thr Ile Gly Glu Leu Val Glu Arg Ile Ser Asn Gly Lys Leu Gly 
305                 310                 315                 320 


Pro Thr Pro Val Arg Gly Leu Thr Val Leu Gly Ile Asp Glu Asp Gly 
                325                 330                 335     


Lys Leu Val Glu Leu Pro Val Glu Tyr Val Tyr Lys Asp Lys Thr Ser 
            340                 345                 350         


Glu Leu Val Lys Ile Arg Thr Arg Leu Gly Arg Glu Leu Lys Val Thr 
        355                 360                 365             


Pro Tyr His Pro Leu Leu Val Asn Arg Arg Asn Gly Lys Ile Glu Trp 
    370                 375                 380                 


Val Lys Ala Glu Glu Leu Lys Pro Gly Asp Arg Leu Ala Ile Pro Ser 
385                 390                 395                 400 


Phe Leu Pro Ala Met Leu Asn Asp Asn Pro Leu Ala Glu Trp Leu Gly 
                405                 410                 415     


Tyr Phe Phe Gly Asn Gly Tyr Thr Asp Ser Glu Glu Arg Val Val Phe 
            420                 425                 430         


Glu Ser Lys Ser Lys Glu Leu Arg Lys Arg Phe Met Glu Leu Thr Arg 
        435                 440                 445             


Lys Leu Phe Gln Asp Ala Glu Ile Lys Glu Asp Ser Gly Lys Val Tyr 
    450                 455                 460                 


Val Ser Ser Ser Glu Val Lys Arg Leu Val Lys Ser Leu Asn Lys Asp 
465                 470                 475                 480 


Ser Ile Pro Glu Gln Ala Trp Lys Gly Leu Arg Ser Phe Leu Arg Ala 
                485                 490                 495     


Tyr Phe Asp Cys Asn Ala Glu Ile Lys Asp Lys Ile Ile Val Ser Thr 
            500                 505                 510         


Ala Gly Lys Glu Ile Ala Glu Gln Ile Ser Tyr Ala Leu Ala Gly Leu 
        515                 520                 525             


Gly Ile Val Ala Glu Val Asp Asp Lys Gly Ser Val Ile Ile Ser Asp 
    530                 535                 540                 


Pro Glu Asn Val Ser Arg Phe Leu Asp Glu Ile Gly Phe Ser Val Glu 
545                 550                 555                 560 


Glu Lys Lys Glu Glu Ala Lys Ala Leu Ile Lys Lys Ser Thr Leu Asn 
                565                 570                 575     


Leu Gly Ile Tyr Val Asp Lys Glu Leu Ile Ser Tyr Val Arg Glu Lys 
            580                 585                 590         


Leu Lys Leu Ser Phe Tyr Glu Asn Glu Thr Met Trp Ser Pro Glu Lys 
        595                 600                 605             


Ala Arg Glu Ile Ala Trp Lys Leu Met Lys Glu Ile Tyr Tyr Arg Leu 
    610                 615                 620                 


Asp Glu Leu Glu Arg Phe Lys Lys Ala Leu Ser Lys Ser Val Ile Ile 
625                 630                 635                 640 


Asp Trp Ser Glu Val Glu Lys Lys Lys Glu Glu Ile Ser Glu Lys Thr 
                645                 650                 655     


Gly Ile Ser Val Asn Glu Ile Leu Glu Tyr Ala Lys Gly Lys Arg Lys 
            660                 665                 670         


Pro Ser Leu Glu Glu Tyr Val Lys Ile Ala Lys Ala Leu Gly Val Glu 
        675                 680                 685             


Leu Lys Glu Thr Leu Glu Ala Ile Phe Thr Phe Gly Lys Lys Tyr Leu 
    690                 695                 700                 


Gly Tyr Val Ile Ser Asp Glu Ile Glu Thr Leu Glu Glu Val Arg Lys 
705                 710                 715                 720 


Glu Glu Leu Lys Arg Leu Lys Glu Leu Leu Asn Asp Glu Lys Leu Lys 
                725                 730                 735     


Lys Gly Val Ala Tyr Leu Ile Phe Leu Ala Gln Asn Glu Leu Leu Trp 
            740                 745                 750         


Asp Glu Ile Ile Glu Val Glu Lys Leu Lys Gly Asp Phe Val Ile Tyr 
        755                 760                 765             


Asp Leu His Val Pro Lys Tyr His Asn Phe Ile Gly Gly Asn Leu Pro 
    770                 775                 780                 


Thr Val Leu His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
785                 790                 795                 800 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                805                 810                 815     


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            820                 825                 830         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        835                 840                 845             


Glu Ala Ala Thr Arg 
    850             


<210>  383
<211>  962
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_RFC-2

<400>  383

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Gly Asp Thr Lys Val Tyr Thr Pro Asp Glu Arg 
    290                 295                 300                 


Glu Val Lys Ile Arg Asp Phe Met Asn Tyr Phe Glu Asn Gly Leu Ile 
305                 310                 315                 320 


Lys Glu Val Ser Asn Arg Ile Gly Arg Asp Thr Val Ile Ala Ala Val 
                325                 330                 335     


Ser Phe Asn Ser Arg Ile Val Gly His Pro Val Tyr Arg Leu Thr Leu 
            340                 345                 350         


Glu Ser Gly Arg Ile Ile Glu Ala Thr Gly Asp His Met Phe Leu Thr 
        355                 360                 365             


Pro Glu Gly Trp Lys Gln Thr Tyr Asp Ile Lys Glu Gly Ser Glu Val 
    370                 375                 380                 


Leu Val Lys Pro Thr Leu Glu Gly Thr Pro Tyr Glu Pro Asp Pro Arg 
385                 390                 395                 400 


Val Ile Ile Asp Ile Lys Glu Phe Tyr Asn Phe Leu Glu Lys Ile Glu 
                405                 410                 415     


Arg Glu His Asn Leu Lys Pro Leu Lys Glu Ala Lys Thr Phe Arg Glu 
            420                 425                 430         


Leu Ile Thr Lys Asp Lys Glu Lys Ile Leu Arg Arg Ala Leu Glu Leu 
        435                 440                 445             


Arg Ala Glu Ile Glu Asn Gly Leu Thr Lys Arg Glu Ala Glu Ile Leu 
    450                 455                 460                 


Glu Leu Ile Ser Ala Asp Thr Trp Ile Pro Arg Ala Glu Leu Glu Lys 
465                 470                 475                 480 


Lys Ala Arg Ile Ser Arg Thr Arg Leu Asn Gln Ile Leu Gln Arg Leu 
                485                 490                 495     


Glu Lys Lys Gly Tyr Ile Glu Arg Arg Ile Glu Gly Arg Lys Gln Phe 
            500                 505                 510         


Val Arg Lys Ile Arg Asn Gly Lys Ile Leu Arg Asn Ala Met Asp Ile 
        515                 520                 525             


Lys Arg Ile Leu Glu Glu Glu Phe Gly Ile Lys Ile Ser Tyr Thr Thr 
    530                 535                 540                 


Val Lys Lys Leu Leu Ser Gly Asn Val Asp Gly Met Ala Tyr Arg Ile 
545                 550                 555                 560 


Leu Lys Glu Val Lys Glu Lys Trp Leu Val Arg Tyr Asp Asp Glu Lys 
                565                 570                 575     


Ala Gly Ile Leu Ala Arg Val Val Gly Phe Ile Leu Gly Asp Gly His 
            580                 585                 590         


Leu Ala Arg Asn Gly Arg Ile Trp Phe Asn Ser Ser Lys Glu Glu Leu 
        595                 600                 605             


Glu Met Leu Ala Asn Asp Leu Arg Lys Leu Gly Leu Lys Pro Ser Glu 
    610                 615                 620                 


Ile Ile Glu Arg Asp Ser Ser Ser Glu Ile Gln Gly Arg Lys Val Lys 
625                 630                 635                 640 


Gly Arg Ile Tyr Met Leu Tyr Val Asp Asn Ala Ala Phe His Ala Leu 
                645                 650                 655     


Leu Arg Phe Trp Lys Val Glu Val Gly Asn Lys Thr Lys Lys Gly Tyr 
            660                 665                 670         


Thr Val Pro Glu Trp Ile Lys Lys Gly Asn Leu Phe Val Lys Arg Glu 
        675                 680                 685             


Phe Leu Arg Gly Leu Phe Gly Ala Asp Gly Thr Lys Pro Cys Gly Lys 
    690                 695                 700                 


Arg Tyr Asn Phe Asn Gly Ile Lys Leu Glu Ile Arg Ala Lys Lys Glu 
705                 710                 715                 720 


Ser Leu Glu Arg Thr Val Glu Phe Leu Asn Asp Val Ala Asp Leu Leu 
                725                 730                 735     


Arg Glu Phe Asp Val Asp Ser Lys Ile Thr Val Ser Pro Thr Lys Glu 
            740                 745                 750         


Gly Phe Ile Ile Arg Leu Ile Val Thr Pro Asn Asp Ala Asn Tyr Leu 
        755                 760                 765             


Asn Phe Leu Thr Arg Val Gly Tyr Ala Tyr Ala Lys Asp Thr Tyr Ala 
    770                 775                 780                 


Arg Leu Val Gly Glu Tyr Ile Arg Ile Lys Leu Ala Tyr Lys Asn Ile 
785                 790                 795                 800 


Ile Leu Pro Gly Ile Ala Glu Lys Ala Ile Glu Leu Ala Thr Val Thr 
                805                 810                 815     


Asn Ser Thr Tyr Ala Ala Lys Val Leu Gly Val Ser Arg Asp Phe Val 
            820                 825                 830         


Val Asn Arg Leu Lys Gly Thr Gln Ile Gly Ile Thr Arg Asp Phe Met 
        835                 840                 845             


Thr Phe Glu Glu Phe Met Lys Glu Arg Val Leu Asn Gly Tyr Val Ile 
    850                 855                 860                 


Glu Lys Val Ile Lys Lys Glu Lys Leu Gly Tyr Leu Asp Val Tyr Asp 
865                 870                 875                 880 


Val Thr Cys Ala Arg Asp His Ser Phe Ile Ser Asn Gly Leu Val Ser 
                885                 890                 895     


His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
            900                 905                 910         


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
        915                 920                 925             


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
    930                 935                 940                 


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
945                 950                 955                 960 


Thr Arg 
        


<210>  384
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_RIR1-1

<400>  384

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Ile Asp Gly Asn Ala Lys Ile Ile Phe Glu Asn Glu Gly 
    290                 295                 300                 


Glu Glu His Leu Thr Thr Met Ala Glu Met Tyr Glu Arg Tyr Arg His 
305                 310                 315                 320 


Leu Gly Glu Phe Tyr Asp Glu Asn Tyr Asn Arg Trp Gly Ile Asp Val 
                325                 330                 335     


Ser Ser Val Pro Ile Tyr Val Lys Ser Phe Asp Pro Glu Thr Arg Arg 
            340                 345                 350         


Val Val Lys Gly Arg Val Arg Ala Ile Trp Lys Tyr Glu Leu Gly Glu 
        355                 360                 365             


Glu Ile Pro Lys Tyr Glu Ile Arg Thr His Lys Gly Thr Lys Ile Leu 
    370                 375                 380                 


Thr Ser Pro Trp His Pro Phe Phe Val Leu Thr Pro Asp Phe Glu Val 
385                 390                 395                 400 


Ile Glu Lys Arg Ala Asp Glu Leu Lys Val Gly Asp Ile Leu Ile Gly 
                405                 410                 415     


Gly Met Pro Asp Gly Glu Asp His Glu Leu Ile Phe Asp Tyr Trp Leu 
            420                 425                 430         


Ala Gly Phe Ile Ala Gly Asn Gly Asn Leu Asp Asp Ser Glu Arg Glu 
        435                 440                 445             


Tyr Lys Ala Arg Glu Leu Leu Asp Gly Ile Glu Asn Gly Ile Pro Pro 
    450                 455                 460                 


Lys Ile Leu Arg Lys Gly Lys Asn Ala Val Leu Ser Phe Ile Thr Gly 
465                 470                 475                 480 


Leu Phe Asp Ala Glu Gly His Val Asn Asp Lys Ser Gly Ile Glu Leu 
                485                 490                 495     


Gly Met Val Asn Lys Lys Leu Ile Glu Ala Val Thr His Tyr Leu Asn 
            500                 505                 510         


Ser Leu Gly Ile Lys Ala Arg Met Arg Glu Lys Arg Arg Lys Asn Gly 
        515                 520                 525             


Ile Asp Tyr Ile Met His Val Glu Glu Tyr Ser Ser Leu Leu Arg Phe 
    530                 535                 540                 


Tyr Glu Leu Ile Gly Lys His Leu Gln Asn Asn Glu Lys Lys Glu Lys 
545                 550                 555                 560 


Leu Glu Ile Leu Leu His Lys His Asn Gly Gly Ala Phe Asp Leu Ser 
                565                 570                 575     


Leu Asn Phe Asn Ala Phe Lys Glu Trp Ala Ser Arg Tyr Gly Val Glu 
            580                 585                 590         


Phe Lys Thr Asn Gly Asn Gln Ile Leu Ala Ile Ile Gly Asn Glu Lys 
        595                 600                 605             


Val Ser Leu Gly Gln Trp His Ala Arg Gly His Val Ser Lys Ala Val 
    610                 615                 620                 


Leu Val Lys Met Leu Arg Lys Leu Tyr Glu Val Thr Lys Asn Asp Glu 
625                 630                 635                 640 


Val Lys Glu Met Leu His Leu Ile Glu Ser Leu Glu Val Val Lys Glu 
                645                 650                 655     


Ile Thr Ile Thr Asn Glu Pro Lys Thr Phe Tyr Asp Leu Thr Val Asp 
            660                 665                 670         


Lys Tyr Gln Asn Tyr Leu Ala Gly Glu Asn Gly Met Ile Phe Val His 
        675                 680                 685             


Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
    690                 695                 700                 


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
705                 710                 715                 720 


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
                725                 730                 735     


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
            740                 745                 750         


Arg 
    


<210>  385
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_RIR1-2

<400>  385

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Thr Gly Asp Thr Arg Ile Leu Thr Glu Lys Gly Leu 
    290                 295                 300                 


Ile Pro Ile Glu Glu Ile Val His Glu Thr Gly Lys Lys Pro Lys Val 
305                 310                 315                 320 


Val Thr His Ala Gly Leu Lys Asp Ile Ile Glu Thr Tyr Asp Asn Gly 
                325                 330                 335     


Glu Met Glu Val Phe Arg Val Thr Thr Glu Asp Gly Tyr Glu Leu Lys 
            340                 345                 350         


Val Thr Gly Asp His Lys Phe Leu Val Phe Asp Glu Asn Gly Asn Pro 
        355                 360                 365             


Thr Leu Lys Pro Leu Lys Glu Leu Lys Val Gly Asp Tyr Val Tyr Ile 
    370                 375                 380                 


Leu Ala Pro Glu Trp Lys Gly Gly Glu Tyr Val Glu Leu Asp Thr Asn 
385                 390                 395                 400 


Ile Glu Leu Lys Gly Lys Gly Tyr Asn Val Asn Leu Pro Ser Lys Leu 
                405                 410                 415     


Asp Glu Lys Leu Ala Tyr Leu Leu Gly Ile Ile Tyr Ala Asp Gly His 
            420                 425                 430         


Ile Arg His Tyr Phe Glu Asn Gly Lys Arg Lys Asn Ser Lys Ile Glu 
        435                 440                 445             


Ile Tyr Leu His Gln Asp Glu Thr Glu Ile Lys Glu Lys Val Lys Arg 
    450                 455                 460                 


Tyr Phe Lys Glu Ile Phe Gly Ile Glu Pro Lys Glu Phe Leu Lys Glu 
465                 470                 475                 480 


Glu Gln His Lys Val Ile Leu Val Ile Pro Ser Thr Lys Ile Val Lys 
                485                 490                 495     


Phe Leu Glu Ile Asn Gly Leu Leu Lys Asp Lys Ser Glu Asn Ile Arg 
            500                 505                 510         


Val Pro Glu Ala Ile Phe Arg Ser Arg Pro Ser Val Ile Ala Ala Phe 
        515                 520                 525             


Leu Ala Gly Phe Phe Asp Gly Asp Gly Ser Ile Asp Gln Asn Tyr Arg 
    530                 535                 540                 


Ile Ala Phe Lys Ser Ile Ser Arg Glu Phe Ile Lys Glu Ala Gln Leu 
545                 550                 555                 560 


Leu Phe Leu Ala Leu Gly Ile Val Thr Ser Ile Gln Glu Tyr Asn Pro 
                565                 570                 575     


Pro Asn Pro Asn Asn Lys Thr Val Tyr Thr Leu Arg Val Gln Thr Arg 
            580                 585                 590         


Asp Met Lys Ile Lys Ala Phe Asn Val Leu Lys Glu Ser Val Lys Leu 
        595                 600                 605             


Ser Lys Ile Met Lys Glu Ala Ile Ser Lys Leu Glu Glu Asn Gly Lys 
    610                 615                 620                 


Asn Lys Lys Phe Ser Phe Pro Phe Asn Ala Ile Tyr His Ile Lys Asp 
625                 630                 635                 640 


Pro Lys Ile Arg Ala Lys Ile Gln Arg Asp Tyr Lys Ile Leu Ser Tyr 
                645                 650                 655     


Asn Ser Lys Val Thr His Arg Ala Phe Ile Asn Asn Ile Leu Lys Leu 
            660                 665                 670         


Lys Glu Glu Leu Gly Leu Asp Asp Glu Glu Val Lys Tyr Phe Glu Met 
        675                 680                 685             


Leu Ser Lys Leu Tyr Pro Thr Lys Ile Thr Lys Ile Glu Pro Leu Gly 
    690                 695                 700                 


Lys Ala His Val Tyr Asp Leu Gln Val Glu Asp Val His Leu Leu Thr 
705                 710                 715                 720 


Gly Asn Gly Ile Tyr Thr Ser Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
                725                 730                 735     


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            740                 745                 750         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        755                 760                 765             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    770                 775                 780                 


Val Asn Ala Glu Ala Ala Thr Arg 
785                 790         


<210>  386
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_RIR1-3

<400>  386

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Val Gly Glu Thr Arg Ile Leu Thr Pro Glu Gly Tyr 
    290                 295                 300                 


Ile Lys Ala Glu Glu Leu Phe Lys Leu Ala Lys Glu Arg Gly Lys Met 
305                 310                 315                 320 


Glu Ala Ile Ala Val Glu Gly Ile Ala Glu Gly Gly Glu Pro Tyr Ala 
                325                 330                 335     


Tyr Ser Leu Glu Ile Leu Leu Pro Gly Asp Lys Gln Val Lys Tyr Glu 
            340                 345                 350         


Thr Val His Gly Asn Ala Val Glu Val Ala Asp Pro Val Ser Val Pro 
        355                 360                 365             


Ala Tyr Val Trp Lys Val Gly Met Lys Glu Val Ala Arg Val Arg Thr 
    370                 375                 380                 


Lys Glu Gly Tyr Glu Ile Thr Ala Thr Leu Asp His Lys Leu Met Thr 
385                 390                 395                 400 


Pro Glu Gly Trp Lys Glu Ile Lys Asp Leu Lys Pro Gly Asp Lys Ile 
                405                 410                 415     


Leu Leu Pro Arg Phe Glu Val Glu Glu Asp Phe Gly Ser Glu Ser Ile 
            420                 425                 430         


Gly Glu Asp Leu Ala Phe Val Leu Gly Trp Phe Ile Gly Asp Gly Tyr 
        435                 440                 445             


Leu Asn Val Lys Asp Lys Arg Ala Trp Phe Tyr Phe Asn Ala Glu Lys 
    450                 455                 460                 


Glu Glu Glu Ile Ala Trp Lys Ile Arg Glu Ile Leu Ala Lys Arg Phe 
465                 470                 475                 480 


Glu Ile Lys Ala Glu Pro His Arg Tyr Gly Asn Gln Ile Lys Leu Gly 
                485                 490                 495     


Val Arg Gly Lys Ala Tyr Glu Trp Leu Glu Ser Ile Val Lys Thr Asn 
            500                 505                 510         


Glu Lys Arg Ile Pro Glu Ile Val Tyr Arg Leu Lys Pro Asn Glu Ile 
        515                 520                 525             


Ala Ser Phe Leu Arg Gly Leu Phe Ser Ala Asp Gly Tyr Val Asp Asn 
    530                 535                 540                 


Asp Met Ala Ile Arg Leu Thr Ser Lys Ser Arg Glu Leu Leu Arg Glu 
545                 550                 555                 560 


Val Gln Asp Leu Leu Leu Leu Phe Gly Ile Leu Ser Lys Ile Tyr Glu 
                565                 570                 575     


Arg Pro Tyr Lys Arg Glu Phe Lys Tyr Thr Thr Lys Asp Gly Glu Glu 
            580                 585                 590         


Arg Thr Tyr Thr Thr Glu Gly Tyr Tyr Glu Leu Val Ile Ala Asn Tyr 
        595                 600                 605             


Ser Arg Lys Ile Phe Ala Glu Arg Ile Gly Leu Glu Gly Tyr Lys Met 
    610                 615                 620                 


Glu Lys Leu Ser Leu Glu Lys Ile Lys Val Asp Glu Pro Ile Val Thr 
625                 630                 635                 640 


Val Glu Ser Val Glu Ile Leu Gly Lys Lys Leu Val Tyr Asp Phe Thr 
                645                 650                 655     


Val Pro Glu His His Met Tyr Ile Ser Asn Gly Phe Met Ser His Asn 
            660                 665                 670         


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
        675                 680                 685             


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
    690                 695                 700                 


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
705                 710                 715                 720 


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730                 735     


<210>  387
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Pab_RtcB_Pab_Hyp-2

<400>  387

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ala Pro Gly Ser Lys Val Leu Thr Glu His Gly Tyr 
    290                 295                 300                 


Trp Leu Lys Val Glu Glu Leu Pro Glu Lys Phe Lys Leu Gln Gly Val 
305                 310                 315                 320 


Lys Val Tyr Asn Leu Asp Glu Gly His Asn Asp Thr Ser Asn Val Ala 
                325                 330                 335     


Phe Val Ala Glu Arg Glu Val Glu Thr Gly Glu Met Ala Val Arg Val 
            340                 345                 350         


Thr Thr Glu Ser Gly Arg Ile Ile Glu Gly Ser Glu Asp His Pro Val 
        355                 360                 365             


Leu Thr Pro Glu Gly Tyr Val Tyr Leu Gly Asn Leu Lys Glu Gly Asn 
    370                 375                 380                 


Leu Val Ile Val Tyr Pro Phe Glu Gly Val Glu Tyr Glu Glu Arg Lys 
385                 390                 395                 400 


Gly Val Ile Leu Asp Glu Asp Ala Phe Lys Asp Glu Asp Pro Gln Val 
                405                 410                 415     


Leu Ser Phe Leu Arg Glu Lys Gly Leu Val Pro Leu Arg Trp Asp Asp 
            420                 425                 430         


Pro Arg Ile Gly Thr Ile Ala Arg Ile Leu Gly Phe Ala Phe Gly Asp 
        435                 440                 445             


Gly Tyr Leu Gly Glu Met Gly Gly Arg Leu Thr Leu Thr Phe Tyr Gly 
    450                 455                 460                 


Lys Glu Glu Thr Leu Arg Glu Leu Lys Lys Asp Leu Glu Arg Leu Gly 
465                 470                 475                 480 


Ile Ser Ala Asn Leu Tyr Val Arg Glu Ser Ile Glu Thr Thr Ser Gly 
                485                 490                 495     


His Ser Glu Gly Lys Ser Leu Ser Ile Glu Leu Arg Val Thr Ser Arg 
            500                 505                 510         


Ser Phe Ala Leu Phe Leu Glu Lys Leu Gly Met Pro Arg Gly Lys Lys 
        515                 520                 525             


Thr Glu Lys Ala Tyr Arg Val Pro Gly Trp Ile Leu Glu Ala Pro Leu 
    530                 535                 540                 


Trp Val Lys Arg Asn Phe Leu Ala Gly Leu Phe Ala Ala Asp Gly Ser 
545                 550                 555                 560 


Ile Val Glu Phe Lys Gly Asn Thr Pro Leu Pro Ile Asn Leu Thr Gln 
                565                 570                 575     


Ser Lys Ser Asp Glu Leu Ala Glu Asn Leu Val Glu Phe Leu Gly Asp 
            580                 585                 590         


Val Ala Lys Leu Leu Ala Glu Phe Gly Ile Glu Thr Thr Leu Tyr Glu 
        595                 600                 605             


Val Lys Ser Lys Lys Gly Val Thr Tyr Arg Leu Ser Ile Val Gly Glu 
    610                 615                 620                 


Asp Ser Ile Arg Thr Phe Val Glu Arg Ile Asn Tyr Glu Tyr Asp Pro 
625                 630                 635                 640 


Glu Lys Lys Val Lys Gly Leu Ile Ala Ala Ala Tyr Leu Lys Leu Lys 
                645                 650                 655     


Glu Arg Ile Val Lys Glu Ala His Glu Ala Val Lys Asp Asp Phe Pro 
            660                 665                 670         


Thr Phe Glu Glu Phe Ala Lys Glu Arg Gly Tyr Glu Gly Gly Phe Val 
        675                 680                 685             


Ala Glu Lys Val Val Lys Val Glu Arg Val Lys Pro Glu Tyr Thr Lys 
    690                 695                 700                 


Phe Tyr Asp Ile Gly Val Tyr His Glu Ala His Asn Phe Ile Ala Asn 
705                 710                 715                 720 


Gly Ile Val Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
                725                 730                 735     


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
            740                 745                 750         


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
        755                 760                 765             


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
    770                 775                 780                 


Ala Glu Ala Ala Thr Arg 
785                 790 


<210>  388
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_VMA

<400>  388

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Asp Gly Asp Thr Leu Val Leu Thr Lys Glu Phe Gly 
    290                 295                 300                 


Leu Ile Lys Ile Lys Asp Leu Tyr Lys Ile Leu Asp Gly Lys Gly Lys 
305                 310                 315                 320 


Lys Thr Val Asn Gly Asn Glu Glu Trp Thr Glu Leu Glu Arg Pro Ile 
                325                 330                 335     


Thr Leu Tyr Gly Tyr Lys Asp Gly Lys Ile Val Glu Ile Lys Ala Thr 
            340                 345                 350         


His Val Tyr Lys Gly Phe Ser Ala Gly Met Ile Glu Ile Arg Thr Arg 
        355                 360                 365             


Thr Gly Arg Lys Ile Lys Val Thr Pro Ile His Lys Leu Phe Thr Gly 
    370                 375                 380                 


Arg Val Thr Lys Asn Gly Leu Glu Ile Arg Glu Val Met Ala Lys Asp 
385                 390                 395                 400 


Leu Lys Lys Gly Asp Arg Ile Ile Val Ala Lys Lys Ile Asp Gly Gly 
                405                 410                 415     


Glu Arg Val Lys Leu Asn Ile Arg Val Glu Gln Lys Arg Gly Lys Lys 
            420                 425                 430         


Ile Arg Ile Pro Asp Val Leu Asp Glu Lys Leu Ala Glu Phe Leu Gly 
        435                 440                 445             


Tyr Leu Ile Ala Asp Gly Thr Leu Lys Pro Arg Thr Val Ala Ile Tyr 
    450                 455                 460                 


Asn Asn Asp Glu Ser Leu Leu Arg Arg Ala Asn Glu Leu Ala Asn Glu 
465                 470                 475                 480 


Leu Phe Asn Ile Glu Gly Lys Ile Val Lys Gly Arg Thr Val Lys Ala 
                485                 490                 495     


Leu Leu Ile His Ser Lys Ala Leu Val Glu Phe Phe Ser Lys Leu Gly 
            500                 505                 510         


Val Pro Arg Asn Lys Lys Ala Arg Thr Trp Lys Val Pro Lys Glu Leu 
        515                 520                 525             


Leu Ile Ser Glu Pro Glu Val Val Lys Ala Phe Ile Lys Ala Tyr Ile 
    530                 535                 540                 


Met Cys Asp Gly Tyr Tyr Asp Glu Asn Lys Gly Glu Ile Glu Ile Val 
545                 550                 555                 560 


Thr Ala Ser Glu Glu Ala Ala Tyr Gly Phe Ser Tyr Leu Leu Ala Lys 
                565                 570                 575     


Leu Gly Ile Tyr Ala Ile Ile Arg Glu Lys Ile Ile Gly Asp Lys Val 
            580                 585                 590         


Tyr Tyr Arg Val Val Ile Ser Gly Glu Ser Asn Leu Glu Lys Leu Gly 
        595                 600                 605             


Ile Glu Arg Val Gly Arg Gly Tyr Thr Ser Tyr Asp Ile Val Pro Val 
    610                 615                 620                 


Glu Val Glu Glu Leu Tyr Asn Ala Leu Gly Arg Pro Tyr Ala Glu Leu 
625                 630                 635                 640 


Lys Arg Ala Gly Ile Glu Ile His Asn Tyr Leu Ser Gly Glu Asn Met 
                645                 650                 655     


Ser Tyr Glu Met Phe Arg Lys Phe Ala Lys Phe Val Gly Met Glu Glu 
            660                 665                 670         


Ile Ala Glu Asn His Leu Thr His Val Leu Phe Asp Glu Ile Val Glu 
        675                 680                 685             


Ile Arg Tyr Ile Ser Glu Gly Gln Glu Val Tyr Asp Val Thr Thr Glu 
    690                 695                 700                 


Thr His Asn Phe Ile Gly Gly Asn Met Pro Thr Leu Leu His Asn Ser 
705                 710                 715                 720 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
                725                 730                 735     


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
            740                 745                 750         


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
        755                 760                 765             


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780             


<210>  389
<211>  1003
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pan_CHS2

<400>  389

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ser Pro Asp Thr Met Val Arg Thr Thr Asn Gly Asp 
    290                 295                 300                 


Lys Pro Ile Arg Asp Ile Ala Val Gly Asp Gln Leu Phe Asp His Glu 
305                 310                 315                 320 


Asp Arg Pro Val Gln Cys Leu Ala Ala Glu Ala Ile Gln Thr Ser Arg 
                325                 330                 335     


Met Met Lys Val Thr Tyr Thr Gly Tyr Asn Ser Val Ser Lys Ser Ser 
            340                 345                 350         


Phe Thr Cys Thr Pro Asp His Ile Met Thr Leu Val Ala Tyr Gly Val 
        355                 360                 365             


Lys Pro Phe Arg His Ser Asn Ser Asn Arg Val Thr Trp Trp Thr Arg 
    370                 375                 380                 


Cys Asp Arg Thr Glu Leu Gly Ala Asp Ala Val Glu Ile Lys Trp Asp 
385                 390                 395                 400 


Ala Ala Met His Asp Leu Tyr Thr Glu Tyr Arg Glu Gln Leu Gly Arg 
                405                 410                 415     


Arg Pro Thr Asp Ala Glu Val Arg Lys Tyr Leu Lys Ala Ile Thr Ser 
            420                 425                 430         


Thr Arg Val Val Pro Asp Ser Glu Asp Asp Asp Ser Gln Arg Val Glu 
        435                 440                 445             


Glu Thr Tyr Gln Ser Pro Val Leu Ile Lys Leu Leu Ala Lys Leu Lys 
    450                 455                 460                 


Ala Met Asp Val Asp Val Asp Gly Glu Asp Glu Ser Val Val Leu Met 
465                 470                 475                 480 


Leu Leu Gln Gln His Met Glu Asp Tyr Leu Glu His Met Ile Pro Glu 
                485                 490                 495     


Pro Glu Asp Ile Ser Asp Glu Asp Asn Asp Asp Leu Ile Ile Asp Leu 
            500                 505                 510         


Asp Thr Asn Arg Lys Arg Lys Ile Gly Thr Ile Ser Thr Leu Ser Ser 
        515                 520                 525             


Arg Ile Ser Asp Lys Thr Phe Arg Gln Ser Pro Ser Ile Lys Ser Ser 
    530                 535                 540                 


Pro Val Asn Ser Gln Gln Gln Ser Gln Asn Glu Ala Ser Gln Ser Thr 
545                 550                 555                 560 


Val Pro Thr Tyr Ala Ser Val Leu Thr Glu Asp Asp His Arg Glu Met 
                565                 570                 575     


Phe Ala Pro Val Arg Ser Lys Leu Ala Val Arg Asp Pro Lys Cys Lys 
            580                 585                 590         


Cys Gln Asn Leu Ser Cys Lys Gly Leu Arg Arg Val Ser Thr Val Phe 
        595                 600                 605             


Glu Thr Ser Glu Gln Ala Asp Leu Ala Leu Glu Leu Leu Ser Gly Asp 
    610                 615                 620                 


His Tyr Arg Val Val Asp Pro Cys Ala Val Gln Asp Met Glu Val Phe 
625                 630                 635                 640 


Thr Met Thr Leu Glu Glu Tyr Gln Ala Thr Cys Thr Ala Pro Met Thr 
                645                 650                 655     


Gln His Lys Ser Lys Leu Arg Leu Tyr Arg Ser Pro Leu Arg Phe Gln 
            660                 665                 670         


Pro Tyr Gln Gly Ser Val Ser Pro Val Pro Ile Asp Pro Phe Trp Phe 
        675                 680                 685             


Gly Phe Trp Leu Gly Asn Gly Thr Lys Asn Asn Ser Glu Ile Thr Ser 
    690                 695                 700                 


Thr Asp Pro Glu Val Glu Val Tyr Thr Gln Ala Leu Val Asp Arg Leu 
705                 710                 715                 720 


Asn Arg Asp Ser Ile Pro Pro Gly Lys Ala Pro Leu Lys Val Ser Lys 
                725                 730                 735     


Tyr Lys Ile Asp Ile Gly Thr Lys His Val Tyr Lys Gly Glu Glu Ile 
            740                 745                 750         


Lys Thr Thr Lys Val Ala His Arg Leu Arg Val Met Ser Thr Val Ser 
        755                 760                 765             


Asn Leu Asp Lys Thr His Trp Asn Pro Val His Asp Gly Leu Arg Glu 
    770                 775                 780                 


Leu Gly Leu Leu Gly Asp Lys Ser Gly Gly Ile Pro Asp Cys Tyr Met 
785                 790                 795                 800 


Asn Ala Asp Glu Asn Thr Arg Leu Ala Val Leu Ala Gly Leu Ile Glu 
                805                 810                 815     


Ser Asp Gly Trp Leu Ser His Gly Leu Asn Cys Tyr Gly Phe Gly Gln 
            820                 825                 830         


Tyr Thr Tyr Glu Leu Lys Lys Leu Val Glu Asp Ala Arg Lys Leu Ala 
        835                 840                 845             


Leu Ser Cys Gly Ile Gln Cys Asn Pro Ile Phe Glu Arg Lys Asn Gly 
    850                 855                 860                 


Lys Asp Arg Pro Glu Pro Gly Trp Phe Phe Tyr Met Gly Arg Gly Val 
865                 870                 875                 880 


Glu Lys Phe Gln Pro His Leu Leu Leu Pro Arg Lys Arg Met Thr Ile 
                885                 890                 895     


Pro Phe Thr Thr Ser Lys Asn Arg Asp Val Arg Pro Phe Asp Val Glu 
            900                 905                 910         


Asp Ala Gly Asp Gly Glu Phe Arg Leu Ile Glu Val Ser Gly Glu Leu 
        915                 920                 925             


Phe Gln Leu Ala Asp Arg Thr Val Val His Asn Ser Thr Tyr Ala Ser 
    930                 935                 940                 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
945                 950                 955                 960 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
                965                 970                 975     


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
            980                 985                 990         


Ser Gly Leu Val Asn Ala Glu Ala  Ala Thr Arg 
        995                 1000             


<210>  390
<211>  927
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pbr_PRP8

<400>  390

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ala Lys Gly Thr Leu Leu Leu Arg Tyr Asp Gly Thr 
    290                 295                 300                 


Lys Val Glu Val Glu Asn Val Arg Glu Gly Asp Leu Leu Leu Gly Pro 
305                 310                 315                 320 


Asp Gly Gly Pro Arg Arg Ala Phe Asn Ile Val Gly Gly Arg Asp Arg 
                325                 330                 335     


Leu Tyr Arg Ile Lys Met Glu Gly Gly Lys Glu Asp Leu Val Val Thr 
            340                 345                 350         


Pro Asn His Ile Leu Val Leu His Arg Glu Lys Arg Asp Gly Val Asp 
        355                 360                 365             


Lys Val Tyr Ala Arg Pro Phe Ala Leu Pro Leu Leu Gln Glu Asp Ala 
    370                 375                 380                 


Thr Asp Asp Gly Glu Asp Leu Ser Glu Ile Ser Ala Ile Glu His Phe 
385                 390                 395                 400 


Asp Thr Met Glu Ile Thr Ala Ala Asp Phe Ala Ser Leu Asp Pro Asn 
                405                 410                 415     


Glu Arg Lys Leu Tyr Arg Leu Phe Thr Ser Pro Gly Tyr Glu Leu Asn 
            420                 425                 430         


Gly Arg Pro Val Pro Ile Asp Pro Tyr Phe Leu Gly Leu Trp Leu Gly 
        435                 440                 445             


Asp Arg Ser Arg Thr Lys Ser Ser Ile Tyr Thr Asn His Glu Glu Glu 
    450                 455                 460                 


Ile Arg Glu Phe Ile Ala Asp His Ala Ala Glu Leu Asp Leu Gln Leu 
465                 470                 475                 480 


Val Ser Tyr Val Ser Asn Arg Pro Ser Leu Ala Ala Met Lys Asn Gly 
                485                 490                 495     


Asn Gln Leu Pro Leu Arg His Gln Ala Arg Gln Thr Ile Arg Lys Gln 
            500                 505                 510         


Arg Ile Ala Ala Lys Ser Ile Thr Gln Pro Gly Gly Ala Arg Ser Ser 
        515                 520                 525             


Ser Tyr Pro Ala Thr Asn Gly Gly Leu Ser Ser Asn Thr Val Thr Ser 
    530                 535                 540                 


Leu His Ser Arg Glu Arg His Pro Leu Ser Glu Ser Ser Ala Ala Ala 
545                 550                 555                 560 


Thr Met Asn Leu Leu Pro Arg Ser Thr Ser Val Ser Thr Ser Val Ala 
                565                 570                 575     


Ala Gln Pro Lys Ser Ser Met Ser Thr Phe Ile Thr Asp Ala Ile Leu 
            580                 585                 590         


Pro Ser Glu Ser Ser Asn Ile Ser Val Ile Ser Asp Ser Gly Ile Glu 
        595                 600                 605             


Ile Ser Lys Ser Ser Lys Met Leu Ser Glu Glu Glu Ala Asp Leu Asp 
    610                 615                 620                 


Leu Phe Asp Ile Asp Ser Glu Asp Glu Glu Ile Glu Asp Leu Asp Glu 
625                 630                 635                 640 


Lys Lys Asn Val Ser Asn Val Asp Glu Phe Pro Lys Arg Arg Arg Ile 
                645                 650                 655     


His Tyr Leu Arg Thr Gly Cys Arg Thr Tyr Gly Glu Leu Cys Pro Gly 
            660                 665                 670         


Glu Glu Asp Gln Ile Leu Glu Asp Ile Val Gly Arg Pro Asp Gly Thr 
        675                 680                 685             


Thr Ser Val Glu Ser Leu Leu Leu Ala Leu Glu Ala Leu Gly Leu His 
    690                 695                 700                 


Thr Cys Gly Thr Asn Asp Ser Gly Ser Asp Lys Lys Arg Ile Pro Ser 
705                 710                 715                 720 


Val Tyr Met Lys Asn Ser Arg Ala Val Arg Leu Ala Leu Leu Ala Gly 
                725                 730                 735     


Leu Ile Asp Ser Gly Gly Trp Tyr Val Asp Ser Glu Asn Thr Phe Gly 
            740                 745                 750         


Phe Ser Gln Thr Glu Asp Ser Asn Ser Thr Leu Ile Trp Asp Val Val 
        755                 760                 765             


Thr Leu Ala Arg Ser Leu Gly Phe Ser Val Ser Thr Lys Arg Arg Met 
    770                 775                 780                 


Thr His Lys Pro Thr Arg Thr Gln His Lys Ala Gln Glu Phe Ala Gln 
785                 790                 795                 800 


Ile Ser Gly Asn Val Ala Glu Ile Pro Ser Leu Leu Ala Arg Glu Arg 
                805                 810                 815     


Gly Val Glu Arg Pro Ile Ser Gln Ala His Ser Phe Lys Ile Lys Asp 
            820                 825                 830         


Ile Gln Leu Glu Thr Glu Ala Thr Glu Trp Ala Gly Phe Arg Val Asp 
        835                 840                 845             


Gln Asp Gln Leu Tyr Leu Arg His Asp Phe Leu Val Leu His Asn Ser 
    850                 855                 860                 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
865                 870                 875                 880 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
                885                 890                 895     


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
            900                 905                 910         


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        915                 920                 925         


<210>  391
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pch_PRP8

<400>  391

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ala Lys Gly Thr Arg Leu Leu Arg Tyr Asp Gly Thr 
    290                 295                 300                 


Glu Ile Asn Val Glu Asp Val Arg Glu Gly Asp Gln Leu Leu Gly Pro 
305                 310                 315                 320 


Asp Gly Glu Pro Arg Arg Ala Phe Asn Ile Val Ser Gly Ile Asp Arg 
                325                 330                 335     


Leu Tyr Arg Val Lys Ile Gly Gly Glu Lys Glu Asp Leu Val Val Thr 
            340                 345                 350         


Pro Asn His Ile Leu Val Phe Tyr Arg Glu Gly Pro Ser Asp Gly Pro 
        355                 360                 365             


Glu Asn Ala Glu Arg Gln Thr Val Glu Ile Thr Ala Ala Glu Phe Ala 
    370                 375                 380                 


Thr Leu Ser Thr Glu Glu Arg Ser Leu Tyr Ser Ala Phe Thr Ser Pro 
385                 390                 395                 400 


Ala Val Glu Lys Gly Ala Glu Gly Ser Ala Ala Gln Met His Ser Phe 
                405                 410                 415     


Lys Val Glu Asp Ile Ser Leu Glu Ser Glu Lys Thr Glu Trp Ala Gly 
            420                 425                 430         


Phe Arg Val Asp Lys Asp Gln Leu Tyr Leu Arg His Asp Tyr Leu Val 
        435                 440                 445             


Leu His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
    450                 455                 460                 


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
465                 470                 475                 480 


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
                485                 490                 495     


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
            500                 505                 510         


Ala Thr Arg 
        515 


<210>  392
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pfu_CDC21

<400>  392

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ala Pro Asp Ser Leu Val Val Val Asn Asp Lys Val 
    290                 295                 300                 


Gln Glu Ile Gly Lys Leu Thr Glu Glu Trp Gly Arg Glu Val Gly Phe 
305                 310                 315                 320 


Leu Glu Tyr Ser Ser Gly Ile Phe Tyr Ala Pro Tyr Leu Gly Arg Gly 
                325                 330                 335     


Ile Ser Leu Asp Leu Val Thr Gly Lys Val Lys Pro Ser Val Val Ser 
            340                 345                 350         


Lys Val Trp Lys Leu Lys Ser Pro Glu Glu Leu Val Thr Ile Lys Thr 
        355                 360                 365             


Ile Thr Gly Lys Glu Ile Thr Val Thr Pro Glu Thr Lys Leu Leu Thr 
    370                 375                 380                 


Phe Asn Gly Thr Leu Glu Trp Lys Glu Ala Gly Lys Ile Lys Pro Gly 
385                 390                 395                 400 


Asp Tyr Val Leu Thr Val Lys Lys Leu His Ile Asn Gly Lys Gln Glu 
                405                 410                 415     


Thr Leu Asp Glu Lys Leu Ala Tyr Lys Arg Gly Leu Ser Leu Ser Asp 
            420                 425                 430         


Pro Leu Glu Phe Phe Ser Ser Ser Glu Arg Thr Ile Ser Ala Tyr Leu 
        435                 440                 445             


Lys Gly Ile Phe Asp Lys Val Gly Arg Leu Val Gly Asp Thr Ala Val 
    450                 455                 460                 


Ile Lys Val Asp Lys Asp Met Ala Lys Arg Leu Gln Ile Leu Leu Leu 
465                 470                 475                 480 


Arg Leu Gly Ile Val Ser Ser Val Asp Glu Thr Gly Lys Val Ile Ile 
                485                 490                 495     


Gly Arg Glu Tyr Ile Gln Lys Ile Leu Gly Tyr Asn Val Ser Val Val 
            500                 505                 510         


Thr His Glu Val Glu Leu Phe Arg Glu Phe Ile Ala Glu Ile Ser Lys 
        515                 520                 525             


Phe Tyr Gly Thr Ser Glu Glu Asp Val Tyr Ser Ser Leu His Glu Lys 
    530                 535                 540                 


Gly Glu Leu Asp Ile Gly Thr Val Pro Val Glu Leu Pro Glu Gly Leu 
545                 550                 555                 560 


Arg Glu Glu Ile Asn Arg Glu Arg Ala Thr Tyr Ser Glu Leu Val Lys 
                565                 570                 575     


Ile Ala Gln Glu Ile Lys Asp Glu Lys Leu Tyr Asn Lys Leu Ala Trp 
            580                 585                 590         


Ile Leu Ser Glu Val Thr Glu Glu Glu Ala Lys Ile Lys Glu Lys Val 
        595                 600                 605             


Asn Thr Leu Lys Val Ile Leu Ser Ser Asp Leu Ile Pro Glu Arg Val 
    610                 615                 620                 


Glu Ser Val Lys Ile Ile Lys Ser Pro Tyr Pro Tyr Val Tyr Asp Leu 
625                 630                 635                 640 


Thr Val Glu Gly Ser His Ser Phe Ile Ala Asn Gly Phe Val Val His 
                645                 650                 655     


Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
            660                 665                 670         


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
        675                 680                 685             


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
    690                 695                 700                 


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
705                 710                 715                 720 


Arg 
    


<210>  393
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pfu_IF2

<400>  393

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Leu Pro Glu Glu Lys Val Val Leu Pro Glu Ile Gly 
    290                 295                 300                 


Leu Val Thr Leu Arg Glu Leu Phe Glu Leu Ala Asn Glu Val Val Val 
305                 310                 315                 320 


Lys Asp Glu Glu Lys Glu Val Arg Lys Leu Gly Lys Met Leu Thr Gly 
                325                 330                 335     


Val Asp Glu Arg Gly Asn Val Lys Leu Leu Asn Ala Leu Tyr Val Trp 
            340                 345                 350         


Arg Val Ala His Lys Gly Glu Met Ile Arg Val Lys Val Asn Gly Trp 
        355                 360                 365             


Tyr Ser Val Thr Val Thr Pro Glu His Pro Phe Leu Thr Asn Arg Gly 
    370                 375                 380                 


Trp Val Lys Ala Gly Glu Leu Lys Glu Gly Asp Tyr Ile Ala Ile Pro 
385                 390                 395                 400 


Arg Arg Val Tyr Gly Asn Glu Asp Leu Met Lys Phe Ser Lys Ile Ala 
                405                 410                 415     


Lys Glu Leu Gly Ile Lys Gly Asp Glu Lys Glu Phe Tyr Leu Ala Gly 
            420                 425                 430         


Ala Ser Leu Asp Ile Pro Ile Lys Val Leu Phe Leu Ala Pro Ser Lys 
        435                 440                 445             


Leu Val Ser Ala Phe Leu Arg Gly Tyr Phe Asp Ala Lys Gly Val Val 
    450                 455                 460                 


Arg Glu Asn Tyr Ile Glu Val Pro Leu Phe Glu Asp Leu Pro Leu Leu 
465                 470                 475                 480 


Leu Leu Arg Phe Gly Ile Val Ser Arg Ile Glu Lys Ser Thr Leu Lys 
                485                 490                 495     


Ile Ser Gly Lys Arg Asn Leu Glu Leu Phe Arg Lys His Val Gly Phe 
            500                 505                 510         


Thr Asp Ser Glu Lys Ala Lys Ala Leu Asp Glu Leu Ile Ser Lys Ala 
        515                 520                 525             


Lys Glu Ser Glu Arg Tyr Pro Ile Leu Glu Glu Leu Arg Arg Leu Gly 
    530                 535                 540                 


Leu Leu Phe Gly Phe Thr Arg Asn Glu Leu Arg Ile Glu Glu Asn Pro 
545                 550                 555                 560 


Thr Tyr Glu Val Leu Met Glu Ile Leu Glu Arg Ile Glu Arg Gly Ser 
                565                 570                 575     


Pro Asn Leu Ala Glu Lys Ile Ala Val Leu Glu Gly Arg Ile Lys Glu 
            580                 585                 590         


Glu Asn Tyr Leu Arg Ile Leu Glu Glu Glu Gly Leu Ile Glu Asn Gly 
        595                 600                 605             


Lys Leu Thr Glu Leu Gly Lys Glu Leu Leu Glu Val Trp Arg Asn Arg 
    610                 615                 620                 


Glu Phe Asp Ser Lys Asp Val Asp Tyr Val Arg Asn Ile Val Glu Asn 
625                 630                 635                 640 


Leu Val Phe Leu Pro Val Glu Lys Val Glu Arg Ile Glu Tyr Glu Gly 
                645                 650                 655     


Tyr Val Tyr Asp Val Thr Thr Glu Thr His Asn Phe Val Ala Asn Gly 
            660                 665                 670         


Ile Leu Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
        675                 680                 685             


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
    690                 695                 700                 


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
705                 710                 715                 720 


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
                725                 730                 735     


Glu Ala Ala Thr Arg 
            740     


<210>  394
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pfu_KlbA

<400>  394

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ala Leu Tyr Asp Phe Ser Val Ile Gln Leu Ser Asn Gly Arg 
    290                 295                 300                 


Phe Val Leu Ile Gly Asp Leu Val Glu Glu Leu Phe Lys Lys Tyr Ala 
305                 310                 315                 320 


Glu Lys Ile Lys Thr Tyr Lys Asp Leu Glu Tyr Ile Glu Leu Asn Glu 
                325                 330                 335     


Glu Asp Arg Phe Glu Val Val Ser Val Ser Pro Asp Leu Lys Ala Asn 
            340                 345                 350         


Lys His Val Val Ser Arg Val Trp Arg Arg Lys Val Arg Glu Gly Glu 
        355                 360                 365             


Lys Leu Ile Arg Ile Lys Thr Arg Thr Gly Asn Glu Ile Ile Leu Thr 
    370                 375                 380                 


Arg Asn His Pro Leu Phe Ala Phe Ser Asn Gly Asp Val Val Arg Lys 
385                 390                 395                 400 


Glu Ala Glu Lys Leu Lys Val Gly Asp Arg Val Ala Val Met Met Arg 
                405                 410                 415     


Pro Pro Ser Pro Pro Gln Thr Lys Ala Val Val Asp Pro Ala Ile Tyr 
            420                 425                 430         


Val Lys Ile Ser Asp Tyr Tyr Leu Val Pro Asn Gly Lys Gly Met Ile 
        435                 440                 445             


Lys Val Pro Asn Asp Gly Ile Pro Pro Glu Lys Ala Gln Tyr Leu Leu 
    450                 455                 460                 


Ser Val Asn Ser Tyr Pro Val Lys Leu Val Arg Glu Val Asp Glu Lys 
465                 470                 475                 480 


Leu Ser Tyr Leu Ala Gly Val Ile Leu Gly Asp Gly Tyr Ile Ser Ser 
                485                 490                 495     


Asn Gly Tyr Tyr Ile Ser Ala Thr Phe Asp Asp Glu Ala Tyr Met Asp 
            500                 505                 510         


Ala Phe Val Ser Val Val Ser Asp Phe Ile Pro Asn Tyr Val Pro Ser 
        515                 520                 525             


Ile Arg Lys Asn Gly Asp Tyr Thr Ile Val Thr Val Gly Ser Lys Ile 
    530                 535                 540                 


Phe Ala Glu Met Leu Ser Arg Ile Phe Gly Ile Pro Arg Gly Arg Lys 
545                 550                 555                 560 


Ser Met Trp Asp Ile Pro Asp Val Val Leu Ser Asn Asp Asp Leu Met 
                565                 570                 575     


Arg Tyr Phe Ile Ala Gly Leu Phe Asp Ala Asp Gly Tyr Val Asp Glu 
            580                 585                 590         


Asn Gly Pro Ser Ile Val Leu Val Thr Lys Ser Glu Thr Val Ala Arg 
        595                 600                 605             


Lys Ile Trp Tyr Val Leu Gln Arg Leu Gly Ile Ile Ser Thr Val Ser 
    610                 615                 620                 


Arg Val Lys Ser Arg Gly Phe Lys Glu Gly Glu Leu Phe Arg Val Ile 
625                 630                 635                 640 


Ile Ser Gly Val Glu Asp Leu Ala Lys Phe Ala Lys Phe Ile Pro Leu 
                645                 650                 655     


Arg His Ser Arg Lys Arg Ala Lys Leu Met Glu Ile Leu Arg Thr Lys 
            660                 665                 670         


Lys Pro Tyr Arg Gly Arg Arg Thr Tyr Arg Val Pro Ile Ser Ser Asp 
        675                 680                 685             


Met Ile Ala Pro Leu Arg Gln Met Leu Gly Leu Thr Val Ala Glu Leu 
    690                 695                 700                 


Ser Lys Leu Ala Ser Tyr Tyr Ala Gly Glu Lys Val Ser Glu Ser Leu 
705                 710                 715                 720 


Ile Arg His Ile Glu Lys Gly Arg Val Lys Glu Ile Arg Arg Ser Thr 
                725                 730                 735     


Leu Lys Gly Ile Ala Leu Ala Leu Gln Gln Ile Ala Lys Asp Val Gly 
            740                 745                 750         


Asn Glu Glu Ala Trp Val Arg Ala Lys Arg Leu Gln Leu Ile Ala Glu 
        755                 760                 765             


Gly Asp Val Tyr Trp Asp Glu Val Val Ser Val Glu Glu Val Asp Pro 
    770                 775                 780                 


Lys Glu Leu Gly Ile Glu Tyr Val Tyr Asp Leu Thr Val Glu Asp Asp 
785                 790                 795                 800 


His Asn Tyr Val Ala Asn Gly Ile Leu Val Ser Asn Ser Thr Tyr Ala 
                805                 810                 815     


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
            820                 825                 830         


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
        835                 840                 845             


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
    850                 855                 860                 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
865                 870                 875     


<210>  395
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pfu_Lon

<400>  395

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ser Gly Glu Glu Val Ile Leu Ile Glu Lys Asp Gly 
    290                 295                 300                 


Glu Lys Lys Val Phe Lys Leu Arg Glu Phe Val Asp Gly Leu Leu Lys 
305                 310                 315                 320 


Glu Ala Ser Gly Glu Gly Met Asp Gly Ser Ile Arg Val Val Tyr Lys 
                325                 330                 335     


Asp Leu Gln Gly Glu Asn Ile Lys Ile Leu Thr Lys Asp Gly Leu Val 
            340                 345                 350         


Lys Leu Leu Tyr Val Asn Arg Arg Glu Gly Lys Gln Lys Leu Arg Lys 
        355                 360                 365             


Ile Val Asn Leu Glu Lys Asp Tyr Trp Leu Ala Leu Thr Pro Glu His 
    370                 375                 380                 


Lys Val Tyr Thr Ile Lys Gly Leu Lys Glu Ala Gly Glu Ile Thr Lys 
385                 390                 395                 400 


Asp Asp Glu Ile Ile Arg Val Pro Leu Thr Ile Leu Asp Gly Phe Asp 
                405                 410                 415     


Val Ala Glu Lys Ser Ile Arg Glu Glu Leu Glu Arg Leu Ser Leu Leu 
            420                 425                 430         


Pro Leu Asn Ser Glu Asp Ser Arg Leu Glu Lys Ile Ala Gly Ile Met 
        435                 440                 445             


Gly Ala Leu Phe Gly Ser Gly Gly Ile Asp Glu Asn Leu Asn Thr Leu 
    450                 455                 460                 


Ser Phe Val Ser Ser Glu Lys Lys Thr Ile Glu Gln Phe Val Lys Ala 
465                 470                 475                 480 


Leu Ser Glu Leu Phe Gly Glu Phe Asp Tyr Lys Ile Glu Glu Lys Glu 
                485                 490                 495     


Asn Ser Ile Ile Phe Arg Thr Cys Asp Lys Arg Ile Val Thr Phe Phe 
            500                 505                 510         


Ala Thr Leu Gly Ala Pro Val Gly Asp Lys Ser Lys Val Lys Leu Lys 
        515                 520                 525             


Leu Pro Trp Trp Val Lys Leu Lys Pro Ser Leu Phe Leu Ala Phe Met 
    530                 535                 540                 


Asp Gly Leu Tyr Ser Ser Asn Arg Asn Asp Lys Glu Ile Leu Glu Ile 
545                 550                 555                 560 


Thr Gln Leu Thr Asp Asn Val Glu Thr Phe Phe Glu Glu Ile Ser Trp 
                565                 570                 575     


Tyr Leu Ser Phe Phe Gly Ile Lys Ala Glu Ala Glu Glu Asp Glu Glu 
            580                 585                 590         


Lys Asp Lys Tyr Arg Ala Arg Leu Thr Leu Ser Ser Ser Ile Asp Asn 
        595                 600                 605             


Met Leu Asn Phe Ile Glu Phe Ile Pro Ile Ser Phe Ser Pro Ala Lys 
    610                 615                 620                 


Arg Glu Lys Phe Phe Lys Glu Ile Glu Lys Tyr Leu Glu Tyr Ser Ile 
625                 630                 635                 640 


Pro Glu Lys Thr Glu Asp Leu Lys Lys Arg Val Lys Arg Val Lys Lys 
                645                 650                 655     


Gly Glu Arg Arg Asn Phe Leu Glu Ser Trp Glu Glu Val Glu Val Thr 
            660                 665                 670         


Tyr Asn Val Thr Thr Glu Thr Gly Asn Leu Leu Ala Asn Gly Leu Phe 
        675                 680                 685             


Val Lys Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
    690                 695                 700                 


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
705                 710                 715                 720 


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
                725                 730                 735     


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
            740                 745                 750         


Ala Thr Arg 
        755 


<210>  396
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pfu_RFC

<400>  396

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Gly Asp Thr Lys Val Ile Ala Asn Gly Gln Leu 
    290                 295                 300                 


Phe Glu Leu Gly Glu Leu Val Glu Lys Leu Ser Gly Gly Arg Phe Gly 
305                 310                 315                 320 


Pro Thr Pro Val Lys Gly Leu Lys Val Leu Gly Ile Asp Glu Asp Gly 
                325                 330                 335     


Lys Leu Arg Glu Phe Glu Val Gln Tyr Val Tyr Lys Asp Arg Thr Asp 
            340                 345                 350         


Arg Leu Ile Lys Ile Lys Thr Gln Leu Gly Arg Glu Leu Lys Val Thr 
        355                 360                 365             


Pro Tyr His Pro Leu Leu Val Asn Arg Glu Asn Gly Glu Ile Lys Trp 
    370                 375                 380                 


Ile Lys Ala Glu Glu Leu Lys Pro Gly Asp Lys Leu Ala Ile Pro Ser 
385                 390                 395                 400 


Phe Leu Pro Leu Ile Thr Gly Glu Asn Pro Leu Ala Glu Trp Leu Gly 
                405                 410                 415     


Tyr Phe Met Gly Ser Gly Tyr Ala Tyr Pro Ser Asn Ser Val Ile Thr 
            420                 425                 430         


Phe Thr Asn Glu Asp Pro Leu Ile Arg Gln Arg Phe Met Glu Leu Thr 
        435                 440                 445             


Glu Lys Leu Phe Pro Asp Ala Lys Ile Arg Glu Arg Ile His Ala Asp 
    450                 455                 460                 


Gly Thr Pro Glu Val Tyr Val Val Ser Arg Lys Ala Trp Ser Leu Val 
465                 470                 475                 480 


Asn Ser Ile Ser Leu Thr Leu Ile Pro Arg Glu Gly Trp Lys Gly Ile 
                485                 490                 495     


Arg Ser Phe Leu Arg Ala Tyr Ser Asp Cys Asn Gly Arg Ile Glu Ser 
            500                 505                 510         


Asp Ala Ile Val Leu Ser Thr Asp Asn Asn Asp Met Ala Gln Gln Ile 
        515                 520                 525             


Ala Tyr Ala Leu Ala Ser Phe Gly Ile Ile Ala Lys Met Asp Gly Glu 
    530                 535                 540                 


Asp Val Ile Ile Ser Gly Ser Asp Asn Ile Glu Arg Phe Leu Asn Glu 
545                 550                 555                 560 


Ile Gly Phe Ser Thr Gln Ser Lys Leu Lys Glu Ala Gln Lys Leu Ile 
                565                 570                 575     


Arg Lys Thr Asn Val Arg Ser Asp Gly Leu Lys Ile Asn Tyr Glu Leu 
            580                 585                 590         


Ile Ser Tyr Val Lys Asp Arg Leu Arg Leu Asn Val Asn Asp Lys Arg 
        595                 600                 605             


Asn Leu Ser Tyr Arg Asn Ala Lys Glu Leu Ser Trp Glu Leu Met Lys 
    610                 615                 620                 


Glu Ile Tyr Tyr Arg Leu Glu Glu Leu Glu Arg Leu Lys Lys Val Leu 
625                 630                 635                 640 


Ser Glu Pro Ile Leu Ile Asp Trp Asn Glu Val Ala Lys Lys Ser Asp 
                645                 650                 655     


Glu Val Ile Glu Lys Ala Lys Ile Arg Ala Glu Lys Leu Leu Glu Tyr 
            660                 665                 670         


Ile Lys Gly Glu Arg Lys Pro Ser Phe Lys Glu Tyr Ile Glu Ile Ala 
        675                 680                 685             


Lys Val Leu Gly Ile Asn Val Glu Arg Thr Ile Glu Ala Met Lys Ile 
    690                 695                 700                 


Phe Ala Lys Arg Tyr Ser Ser Tyr Ala Glu Ile Gly Arg Lys Leu Gly 
705                 710                 715                 720 


Thr Trp Asn Phe Asn Val Lys Thr Ile Leu Glu Ser Asp Thr Val Asp 
                725                 730                 735     


Asn Val Glu Ile Leu Glu Lys Ile Arg Lys Ile Glu Leu Glu Leu Ile 
            740                 745                 750         


Glu Glu Ile Leu Ser Asp Gly Lys Leu Lys Glu Gly Ile Ala Tyr Leu 
        755                 760                 765             


Ile Phe Leu Phe Gln Asn Glu Leu Tyr Trp Asp Glu Ile Thr Glu Val 
    770                 775                 780                 


Lys Glu Leu Arg Gly Asp Phe Ile Ile Tyr Asp Leu His Val Pro Gly 
785                 790                 795                 800 


Tyr His Asn Phe Ile Ala Gly Asn Met Pro Thr Val Val His Asn Ser 
                805                 810                 815     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            820                 825                 830         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        835                 840                 845             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    850                 855                 860                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
865                 870                 875                 


<210>  397
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pfu_TopA

<400>  397

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu His Pro Asp Thr Leu Ile Leu Thr Ser Gln Gly Val 
    290                 295                 300                 


Arg Lys Ile Lys Glu Leu Ser Arg Glu Gly Glu Val Phe Ala Leu Asp 
305                 310                 315                 320 


Phe Asn Leu Lys Leu Ser Lys Ala Lys Tyr Arg Leu Leu Glu Arg Asp 
                325                 330                 335     


Ala Asp Glu Gln Met Tyr Lys Val Thr Leu Leu Asp Gly Thr Glu Leu 
            340                 345                 350         


Tyr Leu Thr Ala Asp His Pro Val Leu Val Tyr Arg Glu Gly Asn Leu 
        355                 360                 365             


Ala Phe Val Pro Ala Asp Lys Leu Arg Glu Thr Asp His Val Val Leu 
    370                 375                 380                 


Val Leu Asn Lys Ser Ala Arg Asp Asn Tyr Gly Phe Leu Asp Leu Leu 
385                 390                 395                 400 


Leu Glu Ile Thr Asp Ser Gln Glu Asp Tyr Ala Ile Leu Glu Asn Gly 
                405                 410                 415     


Glu Thr Leu Ser Leu His Ser Leu Lys Met Leu Val Glu Arg Gly Glu 
            420                 425                 430         


Ile Lys Asp Ile Ala Val Val Gly Phe Ser His Asn Asn Phe Gly Lys 
        435                 440                 445             


Val Met Leu Arg Asp Glu Leu Trp Tyr Leu Ile Gly Tyr Leu Ala Gly 
    450                 455                 460                 


Lys Gly Gly Glu Ile Lys Gly Asn Gly Val Val Ile Ser Ser Arg Thr 
465                 470                 475                 480 


Lys Glu Ile Val Gly Leu Thr Lys Ser Leu Asn Ile Asp Leu Ile Glu 
                485                 490                 495     


Thr Glu Glu Gly Ile Val Leu Ser Asn Lys Ser Phe Val Arg Leu Leu 
            500                 505                 510         


His Leu Ile His Tyr Thr Pro Arg Val Pro Glu Val Tyr Gly Ile Ile 
        515                 520                 525             


Asn Asn Thr Glu Trp Leu Lys Ala Phe Leu Ala Gly Tyr Tyr Asp Ala 
    530                 535                 540                 


Thr Leu Leu Glu Gly Leu Thr Leu Glu Ala Leu Tyr Lys Ile Lys Val 
545                 550                 555                 560 


Tyr Leu Gln Leu Leu Gly Ile Arg Ala Lys Ile Glu Asp Asn Lys Leu 
                565                 570                 575     


Lys Val His Leu Glu Asp Leu Gln Arg Phe Arg Glu Leu Leu Gly Lys 
            580                 585                 590         


Phe Ser Arg Arg Lys Leu Tyr Val Glu Thr Ser Gln Val Pro Val Phe 
        595                 600                 605             


Thr Asp Phe Asp Glu Arg Ser Tyr Asp Phe Pro Arg Ile Leu Gly Gly 
    610                 615                 620                 


Asp Ile Tyr Ile Ile Gly Ile Lys Ser Ile Glu Lys Phe His Tyr Lys 
625                 630                 635                 640 


Gly Lys Val Tyr Asp Leu Val Val Glu Asn Tyr His Asn Phe Ile Ala 
                645                 650                 655     


Asn Gly Ile Ala Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
            660                 665                 670         


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
        675                 680                 685             


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
    690                 695                 700                 


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
705                 710                 715                 720 


Asn Ala Glu Ala Ala Thr Arg 
                725         


<210>  398
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pho_CDC21-2

<400>  398

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ala Pro Asp Thr Leu Ile Asn Thr Asp Asn Gly Arg 
    290                 295                 300                 


Val Glu Ile Gly Lys Phe Val Glu Glu Trp Met Lys Glu Val Gly Glu 
305                 310                 315                 320 


Ile Ser Glu Glu Gly Ile Ser Tyr Ala Pro Cys Phe Arg Lys Val Glu 
                325                 330                 335     


Thr Phe Lys Asp Gly Lys Ile Val Glu Ser Pro Ile Arg Arg Val Trp 
            340                 345                 350         


Lys Leu Arg Ala Pro Lys Lys Leu Val Arg Ile Lys Thr Glu Asn Gly 
        355                 360                 365             


Arg Ser Ile Ala Leu Thr Arg Glu Thr Lys Leu Leu Thr Ile Asn Asp 
    370                 375                 380                 


Gly Glu Leu Ser Trp Val Glu Ala Gly Glu Val Lys Val Gly Thr Tyr 
385                 390                 395                 400 


Val Gly Thr Val Lys Ser Glu Lys Asp Val Ile Pro Gly Ala Gly Lys 
                405                 410                 415     


Thr Ile Arg Asp Val Ser Lys Leu Tyr Asn Met Glu Met Glu Val Lys 
            420                 425                 430         


Asp Tyr Leu Thr Arg Glu Glu Val Arg Lys Ala Ile Glu Lys Leu Glu 
        435                 440                 445             


Glu Ile Met Asn Pro Met Asn Ile Lys Ile Pro Gly Val Gln Glu Ser 
    450                 455                 460                 


Tyr Glu Glu Leu Leu Arg Lys Leu Glu Thr Thr Asn Asp Glu Arg Val 
465                 470                 475                 480 


Arg Asn Glu Thr Leu Ile Leu Leu Ser Asp Val Ser Asp Ala His Glu 
                485                 490                 495     


Leu Ala Lys Glu Lys Ile Glu Lys Ile Lys Glu Ile Val Asn Ser Glu 
            500                 505                 510         


Val His Trp Glu Lys Val Thr Glu Val Gly Glu Val Asp Gly Val Glu 
        515                 520                 525             


Tyr Val Tyr Asp Leu Thr Val Glu Gly Ser His Asn Phe Val Ala Asn 
    530                 535                 540                 


Gly Phe Ile Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
545                 550                 555                 560 


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
                565                 570                 575     


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
            580                 585                 590         


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
        595                 600                 605             


Ala Glu Ala Ala Thr Arg 
    610                 


<210>  399
<211>  798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pho_IF2

<400>  399

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Leu Pro Glu Glu Arg Val Ile Leu Pro Asp Tyr Gly 
    290                 295                 300                 


Pro Ile Thr Leu Glu Glu Leu Phe Asn Met Thr Lys Glu Thr Val Phe 
305                 310                 315                 320 


Lys Asp Glu Glu Lys Glu Val Arg Lys Leu Gly Ile Arg Met Pro Val 
                325                 330                 335     


Ala Gly Val Asp Gly Arg Val Arg Leu Leu Glu Gly Pro Tyr Val Trp 
            340                 345                 350         


Lys Val Arg Tyr Lys Gly Lys Met Leu Arg Val Lys Leu Lys Asp Trp 
        355                 360                 365             


His Ser Val Ala Val Thr Pro Glu His Pro Phe Leu Thr Thr Arg Gly 
    370                 375                 380                 


Trp Val Arg Ala Asp Gln Leu Lys Pro Gly Asp Tyr Val Ala Val Pro 
385                 390                 395                 400 


Lys Ile Leu Pro Gly Lys Asp Asp Lys Glu Lys Phe Leu Gln Tyr Val 
                405                 410                 415     


His Glu Lys Leu Lys Gly Lys Val His Ile Lys Leu Pro Ser Ser Asp 
            420                 425                 430         


Glu Glu Trp Glu Thr Phe Phe Tyr Phe Ala Gly Thr Ile Phe Gly Arg 
        435                 440                 445             


Glu Asn Ser Val Asn Pro Glu Gly Leu Thr His Glu Val Lys Ala Leu 
    450                 455                 460                 


Leu Glu Leu Phe Lys Val Leu Phe Glu Tyr Pro Arg Glu Val Leu Arg 
465                 470                 475                 480 


Val Leu Phe Met Ala Pro Val Arg Tyr Val Ala Asn Phe Leu Arg Gly 
                485                 490                 495     


Phe Phe Asp Ile Asn Gly Tyr Val Asn Gly Glu Glu Leu Arg Val Glu 
            500                 505                 510         


Val Arg Gly Ala Pro His Glu Val Leu Glu Glu Leu Ser Leu Ile Leu 
        515                 520                 525             


Leu Arg Leu Gly Ile Val Ser Lys Ile Tyr Pro Thr Ser Leu Ala Ile 
    530                 535                 540                 


Ser Gly Arg Arg Asn Leu Glu Leu Phe Arg Arg Tyr Ile Gly Phe Ser 
545                 550                 555                 560 


Glu Lys Gln Lys Ala Lys Glu Leu Glu Gly Ile Ile Arg Arg Ser Glu 
                565                 570                 575     


Asn Ser Glu Ser Tyr Pro Ile Phe Glu Glu Leu Arg Arg Ile Arg Leu 
            580                 585                 590         


Leu Phe Gly Phe Thr Arg Ala Glu Leu Ser Ser Thr Ile Pro Leu Tyr 
        595                 600                 605             


Ser Lys Tyr Glu Ser Lys Glu Ala Pro Ser Tyr Glu Ile Leu Met Lys 
    610                 615                 620                 


Ile Leu Asn Thr Ile Glu Lys Gly Ser Lys Asp Leu Asn Lys Lys Ile 
625                 630                 635                 640 


Thr Ile Leu Glu Gly Arg Val Arg Asp His Glu Tyr Ile Glu Glu Phe 
                645                 650                 655     


Lys Arg Glu Gly Leu Ile Lys Asp Gly Lys Leu Thr Glu Leu Gly Lys 
            660                 665                 670         


Glu Leu Leu Glu Val Trp Arg Asn Arg Glu Phe Asp Ser Arg Asp Val 
        675                 680                 685             


Asn Tyr Leu Arg Asn Ile Ile Glu Asn Phe Val Phe Leu Pro Val Glu 
    690                 695                 700                 


Lys Ile Glu Glu Phe Glu Tyr Asp Gly Tyr Val Tyr Asp Val Thr Thr 
705                 710                 715                 720 


Glu Thr His Asn Phe Ile Ala Asn Gly Ile Leu Val His Asn Ser Thr 
                725                 730                 735     


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
            740                 745                 750         


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
        755                 760                 765             


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
    770                 775                 780                 


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795             


<210>  400
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pho_LHR

<400>  400

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ser Gly Asp Ser Lys Val Leu Thr Glu Lys Gly Pro 
    290                 295                 300                 


Val Glu Ile Arg His Leu Asn Ser Gly Met Ile Val Gly Ile Asn Gly 
305                 310                 315                 320 


Phe Lys Ser Arg Phe Val Lys Phe Gln Glu Leu His Gln Val Lys Tyr 
                325                 330                 335     


Gln Glu Tyr Gly Val Lys Ile Arg Thr Gln Leu Gly Phe Glu Val Lys 
            340                 345                 350         


Cys Thr Arg Glu His Arg Phe Leu Thr Ile Asp Lys Asn Gly Glu Leu 
        355                 360                 365             


Arg Trp Val Glu Ala Trp Arg Leu Lys Glu Gly Asp Tyr Val Gly Ile 
    370                 375                 380                 


Ile Arg Lys Leu Pro Ser Pro Asn Ser Lys Val Leu Ile Leu Asp Phe 
385                 390                 395                 400 


Leu Pro Glu Ser Thr Tyr Leu Trp Leu Asn Lys Glu Phe Leu Lys Lys 
                405                 410                 415     


Leu Lys Val Ser Ile Lys Glu Lys Phe Gly Ser Ile Lys Asn Tyr Ala 
            420                 425                 430         


Lys Glu Arg Gly Phe Asn Ser Ser Tyr Leu Val Lys Gln Leu Asn Gly 
        435                 440                 445             


Leu Ser Pro Phe Arg Trp Gly Arg Leu Arg Val Ile Leu Asn Asp Val 
    450                 455                 460                 


Ser Ile Glu Ile Ser Arg Asp Asp Ile Glu Arg Ile Thr Ser Arg Arg 
465                 470                 475                 480 


Gly Lys Tyr Ser Leu Pro Pro Glu Leu Thr Pro Gly Ile Ala Arg Leu 
                485                 490                 495     


Leu Gly Phe Trp Met Ala Ser Gly Ser Leu Asn Arg Asn Thr Leu Ile 
            500                 505                 510         


Phe Tyr Ser Gln Asp Lys Lys Ile Leu Glu Arg Tyr Glu Asp Leu Cys 
        515                 520                 525             


Lys Arg Glu Phe Arg Val Lys Gly Arg Ile Lys Ala Gln Asp Lys Gly 
    530                 535                 540                 


Thr Tyr Ile Leu Glu Ile Pro Ser Ser Leu Leu Ser Phe Val Phe Lys 
545                 550                 555                 560 


Asn Leu Ala Arg Pro Lys Leu Glu Val Pro Pro Ile Ile Tyr Ile Leu 
                565                 570                 575     


Pro Glu Lys His Lys Glu Glu Phe Leu Ala Gly Tyr Phe Asp Gly Asn 
            580                 585                 590         


Gly Phe Ile Lys Ile Glu Asn Gly Arg Ile His Ser Leu Gly Phe Phe 
        595                 600                 605             


Ala Phe Asn Arg Lys Phe Ala Glu Gly Ile Arg Asp Ile Leu Leu Gln 
    610                 615                 620                 


Leu Gly Ile Leu Ser Ser Ile Asn Glu Gln Thr Phe Glu Val Ser Ile 
625                 630                 635                 640 


Ile Glu Gly Glu Lys Phe Leu Lys Ile Val Asn Ser Trp Arg Ser Asn 
                645                 650                 655     


Tyr Tyr Lys Glu Trp Glu Asp Val Ile Pro Asn Leu Glu Lys Arg Leu 
            660                 665                 670         


Lys Glu Ile Glu Glu Lys Leu Gly Tyr Pro Gly Thr Tyr Asn Arg Arg 
        675                 680                 685             


Glu Ile Arg Arg Ser Glu Leu Lys Ala Ile Ile Lys Leu Tyr Glu Lys 
    690                 695                 700                 


Val Ala Arg Glu Arg Gly Leu Asn Asp Val Leu Lys Glu Leu Ser Tyr 
705                 710                 715                 720 


Leu Lys Glu Leu Ser Glu Gly Asp Ile Phe Phe Asp Arg Ile Thr Ser 
                725                 730                 735     


Ile Glu Pro Val Tyr Leu Asp Val Ala Tyr Gly Ile Ile Asn Ser Glu 
            740                 745                 750         


Thr Gly Asn Tyr Val Val Asn Gly Phe Val Ser Lys Asn Ser Thr Tyr 
        755                 760                 765             


Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
    770                 775                 780                 


Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile 
785                 790                 795                 800 


Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu 
                805                 810                 815     


Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            820                 825                 


<210>  401
<211>  828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pho_Lon

<400>  401

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ser Gly Glu Glu Val Ile Ile Val Glu Lys Gly Lys 
    290                 295                 300                 


Asp Arg Lys Val Val Lys Leu Arg Glu Phe Val Glu Asp Ala Leu Lys 
305                 310                 315                 320 


Glu Pro Ser Gly Glu Gly Met Asp Gly Asp Ile Lys Val Thr Tyr Lys 
                325                 330                 335     


Asp Leu Arg Gly Glu Asp Val Arg Ile Leu Thr Lys Asp Gly Phe Val 
            340                 345                 350         


Lys Leu Leu Tyr Val Asn Lys Arg Glu Gly Lys Gln Lys Leu Arg Lys 
        355                 360                 365             


Ile Val Asn Leu Asp Lys Asp Tyr Trp Leu Ala Val Thr Pro Asp His 
    370                 375                 380                 


Lys Val Phe Thr Ser Glu Gly Leu Lys Glu Ala Gly Glu Ile Thr Glu 
385                 390                 395                 400 


Lys Asp Glu Ile Ile Arg Val Pro Leu Val Ile Leu Asp Gly Pro Lys 
                405                 410                 415     


Ile Ala Ser Thr Tyr Gly Glu Asp Gly Lys Phe Asp Asp Tyr Ile Arg 
            420                 425                 430         


Trp Lys Lys Tyr Tyr Glu Lys Thr Gly Asn Gly Tyr Lys Arg Ala Ala 
        435                 440                 445             


Lys Glu Leu Asn Ile Lys Glu Ser Thr Leu Arg Trp Trp Thr Gln Gly 
    450                 455                 460                 


Ala Lys Pro Asn Ser Leu Lys Met Ile Glu Glu Leu Glu Lys Leu Asn 
465                 470                 475                 480 


Leu Leu Pro Leu Thr Ser Glu Asp Ser Arg Leu Glu Lys Val Ala Ile 
                485                 490                 495     


Ile Leu Gly Ala Leu Phe Ser Asp Gly Asn Ile Asp Arg Asn Phe Asn 
            500                 505                 510         


Thr Leu Ser Phe Ile Ser Ser Glu Arg Lys Ala Ile Glu Arg Phe Val 
        515                 520                 525             


Glu Thr Leu Lys Glu Leu Phe Gly Glu Phe Asn Tyr Glu Ile Arg Asp 
    530                 535                 540                 


Asn His Glu Ser Leu Gly Lys Ser Ile Leu Phe Arg Thr Trp Asp Arg 
545                 550                 555                 560 


Arg Ile Ile Arg Phe Phe Val Ala Leu Gly Ala Pro Val Gly Asn Lys 
                565                 570                 575     


Thr Lys Val Lys Leu Glu Leu Pro Trp Trp Ile Lys Leu Lys Pro Ser 
            580                 585                 590         


Leu Phe Leu Ala Phe Met Asp Gly Leu Tyr Ser Gly Asp Gly Ser Val 
        595                 600                 605             


Pro Arg Phe Ala Arg Tyr Glu Glu Gly Ile Lys Phe Asn Gly Thr Phe 
    610                 615                 620                 


Glu Ile Ala Gln Leu Thr Asp Asp Val Glu Lys Lys Leu Pro Phe Phe 
625                 630                 635                 640 


Glu Glu Ile Ala Trp Tyr Leu Ser Phe Phe Gly Ile Lys Ala Lys Val 
                645                 650                 655     


Arg Val Asp Lys Thr Gly Asp Lys Tyr Lys Val Arg Leu Ile Phe Ser 
            660                 665                 670         


Gln Ser Ile Asp Asn Val Leu Asn Phe Leu Glu Phe Ile Pro Ile Ser 
        675                 680                 685             


Leu Ser Pro Ala Lys Arg Glu Lys Phe Leu Arg Glu Val Glu Ser Tyr 
    690                 695                 700                 


Leu Ala Ala Val Pro Glu Ser Ser Leu Ala Gly Arg Ile Glu Glu Leu 
705                 710                 715                 720 


Arg Glu His Phe Asn Arg Ile Lys Lys Gly Glu Arg Arg Ser Phe Ile 
                725                 730                 735     


Glu Thr Trp Glu Val Val Asn Val Thr Tyr Asn Val Thr Thr Glu Thr 
            740                 745                 750         


Gly Asn Leu Leu Ala Asn Gly Leu Phe Val Lys Asn Ser Thr Tyr Ala 
        755                 760                 765             


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
    770                 775                 780                 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
785                 790                 795                 800 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
                805                 810                 815     


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            820                 825             


<210>  402
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pho_Pol_I

<400>  402

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Ile Leu Pro Asp Glu Trp Leu Pro Ile Val Glu Asn Glu 
    290                 295                 300                 


Lys Val Arg Phe Val Lys Ile Gly Asp Phe Ile Asp Arg Glu Ile Glu 
305                 310                 315                 320 


Glu Asn Ala Glu Arg Val Lys Arg Asp Gly Glu Thr Glu Ile Leu Glu 
                325                 330                 335     


Val Lys Asp Leu Lys Ala Leu Ser Phe Asn Arg Glu Thr Lys Lys Ser 
            340                 345                 350         


Glu Leu Lys Lys Val Lys Ala Leu Ile Arg His Arg Tyr Ser Gly Lys 
        355                 360                 365             


Val Tyr Ser Ile Lys Leu Lys Ser Gly Arg Arg Ile Lys Ile Thr Ser 
    370                 375                 380                 


Gly His Ser Leu Phe Ser Val Lys Asn Gly Lys Leu Val Lys Val Arg 
385                 390                 395                 400 


Gly Asp Glu Leu Lys Pro Gly Asp Leu Val Val Val Pro Gly Arg Leu 
                405                 410                 415     


Lys Leu Pro Glu Ser Lys Gln Val Leu Asn Leu Val Glu Leu Leu Leu 
            420                 425                 430         


Lys Leu Pro Glu Glu Glu Thr Ser Asn Ile Val Met Met Ile Pro Val 
        435                 440                 445             


Lys Gly Arg Lys Asn Phe Phe Lys Gly Met Leu Lys Thr Leu Tyr Trp 
    450                 455                 460                 


Ile Phe Gly Glu Gly Glu Arg Pro Arg Thr Ala Gly Arg Tyr Leu Lys 
465                 470                 475                 480 


His Leu Glu Arg Leu Gly Tyr Val Lys Leu Lys Arg Arg Gly Cys Glu 
                485                 490                 495     


Val Leu Asp Trp Glu Ser Leu Lys Arg Tyr Arg Lys Leu Tyr Glu Thr 
            500                 505                 510         


Leu Ile Lys Asn Leu Lys Tyr Asn Gly Asn Ser Arg Ala Tyr Met Val 
        515                 520                 525             


Glu Phe Asn Ser Leu Arg Asp Val Val Ser Leu Met Pro Ile Glu Glu 
    530                 535                 540                 


Leu Lys Glu Trp Ile Ile Gly Glu Pro Arg Gly Pro Lys Ile Gly Thr 
545                 550                 555                 560 


Phe Ile Asp Val Asp Asp Ser Phe Ala Lys Leu Leu Gly Tyr Tyr Ile 
                565                 570                 575     


Ser Ser Gly Asp Val Glu Lys Asp Arg Val Lys Phe His Ser Lys Asp 
            580                 585                 590         


Gln Asn Val Leu Glu Asp Ile Ala Lys Leu Ala Glu Lys Leu Phe Gly 
        595                 600                 605             


Lys Val Arg Arg Gly Arg Gly Tyr Ile Glu Val Ser Gly Lys Ile Ser 
    610                 615                 620                 


His Ala Ile Phe Arg Val Leu Ala Glu Gly Lys Arg Ile Pro Glu Phe 
625                 630                 635                 640 


Ile Phe Thr Ser Pro Met Asp Ile Lys Val Ala Phe Leu Lys Gly Leu 
                645                 650                 655     


Asn Gly Asn Ala Glu Glu Leu Thr Phe Ser Thr Lys Ser Glu Leu Leu 
            660                 665                 670         


Val Asn Gln Leu Ile Leu Leu Leu Asn Ser Ile Gly Val Ser Asp Ile 
        675                 680                 685             


Lys Ile Glu His Glu Lys Gly Val Tyr Arg Val Tyr Ile Asn Lys Lys 
    690                 695                 700                 


Glu Ser Ser Asn Gly Asp Ile Val Leu Asp Ser Val Glu Ser Ile Glu 
705                 710                 715                 720 


Val Glu Lys Tyr Glu Gly Tyr Val Tyr Asp Leu Ser Val Glu Asp Asn 
                725                 730                 735     


Glu Asn Phe Leu Val Gly Phe Gly Leu Leu Tyr Ala His Asn Ser Thr 
            740                 745                 750         


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
        755                 760                 765             


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
    770                 775                 780                 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
785                 790                 795                 800 


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                805                 810                 


<210>  403
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pho_RadA

<400>  403

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Arg Asp Thr Glu Val Tyr Tyr Glu Asn Asp Thr 
    290                 295                 300                 


Val Pro His Met Glu Ser Ile Glu Glu Met Tyr Ser Lys Tyr Ala Ser 
305                 310                 315                 320 


Met Asn Gly Glu Leu Pro Phe Asp Asn Gly Tyr Ala Val Pro Leu Asp 
                325                 330                 335     


Asn Val Phe Val Tyr Thr Leu Asp Ile Ala Ser Gly Glu Ile Lys Lys 
            340                 345                 350         


Thr Arg Ala Ser Tyr Ile Tyr Arg Glu Lys Val Glu Lys Leu Ile Glu 
        355                 360                 365             


Ile Lys Leu Ser Ser Gly Tyr Ser Leu Lys Val Thr Pro Ser His Pro 
    370                 375                 380                 


Val Leu Leu Phe Arg Asp Gly Leu Gln Trp Val Pro Ala Ala Glu Val 
385                 390                 395                 400 


Lys Pro Gly Asp Val Val Val Gly Val Arg Glu Glu Val Leu Arg Arg 
                405                 410                 415     


Arg Ile Ile Ser Lys Gly Glu Leu Glu Phe His Glu Val Ser Ser Val 
            420                 425                 430         


Arg Ile Ile Asp Tyr Asn Asn Trp Val Tyr Asp Leu Val Ile Pro Glu 
        435                 440                 445             


Thr His Asn Phe Ile Ala Pro Asn Gly Leu Val Leu His Asn Ser Thr 
    450                 455                 460                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
465                 470                 475                 480 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                485                 490                 495     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            500                 505                 510         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        515                 520                 525     


<210>  404
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pho_r-Gyr

<400>  404

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Pro Asp Thr Leu Val Ser Leu Ser Asp Gly Arg 
    290                 295                 300                 


Ile Ile Glu Ile Arg Glu Ala Val Glu Asn Ser Glu Glu Ser Leu Leu 
305                 310                 315                 320 


Gly Ile Asn Gly Leu Lys Pro Lys Glu Ala Lys Ala Leu Lys Phe Trp 
                325                 330                 335     


Glu Ile Asp Trp Asp Gly Pro Ile Lys Val Ile Lys Leu Lys Asn Gly 
            340                 345                 350         


His Glu Ile Lys Ala Thr Pro Asp His Gly Leu Leu Val Met Arg Asp 
        355                 360                 365             


Gly Lys Ile Gly Trp Val Ser Ala Lys Asn Ile Arg Glu Gly Asp Tyr 
    370                 375                 380                 


Val Ala Phe Ile Tyr Asn Leu Gly His Arg Gly Gly Lys Lys Tyr Thr 
385                 390                 395                 400 


Leu Pro Gln Leu Leu Lys Glu Leu Gly Ile Ser Glu Tyr Glu Asn Ser 
                405                 410                 415     


Ser Ser Gln Glu Leu Asn Asn Arg Glu Gln Glu Met Asp Ser Lys Gln 
            420                 425                 430         


Ile Ser Ile Glu Leu Asp Glu Arg Phe Trp Tyr Ile Phe Gly Val Ile 
        435                 440                 445             


Leu Gly Lys Gly Thr Leu Lys Gly Asp Lys Val Val Ile Phe Gln Lys 
    450                 455                 460                 


Asp Val Lys Pro Val Ile Glu Glu Ala Leu Pro Phe Val Arg Ile Phe 
465                 470                 475                 480 


Glu Ser Ala Asp His Ile Gly Phe Ser His Leu Ile Leu Ala Glu Val 
                485                 490                 495     


Phe Arg Arg Leu Gly Val Gly Glu Gly Lys Leu His Ser Leu Val Phe 
            500                 505                 510         


Gly Leu Arg Glu Glu Tyr Ile Asn Ala Met Ile Ala Gly Tyr Phe Asp 
        515                 520                 525             


Ala Ser Gly Thr Phe Leu Arg Arg Ala Val Leu Thr Ser Lys Arg Gly 
    530                 535                 540                 


Asp Ile Leu Arg Met Leu Ser Val Tyr Leu Tyr Gln Ile Gly Ile Val 
545                 550                 555                 560 


Asn Asn Leu Arg Arg Asp Glu His Ala Gly Val Trp Glu Leu Ile Ile 
                565                 570                 575     


Ser Asp Leu Glu Lys Phe Arg Glu Lys Ile Tyr Pro Tyr Leu Arg Ile 
            580                 585                 590         


Lys Lys Ser Gln Phe Asp Lys Val Tyr Ser Ile Ser Lys Asn Glu Gly 
        595                 600                 605             


Asp Phe Leu Pro Val Ala Ser Ile Phe Arg Lys Leu Lys Phe Arg Asp 
    610                 615                 620                 


Gly Phe Lys Asn Arg Ile Leu Asp Glu Glu Ile Pro Arg Asp Glu Val 
625                 630                 635                 640 


Ala Lys Val Leu Glu Tyr Ala Glu Asp Ser Pro Glu Lys Glu Phe Leu 
                645                 650                 655     


Asn Ser Leu Val Glu Ala Arg Val Thr Trp Val Arg Val Glu Lys Ile 
            660                 665                 670         


Glu Glu Arg His Tyr Thr Gly Lys Leu Tyr Asp Phe Thr Thr Thr Thr 
        675                 680                 685             


Glu Asn Phe Ile Ser Asn Gly Ile Val Ser His Asn Ser Thr Tyr Ala 
    690                 695                 700                 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
705                 710                 715                 720 


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
                725                 730                 735     


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
            740                 745                 750         


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760                 


<210>  405
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Pho_RtcB_Pho_Hyp-2

<400>  405

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ala Pro Gly Thr Arg Val Leu Thr Glu His Gly Tyr 
    290                 295                 300                 


Trp Leu Lys Ile Glu Glu Met Pro Glu Lys Phe Lys Leu Gln Arg Leu 
305                 310                 315                 320 


Arg Val Tyr Asn Ile Glu Glu Gly His Asn Asp Phe Ser Lys Val Val 
                325                 330                 335     


Phe Val Ala Glu Arg Glu Val Gly Ser Glu Glu Lys Ala Ile Arg Ile 
            340                 345                 350         


Val Thr Glu Ser Gly Lys Val Ile Glu Gly Ser Glu Asp His Pro Val 
        355                 360                 365             


Leu Thr Pro Glu Gly Tyr Val Tyr Leu Arg Asn Val Lys Glu Gly Asp 
    370                 375                 380                 


Tyr Ile Leu Val Tyr Pro Phe Glu Gly Val Pro Tyr Glu Glu Lys Lys 
385                 390                 395                 400 


Gly Val Ile Leu Asp Glu Ser Ala Phe Glu Gly Glu Asp Pro Gln Val 
                405                 410                 415     


Val Lys Phe Leu Arg Glu Arg Asn Leu Ile Pro Leu Gln Trp Lys Asp 
            420                 425                 430         


Pro Lys Val Gly Ile Leu Ala Arg Ile Leu Gly Phe Ala Leu Ala Asn 
        435                 440                 445             


Gly Tyr Ile Ser Glu Asn Asp Asn Leu Thr Phe His Gly Lys Glu Glu 
    450                 455                 460                 


Val Leu Arg Glu Val Arg Lys Asp Leu Glu Glu Leu Gly Ile Glu Ala 
465                 470                 475                 480 


Ile Val Ala Glu Glu Asp Lys Leu Lys Val Thr Ser Arg Glu Phe Ala 
                485                 490                 495     


Phe Leu Leu Glu Lys Leu Gly Met Ala His Asp Ser Ile Pro Glu Trp 
            500                 505                 510         


Ile Ile Glu Gly Pro Leu Trp Ile Lys Arg Asn Phe Leu Ala Gly Leu 
        515                 520                 525             


Phe Gly Ala Asn Gly Ser Ile Val Glu Phe Lys Gly Asp Val Pro Leu 
    530                 535                 540                 


Pro Ile Thr Leu Thr His Ser Arg Glu Leu Leu Asn Asp Val Ser Arg 
545                 550                 555                 560 


Ile Leu Glu Gly Phe Lys Val Arg Ala Lys Ile Lys Met Gly Lys Asn 
                565                 570                 575     


Gly Ser Tyr Gln Leu Val Ile Glu Asp Glu Asp Ser Ile Arg Asn Phe 
            580                 585                 590         


Leu Gly Arg Ile Asn Tyr Glu Tyr Asp Pro Glu Lys Lys Ala Arg Gly 
        595                 600                 605             


Leu Ile Ala Tyr Ala Tyr Leu Lys Phe Lys Glu Leu Met Lys Gly Asn 
    610                 615                 620                 


Leu Met Thr Phe Glu Glu Phe Ala Arg Asp Arg Gly Tyr Glu Gly Gly 
625                 630                 635                 640 


Phe Val Ala Glu Lys Val Ile Glu Val Lys Ser Val Lys Pro Glu Tyr 
                645                 650                 655     


Asp Lys Phe Tyr Asp Ile Gly Val Tyr His Ser Ala His Asn Phe Ile 
            660                 665                 670         


Ala Asn Gly Ile Val Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
        675                 680                 685             


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
    690                 695                 700                 


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
705                 710                 715                 720 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
                725                 730                 735     


Val Asn Ala Glu Ala Ala Thr Arg 
            740                 


<210>  406
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pho_VMA

<400>  406

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Asp Gly Asp Thr Leu Val Leu Thr Lys Glu Phe Gly 
    290                 295                 300                 


Leu Ile Lys Ile Lys Glu Leu Tyr Glu Lys Leu Asp Gly Lys Gly Arg 
305                 310                 315                 320 


Lys Ile Val Glu Gly Asn Glu Glu Trp Thr Glu Leu Glu Lys Pro Ile 
                325                 330                 335     


Thr Val Tyr Gly Tyr Lys Asp Gly Lys Ile Val Glu Ile Lys Ala Thr 
            340                 345                 350         


His Val Tyr Lys Gly Val Ser Ser Gly Met Val Glu Ile Arg Thr Arg 
        355                 360                 365             


Thr Gly Arg Lys Ile Lys Val Thr Pro Ile His Arg Leu Phe Thr Gly 
    370                 375                 380                 


Arg Val Thr Lys Asp Gly Leu Ile Leu Lys Glu Val Met Ala Met His 
385                 390                 395                 400 


Val Lys Pro Gly Asp Arg Ile Ala Val Val Lys Lys Ile Asp Gly Gly 
                405                 410                 415     


Glu Tyr Ile Lys Leu Asp Ser Ser Asn Val Gly Glu Ile Lys Val Pro 
            420                 425                 430         


Glu Ile Leu Asn Glu Glu Leu Ala Glu Phe Leu Gly Tyr Leu Met Ala 
        435                 440                 445             


Asn Gly Thr Leu Lys Ser Gly Ile Ile Glu Ile Tyr Cys Asp Asp Glu 
    450                 455                 460                 


Ser Leu Leu Glu Arg Val Asn Ser Leu Ser Leu Lys Leu Phe Gly Val 
465                 470                 475                 480 


Gly Gly Arg Ile Val Gln Lys Val Asp Gly Lys Ala Leu Val Ile Gln 
                485                 490                 495     


Ser Lys Pro Leu Val Asp Val Leu Arg Arg Leu Gly Val Pro Glu Asp 
            500                 505                 510         


Lys Lys Val Glu Asn Trp Lys Val Pro Arg Glu Leu Leu Leu Ser Pro 
        515                 520                 525             


Ser Asn Val Val Arg Ala Phe Val Asn Ala Tyr Ile Lys Gly Lys Glu 
    530                 535                 540                 


Glu Val Glu Ile Thr Leu Ala Ser Glu Glu Gly Ala Tyr Glu Leu Ser 
545                 550                 555                 560 


Tyr Leu Phe Ala Lys Leu Gly Ile Tyr Val Thr Ile Ser Lys Ser Gly 
                565                 570                 575     


Glu Tyr Tyr Lys Val Arg Val Ser Arg Arg Gly Asn Leu Asp Thr Ile 
            580                 585                 590         


Pro Val Glu Val Asn Gly Met Pro Lys Val Leu Pro Tyr Glu Asp Phe 
        595                 600                 605             


Arg Lys Phe Ala Lys Ser Ile Gly Leu Glu Glu Val Ala Glu Asn His 
    610                 615                 620                 


Leu Gln His Ile Ile Phe Asp Glu Val Ile Asp Val Arg Tyr Ile Pro 
625                 630                 635                 640 


Glu Pro Gln Glu Val Tyr Asp Val Thr Thr Glu Thr His Asn Phe Val 
                645                 650                 655     


Gly Gly Asn Met Pro Thr Leu Leu His Asn Ser Thr Tyr Ala Ser Leu 
            660                 665                 670         


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
        675                 680                 685             


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
    690                 695                 700                 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
705                 710                 715                 720 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730 


<210>  407
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pna_RIR1

<400>  407

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Ala Asp Thr Arg Leu Ala Thr Gln His Gly Leu 
    290                 295                 300                 


Val Pro Ile Gly Trp Leu Gln Ala Asn Gly Gly Ala Leu Asp Cys Thr 
305                 310                 315                 320 


Val Asp Arg Arg Ala Leu Gly Glu Asp Arg Arg Gly Thr Val Thr Arg 
                325                 330                 335     


Ala Ala Val Pro Ala Phe Leu Ser Ala Gly Gln Ala Glu Val Phe Lys 
            340                 345                 350         


Val Thr Thr Ala Glu Gly Tyr Gln Ile Lys Ala Thr Ala Trp His Glu 
        355                 360                 365             


Phe Tyr Thr Ala Arg Gly Lys Leu Lys Leu Ser Glu Leu Lys Ala Gly 
    370                 375                 380                 


Asp Glu Leu Trp Val Gln Ser Gly Lys Gly Gln Phe Gly Ala Gln Gly 
385                 390                 395                 400 


Ser Gly Ala Leu Gly Leu Leu Ile Gly Leu Ile Thr Gly Asp Gly His 
                405                 410                 415     


Phe Thr Asn Arg Gly Lys Asp Glu Gln Ala Ala Val Ile Ser Leu Trp 
            420                 425                 430         


Gly Glu Glu Arg Gln Leu Ala Asp Asp Ile Ala Gly Ser Val Asn Ala 
        435                 440                 445             


Leu Ile Ala Gly Thr Ser Leu Ala Pro Arg Asp Tyr Leu Val Lys Pro 
    450                 455                 460                 


Val Ala Val Ala Glu Arg Asn Met Val Phe Ile Arg Ser Thr Met Leu 
465                 470                 475                 480 


Val Arg Val Leu Asp Gly Tyr Gly Phe Asn Gly Glu Thr Lys Leu Glu 
                485                 490                 495     


Val Pro Glu Val Val Trp Arg Gly Ser Glu Ala Cys Met Arg Gly Tyr 
            500                 505                 510         


Leu Gln Gly Leu Phe Gln Thr Asp Gly Thr Val Asn Val Ser Ser Asn 
        515                 520                 525             


Ser Gln Ser Cys Ser Val Arg Leu Ser Ser Ser His Arg Pro Leu Leu 
    530                 535                 540                 


Gln Asp Val Gln Val Leu Leu Ala Asn Phe Gly Val Phe Ser Arg Ile 
545                 550                 555                 560 


His Glu Arg Arg Glu Ala Gly Pro Arg Ser Leu Pro Asp Gly Gln Gly 
                565                 570                 575     


Gly Gln Arg Asp Tyr Leu Cys Gln Thr Gln His Glu Leu Ile Val Asp 
            580                 585                 590         


Gly Glu Ser Arg Glu Ala Phe Met Arg Glu Ile Gly Phe Leu Leu Pro 
        595                 600                 605             


Ala Lys Arg Glu Lys Tyr Asp Ala Trp Val Ala Asp Lys Ala Leu Val 
    610                 615                 620                 


Lys Thr Gln Arg Phe Ala Ala Thr Ile Thr Ala Ile Glu Pro Ala Gly 
625                 630                 635                 640 


Val Glu Pro Val Tyr Asp Thr Thr Gln Pro Asp Gly Asn Thr Val Ile 
                645                 650                 655     


Phe Asn Gly Leu Val Thr Gly Gln Ser Thr Tyr Ala Ser Leu Asn Gly 
            660                 665                 670         


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
        675                 680                 685             


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
    690                 695                 700                 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
705                 710                 715                 720 


Val Asn Ala Glu Ala Ala Thr Arg 
                725             


<210>  408
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pno_RPA2

<400>  408

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ser Ala Asp His Glu Val Leu Thr Ser Thr Gly Trp 
    290                 295                 300                 


Lys Ala Leu Pro Ala Ile Lys Asp Ala Asp Gln Val Met Thr Leu Asp 
305                 310                 315                 320 


Leu Gln Thr Gly Thr Gln Gln Trp Asn Ser Val Gln Ala Thr Thr Arg 
                325                 330                 335     


Phe Ala Arg Glu Gly Ser Leu Tyr Arg Leu Lys Ser Asp Asp Met Asp 
            340                 345                 350         


Ala Val Cys Asn Glu Ser His Arg Trp Tyr Leu Asn Thr Lys Asp Gln 
        355                 360                 365             


Pro Thr Thr Tyr Thr Ala Phe Thr Thr Gln Gln Met Leu Asp Asn Gln 
    370                 375                 380                 


Leu Val Ala Leu Arg Asn Ser Ser Gly Lys Ala Thr Asp Gln Trp Asn 
385                 390                 395                 400 


His Glu Ser Gly Thr Thr Thr His Thr Asn His Asn Ile Pro Thr Val 
                405                 410                 415     


Gly His Asn Gly Asn Val Met Phe Ser Trp Pro Asp Cys Pro Trp Leu 
            420                 425                 430         


Pro Arg Glu Phe Val Ala Asp Glu Ala Cys Asn Leu Asp Trp Cys Arg 
        435                 440                 445             


Phe Ile Gly Leu Val Met Gly Asp Gly Ser Ile Asp His Val Thr Asp 
    450                 455                 460                 


Ala Gln Gly Gln Glu His Tyr Ser Ile Gln Ile His Gln Arg Ala Gly 
465                 470                 475                 480 


Asn Pro Ala Ser Asn Ala Asn Thr Glu Asp Val Leu Glu Arg Leu Ala 
                485                 490                 495     


Ala Lys Leu Pro Asn Phe Val Val His Pro Ser Cys Val Ser Gly Ala 
            500                 505                 510         


Glu Glu Lys His Thr Trp Thr Ile Asn His Arg Asp Met Tyr His Phe 
        515                 520                 525             


Phe Leu Pro Met Met Arg Gly Pro Gln Ser Tyr Asp Pro Leu Asp Asn 
    530                 535                 540                 


Ala Met Cys Arg Thr Tyr Gln Ala Pro Asp Tyr Gln Ala Leu Ser Arg 
545                 550                 555                 560 


Ser Asp Asn Glu Pro Ile Ile Pro Val Pro Ala Asp Trp Lys Thr Gly 
                565                 570                 575     


Asn Trp Trp His Leu Arg Arg Trp Ile Asn Tyr Pro Trp Leu Phe Ser 
            580                 585                 590         


Leu Ala Gln Ser Gln Ala Arg Ala Met Ile Lys Gly Met Ala Ala Ala 
        595                 600                 605             


Asn Gly Asp Trp Ser Leu Ser Leu Lys Ala Arg Leu Asp Thr Gly Asp 
    610                 615                 620                 


Ser Gly Val Val Arg Val Phe Ser Asn Ser Ile Pro Leu Met His Asp 
625                 630                 635                 640 


Met Ser Val Leu Gly Leu Leu Ala Asp Thr Arg Val Asn Ile Gly Val 
                645                 650                 655     


Asp His Lys Lys Gly Gln Met Gln Leu Gln Val Pro Val Thr Met Pro 
            660                 665                 670         


Ala Leu Leu Ala Trp Cys Ile Ser Phe Ser Phe Ala Asn Ser Asp Leu 
        675                 680                 685             


Ala Val Ala Ala Pro Lys Pro Glu Ala Tyr Asp Asn Pro Arg His Asp 
    690                 695                 700                 


Gly Phe Val Tyr Cys Leu Thr Val Pro Asn Gly Asn Phe Leu Ala Arg 
705                 710                 715                 720 


Arg Thr Val Glu Tyr Ser Asp Asn Asp Lys Ile Gln Glu Val Ile Asp 
                725                 730                 735     


Ala Ala Gln Lys Pro Phe Phe Thr Gly Asn Ser Thr Tyr Ala Ser Leu 
            740                 745                 750         


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
        755                 760                 765             


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
    770                 775                 780                 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
785                 790                 795                 800 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                805                 810 


<210>  409
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Posp-JS666_RIR1

<400>  409

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Ala Asp Thr Trp Val Met Thr Thr Ala Gly Pro 
    290                 295                 300                 


Ala Gln Val Ser Glu Leu Thr Gly Arg Ser Phe Ser Ala Val Val Asp 
305                 310                 315                 320 


Gly Lys Ala Tyr Ala Val Thr Ser Asp Gly Phe Phe Arg Thr Gly His 
                325                 330                 335     


Lys Pro Val Leu Ala Leu Arg Thr Arg Glu Gly Pro Ala Leu Arg Leu 
            340                 345                 350         


Thr Ala Asp His Arg Val Arg Arg Val Ala Arg Arg Thr Arg Tyr Thr 
        355                 360                 365             


Leu Glu Ala Glu Trp Thr Glu Ala Gly Gln Leu Gln Pro Gly Asp Glu 
    370                 375                 380                 


Ile Leu Leu His Asp His Arg Ala Leu Gly Gly Trp Glu Gly Ala Gly 
385                 390                 395                 400 


Thr His Ala Glu Gly Tyr Leu Leu Gly Leu Leu Ile Gly Asp Gly Thr 
                405                 410                 415     


Leu Lys Ser Asp Lys Ala Val Ile Ser Val Trp Ala Pro Glu Leu Lys 
            420                 425                 430         


Val Ala Gly Gly Gly Ala Val Ala Tyr Ala Gln Thr Gly Ala Gly Gly 
        435                 440                 445             


Ile Val Gln Ala Ala Glu Ala Ala Ala Ala Thr Leu Ser His Arg Val 
    450                 455                 460                 


Asp Phe Arg Gly Phe Gln Arg Ser Ile Ser Gly Arg Gly Glu Ala Arg 
465                 470                 475                 480 


Met Ala Ser Gly Ala Val Arg His Leu Ala His Glu Met Gly Met Arg 
                485                 490                 495     


Pro Gly His Lys Thr Ile Thr Thr Ala Met Glu Lys Ala Ser Ser Val 
            500                 505                 510         


Phe Thr Glu Gly Leu Leu Arg Gly Leu Phe Asp Ala Asp Gly Ser Val 
        515                 520                 525             


Gln Gly Ser Gln Glu Lys Gly Val Ser Leu Arg Leu Ser Gln Ser Asp 
    530                 535                 540                 


Leu Ser Leu Leu Gln Thr Ala Gln Arg Met Leu Leu Arg Leu Gly Ile 
545                 550                 555                 560 


Ala Ser Thr Ile Tyr Pro Asn Arg Arg Leu Ala Gln Ala Arg Pro Leu 
                565                 570                 575     


Pro Asp Gly Arg Gly Gly Leu Arg Val Tyr Glu Thr Ala Ser Gln His 
            580                 585                 590         


Glu Leu Val Ile Ser Ala Asp Asn Leu Arg Ile Tyr Ala Glu Arg Ile 
        595                 600                 605             


Gly Phe Ala Asp Thr Asp Lys Ala Asp Arg Leu Asp Gln Ala Leu Gly 
    610                 615                 620                 


Ser Tyr Asn Arg Ser Leu Asn Arg Glu Arg Phe Thr Val Thr Val Glu 
625                 630                 635                 640 


Ser Leu Thr Glu Glu Gly Ser Glu Asp Val Phe Asp Val Thr Val Ala 
                645                 650                 655     


Asp Ile His Ala Phe Asp Ala Asn Gly Leu Tyr Val His Asn Ser Thr 
            660                 665                 670         


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
        675                 680                 685             


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
    690                 695                 700                 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
705                 710                 715                 720 


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730                 


<210>  410
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:PP-PhiEL_ORF39

<400>  410

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ala Gly Val Leu Ser Ser Lys Ile Lys Ile Pro Gly Gly Trp 
    290                 295                 300                 


Lys Thr Met Gly Asn Ile Arg Val Gly Asp Glu Val Val Thr Pro Asp 
305                 310                 315                 320 


Gly Gly Thr Ala Lys Val Leu Ala Val His Pro Gln Gly Val Thr Lys 
                325                 330                 335     


Val Val Arg Val His Phe Lys Asp Gly Arg Tyr Thr Asp Val Ser Pro 
            340                 345                 350         


Asp His Leu Trp Lys Val Arg Arg His His Trp Cys Asn Asp Lys Ala 
        355                 360                 365             


Met Ala Lys Leu Thr Arg Glu Glu Val Glu Glu Arg Val Trp Arg Val 
    370                 375                 380                 


Ile Thr Thr Asn Glu Leu Lys Asp Tyr Ile Gly Leu Ser Thr Lys Val 
385                 390                 395                 400 


Tyr Val Gln Leu Ile Glu Pro Glu Arg Asn Ala Asp Lys Pro Phe Lys 
                405                 410                 415     


Ile His Pro Tyr Val Leu Gly Val Leu Leu Gly Asp Gly Cys Ile Ser 
            420                 425                 430         


Gln Lys Ala Val Asp Ile Thr Lys Pro Tyr Gln Gln Leu Phe Asp Lys 
        435                 440                 445             


Val Gln Ser Leu Leu Pro Glu His Leu Glu Cys Val Trp Arg Pro Asn 
    450                 455                 460                 


Arg Lys Gly Asp Gly Glu Pro Lys Thr Phe Gly Ile Arg Phe Lys Asp 
465                 470                 475                 480 


Arg Arg Ser Glu Gln His Ile Asn Trp His Ile Arg Asp Gly Leu Lys 
                485                 490                 495     


Glu Leu Gly Leu Tyr Gly Met Arg Ser Trp Gly Lys Val Ile Pro Glu 
            500                 505                 510         


Glu Tyr Leu His Gly Ser Ala Lys Gln Arg Leu Glu Leu Leu Gln Gly 
        515                 520                 525             


Leu Leu Asp Thr Asp Gly Thr Val Asp Lys His Lys Ser Val Ser Phe 
    530                 535                 540                 


Ser Ser Ser Ser Lys Leu Leu Ser Leu Gly Val Gln Tyr Leu Val Arg 
545                 550                 555                 560 


Ser Leu Gly Gly Met Ala Arg Leu Gln Glu Arg Thr Pro His Tyr Thr 
                565                 570                 575     


His Asn Gly Glu Lys Arg Glu Gly Arg Thr Asp Tyr Arg Val Tyr Ile 
            580                 585                 590         


Arg Tyr Pro Arg Pro Glu Glu Leu Phe Thr Leu Asp His Lys Arg Glu 
        595                 600                 605             


Arg Ala Val Ser His Gln His Thr Glu Thr Leu Arg Leu Gln Val Thr 
    610                 615                 620                 


His Ile Glu Glu Arg Pro Asp Glu Glu Thr Gln Cys Ile Thr Ile Asp 
625                 630                 635                 640 


His Pro Asp His Leu Tyr Ile Thr Asp Asp Phe Ile Val Thr His Asn 
                645                 650                 655     


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
            660                 665                 670         


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
        675                 680                 685             


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
    690                 695                 700                 


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
705                 710                 715                 720 


<210>  411
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pst_VMA

<400>  411

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Lys Gly Thr Lys Val Leu Met Ala Asn Gly Asp 
    290                 295                 300                 


Asp Lys Asn Ile Glu Asp Ile Ala Val Gly Glu Glu Val Leu Gly Lys 
305                 310                 315                 320 


Asp Gly Leu Pro Arg Glu Val Val Ala Leu Pro Arg Gly Arg Glu Thr 
                325                 330                 335     


Met Tyr Glu Val Ser Glu Lys Thr Gln His Arg Ala Glu Thr Val Phe 
            340                 345                 350         


Gly Thr Ala Ser Tyr Thr Cys Asn Ala Thr His Lys Leu Val Leu Gln 
        355                 360                 365             


Thr Asn Gln Arg Val Asn Ile Thr Asn His Val Leu Arg Gly Glu Ser 
    370                 375                 380                 


Gln Thr Ser Val Thr Tyr Phe Gln Met Lys Thr Ala Val Ala Asp Gly 
385                 390                 395                 400 


Arg Glu Ile Glu Leu Pro Lys Leu Cys Thr Lys Ser Phe Gln His Ser 
                405                 410                 415     


Ser His Gly Arg Glu Asn Ala Trp Lys Lys Ala Glu Val Phe Ala Ser 
            420                 425                 430         


Thr Ile Ser Arg Asp Pro Ile Asp Trp Thr Ala Glu Ala Arg Asp Ile 
        435                 440                 445             


Ser Arg Leu Gly Tyr His Val Arg Arg Ala Thr Arg Gln Leu Trp Ser 
    450                 455                 460                 


Pro Val Leu Val Glu Lys Glu Val Leu Ala Pro Met Ile Ala Lys Arg 
465                 470                 475                 480 


Gly Phe Asp Glu Ser Ile Ala Pro Tyr Met Ala Tyr Leu Val Gly Leu 
                485                 490                 495     


Trp Val Gly Asp Gly Tyr Ser Asp Arg Ala Thr Phe Ser Ile Asp Ile 
            500                 505                 510         


Gln Asp Val Glu Ile His Glu Arg Ile Lys Asp Phe Ala Ser His Ala 
        515                 520                 525             


Gly Leu Thr Pro Arg Ile Ala Cys Tyr Lys Lys Ser Arg Asp Ala Thr 
    530                 535                 540                 


Ile Ser Leu His Asn Ser Glu Thr Arg Gly Lys Asn Val Arg Gln Asn 
545                 550                 555                 560 


Leu Asn Thr Gly Asn Leu Leu Trp Ser Leu Leu Ala Glu Ile Cys Gly 
                565                 570                 575     


Lys Lys Glu Asn Glu Met Leu Phe Lys Leu Val Pro Ser Phe Leu Arg 
            580                 585                 590         


Ser Glu Ser Ile Ala Val Arg Glu Tyr Phe Ile Ser Gly Leu Val Asp 
        595                 600                 605             


Ser Asp Gly His Val Lys Arg Asp Glu Ala Asp Lys Cys Tyr Ser Ala 
    610                 615                 620                 


Thr Val Lys Thr Ile Tyr Pro Ala Val Arg Asp Gly Leu Val Ser Val 
625                 630                 635                 640 


Ala Arg Ser Leu Gly Ile Gln Thr Ser Val Ser Val Glu Glu Ala Lys 
                645                 650                 655     


Glu Val Asn Ser Val Lys His Gln Glu Ser Tyr Ala Ile Tyr Met Ala 
            660                 665                 670         


Asn Ser Ser Ala Leu Asp Ser Val Leu Ser Lys Cys Ala Ala Pro Arg 
        675                 680                 685             


Lys Arg Ala Glu Glu Pro Val Cys Val Asn Arg Glu Pro His Pro Tyr 
    690                 695                 700                 


Thr Phe His Met Val Glu Lys Glu Glu Asp Asp Phe Tyr Gly Ile Thr 
705                 710                 715                 720 


Leu Ser Glu Asp Ser Asp His Gln Phe Leu Leu Ser Asn Leu Ala Leu 
                725                 730                 735     


Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
            740                 745                 750         


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
        755                 760                 765             


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
    770                 775                 780                 


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
785                 790                 795                 800 


Ala Thr Arg 
            


<210>  412
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Rma_DnaB

<400>  412

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ala Gly Asp Thr Leu Ile Thr Leu Ala Asp Gly Arg 
    290                 295                 300                 


Arg Val Pro Ile Arg Glu Leu Val Ser Gln Gln Asn Phe Ser Val Trp 
305                 310                 315                 320 


Ala Leu Asn Pro Gln Thr Tyr Arg Leu Glu Arg Ala Arg Val Ser Arg 
                325                 330                 335     


Ala Phe Cys Thr Gly Ile Lys Pro Val Tyr Arg Leu Thr Thr Arg Leu 
            340                 345                 350         


Gly Arg Ser Ile Arg Ala Thr Ala Asn His Arg Phe Leu Thr Pro Gln 
        355                 360                 365             


Gly Trp Lys Arg Val Asp Glu Leu Gln Pro Gly Asp Tyr Leu Ala Leu 
    370                 375                 380                 


Pro Arg Arg Ile Pro Thr Ala Ser Thr Pro Thr Leu Thr Glu Ala Glu 
385                 390                 395                 400 


Leu Ala Leu Leu Gly His Leu Ile Gly Asp Gly Cys Thr Leu Pro His 
                405                 410                 415     


His Val Ile Gln Tyr Thr Ser Arg Asp Ala Asp Leu Ala Thr Leu Val 
            420                 425                 430         


Ala His Leu Ala Thr Lys Val Phe Gly Ser Lys Val Thr Pro Gln Ile 
        435                 440                 445             


Arg Lys Glu Leu Arg Trp Tyr Gln Val Tyr Leu Arg Ala Ala Arg Pro 
    450                 455                 460                 


Leu Ala Pro Gly Lys Arg Asn Pro Ile Ser Asp Trp Leu Arg Asp Leu 
465                 470                 475                 480 


Gly Ile Phe Gly Leu Arg Ser Tyr Glu Lys Lys Val Pro Ala Leu Leu 
                485                 490                 495     


Phe Cys Gln Thr Ser Glu Ala Ile Ala Thr Phe Leu Arg His Leu Trp 
            500                 505                 510         


Ala Thr Asp Gly Cys Ile Gln Met Arg Arg Gly Lys Lys Pro Tyr Pro 
        515                 520                 525             


Ala Val Tyr Tyr Ala Thr Ser Ser Tyr Gln Leu Ala Arg Asp Val Gln 
    530                 535                 540                 


Ser Leu Leu Leu Arg Leu Gly Ile Asn Ala Arg Leu Lys Thr Val Ala 
545                 550                 555                 560 


Gln Gly Glu Lys Gly Arg Val Gln Tyr His Val Lys Val Ser Gly Arg 
                565                 570                 575     


Glu Asp Leu Leu Arg Phe Val Glu Lys Ile Gly Ala Val Gly Ala Arg 
            580                 585                 590         


Gln Arg Ala Ala Leu Ala Ser Val Tyr Asp Tyr Leu Ser Val Arg Thr 
        595                 600                 605             


Gly Asn Pro Asn Arg Asp Ile Ile Pro Val Ala Leu Trp Tyr Glu Leu 
    610                 615                 620                 


Val Arg Glu Ala Met Tyr Gln Arg Gly Ile Ser His Arg Gln Leu His 
625                 630                 635                 640 


Ala Asn Leu Gly Met Ala Tyr Gly Gly Met Thr Leu Phe Arg Gln Asn 
                645                 650                 655     


Leu Ser Arg Ala Arg Ala Leu Arg Leu Ala Glu Ala Ala Ala Cys Pro 
            660                 665                 670         


Glu Leu Arg Gln Leu Ala Gln Ser Asp Val Tyr Trp Asp Pro Ile Val 
        675                 680                 685             


Ser Ile Glu Pro Asp Gly Val Glu Glu Val Phe Asp Leu Thr Val Pro 
    690                 695                 700                 


Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Ala His Asn Ser Thr 
705                 710                 715                 720 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
                725                 730                 735     


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
            740                 745                 750         


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
        755                 760                 765             


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780         


<210>  413
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Rsp_Rir1

<400>  413

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Ala Glu Thr Trp Val Met Thr Asp Glu Gly Ala 
    290                 295                 300                 


Arg Gln Val Ser Ala Leu Leu Asp Arg Pro Phe Arg Ala Val Val Asn 
305                 310                 315                 320 


Gly Ile Ala Tyr Asp Ser Gly Glu His Gly Phe Phe Cys Thr Gly Leu 
                325                 330                 335     


Lys Pro Val Lys Arg Leu Ser Thr Ala Cys Gly Arg His Leu Arg Leu 
            340                 345                 350         


Thr Ala Asp His Leu Val Arg Lys Val Val Gly Lys Thr Arg Trp Arg 
        355                 360                 365             


Gln Glu Val Glu Trp Val Pro Ala Gly Asp Leu Arg Pro Gly Asp Glu 
    370                 375                 380                 


Val Lys Leu His Asp His Arg Thr Ala Met Ile Gln Thr Arg Pro Glu 
385                 390                 395                 400 


Asp Glu Arg Gly Tyr Leu Leu Gly Leu Leu Ile Gly Asp Gly Val Ile 
                405                 410                 415     


Arg Asp Asp Lys Thr Leu Ile Ser Val Trp Pro Gln Glu Glu Cys Ile 
            420                 425                 430         


Gly Ala Gln Pro Leu Gly His Pro Val Met His Lys Val Glu Ala Leu 
        435                 440                 445             


Leu Arg Asp Leu Pro His Arg Ala Asp Phe Ala Gly Trp Gln Lys Val 
    450                 455                 460                 


Glu Gly Arg Gly Glu Tyr Arg Ile Gly Thr Ala Ala Leu Thr Ala Leu 
465                 470                 475                 480 


Ala Ala Glu Tyr Gly Leu Thr Arg Gly Arg Lys Thr Ile Thr Pro Glu 
                485                 490                 495     


Ile Glu Gly Ala Glu Thr Ala Gly Phe Gly Ala Ala Val Leu Arg Gly 
            500                 505                 510         


Leu Phe Asp Ala Asp Gly Ser Val Gln Gly Ala Gln Glu Lys Gly Val 
        515                 520                 525             


Ser Val Arg Leu Ala Gln Ser Asp Leu Ala Leu Leu Gln Ala Ala Gln 
    530                 535                 540                 


Arg Met Leu Ala Arg Leu Gly Met Asn Ala Val Ile Tyr Glu Asn Arg 
545                 550                 555                 560 


Arg Glu Ala Gly Arg Ala Phe Leu Pro Asp Gly Lys Gly Gly Gln Ala 
                565                 570                 575     


His Phe Glu Thr Lys Ala Gln His Glu Leu Val Ile Ser Gly Glu Asn 
            580                 585                 590         


Leu Ala Thr Tyr Gln Glu Arg Ile Gly Phe Thr Asp Val Ala Lys Ala 
        595                 600                 605             


Arg Arg Leu Ala Val Ala Leu Ser Gly Tyr Lys Arg Ala Leu Asn Arg 
    610                 615                 620                 


Glu Arg Phe Ser Ala Val Val Ala Asp Val Val Asp Asp Gly Met Ala 
625                 630                 635                 640 


Glu Val Phe Asp Val Gln Val Pro Gly Val Asn Ala Phe Asp Ala Asn 
                645                 650                 655     


Gly Phe Tyr Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
            660                 665                 670         


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
        675                 680                 685             


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
    690                 695                 700                 


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
705                 710                 715                 720 


Ala Glu Ala Ala Thr Arg 
                725     


<210>  414
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:SaP-SETP3_Helicase

<400>  414

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Lys Arg Gly Thr Glu Val Ile Met Phe Asp Gly Thr 
    290                 295                 300                 


Thr Lys Lys Val Glu Asp Val Ile Val Gly Asp Val Leu Met Gly Pro 
305                 310                 315                 320 


Asp Ser Thr Pro Arg Asn Val Leu Ser Leu Gly Arg Gly Arg Glu Met 
                325                 330                 335     


Met Tyr Glu Val Lys Pro Arg Lys Gly Glu Ser Tyr Thr Val Asn Glu 
            340                 345                 350         


Ser His Ile Leu Ser Leu Arg Thr Thr Thr Gly Ile Ala Lys Gly Ser 
        355                 360                 365             


Trp Pro Asp Asn Thr Val Phe Asp Ile Ser Val Arg Asp Trp Leu Lys 
    370                 375                 380                 


Leu Pro Lys Tyr Val Thr Gly Pro Asn Gly Tyr Leu Lys Gly Trp Arg 
385                 390                 395                 400 


Val Pro Val Asp Phe Pro Arg Lys Glu Gln Asp Glu Ala Leu Leu Pro 
                405                 410                 415     


Pro Tyr Leu Met Gly Leu Trp Leu Gly Asp Gly Thr Ser Ser Ser Gly 
            420                 425                 430         


Ala Ile Thr Ser Gly Glu Asn Glu Lys Glu Ile Arg Ala Tyr Leu Glu 
        435                 440                 445             


Ser Tyr Ala Ala Arg Asn Gly Met Gln Ile Arg Lys Glu Gly Leu Thr 
    450                 455                 460                 


Trp Ser Ile Ser His Gly Asn Thr Gly His Lys Lys His Gly Phe Thr 
465                 470                 475                 480 


His Ala Leu Lys Ser Ala Gly Val Leu Asn Asn Lys His Ile Pro His 
                485                 490                 495     


Asn Tyr Lys Cys Gly Asp Arg Arg Gln Arg Leu Glu Leu Leu Ala Gly 
            500                 505                 510         


Leu Leu Asp Ser Asp Gly Tyr Cys Asp Leu Ser Lys Ala Gly Phe Asp 
        515                 520                 525             


Trp Ile Ser Val Ser Glu Arg Leu Ala Asp Asp Phe Cys Tyr Leu Cys 
    530                 535                 540                 


Arg Ser Leu Gly Phe Ala Ala Tyr Lys Lys Lys Thr Cys Lys Arg Cys 
545                 550                 555                 560 


Ala Asn Thr Asp Val Trp Gly Asp Tyr Phe Arg Val Ser Val Ser Gly 
                565                 570                 575     


Asp Phe Ser Glu Val Pro Phe Val Arg Gly Arg His Gln Asn Leu Pro 
            580                 585                 590         


Lys Arg Asn Ile Asn Lys Asn Val Leu Asn Val Gly Ile Glu Ser Ile 
        595                 600                 605             


Thr Pro Val Gly Val Asp Asp Tyr Phe Gly Phe Thr Ile Asp Gly Asp 
    610                 615                 620                 


Ser Arg Phe Leu Leu Gly Asp Phe Thr Val Thr His Asn Thr Ser Thr 
625                 630                 635                 640 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
                645                 650                 655     


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
            660                 665                 670         


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
        675                 680                 685             


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695                 700         


<210>  415
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Sav_Helicase

<400>  415

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ala Gln Pro Leu Asp Ser Leu Val Leu Ala Pro Thr Gly Phe 
    290                 295                 300                 


Arg Arg Met Gly Asp Leu Arg Glu Gly Asp Glu Val Val Val Pro Asn 
305                 310                 315                 320 


Gly Glu Ile Ala Leu Ile Asp Gly Val Phe Pro Gln Gly Val Arg Asp 
                325                 330                 335     


Val Trp Arg Ile Val Leu Ser Asp Gly Ser Ser Val Glu Cys Asp Asp 
            340                 345                 350         


Glu His Leu Trp Ile Val Gly Thr Ser Cys Gly Trp His Arg Gly Gln 
        355                 360                 365             


Thr Pro Lys Val Met Thr Thr Arg Glu Ile Arg Leu Asp Thr Phe Lys 
    370                 375                 380                 


Ala Asn Gly Ser Ser Lys Trp Tyr Val Pro Ala Ala Thr Pro Val Asp 
385                 390                 395                 400 


Leu Gly Pro Asp Val Gly Leu Pro Leu Asp Pro Tyr Leu Phe Gly Leu 
                405                 410                 415     


Leu Leu Gly Asp Gly Ser Phe Arg His Asn Leu Arg Leu Ser Thr Val 
            420                 425                 430         


Asp Asp Glu Ile Arg Asp Ala Ala Ala Asp Ala Val Ala Pro Asp Cys 
        435                 440                 445             


Arg Leu Val Pro Val Thr Gly Ser Arg Cys Asp Tyr Thr Ile Gln Leu 
    450                 455                 460                 


Lys Gln Arg Ser Gly Gly Val Arg Asn Pro Val Ile Gln Ala Leu Arg 
465                 470                 475                 480 


Arg Leu Asp Leu Trp Gly Lys Thr Ser His Gly Lys Phe Ile Pro Glu 
                485                 490                 495     


Asp Phe Lys Asn Thr Ser Ile Lys Asn Arg Leu Ser Leu Leu Gln Gly 
            500                 505                 510         


Leu Leu Asp Thr Asp Gly Thr Val His Ala Asp Gly Met Ser Val Ser 
        515                 520                 525             


Leu Arg Ser Ala Ser Leu Arg Leu Ala Glu Asp Val Ala Trp Leu Val 
    530                 535                 540                 


Arg Ser Leu Gly Gly Arg Ala Arg Val Leu Pro Glu Lys Ala Ala Phe 
545                 550                 555                 560 


His Val Ser Val Ala Leu Pro Asp Glu Tyr Ala Pro Phe Arg Leu Ser 
                565                 570                 575     


Arg Lys Ala Asp Arg Val Arg Pro Arg Pro Lys Tyr Asn Thr Phe Arg 
            580                 585                 590         


Arg Gly Ile Arg Ala Val Glu Tyr Val Gly Arg Lys Pro Ala Gln Cys 
        595                 600                 605             


Ile Ser Val Gly His Pro Ser His Ala Tyr Val Thr Asp Asn Phe Thr 
    610                 615                 620                 


Val Thr His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
625                 630                 635                 640 


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
                645                 650                 655     


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
            660                 665                 670         


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
        675                 680                 685             


Ala Ala Thr Arg 
    690         


<210>  416
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Sex-IFO1128_VMA

<400>  416

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Lys Gly Thr Gln Val Met Met Ala Asp Gly Ser 
    290                 295                 300                 


Asp Lys Ser Ile Glu Asp Ile Gln Leu Gly Glu Asn Val Met Gly Lys 
305                 310                 315                 320 


Asp Gly Thr Pro Arg Thr Val Ile Ser Leu Pro Arg Gly Lys Glu Thr 
                325                 330                 335     


Met Tyr Glu Val Cys His Ser Ser Thr Lys Gly Thr Thr Lys Asp Thr 
            340                 345                 350         


Leu Met Asn Tyr Val Cys Ser Gly Asn His Lys Ile Val Met Gln Thr 
        355                 360                 365             


Pro Gln Gln Ile Gly Ile Thr Glu His Gly Ile Asp Gly Lys Thr Tyr 
    370                 375                 380                 


Thr Ser Val Ser Tyr Phe Ala Leu Arg Asp Ser Gln His Gly Tyr Pro 
385                 390                 395                 400 


Ile Val Lys Lys Leu Thr Lys Ser Phe Glu His Gln Gln His Gly Gly 
                405                 410                 415     


Lys Glu Gln Thr Leu Ile Thr Val Asn Asn Phe Val Ser Ser Leu Lys 
            420                 425                 430         


Ser Glu Pro Ile Asn Trp Asp Val Glu Ala Lys His Tyr Glu Ser Leu 
        435                 440                 445             


Gly His Tyr Val Lys Lys Cys Ser Tyr Gln Leu Ile Asn Pro Val Phe 
    450                 455                 460                 


His Gln Ser Gly Lys Leu Ala Gln Glu Ile Ala Ser Leu Asn Tyr Ser 
465                 470                 475                 480 


Lys Asp Lys Ala Pro Leu Leu Ala Trp Leu Ile Gly Phe Trp Val Gly 
                485                 490                 495     


Asn Gly Ala Met Arg His Ser Gln Phe Val Val Glu Ser Gln Asp Ile 
            500                 505                 510         


Glu Leu Val Asn Arg Ile Gln Asp Ile Ala Gly Leu Leu Asn Leu Ser 
        515                 520                 525             


Ala Thr Thr Ala Cys Tyr Tyr Ser Gly Ser Lys Asp Asp Glu Ala Lys 
    530                 535                 540                 


Leu Ala Lys Leu Asn Ser Ser Ser Ala Glu Gly Phe Glu Asp Asp Leu 
545                 550                 555                 560 


Glu Gly Asn Pro Ser Val Lys Glu Leu Ala Asp Met Asp Arg Leu Ser 
                565                 570                 575     


Glu Ser Lys Thr Ala Thr Leu Pro Thr Ala Phe Gly Val Glu Asn Ile 
            580                 585                 590         


Asp Glu Leu Ile Ile Ser Leu Gly Glu Gly Arg Gly Asn Gly Asn Val 
        595                 600                 605             


Phe Ala Gln Val Ile Gly Ser Phe Gly Ile Asp Leu Ala Asp Lys Asp 
    610                 615                 620                 


Thr Leu Val Thr Lys Ile Ala His Glu Leu Ala Gly Asp Ala Phe Glu 
625                 630                 635                 640 


Val Arg Glu Gln Phe Val Ala Gly Leu Val Asp Ala Ala Gly Tyr Val 
                645                 650                 655     


Arg Lys Asp Val Tyr Asp His Ala Ser Glu Ala Thr Ile Ser Thr Glu 
            660                 665                 670         


Ser Lys Ser Thr Val Leu Gly Leu Val Lys Ile Ala Arg Ser Leu Gly 
        675                 680                 685             


Ile Lys Ile Thr Val Thr Ser Asp Asp Ser Asp Asp Ser Asp Glu His 
    690                 695                 700                 


Asp His Ala His Cys Gly His Asp His Gly Ser Ser Ser Ser Tyr Thr 
705                 710                 715                 720 


Ala Val Met Thr Gly Asp Ala Leu Thr Asn Ser Met Arg Phe Cys Ala 
                725                 730                 735     


Ile Gly Arg Asn Arg Val Ala Ala Lys Glu Phe Met Arg Gln Ala Val 
            740                 745                 750         


Pro Phe Tyr Phe Ser Leu Glu Lys Lys Ser Glu Asp Asp Tyr Tyr Gly 
        755                 760                 765             


Ile Thr Val Pro Asp Asn Thr Asp Lys Gln Tyr Leu Leu Ser Ser Met 
    770                 775                 780                 


Ala Leu Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
785                 790                 795                 800 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                805                 810                 815     


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            820                 825                 830         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        835                 840                 845             


Glu Ala Ala Thr Arg 
    850             


<210>  417
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Smar_1471

<400>  417

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Val Ser Tyr Asp Thr Pro Val Leu Ile Arg Asp Pro Ile 
    290                 295                 300                 


Asn Lys Ile His Leu Val Lys Ile Gly Glu Phe Ile Asp Lys Phe Tyr 
305                 310                 315                 320 


Glu Glu Gly Glu Glu Arg Thr Ala Lys His Val Asn Gly Tyr Tyr Val 
                325                 330                 335     


Leu Ser His Asp Gly Phe Gln Val Val Trp Lys Pro Ile Lys Tyr Val 
            340                 345                 350         


Leu Arg His Arg Thr Asn Glu Ile Tyr Glu Ile Ile Tyr Glu Gly Gly 
        355                 360                 365             


Gly Lys Leu Glu Ala Thr Gly Ser His Ser Val Phe Val Leu Asp Pro 
    370                 375                 380                 


Asp Thr Leu Asp Ile Val Glu Lys Pro Val Met Leu Leu Asn Lys Gly 
385                 390                 395                 400 


Glu Tyr Leu Val Ser Phe Asn Gly Val Lys Glu Asn Lys Asp His Gln 
                405                 410                 415     


Thr Ile Asp Leu Ile Asp Leu Val Ser Asp Tyr Asn Asp Val Tyr Val 
            420                 425                 430         


Asp Asn Ile Pro Ser Glu Leu Lys Lys His Thr Gly Gly Arg Asn Pro 
        435                 440                 445             


Ile Pro Leu Lys Gln Tyr Met Ile Leu Arg Lys Arg Val Ile Thr Lys 
    450                 455                 460                 


Lys Asn Asn Ser Leu Ile Lys Leu Arg Arg Ser Lys Tyr Thr Leu Pro 
465                 470                 475                 480 


Ile Arg Leu Val Leu Asp Glu Lys Leu Ala Phe Leu Phe Gly Ala Tyr 
                485                 490                 495     


Ile Ala Asn Gly Cys Val Lys Glu Arg Arg Asp Lys Leu Ile Cys Phe 
            500                 505                 510         


Thr Phe Gly Lys Ser Ala Lys Asn Ile Ala Asp Lys Val Met Asn Ile 
        515                 520                 525             


Met Tyr Glu Lys Phe Asn Ile Lys Pro Phe Ile Asp Asp Arg Gly Thr 
    530                 535                 540                 


Tyr Ile Ile Tyr Glu Tyr Pro His Thr Leu Leu Ala Ile Ile Phe Glu 
545                 550                 555                 560 


Lys Leu Leu Gly Arg Lys Leu Glu Glu Lys Lys Met Pro Glu Ile Leu 
                565                 570                 575     


Trp Ser Ser Pro Lys Ser Val Ile Arg Ala Phe Phe Glu Gly Leu Arg 
            580                 585                 590         


Ala Tyr Ser Gln Arg Thr Leu Arg Arg Arg Tyr Thr Ser Tyr Thr Thr 
        595                 600                 605             


Ala Asn Lys Asn Leu Ala Tyr Gln Leu Leu Trp Leu Ala Arg Phe Ala 
    610                 615                 620                 


Gly Phe Tyr Ser Val Leu Lys Glu Glu Lys Glu Ala Gly Lys Asn Asn 
625                 630                 635                 640 


Gly Lys Thr Tyr Tyr His Val Ile Val Tyr Leu Asp Gln Ser Tyr Arg 
                645                 650                 655     


Lys Pro Asn Ala Ser Glu Arg Val Pro Val Lys Pro Ile Leu Lys Leu 
            660                 665                 670         


Ile Lys Tyr Thr Lys Pro Arg Thr Met Pro Pro Glu Leu Ala Tyr Ile 
        675                 680                 685             


Lys Arg Arg Glu Phe Ile Ser Arg Lys Thr Ala Leu Lys Ala Leu Glu 
    690                 695                 700                 


Trp Ile Arg Arg Asp Gly Ser Phe Thr Asp Phe Ser Arg Glu Tyr Leu 
705                 710                 715                 720 


Arg Lys Ile Glu Ser Leu Ile Asn Gly Asp Ile Ile Val Leu Lys Ile 
                725                 730                 735     


Lys Asp Val Arg Lys Lys Gln Tyr Lys Gly Tyr Val Tyr Asp Ile Ser 
            740                 745                 750         


Val Pro Ile Thr Glu Ala Phe Phe Gly Gly Asn Ile Pro Ile Leu Leu 
        755                 760                 765             


His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
    770                 775                 780                 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
785                 790                 795                 800 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                805                 810                 815     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            820                 825                 830         


Thr Arg 
        


<210>  418
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Smar_MCM2

<400>  418

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Tyr His Lys Asp Phe Lys Ile Met Leu Ala Asp Gly Arg 
    290                 295                 300                 


Lys Val Arg Ile Gly Asp Leu Val Asp Glu Leu Ile Gly Lys Asn Arg 
305                 310                 315                 320 


Glu Lys Val Ile Lys Gly Lys Asp Thr Glu Ile Leu Phe Val Asp Asp 
                325                 330                 335     


Leu Phe Leu Leu Ser Tyr Asn Met Arg Ser Gly Glu Gln Val Leu Val 
            340                 345                 350         


Lys Ala Asp Arg Val Ser Arg His Lys Ala Pro Asp Gln Phe Ile Lys 
        355                 360                 365             


Leu Arg Phe Ser Asn Gly Ala Glu Ile Ile Val Thr Pro Glu His Pro 
    370                 375                 380                 


Val Leu Ile Ile Asn Asn Gly Lys Ile Lys Thr Val Arg Ala Asp Thr 
385                 390                 395                 400 


Val Arg Lys Gly Thr Leu Thr Ile Gly Val Leu Gly His Lys Ile Ile 
                405                 410                 415     


Lys Glu Val Asn Glu Asp Asp Ile Ile Asn Asn Ile Arg Arg Lys Ile 
            420                 425                 430         


Val Leu Asp Lys Glu Leu Pro Tyr Ile His Ala Lys Asn Ile Ser Glu 
        435                 440                 445             


Ala Val Glu Met Arg Asp Gln Leu Met Ser Ile Asp Ile Pro Thr Phe 
    450                 455                 460                 


Ile Val Lys His Lys Asn Glu Ile Arg Leu Tyr Pro Ser Gly Pro Cys 
465                 470                 475                 480 


Ser Leu Arg Arg Leu Leu Leu Met His Gly Val Glu Glu Val Val Phe 
                485                 490                 495     


Ser Asp Glu Leu Leu Tyr Glu Ile Met Asn Cys His Leu Tyr Pro Ala 
            500                 505                 510         


Thr Trp Tyr Glu Leu Leu Tyr Ser Met Gly Leu Thr Lys Ile Ala Lys 
        515                 520                 525             


Glu Leu Asn Val Tyr Asp Phe Glu Ile Leu Ala Gly Ile Ile Lys Lys 
    530                 535                 540                 


Val Glu Lys Glu Val Ile Met Leu Ser Gln Val Leu Gly Leu Arg Asn 
545                 550                 555                 560 


Glu Thr Gln Thr Glu Leu Leu His Leu Lys Ser Arg Arg Glu Leu Leu 
                565                 570                 575     


Ile Arg Leu Lys Asp Lys Leu Asp Met Leu Arg Lys Arg Leu Lys Asp 
            580                 585                 590         


Leu Glu Glu Ala Leu Gly Lys Asp Ala Val Ile Arg Met Ile Thr Asp 
        595                 600                 605             


Val Glu Val Ile Lys Asn Thr Asp Ser Asp Trp Val Tyr Asp Ile Thr 
    610                 615                 620                 


Ile Glu Pro Tyr His Leu Phe Val Ser Asp Gly Leu Ile Leu His Asn 
625                 630                 635                 640 


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
                645                 650                 655     


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
            660                 665                 670         


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
        675                 680                 685             


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695                 700                 


<210>  419
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Sru_DnaB

<400>  419

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Gly Lys Gly Thr Pro Val Met Met Tyr Asp Gly Arg 
    290                 295                 300                 


Thr Lys Pro Val Glu Lys Val Glu Val Gly Asp Arg Leu Met Gly Asp 
305                 310                 315                 320 


Asp Gly Ser Pro Arg Thr Val Gln Ser Leu Ala Arg Gly Arg Glu Gln 
                325                 330                 335     


Met Tyr Trp Val Arg Gln Lys Arg Gly Met Asp Tyr Arg Val Asn Glu 
            340                 345                 350         


Ser His Ile Leu Ser Leu Lys Lys Ser Arg Arg Glu Gly Ala Arg Asp 
        355                 360                 365             


Arg Gly Ser Ile Ala Asp Ile Ser Val Arg Asp Tyr Leu Asp Gln Ser 
    370                 375                 380                 


Asp Lys Trp Lys Asp Asp Asn Lys Gly Phe Lys Val Ala Ala Glu Phe 
385                 390                 395                 400 


Pro Asp Gln Pro Val Pro Leu Asp Pro Tyr Phe Leu Gly Leu Trp Leu 
                405                 410                 415     


Gly Asp Gly Lys Ser Asp Asn Ala Arg Ile Tyr Thr Thr Asp Glu Glu 
            420                 425                 430         


Val Ile Thr Gly Leu Gln Glu Ile Ala Glu Lys Arg Gly Asp Thr Ile 
        435                 440                 445             


Ser Val Ser Asp Glu His Arg Arg Cys Pro Ala Tyr Leu Val Lys Ser 
    450                 455                 460                 


Gly Asp Arg Gly Gly Ala Met Ala Thr Arg Glu Ser Val Gln Gly Ala 
465                 470                 475                 480 


Leu Arg Ala Leu Gly Val Leu Gly Asp Lys His Ile Pro His Leu Tyr 
                485                 490                 495     


Leu Gly Asn Ser Arg Gly Lys Arg Leu Arg Leu Leu Ala Gly Leu Ile 
            500                 505                 510         


Asp Ser Asp Gly His Leu Asn Asp Gly His Gly Gly Thr Tyr Glu Ile 
        515                 520                 525             


Thr Gln Ser Ser Glu Gln Leu Ala Arg Asp Ile Lys Phe Leu Cys Asp 
    530                 535                 540                 


Thr Leu Gly Tyr Arg Thr Ser Leu Thr Gln Lys Thr Ala Arg Ile Ser 
545                 550                 555                 560 


Ser Thr Gly Tyr Glu Ser Glu Val His Arg Val Arg Phe Asn Gly Asn 
                565                 570                 575     


Val Asp Glu Ile Pro Val Arg Val Glu Arg Lys Lys Ala Ser Pro Trp 
            580                 585                 590         


Thr Asp Val Arg Asp Trp Arg Met Thr Gly Ile Asp Val Glu Pro Asp 
        595                 600                 605             


Gly Val Gly Asp Tyr Phe Gly Phe Thr Leu Asp Gly Asn Gly Arg Phe 
    610                 615                 620                 


Leu Leu Gly Asp Gly Thr Val Thr His Asn Ser Thr Tyr Ala Ser Leu 
625                 630                 635                 640 


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
                645                 650                 655     


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
            660                 665                 670         


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
        675                 680                 685             


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    690                 695             


<210>  420
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Sru_PolBc

<400>  420

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Asp Pro Glu Thr Glu Val Val Thr Val Asp Gly Ile 
    290                 295                 300                 


Arg His Val Glu Glu Ile Glu Val Gly Asp Arg Val Tyr Ser Leu Asn 
305                 310                 315                 320 


Pro Asp Thr Gly Ala Val Glu Ile Lys Pro Val Thr Ala Thr Gln Ser 
                325                 330                 335     


Gln His Tyr Ala Gly Pro Met Val Glu Ile Lys Asn Gln His Thr Asp 
            340                 345                 350         


Phe Leu Val Thr Pro Asn His Arg Phe Leu Thr Gln Arg Phe Thr Ser 
        355                 360                 365             


Gly Glu Tyr Thr Asp Leu Glu Trp Glu Thr Ala Gly Asp Met Leu Gly 
    370                 375                 380                 


Asp Arg Ile Arg Arg Arg Leu Pro Ser Leu Arg Ser Leu Pro Ala Thr 
385                 390                 395                 400 


Gln Glu Arg Pro Gly Pro Ile Ser Leu Ser Ala Val Cys Asp Arg Leu 
                405                 410                 415     


Ala Ile Glu His Lys Thr Gly Pro Arg Gly Ile Lys Glu Leu Arg Arg 
            420                 425                 430         


Gln Ala Arg Trp Gln Pro Glu Glu Tyr Glu Leu Thr Asp Trp Leu Arg 
        435                 440                 445             


Ile Leu Gly Trp Phe Ala Thr Glu Gly Thr Leu Tyr Lys Ser Lys Ala 
    450                 455                 460                 


Arg Gln Tyr Glu Asn Gly Asn Val Arg Gly Val Ser Tyr Gln Thr Thr 
465                 470                 475                 480 


Leu Cys Gln Lys Asn Asp Ile Gly Arg Ser Glu Ile Ala Thr Leu Leu 
                485                 490                 495     


Asn Arg Thr Gly Ile Thr Tyr Ser Ser Asp Gln Asn Asp His Ser Phe 
            500                 505                 510         


Cys Ser Lys Val Leu Tyr Glu Ile Leu Glu Ala Glu Cys Gly Ser Asp 
        515                 520                 525             


Ser Phe Ser Lys His Leu Pro Pro Trp Ile Phe Gln Leu Gly Pro Lys 
    530                 535                 540                 


Asp Leu Lys Ile Val Phe Asp Thr Leu Met Gln Gly Asp Ser Ala Ala 
545                 550                 555                 560 


Asn Gly Asp Arg Phe Thr Thr Ser Ser Asn Gln Leu Ala Glu Asp Phe 
                565                 570                 575     


Ile Arg Leu Ala Met His Ile Gly Arg Arg Ala Phe His Met Pro Asn 
            580                 585                 590         


Asp Gly Ser His Arg Ile Gln Val Asn Thr Val Arg Gly Gln Arg Pro 
        595                 600                 605             


Thr Ile Lys Pro Lys His Arg Gln Gln Val Asp Tyr Asp Gly Met Ile 
    610                 615                 620                 


His Cys Leu Thr Val Ala Asp Asn His Thr Val Leu Ala Gly Arg Asn 
625                 630                 635                 640 


Arg Lys Phe Asn Trp Thr Gly Gln Ser Thr Tyr Ala Ser Leu Asn Gly 
                645                 650                 655     


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            660                 665                 670         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        675                 680                 685             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    690                 695                 700                 


Val Asn Ala Glu Ala Ala Thr Arg 
705                 710         


<210>  421
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ssp_DnaB

<400>  421

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Ile Ser Gly Asp Ser Leu Ile Ser Leu Ala Ser Thr Gly 
    290                 295                 300                 


Lys Arg Val Ser Ile Lys Asp Leu Leu Asp Glu Lys Asp Phe Glu Ile 
305                 310                 315                 320 


Trp Ala Ile Asn Glu Gln Thr Met Lys Leu Glu Ser Ala Lys Val Ser 
                325                 330                 335     


Arg Val Phe Cys Thr Gly Lys Lys Leu Val Tyr Ile Leu Lys Thr Arg 
            340                 345                 350         


Leu Gly Arg Thr Ile Lys Ala Thr Ala Asn His Arg Phe Leu Thr Ile 
        355                 360                 365             


Asp Gly Trp Lys Arg Leu Asp Glu Leu Ser Leu Lys Glu His Ile Ala 
    370                 375                 380                 


Leu Pro Arg Lys Leu Glu Ser Ser Ser Leu Gln Leu Met Ser Asp Glu 
385                 390                 395                 400 


Glu Leu Gly Leu Leu Gly His Leu Ile Gly Asp Gly Cys Thr Leu Pro 
                405                 410                 415     


Arg His Ala Ile Gln Tyr Thr Ser Asn Lys Ile Glu Leu Ala Glu Lys 
            420                 425                 430         


Val Val Glu Leu Ala Lys Ala Val Phe Gly Asp Gln Ile Asn Pro Arg 
        435                 440                 445             


Ile Ser Gln Glu Arg Gln Trp Tyr Gln Val Tyr Ile Pro Ala Ser Tyr 
    450                 455                 460                 


Arg Leu Thr His Asn Lys Lys Asn Pro Ile Thr Lys Trp Leu Glu Asn 
465                 470                 475                 480 


Leu Asp Val Phe Gly Leu Arg Ser Tyr Glu Lys Phe Val Pro Asn Gln 
                485                 490                 495     


Val Phe Glu Gln Pro Gln Arg Ala Ile Ala Ile Phe Leu Arg His Leu 
            500                 505                 510         


Trp Ser Thr Asp Gly Cys Val Lys Leu Ile Val Glu Lys Ser Ser Arg 
        515                 520                 525             


Pro Val Ala Tyr Tyr Ala Thr Ser Ser Glu Lys Leu Ala Lys Asp Val 
    530                 535                 540                 


Gln Ser Leu Leu Leu Lys Leu Gly Ile Asn Ala Arg Leu Ser Lys Ile 
545                 550                 555                 560 


Ser Gln Asn Gly Lys Gly Arg Asp Asn Tyr His Val Thr Ile Thr Gly 
                565                 570                 575     


Gln Ala Asp Leu Gln Ile Phe Val Asp Gln Ile Gly Ala Val Asp Lys 
            580                 585                 590         


Asp Lys Gln Ala Ser Val Glu Glu Ile Lys Thr His Ile Ala Gln His 
        595                 600                 605             


Gln Ala Asn Thr Asn Arg Asp Val Ile Pro Lys Gln Ile Trp Lys Thr 
    610                 615                 620                 


Tyr Val Leu Pro Gln Ile Gln Ile Lys Gly Ile Thr Thr Arg Asp Leu 
625                 630                 635                 640 


Gln Met Arg Leu Gly Asn Ala Tyr Cys Gly Thr Ala Leu Tyr Lys His 
                645                 650                 655     


Asn Leu Ser Arg Glu Arg Ala Ala Lys Ile Ala Thr Ile Thr Gln Ser 
            660                 665                 670         


Pro Glu Ile Glu Lys Leu Ser Gln Ser Asp Ile Tyr Trp Asp Ser Ile 
        675                 680                 685             


Val Ser Ile Thr Glu Thr Gly Val Glu Glu Val Phe Asp Leu Thr Val 
    690                 695                 700                 


Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile Val His Asn Ser 
705                 710                 715                 720 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
                725                 730                 735     


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
            740                 745                 750         


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
        755                 760                 765             


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780             


<210>  422
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ssp_GyrB

<400>  422

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ser Gly Asp Thr Leu Val Ala Leu Thr Asp Gly Arg 
    290                 295                 300                 


Ser Val Ser Phe Glu Gln Leu Val Glu Glu Glu Lys Gln Gly Lys Gln 
305                 310                 315                 320 


Asn Phe Cys Tyr Thr Ile Arg His Asp Gly Ser Ile Gly Val Glu Lys 
                325                 330                 335     


Ile Ile Asn Ala Arg Lys Thr Lys Thr Asn Ala Lys Val Ile Lys Val 
            340                 345                 350         


Thr Leu Asp Asn Gly Glu Ser Ile Ile Cys Thr Pro Asp His Lys Phe 
        355                 360                 365             


Met Leu Arg Asp Gly Ser Tyr Lys Cys Ala Met Asp Leu Thr Leu Asp 
    370                 375                 380                 


Asp Ser Leu Met Pro Leu His Arg Lys Ile Ser Thr Thr Glu Asp Ser 
385                 390                 395                 400 


Gly Ile Thr Ile Asp Gly Tyr Glu Met Val Trp Ser Pro Arg Ser Asp 
                405                 410                 415     


Ser Trp Leu Phe Thr His Leu Val Ala Asp Trp Tyr Asn Arg Trp Gln 
            420                 425                 430         


Gly Ile Tyr Ile Ala Glu Glu Lys Gln His Cys His His Lys Asp Phe 
        435                 440                 445             


Asn Lys Arg Asn Asn Asn Pro Asp Asn Leu Ile Arg Leu Ser Pro Glu 
    450                 455                 460                 


Lys His Leu Ala Leu His Arg Lys His Ile Ser Lys Thr Leu His Arg 
465                 470                 475                 480 


Pro Asp Val Val Glu Lys Cys Arg Arg Ile His Gln Ser Pro Glu Phe 
                485                 490                 495     


Arg Arg Lys Met Ser Ala Arg Met Gln Ser Pro Glu Thr Arg Ala Ile 
            500                 505                 510         


Leu Ser Lys Gln Ala Gln Ala Gln Trp Gln Asn Glu Thr Tyr Lys Leu 
        515                 520                 525             


Thr Met Met Glu Ser Trp Arg Ser Phe Tyr Asp Ser Asn Glu Asp Tyr 
    530                 535                 540                 


Arg Gln Gln Asn Ala Glu Gln Leu Asn Arg Ala Gln Gln Glu Tyr Trp 
545                 550                 555                 560 


Ala Gln Ala Glu Asn Arg Thr Ala Gln Ala Glu Arg Val Arg Gln His 
                565                 570                 575     


Phe Ala Gln Asn Pro Gly Leu Arg Gln Gln Tyr Ser Glu Asn Ala Val 
            580                 585                 590         


Lys Gln Trp Asn Asn Pro Glu Leu Leu Lys Trp Arg Gln Lys Lys Thr 
        595                 600                 605             


Lys Glu Gln Trp Thr Pro Glu Phe Arg Glu Lys Arg Arg Glu Ala Leu 
    610                 615                 620                 


Ala Gln Thr Tyr Tyr Arg Lys Thr Leu Ala Ala Leu Lys Gln Val Glu 
625                 630                 635                 640 


Ile Glu Asn Gly Tyr Leu Asp Ile Ser Ala Tyr Asp Ser Tyr Arg Ile 
                645                 650                 655     


Ser Thr Lys Asp Lys Ser Leu Leu Arg Phe Asp Arg Phe Cys Glu Arg 
            660                 665                 670         


Tyr Phe Glu Asn Asp Glu Asn Leu Ala Arg Glu Ala Val Leu Asn Tyr 
        675                 680                 685             


Asn His Arg Ile Val Asn Ile Glu Ala Val Ser Glu Thr Ile Asp Val 
    690                 695                 700                 


Tyr Asp Ile Glu Val Pro His Thr His Asn Phe Ala Leu Ala Ser Gly 
705                 710                 715                 720 


Val Phe Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
                725                 730                 735     


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
            740                 745                 750         


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
        755                 760                 765             


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
    770                 775                 780                 


Glu Ala Ala Thr Arg 
785                 


<210>  423
<211>  774
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:StP-Twort_ORF6

<400>  423

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Ile Ser Met Asp Ser Met Ile Leu Thr Thr Glu Gly Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Glu Ile Phe Glu Thr Gln Gly Val Lys Val Asp Asn 
305                 310                 315                 320 


Lys Glu Lys Val Ile Glu Leu Lys Tyr Pro Leu Ile Asn Arg Tyr Gly 
                325                 330                 335     


Asp Val Glu Tyr Thr Ser His Phe Thr Lys Asn Gly Glu Lys Pro Thr 
            340                 345                 350         


Lys Arg Ile Lys Thr Asn Lys Gly Ile Glu Leu Val Asn Thr Tyr Asn 
        355                 360                 365             


His Pro Leu Leu Val Arg Glu Gly Phe Asn Leu Ile Trp Lys Lys Ser 
    370                 375                 380                 


Glu Asp Ile Glu Val Gly Asp Ile Leu Val Ser Arg Val Gly Asp His 
385                 390                 395                 400 


Gln Phe Gly Asn Asn Asn Thr Val Glu Asn Glu Glu Glu Ala Tyr Ala 
                405                 410                 415     


Leu Gly Cys Met Val Ala Asp Ser Tyr Leu Gly Ser Tyr Ser Arg Leu 
            420                 425                 430         


Ser Phe Ser Asn Asp Lys Lys Glu Ile Leu Asp Lys Val Ser Lys Phe 
        435                 440                 445             


Trp Asn Thr Phe Ser Asn Lys Glu Val Tyr Tyr Asp Thr Tyr Lys Glu 
    450                 455                 460                 


Ser Lys Gly Ile Thr Ile His Leu His Asp Thr Asn Lys Thr Lys Glu 
465                 470                 475                 480 


Phe His Asp Lys Tyr Lys Ile Glu Tyr Gly Val Ala Lys Asp Lys Lys 
                485                 490                 495     


Ile Pro Lys Cys Ile Met Glu Ser Pro Glu Asn Ile Gln Leu Ala Phe 
            500                 505                 510         


Val Ser Gly Tyr Leu Glu Cys Glu Ser Ser Ile Ser Glu Lys Asn Leu 
        515                 520                 525             


Glu Val Thr Ser Ala Ser Lys Asp Leu Leu Lys Asp Leu Gln Leu Ile 
    530                 535                 540                 


Leu Ser Asn Ile Gly Ile Val Ser Thr Asn Lys Glu Lys Val Val Lys 
545                 550                 555                 560 


Lys Tyr Lys His Asn Lys Tyr Tyr Arg Leu Ile Val Asn Arg Lys Glu 
                565                 570                 575     


Leu Ile Lys Leu Leu Pro Leu Leu Arg Phe Glu Thr Gln Gln Arg Lys 
            580                 585                 590         


Asn Gln Lys Glu Asn Phe Leu Ser Asn Asn Thr Lys Ile Lys Ser Ser 
        595                 600                 605             


Tyr Gly Asn Thr Ile Glu Gly Ser Arg Tyr Leu Leu Lys Lys Tyr Arg 
    610                 615                 620                 


Asp Ser Leu Asn Ile Asp Lys Lys Glu Phe Ser Lys Tyr Leu Ser Arg 
625                 630                 635                 640 


Asp Thr Ile Thr Ile Asp Arg Leu Arg Glu Val Ile Ser Leu Tyr Pro 
                645                 650                 655     


Asp Gly Asp Lys Glu Ile Arg Glu Leu Phe Glu Asn Val Val Asn Asn 
            660                 665                 670         


Asn Ile Tyr Tyr Gln Lys Val Glu Gln Val Leu Glu Gly Glu Ile Ile 
        675                 680                 685             


Pro Thr Phe Asp Val Cys Met Pro Lys Thr His Ser Phe Ile Ala Asn 
    690                 695                 700                 


Thr Ile Val Asn His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser 
705                 710                 715                 720 


Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys 
                725                 730                 735     


Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr 
            740                 745                 750         


Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn 
        755                 760                 765             


Ala Glu Ala Ala Thr Arg 
    770                 


<210>  424
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Tag_Pol-1_Tsp-TY_Pol-1

<400>  424

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys His Pro Ala Asp Thr Lys Val Ile Val Lys Gly Lys Gly 
    290                 295                 300                 


Ile Val Asn Ile Ser Asp Val Lys Glu Gly Asp Tyr Ile Leu Gly Ile 
305                 310                 315                 320 


Asp Gly Trp Gln Arg Val Lys Lys Val Trp Lys Tyr His Tyr Glu Gly 
                325                 330                 335     


Lys Leu Ile Asn Ile Asn Gly Leu Lys Cys Thr Pro Asn His Lys Val 
            340                 345                 350         


Pro Val Val Thr Glu Asn Asp Arg Gln Thr Arg Ile Arg Asp Ser Leu 
        355                 360                 365             


Ala Lys Ser Phe Leu Ser Gly Lys Val Lys Gly Lys Ile Ile Thr Thr 
    370                 375                 380                 


Lys Leu Phe Glu Lys Ile Ala Glu Phe Glu Lys Asn Lys Pro Ser Glu 
385                 390                 395                 400 


Glu Glu Ile Leu Lys Gly Glu Leu Ser Gly Ile Ile Leu Ala Glu Gly 
                405                 410                 415     


Thr Leu Leu Arg Lys Asp Ile Glu Tyr Phe Asp Ser Ser Arg Gly Lys 
            420                 425                 430         


Lys Arg Ile Ser His Gln Tyr Arg Val Glu Ile Thr Ile Gly Glu Asn 
        435                 440                 445             


Glu Lys Glu Leu Leu Glu Arg Ile Leu Tyr Ile Phe Asp Lys Leu Phe 
    450                 455                 460                 


Gly Ile Arg Pro Ser Val Lys Lys Lys Gly Asp Thr Asn Ala Leu Lys 
465                 470                 475                 480 


Ile Thr Thr Ala Lys Lys Ala Val Tyr Leu Gln Ile Glu Glu Leu Leu 
                485                 490                 495     


Lys Asn Ile Glu Ser Leu Tyr Ala Pro Ala Val Leu Arg Gly Phe Phe 
            500                 505                 510         


Glu Arg Asp Ala Thr Val Asn Lys Ile Arg Ser Thr Ile Val Val Thr 
        515                 520                 525             


Gln Gly Thr Asn Asn Lys Trp Lys Ile Asp Ile Val Ala Lys Leu Leu 
    530                 535                 540                 


Asp Ser Leu Gly Ile Pro Tyr Ser Arg Tyr Glu Tyr Lys Tyr Ile Glu 
545                 550                 555                 560 


Asn Gly Lys Glu Leu Thr Lys His Ile Leu Glu Ile Thr Gly Arg Asp 
                565                 570                 575     


Gly Leu Ile Leu Phe Gln Thr Leu Val Gly Phe Ile Ser Ser Glu Lys 
            580                 585                 590         


Asn Glu Ala Leu Glu Lys Ala Ile Glu Val Arg Glu Met Asn Arg Leu 
        595                 600                 605             


Lys Asn Asn Ser Phe Tyr Asn Leu Ser Thr Phe Glu Val Ser Ser Glu 
    610                 615                 620                 


Tyr Tyr Lys Gly Glu Val Tyr Asp Leu Thr Leu Glu Gly Asn Pro Tyr 
625                 630                 635                 640 


Tyr Phe Ala Asn Gly Ile Leu Thr His Asn Ser Thr Tyr Ala Ser Leu 
                645                 650                 655     


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
            660                 665                 670         


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
        675                 680                 685             


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
    690                 695                 700                 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
705                 710                 


<210>  425
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Tag_Pol-2_Tsp-TY_Pol-2_T134

<400>  425

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Ile Leu Pro Asn Glu Trp Leu Pro Ile Ile Glu Asn Gly 
    290                 295                 300                 


Glu Val Lys Phe Val Lys Ile Gly Glu Phe Ile Asp Arg Tyr Met Glu 
305                 310                 315                 320 


Glu Gln Lys Asp Lys Val Arg Thr Val Asp Asn Thr Glu Val Leu Glu 
                325                 330                 335     


Val Asp Asn Ile Phe Ala Phe Ser Leu Asn Lys Glu Ser Lys Lys Ser 
            340                 345                 350         


Glu Ile Lys Lys Val Lys Ala Leu Ile Arg His Lys Tyr Lys Gly Glu 
        355                 360                 365             


Ala Tyr Glu Val Glu Leu Asn Ser Gly Arg Lys Ile His Ile Thr Arg 
    370                 375                 380                 


Gly His Ser Leu Phe Thr Ile Arg Asn Gly Lys Ile Lys Glu Ile Trp 
385                 390                 395                 400 


Gly Glu Glu Val Lys Val Gly Asp Leu Ile Ile Val Pro Lys Lys Val 
                405                 410                 415     


Lys Leu Asn Glu Lys Glu Ala Val Ile Asn Ile Pro Glu Leu Ile Ser 
            420                 425                 430         


Lys Leu Pro Asp Glu Asp Thr Ala Asp Val Val Met Thr Thr Pro Val 
        435                 440                 445             


Lys Gly Arg Lys Asn Phe Phe Lys Gly Met Leu Arg Thr Leu Lys Trp 
    450                 455                 460                 


Ile Phe Gly Glu Glu Ser Lys Arg Ile Arg Thr Phe Asn Arg Tyr Leu 
465                 470                 475                 480 


Phe His Leu Glu Glu Leu Gly Phe Val Lys Leu Leu Pro Arg Gly Tyr 
                485                 490                 495     


Glu Val Thr Asp Trp Glu Gly Leu Lys Arg Tyr Arg Gln Leu Tyr Glu 
            500                 505                 510         


Lys Leu Val Lys Asn Leu Arg Tyr Asn Gly Asn Lys Arg Glu Tyr Leu 
        515                 520                 525             


Val Arg Phe Asn Asp Ile Lys Asp Ser Val Ser Cys Phe Pro Arg Lys 
    530                 535                 540                 


Glu Leu Glu Glu Trp Lys Ile Gly Thr Arg Lys Gly Phe Arg Arg Lys 
545                 550                 555                 560 


Cys Ile Leu Lys Val Asp Glu Asp Phe Gly Lys Phe Leu Gly Tyr Tyr 
                565                 570                 575     


Val Ser Glu Gly Tyr Ala Gly Ala Gln Lys Asn Lys Thr Gly Gly Met 
            580                 585                 590         


Ser Tyr Ser Val Lys Leu Tyr Asn Glu Asn Pro Asn Val Leu Lys Asp 
        595                 600                 605             


Met Lys Asn Ile Ala Glu Lys Phe Phe Gly Lys Val Arg Val Gly Lys 
    610                 615                 620                 


Asn Cys Val Asp Ile Pro Lys Lys Met Ala Tyr Leu Leu Ala Lys Ser 
625                 630                 635                 640 


Leu Cys Gly Val Thr Ala Glu Asn Lys Arg Ile Pro Ser Ile Ile Phe 
                645                 650                 655     


Asp Ser Ser Glu Pro Val Arg Trp Ala Phe Leu Arg Ala Tyr Phe Val 
            660                 665                 670         


Gly Asp Gly Asp Ile His Pro Ser Lys Arg Leu Arg Leu Ser Thr Lys 
        675                 680                 685             


Ser Glu Leu Leu Ala Asn Gln Leu Val Phe Leu Leu Asn Ser Leu Gly 
    690                 695                 700                 


Val Ser Ser Ile Lys Ile Gly Phe Asp Ser Gly Val Tyr Arg Val Tyr 
705                 710                 715                 720 


Ile Asn Glu Asp Leu Pro Phe Leu Gln Thr Ser Arg Gln Lys Asn Thr 
                725                 730                 735     


Tyr Tyr Pro Asn Leu Ile Pro Lys Glu Val Leu Glu Glu Ile Phe Gly 
            740                 745                 750         


Arg Lys Phe Gln Lys Asn Ile Thr Phe Glu Lys Phe Lys Glu Leu Ala 
        755                 760                 765             


Asp Ser Gly Lys Leu Asp Lys Arg Lys Val Lys Leu Leu Asp Phe Leu 
    770                 775                 780                 


Leu Asn Gly Asp Ile Val Leu Asp Arg Val Lys Asn Val Glu Lys Arg 
785                 790                 795                 800 


Glu Tyr Glu Gly Tyr Val Tyr Asp Leu Ser Val Glu Asp Asn Glu Asn 
                805                 810                 815     


Phe Leu Val Gly Phe Gly Leu Leu Tyr Ala His Asn Ser Thr Tyr Ala 
            820                 825                 830         


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
        835                 840                 845             


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
    850                 855                 860                 


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
865                 870                 875                 880 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                885                 890         


<210>  426
<211>  2340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ter_DnaB-1

<400>  426

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Ala Ala Tyr Asp Thr Leu Val Leu Gln Lys Asp Gly Ser 
    290                 295                 300                 


Leu Val Thr Leu Ala Glu Val Tyr Lys Arg Gln Glu Ile Glu Leu Leu 
305                 310                 315                 320 


Thr Leu Gly Lys Asn Ser Lys Phe Tyr Leu Thr Lys Pro Ser Ala Phe 
                325                 330                 335     


Ile Asp Asp Gly Ile Lys Pro Ile Phe Arg Val Thr Thr Lys Leu Gly 
            340                 345                 350         


Arg Phe Val Glu Thr Thr Ile Thr His Pro Phe Leu Thr Val Asn Gly 
        355                 360                 365             


Trp Lys Pro Leu Ser Lys Leu Gln Val Gly Glu Lys Ile Ala Val Pro 
    370                 375                 380                 


Arg Arg Leu Asn Ile Phe Gly Asn Glu Thr Ile Ser Glu Ser Lys Phe 
385                 390                 395                 400 


Ser Ser Leu Ile Asn Phe Asp Asn Leu Tyr Leu Phe Pro Leu Val Phe 
                405                 410                 415     


Gln Leu Glu Arg Ser Gln Leu Ala Leu Phe Ile Arg Tyr Leu Phe Ser 
            420                 425                 430         


Leu Asp Gly Trp Val Lys Ile Tyr Gln Asn Lys Ile Val Cys Phe Gly 
        435                 440                 445             


Tyr Ser Thr Val Ser Glu Lys Leu Ile Arg Gln Ile Gln His Ile Leu 
    450                 455                 460                 


Leu Arg Phe Gly Ile Val Ser Gly Ile Glu Lys Phe Glu Glu Lys Arg 
465                 470                 475                 480 


Thr Glu Lys Ile Lys Val Val Lys Glu Val Lys Ser Gln Arg Ser His 
                485                 490                 495     


Arg Glu Glu Phe Thr Phe Ala Thr Tyr Arg Asn Cys Tyr Cys Asp Gly 
            500                 505                 510         


Lys Trp His Leu Thr Ile Thr Asp Ala Leu Ser Gln Lys Asn Leu Met 
        515                 520                 525             


Glu Asp Ile Gly Gly Phe Asp Ser Lys Asn Phe Tyr Leu Phe Asp Leu 
    530                 535                 540                 


Leu Gln Pro His Asn Ser Gly Asn Gln Glu Leu Glu Asn His Leu Ile 
545                 550                 555                 560 


Phe Trp Asp Glu Leu Val Asn Val Leu Ala Lys Phe Ala Ala Ser Lys 
                565                 570                 575     


Asn Gln Ser Leu Lys Asn Arg Thr Ala Lys Gly Lys Ser Pro Lys Asn 
            580                 585                 590         


Ser Glu Asn Leu Thr Thr Thr Glu Thr Ile Cys Arg Lys Asn Ile Leu 
        595                 600                 605             


Ala Asn Met Glu Asn Leu Pro Ser Asp Asn Gln Asn Phe Asp Ser Glu 
    610                 615                 620                 


Lys Leu Asp Leu Ser Gln Pro His Asn Ser Gly Asn Gln Glu Leu Glu 
625                 630                 635                 640 


Asn His Leu Ile Phe Trp Asp Glu Leu Val Asn Val Leu Ala Lys Phe 
                645                 650                 655     


Ala Thr Ser Lys Asn Gln Ser Leu Lys Asn Arg Thr Thr Lys Arg Asn 
            660                 665                 670         


Ser Pro Lys Asn Ser Glu Asn Leu Thr Thr Thr Glu Thr Ile Cys Arg 
        675                 680                 685             


Lys Asn Ile Leu Ala Asn Met Glu Asn Leu Pro Ser Asp Asn Gln Asn 
    690                 695                 700                 


Phe Asp Ser Glu Lys Leu Asp Leu Pro Gln Pro His Asn Ser Gly Asn 
705                 710                 715                 720 


Gln Glu Leu Glu Asn His Leu Ile Phe Trp Asp Glu Leu Val Asn Val 
                725                 730                 735     


Leu Ala Lys Phe Ala Ala Ser Lys Asn Gln Ser Leu Lys Asn Arg Thr 
            740                 745                 750         


Thr Lys Arg Asn Ser Pro Lys Asn Ser Glu Asn Leu Thr Thr Thr Glu 
        755                 760                 765             


Thr Ile Cys Arg Lys Asn Ile Leu Ala Asn Met Glu Asn Leu Pro Ser 
    770                 775                 780                 


Asp Asn Gln Asn Phe Asp Ser Glu Lys Leu Asp Leu Pro Gln Pro His 
785                 790                 795                 800 


Asn Ser Gly Asn Gln Glu Leu Glu Asn His Leu Ile Phe Trp Asp Glu 
                805                 810                 815     


Leu Val Asn Val Leu Ala Lys Phe Ala Thr Ser Lys Asn Gln Ser Leu 
            820                 825                 830         


Lys Asn Arg Thr Thr Lys Arg Asn Ser Pro Lys Asn Ser Glu Asn Leu 
        835                 840                 845             


Thr Thr Thr Glu Thr Ile Cys Arg Lys Asn Ile Leu Ala Asn Met Glu 
    850                 855                 860                 


Asn Leu Pro Ser Asp Asn Gln Asn Phe Asp Ser Glu Lys Leu Asp Leu 
865                 870                 875                 880 


Ser Gln Pro His Asn Ser Gly Thr Gln Glu Leu Glu Asn His Leu Ile 
                885                 890                 895     


Phe Trp Asp Glu Leu Val Asn Val Leu Ala Lys Phe Ala Ala Ser Lys 
            900                 905                 910         


Asn Gln Ser Leu Lys Asn Arg Thr Ala Lys Gly Lys Ser Pro Lys Asn 
        915                 920                 925             


Ser Glu Asn Leu Thr Thr Thr Glu Thr Ile Cys Arg Lys Asn Ile Leu 
    930                 935                 940                 


Ala Asn Met Glu Asn Leu Pro Ser Asp Asn Gln Asn Phe Asp Ser Glu 
945                 950                 955                 960 


Lys Leu Asp Leu Ser Gln Pro His Asn Ser Gly Asn Gln Glu Leu Glu 
                965                 970                 975     


Asn His Leu Ile Phe Trp Asp Glu Leu Val Asn Val Leu Ala Lys Phe 
            980                 985                 990         


Ala Thr Ser Lys Asn Gln Ser Leu  Lys Asn Arg Thr Thr  Lys Arg Asn 
        995                 1000                 1005             


Ser Pro  Lys Asn Ser Glu Asn  Leu Thr Thr Thr Glu  Thr Ile Cys 
    1010                 1015                 1020             


Arg Lys  Asn Ile Leu Ala Asn  Met Glu Asn Leu Pro  Ser Asp Asn 
    1025                 1030                 1035             


Gln Asn  Phe Asp Ser Glu Lys  Leu Asp Leu Pro Gln  Pro His Asn 
    1040                 1045                 1050             


Ser Gly  Asn Gln Glu Leu Glu  Asn His Leu Ile Phe  Trp Asp Glu 
    1055                 1060                 1065             


Leu Val  Asn Val Leu Ala Lys  Phe Ala Thr Ser Lys  Asn Gln Ser 
    1070                 1075                 1080             


Leu Lys  Asn Arg Thr Thr Lys  Arg Asn Ser Pro Lys  Asn Ser Glu 
    1085                 1090                 1095             


Asn Leu  Thr Thr Thr Glu Thr  Ile Cys Arg Lys Asn  Ile Leu Ala 
    1100                 1105                 1110             


Asn Met  Glu Asn Leu Pro Ser  Asp Asn Gln Asn Phe  Asp Ser Glu 
    1115                 1120                 1125             


Lys Leu  Asp Leu Pro Gln Pro  His Asn Ser Gly Asn  Gln Glu Leu 
    1130                 1135                 1140             


Glu Asn  His Leu Ile Phe Trp  Asp Glu Leu Val Asn  Val Leu Ala 
    1145                 1150                 1155             


Lys Phe  Ala Thr Ser Lys Asn  Gln Ser Leu Lys Asn  Arg Thr Thr 
    1160                 1165                 1170             


Lys Arg  Asn Ser Pro Lys Asn  Ser Glu Asn Leu Thr  Thr Thr Glu 
    1175                 1180                 1185             


Thr Ile  Cys Arg Lys Asn Ile  Leu Ala Asn Met Glu  Asn Leu Pro 
    1190                 1195                 1200             


Ser Asp  Asn Gln Asn Phe Asp  Ser Glu Lys Leu Asp  Leu Pro Gln 
    1205                 1210                 1215             


Pro His  Asn Ser Gly Asn Gln  Glu Leu Glu Asn His  Leu Ile Phe 
    1220                 1225                 1230             


Trp Asp  Glu Leu Val Asn Val  Leu Ala Lys Phe Ala  Thr Ser Lys 
    1235                 1240                 1245             


Asn Gln  Ser Leu Lys Asn Arg  Thr Thr Lys Arg Asn  Ser Pro Lys 
    1250                 1255                 1260             


Asn Ser  Glu Asn Leu Thr Thr  Thr Glu Thr Ile Cys  Arg Lys Asn 
    1265                 1270                 1275             


Ile Leu  Ala Asn Met Glu Asn  Leu Pro Ser Asp Asn  Gln Asn Phe 
    1280                 1285                 1290             


Asp Ser  Glu Lys Leu Asp Leu  Pro Gln Pro His Asn  Ser Gly Asn 
    1295                 1300                 1305             


Gln Glu  Leu Glu Asn His Leu  Ile Phe Trp Asp Glu  Leu Val Asn 
    1310                 1315                 1320             


Val Leu  Ala Lys Phe Ala Thr  Ser Lys Asn Gln Ser  Leu Lys Asn 
    1325                 1330                 1335             


Arg Thr  Thr Lys Arg Asn Ser  Pro Lys Asn Ser Glu  Asn Leu Thr 
    1340                 1345                 1350             


Thr Thr  Glu Thr Ile Cys Arg  Lys Asn Ile Leu Ala  Asn Met Glu 
    1355                 1360                 1365             


Asn Leu  Pro Ser Asp Asn Gln  Asn Phe Asp Ser Glu  Lys Leu Asp 
    1370                 1375                 1380             


Leu Ser  Gln Pro His Asn Ser  Gly Thr Gln Glu Leu  Glu Asn His 
    1385                 1390                 1395             


Leu Ile  Phe Trp Asp Glu Leu  Val Asn Val Leu Ala  Lys Phe Ala 
    1400                 1405                 1410             


Ala Ser  Lys Asn Gln Ser Leu  Lys Asn Arg Thr Thr  Lys Arg Asn 
    1415                 1420                 1425             


Ser Pro  Lys Asn Ser Glu Asn  Leu Thr Thr Thr Glu  Thr Ile Cys 
    1430                 1435                 1440             


Arg Lys  Asn Ile Leu Ala Asn  Met Glu Asn Leu Pro  Ser Asp Asn 
    1445                 1450                 1455             


Gln Asn  Phe Asp Ser Glu Lys  Leu Asp Leu Pro Gln  Pro His Asn 
    1460                 1465                 1470             


Ser Gly  Thr Gln Glu Leu Glu  Asn His Leu Ile Phe  Trp Asp Glu 
    1475                 1480                 1485             


Leu Val  Asn Val Leu Ala Lys  Phe Ala Ala Ser Lys  Asn Gln Ser 
    1490                 1495                 1500             


Leu Lys  Asn Arg Thr Thr Lys  Arg Asn Ser Pro Lys  Asn Ser Glu 
    1505                 1510                 1515             


Asn Leu  Thr Thr Thr Glu Thr  Ile Cys Arg Lys Asn  Ile Leu Ala 
    1520                 1525                 1530             


Asn Met  Glu Asn Leu Pro Ser  Asp Asn Gln Asn Phe  Asp Ser Glu 
    1535                 1540                 1545             


Lys Leu  Asp Leu Pro Gln Pro  His Asn Ser Gly Asn  Gln Glu Leu 
    1550                 1555                 1560             


Glu Asn  His Leu Ile Phe Trp  Asp Glu Leu Val Asn  Val Leu Ala 
    1565                 1570                 1575             


Lys Phe  Ala Ala Ser Lys Asn  Gln Ser Leu Lys Asn  Arg Thr Thr 
    1580                 1585                 1590             


Lys Arg  Asn Ser Pro Lys Asn  Ser Glu Asn Leu Thr  Thr Thr Glu 
    1595                 1600                 1605             


Thr Ile  Cys Arg Lys Asn Ile  Leu Ala Asn Met Glu  Asn Leu Pro 
    1610                 1615                 1620             


Ser Asp  Asn Gln Asn Phe Asp  Ser Glu Lys Leu Asp  Leu Pro Gln 
    1625                 1630                 1635             


Pro His  Asn Ser Gly Asn Gln  Glu Leu Glu Asn His  Leu Ile Phe 
    1640                 1645                 1650             


Trp Asp  Glu Leu Val Asn Val  Leu Ala Lys Phe Ala  Thr Ser Lys 
    1655                 1660                 1665             


Asn Gln  Ser Leu Lys Asn Arg  Thr Thr Lys Arg Asn  Ser Pro Lys 
    1670                 1675                 1680             


Asn Ser  Glu Asn Leu Thr Thr  Thr Glu Thr Ile Cys  Arg Lys Asn 
    1685                 1690                 1695             


Ile Leu  Ala Asn Met Glu Asn  Leu Pro Ser Asp Asn  Gln Asn Phe 
    1700                 1705                 1710             


Asp Ser  Glu Lys Leu Asp Leu  Pro Gln Pro His Asn  Ser Gly Asn 
    1715                 1720                 1725             


Gln Glu  Leu Glu Asn His Leu  Ile Phe Trp Asp Glu  Leu Val Asn 
    1730                 1735                 1740             


Val Leu  Ala Lys Phe Ala Thr  Ser Lys Asn Gln Ser  Leu Lys Asn 
    1745                 1750                 1755             


Arg Thr  Ala Lys Gly Lys Ser  Pro Lys Asn Ser Glu  Asn Leu Thr 
    1760                 1765                 1770             


Thr Thr  Glu Thr Ile Cys Arg  Lys Asn Ile Leu Ala  Asn Met Glu 
    1775                 1780                 1785             


Asn Leu  Pro Ser Asp Asn Gln  Asn Phe Asp Ser Glu  Lys Leu Asp 
    1790                 1795                 1800             


Leu Pro  Gln Pro His Asn Ser  Gly Asn Gln Glu Leu  Glu Asn His 
    1805                 1810                 1815             


Leu Ile  Phe Trp Asp Glu Leu  Val Asn Val Leu Ala  Lys Phe Ala 
    1820                 1825                 1830             


Thr Ser  Lys Asn Gln Ser Leu  Lys Asn Arg Thr Thr  Lys Arg Asn 
    1835                 1840                 1845             


Ser Pro  Lys Asn Ser Glu Asn  Leu Thr Thr Thr Glu  Thr Ile Cys 
    1850                 1855                 1860             


Arg Lys  Asn Ile Leu Ala Asn  Met Glu Asn Leu Pro  Ser Asp Asn 
    1865                 1870                 1875             


Gln Asn  Phe Asp Ser Glu Lys  Leu Asp Leu Pro Gln  Pro His Asn 
    1880                 1885                 1890             


Ser Gly  Asn Gln Glu Leu Glu  Asn His Leu Ile Phe  Trp Asp Glu 
    1895                 1900                 1905             


Leu Val  Asn Val Leu Ala Lys  Phe Ala Thr Ser Lys  Asn Gln Ser 
    1910                 1915                 1920             


Leu Lys  Asn Arg Thr Thr Lys  Arg Asn Ser Pro Lys  Asn Ser Glu 
    1925                 1930                 1935             


Asn Leu  Thr Thr Thr Glu Thr  Ile Cys Arg Lys Asn  Ile Leu Ala 
    1940                 1945                 1950             


Asn Met  Glu Asn Leu Pro Ser  Asp Asn Gln Asn Phe  Asp Ser Glu 
    1955                 1960                 1965             


Lys Leu  Asp Leu Pro Gln Pro  His Asn Ser Gly Asn  Gln Glu Leu 
    1970                 1975                 1980             


Glu Asn  His Leu Ile Phe Trp  Asp Glu Leu Val Asn  Val Leu Ala 
    1985                 1990                 1995             


Lys Phe  Ala Thr Ser Lys Asn  Gln Ser Leu Lys Asn  Arg Thr Ala 
    2000                 2005                 2010             


Lys Gly  Lys Ser Pro Lys Asn  Ser Glu Asn Leu Thr  Thr Thr Glu 
    2015                 2020                 2025             


Thr Ile  Cys Arg Lys Asn Ile  Leu Ala Asn Met Glu  Asn Leu Pro 
    2030                 2035                 2040             


Ser Asp  Asn Gln Asn Phe Asp  Ser Glu Lys Leu Asp  Leu Pro Gln 
    2045                 2050                 2055             


Pro His  Asn Ser Gly Asn Gln  Glu Leu Glu Asn His  Leu Ile Phe 
    2060                 2065                 2070             


Trp Asp  Glu Leu Val Asn Val  Leu Ala Lys Phe Ala  Thr Ser Lys 
    2075                 2080                 2085             


Asn Gln  Ser Leu Lys Asn Arg  Thr Thr Lys Arg Asn  Ser Pro Lys 
    2090                 2095                 2100             


Asn Ser  Glu Asn Leu Thr Thr  Thr Glu Thr Ile Cys  Arg Lys Asn 
    2105                 2110                 2115             


Ile Leu  Ala Asn Met Glu Asn  Leu Pro Ser Asp Asn  Gln Asn Phe 
    2120                 2125                 2130             


Asp Ser  Glu Lys Leu Asp Leu  Pro Gln Pro His Asn  Ser Gly Asn 
    2135                 2140                 2145             


Gln Glu  Leu Glu Asn His Leu  Ile Phe Trp Asp Glu  Leu Val Asn 
    2150                 2155                 2160             


Val Leu  Ala Lys Phe Ala Thr  Ser Lys Asn Gln Ser  Leu Lys Asn 
    2165                 2170                 2175             


Arg Thr  Thr Lys Arg Asn Ser  Pro Lys Asn Ser Glu  Asn Leu Thr 
    2180                 2185                 2190             


Thr Thr  Glu Thr Ile Cys Arg  Lys Asn Ile Leu Ala  Asn Met Glu 
    2195                 2200                 2205             


Asn Leu  Pro Ser Asp Asn Gln  Asn Phe Asp Ser Glu  Lys Leu Asp 
    2210                 2215                 2220             


Leu Pro  Gln Pro His Asn Ser  Gly Thr Gln Glu Leu  Glu Asn Ser 
    2225                 2230                 2235             


Asp Ile  Phe Trp Asp Lys Ile  Val Ser Ile Glu Pro  Val Gly Glu 
    2240                 2245                 2250             


Lys Gln  Val Tyr Asp Leu Thr  Val Pro Glu Thr His  Asn Phe Val 
    2255                 2260                 2265             


Ala Asn  Asp Ile Cys Leu His  Asn Ser Thr Tyr Ala  Ser Leu Asn 
    2270                 2275                 2280             


Gly Thr  Ser Met Ala Thr Pro  His Val Ala Gly Ala  Ala Ala Leu 
    2285                 2290                 2295             


Val Lys  Gln Lys Asn Pro Ser  Trp Ser Asn Val Gln  Ile Arg Asn 
    2300                 2305                 2310             


His Leu  Lys Asn Thr Ala Thr  Ser Leu Gly Ser Thr  Asn Leu Tyr 
    2315                 2320                 2325             


Gly Ser  Gly Leu Val Asn Ala  Glu Ala Ala Thr Arg  
    2330                 2335                 2340 


<210>  427
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ter_DnaE-2

<400>  427

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ser Gly Ser Thr Lys Val Ile Asp Ala Ala Thr Gly 
    290                 295                 300                 


Asn Leu Phe Ser Leu Lys Glu Ile Ala Ala Gln Pro Glu Tyr Trp Leu 
305                 310                 315                 320 


Ser Arg Lys Val Phe Ser Leu Asp Leu Lys Ser Gln Gln Val Val Gln 
                325                 330                 335     


Gln Pro Ile Thr Glu Ile His Pro Asn Gly Val Arg Asp Val Trp Gln 
            340                 345                 350         


Ile Thr Thr Arg Thr Asn Arg Lys Val Cys Ala Thr Asp Asp His Leu 
        355                 360                 365             


Phe Tyr Thr Val Leu Gly Trp Lys Pro Leu Lys Asp Phe Ser Val Gly 
    370                 375                 380                 


Asp Arg Leu Gly Leu Pro Asn Lys Ile Pro Ile Asn Tyr Arg Ser Gln 
385                 390                 395                 400 


Ile Ser Asp Ser Lys Val Lys Phe Thr Ala Tyr Leu Ile Gly Glu Gly 
                405                 410                 415     


Tyr Leu Tyr Thr Asn Ser Phe Ser Cys Ser Tyr Phe Cys Asn Ser Asp 
            420                 425                 430         


Gly Glu Leu Ile Ala Asp Phe Tyr Gly Cys Ala Glu Glu Leu Phe Gly 
        435                 440                 445             


Ser Ser Ala Pro Ile Glu Lys Gln Leu His Leu Gly Asn Lys Ser Val 
    450                 455                 460                 


Ile Tyr Val Arg Ile Gly Leu Ile Ser Gly Leu Lys Asn Trp Val Asp 
465                 470                 475                 480 


Ser Tyr Leu Gln Cys Ala Asn Ser Arg Val Gln Glu Ile Pro Asn Trp 
                485                 490                 495     


Ile Phe Ser Leu Ser Gln Ser Gln Leu Gln Leu Phe Leu Gly Ile Leu 
            500                 505                 510         


Trp Ser Thr Ser Gly Ile Phe Asp Glu Thr Ile Gly Tyr Thr Tyr Tyr 
        515                 520                 525             


Ser Ser Asn Ser Glu Val Leu Val Arg Gln Val Gln His Leu Phe Leu 
    530                 535                 540                 


Arg Leu Gly Ile Val Ser Leu Phe Asn Val Asn Lys Val Lys Gly Gln 
545                 550                 555                 560 


Gly Glu Leu Asp Val Ser Tyr Val Val Glu Val Arg Gly Arg Glu Asp 
                565                 570                 575     


Met Leu Lys Phe Tyr Lys Leu Ile Lys Pro Tyr Leu Ser Ser Tyr Lys 
            580                 585                 590         


Gln Gly Leu Cys Glu Ser Cys Tyr Leu Val Ile Lys Tyr Gln Gln Ser 
        595                 600                 605             


Tyr Gln Phe Lys Tyr Phe Leu Thr Pro Asp Phe Phe Asp Leu Ile Val 
    610                 615                 620                 


Lys Ala Lys Lys Ala Ser Ser Met Thr Arg Ala Leu Gly Val Cys Gly 
625                 630                 635                 640 


Gly Glu Ile Ser Ser Val Trp Asn Phe Gln Asn Thr Ser Asn Arg Ser 
                645                 650                 655     


Leu Ser Phe Asp Lys Phe Asn Asn Phe Ser Thr Val Leu Ala Asp Glu 
            660                 665                 670         


Glu Leu Thr Ala Ile Ala Asn Ser Asp Val Phe Trp Asp Glu Ile Ile 
        675                 680                 685             


Ser Ile Glu Tyr Ile Gly Lys Glu Glu Val Phe Asp Leu Thr Ile Pro 
    690                 695                 700                 


Glu Thr His Asn Phe Ile Ala Asn Asp Phe Ile Val His Asn Ser Thr 
705                 710                 715                 720 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
                725                 730                 735     


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
            740                 745                 750         


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
        755                 760                 765             


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780         


<210>  428
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Ter_DnaE-3nc_NC-terminal

<400>  428

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Tyr Glu Thr Glu Ile Met Thr Val Glu Tyr Gly 
    290                 295                 300                 


Pro Leu Pro Ile Gly Lys Ile Val Glu Tyr Arg Ile Glu Cys Thr Val 
305                 310                 315                 320 


Tyr Thr Val Asp Lys Asn Gly Tyr Ile Tyr Thr Gln Pro Ile Ala Gln 
                325                 330                 335     


Trp His Asn Arg Gly Met Gln Glu Val Tyr Glu Tyr Ser Leu Glu Asp 
            340                 345                 350         


Gly Thr Val Ile Arg Ala Thr Pro Glu His Lys Phe Met Thr Glu Asp 
        355                 360                 365             


Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Asn Leu Asp Leu 
    370                 375                 380                 


Lys Cys Leu Gly Thr Leu Glu Met Val Lys Ile Val Ser Arg Lys Leu 
385                 390                 395                 400 


Ala Lys Thr Glu Asn Val Tyr Asp Ile Gly Val Thr Lys Asp His Asn 
                405                 410                 415     


Phe Val Leu Ala Asn Gly Leu Ile Ala Ser Asn Ser Thr Tyr Ala Ser 
            420                 425                 430         


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
        435                 440                 445             


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
    450                 455                 460                 


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
465                 470                 475                 480 


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                485                 490     


<210>  429
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ter_Ndse-2

<400>  429

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Leu Thr Gly Asp Gln Lys Val Leu Tyr Tyr Ile Ala Lys 
    290                 295                 300                 


Lys Leu Tyr Tyr Glu Thr Phe Ala Glu Cys Tyr Asp Arg Ile Asn Gly 
305                 310                 315                 320 


Asp Ile Ser Ser Val Ser Val Pro Cys Phe Asp Glu Asn Tyr Gln Thr 
                325                 330                 335     


Val Ile Lys Pro Ile Ser Ala Ile Trp Lys His His Val Lys Lys Lys 
            340                 345                 350         


Gly Phe Lys Ile Lys Ile Thr Trp Gly Lys Gln Ile Lys Ile Thr Glu 
        355                 360                 365             


Asp His Ser Leu Phe Thr Arg Asn Glu Asn Asn Lys Pro Gln Ala Val 
    370                 375                 380                 


Phe Gly Asn Glu Ile Lys Val Gly Asp Glu Ile Gly Ile Pro Ser Tyr 
385                 390                 395                 400 


Ile Ser Phe Leu Glu Gln Pro Leu Glu Pro Phe His Ile Thr Asp Lys 
                405                 410                 415     


Ile Leu Ile Gln Glu Glu Ile Tyr Val Glu Ser Glu Asp Thr Ile Ser 
            420                 425                 430         


Tyr Ile Glu Lys Tyr Gly Asp Lys Met Arg Glu Tyr Leu Leu Ala Lys 
        435                 440                 445             


Ser Leu Ser Pro Ser Gln Phe Tyr Ser Ile Leu Lys Thr Tyr Glu Ala 
    450                 455                 460                 


Lys Asn Gln Ile Pro Trp His Leu Trp Lys Tyr Leu Glu Leu Pro Leu 
465                 470                 475                 480 


Ser Glu Lys Asp Lys Val Cys Tyr Leu Ser Lys Lys Ala Ile Lys Asn 
                485                 490                 495     


Trp Ile Asp Asn Val Glu Glu Leu Leu Trp Phe Leu Gly Phe Tyr Val 
            500                 505                 510         


Ala Arg Gly Ser Leu Ile Lys Asn Glu Val Val Leu Lys Gly Glu Pro 
        515                 520                 525             


Ser Gln Leu Glu Lys Val Ile Glu Leu Ile Glu Arg Ile Phe Glu Tyr 
    530                 535                 540                 


Lys Ser Glu Ile Asn Asp Ser Gly Tyr Ile Ser Ile Lys Ser Lys Ile 
545                 550                 555                 560 


Leu Val Asp Leu Ile Gly Tyr Gly Leu Asn Phe Gly Asn Gln Glu Lys 
                565                 570                 575     


Asp Ile Pro Asn Trp Ile Leu Gln Leu Pro Glu Gln Gln Leu Ile Arg 
            580                 585                 590         


Phe Leu Lys Gly Phe Val Ala Gly Asn Asn Leu Glu Asn Gln Leu Asn 
        595                 600                 605             


Phe Tyr Leu Glu Phe Lys Thr Asp Ser Gln Leu Val Ala Glu Lys Leu 
    610                 615                 620                 


Val Leu Ile Leu Ser Lys Phe Gly Leu Val Ala Asp Val Ser Glu Ile 
625                 630                 635                 640 


Glu Val Asn Glu Glu Asp Ile Ala Lys Ile Tyr Arg Ile Ile Ile Glu 
                645                 650                 655     


Gly Leu Glu Asp Lys Asn Ile His Asn Leu Ser Lys Val Glu Gln Lys 
            660                 665                 670         


Ile Ser Ala Leu Thr Thr Gly Asp Ile Ala Trp Gly Lys Ile Glu Ser 
        675                 680                 685             


Ile Glu Glu Phe Glu Ile Asp Asp Tyr Val Tyr Asp Phe Ser Val Pro 
    690                 695                 700                 


Asn Tyr Glu Asn Phe Ile Gly Gly Ser Tyr Asn Val Phe Ala His Asn 
705                 710                 715                 720 


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
                725                 730                 735     


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
            740                 745                 750         


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
        755                 760                 765             


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775                 780                 


<210>  430
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ter_RIR1-3

<400>  430

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ser Gly Asp Thr Leu Leu Ile Thr Arg Asp Ser Ile 
    290                 295                 300                 


His Lys Ile Lys Asp Val Val Gly Gln Lys Ile Glu Ile Trp Asn Gly 
305                 310                 315                 320 


Lys Asn Trp Ser Gln Val Ile Pro Leu Lys Thr Gly Lys Asp Arg Lys 
                325                 330                 335     


Leu Tyr Arg Val Arg Phe Gly Asp Gly Ser Tyr Leu Asp Val Thr Glu 
            340                 345                 350         


Tyr His Arg Phe Phe Val Lys Asp Arg Phe Gly Lys Lys Tyr Glu Glu 
        355                 360                 365             


Val Gln Thr Lys Asp Leu Leu Thr His Ser Lys Tyr Ala Leu Asp Val 
    370                 375                 380                 


Glu Pro Phe Ile Ile Asp Tyr His Asp Gly Asp Ser Ile Asn Leu Ser 
385                 390                 395                 400 


Tyr Ala Tyr Thr Leu Gly Ala Ala Leu Gly Asn Gly Thr Ile Asp Gln 
                405                 410                 415     


Asn Ser Asn Gly Lys Ile Arg Val Tyr Ser His Lys Ala Glu Leu Ile 
            420                 425                 430         


Phe Ala Gly Asn Lys Ser Leu Glu Arg Gln Tyr Asn Tyr Leu Pro Ser 
        435                 440                 445             


Phe Val Asp Val Ile Asp Leu Gly Phe Ser Gly Glu Leu Leu Arg Arg 
    450                 455                 460                 


Leu Gln Thr Glu Pro Asp Ala Leu Asn Thr Ile Ala Ser Trp Asn Lys 
465                 470                 475                 480 


Ser Ala Ile Leu Ala Phe Ile Ala Gly Leu Ala Asp Thr Asp Gly Ser 
                485                 490                 495     


Glu Thr Lys Gly Asn Gly Ile Lys Ile Ser Val Ser Asp Tyr Glu Arg 
            500                 505                 510         


Ala Lys Arg Leu Gln Leu Leu Leu Thr Lys Cys Gly Ile Arg Ala Ser 
        515                 520                 525             


Val Asn Leu Met Ala Ser Arg Gly Cys Thr Thr Asn Leu Gly Glu Arg 
    530                 535                 540                 


Asn Gln Asp Leu Tyr Tyr Leu Gln Ile Thr Asp Cys Arg Glu Ile Pro 
545                 550                 555                 560 


Cys Gln Arg Leu Asp Thr Thr Lys Val Cys Glu Ala Lys Phe Gln Gly 
                565                 570                 575     


Lys Tyr Gln Thr Ile Gln Asn Val Glu Glu Leu Pro Gly Leu His Asp 
            580                 585                 590         


Thr Tyr Cys Phe Glu Glu Pro Glu Phe His Lys Gly Val Phe Gly Asn 
        595                 600                 605             


Ala Leu Thr Gly Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
    610                 615                 620                 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
625                 630                 635                 640 


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
                645                 650                 655     


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
            660                 665                 670         


Glu Ala Ala Thr Arg 
        675         


<210>  431
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ter_RIR1-4

<400>  431

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Asp Lys Thr Ala Leu Arg Ile Phe Asn Gln Gly Leu 
    290                 295                 300                 


Leu Tyr Ala Asp Glu Val Val Thr Pro Gly Ser Gly Glu Thr Val Gly 
305                 310                 315                 320 


Leu Gly Leu Thr Val Arg Asn Gly Ile Gly Ala Ser Thr Ala Ile Ala 
                325                 330                 335     


Asn Gln Pro Met Glu Leu Val Glu Ile Lys Leu Ala Asn Gly Arg Lys 
            340                 345                 350         


Leu Arg Met Thr Pro Asn His Arg Met Ser Val Lys Gly Lys Trp Ile 
        355                 360                 365             


His Ala Cys Asn Leu Lys Pro Gly Met Leu Leu Asp Tyr Ser Ile Gly 
    370                 375                 380                 


Glu Tyr Gln Lys Arg Glu Asp Thr Leu Leu Ile Pro Leu Gln Leu Glu 
385                 390                 395                 400 


Asp Tyr Thr Glu Val Asn Asn Ser Gln Thr Leu Gly His Asn Gly Gly 
                405                 410                 415     


Val Leu Thr Lys Lys Ile Met Thr Pro Ala Ser Met Thr Ser Asp Leu 
            420                 425                 430         


Ala Tyr Phe Leu Gly Cys Leu Phe Gly Asn Gly Cys Ile Val Gln Asn 
        435                 440                 445             


Lys Tyr Gln Val Cys Phe Tyr His Ser Arg Leu Asp Val Leu Tyr Gly 
    450                 455                 460                 


Leu Gln Glu Lys Gly Lys Lys Leu Phe Gly Ile Lys Gly Ser Leu Asn 
465                 470                 475                 480 


Asp Phe Ala Asn Gly Arg Phe Glu Leu Cys Phe Ala Ser Arg Gln Leu 
                485                 490                 495     


Phe Tyr Trp Leu His Leu Asn Gln Leu Val Lys Thr Gln Lys Ser Glu 
            500                 505                 510         


Asp Leu Glu Arg Ile Pro Leu Ser Leu Arg Arg Ser Ser Arg Val Thr 
        515                 520                 525             


Leu Leu Ser Phe Phe Cys Gly Leu Ile Asp Thr Asn Gly Tyr Val Pro 
    530                 535                 540                 


Gln Asp Gly Lys Leu Ser Ile Ala Ser Ala Ser Ser Asp Phe Ile His 
545                 550                 555                 560 


Asn Leu Gln Gln Ile Gly Glu Ser Ile Gly Leu Cys Phe Ser Ile Tyr 
                565                 570                 575     


Gln Asn Thr Lys Gly Glu Asn Leu Gln Asn Gln His Asn Asn Thr Trp 
            580                 585                 590         


Gly Leu Cys Leu Ser Pro Met Leu Ser Asn Val Asp Ala Leu Asp Tyr 
        595                 600                 605             


Leu Asn His Asn Ser Ile Lys Cys Gln Glu Gly Pro Val Val Ile Ser 
    610                 615                 620                 


Lys Cys Val Leu Asn Tyr Ser Pro Tyr Lys Ile Glu Ser Val Asn Ile 
625                 630                 635                 640 


Gly Ala Val Cys Asp Tyr Ser Tyr Asp Phe Ala Ile Glu Gly Ile Asn 
                645                 650                 655     


Asp Asn Asp Ser Trp Tyr Trp Gln Gly Ala Leu Lys Ser His Asn Ser 
            660                 665                 670         


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
        675                 680                 685             


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
    690                 695                 700                 


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
705                 710                 715                 720 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                725                 730                 735 


<210>  432
<211>  823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ter_Snf2

<400>  432

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Leu His Asp Thr Glu Ile Tyr Val Asn Gly Met Val 
    290                 295                 300                 


Met Glu Ala Glu Gln Ile Trp Gln Ala Tyr Ala Gly Glu Ala Glu Phe 
305                 310                 315                 320 


Asp Gly Glu Gly Phe Trp Thr Glu Pro Asn Lys Glu Leu Leu Val Asn 
                325                 330                 335     


Ser Leu Asp Glu Thr Thr Gly Lys Ile Val Phe Ala Arg Ile Arg Arg 
            340                 345                 350         


Leu Tyr Arg Gln Trp Val Arg Glu Lys Leu Arg Lys Val Arg Leu Lys 
        355                 360                 365             


Asp Gly Ser Ser Ile Thr Ile Thr Cys Arg His Lys Leu Phe Ile Arg 
    370                 375                 380                 


Asp Ser Trp Lys Asn Asp Phe Gln Val Gly Asp Asp Val Cys Val Pro 
385                 390                 395                 400 


Ala Lys Leu Met Trp Asp Gly Lys Pro Glu Asp Pro Asp Val Val Lys 
                405                 410                 415     


Phe Val Ala Trp Gln Val Ala Glu Gly Trp Glu Arg Val Asn Ser Gly 
            420                 425                 430         


Met Phe Gly Val Ser Gln Lys Gly Lys Asp Val Leu Glu Gly Leu Leu 
        435                 440                 445             


Glu Val Phe Ser Arg Leu Gly Lys Arg Tyr Asp Ile Lys Ile Asn Cys 
    450                 455                 460                 


Pro Lys Val Val Ala His Gly Ser Lys Lys Asn Cys Tyr Glu Phe Ser 
465                 470                 475                 480 


Ala His Ser Leu Glu Tyr Arg Lys Phe Leu Glu Glu Lys Arg Tyr Gly 
                485                 490                 495     


Trp Gly Lys Arg Ser His Glu Lys Thr Ile Pro Leu Phe Ile Met Gln 
            500                 505                 510         


Ala Asp Leu Asp Ser Val Arg Val Phe Leu Ser Asn Tyr Phe Asp Ala 
        515                 520                 525             


Glu Gly Trp Val Asn Lys Thr Val Arg Cys Val Glu Ile Ser Thr Ala 
    530                 535                 540                 


Ser Ser Gln Leu Ile Gln Glu Leu Ser Ile Leu Leu Arg Arg Phe Gly 
545                 550                 555                 560 


Val Trp Met Lys Ile Ser Pro Gln Gln Lys Cys Ala Thr Asn Gly Thr 
                565                 570                 575     


Gly Val Phe Cys Thr Tyr Tyr Ile Gly Thr Phe Gly Gly Asn Ser Ala 
            580                 585                 590         


Arg Cys Phe Leu Gln Glu Ile Gly Phe Asn Asp Ser Gly Lys Gln Glu 
        595                 600                 605             


Asn Leu Lys Ser Ile Cys Glu Lys Ile Ala Asp Ser Asn Val Glu Gly 
    610                 615                 620                 


Ile Pro Ala Ser Asp Ile Val Ala Glu Leu Val Glu Lys Thr Gln Leu 
625                 630                 635                 640 


Pro Val Gly Ser Leu Gly Ile Gln Asp Pro Ile Tyr Met Asp Gly Cys 
                645                 650                 655     


Gln Asp Phe Ser Pro Thr Ser Leu Glu Lys Val Ile Asn Ser Ile Glu 
            660                 665                 670         


Asp Ile Ile Ser Gly Ala Gly Glu Glu Glu Tyr Gly Gln Leu Lys Ser 
        675                 680                 685             


Ser Lys Leu Arg Asn Lys Thr Leu Glu Ala Tyr Ser Leu Leu Asn Ile 
    690                 695                 700                 


Leu Glu Leu Glu Ile Tyr Lys Thr Arg Leu Gln Lys Leu Leu Asn Gln 
705                 710                 715                 720 


Glu Val Tyr Tyr Cys Gln Ile Glu Ser Ile Glu Glu Met Glu Tyr Glu 
                725                 730                 735     


Gly Trp Val Tyr Asp Phe Glu Val Ser Lys Tyr His Asn Phe Val Ala 
            740                 745                 750         


Asn Asn Ile Ile Cys His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
        755                 760                 765             


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
    770                 775                 780                 


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
785                 790                 795                 800 


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
                805                 810                 815     


Asn Ala Glu Ala Ala Thr Arg 
            820             


<210>  433
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tfu_Pol-2

<400>  433

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Val Thr Gly Asp Thr Glu Val Thr Ile Arg Arg Asn Gly 
    290                 295                 300                 


Arg Ile Glu Phe Val Pro Ile Glu Lys Leu Phe Glu Arg Val Asp His 
305                 310                 315                 320 


Arg Val Gly Glu Lys Glu Tyr Cys Val Leu Gly Gly Val Glu Ala Leu 
                325                 330                 335     


Thr Leu Asp Asn Arg Gly Arg Leu Val Trp Lys Lys Val Pro Tyr Val 
            340                 345                 350         


Met Arg His Lys Thr Asp Lys Arg Ile Tyr Arg Val Trp Phe Thr Asn 
        355                 360                 365             


Ser Trp Tyr Leu Asp Val Thr Glu Asp His Ser Leu Ile Gly Tyr Leu 
    370                 375                 380                 


Asn Thr Ser Lys Val Lys Pro Gly Lys Pro Leu Lys Glu Arg Leu Val 
385                 390                 395                 400 


Glu Val Lys Pro Glu Glu Leu Gly Gly Lys Val Lys Ser Leu Ile Thr 
                405                 410                 415     


Pro Asn Arg Pro Ile Ala Arg Thr Ile Lys Ala Asn Pro Ile Ala Val 
            420                 425                 430         


Lys Leu Trp Glu Leu Ile Gly Leu Leu Val Gly Asp Gly Asn Trp Gly 
        435                 440                 445             


Gly Gln Ser Asn Trp Ala Lys Tyr Tyr Val Gly Leu Ser Cys Gly Leu 
    450                 455                 460                 


Asp Lys Ala Glu Ile Glu Arg Lys Val Leu Asn Pro Leu Arg Glu Ala 
465                 470                 475                 480 


Ser Val Ile Ser Asn Tyr Tyr Asp Lys Ser Lys Lys Gly Asp Val Ser 
                485                 490                 495     


Ile Leu Ser Lys Trp Leu Ala Gly Phe Met Val Lys Tyr Phe Lys Asp 
            500                 505                 510         


Glu Asn Gly Asn Lys Ala Ile Pro Ser Phe Met Phe Asn Leu Pro Arg 
        515                 520                 525             


Glu Tyr Ile Glu Ala Phe Leu Arg Gly Leu Phe Ser Ala Asp Gly Thr 
    530                 535                 540                 


Val Ser Leu Arg Arg Gly Ile Pro Glu Ile Arg Leu Thr Ser Val Asn 
545                 550                 555                 560 


Arg Glu Leu Ser Asp Ala Val Arg Lys Leu Leu Trp Leu Val Gly Val 
                565                 570                 575     


Ser Asn Ser Leu Phe Thr Glu Thr Lys Pro Asn Arg Tyr Leu Glu Lys 
            580                 585                 590         


Glu Ser Gly Thr His Ser Ile His Val Arg Ile Lys Asn Lys His Arg 
        595                 600                 605             


Phe Ala Asp Arg Ile Gly Phe Leu Ile Asp Arg Lys Ser Thr Lys Leu 
    610                 615                 620                 


Ser Glu Asn Leu Gly Gly His Thr Asn Lys Lys Arg Ala Tyr Lys Tyr 
625                 630                 635                 640 


Asp Phe Asp Leu Val Tyr Pro Arg Lys Ile Glu Glu Ile Thr Tyr Asp 
                645                 650                 655     


Gly Tyr Val Tyr Asp Ile Glu Val Glu Gly Thr His Arg Phe Phe Ala 
            660                 665                 670         


Asn Gly Ile Leu Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
        675                 680                 685             


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
    690                 695                 700                 


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
705                 710                 715                 720 


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
                725                 730                 735     


Asn Ala Glu Ala Ala Thr Arg 
            740             


<210>  434
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tfus_RecA-1

<400>  434

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Thr Ala Asp Thr Tyr Val Trp Thr Asp Arg Gly Leu 
    290                 295                 300                 


Glu Thr Val Ala Glu Val Phe Gly Arg Ala Gly Leu Pro Leu Ser Ser 
305                 310                 315                 320 


Thr Ser Arg Val Thr Asp Val Arg Asp Arg Asp Ile Arg Val Val Asn 
                325                 330                 335     


Glu Lys Gly Glu Leu Glu Gln Val Ala Ala Leu Thr His Asn Gly Arg 
            340                 345                 350         


Gln Pro Val Val Arg Ile Thr Val Ala Ser Gly Arg Gln Val Thr Val 
        355                 360                 365             


Thr Arg Asn His Pro Leu Arg Val Met Asn Asp Asp Gly Phe Ile Val 
    370                 375                 380                 


Trp Arg Glu Ala Gly Gln Leu Arg Glu Gly Asp Val Leu Val Ser Ala 
385                 390                 395                 400 


Ala Phe Gly Ala Val Gln Ala Ala Ser Gly Gly Gly Leu Ser Glu Asp 
                405                 410                 415     


Glu Ala Val Leu Leu Gly Tyr Leu Thr Ala Ala Gly Ser Leu Asp Pro 
            420                 425                 430         


Ala Gly His Val Cys Phe Thr Thr Thr Asp Ile Glu Thr Gly Ala Glu 
        435                 440                 445             


Phe Ala Ala Leu Ala Glu Trp Leu Leu Asp Thr Thr Val Thr Ala Val 
    450                 455                 460                 


Pro Gly Asp Gly Gln Val Ala Tyr Val Leu Ser Asp Pro Ala Ala Arg 
465                 470                 475                 480 


His Thr Leu Ala Glu Arg Tyr Gly Val Asp Tyr Ala Ala Ala Ala Arg 
                485                 490                 495     


Ile Pro Gln Cys Val Arg Thr Ala Gly Asp Lys Met Gln Arg Ala Phe 
            500                 505                 510         


Leu Ala Ala Leu Tyr Thr Ala Ala Gly Trp Thr Asp Thr Ser Ala Ala 
        515                 520                 525             


Val Gly Leu Arg Thr Ala Ser Ala Pro Leu Ala Arg Glu Val Gln Tyr 
    530                 535                 540                 


Leu Leu Tyr Gly Leu Gly Ile Pro Ala Asp Leu Asp Arg Ser His Gly 
545                 550                 555                 560 


Asn Gly Gln His Pro Trp Ala Val Thr Ile Ser Pro Ala Ala Ala Pro 
                565                 570                 575     


Arg Phe His Thr Glu Val Gly Phe Arg Thr Ala Gln Gln Ser Pro Gln 
            580                 585                 590         


Thr Gly Leu His Glu Pro Thr Pro Gln Val Glu Ala Ile Pro Asn Leu 
        595                 600                 605             


Thr Gly Leu Ile His Ala Leu Arg Asp Ser Ile Gly Asp Arg Ala Glu 
    610                 615                 620                 


Ser Thr Asp Asp Pro Phe Pro Ala Ala Ser Gly Gly Ala Tyr Asp Arg 
625                 630                 635                 640 


Asp Gln Val Arg Arg Val Ile Asp Trp Ala Lys Arg Arg Thr Asp Glu 
                645                 650                 655     


Ala Pro Ala Thr Ala Asn Ala Ile Leu Gly Tyr Leu Thr Gln Leu Thr 
            660                 665                 670         


Asp Ala Arg Tyr Thr Tyr Glu Pro Ile Thr Ala Val Glu Asp Ala Gly 
        675                 680                 685             


Gln Gln Pro Thr Phe Asp Leu Met Val Pro Arg Thr His Ser Phe Leu 
    690                 695                 700                 


Ala Asn Gly Ile Leu Ser His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
705                 710                 715                 720 


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
                725                 730                 735     


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
            740                 745                 750         


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
        755                 760                 765             


Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775     


<210>  435
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tfus_RecA-2

<400>  435

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Met His Tyr Asp Thr Leu Val Thr Leu Ala Asp Gly Thr 
    290                 295                 300                 


Gln Glu Lys Ile Gly Thr Ile Val Asp Arg Lys Leu Asp Val Glu Val 
305                 310                 315                 320 


Leu Ser Tyr Asp Pro Glu Thr Asp Arg Ile Val Pro Arg Arg Val Val 
                325                 330                 335     


Asn Trp Phe Asp Asn Gly Ala Ala Asp His Phe Leu Gln Phe Thr Val 
            340                 345                 350         


Gly Arg Ser Gly Lys Pro Gly Gly Ala Gln Phe Thr Ala Thr Pro Asn 
        355                 360                 365             


His Leu Ile Arg Thr Pro Gly Gly Trp Arg Glu Ala Gly Glu Leu Ile 
    370                 375                 380                 


Ala Gly Asp Arg Val Leu Val His Glu Pro His Tyr Leu Asn Glu Gln 
385                 390                 395                 400 


Gln Arg Gln Val Val Tyr Gly Ser Leu Met Gly Arg Gly Thr Leu Val 
                405                 410                 415     


Pro Asp Arg His Gly Gly Pro Gly Val His Phe Cys Met Ala His Thr 
            420                 425                 430         


Ala Glu Gln Ala Ala Tyr Leu Asp Trp Lys Val Ser Leu Leu Gly Asn 
        435                 440                 445             


Ile Ala His Ser Arg Thr Ala Glu Ala Ser Ala Thr Val Gly Val Glu 
    450                 455                 460                 


Phe Thr Pro Met Pro Glu Leu Ser Glu Leu His Arg Val Val Asp Phe 
465                 470                 475                 480 


Gly Asp Gly His Thr His Leu Thr Trp Glu Phe Leu Lys Gln Leu Thr 
                485                 490                 495     


Pro Leu Ala Leu Ala Val Trp Tyr Leu Asp Ala Gly Thr Leu Thr Ile 
            500                 505                 510         


Pro Gln Ser Gly Thr Asp Asp Asp Ala Arg Val Gln Ile Asp Val Glu 
        515                 520                 525             


Thr Leu Ser Pro Gly Ser Arg Gln Arg Leu Val Glu Tyr Leu Arg Asp 
    530                 535                 540                 


Thr His Glu Leu Asp Ala Ala Val Val Gln Gln Gly Ala Asp Ala Arg 
545                 550                 555                 560 


Ser Leu Leu Glu Phe Thr Pro Ala Ala Thr Val Arg Phe Leu Glu Leu 
                565                 570                 575     


Val Ala Pro Tyr Val Pro Glu Ser Met Ser Ser Met Leu Leu Ala Gln 
            580                 585                 590         


Phe Arg Gly Arg Cys Ser Val Thr Pro Glu Tyr Ser Asp Pro Val Gln 
        595                 600                 605             


Arg Leu Val Ala Ala Pro Val Leu Asp Ile Gln Val Lys Pro Gly Ser 
    610                 615                 620                 


Thr Arg Lys Phe Asp Ile Glu Val Glu Gly Asn His Asn Tyr Phe Val 
625                 630                 635                 640 


Asp Gly Val Met Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr 
                645                 650                 655     


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
            660                 665                 670         


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
        675                 680                 685             


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
    690                 695                 700                 


Asn Ala Glu Ala Ala Thr Arg 
705                 710     


<210>  436
<211>  891
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Thy_Pol-1

<400>  436

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Leu Leu Pro Glu Glu Trp Ile Pro Leu Val Glu Asn Gly 
    290                 295                 300                 


Lys Val Arg Leu His Arg Ile Gly Glu Phe Val Asp Lys Leu Met Glu 
305                 310                 315                 320 


Thr Asp Ser Glu Leu Val Lys Arg Asn Gly Asp Thr Glu Val Leu Glu 
                325                 330                 335     


Val Arg Gly Ile Arg Ala Leu Ser Phe Asp Arg Lys Ser Lys Lys Ala 
            340                 345                 350         


Arg Val Met Pro Val Lys Ala Val Ile Arg His Arg Tyr Ser Gly Asp 
        355                 360                 365             


Val Tyr Glu Ile Val Leu Gly Ser Gly Arg Arg Ile Thr Val Thr Glu 
    370                 375                 380                 


Gly His Ser Leu Phe Ala Tyr Gly Asp Gly Glu Leu Arg Glu Val Thr 
385                 390                 395                 400 


Gly Gly Glu Ile Lys Ala Gly Asp Leu Leu Ala Val Pro Arg Arg Val 
                405                 410                 415     


Asn Leu Pro Glu Lys Lys Glu Arg Leu Asn Leu Val Glu Leu Leu Arg 
            420                 425                 430         


Arg Leu Pro Glu Glu Glu Thr Gly Asp Ile Ile Leu Thr Ile Pro Val 
        435                 440                 445             


Lys Gly Arg Lys Asn Phe Phe Lys Gly Met Leu Arg Thr Leu Arg Trp 
    450                 455                 460                 


Ile Ser Gly Glu Glu Lys Arg Pro Arg Thr Ala Arg Arg Tyr Leu Glu 
465                 470                 475                 480 


His Leu Glu Gly Leu Gly Tyr Val Arg Leu Lys Lys Ile Gly Tyr Glu 
                485                 490                 495     


Val Thr Asp Arg Glu Gly Leu Glu Arg Tyr Arg Lys Leu Tyr Glu Arg 
            500                 505                 510         


Leu Val Glu Ala Val Arg Tyr Asn Gly Asn Lys Arg Glu Tyr Leu Val 
        515                 520                 525             


Glu Phe Asn Ala Val Arg Asp Val Ile Ala Leu Met Pro Glu Glu Glu 
    530                 535                 540                 


Leu Arg Asp Trp Leu Val Gly Thr Arg Asn Gly Phe Arg Met Arg Pro 
545                 550                 555                 560 


Phe Val Glu Ile Glu Glu Asp Phe Ala Lys Leu Leu Gly Tyr Tyr Val 
                565                 570                 575     


Ser Glu Gly Asn Ala Arg Lys Trp Arg Asn Gln Lys Asn Gly Trp Ser 
            580                 585                 590         


Tyr Thr Val Lys Leu Tyr Asn Glu Asn Gln Arg Val Leu Asp Asp Met 
        595                 600                 605             


Glu Ser Leu Ala Glu Arg Phe Phe Gly Arg Val Lys Arg Gly Lys Asn 
    610                 615                 620                 


Tyr Ile Glu Ile Pro Arg Lys Met Ala Tyr Ile Ile Phe Glu Asn Leu 
625                 630                 635                 640 


Cys Gly Thr Leu Ala Glu Asn Lys Arg Val Pro Glu Ala Ile Phe Thr 
                645                 650                 655     


Ser Pro Glu Ser Val Arg Trp Ala Phe Ile Glu Gly Tyr Phe Ile Gly 
            660                 665                 670         


Asp Gly Asp Val His Pro Ser Lys Arg Val Arg Leu Ser Thr Lys Ser 
        675                 680                 685             


Glu Leu Leu Val Asn Gly Leu Val Leu Leu Leu Asn Ser Leu Gly Val 
    690                 695                 700                 


Ser Ala Ile Lys Ile Arg His Asp Ser Gly Val Tyr Arg Val Tyr Val 
705                 710                 715                 720 


Asn Glu Glu Leu Pro Phe Thr Asp Tyr Arg Lys Lys Lys Asn Ala Tyr 
                725                 730                 735     


Tyr Ser His Val Ile Pro Lys Glu Ile Leu Glu Glu Thr Phe Gly Lys 
            740                 745                 750         


Val Phe Gln Arg Ser Val Ser Tyr Glu Lys Phe Arg Glu Leu Val Lys 
        755                 760                 765             


Ser Glu Lys Leu Asp Gly Glu Lys Ala Lys Arg Ile Glu Trp Leu Leu 
    770                 775                 780                 


Asn Gly Asp Val Val Leu Asp Lys Val Leu Glu Val Lys Lys Arg Pro 
785                 790                 795                 800 


Tyr Glu Gly Tyr Val Tyr Asp Leu Ser Val Glu Glu Asp Glu Asn Phe 
                805                 810                 815     


Leu Ala Gly Phe Gly Leu Leu Tyr Ala His Asn Ser Thr Tyr Ala Ser 
            820                 825                 830         


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
        835                 840                 845             


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
    850                 855                 860                 


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
865                 870                 875                 880 


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                885                 890     


<210>  437
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tko_CDC21-2

<400>  437

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Tyr His His Asp Phe Glu Leu Leu Leu Ala Asp Gly Arg 
    290                 295                 300                 


Lys Val Lys Ile Gly Glu Leu Val Asp Lys Leu Ile Glu Lys Asn Arg 
305                 310                 315                 320 


Asp Arg Val Ile Leu Gly Lys Asp Thr Glu Ile Leu Pro Val Glu Asp 
                325                 330                 335     


Ile Glu Leu Leu Ala Tyr Asp Leu Glu Lys Arg Glu Ile Val Lys Val 
            340                 345                 350         


Lys Ala Asp Arg Val Ser Arg His Lys Ala Pro Glu Arg Phe Ile Lys 
        355                 360                 365             


Leu Arg Phe Ser Asn Gly Arg Glu Ile Thr Val Thr Pro Glu His Pro 
    370                 375                 380                 


Val Met Val Trp Glu Asn Gly Glu Ile Thr Glu Lys Pro Ala Glu Lys 
385                 390                 395                 400 


Ile Thr Pro Gly Asp Ile Ala Leu Gly Val Leu Arg Tyr Pro Ile Gln 
                405                 410                 415     


Val Asp Gly Lys Phe Lys Glu Arg Tyr Arg Asp Met Arg Glu Ala Glu 
            420                 425                 430         


Asp Tyr Gln Asp Tyr Leu Tyr Ser Arg Gly Val Val Ser Lys Ile Lys 
        435                 440                 445             


Arg Thr Gly Ile Tyr Phe Thr Val Glu Lys Ala Arg Arg Ala Leu Pro 
    450                 455                 460                 


Arg Glu Leu Val Lys Pro Leu Ile Asn Ala Gly Lys Ile Leu Arg Val 
465                 470                 475                 480 


Thr Gln Thr Pro Lys Glu Arg Ala Ser Phe Asn Gln Lys Leu Val Arg 
                485                 490                 495     


Glu Asn Ile Ile Glu Gly Tyr Leu Gln Arg Ile Ile Glu Arg Met Asp 
            500                 505                 510         


Glu Leu Glu Arg Leu Ser Arg Glu Asp Pro Ala Lys Ala Leu Glu Leu 
        515                 520                 525             


Leu Pro Lys Thr Gln Leu Tyr Tyr Lys Tyr Gly Ile Thr Tyr Gly Lys 
    530                 535                 540                 


Leu Lys Lys Leu Ala Glu Ala Arg Asn Ser Trp Ala Glu Gly Ile Ile 
545                 550                 555                 560 


Gln Ser Ala Val Ala Glu Arg Ile Ser Leu Ala Lys Arg Glu Leu Glu 
                565                 570                 575     


Glu Phe Phe Lys Trp Trp Asn Ala Asn Val Asn Phe Leu Lys Val Lys 
            580                 585                 590         


Cys Val Glu Glu Ile Lys Asn Asp Arg Trp Glu Trp Val Tyr Asp Val 
        595                 600                 605             


Thr Val Glu Pro His His Leu Phe Val Ser His Gly Leu Val Leu His 
    610                 615                 620                 


Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
625                 630                 635                 640 


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
                645                 650                 655     


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
            660                 665                 670         


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
        675                 680                 685             


Arg 
    


<210>  438
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tko_Helicase

<400>  438

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Met His Pro Asp Thr Tyr Val Val Thr Lys Ser Gly Ala 
    290                 295                 300                 


Lys Lys Val Ser Glu Leu Thr Glu Gly Asp Glu Val Leu Thr His Thr 
305                 310                 315                 320 


Gly Thr Phe Lys Lys Val Ile Gln Pro Leu Arg Arg Glu His Lys Gly 
                325                 330                 335     


Arg Leu Leu Val Ile Lys Ala Tyr Gly Thr Val Pro Val Lys Ile Thr 
            340                 345                 350         


Pro Glu His Met Val Trp Val Val Lys Gln Ile Arg His Lys Ser His 
        355                 360                 365             


Tyr Ser Asp Gly Arg Gln Val Ile Trp Trp Glu Phe Glu Gly Pro Glu 
    370                 375                 380                 


Trp Met Thr Ala Gln Glu Leu Lys Glu Arg Leu Glu Ser Glu Thr Asp 
385                 390                 395                 400 


Pro Lys Val Ser Tyr Met Leu Leu Gln Pro Ile Pro Glu Pro Ser Val 
                405                 410                 415     


Asp Ala Asp Lys Ile Pro Leu Arg Lys Glu Val Tyr Val Val Asn Gln 
            420                 425                 430         


His Gly Lys Thr Asp Lys Leu His Pro Ser Val Lys Arg Thr Pro Glu 
        435                 440                 445             


Tyr Leu Pro Leu Asn Phe Glu Thr Ala Arg Leu Ile Gly Leu Trp Ile 
    450                 455                 460                 


Ala Glu Gly Ser Thr Ser Lys Asn Gly Val Ile Lys Phe Asp Ile Ser 
465                 470                 475                 480 


Ser Asn Glu Glu Asp Leu Thr Glu Phe Ile Thr Gly Thr Ile Arg Lys 
                485                 490                 495     


Tyr Phe Pro His Ala Lys Ile Val Val Lys Asp His Glu Arg Asn Arg 
            500                 505                 510         


Arg Thr Val Arg Phe Cys Asn Lys Arg Phe Ala Glu Trp Leu Arg Glu 
        515                 520                 525             


Asn Ile Gly His Gly Ala Asp Asn Lys Ser Ile Pro Pro Leu Leu Leu 
    530                 535                 540                 


Leu Asn Lys Asn Arg Glu Val Arg Leu Gly Leu Leu Arg Gly Leu Ile 
545                 550                 555                 560 


Glu Gly Asp Gly Tyr Val Arg Arg Glu Ser Gln Arg Arg Ala Asn Tyr 
                565                 570                 575     


Ile Ser Tyr Ser Thr Val Ser Pro Ser Leu Ala Tyr Gln Leu Gln Leu 
            580                 585                 590         


Leu Val Ala Ser Leu Gly Tyr Thr Ser Ser Ile His Arg Ser Ile Arg 
        595                 600                 605             


Thr Glu Gly Ile Gly Lys Thr Arg Lys Pro Ile Tyr Asp Val Lys Val 
    610                 615                 620                 


Ser Gly Lys Ser Tyr Tyr Ser Leu Leu Glu Glu Leu Gly Phe Glu Val 
625                 630                 635                 640 


Pro Gln Arg Gly Asn Arg Thr Tyr Asn Val Asn Arg Thr Trp Lys Asn 
                645                 650                 655     


Tyr Leu Leu Leu Lys Val Arg Ser Ile Glu Glu Glu Glu Tyr Glu Gly 
            660                 665                 670         


Asp Val Tyr Asn Leu Glu Val Glu Gly Asp Glu Ser Gly Ser Val Gly 
        675                 680                 685             


Phe Ile Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
    690                 695                 700                 


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
705                 710                 715                 720 


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
                725                 730                 735     


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
            740                 745                 750         


Glu Ala Ala Thr Arg 
        755         


<210>  439
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tko_IF2

<400>  439

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Leu Pro Asp Glu Lys Val Ile Leu Pro Glu His Gly 
    290                 295                 300                 


Pro Ile Thr Leu Lys Gly Leu Phe Asp Leu Ala Lys Glu Thr Val Val 
305                 310                 315                 320 


Ala Asp Asn Glu Lys Glu Ile Arg Lys Leu Gly Ala Lys Leu Thr Ile 
                325                 330                 335     


Val Gly Glu Asp Gly Arg Leu Arg Val Leu Glu Ser Pro Tyr Val Trp 
            340                 345                 350         


Lys Val Arg His Arg Gly Lys Met Leu Arg Val Lys Leu Lys Asn Trp 
        355                 360                 365             


His Ser Val Ser Val Thr Pro Glu His Pro Phe Leu Thr Thr Arg Gly 
    370                 375                 380                 


Trp Val Arg Ala Asp Gln Leu Lys Pro Gly Asp Tyr Val Ala Val Pro 
385                 390                 395                 400 


Arg Val Ile His Gly Asn Glu Ser Asp Glu Arg Phe Val Ser Phe Val 
                405                 410                 415     


Tyr Glu Lys Leu Lys Asn Asp Glu Leu Ile Ala Lys Leu Arg Gly Glu 
            420                 425                 430         


Val Leu Ser Lys Ile Ser Ser Glu Phe Lys Gly Asp Arg Ala Tyr Lys 
        435                 440                 445             


Val Glu Arg Asn Val Phe Arg Trp Glu Asp Ile Glu Arg Leu Asn Leu 
    450                 455                 460                 


Trp Asp Glu Val Glu Arg Val Ala Phe Thr Pro Arg Met His Arg Ser 
465                 470                 475                 480 


Gly Lys Pro Leu His Tyr Val Lys Leu Pro Arg Ser Pro Glu Glu Trp 
                485                 490                 495     


Glu Ala Phe Phe Tyr Phe Ala Gly Val Met Phe Gly Asp Gly Ser Gln 
            500                 505                 510         


Asp Lys Ile Ala Asn Asn Asp Val Glu Val Tyr Glu Glu Leu Lys Lys 
        515                 520                 525             


Leu Ser Val Leu Gly Val Ala Val Lys Arg Val Glu Arg Thr Thr Ser 
    530                 535                 540                 


Tyr Glu Ile Glu Leu Thr Asn Gly Lys Asn Ala Leu Leu Arg Leu Leu 
545                 550                 555                 560 


Arg Val Leu Phe Glu Tyr Pro Glu Arg Gln Lys Ala Lys Ser Ile Arg 
                565                 570                 575     


Val Pro Arg Ile Leu Phe Ile Ala Pro Arg Lys Tyr Val Ser Arg Phe 
            580                 585                 590         


Leu Arg Gly Tyr Phe Asp Ala Asp Gly His Val Ser Leu Lys Asp Ala 
        595                 600                 605             


Arg Ile Glu Val Thr Ser Ala Ser Gln Glu Phe Leu Glu Asp Leu Ser 
    610                 615                 620                 


Leu Leu Leu Leu Arg Phe Gly Ile Val Ser Lys Ile Tyr Arg Ser Asp 
625                 630                 635                 640 


Tyr Thr Thr Leu Val Ile Ser Gly Arg Arg Asn Leu Asp Leu Phe Arg 
                645                 650                 655     


Arg Tyr Ile Gly Phe Ser Val Lys Asn Lys Ala Glu Ala Leu Glu Lys 
            660                 665                 670         


Ala Ile Lys Lys Ser Arg Arg Ser Glu Ser Tyr Pro Ile Phe Glu Glu 
        675                 680                 685             


Leu Lys Arg Leu Arg Leu Leu Phe Gly Phe Thr Arg Thr Glu Leu Asn 
    690                 695                 700                 


Ser Asn Val Pro Phe Tyr Gly Lys Tyr Glu Ser Glu Glu Ala Pro Ser 
705                 710                 715                 720 


Tyr Glu Thr Leu Met Arg Ile Leu Asp Ala Ile Glu Lys Gly Ser Ile 
                725                 730                 735     


Asn Leu Asp Lys Lys Ile Ala Val Leu Glu Gly Arg Ile Arg Asp His 
            740                 745                 750         


Asn Tyr Ile Lys Ala Phe Glu Lys Asp Gly Leu Ile Lys Asp Gly Lys 
        755                 760                 765             


Leu Thr Glu Leu Gly Arg Glu Leu Leu Glu Val Trp Arg Asn Arg Glu 
    770                 775                 780                 


Phe Asp Ser Ser Asp Val Asp Tyr Ile Arg Asn Leu Ala Glu Asn Leu 
785                 790                 795                 800 


Val Phe Ile Pro Val Glu Asp Ile Glu Glu Phe Glu Tyr Glu Gly Tyr 
                805                 810                 815     


Val Tyr Asp Val Thr Thr Glu Thr His Asn Phe Val Ala Asn Gly Ile 
            820                 825                 830         


Leu Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
        835                 840                 845             


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
    850                 855                 860                 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
865                 870                 875                 880 


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
                885                 890                 895     


Ala Ala Thr Arg 
            900 


<210>  440
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tko_LHR

<400>  440

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ser Gly Asp Ser Lys Ile Leu Thr Gly Lys Gly Pro 
    290                 295                 300                 


Val Glu Ile Gly Arg Leu Asn Ser Asn Met Ile Ala Gly Ile Trp Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Leu Val Arg Phe Glu Glu Pro His Arg Val Glu Tyr 
                325                 330                 335     


Arg Arg Glu Gly Val Lys Ile Arg Thr Arg Leu Gly Phe Glu Ile Lys 
            340                 345                 350         


Ala Thr Lys Glu His Lys Phe Leu Thr Val Asp Glu Asn Gly Glu Leu 
        355                 360                 365             


Arg Trp Val Glu Ala Trp Lys Leu Lys Glu Gly Asn Trp Val Gly Val 
    370                 375                 380                 


Val Arg Arg Leu Pro Ser Pro Asn Val Lys Val Ser Ile Leu Asp Leu 
385                 390                 395                 400 


Leu Pro Pro Asn Ala Tyr Leu Lys Leu Lys Gly Glu Phe Leu Arg Glu 
                405                 410                 415     


Leu Lys Leu Ser Ile Gln Ala Lys Phe Gly Ser Ile Arg Thr Tyr Ala 
            420                 425                 430         


Lys Lys Lys Arg Trp Ser Glu Ser Tyr Leu Val Lys Gln Leu Asn Gly 
        435                 440                 445             


Val Tyr Pro Phe Arg Trp Glu Arg Leu Ser Ala Val Leu Lys Asp Leu 
    450                 455                 460                 


Asp Leu Arg Met Thr Glu Asn Asp Val Glu Arg Ile Thr Ser Asp Lys 
465                 470                 475                 480 


Gly Lys Tyr Ser Leu Pro Ile Glu Phe Thr Pro Ser Met Ala Arg Leu 
                485                 490                 495     


Leu Gly Phe Trp Met Ala Asp Gly Ser Trp Lys Gly Gly Thr Leu Thr 
            500                 505                 510         


Leu Phe Ser Ser Asp Arg Lys Met Leu Glu Lys Tyr Lys Glu Leu Cys 
        515                 520                 525             


Lys Glu Glu Phe Gly Val Val Gly Arg Ile Arg Met Leu Asn Glu Ser 
    530                 535                 540                 


Thr Tyr Ser Leu Glu Ile Ser Phe Asn Leu Leu Pro Ala Ile Phe Lys 
545                 550                 555                 560 


Asn Leu Thr Gly Asn Thr Glu Arg Lys Ser Lys Leu Gly Thr Phe Pro 
                565                 570                 575     


Ser Ile Ile Tyr Ser Leu Pro Glu Glu His Lys Arg Glu Phe Leu Ala 
            580                 585                 590         


Gly Tyr Phe Asp Gly Asp Gly Phe Leu Glu Val Lys Gly Gly Arg Val 
        595                 600                 605             


Tyr Ser Ala Gly Phe Ser Thr Phe Asn Lys Arg Phe Ala Glu Gly Ile 
    610                 615                 620                 


Arg Asp Ile Leu Leu Gln Leu Gly Ile Val Ser Ser Ile Arg Ala Arg 
625                 630                 635                 640 


Glu Tyr Asp Glu Val Gln Lys Phe Lys Gly Arg Val Ile Pro Lys Lys 
                645                 650                 655     


Gly Ala Ser Tyr Thr Val Ser Val Leu Gly Gly Glu Tyr Leu Lys Arg 
            660                 665                 670         


Phe Phe Asp Ala Val Arg Pro Trp Arg Ser Asp Tyr Glu Gly Trp Glu 
        675                 680                 685             


Gly Met Tyr Asn Glu Gly Tyr Ser Asn Ser Asp Val Val Pro Asn Leu 
    690                 695                 700                 


Gly Lys Arg Leu Arg Ser Ile Arg Glu Arg Leu Gly Ile Ser Ala Tyr 
705                 710                 715                 720 


Arg Met Ser Lys Met Gly Phe Tyr Asn Pro Val Arg Val Glu Leu Gly 
                725                 730                 735     


Glu Arg Glu Ile Ser Arg Arg Asn Leu Arg Leu Leu Val Glu Phe Tyr 
            740                 745                 750         


Glu Arg Val Ala Lys Glu Lys Arg Val Glu Asp Val Leu Glu Glu Leu 
        755                 760                 765             


Ser Tyr Leu Arg Glu Leu Ala Glu Gly Asp Val Phe Phe Asp Arg Ile 
    770                 775                 780                 


Thr Ser Val Glu Pro Ala Tyr Ile Asp Val Ala Tyr Gly Ile Ile Asn 
785                 790                 795                 800 


Ser Glu Thr Glu Asn Tyr Ile Val Glu Gly Phe Ile Ser Lys Asn Ser 
                805                 810                 815     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            820                 825                 830         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        835                 840                 845             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    850                 855                 860                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
865                 870                 875                 


<210>  441
<211>  890
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Tko_Pol-2_Pko_Pol-2

<400>  441

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Ile Leu Pro Glu Glu Trp Leu Pro Val Leu Glu Glu Gly 
    290                 295                 300                 


Glu Val His Phe Val Arg Ile Gly Glu Leu Ile Asp Arg Met Met Glu 
305                 310                 315                 320 


Glu Asn Ala Gly Lys Val Lys Arg Glu Gly Glu Thr Glu Val Leu Glu 
                325                 330                 335     


Val Ser Gly Leu Glu Val Pro Ser Phe Asn Arg Arg Thr Asn Lys Ala 
            340                 345                 350         


Glu Leu Lys Arg Val Lys Ala Leu Ile Arg His Asp Tyr Ser Gly Lys 
        355                 360                 365             


Val Tyr Thr Ile Arg Leu Lys Ser Gly Arg Arg Ile Lys Ile Thr Ser 
    370                 375                 380                 


Gly His Ser Leu Phe Ser Val Arg Asn Gly Glu Leu Val Glu Val Thr 
385                 390                 395                 400 


Gly Asp Glu Leu Lys Pro Gly Asp Leu Val Ala Val Pro Arg Arg Leu 
                405                 410                 415     


Glu Leu Pro Glu Arg Asn His Val Leu Asn Leu Val Glu Leu Leu Leu 
            420                 425                 430         


Gly Thr Pro Glu Glu Glu Thr Leu Asp Ile Val Met Thr Ile Pro Val 
        435                 440                 445             


Lys Gly Lys Lys Asn Phe Phe Lys Gly Met Leu Arg Thr Leu Arg Trp 
    450                 455                 460                 


Ile Phe Gly Glu Glu Lys Arg Pro Arg Thr Ala Arg Arg Tyr Leu Arg 
465                 470                 475                 480 


His Leu Glu Asp Leu Gly Tyr Val Arg Leu Lys Lys Ile Gly Tyr Glu 
                485                 490                 495     


Val Leu Asp Trp Asp Ser Leu Lys Asn Tyr Arg Arg Leu Tyr Glu Ala 
            500                 505                 510         


Leu Val Glu Asn Val Arg Tyr Asn Gly Asn Lys Arg Glu Tyr Leu Val 
        515                 520                 525             


Glu Phe Asn Ser Ile Arg Asp Ala Val Gly Ile Met Pro Leu Lys Glu 
    530                 535                 540                 


Leu Lys Glu Trp Lys Ile Gly Thr Leu Asn Gly Phe Arg Met Arg Lys 
545                 550                 555                 560 


Leu Ile Glu Val Asp Glu Ser Leu Ala Lys Leu Leu Gly Tyr Tyr Val 
                565                 570                 575     


Ser Glu Gly Tyr Ala Arg Lys Gln Arg Asn Pro Lys Asn Gly Trp Ser 
            580                 585                 590         


Tyr Ser Val Lys Leu Tyr Asn Glu Asp Pro Glu Val Leu Asp Asp Met 
        595                 600                 605             


Glu Arg Leu Ala Ser Arg Phe Phe Gly Lys Val Arg Arg Gly Arg Asn 
    610                 615                 620                 


Tyr Val Glu Ile Pro Lys Lys Ile Gly Tyr Leu Leu Phe Glu Asn Met 
625                 630                 635                 640 


Cys Gly Val Leu Ala Glu Asn Lys Arg Ile Pro Glu Phe Val Phe Thr 
                645                 650                 655     


Ser Pro Lys Gly Val Arg Leu Ala Phe Leu Glu Gly Tyr Ser Ser Ala 
            660                 665                 670         


Met Ala Thr Ser Thr Glu Gln Glu Thr Gln Ala Leu Asn Glu Lys Arg 
        675                 680                 685             


Ala Leu Ala Asn Gln Leu Val Leu Leu Leu Asn Ser Val Gly Val Ser 
    690                 695                 700                 


Ala Val Lys Leu Gly His Asp Ser Gly Val Tyr Arg Val Tyr Ile Asn 
705                 710                 715                 720 


Glu Glu Leu Pro Phe Val Lys Leu Asp Lys Lys Lys Asn Ala Tyr Tyr 
                725                 730                 735     


Ser His Val Ile Pro Lys Glu Val Leu Ser Glu Val Phe Gly Lys Val 
            740                 745                 750         


Phe Gln Lys Asn Val Ser Pro Gln Thr Phe Arg Lys Met Val Glu Asp 
        755                 760                 765             


Gly Arg Leu Asp Pro Glu Lys Ala Gln Arg Leu Ser Trp Leu Ile Glu 
    770                 775                 780                 


Gly Asp Val Val Leu Asp Arg Val Glu Ser Val Asp Val Glu Asp Tyr 
785                 790                 795                 800 


Asp Gly Tyr Val Tyr Asp Leu Ser Val Glu Asp Asn Glu Asn Phe Leu 
                805                 810                 815     


Val Gly Phe Gly Leu Val Tyr Ala His Asn Ser Thr Tyr Ala Ser Leu 
            820                 825                 830         


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
        835                 840                 845             


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
    850                 855                 860                 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
865                 870                 875                 880 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                885                 890 


<210>  442
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tko_RadA

<400>  442

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Lys Asp Thr Lys Val Tyr Tyr Glu Asn Asp Thr 
    290                 295                 300                 


Leu Val His Phe Glu Ser Ile Glu Asp Met Tyr His Lys Tyr Ala Ser 
305                 310                 315                 320 


Leu Gly Arg Glu Val Pro Phe Asp Asn Gly Tyr Ala Val Pro Leu Glu 
                325                 330                 335     


Thr Val Ser Val Tyr Thr Phe Asp Pro Lys Thr Gly Glu Val Lys Arg 
            340                 345                 350         


Thr Lys Ala Ser Tyr Ile Tyr Arg Glu Lys Val Glu Lys Leu Ala Glu 
        355                 360                 365             


Ile Arg Leu Ser Asn Gly Tyr Leu Leu Arg Ile Thr Leu Leu His Pro 
    370                 375                 380                 


Val Leu Val Phe Arg Asn Gly Leu Gln Trp Val Pro Ala Gly Met Ile 
385                 390                 395                 400 


Lys Pro Gly Asp Leu Ile Val Gly Ile Arg Ser Val Pro Ala Asn Ala 
                405                 410                 415     


Ala Thr Ile Glu Glu Ser Glu Ala Tyr Phe Leu Gly Leu Phe Val Ala 
            420                 425                 430         


Glu Gly Thr Ser Asn Pro Leu Ser Ile Thr Thr Gly Ser Glu Glu Leu 
        435                 440                 445             


Lys Asp Phe Ile Val Ser Phe Ile Glu Asp His Asp Gly Tyr Thr Pro 
    450                 455                 460                 


Thr Val Glu Val Arg Arg Gly Leu Tyr Arg Ile Leu Phe Arg Lys Lys 
465                 470                 475                 480 


Thr Ala Glu Trp Leu Gly Glu Leu Ala Thr Ser Asn Ala Ser Thr Lys 
                485                 490                 495     


Val Val Pro Glu Arg Val Leu Asn Ala Gly Glu Ser Ala Ile Ala Ala 
            500                 505                 510         


Phe Leu Ala Gly Tyr Leu Asp Gly Asp Gly Tyr Leu Thr Glu Ser Ile 
        515                 520                 525             


Val Glu Leu Val Thr Lys Ser Arg Glu Leu Ala Asp Gly Leu Val Phe 
    530                 535                 540                 


Leu Leu Lys Arg Leu Gly Ile Thr Pro Arg Ile Ser Gln Lys Thr Ile 
545                 550                 555                 560 


Glu Gly Ser Val Tyr Tyr Arg Ile Tyr Ile Thr Gly Glu Asp Arg Lys 
                565                 570                 575     


Thr Phe Glu Lys Val Leu Glu Lys Ser Arg Ile Lys Pro Gly Glu Met 
            580                 585                 590         


Asn Glu Gly Gly Val Gly Arg Tyr Pro Pro Ala Leu Gly Lys Phe Leu 
        595                 600                 605             


Gly Lys Leu Tyr Ser Glu Phe Arg Leu Pro Lys Arg Asp Asn Glu Thr 
    610                 615                 620                 


Ala Tyr His Ile Leu Thr Arg Ser Arg Asn Val Trp Phe Thr Glu Lys 
625                 630                 635                 640 


Thr Leu Ser Arg Ile Glu Glu Tyr Phe Arg Glu Ala Leu Glu Lys Leu 
                645                 650                 655     


Ser Glu Ala Arg Lys Ala Leu Glu Met Gly Asp Lys Pro Glu Leu Pro 
            660                 665                 670         


Phe Pro Trp Thr Ala Ile Thr Lys Tyr Gly Phe Thr Asp Arg Gln Val 
        675                 680                 685             


Ala Asn Tyr Arg Thr Arg Gly Leu Pro Lys Arg Pro Glu Leu Lys Glu 
    690                 695                 700                 


Lys Val Val Ser Ala Leu Leu Lys Glu Ile Glu Arg Leu Glu Gly Val 
705                 710                 715                 720 


Ala Lys Leu Ala Leu Glu Thr Ile Glu Leu Ala Arg Arg Leu Glu Phe 
                725                 730                 735     


His Glu Val Ser Ser Val Glu Val Val Asp Tyr Asn Asp Trp Val Tyr 
            740                 745                 750         


Asp Leu Val Ile Pro Glu Thr His Asn Phe Ile Ala Pro Asn Gly Leu 
        755                 760                 765             


Val Leu His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
    770                 775                 780                 


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
785                 790                 795                 800 


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
                805                 810                 815     


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
            820                 825                 830         


Ala Ala Thr Arg 
        835     


<210>  443
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tko_r-Gyr

<400>  443

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Pro Asp Thr Leu Val Ser Leu Ala Asp Gly Arg 
    290                 295                 300                 


Ile Met Glu Ile Lys Asp Ala Val Glu Lys Ser Glu Gly Asn Leu Leu 
305                 310                 315                 320 


Ser Val Asn Gly Leu Lys Pro Lys Glu Ala Lys Ala Leu Lys Phe Trp 
                325                 330                 335     


Glu Ile Asp Trp Asn Gly Pro Leu Lys Val Ile Lys Leu Lys Asn Gly 
            340                 345                 350         


His Glu Ile Lys Ala Thr Pro Asp His Gly Leu Leu Val Met Arg Glu 
        355                 360                 365             


Gly Lys Leu Gly Trp Val Ser Ala Lys Asn Val Arg Glu Gly Asp Tyr 
    370                 375                 380                 


Val Ala Phe Ala Tyr Asn Thr Gly His Arg Gly Arg Asp Glu Tyr Thr 
385                 390                 395                 400 


Leu Leu Lys Leu Met Ile Lys Leu Gly Ile Thr Asp Val Met Val Glu 
                405                 410                 415     


Leu Asp Glu Glu Tyr Phe Asn Glu Lys Val Ala Pro Ile Val Arg Glu 
            420                 425                 430         


Arg Ile Ser Thr Ser Thr Lys Tyr Lys Tyr Leu Arg Arg Arg Val Leu 
        435                 440                 445             


Pro Leu Tyr Leu Leu Gln Glu Trp Gly Leu Asp Asp Tyr Glu Ala His 
    450                 455                 460                 


Val Lys Ser Leu Tyr Arg Gln Arg Ala Gly Ser Lys Pro Ile Pro Asn 
465                 470                 475                 480 


Phe Lys Leu Asp Gly Arg Phe Trp Tyr Val Phe Gly Leu Val Leu Gly 
                485                 490                 495     


Asp Gly Thr Leu Arg Asp Ser Lys Val Leu Ile Ser Gln Thr Pro Leu 
            500                 505                 510         


Lys Asp Val Lys Ser Val Leu Glu Asp Val Phe Pro Phe Leu Arg Val 
        515                 520                 525             


Phe Glu Thr Thr Asn Gln Val Gly Phe Ser Asn Ser Ile Ile Ala Glu 
    530                 535                 540                 


Val Phe Arg Arg Leu Gly Ala Arg Lys Gly Lys Leu His Pro Leu Val 
545                 550                 555                 560 


Phe Gly Leu Arg Glu Glu Tyr Ile Asn Ala Met Ile Ala Gly Tyr Phe 
                565                 570                 575     


Asp Thr Asp Gly Thr Phe Ser Ile Leu Asn Asp Arg Lys Gly Pro Asn 
            580                 585                 590         


Phe Arg Gly Ile Leu Thr Ser Lys Arg Gly Asp Val Leu Arg Met Leu 
        595                 600                 605             


Ser Val Tyr Leu Tyr Gln Ile Gly Ile Met Asn Tyr Leu Arg Arg Asp 
    610                 615                 620                 


Glu Arg Thr Gly Val Trp Asp Leu Ile Ile Ser Asn Arg Ser Leu Glu 
625                 630                 635                 640 


Lys Phe Arg Glu Lys Ile Tyr Pro Tyr Leu Arg Ile Arg Arg Ala Gln 
                645                 650                 655     


Phe Asp Glu Ala Tyr Ser Val Tyr Arg Ala Ser Arg Arg Ala Phe Glu 
            660                 665                 670         


Gly Asp Leu Leu Pro Val Ala Pro Val Phe Gly Lys Leu Lys Phe Lys 
        675                 680                 685             


Asn Gly Thr Lys Asn Arg Ile Leu Lys Glu Thr Gly Ile Asp Val Trp 
    690                 695                 700                 


Asn Trp Leu Lys Arg Pro Glu Gly Glu Ile Pro Arg Asp Lys Leu Ser 
705                 710                 715                 720 


Lys Val Leu Glu Tyr Ala Glu Glu Ser Pro Glu Lys Glu Phe Leu Lys 
                725                 730                 735     


Ser Leu Val Glu Ala Gly Val Thr Trp Val Lys Val Lys Gly Val Glu 
            740                 745                 750         


Glu Glu Leu Tyr Thr Gly Lys Leu Tyr Asp Phe Thr Thr Thr Thr Glu 
        755                 760                 765             


Asn Phe Leu Ser Asn Gly Ala Val Ser His Asn Ser Thr Tyr Ala Ser 
    770                 775                 780                 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
785                 790                 795                 800 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
                805                 810                 815     


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
            820                 825                 830         


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        835                 840             


<210>  444
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tko_RIR1-1

<400>  444

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Ile Asp Gly Asn Ala Lys Ile Ile Phe Glu Asn Asp Gly 
    290                 295                 300                 


Glu Glu His Ile Met Thr Met Ala Glu Met Tyr Glu Arg Tyr Lys Asp 
305                 310                 315                 320 


Leu Gly Glu Phe Tyr Asp Pro Glu Tyr Asn Arg Trp Gly Ile Asn Val 
                325                 330                 335     


Glu Glu Val Pro Val Tyr Val Lys Ser Phe Asp Pro Ser Thr Lys Glu 
            340                 345                 350         


Ile Thr Lys Gly Lys Val Lys Val Ile Trp Lys Tyr Glu Leu Gly Glu 
        355                 360                 365             


Asp Val Pro Lys Tyr Glu Ile Lys Thr Asn Lys Gly Thr Arg Val Leu 
    370                 375                 380                 


Thr Ser Pro Trp His Pro Phe Phe Val Ile Thr Gln Asp Leu Lys Ile 
385                 390                 395                 400 


Val Glu Lys Arg Ala Asp Glu Leu Arg Glu Gly Asp Met Leu Val Gly 
                405                 410                 415     


Gly Met Pro Ser Asp Asp Asp Tyr Glu Phe Leu Leu Asp Tyr Trp Leu 
            420                 425                 430         


Ala Gly Phe Ile Ala Gly Asp Gly Ser Ile Asp Lys Tyr Arg Ser His 
        435                 440                 445             


Val Lys Gly His Glu Tyr Val Tyr Asp Arg Leu Arg Ile Tyr Asp Tyr 
    450                 455                 460                 


Thr Thr Glu Thr Leu Gly Ile Ile Asn Asp His Leu Glu Lys Thr Phe 
465                 470                 475                 480 


Gly Lys Arg Tyr Ser Leu Gln Arg Asp Arg Asn Ile His Tyr Ile Asp 
                485                 490                 495     


Ile Lys Ala Lys Gly Ile Thr Ser His Tyr Ile Glu Leu Leu Arg Gly 
            500                 505                 510         


Ile Thr Asn Gly Ile Pro Gln Pro Ile Leu Lys Glu Gly Arg Asn Ala 
        515                 520                 525             


Val Leu Ser Phe Ile Thr Gly Leu Phe Asp Ala Glu Gly His Val Asn 
    530                 535                 540                 


Ser Lys Pro Gly Val Glu Leu Gly Met Val Asn Arg Lys Leu Ile Glu 
545                 550                 555                 560 


Asp Ile Thr Tyr Tyr Leu Asn Ser Leu Gly Ile Lys Ala Arg Met Arg 
                565                 570                 575     


Lys Lys Pro Arg Lys Asp Gly Val Asp Tyr Val Met His Val Glu Glu 
            580                 585                 590         


Tyr Ser Ser Leu Leu Arg Phe Tyr Glu Leu Ile Gly Lys Asn Leu Gln 
        595                 600                 605             


Asn Ser Glu Lys Arg Ile Lys Leu Glu Glu Leu Leu Ser Lys His Asn 
    610                 615                 620                 


Gly Gly Ser Phe Gly Leu Thr Leu Ser Phe Glu Asp Phe Lys Ala Trp 
625                 630                 635                 640 


Ser Ser Lys Tyr Gly Val Glu Phe Lys Thr Asn Gly Ser Gln Thr Leu 
                645                 650                 655     


Ala Ile Ile Lys Asn Glu Lys Val Ser Leu Gly Gln Trp His Arg Arg 
            660                 665                 670         


Gly Arg Val Ser Lys Ala Val Leu Val Lys Met Leu Arg Lys Leu Tyr 
        675                 680                 685             


Asp Thr Thr Lys Ser Glu Asp Val Lys Arg Met Leu His Leu Ile Glu 
    690                 695                 700                 


Gly Leu Glu Val Val Lys Glu Ile Asn Val Thr Asn Glu Pro Lys Thr 
705                 710                 715                 720 


Phe Tyr Asp Leu Thr Val Glu Arg Tyr Gln Asn Tyr Leu Ala Gly Glu 
                725                 730                 735     


Asn Gly Met Val Phe Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
            740                 745                 750         


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
        755                 760                 765             


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
    770                 775                 780                 


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
785                 790                 795                 800 


Val Asn Ala Glu Ala Ala Thr Arg 
                805             


<210>  445
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tko_TopA

<400>  445

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu His Pro Asp Ser Leu Ile Pro Thr Pro Gln Gly Val 
    290                 295                 300                 


Lys Arg Ile Lys Glu Leu Pro Glu Lys Gly Glu Val Phe Ala Leu Asp 
305                 310                 315                 320 


Phe Asp Leu Lys Leu Ser Arg Ala Arg Tyr Arg Leu Leu Glu Arg Asp 
                325                 330                 335     


Ala Asp Glu Pro Met Tyr Lys Val Thr Leu Ser Asp Arg Thr Glu Leu 
            340                 345                 350         


Tyr Leu Thr Ala Asp His Pro Val Leu Val Tyr Arg Asp Asp Gln Leu 
        355                 360                 365             


Ile Phe Val Pro Ala Glu Glu Leu Arg Glu Asn Asp Gln Val Val Leu 
    370                 375                 380                 


Phe Ile Asn Arg Ser Glu Tyr Ser Pro Arg Thr Glu Ser Pro Thr Leu 
385                 390                 395                 400 


Leu Gly Phe Leu Leu Glu Asn Ala Thr Ser Met Lys Asp Tyr Ile Leu 
                405                 410                 415     


Tyr Asp Pro Glu Phe Gly Gly Val Leu Arg Asn Arg Ile Lys Asp Ala 
            420                 425                 430         


Gly Leu Lys Thr Glu Ile Leu Trp Arg Phe Arg Ile Arg Glu Pro Thr 
        435                 440                 445             


Tyr Tyr Lys Tyr Leu Arg Gly Lys Met Pro Val Pro Ile Val Arg Phe 
    450                 455                 460                 


Leu Leu Glu Glu Gly Val Val Ser Ile Glu Glu Leu Arg Glu Val Phe 
465                 470                 475                 480 


Arg Gly Phe Ser Tyr Ser Thr Ser Leu Thr Pro Ile Ser Phe Glu Phe 
                485                 490                 495     


Ser Glu Glu Phe Trp Tyr Leu Phe Gly Leu Val Ala Gly Asp Gly His 
            500                 505                 510         


Leu Ala Lys Lys Gly Ala Ile Thr Ile Pro Ala Lys Asp Arg Thr Glu 
        515                 520                 525             


Asp Thr Val Lys Ala Val Lys Glu Ile Ala Asn Ser Leu Gln Val Pro 
    530                 535                 540                 


Phe Ala Phe Asp Glu Lys Tyr Lys Met Ile Ile Leu Arg Ser Lys Ser 
545                 550                 555                 560 


Leu Thr Arg Leu Phe Glu Leu Leu Gly Cys Pro Tyr Gly Asn Lys Thr 
                565                 570                 575     


Glu Ile Phe Arg Ile Pro Gly Glu Ile Met Ala Lys Pro Glu Trp Met 
            580                 585                 590         


Ala Ala Phe Leu Ala Gly Tyr Tyr Asp Ala Asp Gly His Ile Gly Thr 
        595                 600                 605             


Lys Pro Thr Gly Gly Lys Lys Ser His Ser Pro Gln Ile Val Leu Thr 
    610                 615                 620                 


Ser Lys Asn Arg Met Ala Ile Tyr Thr Val Lys Gln Met Trp Gln Leu 
625                 630                 635                 640 


Leu Gly Val Gly Thr Tyr Leu Trp Glu Lys Lys Asp Arg Asn Gly Asn 
                645                 650                 655     


Phe Met Ala Tyr Glu Leu Lys Val Tyr Ser Arg Asp Ala Trp Arg Phe 
            660                 665                 670         


Tyr Glu Val Met Lys Asn His Leu Arg Ile Lys Arg Lys Asp Leu Glu 
        675                 680                 685             


His Val Lys Glu Val Ala Ile Arg Lys Arg Lys Ala Tyr Ser His His 
    690                 695                 700                 


Tyr Ser Val Leu Asn Val Lys Ser Trp Glu Gly Lys Ile Lys Ser Ser 
705                 710                 715                 720 


Asn Val Leu Trp Lys Lys Phe Asp Met Ser Asn Gln Thr Ala His Gly 
                725                 730                 735     


Arg Gly Ile Ser Leu Asp Lys Leu Gln Arg Ile Val Asp Tyr Leu Thr 
            740                 745                 750         


Asp Thr Asp Leu Arg Arg Ile Ala Met Gly Asp Val Tyr Val Leu Gly 
        755                 760                 765             


Ile Arg Ser Ile Glu Lys Phe His Tyr Arg Gly Lys Val Tyr Asp Leu 
    770                 775                 780                 


Val Val Asp Gln Tyr His Asn Phe Ile Ala Asn Gly Val Val Val His 
785                 790                 795                 800 


Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His 
                805                 810                 815     


Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser 
            820                 825                 830         


Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly 
        835                 840                 845             


Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr 
    850                 855                 860                 


Arg 
865 


<210>  446
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Tth-HB27_DnaE-2

<400>  446

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Pro Ala Arg Ala Arg Val Val Asp Trp Cys Thr Gly 
    290                 295                 300                 


Arg Val Val Arg Val Gly Glu Ile Val Arg Gly Glu Ala Lys Gly Val 
305                 310                 315                 320 


Trp Val Val Ser Leu Asp Glu Ala Arg Leu Arg Leu Val Pro Arg Pro 
                325                 330                 335     


Val Val Ala Ala Phe Pro Ser Gly Lys Ala Gln Val Tyr Ala Leu Arg 
            340                 345                 350         


Thr Ala Thr Gly Arg Val Leu Glu Ala Thr Ala Asn His Pro Val Tyr 
        355                 360                 365             


Thr Pro Glu Gly Trp Arg Pro Leu Gly Thr Leu Ala Pro Gly Asp Tyr 
    370                 375                 380                 


Val Ala Leu Pro Arg His Leu Ser Tyr Arg Pro Ser Leu His Leu Glu 
385                 390                 395                 400 


Gly His Glu Leu Asp Leu Leu Gly Phe Ala Leu Ala Glu Gly His Leu 
                405                 410                 415     


Arg His Pro Ser Gly Val Tyr Leu Tyr Thr Ser Ser Glu Glu Glu Leu 
            420                 425                 430         


Ala Ala Met Glu Glu Ala Leu Arg Ala Phe Pro Asn Thr Arg Ile Arg 
        435                 440                 445             


Val Val Trp Arg Arg Gly Val Ala His Val Tyr Val Gly Arg Val Asp 
    450                 455                 460                 


Arg Arg Gln Glu Ala Gly Ala Val Ala Phe Leu Arg Arg Met Gly Leu 
465                 470                 475                 480 


Leu Gly Leu Asp Ala Lys Thr Lys Arg Leu Pro Glu Ala Val Phe Gly 
                485                 490                 495     


Leu Pro Pro Glu Glu Val Ala Arg Phe Leu Gly Arg Leu Trp Thr Gly 
            500                 505                 510         


Asp Gly Gly Val Asp Pro Lys Gly Arg Leu Ile His Tyr Ala Thr Ala 
        515                 520                 525             


Ser Lys Glu Leu Ala Trp Gly Val Gln His Leu Leu Leu Arg Leu Gly 
    530                 535                 540                 


Leu Gln Ser Arg Leu Val Glu Lys Arg Phe Ser Gly Gly Tyr Lys Gly 
545                 550                 555                 560 


Tyr Ala Val Tyr Leu Leu Gly Gly Leu Glu Ala Ala Arg Arg Phe Ala 
                565                 570                 575     


Glu Thr Val Gly Pro Tyr Leu Val Gly Lys Arg Arg Gln Asp Leu Glu 
            580                 585                 590         


Ala Leu Leu Ala Ser Trp Glu Lys Ala Gly Arg Ser Thr Gly Asp Val 
        595                 600                 605             


Leu Pro Leu Ala Phe Leu Glu Glu Val Arg Ala Ala Val Ala Glu Val 
    610                 615                 620                 


Ala Gln Gly Gln Val Ala Asp Leu Leu Arg Glu Ala Gly Leu Ala Glu 
625                 630                 635                 640 


Gly Leu Leu Cys Leu Gly Arg Gly Arg Arg Gly Leu Ser Arg Ala Thr 
                645                 650                 655     


Val Gly Arg Leu Ala Ala Leu Thr Gly Ser Leu Ala Leu Leu Arg Leu 
            660                 665                 670         


Ala Glu Ala Glu Val Tyr Trp Asp Arg Val Glu Ala Val Glu Pro Leu 
        675                 680                 685             


Gly Glu Glu Glu Val Phe Asp Leu Thr Val Glu Gly Thr His Thr Phe 
    690                 695                 700                 


Val Ala Glu Asp Val Ile Val His Asn Ser Thr Tyr Ala Ser Leu Asn 
705                 710                 715                 720 


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
                725                 730                 735     


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
            740                 745                 750         


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
        755                 760                 765             


Leu Val Asn Ala Glu Ala Ala Thr Arg 
    770                 775         


<210>  447
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Tth-HB27_RIR1-1

<400>  447

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu His Pro Asp Thr Leu Val His Thr Asp Arg Gly Thr 
    290                 295                 300                 


Leu Arg Leu Arg Glu Leu Val Asp Pro Phe Arg Arg Gly Trp Gln Pro 
305                 310                 315                 320 


His Thr Leu Ser Val Ala Thr Asp Glu Gly Trp Arg Pro Ser Pro Glu 
                325                 330                 335     


Gly Tyr Asn Asn Gly Val Ala Pro Thr Leu Arg Val Val Leu Glu Asn 
            340                 345                 350         


Gly Leu Glu Val Gln Gly Thr Leu Asn His Lys Leu Lys Val Leu Arg 
        355                 360                 365             


Glu Asp Gly Thr Arg Glu Trp Val Glu Leu Gln Asp Leu Arg Pro Gly 
    370                 375                 380                 


Asp Trp Val Ile Trp Val Leu Asp Glu His Thr Gly Thr Pro Val Gln 
385                 390                 395                 400 


Leu Ala Pro Leu Asp Glu Pro Leu His Pro Asn Thr Thr Pro Ile Arg 
                405                 410                 415     


Thr Pro Glu Val Leu Thr Glu Asp Leu Ala Phe Leu Leu Gly Phe Phe 
            420                 425                 430         


Phe Gly Glu Gly Phe Val Ser Gly Asp Arg Ile Gly Phe Ser Val His 
        435                 440                 445             


Glu Glu Glu Pro Met Arg Glu Glu Ala Lys Arg Leu Phe Arg Glu Leu 
    450                 455                 460                 


Phe Gly Leu Glu Leu Arg Glu Glu Arg Lys Pro Gly Asp Arg Ser Val 
465                 470                 475                 480 


Thr Leu Val Val Arg Ser Arg Pro Leu Val Thr Trp Leu Arg Lys Asn 
                485                 490                 495     


Gly Leu Leu Lys Gly Lys Ala Arg Glu Leu Glu Val Pro Arg Ala Ile 
            500                 505                 510         


Arg Gln Ser Pro Arg Pro Val Leu Ala Ala Phe Leu Arg Gly Leu Phe 
        515                 520                 525             


Glu Ala Asp Gly Thr Ile Thr Ala Gly Tyr Pro Met Leu Thr Thr Ala 
    530                 535                 540                 


Ser Lys Arg Leu Ala Gln Asp Val Met Val Leu Leu Gly Gly Leu Gly 
545                 550                 555                 560 


Ile Pro Ser Lys Leu Leu Arg Tyr Asn Pro Leu Pro Gly Arg Phe Ser 
                565                 570                 575     


Lys Ala Glu His Tyr Gly Val Arg Val Val Thr Ala Lys Gly Leu Glu 
            580                 585                 590         


Arg Tyr Leu Glu Arg Ile Gly Val Pro Lys Gly Ser Arg Leu Glu Ala 
        595                 600                 605             


Leu His Gly Ile Lys Pro Asp Val Arg Arg Glu Ser Ser Trp Pro Leu 
    610                 615                 620                 


Pro His Ala Glu Gly Leu Leu Lys Pro Leu Leu Thr Val Thr Glu Lys 
625                 630                 635                 640 


Gly Arg Lys Gly Tyr Ala Ser Pro Tyr Thr Pro Leu Arg Lys Asp Leu 
                645                 650                 655     


Leu Arg Tyr Leu Arg Gly Glu Arg Gln Leu Thr Ala Thr Gly Tyr Ala 
            660                 665                 670         


Met Val Leu Glu Lys Ala Gln Asp Leu Gly Leu Glu Ala Glu Pro Phe 
        675                 680                 685             


Pro Phe Asn Glu Tyr Tyr Val Arg Val Ala Ser Val Glu Pro Gly Gly 
    690                 695                 700                 


Glu Ile Leu Thr Leu Asp Leu Ser Val Glu Gly Asn His Thr Tyr Leu 
705                 710                 715                 720 


Ala Asn Gly Leu Val Ser His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
                725                 730                 735     


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            740                 745                 750         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        755                 760                 765             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    770                 775                 780                 


Val Asn Ala Glu Ala Ala Thr Arg 
785                 790         


<210>  448
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Tth-HB27_RIR1-2

<400>  448

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Val Gly Ser Thr Arg Ile Pro Thr Glu Arg Gly Leu 
    290                 295                 300                 


Val Pro Ile Glu Glu Leu Ala Arg Glu Gly Gly Ser Phe Tyr Leu Val 
305                 310                 315                 320 


Thr Asp Asn Arg Ala Pro Phe Gly Gly Arg Gly Ala Pro Leu Pro Gly 
                325                 330                 335     


His Gly Thr Ala Val Arg Lys Ala Val Arg Ala Phe Phe Thr Gly Val 
            340                 345                 350         


Lys Pro Val Val Arg Leu Arg Thr Arg Glu Gly Leu Glu Val Thr Leu 
        355                 360                 365             


Thr Pro Asp His Leu Leu Leu Thr Pro Glu Gly Tyr Arg Glu Ala Gly 
    370                 375                 380                 


Lys Leu Arg Pro Gly Glu Lys Ile Leu Val Gln Ser Gly Glu Gly Leu 
385                 390                 395                 400 


Phe Pro Lys Glu Glu Ser Leu Pro Ala Gln Ala Leu Ala Val Val His 
                405                 410                 415     


Glu Arg Val Ala Thr Ala Gly Gly Arg Gly Gly Arg Gly Arg Ala Asp 
            420                 425                 430         


Val Arg Ala Gln Tyr Arg Asn Leu Pro Thr Arg Trp Ser Arg Glu Leu 
        435                 440                 445             


Gly Val Ala Leu Gly Trp Leu Leu Gly Asp Gly Tyr Leu Arg Glu Asp 
    450                 455                 460                 


Gly Val Gly Phe Tyr Phe Ser Arg Lys Asp Phe Ala Asp Leu Ala Trp 
465                 470                 475                 480 


Leu Pro Asp Leu Leu Arg Asp Trp Phe Gly Pro Gly Thr Leu Gln Glu 
                485                 490                 495     


Thr Arg Ser Asn Thr Phe His Leu His Phe Asn Arg Ile Pro Ala Glu 
            500                 505                 510         


Phe Phe Gln Ala Leu Gly Val Lys Ala Ala Arg Ala Thr Glu Lys Arg 
        515                 520                 525             


Val Pro Glu Ser Leu Phe Arg Ala Pro Arg Glu Ala Val Val Gly Phe 
    530                 535                 540                 


Leu Gln Gly Leu Phe Ser Ala Asp Gly Ser Val Gln Ile Asn Glu Asn 
545                 550                 555                 560 


Lys Gln Asp Ala Thr Val Arg Leu Ala Ser Ser Ser Leu Ala Leu Leu 
                565                 570                 575     


Gln Asp Val Gln Leu Leu Leu Leu Asn Leu Gly Ile Leu Gly Lys Ile 
            580                 585                 590         


His Lys Arg Arg Glu Ala Ala Arg Lys Ala Leu Pro Asp Gly Lys Gly 
        595                 600                 605             


Gly Leu Arg Glu Tyr Pro Val Ala Pro Gln Tyr Glu Leu Ile Leu Gly 
    610                 615                 620                 


Gly Glu Asn Arg Asp Arg Phe Ala Glu Val Val Gly Phe Leu Gln Glu 
625                 630                 635                 640 


Glu Lys Gln Ser Lys Leu Leu Ala Phe Leu Arg His Arg Pro Arg Gly 
                645                 650                 655     


Ser Tyr Arg Lys Pro Phe Leu Ala Thr Val Ala Ser Val Glu Pro Ala 
            660                 665                 670         


Gly Glu Ala Pro Val Tyr Asp Leu Thr Glu Pro Val Thr His Ser Leu 
        675                 680                 685             


Ile Ala Asn Gly Leu Val Ala His Asn Ser Thr Tyr Ala Ser Leu Asn 
    690                 695                 700                 


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val 
705                 710                 715                 720 


Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu 
                725                 730                 735     


Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly 
            740                 745                 750         


Leu Val Asn Ala Glu Ala Ala Thr Arg 
        755                 760     


<210>  449
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tvo_VMA

<400>  449

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Ser Gly Glu Thr Pro Val Tyr Leu Ala Asp Gly Lys 
    290                 295                 300                 


Thr Ile Lys Ile Lys Asp Leu Tyr Ser Ser Glu Arg Lys Lys Glu Asp 
305                 310                 315                 320 


Asn Ile Val Glu Ala Gly Ser Gly Glu Glu Ile Ile His Leu Lys Asp 
                325                 330                 335     


Pro Ile Gln Ile Tyr Ser Tyr Val Asp Gly Thr Ile Val Arg Ser Arg 
            340                 345                 350         


Ser Arg Leu Leu Tyr Lys Gly Lys Ser Ser Tyr Leu Val Arg Ile Glu 
        355                 360                 365             


Thr Ile Gly Gly Arg Ser Val Ser Val Thr Pro Val His Lys Leu Phe 
    370                 375                 380                 


Val Leu Thr Glu Lys Gly Ile Glu Glu Val Met Ala Ser Asn Leu Lys 
385                 390                 395                 400 


Val Gly Asp Met Ile Ala Ala Val Ala Glu Ser Glu Ser Glu Ala Arg 
                405                 410                 415     


Asp Cys Gly Met Ser Glu Glu Cys Val Met Glu Ala Glu Val Tyr Thr 
            420                 425                 430         


Ser Leu Glu Ala Thr Phe Asp Arg Val Lys Ser Ile Ala Tyr Glu Lys 
        435                 440                 445             


Gly Asp Phe Asp Val Tyr Asp Leu Ser Val Pro Glu Tyr Gly Arg Asn 
    450                 455                 460                 


Phe Ile Gly Gly Glu Gly Leu Leu Val Leu His Asn Ser Thr Tyr Ala 
465                 470                 475                 480 


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
                485                 490                 495     


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
            500                 505                 510         


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
        515                 520                 525             


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
    530                 535                 540 


<210>  450
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Tvu_DnaE-n_NC-terminal

<400>  450

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ser Gly Glu Thr Ala Val Met Thr Val Glu Tyr Gly 
    290                 295                 300                 


Ala Ile Pro Ile Arg Arg Leu Val Gln Glu Arg Leu Ile Cys Gln Val 
305                 310                 315                 320 


Tyr Ser Leu Asp Pro Gln Gly His Leu Tyr Thr Gln Pro Ile Ala Gln 
                325                 330                 335     


Trp His Phe Gln Gly Phe Arg Pro Val Tyr Ala Tyr Gln Leu Glu Asp 
            340                 345                 350         


Gly Ser Thr Ile Cys Ala Thr Pro Asp His Arg Phe Met Thr Thr Ser 
        355                 360                 365             


Gly Gln Met Leu Pro Ile Glu Gln Ile Phe Arg Glu Gly Leu Glu Leu 
    370                 375                 380                 


Trp Gln Val Ala Ile Ala Pro Pro Gly Ala Leu Ala Gln Gly Leu Lys 
385                 390                 395                 400 


Pro Ala Val Gln Met Ser Cys Met Lys Ile Val Gly Arg Arg Leu Val 
                405                 410                 415     


Gly Trp Gln Ala Val Tyr Asp Ile Gly Leu Ala Gly Asp His Asn Phe 
            420                 425                 430         


Leu Leu Ala Asn Gly Ala Ile Ala Ala Asn Ser Thr Tyr Ala Ser Leu 
        435                 440                 445             


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
    450                 455                 460                 


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
465                 470                 475                 480 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
                485                 490                 495     


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            500                 505     


<210>  451
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Unc-ERS_RIR1

<400>  451

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Val Thr Ala Asp Thr Trp Val Thr Thr Ala Glu Gly Pro 
    290                 295                 300                 


Arg Gln Val Glu Glu Leu Ile Gly Lys Lys Phe Thr Ala Ile Val Asn 
305                 310                 315                 320 


Gly Glu Glu Trp Glu Ser Ser Glu Glu Gly Phe Phe Glu Thr Asp Val 
                325                 330                 335     


Lys Pro Val Tyr Thr Leu Lys Thr Ala Glu Gly Phe Glu Leu Arg Leu 
            340                 345                 350         


Thr Ala Asp His Pro Val Met Lys Val Glu Arg Met Thr Arg Tyr Lys 
        355                 360                 365             


Val Glu Thr Gln Trp Ser Asn Ala Gly Asp Leu Lys Pro Gly Asp Lys 
    370                 375                 380                 


Ile Ile Ile Asn Asn His Arg Asp Phe Gly Asn Trp Ser Val Lys Gly 
385                 390                 395                 400 


Lys Tyr Thr Glu Gly Glu Gly Tyr Leu Ile Gly Leu Leu Leu Gly Asp 
                405                 410                 415     


Gly Thr Ile Lys Lys Leu Asn Pro Trp Met Lys Ala Ile Ser Lys Lys 
            420                 425                 430         


Met Glu Lys Ala Ser Ala Asp Phe Cys Glu Gly Ile Leu Arg Gly Leu 
        435                 440                 445             


Phe Asp Ala Asp Gly Ser Val Gln Gly Asn Gln Ser Lys Gly Val Ser 
    450                 455                 460                 


Ile Arg Leu Ala Gln Ser Asp Val Glu Ile Leu Lys Ala Val Gln Arg 
465                 470                 475                 480 


Ile Leu Leu Arg Phe Gly Ile Phe Ser Lys Val Tyr Met Asn Arg Arg 
                485                 490                 495     


Gly Glu Arg Lys Val Lys Met Pro Asp Gly Lys Gly Gly Val Lys Glu 
            500                 505                 510         


Tyr Ile Thr Lys Pro Gln His Glu Leu Val Ile Ser Asn Asp Asn Ile 
        515                 520                 525             


Leu Tyr Phe Ala Glu Arg Val Gly Phe Ser Asp Ala Glu Lys Met Glu 
    530                 535                 540                 


Lys Leu Glu Lys Ala Ile Trp Asn Tyr Lys Arg Lys Met Asn Arg Glu 
545                 550                 555                 560 


Arg Phe Val Ala Ser Val Glu Glu Val Val Pro Asp Gly Val Glu Lys 
                565                 570                 575     


Val Tyr Asp Val Lys Ile Pro Gly Ile Asn Ala Phe Asn Ala Asn Gly 
            580                 585                 590         


Phe Val Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
        595                 600                 605             


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
    610                 615                 620                 


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
625                 630                 635                 640 


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
                645                 650                 655     


Glu Ala Ala Thr Arg 
            660     


<210>  452
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Zba_VMA

<400>  452

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Lys Gly Thr Glu Val Met Met His Asp Gly Ser 
    290                 295                 300                 


Val Lys Ala Ile Glu Thr Ile Glu Ala Gly Glu Ala Val Met Gly Thr 
305                 310                 315                 320 


Asp Gly Gln Pro Arg Lys Val Val Gly Leu Pro Arg Gly Arg Glu Val 
                325                 330                 335     


Met Tyr Lys Val Ser Gln Lys Thr Ala His Arg Val His Lys Thr Asp 
            340                 345                 350         


Glu Thr Arg Ala Ala Pro Val Ala Leu Phe Glu Tyr Asn Cys Asn Ala 
        355                 360                 365             


Thr His Lys Leu Val Val Arg Thr Pro Arg Ser Cys Arg Ser Ile Thr 
    370                 375                 380                 


Arg Lys Met Gln Gly Val Asp Tyr Asn Glu Val Ile Phe Phe Asp Leu 
385                 390                 395                 400 


Lys Lys Lys Lys Leu Glu Asp Gly Arg Glu Ile Glu Ile Val Lys Glu 
                405                 410                 415     


Val Ser Arg Ser Tyr Pro Ala Ala Glu Gly Ala Glu Lys Ala Ala Gln 
            420                 425                 430         


Met Val Lys Asp Tyr Tyr Asp Ala Ala Arg Gly Lys Glu Phe Phe Glu 
        435                 440                 445             


Trp Thr Ile Glu Ala Arg Asp Val Arg Glu Leu Gly Ala His Val Arg 
    450                 455                 460                 


Lys Ala Thr His Gln Val Tyr Ala Pro Val Leu Tyr Glu Ser Asp Phe 
465                 470                 475                 480 


Phe Phe His Tyr Val Lys Asn Ser Lys Phe Ala Leu Arg Ser Glu Ala 
                485                 490                 495     


Ser Thr Ala Leu Ala Tyr Leu Leu Gly Leu Trp Val Gly Asp Gly Leu 
            500                 505                 510         


Ser Asp Arg Ala Val Leu Ser Val Asp Ser Glu Asp Ser Ser Leu Leu 
        515                 520                 525             


Glu Arg Ile Thr Gly Tyr Ala Asp Ile Leu Asp Leu Ser Ala Glu Tyr 
    530                 535                 540                 


Lys Asp Arg Glu Ile Pro Lys Arg Ala Lys Thr Val Cys Leu Tyr Pro 
545                 550                 555                 560 


Lys Thr Ile Arg Gly Asn Asp Ile Arg Arg Asn Leu Asn Thr Asp Asn 
                565                 570                 575     


Pro Val Trp Asn Ala Ile Val Asp Leu Gly Tyr Leu Lys Asp Gly Val 
            580                 585                 590         


Lys Asn Val Pro Ser Tyr Leu Phe Ser Asp Ser Ile Cys His Arg Glu 
        595                 600                 605             


Val Phe Leu Ala Gly Leu Ile Asp Ser Asp Gly His Val Arg Gly Asp 
    610                 615                 620                 


Asp Gly Leu Ser Val Thr Ile Lys Thr Ile His Lys Thr Val Met Glu 
625                 630                 635                 640 


Gly Thr Val Ala Val Ala Arg Ser Leu Gly Leu Ile Val Ser Val Asn 
                645                 650                 655     


Thr Glu Glu Ala Lys Ile Asp Lys Asn Asp Val Asn His Arg Phe Val 
            660                 665                 670         


Tyr Ala Ile Tyr Ile Ser Gly Gly Asp Ala Leu Leu Ser Val Leu Ala 
        675                 680                 685             


His Cys Ala Ala Ala Lys Lys Phe Arg Ala Pro Pro Ser Asn Glu Val 
    690                 695                 700                 


Val Arg Gly Leu Lys Lys Val Phe Phe Glu Met Glu Glu Leu Lys Glu 
705                 710                 715                 720 


Asp Asp Tyr Tyr Gly Ile Thr Leu Ala Lys Glu Ser Asp His Gln Phe 
                725                 730                 735     


Leu Leu Ala Asn Gln Leu Val Val His Asn Ser Thr Tyr Ala Ser Leu 
            740                 745                 750         


Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu 
        755                 760                 765             


Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His 
    770                 775                 780                 


Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser 
785                 790                 795                 800 


Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
                805                 810 


<210>  453
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Zro_VMA

<400>  453

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Ala Lys Gly Thr Glu Val Met Met Ser Asp Gly Ser 
    290                 295                 300                 


Ile Lys Glu Val Glu Gly Ile Glu Val Gly Gln Glu Val Met Gly Lys 
305                 310                 315                 320 


Asp Gly Lys Pro Arg Glu Val Val Gly Thr Pro Ser Gly Arg Glu Lys 
                325                 330                 335     


Met Tyr Lys Val Ser His Lys Thr Ala His Arg Ala His Lys Ser Asp 
            340                 345                 350         


Ser Thr Ser Glu Arg Phe Gly Leu Phe Glu Tyr Thr Cys Asn Ala Thr 
        355                 360                 365             


His Lys Leu Val Val Arg Thr Ser Arg Ser Cys Arg Pro Leu Val Arg 
    370                 375                 380                 


Asn Ile Gln Gly Thr Asp Tyr Val Glu Val Cys Leu Phe Asn Met Thr 
385                 390                 395                 400 


Lys Lys Thr Leu Glu Asp Gly Arg Val Ile Asp Ile Val Glu Glu Thr 
                405                 410                 415     


Ser Asp Phe Tyr Pro Ala Val Glu Gly Pro Glu Lys Ala Leu Arg Ile 
            420                 425                 430         


Leu Lys Glu Tyr Ala Glu Ala Asp Gly Gly Lys Glu Tyr Phe Glu Trp 
        435                 440                 445             


Thr Ile Glu Ala Arg Asp Val Ala Leu Leu Ser Ala Gln Val Arg Lys 
    450                 455                 460                 


Ala Thr Tyr Gln Leu Ser Ala Pro Val Leu Leu Glu Asn Asn His Phe 
465                 470                 475                 480 


Ser His Tyr Leu Lys Asp Ser Asn Ser Ala Val Gly Asn Asp Thr Val 
                485                 490                 495     


Arg Ala Leu Ser Tyr Phe Leu Gly Leu Trp Ile Gly Asp Gly Met Leu 
            500                 505                 510         


Asn Asn Ala Ala Thr Phe Ser Val Asp Ser Gln Asn Ala Ser Leu Leu 
        515                 520                 525             


Asn Arg Ile Asn Glu Phe Ala Glu Val Leu Gly Leu Ser Ala Glu Tyr 
    530                 535                 540                 


Lys Asp Ser Gln Glu Pro Lys Arg Ala Lys Thr Val Asn Leu Tyr Ala 
545                 550                 555                 560 


Lys Ala Ile Arg Asp Glu Gly Val Arg Lys Asn Leu Asp Thr His Asn 
                565                 570                 575     


Leu Leu Trp Asp Ala Ile Val Asp Leu Gly Tyr Leu Lys Asp Asp Ser 
            580                 585                 590         


Lys Asn Val Pro Gly Tyr Ile Cys Ser Asp Ser Phe Gln His Arg Glu 
        595                 600                 605             


Val Phe Leu Ala Gly Ile Ile Asp Ser Thr Gly Tyr Val Ser Asp Glu 
    610                 615                 620                 


Thr Ala Thr Val Lys Thr Ile Asp Gln Ser Val Met Thr Gly Thr Val 
625                 630                 635                 640 


Ala Val Ala Arg Ser Leu Gly Ile Asn Val Ser Val Asp Val Glu Val 
                645                 650                 655     


Asp Glu Asp Gly Val Asp Arg Ser Phe Val Tyr Ala Ile Tyr Met Asp 
            660                 665                 670         


Arg Ser Asp Ala Leu Leu Ala Val Leu Ala Asn Cys Ala Ser Asn Asn 
        675                 680                 685             


Lys Gln Ile Glu Ala Pro Pro His Gly Val Ile Arg Glu Phe Asn Lys 
    690                 695                 700                 


Ala Tyr Phe Glu Met Glu Glu Leu Glu Glu Asp Glu Tyr Tyr Gly Leu 
705                 710                 715                 720 


Thr Leu Ser Asn Glu Ser Asp His Gln Phe Leu Leu Ala Asn Gln Leu 
                725                 730                 735     


Val Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
            740                 745                 750         


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
        755                 760                 765             


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
    770                 775                 780                 


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
785                 790                 795                 800 


Ala Ala Thr Arg 
                


<210>  454
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct NI-GG-6H

<400>  454

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Asp Leu Lys Thr Gln Val Gln Thr Pro Gln Gly Met 
    290                 295                 300                 


Lys Glu Ile Ser Asn Ile Gln Val Gly Asp Leu Val Leu Ser Asn Thr 
305                 310                 315                 320 


Gly Tyr Asn Glu Val Leu Asn Val Phe Pro Lys Ser Lys Lys Lys Ser 
                325                 330                 335     


Tyr Lys Ile Thr Leu Glu Asp Gly Lys Glu Ile Ile Cys Ser Glu Glu 
            340                 345                 350         


His Leu Phe Pro Thr Gln Thr Gly Glu Met Asn Ile Ser Gly Gly Leu 
        355                 360                 365             


Lys Glu Gly Met Cys Leu Tyr Val Lys Glu Gly Gly His His His His 
    370                 375                 380                 


His His 
385     


<210>  455
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct IC-SUMO-6H

<400>  455

Met Met Leu Lys Lys Ile Leu Lys Ile Glu Glu Leu Asp Glu Arg Glu 
1               5                   10                  15      


Leu Ile Asp Ile Glu Val Ser Gly Asn His Leu Phe Tyr Ala Asn Asp 
            20                  25                  30          


Ile Leu Thr His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
        35                  40                  45              


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
    50                  55                  60                  


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
65                  70                  75                  80  


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
                85                  90                  95      


Glu Ala Ala Thr Arg Met Gly Ser Leu Gln Asp Ser Glu Val Asn Gln 
            100                 105                 110         


Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His Ile 
        115                 120                 125             


Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys 
    130                 135                 140                 


Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg Gln 
145                 150                 155                 160 


Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr Asp Gly Ile Glu Ile 
                165                 170                 175     


Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile 
            180                 185                 190         


Ile Glu Ala His Arg Glu Gln Ile Gly Gly His His His His His His 
        195                 200                 205             


<210>  456
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_IMPDH-NI

<400>  456

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Phe Val Pro 
            100                 105                 110         


Gly Thr Leu Val Asn Thr Glu Asn Gly Leu Lys Lys Ile Glu Glu Ile 
        115                 120                 125             


Lys Val Gly Asp Lys Val Phe Ser His Thr Gly Lys Leu Gln Glu Val 
    130                 135                 140                 


Val Asp Thr Leu Ile Phe Asp Arg Asp Glu Glu Ile Ile Ser Ile Asn 
145                 150                 155                 160 


Gly Ile Asp Cys Thr Lys Asn His Glu Phe Tyr Val Ile Asp Lys Glu 
                165                 170                 175     


Asn Ala Asn Arg Val Asn Glu Asp Asn Ile His Leu Phe Ala Arg Trp 
            180                 185                 190         


Val His Ala Glu Glu Leu Asp Met Lys Lys His Leu Leu Ile Glu Leu 
        195                 200                 205             


Glu 
    


<210>  457
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_IMPDH-NI

<400>  457

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Cys Phe Val Pro Gly Thr Leu Val Asn Thr Glu Asn Gly Leu 
                245                 250                 255     


Lys Lys Ile Glu Glu Ile Lys Val Gly Asp Lys Val Phe Ser His Thr 
            260                 265                 270         


Gly Lys Leu Gln Glu Val Val Asp Thr Leu Ile Phe Asp Arg Asp Glu 
        275                 280                 285             


Glu Ile Ile Ser Ile Asn Gly Ile Asp Cys Thr Lys Asn His Glu Phe 
    290                 295                 300                 


Tyr Val Ile Asp Lys Glu Asn Ala Asn Arg Val Asn Glu Asp Asn Ile 
305                 310                 315                 320 


His Leu Phe Ala Arg Trp Val His Ala Glu Glu Leu Asp Met Lys Lys 
                325                 330                 335     


His Leu Leu Ile Glu Leu Glu 
            340             


<210>  458
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_IMPDH-NI

<400>  458

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Cys Phe Val Pro Gly Thr 
            260                 265                 270         


Leu Val Asn Thr Glu Asn Gly Leu Lys Lys Ile Glu Glu Ile Lys Val 
        275                 280                 285             


Gly Asp Lys Val Phe Ser His Thr Gly Lys Leu Gln Glu Val Val Asp 
    290                 295                 300                 


Thr Leu Ile Phe Asp Arg Asp Glu Glu Ile Ile Ser Ile Asn Gly Ile 
305                 310                 315                 320 


Asp Cys Thr Lys Asn His Glu Phe Tyr Val Ile Asp Lys Glu Asn Ala 
                325                 330                 335     


Asn Arg Val Asn Glu Asp Asn Ile His Leu Phe Ala Arg Trp Val His 
            340                 345                 350         


Ala Glu Glu Leu Asp Met Lys Lys His Leu Leu Ile Glu Leu Glu 
        355                 360                 365         


<210>  459
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_IMPDH-NI

<400>  459

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Phe Val Pro Gly Thr Leu Val Asn Thr Glu Asn Gly Leu 
    290                 295                 300                 


Lys Lys Ile Glu Glu Ile Lys Val Gly Asp Lys Val Phe Ser His Thr 
305                 310                 315                 320 


Gly Lys Leu Gln Glu Val Val Asp Thr Leu Ile Phe Asp Arg Asp Glu 
                325                 330                 335     


Glu Ile Ile Ser Ile Asn Gly Ile Asp Cys Thr Lys Asn His Glu Phe 
            340                 345                 350         


Tyr Val Ile Asp Lys Glu Asn Ala Asn Arg Val Asn Glu Asp Asn Ile 
        355                 360                 365             


His Leu Phe Ala Arg Trp Val His Ala Glu Glu Leu Asp Met Lys Lys 
    370                 375                 380                 


His Leu Leu Ile Glu Leu Glu 
385                 390     


<210>  460
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_IMPDH-NI

<400>  460

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Cys Phe Val Pro Gly Thr Leu Val Asn Thr Glu Asn Gly 
    290                 295                 300                 


Leu Lys Lys Ile Glu Glu Ile Lys Val Gly Asp Lys Val Phe Ser His 
305                 310                 315                 320 


Thr Gly Lys Leu Gln Glu Val Val Asp Thr Leu Ile Phe Asp Arg Asp 
                325                 330                 335     


Glu Glu Ile Ile Ser Ile Asn Gly Ile Asp Cys Thr Lys Asn His Glu 
            340                 345                 350         


Phe Tyr Val Ile Asp Lys Glu Asn Ala Asn Arg Val Asn Glu Asp Asn 
        355                 360                 365             


Ile His Leu Phe Ala Arg Trp Val His Ala Glu Glu Leu Asp Met Lys 
    370                 375                 380                 


Lys His Leu Leu Ile Glu Leu Glu 
385                 390         


<210>  461
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_gp41-1-NI

<400>  461

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Asp Leu 
            100                 105                 110         


Lys Thr Gln Val Gln Thr Pro Gln Gly Met Lys Glu Ile Ser Asn Ile 
        115                 120                 125             


Gln Val Gly Asp Leu Val Leu Ser Asn Thr Gly Tyr Asn Glu Val Leu 
    130                 135                 140                 


Asn Val Phe Pro Lys Ser Lys Lys Lys Ser Tyr Lys Ile Thr Leu Glu 
145                 150                 155                 160 


Asp Gly Lys Glu Ile Ile Cys Ser Glu Glu His Leu Phe Pro Thr Gln 
                165                 170                 175     


Thr Gly Glu Met Asn Ile Ser Gly Gly Leu Lys Glu Gly Met Cys Leu 
            180                 185                 190         


Tyr Val Lys Glu 
        195     


<210>  462
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_gp41-1-NI

<400>  462

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Cys Leu Asp Leu Lys Thr Gln Val Gln Thr Pro Gln Gly Met 
                245                 250                 255     


Lys Glu Ile Ser Asn Ile Gln Val Gly Asp Leu Val Leu Ser Asn Thr 
            260                 265                 270         


Gly Tyr Asn Glu Val Leu Asn Val Phe Pro Lys Ser Lys Lys Lys Ser 
        275                 280                 285             


Tyr Lys Ile Thr Leu Glu Asp Gly Lys Glu Ile Ile Cys Ser Glu Glu 
    290                 295                 300                 


His Leu Phe Pro Thr Gln Thr Gly Glu Met Asn Ile Ser Gly Gly Leu 
305                 310                 315                 320 


Lys Glu Gly Met Cys Leu Tyr Val Lys Glu 
                325                 330 


<210>  463
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_gp41-1-NI

<400>  463

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Cys Leu Asp Leu Lys Thr 
            260                 265                 270         


Gln Val Gln Thr Pro Gln Gly Met Lys Glu Ile Ser Asn Ile Gln Val 
        275                 280                 285             


Gly Asp Leu Val Leu Ser Asn Thr Gly Tyr Asn Glu Val Leu Asn Val 
    290                 295                 300                 


Phe Pro Lys Ser Lys Lys Lys Ser Tyr Lys Ile Thr Leu Glu Asp Gly 
305                 310                 315                 320 


Lys Glu Ile Ile Cys Ser Glu Glu His Leu Phe Pro Thr Gln Thr Gly 
                325                 330                 335     


Glu Met Asn Ile Ser Gly Gly Leu Lys Glu Gly Met Cys Leu Tyr Val 
            340                 345                 350         


Lys Glu 
        


<210>  464
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_gp41-1-NI

<400>  464

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Asp Leu Lys Thr Gln Val Gln Thr Pro Gln Gly Met 
    290                 295                 300                 


Lys Glu Ile Ser Asn Ile Gln Val Gly Asp Leu Val Leu Ser Asn Thr 
305                 310                 315                 320 


Gly Tyr Asn Glu Val Leu Asn Val Phe Pro Lys Ser Lys Lys Lys Ser 
                325                 330                 335     


Tyr Lys Ile Thr Leu Glu Asp Gly Lys Glu Ile Ile Cys Ser Glu Glu 
            340                 345                 350         


His Leu Phe Pro Thr Gln Thr Gly Glu Met Asn Ile Ser Gly Gly Leu 
        355                 360                 365             


Lys Glu Gly Met Cys Leu Tyr Val Lys Glu 
    370                 375             


<210>  465
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_gp41-1-NI

<400>  465

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Cys Leu Asp Leu Lys Thr Gln Val Gln Thr Pro Gln Gly 
    290                 295                 300                 


Met Lys Glu Ile Ser Asn Ile Gln Val Gly Asp Leu Val Leu Ser Asn 
305                 310                 315                 320 


Thr Gly Tyr Asn Glu Val Leu Asn Val Phe Pro Lys Ser Lys Lys Lys 
                325                 330                 335     


Ser Tyr Lys Ile Thr Leu Glu Asp Gly Lys Glu Ile Ile Cys Ser Glu 
            340                 345                 350         


Glu His Leu Phe Pro Thr Gln Thr Gly Glu Met Asn Ile Ser Gly Gly 
        355                 360                 365             


Leu Lys Glu Gly Met Cys Leu Tyr Val Lys Glu 
    370                 375                 


<210>  466
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_gp41-8-NI

<400>  466

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ser Leu 
            100                 105                 110         


Asp Thr Met Val Val Thr Asn Gly Lys Ala Ile Glu Ile Arg Asp Val 
        115                 120                 125             


Lys Val Gly Asp Trp Leu Glu Ser Glu Leu Gly Pro Val Gln Val Thr 
    130                 135                 140                 


Glu Val Leu Pro Ile Ile Lys Gln Pro Val Phe Glu Ile Val Leu Lys 
145                 150                 155                 160 


Ser Lys Ser Gly Lys Lys Ile Arg Val Ser Ala Asn His Lys Phe Pro 
                165                 170                 175     


Thr Lys Asp Gly Leu Lys Thr Ile Asn Ser Gly Leu Lys Val Gly Asp 
            180                 185                 190         


Phe Leu Arg Ser Arg Ala Lys 
        195                 


<210>  467
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_gp41-8-NI

<400>  467

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Cys Leu Ser Leu Asp Thr Met Val Val Thr Asn Gly Lys Ala 
                245                 250                 255     


Ile Glu Ile Arg Asp Val Lys Val Gly Asp Trp Leu Glu Ser Glu Leu 
            260                 265                 270         


Gly Pro Val Gln Val Thr Glu Val Leu Pro Ile Ile Lys Gln Pro Val 
        275                 280                 285             


Phe Glu Ile Val Leu Lys Ser Lys Ser Gly Lys Lys Ile Arg Val Ser 
    290                 295                 300                 


Ala Asn His Lys Phe Pro Thr Lys Asp Gly Leu Lys Thr Ile Asn Ser 
305                 310                 315                 320 


Gly Leu Lys Val Gly Asp Phe Leu Arg Ser Arg Ala Lys 
                325                 330             


<210>  468
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_gp41-8-NI

<400>  468

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Cys Leu Ser Leu Asp Thr 
            260                 265                 270         


Met Val Val Thr Asn Gly Lys Ala Ile Glu Ile Arg Asp Val Lys Val 
        275                 280                 285             


Gly Asp Trp Leu Glu Ser Glu Leu Gly Pro Val Gln Val Thr Glu Val 
    290                 295                 300                 


Leu Pro Ile Ile Lys Gln Pro Val Phe Glu Ile Val Leu Lys Ser Lys 
305                 310                 315                 320 


Ser Gly Lys Lys Ile Arg Val Ser Ala Asn His Lys Phe Pro Thr Lys 
                325                 330                 335     


Asp Gly Leu Lys Thr Ile Asn Ser Gly Leu Lys Val Gly Asp Phe Leu 
            340                 345                 350         


Arg Ser Arg Ala Lys 
        355         


<210>  469
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_gp41-8-NI

<400>  469

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ser Leu Asp Thr Met Val Val Thr Asn Gly Lys Ala 
    290                 295                 300                 


Ile Glu Ile Arg Asp Val Lys Val Gly Asp Trp Leu Glu Ser Glu Leu 
305                 310                 315                 320 


Gly Pro Val Gln Val Thr Glu Val Leu Pro Ile Ile Lys Gln Pro Val 
                325                 330                 335     


Phe Glu Ile Val Leu Lys Ser Lys Ser Gly Lys Lys Ile Arg Val Ser 
            340                 345                 350         


Ala Asn His Lys Phe Pro Thr Lys Asp Gly Leu Lys Thr Ile Asn Ser 
        355                 360                 365             


Gly Leu Lys Val Gly Asp Phe Leu Arg Ser Arg Ala Lys 
    370                 375                 380     


<210>  470
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_gp41-8-NI

<400>  470

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Cys Leu Ser Leu Asp Thr Met Val Val Thr Asn Gly Lys 
    290                 295                 300                 


Ala Ile Glu Ile Arg Asp Val Lys Val Gly Asp Trp Leu Glu Ser Glu 
305                 310                 315                 320 


Leu Gly Pro Val Gln Val Thr Glu Val Leu Pro Ile Ile Lys Gln Pro 
                325                 330                 335     


Val Phe Glu Ile Val Leu Lys Ser Lys Ser Gly Lys Lys Ile Arg Val 
            340                 345                 350         


Ser Ala Asn His Lys Phe Pro Thr Lys Asp Gly Leu Lys Thr Ile Asn 
        355                 360                 365             


Ser Gly Leu Lys Val Gly Asp Phe Leu Arg Ser Arg Ala Lys 
    370                 375                 380         


<210>  471
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_NrdJ-1-NI

<400>  471

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Val Gly 
            100                 105                 110         


Ser Ser Glu Ile Ile Thr Arg Asn Tyr Gly Lys Thr Thr Ile Lys Glu 
        115                 120                 125             


Val Val Glu Ile Phe Asp Asn Asp Lys Asn Ile Gln Val Leu Ala Phe 
    130                 135                 140                 


Asn Thr His Thr Asp Asn Ile Glu Trp Ala Pro Ile Lys Ala Ala Gln 
145                 150                 155                 160 


Leu Thr Arg Pro Asn Ala Glu Leu Val Glu Leu Glu Ile Asp Thr Leu 
                165                 170                 175     


His Gly Val Lys Thr Ile Arg Cys Thr Pro Asp His Pro Val Tyr Thr 
            180                 185                 190         


Lys Asn Arg Gly Tyr Val Arg Ala Asp Glu Leu Thr Asp Asp Asp Glu 
        195                 200                 205             


Leu Val Val Ala Ile 
    210             


<210>  472
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_NrdJ-1-NI

<400>  472

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Cys Leu Val Gly Ser Ser Glu Ile Ile Thr Arg Asn Tyr Gly 
                245                 250                 255     


Lys Thr Thr Ile Lys Glu Val Val Glu Ile Phe Asp Asn Asp Lys Asn 
            260                 265                 270         


Ile Gln Val Leu Ala Phe Asn Thr His Thr Asp Asn Ile Glu Trp Ala 
        275                 280                 285             


Pro Ile Lys Ala Ala Gln Leu Thr Arg Pro Asn Ala Glu Leu Val Glu 
    290                 295                 300                 


Leu Glu Ile Asp Thr Leu His Gly Val Lys Thr Ile Arg Cys Thr Pro 
305                 310                 315                 320 


Asp His Pro Val Tyr Thr Lys Asn Arg Gly Tyr Val Arg Ala Asp Glu 
                325                 330                 335     


Leu Thr Asp Asp Asp Glu Leu Val Val Ala Ile 
            340                 345         


<210>  473
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_NrdJ-1-NI

<400>  473

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Cys Leu Val Gly Ser Ser 
            260                 265                 270         


Glu Ile Ile Thr Arg Asn Tyr Gly Lys Thr Thr Ile Lys Glu Val Val 
        275                 280                 285             


Glu Ile Phe Asp Asn Asp Lys Asn Ile Gln Val Leu Ala Phe Asn Thr 
    290                 295                 300                 


His Thr Asp Asn Ile Glu Trp Ala Pro Ile Lys Ala Ala Gln Leu Thr 
305                 310                 315                 320 


Arg Pro Asn Ala Glu Leu Val Glu Leu Glu Ile Asp Thr Leu His Gly 
                325                 330                 335     


Val Lys Thr Ile Arg Cys Thr Pro Asp His Pro Val Tyr Thr Lys Asn 
            340                 345                 350         


Arg Gly Tyr Val Arg Ala Asp Glu Leu Thr Asp Asp Asp Glu Leu Val 
        355                 360                 365             


Val Ala Ile 
    370     


<210>  474
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_NrdJ-1-NI

<400>  474

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Val Gly Ser Ser Glu Ile Ile Thr Arg Asn Tyr Gly 
    290                 295                 300                 


Lys Thr Thr Ile Lys Glu Val Val Glu Ile Phe Asp Asn Asp Lys Asn 
305                 310                 315                 320 


Ile Gln Val Leu Ala Phe Asn Thr His Thr Asp Asn Ile Glu Trp Ala 
                325                 330                 335     


Pro Ile Lys Ala Ala Gln Leu Thr Arg Pro Asn Ala Glu Leu Val Glu 
            340                 345                 350         


Leu Glu Ile Asp Thr Leu His Gly Val Lys Thr Ile Arg Cys Thr Pro 
        355                 360                 365             


Asp His Pro Val Tyr Thr Lys Asn Arg Gly Tyr Val Arg Ala Asp Glu 
    370                 375                 380                 


Leu Thr Asp Asp Asp Glu Leu Val Val Ala Ile 
385                 390                 395 


<210>  475
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_NrdJ-1-NI

<400>  475

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Cys Leu Val Gly Ser Ser Glu Ile Ile Thr Arg Asn Tyr 
    290                 295                 300                 


Gly Lys Thr Thr Ile Lys Glu Val Val Glu Ile Phe Asp Asn Asp Lys 
305                 310                 315                 320 


Asn Ile Gln Val Leu Ala Phe Asn Thr His Thr Asp Asn Ile Glu Trp 
                325                 330                 335     


Ala Pro Ile Lys Ala Ala Gln Leu Thr Arg Pro Asn Ala Glu Leu Val 
            340                 345                 350         


Glu Leu Glu Ile Asp Thr Leu His Gly Val Lys Thr Ile Arg Cys Thr 
        355                 360                 365             


Pro Asp His Pro Val Tyr Thr Lys Asn Arg Gly Tyr Val Arg Ala Asp 
    370                 375                 380                 


Glu Leu Thr Asp Asp Asp Glu Leu Val Val Ala Ile 
385                 390                 395     


<210>  476
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_IMPDH-IC

<400>  476

Met Lys Phe Lys Leu Lys Glu Ile Thr Ser Ile Glu Thr Lys His Tyr 
1               5                   10                  15      


Lys Gly Lys Val His Asp Leu Thr Val Asn Gln Asp His Ser Tyr Asn 
            20                  25                  30          


Val Arg Gly Thr Val Val His Asn Ser Gly Val Lys Val Ala Val Leu 
        35                  40                  45              


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
    50                  55                  60                  


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
65                  70                  75                  80  


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
                85                  90                  95      


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
            100                 105                 110         


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
        115                 120                 125             


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
    130                 135                 140                 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
145                 150                 155                 160 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
                165                 170                 175     


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
            180                 185                 190         


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
        195                 200                 205             


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
    210                 215                 220                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
225                 230                 235                 240 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                245                 250                 255     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            260                 265                 270         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        275                 280                 285     


<210>  477
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_IMPDH-IC

<400>  477

Met Lys Phe Lys Leu Lys Glu Ile Thr Ser Ile Glu Thr Lys His Tyr 
1               5                   10                  15      


Lys Gly Lys Val His Asp Leu Thr Val Asn Gln Asp His Ser Tyr Asn 
            20                  25                  30          


Val Arg Gly Thr Val Val His Asn Ser Ile Ser Tyr Pro Ala Arg Tyr 
        35                  40                  45              


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
    50                  55                  60                  


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
65                  70                  75                  80  


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
                85                  90                  95      


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            100                 105                 110         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        115                 120                 125             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    130                 135                 140                 


Val Asn Ala Glu Ala Ala Thr Arg 
145                 150         


<210>  478
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_IMPDH-IC

<400>  478

Met Lys Phe Lys Leu Lys Glu Ile Thr Ser Ile Glu Thr Lys His Tyr 
1               5                   10                  15      


Lys Gly Lys Val His Asp Leu Thr Val Asn Gln Asp His Ser Tyr Asn 
            20                  25                  30          


Val Arg Gly Thr Val Val His Asn Ser Phe Ser Gln Tyr Gly Ala Gly 
        35                  40                  45              


Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly 
    50                  55                  60                  


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
65                  70                  75                  80  


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
                85                  90                  95      


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
            100                 105                 110         


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        115                 120                 125             


<210>  479
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_IMPDH-IC

<400>  479

Met Lys Phe Lys Leu Lys Glu Ile Thr Ser Ile Glu Thr Lys His Tyr 
1               5                   10                  15      


Lys Gly Lys Val His Asp Leu Thr Val Asn Gln Asp His Ser Tyr Asn 
            20                  25                  30          


Val Arg Gly Thr Val Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
        35                  40                  45              


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
    50                  55                  60                  


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
65                  70                  75                  80  


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
                85                  90                  95      


Val Asn Ala Glu Ala Ala Thr Arg 
            100                 


<210>  480
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_IMPDH-IC

<400>  480

Met Lys Phe Lys Leu Lys Glu Ile Thr Ser Ile Glu Thr Lys His Tyr 
1               5                   10                  15      


Lys Gly Lys Val His Asp Leu Thr Val Asn Gln Asp His Ser Tyr Asn 
            20                  25                  30          


Val Arg Gly Thr Val Val His Asn Thr Tyr Ala Ser Leu Asn Gly Thr 
        35                  40                  45              


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
    50                  55                  60                  


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
65                  70                  75                  80  


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
                85                  90                  95      


Asn Ala Glu Ala Ala Thr Arg 
            100             


<210>  481
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_gp41-1-IC

<400>  481

Met Met Leu Lys Lys Ile Leu Lys Ile Glu Glu Leu Asp Glu Arg Glu 
1               5                   10                  15      


Leu Ile Asp Ile Glu Val Ser Gly Asn His Leu Phe Tyr Ala Asn Asp 
            20                  25                  30          


Ile Leu Thr His Asn Ser Gly Val Lys Val Ala Val Leu Asp Thr Gly 
        35                  40                  45              


Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe Val 
    50                  55                  60                  


Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His Val 
65                  70                  75                  80  


Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly Val 
                85                  90                  95      


Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser Gly 
            100                 105                 110         


Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly Asn 
        115                 120                 125             


Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro Ser 
    130                 135                 140                 


Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val Leu 
145                 150                 155                 160 


Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr Pro 
                165                 170                 175     


Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn 
            180                 185                 190         


Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala 
        195                 200                 205             


Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser 
    210                 215                 220                 


Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala 
225                 230                 235                 240 


Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn 
                245                 250                 255     


His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly 
            260                 265                 270         


Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        275                 280             


<210>  482
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_gp41-1-IC

<400>  482

Met Met Leu Lys Lys Ile Leu Lys Ile Glu Glu Leu Asp Glu Arg Glu 
1               5                   10                  15      


Leu Ile Asp Ile Glu Val Ser Gly Asn His Leu Phe Tyr Ala Asn Asp 
            20                  25                  30          


Ile Leu Thr His Asn Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala 
        35                  40                  45              


Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser 
    50                  55                  60                  


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
65                  70                  75                  80  


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
                85                  90                  95      


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
            100                 105                 110         


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
        115                 120                 125             


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
    130                 135                 140                 


Glu Ala Ala Thr Arg 
145                 


<210>  483
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_gp41-1-IC

<400>  483

Met Met Leu Lys Lys Ile Leu Lys Ile Glu Glu Leu Asp Glu Arg Glu 
1               5                   10                  15      


Leu Ile Asp Ile Glu Val Ser Gly Asn His Leu Phe Tyr Ala Asn Asp 
            20                  25                  30          


Ile Leu Thr His Asn Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile 
        35                  40                  45              


Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr 
    50                  55                  60                  


Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
65                  70                  75                  80  


Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile 
                85                  90                  95      


Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu 
            100                 105                 110         


Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        115                 120                 125 


<210>  484
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_gp41-1-IC

<400>  484

Met Met Leu Lys Lys Ile Leu Lys Ile Glu Glu Leu Asp Glu Arg Glu 
1               5                   10                  15      


Leu Ile Asp Ile Glu Val Ser Gly Asn His Leu Phe Tyr Ala Asn Asp 
            20                  25                  30          


Ile Leu Thr His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
        35                  40                  45              


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
    50                  55                  60                  


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
65                  70                  75                  80  


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
                85                  90                  95      


Glu Ala Ala Thr Arg 
            100     


<210>  485
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_gp41-1-IC

<400>  485

Met Met Leu Lys Lys Ile Leu Lys Ile Glu Glu Leu Asp Glu Arg Glu 
1               5                   10                  15      


Leu Ile Asp Ile Glu Val Ser Gly Asn His Leu Phe Tyr Ala Asn Asp 
            20                  25                  30          


Ile Leu Thr His Asn Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala 
        35                  40                  45              


Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro 
    50                  55                  60                  


Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr 
65                  70                  75                  80  


Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu 
                85                  90                  95      


Ala Ala Thr Arg 
            100 


<210>  486
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_gp41-8-IC

<400>  486

Met Cys Glu Ile Phe Glu Asn Glu Ile Asp Trp Asp Glu Ile Ala Ser 
1               5                   10                  15      


Ile Glu Tyr Val Gly Val Glu Glu Thr Ile Asp Ile Asn Val Thr Asn 
            20                  25                  30          


Asp Arg Leu Phe Phe Ala Asn Gly Ile Leu Thr His Asn Ser Gly Val 
        35                  40                  45              


Lys Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn 
    50                  55                  60                  


Ile Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp 
65                  70                  75                  80  


Gly Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn 
                85                  90                  95      


Asn Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala 
            100                 105                 110         


Val Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala 
        115                 120                 125             


Gln Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu 
    130                 135                 140                 


Ser Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn 
145                 150                 155                 160 


Ser Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser 
                165                 170                 175     


Gly Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala 
            180                 185                 190         


Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr 
        195                 200                 205             


Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr 
    210                 215                 220                 


Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
225                 230                 235                 240 


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser 
                245                 250                 255     


Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser 
            260                 265                 270         


Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala 
        275                 280                 285             


Ala Thr Arg 
    290     


<210>  487
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_gp41-8-IC

<400>  487

Met Cys Glu Ile Phe Glu Asn Glu Ile Asp Trp Asp Glu Ile Ala Ser 
1               5                   10                  15      


Ile Glu Tyr Val Gly Val Glu Glu Thr Ile Asp Ile Asn Val Thr Asn 
            20                  25                  30          


Asp Arg Leu Phe Phe Ala Asn Gly Ile Leu Thr His Asn Ser Ile Ser 
        35                  40                  45              


Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln 
    50                  55                  60                  


Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile 
65                  70                  75                  80  


Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr 
                85                  90                  95      


Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
            100                 105                 110         


Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile 
        115                 120                 125             


Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu 
    130                 135                 140                 


Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
145                 150                 155         


<210>  488
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_gp41-8-IC

<400>  488

Met Cys Glu Ile Phe Glu Asn Glu Ile Asp Trp Asp Glu Ile Ala Ser 
1               5                   10                  15      


Ile Glu Tyr Val Gly Val Glu Glu Thr Ile Asp Ile Asn Val Thr Asn 
            20                  25                  30          


Asp Arg Leu Phe Phe Ala Asn Gly Ile Leu Thr His Asn Ser Phe Ser 
        35                  40                  45              


Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln 
    50                  55                  60                  


Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met 
65                  70                  75                  80  


Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn 
                85                  90                  95      


Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala 
            100                 105                 110         


Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala 
        115                 120                 125             


Glu Ala Ala Thr Arg 
    130             


<210>  489
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_gp41-8-IC

<400>  489

Met Cys Glu Ile Phe Glu Asn Glu Ile Asp Trp Asp Glu Ile Ala Ser 
1               5                   10                  15      


Ile Glu Tyr Val Gly Val Glu Glu Thr Ile Asp Ile Asn Val Thr Asn 
            20                  25                  30          


Asp Arg Leu Phe Phe Ala Asn Gly Ile Leu Thr His Asn Ser Thr Tyr 
        35                  40                  45              


Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
    50                  55                  60                  


Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile 
65                  70                  75                  80  


Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu 
                85                  90                  95      


Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            100                 105                 


<210>  490
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_gp41-8-IC

<400>  490

Met Cys Glu Ile Phe Glu Asn Glu Ile Asp Trp Asp Glu Ile Ala Ser 
1               5                   10                  15      


Ile Glu Tyr Val Gly Val Glu Glu Thr Ile Asp Ile Asn Val Thr Asn 
            20                  25                  30          


Asp Arg Leu Phe Phe Ala Asn Gly Ile Leu Thr His Asn Thr Tyr Ala 
        35                  40                  45              


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
    50                  55                  60                  


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
65                  70                  75                  80  


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
                85                  90                  95      


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            100                 105             


<210>  491
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_NrdJ-1-IC

<400>  491

Met Glu Ala Lys Thr Tyr Ile Gly Lys Leu Lys Ser Arg Lys Ile Val 
1               5                   10                  15      


Ser Asn Glu Asp Thr Tyr Asp Ile Gln Thr Ser Thr His Asn Phe Phe 
            20                  25                  30          


Ala Asn Asp Ile Leu Val His Asn Ser Gly Val Lys Val Ala Val Leu 
        35                  40                  45              


Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala 
    50                  55                  60                  


Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly 
65                  70                  75                  80  


Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val 
                85                  90                  95      


Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly 
            100                 105                 110         


Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
        115                 120                 125             


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
    130                 135                 140                 


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
145                 150                 155                 160 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
                165                 170                 175     


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
            180                 185                 190         


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
        195                 200                 205             


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
    210                 215                 220                 


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
225                 230                 235                 240 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
                245                 250                 255     


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
            260                 265                 270         


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        275                 280                 285     


<210>  492
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_NrdJ-1-IC

<400>  492

Met Glu Ala Lys Thr Tyr Ile Gly Lys Leu Lys Ser Arg Lys Ile Val 
1               5                   10                  15      


Ser Asn Glu Asp Thr Tyr Asp Ile Gln Thr Ser Thr His Asn Phe Phe 
            20                  25                  30          


Ala Asn Asp Ile Leu Val His Asn Ser Ile Ser Tyr Pro Ala Arg Tyr 
        35                  40                  45              


Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala 
    50                  55                  60                  


Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val Ala Pro Gly Val 
65                  70                  75                  80  


Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly 
                85                  90                  95      


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
            100                 105                 110         


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
        115                 120                 125             


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
    130                 135                 140                 


Val Asn Ala Glu Ala Ala Thr Arg 
145                 150         


<210>  493
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_NrdJ-1-IC

<400>  493

Met Glu Ala Lys Thr Tyr Ile Gly Lys Leu Lys Ser Arg Lys Ile Val 
1               5                   10                  15      


Ser Asn Glu Asp Thr Tyr Asp Ile Gln Thr Ser Thr His Asn Phe Phe 
            20                  25                  30          


Ala Asn Asp Ile Leu Val His Asn Ser Phe Ser Gln Tyr Gly Ala Gly 
        35                  40                  45              


Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly 
    50                  55                  60                  


Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val 
65                  70                  75                  80  


Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn 
                85                  90                  95      


Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser 
            100                 105                 110         


Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        115                 120                 125             


<210>  494
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_NrdJ-1-IC

<400>  494

Met Glu Ala Lys Thr Tyr Ile Gly Lys Leu Lys Ser Arg Lys Ile Val 
1               5                   10                  15      


Ser Asn Glu Asp Thr Tyr Asp Ile Gln Thr Ser Thr His Asn Phe Phe 
            20                  25                  30          


Ala Asn Asp Ile Leu Val His Asn Ser Thr Tyr Ala Ser Leu Asn Gly 
        35                  40                  45              


Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys 
    50                  55                  60                  


Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys 
65                  70                  75                  80  


Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu 
                85                  90                  95      


Val Asn Ala Glu Ala Ala Thr Arg 
            100                 


<210>  495
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_NrdJ-1-IC

<400>  495

Met Glu Ala Lys Thr Tyr Ile Gly Lys Leu Lys Ser Arg Lys Ile Val 
1               5                   10                  15      


Ser Asn Glu Asp Thr Tyr Asp Ile Gln Thr Ser Thr His Asn Phe Phe 
            20                  25                  30          


Ala Asn Asp Ile Leu Val His Asn Thr Tyr Ala Ser Leu Asn Gly Thr 
        35                  40                  45              


Ser Met Ala Thr Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Gln 
    50                  55                  60                  


Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn 
65                  70                  75                  80  


Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val 
                85                  90                  95      


Asn Ala Glu Ala Ala Thr Arg 
            100             


<210>  496
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Unc-ERS_RIR1_var7

<400>  496

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            260                 265                 270         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        275                 280                 285             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    290                 295                 300                 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Cys Val Thr Ala 
305                 310                 315                 320 


Asp Thr Trp Val Thr Thr Ala Glu Gly Pro Arg Gln Val Glu Glu Leu 
                325                 330                 335     


Ile Gly Lys Lys Phe Thr Ala Ile Val Asn Gly Glu Glu Trp Glu Ser 
            340                 345                 350         


Ser Glu Glu Gly Phe Phe Glu Thr Asp Val Lys Pro Val Tyr Thr Leu 
        355                 360                 365             


Lys Thr Ala Glu Gly Phe Glu Leu Arg Leu Thr Ala Asp His Pro Val 
    370                 375                 380                 


Met Lys Val Glu Arg Met Thr Arg Tyr Lys Val Glu Thr Gln Trp Ser 
385                 390                 395                 400 


Asn Ala Gly Asp Leu Lys Pro Gly Asp Lys Ile Ile Ile Asn Asn His 
                405                 410                 415     


Arg Asp Phe Gly Asn Trp Ser Val Lys Gly Lys Tyr Thr Glu Gly Glu 
            420                 425                 430         


Gly Tyr Leu Ile Gly Leu Leu Leu Gly Asp Gly Thr Ile Lys Lys Leu 
        435                 440                 445             


Asn Pro Trp Met Lys Ala Ile Ser Lys Lys Met Glu Lys Ala Ser Ala 
    450                 455                 460                 


Asp Phe Cys Glu Gly Ile Leu Arg Gly Leu Ser Asp Ala Asp Gly Ser 
465                 470                 475                 480 


Val Gln Gly Asn Gln Ser Lys Gly Val Ser Ile Arg Leu Ala Gln Ser 
                485                 490                 495     


Asp Val Glu Ile Leu Lys Ala Val Gln Arg Ile Leu Leu Arg Phe Gly 
            500                 505                 510         


Ile Phe Ser Lys Val Tyr Met Asn Arg Arg Gly Glu Arg Lys Val Lys 
        515                 520                 525             


Met Pro Asp Gly Lys Gly Gly Val Lys Glu Tyr Ile Thr Lys Pro Gln 
    530                 535                 540                 


His Glu Leu Val Ile Ser Asn Asp Asn Ile Leu Tyr Phe Ala Glu Arg 
545                 550                 555                 560 


Val Gly Phe Ser Asp Ala Glu Lys Met Glu Lys Leu Glu Lys Ala Ile 
                565                 570                 575     


Trp Asn Tyr Lys Arg Lys Met Asn Arg Glu Arg Phe Val Ala Ser Val 
            580                 585                 590         


Glu Glu Val Val Pro Asp Gly Val Glu Lys Val Tyr Asp Val Lys Ile 
        595                 600                 605             


Pro Gly Ile Asn Ala Phe Asn Ala Asn Gly Phe Val Val His Asn Ser 
    610                 615                 620                 


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
625                 630                 635                 640 


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
                645                 650                 655     


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
            660                 665                 670         


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
        675                 680                 685         


<210>  497
<211>  135
<212>  PRT
<213>  Clostridium thermocellum


<220>
<221>  MISC_FEATURE
<222>  (1)..(135)
<223>  Cth_ATPase_BIL

<400>  497

Cys Phe Val Ala Gly Thr Met Ile Leu Thr Val Ala Gly Leu Val Ala 
1               5                   10                  15      


Ile Glu Asn Ile Lys Ala Gly Asp Lys Val Ile Ala Thr Asn Pro Glu 
            20                  25                  30          


Thr Phe Glu Val Ala Glu Lys Thr Val Leu Glu Thr Tyr Val Arg Glu 
        35                  40                  45              


Thr Thr Glu Leu Leu His Leu Thr Ile Asn Gly Asp Val Ile Lys Thr 
    50                  55                  60                  


Thr Phe Glu His Leu Phe Tyr Ala Lys Asp Val Gly Phe Val Glu Ala 
65                  70                  75                  80  


Lys Glu Leu Gln Val Gly Asp Lys Leu Leu Asp Ser Lys Gly Asn Val 
                85                  90                  95      


Leu Val Val Glu Asp Lys Lys Ile Lys Ile Thr Asp Glu Pro Val Lys 
            100                 105                 110         


Val Tyr Asn Phe Gln Val Asp Asp Phe His Thr Tyr His Val Gly Cys 
        115                 120                 125             


Asn Gly Val Leu Val His Asn 
    130                 135 


<210>  498
<211>  347
<212>  PRT
<213>  Crocosphaera watsonii WH 8501


<220>
<221>  MISC_FEATURE
<222>  (1)..(347)
<223>  Cwa_RIR1

<400>  498

Cys Val Ala Pro Glu Thr Lys Ile Leu Thr Asp Arg Gly Gln Ile Ala 
1               5                   10                  15      


Ile Ala Asp Val Ala Gly Glu Lys Val Asn Ile Trp Asn Gly Ser Glu 
            20                  25                  30          


Trp Ser Glu Val Leu Val Lys Lys Thr Gly Glu Asn Gln Pro Leu Leu 
        35                  40                  45              


Lys Val His Phe Ser Asn Gly Glu Ser Leu Asp Cys Thr Tyr Tyr His 
    50                  55                  60                  


Lys Phe His Val Gln Glu Asn Tyr Lys Gly Lys Val Lys Ile Val Glu 
65                  70                  75                  80  


Ala Lys Asp Leu Gln Glu Gly Asp Lys Leu Ile Lys Tyr Arg Leu Pro 
                85                  90                  95      


Leu Val Glu Ser Glu Asn Asp Ile Asp Phe Pro Tyr Ala Tyr Thr Ser 
            100                 105                 110         


Gly Phe Phe Ser Gly Asp Gly Ser His Asp Gly Met Gly Lys Pro Glu 
        115                 120                 125             


Ile Asp Leu Tyr Gly Glu Lys Lys Glu Leu Leu Pro Phe Val Thr Val 
    130                 135                 140                 


Arg Asn Lys Tyr Tyr Gly Gly Ser Tyr Gly Asp Lys Ser Trp Arg Ile 
145                 150                 155                 160 


Glu Arg Asp Glu Val Ala Val Tyr Asp Asp Val Asn Gln Asp Arg Ile 
                165                 170                 175     


Val Cys Lys Leu Pro Leu Asp Ile Pro Ala Lys Phe Thr Val Pro Val 
            180                 185                 190         


Asn Gly Tyr Thr Ile Gln Ser Arg Leu Glu Trp Leu Ala Gly Leu Leu 
        195                 200                 205             


Asp Ala Asp Gly Thr Val Ala Arg Asn Gly Asp Asn Glu Ser Leu Gln 
    210                 215                 220                 


Val Ala Ser Thr His Gln Gln Phe Leu Leu Asp Ile Arg Leu Met Leu 
225                 230                 235                 240 


Gln Thr Leu Gly Val Asp Ser Lys Val Val Lys Met Asp Glu Met Gly 
                245                 250                 255     


Tyr Arg Ser Leu Pro Asp Gly Lys Gly Gly Tyr Gln Asp Tyr Phe Cys 
            260                 265                 270         


Gln Ala Lys Tyr Arg Leu Leu Ile Ser Ser Asn Gly Leu Phe Gln Leu 
        275                 280                 285             


Gly Glu Leu Gly Leu Lys Thr Asn Arg Leu Gln Trp Asn Leu Arg Glu 
    290                 295                 300                 


Pro Gln Arg Glu Ala Ser Gln Phe Ile Arg Val Glu Lys Val Glu Leu 
305                 310                 315                 320 


Thr Cys Arg Tyr Asp Asp Thr Tyr Cys Phe Ser Glu Pro Lys Arg His 
                325                 330                 335     


Leu Gly Met Phe Asn Gly Ile Leu Thr Gly Gln 
            340                 345         


<210>  499
<211>  607
<212>  PRT
<213>  Debaryomyces hansenii


<220>
<221>  MISC_FEATURE
<222>  (1)..(607)
<223>  Dhan_GLT1

<400>  499

Cys Leu Ala Ser Asp Thr Leu Val Arg Thr Ser Glu Gly Asp Lys Pro 
1               5                   10                  15      


Val Ala Glu Val Ala Ile Gly Asp Tyr Leu Leu Asp Ala Glu Asp Lys 
            20                  25                  30          


Pro Val Leu Cys Met Gly Ala Asn Pro Ser Gln Thr Gly Arg Met Lys 
        35                  40                  45              


Glu Ile Ala Tyr Gln Asp Phe Asp Ser Lys Lys Arg Val Ser Phe Lys 
    50                  55                  60                  


Cys Thr Pro Asp His His Leu Glu Leu Thr Leu Thr Asp Ser Thr Pro 
65                  70                  75                  80  


Ser Leu Ser Gly Lys Ser Val Thr Trp Phe Ser Arg Cys Thr Gly Ala 
                85                  90                  95      


His Leu Ser Glu Glu Val Ser Glu Val Tyr Leu Asp Asn Met Val Ser 
            100                 105                 110         


Ile Phe Tyr Asn Asp Leu Val Asp Ser Thr Asp Ser Ala Val Asp Lys 
        115                 120                 125             


Asp Ser Ile His Glu Ala Val Asp Leu Ala Leu Glu Asp His Tyr His 
    130                 135                 140                 


Arg Gly Asn Ser Asp Gln Tyr Ser Ile His Leu Asn Glu Tyr Ile Ser 
145                 150                 155                 160 


Arg Ile Ala Asp Lys Glu Leu Gln Asn Glu Pro Glu Phe Ile Arg Glu 
                165                 170                 175     


Cys Ile His Asp Ala Ala Asn Arg Phe Val Ile Thr Ser Ser Gly Asn 
            180                 185                 190         


Arg Asn Ile Lys Ser Glu Ser Phe Asp Asp Lys Leu Leu Leu Ser Arg 
        195                 200                 205             


Ser Arg Ser Ser Thr Ala Asp Ser Asp Ser Asp Tyr Val Ile Thr Asp 
    210                 215                 220                 


Ala Ser Val His Ser His Ser Asn Asn Ser Ser Val Tyr Leu Ala Ser 
225                 230                 235                 240 


Pro Asp Ser Met Ile Pro Asp Gly Ala Ala Asn Arg Phe Glu Asn Ile 
                245                 250                 255     


Ala Ser Lys Leu Lys Glu Pro Val Cys Asn Cys Gly Gly Ile Arg Lys 
            260                 265                 270         


Ile Phe Arg Ser Phe Gly Thr Thr Glu Asp Ala Glu Leu Ala Tyr Ser 
        275                 280                 285             


Leu Leu Leu Ser Glu His Tyr Tyr Arg Leu Asp Pro Arg Phe Val Thr 
    290                 295                 300                 


Asp Gly Tyr Thr Phe Gln Ala Ser Val Glu Gln Tyr Glu Asn Met Cys 
305                 310                 315                 320 


Ser Gln Glu Val Gln Asn Met His Leu Lys Leu Tyr Arg Ser Pro Leu 
                325                 330                 335     


Lys Phe Val Glu Arg Glu His Asn Ser Ala Glu Leu Pro Val Asp Pro 
            340                 345                 350         


Tyr Phe Leu Gly Leu Trp Leu Gly Asp Gly Asp Ser Ser Gly Thr Thr 
        355                 360                 365             


Ile Met Thr Thr Asp Arg Glu Ile Val Val Trp Leu Asn Ser Tyr Val 
    370                 375                 380                 


Glu Arg Leu Asn Gln Asn Lys Pro Glu Gly Cys Phe Pro Leu Lys Leu 
385                 390                 395                 400 


Thr Glu Gln Leu Ile Tyr Gly Ala Gly His Thr Ser Lys Ser Gly His 
                405                 410                 415     


Thr Thr Lys Val Asp Val Arg Asn Tyr Lys Ile Ser Ser Gly Asp Ala 
            420                 425                 430         


Phe Val Arg Ser Gly Thr Tyr Trp Asn Pro Ile Phe Asp Gly Leu Lys 
        435                 440                 445             


Lys Leu Gly Leu Leu Asn Asn Lys Ser Ala Gly Ile Pro Gln Glu Tyr 
    450                 455                 460                 


Met Asn Ser Asp Glu Gln Asn Arg Leu Ser Val Ile Ala Gly Leu Met 
465                 470                 475                 480 


Asp Ser Asp Gly Cys Tyr Val Lys Ser His Asn Thr Tyr Arg Phe Thr 
                485                 490                 495     


Gln Leu Thr Glu Asp His Lys Lys Ile Val Tyr Asp Leu Lys Glu Leu 
            500                 505                 510         


Ala Leu Ser Cys Gly Ile Asn Thr Thr Gly Val Glu Leu Ser Val Lys 
        515                 520                 525             


Pro Leu Gly Phe Asn Lys His Lys His Ser Thr Glu Tyr Val Val Tyr 
    530                 535                 540                 


Leu Gly Asn Gly Ser Gln Lys Phe Gln Glu Leu Leu Leu Leu Pro Arg 
545                 550                 555                 560 


Lys Lys Met Glu Ile Ser Lys Lys His Val Ser Leu Asp Ala Arg Pro 
                565                 570                 575     


Phe Thr Val Ser Asp Val Glu Asp Gly Glu Phe Arg Ala Ile Glu Val 
            580                 585                 590         


Ser Gly Gly Val Phe Gln Leu Ala Asn Arg Leu Val Val Ala Asn 
        595                 600                 605         


<210>  500
<211>  294
<212>  PRT
<213>  Frankia sp. HFPCCI3


<220>
<221>  MISC_FEATURE
<222>  (1)..(294)
<223>  Fsp-CcI3_RIR1

<400>  500

Cys Gln Pro Tyr Asp Ala Leu Val Ser Thr Pro Ser Gly Leu Val Pro 
1               5                   10                  15      


Ile Gly Ala Leu Val Glu Thr Asp Ala Val Gly Met Lys Val Phe Asp 
            20                  25                  30          


Ala His Gly Leu Thr Gln Val Ile Ala Thr Lys Ser Asn Gly Val Lys 
        35                  40                  45              


Asp Val Leu Arg Ile Trp Thr Arg Ala Gly His Ala Leu Asp Val Thr 
    50                  55                  60                  


Ala Asp His Leu Val Trp Arg Ser Thr Ser Ala Gly Ala Gly Ala Phe 
65                  70                  75                  80  


Val Pro Ala Gly Ala Leu Arg Ala Gly Asp Thr Leu Glu Trp His Arg 
                85                  90                  95      


Thr Ile Ala Pro Gly Glu Gly Glu Ile Thr Ser Arg Glu Ile Ala Glu 
            100                 105                 110         


Ala Ala Leu Ala Gly Arg Leu Gln Ala Asp Gly Phe Val Gly Arg Tyr 
        115                 120                 125             


Ala Gly Thr Asn Ala Ser Leu Thr Ile Glu Ala Met Thr Val Pro Thr 
    130                 135                 140                 


Arg Leu Tyr Asp Ala Pro Leu Pro Val Val Ala Ala Tyr Leu Arg Ser 
145                 150                 155                 160 


Leu Phe Gln Ala Asp Gly Tyr Val Ser Arg Arg Glu Arg Ser Thr Leu 
                165                 170                 175     


Ile Gly Leu Asp Met Ile Ser Glu Gly Leu Ile Arg Gly Val Gln Gly 
            180                 185                 190         


Leu Leu Ala Arg Phe Gly Ile Phe Ala Arg Val Arg Arg Glu Ala Asp 
        195                 200                 205             


Pro Arg Pro Asp Arg His Asp Leu Trp Ser Leu Gly Ile Gln Asn Ala 
    210                 215                 220                 


Gly Asp Arg Arg Thr Phe Ala Asp Glu Ile Gly Phe Leu Asp Pro Val 
225                 230                 235                 240 


Lys Ala Ala Lys Leu Glu Ala Ser Phe Asp Gln Pro Gly Gln Ala Ala 
                245                 250                 255     


Lys Pro Val Lys Arg Leu Gln Ile Glu Arg Ile Glu Pro Arg Gly Pro 
            260                 265                 270         


Met Pro Val Tyr Asp Ile Gln Thr Asp Ser Gly Glu Tyr Leu Ser Ala 
        275                 280                 285             


Gly Leu Arg Val His Asn 
    290                 


<210>  501
<211>  287
<212>  PRT
<213>  Gemmata obscuriglobus


<220>
<221>  MISC_FEATURE
<222>  (1)..(287)
<223>  Gob_Hyp

<400>  501

Cys Gln Pro Ala Gly Thr Gln Val Ala Lys Val Ile Lys Glu Gly Arg 
1               5                   10                  15      


Trp Arg Glu Asp Ser Val Ile Glu Gln Val Pro Ile Glu Ser Leu Gln 
            20                  25                  30          


Pro Gly Asp Arg Val Val Ser Phe Gly Asn Ala Lys Ile Tyr Arg Arg 
        35                  40                  45              


Gly Arg Ala Val Thr Gly Ile Thr Ser Arg Arg His Thr Gly Asn Leu 
    50                  55                  60                  


His Arg Val Glu Val Gly Glu Phe Arg Thr Arg Ala Thr Pro Glu His 
65                  70                  75                  80  


Arg Phe Thr Val Arg Phe Asp Pro Ala Arg Pro Lys Ala Gly Leu Leu 
                85                  90                  95      


Tyr Leu Met Arg Arg Gly Asp Arg Trp Arg Val Gly Val Cys Gly Met 
            100                 105                 110         


Phe Asn Ser Arg Gly Phe Gly Val Ser Val Arg Leu Ser Gln Glu Arg 
        115                 120                 125             


Gly Asp Ala Ala Trp Val Leu Gly Ala Phe Ala Thr Leu Thr Glu Ala 
    130                 135                 140                 


Arg Ile Ala Glu Gln Val Val Ser Cys Arg Tyr Gly Ile Pro Thr Thr 
145                 150                 155                 160 


Val Trp Glu Thr Gly Arg Asn Pro Gly Ala Ser Trp Ala Gln Arg Asp 
                165                 170                 175     


Gln Ala Gly Ile Asp Ala Ile Tyr Gln Arg Leu Gly Val Asp Arg Ile 
            180                 185                 190         


Arg Ala Gly Val Asp Arg Leu Leu Arg Asp His Gly Leu Ser Ala Gly 
        195                 200                 205             


Leu Pro Leu Leu Ala Ala Asn Glu Pro Gly Asn Phe Ser Cys Arg Gln 
    210                 215                 220                 


Ser Arg Gln Val Ala Ala Cys Asn Leu Val Pro Gly Val Met Gln Val 
225                 230                 235                 240 


Pro Val Pro Thr Ala Gly Glu Arg Phe Glu Trp Arg Asp Leu Thr Ala 
                245                 250                 255     


Thr Ser Phe Glu Arg Val His Asp Leu Glu Val Trp Ser Met Asp Val 
            260                 265                 270         


Glu Arg Asp Lys His Tyr Val Ala Asp Gly Ile Val Val His Asn 
        275                 280                 285         


<210>  502
<211>  412
<212>  PRT
<213>  Gloeobacter violaceus


<220>
<221>  MISC_FEATURE
<222>  (1)..(412)
<223>  Gvi_RIR1-1

<400>  502

Cys Phe Ala Ala Gly Thr Leu Leu His Thr Glu Gln Gly Tyr Val Pro 
1               5                   10                  15      


Val Glu Gln Val Val Ala Gly Val Gly Thr Arg Val Cys Thr His Gln 
            20                  25                  30          


Gly Phe Arg Asn Ile Ser Glu Arg Phe Asp Asn Gly Glu Ala Glu Val 
        35                  40                  45              


Phe Arg Val Thr Thr Arg Lys Gly Tyr Ser Val Glu Val Thr Ala Asn 
    50                  55                  60                  


His Lys Met Ala Arg Leu Asp Glu Asn Gly Asp Leu Leu Leu Asp Glu 
65                  70                  75                  80  


Leu Ser His Leu Gln Val Gly Asp Asn Leu Leu Leu Leu Leu Gly Ser 
                85                  90                  95      


Asn Pro Val Thr Glu Lys Val Arg Leu Gln Cys Ile Pro Ala Gly Tyr 
            100                 105                 110         


Arg Ser Ser Ile Glu Ile Ala Gln Pro Pro Glu Leu Asp Glu Gln Leu 
        115                 120                 125             


Ala Tyr Leu Leu Gly Tyr Ala Tyr Gly Asp Gly Cys Val Gly Arg Gly 
    130                 135                 140                 


Ala Thr Tyr Asn Tyr Leu Ser Leu Ala Val Ser His Thr Tyr Pro Asn 
145                 150                 155                 160 


Val Arg Asp Gln Leu Ala Ala Ile Ile Arg Glu Lys Phe Gly Leu Thr 
                165                 170                 175     


Thr Lys Ile Tyr Ser Gly Ser Gly Ala Val Trp Asn Leu Leu Val His 
            180                 185                 190         


Ser Ala Asn Leu Leu Asp Trp Leu Lys Ala Asn Gly Leu Leu Lys Gln 
        195                 200                 205             


Lys Ala Ala Asp Leu Ala Met Pro Glu Ala Ile Leu Arg Ser Pro Ser 
    210                 215                 220                 


Ser Val Val Gly Ala Phe Leu Ser Gly Tyr Phe Asp Ala Asp Gly Cys 
225                 230                 235                 240 


Val Arg Gly Gly Lys Gly Gly Tyr Gly Phe Asp Cys Thr Ser Lys Ala 
                245                 250                 255     


Phe Val Gly Ala Val Gln Leu Leu Leu Leu Ala Glu Gly Ile Val Ser 
            260                 265                 270         


Asn Leu His Thr Thr Asp Arg Ser Arg Gln Gly Trp Arg Thr Ile Tyr 
        275                 280                 285             


Arg Leu Asn Val Cys Gly Thr Glu Phe Lys Arg Arg Phe Gln Thr Leu 
    290                 295                 300                 


Cys Cys Arg Ser Ala Lys Val Val His Ser Pro Met Val Leu Gly Arg 
305                 310                 315                 320 


Asp Gly Thr Gly Gly Tyr Pro Pro Ala Leu Val Arg Gly Ala Ser Tyr 
                325                 330                 335     


Gln Arg Val Val Ala Val Gly Gly Lys His Leu Leu Tyr Thr Ala Leu 
            340                 345                 350         


Leu Lys Val Ile Glu Lys Thr Arg Thr Ala Gly Lys Gln Ala Leu Ala 
        355                 360                 365             


Glu Ser Leu Cys Gln His Val Asn Tyr Phe Pro Asp Pro Ile Val Ala 
    370                 375                 380                 


Ile Glu Ser Val Gly Thr Gln Arg Val Tyr Asp Ile Glu Val Glu Gly 
385                 390                 395                 400 


Met His Leu Leu Gly Asn Gly Ile Tyr Thr Ser Asn 
                405                 410         


<210>  503
<211>  492
<212>  PRT
<213>  Ectothiorhodospira halophila


<220>
<221>  MISC_FEATURE
<222>  (1)..(492)
<223>  Hhal_DnaB-1

<400>  503

Cys Leu Ala Tyr Asp Ala Glu Ile Val Gln Ala Asp Gly Gly Val Lys 
1               5                   10                  15      


Thr Ile Glu Gln Ile Val Arg Glu Arg Arg Ala His Leu Ala Thr Val 
            20                  25                  30          


Gly Ala Asp Trp Arg Leu Thr Trp Thr Glu Pro Cys Asp Tyr Val Asp 
        35                  40                  45              


Asp Gly His Lys Pro Val Phe Glu Val Thr Thr Arg Leu Gly Arg Arg 
    50                  55                  60                  


Ile Glu Thr Thr Leu Thr His Pro Phe Leu Thr Val His Gly Trp Gln 
65                  70                  75                  80  


Arg Leu Glu Asp Leu Ala Glu Gly Asp Ala Ile Gly Val Pro Arg Gln 
                85                  90                  95      


Leu Pro Val Phe Gly Gln Glu Pro Ile Arg Asp Cys Glu Val Arg Leu 
            100                 105                 110         


Leu Gly His Leu Ile Gly Asp Gly Gly Leu Thr Gly Ser Pro Pro Arg 
        115                 120                 125             


Leu Thr Ser Gly Gln Glu Ala Met Thr Ala Asp Phe Leu Glu Ala Val 
    130                 135                 140                 


Asp Ala Phe Gly Gly Val Glu Ala Lys Pro Ile Arg Ala Ser Arg Arg 
145                 150                 155                 160 


Thr Gln Ser Trp Val Val Val Gly Ala Ala Gln Ala Arg Ala Ala Ala 
                165                 170                 175     


Arg Ser Ser Phe Ala Ser Leu Val Asp Ala Leu Ile Arg Arg Ser Pro 
            180                 185                 190         


Leu Thr Gly Arg Ala Ile Ala Arg Asn Leu Gly Val Ala Pro Ala Thr 
        195                 200                 205             


Leu Thr Tyr Trp Arg Gln Gly Val Asn Val Pro Asp Ala Ala Met Val 
    210                 215                 220                 


Gly Leu Leu Ala Gly Glu Leu Gly Val Asp Val Gly Glu Leu Arg Pro 
225                 230                 235                 240 


Glu Pro Val Ala Arg Arg Asn Asp Arg Asn Pro Leu Gln Ala Trp Leu 
                245                 250                 255     


Asp Arg Leu Gly Leu Ala Gly Lys Ser Ala His Glu Lys Thr Val Pro 
            260                 265                 270         


Asp Cys Val Phe Arg Leu Pro Arg Glu Gln Leu Ala Arg Phe Leu Asn 
        275                 280                 285             


Arg Leu Phe Ser Ser Asp Gly Trp Val Thr His Leu Ala Ser Gly Gln 
    290                 295                 300                 


Gly Gln Ile Gly Tyr Thr Thr Val Ser Glu Ala Leu Ala Arg Gln Ile 
305                 310                 315                 320 


Gln His Leu Leu Leu Arg Phe Gly Val Leu Ala Lys Leu Arg His Arg 
                325                 330                 335     


Ser Val Arg Tyr Gln Asp Gly Arg Arg Pro Ala Trp Gln Leu Asp Ile 
            340                 345                 350         


Thr His Ala Glu Ser Ile Leu Thr Phe Ala Glu Gln Ile Gly Ile Leu 
        355                 360                 365             


Gly Lys Glu Gln Arg Leu Ala Ser Val Ala Ala Ser Val Arg Gly Arg 
    370                 375                 380                 


Arg Arg Gln Ser His Thr Asp His Ile Pro Cys Glu Ile Trp Gln Phe 
385                 390                 395                 400 


Ile Asp Arg Ala Arg Gly Glu Trp Thr Trp Ala Glu Leu Ala Arg Arg 
                405                 410                 415     


Ala Gly Val Ala Ser Ser Asn Ile His Ala Tyr Arg Arg Gly Met Ser 
            420                 425                 430         


Arg Gln Arg Leu Ala Ala Phe Ala Asp Ala Leu Gly Ser Arg Glu Leu 
        435                 440                 445             


Arg Gln Leu Ala Ser Ser Asp Leu Tyr Trp Asp Arg Ile Ala Ser Ile 
    450                 455                 460                 


Arg Pro Leu Gly His Lys Gln Val Tyr Asp Leu Thr Ile Pro Glu Thr 
465                 470                 475                 480 


His Asn Phe Ile Ala Asn Asp Val Cys Val His Asn 
                485                 490         


<210>  504
<211>  477
<212>  PRT
<213>  Haloarcula marismortui


<220>
<221>  MISC_FEATURE
<222>  (1)..(477)
<223>  Hma_CDC21

<400>  504

Cys Val His Gly Asp Thr Arg Val Thr Leu Ala Asp Gly His Glu Arg 
1               5                   10                  15      


Pro Ile Arg Glu Val Val Glu Ser Asn Leu Asp Asp Pro Lys Pro Val 
            20                  25                  30          


Asp Asp Gly Val Trp Asp Thr Val Asp Phe Asp Val Pro Ser Leu Gln 
        35                  40                  45              


Ser Asp Gly Thr Val Ala Thr Gln Asn Ala Thr Lys Val Trp Lys Arg 
    50                  55                  60                  


Lys Ala Pro Glu Thr Leu Tyr Arg Ile Arg Thr Ala Thr Gly Arg Glu 
65                  70                  75                  80  


Leu Asp Val Thr Pro Ser His Pro Leu Phe Val Gln Ser Asp Gly Arg 
                85                  90                  95      


Phe Gln Ala Arg Lys Ala Glu Glu Leu Glu Ser Gly Thr His Val Ala 
            100                 105                 110         


Val Pro Arg Lys Val Ser Thr Asn Ala Cys Asn Glu Leu Asp Val Thr 
        115                 120                 125             


Phe Arg Gln Ser Gln Ala His Asn Arg Ile Asp Leu Asp Leu Pro Pro 
    130                 135                 140                 


Gln Trp Thr Pro Glu Leu Ala Arg Leu Ile Gly Tyr Ile Val Ala Glu 
145                 150                 155                 160 


Gly Tyr Val Glu Gln Arg Pro Asp Asn Thr Gly Tyr Val Ser Ile Thr 
                165                 170                 175     


Asn Asn Asp Arg Glu Val Leu Asp Asp Ala Lys Ser Val Leu Glu Thr 
            180                 185                 190         


Leu Asn Leu Asn Val Thr Glu Arg Ser Ser His Glu Gly Lys Thr Ala 
        195                 200                 205             


Arg Glu Leu Leu Cys Ser Ala Gly Glu Phe Val Ser Phe Leu Ala Ser 
    210                 215                 220                 


Leu Asp Glu Thr Leu Leu Gln Ser Ser Ala Glu Arg Arg Val Pro Gln 
225                 230                 235                 240 


Asp Ile Met Arg Ala Ser Asp Asn Val Val Thr Gly Phe Ile Arg Gly 
                245                 250                 255     


Tyr Ile Glu Gly Glu Gly His Val Ser Thr Ser Gln Arg Glu Ile Thr 
            260                 265                 270         


Val Ala Ser Met Ser Lys Pro Leu Leu Glu Asp Val Arg Thr Leu Leu 
        275                 280                 285             


Val Thr Gln Gly Ile Thr Ala Gln Leu Gln Pro Arg Asn Asn Gly Ser 
    290                 295                 300                 


Tyr Arg Leu Arg Ile Ser Gly Gln Ser Phe His Asp Tyr Ala Glu Gln 
305                 310                 315                 320 


Ile Gly Phe Ile Thr Ala Arg Lys Thr Glu Ala Cys Arg Gln Phe Glu 
                325                 330                 335     


Gly Thr His Gly Asn Thr Asn Leu Asp Ile Val Pro Asn Leu Gly Pro 
            340                 345                 350         


Glu Leu Arg Arg Ile Arg Glu Ala Leu Gly Leu Thr Gln Ser Glu Cys 
        355                 360                 365             


Gly Leu Pro Arg Ser Thr Tyr Gln His Tyr Glu Arg Gly Arg Arg Asn 
    370                 375                 380                 


Pro Ser Arg Asp Ser Leu Glu Ser Val Leu Asp Ala Phe Glu Thr Arg 
385                 390                 395                 400 


Leu Ala Glu Met Asn Asn Asp Thr Pro Ile Ser Asp Thr Ala Arg Ser 
                405                 410                 415     


Asp Gly Gly Gly Thr Gly Ser Leu Arg Gln Asp Leu Asn Gly Leu Ala 
            420                 425                 430         


Ala Leu Val Glu Gly Asp Ile Ala Trp Asp Arg Ile Glu Ser Ile Glu 
        435                 440                 445             


Pro Ile Glu His Asp Glu Lys Trp Val Tyr Asp Leu Glu Ile Glu Gly 
    450                 455                 460                 


Thr His Asn Tyr Leu Thr Asn Gly Val Val Ser His Asn 
465                 470                 475         


<210>  505
<211>  209
<212>  PRT
<213>  Haloquadratum walsbyi DSM 16790


<220>
<221>  MISC_FEATURE
<222>  (1)..(209)
<223>  Hwa_MCM-1

<400>  505

Cys Val Ser Gly Glu Thr Asp Ile Ala Leu Val Glu Gly Lys Thr Ala 
1               5                   10                  15      


Thr Ile Gly Glu Leu Val Glu Ser Ala Leu Thr Asp Pro Lys Pro Val 
            20                  25                  30          


Asp Asp Gly Val Trp Asp Thr Ala Asp Phe Thr Val Thr Ser Ala Ile 
        35                  40                  45              


Glu Thr Gly Glu Leu Ile Glu Arg Asp Val Thr Arg Val Trp Lys Arg 
    50                  55                  60                  


Gln Ser Pro Glu Thr Met Arg Gln Ile Gln Ile Ala Gly Gly Arg Ser 
65                  70                  75                  80  


Val Thr Val Thr Pro Ser His Pro Val Phe Val Glu His Asn Gly Ser 
                85                  90                  95      


Tyr Thr Ala Arg Arg Ala Asp Ser Leu Ser Ala Gly Glu Ser Val Ala 
            100                 105                 110         


Ile Ala Asp Asp Val Ala Asp Ser His Pro Ile Ser Val Asp Asn Thr 
        115                 120                 125             


Ala Asn Thr Leu Asn Pro Arg Ser Met Ser Thr Pro Gly Ile Thr Thr 
    130                 135                 140                 


Asp Gly Gly Leu Tyr Arg Thr Gly Ser Asp Gly Gly Ile Val His Ala 
145                 150                 155                 160 


Glu Val Gly Lys Glu Asp Val Thr Asp Cys Leu Thr Thr Asp Arg Ile 
                165                 170                 175     


Thr Ala Val Lys Thr Val Thr Pro Thr Ala Glu Trp Val Tyr Asp Leu 
            180                 185                 190         


Glu Val Glu Gly Thr His Ala Tyr Leu Thr Asn Gly Val Leu Ser His 
        195                 200                 205             


Asn 
    


<210>  506
<211>  358
<212>  PRT
<213>  Haloquadratum walsbyi DSM 16790


<220>
<221>  MISC_FEATURE
<222>  (1)..(358)
<223>  Hwa_PolB-2

<400>  506

Cys Phe Thr Pro Asp Thr Asn Val Leu Thr Pro Asn Gly Val Arg Asn 
1               5                   10                  15      


Ile Arg Asp Leu Thr Val Gly Asp Ser Val Tyr Ser Leu Asn Pro Glu 
            20                  25                  30          


Thr Met Gln Met Glu Ile Lys Pro Val Thr Gln Thr His Glu Tyr Pro 
        35                  40                  45              


Asp Tyr Gln Gly Asp Leu Ile Asp Ile Gln Thr Asn Glu Ile Asp Phe 
    50                  55                  60                  


Arg Val Thr Pro Asn His Arg Met Leu Val Glu Ala Thr Gly Thr Asp 
65                  70                  75                  80  


Thr Thr Ser Thr Asn Asp Tyr Asp Phe Ile Glu Ala Gly Asn Leu Asp 
                85                  90                  95      


Ile Ser Ser Arg Tyr Glu Leu Pro His Gly Trp Ser Val Asp His Thr 
            100                 105                 110         


Asp Ser Leu Gly Ala Tyr Ile Asp Leu Ile Thr Leu Leu Arg Glu Gln 
        115                 120                 125             


Ser Asp Thr Tyr Asn Val Leu Ser Asp Gly Gly Met Thr Thr Ala Ala 
    130                 135                 140                 


Thr Ala Asp Ile Asn His Asn Asn Val Thr Arg Arg Val Asp Ser Asp 
145                 150                 155                 160 


Thr Phe Val Ser Leu Ile Gly Trp Tyr Val Ala Thr Gly Arg Val Ser 
                165                 170                 175     


Arg Thr Gln Asn Gly Ser Asp Arg Val Tyr Leu Gln Leu Ser Gln Thr 
            180                 185                 190         


Asn Thr Lys Ala Arg Thr Gln Leu Thr Met Leu Leu Asp Glu Leu Gly 
        195                 200                 205             


Val Asp Trp Gln Ala Asp Asn Glu Lys Ile His Phe Val Ser His Val 
    210                 215                 220                 


Trp Thr Glu Leu Phe Asp Thr Thr Cys Gly Arg Thr Glu Lys Asn Lys 
225                 230                 235                 240 


His Ile Pro Glu Leu Ile Phe Asp Ala Ser Ala Ser Gln Lys Arg Ala 
                245                 250                 255     


Phe Phe Asp Ala Ile Ile Asn Gly Ser Gly Val Lys Asn Asp Asp Ser 
            260                 265                 270         


Tyr Gln Tyr His Thr Ser Ser Glu Asp Leu Arg Asp Asp Ile Leu Arg 
        275                 280                 285             


Leu Cys Val His Ile Gly Ile Val Ala Arg Tyr Asp Tyr Ile Asn Asp 
    290                 295                 300                 


Glu Ser Trp Arg Ile Glu Cys Thr Glu Thr Ala Asn Pro Asp Phe Thr 
305                 310                 315                 320 


Leu Thr His Ser Gly Arg Gln Ser Thr Ala Glu Asp Gly Val Tyr Cys 
                325                 330                 335     


Val Thr Val Ala Asp Asn Gln Thr Leu Leu Ala Gly Arg Asn Gly Thr 
            340                 345                 350         


Phe Gln Trp Thr Gly Asn 
        355             


<210>  507
<211>  408
<212>  PRT
<213>  Haloquadratum walsbyi DSM 16790


<220>
<221>  MISC_FEATURE
<222>  (1)..(408)
<223>  Hwa_RIR1-1

<400>  507

Cys Leu Thr Ala Asp Ser Thr Val Met Leu Lys Glu Lys Gly Met Val 
1               5                   10                  15      


Ser Val Ser Glu Val Glu Thr Gly Asp Gln Ile Ala Gln Arg Ser Asp 
            20                  25                  30          


Thr Gly Phe Gln Tyr Lys Pro Val Glu Glu Thr His Ala Tyr Glu Asn 
        35                  40                  45              


Ala Glu Thr Leu Thr Val Thr Leu Thr Asn Gly Cys Ser Ile Arg Gly 
    50                  55                  60                  


Thr Pro Asn His Arg Leu Met Val Asp Asp Glu Trp Thr Arg Ile Asp 
65                  70                  75                  80  


Glu Ile Gln Pro Asp Gln Glu Val His Tyr Thr Leu Gly Trp Leu Arg 
                85                  90                  95      


Glu Thr Asn Gln Ser Pro Pro Lys Leu His Ser Gln Ser His Thr Thr 
            100                 105                 110         


Val Asn Gln Thr Ala Asp Ser Ile Ser Pro Asp Ser Ser Glu Pro Ile 
        115                 120                 125             


Glu Leu Ser Glu Ser Glu Asn Ala Asp Thr Gly Asn Arg His Asn Ser 
    130                 135                 140                 


Ala Val Ala Val Lys Gln Ser Arg Thr Gln Thr Gln Leu Ile Ser Asp 
145                 150                 155                 160 


Glu Val Val Ser Arg Pro Glu His Thr Arg Arg Pro Asp Gln Leu Ser 
                165                 170                 175     


Glu Glu Leu Ala Glu Leu Leu Gly Leu Trp Ile Asp Thr Gly Leu Trp 
            180                 185                 190         


His Gln Ser Gly Val Gln Phe Asn Val Glu Arg Glu Asn Ile Ala Glu 
        195                 200                 205             


Tyr Ile Asp Gln Leu Ser Gln Gln Leu Phe Asp Thr Pro Ala Ala Ile 
    210                 215                 220                 


Ser Asp Thr Asp Gly Thr Tyr Thr Val Asp Ile Thr Asp His Lys Leu 
225                 230                 235                 240 


Lys Glu Trp Trp Lys Ala Asn Phe Gly Gly Lys Pro Asp Gly Thr Gln 
                245                 250                 255     


Ser Ser Tyr Val Pro Gln Met Ile Lys Glu Ala Pro Thr Asn Val Ile 
            260                 265                 270         


Glu Ala Phe Leu Arg Gly Cys Phe Thr Ala Glu Gly Gly Leu Arg Lys 
        275                 280                 285             


Asp Met Arg Pro Arg Leu Cys Thr Ser Ser Glu Asp Ser Ile Asp Asp 
    290                 295                 300                 


Ile Ala Val Leu Met Met Gly Leu Gly Tyr Pro Val Glu Lys Ser Val 
305                 310                 315                 320 


Ile Arg Asn Ala Asp Gly Glu Pro Tyr Tyr Ser Val Met Pro Ala Thr 
                325                 330                 335     


Asp Asp Gly Leu Ser Ala Phe Leu His Asp Val Gly Phe Ile Asp Glu 
            340                 345                 350         


Arg Arg Glu Ile Gly Leu Ser Asn Ile Glu Ser Ser Asp Ser Arg Ala 
        355                 360                 365             


Leu Asn Asn Thr His Lys Ile Glu Val Glu Ser Ile Val Glu Ser Pro 
    370                 375                 380                 


Pro Ala Thr Val Tyr Asp Ile Thr Val Ala Asp Asn His Glu Tyr Val 
385                 390                 395                 400 


Thr Asp Gly Ile Ile Ser His Asn 
                405             


<210>  508
<211>  438
<212>  PRT
<213>  Haloquadratum walsbyi DSM 16790


<220>
<221>  MISC_FEATURE
<222>  (1)..(438)
<223>  Hwa_RIR1-2

<400>  508

Cys Val Glu Glu Asn Ser Leu Val Ser Thr Asp Glu Gly Leu Arg Pro 
1               5                   10                  15      


Ile Lys Asp Leu Asp Asn Thr Thr Ala Glu Phe Glu Gln Trp Asp Glu 
            20                  25                  30          


Ile Asp Val Gly Val Thr Thr Asp Gly Gly Thr Lys Thr Ala Thr Ala 
        35                  40                  45              


Val Tyr Asp Asn Gly Phe Ala Asn Val Arg Gln Ile Gln Thr Glu Ser 
    50                  55                  60                  


Gly Phe Asn Ile Ala Ala Thr Pro Asn His Arg Phe Arg Thr Leu Ser 
65                  70                  75                  80  


Ser Asp Gly Thr Tyr Thr Trp Lys Glu Ala Gly Lys Phe Glu Ser Gly 
                85                  90                  95      


Asp Arg Val Ile Leu Gln Arg Asn Thr Phe Asp Ala Gly Ser Arg Val 
            100                 105                 110         


Ser Leu Glu Ala Asn Glu Arg Ala Asp Asp Ala Gln Asp Thr Thr Glu 
        115                 120                 125             


Gly Pro Glu Leu Pro Gly Arg Met Thr Ser Glu Leu Ala Glu Phe Leu 
    130                 135                 140                 


Gly Tyr Phe Met Gly Ser Gly Tyr Ile Ser Asp Glu Thr His Ala Ser 
145                 150                 155                 160 


Val Asp Leu Val Val Asp Ser Asp Ala Thr Glu Leu Asn Ser Tyr Leu 
                165                 170                 175     


Ser Asn Leu Gly Glu Gln Leu Phe Arg Ile Thr Pro Ala Val Glu Ser 
            180                 185                 190         


Gln Glu Met Ser Gln Val Leu Ser Phe Arg Asp Cys His Leu Ser Arg 
        195                 200                 205             


Tyr Phe Glu Asp Asn Gly Trp Lys Lys Thr Asp Thr Gly His Asn Gly 
    210                 215                 220                 


Asp Ala Ser Ala Ala Phe Val Pro Glu Gln Ile Leu Glu Gly Asp Glu 
225                 230                 235                 240 


Gln Val Val Asn Gly Phe Leu Arg Gly Val Phe Glu Ala Ile Gly Thr 
                245                 250                 255     


Val Ser Glu Lys Ile Glu Ile Leu Thr Thr Ser Thr Thr Leu Ala Asp 
            260                 265                 270         


Gln Leu Gln Ser Leu Leu Leu Ser Leu Gly His Val Phe Thr Arg Asp 
        275                 280                 285             


Ser Thr Lys Leu Val Glu Thr Asn Asn Tyr His Asp Asp Gln Leu Arg 
    290                 295                 300                 


Gln Arg Leu Cys Gly Ala Thr Arg Arg Glu Asp Glu Arg Phe Met Asn 
305                 310                 315                 320 


Glu Ile Gly Ser Leu Ile Glu Pro Asp Glu Leu Asn Leu Ser Thr Arg 
                325                 330                 335     


Ala Asp Lys Asn Asp Thr Tyr Pro Ser Ser Val Ile Asp His Val Gln 
            340                 345                 350         


Thr Leu Asp Gly Tyr Asp Ser Val Ser Glu Ser Leu Lys Ser Arg Ile 
        355                 360                 365             


Asn Gln Ser Gln Val Asp Gly Thr Val Ser Arg Lys Leu Ile Lys Asp 
    370                 375                 380                 


Ile Glu Ala Glu Thr Ala Glu Thr Val Ser Ile Ala Asp His Glu Leu 
385                 390                 395                 400 


Thr Gly Phe Tyr Ala Ala Thr Val Glu Ser Val Thr Glu Asp Thr Ala 
                405                 410                 415     


Tyr Thr Lys Asp Ile Ser Val Pro Ser Asn Asn Thr Tyr Ile Ala Asp 
            420                 425                 430         


Gly Phe Val Thr His Asn 
        435             


<210>  509
<211>  214
<212>  PRT
<213>  Haloquadratum walsbyi DSM 16790


<220>
<221>  MISC_FEATURE
<222>  (1)..(214)
<223>  Hwa_rPol_App

<400>  509

Ser Ile Glu Ala Asp Glu Ser Ile Val Ile Arg Arg Asp Gly Glu Thr 
1               5                   10                  15      


Glu Leu Thr Glu Ile Gly Ser Phe Val Asp Thr Ile Leu Ala Ala Asp 
            20                  25                  30          


Asn Gln Glu Thr Arg Ile Thr Asp Gly His Glu Ile Ala Leu Ala Pro 
        35                  40                  45              


Asn Gly Leu Glu Val Pro Ser Leu Asp Thr Asp Glu Gln Ile Arg Trp 
    50                  55                  60                  


Lys His Ile Glu Ala Val Ser Arg His Ala Ser Pro Asp Glu Ile Leu 
65                  70                  75                  80  


Leu Ile Glu Leu Glu Ser Gly Arg Ser Ile Arg Ala Thr Lys Ala His 
                85                  90                  95      


Ser Phe Val Thr Arg Arg Asp Gly Asp Val Leu Pro Val Ala Gly Glu 
            100                 105                 110         


Thr Leu Val Val Gly Asp Val Leu Pro Thr Val Gly Ser Tyr Asp His 
        115                 120                 125             


Ala Ser Gly Ser Ile Ser Val Pro Leu Gln Ser Gln Ser Val Ala Ala 
    130                 135                 140                 


Asp Gly Gly Thr Val Glu Pro Asn Thr Asn Ile Thr Ala Asn Ala Glu 
145                 150                 155                 160 


Arg Asp Ser Ala Ser Ile Thr Ser Ala Gly Ile Ile Gly Ser Ala Thr 
                165                 170                 175     


Trp Glu Arg Ile Ser Ser Ile Glu Thr Val Ala Pro Glu Tyr Glu Tyr 
            180                 185                 190         


Val Tyr Asp Leu Ser Val Ser Gly Leu Glu Thr Phe Thr Thr Gly Glu 
        195                 200                 205             


Gly Val Val Thr His Asn 
    210                 


<210>  510
<211>  428
<212>  PRT
<213>  Kineococcus radiotolerans SRS30216


<220>
<221>  MISC_FEATURE
<222>  (1)..(428)
<223>  Kra_DnaB

<400>  510

Cys Leu Thr Ala Gly Thr Arg Val Leu Arg Ala Asp Thr Gly Ala Glu 
1               5                   10                  15      


Thr Thr Met Gly Glu Leu Phe Ala Leu Gln Ala Arg Asp Val Pro Val 
            20                  25                  30          


Trp Ser Leu Asp Glu Ser Leu Arg Tyr Val Arg Arg His Leu Thr Arg 
        35                  40                  45              


Val Phe Pro Thr Gly Val Lys Pro Val Phe Arg Leu Arg Thr Ala Ser 
    50                  55                  60                  


Gly Lys Thr Val Arg Ala Thr Ala Asn His Pro Phe Leu Thr Tyr Asp 
65                  70                  75                  80  


Gly Trp Lys Pro Leu Gly Glu Leu Ser Val Ala Asp Arg Leu Ala Val 
                85                  90                  95      


Pro Arg His Val Pro Ala Pro Glu Arg Val Ala Ser Trp Thr Asp Asp 
            100                 105                 110         


Gln Val Leu Leu Leu Gly His Leu Ile Gly Asp Gly Ser Phe Val Lys 
        115                 120                 125             


Arg Gln Pro Leu Arg Tyr Ala Ser Val Asp Glu Ala Asn Leu Ser Ala 
    130                 135                 140                 


Val Thr Glu Ala Ala Ala Asn Ala Phe Ser Ile Val Ala Val Arg Asp 
145                 150                 155                 160 


Glu Tyr Ala Ala Ala Arg Cys Thr Thr Leu Arg Leu Pro Ala Pro Tyr 
                165                 170                 175     


Arg Leu Thr His Gly Arg Arg Asn Pro Leu Ala Ala Trp Leu Asp Glu 
            180                 185                 190         


Leu Gly Leu Phe Gly Leu Arg Ser Tyr Glu Lys Phe Val Pro Gln Glu 
        195                 200                 205             


Val Phe His Leu Pro Lys Arg Gln Ile Ala Leu Phe Leu Arg His Leu 
    210                 215                 220                 


Trp Ala Thr Asp Gly Ser Val Thr Leu Thr Arg Gln Ser Arg Gly Gly 
225                 230                 235                 240 


Arg Ile Tyr Tyr Ala Ser Thr Ser Leu Gln Leu Ile Gln Asp Val Ser 
                245                 250                 255     


Arg Leu Leu Leu Arg Phe Gly Ile Ser Thr Arg Val Arg Thr Thr Thr 
            260                 265                 270         


Pro Lys Gly Asp His Arg Pro Gly Tyr Thr Leu Asp Val Ser Gly Val 
        275                 280                 285             


Asp Asp Gln Arg Arg Phe Leu Gln Glu Ile Gly Val His Gly Ala Arg 
    290                 295                 300                 


Gly Ala Thr Ala Asp Arg Leu Leu Glu Val Ile Arg Asp Val Ser Ala 
305                 310                 315                 320 


Asn Thr Asn Val Asp Thr Val Pro Arg Gln Val Trp Asp Asp Val Arg 
                325                 330                 335     


Arg Leu Leu Val Glu Lys Glu Met Thr His Arg Glu Phe Ala Ala Ala 
            340                 345                 350         


Met Gly Thr Ser Phe Gly Gly Ser Ser Leu Trp Lys His Ala Pro Ser 
        355                 360                 365             


Arg Glu Arg Leu Gly Arg Val Ala Gln Val Leu Asp Ser Ala Glu Leu 
    370                 375                 380                 


Asp Val Leu Ala Val Asn Asp Val Leu Trp Asp Glu Val Val Ala Ile 
385                 390                 395                 400 


Glu Pro Asp Gly Glu Glu Gln Val Tyr Asp Ala Thr Val Leu Gly Gly 
                405                 410                 415     


His Asn Phe Val Ala Asp Gly Ile Ala Val His Asn 
            420                 425             


<210>  511
<211>  380
<212>  PRT
<213>  Methylococcus capsulatus


<220>
<221>  MISC_FEATURE
<222>  (1)..(380)
<223>  Mca_RIR1

<400>  511

Cys Val Thr Ala Asp Thr Trp Val Met Thr Ala Ser Gly Ala Arg Gln 
1               5                   10                  15      


Val Arg Asp Leu Ile Asp Arg Pro Phe Glu Ala Val Val Asp Gly Glu 
            20                  25                  30          


Cys His Pro Thr Glu Ser Arg Gly Phe Phe Phe Thr Gly Asp Lys Pro 
        35                  40                  45              


Val Leu Arg Leu Ser Thr Ala Glu Gly His Thr Leu Arg Leu Thr Ala 
    50                  55                  60                  


Asn His Pro Val Leu Arg Val Ser Lys Met Thr Arg Gln Leu Arg Glu 
65                  70                  75                  80  


Thr Glu Trp Val Lys Ala Gly Glu Leu Arg Pro His Asp Lys Ile Val 
                85                  90                  95      


Leu His Asp His Arg Ala Leu Pro Ser Trp Asp Gly Ala His Thr Glu 
            100                 105                 110         


Ala Glu Gly Tyr Leu Ile Gly Leu Leu Ile Gly Gly Gly Thr Leu Thr 
        115                 120                 125             


Arg Asp Lys Ala Ile Leu Ser Ile Trp Asp Ala Ala Ala Pro Lys Val 
    130                 135                 140                 


Ala Asn Gly Gly Gly Ser Val Pro Ala Ala Gly Val Ala Gly Val Met 
145                 150                 155                 160 


Arg Ala Ala Glu Leu Ala Ala Arg Thr Leu Pro His Arg Thr Asp Phe 
                165                 170                 175     


Asn Gly Trp Gln Thr Thr Met Glu Gly Arg Gly Glu Tyr His Met Ala 
            180                 185                 190         


Thr Gly Ala Leu His Thr Leu Ala Leu Glu Leu Gly Leu Thr Pro Gly 
        195                 200                 205             


Asp Lys Arg Leu Thr Ala Pro Leu Glu Thr Thr Ser Ser Ala Phe His 
    210                 215                 220                 


Arg Gly Leu Leu Arg Gly Met Phe Asp Ala Asp Gly Ser Val Gln Gly 
225                 230                 235                 240 


Ser Gln Arg Lys Gly Val Ser Ile Arg Leu Pro Gln Thr Asp Leu Gly 
                245                 250                 255     


Asn Leu Gln Thr Val Gln Arg Met Leu Leu Arg Leu Gly Val Ala Ser 
            260                 265                 270         


Thr Ile His Gln Asn Arg Arg Pro Gly Gly Thr Lys Val Leu Pro Asp 
        275                 280                 285             


Gly Glu Gly Gly Ala Lys Gly His Ser Cys Gln Ala Ala His Glu Leu 
    290                 295                 300                 


Ile Ile Ser Gly Glu Asn Val Val Arg Tyr Ala Glu Arg Ile Gly Phe 
305                 310                 315                 320 


Ala Asp Ser Asp Lys Met Asp Arg Leu Thr Ala Leu Leu Gln Arg Tyr 
                325                 330                 335     


Arg His Thr Arg His Ala Glu Arg Phe Ile Ala Thr Val Gln Ser Leu 
            340                 345                 350         


Glu Asp Asp Gly Met Glu Ala Val Tyr Asp Val Thr Val Ala Asp Val 
        355                 360                 365             


His Ala Phe Asp Ala Asn Gly Leu Tyr Val His Asn 
    370                 375                 380 


<210>  512
<211>  165
<212>  PRT
<213>  Methanoculleus marisnigri


<220>
<221>  MISC_FEATURE
<222>  (1)..(165)
<223>  Memar_Pol-II

<400>  512

Cys Phe Ala Gly Asp Thr Glu Ile Thr Val Ser Asp Gly Arg Arg Trp 
1               5                   10                  15      


Met Ser Leu Pro Ile Arg Gln Phe Val Thr Glu Asn Phe Asp Ile Ser 
            20                  25                  30          


Lys Pro Gly Leu Asp His Val Gly Thr Phe Tyr Ser Asp Pro Arg Gln 
        35                  40                  45              


Pro Phe Tyr Val Arg Ser Ile Asp Ser Gln Gly Lys Thr Ser Leu Lys 
    50                  55                  60                  


Arg Val Thr Ser Val Ser Val His Arg Ala Pro Ala His Leu Val Arg 
65                  70                  75                  80  


Phe Ala Thr Arg Arg Gly Arg Val Leu Thr Val Thr Pro Asp His Ala 
                85                  90                  95      


Met Leu Val Trp Asp Thr Asp Tyr Leu Arg Lys Ile Lys Ala Leu Glu 
            100                 105                 110         


Val Ala Val Gly Asp Arg Val Pro Val Glu Glu Gly Gly Leu Val Val 
        115                 120                 125             


Ala Asp Glu Val Val Ser Arg Glu Thr Val Gln Ala Leu Asp Asp Arg 
    130                 135                 140                 


Val Tyr Cys Leu Thr Val Ala Glu Asn His Thr Leu Val Ala Asn Gly 
145                 150                 155                 160 


Ile Phe Cys Gly Gln 
                165 


<210>  513
<211>  270
<212>  PRT
<213>  Methylobacterium extorquens


<220>
<221>  MISC_FEATURE
<222>  (1)..(270)
<223>  Mex_helicase

<400>  513

Cys Phe Ala Ala Gly Thr Leu Ile Lys Thr Pro Lys Gly Pro Val Pro 
1               5                   10                  15      


Ile Glu Gln Ile Gln Ser Gly Asp Leu Val Phe Asn Ala Ile Gly Ile 
            20                  25                  30          


Gly Val Val Glu Gly Ile Val Cys Gln Gln Lys Gln Thr Ile Thr Leu 
        35                  40                  45              


Glu Leu Ser Asp Gly Thr Ser Ile Val Cys Thr His Asp His Pro Phe 
    50                  55                  60                  


Phe Cys Pro Arg Gly Trp Val Ala Ala Gly Asp Leu Glu Val Gly Ser 
65                  70                  75                  80  


Gly Leu Phe Ser His Glu Asp Leu Arg Arg Leu Trp Ser Gly Gly Ala 
                85                  90                  95      


Ser Leu Gly Leu Glu Ser Gly Ser Ser Asp Gly Arg Gly Ala Val Arg 
            100                 105                 110         


Ser Ser Glu Val Leu Leu Arg Ile Leu Arg Glu Glu Ala Arg Glu Pro 
        115                 120                 125             


Asp Ala Gly Tyr Cys Gly Pro Ala Glu Asp Val Arg Asn Ala Ser Thr 
    130                 135                 140                 


Asp Arg Ala His Ala Glu Gly Ala Trp Trp Gln Trp Gln Ala Asp Pro 
145                 150                 155                 160 


Ile Ala Ser Asp Glu Ala Ala Arg Ser Ala Gly Arg Arg Val Ala Asp 
                165                 170                 175     


Arg Val Arg Asp Glu Asp Arg Arg Glu Ala Arg Pro Glu Pro Thr Ala 
            180                 185                 190         


Val Leu Leu Gln Asp Arg His Cys Glu Pro Leu Ala Asn Asp Arg Asn 
        195                 200                 205             


Arg Ser Gly Arg Glu His Ser Ser Arg Gly Thr Gly Glu Ala Glu Gly 
    210                 215                 220                 


Gln Arg Gln Gly Asp Val Pro Cys Ser Val Arg Val Val Ser Ile Ser 
225                 230                 235                 240 


Arg Glu Glu Arg Gly Gly Pro Glu Ala Val Tyr Asn Leu Arg Val Ser 
                245                 250                 255     


Gly His Pro Ser Tyr Phe Ala Gly Gly Val Leu Val His Asn 
            260                 265                 270 


<210>  514
<211>  165
<212>  PRT
<213>  Methanospirillum hungatei


<220>
<221>  MISC_FEATURE
<222>  (1)..(165)
<223>  Mhu_Pol-II

<400>  514

Cys Phe His Gly Asp Thr Leu Ile Glu Ile Tyr Ala Asp Gly Ile Leu 
1               5                   10                  15      


Glu Glu Ile Pro Ile Arg Arg Phe Val Leu Glu His Leu Asp Leu Ser 
            20                  25                  30          


Gln Ala Gly Val Asp Ala Leu Gly Thr Phe Tyr Ala Asp Pro Val Arg 
        35                  40                  45              


Pro Ala His Val Arg Ser Val Asp Thr Gly Gly Ile Pro His Leu Arg 
    50                  55                  60                  


Lys Ile Thr Ser Val Ser Val His Lys Ala Pro Ala Asn Leu Ile Gln 
65                  70                  75                  80  


Phe Ser Thr Ser Arg Gly Lys Asn Leu Leu Val Thr Pro Asp His Ala 
                85                  90                  95      


Met Leu Val Trp Asp Val Ser Tyr Leu Arg Lys Ile Arg Ala Leu Glu 
            100                 105                 110         


Val Lys Ile Gly Asp Ala Val Pro Val Trp Glu Ser Gly Val Val Ile 
        115                 120                 125             


Ser Asp Arg Ile Val Ser Ile Asp Tyr Val Pro Cys Glu Asp Glu Arg 
    130                 135                 140                 


Val Tyr Cys Leu Thr Val Asp Arg Asp His Asn Val Val Gly Asn Gly 
145                 150                 155                 160 


Ile Phe Thr Gly Gln 
                165 


<210>  515
<211>  168
<212>  PRT
<213>  Methanococcus jannaschii


<220>
<221>  MISC_FEATURE
<222>  (1)..(168)
<223>  Mja_Klba

<400>  515

Ala Leu Ala Tyr Asp Glu Pro Ile Tyr Leu Ser Asp Gly Asn Ile Ile 
1               5                   10                  15      


Asn Ile Gly Glu Phe Val Asp Lys Phe Phe Lys Lys Tyr Lys Asn Ser 
            20                  25                  30          


Ile Lys Lys Glu Asp Asn Gly Phe Gly Trp Ile Asp Ile Gly Asn Glu 
        35                  40                  45              


Asn Ile Tyr Ile Lys Ser Phe Asn Lys Leu Ser Leu Ile Ile Glu Asp 
    50                  55                  60                  


Lys Arg Ile Leu Arg Val Trp Arg Lys Lys Tyr Ser Gly Lys Leu Ile 
65                  70                  75                  80  


Lys Ile Thr Thr Lys Asn Arg Arg Glu Ile Thr Leu Thr His Asp His 
                85                  90                  95      


Pro Val Tyr Ile Ser Lys Thr Gly Glu Val Leu Glu Ile Asn Ala Glu 
            100                 105                 110         


Met Val Lys Val Gly Asp Tyr Ile Tyr Ile Pro Lys Asn Asn Thr Ile 
        115                 120                 125             


Asn Leu Asp Glu Val Ile Lys Val Glu Thr Val Asp Tyr Asn Gly His 
    130                 135                 140                 


Ile Tyr Asp Leu Thr Val Glu Asp Asn His Thr Tyr Ile Ala Gly Lys 
145                 150                 155                 160 


Asn Glu Gly Phe Ala Val Ser Asn 
                165             


<210>  516
<211>  412
<212>  PRT
<213>  Methanococcus jannaschii


<220>
<221>  MISC_FEATURE
<222>  (1)..(412)
<223>  Mja_PEP

<400>  516

Cys Ile Glu Gly Asp Ala Lys Ile Leu Thr Asp Arg Gly Phe Leu Lys 
1               5                   10                  15      


Met Lys Glu Val Tyr Lys Leu Val Lys Asn Gly Glu Lys Leu Lys Val 
            20                  25                  30          


Leu Gly Leu Asn Ala Glu Thr Leu Lys Thr Glu Trp Lys Glu Ile Ile 
        35                  40                  45              


Asp Ala Gln Lys Arg Glu Ala Arg Arg Tyr Glu Ile Gly Val Tyr Arg 
    50                  55                  60                  


Lys Asn Lys Asn Thr Lys Asp Thr Ile Lys Ile Thr Pro Asp His Lys 
65                  70                  75                  80  


Phe Pro Val Phe Val Asn Gly Glu Leu Ser Lys Val Gln Leu Cys Asp 
                85                  90                  95      


Ile Ile Asp Asn Asn Leu Ser Val Leu Ser Ile Asp Tyr Ile Pro Met 
            100                 105                 110         


Ile Glu Glu Lys Tyr Glu Ser Leu Ala Glu Val Met Tyr Leu Gly Gly 
        115                 120                 125             


Ala Val Leu Ser Asp Gly His Ile Val Arg Arg Asn Gly Lys Pro Ile 
    130                 135                 140                 


Arg Val Arg Phe Thr Gln Lys Asp Thr Glu Glu Lys Lys Asp Phe Ile 
145                 150                 155                 160 


Glu Lys Val Lys Gly Asp Val Lys Leu Ile Gly Gly Asn Phe Ile Glu 
                165                 170                 175     


Ile Ser Asn Arg Asn Asn Val Ile Glu Tyr Gln Thr Ser Arg Lys Ile 
            180                 185                 190         


Pro Ser Glu Ile Leu Gly Phe Ile Glu Val Asn Ile Asn Thr Ile Pro 
        195                 200                 205             


Leu Tyr Ala Thr Lys Asp Glu Ile Ala Asp Leu Ile Ala Gly Phe Val 
    210                 215                 220                 


Asp Gly Asp Gly Cys Leu Ser Gly Lys Arg Arg Val Glu Ile Tyr Gln 
225                 230                 235                 240 


Asn Ser Ser His Ile Lys Lys Ile Glu Gly Leu Ile Val Gly Leu Tyr 
                245                 250                 255     


Arg Leu Gly Ile Ile Pro Arg Leu Arg Tyr Lys Arg Ser Ser Thr Ala 
            260                 265                 270         


Thr Ile Tyr Phe Asn Asn Asn Leu Glu Thr Ile Leu Gln Arg Thr Arg 
        275                 280                 285             


Arg Ile Lys Leu Asp Lys Leu Lys Glu Phe Lys Lys Pro Val Glu Asp 
    290                 295                 300                 


Lys Lys Leu Ile Asp Ile Ser Gln Ile Leu Pro Glu Leu Lys Glu Phe 
305                 310                 315                 320 


Asp Tyr Lys Gly Tyr Leu Tyr Lys Thr Tyr Lys Glu Lys Leu Phe Ile 
                325                 330                 335     


Gly Ile Asn Lys Leu Glu Glu Tyr Leu Ser Lys Ile Asp Lys Asp Gly 
            340                 345                 350         


Ile Glu Arg Ile Lys Gln Lys Ile Lys Leu Leu Lys Glu Ser Asp Ile 
        355                 360                 365             


Tyr Ser Ile Arg Ile Lys Lys Val Gly Glu Asp Tyr Gly Glu Val Tyr 
    370                 375                 380                 


Asn Ile Thr Val Lys Ala Glu Asn Glu Phe Asn His Asn Tyr Val Val 
385                 390                 395                 400 


Trp Thr Lys His Tyr Thr Pro Ile Val Val Phe Asn 
                405                 410         


<210>  517
<211>  476
<212>  PRT
<213>  Methanococcus jannaschii


<220>
<221>  MISC_FEATURE
<222>  (1)..(476)
<223>  Mja_Pol-2

<400>  517

Ser Ile Leu Pro Asp Glu Tyr Leu Thr Ile Ile Glu Glu Asp Gly Ile 
1               5                   10                  15      


Lys Val Val Lys Ile Gly Glu Tyr Ile Asp Asp Leu Met Arg Lys His 
            20                  25                  30          


Lys Asp Lys Ile Lys Phe Ser Gly Ile Ser Glu Ile Leu Glu Thr Lys 
        35                  40                  45              


Asn Leu Lys Thr Phe Ser Phe Asp Lys Ile Thr Lys Lys Cys Glu Ile 
    50                  55                  60                  


Lys Lys Val Lys Ala Leu Ile Arg His Pro Tyr Phe Gly Lys Ala Tyr 
65                  70                  75                  80  


Lys Ile Lys Leu Arg Ser Gly Arg Thr Ile Lys Val Thr Arg Gly His 
                85                  90                  95      


Ser Leu Phe Lys Tyr Glu Asn Gly Lys Ile Val Glu Val Lys Gly Asp 
            100                 105                 110         


Asp Val Arg Phe Gly Asp Leu Ile Val Val Pro Lys Lys Leu Thr Cys 
        115                 120                 125             


Val Asp Lys Glu Val Val Ile Asn Ile Pro Lys Arg Leu Ile Asn Ala 
    130                 135                 140                 


Asp Glu Glu Glu Ile Lys Asp Leu Val Ile Thr Lys His Lys Asp Lys 
145                 150                 155                 160 


Ala Phe Phe Val Lys Leu Lys Lys Thr Leu Glu Asp Ile Glu Asn Asn 
                165                 170                 175     


Lys Leu Lys Val Ile Phe Asp Asp Cys Ile Leu Tyr Leu Lys Glu Leu 
            180                 185                 190         


Gly Leu Ile Asp Tyr Asn Ile Ile Lys Lys Ile Asn Lys Val Asp Ile 
        195                 200                 205             


Lys Ile Leu Asp Glu Glu Lys Phe Lys Ala Tyr Lys Lys Tyr Phe Asp 
    210                 215                 220                 


Thr Val Ile Glu His Gly Asn Phe Lys Lys Gly Arg Cys Asn Ile Gln 
225                 230                 235                 240 


Tyr Ile Lys Ile Lys Asp Tyr Ile Ala Asn Ile Pro Asp Lys Glu Phe 
                245                 250                 255     


Glu Asp Cys Glu Ile Gly Ala Tyr Ser Gly Lys Ile Asn Ala Leu Leu 
            260                 265                 270         


Lys Leu Asp Glu Lys Leu Ala Lys Phe Leu Gly Phe Phe Val Thr Arg 
        275                 280                 285             


Gly Arg Leu Lys Lys Gln Lys Leu Lys Gly Glu Thr Val Tyr Glu Ile 
    290                 295                 300                 


Ser Val Tyr Lys Ser Leu Pro Glu Tyr Gln Lys Glu Ile Ala Glu Thr 
305                 310                 315                 320 


Phe Lys Glu Val Phe Gly Ala Gly Ser Met Val Lys Asp Lys Val Thr 
                325                 330                 335     


Met Asp Asn Lys Ile Val Tyr Leu Val Leu Lys Tyr Ile Phe Lys Cys 
            340                 345                 350         


Gly Asp Lys Asp Lys Lys His Ile Pro Glu Glu Leu Phe Leu Ala Ser 
        355                 360                 365             


Glu Ser Val Ile Lys Ser Phe Leu Asp Gly Phe Leu Lys Ala Lys Lys 
    370                 375                 380                 


Asn Ser His Lys Gly Thr Ser Thr Phe Met Ala Lys Asp Glu Lys Tyr 
385                 390                 395                 400 


Leu Asn Gln Leu Met Ile Leu Phe Asn Leu Val Gly Ile Pro Thr Arg 
                405                 410                 415     


Phe Thr Pro Val Lys Asn Lys Gly Tyr Lys Leu Thr Leu Asn Pro Lys 
            420                 425                 430         


Tyr Gly Thr Val Lys Asp Leu Met Leu Asp Glu Val Lys Glu Ile Glu 
        435                 440                 445             


Ala Phe Glu Tyr Ser Gly Tyr Val Tyr Asp Leu Ser Val Glu Asp Asn 
    450                 455                 460                 


Glu Asn Phe Leu Val Asn Asn Ile Tyr Ala His Asn 
465                 470                 475     


<210>  518
<211>  543
<212>  PRT
<213>  Methanococcus jannaschii


<220>
<221>  MISC_FEATURE
<222>  (1)..(543)
<223>  Mja_RFC-3

<400>  518

Cys Leu Thr Gly Asp Ala Lys Ile Thr Leu Pro Asp Glu Arg Glu Ile 
1               5                   10                  15      


Lys Ile Glu Asp Phe Ile Lys Met Phe Glu Glu Arg Lys Leu Lys His 
            20                  25                  30          


Val Leu Asn Arg Asn Gly Glu Asp Leu Val Leu Ala Gly Val Lys Phe 
        35                  40                  45              


Asn Ser Lys Ile Val Asn His Lys Val Tyr Arg Leu Val Leu Glu Ser 
    50                  55                  60                  


Gly Arg Glu Ile Glu Ala Thr Gly Asp His Lys Phe Leu Thr Arg Asp 
65                  70                  75                  80  


Gly Trp Lys Glu Val Tyr Glu Leu Lys Glu Asp Asp Glu Val Leu Val 
                85                  90                  95      


Tyr Pro Ala Leu Glu Gly Val Gly Phe Glu Val Asp Glu Arg Arg Ile 
            100                 105                 110         


Ile Gly Leu Asn Glu Phe Tyr Glu Phe Leu Thr Asn Tyr Glu Ile Lys 
        115                 120                 125             


Leu Gly Tyr Lys Pro Leu Gly Lys Ala Lys Ser Tyr Lys Glu Leu Ile 
    130                 135                 140                 


Thr Arg Asp Lys Glu Lys Ile Leu Ser Arg Val Leu Glu Leu Ser Asp 
145                 150                 155                 160 


Lys Tyr Ser Lys Ser Glu Ile Arg Arg Lys Ile Glu Glu Glu Phe Gly 
                165                 170                 175     


Ile Lys Ile Ser Leu Thr Thr Ile Lys Asn Leu Ile Asn Gly Lys Ile 
            180                 185                 190         


Asp Gly Phe Ala Leu Lys Tyr Val Arg Lys Ile Lys Glu Leu Gly Trp 
        195                 200                 205             


Asp Glu Ile Thr Tyr Asp Asp Glu Lys Ala Gly Ile Phe Ala Arg Leu 
    210                 215                 220                 


Leu Gly Phe Ile Ile Gly Asp Gly His Leu Ser Lys Ser Lys Glu Gly 
225                 230                 235                 240 


Arg Ile Leu Ile Thr Ala Thr Ile Asn Glu Leu Glu Gly Ile Lys Lys 
                245                 250                 255     


Asp Leu Glu Lys Leu Gly Ile Lys Ala Ser Asn Ile Ile Glu Lys Asp 
            260                 265                 270         


Ile Glu His Lys Leu Asp Gly Arg Glu Ile Lys Gly Lys Thr Ser Phe 
        275                 280                 285             


Ile Tyr Ile Asn Asn Lys Ala Phe Tyr Leu Leu Leu Asn Phe Trp Gly 
    290                 295                 300                 


Val Glu Ile Gly Asn Lys Thr Ile Asn Gly Tyr Asn Ile Pro Lys Trp 
305                 310                 315                 320 


Ile Lys Tyr Gly Asn Lys Phe Val Lys Arg Glu Phe Leu Arg Gly Leu 
                325                 330                 335     


Phe Gly Ala Asp Gly Thr Lys Pro Tyr Ile Lys Lys Tyr Asn Ile Asn 
            340                 345                 350         


Gly Ile Lys Leu Gly Ile Arg Val Glu Asn Ile Ser Lys Asp Lys Thr 
        355                 360                 365             


Leu Glu Phe Phe Glu Glu Val Lys Lys Met Leu Glu Glu Phe Glu Val 
    370                 375                 380                 


Glu Ser Tyr Ile Lys Val Ser Lys Ile Asp Asn Lys Asn Leu Thr Glu 
385                 390                 395                 400 


Leu Ile Val Lys Ala Asn Asn Lys Asn Tyr Leu Lys Tyr Leu Ser Arg 
                405                 410                 415     


Ile Ser Tyr Ala Tyr Glu Lys Asp Asn Phe Ala Arg Leu Val Gly Glu 
            420                 425                 430         


Tyr Leu Arg Ile Lys Glu Ala Tyr Lys Asp Ile Ile Leu Lys Glu Ile 
        435                 440                 445             


Ala Glu Asn Ala Leu Lys Glu Ala Asp Gly Glu Lys Ser Leu Arg Glu 
    450                 455                 460                 


Leu Ala Arg Lys Tyr Asn Val Pro Val Asp Phe Ile Ile Asn Gln Leu 
465                 470                 475                 480 


Lys Gly Lys Asp Ile Gly Leu Pro Arg Asn Phe Met Thr Phe Glu Glu 
                485                 490                 495     


Phe Leu Lys Glu Lys Val Val Asp Gly Lys Tyr Val Ser Glu Arg Ile 
            500                 505                 510         


Ile Lys Lys Glu Cys Ile Gly Tyr Arg Asp Val Tyr Asp Ile Thr Cys 
        515                 520                 525             


His Lys Asp Pro Ser Phe Ile Ala Asn Gly Phe Val Ser His Asn 
    530                 535                 540             


<210>  519
<211>  494
<212>  PRT
<213>  Methanococcus jannaschii


<220>
<221>  MISC_FEATURE
<222>  (1)..(494)
<223>  Mja_r-Gyr

<400>  519

Cys Leu Thr Pro Asp Thr Tyr Val Val Leu Gly Asp Gly Arg Ile Glu 
1               5                   10                  15      


Thr Ile Glu Asp Ile Val Asn Ala Lys Glu Arg Asn Val Leu Ser Leu 
            20                  25                  30          


Asp Leu Asp Asn Leu Ser Ile Lys Ile Asp Thr Ala Ile Lys Phe Trp 
        35                  40                  45              


Lys Leu Arg Tyr Asn Gly Asn Leu Ser Lys Ile Thr Leu Ser Asn Asn 
    50                  55                  60                  


Tyr Glu Leu Lys Ala Thr Pro Asp His Cys Leu Leu Val Leu Arg Asp 
65                  70                  75                  80  


Asn Gln Leu Lys Trp Ile Pro Ala Lys Asp Ile Lys Glu Asn Asp Tyr 
                85                  90                  95      


Ile Ala Met Pro Phe Asn Tyr Lys Val Glu Arg Lys Pro Ile Ser Leu 
            100                 105                 110         


Leu Asn Leu Leu Lys Tyr Leu Asp Ile Thr Asp Val Leu Ile Glu Phe 
        115                 120                 125             


Asp Glu Asn Ser Thr Ile Phe Glu Lys Ile Ala Glu Tyr Ile Arg Asn 
    130                 135                 140                 


Asn Ile Lys Thr Ser Thr Lys Tyr Lys Tyr Leu Arg Asn Arg Arg Val 
145                 150                 155                 160 


Pro Leu Lys Tyr Leu Ile Glu Trp Asn Phe Asp Leu Asp Glu Ile Glu 
                165                 170                 175     


Lys Glu Ala Lys Tyr Ile Tyr Lys Ser Val Ala Gly Thr Lys Lys Ile 
            180                 185                 190         


Pro Leu Phe Lys Leu Asp Glu Arg Phe Trp Tyr Phe Ala Gly Leu Val 
        195                 200                 205             


Leu Gly Asp Gly Ser Ile Gln Asp Ser Lys Ile Arg Ile Ala Gln Thr 
    210                 215                 220                 


Pro Leu Lys Asp Val Lys Ser Ile Leu Asp Glu Thr Phe Pro Phe Leu 
225                 230                 235                 240 


His Asn Trp Ile Ser Gly Asn Gln Val Ile Ile Ser Asn Pro Ile Ile 
                245                 250                 255     


Ala Glu Ile Leu Glu Lys Leu Gly Met Arg Asn Gly Lys Leu Asn Gly 
            260                 265                 270         


Ile Ile Phe Ser Leu Pro Glu Ser Tyr Ile Asn Ala Leu Ile Ala Gly 
        275                 280                 285             


Tyr Phe Asp Thr Asp Gly Cys Phe Ser Leu Leu Tyr Asp Lys Lys Ala 
    290                 295                 300                 


Lys Lys His Asn Leu Arg Met Val Leu Thr Ser Lys Arg Arg Asp Val 
305                 310                 315                 320 


Leu Glu Lys Ile Gly Ile Tyr Leu Asn Ser Ile Gly Ile Leu Asn Thr 
                325                 330                 335     


Leu His Lys Ser Arg Glu Val Tyr Ser Leu Ile Ile Ser Asn Lys Ser 
            340                 345                 350         


Leu Glu Thr Phe Lys Glu Lys Ile Ala Lys Tyr Leu Lys Ile Arg Lys 
        355                 360                 365             


Glu Ala Phe Ile Asn Gly Tyr Lys Thr Tyr Lys Lys Glu His Glu Glu 
    370                 375                 380                 


Arg Phe Glu Cys Asp Leu Leu Pro Val Lys Glu Val Phe Lys Lys Leu 
385                 390                 395                 400 


Thr Phe Glu Lys Gly Arg Lys Glu Ile Leu Lys Asp Ser Lys Ile His 
                405                 410                 415     


Ile Glu Asn Trp Tyr Lys Glu Lys Thr Asn Asn Ile Pro Arg Glu Lys 
            420                 425                 430         


Leu Lys Thr Val Leu Arg Tyr Ala Asn Asn Ser Glu His Lys Glu Phe 
        435                 440                 445             


Leu Glu Lys Ile Val Asn Gly Asp Ile Ser Phe Val Arg Val Lys Lys 
    450                 455                 460                 


Val Glu Asn Ile Pro Tyr Asp Gly Tyr Val Tyr Asp Leu Ser Ile Lys 
465                 470                 475                 480 


His Asn Gln Asn Phe Ile Ser Asn Gly Val Ile Ser His Asn 
                485                 490                 


<210>  520
<211>  317
<212>  PRT
<213>  Mycobacterium phage KBG


<220>
<221>  MISC_FEATURE
<222>  (1)..(317)
<223>  MP-Be_gp51

<400>  520

Cys Ser Trp Thr Asn Ala Arg Ala Val Thr Arg Arg Gly Phe Val His 
1               5                   10                  15      


Val Asp Asp Leu Thr Thr Asp Asp Glu Val Met Ser Val Asp Asp Gln 
            20                  25                  30          


Gly Arg Thr Ile Trp Gln Gln Ile Asp Glu Val Val Arg Phe Pro Phe 
        35                  40                  45              


Ser Gly Thr Leu Tyr Ser Leu Gly Gly Arg Glu Ile Asn Ala Thr Ile 
    50                  55                  60                  


Thr Ala Asn His Arg Val Val Gly Leu Asn Arg Glu Lys Thr Lys Trp 
65                  70                  75                  80  


Val Glu His Thr Pro Thr Ser Leu Pro Gly Asn Lys Met Trp Val Tyr 
                85                  90                  95      


Thr Ala Gly Glu Gly Ser Asn Glu Asp Tyr Pro Leu Thr Asp Thr Glu 
            100                 105                 110         


Ile Arg Leu Ala Val Trp Gly Leu Thr Asp Ser His Arg Ser Pro Asp 
        115                 120                 125             


Gly Arg Trp Thr Phe Tyr Gln Ser Gly Glu Lys Ala Glu Gln Val Arg 
    130                 135                 140                 


Lys Leu Leu Ala Asp Ala Gly Ile Glu Tyr Arg Glu Arg Ala Arg Asn 
145                 150                 155                 160 


Arg Gly Ile Thr Glu Ile Asp Gly Lys Val Leu Lys Ala Pro Pro Lys 
                165                 170                 175     


Thr Gln Tyr Glu Phe Ser Leu Gly Lys Val Gln Glu Leu Asp Asp Leu 
            180                 185                 190         


Leu Asp Arg Gly Arg Ser Glu Leu Pro Thr Trp Thr Leu Ser Leu Ser 
        195                 200                 205             


Gln Arg Gln Ala Arg Leu Phe Leu Glu Glu Tyr Arg Phe Thr Asp Gly 
    210                 215                 220                 


Thr Asp Thr Thr Ser Ala Gly Asp Ser Tyr Val Leu Tyr Val Cys Lys 
225                 230                 235                 240 


Asp Arg Met Arg Glu Gln Leu Gln Met Leu Ala Ala Ala Asn Gly Leu 
                245                 250                 255     


Arg Ala Ser Thr Thr Glu Tyr Arg Pro Gly His Trp Arg Leu Asn Ile 
            260                 265                 270         


Ser Asn Arg Ala Leu Ser Gly Leu Tyr Lys Asn Thr Val Glu Glu Val 
        275                 280                 285             


Ala Tyr Glu Gly Glu Val Trp Cys Leu Arg Val Pro Asn Gly Arg Phe 
    290                 295                 300                 


Phe Ile Glu Asp Gly Gly Lys Ile His Leu Thr Gly Asn 
305                 310                 315         


<210>  521
<211>  407
<212>  PRT
<213>  Anabaena PCC7120


<220>
<221>  MISC_FEATURE
<222>  (1)..(407)
<223>  Nsp-PCC7120_RIR1

<400>  521

Cys Leu Pro Glu Asp Ala Leu Val His Thr Ala Lys Gly Leu Val Pro 
1               5                   10                  15      


Ile Arg Asp Val Gln Val Gly Asp Leu Val Gln Thr Pro Leu Gly Phe 
            20                  25                  30          


Arg Arg Val Val Asp Lys Phe Asp Gln Gly Phe Gln Asp Val Tyr Glu 
        35                  40                  45              


Ile Glu Thr Asn Ala Thr Tyr Pro Arg Ala Thr Leu Asn His Arg Gln 
    50                  55                  60                  


Ala Val Leu Glu Asp Ala Lys Gly Gly Ile Val Trp Lys His Ile Ala 
65                  70                  75                  80  


Ser Leu Glu Ala Gly Asp Arg Leu Leu His Asn Lys Gln Val Leu Pro 
                85                  90                  95      


Gly Thr Val Thr His Leu Pro Ala Asp Phe Thr Glu Ser Arg Pro Ser 
            100                 105                 110         


His Ser Arg Thr Ala Lys Ser Phe Val Val Pro Glu Leu Thr Ala Glu 
        115                 120                 125             


Val Ala Trp Leu Ile Gly Phe Thr His Gly Asp Gly Tyr Val Ala Leu 
    130                 135                 140                 


Gly Arg Asn Lys Tyr Asp Lys Pro Tyr Gly Arg Val Glu Trp Ser Met 
145                 150                 155                 160 


Asn Ser Leu Asp Ala Glu Val Thr Ser Arg Ile Gln Ala Lys Ile Asp 
                165                 170                 175     


Ala Ala Leu Ala Leu Phe Gly Leu Ser Ala Val His Ser Ile Thr Lys 
            180                 185                 190         


Gly Glu Asn Thr Ala Lys Ser Ile Cys Ser Ser Ile Arg Leu Ala Glu 
        195                 200                 205             


Tyr Phe His Arg His Ile Lys Gln Pro Asn Ile Pro Leu Thr Val Pro 
    210                 215                 220                 


Ser Phe Ile Leu Gln Gly Ser Val Asp Ile Arg Ala Ala Tyr Leu Ala 
225                 230                 235                 240 


Gly Leu Met Asp Ser Asp Gly Ala Val Asn Asn Arg Pro Pro His Leu 
                245                 250                 255     


Ile Thr Ser Val Tyr Arg Ser Phe Ile Arg Gln Val Ser Val Val Leu 
            260                 265                 270         


Ser Ser Leu Gly Ile Ala Gly Arg Leu Thr Thr Thr Tyr Pro Gln Asn 
        275                 280                 285             


Ser Asn Trp Gln Val Lys Tyr Asn Leu Thr Ile Pro Ala Leu Lys Glu 
    290                 295                 300                 


Arg Tyr Asn Ala Leu Ile Ser Pro His Ser Ala Lys Gly Glu Leu Arg 
305                 310                 315                 320 


Gln Gly Leu Lys Met Tyr Gly Phe Thr Val Pro Gly Ala Val Met Arg 
                325                 330                 335     


Glu Thr Tyr Thr Tyr Ser Glu Met Arg Glu Met Gly Phe Gln Gly Ser 
            340                 345                 350         


Arg Thr Val Asp Ala Asn Tyr Glu Arg Tyr Val Ala Glu Ala Asp Ile 
        355                 360                 365             


Ser Leu Asp Ile Pro Val Thr Val Lys Gly Leu Gly Ser Tyr Asp His 
    370                 375                 380                 


Val Gln Thr Tyr Asp Ile Glu Val Asp Glu Ala His Cys Phe Tyr Cys 
385                 390                 395                 400 


Asp Gly Tyr Leu Thr His Asn 
                405         


<210>  522
<211>  382
<212>  PRT
<213>  Pyrococcus abyssi


<220>
<221>  MISC_FEATURE
<222>  (1)..(382)
<223>  Pab_RIR1-3

<400>  522

Cys Val Val Gly Glu Thr Arg Ile Leu Thr Pro Glu Gly Tyr Ile Lys 
1               5                   10                  15      


Ala Glu Glu Leu Phe Lys Leu Ala Lys Glu Arg Gly Lys Met Glu Ala 
            20                  25                  30          


Ile Ala Val Glu Gly Ile Ala Glu Gly Gly Glu Pro Tyr Ala Tyr Ser 
        35                  40                  45              


Leu Glu Ile Leu Leu Pro Gly Asp Lys Gln Val Lys Tyr Glu Thr Val 
    50                  55                  60                  


His Gly Asn Ala Val Glu Val Ala Asp Pro Val Ser Val Pro Ala Tyr 
65                  70                  75                  80  


Val Trp Lys Val Gly Met Lys Glu Val Ala Arg Val Arg Thr Lys Glu 
                85                  90                  95      


Gly Tyr Glu Ile Thr Ala Thr Leu Asp His Lys Leu Met Thr Pro Glu 
            100                 105                 110         


Gly Trp Lys Glu Ile Lys Asp Leu Lys Pro Gly Asp Lys Ile Leu Leu 
        115                 120                 125             


Pro Arg Phe Glu Val Glu Glu Asp Phe Gly Ser Glu Ser Ile Gly Glu 
    130                 135                 140                 


Asp Leu Ala Phe Val Leu Gly Trp Phe Ile Gly Asp Gly Tyr Leu Asn 
145                 150                 155                 160 


Val Lys Asp Lys Arg Ala Trp Phe Tyr Phe Asn Ala Glu Lys Glu Glu 
                165                 170                 175     


Glu Ile Ala Trp Lys Ile Arg Glu Ile Leu Ala Lys Arg Phe Glu Ile 
            180                 185                 190         


Lys Ala Glu Pro His Arg Tyr Gly Asn Gln Ile Lys Leu Gly Val Arg 
        195                 200                 205             


Gly Lys Ala Tyr Glu Trp Leu Glu Ser Ile Val Lys Thr Asn Glu Lys 
    210                 215                 220                 


Arg Ile Pro Glu Ile Val Tyr Arg Leu Lys Pro Asn Glu Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Arg Gly Leu Phe Ser Ala Asp Gly Tyr Val Asp Asn Asp Met 
                245                 250                 255     


Ala Ile Arg Leu Thr Ser Lys Ser Arg Glu Leu Leu Arg Glu Val Gln 
            260                 265                 270         


Asp Leu Leu Leu Leu Phe Gly Ile Leu Ser Lys Ile Tyr Glu Arg Pro 
        275                 280                 285             


Tyr Lys Arg Glu Phe Lys Tyr Thr Thr Lys Asp Gly Glu Glu Arg Thr 
    290                 295                 300                 


Tyr Thr Thr Glu Gly Tyr Tyr Glu Leu Val Ile Ala Asn Tyr Ser Arg 
305                 310                 315                 320 


Lys Ile Phe Ala Glu Arg Ile Gly Leu Glu Gly Tyr Lys Met Glu Lys 
                325                 330                 335     


Leu Ser Leu Glu Lys Ile Lys Val Asp Glu Pro Ile Val Thr Val Glu 
            340                 345                 350         


Ser Val Glu Ile Leu Gly Lys Lys Leu Val Tyr Asp Phe Thr Val Pro 
        355                 360                 365             


Glu His His Met Tyr Ile Ser Asn Gly Phe Met Ser His Asn 
    370                 375                 380         


<210>  523
<211>  522
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  MISC_FEATURE
<222>  (1)..(522)
<223>  Pfu_KlbA

<400>  523

Ala Leu Tyr Asp Phe Ser Val Ile Gln Leu Ser Asn Gly Arg Phe Val 
1               5                   10                  15      


Leu Ile Gly Asp Leu Val Glu Glu Leu Phe Lys Lys Tyr Ala Glu Lys 
            20                  25                  30          


Ile Lys Thr Tyr Lys Asp Leu Glu Tyr Ile Glu Leu Asn Glu Glu Asp 
        35                  40                  45              


Arg Phe Glu Val Val Ser Val Ser Pro Asp Leu Lys Ala Asn Lys His 
    50                  55                  60                  


Val Val Ser Arg Val Trp Arg Arg Lys Val Arg Glu Gly Glu Lys Leu 
65                  70                  75                  80  


Ile Arg Ile Lys Thr Arg Thr Gly Asn Glu Ile Ile Leu Thr Arg Asn 
                85                  90                  95      


His Pro Leu Phe Ala Phe Ser Asn Gly Asp Val Val Arg Lys Glu Ala 
            100                 105                 110         


Glu Lys Leu Lys Val Gly Asp Arg Val Ala Val Met Met Arg Pro Pro 
        115                 120                 125             


Ser Pro Pro Gln Thr Lys Ala Val Val Asp Pro Ala Ile Tyr Val Lys 
    130                 135                 140                 


Ile Ser Asp Tyr Tyr Leu Val Pro Asn Gly Lys Gly Met Ile Lys Val 
145                 150                 155                 160 


Pro Asn Asp Gly Ile Pro Pro Glu Lys Ala Gln Tyr Leu Leu Ser Val 
                165                 170                 175     


Asn Ser Tyr Pro Val Lys Leu Val Arg Glu Val Asp Glu Lys Leu Ser 
            180                 185                 190         


Tyr Leu Ala Gly Val Ile Leu Gly Asp Gly Tyr Ile Ser Ser Asn Gly 
        195                 200                 205             


Tyr Tyr Ile Ser Ala Thr Phe Asp Asp Glu Ala Tyr Met Asp Ala Phe 
    210                 215                 220                 


Val Ser Val Val Ser Asp Phe Ile Pro Asn Tyr Val Pro Ser Ile Arg 
225                 230                 235                 240 


Lys Asn Gly Asp Tyr Thr Ile Val Thr Val Gly Ser Lys Ile Phe Ala 
                245                 250                 255     


Glu Met Leu Ser Arg Ile Phe Gly Ile Pro Arg Gly Arg Lys Ser Met 
            260                 265                 270         


Trp Asp Ile Pro Asp Val Val Leu Ser Asn Asp Asp Leu Met Arg Tyr 
        275                 280                 285             


Phe Ile Ala Gly Leu Phe Asp Ala Asp Gly Tyr Val Asp Glu Asn Gly 
    290                 295                 300                 


Pro Ser Ile Val Leu Val Thr Lys Ser Glu Thr Val Ala Arg Lys Ile 
305                 310                 315                 320 


Trp Tyr Val Leu Gln Arg Leu Gly Ile Ile Ser Thr Val Ser Arg Val 
                325                 330                 335     


Lys Ser Arg Gly Phe Lys Glu Gly Glu Leu Phe Arg Val Ile Ile Ser 
            340                 345                 350         


Gly Val Glu Asp Leu Ala Lys Phe Ala Lys Phe Ile Pro Leu Arg His 
        355                 360                 365             


Ser Arg Lys Arg Ala Lys Leu Met Glu Ile Leu Arg Thr Lys Lys Pro 
    370                 375                 380                 


Tyr Arg Gly Arg Arg Thr Tyr Arg Val Pro Ile Ser Ser Asp Met Ile 
385                 390                 395                 400 


Ala Pro Leu Arg Gln Met Leu Gly Leu Thr Val Ala Glu Leu Ser Lys 
                405                 410                 415     


Leu Ala Ser Tyr Tyr Ala Gly Glu Lys Val Ser Glu Ser Leu Ile Arg 
            420                 425                 430         


His Ile Glu Lys Gly Arg Val Lys Glu Ile Arg Arg Ser Thr Leu Lys 
        435                 440                 445             


Gly Ile Ala Leu Ala Leu Gln Gln Ile Ala Lys Asp Val Gly Asn Glu 
    450                 455                 460                 


Glu Ala Trp Val Arg Ala Lys Arg Leu Gln Leu Ile Ala Glu Gly Asp 
465                 470                 475                 480 


Val Tyr Trp Asp Glu Val Val Ser Val Glu Glu Val Asp Pro Lys Glu 
                485                 490                 495     


Leu Gly Ile Glu Tyr Val Tyr Asp Leu Thr Val Glu Asp Asp His Asn 
            500                 505                 510         


Tyr Val Ala Asn Gly Ile Leu Val Ser Asn 
        515                 520         


<210>  524
<211>  444
<212>  PRT
<213>  Pyrococcus horikoshii


<220>
<221>  MISC_FEATURE
<222>  (1)..(444)
<223>  Pho_IF2

<400>  524

Cys Leu Leu Pro Glu Glu Arg Val Ile Leu Pro Asp Tyr Gly Pro Ile 
1               5                   10                  15      


Thr Leu Glu Glu Leu Phe Asn Met Thr Lys Glu Thr Val Phe Lys Asp 
            20                  25                  30          


Glu Glu Lys Glu Val Arg Lys Leu Gly Ile Arg Met Pro Val Ala Gly 
        35                  40                  45              


Val Asp Gly Arg Val Arg Leu Leu Glu Gly Pro Tyr Val Trp Lys Val 
    50                  55                  60                  


Arg Tyr Lys Gly Lys Met Leu Arg Val Lys Leu Lys Asp Trp His Ser 
65                  70                  75                  80  


Val Ala Val Thr Pro Glu His Pro Phe Leu Thr Thr Arg Gly Trp Val 
                85                  90                  95      


Arg Ala Asp Gln Leu Lys Pro Gly Asp Tyr Val Ala Val Pro Lys Ile 
            100                 105                 110         


Leu Pro Gly Lys Asp Asp Lys Glu Lys Phe Leu Gln Tyr Val His Glu 
        115                 120                 125             


Lys Leu Lys Gly Lys Val His Ile Lys Leu Pro Ser Ser Asp Glu Glu 
    130                 135                 140                 


Trp Glu Thr Phe Phe Tyr Phe Ala Gly Thr Ile Phe Gly Arg Glu Asn 
145                 150                 155                 160 


Ser Val Asn Pro Glu Gly Leu Thr His Glu Val Lys Ala Leu Leu Glu 
                165                 170                 175     


Leu Phe Lys Val Leu Phe Glu Tyr Pro Arg Glu Val Leu Arg Val Leu 
            180                 185                 190         


Phe Met Ala Pro Val Arg Tyr Val Ala Asn Phe Leu Arg Gly Phe Phe 
        195                 200                 205             


Asp Ile Asn Gly Tyr Val Asn Gly Glu Glu Leu Arg Val Glu Val Arg 
    210                 215                 220                 


Gly Ala Pro His Glu Val Leu Glu Glu Leu Ser Leu Ile Leu Leu Arg 
225                 230                 235                 240 


Leu Gly Ile Val Ser Lys Ile Tyr Pro Thr Ser Leu Ala Ile Ser Gly 
                245                 250                 255     


Arg Arg Asn Leu Glu Leu Phe Arg Arg Tyr Ile Gly Phe Ser Glu Lys 
            260                 265                 270         


Gln Lys Ala Lys Glu Leu Glu Gly Ile Ile Arg Arg Ser Glu Asn Ser 
        275                 280                 285             


Glu Ser Tyr Pro Ile Phe Glu Glu Leu Arg Arg Ile Arg Leu Leu Phe 
    290                 295                 300                 


Gly Phe Thr Arg Ala Glu Leu Ser Ser Thr Ile Pro Leu Tyr Ser Lys 
305                 310                 315                 320 


Tyr Glu Ser Lys Glu Ala Pro Ser Tyr Glu Ile Leu Met Lys Ile Leu 
                325                 330                 335     


Asn Thr Ile Glu Lys Gly Ser Lys Asp Leu Asn Lys Lys Ile Thr Ile 
            340                 345                 350         


Leu Glu Gly Arg Val Arg Asp His Glu Tyr Ile Glu Glu Phe Lys Arg 
        355                 360                 365             


Glu Gly Leu Ile Lys Asp Gly Lys Leu Thr Glu Leu Gly Lys Glu Leu 
    370                 375                 380                 


Leu Glu Val Trp Arg Asn Arg Glu Phe Asp Ser Arg Asp Val Asn Tyr 
385                 390                 395                 400 


Leu Arg Asn Ile Ile Glu Asn Phe Val Phe Leu Pro Val Glu Lys Ile 
                405                 410                 415     


Glu Glu Phe Glu Tyr Asp Gly Tyr Val Tyr Asp Val Thr Thr Glu Thr 
            420                 425                 430         


His Asn Phe Ile Ala Asn Gly Ile Leu Val His Asn 
        435                 440                 


<210>  525
<211>  410
<212>  PRT
<213>  Pyrococcus horikoshii


<220>
<221>  MISC_FEATURE
<222>  (1)..(410)
<223>  Pho_r-Gyr

<400>  525

Cys Val Thr Pro Asp Thr Leu Val Ser Leu Ser Asp Gly Arg Ile Ile 
1               5                   10                  15      


Glu Ile Arg Glu Ala Val Glu Asn Ser Glu Glu Ser Leu Leu Gly Ile 
            20                  25                  30          


Asn Gly Leu Lys Pro Lys Glu Ala Lys Ala Leu Lys Phe Trp Glu Ile 
        35                  40                  45              


Asp Trp Asp Gly Pro Ile Lys Val Ile Lys Leu Lys Asn Gly His Glu 
    50                  55                  60                  


Ile Lys Ala Thr Pro Asp His Gly Leu Leu Val Met Arg Asp Gly Lys 
65                  70                  75                  80  


Ile Gly Trp Val Ser Ala Lys Asn Ile Arg Glu Gly Asp Tyr Val Ala 
                85                  90                  95      


Phe Ile Tyr Asn Leu Gly His Arg Gly Gly Lys Lys Tyr Thr Leu Pro 
            100                 105                 110         


Gln Leu Leu Lys Glu Leu Gly Ile Ser Glu Tyr Glu Asn Ser Ser Ser 
        115                 120                 125             


Gln Glu Leu Asn Asn Arg Glu Gln Glu Met Asp Ser Lys Gln Ile Ser 
    130                 135                 140                 


Ile Glu Leu Asp Glu Arg Phe Trp Tyr Ile Phe Gly Val Ile Leu Gly 
145                 150                 155                 160 


Lys Gly Thr Leu Lys Gly Asp Lys Val Val Ile Phe Gln Lys Asp Val 
                165                 170                 175     


Lys Pro Val Ile Glu Glu Ala Leu Pro Phe Val Arg Ile Phe Glu Ser 
            180                 185                 190         


Ala Asp His Ile Gly Phe Ser His Leu Ile Leu Ala Glu Val Phe Arg 
        195                 200                 205             


Arg Leu Gly Val Gly Glu Gly Lys Leu His Ser Leu Val Phe Gly Leu 
    210                 215                 220                 


Arg Glu Glu Tyr Ile Asn Ala Met Ile Ala Gly Tyr Phe Asp Ala Ser 
225                 230                 235                 240 


Gly Thr Phe Leu Arg Arg Ala Val Leu Thr Ser Lys Arg Gly Asp Ile 
                245                 250                 255     


Leu Arg Met Leu Ser Val Tyr Leu Tyr Gln Ile Gly Ile Val Asn Asn 
            260                 265                 270         


Leu Arg Arg Asp Glu His Ala Gly Val Trp Glu Leu Ile Ile Ser Asp 
        275                 280                 285             


Leu Glu Lys Phe Arg Glu Lys Ile Tyr Pro Tyr Leu Arg Ile Lys Lys 
    290                 295                 300                 


Ser Gln Phe Asp Lys Val Tyr Ser Ile Ser Lys Asn Glu Gly Asp Phe 
305                 310                 315                 320 


Leu Pro Val Ala Ser Ile Phe Arg Lys Leu Lys Phe Arg Asp Gly Phe 
                325                 330                 335     


Lys Asn Arg Ile Leu Asp Glu Glu Ile Pro Arg Asp Glu Val Ala Lys 
            340                 345                 350         


Val Leu Glu Tyr Ala Glu Asp Ser Pro Glu Lys Glu Phe Leu Asn Ser 
        355                 360                 365             


Leu Val Glu Ala Arg Val Thr Trp Val Arg Val Glu Lys Ile Glu Glu 
    370                 375                 380                 


Arg His Tyr Thr Gly Lys Leu Tyr Asp Phe Thr Thr Thr Thr Glu Asn 
385                 390                 395                 400 


Phe Ile Ser Asn Gly Ile Val Ser His Asn 
                405                 410 


<210>  526
<211>  456
<212>  PRT
<213>  Phaeosphaeria nodorum


<220>
<221>  MISC_FEATURE
<222>  (1)..(456)
<223>  Pno_RPA2

<400>  526

Cys Leu Ser Ala Asp His Glu Val Leu Thr Ser Thr Gly Trp Lys Ala 
1               5                   10                  15      


Leu Pro Ala Ile Lys Asp Ala Asp Gln Val Met Thr Leu Asp Leu Gln 
            20                  25                  30          


Thr Gly Thr Gln Gln Trp Asn Ser Val Gln Ala Thr Thr Arg Phe Ala 
        35                  40                  45              


Arg Glu Gly Ser Leu Tyr Arg Leu Lys Ser Asp Asp Met Asp Ala Val 
    50                  55                  60                  


Cys Asn Glu Ser His Arg Trp Tyr Leu Asn Thr Lys Asp Gln Pro Thr 
65                  70                  75                  80  


Thr Tyr Thr Ala Phe Thr Thr Gln Gln Met Leu Asp Asn Gln Leu Val 
                85                  90                  95      


Ala Leu Arg Asn Ser Ser Gly Lys Ala Thr Asp Gln Trp Asn His Glu 
            100                 105                 110         


Ser Gly Thr Thr Thr His Thr Asn His Asn Ile Pro Thr Val Gly His 
        115                 120                 125             


Asn Gly Asn Val Met Phe Ser Trp Pro Asp Cys Pro Trp Leu Pro Arg 
    130                 135                 140                 


Glu Phe Val Ala Asp Glu Ala Cys Asn Leu Asp Trp Cys Arg Phe Ile 
145                 150                 155                 160 


Gly Leu Val Met Gly Asp Gly Ser Ile Asp His Val Thr Asp Ala Gln 
                165                 170                 175     


Gly Gln Glu His Tyr Ser Ile Gln Ile His Gln Arg Ala Gly Asn Pro 
            180                 185                 190         


Ala Ser Asn Ala Asn Thr Glu Asp Val Leu Glu Arg Leu Ala Ala Lys 
        195                 200                 205             


Leu Pro Asn Phe Val Val His Pro Ser Cys Val Ser Gly Ala Glu Glu 
    210                 215                 220                 


Lys His Thr Trp Thr Ile Asn His Arg Asp Met Tyr His Phe Phe Leu 
225                 230                 235                 240 


Pro Met Met Arg Gly Pro Gln Ser Tyr Asp Pro Leu Asp Asn Ala Met 
                245                 250                 255     


Cys Arg Thr Tyr Gln Ala Pro Asp Tyr Gln Ala Leu Ser Arg Ser Asp 
            260                 265                 270         


Asn Glu Pro Ile Ile Pro Val Pro Ala Asp Trp Lys Thr Gly Asn Trp 
        275                 280                 285             


Trp His Leu Arg Arg Trp Ile Asn Tyr Pro Trp Leu Phe Ser Leu Ala 
    290                 295                 300                 


Gln Ser Gln Ala Arg Ala Met Ile Lys Gly Met Ala Ala Ala Asn Gly 
305                 310                 315                 320 


Asp Trp Ser Leu Ser Leu Lys Ala Arg Leu Asp Thr Gly Asp Ser Gly 
                325                 330                 335     


Val Val Arg Val Phe Ser Asn Ser Ile Pro Leu Met His Asp Met Ser 
            340                 345                 350         


Val Leu Gly Leu Leu Ala Asp Thr Arg Val Asn Ile Gly Val Asp His 
        355                 360                 365             


Lys Lys Gly Gln Met Gln Leu Gln Val Pro Val Thr Met Pro Ala Leu 
    370                 375                 380                 


Leu Ala Trp Cys Ile Ser Phe Ser Phe Ala Asn Ser Asp Leu Ala Val 
385                 390                 395                 400 


Ala Ala Pro Lys Pro Glu Ala Tyr Asp Asn Pro Arg His Asp Gly Phe 
                405                 410                 415     


Val Tyr Cys Leu Thr Val Pro Asn Gly Asn Phe Leu Ala Arg Arg Thr 
            420                 425                 430         


Val Glu Tyr Ser Asp Asn Asp Lys Ile Gln Glu Val Ile Asp Ala Ala 
        435                 440                 445             


Gln Lys Pro Phe Phe Thr Gly Asn 
    450                 455     


<210>  527
<211>  348
<212>  PRT
<213>  Salmonella phage SETP3


<220>
<221>  MISC_FEATURE
<222>  (1)..(348)
<223>  SaP-SETP3_Helicase

<400>  527

Cys Leu Lys Arg Gly Thr Glu Val Ile Met Phe Asp Gly Thr Thr Lys 
1               5                   10                  15      


Lys Val Glu Asp Val Ile Val Gly Asp Val Leu Met Gly Pro Asp Ser 
            20                  25                  30          


Thr Pro Arg Asn Val Leu Ser Leu Gly Arg Gly Arg Glu Met Met Tyr 
        35                  40                  45              


Glu Val Lys Pro Arg Lys Gly Glu Ser Tyr Thr Val Asn Glu Ser His 
    50                  55                  60                  


Ile Leu Ser Leu Arg Thr Thr Thr Gly Ile Ala Lys Gly Ser Trp Pro 
65                  70                  75                  80  


Asp Asn Thr Val Phe Asp Ile Ser Val Arg Asp Trp Leu Lys Leu Pro 
                85                  90                  95      


Lys Tyr Val Thr Gly Pro Asn Gly Tyr Leu Lys Gly Trp Arg Val Pro 
            100                 105                 110         


Val Asp Phe Pro Arg Lys Glu Gln Asp Glu Ala Leu Leu Pro Pro Tyr 
        115                 120                 125             


Leu Met Gly Leu Trp Leu Gly Asp Gly Thr Ser Ser Ser Gly Ala Ile 
    130                 135                 140                 


Thr Ser Gly Glu Asn Glu Lys Glu Ile Arg Ala Tyr Leu Glu Ser Tyr 
145                 150                 155                 160 


Ala Ala Arg Asn Gly Met Gln Ile Arg Lys Glu Gly Leu Thr Trp Ser 
                165                 170                 175     


Ile Ser His Gly Asn Thr Gly His Lys Lys His Gly Phe Thr His Ala 
            180                 185                 190         


Leu Lys Ser Ala Gly Val Leu Asn Asn Lys His Ile Pro His Asn Tyr 
        195                 200                 205             


Lys Cys Gly Asp Arg Arg Gln Arg Leu Glu Leu Leu Ala Gly Leu Leu 
    210                 215                 220                 


Asp Ser Asp Gly Tyr Cys Asp Leu Ser Lys Ala Gly Phe Asp Trp Ile 
225                 230                 235                 240 


Ser Val Ser Glu Arg Leu Ala Asp Asp Phe Cys Tyr Leu Cys Arg Ser 
                245                 250                 255     


Leu Gly Phe Ala Ala Tyr Lys Lys Lys Thr Cys Lys Arg Cys Ala Asn 
            260                 265                 270         


Thr Asp Val Trp Gly Asp Tyr Phe Arg Val Ser Val Ser Gly Asp Phe 
        275                 280                 285             


Ser Glu Val Pro Phe Val Arg Gly Arg His Gln Asn Leu Pro Lys Arg 
    290                 295                 300                 


Asn Ile Asn Lys Asn Val Leu Asn Val Gly Ile Glu Ser Ile Thr Pro 
305                 310                 315                 320 


Val Gly Val Asp Asp Tyr Phe Gly Phe Thr Ile Asp Gly Asp Ser Arg 
                325                 330                 335     


Phe Leu Leu Gly Asp Phe Thr Val Thr His Asn Thr 
            340                 345             


<210>  528
<211>  420
<212>  PRT
<213>  Staphylococcus phage Twort


<220>
<221>  MISC_FEATURE
<222>  (1)..(420)
<223>  StP-Twort_ORF6

<400>  528

Cys Ile Ser Met Asp Ser Met Ile Leu Thr Thr Glu Gly Tyr Lys Ser 
1               5                   10                  15      


Leu Gln Glu Ile Phe Glu Thr Gln Gly Val Lys Val Asp Asn Lys Glu 
            20                  25                  30          


Lys Val Ile Glu Leu Lys Tyr Pro Leu Ile Asn Arg Tyr Gly Asp Val 
        35                  40                  45              


Glu Tyr Thr Ser His Phe Thr Lys Asn Gly Glu Lys Pro Thr Lys Arg 
    50                  55                  60                  


Ile Lys Thr Asn Lys Gly Ile Glu Leu Val Asn Thr Tyr Asn His Pro 
65                  70                  75                  80  


Leu Leu Val Arg Glu Gly Phe Asn Leu Ile Trp Lys Lys Ser Glu Asp 
                85                  90                  95      


Ile Glu Val Gly Asp Ile Leu Val Ser Arg Val Gly Asp His Gln Phe 
            100                 105                 110         


Gly Asn Asn Asn Thr Val Glu Asn Glu Glu Glu Ala Tyr Ala Leu Gly 
        115                 120                 125             


Cys Met Val Ala Asp Ser Tyr Leu Gly Ser Tyr Ser Arg Leu Ser Phe 
    130                 135                 140                 


Ser Asn Asp Lys Lys Glu Ile Leu Asp Lys Val Ser Lys Phe Trp Asn 
145                 150                 155                 160 


Thr Phe Ser Asn Lys Glu Val Tyr Tyr Asp Thr Tyr Lys Glu Ser Lys 
                165                 170                 175     


Gly Ile Thr Ile His Leu His Asp Thr Asn Lys Thr Lys Glu Phe His 
            180                 185                 190         


Asp Lys Tyr Lys Ile Glu Tyr Gly Val Ala Lys Asp Lys Lys Ile Pro 
        195                 200                 205             


Lys Cys Ile Met Glu Ser Pro Glu Asn Ile Gln Leu Ala Phe Val Ser 
    210                 215                 220                 


Gly Tyr Leu Glu Cys Glu Ser Ser Ile Ser Glu Lys Asn Leu Glu Val 
225                 230                 235                 240 


Thr Ser Ala Ser Lys Asp Leu Leu Lys Asp Leu Gln Leu Ile Leu Ser 
                245                 250                 255     


Asn Ile Gly Ile Val Ser Thr Asn Lys Glu Lys Val Val Lys Lys Tyr 
            260                 265                 270         


Lys His Asn Lys Tyr Tyr Arg Leu Ile Val Asn Arg Lys Glu Leu Ile 
        275                 280                 285             


Lys Leu Leu Pro Leu Leu Arg Phe Glu Thr Gln Gln Arg Lys Asn Gln 
    290                 295                 300                 


Lys Glu Asn Phe Leu Ser Asn Asn Thr Lys Ile Lys Ser Ser Tyr Gly 
305                 310                 315                 320 


Asn Thr Ile Glu Gly Ser Arg Tyr Leu Leu Lys Lys Tyr Arg Asp Ser 
                325                 330                 335     


Leu Asn Ile Asp Lys Lys Glu Phe Ser Lys Tyr Leu Ser Arg Asp Thr 
            340                 345                 350         


Ile Thr Ile Asp Arg Leu Arg Glu Val Ile Ser Leu Tyr Pro Asp Gly 
        355                 360                 365             


Asp Lys Glu Ile Arg Glu Leu Phe Glu Asn Val Val Asn Asn Asn Ile 
    370                 375                 380                 


Tyr Tyr Gln Lys Val Glu Gln Val Leu Glu Gly Glu Ile Ile Pro Thr 
385                 390                 395                 400 


Phe Asp Val Cys Met Pro Lys Thr His Ser Phe Ile Ala Asn Thr Ile 
                405                 410                 415     


Val Asn His Asn 
            420 


<210>  529
<211>  428
<212>  PRT
<213>  Trichodesmium erythraeum


<220>
<221>  MISC_FEATURE
<222>  (1)..(428)
<223>  Ter_DnaE-2

<400>  529

Cys Leu Ser Gly Ser Thr Lys Val Ile Asp Ala Ala Thr Gly Asn Leu 
1               5                   10                  15      


Phe Ser Leu Lys Glu Ile Ala Ala Gln Pro Glu Tyr Trp Leu Ser Arg 
            20                  25                  30          


Lys Val Phe Ser Leu Asp Leu Lys Ser Gln Gln Val Val Gln Gln Pro 
        35                  40                  45              


Ile Thr Glu Ile His Pro Asn Gly Val Arg Asp Val Trp Gln Ile Thr 
    50                  55                  60                  


Thr Arg Thr Asn Arg Lys Val Cys Ala Thr Asp Asp His Leu Phe Tyr 
65                  70                  75                  80  


Thr Val Leu Gly Trp Lys Pro Leu Lys Asp Phe Ser Val Gly Asp Arg 
                85                  90                  95      


Leu Gly Leu Pro Asn Lys Ile Pro Ile Asn Tyr Arg Ser Gln Ile Ser 
            100                 105                 110         


Asp Ser Lys Val Lys Phe Thr Ala Tyr Leu Ile Gly Glu Gly Tyr Leu 
        115                 120                 125             


Tyr Thr Asn Ser Phe Ser Cys Ser Tyr Phe Cys Asn Ser Asp Gly Glu 
    130                 135                 140                 


Leu Ile Ala Asp Phe Tyr Gly Cys Ala Glu Glu Leu Phe Gly Ser Ser 
145                 150                 155                 160 


Ala Pro Ile Glu Lys Gln Leu His Leu Gly Asn Lys Ser Val Ile Tyr 
                165                 170                 175     


Val Arg Ile Gly Leu Ile Ser Gly Leu Lys Asn Trp Val Asp Ser Tyr 
            180                 185                 190         


Leu Gln Cys Ala Asn Ser Arg Val Gln Glu Ile Pro Asn Trp Ile Phe 
        195                 200                 205             


Ser Leu Ser Gln Ser Gln Leu Gln Leu Phe Leu Gly Ile Leu Trp Ser 
    210                 215                 220                 


Thr Ser Gly Ile Phe Asp Glu Thr Ile Gly Tyr Thr Tyr Tyr Ser Ser 
225                 230                 235                 240 


Asn Ser Glu Val Leu Val Arg Gln Val Gln His Leu Phe Leu Arg Leu 
                245                 250                 255     


Gly Ile Val Ser Leu Phe Asn Val Asn Lys Val Lys Gly Gln Gly Glu 
            260                 265                 270         


Leu Asp Val Ser Tyr Val Val Glu Val Arg Gly Arg Glu Asp Met Leu 
        275                 280                 285             


Lys Phe Tyr Lys Leu Ile Lys Pro Tyr Leu Ser Ser Tyr Lys Gln Gly 
    290                 295                 300                 


Leu Cys Glu Ser Cys Tyr Leu Val Ile Lys Tyr Gln Gln Ser Tyr Gln 
305                 310                 315                 320 


Phe Lys Tyr Phe Leu Thr Pro Asp Phe Phe Asp Leu Ile Val Lys Ala 
                325                 330                 335     


Lys Lys Ala Ser Ser Met Thr Arg Ala Leu Gly Val Cys Gly Gly Glu 
            340                 345                 350         


Ile Ser Ser Val Trp Asn Phe Gln Asn Thr Ser Asn Arg Ser Leu Ser 
        355                 360                 365             


Phe Asp Lys Phe Asn Asn Phe Ser Thr Val Leu Ala Asp Glu Glu Leu 
    370                 375                 380                 


Thr Ala Ile Ala Asn Ser Asp Val Phe Trp Asp Glu Ile Ile Ser Ile 
385                 390                 395                 400 


Glu Tyr Ile Gly Lys Glu Glu Val Phe Asp Leu Thr Ile Pro Glu Thr 
                405                 410                 415     


His Asn Phe Ile Ala Asn Asp Phe Ile Val His Asn 
            420                 425             


<210>  530
<211>  323
<212>  PRT
<213>  Trichodesmium erythraeum


<220>
<221>  MISC_FEATURE
<222>  (1)..(323)
<223>  Ter_RIR1-3

<400>  530

Cys Val Ser Gly Asp Thr Leu Leu Ile Thr Arg Asp Ser Ile His Lys 
1               5                   10                  15      


Ile Lys Asp Val Val Gly Gln Lys Ile Glu Ile Trp Asn Gly Lys Asn 
            20                  25                  30          


Trp Ser Gln Val Ile Pro Leu Lys Thr Gly Lys Asp Arg Lys Leu Tyr 
        35                  40                  45              


Arg Val Arg Phe Gly Asp Gly Ser Tyr Leu Asp Val Thr Glu Tyr His 
    50                  55                  60                  


Arg Phe Phe Val Lys Asp Arg Phe Gly Lys Lys Tyr Glu Glu Val Gln 
65                  70                  75                  80  


Thr Lys Asp Leu Leu Thr His Ser Lys Tyr Ala Leu Asp Val Glu Pro 
                85                  90                  95      


Phe Ile Ile Asp Tyr His Asp Gly Asp Ser Ile Asn Leu Ser Tyr Ala 
            100                 105                 110         


Tyr Thr Leu Gly Ala Ala Leu Gly Asn Gly Thr Ile Asp Gln Asn Ser 
        115                 120                 125             


Asn Gly Lys Ile Arg Val Tyr Ser His Lys Ala Glu Leu Ile Phe Ala 
    130                 135                 140                 


Gly Asn Lys Ser Leu Glu Arg Gln Tyr Asn Tyr Leu Pro Ser Phe Val 
145                 150                 155                 160 


Asp Val Ile Asp Leu Gly Phe Ser Gly Glu Leu Leu Arg Arg Leu Gln 
                165                 170                 175     


Thr Glu Pro Asp Ala Leu Asn Thr Ile Ala Ser Trp Asn Lys Ser Ala 
            180                 185                 190         


Ile Leu Ala Phe Ile Ala Gly Leu Ala Asp Thr Asp Gly Ser Glu Thr 
        195                 200                 205             


Lys Gly Asn Gly Ile Lys Ile Ser Val Ser Asp Tyr Glu Arg Ala Lys 
    210                 215                 220                 


Arg Leu Gln Leu Leu Leu Thr Lys Cys Gly Ile Arg Ala Ser Val Asn 
225                 230                 235                 240 


Leu Met Ala Ser Arg Gly Cys Thr Thr Asn Leu Gly Glu Arg Asn Gln 
                245                 250                 255     


Asp Leu Tyr Tyr Leu Gln Ile Thr Asp Cys Arg Glu Ile Pro Cys Gln 
            260                 265                 270         


Arg Leu Asp Thr Thr Lys Val Cys Glu Ala Lys Phe Gln Gly Lys Tyr 
        275                 280                 285             


Gln Thr Ile Gln Asn Val Glu Glu Leu Pro Gly Leu His Asp Thr Tyr 
    290                 295                 300                 


Cys Phe Glu Glu Pro Glu Phe His Lys Gly Val Phe Gly Asn Ala Leu 
305                 310                 315                 320 


Thr Gly Asn 
            


<210>  531
<211>  403
<212>  PRT
<213>  Thermococcus kodakaraensis KOD1


<220>
<221>  MISC_FEATURE
<222>  (1)..(403)
<223>  Tko_Helicase

<400>  531

Cys Met His Pro Asp Thr Tyr Val Val Thr Lys Ser Gly Ala Lys Lys 
1               5                   10                  15      


Val Ser Glu Leu Thr Glu Gly Asp Glu Val Leu Thr His Thr Gly Thr 
            20                  25                  30          


Phe Lys Lys Val Ile Gln Pro Leu Arg Arg Glu His Lys Gly Arg Leu 
        35                  40                  45              


Leu Val Ile Lys Ala Tyr Gly Thr Val Pro Val Lys Ile Thr Pro Glu 
    50                  55                  60                  


His Met Val Trp Val Val Lys Gln Ile Arg His Lys Ser His Tyr Ser 
65                  70                  75                  80  


Asp Gly Arg Gln Val Ile Trp Trp Glu Phe Glu Gly Pro Glu Trp Met 
                85                  90                  95      


Thr Ala Gln Glu Leu Lys Glu Arg Leu Glu Ser Glu Thr Asp Pro Lys 
            100                 105                 110         


Val Ser Tyr Met Leu Leu Gln Pro Ile Pro Glu Pro Ser Val Asp Ala 
        115                 120                 125             


Asp Lys Ile Pro Leu Arg Lys Glu Val Tyr Val Val Asn Gln His Gly 
    130                 135                 140                 


Lys Thr Asp Lys Leu His Pro Ser Val Lys Arg Thr Pro Glu Tyr Leu 
145                 150                 155                 160 


Pro Leu Asn Phe Glu Thr Ala Arg Leu Ile Gly Leu Trp Ile Ala Glu 
                165                 170                 175     


Gly Ser Thr Ser Lys Asn Gly Val Ile Lys Phe Asp Ile Ser Ser Asn 
            180                 185                 190         


Glu Glu Asp Leu Thr Glu Phe Ile Thr Gly Thr Ile Arg Lys Tyr Phe 
        195                 200                 205             


Pro His Ala Lys Ile Val Val Lys Asp His Glu Arg Asn Arg Arg Thr 
    210                 215                 220                 


Val Arg Phe Cys Asn Lys Arg Phe Ala Glu Trp Leu Arg Glu Asn Ile 
225                 230                 235                 240 


Gly His Gly Ala Asp Asn Lys Ser Ile Pro Pro Leu Leu Leu Leu Asn 
                245                 250                 255     


Lys Asn Arg Glu Val Arg Leu Gly Leu Leu Arg Gly Leu Ile Glu Gly 
            260                 265                 270         


Asp Gly Tyr Val Arg Arg Glu Ser Gln Arg Arg Ala Asn Tyr Ile Ser 
        275                 280                 285             


Tyr Ser Thr Val Ser Pro Ser Leu Ala Tyr Gln Leu Gln Leu Leu Val 
    290                 295                 300                 


Ala Ser Leu Gly Tyr Thr Ser Ser Ile His Arg Ser Ile Arg Thr Glu 
305                 310                 315                 320 


Gly Ile Gly Lys Thr Arg Lys Pro Ile Tyr Asp Val Lys Val Ser Gly 
                325                 330                 335     


Lys Ser Tyr Tyr Ser Leu Leu Glu Glu Leu Gly Phe Glu Val Pro Gln 
            340                 345                 350         


Arg Gly Asn Arg Thr Tyr Asn Val Asn Arg Thr Trp Lys Asn Tyr Leu 
        355                 360                 365             


Leu Leu Lys Val Arg Ser Ile Glu Glu Glu Glu Tyr Glu Gly Asp Val 
    370                 375                 380                 


Tyr Asn Leu Glu Val Glu Gly Asp Glu Ser Gly Ser Val Gly Phe Ile 
385                 390                 395                 400 


Val His Asn 
            


<210>  532
<211>  536
<212>  PRT
<213>  Thermococcus kodakaraensis KOD1


<220>
<221>  MISC_FEATURE
<222>  (1)..(536)
<223>  Tko_Pol-2_Pko_Pol-2

<400>  532

Ser Ile Leu Pro Glu Glu Trp Leu Pro Val Leu Glu Glu Gly Glu Val 
1               5                   10                  15      


His Phe Val Arg Ile Gly Glu Leu Ile Asp Arg Met Met Glu Glu Asn 
            20                  25                  30          


Ala Gly Lys Val Lys Arg Glu Gly Glu Thr Glu Val Leu Glu Val Ser 
        35                  40                  45              


Gly Leu Glu Val Pro Ser Phe Asn Arg Arg Thr Asn Lys Ala Glu Leu 
    50                  55                  60                  


Lys Arg Val Lys Ala Leu Ile Arg His Asp Tyr Ser Gly Lys Val Tyr 
65                  70                  75                  80  


Thr Ile Arg Leu Lys Ser Gly Arg Arg Ile Lys Ile Thr Ser Gly His 
                85                  90                  95      


Ser Leu Phe Ser Val Arg Asn Gly Glu Leu Val Glu Val Thr Gly Asp 
            100                 105                 110         


Glu Leu Lys Pro Gly Asp Leu Val Ala Val Pro Arg Arg Leu Glu Leu 
        115                 120                 125             


Pro Glu Arg Asn His Val Leu Asn Leu Val Glu Leu Leu Leu Gly Thr 
    130                 135                 140                 


Pro Glu Glu Glu Thr Leu Asp Ile Val Met Thr Ile Pro Val Lys Gly 
145                 150                 155                 160 


Lys Lys Asn Phe Phe Lys Gly Met Leu Arg Thr Leu Arg Trp Ile Phe 
                165                 170                 175     


Gly Glu Glu Lys Arg Pro Arg Thr Ala Arg Arg Tyr Leu Arg His Leu 
            180                 185                 190         


Glu Asp Leu Gly Tyr Val Arg Leu Lys Lys Ile Gly Tyr Glu Val Leu 
        195                 200                 205             


Asp Trp Asp Ser Leu Lys Asn Tyr Arg Arg Leu Tyr Glu Ala Leu Val 
    210                 215                 220                 


Glu Asn Val Arg Tyr Asn Gly Asn Lys Arg Glu Tyr Leu Val Glu Phe 
225                 230                 235                 240 


Asn Ser Ile Arg Asp Ala Val Gly Ile Met Pro Leu Lys Glu Leu Lys 
                245                 250                 255     


Glu Trp Lys Ile Gly Thr Leu Asn Gly Phe Arg Met Arg Lys Leu Ile 
            260                 265                 270         


Glu Val Asp Glu Ser Leu Ala Lys Leu Leu Gly Tyr Tyr Val Ser Glu 
        275                 280                 285             


Gly Tyr Ala Arg Lys Gln Arg Asn Pro Lys Asn Gly Trp Ser Tyr Ser 
    290                 295                 300                 


Val Lys Leu Tyr Asn Glu Asp Pro Glu Val Leu Asp Asp Met Glu Arg 
305                 310                 315                 320 


Leu Ala Ser Arg Phe Phe Gly Lys Val Arg Arg Gly Arg Asn Tyr Val 
                325                 330                 335     


Glu Ile Pro Lys Lys Ile Gly Tyr Leu Leu Phe Glu Asn Met Cys Gly 
            340                 345                 350         


Val Leu Ala Glu Asn Lys Arg Ile Pro Glu Phe Val Phe Thr Ser Pro 
        355                 360                 365             


Lys Gly Val Arg Leu Ala Phe Leu Glu Gly Tyr Ser Ser Ala Met Ala 
    370                 375                 380                 


Thr Ser Thr Glu Gln Glu Thr Gln Ala Leu Asn Glu Lys Arg Ala Leu 
385                 390                 395                 400 


Ala Asn Gln Leu Val Leu Leu Leu Asn Ser Val Gly Val Ser Ala Val 
                405                 410                 415     


Lys Leu Gly His Asp Ser Gly Val Tyr Arg Val Tyr Ile Asn Glu Glu 
            420                 425                 430         


Leu Pro Phe Val Lys Leu Asp Lys Lys Lys Asn Ala Tyr Tyr Ser His 
        435                 440                 445             


Val Ile Pro Lys Glu Val Leu Ser Glu Val Phe Gly Lys Val Phe Gln 
    450                 455                 460                 


Lys Asn Val Ser Pro Gln Thr Phe Arg Lys Met Val Glu Asp Gly Arg 
465                 470                 475                 480 


Leu Asp Pro Glu Lys Ala Gln Arg Leu Ser Trp Leu Ile Glu Gly Asp 
                485                 490                 495     


Val Val Leu Asp Arg Val Glu Ser Val Asp Val Glu Asp Tyr Asp Gly 
            500                 505                 510         


Tyr Val Tyr Asp Leu Ser Val Glu Asp Asn Glu Asn Phe Leu Val Gly 
        515                 520                 525             


Phe Gly Leu Val Tyr Ala His Asn 
    530                 535     


<210>  533
<211>  186
<212>  PRT
<213>  Thermoplasma volcanium


<220>
<221>  MISC_FEATURE
<222>  (1)..(186)
<223>  Tvo_VMA

<400>  533

Cys Val Ser Gly Glu Thr Pro Val Tyr Leu Ala Asp Gly Lys Thr Ile 
1               5                   10                  15      


Lys Ile Lys Asp Leu Tyr Ser Ser Glu Arg Lys Lys Glu Asp Asn Ile 
            20                  25                  30          


Val Glu Ala Gly Ser Gly Glu Glu Ile Ile His Leu Lys Asp Pro Ile 
        35                  40                  45              


Gln Ile Tyr Ser Tyr Val Asp Gly Thr Ile Val Arg Ser Arg Ser Arg 
    50                  55                  60                  


Leu Leu Tyr Lys Gly Lys Ser Ser Tyr Leu Val Arg Ile Glu Thr Ile 
65                  70                  75                  80  


Gly Gly Arg Ser Val Ser Val Thr Pro Val His Lys Leu Phe Val Leu 
                85                  90                  95      


Thr Glu Lys Gly Ile Glu Glu Val Met Ala Ser Asn Leu Lys Val Gly 
            100                 105                 110         


Asp Met Ile Ala Ala Val Ala Glu Ser Glu Ser Glu Ala Arg Asp Cys 
        115                 120                 125             


Gly Met Ser Glu Glu Cys Val Met Glu Ala Glu Val Tyr Thr Ser Leu 
    130                 135                 140                 


Glu Ala Thr Phe Asp Arg Val Lys Ser Ile Ala Tyr Glu Lys Gly Asp 
145                 150                 155                 160 


Phe Asp Val Tyr Asp Leu Ser Val Pro Glu Tyr Gly Arg Asn Phe Ile 
                165                 170                 175     


Gly Gly Glu Gly Leu Leu Val Leu His Asn 
            180                 185     


<210>  534
<211>  152
<212>  PRT
<213>  Synechococcus vulcanus


<220>
<221>  MISC_FEATURE
<222>  (1)..(152)
<223>  Tvu_DnaE-N_NC-terminal

<400>  534

Cys Leu Ser Gly Glu Thr Ala Val Met Thr Val Glu Tyr Gly Ala Ile 
1               5                   10                  15      


Pro Ile Arg Arg Leu Val Gln Glu Arg Leu Ile Cys Gln Val Tyr Ser 
            20                  25                  30          


Leu Asp Pro Gln Gly His Leu Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              


Phe Gln Gly Phe Arg Pro Val Tyr Ala Tyr Gln Leu Glu Asp Gly Ser 
    50                  55                  60                  


Thr Ile Cys Ala Thr Pro Asp His Arg Phe Met Thr Thr Ser Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Glu Gln Ile Phe Arg Glu Gly Leu Glu Leu Trp Gln 
                85                  90                  95      


Val Ala Ile Ala Pro Pro Gly Ala Leu Ala Gln Gly Leu Lys Pro Ala 
            100                 105                 110         


Val Gln Met Ser Cys Met Lys Ile Val Gly Arg Arg Leu Val Gly Trp 
        115                 120                 125             


Gln Ala Val Tyr Asp Ile Gly Leu Ala Gly Asp His Asn Phe Leu Leu 
    130                 135                 140                 


Ala Asn Gly Ala Ile Ala Ala Asn 
145                 150         


<210>  535
<211>  307
<212>  PRT
<213>  uncultured archaeon GZfos9C4


<220>
<221>  MISC_FEATURE
<222>  (1)..(307)
<223>  Unc-ERS_RIR1

<400>  535

Cys Val Thr Ala Asp Thr Trp Val Thr Thr Ala Glu Gly Pro Arg Gln 
1               5                   10                  15      


Val Glu Glu Leu Ile Gly Lys Lys Phe Thr Ala Ile Val Asn Gly Glu 
            20                  25                  30          


Glu Trp Glu Ser Ser Glu Glu Gly Phe Phe Glu Thr Asp Val Lys Pro 
        35                  40                  45              


Val Tyr Thr Leu Lys Thr Ala Glu Gly Phe Glu Leu Arg Leu Thr Ala 
    50                  55                  60                  


Asp His Pro Val Met Lys Val Glu Arg Met Thr Arg Tyr Lys Val Glu 
65                  70                  75                  80  


Thr Gln Trp Ser Asn Ala Gly Asp Leu Lys Pro Gly Asp Lys Ile Ile 
                85                  90                  95      


Ile Asn Asn His Arg Asp Phe Gly Asn Trp Ser Val Lys Gly Lys Tyr 
            100                 105                 110         


Thr Glu Gly Glu Gly Tyr Leu Ile Gly Leu Leu Leu Gly Asp Gly Thr 
        115                 120                 125             


Ile Lys Lys Leu Asn Pro Trp Met Lys Ala Ile Ser Lys Lys Met Glu 
    130                 135                 140                 


Lys Ala Ser Ala Asp Phe Cys Glu Gly Ile Leu Arg Gly Leu Phe Asp 
145                 150                 155                 160 


Ala Asp Gly Ser Val Gln Gly Asn Gln Ser Lys Gly Val Ser Ile Arg 
                165                 170                 175     


Leu Ala Gln Ser Asp Val Glu Ile Leu Lys Ala Val Gln Arg Ile Leu 
            180                 185                 190         


Leu Arg Phe Gly Ile Phe Ser Lys Val Tyr Met Asn Arg Arg Gly Glu 
        195                 200                 205             


Arg Lys Val Lys Met Pro Asp Gly Lys Gly Gly Val Lys Glu Tyr Ile 
    210                 215                 220                 


Thr Lys Pro Gln His Glu Leu Val Ile Ser Asn Asp Asn Ile Leu Tyr 
225                 230                 235                 240 


Phe Ala Glu Arg Val Gly Phe Ser Asp Ala Glu Lys Met Glu Lys Leu 
                245                 250                 255     


Glu Lys Ala Ile Trp Asn Tyr Lys Arg Lys Met Asn Arg Glu Arg Phe 
            260                 265                 270         


Val Ala Ser Val Glu Glu Val Val Pro Asp Gly Val Glu Lys Val Tyr 
        275                 280                 285             


Asp Val Lys Ile Pro Gly Ile Asn Ala Phe Asn Ala Asn Gly Phe Val 
    290                 295                 300                 


Val His Asn 
305         


<210>  536
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Unc-ERS_RIR1_var7

<400>  536

Cys Val Thr Ala Asp Thr Trp Val Thr Thr Ala Glu Gly Pro Arg Gln 
1               5                   10                  15      


Val Glu Glu Leu Ile Gly Lys Lys Phe Thr Ala Ile Val Asn Gly Glu 
            20                  25                  30          


Glu Trp Glu Ser Ser Glu Glu Gly Phe Phe Glu Thr Asp Val Lys Pro 
        35                  40                  45              


Val Tyr Thr Leu Lys Thr Ala Glu Gly Phe Glu Leu Arg Leu Thr Ala 
    50                  55                  60                  


Asp His Pro Val Met Lys Val Glu Arg Met Thr Arg Tyr Lys Val Glu 
65                  70                  75                  80  


Thr Gln Trp Ser Asn Ala Gly Asp Leu Lys Pro Gly Asp Lys Ile Ile 
                85                  90                  95      


Ile Asn Asn His Arg Asp Phe Gly Asn Trp Ser Val Lys Gly Lys Tyr 
            100                 105                 110         


Thr Glu Gly Glu Gly Tyr Leu Ile Gly Leu Leu Leu Gly Asp Gly Thr 
        115                 120                 125             


Ile Lys Lys Leu Asn Pro Trp Met Lys Ala Ile Ser Lys Lys Met Glu 
    130                 135                 140                 


Lys Ala Ser Ala Asp Phe Cys Glu Gly Ile Leu Arg Gly Leu Ser Asp 
145                 150                 155                 160 


Ala Asp Gly Ser Val Gln Gly Asn Gln Ser Lys Gly Val Ser Ile Arg 
                165                 170                 175     


Leu Ala Gln Ser Asp Val Glu Ile Leu Lys Ala Val Gln Arg Ile Leu 
            180                 185                 190         


Leu Arg Phe Gly Ile Phe Ser Lys Val Tyr Met Asn Arg Arg Gly Glu 
        195                 200                 205             


Arg Lys Val Lys Met Pro Asp Gly Lys Gly Gly Val Lys Glu Tyr Ile 
    210                 215                 220                 


Thr Lys Pro Gln His Glu Leu Val Ile Ser Asn Asp Asn Ile Leu Tyr 
225                 230                 235                 240 


Phe Ala Glu Arg Val Gly Phe Ser Asp Ala Glu Lys Met Glu Lys Leu 
                245                 250                 255     


Glu Lys Ala Ile Trp Asn Tyr Lys Arg Lys Met Asn Arg Glu Arg Phe 
            260                 265                 270         


Val Ala Ser Val Glu Glu Val Val Pro Asp Gly Val Glu Lys Val Tyr 
        275                 280                 285             


Asp Val Lys Ile Pro Gly Ile Asn Ala Phe Asn Ala Asn Gly Phe Val 
    290                 295                 300                 


Val His Asn 
305         


<210>  537
<211>  88
<212>  PRT
<213>  Marine metagenome


<220>
<221>  MISC_FEATURE
<222>  (1)..(88)
<223>  gp41-1-N

<400>  537

Cys Leu Asp Leu Lys Thr Gln Val Gln Thr Pro Gln Gly Met Lys Glu 
1               5                   10                  15      


Ile Ser Asn Ile Gln Val Gly Asp Leu Val Leu Ser Asn Thr Gly Tyr 
            20                  25                  30          


Asn Glu Val Leu Asn Val Phe Pro Lys Ser Lys Lys Lys Ser Tyr Lys 
        35                  40                  45              


Ile Thr Leu Glu Asp Gly Lys Glu Ile Ile Cys Ser Glu Glu His Leu 
    50                  55                  60                  


Phe Pro Thr Gln Thr Gly Glu Met Asn Ile Ser Gly Gly Leu Lys Glu 
65                  70                  75                  80  


Gly Met Cys Leu Tyr Val Lys Glu 
                85              


<210>  538
<211>  37
<212>  PRT
<213>  Marine metagenome


<220>
<221>  MISC_FEATURE
<222>  (1)..(37)
<223>  gp41-1-C

<400>  538

Met Met Leu Lys Lys Ile Leu Lys Ile Glu Glu Leu Asp Glu Arg Glu 
1               5                   10                  15      


Leu Ile Asp Ile Glu Val Ser Gly Asn His Leu Phe Tyr Ala Asn Asp 
            20                  25                  30          


Ile Leu Thr His Asn 
        35          


<210>  539
<211>  91
<212>  PRT
<213>  Marine metagenome


<220>
<221>  MISC_FEATURE
<222>  (1)..(91)
<223>  gp41-8-N

<400>  539

Cys Leu Ser Leu Asp Thr Met Val Val Thr Asn Gly Lys Ala Ile Glu 
1               5                   10                  15      


Ile Arg Asp Val Lys Val Gly Asp Trp Leu Glu Ser Glu Leu Gly Pro 
            20                  25                  30          


Val Gln Val Thr Glu Val Leu Pro Ile Ile Lys Gln Pro Val Phe Glu 
        35                  40                  45              


Ile Val Leu Lys Ser Lys Ser Gly Lys Lys Ile Arg Val Ser Ala Asn 
    50                  55                  60                  


His Lys Phe Pro Thr Lys Asp Gly Leu Lys Thr Ile Asn Ser Gly Leu 
65                  70                  75                  80  


Lys Val Gly Asp Phe Leu Arg Ser Arg Ala Lys 
                85                  90      


<210>  540
<211>  45
<212>  PRT
<213>  Marine metagenome


<220>
<221>  MISC_FEATURE
<222>  (1)..(45)
<223>  gp41-8-C

<400>  540

Met Cys Glu Ile Phe Glu Asn Glu Ile Asp Trp Asp Glu Ile Ala Ser 
1               5                   10                  15      


Ile Glu Tyr Val Gly Val Glu Glu Thr Ile Asp Ile Asn Val Thr Asn 
            20                  25                  30          


Asp Arg Leu Phe Phe Ala Asn Gly Ile Leu Thr His Asn 
        35                  40                  45  


<210>  541
<211>  101
<212>  PRT
<213>  Marine metagenome


<220>
<221>  MISC_FEATURE
<222>  (1)..(101)
<223>  IMPDH-1-N

<400>  541

Cys Phe Val Pro Gly Thr Leu Val Asn Thr Glu Asn Gly Leu Lys Lys 
1               5                   10                  15      


Ile Glu Glu Ile Lys Val Gly Asp Lys Val Phe Ser His Thr Gly Lys 
            20                  25                  30          


Leu Gln Glu Val Val Asp Thr Leu Ile Phe Asp Arg Asp Glu Glu Ile 
        35                  40                  45              


Ile Ser Ile Asn Gly Ile Asp Cys Thr Lys Asn His Glu Phe Tyr Val 
    50                  55                  60                  


Ile Asp Lys Glu Asn Ala Asn Arg Val Asn Glu Asp Asn Ile His Leu 
65                  70                  75                  80  


Phe Ala Arg Trp Val His Ala Glu Glu Leu Asp Met Lys Lys His Leu 
                85                  90                  95      


Leu Ile Glu Leu Glu 
            100     


<210>  542
<211>  40
<212>  PRT
<213>  Marine metagenome


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  IMPDH-1-C

<400>  542

Met Lys Phe Lys Leu Lys Glu Ile Thr Ser Ile Glu Thr Lys His Tyr 
1               5                   10                  15      


Lys Gly Lys Val His Asp Leu Thr Val Asn Gln Asp His Ser Tyr Asn 
            20                  25                  30          


Val Arg Gly Thr Val Val His Asn 
        35                  40  


<210>  543
<211>  105
<212>  PRT
<213>  Marine metagenome


<220>
<221>  MISC_FEATURE
<222>  (1)..(105)
<223>  NrdJ-1-N

<400>  543

Cys Leu Val Gly Ser Ser Glu Ile Ile Thr Arg Asn Tyr Gly Lys Thr 
1               5                   10                  15      


Thr Ile Lys Glu Val Val Glu Ile Phe Asp Asn Asp Lys Asn Ile Gln 
            20                  25                  30          


Val Leu Ala Phe Asn Thr His Thr Asp Asn Ile Glu Trp Ala Pro Ile 
        35                  40                  45              


Lys Ala Ala Gln Leu Thr Arg Pro Asn Ala Glu Leu Val Glu Leu Glu 
    50                  55                  60                  


Ile Asp Thr Leu His Gly Val Lys Thr Ile Arg Cys Thr Pro Asp His 
65                  70                  75                  80  


Pro Val Tyr Thr Lys Asn Arg Gly Tyr Val Arg Ala Asp Glu Leu Thr 
                85                  90                  95      


Asp Asp Asp Glu Leu Val Val Ala Ile 
            100                 105 


<210>  544
<211>  40
<212>  PRT
<213>  Marine metagenome


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  NrdJ-1-C

<400>  544

Met Glu Ala Lys Thr Tyr Ile Gly Lys Leu Lys Ser Arg Lys Ile Val 
1               5                   10                  15      


Ser Asn Glu Asp Thr Tyr Asp Ile Gln Thr Ser Thr His Asn Phe Phe 
            20                  25                  30          


Ala Asn Asp Ile Leu Val His Asn 
        35                  40  


<210>  545
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Cth_ATPase_BIL

<400>  545
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgcttc gtggcgggca ctatgatcct gacagtcgcg      360

gggctggtcg ctattgagaa tattaaggcg ggggacaagg tcatcgctac taacccggag      420

acattcgagg tggctgagaa gaccgtcctg gagacctacg tgcgcgagac cacggagctc      480

ctgcacctga cgatcaatgg cgacgtcatt aagacaactt tcgagcatct cttctacgcc      540

aaggatgtcg ggttcgttga ggcgaaggag ctgcaggtcg gcgacaagct cctggattcc      600

aaggggaacg tgctcgtggt cgaggacaag aagatcaaga ttaccgatga gcccgttaag      660

gtgtacaatt tccaggttga tgacttccac acataccacg ttgggtgcaa tggggttctc      720

gttcataatt ctggtgtaaa agttgctgtc ctcgatacag ggatatccac tcatccagat      780

ctaaatattc gtggtggcgc aagctttgta ccaggggaac cgtcgactca agatgggaat      840

gggcatggca cgcatgtggc cgggacgatc gctgctttaa acaattcgat tggcgttctt      900

ggcgtagcgc cgagcgctga gctatacgct gttaaagtcc taggggcgag cggttcaggt      960

tcggtcagct cgattgccca aggattggaa tgggcaggga acaatggcat gcacgttgct     1020

aatttgagtt taggaagccc ttcgccaagt gccacacttg agcaagctgt taatagcgcg     1080

acttctagag gcgttcttgt tgtagcggca tctgggaact caggtgcagg ctcaatcagc     1140

tatccggcgc gctatgcgaa cgcaatggca gtcggagcta ctgatcaaaa caacaaccgc     1200

gctagctttt cacagtatgg cgcaggcctt gacattgtcg cacccggggt aaacgtgcag     1260

agcacatacc caggttcaac atatgccagc ttaaacggta catcgatggc tactcctcat     1320

gttgcaggtg cggccgccct tgttaaacaa aagaacccat cttggtctaa tgtacaaatt     1380

cgaaatcatc taaagaatac ggcaactagt ttaggaagca cgaacttgta tggaagcgga     1440

cttgttaacg cagaagcggc aacgcgt                                         1467


<210>  546
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Hwa_rPol_App

<400>  546
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctatt gaggctgatg agtcaatcgt tattaggcgg      360

gacggggaga ctgagctgac ggagatcggg tcgttcgtgg acactattct ggccgcggac      420

aaccaggaga cccggatcac ggatggccac gagattgcgc tcgctccgaa tgggctggag      480

gttccctccc tcgacaccga tgagcagatc aggtggaagc acattgaggc ggtgagccgg      540

catgcttcgc cagacgagat cctcctgatt gagctggagt caggcaggtc catcagggct      600

accaaggctc actccttcgt cacgaggagg gacggcgatg ttctcccagt ggctggcgag      660

acactggtgg tcggggacgt cctccctact gttggcagct acgatcatgc gtcggggtct      720

atctcagtgc cgctgcagtc ccagagcgtc gctgctgacg gcgggaccgt tgagcccaac      780

acaaatatca ctgccaacgc ggagcgcgat tcggcctcta ttacctctgc gggcatcatt      840

gggtcggcta cgtgggagag gatctccagc attgagacag tggcgccgga gtacgagtat      900

gtgtacgatc tctctgtttc cgggctggag actttcacta cgggggaggg ggtcgttact      960

cataattctg gtgtaaaagt tgctgtcctc gatacaggga tatccactca tccagatcta     1020

aatattcgtg gtggcgcaag ctttgtacca ggggaaccgt cgactcaaga tgggaatggg     1080

catggcacgc atgtggccgg gacgatcgct gctttaaaca attcgattgg cgttcttggc     1140

gtagcgccga gcgctgagct atacgctgtt aaagtcctag gggcgagcgg ttcaggttcg     1200

gtcagctcga ttgcccaagg attggaatgg gcagggaaca atggcatgca cgttgctaat     1260

ttgagtttag gaagcccttc gccaagtgcc acacttgagc aagctgttaa tagcgcgact     1320

tctagaggcg ttcttgttgt agcggcatct gggaactcag gtgcaggctc aatcagctat     1380

ccggcgcgct atgcgaacgc aatggcagtc ggagctactg atcaaaacaa caaccgcgct     1440

agcttttcac agtatggcgc aggccttgac attgtcgcac ccggggtaaa cgtgcagagc     1500

acatacccag gttcaacata tgccagctta aacggtacat cgatggctac tcctcatgtt     1560

gcaggtgcgg ccgcccttgt taaacaaaag aacccatctt ggtctaatgt acaaattcga     1620

aatcatctaa agaatacggc aactagttta ggaagcacga acttgtatgg aagcggactt     1680

gttaacgcag aagcggcaac gcgt                                            1704


<210>  547
<211>  2346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Kra_DnaB

<400>  547
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgcctc actgcgggga caagggttct gcgggctgat      360

acgggggcgg agactactat gggggagctg ttcgcgctgc aggctaggga cgttccggtg      420

tggtcactcg acgagtccct gcgctacgtc cgcaggcacc tcactagggt tttcccaacc      480

ggggtgaagc cagtcttccg gctgaggact gctagcggca agactgtccg cgctaccgct      540

aaccatccat tcctcaccta cgatgggtgg aagcctctcg gcgagctgtc ggtggctgac      600

aggctggcgg ttccgaggca cgtgccagct ccagagaggg tggcttcatg gacggacgat      660

caggtcctcc tgctcggcca tctcatcggc gatgggtcct tcgtcaagag gcagccactc      720

cgctacgcta gcgttgacga ggctaacctg tcggctgtga cggaggctgc tgctaatgcc      780

ttctccattg tcgcggttcg ggacgagtac gctgctgcta ggtgcaccac gctcaggctg      840

ccagctcctt acaggctgac ccacggcagg aggaatccac tcgctgcttg gctggacgag      900

ctcggcctgt tcgggctcag gagctacgag aagttcgtcc cgcaggaggt tttccacctg      960

cccaagaggc agatcgctct cttcctgcgg catctctggg cgactgatgg ctctgtgacg     1020

ctgacaaggc agtcacgcgg cgggaggatc tactacgcct cgacatctct ccagctgatt     1080

caggacgtct ccaggctgct cctgcggttc ggcattagca cgagggtgcg gacaactacc     1140

ccaaaggggg accacaggcc tggctacaca ctcgatgttt ctggcgtgga cgatcagagg     1200

cggttcctgc aggagatcgg cgtccatggg gccaggggcg ctaccgctga caggctcctg     1260

gaggtcatca gggatgtctc cgcgaacacg aatgtcgaca cagttcccag gcaggtttgg     1320

gacgatgtgc gcaggctcct ggtggagaag gagatgacgc acagggagtt cgctgctgct     1380

atggggacat cgttcggcgg gtccagcctc tggaagcatg ctccatctcg cgagaggctc     1440

ggcagggtgg cccaggtcct ggactcggcc gagctcgatg ttctggcggt gaacgacgtc     1500

ctgtgggatg aggtggtcgc gatcgagcct gacggcgagg agcaggtcta cgatgctact     1560

gttctcgggg ggcacaactt cgtggcggat ggcattgctg ttcataattc tggtgtaaaa     1620

gttgctgtcc tcgatacagg gatatccact catccagatc taaatattcg tggtggcgca     1680

agctttgtac caggggaacc gtcgactcaa gatgggaatg ggcatggcac gcatgtggcc     1740

gggacgatcg ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag     1800

ctatacgctg ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa     1860

ggattggaat gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct     1920

tcgccaagtg ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt     1980

gtagcggcat ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac     2040

gcaatggcag tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc     2100

gcaggccttg acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca     2160

tatgccagct taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt     2220

gttaaacaaa agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg     2280

gcaactagtt taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca     2340

acgcgt                                                                2346


<210>  548
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_Klba

<400>  548
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggtgctctc gcctacgatg agcctatcta cctctcggat      360

ggcaacatta tcaatatcgg ggagttcgtg gataagttct tcaagaagta caagaacagc      420

atcaagaagg aggacaatgg cttcgggtgg atcgatattg gcaacgagaa tatctacatt      480

aagtccttca acaagctcag cctgatcatt gaggacaagc ggatcctccg cgtctggcgc      540

aagaagtact cggggaagct gatcaagatt accacgaaga accgcaggga gatcacactc      600

actcacgatc atccggttta catctctaag accggcgagg tgctggagat taatgccgag      660

atggtgaagg tcggggacta catctacatt cccaagaaca ataccatcaa cctcgatgag      720

gttattaagg tggagacggt cgactacaat ggccacatct acgatctgac tgtggaggat      780

aatcatactt acattgctgg caagaatgag ggcttcgctg tttccaactc tggtgtaaaa      840

gttgctgtcc tcgatacagg gatatccact catccagatc taaatattcg tggtggcgca      900

agctttgtac caggggaacc gtcgactcaa gatgggaatg ggcatggcac gcatgtggcc      960

gggacgatcg ctgctttaaa caattcgatt ggcgttcttg gcgtagcgcc gagcgctgag     1020

ctatacgctg ttaaagtcct aggggcgagc ggttcaggtt cggtcagctc gattgcccaa     1080

ggattggaat gggcagggaa caatggcatg cacgttgcta atttgagttt aggaagccct     1140

tcgccaagtg ccacacttga gcaagctgtt aatagcgcga cttctagagg cgttcttgtt     1200

gtagcggcat ctgggaactc aggtgcaggc tcaatcagct atccggcgcg ctatgcgaac     1260

gcaatggcag tcggagctac tgatcaaaac aacaaccgcg ctagcttttc acagtatggc     1320

gcaggccttg acattgtcgc acccggggta aacgtgcaga gcacataccc aggttcaaca     1380

tatgccagct taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt     1440

gttaaacaaa agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg     1500

gcaactagtt taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca     1560

acgcgt                                                                1566


<210>  549
<211>  2490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_Pol-2

<400>  549
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggtagcatt ctccctgacg agtacctgac tattattgag      360

gaggatggca ttaaggtcgt gaagatcggg gagtacattg atgatctcat gcgcaagcac      420

aaggacaaga tcaagttctc gggcatctct gagattctgg agacaaagaa cctcaagact      480

ttctccttcg ataagatcac gaagaagtgc gagattaaga aggtgaaggc gctgatcagg      540

cacccatact tcggcaaggc ttacaagatc aagctccggt ctggccgcac cattaaggtc      600

acgagggggc attcactgtt caagtacgag aacgggaaga tcgtcgaggt taagggcgac      660

gatgtgcggt tcggggacct gatcgtggtc ccaaagaagc tcacctgcgt cgataaggag      720

gttgtgatca acattcctaa gcggctgatc aatgctgacg aggaggagat caaggatctc      780

gtcattacca agcacaagga caaggccttc ttcgttaagc tcaagaagac gctggaggat      840

atcgagaaca ataagctcaa ggtcatcttc gacgattgca ttctctacct gaaggagctc      900

ggcctgatcg actacaacat cattaagaag attaataagg ttgacatcaa gattctggat      960

gaggagaagt tcaaggccta caagaagtac ttcgacaccg tcatcgagca tggcaacttc     1020

aagaaggggc gctgcaatat tcagtacatc aagattaagg actacatcgc gaacattccc     1080

gacaaggagt tcgaggattg cgagatcggc gcctactcgg ggaagattaa tgcgctcctg     1140

aagctcgacg agaagctggc taagttcctc ggcttcttcg tgacacgcgg gaggctgaag     1200

aagcagaagc tcaagggcga gactgtctac gagatctcag tttacaagtc cctcccggag     1260

taccagaagg agatcgctga gacattcaag gaggtcttcg gcgccgggtc catggttaag     1320

gacaaagtga ctatggataa caagatcgtg tacctcgtcc tgaagtacat tttcaagtgc     1380

ggcgacaagg ataagaagca catccccgag gagctcttcc tggcctccga gagcgtgatc     1440

aagagcttcc tggacggctt cctcaaggcc aagaagaaca gccataaggg gacctcgacg     1500

ttcatggcga aggatgagaa gtacctcaac cagctgatga tcctcttcaa tctggttggc     1560

attccgacaa ggttcactcc cgtgaagaac aagggctaca agctcaccct gaatccgaag     1620

tacgggacgg tgaaggacct catgctggat gaggtcaagg agatcgaggc gttcgagtac     1680

agcggctacg tctacgatct ctctgtggag gataatgaga acttcctcgt caacaacatc     1740

tacgctcata attctggtgt aaaagttgct gtcctcgata cagggatatc cactcatcca     1800

gatctaaata ttcgtggtgg cgcaagcttt gtaccagggg aaccgtcgac tcaagatggg     1860

aatgggcatg gcacgcatgt ggccgggacg atcgctgctt taaacaattc gattggcgtt     1920

cttggcgtag cgccgagcgc tgagctatac gctgttaaag tcctaggggc gagcggttca     1980

ggttcggtca gctcgattgc ccaaggattg gaatgggcag ggaacaatgg catgcacgtt     2040

gctaatttga gtttaggaag cccttcgcca agtgccacac ttgagcaagc tgttaatagc     2100

gcgacttcta gaggcgttct tgttgtagcg gcatctggga actcaggtgc aggctcaatc     2160

agctatccgg cgcgctatgc gaacgcaatg gcagtcggag ctactgatca aaacaacaac     2220

cgcgctagct tttcacagta tggcgcaggc cttgacattg tcgcacccgg ggtaaacgtg     2280

cagagcacat acccaggttc aacatatgcc agcttaaacg gtacatcgat ggctactcct     2340

catgttgcag gtgcggccgc ccttgttaaa caaaagaacc catcttggtc taatgtacaa     2400

attcgaaatc atctaaagaa tacggcaact agtttaggaa gcacgaactt gtatggaagc     2460

ggacttgtta acgcagaagc ggcaacgcgt                                      2490


<210>  550
<211>  2691
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_RFC-3

<400>  550
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgcctg acgggggacg ctaagattac tctgcctgac      360

gagcgggaga tcaagattga ggatttcatt aagatgttcg aggagcgcaa gctgaagcac      420

gtcctcaaca ggaatgggga ggacctggtg ctcgctggcg tcaagttcaa ctccaagatc      480

gttaatcaca aggtgtacag gctggtcctg gagagcggga gggagatcga ggctaccggc      540

gaccataagt tcctgacgag ggatggctgg aaggaggtgt acgagctcaa ggaggacgat      600

gaggttctgg tgtacccggc tctggagggc gttgggttcg aggtggacga gcgcaggatc      660

attggcctga acgagttcta cgagttcctc acaaattacg agatcaagct ggggtacaag      720

ccactcggca aggcgaagtc atacaaggag ctgattactc gcgacaagga gaagatcctc      780

tctagggtcc tggagctctc cgataagtac tccaagagcg agatccggcg caagattgag      840

gaggagttcg gcatcaagat ttctctgacc acgatcaaga acctcattaa tgggaagatc      900

gacggcttcg ccctgaagta tgtgcgcaag atcaaggagc tcggctggga tgagatcacc      960

tacgacgatg agaaggctgg gatcttcgcc aggctcctgg gcttcatcat tggcgacggg     1020

cacctgtcga agtctaagga gggccggatc ctgattacag ctactattaa cgagctggag     1080

gggatcaaga aggatctgga gaagctcggc atcaaggcct cgaacatcat tgagaaggac     1140

attgagcata agctcgatgg gagggagatc aagggcaaga cctctttcat ctacattaac     1200

aataaggcct tctacctcct gctcaacttc tggggggtcg agattggcaa taagacgatc     1260

aacgggtaca atattccaaa gtggatcaag tacggcaaca agttcgttaa gagggagttc     1320

ctgaggggcc tcttcggggc tgacggcaca aagccttaca tcaagaagta caacatcaat     1380

gggattaagc tgggcattcg ggtggagaac atctccaagg ataagactct ggagttcttc     1440

gaggaggtca agaagatgct ggaggagttc gaggtcgaga gctacattaa ggtttcgaag     1500

atcgacaaca agaatctgac cgagctcatc gtcaaggcca acaataagaa ctacctgaag     1560

tacctctcaa ggatctccta cgcgtacgag aaggacaatt tcgctaggct ggtgggcgag     1620

tacctccgga tcaaggaggc gtacaaggac atcattctga aggagatcgc cgagaacgcg     1680

ctcaaggagg ccgatggcga gaagagcctg agggagctcg ctaggaagta caacgtcccg     1740

gttgacttca tcattaatca gctgaagggg aaggatatcg gcctcccccg caacttcatg     1800

acgttcgagg agttcctcaa ggagaaggtg gtcgacggca agtatgtgtc cgagcggatc     1860

attaagaagg agtgcatcgg ctaccgcgat gtgtacgaca ttacttgcca caaggatcct     1920

tctttcattg ctaacggctt cgtctctcat aactctggtg taaaagttgc tgtcctcgat     1980

acagggatat ccactcatcc agatctaaat attcgtggtg gcgcaagctt tgtaccaggg     2040

gaaccgtcga ctcaagatgg gaatgggcat ggcacgcatg tggccgggac gatcgctgct     2100

ttaaacaatt cgattggcgt tcttggcgta gcgccgagcg ctgagctata cgctgttaaa     2160

gtcctagggg cgagcggttc aggttcggtc agctcgattg cccaaggatt ggaatgggca     2220

gggaacaatg gcatgcacgt tgctaatttg agtttaggaa gcccttcgcc aagtgccaca     2280

cttgagcaag ctgttaatag cgcgacttct agaggcgttc ttgttgtagc ggcatctggg     2340

aactcaggtg caggctcaat cagctatccg gcgcgctatg cgaacgcaat ggcagtcgga     2400

gctactgatc aaaacaacaa ccgcgctagc ttttcacagt atggcgcagg ccttgacatt     2460

gtcgcacccg gggtaaacgt gcagagcaca tacccaggtt caacatatgc cagcttaaac     2520

ggtacatcga tggctactcc tcatgttgca ggtgcggccg cccttgttaa acaaaagaac     2580

ccatcttggt ctaatgtaca aattcgaaat catctaaaga atacggcaac tagtttagga     2640

agcacgaact tgtatggaag cggacttgtt aacgcagaag cggcaacgcg t              2691


<210>  551
<211>  2544
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Mja_r-Gyr

<400>  551
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgcctg acaccggaca catacgtggt tctcggggac      360

gggcggattg agactattga ggacatcgtg aatgctaagg agcgcaacgt gctctccctg      420

gacctcgata acctcagcat caagattgac acggcgatca agttctggaa gctgcgctac      480

aacggcaatc tgagcaagat cacactctcg aacaattacg agctcaaggc tactccggac      540

cactgcctcc tggtgctgag ggataaccag ctcaagtgga tccccgccaa ggacattaag      600

gagaacgatt acatcgcgat gccgttcaat tacaaggtcg agcggaagcc catctccctc      660

ctgaacctcc tgaagtacct ggacatcaca gatgttctca ttgagttcga cgagaactcc      720

actatcttcg agaagattgc cgagtacatc cgcaacaata ttaagacctc aacgaagtac      780

aagtacctca ggaaccgcag ggtcccgctg aagtacctca tcgagtggaa tttcgacctg      840

gatgagattg agaaggaggc taagtacatc tacaagtccg ttgccgggac caagaagatc      900

cccctgttca agctcgacga gaggttctgg tacttcgctg gcctggtcct cggcgacggg      960

tcgatccagg attctaagat ccggattgcc cagaccccac tgaaggacgt gaagagcatt     1020

ctcgatgaga cgttcccttt cctgcacaac tggatctcgg gcaatcaggt catcatttct     1080

aacccaatca ttgccgagat cctggagaag ctcggcatga ggaacgggaa gctcaatggc     1140

atcattttct cactgcctga gtcctacatc aacgccctca ttgcggggta cttcgacacc     1200

gatggctgct tctcgctcct gtacgacaag aaggcgaaga agcacaacct gcgcatggtc     1260

ctcacgtcaa agcggcgcga tgttctggag aagatcggga tctacctcaa ctccatcggc     1320

attctgaata cactccataa gtctagggag gtgtactcac tcatcatttc caacaagagc     1380

ctggagactt tcaaggagaa gatcgcgaag tacctgaaga ttcggaagga ggctttcatc     1440

aacggctaca agacatacaa gaaggagcat gaggagcgct tcgagtgcga cctcctgcca     1500

gttaaggagg tgttcaagaa gctcaccttc gagaagggcc ggaaggagat cctgaaggac     1560

tccaagatcc acattgagaa ctggtacaag gagaagacca acaatatccc gagggagaag     1620

ctgaagacgg ttctccggta cgcgaacaat agcgagcata aggagttcct ggagaagatc     1680

gtgaacgggg acatttcgtt cgtgcgcgtc aagaaggtgg agaatatccc gtacgatggc     1740

tacgtctacg atctctctat caagcataat cagaacttca tctctaatgg ggtcatttca     1800

cacaactctg gtgtaaaagt tgctgtcctc gatacaggga tatccactca tccagatcta     1860

aatattcgtg gtggcgcaag ctttgtacca ggggaaccgt cgactcaaga tgggaatggg     1920

catggcacgc atgtggccgg gacgatcgct gctttaaaca attcgattgg cgttcttggc     1980

gtagcgccga gcgctgagct atacgctgtt aaagtcctag gggcgagcgg ttcaggttcg     2040

gtcagctcga ttgcccaagg attggaatgg gcagggaaca atggcatgca cgttgctaat     2100

ttgagtttag gaagcccttc gccaagtgcc acacttgagc aagctgttaa tagcgcgact     2160

tctagaggcg ttcttgttgt agcggcatct gggaactcag gtgcaggctc aatcagctat     2220

ccggcgcgct atgcgaacgc aatggcagtc ggagctactg atcaaaacaa caaccgcgct     2280

agcttttcac agtatggcgc aggccttgac attgtcgcac ccggggtaaa cgtgcagagc     2340

acatacccag gttcaacata tgccagctta aacggtacat cgatggctac tcctcatgtt     2400

gcaggtgcgg ccgcccttgt taaacaaaag aacccatctt ggtctaatgt acaaattcga     2460

aatcatctaa agaatacggc aactagttta ggaagcacga acttgtatgg aagcggactt     2520

gttaacgcag aagcggcaac gcgt                                            2544


<210>  552
<211>  2271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tko_Helicase

<400>  552
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgcatg catcctgaca catacgtggt tactaagtcg      360

ggggctaaga aggtctctga gctgactgag ggggatgagg tcctgacaca taccggcacg      420

ttcaagaagg tcatccagcc actgaggagg gagcacaagg ggcgcctcct ggttatcaag      480

gcctacggca ccgtgcctgt caagattacg ccggagcaca tggtttgggt ggtcaagcag      540

atcaggcaca agtcccatta cagcgatggg cggcaggtca tttggtggga gttcgagggc      600

ccagagtgga tgacggctca ggagctgaag gagcgcctgg agtccgagac agacccaaag      660

gtgagctaca tgctcctgca gccaatccct gagccgtccg tggacgcgga taagattcct      720

ctgaggaagg aggtctacgt tgtgaaccag cacggcaaga cagacaagct ccatccgtcc      780

gtgaagcgga ctcccgagta cctgccactc aacttcgaga ccgctaggct gatcggcctc      840

tggattgctg aggggtcaac ttccaagaac ggcgtcatca agttcgacat ttccagcaat      900

gaggaggatc tgacggagtt catcacaggc actattagga agtacttccc gcacgctaag      960

atcgtcgtta aggaccatga gaggaacagg aggacggtcc ggttctgcaa taagcgcttc     1020

gcggagtggc tcagggagaa catcggccac ggggctgata ataagagcat tccgcccctc     1080

ctgctcctga acaagaatag ggaggtgcgc ctgggcctcc tgagggggct catcgagggc     1140

gacggctacg tgcgcaggga gtcgcagcgc agggcgaact acatcagcta ctcgacagtt     1200

tctccctcac tggcttacca gctccagctc ctggtggctt cgctgggcta cacctcgtct     1260

atccacaggt ctattcggac agagggcatc gggaagacta ggaagcccat ctacgatgtt     1320

aaggtgtcgg gcaagtctta ctactcactc ctggaggagc tcgggttcga ggtcccacag     1380

aggggcaaca ggacctacaa cgttaatcgc acgtggaaga attacctcct gctcaaggtg     1440

aggtccatcg aggaggagga gtacgagggc gacgtttaca atctggaggt tgagggggat     1500

gagtcaggct ctgtgggctt catcgtgcat aattctggtg taaaagttgc tgtcctcgat     1560

acagggatat ccactcatcc agatctaaat attcgtggtg gcgcaagctt tgtaccaggg     1620

gaaccgtcga ctcaagatgg gaatgggcat ggcacgcatg tggccgggac gatcgctgct     1680

ttaaacaatt cgattggcgt tcttggcgta gcgccgagcg ctgagctata cgctgttaaa     1740

gtcctagggg cgagcggttc aggttcggtc agctcgattg cccaaggatt ggaatgggca     1800

gggaacaatg gcatgcacgt tgctaatttg agtttaggaa gcccttcgcc aagtgccaca     1860

cttgagcaag ctgttaatag cgcgacttct agaggcgttc ttgttgtagc ggcatctggg     1920

aactcaggtg caggctcaat cagctatccg gcgcgctatg cgaacgcaat ggcagtcgga     1980

gctactgatc aaaacaacaa ccgcgctagc ttttcacagt atggcgcagg ccttgacatt     2040

gtcgcacccg gggtaaacgt gcagagcaca tacccaggtt caacatatgc cagcttaaac     2100

ggtacatcga tggctactcc tcatgttgca ggtgcggccg cccttgttaa acaaaagaac     2160

ccatcttggt ctaatgtaca aattcgaaat catctaaaga atacggcaac tagtttagga     2220

agcacgaact tgtatggaag cggacttgtt aacgcagaag cggcaacgcg t              2271


<210>  553
<211>  2670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Tko_Pol-2_Pko_Pol-2

<400>  553
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctatt ctgcctgagg agtggctgcc tgttctggag      360

gagggggagg ttcatttcgt taggatcggg gagctgattg accgcatgat ggaggagaac      420

gctggcaagg tcaagaggga gggggagacc gaggtcctgg aggtttcagg cctggaggtg      480

ccgtccttca accgcaggac gaataaggcg gagctgaaga gggtcaaggc tctcatccgg      540

cacgactact ctggcaaggt gtacaccatt aggctgaagt caggccggcg catcaagatt      600

acgtcagggc attccctgtt cagcgtccgg aacggcgagc tcgttgaggt gaccggcgac      660

gagctgaagc caggggatct cgtcgctgtt ccaaggaggc tggagctgcc agagaggaac      720

cacgtcctca atctggttga gctcctgctc ggcacaccgg aggaggagac tctggacatc      780

gtgatgacga ttcccgtcaa gggcaagaag aacttcttca aggggatgct caggacactg      840

cggtggatct tcggcgagga gaagaggcca aggactgctc gcaggtacct caggcatctg      900

gaggacctcg gctacgtgcg gctcaagaag atcgggtacg aggtcctgga ctgggatagc      960

ctcaagaatt accggcgcct gtacgaggct ctcgtggaga acgtccgcta caacggcaat     1020

aagagggagt acctggttga gttcaattcg atccgcgacg ccgtggggat tatgccgctg     1080

aaggagctca aggagtggaa gatcggcaca ctcaacgggt tccggatgcg caagctgatt     1140

gaggtcgatg agtccctcgc caagctgctc ggctactacg tgagcgaggg gtacgcgcgc     1200

aagcagagga acccgaagaa tggctggtcg tactctgtca agctgtacaa tgaggacccc     1260

gaggttctgg acgatatgga gcggctcgcg agccgcttct tcggcaaggt taggcggggg     1320

aggaactacg tggagatccc caagaagatt ggctacctgc tcttcgagaa tatgtgcggg     1380

gtgctcgctg agaacaagcg catcccagag ttcgtcttca catcacctaa gggcgttagg     1440

ctggccttcc tggaggggta ctccagcgct atggctacct ccacggagca ggagactcag     1500

gcgctgaacg agaagcgcgc tctggccaat cagctcgttc tgctcctgaa ctcggtgggc     1560

gtctctgctg tgaagctcgg ccacgactcc ggggtttaca gggtgtacat caatgaggag     1620

ctgccattcg tcaagctcga taagaagaag aacgcttact acagccatgt gattcctaag     1680

gaggtcctct cggaggtctt cggcaaggtt ttccagaaga acgtgtcccc acagaccttc     1740

cggaagatgg tcgaggacgg caggctggat cctgagaagg ctcagaggct gtcgtggctc     1800

atcgaggggg acgtggtcct cgatcgcgtc gagtctgttg acgtggagga ctacgatggc     1860

tacgtgtacg atctctctgt ggaggataat gagaacttcc tcgtgggctt cgggctcgtt     1920

tacgctcata attctggtgt aaaagttgct gtcctcgata cagggatatc cactcatcca     1980

gatctaaata ttcgtggtgg cgcaagcttt gtaccagggg aaccgtcgac tcaagatggg     2040

aatgggcatg gcacgcatgt ggccgggacg atcgctgctt taaacaattc gattggcgtt     2100

cttggcgtag cgccgagcgc tgagctatac gctgttaaag tcctaggggc gagcggttca     2160

ggttcggtca gctcgattgc ccaaggattg gaatgggcag ggaacaatgg catgcacgtt     2220

gctaatttga gtttaggaag cccttcgcca agtgccacac ttgagcaagc tgttaatagc     2280

gcgacttcta gaggcgttct tgttgtagcg gcatctggga actcaggtgc aggctcaatc     2340

agctatccgg cgcgctatgc gaacgcaatg gcagtcggag ctactgatca aaacaacaac     2400

cgcgctagct tttcacagta tggcgcaggc cttgacattg tcgcacccgg ggtaaacgtg     2460

cagagcacat acccaggttc aacatatgcc agcttaaacg gtacatcgat ggctactcct     2520

catgttgcag gtgcggccgc ccttgttaaa caaaagaacc catcttggtc taatgtacaa     2580

attcgaaatc atctaaagaa tacggcaact agtttaggaa gcacgaactt gtatggaagc     2640

ggacttgtta acgcagaagc ggcaacgcgt                                      2670


<210>  554
<211>  1620
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S135:Tvo_VMA

<400>  554
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgcgtt tcgggggaga cgccagtcta cctcgctgac      360

ggcaagacaa ttaagatcaa ggacctctac tcatctgagc gcaagaagga ggacaacatc      420

gtcgaggctg gctccgggga ggagatcatt cacctcaagg acccgatcca gatctacagc      480

tacgttgatg gcacgatcgt gcgctcccgc tcccgcctcc tgtacaaggg gaagtccagc      540

tacctggtgc gcatcgagac aattggcggg cgctcagtgt ccgtcactcc cgtccataag      600

ctcttcgttc tgaccgagaa gggcatcgag gaggttatgg cctcgaatct caaagtgggg      660

gacatgattg ctgctgtcgc tgagagcgag tcggaggccc gggattgcgg catgagcgag      720

gagtgcgtga tggaggcgga ggtctacacc tctctggagg ctacgttcga ccgcgttaag      780

tcaatcgcgt acgagaaggg cgacttcgat gtgtacgatc tgtcagttcc agagtacggc      840

aggaacttca ttggggggga ggggctgctc gtgctccaca actctggtgt aaaagttgct      900

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      960

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg     1020

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac     1080

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg     1140

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca     1200

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg     1260

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg     1320

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc     1380

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggttc aacatatgcc     1440

agcttaaacg gtacatcgat ggctactcct catgttgcag gtgcggccgc ccttgttaaa     1500

caaaagaacc catcttggtc taatgtacaa attcgaaatc atctaaagaa tacggcaact     1560

agtttaggaa gcacgaactt gtatggaagc ggacttgtta acgcagaagc ggcaacgcgt     1620


<210>  555
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S135:Tvu_DnaE-n_NC-terminal

<400>  555
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgcctc tcaggggaga ctgcggttat gacggtggag      360

tacggggcta ttcctattcg gcggctggtt caggagcggc tgatctgcca ggtttactcg      420

ctcgacccac agggccacct gtacacgcag cctatcgctc agtggcattt ccagggcttc      480

cgcccggtgt acgcgtacca gctggaggac gggtccacaa tttgcgctac tccggatcac      540

cggttcatga ccacgagcgg ccagatgctg cccatcgagc agattttccg cgaggggctg      600

gagctgtggc aggtggccat cgctccacca ggcgctctcg ctcaggggct gaagccggcc      660

gtccagatgt cctgcatgaa gattgtgggc aggaggctcg tcgggtggca ggctgtttac      720

gatattgggc tcgccgggga tcataacttc ctcctcgcta atggggctat tgctgctaat      780

tctggtgtaa aagttgctgt cctcgataca gggatatcca ctcatccaga tctaaatatt      840

cgtggtggcg caagctttgt accaggggaa ccgtcgactc aagatgggaa tgggcatggc      900

acgcatgtgg ccgggacgat cgctgcttta aacaattcga ttggcgttct tggcgtagcg      960

ccgagcgctg agctatacgc tgttaaagtc ctaggggcga gcggttcagg ttcggtcagc     1020

tcgattgccc aaggattgga atgggcaggg aacaatggca tgcacgttgc taatttgagt     1080

ttaggaagcc cttcgccaag tgccacactt gagcaagctg ttaatagcgc gacttctaga     1140

ggcgttcttg ttgtagcggc atctgggaac tcaggtgcag gctcaatcag ctatccggcg     1200

cgctatgcga acgcaatggc agtcggagct actgatcaaa acaacaaccg cgctagcttt     1260

tcacagtatg gcgcaggcct tgacattgtc gcacccgggg taaacgtgca gagcacatac     1320

ccaggttcaa catatgccag cttaaacggt acatcgatgg ctactcctca tgttgcaggt     1380

gcggccgccc ttgttaaaca aaagaaccca tcttggtcta atgtacaaat tcgaaatcat     1440

ctaaagaata cggcaactag tttaggaagc acgaacttgt atggaagcgg acttgttaac     1500

gcagaagcgg caacgcgt                                                   1518


<210>  556
<211>  2103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Cwa_RIR1

<400>  556
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcgtcgcgc cggagacaaa gatcctcaca      900

gacagggggc agatcgccat cgctgacgtc gcgggggaga aggtcaatat ttggaacggg      960

tcggagtggt ctgaggttct cgtgaagaag acaggcgaga accagccgct cctgaaggtg     1020

cacttctcaa atggcgagtc cctggactgc acttactacc acaagttcca tgtccaggag     1080

aactacaagg ggaaggtcaa gatcgttgag gctaaggacc tccaggaggg cgataagctg     1140

attaagtacc ggctcccact ggtggagtcc gagaatgaca tcgatttccc ttacgcctac     1200

accagcggct tcttctcggg cgacgggtct catgatggca tggggaagcc ggagattgac     1260

ctctacggcg agaagaagga gctcctgccc ttcgtcacgg ttaggaacaa gtactacggc     1320

gggtcatacg gcgacaagtc ctggcgcatc gagagggatg aggtggccgt ctacgacgat     1380

gttaaccagg accggatcgt gtgcaagctc ccgctggata ttcccgcgaa gttcacagtt     1440

cccgtgaatg gctacactat ccagagcagg ctggagtggc tggctggcct cctggacgcg     1500

gatgggacag tcgctaggaa cggcgacaat gagagcctgc aggttgcgtc gacccaccag     1560

cagttcctcc tggacatccg cctcatgctg cagacgctcg gcgtcgactc taaggtggtc     1620

aagatggatg agatggggta caggtcgctg ccagacggca agggcgggta ccaggattac     1680

ttctgccagg cgaagtaccg cctcctgatt tccagcaacg gcctcttcca gctgggcgag     1740

ctcgggctga agaccaacag gctccagtgg aatctgaggg agcctcagag ggaggcttcc     1800

cagttcatca gggtggagaa ggtcgagctc acctgccggt acgacgatac gtactgcttc     1860

tcagagccaa agaggcatct cggcatgttc aatggcatcc tcacagggca gtcaacatat     1920

gccagcttaa acggtacatc gatggctact cctcatgttg caggtgcggc cgcccttgtt     1980

aaacaaaaga acccatcttg gtctaatgta caaattcgaa atcatctaaa gaatacggca     2040

actagtttag gaagcacgaa cttgtatgga agcggacttg ttaacgcaga agcggcaacg     2100

cgt                                                                   2103


<210>  557
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Dhan_GLT1

<400>  557
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctcgctt cggacactct cgttcgcaca      900

tcggaggggg acaagccagt cgctgaggtc gctatcgggg actacctgct ggacgctgag      960

gacaagccag tcctctgcat gggcgctaac ccttcccaga ccgggcgcat gaaggagatc     1020

gcttaccagg acttcgattc gaagaagagg gtgtctttca agtgcacacc ggaccaccac     1080

ctggagctga cactcactga ttccactccc tccctcagcg gcaagtcagt cacctggttc     1140

tccaggtgca cgggggctca cctcagcgag gaggtgtcgg aggtctacct ggacaacatg     1200

gtttcgatct tctacaatga tctggttgac tcgacggatt ctgcggtgga caaggattcc     1260

attcacgagg ccgtggacct ggcgctggag gatcactacc ataggggcaa ctctgaccag     1320

tactcaatcc atctcaatga gtacatcagc cggattgccg ataaggagct gcagaacgag     1380

ccggagttca tccgggagtg cattcacgac gccgcgaatc gcttcgtcat cacctccagc     1440

ggcaacagga atattaagtc ggagtctttc gacgataagc tcctgctctc acgctccagg     1500

tcgtctacag ctgacagcga ttcggactac gtgatcactg acgcctccgt ccactctcat     1560

tcaaacaatt catccgtcta cctcgcctca ccagactcca tgatccctga tggcgctgcc     1620

aaccgcttcg agaatattgc gtccaagctg aaggagccag tgtgcaactg cggcgggatc     1680

cggaagattt tccgcagctt cggcaccacg gaggacgctg agctcgctta ctccctgctc     1740

ctgagcgagc actactacag gctggaccca cggttcgtca cagatggcta cactttccag     1800

gcctcggttg agcagtacga gaacatgtgc tctcaggagg tgcagaatat gcacctgaag     1860

ctctaccgct cacctctcaa gttcgtggag agggagcata actccgctga gctgccagtc     1920

gacccatact tcctgggcct ctggctgggc gatggggaca gctcggggac aactatcatg     1980

accacggatc gggagattgt ggtctggctc aactcctacg tcgagcgcct gaaccagaat     2040

aagccggagg gctgcttccc cctcaagctg accgagcagc tgatctacgg cgctgggcac     2100

acgtccaaga gcgggcatac aactaaggtc gacgttagga attacaagat ctcttcaggc     2160

gatgctttcg tgcggtcggg gacatactgg aacccgattt tcgacggcct caagaagctg     2220

gggctcctga acaataagag cgctggcatc ccccaggagt acatgaactc tgacgagcag     2280

aataggctct cagttattgc cggcctgatg gattccgacg ggtgctacgt gaagagccac     2340

aacacctacc gcttcaccca gctcacggag gaccataaga agatcgtcta cgatctgaag     2400

gagctcgccc tgagctgcgg cattaacacc acgggggtcg agctctcggt taagccgctg     2460

ggcttcaata agcacaagca ttctaccgag tatgtggtgt acctcggcaa cgggagccag     2520

aagttccagg agctcctgct cctgccacgg aagaagatgg agatcagcaa gaagcacgtg     2580

tcgctggacg cgcgcccttt cacggttagc gacgtggagg atggcgagtt ccgggctatt     2640

gaggtttcag ggggggtttt ccagctcgct aataggctcg tggttgctaa ttcaacatat     2700

gccagcttaa acggtacatc gatggctact cctcatgttg caggtgcggc cgcccttgtt     2760

aaacaaaaga acccatcttg gtctaatgta caaattcgaa atcatctaaa gaatacggca     2820

actagtttag gaagcacgaa cttgtatgga agcggacttg ttaacgcaga agcggcaacg     2880

cgt                                                                   2883


<210>  558
<211>  1944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Fsp-CcI3_RIR1

<400>  558
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgccagccat acgacgctct cgtttcaacg      900

ccatcggggc tcgttcctat cggggctctc gtggagacag acgcggtcgg catgaaggtg      960

ttcgatgcgc acggcctcac acaggtcatt gctactaaga gcaacggggt taaggacgtg     1020

ctgaggatct ggacccgcgc gggccacgct ctcgacgtca cggccgatca tctggtttgg     1080

aggtccacaa gcgctggcgc tggggctttc gtgccagctg gcgctctcag ggctggggac     1140

acactggagt ggcataggac tattgctcca ggcgaggggg agatcacgag ccgcgagatt     1200

gctgaggctg ctctcgctgg caggctgcag gctgatggct tcgtcgggcg ctacgctggg     1260

accaatgctt cgctcacgat cgaggcgatg accgttccaa cgaggctcta cgacgctcca     1320

ctgccagtgg tcgctgccta cctcaggtca ctgttccagg ctgatggcta cgtctcgcgc     1380

agggagaggt ctaccctcat cggcctggac atgatttccg aggggctgat caggggcgtt     1440

caggggctcc tggctaggtt cggcatcttc gccagggtgc ggagggaggc tgatccacgc     1500

cctgacaggc acgatctctg gtccctgggc attcagaacg ctggggacag gcggaccttc     1560

gccgatgaga tcggcttcct cgacccagtg aaggcggcta agctggaggc ttccttcgac     1620

cagccaggcc aggctgctaa gcctgtcaag aggctccaga tcgagaggat tgagccgagg     1680

ggcccgatgc ccgtctacga cattcagaca gattccgggg agtacctctc tgctgggctc     1740

agggttcata actcaacata tgccagctta aacggtacat cgatggctac tcctcatgtt     1800

gcaggtgcgg ccgcccttgt taaacaaaag aacccatctt ggtctaatgt acaaattcga     1860

aatcatctaa agaatacggc aactagttta ggaagcacga acttgtatgg aagcggactt     1920

gttaacgcag aagcggcaac gcgt                                            1944


<210>  559
<211>  1923
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Gob_Hyp

<400>  559
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgccagcctg cggggacaca ggtcgctaag      900

gttattaagg aggggaggtg gagggaggat tcggttattg agcaggttcc tattgagtca      960

ctccagccag gcgacagggt ggtctccttc gggaacgcga agatctaccg caggggccgc     1020

gctgtgacag ggattacttc ccggcgccac acaggcaatc tgcatagggt cgaggttggg     1080

gagttccgca ccagggccac gccagagcac aggttcaccg tccggttcga cccagctagg     1140

cctaaggctg gcctcctgta cctcatgagg aggggcgata ggtggagggt gggcgtctgc     1200

gggatgttca actcgcgcgg cttcggggtt tccgtgcggc tgagccagga gaggggcgac     1260

gctgcttggg tgctcggggc cttcgcgaca ctgactgagg ctaggatcgc cgagcaggtt     1320

gtgagctgcc ggtacggcat tccaaccacg gtctgggaga ccggcaggaa tcctggggct     1380

tcgtgggctc agagggacca ggctggcatc gatgccatct accagaggct cggcgtcgat     1440

aggatccggg ctggggttga caggctcctg agggatcacg gcctctctgc tgggctgcca     1500

ctcctggctg ccaacgagcc cggcaatttc tcgtgcaggc agtctaggca ggtggctgct     1560

tgcaacctgg tgccaggcgt catgcaggtc ccagttccaa cggctggcga gaggttcgag     1620

tggagggacc tcaccgctac gagcttcgag agggttcatg atctggaggt gtggagcatg     1680

gatgtggaga gggataagca ttacgttgcg gatggcatcg ttgtgcataa ctcaacatat     1740

gccagcttaa acggtacatc gatggctact cctcatgttg caggtgcggc cgcccttgtt     1800

aaacaaaaga acccatcttg gtctaatgta caaattcgaa atcatctaaa gaatacggca     1860

actagtttag gaagcacgaa cttgtatgga agcggacttg ttaacgcaga agcggcaacg     1920

cgt                                                                   1923


<210>  560
<211>  2298
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Gvi_RIR1-1

<400>  560
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcttcgctg cggggacgct gctgcatact      900

gagcagggct acgttccggt ggagcaggtc gtggcggggg tcgggacaag ggtttgcaca      960

caccagggct tccggaacat ctctgagcgc ttcgataatg gggaggccga ggttttcagg     1020

gtgaccacgc ggaagggcta ctccgtggag gtcactgcga accacaagat ggctcgcctc     1080

gacgagaatg gcgatctcct gctcgacgag ctctcacatc tgcaagtggg cgacaacctg     1140

ctcctgctcc tggggtccaa tccggtgacc gagaaggtcc ggctgcagtg catcccagct     1200

ggctaccgct ccagcatcga gattgctcag ccgcccgagc tcgatgagca gctggcttac     1260

ctcctgggct acgcctacgg cgacgggtgc gtcggcaggg gggctacata caactacctc     1320

agcctggctg tgtcgcacac ttacccgaat gtccgcgacc agctcgccgc gatcattagg     1380

gagaagttcg gcctgacaac taagatctac tcaggctccg gggcggtttg gaacctcctg     1440

gtgcattccg ccaatctcct ggattggctc aaggcgaacg gcctcctgaa gcagaaggct     1500

gcggacctcg ccatgccaga ggcgattctg cgctcgcctt cgtctgtggt cggcgctttc     1560

ctgtctgggt acttcgacgc tgatggctgc gtgaggggcg ggaagggcgg gtacgggttc     1620

gattgcacga gcaaggcttt cgtcggcgct gttcagctcc tgctcctggc cgaggggatc     1680

gtgtccaacc tccacaccac ggaccggagc cgccagggct ggcgcacaat ctacaggctc     1740

aatgtctgcg gcaccgagtt caagcgcagg ttccagacgc tgtgctgcag gtctgcgaag     1800

gttgtgcatt caccaatggt gctcggcagg gatgggaccg gcgggtaccc acctgctctg     1860

gttaggggcg cttcgtacca gagggtcgtt gctgtcggcg ggaagcacct cctgtacacg     1920

gcgctcctga aggtcatcga gaagacaagg actgctggca agcaggctct cgctgagagc     1980

ctgtgccagc atgtcaacta cttcccggac cccatcgtcg cgattgagtc ggttggcacg     2040

cagagggttt acgatattga ggtggagggc atgcatctgc tcggcaatgg catctacaca     2100

agcaactcaa catatgccag cttaaacggt acatcgatgg ctactcctca tgttgcaggt     2160

gcggccgccc ttgttaaaca aaagaaccca tcttggtcta atgtacaaat tcgaaatcat     2220

ctaaagaata cggcaactag tttaggaagc acgaacttgt atggaagcgg acttgttaac     2280

gcagaagcgg caacgcgt                                                   2298


<210>  561
<211>  2538
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hhal_DnaB-1

<400>  561
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctcgcct acgacgcgga gatcgttcag      900

gctgacgggg gggttaagac tattgagcag atcgttaggg agcggcgggc gcatctcgct      960

acggtcggcg ctgactggag gctgacatgg actgagccgt gcgattacgt tgacgatggc     1020

cacaagcccg tcttcgaggt taccacgcgc ctcgggcgca ggatcgagac aactctgaca     1080

cacccgttcc tcactgtcca tggctggcag aggctggagg acctcgctga gggcgatgct     1140

atcggggtcc caaggcagct gccagttttc ggccaggagc ccattaggga ctgcgaggtg     1200

aggctcctgg gccacctgat cggggatggc gggctcaccg gctcgccacc caggctgacg     1260

tctgggcagg aggcgatgac agctgacttc ctggaggctg tggatgcttt cggcggggtc     1320

gaggctaagc caatcagggc gtcccggagg acgcagagct gggtggtcgt tggcgctgct     1380

caggcccgcg ctgctgctag gtccagcttc gcttcactgg tcgacgccct cattaggagg     1440

tcccctctca ccggcagggc tatcgctagg aacctggggg tggcgccagc taccctcacg     1500

tactggaggc agggcgtgaa tgtccctgac gctgctatgg ttgggctcct ggctggcgag     1560

ctgggggttg atgtgggcga gctcaggcca gagcctgtgg ctcgcaggaa cgaccgcaat     1620

ccactgcagg cttggctcga taggctgggc ctcgctggga agtccgctca cgagaagact     1680

gtgccagact gcgtcttccg gctgcctcgc gagcagctcg ctaggttcct gaaccggctc     1740

ttctcgtctg acgggtgggt gacacatctg gctagcggcc aggggcagat tggctacacc     1800

acggtctcgg aggctctcgc taggcagatc cagcacctcc tgctccggtt cggcgttctg     1860

gctaagctca ggcataggtc cgtgcgctac caggacggca ggaggccagc ctggcagctg     1920

gatattactc acgcggagag catcctcacc ttcgctgagc agatcggcat tctggggaag     1980

gagcagcggc tcgcctctgt tgctgcttca gtgcgcggca ggaggaggca gtcgcacacg     2040

gaccatatcc cctgcgagat ttggcagttc atcgataggg ccaggggcga gtggacatgg     2100

gctgagctgg ctaggagggc tggggtcgct tcatccaata tccacgccta caggaggggc     2160

atgtctaggc agaggctggc tgctttcgct gacgctctcg gctcaaggga gctgaggcag     2220

ctcgcgagct cggacctgta ctgggatcgg atcgcctcca ttcgcccgct cggccataag     2280

caggtgtacg atctcactat tccagagact cataacttca ttgctaatga tgtttgcgtg     2340

cataattcaa catatgccag cttaaacggt acatcgatgg ctactcctca tgttgcaggt     2400

gcggccgccc ttgttaaaca aaagaaccca tcttggtcta atgtacaaat tcgaaatcat     2460

ctaaagaata cggcaactag tttaggaagc acgaacttgt atggaagcgg acttgttaac     2520

gcagaagcgg caacgcgt                                                   2538


<210>  562
<211>  2493
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hma_CDC21

<400>  562
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcgtgcatg gggatacaag ggttactctc      900

gctgatgggc atgagcggcc tattcgggag gtcgtggagt caaatctgga tgatccgaag      960

ccagtcgacg atggggtttg ggataccgtg gacttcgatg tcccttctct gcagtcagac     1020

ggcacagttg cgactcagaa cgctacgaaa gtgtggaagc ggaaggcgcc ggagacactc     1080

taccgcatca ggaccgctac gggcagggag ctggatgtca caccatcaca ccctctcttc     1140

gttcagtccg acgggaggtt ccaggctagg aaggctgagg agctggagtc tggcacccat     1200

gttgctgtgc ccaggaaggt ttcaactaac gcctgcaatg agctcgacgt caccttccgg     1260

cagtctcagg cccacaaccg catcgacctc gatctgccac cacagtggac gccagagctc     1320

gctaggctga tcgggtacat tgttgcggag ggctacgtgg agcagaggcc tgataatacg     1380

ggctacgtgt ccatcacaaa caatgaccgg gaggtgctgg acgatgccaa gagcgtcctg     1440

gagactctca acctgaatgt caccgagcgc tccagccacg aggggaagac ggcgagggag     1500

ctcctgtgca gcgctggcga gttcgtgtcc ttcctcgcca gcctggacga gacactcctg     1560

cagtcgtctg ctgagaggag ggtcccgcag gatattatga gggcttccga caacgtggtc     1620

accgggttca ttcggggcta catcgagggg gagggccatg tgtcaacgtc ccagcgcgag     1680

atcacagtcg cgagcatgtc gaagccgctc ctggaggacg tcaggaccct cctggttacg     1740

cagggcatta cagcccagct gcagccccgg aacaatgggt cctacaggct caggatctcc     1800

ggccagagct tccacgacta cgcggagcag atcggcttca ttactgcccg caagaccgag     1860

gcttgcaggc agttcgaggg gacgcatggc aacacaaatc tggacattgt gccgaacctg     1920

ggcccagagc tcaggcgcat ccgcgaggct ctcgggctga ctcagagcga gtgcggcctc     1980

ccaaggtcga cctaccagca ctacgagagg ggcaggagga atccctcgcg ggattctctg     2040

gagtcagtgc tcgacgcttt cgagactagg ctggccgaga tgaacaatga cactccaatt     2100

tcggataccg ctaggtctga cggcgggggc acgggctcgc tcaggcagga tctcaacggg     2160

ctggctgctc tcgtggaggg cgacatcgcc tgggatcgca tcgagtccat tgagcctatc     2220

gagcatgacg agaagtgggt ctacgatctg gagattgagg gcacacataa ctacctcaca     2280

aatggggtcg tctctcataa ttcaacatat gccagcttaa acggtacatc gatggctact     2340

cctcatgttg caggtgcggc cgcccttgtt aaacaaaaga acccatcttg gtctaatgta     2400

caaattcgaa atcatctaaa gaatacggca actagtttag gaagcacgaa cttgtatgga     2460

agcggacttg ttaacgcaga agcggcaacg cgt                                  2493


<210>  563
<211>  1689
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_MCM-1

<400>  563
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcgtttcgg gggagacaga catcgctctc      900

gtggagggca agaccgctac tatcggggag ctcgtggagt cggcgctgac agacccaaag      960

ccggttgacg atggcgtgtg ggacaccgcg gatttcaccg tgacgtcggc tatcgagacg     1020

ggcgagctca ttgagcggga cgtcacacgc gtttggaaga ggcagtcccc cgagacgatg     1080

cggcagatcc agattgctgg cgggaggagc gtgacagtca ctccatcgca ccccgttttc     1140

gtggagcata atgggtctta caccgctagg agggctgact ccctgagcgc tggcgagtca     1200

gtggctatcg ctgacgatgt cgccgactca cacccgattt ccgtcgataa cactgcgaat     1260

accctcaacc caaggtcgat gtctacgcct ggcatcacca cggacggcgg gctgtacagg     1320

acagggtccg atggcgggat tgtccatgcc gaggttggca aggaggacgt tactgattgc     1380

ctcacaactg acaggatcac cgctgtgaag accgtcacgc caacagctga gtgggtctac     1440

gatctggagg tggagggcac acacgcctac ctcacaaacg gggttctctc acacaactca     1500

acatatgcca gcttaaacgg tacatcgatg gctactcctc atgttgcagg tgcggccgcc     1560

cttgttaaac aaaagaaccc atcttggtct aatgtacaaa ttcgaaatca tctaaagaat     1620

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg     1680

gcaacgcgt                                                             1689


<210>  564
<211>  2136
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_PolB-2

<400>  564
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcttcactc ctgatacaaa tgttctgacg      900

cctaatgggg ttcgcaatat tcgggatctc acggtcgggg attcggttta ctcgctgaac      960

ccggagacca tgcagatgga gatcaagccg gtgacacaga ctcacgagta ccccgactac     1020

cagggcgacc tcatcgatat tcagacaaac gagatcgatt tccgcgtcac tccaaatcat     1080

aggatgctgg ttgaggctac cggcacggac accacgtcca ccaacgacta cgatttcatc     1140

gaggccggga atctcgatat ttccagccgg tacgagctgc ctcacggctg gtccgttgac     1200

catacggata gcctcggggc ctacatcgac ctgattaccc tcctgaggga gcagtcagac     1260

acgtacaacg tcctctccga tggcgggatg acaactgctg ctacggctga catcaatcac     1320

aacaatgtca cccgcagggt tgactctgat acgttcgtgt cactgattgg ctggtatgtg     1380

gctacagggc gggtctcgcg cactcagaac ggctctgaca gggtctacct ccagctgtcc     1440

cagacaaata ctaaggcgcg gacccagctc acgatgctcc tggacgagct gggcgtggac     1500

tggcaggctg ataacgagaa gatccacttc gtgtctcatg tctggacgga gctcttcgac     1560

accacgtgcg gccgcacaga gaagaacaag cacatcccgg agctgatttt cgacgcttca     1620

gcctcccaga agagggcgtt cttcgatgct atcattaacg gcagcggggt caagaatgac     1680

gattcgtacc agtaccacac ctcgtctgag gacctcaggg acgatatcct ccggctgtgc     1740

gttcatatcg gcattgtggc gcggtacgac tacatcaacg atgagtcctg gcgcattgag     1800

tgcaccgaga cggccaatcc cgacttcaca ctgactcata gcggcaggca gtcgacagct     1860

gaggatgggg tttactgcgt gactgtggcg gataatcaga ctctgctcgc cgggaggaat     1920

ggcaccttcc agtggacagg caactcaaca tatgccagct taaacggtac atcgatggct     1980

actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa agaacccatc ttggtctaat     2040

gtacaaattc gaaatcatct aaagaatacg gcaactagtt taggaagcac gaacttgtat     2100

ggaagcggac ttgttaacgc agaagcggca acgcgt                               2136


<210>  565
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_RIR1-1

<400>  565
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctcactg cggactcaac agtcatgctc      900

aaggagaagg ggatggtctc ggtctcggag gtggagacag gggatcagat cgctcagcgc      960

tccgacacag gcttccagta caagccggtg gaggagactc acgcgtacga gaacgctgag     1020

acactcactg tcaccctgac gaacggctgc tctatccgcg ggaccccgaa tcacaggctc     1080

atggtcgacg atgagtggac gcgcatcgac gagattcagc ccgatcagga ggttcattac     1140

acactcggct ggctgaggga gactaaccag tccccgccca agctccactc tcagtcacat     1200

accacggtga atcagacagc tgactccatc agcccggatt ccagcgagcc cattgagctg     1260

tcggagtctg agaacgcgga cacgggcaac aggcacaatt ctgctgttgc cgtgaagcag     1320

tcacggacac agactcagct gatcagcgac gaggtggtct cgcggccaga gcacaccagg     1380

aggcctgatc agctctccga ggagctggct gagctcctgg gcctctggat cgacacgggg     1440

ctgtggcatc agagcggcgt ccagttcaac gttgagcgcg agaatatcgc ggagtacatt     1500

gaccagctct cacagcagct gttcgatacc ccagctgcta tctccgacac ggatggcacc     1560

tacacggtgg acattacaga tcataagctc aaggagtggt ggaaggctaa cttcggcggg     1620

aagccagacg gcactcagtc gtcttacgtc ccacagatga tcaaggaggc ccctacaaat     1680

gttattgagg cgttcctgag ggggtgcttc actgctgagg gcgggctcag gaaggacatg     1740

aggccacggc tgtgcacctc atccgaggat agcatcgacg atattgcggt cctcatgatg     1800

ggcctggggt accctgtgga gaagtcggtc atcaggaacg ctgacggcga gccgtactac     1860

tcggttatgc ccgctaccga cgatgggctc tctgccttcc tgcacgacgt gggcttcatc     1920

gatgagcggc gcgagatcgg gctctccaac attgagagct cggatagccg ggccctgaac     1980

aatacccata agatcgaggt tgagtcaatt gtggagtccc cacctgcgac ggtctacgac     2040

attacagtgg cggataatca tgagtacgtt acagatggca tcatttcaca caactcaaca     2100

tatgccagct taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt     2160

gttaaacaaa agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg     2220

gcaactagtt taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca     2280

acgcgt                                                                2286


<210>  566
<211>  2376
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Hwa_RIR1-2

<400>  566
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcgtggagg agaatagcct ggtttctacc      900

gatgaggggc tgcggcctat caaggatctg gacaatacta ctgcggagtt cgagcagtgg      960

gacgagatcg atgtcggcgt taccacggac ggcgggacca agacggctac agctgtttac     1020

gataacggct tcgccaatgt gcgccagatc cagaccgaga gcgggttcaa cattgctgct     1080

accccaaatc accggttccg cacgctgtcc agcgacggca cttacacctg gaaggaggct     1140

ggcaagttcg agtccgggga ccgcgtgatc ctgcagagga acaccttcga tgctggctcc     1200

cgcgtgtccc tggaggctaa tgagagggct gacgatgccc aggacacaac tgagggccca     1260

gagctgccag ggaggatgac gtccgagctg gccgagttcc tcggctactt catgggcagc     1320

gggtacatct cggacgagac ccatgcttcc gtggatctgg tggtcgacag cgatgccacg     1380

gagctcaact catacctgtc caatctcggc gagcagctct tcaggattac cccggccgtc     1440

gagtctcagg agatgtcaca ggttctgtcc ttccgggact gccacctcag ccgctacttc     1500

gaggataacg gctggaagaa gacggacaca ggccataatg gggatgcttc ggctgctttc     1560

gtcccagagc agatcctgga gggcgacgag caggttgtga acggcttcct caggggggtg     1620

ttcgaggcga ttgggacggt ctcggagaag atcgagattc tgaccacgtc tacaactctg     1680

gctgaccagc tccagagcct cctgctctcg ctgggccacg tgttcacccg ggatagcacg     1740

aagctcgtcg agacaaacaa ttaccatgac gatcagctga ggcagaggct ctgcggcgct     1800

actaggaggg aggacgagcg gttcatgaac gagatcgggt cactcattga gccagatgag     1860

ctgaacctct ccacacgcgc ggacaagaat gatacttacc cttcgtctgt tatcgaccac     1920

gtgcagacac tggacggcta cgattcagtg tccgagagcc tcaagtctcg cattaaccag     1980

tcacaggtcg acgggacggt tagcaggaag ctgatcaagg atattgaggc ggagactgct     2040

gagaccgtct cgatcgccga ccatgagctc acaggcttct acgcggctac tgtggagtct     2100

gtcacggagg acacagcgta cactaaggat atttcagttc caagcaacaa cacatacatc     2160

gccgacgggt tcgttactca taattcaaca tatgccagct taaacggtac atcgatggct     2220

actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa agaacccatc ttggtctaat     2280

gtacaaattc gaaatcatct aaagaatacg gcaactagtt taggaagcac gaacttgtat     2340

ggaagcggac ttgttaacgc agaagcggca acgcgt                               2376


<210>  567
<211>  2346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Kra_DnaB

<400>  567
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctcactg cggggacaag ggttctgcgg      900

gctgatacgg gggcggagac tactatgggg gagctgttcg cgctgcaggc tagggacgtt      960

ccggtgtggt cactcgacga gtccctgcgc tacgtccgca ggcacctcac tagggttttc     1020

ccaaccgggg tgaagccagt cttccggctg aggactgcta gcggcaagac tgtccgcgct     1080

accgctaacc atccattcct cacctacgat gggtggaagc ctctcggcga gctgtcggtg     1140

gctgacaggc tggcggttcc gaggcacgtg ccagctccag agagggtggc ttcatggacg     1200

gacgatcagg tcctcctgct cggccatctc atcggcgatg ggtccttcgt caagaggcag     1260

ccactccgct acgctagcgt tgacgaggct aacctgtcgg ctgtgacgga ggctgctgct     1320

aatgccttct ccattgtcgc ggttcgggac gagtacgctg ctgctaggtg caccacgctc     1380

aggctgccag ctccttacag gctgacccac ggcaggagga atccactcgc tgcttggctg     1440

gacgagctcg gcctgttcgg gctcaggagc tacgagaagt tcgtcccgca ggaggttttc     1500

cacctgccca agaggcagat cgctctcttc ctgcggcatc tctgggcgac tgatggctct     1560

gtgacgctga caaggcagtc acgcggcggg aggatctact acgcctcgac atctctccag     1620

ctgattcagg acgtctccag gctgctcctg cggttcggca ttagcacgag ggtgcggaca     1680

actaccccaa agggggacca caggcctggc tacacactcg atgtttctgg cgtggacgat     1740

cagaggcggt tcctgcagga gatcggcgtc catggggcca ggggcgctac cgctgacagg     1800

ctcctggagg tcatcaggga tgtctccgcg aacacgaatg tcgacacagt tcccaggcag     1860

gtttgggacg atgtgcgcag gctcctggtg gagaaggaga tgacgcacag ggagttcgct     1920

gctgctatgg ggacatcgtt cggcgggtcc agcctctgga agcatgctcc atctcgcgag     1980

aggctcggca gggtggccca ggtcctggac tcggccgagc tcgatgttct ggcggtgaac     2040

gacgtcctgt gggatgaggt ggtcgcgatc gagcctgacg gcgaggagca ggtctacgat     2100

gctactgttc tcggggggca caacttcgtg gcggatggca ttgctgttca taattcaaca     2160

tatgccagct taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt     2220

gttaaacaaa agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg     2280

gcaactagtt taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca     2340

acgcgt                                                                2346


<210>  568
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mca_RIR1

<400>  568
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcgttacgg ctgacacatg ggttatgacg      900

gcctcggggg ctaggcaggt tcgggatctc attgacaggc cattcgaggc ggtcgtggac      960

ggcgagtgcc acccaacaga gtcccgcggc ttcttcttca ctggggataa gcctgtgctc     1020

aggctgtcga cggctgaggg ccacacactc aggctgactg cgaaccatcc ggttctcagg     1080

gtgtccaaga tgaccaggca gctgcgggag acggagtggg ttaaggctgg cgagctcagg     1140

ccacacgaca agatcgtcct ccacgatcat agggctctgc catcctggga cggcgctcat     1200

accgaggctg agggctacct gatcgggctc ctgattggcg ggggcaccct cacgagggac     1260

aaggctatcc tgtctatttg ggatgctgct gctccaaagg tggctaacgg gggcggctca     1320

gtcccagctg ctggcgtcgc cggggttatg agggctgctg agctcgctgc tcggaccctg     1380

ccacaccgca cggacttcaa tggctggcag accacgatgg agggcagggg ggagtaccac     1440

atggctacag gcgccctcca tactctcgct ctggagctcg gcctgacacc aggggataag     1500

cgcctcactg cgcctctgga gacaacttcc agcgctttcc acaggggcct cctgaggggg     1560

atgttcgacg ccgatggctc ggttcagggg tctcagagga agggcgtgtc catcaggctc     1620

ccacagaccg acctcgggaa cctgcagacg gtccagagga tgctcctgag gctgggcgtt     1680

gctagcacca ttcatcagaa taggaggcca ggcgggacca aggtcctccc agatggcgag     1740

ggcggggcta aggggcactc atgccaggcc gcgcatgagc tgatcatttc cggcgagaat     1800

gtggtcaggt acgctgagcg gatcggcttc gccgactcgg ataagatgga caggctcacc     1860

gctctcctgc agaggtacag gcacacgagg catgctgaga ggttcatcgc gacagtgcag     1920

agcctggagg acgatggcat ggaggccgtc tacgatgtta cagtggcgga cgttcatgct     1980

ttcgatgcta atgggctcta cgttcataat tcaacatatg ccagcttaaa cggtacatcg     2040

atggctactc ctcatgttgc aggtgcggcc gcccttgtta aacaaaagaa cccatcttgg     2100

tctaatgtac aaattcgaaa tcatctaaag aatacggcaa ctagtttagg aagcacgaac     2160

ttgtatggaa gcggacttgt taacgcagaa gcggcaacgc gt                        2202


<210>  569
<211>  1557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Memar_Pol-II

<400>  569
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcttcgcgg gggacactga gattactgtt      900

tcggacgggc ggcgctggat gtcgctccct attaggcagt tcgttactga gaatttcgac      960

atctcaaagc cgggcctcga tcacgttggg acattctact ccgacccaag gcagccattc     1020

tacgtccgct cgattgattc tcagggcaag acaagcctca agcgggtgac ttccgtcagc     1080

gttcacaggg ctccagctca tctggtccgg ttcgctacca ggagggggag ggtcctcacc     1140

gttacgcctg accatgcgat gctggtgtgg gacacggatt acctccgcaa gatcaaggct     1200

ctggaggtgg ctgtcggcga cagggttcca gtggaggagg gcgggctcgt ggtcgctgat     1260

gaggttgtgt ctagggagac ggtgcaggct ctggacgatc gggtctactg cctcactgtg     1320

gcggagaatc atactctcgt tgctaatggc atcttctgcg ggcagtcaac atatgccagc     1380

ttaaacggta catcgatggc tactcctcat gttgcaggtg cggccgccct tgttaaacaa     1440

aagaacccat cttggtctaa tgtacaaatt cgaaatcatc taaagaatac ggcaactagt     1500

ttaggaagca cgaacttgta tggaagcgga cttgttaacg cagaagcggc aacgcgt        1557


<210>  570
<211>  1872
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mex_helicase

<400>  570
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcttcgctg cgggcactct catcaagaca      900

ccaaaggggc ctgttcctat tgagcagatt cagtcggggg atctcgtttt caatgcgatc      960

ggcattgggg tggtcgaggg catcgtgtgc cagcagaagc agaccattac gctggagctg     1020

tctgacggca catcaatcgt ctgcactcac gatcatccat tcttctgccc tcgcggctgg     1080

gtcgctgctg gcgacctgga ggttggctcc gggctgttca gccacgagga tctccgcagg     1140

ctgtggtcgg gcggggcttc tctcggcctg gagtccgggt ccagcgacgg caggggggct     1200

gttcgctcgt ctgaggtgct cctgaggatc ctcagggagg aggctcgcga gccagatgct     1260

ggctactgcg ggccagccga ggacgtgcgc aacgcgtcta ccgatagggc tcatgctgag     1320

ggcgcttggt ggcagtggca ggctgacccg attgcgtcag atgaggctgc taggtccgct     1380

ggcaggaggg tcgctgaccg cgttagggac gaggatagga gggaggctag gccagagcca     1440

accgctgtcc tcctgcagga caggcactgc gagccactgg ctaacgatcg gaataggagc     1500

ggcagggagc attcatcccg gggcacgggg gaggctgagg gccagcggca gggggacgtg     1560

ccatgctcgg tccgcgttgt gagcatctcg cgcgaggaga ggggcgggcc tgaggcggtg     1620

tacaacctca gggtttcagg gcatccaagc tacttcgctg ggggggttct cgttcataat     1680

tcaacatatg ccagcttaaa cggtacatcg atggctactc ctcatgttgc aggtgcggcc     1740

gcccttgtta aacaaaagaa cccatcttgg tctaatgtac aaattcgaaa tcatctaaag     1800

aatacggcaa ctagtttagg aagcacgaac ttgtatggaa gcggacttgt taacgcagaa     1860

gcggcaacgc gt                                                         1872


<210>  571
<211>  1557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mhu_Pol-II

<400>  571
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcttccatg gggacacact cattgagatc      900

tacgctgacg gcattctgga ggagattccg atcaggcggt tcgttctgga gcatctggat      960

ctctcgcagg ctggcgtgga cgctctgggg acgttctacg ctgatccggt ccggccagct     1020

cacgtgcgct ccgtcgacac aggcgggatc ccacacctcc gcaagattac ttccgttagc     1080

gtgcataagg cccctgcgaa cctgatccag ttctcgacct ctaggggcaa gaatctcctg     1140

gtgacgccgg atcatgctat gctcgtttgg gacgtgtcct acctccgcaa gatcagggcc     1200

ctggaggtca agattggcga cgctgtccca gtttgggagt caggggtggt catctccgac     1260

aggatcgtca gcattgatta cgttccctgc gaggacgagc gggtgtactg cctcactgtg     1320

gatagggatc ataatgttgt gggcaatggc atcttcactg ggcagtcaac atatgccagc     1380

ttaaacggta catcgatggc tactcctcat gttgcaggtg cggccgccct tgttaaacaa     1440

aagaacccat cttggtctaa tgtacaaatt cgaaatcatc taaagaatac ggcaactagt     1500

ttaggaagca cgaacttgta tggaagcgga cttgttaacg cagaagcggc aacgcgt        1557


<210>  572
<211>  2298
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Mja_PEP

<400>  572
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcattgagg gggacgctaa gattctgacg      900

gatcgggggt tcctgaagat gaaggaggtt tacaagctcg tgaagaatgg ggagaagctc      960

aaggtcctcg gcctgaatgc tgagacactg aagactgagt ggaaggagat cattgacgct     1020

cagaagaggg aggctaggcg ctacgagatc ggcgtgtacc gcaagaataa gaacaccaag     1080

gacacgatca agattacacc ggatcacaag ttccccgtgt tcgtcaacgg cgagctcagc     1140

aaggtgcagc tgtgcgacat cattgataac aatctctcag tcctgtccat cgactacatt     1200

ccaatgatcg aggagaagta cgagtccctc gctgaggtca tgtacctcgg cggggctgtc     1260

ctgagcgatg gccatatcgt tcggaggaac gggaagccaa ttcgggtccg cttcacacag     1320

aaggacactg aggagaagaa ggatttcatc gagaaggtta agggcgacgt gaagctcatc     1380

ggcgggaatt tcatcgagat ttcgaaccgc aacaatgtca tcgagtacca gacctctagg     1440

aagattccgt cagagatcct gggcttcatt gaggttaata ttaacacaat ccccctctac     1500

gccactaagg acgagatcgc cgatctgatt gcgggcttcg ttgacggcga tgggtgcctc     1560

tccgggaaga ggagggtgga gatctaccag aactccagcc acattaagaa gatcgagggc     1620

ctcatcgtcg ggctctacag gctgggcatc attccgaggc tgcggtacaa gcggtcgtct     1680

accgcgacga tctacttcaa caacaacctg gagaccatcc tgcagcgcac gcgcaggatt     1740

aagctcgaca agctgaagga gttcaagaag ccagtggagg acaagaagct gatcgatatt     1800

tcgcagatcc tccctgagct gaaggagttc gactacaagg gctacctcta caagacctac     1860

aaggagaagc tgttcatcgg gattaacaag ctggaggagt acctgtctaa gatcgacaag     1920

gatggcattg agcgcatcaa gcagaagatc aagctcctga aggagagcga catctactcg     1980

atcaggatta agaaggtcgg cgaggattac ggggaggtct acaatatcac ggttaaggcg     2040

gagaacgagt tcaatcataa ctacgtggtt tggactaagc attacacacc tatcgtggtt     2100

ttcaactcaa catatgccag cttaaacggt acatcgatgg ctactcctca tgttgcaggt     2160

gcggccgccc ttgttaaaca aaagaaccca tcttggtcta atgtacaaat tcgaaatcat     2220

ctaaagaata cggcaactag tttaggaagc acgaacttgt atggaagcgg acttgttaac     2280

gcagaagcgg caacgcgt                                                   2298


<210>  573
<211>  2013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:MP-Be_gp51

<400>  573
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgctcgtgga caaacgctag ggcggttaca      900

aggcgggggt tcgtgcatgt ggatgatctc actactgatg atgaggtcat gtcggtcgac      960

gatcagggca ggacaatctg gcagcagatt gacgaggtgg tccggttccc gttcagcggc     1020

acgctctact cgctgggcgg gagggagatc aacgctacca ttacggccaa tcaccgggtt     1080

gtgggcctca accgcgagaa gaccaagtgg gttgagcata caccaacttc cctgcctggc     1140

aacaagatgt gggtgtacac cgctggcgag gggagcaatg aggactaccc gctcaccgat     1200

acggagatca ggctcgctgt gtggggcctg acagactcgc acaggtctcc cgatggccgg     1260

tggactttct accagtccgg ggagaaggcg gagcaggtca ggaagctcct ggctgacgct     1320

ggcattgagt acagggagag ggctaggaac aggggcatca ccgagattga tgggaaggtc     1380

ctcaaggcgc cgcccaagac gcagtacgag ttctcgctcg gcaaggttca ggagctggac     1440

gatctcctgg acagggggag gagcgagctg ccaacatgga ctctctccct gagccagagg     1500

caggctaggc tcttcctgga ggagtacagg ttcaccgacg gcacggatac cacgtcagct     1560

ggggactcct acgtcctcta cgtttgcaag gatcgcatga gggagcagct ccagatgctg     1620

gctgctgcta acggcctcag ggcttccaca actgagtaca ggccagggca ttggaggctg     1680

aacatctcta atagggcgct ctcaggcctg tacaagaata ccgtggagga ggtcgcttac     1740

gagggggaag tgtggtgcct gcgggttcca aatggcaggt tcttcattga ggatgggggc     1800

aagattcatc tcacgggcaa ctcaacatat gccagcttaa acggtacatc gatggctact     1860

cctcatgttg caggtgcggc cgcccttgtt aaacaaaaga acccatcttg gtctaatgta     1920

caaattcgaa atcatctaaa gaatacggca actagtttag gaagcacgaa cttgtatgga     1980

agcggacttg ttaacgcaga agcggcaacg cgt                                  2013


<210>  574
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Nsp-PCC7120_RIR1

<400>  574
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctccctg aggatgcgct ggttcatacc      900

gctaaggggc tggtccctat tcgggatgtt caggtcgggg atctcgttca gacaccgctc      960

ggcttccgca gggtggtcga caagttcgat cagggcttcc aggacgtgta cgagatcgag     1020

actaacgcga cctacccacg cgctacgctc aatcacaggc aggctgtcct ggaggacgct     1080

aagggcggga tcgtttggaa gcatattgct tcgctggagg ccggcgatag gctcctgcac     1140

aacaagcagg tcctcccggg cactgttacc catctgcccg cggacttcac tgagagcagg     1200

ccatcacact cccggaccgc caagtcgttc gttgtgcctg agctcacggc tgaggtggct     1260

tggctgatcg gcttcacaca tggcgacggc tacgtggctc tcggcaggaa caagtacgat     1320

aagccgtacg ggcgggttga gtggtccatg aactccctgg acgctgaggt cacctcccgc     1380

atccaggcta agattgatgc tgctctcgct ctgttcggcc tctccgctgt ccacagcatc     1440

acgaagggcg agaacacagc taagagcatc tgctccagca ttcggctggc cgagtacttc     1500

caccgccata tcaagcagcc aaatattcct ctcactgtgc cgtcattcat cctgcagggc     1560

tccgtcgaca ttagggctgc ttacctcgct ggcctgatgg actccgatgg ggctgtgaac     1620

aataggccac cacacctcat cacatcggtg taccggtctt tcattcgcca ggtctcggtc     1680

gttctctcgt ctctgggcat cgccgggagg ctgaccacga cataccccca gaactctaat     1740

tggcaggtca agtacaacct cacgatcccg gcgctgaagg agcgctacaa tgctctcatt     1800

tctccccatt cagccaaggg cgagctcagg caggggctga agatgtacgg cttcacggtt     1860

ccaggggccg tgatgcggga gacgtacaca tactctgaga tgagggagat gggcttccag     1920

gggtcacgga cagttgacgc caactacgag cgctacgtgg cggaggctga catctccctc     1980

gatattcctg tgactgtcaa gggcctgggg agctacgatc acgtgcagac ctacgacatt     2040

gaggttgatg aggctcattg cttctactgc gatggctacc tcacacataa ttcaacatat     2100

gccagcttaa acggtacatc gatggctact cctcatgttg caggtgcggc cgcccttgtt     2160

aaacaaaaga acccatcttg gtctaatgta caaattcgaa atcatctaaa gaatacggca     2220

actagtttag gaagcacgaa cttgtatgga agcggacttg ttaacgcaga agcggcaacg     2280

cgt                                                                   2283


<210>  575
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pab_RIR1-3

<400>  575
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcgtggtcg gggagacaag gattctgacg      900

cctgagggct acatcaaggc tgaggagctg ttcaagctcg ccaaggagcg gggcaagatg      960

gaggccatcg ctgtggaggg cattgctgag ggcggggagc catacgcgta ctctctggag     1020

atcctcctgc ctggcgacaa gcaggtcaag tacgagaccg ttcacgggaa cgctgtggag     1080

gtcgccgatc cggtttcagt gcccgcctac gtgtggaagg tcggcatgaa ggaggttgcc     1140

cgcgtgagga caaaggaggg ctacgagatc accgccacgc tcgaccataa gctgatgact     1200

ccggagggct ggaaggagat caaggacctg aagccagggg ataagattct cctgcctagg     1260

ttcgaggtgg aggaggactt cggctccgag agcatcgggg aggatctcgc gttcgtcctg     1320

ggctggttca ttggcgacgg gtacctcaac gttaaggata agcgggcgtg gttctacttc     1380

aatgctgaga aggaggagga gatcgcctgg aagatccgcg agattctggc taagaggttc     1440

gagatcaagg ccgagccaca ccgctacggc aaccagatta agctcggcgt cagggggaag     1500

gcgtacgagt ggctggagtc catcgttaag accaacgaga agaggatccc ggagattgtg     1560

taccggctca agcccaatga gattgcctca ttcctcaggg gcctgttctc cgctgacggc     1620

tacgtggaca atgatatggc tatccgcctc acgtcgaagt ctcgggagct cctgcgcgag     1680

gtccaggatc tcctgctcct gttcggcatc ctgtccaaga tctacgagag gccgtacaag     1740

cgggagttca agtacaccac gaaggacggc gaggagcgca catacacaac tgaggggtac     1800

tacgagctcg tgatcgcgaa ctactcccgg aagatcttcg ctgagcgcat tggcctggag     1860

gggtacaaga tggagaagct cagcctggag aagatcaagg tcgacgagcc cattgtcacc     1920

gttgagtcgg tggagatcct cggcaagaag ctggtctacg acttcactgt tccagagcat     1980

cacatgtaca tttccaatgg gttcatgagc cacaactcaa catatgccag cttaaacggt     2040

acatcgatgg ctactcctca tgttgcaggt gcggccgccc ttgttaaaca aaagaaccca     2100

tcttggtcta atgtacaaat tcgaaatcat ctaaagaata cggcaactag tttaggaagc     2160

acgaacttgt atggaagcgg acttgttaac gcagaagcgg caacgcgt                  2208


<210>  576
<211>  2628
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pfu_KlbA

<400>  576
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt gctctctacg atttctcggt tattcagctc      900

tctaatgggc ggttcgttct catcggggat ctcgtggagg agctgttcaa gaagtacgcc      960

gagaagatca agacctacaa ggacctggag tacattgagc tgaacgagga ggataggttc     1020

gaggtggtct cagtctcccc ggacctcaag gcgaataagc acgttgtgtc tcgggtgtgg     1080

aggaggaagg tccgcgaggg ggagaagctg atccgcatta agaccaggac gggcaacgag     1140

atcattctca cacgcaatca tcccctgttc gccttcagca acggggatgt cgttaggaag     1200

gaggctgaga agctcaaagt gggcgacagg gttgccgtga tgatgcggcc gccctcacca     1260

cctcagacta aggcggtggt cgacccagct atctacgtta agatttccga ttactacctg     1320

gtgccaaacg gcaaggggat gatcaaggtc cctaatgacg gcattccgcc cgagaaggcc     1380

cagtacctcc tgtctgtgaa ctcatacccc gttaagctcg tgagggaggt cgatgagaag     1440

ctcagctacc tggctggggt catcctgggc gacgggtaca tttccagcaa tggctactac     1500

atctcggcga ccttcgacga tgaggcgtac atggacgctt tcgtctccgt tgtgagcgat     1560

ttcatcccaa actacgtgcc ttccattagg aagaatgggg actacacaat cgtcactgtt     1620

ggctctaaga ttttcgccga gatgctctca cggatcttcg gcattccgcg cgggaggaag     1680

tccatgtggg acatccccga tgtcgttctc agcaacgacg atctgatgcg ctacttcatc     1740

gccggcctct tcgacgcgga tggctacgtg gacgagaatg gcccgagcat cgtgctggtc     1800

accaagtcgg agacggtcgc caggaagatc tggtatgtgc tccagcggct gggcatcatt     1860

tcgacggttt ctcgggtgaa gtcgcgcggc ttcaaggagg gggagctctt ccgggttatc     1920

atttctggcg tggaggatct cgctaagttc gccaagttca tcccactgag gcactcccgg     1980

aagcgcgcta agctcatgga gatcctgcgc acaaagaagc cttacagggg caggcgcact     2040

tacagggtcc caatctcgtc tgacatgatt gctccactga ggcagatgct cgggctgacc     2100

gtggctgagc tctcaaagct ggcctcctac tacgcgggcg agaaggtcag cgagtcgctc     2160

atccgccata ttgagaaggg gagggtgaag gagatcagga ggtcgacgct gaagggcatc     2220

gctctcgctc tgcagcagat tgctaaggat gtgggcaacg aggaggcttg ggtcagggct     2280

aagaggctcc agctgatcgc tgagggcgac gtctactggg atgaggtggt cagcgtcgag     2340

gaggttgacc cgaaggagct gggcatcgag tatgtgtacg atctcacagt ggaggatgat     2400

cataactacg ttgctaatgg cattctcgtt tctaattcaa catatgccag cttaaacggt     2460

acatcgatgg ctactcctca tgttgcaggt gcggccgccc ttgttaaaca aaagaaccca     2520

tcttggtcta atgtacaaat tcgaaatcat ctaaagaata cggcaactag tttaggaagc     2580

acgaacttgt atggaagcgg acttgttaac gcagaagcgg caacgcgt                  2628


<210>  577
<211>  2394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pho_IF2

<400>  577
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctgctgc cggaggagcg ggttattctg      900

cctgactacg ggcctattac tctggaggag ctcttcaata tgacaaagga gacagtgttc      960

aaggacgagg agaaggaggt ccggaagctc ggcatccgca tgccagtggc tggcgtcgat     1020

gggcgggtgc gcctgctgga gggcccctac gtttggaagg tgcgctacaa ggggaagatg     1080

ctcagggtca agctgaagga ctggcacagc gtggctgtca caccagagca tcccttcctc     1140

accacgcggg gctgggtgcg cgctgaccag ctgaagcccg gggattacgt tgccgtgcca     1200

aagatcctcc ctgggaagga cgataaggag aagttcctcc agtatgtgca cgagaagctg     1260

aagggcaagg ttcatattaa gctgccgtcc agcgacgagg agtgggagac attcttctac     1320

ttcgccggca ctatcttcgg gcgcgagaac tcggtgaatc cagagggcct cacccacgag     1380

gtcaaggctc tcctggagct cttcaaggtt ctgttcgagt acccgaggga ggtcctccgg     1440

gttctgttca tggccccggt gcgctacgtg gcgaacttcc tccgcggctt cttcgacatt     1500

aacggctacg tcaatgggga ggagctgagg gtcgaggtta ggggggctcc acatgaggtt     1560

ctggaggagc tctccctgat cctcctgagg ctgggcatcg tgtccaagat ctaccctacg     1620

agcctggcta tttcgggcag gaggaacctg gagctgttcc ggcgctacat cgggttctcg     1680

gagaagcaga aggccaagga gctggagggc atcattaggc ggtctgagaa ctcagagtcc     1740

tacccaattt tcgaggagct gcgcaggatc aggctcctgt tcggcttcac ccgggcggag     1800

ctctcgtcta cgatcccact gtactctaag tacgagtcaa aggaggctcc ttcatacgag     1860

atcctcatga agattctgaa tacaatcgag aaggggtcta aggacctcaa caagaagatc     1920

actattctgg agggcagggt gcgggatcac gagtacattg aggagttcaa gcgcgagggc     1980

ctgatcaagg acgggaagct caccgagctg ggcaaggagc tcctggaggt ctggcgcaac     2040

agggagttcg actccaggga tgtcaactac ctccggaata tcattgagaa cttcgttttc     2100

ctgccggtgg agaagatcga ggagttcgag tacgatggct acgtctacga cgttactaca     2160

gagactcata atttcattgc taatggcatc ctcgttcata attcaacata tgccagctta     2220

aacggtacat cgatggctac tcctcatgtt gcaggtgcgg ccgcccttgt taaacaaaag     2280

aacccatctt ggtctaatgt acaaattcga aatcatctaa agaatacggc aactagttta     2340

ggaagcacga acttgtatgg aagcggactt gttaacgcag aagcggcaac gcgt           2394


<210>  578
<211>  2292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pho_r-Gyr

<400>  578
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcgttaccc cagacacgct ggtttcgctc      900

tcggacgggc ggattattga gatcagggag gcggtggaga actcggagga gtcgctgctc      960

gggatcaacg gcctgaagcc gaaggaggcc aaggcgctca agttctggga gatcgactgg     1020

gatgggccga tcaaggtcat caagctgaag aatggccacg agatcaaggc taccccagac     1080

catgggctcc tggttatgag ggatgggaag atcggctggg tgtcggctaa gaacattcgg     1140

gagggcgact acgtcgcctt catctacaat ctcgggcacc gcggcgggaa gaagtacacg     1200

ctcccccagc tcctgaagga gctgggcatc tccgagtacg agaactccag ctcgcaggag     1260

ctcaacaatc gcgagcagga gatggactcc aagcagatca gcattgagct ggatgagagg     1320

ttctggtaca tcttcggcgt gattctcggc aaggggaccc tgaaggggga caaggtggtc     1380

atcttccaga aggatgtcaa gccggttatt gaggaggcgc tgcccttcgt ccggatcttc     1440

gagtcggctg accacatcgg cttctctcat ctcattctgg ctgaggtctt ccgcaggctc     1500

ggcgttgggg agggcaagct ccactccctg gtgttcggcc tgagggagga gtacatcaac     1560

gctatgattg ccgggtactt cgacgctagc ggcaccttcc tcaggagggc tgtcctgacg     1620

agcaagcgcg gcgatatcct caggatgctg tcggtgtacc tctaccagat cggcattgtc     1680

aacaatctga ggagggacga gcatgctggc gtgtgggagc tcatcatttc tgatctggag     1740

aagttccgcg agaagatcta cccttacctc aggattaaga agtcacagtt cgacaaggtc     1800

tactctattt caaagaacga gggcgatttc ctcccggttg cgtctatctt ccggaagctg     1860

aagttccgcg acggcttcaa gaatcggatc ctcgacgagg agattccacg cgatgaggtg     1920

gcgaaggtcc tggagtacgc tgaggactca cctgagaagg agttcctcaa ctccctggtt     1980

gaggccaggg tgacatgggt tcgggtggag aagatcgagg agaggcatta cactggcaag     2040

ctctacgact tcacaactac tacagagaac ttcatttcca atggcatcgt ctcacacaac     2100

tcaacatatg ccagcttaaa cggtacatcg atggctactc ctcatgttgc aggtgcggcc     2160

gcccttgtta aacaaaagaa cccatcttgg tctaatgtac aaattcgaaa tcatctaaag     2220

aatacggcaa ctagtttagg aagcacgaac ttgtatggaa gcggacttgt taacgcagaa     2280

gcggcaacgc gt                                                         2292


<210>  579
<211>  2430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Pno_RPA2

<400>  579
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctctctg cggatcatga ggttctcaca      900

tctacagggt ggaaggctct ccccgctatt aaggatgcgg atcaggttat gacgctggac      960

ctccagacgg gcacacagca gtggaactcg gtgcaggcta ccacgaggtt cgcgcgggag     1020

ggctcactct acaggctgaa gtccgacgat atggatgcgg tctgcaacga gtctcaccgc     1080

tggtacctca atactaagga ccagccaaca acttacaccg ctttcaccac gcagcagatg     1140

ctggataacc agctcgtggc tctgcgcaac tcctccggca aggctacgga ccagtggaac     1200

cacgagtccg ggacaactac ccacacgaac cataatatcc ctacagtcgg ccataacggg     1260

aatgttatgt tcagctggcc agactgccca tggctcccac gcgagttcgt cgctgatgag     1320

gcgtgcaacc tcgactggtg caggttcatc ggcctcgtga tgggcgacgg gtcgattgat     1380

catgtcacgg acgctcaggg ccaggagcac tacagcatcc agattcatca gagggctggg     1440

aacccagctt cgaacgctaa tacagaggat gtcctggaga ggctggctgc taagctgcca     1500

aatttcgtgg tccacccatc ctgcgttagc ggcgcggagg agaagcatac ttggaccatc     1560

aaccaccggg acatgtacca tttcttcctc cccatgatgc gcggcccaca gtcctacgac     1620

cctctggata acgccatgtg caggacctac caggctccag attaccaggc cctctcgcgg     1680

tctgacaatg agcctatcat tccagtgcca gctgactgga agaccggcaa ctggtggcac     1740

ctgcgcaggt ggatcaatta cccatggctc ttctcgctgg cccagtctca ggcgagggct     1800

atgattaagg gcatggctgc cgcgaacggg gattggtcac tctccctgaa ggctaggctg     1860

gacaccggcg attctggggt tgtgagggtt ttcagcaatt cgatccccct catgcacgac     1920

atgtcagtgc tgggcctcct ggccgatact cgcgtgaaca ttggcgtcga ccataagaag     1980

gggcagatgc agctccaggt ccctgttacc atgccggcgc tcctggcttg gtgcatctct     2040

ttctcattcg cgaactccga cctggctgtg gctgctccaa agcctgaggc gtacgataat     2100

ccgaggcacg acggcttcgt ttactgcctc acggtgccca acgggaattt cctggcccgg     2160

cgcacagtcg agtacagcga taatgataag attcaggagg tcattgatgc tgctcagaag     2220

cctttcttca caggcaactc aacatatgcc agcttaaacg gtacatcgat ggctactcct     2280

catgttgcag gtgcggccgc ccttgttaaa caaaagaacc catcttggtc taatgtacaa     2340

attcgaaatc atctaaagaa tacggcaact agtttaggaa gcacgaactt gtatggaagc     2400

ggacttgtta acgcagaagc ggcaacgcgt                                      2430


<210>  580
<211>  2106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:SaP-SETP3_Helicase

<400>  580
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctcaagc gggggacaga ggtcattatg      900

ttcgatggga caactaagaa ggtggaggac gttatcgtgg gggacgttct catggggcca      960

gacagcaccc ctaggaacgt gctctcgctg ggcaggggga gggagatgat gtacgaggtg     1020

aagccacgga agggcgagtc ctacacggtc aatgagtcac acatcctctc cctgcgcacc     1080

acgacaggca ttgcgaaggg gtcctggcct gacaacacag tcttcgatat cagcgttcgg     1140

gactggctca agctgccaaa gtatgtgact ggccctaatg ggtacctcaa gggctggagg     1200

gtgccagtcg atttcccaag gaaggagcag gacgaggctc tcctgccacc atacctgatg     1260

ggcctctggc tgggcgacgg gacttccagc tcgggcgcta tcacctcggg ggagaatgag     1320

aaggagatta gggcttacct ggagtcttac gctgctagga acggcatgca gatcaggaag     1380

gaggggctga cttggtctat ttcacacggc aacaccgggc acaagaagca tggcttcacg     1440

catgcgctca agagcgctgg ggtgctgaac aataagcaca tcccgcataa ctacaagtgc     1500

ggcgatagga ggcagaggct ggagctcctg gctggcctcc tggactctga tgggtactgc     1560

gatctctcaa aggctggctt cgactggatt tccgttagcg agaggctggc cgacgatttc     1620

tgctacctct gccggtcgct gggcttcgct gcctacaaga agaagacctg caagcgctgc     1680

gcgaacacag acgtctgggg cgattacttc agggtttcgg tgtctgggga cttctccgag     1740

gtgccattcg tcaggggcag gcatcagaat ctccccaagc gcaacatcaa taagaacgtt     1800

ctgaacgtgg gcatcgagtc cattaccccc gtcggcgttg acgattactt cgggttcaca     1860

attgatgggg attcaaggtt cctcctcggg gatttcacag ttactcataa tacctcaaca     1920

tatgccagct taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt     1980

gttaaacaaa agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg     2040

gcaactagtt taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca     2100

acgcgt                                                                2106


<210>  581
<211>  2322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:StP-Twort_ORF6

<400>  581
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcatttcta tggactctat gattctgaca      900

actgagggct acaagtcgct gcaggagatt ttcgagacac agggggttaa ggtggacaac      960

aaggagaagg ttatcgagct gaagtacccg ctcattaatc ggtacggcga cgtggagtac     1020

acctcccact tcacgaagaa cggggagaag ccaacaaagc gcatcaagac taataagggc     1080

attgagctgg ttaacacata caatcatcct ctcctggtga gggaggggtt caacctgatc     1140

tggaagaaga gcgaggacat cgaagtgggc gatattctcg tgtcccgcgt gggcgaccac     1200

cagttcggga acaataacac tgtggagaac gaggaggagg cttacgctct gggctgcatg     1260

gtcgcggatt cttacctggg gtcatactcc cggctcagct tctcgaacga caagaaggag     1320

atcctcgata aggtctcaaa gttctggaac accttctcca ataaggaggt ttactacgac     1380

acctacaagg agtccaaggg gatcacgatt cacctgcatg acacaaacaa gactaaggag     1440

ttccatgata agtacaagat cgagtacggc gtcgctaagg acaagaagat cccgaagtgc     1500

attatggaga gccccgagaa catccagctg gccttcgtct cgggctacct ggagtgcgag     1560

tccagcatct ctgagaagaa cctggaggtt acctctgctt caaaggacct cctgaaggat     1620

ctccagctga tcctctcgaa catcggcatt gtgtctacga ataaggagaa ggtggtcaag     1680

aagtacaagc acaacaagta ctaccggctg atcgtcaatc gcaaggagct cattaagctc     1740

ctgccgctcc tgaggttcga gacgcagcag cggaagaacc agaaggagaa tttcctcagc     1800

aataacacaa agatcaagtc gtcttacggc aacactattg aggggtcacg ctacctcctg     1860

aagaagtaca gggactccct gaatatcgat aagaaggagt tctccaagta cctcagccgg     1920

gacaccatca cgattgatcg cctgagggag gtcatctcgc tctacccgga cggcgataag     1980

gagattcgcg agctgttcga gaacgttgtg aataacaata tctactacca gaaggtggag     2040

caggtcctgg agggcgagat cattcccacc ttcgacgttt gcatgcctaa gactcattcc     2100

ttcatcgcca acacaatcgt caaccacaac tcaacatatg ccagcttaaa cggtacatcg     2160

atggctactc ctcatgttgc aggtgcggcc gcccttgtta aacaaaagaa cccatcttgg     2220

tctaatgtac aaattcgaaa tcatctaaag aatacggcaa ctagtttagg aagcacgaac     2280

ttgtatggaa gcggacttgt taacgcagaa gcggcaacgc gt                        2322


<210>  582
<211>  2346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ter_DnaE-2

<400>  582
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctctcgg ggtctacaaa ggtcattgac      900

gctgctacgg ggaatctctt ctcgctcaag gagatcgccg ctcagcctga gtactggctc      960

tcgcgcaagg tcttctctct cgacctgaag tcacagcagg tggtccagca gccaatcacc     1020

gagattcacc ctaatggcgt gagggatgtc tggcagatca ccacgaggac caacaggaag     1080

gtgtgcgcta cggacgatca tctcttctac acagtcctgg gctggaagcc gctcaaggac     1140

ttcagcgttg gcgatcgcct cgggctgccg aataagatcc ccattaacta caggtcccag     1200

atctccgaca gcaaggtgaa gttcacggcg tacctcattg gcgaggggta cctgtacaca     1260

aattcgttct cttgctcata cttctgcaac tccgacgggg agctcatcgc ggatttctac     1320

ggctgcgctg aggagctgtt cgggtccagc gctccaatcg agaagcagct ccacctgggc     1380

aataagtccg tgatctacgt gcggatcggc ctcatttccg ggctgaagaa ctgggtcgac     1440

tcctacctcc agtgcgcgaa tagccgcgtg caggagatcc ccaactggat tttctccctc     1500

agccagtcgc agctccagct gttcctcggc atcctgtggt ctacgtcagg gatcttcgac     1560

gagacaattg gctacactta ctactcgtct aacagcgagg tcctggttag gcaggtccag     1620

catctgttcc tccggctggg catcgtttcc ctcttcaacg tcaataaggt taagggccag     1680

ggggagctgg acgtgtccta cgttgtggag gtccgcggga gggaggatat gctgaagttc     1740

tacaagctca tcaagccgta cctgtcatcc tacaagcagg gcctctgcga gagctgctac     1800

ctggtcatta agtaccagca gtcgtaccag ttcaagtact tcctcactcc cgacttcttc     1860

gatctgatcg tgaaggctaa gaaggccagc tcgatgacca gggctctcgg cgtttgcggc     1920

ggggagatct cttcagtgtg gaacttccag aatacatcta accggtccct gagcttcgac     1980

aagttcaaca atttctcgac tgtcctcgcg gatgaggagc tgaccgccat cgcgaactcg     2040

gacgtgttct gggatgagat catttctatc gagtacattg gcaaggagga ggtgttcgat     2100

ctcactattc cagagactca taacttcatt gctaatgact tcatcgtgca taattcaaca     2160

tatgccagct taaacggtac atcgatggct actcctcatg ttgcaggtgc ggccgccctt     2220

gttaaacaaa agaacccatc ttggtctaat gtacaaattc gaaatcatct aaagaatacg     2280

gcaactagtt taggaagcac gaacttgtat ggaagcggac ttgttaacgc agaagcggca     2340

acgcgt                                                                2346


<210>  583
<211>  2031
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Ter_RIR1-3

<400>  583
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcgtttcgg gggatacgct gctgattaca      900

agggactcta ttcataagat taaggatgtc gtggggcaga agattgagat ttggaatggc      960

aagaactggt ctcaggtcat cccgctgaag acagggaagg acaggaagct ctaccgggtt     1020

cgcttcggcg acgggtcgta cctggatgtt accgagtacc accgcttctt cgtgaaggac     1080

aggttcggca agaagtacga ggaggtgcag accaaggatc tcctgacgca ctccaagtac     1140

gccctggacg tcgagccatt catcattgat taccatgacg gcgattcgat caacctctct     1200

tacgcttaca cactgggggc tgctctcggc aatgggacta tcgaccagaa ctctaatggc     1260

aagattaggg tgtactcaca taaggccgag ctgatcttcg cgggcaacaa gtccctggag     1320

cggcagtaca attacctccc gagcttcgtg gacgtcattg atctcggctt ctcgggggag     1380

ctcctgagga ggctgcagac cgagcccgac gctctcaaca cgatcgcctc atggaataag     1440

tccgctatcc tggccttcat tgcgggcctc gctgacacag atgggagcga gactaagggc     1500

aacgggatca agatttccgt gagcgactac gagagggcca agcggctgca gctcctgctc     1560

acgaagtgcg gcattagggc gagcgtcaat ctgatggctt cgcggggctg caccacgaac     1620

ctcggggagc gcaatcagga cctgtactac ctccagatca ccgattgccg ggagattcca     1680

tgccagcgcc tcgacacaac taaggtttgc gaggcgaagt tccagggcaa gtaccagacc     1740

atccagaacg tcgaggagct gcctggcctc cacgatacgt actgcttcga ggagccagag     1800

ttccacaagg gggttttcgg caatgctctc acaggcaact caacatatgc cagcttaaac     1860

ggtacatcga tggctactcc tcatgttgca ggtgcggccg cccttgttaa acaaaagaac     1920

ccatcttggt ctaatgtaca aattcgaaat catctaaaga atacggcaac tagtttagga     1980

agcacgaact tgtatggaag cggacttgtt aacgcagaag cggcaacgcg t              2031


<210>  584
<211>  2271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Tko_Helicase

<400>  584
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcatgcatc ctgacacata cgtggttact      900

aagtcggggg ctaagaaggt ctctgagctg actgaggggg atgaggtcct gacacatacc      960

ggcacgttca agaaggtcat ccagccactg aggagggagc acaaggggcg cctcctggtt     1020

atcaaggcct acggcaccgt gcctgtcaag attacgccgg agcacatggt ttgggtggtc     1080

aagcagatca ggcacaagtc ccattacagc gatgggcggc aggtcatttg gtgggagttc     1140

gagggcccag agtggatgac ggctcaggag ctgaaggagc gcctggagtc cgagacagac     1200

ccaaaggtga gctacatgct cctgcagcca atccctgagc cgtccgtgga cgcggataag     1260

attcctctga ggaaggaggt ctacgttgtg aaccagcacg gcaagacaga caagctccat     1320

ccgtccgtga agcggactcc cgagtacctg ccactcaact tcgagaccgc taggctgatc     1380

ggcctctgga ttgctgaggg gtcaacttcc aagaacggcg tcatcaagtt cgacatttcc     1440

agcaatgagg aggatctgac ggagttcatc acaggcacta ttaggaagta cttcccgcac     1500

gctaagatcg tcgttaagga ccatgagagg aacaggagga cggtccggtt ctgcaataag     1560

cgcttcgcgg agtggctcag ggagaacatc ggccacgggg ctgataataa gagcattccg     1620

cccctcctgc tcctgaacaa gaatagggag gtgcgcctgg gcctcctgag ggggctcatc     1680

gagggcgacg gctacgtgcg cagggagtcg cagcgcaggg cgaactacat cagctactcg     1740

acagtttctc cctcactggc ttaccagctc cagctcctgg tggcttcgct gggctacacc     1800

tcgtctatcc acaggtctat tcggacagag ggcatcggga agactaggaa gcccatctac     1860

gatgttaagg tgtcgggcaa gtcttactac tcactcctgg aggagctcgg gttcgaggtc     1920

ccacagaggg gcaacaggac ctacaacgtt aatcgcacgt ggaagaatta cctcctgctc     1980

aaggtgaggt ccatcgagga ggaggagtac gagggcgacg tttacaatct ggaggttgag     2040

ggggatgagt caggctctgt gggcttcatc gtgcataatt caacatatgc cagcttaaac     2100

ggtacatcga tggctactcc tcatgttgca ggtgcggccg cccttgttaa acaaaagaac     2160

ccatcttggt ctaatgtaca aattcgaaat catctaaaga atacggcaac tagtttagga     2220

agcacgaact tgtatggaag cggacttgtt aacgcagaag cggcaacgcg t              2271


<210>  585
<211>  2670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Tko_Pol-2_Pko_Pol-2

<400>  585
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tctattctgc ctgaggagtg gctgcctgtt      900

ctggaggagg gggaggttca tttcgttagg atcggggagc tgattgaccg catgatggag      960

gagaacgctg gcaaggtcaa gagggagggg gagaccgagg tcctggaggt ttcaggcctg     1020

gaggtgccgt ccttcaaccg caggacgaat aaggcggagc tgaagagggt caaggctctc     1080

atccggcacg actactctgg caaggtgtac accattaggc tgaagtcagg ccggcgcatc     1140

aagattacgt cagggcattc cctgttcagc gtccggaacg gcgagctcgt tgaggtgacc     1200

ggcgacgagc tgaagccagg ggatctcgtc gctgttccaa ggaggctgga gctgccagag     1260

aggaaccacg tcctcaatct ggttgagctc ctgctcggca caccggagga ggagactctg     1320

gacatcgtga tgacgattcc cgtcaagggc aagaagaact tcttcaaggg gatgctcagg     1380

acactgcggt ggatcttcgg cgaggagaag aggccaagga ctgctcgcag gtacctcagg     1440

catctggagg acctcggcta cgtgcggctc aagaagatcg ggtacgaggt cctggactgg     1500

gatagcctca agaattaccg gcgcctgtac gaggctctcg tggagaacgt ccgctacaac     1560

ggcaataaga gggagtacct ggttgagttc aattcgatcc gcgacgccgt ggggattatg     1620

ccgctgaagg agctcaagga gtggaagatc ggcacactca acgggttccg gatgcgcaag     1680

ctgattgagg tcgatgagtc cctcgccaag ctgctcggct actacgtgag cgaggggtac     1740

gcgcgcaagc agaggaaccc gaagaatggc tggtcgtact ctgtcaagct gtacaatgag     1800

gaccccgagg ttctggacga tatggagcgg ctcgcgagcc gcttcttcgg caaggttagg     1860

cgggggagga actacgtgga gatccccaag aagattggct acctgctctt cgagaatatg     1920

tgcggggtgc tcgctgagaa caagcgcatc ccagagttcg tcttcacatc acctaagggc     1980

gttaggctgg ccttcctgga ggggtactcc agcgctatgg ctacctccac ggagcaggag     2040

actcaggcgc tgaacgagaa gcgcgctctg gccaatcagc tcgttctgct cctgaactcg     2100

gtgggcgtct ctgctgtgaa gctcggccac gactccgggg tttacagggt gtacatcaat     2160

gaggagctgc cattcgtcaa gctcgataag aagaagaacg cttactacag ccatgtgatt     2220

cctaaggagg tcctctcgga ggtcttcggc aaggttttcc agaagaacgt gtccccacag     2280

accttccgga agatggtcga ggacggcagg ctggatcctg agaaggctca gaggctgtcg     2340

tggctcatcg agggggacgt ggtcctcgat cgcgtcgagt ctgttgacgt ggaggactac     2400

gatggctacg tgtacgatct ctctgtggag gataatgaga acttcctcgt gggcttcggg     2460

ctcgtttacg ctcataattc aacatatgcc agcttaaacg gtacatcgat ggctactcct     2520

catgttgcag gtgcggccgc ccttgttaaa caaaagaacc catcttggtc taatgtacaa     2580

attcgaaatc atctaaagaa tacggcaact agtttaggaa gcacgaactt gtatggaagc     2640

ggacttgtta acgcagaagc ggcaacgcgt                                      2670


<210>  586
<211>  1983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified proSavinase_S317:Unc-ERS_RIR1

<400>  586
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcgttaccg ctgacacatg ggttactacc      900

gctgaggggc caaggcaggt ggaggagctg atcggcaaga agttcacggc tatcgttaac      960

ggcgaggagt gggagtccag cgaggagggg ttcttcgaga cagacgttaa gccagtgtac     1020

accctgaaga cggctgaggg cttcgagctg aggctcacgg ctgatcaccc tgtcatgaag     1080

gttgagagga tgacacggta caaggtggag actcagtggt ccaacgctgg cgacctcaag     1140

ccaggggata agatcattat caacaatcat agggacttcg gcaattggag cgtcaagggg     1200

aagtacaccg agggcgaggg gtacctgatt ggcctcctgc tcggcgacgg gacgatcaag     1260

aagctcaacc cctggatgaa ggcgatttca aagaagatgg agaaggcctc cgcggatttc     1320

tgcgagggca tcctgagggg gctcttcgac gctgatggct ctgtgcaggg gaatcagtcg     1380

aagggcgtct ctattcgcct ggcccagtca gacgtcgaga tcctcaaggc ggttcagcgc     1440

attctgctca ggttcggcat cttctcgaag gtgtacatga accgcagggg cgagcggaag     1500

gttaagatgc cggatgggaa gggcggggtc aaggagtaca tcaccaagcc ccagcacgag     1560

ctcgtgatca gcaacgacaa tatcctctac ttcgctgaga gggtcggctt ctcggatgcc     1620

gagaagatgg agaagctgga gaaggctatc tggaactaca agcggaagat gaatagggag     1680

aggttcgtgg ctagcgtcga ggaggtggtc ccagacggcg ttgagaaggt gtacgacgtt     1740

aagattccag gcatcaatgc tttcaatgct aatggcttcg tggttcacaa ctcaacatat     1800

gccagcttaa acggtacatc gatggctact cctcatgttg caggtgcggc cgcccttgtt     1860

aaacaaaaga acccatcttg gtctaatgta caaattcgaa atcatctaaa gaatacggca     1920

actagtttag gaagcacgaa cttgtatgga agcggacttg ttaacgcaga agcggcaacg     1980

cgt                                                                   1983


<210>  587
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct NI-GG-6H

<400>  587
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgtctggacc tgaaaacgca agtgcaaacc      900

ccgcaaggca tgaaggaaat ctcaaacatc caagtcggtg acctggtgct gtcgaatacc      960

ggctataacg aagtgctgaa tgtttttccg aagagcaaaa agaaatctta caagatcacg     1020

ctggaagatg gcaaggaaat tatttgcagc gaagaacatc tgttcccgac ccagacgggc     1080

gaaatgaata tctccggcgg tctgaaagaa ggcatgtgtc tgtacgtcaa ggaaggtggc     1140

catcaccatc atcaccac                                                   1158


<210>  588
<211>  624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct IC-SUMO-6H

<400>  588
atgatgctga agaaaattct gaagatcgaa gaactggatg aacgtgaact gattgacatc       60

gaagttagcg gcaaccatct gttttacgcg aatgacattc tgacccacaa ctcaacttat      120

gccagcttaa acggtacatc gatggctact cctcatgttg caggtgcggc cgcccttgtt      180

aaacaaaaga acccatcttg gtctaatgta caaattcgaa atcatctaaa gaatacggca      240

actagtttag gaagcacgaa cttgtatgga agcggacttg ttaacgcaga agcggcaacg      300

cgtatggggt ccctgcagga ctcagaagtc aatcaagaag ctaagccaga ggtcaagcca      360

gaagtcaagc ctgagactca catcaattta aaggtgtccg atggatcttc agagatcttc      420

ttcaagatca aaaagaccac tcctttaaga aggctgatgg aagcgttcgc taaaagacag      480

ggtaaggaaa tggactcctt aacgttcttg tacgacggta ttgaaattca agctgatcag      540

acccctgaag atttggacat ggaggataac gatattattg aggctcaccg cgaacagatt      600

ggaggtcatc accaccatca tcac                                             624


<210>  589
<211>  627
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_IMPDH-NI

<400>  589
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgcttt gtcccgggca cgctggtgaa taccgaaaat      360

ggtctgaaaa agattgaaga aattaaagtg ggcgataagg tgtttagtca taccggcaaa      420

ctgcaagaag tggttgatac gctgattttt gatcgtgacg aagaaattat cagtattaac      480

ggtatcgact gcaccaagaa ccatgaattt tacgtgatcg ataaggaaaa cgcgaatcgt      540

gttaacgaag acaatatcca tctgttcgcg cgctgggtcc acgccgaaga actggatatg      600

aaaaagcacc tgctgatcga actggaa                                          627


<210>  590
<211>  1029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_IMPDH-NI

<400>  590
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctgct ttgtcccggg cacgctggtg aataccgaaa atggtctgaa aaagattgaa      780

gaaattaaag tgggcgataa ggtgtttagt cataccggca aactgcaaga agtggttgat      840

acgctgattt ttgatcgtga cgaagaaatt atcagtatta acggtatcga ctgcaccaag      900

aaccatgaat tttacgtgat cgataaggaa aacgcgaatc gtgttaacga agacaatatc      960

catctgttcg cgcgctgggt ccacgccgaa gaactggata tgaaaaagca cctgctgatc     1020

gaactggaa                                                             1029


<210>  591
<211>  1101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_IMPDH-NI

<400>  591
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgcttg ctttgtcccg ggcacgctgg tgaataccga aaatggtctg      840

aaaaagattg aagaaattaa agtgggcgat aaggtgttta gtcataccgg caaactgcaa      900

gaagtggttg atacgctgat ttttgatcgt gacgaagaaa ttatcagtat taacggtatc      960

gactgcacca agaaccatga attttacgtg atcgataagg aaaacgcgaa tcgtgttaac     1020

gaagacaata tccatctgtt cgcgcgctgg gtccacgccg aagaactgga tatgaaaaag     1080

cacctgctga tcgaactgga a                                               1101


<210>  592
<211>  1173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_IMPDH-NI

<400>  592
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgctttgtcc cgggcacgct ggtgaatacc      900

gaaaatggtc tgaaaaagat tgaagaaatt aaagtgggcg ataaggtgtt tagtcatacc      960

ggcaaactgc aagaagtggt tgatacgctg atttttgatc gtgacgaaga aattatcagt     1020

attaacggta tcgactgcac caagaaccat gaattttacg tgatcgataa ggaaaacgcg     1080

aatcgtgtta acgaagacaa tatccatctg ttcgcgcgct gggtccacgc cgaagaactg     1140

gatatgaaaa agcacctgct gatcgaactg gaa                                  1173


<210>  593
<211>  1176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_IMPDH-NI

<400>  593
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tcatgctttg tcccgggcac gctggtgaat      900

accgaaaatg gtctgaaaaa gattgaagaa attaaagtgg gcgataaggt gtttagtcat      960

accggcaaac tgcaagaagt ggttgatacg ctgatttttg atcgtgacga agaaattatc     1020

agtattaacg gtatcgactg caccaagaac catgaatttt acgtgatcga taaggaaaac     1080

gcgaatcgtg ttaacgaaga caatatccat ctgttcgcgc gctgggtcca cgccgaagaa     1140

ctggatatga aaaagcacct gctgatcgaa ctggaa                               1176


<210>  594
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_gp41-1-NI

<400>  594
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgtctg gacctgaaaa cgcaagtgca aaccccgcaa      360

ggcatgaagg aaatctcaaa catccaagtc ggtgacctgg tgctgtcgaa taccggctat      420

aacgaagtgc tgaatgtttt tccgaagagc aaaaagaaat cttacaagat cacgctggaa      480

gatggcaagg aaattatttg cagcgaagaa catctgttcc cgacccagac gggcgaaatg      540

aatatctccg gcggtctgaa agaaggcatg tgtctgtacg tcaaggaa                   588


<210>  595
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_gp41-1-NI

<400>  595
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctgtc tggacctgaa aacgcaagtg caaaccccgc aaggcatgaa ggaaatctca      780

aacatccaag tcggtgacct ggtgctgtcg aataccggct ataacgaagt gctgaatgtt      840

tttccgaaga gcaaaaagaa atcttacaag atcacgctgg aagatggcaa ggaaattatt      900

tgcagcgaag aacatctgtt cccgacccag acgggcgaaa tgaatatctc cggcggtctg      960

aaagaaggca tgtgtctgta cgtcaaggaa                                       990


<210>  596
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_gp41-1-NI

<400>  596
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgcttg tctggacctg aaaacgcaag tgcaaacccc gcaaggcatg      840

aaggaaatct caaacatcca agtcggtgac ctggtgctgt cgaataccgg ctataacgaa      900

gtgctgaatg tttttccgaa gagcaaaaag aaatcttaca agatcacgct ggaagatggc      960

aaggaaatta tttgcagcga agaacatctg ttcccgaccc agacgggcga aatgaatatc     1020

tccggcggtc tgaaagaagg catgtgtctg tacgtcaagg aa                        1062


<210>  597
<211>  1134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_gp41-1-NI

<400>  597
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgtctggacc tgaaaacgca agtgcaaacc      900

ccgcaaggca tgaaggaaat ctcaaacatc caagtcggtg acctggtgct gtcgaatacc      960

ggctataacg aagtgctgaa tgtttttccg aagagcaaaa agaaatctta caagatcacg     1020

ctggaagatg gcaaggaaat tatttgcagc gaagaacatc tgttcccgac ccagacgggc     1080

gaaatgaata tctccggcgg tctgaaagaa ggcatgtgtc tgtacgtcaa ggaa           1134


<210>  598
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_gp41-1-NI

<400>  598
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tcatgtctgg acctgaaaac gcaagtgcaa      900

accccgcaag gcatgaagga aatctcaaac atccaagtcg gtgacctggt gctgtcgaat      960

accggctata acgaagtgct gaatgttttt ccgaagagca aaaagaaatc ttacaagatc     1020

acgctggaag atggcaagga aattatttgc agcgaagaac atctgttccc gacccagacg     1080

ggcgaaatga atatctccgg cggtctgaaa gaaggcatgt gtctgtacgt caaggaa        1137


<210>  599
<211>  597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_gp41-8-NI

<400>  599
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgtctg tccctggata cgatggttgt gacgaatggc      360

aaggctattg aaatccgtga tgtgaaagtg ggcgactggc tggaaagcga actgggcccg      420

gtgcaggtta ccgaagtcct gccgattatc aaacaaccgg tttttgaaat tgtcctgaaa      480

agcaagtctg gcaaaaagat ccgtgtgagc gcaaaccata aattcccgac caaggatggt      540

ctgaaaacga ttaatagtgg cctgaaggtt ggtgactttc tgcgttcccg cgcgaaa         597


<210>  600
<211>  999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_gp41-8-NI

<400>  600
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctgtc tgtccctgga tacgatggtt gtgacgaatg gcaaggctat tgaaatccgt      780

gatgtgaaag tgggcgactg gctggaaagc gaactgggcc cggtgcaggt taccgaagtc      840

ctgccgatta tcaaacaacc ggtttttgaa attgtcctga aaagcaagtc tggcaaaaag      900

atccgtgtga gcgcaaacca taaattcccg accaaggatg gtctgaaaac gattaatagt      960

ggcctgaagg ttggtgactt tctgcgttcc cgcgcgaaa                             999


<210>  601
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_gp41-8-NI

<400>  601
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgcttg tctgtccctg gatacgatgg ttgtgacgaa tggcaaggct      840

attgaaatcc gtgatgtgaa agtgggcgac tggctggaaa gcgaactggg cccggtgcag      900

gttaccgaag tcctgccgat tatcaaacaa ccggtttttg aaattgtcct gaaaagcaag      960

tctggcaaaa agatccgtgt gagcgcaaac cataaattcc cgaccaagga tggtctgaaa     1020

acgattaata gtggcctgaa ggttggtgac tttctgcgtt cccgcgcgaa a              1071


<210>  602
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_gp41-8-NI

<400>  602
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgtctgtccc tggatacgat ggttgtgacg      900

aatggcaagg ctattgaaat ccgtgatgtg aaagtgggcg actggctgga aagcgaactg      960

ggcccggtgc aggttaccga agtcctgccg attatcaaac aaccggtttt tgaaattgtc     1020

ctgaaaagca agtctggcaa aaagatccgt gtgagcgcaa accataaatt cccgaccaag     1080

gatggtctga aaacgattaa tagtggcctg aaggttggtg actttctgcg ttcccgcgcg     1140

aaa                                                                   1143


<210>  603
<211>  1146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_gp41-8-NI

<400>  603
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tcatgtctgt ccctggatac gatggttgtg      900

acgaatggca aggctattga aatccgtgat gtgaaagtgg gcgactggct ggaaagcgaa      960

ctgggcccgg tgcaggttac cgaagtcctg ccgattatca aacaaccggt ttttgaaatt     1020

gtcctgaaaa gcaagtctgg caaaaagatc cgtgtgagcg caaaccataa attcccgacc     1080

aaggatggtc tgaaaacgat taatagtggc ctgaaggttg gtgactttct gcgttcccgc     1140

gcgaaa                                                                1146


<210>  604
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_NrdJ-1-NI

<400>  604
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgcctg gtcggtagca gcgaaatcat cacgcgcaac      360

tatggtaaaa cgacgatcaa ggaagtggtg gaaatctttg acaacgataa aaacattcag      420

gtcctggcgt ttaacaccca tacggataat attgaatggg ccccgatcaa agcggcccaa      480

ctgacccgtc cgaatgcaga actggttgaa ctggaaattg acacgctgca tggcgtcaaa      540

accatccgct gcacgccgga tcacccggtc tataccaaga accgtggtta cgtgcgcgct      600

gacgaactga cggatgacga tgaactggtg gttgcaatt                             639


<210>  605
<211>  1041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_NrdJ-1-NI

<400>  605
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctgcc tggtcggtag cagcgaaatc atcacgcgca actatggtaa aacgacgatc      780

aaggaagtgg tggaaatctt tgacaacgat aaaaacattc aggtcctggc gtttaacacc      840

catacggata atattgaatg ggccccgatc aaagcggccc aactgacccg tccgaatgca      900

gaactggttg aactggaaat tgacacgctg catggcgtca aaaccatccg ctgcacgccg      960

gatcacccgg tctataccaa gaaccgtggt tacgtgcgcg ctgacgaact gacggatgac     1020

gatgaactgg tggttgcaat t                                               1041


<210>  606
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_NrdJ-1-NI

<400>  606
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgcttg cctggtcggt agcagcgaaa tcatcacgcg caactatggt      840

aaaacgacga tcaaggaagt ggtggaaatc tttgacaacg ataaaaacat tcaggtcctg      900

gcgtttaaca cccatacgga taatattgaa tgggccccga tcaaagcggc ccaactgacc      960

cgtccgaatg cagaactggt tgaactggaa attgacacgc tgcatggcgt caaaaccatc     1020

cgctgcacgc cggatcaccc ggtctatacc aagaaccgtg gttacgtgcg cgctgacgaa     1080

ctgacggatg acgatgaact ggtggttgca att                                  1113


<210>  607
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_NrdJ-1-NI

<400>  607
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctggtcg gtagcagcga aatcatcacg      900

cgcaactatg gtaaaacgac gatcaaggaa gtggtggaaa tctttgacaa cgataaaaac      960

attcaggtcc tggcgtttaa cacccatacg gataatattg aatgggcccc gatcaaagcg     1020

gcccaactga cccgtccgaa tgcagaactg gttgaactgg aaattgacac gctgcatggc     1080

gtcaaaacca tccgctgcac gccggatcac ccggtctata ccaagaaccg tggttacgtg     1140

cgcgctgacg aactgacgga tgacgatgaa ctggtggttg caatt                     1185


<210>  608
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_NrdJ-1-NI

<400>  608
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tcatgcctgg tcggtagcag cgaaatcatc      900

acgcgcaact atggtaaaac gacgatcaag gaagtggtgg aaatctttga caacgataaa      960

aacattcagg tcctggcgtt taacacccat acggataata ttgaatgggc cccgatcaaa     1020

gcggcccaac tgacccgtcc gaatgcagaa ctggttgaac tggaaattga cacgctgcat     1080

ggcgtcaaaa ccatccgctg cacgccggat cacccggtct ataccaagaa ccgtggttac     1140

gtgcgcgctg acgaactgac ggatgacgat gaactggtgg ttgcaatt                  1188


<210>  609
<211>  858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_IMPDH-IC

<400>  609
atgaagttca agctgaagga aatcaccagc atcgaaacga aacattataa gggcaaagtt       60

cacgatctga ccgtcaacca agaccattct tacaatgttc gcggtacggt cgtgcacaac      120

tctggtgtaa aagttgctgt cctcgataca gggatatcca ctcatccaga tctaaatatt      180

cgtggtggcg caagctttgt accaggggaa ccgtcgactc aagatgggaa tgggcatggc      240

acgcatgtgg ccgggacgat cgctgcttta aacaattcga ttggcgttct tggcgtagcg      300

ccgagcgctg agctatacgc tgttaaagtc ctaggggcga gcggttcagg ttcggtcagc      360

tcgattgccc aaggattgga atgggcaggg aacaatggca tgcacgttgc taatttgagt      420

ttaggaagcc cttcgccaag tgccacactt gagcaagctg ttaatagcgc gacttctaga      480

ggcgttcttg ttgtagcggc atctgggaac tcaggtgcag gctcaatcag ctatccggcg      540

cgctatgcga acgcaatggc agtcggagct actgatcaaa acaacaaccg cgctagcttt      600

tcacagtatg gcgcaggcct tgacattgtc gcacccgggg taaacgtgca gagcacatac      660

ccaggttcaa cttatgccag cttaaacggt acatcgatgg ctactcctca tgttgcaggt      720

gcggccgccc ttgttaaaca aaagaaccca tcttggtcta atgtacaaat tcgaaatcat      780

ctaaagaata cggcaactag tttaggaagc acgaacttgt atggaagcgg acttgttaac      840

gcagaagcgg caacgcgt                                                    858


<210>  610
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_IMPDH-IC

<400>  610
atgaagttca agctgaagga aatcaccagc atcgaaacga aacattataa gggcaaagtt       60

cacgatctga ccgtcaacca agaccattct tacaatgttc gcggtacggt cgtgcacaac      120

tcaatcagct atccggcgcg ctatgcgaac gcaatggcag tcggagctac tgatcaaaac      180

aacaaccgcg ctagcttttc acagtatggc gcaggccttg acattgtcgc acccggggta      240

aacgtgcaga gcacataccc aggttcaact tatgccagct taaacggtac atcgatggct      300

actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa agaacccatc ttggtctaat      360

gtacaaattc gaaatcatct aaagaatacg gcaactagtt taggaagcac gaacttgtat      420

ggaagcggac ttgttaacgc agaagcggca acgcgt                                456


<210>  611
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_IMPDH-IC

<400>  611
atgaagttca agctgaagga aatcaccagc atcgaaacga aacattataa gggcaaagtt       60

cacgatctga ccgtcaacca agaccattct tacaatgttc gcggtacggt cgtgcacaac      120

agcttttcac agtatggcgc aggccttgac attgtcgcac ccggggtaaa cgtgcagagc      180

acatacccag gttcaactta tgccagctta aacggtacat cgatggctac tcctcatgtt      240

gcaggtgcgg ccgcccttgt taaacaaaag aacccatctt ggtctaatgt acaaattcga      300

aatcatctaa agaatacggc aactagttta ggaagcacga acttgtatgg aagcggactt      360

gttaacgcag aagcggcaac gcgt                                             384


<210>  612
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_IMPDH-IC

<400>  612
atgaagttca agctgaagga aatcaccagc atcgaaacga aacattataa gggcaaagtt       60

cacgatctga ccgtcaacca agaccattct tacaatgttc gcggtacggt cgtgcacaac      120

tcaacttatg ccagcttaaa cggtacatcg atggctactc ctcatgttgc aggtgcggcc      180

gcccttgtta aacaaaagaa cccatcttgg tctaatgtac aaattcgaaa tcatctaaag      240

aatacggcaa ctagtttagg aagcacgaac ttgtatggaa gcggacttgt taacgcagaa      300

gcggcaacgc gt                                                          312


<210>  613
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_IMPDH-IC

<400>  613
atgaagttca agctgaagga aatcaccagc atcgaaacga aacattataa gggcaaagtt       60

cacgatctga ccgtcaacca agaccattct tacaatgttc gcggtacggt cgtgcacaac      120

acttatgcca gcttaaacgg tacatcgatg gctactcctc atgttgcagg tgcggccgcc      180

cttgttaaac aaaagaaccc atcttggtct aatgtacaaa ttcgaaatca tctaaagaat      240

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg      300

gcaacgcgt                                                              309


<210>  614
<211>  849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_gp41-1-IC

<400>  614
atgatgctga agaaaattct gaagatcgaa gaactggatg aacgtgaact gattgacatc       60

gaagttagcg gcaaccatct gttttacgcg aatgacattc tgacccacaa ctctggtgta      120

aaagttgctg tcctcgatac agggatatcc actcatccag atctaaatat tcgtggtggc      180

gcaagctttg taccagggga accgtcgact caagatggga atgggcatgg cacgcatgtg      240

gccgggacga tcgctgcttt aaacaattcg attggcgttc ttggcgtagc gccgagcgct      300

gagctatacg ctgttaaagt cctaggggcg agcggttcag gttcggtcag ctcgattgcc      360

caaggattgg aatgggcagg gaacaatggc atgcacgttg ctaatttgag tttaggaagc      420

ccttcgccaa gtgccacact tgagcaagct gttaatagcg cgacttctag aggcgttctt      480

gttgtagcgg catctgggaa ctcaggtgca ggctcaatca gctatccggc gcgctatgcg      540

aacgcaatgg cagtcggagc tactgatcaa aacaacaacc gcgctagctt ttcacagtat      600

ggcgcaggcc ttgacattgt cgcacccggg gtaaacgtgc agagcacata cccaggttca      660

acttatgcca gcttaaacgg tacatcgatg gctactcctc atgttgcagg tgcggccgcc      720

cttgttaaac aaaagaaccc atcttggtct aatgtacaaa ttcgaaatca tctaaagaat      780

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg      840

gcaacgcgt                                                              849


<210>  615
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_gp41-1-IC

<400>  615
atgatgctga agaaaattct gaagatcgaa gaactggatg aacgtgaact gattgacatc       60

gaagttagcg gcaaccatct gttttacgcg aatgacattc tgacccacaa ctcaatcagc      120

tatccggcgc gctatgcgaa cgcaatggca gtcggagcta ctgatcaaaa caacaaccgc      180

gctagctttt cacagtatgg cgcaggcctt gacattgtcg cacccggggt aaacgtgcag      240

agcacatacc caggttcaac ttatgccagc ttaaacggta catcgatggc tactcctcat      300

gttgcaggtg cggccgccct tgttaaacaa aagaacccat cttggtctaa tgtacaaatt      360

cgaaatcatc taaagaatac ggcaactagt ttaggaagca cgaacttgta tggaagcgga      420

cttgttaacg cagaagcggc aacgcgt                                          447


<210>  616
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_gp41-1-IC

<400>  616
atgatgctga agaaaattct gaagatcgaa gaactggatg aacgtgaact gattgacatc       60

gaagttagcg gcaaccatct gttttacgcg aatgacattc tgacccacaa cagcttttca      120

cagtatggcg caggccttga cattgtcgca cccggggtaa acgtgcagag cacataccca      180

ggttcaactt atgccagctt aaacggtaca tcgatggcta ctcctcatgt tgcaggtgcg      240

gccgcccttg ttaaacaaaa gaacccatct tggtctaatg tacaaattcg aaatcatcta      300

aagaatacgg caactagttt aggaagcacg aacttgtatg gaagcggact tgttaacgca      360

gaagcggcaa cgcgt                                                       375


<210>  617
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_gp41-1-IC

<400>  617
atgatgctga agaaaattct gaagatcgaa gaactggatg aacgtgaact gattgacatc       60

gaagttagcg gcaaccatct gttttacgcg aatgacattc tgacccacaa ctcaacttat      120

gccagcttaa acggtacatc gatggctact cctcatgttg caggtgcggc cgcccttgtt      180

aaacaaaaga acccatcttg gtctaatgta caaattcgaa atcatctaaa gaatacggca      240

actagtttag gaagcacgaa cttgtatgga agcggacttg ttaacgcaga agcggcaacg      300

cgt                                                                    303


<210>  618
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_gp41-1-IC

<400>  618
atgatgctga agaaaattct gaagatcgaa gaactggatg aacgtgaact gattgacatc       60

gaagttagcg gcaaccatct gttttacgcg aatgacattc tgacccacaa cacttatgcc      120

agcttaaacg gtacatcgat ggctactcct catgttgcag gtgcggccgc ccttgttaaa      180

caaaagaacc catcttggtc taatgtacaa attcgaaatc atctaaagaa tacggcaact      240

agtttaggaa gcacgaactt gtatggaagc ggacttgtta acgcagaagc ggcaacgcgt      300


<210>  619
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_gp41-8-IC

<400>  619
atgtgcgaaa ttttcgaaaa cgaaatcgat tgggacgaaa ttgccagcat cgaatatgtc       60

ggcgtggaag aaaccattga tatcaacgtt acgaatgacc gcctgttttt cgcgaacggt      120

atcctgacgc acaattctgg tgtaaaagtt gctgtcctcg atacagggat atccactcat      180

ccagatctaa atattcgtgg tggcgcaagc tttgtaccag gggaaccgtc gactcaagat      240

gggaatgggc atggcacgca tgtggccggg acgatcgctg ctttaaacaa ttcgattggc      300

gttcttggcg tagcgccgag cgctgagcta tacgctgtta aagtcctagg ggcgagcggt      360

tcaggttcgg tcagctcgat tgcccaagga ttggaatggg cagggaacaa tggcatgcac      420

gttgctaatt tgagtttagg aagcccttcg ccaagtgcca cacttgagca agctgttaat      480

agcgcgactt ctagaggcgt tcttgttgta gcggcatctg ggaactcagg tgcaggctca      540

atcagctatc cggcgcgcta tgcgaacgca atggcagtcg gagctactga tcaaaacaac      600

aaccgcgcta gcttttcaca gtatggcgca ggccttgaca ttgtcgcacc cggggtaaac      660

gtgcagagca catacccagg ttcaacttat gccagcttaa acggtacatc gatggctact      720

cctcatgttg caggtgcggc cgcccttgtt aaacaaaaga acccatcttg gtctaatgta      780

caaattcgaa atcatctaaa gaatacggca actagtttag gaagcacgaa cttgtatgga      840

agcggacttg ttaacgcaga agcggcaacg cgt                                   873


<210>  620
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_gp41-8-IC

<400>  620
atgtgcgaaa ttttcgaaaa cgaaatcgat tgggacgaaa ttgccagcat cgaatatgtc       60

ggcgtggaag aaaccattga tatcaacgtt acgaatgacc gcctgttttt cgcgaacggt      120

atcctgacgc acaattcaat cagctatccg gcgcgctatg cgaacgcaat ggcagtcgga      180

gctactgatc aaaacaacaa ccgcgctagc ttttcacagt atggcgcagg ccttgacatt      240

gtcgcacccg gggtaaacgt gcagagcaca tacccaggtt caacttatgc cagcttaaac      300

ggtacatcga tggctactcc tcatgttgca ggtgcggccg cccttgttaa acaaaagaac      360

ccatcttggt ctaatgtaca aattcgaaat catctaaaga atacggcaac tagtttagga      420

agcacgaact tgtatggaag cggacttgtt aacgcagaag cggcaacgcg t               471


<210>  621
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_gp41-8-IC

<400>  621
atgtgcgaaa ttttcgaaaa cgaaatcgat tgggacgaaa ttgccagcat cgaatatgtc       60

ggcgtggaag aaaccattga tatcaacgtt acgaatgacc gcctgttttt cgcgaacggt      120

atcctgacgc acaatagctt ttcacagtat ggcgcaggcc ttgacattgt cgcacccggg      180

gtaaacgtgc agagcacata cccaggttca acttatgcca gcttaaacgg tacatcgatg      240

gctactcctc atgttgcagg tgcggccgcc cttgttaaac aaaagaaccc atcttggtct      300

aatgtacaaa ttcgaaatca tctaaagaat acggcaacta gtttaggaag cacgaacttg      360

tatggaagcg gacttgttaa cgcagaagcg gcaacgcgt                             399


<210>  622
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_gp41-8-IC

<400>  622
atgtgcgaaa ttttcgaaaa cgaaatcgat tgggacgaaa ttgccagcat cgaatatgtc       60

ggcgtggaag aaaccattga tatcaacgtt acgaatgacc gcctgttttt cgcgaacggt      120

atcctgacgc acaattcaac ttatgccagc ttaaacggta catcgatggc tactcctcat      180

gttgcaggtg cggccgccct tgttaaacaa aagaacccat cttggtctaa tgtacaaatt      240

cgaaatcatc taaagaatac ggcaactagt ttaggaagca cgaacttgta tggaagcgga      300

cttgttaacg cagaagcggc aacgcgt                                          327


<210>  623
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_gp41-8-IC

<400>  623
atgtgcgaaa ttttcgaaaa cgaaatcgat tgggacgaaa ttgccagcat cgaatatgtc       60

ggcgtggaag aaaccattga tatcaacgtt acgaatgacc gcctgttttt cgcgaacggt      120

atcctgacgc acaatactta tgccagctta aacggtacat cgatggctac tcctcatgtt      180

gcaggtgcgg ccgcccttgt taaacaaaag aacccatctt ggtctaatgt acaaattcga      240

aatcatctaa agaatacggc aactagttta ggaagcacga acttgtatgg aagcggactt      300

gttaacgcag aagcggcaac gcgt                                             324


<210>  624
<211>  858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S135_NrdJ-1-IC

<400>  624
atggaagcta aaacctatat cggcaaactg aagagccgta agattgtgtc taacgaagac       60

acctacgata tccagaccag tacgcataac tttttcgcaa atgatatcct ggttcacaat      120

tctggtgtaa aagttgctgt cctcgataca gggatatcca ctcatccaga tctaaatatt      180

cgtggtggcg caagctttgt accaggggaa ccgtcgactc aagatgggaa tgggcatggc      240

acgcatgtgg ccgggacgat cgctgcttta aacaattcga ttggcgttct tggcgtagcg      300

ccgagcgctg agctatacgc tgttaaagtc ctaggggcga gcggttcagg ttcggtcagc      360

tcgattgccc aaggattgga atgggcaggg aacaatggca tgcacgttgc taatttgagt      420

ttaggaagcc cttcgccaag tgccacactt gagcaagctg ttaatagcgc gacttctaga      480

ggcgttcttg ttgtagcggc atctgggaac tcaggtgcag gctcaatcag ctatccggcg      540

cgctatgcga acgcaatggc agtcggagct actgatcaaa acaacaaccg cgctagcttt      600

tcacagtatg gcgcaggcct tgacattgtc gcacccgggg taaacgtgca gagcacatac      660

ccaggttcaa cttatgccag cttaaacggt acatcgatgg ctactcctca tgttgcaggt      720

gcggccgccc ttgttaaaca aaagaaccca tcttggtcta atgtacaaat tcgaaatcat      780

ctaaagaata cggcaactag tttaggaagc acgaacttgt atggaagcgg acttgttaac      840

gcagaagcgg caacgcgt                                                    858


<210>  625
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S269_NrdJ-1-IC

<400>  625
atggaagcta aaacctatat cggcaaactg aagagccgta agattgtgtc taacgaagac       60

acctacgata tccagaccag tacgcataac tttttcgcaa atgatatcct ggttcacaat      120

tcaatcagct atccggcgcg ctatgcgaac gcaatggcag tcggagctac tgatcaaaac      180

aacaaccgcg ctagcttttc acagtatggc gcaggccttg acattgtcgc acccggggta      240

aacgtgcaga gcacataccc aggttcaact tatgccagct taaacggtac atcgatggct      300

actcctcatg ttgcaggtgc ggccgccctt gttaaacaaa agaacccatc ttggtctaat      360

gtacaaattc gaaatcatct aaagaatacg gcaactagtt taggaagcac gaacttgtat      420

ggaagcggac ttgttaacgc agaagcggca acgcgt                                456


<210>  626
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S293_NrdJ-1-IC

<400>  626
atggaagcta aaacctatat cggcaaactg aagagccgta agattgtgtc taacgaagac       60

acctacgata tccagaccag tacgcataac tttttcgcaa atgatatcct ggttcacaat      120

agcttttcac agtatggcgc aggccttgac attgtcgcac ccggggtaaa cgtgcagagc      180

acatacccag gttcaactta tgccagctta aacggtacat cgatggctac tcctcatgtt      240

gcaggtgcgg ccgcccttgt taaacaaaag aacccatctt ggtctaatgt acaaattcga      300

aatcatctaa agaatacggc aactagttta ggaagcacga acttgtatgg aagcggactt      360

gttaacgcag aagcggcaac gcgt                                             384


<210>  627
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct S317_NrdJ-1-IC

<400>  627
atggaagcta aaacctatat cggcaaactg aagagccgta agattgtgtc taacgaagac       60

acctacgata tccagaccag tacgcataac tttttcgcaa atgatatcct ggttcacaat      120

tcaacttatg ccagcttaaa cggtacatcg atggctactc ctcatgttgc aggtgcggcc      180

gcccttgtta aacaaaagaa cccatcttgg tctaatgtac aaattcgaaa tcatctaaag      240

aatacggcaa ctagtttagg aagcacgaac ttgtatggaa gcggacttgt taacgcagaa      300

gcggcaacgc gt                                                          312


<210>  628
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct T318_NrdJ-1-IC

<400>  628
atggaagcta aaacctatat cggcaaactg aagagccgta agattgtgtc taacgaagac       60

acctacgata tccagaccag tacgcataac tttttcgcaa atgatatcct ggttcacaat      120

acttatgcca gcttaaacgg tacatcgatg gctactcctc atgttgcagg tgcggccgcc      180

cttgttaaac aaaagaaccc atcttggtct aatgtacaaa ttcgaaatca tctaaagaat      240

acggcaacta gtttaggaag cacgaacttg tatggaagcg gacttgttaa cgcagaagcg      300

gcaacgcgt                                                              309


<210>  629
<211>  7148
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pET22_iSAV_Hwa_S317_nuc

<400>  629
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat      600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg      720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg      960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca     3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg     3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc     3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg     3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca     3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag     3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt     3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc     3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc     3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct     3900

tcggtatcgt cgtatcccac taccgagata tccgcaccaa cgcgcagccc ggactcggta     3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg     4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct     4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga     4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc     4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg     4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct     4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt     4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc     4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc     4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc     4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact     4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga     4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc     4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg     4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag     4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc     4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat     4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc     5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat     5100

ctcgatcccg cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc     5160

cctctagaaa taattttgtt taactttaag aaggagatat acatatgaaa tacctgctgc     5220

cgaccgctgc tgctggtctg ctgctcctcg ctgcccagcc ggcgatggcc atggatatcg     5280

gaattaattc ggatccatgg ctgaagaagc aaaagaaaaa tatttaattg gctttaatga     5340

gcaggaagct gtcagtgagt ttgtagaaca agtagaggca aatgacgagg tcgccattct     5400

ctctgaggaa gaggaagtcg aaattgaatt gcttcatgaa tttgaaacga ttcctgtttt     5460

atccgttgag ttaagcccag aagatgtgga cgcgcttgaa ctcgatccag cgatttctta     5520

tattgaagag gatgcagaag taacgacaat ggcgcaatcg gtaccatggg gaattagccg     5580

tgtgcaagcc ccagctgccc ataaccgtgg attgacaggt tctggtgtaa aagttgctgt     5640

cctcgataca gggatatcca ctcatccaga tctaaatatt cgtggtggcg caagctttgt     5700

accaggggaa ccgtcgactc aagatgggaa tgggcatggc acgcatgtgg ccgggacgat     5760

cgctgcttta aacaattcga ttggcgttct tggcgtagcg ccgagcgctg agctatacgc     5820

tgttaaagtc ctaggggcga gcggttcagg ttcggtcagc tcgattgccc aaggattgga     5880

atgggcaggg aacaatggca tgcacgttgc taatttgagt ttaggaagcc cttcgccaag     5940

tgccacactt gagcaagctg ttaatagcgc gacttctaga ggcgttcttg ttgtagcggc     6000

atctgggaac tcaggtgcag gctcaatcag ctatccggcg cgctatgcga acgcaatggc     6060

agtcggagct actgatcaaa acaacaaccg cgctagcttt tcacagtatg gcgcaggcct     6120

tgacattgtc gcacccgggg taaacgtgca gagcacatac ccaggttgcg tttcggggga     6180

gacagacatc gctctcgtgg agggcaagac cgctactatc ggggagctcg tggagtcggc     6240

gctgacagac ccaaagccgg ttgacgatgg cgtgtgggac accgcggatt tcaccgtgac     6300

gtcggctatc gagacgggcg agctcattga gcgggacgtc acacgcgttt ggaagaggca     6360

gtcccccgag acgatgcggc agatccagat tgctggcggg aggagcgtga cagtcactcc     6420

atcgcacccc gttttcgtgg agcataatgg gtcttacacc gctaggaggg ctgactccct     6480

gagcgctggc gagtcagtgg ctatcgctga cgatgtcgcc gactcacacc cgatttccgt     6540

cgataacact gcgaataccc tcaacccaag gtcgatgtct acgcctggca tcaccacgga     6600

cggcgggctg tacaggacag ggtccgatgg cgggattgtc catgccgagg ttggcaagga     6660

ggacgttact gattgcctca caactgacag gatcaccgct gtgaagaccg tcacgccaac     6720

agctgagtgg gtctacgatc tggaggtgga gggcacacac gcctacctca caaacggggt     6780

tctctcacac aactcaacat atgccagctt aaacggtaca tcgatggcta ctcctcatgt     6840

tgcaggtgcg gccgcccttg ttaaacaaaa gaacccatct tggtctaatg tacaaattcg     6900

aaatcatcta aagaatacgg caactagttt aggaagcacg aacttgtatg gaagcggact     6960

tgttaacgca gaagcggcaa cgcgtctcga gcaccaccac caccaccact gagatccggc     7020

tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactagc     7080

ataacccctt ggggcctcta aacgggtctt gaggggtttt ttgctgaaag gaggaactat     7140

atccggat                                                              7148


<210>  630
<211>  5541
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct p416GALL-Ura

<400>  630
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt       60

cttaggacgg atcgcttgcc tgtaacttac acgcgcctcg tatcttttaa tgatggaata      120

atttgggaat ttactctgtg tttatttatt tttatgtttt gtatttggat tttagaaagt      180

aaataaagaa ggtagaagag ttacggaatg aagaaaaaaa aataaacaaa ggtttaaaaa      240

atttcaacaa aaagcgtact ttacatatat atttattaga caagaaaagc agattaaata      300

gatatacatt cgattaacga taagtaaaat gtaaaatcac aggattttcg tgtgtggtct      360

tctacacaga caagatgaaa caattcggca ttaatacctg agagcaggaa gagcaagata      420

aaaggtagta tttgttggcg atccccctag agtcttttac atcttcggaa aacaaaaact      480

attttttctt taatttcttt ttttactttc tatttttaat ttatatattt atattaaaaa      540

atttaaatta taattatttt tatagcacgt gatgaaaagg acccaggtgg cacttttcgg      600

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg      660

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt      720

attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt      780

gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg      840

ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa      900

cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt      960

gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag     1020

tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt     1080

gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga     1140

ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt     1200

tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta     1260

gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg     1320

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc     1380

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt     1440

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg     1500

gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg     1560

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa     1620

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     1680

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     1740

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     1800

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     1860

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     1920

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     1980

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     2040

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     2100

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc     2160

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     2220

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     2280

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     2340

agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt     2400

cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc     2460

gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc     2520

ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctggcacgac     2580

aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag ttacctcact     2640

cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg tggaattgtg     2700

agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa gcgcgcaatt     2760

aaccctcact aaagggaaca aaagctggag ctcggaagac tctcctccgt gcgtcctcgt     2820

cttcaccggt cgcgttcctg aaacgcagat gtgcctcgcg ccgcactgct ccgaacaata     2880

aagattctac aatactagct tttatggtta tgaagaggaa aaattggcag taacctggcc     2940

ccacaaacct tcaaatgaac gaatcaaatt aacaaccata ggatgataat gcgattagtt     3000

ttttagcctt atttctgggg taattaatca gcgaagcgat gatttttgat ctattaacag     3060

atatataaat gcaaaaactg cataaccact ttaactaata ctttcaacat tttcggtttg     3120

tattacttct tattcaaatg taataaaagt atcaacaaaa aattgttaat atacctctat     3180

actttaacgt caaggagaaa aaaccccgga ttctagaact agtggatccc ccgggctgca     3240

ggaattcgat atcaagctta tcgataccgt cgacctcgag tcatgtaatt agttatgtca     3300

cgcttacatt cacgccctcc ccccacatcc gctctaaccg aaaaggaagg agttagacaa     3360

cctgaagtct aggtccctat ttattttttt atagttatgt tagtattaag aacgttattt     3420

atatttcaaa tttttctttt ttttctgtac agacgcgtgt acgcatgtaa cattatactg     3480

aaaaccttgc ttgagaaggt tttgggacgc tcgaaggctt taatttgcgg ccggtaccca     3540

attcgcccta tagtgagtcg tattacgcgc gctcactggc cgtcgtttta caacgtcgtg     3600

actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca     3660

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga     3720

atggcgaatg gcgcgacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     3780

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     3840

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     3900

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg     3960

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     4020

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct     4080

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     4140

tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt tcctgatgcg     4200

gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atagggtaat aactgatata     4260

attaaattga agctctaatt tgtgagttta gtatacatgc atttacttat aatacagttt     4320

tttagttttg ctggccgcat cttctcaaat atgcttccca gcctgctttt ctgtaacgtt     4380

caccctctac cttagcatcc cttccctttg caaatagtcc tcttccaaca ataataatgt     4440

cagatcctgt agagaccaca tcatccacgg ttctatactg ttgacccaat gcgtctccct     4500

tgtcatctaa acccacaccg ggtgtcataa tcaaccaatc gtaaccttca tctcttccac     4560

ccatgtctct ttgagcaata aagccgataa caaaatcttt gtcgctcttc gcaatgtcaa     4620

cagtaccctt agtatattct ccagtagata gggagccctt gcatgacaat tctgctaaca     4680

tcaaaaggcc tctaggttcc tttgttactt cttctgccgc ctgcttcaaa ccgctaacaa     4740

tacctgggcc caccacaccg tgtgcattcg taatgtctgc ccattctgct attctgtata     4800

cacccgcaga gtactgcaat ttgactgtat taccaatgtc agcaaatttt ctgtcttcga     4860

agagtaaaaa attgtacttg gcggataatg cctttagcgg cttaactgtg ccctccatgg     4920

aaaaatcagt caagatatcc acatgtgttt ttagtaaaca aattttggga cctaatgctt     4980

caactaactc cagtaattcc ttggtggtac gaacatccaa tgaagcacac aagtttgttt     5040

gcttttcgtg catgatatta aatagcttgg cagcaacagg actaggatga gtagcagcac     5100

gttccttata tgtagctttc gacatgattt atcttcgttt cctgcaggtt tttgttctgt     5160

gcagttgggt taagaatact gggcaatttc atgtttcttc aacactacat atgcgtatat     5220

ataccaatct aagtctgtgc tccttccttc gttcttcctt ctgttcggag attaccgaat     5280

caaaaaaatt tcaaagaaac cgaaatcaaa aaaaagaata aaaaaaaaat gatgaattga     5340

attgaaaagc tgtggtatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa     5400

gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg     5460

catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac     5520

cgtcatcacc gaaacgcgcg a                                               5541


<210>  631
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Savinase_BamHIsite_S135

<400>  631
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gatccggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggttc aacatatgcc      960

agcttaaacg gtacatcgat ggctactcct catgttgcag gtgcggccgc ccttgttaaa     1020

caaaagaacc catcttggtc taatgtacaa attcgaaatc atctaaagaa tacggcaact     1080

agtttaggaa gcacgaactt gtatggaagc ggacttgtta acgcagaagc ggcaacgcgt     1140

taa                                                                   1143


<210>  632
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Savinase_BamHIsite_S317

<400>  632
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggatc cacatatgcc      960

agcttaaacg gtacatcgat ggctactcct catgttgcag gtgcggccgc ccttgttaaa     1020

caaaagaacc catcttggtc taatgtacaa attcgaaatc atctaaagaa tacggcaact     1080

agtttaggaa gcacgaactt gtatggaagc ggacttgtta acgcagaagc ggcaacgcgt     1140

taa                                                                   1143


<210>  633
<211>  2064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct intein-modified 
       proSavinase_S317:Unc-ERS_RIR1_var7

<400>  633
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggttg cgttaccgct      960

gacacatggg ttactaccgc tgaggggcca aggcaggtgg aggagttgat cggcaagaag     1020

ttcacggcta tcgttaacgg cgaggagtgg gagtccagcg aggaggggtt cttcgagaca     1080

gacgttaagc cagtgtacac cctgaagacg gctgagggct tcgagctgag gctcacggct     1140

gatcaccctg tcatgaaggt tgagaggatg acacggtaca aggtggagac tcagtggtcc     1200

aacgctggcg acctcaagcc aggggataag atcattatca acaatcatag ggacttcggc     1260

aattggagcg tcaaggggaa gtacaccgag ggcgaggggt acctgattgg cctcctgctc     1320

ggcgacggga cgatcaagaa gctcaacccc tggatgaagg cgatttcaaa gaagatggag     1380

aaggcctccg cagatttctg cgagggcatc ctgagggggc tctccgacgc tgatggctct     1440

gtgcagggga atcagtcgaa gggcgtctct attcgcctgg cccagtcaga cgtcgagatc     1500

ctcaaggcgg ttcagcgcat tctgctcagg ttcggcatct tctcgaaggt gtacatgaac     1560

cgcaggggcg agcggaaggt taagatgccg gatgggaagg gcggggtcaa ggagtacatc     1620

accaagcccc agcacgagct cgtgatcagc aacgacaata tcctctactt cgctgagagg     1680

gtcggcttct cggatgccga gaagatggag aagctggaga aggctatctg gaactacaag     1740

cggaagatga atagggagag gttcgtggct agcgtcgagg aggtggtccc agacggcgtt     1800

gagaaggtgt acgacgttaa gattccaggc atcaatgctt tcaatgctaa tggcttcgtg     1860

gttcacaact caacatatgc cagcttaaac ggtacatcga tggctactcc tcatgttgca     1920

ggtgcggccg cccttgttaa acaaaagaac ccatcttggt ctaatgtaca aattcgaaat     1980

catctaaaga atacggcaac tagtttagga agcacgaact tgtatggaag cggacttgtt     2040

aacgcagaag cggcaacgcg ttaa                                            2064


<210>  634
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Cth_ATPase_BIL codon optimized

<400>  634
tgcttcgtgg cgggcactat gatcctgaca gtcgcggggc tggtcgctat tgagaatatt       60

aaggcggggg acaaggtcat cgctactaac ccggagacat tcgaggtggc tgagaagacc      120

gtcctggaga cctacgtgcg cgagaccacg gagctcctgc acctgacgat caatggcgac      180

gtcattaaga caactttcga gcatctcttc tacgccaagg atgtcgggtt cgttgaggcg      240

aaggagctgc aggtcggcga caagctcctg gattccaagg ggaacgtgct cgtggtcgag      300

gacaagaaga tcaagattac cgatgagccc gttaaggtgt acaatttcca ggttgatgac      360

ttccacacat accacgttgg gtgcaatggg gttctcgttc ataat                      405


<210>  635
<211>  1041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Cwa_RIR1 codon optimized

<400>  635
tgcgtcgcgc cggagacaaa gatcctcaca gacagggggc agatcgccat cgctgacgtc       60

gcgggggaga aggtcaatat ttggaacggg tcggagtggt ctgaggttct cgtgaagaag      120

acaggcgaga accagccgct cctgaaggtg cacttctcaa atggcgagtc cctggactgc      180

acttactacc acaagttcca tgtccaggag aactacaagg ggaaggtcaa gatcgttgag      240

gctaaggacc tccaggaggg cgataagctg attaagtacc ggctcccact ggtggagtcc      300

gagaatgaca tcgatttccc ttacgcctac accagcggct tcttctcggg cgacgggtct      360

catgatggca tggggaagcc ggagattgac ctctacggcg agaagaagga gctcctgccc      420

ttcgtcacgg ttaggaacaa gtactacggc gggtcatacg gcgacaagtc ctggcgcatc      480

gagagggatg aggtggccgt ctacgacgat gttaaccagg accggatcgt gtgcaagctc      540

ccgctggata ttcccgcgaa gttcacagtt cccgtgaatg gctacactat ccagagcagg      600

ctggagtggc tggctggcct cctggacgcg gatgggacag tcgctaggaa cggcgacaat      660

gagagcctgc aggttgcgtc gacccaccag cagttcctcc tggacatccg cctcatgctg      720

cagacgctcg gcgtcgactc taaggtggtc aagatggatg agatggggta caggtcgctg      780

ccagacggca agggcgggta ccaggattac ttctgccagg cgaagtaccg cctcctgatt      840

tccagcaacg gcctcttcca gctgggcgag ctcgggctga agaccaacag gctccagtgg      900

aatctgaggg agcctcagag ggaggcttcc cagttcatca gggtggagaa ggtcgagctc      960

acctgccggt acgacgatac gtactgcttc tcagagccaa agaggcatct cggcatgttc     1020

aatggcatcc tcacagggca g                                               1041


<210>  636
<211>  1821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Dhan_GLT1 codon optimized

<400>  636
tgcctcgctt cggacactct cgttcgcaca tcggaggggg acaagccagt cgctgaggtc       60

gctatcgggg actacctgct ggacgctgag gacaagccag tcctctgcat gggcgctaac      120

ccttcccaga ccgggcgcat gaaggagatc gcttaccagg acttcgattc gaagaagagg      180

gtgtctttca agtgcacacc ggaccaccac ctggagctga cactcactga ttccactccc      240

tccctcagcg gcaagtcagt cacctggttc tccaggtgca cgggggctca cctcagcgag      300

gaggtgtcgg aggtctacct ggacaacatg gtttcgatct tctacaatga tctggttgac      360

tcgacggatt ctgcggtgga caaggattcc attcacgagg ccgtggacct ggcgctggag      420

gatcactacc ataggggcaa ctctgaccag tactcaatcc atctcaatga gtacatcagc      480

cggattgccg ataaggagct gcagaacgag ccggagttca tccgggagtg cattcacgac      540

gccgcgaatc gcttcgtcat cacctccagc ggcaacagga atattaagtc ggagtctttc      600

gacgataagc tcctgctctc acgctccagg tcgtctacag ctgacagcga ttcggactac      660

gtgatcactg acgcctccgt ccactctcat tcaaacaatt catccgtcta cctcgcctca      720

ccagactcca tgatccctga tggcgctgcc aaccgcttcg agaatattgc gtccaagctg      780

aaggagccag tgtgcaactg cggcgggatc cggaagattt tccgcagctt cggcaccacg      840

gaggacgctg agctcgctta ctccctgctc ctgagcgagc actactacag gctggaccca      900

cggttcgtca cagatggcta cactttccag gcctcggttg agcagtacga gaacatgtgc      960

tctcaggagg tgcagaatat gcacctgaag ctctaccgct cacctctcaa gttcgtggag     1020

agggagcata actccgctga gctgccagtc gacccatact tcctgggcct ctggctgggc     1080

gatggggaca gctcggggac aactatcatg accacggatc gggagattgt ggtctggctc     1140

aactcctacg tcgagcgcct gaaccagaat aagccggagg gctgcttccc cctcaagctg     1200

accgagcagc tgatctacgg cgctgggcac acgtccaaga gcgggcatac aactaaggtc     1260

gacgttagga attacaagat ctcttcaggc gatgctttcg tgcggtcggg gacatactgg     1320

aacccgattt tcgacggcct caagaagctg gggctcctga acaataagag cgctggcatc     1380

ccccaggagt acatgaactc tgacgagcag aataggctct cagttattgc cggcctgatg     1440

gattccgacg ggtgctacgt gaagagccac aacacctacc gcttcaccca gctcacggag     1500

gaccataaga agatcgtcta cgatctgaag gagctcgccc tgagctgcgg cattaacacc     1560

acgggggtcg agctctcggt taagccgctg ggcttcaata agcacaagca ttctaccgag     1620

tatgtggtgt acctcggcaa cgggagccag aagttccagg agctcctgct cctgccacgg     1680

aagaagatgg agatcagcaa gaagcacgtg tcgctggacg cgcgcccttt cacggttagc     1740

gacgtggagg atggcgagtt ccgggctatt gaggtttcag ggggggtttt ccagctcgct     1800

aataggctcg tggttgctaa t                                               1821


<210>  637
<211>  882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Fsp-CcI3_RIR1 codon optimized

<400>  637
tgccagccat acgacgctct cgtttcaacg ccatcggggc tcgttcctat cggggctctc       60

gtggagacag acgcggtcgg catgaaggtg ttcgatgcgc acggcctcac acaggtcatt      120

gctactaaga gcaacggggt taaggacgtg ctgaggatct ggacccgcgc gggccacgct      180

ctcgacgtca cggccgatca tctggtttgg aggtccacaa gcgctggcgc tggggctttc      240

gtgccagctg gcgctctcag ggctggggac acactggagt ggcataggac tattgctcca      300

ggcgaggggg agatcacgag ccgcgagatt gctgaggctg ctctcgctgg caggctgcag      360

gctgatggct tcgtcgggcg ctacgctggg accaatgctt cgctcacgat cgaggcgatg      420

accgttccaa cgaggctcta cgacgctcca ctgccagtgg tcgctgccta cctcaggtca      480

ctgttccagg ctgatggcta cgtctcgcgc agggagaggt ctaccctcat cggcctggac      540

atgatttccg aggggctgat caggggcgtt caggggctcc tggctaggtt cggcatcttc      600

gccagggtgc ggagggaggc tgatccacgc cctgacaggc acgatctctg gtccctgggc      660

attcagaacg ctggggacag gcggaccttc gccgatgaga tcggcttcct cgacccagtg      720

aaggcggcta agctggaggc ttccttcgac cagccaggcc aggctgctaa gcctgtcaag      780

aggctccaga tcgagaggat tgagccgagg ggcccgatgc ccgtctacga cattcagaca      840

gattccgggg agtacctctc tgctgggctc agggttcata ac                         882


<210>  638
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Gob_Hyp codon optimized

<400>  638
tgccagcctg cggggacaca ggtcgctaag gttattaagg aggggaggtg gagggaggat       60

tcggttattg agcaggttcc tattgagtca ctccagccag gcgacagggt ggtctccttc      120

gggaacgcga agatctaccg caggggccgc gctgtgacag ggattacttc ccggcgccac      180

acaggcaatc tgcatagggt cgaggttggg gagttccgca ccagggccac gccagagcac      240

aggttcaccg tccggttcga cccagctagg cctaaggctg gcctcctgta cctcatgagg      300

aggggcgata ggtggagggt gggcgtctgc gggatgttca actcgcgcgg cttcggggtt      360

tccgtgcggc tgagccagga gaggggcgac gctgcttggg tgctcggggc cttcgcgaca      420

ctgactgagg ctaggatcgc cgagcaggtt gtgagctgcc ggtacggcat tccaaccacg      480

gtctgggaga ccggcaggaa tcctggggct tcgtgggctc agagggacca ggctggcatc      540

gatgccatct accagaggct cggcgtcgat aggatccggg ctggggttga caggctcctg      600

agggatcacg gcctctctgc tgggctgcca ctcctggctg ccaacgagcc cggcaatttc      660

tcgtgcaggc agtctaggca ggtggctgct tgcaacctgg tgccaggcgt catgcaggtc      720

ccagttccaa cggctggcga gaggttcgag tggagggacc tcaccgctac gagcttcgag      780

agggttcatg atctggaggt gtggagcatg gatgtggaga gggataagca ttacgttgcg      840

gatggcatcg ttgtgcataa c                                                861


<210>  639
<211>  1236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Gvi_RIR1-1 codon optimized

<400>  639
tgcttcgctg cggggacgct gctgcatact gagcagggct acgttccggt ggagcaggtc       60

gtggcggggg tcgggacaag ggtttgcaca caccagggct tccggaacat ctctgagcgc      120

ttcgataatg gggaggccga ggttttcagg gtgaccacgc ggaagggcta ctccgtggag      180

gtcactgcga accacaagat ggctcgcctc gacgagaatg gcgatctcct gctcgacgag      240

ctctcacatc tgcaagtggg cgacaacctg ctcctgctcc tggggtccaa tccggtgacc      300

gagaaggtcc ggctgcagtg catcccagct ggctaccgct ccagcatcga gattgctcag      360

ccgcccgagc tcgatgagca gctggcttac ctcctgggct acgcctacgg cgacgggtgc      420

gtcggcaggg gggctacata caactacctc agcctggctg tgtcgcacac ttacccgaat      480

gtccgcgacc agctcgccgc gatcattagg gagaagttcg gcctgacaac taagatctac      540

tcaggctccg gggcggtttg gaacctcctg gtgcattccg ccaatctcct ggattggctc      600

aaggcgaacg gcctcctgaa gcagaaggct gcggacctcg ccatgccaga ggcgattctg      660

cgctcgcctt cgtctgtggt cggcgctttc ctgtctgggt acttcgacgc tgatggctgc      720

gtgaggggcg ggaagggcgg gtacgggttc gattgcacga gcaaggcttt cgtcggcgct      780

gttcagctcc tgctcctggc cgaggggatc gtgtccaacc tccacaccac ggaccggagc      840

cgccagggct ggcgcacaat ctacaggctc aatgtctgcg gcaccgagtt caagcgcagg      900

ttccagacgc tgtgctgcag gtctgcgaag gttgtgcatt caccaatggt gctcggcagg      960

gatgggaccg gcgggtaccc acctgctctg gttaggggcg cttcgtacca gagggtcgtt     1020

gctgtcggcg ggaagcacct cctgtacacg gcgctcctga aggtcatcga gaagacaagg     1080

actgctggca agcaggctct cgctgagagc ctgtgccagc atgtcaacta cttcccggac     1140

cccatcgtcg cgattgagtc ggttggcacg cagagggttt acgatattga ggtggagggc     1200

atgcatctgc tcggcaatgg catctacaca agcaac                               1236


<210>  640
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Hhal_DnaB-1 codon optimized

<400>  640
tgcctcgcct acgacgcgga gatcgttcag gctgacgggg gggttaagac tattgagcag       60

atcgttaggg agcggcgggc gcatctcgct acggtcggcg ctgactggag gctgacatgg      120

actgagccgt gcgattacgt tgacgatggc cacaagcccg tcttcgaggt taccacgcgc      180

ctcgggcgca ggatcgagac aactctgaca cacccgttcc tcactgtcca tggctggcag      240

aggctggagg acctcgctga gggcgatgct atcggggtcc caaggcagct gccagttttc      300

ggccaggagc ccattaggga ctgcgaggtg aggctcctgg gccacctgat cggggatggc      360

gggctcaccg gctcgccacc caggctgacg tctgggcagg aggcgatgac agctgacttc      420

ctggaggctg tggatgcttt cggcggggtc gaggctaagc caatcagggc gtcccggagg      480

acgcagagct gggtggtcgt tggcgctgct caggcccgcg ctgctgctag gtccagcttc      540

gcttcactgg tcgacgccct cattaggagg tcccctctca ccggcagggc tatcgctagg      600

aacctggggg tggcgccagc taccctcacg tactggaggc agggcgtgaa tgtccctgac      660

gctgctatgg ttgggctcct ggctggcgag ctgggggttg atgtgggcga gctcaggcca      720

gagcctgtgg ctcgcaggaa cgaccgcaat ccactgcagg cttggctcga taggctgggc      780

ctcgctggga agtccgctca cgagaagact gtgccagact gcgtcttccg gctgcctcgc      840

gagcagctcg ctaggttcct gaaccggctc ttctcgtctg acgggtgggt gacacatctg      900

gctagcggcc aggggcagat tggctacacc acggtctcgg aggctctcgc taggcagatc      960

cagcacctcc tgctccggtt cggcgttctg gctaagctca ggcataggtc cgtgcgctac     1020

caggacggca ggaggccagc ctggcagctg gatattactc acgcggagag catcctcacc     1080

ttcgctgagc agatcggcat tctggggaag gagcagcggc tcgcctctgt tgctgcttca     1140

gtgcgcggca ggaggaggca gtcgcacacg gaccatatcc cctgcgagat ttggcagttc     1200

atcgataggg ccaggggcga gtggacatgg gctgagctgg ctaggagggc tggggtcgct     1260

tcatccaata tccacgccta caggaggggc atgtctaggc agaggctggc tgctttcgct     1320

gacgctctcg gctcaaggga gctgaggcag ctcgcgagct cggacctgta ctgggatcgg     1380

atcgcctcca ttcgcccgct cggccataag caggtgtacg atctcactat tccagagact     1440

cataacttca ttgctaatga tgtttgcgtg cataat                               1476


<210>  641
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Hma_CDC21 codon optimized

<400>  641
tgcgtgcatg gggatacaag ggttactctc gctgatgggc atgagcggcc tattcgggag       60

gtcgtggagt caaatctgga tgatccgaag ccagtcgacg atggggtttg ggataccgtg      120

gacttcgatg tcccttctct gcagtcagac ggcacagttg cgactcagaa cgctacgaaa      180

gtgtggaagc ggaaggcgcc ggagacactc taccgcatca ggaccgctac gggcagggag      240

ctggatgtca caccatcaca ccctctcttc gttcagtccg acgggaggtt ccaggctagg      300

aaggctgagg agctggagtc tggcacccat gttgctgtgc ccaggaaggt ttcaactaac      360

gcctgcaatg agctcgacgt caccttccgg cagtctcagg cccacaaccg catcgacctc      420

gatctgccac cacagtggac gccagagctc gctaggctga tcgggtacat tgttgcggag      480

ggctacgtgg agcagaggcc tgataatacg ggctacgtgt ccatcacaaa caatgaccgg      540

gaggtgctgg acgatgccaa gagcgtcctg gagactctca acctgaatgt caccgagcgc      600

tccagccacg aggggaagac ggcgagggag ctcctgtgca gcgctggcga gttcgtgtcc      660

ttcctcgcca gcctggacga gacactcctg cagtcgtctg ctgagaggag ggtcccgcag      720

gatattatga gggcttccga caacgtggtc accgggttca ttcggggcta catcgagggg      780

gagggccatg tgtcaacgtc ccagcgcgag atcacagtcg cgagcatgtc gaagccgctc      840

ctggaggacg tcaggaccct cctggttacg cagggcatta cagcccagct gcagccccgg      900

aacaatgggt cctacaggct caggatctcc ggccagagct tccacgacta cgcggagcag      960

atcggcttca ttactgcccg caagaccgag gcttgcaggc agttcgaggg gacgcatggc     1020

aacacaaatc tggacattgt gccgaacctg ggcccagagc tcaggcgcat ccgcgaggct     1080

ctcgggctga ctcagagcga gtgcggcctc ccaaggtcga cctaccagca ctacgagagg     1140

ggcaggagga atccctcgcg ggattctctg gagtcagtgc tcgacgcttt cgagactagg     1200

ctggccgaga tgaacaatga cactccaatt tcggataccg ctaggtctga cggcgggggc     1260

acgggctcgc tcaggcagga tctcaacggg ctggctgctc tcgtggaggg cgacatcgcc     1320

tgggatcgca tcgagtccat tgagcctatc gagcatgacg agaagtgggt ctacgatctg     1380

gagattgagg gcacacataa ctacctcaca aatggggtcg tctctcataa t              1431


<210>  642
<211>  627
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Hwa_MCM-1 codon optimized

<400>  642
tgcgtttcgg gggagacaga catcgctctc gtggagggca agaccgctac tatcggggag       60

ctcgtggagt cggcgctgac agacccaaag ccggttgacg atggcgtgtg ggacaccgcg      120

gatttcaccg tgacgtcggc tatcgagacg ggcgagctca ttgagcggga cgtcacacgc      180

gtttggaaga ggcagtcccc cgagacgatg cggcagatcc agattgctgg cgggaggagc      240

gtgacagtca ctccatcgca ccccgttttc gtggagcata atgggtctta caccgctagg      300

agggctgact ccctgagcgc tggcgagtca gtggctatcg ctgacgatgt cgccgactca      360

cacccgattt ccgtcgataa cactgcgaat accctcaacc caaggtcgat gtctacgcct      420

ggcatcacca cggacggcgg gctgtacagg acagggtccg atggcgggat tgtccatgcc      480

gaggttggca aggaggacgt tactgattgc ctcacaactg acaggatcac cgctgtgaag      540

accgtcacgc caacagctga gtgggtctac gatctggagg tggagggcac acacgcctac      600

ctcacaaacg gggttctctc acacaac                                          627


<210>  643
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Hwa_PolB-2 codon optimized

<400>  643
tgcttcactc ctgatacaaa tgttctgacg cctaatgggg ttcgcaatat tcgggatctc       60

acggtcgggg attcggttta ctcgctgaac ccggagacca tgcagatgga gatcaagccg      120

gtgacacaga ctcacgagta ccccgactac cagggcgacc tcatcgatat tcagacaaac      180

gagatcgatt tccgcgtcac tccaaatcat aggatgctgg ttgaggctac cggcacggac      240

accacgtcca ccaacgacta cgatttcatc gaggccggga atctcgatat ttccagccgg      300

tacgagctgc ctcacggctg gtccgttgac catacggata gcctcggggc ctacatcgac      360

ctgattaccc tcctgaggga gcagtcagac acgtacaacg tcctctccga tggcgggatg      420

acaactgctg ctacggctga catcaatcac aacaatgtca cccgcagggt tgactctgat      480

acgttcgtgt cactgattgg ctggtatgtg gctacagggc gggtctcgcg cactcagaac      540

ggctctgaca gggtctacct ccagctgtcc cagacaaata ctaaggcgcg gacccagctc      600

acgatgctcc tggacgagct gggcgtggac tggcaggctg ataacgagaa gatccacttc      660

gtgtctcatg tctggacgga gctcttcgac accacgtgcg gccgcacaga gaagaacaag      720

cacatcccgg agctgatttt cgacgcttca gcctcccaga agagggcgtt cttcgatgct      780

atcattaacg gcagcggggt caagaatgac gattcgtacc agtaccacac ctcgtctgag      840

gacctcaggg acgatatcct ccggctgtgc gttcatatcg gcattgtggc gcggtacgac      900

tacatcaacg atgagtcctg gcgcattgag tgcaccgaga cggccaatcc cgacttcaca      960

ctgactcata gcggcaggca gtcgacagct gaggatgggg tttactgcgt gactgtggcg     1020

gataatcaga ctctgctcgc cgggaggaat ggcaccttcc agtggacagg caac           1074


<210>  644
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Hwa_RIR1-1 codon optimized

<400>  644
tgcctcactg cggactcaac agtcatgctc aaggagaagg ggatggtctc ggtctcggag       60

gtggagacag gggatcagat cgctcagcgc tccgacacag gcttccagta caagccggtg      120

gaggagactc acgcgtacga gaacgctgag acactcactg tcaccctgac gaacggctgc      180

tctatccgcg ggaccccgaa tcacaggctc atggtcgacg atgagtggac gcgcatcgac      240

gagattcagc ccgatcagga ggttcattac acactcggct ggctgaggga gactaaccag      300

tccccgccca agctccactc tcagtcacat accacggtga atcagacagc tgactccatc      360

agcccggatt ccagcgagcc cattgagctg tcggagtctg agaacgcgga cacgggcaac      420

aggcacaatt ctgctgttgc cgtgaagcag tcacggacac agactcagct gatcagcgac      480

gaggtggtct cgcggccaga gcacaccagg aggcctgatc agctctccga ggagctggct      540

gagctcctgg gcctctggat cgacacgggg ctgtggcatc agagcggcgt ccagttcaac      600

gttgagcgcg agaatatcgc ggagtacatt gaccagctct cacagcagct gttcgatacc      660

ccagctgcta tctccgacac ggatggcacc tacacggtgg acattacaga tcataagctc      720

aaggagtggt ggaaggctaa cttcggcggg aagccagacg gcactcagtc gtcttacgtc      780

ccacagatga tcaaggaggc ccctacaaat gttattgagg cgttcctgag ggggtgcttc      840

actgctgagg gcgggctcag gaaggacatg aggccacggc tgtgcacctc atccgaggat      900

agcatcgacg atattgcggt cctcatgatg ggcctggggt accctgtgga gaagtcggtc      960

atcaggaacg ctgacggcga gccgtactac tcggttatgc ccgctaccga cgatgggctc     1020

tctgccttcc tgcacgacgt gggcttcatc gatgagcggc gcgagatcgg gctctccaac     1080

attgagagct cggatagccg ggccctgaac aatacccata agatcgaggt tgagtcaatt     1140

gtggagtccc cacctgcgac ggtctacgac attacagtgg cggataatca tgagtacgtt     1200

acagatggca tcatttcaca caac                                            1224


<210>  645
<211>  1314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Hwa_RIR1-2 codon optimized

<400>  645
tgcgtggagg agaatagcct ggtttctacc gatgaggggc tgcggcctat caaggatctg       60

gacaatacta ctgcggagtt cgagcagtgg gacgagatcg atgtcggcgt taccacggac      120

ggcgggacca agacggctac agctgtttac gataacggct tcgccaatgt gcgccagatc      180

cagaccgaga gcgggttcaa cattgctgct accccaaatc accggttccg cacgctgtcc      240

agcgacggca cttacacctg gaaggaggct ggcaagttcg agtccgggga ccgcgtgatc      300

ctgcagagga acaccttcga tgctggctcc cgcgtgtccc tggaggctaa tgagagggct      360

gacgatgccc aggacacaac tgagggccca gagctgccag ggaggatgac gtccgagctg      420

gccgagttcc tcggctactt catgggcagc gggtacatct cggacgagac ccatgcttcc      480

gtggatctgg tggtcgacag cgatgccacg gagctcaact catacctgtc caatctcggc      540

gagcagctct tcaggattac cccggccgtc gagtctcagg agatgtcaca ggttctgtcc      600

ttccgggact gccacctcag ccgctacttc gaggataacg gctggaagaa gacggacaca      660

ggccataatg gggatgcttc ggctgctttc gtcccagagc agatcctgga gggcgacgag      720

caggttgtga acggcttcct caggggggtg ttcgaggcga ttgggacggt ctcggagaag      780

atcgagattc tgaccacgtc tacaactctg gctgaccagc tccagagcct cctgctctcg      840

ctgggccacg tgttcacccg ggatagcacg aagctcgtcg agacaaacaa ttaccatgac      900

gatcagctga ggcagaggct ctgcggcgct actaggaggg aggacgagcg gttcatgaac      960

gagatcgggt cactcattga gccagatgag ctgaacctct ccacacgcgc ggacaagaat     1020

gatacttacc cttcgtctgt tatcgaccac gtgcagacac tggacggcta cgattcagtg     1080

tccgagagcc tcaagtctcg cattaaccag tcacaggtcg acgggacggt tagcaggaag     1140

ctgatcaagg atattgaggc ggagactgct gagaccgtct cgatcgccga ccatgagctc     1200

acaggcttct acgcggctac tgtggagtct gtcacggagg acacagcgta cactaaggat     1260

atttcagttc caagcaacaa cacatacatc gccgacgggt tcgttactca taat           1314


<210>  646
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Hwa_rPol_App codon optimized

<400>  646
tctattgagg ctgatgagtc aatcgttatt aggcgggacg gggagactga gctgacggag       60

atcgggtcgt tcgtggacac tattctggcc gcggacaacc aggagacccg gatcacggat      120

ggccacgaga ttgcgctcgc tccgaatggg ctggaggttc cctccctcga caccgatgag      180

cagatcaggt ggaagcacat tgaggcggtg agccggcatg cttcgccaga cgagatcctc      240

ctgattgagc tggagtcagg caggtccatc agggctacca aggctcactc cttcgtcacg      300

aggagggacg gcgatgttct cccagtggct ggcgagacac tggtggtcgg ggacgtcctc      360

cctactgttg gcagctacga tcatgcgtcg gggtctatct cagtgccgct gcagtcccag      420

agcgtcgctg ctgacggcgg gaccgttgag cccaacacaa atatcactgc caacgcggag      480

cgcgattcgg cctctattac ctctgcgggc atcattgggt cggctacgtg ggagaggatc      540

tccagcattg agacagtggc gccggagtac gagtatgtgt acgatctctc tgtttccggg      600

ctggagactt tcactacggg ggagggggtc gttactcata at                         642


<210>  647
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Kra_DnaB codon optimized

<400>  647
tgcctcactg cggggacaag ggttctgcgg gctgatacgg gggcggagac tactatgggg       60

gagctgttcg cgctgcaggc tagggacgtt ccggtgtggt cactcgacga gtccctgcgc      120

tacgtccgca ggcacctcac tagggttttc ccaaccgggg tgaagccagt cttccggctg      180

aggactgcta gcggcaagac tgtccgcgct accgctaacc atccattcct cacctacgat      240

gggtggaagc ctctcggcga gctgtcggtg gctgacaggc tggcggttcc gaggcacgtg      300

ccagctccag agagggtggc ttcatggacg gacgatcagg tcctcctgct cggccatctc      360

atcggcgatg ggtccttcgt caagaggcag ccactccgct acgctagcgt tgacgaggct      420

aacctgtcgg ctgtgacgga ggctgctgct aatgccttct ccattgtcgc ggttcgggac      480

gagtacgctg ctgctaggtg caccacgctc aggctgccag ctccttacag gctgacccac      540

ggcaggagga atccactcgc tgcttggctg gacgagctcg gcctgttcgg gctcaggagc      600

tacgagaagt tcgtcccgca ggaggttttc cacctgccca agaggcagat cgctctcttc      660

ctgcggcatc tctgggcgac tgatggctct gtgacgctga caaggcagtc acgcggcggg      720

aggatctact acgcctcgac atctctccag ctgattcagg acgtctccag gctgctcctg      780

cggttcggca ttagcacgag ggtgcggaca actaccccaa agggggacca caggcctggc      840

tacacactcg atgtttctgg cgtggacgat cagaggcggt tcctgcagga gatcggcgtc      900

catggggcca ggggcgctac cgctgacagg ctcctggagg tcatcaggga tgtctccgcg      960

aacacgaatg tcgacacagt tcccaggcag gtttgggacg atgtgcgcag gctcctggtg     1020

gagaaggaga tgacgcacag ggagttcgct gctgctatgg ggacatcgtt cggcgggtcc     1080

agcctctgga agcatgctcc atctcgcgag aggctcggca gggtggccca ggtcctggac     1140

tcggccgagc tcgatgttct ggcggtgaac gacgtcctgt gggatgaggt ggtcgcgatc     1200

gagcctgacg gcgaggagca ggtctacgat gctactgttc tcggggggca caacttcgtg     1260

gcggatggca ttgctgttca taat                                            1284


<210>  648
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Mca_RIR1 codon optimized

<400>  648
tgcgttacgg ctgacacatg ggttatgacg gcctcggggg ctaggcaggt tcgggatctc       60

attgacaggc cattcgaggc ggtcgtggac ggcgagtgcc acccaacaga gtcccgcggc      120

ttcttcttca ctggggataa gcctgtgctc aggctgtcga cggctgaggg ccacacactc      180

aggctgactg cgaaccatcc ggttctcagg gtgtccaaga tgaccaggca gctgcgggag      240

acggagtggg ttaaggctgg cgagctcagg ccacacgaca agatcgtcct ccacgatcat      300

agggctctgc catcctggga cggcgctcat accgaggctg agggctacct gatcgggctc      360

ctgattggcg ggggcaccct cacgagggac aaggctatcc tgtctatttg ggatgctgct      420

gctccaaagg tggctaacgg gggcggctca gtcccagctg ctggcgtcgc cggggttatg      480

agggctgctg agctcgctgc tcggaccctg ccacaccgca cggacttcaa tggctggcag      540

accacgatgg agggcagggg ggagtaccac atggctacag gcgccctcca tactctcgct      600

ctggagctcg gcctgacacc aggggataag cgcctcactg cgcctctgga gacaacttcc      660

agcgctttcc acaggggcct cctgaggggg atgttcgacg ccgatggctc ggttcagggg      720

tctcagagga agggcgtgtc catcaggctc ccacagaccg acctcgggaa cctgcagacg      780

gtccagagga tgctcctgag gctgggcgtt gctagcacca ttcatcagaa taggaggcca      840

ggcgggacca aggtcctccc agatggcgag ggcggggcta aggggcactc atgccaggcc      900

gcgcatgagc tgatcatttc cggcgagaat gtggtcaggt acgctgagcg gatcggcttc      960

gccgactcgg ataagatgga caggctcacc gctctcctgc agaggtacag gcacacgagg     1020

catgctgaga ggttcatcgc gacagtgcag agcctggagg acgatggcat ggaggccgtc     1080

tacgatgtta cagtggcgga cgttcatgct ttcgatgcta atgggctcta cgttcataat     1140


<210>  649
<211>  495
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Memar_Pol-II codon optimized

<400>  649
tgcttcgcgg gggacactga gattactgtt tcggacgggc ggcgctggat gtcgctccct       60

attaggcagt tcgttactga gaatttcgac atctcaaagc cgggcctcga tcacgttggg      120

acattctact ccgacccaag gcagccattc tacgtccgct cgattgattc tcagggcaag      180

acaagcctca agcgggtgac ttccgtcagc gttcacaggg ctccagctca tctggtccgg      240

ttcgctacca ggagggggag ggtcctcacc gttacgcctg accatgcgat gctggtgtgg      300

gacacggatt acctccgcaa gatcaaggct ctggaggtgg ctgtcggcga cagggttcca      360

gtggaggagg gcgggctcgt ggtcgctgat gaggttgtgt ctagggagac ggtgcaggct      420

ctggacgatc gggtctactg cctcactgtg gcggagaatc atactctcgt tgctaatggc      480

atcttctgcg ggcag                                                       495


<210>  650
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Mex_helicase codon optimized

<400>  650
tgcttcgctg cgggcactct catcaagaca ccaaaggggc ctgttcctat tgagcagatt       60

cagtcggggg atctcgtttt caatgcgatc ggcattgggg tggtcgaggg catcgtgtgc      120

cagcagaagc agaccattac gctggagctg tctgacggca catcaatcgt ctgcactcac      180

gatcatccat tcttctgccc tcgcggctgg gtcgctgctg gcgacctgga ggttggctcc      240

gggctgttca gccacgagga tctccgcagg ctgtggtcgg gcggggcttc tctcggcctg      300

gagtccgggt ccagcgacgg caggggggct gttcgctcgt ctgaggtgct cctgaggatc      360

ctcagggagg aggctcgcga gccagatgct ggctactgcg ggccagccga ggacgtgcgc      420

aacgcgtcta ccgatagggc tcatgctgag ggcgcttggt ggcagtggca ggctgacccg      480

attgcgtcag atgaggctgc taggtccgct ggcaggaggg tcgctgaccg cgttagggac      540

gaggatagga gggaggctag gccagagcca accgctgtcc tcctgcagga caggcactgc      600

gagccactgg ctaacgatcg gaataggagc ggcagggagc attcatcccg gggcacgggg      660

gaggctgagg gccagcggca gggggacgtg ccatgctcgg tccgcgttgt gagcatctcg      720

cgcgaggaga ggggcgggcc tgaggcggtg tacaacctca gggtttcagg gcatccaagc      780

tacttcgctg ggggggttct cgttcataat                                       810


<210>  651
<211>  495
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Mhu_Pol-II codon optimized

<400>  651
tgcttccatg gggacacact cattgagatc tacgctgacg gcattctgga ggagattccg       60

atcaggcggt tcgttctgga gcatctggat ctctcgcagg ctggcgtgga cgctctgggg      120

acgttctacg ctgatccggt ccggccagct cacgtgcgct ccgtcgacac aggcgggatc      180

ccacacctcc gcaagattac ttccgttagc gtgcataagg cccctgcgaa cctgatccag      240

ttctcgacct ctaggggcaa gaatctcctg gtgacgccgg atcatgctat gctcgtttgg      300

gacgtgtcct acctccgcaa gatcagggcc ctggaggtca agattggcga cgctgtccca      360

gtttgggagt caggggtggt catctccgac aggatcgtca gcattgatta cgttccctgc      420

gaggacgagc gggtgtactg cctcactgtg gatagggatc ataatgttgt gggcaatggc      480

atcttcactg ggcag                                                       495


<210>  652
<211>  504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Mja_Klba codon optimized

<400>  652
gctctcgcct acgatgagcc tatctacctc tcggatggca acattatcaa tatcggggag       60

ttcgtggata agttcttcaa gaagtacaag aacagcatca agaaggagga caatggcttc      120

gggtggatcg atattggcaa cgagaatatc tacattaagt ccttcaacaa gctcagcctg      180

atcattgagg acaagcggat cctccgcgtc tggcgcaaga agtactcggg gaagctgatc      240

aagattacca cgaagaaccg cagggagatc acactcactc acgatcatcc ggtttacatc      300

tctaagaccg gcgaggtgct ggagattaat gccgagatgg tgaaggtcgg ggactacatc      360

tacattccca agaacaatac catcaacctc gatgaggtta ttaaggtgga gacggtcgac      420

tacaatggcc acatctacga tctgactgtg gaggataatc atacttacat tgctggcaag      480

aatgagggct tcgctgtttc caac                                             504


<210>  653
<211>  1236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Mja_PEP codon optimized

<400>  653
tgcattgagg gggacgctaa gattctgacg gatcgggggt tcctgaagat gaaggaggtt       60

tacaagctcg tgaagaatgg ggagaagctc aaggtcctcg gcctgaatgc tgagacactg      120

aagactgagt ggaaggagat cattgacgct cagaagaggg aggctaggcg ctacgagatc      180

ggcgtgtacc gcaagaataa gaacaccaag gacacgatca agattacacc ggatcacaag      240

ttccccgtgt tcgtcaacgg cgagctcagc aaggtgcagc tgtgcgacat cattgataac      300

aatctctcag tcctgtccat cgactacatt ccaatgatcg aggagaagta cgagtccctc      360

gctgaggtca tgtacctcgg cggggctgtc ctgagcgatg gccatatcgt tcggaggaac      420

gggaagccaa ttcgggtccg cttcacacag aaggacactg aggagaagaa ggatttcatc      480

gagaaggtta agggcgacgt gaagctcatc ggcgggaatt tcatcgagat ttcgaaccgc      540

aacaatgtca tcgagtacca gacctctagg aagattccgt cagagatcct gggcttcatt      600

gaggttaata ttaacacaat ccccctctac gccactaagg acgagatcgc cgatctgatt      660

gcgggcttcg ttgacggcga tgggtgcctc tccgggaaga ggagggtgga gatctaccag      720

aactccagcc acattaagaa gatcgagggc ctcatcgtcg ggctctacag gctgggcatc      780

attccgaggc tgcggtacaa gcggtcgtct accgcgacga tctacttcaa caacaacctg      840

gagaccatcc tgcagcgcac gcgcaggatt aagctcgaca agctgaagga gttcaagaag      900

ccagtggagg acaagaagct gatcgatatt tcgcagatcc tccctgagct gaaggagttc      960

gactacaagg gctacctcta caagacctac aaggagaagc tgttcatcgg gattaacaag     1020

ctggaggagt acctgtctaa gatcgacaag gatggcattg agcgcatcaa gcagaagatc     1080

aagctcctga aggagagcga catctactcg atcaggatta agaaggtcgg cgaggattac     1140

ggggaggtct acaatatcac ggttaaggcg gagaacgagt tcaatcataa ctacgtggtt     1200

tggactaagc attacacacc tatcgtggtt ttcaac                               1236


<210>  654
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Mja_Pol-2 codon optimized

<400>  654
agcattctcc ctgacgagta cctgactatt attgaggagg atggcattaa ggtcgtgaag       60

atcggggagt acattgatga tctcatgcgc aagcacaagg acaagatcaa gttctcgggc      120

atctctgaga ttctggagac aaagaacctc aagactttct ccttcgataa gatcacgaag      180

aagtgcgaga ttaagaaggt gaaggcgctg atcaggcacc catacttcgg caaggcttac      240

aagatcaagc tccggtctgg ccgcaccatt aaggtcacga gggggcattc actgttcaag      300

tacgagaacg ggaagatcgt cgaggttaag ggcgacgatg tgcggttcgg ggacctgatc      360

gtggtcccaa agaagctcac ctgcgtcgat aaggaggttg tgatcaacat tcctaagcgg      420

ctgatcaatg ctgacgagga ggagatcaag gatctcgtca ttaccaagca caaggacaag      480

gccttcttcg ttaagctcaa gaagacgctg gaggatatcg agaacaataa gctcaaggtc      540

atcttcgacg attgcattct ctacctgaag gagctcggcc tgatcgacta caacatcatt      600

aagaagatta ataaggttga catcaagatt ctggatgagg agaagttcaa ggcctacaag      660

aagtacttcg acaccgtcat cgagcatggc aacttcaaga aggggcgctg caatattcag      720

tacatcaaga ttaaggacta catcgcgaac attcccgaca aggagttcga ggattgcgag      780

atcggcgcct actcggggaa gattaatgcg ctcctgaagc tcgacgagaa gctggctaag      840

ttcctcggct tcttcgtgac acgcgggagg ctgaagaagc agaagctcaa gggcgagact      900

gtctacgaga tctcagttta caagtccctc ccggagtacc agaaggagat cgctgagaca      960

ttcaaggagg tcttcggcgc cgggtccatg gttaaggaca aagtgactat ggataacaag     1020

atcgtgtacc tcgtcctgaa gtacattttc aagtgcggcg acaaggataa gaagcacatc     1080

cccgaggagc tcttcctggc ctccgagagc gtgatcaaga gcttcctgga cggcttcctc     1140

aaggccaaga agaacagcca taaggggacc tcgacgttca tggcgaagga tgagaagtac     1200

ctcaaccagc tgatgatcct cttcaatctg gttggcattc cgacaaggtt cactcccgtg     1260

aagaacaagg gctacaagct caccctgaat ccgaagtacg ggacggtgaa ggacctcatg     1320

ctggatgagg tcaaggagat cgaggcgttc gagtacagcg gctacgtcta cgatctctct     1380

gtggaggata atgagaactt cctcgtcaac aacatctacg ctcataat                  1428


<210>  655
<211>  1629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Mja_RFC-3 codon optimized

<400>  655
tgcctgacgg gggacgctaa gattactctg cctgacgagc gggagatcaa gattgaggat       60

ttcattaaga tgttcgagga gcgcaagctg aagcacgtcc tcaacaggaa tggggaggac      120

ctggtgctcg ctggcgtcaa gttcaactcc aagatcgtta atcacaaggt gtacaggctg      180

gtcctggaga gcgggaggga gatcgaggct accggcgacc ataagttcct gacgagggat      240

ggctggaagg aggtgtacga gctcaaggag gacgatgagg ttctggtgta cccggctctg      300

gagggcgttg ggttcgaggt ggacgagcgc aggatcattg gcctgaacga gttctacgag      360

ttcctcacaa attacgagat caagctgggg tacaagccac tcggcaaggc gaagtcatac      420

aaggagctga ttactcgcga caaggagaag atcctctcta gggtcctgga gctctccgat      480

aagtactcca agagcgagat ccggcgcaag attgaggagg agttcggcat caagatttct      540

ctgaccacga tcaagaacct cattaatggg aagatcgacg gcttcgccct gaagtatgtg      600

cgcaagatca aggagctcgg ctgggatgag atcacctacg acgatgagaa ggctgggatc      660

ttcgccaggc tcctgggctt catcattggc gacgggcacc tgtcgaagtc taaggagggc      720

cggatcctga ttacagctac tattaacgag ctggagggga tcaagaagga tctggagaag      780

ctcggcatca aggcctcgaa catcattgag aaggacattg agcataagct cgatgggagg      840

gagatcaagg gcaagacctc tttcatctac attaacaata aggccttcta cctcctgctc      900

aacttctggg gggtcgagat tggcaataag acgatcaacg ggtacaatat tccaaagtgg      960

atcaagtacg gcaacaagtt cgttaagagg gagttcctga ggggcctctt cggggctgac     1020

ggcacaaagc cttacatcaa gaagtacaac atcaatggga ttaagctggg cattcgggtg     1080

gagaacatct ccaaggataa gactctggag ttcttcgagg aggtcaagaa gatgctggag     1140

gagttcgagg tcgagagcta cattaaggtt tcgaagatcg acaacaagaa tctgaccgag     1200

ctcatcgtca aggccaacaa taagaactac ctgaagtacc tctcaaggat ctcctacgcg     1260

tacgagaagg acaatttcgc taggctggtg ggcgagtacc tccggatcaa ggaggcgtac     1320

aaggacatca ttctgaagga gatcgccgag aacgcgctca aggaggccga tggcgagaag     1380

agcctgaggg agctcgctag gaagtacaac gtcccggttg acttcatcat taatcagctg     1440

aaggggaagg atatcggcct cccccgcaac ttcatgacgt tcgaggagtt cctcaaggag     1500

aaggtggtcg acggcaagta tgtgtccgag cggatcatta agaaggagtg catcggctac     1560

cgcgatgtgt acgacattac ttgccacaag gatccttctt tcattgctaa cggcttcgtc     1620

tctcataac                                                             1629


<210>  656
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Mja_r-Gyr codon optimized

<400>  656
tgcctgacac cggacacata cgtggttctc ggggacgggc ggattgagac tattgaggac       60

atcgtgaatg ctaaggagcg caacgtgctc tccctggacc tcgataacct cagcatcaag      120

attgacacgg cgatcaagtt ctggaagctg cgctacaacg gcaatctgag caagatcaca      180

ctctcgaaca attacgagct caaggctact ccggaccact gcctcctggt gctgagggat      240

aaccagctca agtggatccc cgccaaggac attaaggaga acgattacat cgcgatgccg      300

ttcaattaca aggtcgagcg gaagcccatc tccctcctga acctcctgaa gtacctggac      360

atcacagatg ttctcattga gttcgacgag aactccacta tcttcgagaa gattgccgag      420

tacatccgca acaatattaa gacctcaacg aagtacaagt acctcaggaa ccgcagggtc      480

ccgctgaagt acctcatcga gtggaatttc gacctggatg agattgagaa ggaggctaag      540

tacatctaca agtccgttgc cgggaccaag aagatccccc tgttcaagct cgacgagagg      600

ttctggtact tcgctggcct ggtcctcggc gacgggtcga tccaggattc taagatccgg      660

attgcccaga ccccactgaa ggacgtgaag agcattctcg atgagacgtt ccctttcctg      720

cacaactgga tctcgggcaa tcaggtcatc atttctaacc caatcattgc cgagatcctg      780

gagaagctcg gcatgaggaa cgggaagctc aatggcatca ttttctcact gcctgagtcc      840

tacatcaacg ccctcattgc ggggtacttc gacaccgatg gctgcttctc gctcctgtac      900

gacaagaagg cgaagaagca caacctgcgc atggtcctca cgtcaaagcg gcgcgatgtt      960

ctggagaaga tcgggatcta cctcaactcc atcggcattc tgaatacact ccataagtct     1020

agggaggtgt actcactcat catttccaac aagagcctgg agactttcaa ggagaagatc     1080

gcgaagtacc tgaagattcg gaaggaggct ttcatcaacg gctacaagac atacaagaag     1140

gagcatgagg agcgcttcga gtgcgacctc ctgccagtta aggaggtgtt caagaagctc     1200

accttcgaga agggccggaa ggagatcctg aaggactcca agatccacat tgagaactgg     1260

tacaaggaga agaccaacaa tatcccgagg gagaagctga agacggttct ccggtacgcg     1320

aacaatagcg agcataagga gttcctggag aagatcgtga acggggacat ttcgttcgtg     1380

cgcgtcaaga aggtggagaa tatcccgtac gatggctacg tctacgatct ctctatcaag     1440

cataatcaga acttcatctc taatggggtc atttcacaca ac                        1482


<210>  657
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct MP-Be_gp51 codon optimized

<400>  657
tgctcgtgga caaacgctag ggcggttaca aggcgggggt tcgtgcatgt ggatgatctc       60

actactgatg atgaggtcat gtcggtcgac gatcagggca ggacaatctg gcagcagatt      120

gacgaggtgg tccggttccc gttcagcggc acgctctact cgctgggcgg gagggagatc      180

aacgctacca ttacggccaa tcaccgggtt gtgggcctca accgcgagaa gaccaagtgg      240

gttgagcata caccaacttc cctgcctggc aacaagatgt gggtgtacac cgctggcgag      300

gggagcaatg aggactaccc gctcaccgat acggagatca ggctcgctgt gtggggcctg      360

acagactcgc acaggtctcc cgatggccgg tggactttct accagtccgg ggagaaggcg      420

gagcaggtca ggaagctcct ggctgacgct ggcattgagt acagggagag ggctaggaac      480

aggggcatca ccgagattga tgggaaggtc ctcaaggcgc cgcccaagac gcagtacgag      540

ttctcgctcg gcaaggttca ggagctggac gatctcctgg acagggggag gagcgagctg      600

ccaacatgga ctctctccct gagccagagg caggctaggc tcttcctgga ggagtacagg      660

ttcaccgacg gcacggatac cacgtcagct ggggactcct acgtcctcta cgtttgcaag      720

gatcgcatga gggagcagct ccagatgctg gctgctgcta acggcctcag ggcttccaca      780

actgagtaca ggccagggca ttggaggctg aacatctcta atagggcgct ctcaggcctg      840

tacaagaata ccgtggagga ggtcgcttac gagggggaag tgtggtgcct gcgggttcca      900

aatggcaggt tcttcattga ggatgggggc aagattcatc tcacgggcaa c               951


<210>  658
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Nsp-PCC7120_RIR1 codon optimized

<400>  658
tgcctccctg aggatgcgct ggttcatacc gctaaggggc tggtccctat tcgggatgtt       60

caggtcgggg atctcgttca gacaccgctc ggcttccgca gggtggtcga caagttcgat      120

cagggcttcc aggacgtgta cgagatcgag actaacgcga cctacccacg cgctacgctc      180

aatcacaggc aggctgtcct ggaggacgct aagggcggga tcgtttggaa gcatattgct      240

tcgctggagg ccggcgatag gctcctgcac aacaagcagg tcctcccggg cactgttacc      300

catctgcccg cggacttcac tgagagcagg ccatcacact cccggaccgc caagtcgttc      360

gttgtgcctg agctcacggc tgaggtggct tggctgatcg gcttcacaca tggcgacggc      420

tacgtggctc tcggcaggaa caagtacgat aagccgtacg ggcgggttga gtggtccatg      480

aactccctgg acgctgaggt cacctcccgc atccaggcta agattgatgc tgctctcgct      540

ctgttcggcc tctccgctgt ccacagcatc acgaagggcg agaacacagc taagagcatc      600

tgctccagca ttcggctggc cgagtacttc caccgccata tcaagcagcc aaatattcct      660

ctcactgtgc cgtcattcat cctgcagggc tccgtcgaca ttagggctgc ttacctcgct      720

ggcctgatgg actccgatgg ggctgtgaac aataggccac cacacctcat cacatcggtg      780

taccggtctt tcattcgcca ggtctcggtc gttctctcgt ctctgggcat cgccgggagg      840

ctgaccacga cataccccca gaactctaat tggcaggtca agtacaacct cacgatcccg      900

gcgctgaagg agcgctacaa tgctctcatt tctccccatt cagccaaggg cgagctcagg      960

caggggctga agatgtacgg cttcacggtt ccaggggccg tgatgcggga gacgtacaca     1020

tactctgaga tgagggagat gggcttccag gggtcacgga cagttgacgc caactacgag     1080

cgctacgtgg cggaggctga catctccctc gatattcctg tgactgtcaa gggcctgggg     1140

agctacgatc acgtgcagac ctacgacatt gaggttgatg aggctcattg cttctactgc     1200

gatggctacc tcacacataa t                                               1221


<210>  659
<211>  1146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Pab_RIR1-3 codon optimized

<400>  659
tgcgtggtcg gggagacaag gattctgacg cctgagggct acatcaaggc tgaggagctg       60

ttcaagctcg ccaaggagcg gggcaagatg gaggccatcg ctgtggaggg cattgctgag      120

ggcggggagc catacgcgta ctctctggag atcctcctgc ctggcgacaa gcaggtcaag      180

tacgagaccg ttcacgggaa cgctgtggag gtcgccgatc cggtttcagt gcccgcctac      240

gtgtggaagg tcggcatgaa ggaggttgcc cgcgtgagga caaaggaggg ctacgagatc      300

accgccacgc tcgaccataa gctgatgact ccggagggct ggaaggagat caaggacctg      360

aagccagggg ataagattct cctgcctagg ttcgaggtgg aggaggactt cggctccgag      420

agcatcgggg aggatctcgc gttcgtcctg ggctggttca ttggcgacgg gtacctcaac      480

gttaaggata agcgggcgtg gttctacttc aatgctgaga aggaggagga gatcgcctgg      540

aagatccgcg agattctggc taagaggttc gagatcaagg ccgagccaca ccgctacggc      600

aaccagatta agctcggcgt cagggggaag gcgtacgagt ggctggagtc catcgttaag      660

accaacgaga agaggatccc ggagattgtg taccggctca agcccaatga gattgcctca      720

ttcctcaggg gcctgttctc cgctgacggc tacgtggaca atgatatggc tatccgcctc      780

acgtcgaagt ctcgggagct cctgcgcgag gtccaggatc tcctgctcct gttcggcatc      840

ctgtccaaga tctacgagag gccgtacaag cgggagttca agtacaccac gaaggacggc      900

gaggagcgca catacacaac tgaggggtac tacgagctcg tgatcgcgaa ctactcccgg      960

aagatcttcg ctgagcgcat tggcctggag gggtacaaga tggagaagct cagcctggag     1020

aagatcaagg tcgacgagcc cattgtcacc gttgagtcgg tggagatcct cggcaagaag     1080

ctggtctacg acttcactgt tccagagcat cacatgtaca tttccaatgg gttcatgagc     1140

cacaac                                                                1146


<210>  660
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Pfu_KlbA codon optimized

<400>  660
gctctctacg atttctcggt tattcagctc tctaatgggc ggttcgttct catcggggat       60

ctcgtggagg agctgttcaa gaagtacgcc gagaagatca agacctacaa ggacctggag      120

tacattgagc tgaacgagga ggataggttc gaggtggtct cagtctcccc ggacctcaag      180

gcgaataagc acgttgtgtc tcgggtgtgg aggaggaagg tccgcgaggg ggagaagctg      240

atccgcatta agaccaggac gggcaacgag atcattctca cacgcaatca tcccctgttc      300

gccttcagca acggggatgt cgttaggaag gaggctgaga agctcaaagt gggcgacagg      360

gttgccgtga tgatgcggcc gccctcacca cctcagacta aggcggtggt cgacccagct      420

atctacgtta agatttccga ttactacctg gtgccaaacg gcaaggggat gatcaaggtc      480

cctaatgacg gcattccgcc cgagaaggcc cagtacctcc tgtctgtgaa ctcatacccc      540

gttaagctcg tgagggaggt cgatgagaag ctcagctacc tggctggggt catcctgggc      600

gacgggtaca tttccagcaa tggctactac atctcggcga ccttcgacga tgaggcgtac      660

atggacgctt tcgtctccgt tgtgagcgat ttcatcccaa actacgtgcc ttccattagg      720

aagaatgggg actacacaat cgtcactgtt ggctctaaga ttttcgccga gatgctctca      780

cggatcttcg gcattccgcg cgggaggaag tccatgtggg acatccccga tgtcgttctc      840

agcaacgacg atctgatgcg ctacttcatc gccggcctct tcgacgcgga tggctacgtg      900

gacgagaatg gcccgagcat cgtgctggtc accaagtcgg agacggtcgc caggaagatc      960

tggtatgtgc tccagcggct gggcatcatt tcgacggttt ctcgggtgaa gtcgcgcggc     1020

ttcaaggagg gggagctctt ccgggttatc atttctggcg tggaggatct cgctaagttc     1080

gccaagttca tcccactgag gcactcccgg aagcgcgcta agctcatgga gatcctgcgc     1140

acaaagaagc cttacagggg caggcgcact tacagggtcc caatctcgtc tgacatgatt     1200

gctccactga ggcagatgct cgggctgacc gtggctgagc tctcaaagct ggcctcctac     1260

tacgcgggcg agaaggtcag cgagtcgctc atccgccata ttgagaaggg gagggtgaag     1320

gagatcagga ggtcgacgct gaagggcatc gctctcgctc tgcagcagat tgctaaggat     1380

gtgggcaacg aggaggcttg ggtcagggct aagaggctcc agctgatcgc tgagggcgac     1440

gtctactggg atgaggtggt cagcgtcgag gaggttgacc cgaaggagct gggcatcgag     1500

tatgtgtacg atctcacagt ggaggatgat cataactacg ttgctaatgg cattctcgtt     1560

tctaat                                                                1566


<210>  661
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Pho_IF2 codon optimized

<400>  661
tgcctgctgc cggaggagcg ggttattctg cctgactacg ggcctattac tctggaggag       60

ctcttcaata tgacaaagga gacagtgttc aaggacgagg agaaggaggt ccggaagctc      120

ggcatccgca tgccagtggc tggcgtcgat gggcgggtgc gcctgctgga gggcccctac      180

gtttggaagg tgcgctacaa ggggaagatg ctcagggtca agctgaagga ctggcacagc      240

gtggctgtca caccagagca tcccttcctc accacgcggg gctgggtgcg cgctgaccag      300

ctgaagcccg gggattacgt tgccgtgcca aagatcctcc ctgggaagga cgataaggag      360

aagttcctcc agtatgtgca cgagaagctg aagggcaagg ttcatattaa gctgccgtcc      420

agcgacgagg agtgggagac attcttctac ttcgccggca ctatcttcgg gcgcgagaac      480

tcggtgaatc cagagggcct cacccacgag gtcaaggctc tcctggagct cttcaaggtt      540

ctgttcgagt acccgaggga ggtcctccgg gttctgttca tggccccggt gcgctacgtg      600

gcgaacttcc tccgcggctt cttcgacatt aacggctacg tcaatgggga ggagctgagg      660

gtcgaggtta ggggggctcc acatgaggtt ctggaggagc tctccctgat cctcctgagg      720

ctgggcatcg tgtccaagat ctaccctacg agcctggcta tttcgggcag gaggaacctg      780

gagctgttcc ggcgctacat cgggttctcg gagaagcaga aggccaagga gctggagggc      840

atcattaggc ggtctgagaa ctcagagtcc tacccaattt tcgaggagct gcgcaggatc      900

aggctcctgt tcggcttcac ccgggcggag ctctcgtcta cgatcccact gtactctaag      960

tacgagtcaa aggaggctcc ttcatacgag atcctcatga agattctgaa tacaatcgag     1020

aaggggtcta aggacctcaa caagaagatc actattctgg agggcagggt gcgggatcac     1080

gagtacattg aggagttcaa gcgcgagggc ctgatcaagg acgggaagct caccgagctg     1140

ggcaaggagc tcctggaggt ctggcgcaac agggagttcg actccaggga tgtcaactac     1200

ctccggaata tcattgagaa cttcgttttc ctgccggtgg agaagatcga ggagttcgag     1260

tacgatggct acgtctacga cgttactaca gagactcata atttcattgc taatggcatc     1320

ctcgttcata at                                                         1332


<210>  662
<211>  1230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Pho_r-Gyr codon optimized

<400>  662
tgcgttaccc cagacacgct ggtttcgctc tcggacgggc ggattattga gatcagggag       60

gcggtggaga actcggagga gtcgctgctc gggatcaacg gcctgaagcc gaaggaggcc      120

aaggcgctca agttctggga gatcgactgg gatgggccga tcaaggtcat caagctgaag      180

aatggccacg agatcaaggc taccccagac catgggctcc tggttatgag ggatgggaag      240

atcggctggg tgtcggctaa gaacattcgg gagggcgact acgtcgcctt catctacaat      300

ctcgggcacc gcggcgggaa gaagtacacg ctcccccagc tcctgaagga gctgggcatc      360

tccgagtacg agaactccag ctcgcaggag ctcaacaatc gcgagcagga gatggactcc      420

aagcagatca gcattgagct ggatgagagg ttctggtaca tcttcggcgt gattctcggc      480

aaggggaccc tgaaggggga caaggtggtc atcttccaga aggatgtcaa gccggttatt      540

gaggaggcgc tgcccttcgt ccggatcttc gagtcggctg accacatcgg cttctctcat      600

ctcattctgg ctgaggtctt ccgcaggctc ggcgttgggg agggcaagct ccactccctg      660

gtgttcggcc tgagggagga gtacatcaac gctatgattg ccgggtactt cgacgctagc      720

ggcaccttcc tcaggagggc tgtcctgacg agcaagcgcg gcgatatcct caggatgctg      780

tcggtgtacc tctaccagat cggcattgtc aacaatctga ggagggacga gcatgctggc      840

gtgtgggagc tcatcatttc tgatctggag aagttccgcg agaagatcta cccttacctc      900

aggattaaga agtcacagtt cgacaaggtc tactctattt caaagaacga gggcgatttc      960

ctcccggttg cgtctatctt ccggaagctg aagttccgcg acggcttcaa gaatcggatc     1020

ctcgacgagg agattccacg cgatgaggtg gcgaaggtcc tggagtacgc tgaggactca     1080

cctgagaagg agttcctcaa ctccctggtt gaggccaggg tgacatgggt tcgggtggag     1140

aagatcgagg agaggcatta cactggcaag ctctacgact tcacaactac tacagagaac     1200

ttcatttcca atggcatcgt ctcacacaac                                      1230


<210>  663
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Pno_RPA2 codon optimized

<400>  663
tgcctctctg cggatcatga ggttctcaca tctacagggt ggaaggctct ccccgctatt       60

aaggatgcgg atcaggttat gacgctggac ctccagacgg gcacacagca gtggaactcg      120

gtgcaggcta ccacgaggtt cgcgcgggag ggctcactct acaggctgaa gtccgacgat      180

atggatgcgg tctgcaacga gtctcaccgc tggtacctca atactaagga ccagccaaca      240

acttacaccg ctttcaccac gcagcagatg ctggataacc agctcgtggc tctgcgcaac      300

tcctccggca aggctacgga ccagtggaac cacgagtccg ggacaactac ccacacgaac      360

cataatatcc ctacagtcgg ccataacggg aatgttatgt tcagctggcc agactgccca      420

tggctcccac gcgagttcgt cgctgatgag gcgtgcaacc tcgactggtg caggttcatc      480

ggcctcgtga tgggcgacgg gtcgattgat catgtcacgg acgctcaggg ccaggagcac      540

tacagcatcc agattcatca gagggctggg aacccagctt cgaacgctaa tacagaggat      600

gtcctggaga ggctggctgc taagctgcca aatttcgtgg tccacccatc ctgcgttagc      660

ggcgcggagg agaagcatac ttggaccatc aaccaccggg acatgtacca tttcttcctc      720

cccatgatgc gcggcccaca gtcctacgac cctctggata acgccatgtg caggacctac      780

caggctccag attaccaggc cctctcgcgg tctgacaatg agcctatcat tccagtgcca      840

gctgactgga agaccggcaa ctggtggcac ctgcgcaggt ggatcaatta cccatggctc      900

ttctcgctgg cccagtctca ggcgagggct atgattaagg gcatggctgc cgcgaacggg      960

gattggtcac tctccctgaa ggctaggctg gacaccggcg attctggggt tgtgagggtt     1020

ttcagcaatt cgatccccct catgcacgac atgtcagtgc tgggcctcct ggccgatact     1080

cgcgtgaaca ttggcgtcga ccataagaag gggcagatgc agctccaggt ccctgttacc     1140

atgccggcgc tcctggcttg gtgcatctct ttctcattcg cgaactccga cctggctgtg     1200

gctgctccaa agcctgaggc gtacgataat ccgaggcacg acggcttcgt ttactgcctc     1260

acggtgccca acgggaattt cctggcccgg cgcacagtcg agtacagcga taatgataag     1320

attcaggagg tcattgatgc tgctcagaag cctttcttca caggcaac                  1368


<210>  664
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct SaP-SETP3_Helicase codon optimized

<400>  664
tgcctcaagc gggggacaga ggtcattatg ttcgatggga caactaagaa ggtggaggac       60

gttatcgtgg gggacgttct catggggcca gacagcaccc ctaggaacgt gctctcgctg      120

ggcaggggga gggagatgat gtacgaggtg aagccacgga agggcgagtc ctacacggtc      180

aatgagtcac acatcctctc cctgcgcacc acgacaggca ttgcgaaggg gtcctggcct      240

gacaacacag tcttcgatat cagcgttcgg gactggctca agctgccaaa gtatgtgact      300

ggccctaatg ggtacctcaa gggctggagg gtgccagtcg atttcccaag gaaggagcag      360

gacgaggctc tcctgccacc atacctgatg ggcctctggc tgggcgacgg gacttccagc      420

tcgggcgcta tcacctcggg ggagaatgag aaggagatta gggcttacct ggagtcttac      480

gctgctagga acggcatgca gatcaggaag gaggggctga cttggtctat ttcacacggc      540

aacaccgggc acaagaagca tggcttcacg catgcgctca agagcgctgg ggtgctgaac      600

aataagcaca tcccgcataa ctacaagtgc ggcgatagga ggcagaggct ggagctcctg      660

gctggcctcc tggactctga tgggtactgc gatctctcaa aggctggctt cgactggatt      720

tccgttagcg agaggctggc cgacgatttc tgctacctct gccggtcgct gggcttcgct      780

gcctacaaga agaagacctg caagcgctgc gcgaacacag acgtctgggg cgattacttc      840

agggtttcgg tgtctgggga cttctccgag gtgccattcg tcaggggcag gcatcagaat      900

ctccccaagc gcaacatcaa taagaacgtt ctgaacgtgg gcatcgagtc cattaccccc      960

gtcggcgttg acgattactt cgggttcaca attgatgggg attcaaggtt cctcctcggg     1020

gatttcacag ttactcataa tacc                                            1044


<210>  665
<211>  1260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct StP-Twort_ORF6 codon optimized

<400>  665
tgcatttcta tggactctat gattctgaca actgagggct acaagtcgct gcaggagatt       60

ttcgagacac agggggttaa ggtggacaac aaggagaagg ttatcgagct gaagtacccg      120

ctcattaatc ggtacggcga cgtggagtac acctcccact tcacgaagaa cggggagaag      180

ccaacaaagc gcatcaagac taataagggc attgagctgg ttaacacata caatcatcct      240

ctcctggtga gggaggggtt caacctgatc tggaagaaga gcgaggacat cgaagtgggc      300

gatattctcg tgtcccgcgt gggcgaccac cagttcggga acaataacac tgtggagaac      360

gaggaggagg cttacgctct gggctgcatg gtcgcggatt cttacctggg gtcatactcc      420

cggctcagct tctcgaacga caagaaggag atcctcgata aggtctcaaa gttctggaac      480

accttctcca ataaggaggt ttactacgac acctacaagg agtccaaggg gatcacgatt      540

cacctgcatg acacaaacaa gactaaggag ttccatgata agtacaagat cgagtacggc      600

gtcgctaagg acaagaagat cccgaagtgc attatggaga gccccgagaa catccagctg      660

gccttcgtct cgggctacct ggagtgcgag tccagcatct ctgagaagaa cctggaggtt      720

acctctgctt caaaggacct cctgaaggat ctccagctga tcctctcgaa catcggcatt      780

gtgtctacga ataaggagaa ggtggtcaag aagtacaagc acaacaagta ctaccggctg      840

atcgtcaatc gcaaggagct cattaagctc ctgccgctcc tgaggttcga gacgcagcag      900

cggaagaacc agaaggagaa tttcctcagc aataacacaa agatcaagtc gtcttacggc      960

aacactattg aggggtcacg ctacctcctg aagaagtaca gggactccct gaatatcgat     1020

aagaaggagt tctccaagta cctcagccgg gacaccatca cgattgatcg cctgagggag     1080

gtcatctcgc tctacccgga cggcgataag gagattcgcg agctgttcga gaacgttgtg     1140

aataacaata tctactacca gaaggtggag caggtcctgg agggcgagat cattcccacc     1200

ttcgacgttt gcatgcctaa gactcattcc ttcatcgcca acacaatcgt caaccacaac     1260


<210>  666
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Ter_DnaE-2 codon optimized

<400>  666
tgcctctcgg ggtctacaaa ggtcattgac gctgctacgg ggaatctctt ctcgctcaag       60

gagatcgccg ctcagcctga gtactggctc tcgcgcaagg tcttctctct cgacctgaag      120

tcacagcagg tggtccagca gccaatcacc gagattcacc ctaatggcgt gagggatgtc      180

tggcagatca ccacgaggac caacaggaag gtgtgcgcta cggacgatca tctcttctac      240

acagtcctgg gctggaagcc gctcaaggac ttcagcgttg gcgatcgcct cgggctgccg      300

aataagatcc ccattaacta caggtcccag atctccgaca gcaaggtgaa gttcacggcg      360

tacctcattg gcgaggggta cctgtacaca aattcgttct cttgctcata cttctgcaac      420

tccgacgggg agctcatcgc ggatttctac ggctgcgctg aggagctgtt cgggtccagc      480

gctccaatcg agaagcagct ccacctgggc aataagtccg tgatctacgt gcggatcggc      540

ctcatttccg ggctgaagaa ctgggtcgac tcctacctcc agtgcgcgaa tagccgcgtg      600

caggagatcc ccaactggat tttctccctc agccagtcgc agctccagct gttcctcggc      660

atcctgtggt ctacgtcagg gatcttcgac gagacaattg gctacactta ctactcgtct      720

aacagcgagg tcctggttag gcaggtccag catctgttcc tccggctggg catcgtttcc      780

ctcttcaacg tcaataaggt taagggccag ggggagctgg acgtgtccta cgttgtggag      840

gtccgcggga gggaggatat gctgaagttc tacaagctca tcaagccgta cctgtcatcc      900

tacaagcagg gcctctgcga gagctgctac ctggtcatta agtaccagca gtcgtaccag      960

ttcaagtact tcctcactcc cgacttcttc gatctgatcg tgaaggctaa gaaggccagc     1020

tcgatgacca gggctctcgg cgtttgcggc ggggagatct cttcagtgtg gaacttccag     1080

aatacatcta accggtccct gagcttcgac aagttcaaca atttctcgac tgtcctcgcg     1140

gatgaggagc tgaccgccat cgcgaactcg gacgtgttct gggatgagat catttctatc     1200

gagtacattg gcaaggagga ggtgttcgat ctcactattc cagagactca taacttcatt     1260

gctaatgact tcatcgtgca taat                                            1284


<210>  667
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Ter_RIR1-3 codon optimized

<400>  667
tgcgtttcgg gggatacgct gctgattaca agggactcta ttcataagat taaggatgtc       60

gtggggcaga agattgagat ttggaatggc aagaactggt ctcaggtcat cccgctgaag      120

acagggaagg acaggaagct ctaccgggtt cgcttcggcg acgggtcgta cctggatgtt      180

accgagtacc accgcttctt cgtgaaggac aggttcggca agaagtacga ggaggtgcag      240

accaaggatc tcctgacgca ctccaagtac gccctggacg tcgagccatt catcattgat      300

taccatgacg gcgattcgat caacctctct tacgcttaca cactgggggc tgctctcggc      360

aatgggacta tcgaccagaa ctctaatggc aagattaggg tgtactcaca taaggccgag      420

ctgatcttcg cgggcaacaa gtccctggag cggcagtaca attacctccc gagcttcgtg      480

gacgtcattg atctcggctt ctcgggggag ctcctgagga ggctgcagac cgagcccgac      540

gctctcaaca cgatcgcctc atggaataag tccgctatcc tggccttcat tgcgggcctc      600

gctgacacag atgggagcga gactaagggc aacgggatca agatttccgt gagcgactac      660

gagagggcca agcggctgca gctcctgctc acgaagtgcg gcattagggc gagcgtcaat      720

ctgatggctt cgcggggctg caccacgaac ctcggggagc gcaatcagga cctgtactac      780

ctccagatca ccgattgccg ggagattcca tgccagcgcc tcgacacaac taaggtttgc      840

gaggcgaagt tccagggcaa gtaccagacc atccagaacg tcgaggagct gcctggcctc      900

cacgatacgt actgcttcga ggagccagag ttccacaagg gggttttcgg caatgctctc      960

acaggcaac                                                              969


<210>  668
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tko_Helicase codon optimized

<400>  668
tgcatgcatc ctgacacata cgtggttact aagtcggggg ctaagaaggt ctctgagctg       60

actgaggggg atgaggtcct gacacatacc ggcacgttca agaaggtcat ccagccactg      120

aggagggagc acaaggggcg cctcctggtt atcaaggcct acggcaccgt gcctgtcaag      180

attacgccgg agcacatggt ttgggtggtc aagcagatca ggcacaagtc ccattacagc      240

gatgggcggc aggtcatttg gtgggagttc gagggcccag agtggatgac ggctcaggag      300

ctgaaggagc gcctggagtc cgagacagac ccaaaggtga gctacatgct cctgcagcca      360

atccctgagc cgtccgtgga cgcggataag attcctctga ggaaggaggt ctacgttgtg      420

aaccagcacg gcaagacaga caagctccat ccgtccgtga agcggactcc cgagtacctg      480

ccactcaact tcgagaccgc taggctgatc ggcctctgga ttgctgaggg gtcaacttcc      540

aagaacggcg tcatcaagtt cgacatttcc agcaatgagg aggatctgac ggagttcatc      600

acaggcacta ttaggaagta cttcccgcac gctaagatcg tcgttaagga ccatgagagg      660

aacaggagga cggtccggtt ctgcaataag cgcttcgcgg agtggctcag ggagaacatc      720

ggccacgggg ctgataataa gagcattccg cccctcctgc tcctgaacaa gaatagggag      780

gtgcgcctgg gcctcctgag ggggctcatc gagggcgacg gctacgtgcg cagggagtcg      840

cagcgcaggg cgaactacat cagctactcg acagtttctc cctcactggc ttaccagctc      900

cagctcctgg tggcttcgct gggctacacc tcgtctatcc acaggtctat tcggacagag      960

ggcatcggga agactaggaa gcccatctac gatgttaagg tgtcgggcaa gtcttactac     1020

tcactcctgg aggagctcgg gttcgaggtc ccacagaggg gcaacaggac ctacaacgtt     1080

aatcgcacgt ggaagaatta cctcctgctc aaggtgaggt ccatcgagga ggaggagtac     1140

gagggcgacg tttacaatct ggaggttgag ggggatgagt caggctctgt gggcttcatc     1200

gtgcataat                                                             1209


<210>  669
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tko_Pol-2_Pko_Pol-2 codon optimized

<400>  669
tctattctgc ctgaggagtg gctgcctgtt ctggaggagg gggaggttca tttcgttagg       60

atcggggagc tgattgaccg catgatggag gagaacgctg gcaaggtcaa gagggagggg      120

gagaccgagg tcctggaggt ttcaggcctg gaggtgccgt ccttcaaccg caggacgaat      180

aaggcggagc tgaagagggt caaggctctc atccggcacg actactctgg caaggtgtac      240

accattaggc tgaagtcagg ccggcgcatc aagattacgt cagggcattc cctgttcagc      300

gtccggaacg gcgagctcgt tgaggtgacc ggcgacgagc tgaagccagg ggatctcgtc      360

gctgttccaa ggaggctgga gctgccagag aggaaccacg tcctcaatct ggttgagctc      420

ctgctcggca caccggagga ggagactctg gacatcgtga tgacgattcc cgtcaagggc      480

aagaagaact tcttcaaggg gatgctcagg acactgcggt ggatcttcgg cgaggagaag      540

aggccaagga ctgctcgcag gtacctcagg catctggagg acctcggcta cgtgcggctc      600

aagaagatcg ggtacgaggt cctggactgg gatagcctca agaattaccg gcgcctgtac      660

gaggctctcg tggagaacgt ccgctacaac ggcaataaga gggagtacct ggttgagttc      720

aattcgatcc gcgacgccgt ggggattatg ccgctgaagg agctcaagga gtggaagatc      780

ggcacactca acgggttccg gatgcgcaag ctgattgagg tcgatgagtc cctcgccaag      840

ctgctcggct actacgtgag cgaggggtac gcgcgcaagc agaggaaccc gaagaatggc      900

tggtcgtact ctgtcaagct gtacaatgag gaccccgagg ttctggacga tatggagcgg      960

ctcgcgagcc gcttcttcgg caaggttagg cgggggagga actacgtgga gatccccaag     1020

aagattggct acctgctctt cgagaatatg tgcggggtgc tcgctgagaa caagcgcatc     1080

ccagagttcg tcttcacatc acctaagggc gttaggctgg ccttcctgga ggggtactcc     1140

agcgctatgg ctacctccac ggagcaggag actcaggcgc tgaacgagaa gcgcgctctg     1200

gccaatcagc tcgttctgct cctgaactcg gtgggcgtct ctgctgtgaa gctcggccac     1260

gactccgggg tttacagggt gtacatcaat gaggagctgc cattcgtcaa gctcgataag     1320

aagaagaacg cttactacag ccatgtgatt cctaaggagg tcctctcgga ggtcttcggc     1380

aaggttttcc agaagaacgt gtccccacag accttccgga agatggtcga ggacggcagg     1440

ctggatcctg agaaggctca gaggctgtcg tggctcatcg agggggacgt ggtcctcgat     1500

cgcgtcgagt ctgttgacgt ggaggactac gatggctacg tgtacgatct ctctgtggag     1560

gataatgaga acttcctcgt gggcttcggg ctcgtttacg ctcataat                  1608


<210>  670
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tvo_VMA codon optimized

<400>  670
tgcgtttcgg gggagacgcc agtctacctc gctgacggca agacaattaa gatcaaggac       60

ctctactcat ctgagcgcaa gaaggaggac aacatcgtcg aggctggctc cggggaggag      120

atcattcacc tcaaggaccc gatccagatc tacagctacg ttgatggcac gatcgtgcgc      180

tcccgctccc gcctcctgta caaggggaag tccagctacc tggtgcgcat cgagacaatt      240

ggcgggcgct cagtgtccgt cactcccgtc cataagctct tcgttctgac cgagaagggc      300

atcgaggagg ttatggcctc gaatctcaaa gtgggggaca tgattgctgc tgtcgctgag      360

agcgagtcgg aggcccggga ttgcggcatg agcgaggagt gcgtgatgga ggcggaggtc      420

tacacctctc tggaggctac gttcgaccgc gttaagtcaa tcgcgtacga gaagggcgac      480

ttcgatgtgt acgatctgtc agttccagag tacggcagga acttcattgg gggggagggg      540

ctgctcgtgc tccacaac                                                    558


<210>  671
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Tvu_DnaE-n_NC-terminal codon optimized

<400>  671
tgcctctcag gggagactgc ggttatgacg gtggagtacg gggctattcc tattcggcgg       60

ctggttcagg agcggctgat ctgccaggtt tactcgctcg acccacaggg ccacctgtac      120

acgcagccta tcgctcagtg gcatttccag ggcttccgcc cggtgtacgc gtaccagctg      180

gaggacgggt ccacaatttg cgctactccg gatcaccggt tcatgaccac gagcggccag      240

atgctgccca tcgagcagat tttccgcgag gggctggagc tgtggcaggt ggccatcgct      300

ccaccaggcg ctctcgctca ggggctgaag ccggccgtcc agatgtcctg catgaagatt      360

gtgggcagga ggctcgtcgg gtggcaggct gtttacgata ttgggctcgc cggggatcat      420

aacttcctcc tcgctaatgg ggctattgct gctaat                                456


<210>  672
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Unc-ERS_RIR1 codon optimized

<400>  672
tgcgttaccg ctgacacatg ggttactacc gctgaggggc caaggcaggt ggaggagctg       60

atcggcaaga agttcacggc tatcgttaac ggcgaggagt gggagtccag cgaggagggg      120

ttcttcgaga cagacgttaa gccagtgtac accctgaaga cggctgaggg cttcgagctg      180

aggctcacgg ctgatcaccc tgtcatgaag gttgagagga tgacacggta caaggtggag      240

actcagtggt ccaacgctgg cgacctcaag ccaggggata agatcattat caacaatcat      300

agggacttcg gcaattggag cgtcaagggg aagtacaccg agggcgaggg gtacctgatt      360

ggcctcctgc tcggcgacgg gacgatcaag aagctcaacc cctggatgaa ggcgatttca      420

aagaagatgg agaaggcctc cgcggatttc tgcgagggca tcctgagggg gctcttcgac      480

gctgatggct ctgtgcaggg gaatcagtcg aagggcgtct ctattcgcct ggcccagtca      540

gacgtcgaga tcctcaaggc ggttcagcgc attctgctca ggttcggcat cttctcgaag      600

gtgtacatga accgcagggg cgagcggaag gttaagatgc cggatgggaa gggcggggtc      660

aaggagtaca tcaccaagcc ccagcacgag ctcgtgatca gcaacgacaa tatcctctac      720

ttcgctgaga gggtcggctt ctcggatgcc gagaagatgg agaagctgga gaaggctatc      780

tggaactaca agcggaagat gaatagggag aggttcgtgg ctagcgtcga ggaggtggtc      840

ccagacggcg ttgagaaggt gtacgacgtt aagattccag gcatcaatgc tttcaatgct      900

aatggcttcg tggttcacaa c                                                921


<210>  673
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct Unc-ERS_RIR1_var7

<400>  673
tgcgttaccg ctgacacatg ggttactacc gctgaggggc caaggcaggt ggaggagttg       60

atcggcaaga agttcacggc tatcgttaac ggcgaggagt gggagtccag cgaggagggg      120

ttcttcgaga cagacgttaa gccagtgtac accctgaaga cggctgaggg cttcgagctg      180

aggctcacgg ctgatcaccc tgtcatgaag gttgagagga tgacacggta caaggtggag      240

actcagtggt ccaacgctgg cgacctcaag ccaggggata agatcattat caacaatcat      300

agggacttcg gcaattggag cgtcaagggg aagtacaccg agggcgaggg gtacctgatt      360

ggcctcctgc tcggcgacgg gacgatcaag aagctcaacc cctggatgaa ggcgatttca      420

aagaagatgg agaaggcctc cgcagatttc tgcgagggca tcctgagggg gctctccgac      480

gctgatggct ctgtgcaggg gaatcagtcg aagggcgtct ctattcgcct ggcccagtca      540

gacgtcgaga tcctcaaggc ggttcagcgc attctgctca ggttcggcat cttctcgaag      600

gtgtacatga accgcagggg cgagcggaag gttaagatgc cggatgggaa gggcggggtc      660

aaggagtaca tcaccaagcc ccagcacgag ctcgtgatca gcaacgacaa tatcctctac      720

ttcgctgaga gggtcggctt ctcggatgcc gagaagatgg agaagctgga gaaggctatc      780

tggaactaca agcggaagat gaatagggag aggttcgtgg ctagcgtcga ggaggtggtc      840

ccagacggcg ttgagaaggt gtacgacgtt aagattccag gcatcaatgc tttcaatgct      900

aatggcttcg tggttcacaa c                                                921


<210>  674
<211>  264
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct gp41-1-N codon optimized

<400>  674
tgtctggacc tgaaaacgca agtgcaaacc ccgcaaggca tgaaggaaat ctcaaacatc       60

caagtcggtg acctggtgct gtcgaatacc ggctataacg aagtgctgaa tgtttttccg      120

aagagcaaaa agaaatctta caagatcacg ctggaagatg gcaaggaaat tatttgcagc      180

gaagaacatc tgttcccgac ccagacgggc gaaatgaata tctccggcgg tctgaaagaa      240

ggcatgtgtc tgtacgtcaa ggaa                                             264


<210>  675
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct gp41-1-C codon optimized

<400>  675
atgatgctga agaaaattct gaagatcgaa gaactggatg aacgtgaact gattgacatc       60

gaagttagcg gcaaccatct gttttacgcg aatgacattc tgacccacaa c               111


<210>  676
<211>  273
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct gp41-8-N codon optimized

<400>  676
tgtctgtccc tggatacgat ggttgtgacg aatggcaagg ctattgaaat ccgtgatgtg       60

aaagtgggcg actggctgga aagcgaactg ggcccggtgc aggttaccga agtcctgccg      120

attatcaaac aaccggtttt tgaaattgtc ctgaaaagca agtctggcaa aaagatccgt      180

gtgagcgcaa accataaatt cccgaccaag gatggtctga aaacgattaa tagtggcctg      240

aaggttggtg actttctgcg ttcccgcgcg aaa                                   273


<210>  677
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct gp41-8-C codon optimized

<400>  677
atgtgcgaaa ttttcgaaaa cgaaatcgat tgggacgaaa ttgccagcat cgaatatgtc       60

ggcgtggaag aaaccattga tatcaacgtt acgaatgacc gcctgttttt cgcgaacggt      120

atcctgacgc acaat                                                       135


<210>  678
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct IMPDH-1-N codon optimized

<400>  678
tgctttgtcc cgggcacgct ggtgaatacc gaaaatggtc tgaaaaagat tgaagaaatt       60

aaagtgggcg ataaggtgtt tagtcatacc ggcaaactgc aagaagtggt tgatacgctg      120

atttttgatc gtgacgaaga aattatcagt attaacggta tcgactgcac caagaaccat      180

gaattttacg tgatcgataa ggaaaacgcg aatcgtgtta acgaagacaa tatccatctg      240

ttcgcgcgct gggtccacgc cgaagaactg gatatgaaaa agcacctgct gatcgaactg      300

gaa                                                                    303


<210>  679
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct IMPDH-1-C codon optimized

<400>  679
atgaagttca agctgaagga aatcaccagc atcgaaacga aacattataa gggcaaagtt       60

cacgatctga ccgtcaacca agaccattct tacaatgttc gcggtacggt cgtgcacaac      120


<210>  680
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct NrdJ-1-N codon optimized

<400>  680
tgcctggtcg gtagcagcga aatcatcacg cgcaactatg gtaaaacgac gatcaaggaa       60

gtggtggaaa tctttgacaa cgataaaaac attcaggtcc tggcgtttaa cacccatacg      120

gataatattg aatgggcccc gatcaaagcg gcccaactga cccgtccgaa tgcagaactg      180

gttgaactgg aaattgacac gctgcatggc gtcaaaacca tccgctgcac gccggatcac      240

ccggtctata ccaagaaccg tggttacgtg cgcgctgacg aactgacgga tgacgatgaa      300

ctggtggttg caatt                                                       315


<210>  681
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct NrdJ-1-C codon optimized

<400>  681
atggaagcta aaacctatat cggcaaactg aagagccgta agattgtgtc taacgaagac       60

acctacgata tccagaccag tacgcataac tttttcgcaa atgatatcct ggttcacaat      120


<210>  682
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  proSavinase H62A

<400>  682

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly Ala Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
    290                 295                 300                 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
305                 310                 315                 320 


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
                325                 330                 335     


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
            340                 345                 350         


Thr Arg 
        


<210>  683
<211>  1062
<212>  DNA
<213>  Artificial sequence

<220>
<223>  proSavinase H62A

<400>  683
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacca tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatggggc tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tcaacatatg ccagcttaaa cggtacatcg      900

atggctactc ctcatgttgc aggtgcggcc gcccttgtta aacaaaagaa cccatcttgg      960

tctaatgtac aaattcgaaa tcatctaaag aatacggcaa ctagtttagg aagcacgaac     1020

ttgtatggaa gcggacttgt taacgcagaa gcggcaacgc gt                        1062


<210>  684
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, mVMA:P77cd protein

<400>  684

Cys Phe Ala Lys Gly Thr Asn Val Leu Met Ala Asp Gly Ser Ile Glu 
1               5                   10                  15      


Cys Ile Glu Asn Ile Glu Val Gly Asn Lys Val Met Gly Lys Asp Gly 
            20                  25                  30          


Arg Pro Arg Glu Val Ile Lys Leu Pro Arg Gly Arg Glu Thr Met Tyr 
        35                  40                  45              


Ser Val Val Gln Lys Ser Gln His Arg Ala His Lys Ser Asp Ser Ser 
    50                  55                  60                  


Arg Glu Val Pro Glu Leu Leu Lys Phe Thr Cys Asn Ala Thr His Glu 
65                  70                  75                  80  


Leu Val Val Arg Thr Pro Arg Ser Val Arg Arg Leu Ser Arg Thr Ile 
                85                  90                  95      


Lys Gly Val Glu Tyr Phe Glu Val Ile Thr Phe Glu Met Gly Gln Lys 
            100                 105                 110         


Lys Ala Pro Asp Gly Arg Ile Val Glu Leu Val Lys Glu Val Ser Lys 
        115                 120                 125             


Ser Tyr Pro Ile Ser Glu Gly Pro Glu Arg Ala Asn Glu Leu Val Glu 
    130                 135                 140                 


Ser Tyr Arg Lys Ala Ser Asn Lys Ala Tyr Phe Glu Trp Thr Ile Glu 
145                 150                 155                 160 


Ala Arg Asp Leu Ser Leu Leu Gly Ser His Val Arg Lys Ala Thr Tyr 
                165                 170                 175     


Gln Thr Tyr Ala Pro Gln Thr Ser Ile Thr Leu Thr Ser Asn Ala Ser 
            180                 185                 190         


Gly Thr Phe Asp Gly Tyr Tyr Tyr Glu Leu Trp Lys Asp Thr Gly Asn 
        195                 200                 205             


Thr Thr Met Thr Val Tyr Thr Gln Gly Arg Phe Ser Cys Gln Trp Ser 
    210                 215                 220                 


Asn Ile Asn Asn Ala Leu Phe Arg Thr Gly Lys Lys Tyr Asn Gln Asn 
225                 230                 235                 240 


Trp Gln Ser Leu Gly Thr Ile Arg Ile Thr Tyr Ser Ala Thr Tyr Asn 
                245                 250                 255     


Pro Asn Gly Asn Ser Tyr Leu Cys Ile Tyr Gly Trp Ser Thr Asn Pro 
            260                 265                 270         


Leu Val Glu Phe Tyr Ile Val Glu Ser Trp Gly Asn Trp Arg Pro Pro 
        275                 280                 285             


Gly Ala Thr Ser Leu Gly Gln Val Thr Ile Asp Gly Gly Thr Tyr Asp 
    290                 295                 300                 


Ile Tyr Arg Thr Thr Arg Val Asn Gln Pro Ser Ile Val Gly Thr Ala 
305                 310                 315                 320 


Thr Phe Asp Gln Tyr Trp Ser Val Arg Thr Ser Lys Arg Thr Ser Gly 
                325                 330                 335     


Thr Val Thr Val Thr Asp His Phe Arg Ala Trp Ala Asn Arg Gly Leu 
            340                 345                 350         


Asn Leu Gly Thr Ile Asp Gln Ile Thr Leu Cys Val Glu Gly Tyr Gln 
        355                 360                 365             


Ser Ser Gly Ser Ala Asn Ile Thr Gln Asn Thr Phe Ser Arg Gly Phe 
    370                 375                 380                 


Tyr Phe Glu Leu Gln Glu Leu Lys Glu Asp Asp Tyr Tyr Gly Ile Thr 
385                 390                 395                 400 


Leu Ser Asp Asp Ser Asp His Gln Phe Leu Leu Ala Asn Gln Val Val 
                405                 410                 415     


Val His Asn 
            


<210>  685
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct mTth:P77Cd

<400>  685

Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln Arg 
1               5                   10                  15      


Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu Gly 
            20                  25                  30          


Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu Ser 
        35                  40                  45              


Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu 
    50                  55                  60                  


Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro 
65                  70                  75                  80  


Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Gln Thr Ser Ile 
                85                  90                  95      


Thr Leu Thr Ser Asn Ala Ser Gly Thr Phe Asp Gly Tyr Tyr Tyr Glu 
            100                 105                 110         


Leu Trp Lys Asp Thr Gly Asn Thr Thr Met Thr Val Tyr Thr Gln Gly 
        115                 120                 125             


Arg Phe Ser Cys Gln Trp Ser Asn Ile Asn Asn Ala Leu Phe Arg Thr 
    130                 135                 140                 


Gly Lys Lys Tyr Asn Gln Asn Trp Gln Ser Leu Gly Thr Ile Arg Ile 
145                 150                 155                 160 


Thr Tyr Ser Ala Thr Tyr Asn Pro Asn Gly Asn Ser Tyr Leu Cys Ile 
                165                 170                 175     


Tyr Gly Trp Ser Thr Asn Pro Leu Val Glu Phe Tyr Ile Val Glu Ser 
            180                 185                 190         


Trp Gly Asn Trp Arg Pro Pro Gly Ala Thr Ser Leu Gly Gln Val Thr 
        195                 200                 205             


Ile Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Thr Thr Arg Val Asn Gln 
    210                 215                 220                 


Pro Ser Ile Val Gly Thr Ala Thr Phe Asp Gln Tyr Trp Ser Val Arg 
225                 230                 235                 240 


Thr Ser Lys Arg Thr Ser Gly Thr Val Thr Val Thr Asp His Phe Arg 
                245                 250                 255     


Ala Trp Ala Asn Arg Gly Leu Asn Leu Gly Thr Ile Asp Gln Ile Thr 
            260                 265                 270         


Leu Cys Val Glu Gly Tyr Gln Ser Ser Gly Ser Ala Asn Ile Thr Gln 
        275                 280                 285             


Asn Thr Phe Ser Arg Asp Val Glu Thr Gly Glu Val Leu Trp Asp Pro 
    290                 295                 300                 


Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg 
305                 310                 315                 320 


Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val Val His Asn 
                325                 330                 335     


<210>  686
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS135:mVMA:P77Cd protein

<400>  686

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Cys Phe Ala Lys Gly Thr Asn Val Leu Met 
    130                 135                 140                 


Ala Asp Gly Ser Ile Glu Cys Ile Glu Asn Ile Glu Val Gly Asn Lys 
145                 150                 155                 160 


Val Met Gly Lys Asp Gly Arg Pro Arg Glu Val Ile Lys Leu Pro Arg 
                165                 170                 175     


Gly Arg Glu Thr Met Tyr Ser Val Val Gln Lys Ser Gln His Arg Ala 
            180                 185                 190         


His Lys Ser Asp Ser Ser Arg Glu Val Pro Glu Leu Leu Lys Phe Thr 
        195                 200                 205             


Cys Asn Ala Thr His Glu Leu Val Val Arg Thr Pro Arg Ser Val Arg 
    210                 215                 220                 


Arg Leu Ser Arg Thr Ile Lys Gly Val Glu Tyr Phe Glu Val Ile Thr 
225                 230                 235                 240 


Phe Glu Met Gly Gln Lys Lys Ala Pro Asp Gly Arg Ile Val Glu Leu 
                245                 250                 255     


Val Lys Glu Val Ser Lys Ser Tyr Pro Ile Ser Glu Gly Pro Glu Arg 
            260                 265                 270         


Ala Asn Glu Leu Val Glu Ser Tyr Arg Lys Ala Ser Asn Lys Ala Tyr 
        275                 280                 285             


Phe Glu Trp Thr Ile Glu Ala Arg Asp Leu Ser Leu Leu Gly Ser His 
    290                 295                 300                 


Val Arg Lys Ala Thr Tyr Gln Thr Tyr Ala Pro Gln Thr Ser Ile Thr 
305                 310                 315                 320 


Leu Thr Ser Asn Ala Ser Gly Thr Phe Asp Gly Tyr Tyr Tyr Glu Leu 
                325                 330                 335     


Trp Lys Asp Thr Gly Asn Thr Thr Met Thr Val Tyr Thr Gln Gly Arg 
            340                 345                 350         


Phe Ser Cys Gln Trp Ser Asn Ile Asn Asn Ala Leu Phe Arg Thr Gly 
        355                 360                 365             


Lys Lys Tyr Asn Gln Asn Trp Gln Ser Leu Gly Thr Ile Arg Ile Thr 
    370                 375                 380                 


Tyr Ser Ala Thr Tyr Asn Pro Asn Gly Asn Ser Tyr Leu Cys Ile Tyr 
385                 390                 395                 400 


Gly Trp Ser Thr Asn Pro Leu Val Glu Phe Tyr Ile Val Glu Ser Trp 
                405                 410                 415     


Gly Asn Trp Arg Pro Pro Gly Ala Thr Ser Leu Gly Gln Val Thr Ile 
            420                 425                 430         


Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Thr Thr Arg Val Asn Gln Pro 
        435                 440                 445             


Ser Ile Val Gly Thr Ala Thr Phe Asp Gln Tyr Trp Ser Val Arg Thr 
    450                 455                 460                 


Ser Lys Arg Thr Ser Gly Thr Val Thr Val Thr Asp His Phe Arg Ala 
465                 470                 475                 480 


Trp Ala Asn Arg Gly Leu Asn Leu Gly Thr Ile Asp Gln Ile Thr Leu 
                485                 490                 495     


Cys Val Glu Gly Tyr Gln Ser Ser Gly Ser Ala Asn Ile Thr Gln Asn 
            500                 505                 510         


Thr Phe Ser Arg Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys Glu Asp 
        515                 520                 525             


Asp Tyr Tyr Gly Ile Thr Leu Ser Asp Asp Ser Asp His Gln Phe Leu 
    530                 535                 540                 


Leu Ala Asn Gln Val Val Val His Asn Ser Gly Val Lys Val Ala Val 
545                 550                 555                 560 


Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly 
                565                 570                 575     


Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His 
            580                 585                 590         


Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly 
        595                 600                 605             


Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu 
    610                 615                 620                 


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
625                 630                 635                 640 


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
                645                 650                 655     


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
            660                 665                 670         


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser 
        675                 680                 685             


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
    690                 695                 700                 


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
705                 710                 715                 720 


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
                725                 730                 735     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            740                 745                 750         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        755                 760                 765             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    770                 775                 780                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795                 


<210>  687
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS265:mVMA:P77Cd protein

<400>  687

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Cys Phe Ala Lys Gly Thr Asn Val 
            260                 265                 270         


Leu Met Ala Asp Gly Ser Ile Glu Cys Ile Glu Asn Ile Glu Val Gly 
        275                 280                 285             


Asn Lys Val Met Gly Lys Asp Gly Arg Pro Arg Glu Val Ile Lys Leu 
    290                 295                 300                 


Pro Arg Gly Arg Glu Thr Met Tyr Ser Val Val Gln Lys Ser Gln His 
305                 310                 315                 320 


Arg Ala His Lys Ser Asp Ser Ser Arg Glu Val Pro Glu Leu Leu Lys 
                325                 330                 335     


Phe Thr Cys Asn Ala Thr His Glu Leu Val Val Arg Thr Pro Arg Ser 
            340                 345                 350         


Val Arg Arg Leu Ser Arg Thr Ile Lys Gly Val Glu Tyr Phe Glu Val 
        355                 360                 365             


Ile Thr Phe Glu Met Gly Gln Lys Lys Ala Pro Asp Gly Arg Ile Val 
    370                 375                 380                 


Glu Leu Val Lys Glu Val Ser Lys Ser Tyr Pro Ile Ser Glu Gly Pro 
385                 390                 395                 400 


Glu Arg Ala Asn Glu Leu Val Glu Ser Tyr Arg Lys Ala Ser Asn Lys 
                405                 410                 415     


Ala Tyr Phe Glu Trp Thr Ile Glu Ala Arg Asp Leu Ser Leu Leu Gly 
            420                 425                 430         


Ser His Val Arg Lys Ala Thr Tyr Gln Thr Tyr Ala Pro Gln Thr Ser 
        435                 440                 445             


Ile Thr Leu Thr Ser Asn Ala Ser Gly Thr Phe Asp Gly Tyr Tyr Tyr 
    450                 455                 460                 


Glu Leu Trp Lys Asp Thr Gly Asn Thr Thr Met Thr Val Tyr Thr Gln 
465                 470                 475                 480 


Gly Arg Phe Ser Cys Gln Trp Ser Asn Ile Asn Asn Ala Leu Phe Arg 
                485                 490                 495     


Thr Gly Lys Lys Tyr Asn Gln Asn Trp Gln Ser Leu Gly Thr Ile Arg 
            500                 505                 510         


Ile Thr Tyr Ser Ala Thr Tyr Asn Pro Asn Gly Asn Ser Tyr Leu Cys 
        515                 520                 525             


Ile Tyr Gly Trp Ser Thr Asn Pro Leu Val Glu Phe Tyr Ile Val Glu 
    530                 535                 540                 


Ser Trp Gly Asn Trp Arg Pro Pro Gly Ala Thr Ser Leu Gly Gln Val 
545                 550                 555                 560 


Thr Ile Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Thr Thr Arg Val Asn 
                565                 570                 575     


Gln Pro Ser Ile Val Gly Thr Ala Thr Phe Asp Gln Tyr Trp Ser Val 
            580                 585                 590         


Arg Thr Ser Lys Arg Thr Ser Gly Thr Val Thr Val Thr Asp His Phe 
        595                 600                 605             


Arg Ala Trp Ala Asn Arg Gly Leu Asn Leu Gly Thr Ile Asp Gln Ile 
    610                 615                 620                 


Thr Leu Cys Val Glu Gly Tyr Gln Ser Ser Gly Ser Ala Asn Ile Thr 
625                 630                 635                 640 


Gln Asn Thr Phe Ser Arg Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys 
                645                 650                 655     


Glu Asp Asp Tyr Tyr Gly Ile Thr Leu Ser Asp Asp Ser Asp His Gln 
            660                 665                 670         


Phe Leu Leu Ala Asn Gln Val Val Val His Asn Ser Gly Ala Gly Ser 
        675                 680                 685             


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
    690                 695                 700                 


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
705                 710                 715                 720 


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
                725                 730                 735     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            740                 745                 750         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        755                 760                 765             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    770                 775                 780                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795                 


<210>  688
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS269:mVMA:P77Cd protein

<400>  688

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Cys Phe Ala Lys 
            260                 265                 270         


Gly Thr Asn Val Leu Met Ala Asp Gly Ser Ile Glu Cys Ile Glu Asn 
        275                 280                 285             


Ile Glu Val Gly Asn Lys Val Met Gly Lys Asp Gly Arg Pro Arg Glu 
    290                 295                 300                 


Val Ile Lys Leu Pro Arg Gly Arg Glu Thr Met Tyr Ser Val Val Gln 
305                 310                 315                 320 


Lys Ser Gln His Arg Ala His Lys Ser Asp Ser Ser Arg Glu Val Pro 
                325                 330                 335     


Glu Leu Leu Lys Phe Thr Cys Asn Ala Thr His Glu Leu Val Val Arg 
            340                 345                 350         


Thr Pro Arg Ser Val Arg Arg Leu Ser Arg Thr Ile Lys Gly Val Glu 
        355                 360                 365             


Tyr Phe Glu Val Ile Thr Phe Glu Met Gly Gln Lys Lys Ala Pro Asp 
    370                 375                 380                 


Gly Arg Ile Val Glu Leu Val Lys Glu Val Ser Lys Ser Tyr Pro Ile 
385                 390                 395                 400 


Ser Glu Gly Pro Glu Arg Ala Asn Glu Leu Val Glu Ser Tyr Arg Lys 
                405                 410                 415     


Ala Ser Asn Lys Ala Tyr Phe Glu Trp Thr Ile Glu Ala Arg Asp Leu 
            420                 425                 430         


Ser Leu Leu Gly Ser His Val Arg Lys Ala Thr Tyr Gln Thr Tyr Ala 
        435                 440                 445             


Pro Gln Thr Ser Ile Thr Leu Thr Ser Asn Ala Ser Gly Thr Phe Asp 
    450                 455                 460                 


Gly Tyr Tyr Tyr Glu Leu Trp Lys Asp Thr Gly Asn Thr Thr Met Thr 
465                 470                 475                 480 


Val Tyr Thr Gln Gly Arg Phe Ser Cys Gln Trp Ser Asn Ile Asn Asn 
                485                 490                 495     


Ala Leu Phe Arg Thr Gly Lys Lys Tyr Asn Gln Asn Trp Gln Ser Leu 
            500                 505                 510         


Gly Thr Ile Arg Ile Thr Tyr Ser Ala Thr Tyr Asn Pro Asn Gly Asn 
        515                 520                 525             


Ser Tyr Leu Cys Ile Tyr Gly Trp Ser Thr Asn Pro Leu Val Glu Phe 
    530                 535                 540                 


Tyr Ile Val Glu Ser Trp Gly Asn Trp Arg Pro Pro Gly Ala Thr Ser 
545                 550                 555                 560 


Leu Gly Gln Val Thr Ile Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Thr 
                565                 570                 575     


Thr Arg Val Asn Gln Pro Ser Ile Val Gly Thr Ala Thr Phe Asp Gln 
            580                 585                 590         


Tyr Trp Ser Val Arg Thr Ser Lys Arg Thr Ser Gly Thr Val Thr Val 
        595                 600                 605             


Thr Asp His Phe Arg Ala Trp Ala Asn Arg Gly Leu Asn Leu Gly Thr 
    610                 615                 620                 


Ile Asp Gln Ile Thr Leu Cys Val Glu Gly Tyr Gln Ser Ser Gly Ser 
625                 630                 635                 640 


Ala Asn Ile Thr Gln Asn Thr Phe Ser Arg Gly Phe Tyr Phe Glu Leu 
                645                 650                 655     


Gln Glu Leu Lys Glu Asp Asp Tyr Tyr Gly Ile Thr Leu Ser Asp Asp 
            660                 665                 670         


Ser Asp His Gln Phe Leu Leu Ala Asn Gln Val Val Val His Asn Ser 
        675                 680                 685             


Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr 
    690                 695                 700                 


Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
705                 710                 715                 720 


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
                725                 730                 735     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            740                 745                 750         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        755                 760                 765             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    770                 775                 780                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795                 


<210>  689
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS293:mVMA:P77Cd protein

<400>  689

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            260                 265                 270         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        275                 280                 285             


Asn Asn Arg Ala Cys Phe Ala Lys Gly Thr Asn Val Leu Met Ala Asp 
    290                 295                 300                 


Gly Ser Ile Glu Cys Ile Glu Asn Ile Glu Val Gly Asn Lys Val Met 
305                 310                 315                 320 


Gly Lys Asp Gly Arg Pro Arg Glu Val Ile Lys Leu Pro Arg Gly Arg 
                325                 330                 335     


Glu Thr Met Tyr Ser Val Val Gln Lys Ser Gln His Arg Ala His Lys 
            340                 345                 350         


Ser Asp Ser Ser Arg Glu Val Pro Glu Leu Leu Lys Phe Thr Cys Asn 
        355                 360                 365             


Ala Thr His Glu Leu Val Val Arg Thr Pro Arg Ser Val Arg Arg Leu 
    370                 375                 380                 


Ser Arg Thr Ile Lys Gly Val Glu Tyr Phe Glu Val Ile Thr Phe Glu 
385                 390                 395                 400 


Met Gly Gln Lys Lys Ala Pro Asp Gly Arg Ile Val Glu Leu Val Lys 
                405                 410                 415     


Glu Val Ser Lys Ser Tyr Pro Ile Ser Glu Gly Pro Glu Arg Ala Asn 
            420                 425                 430         


Glu Leu Val Glu Ser Tyr Arg Lys Ala Ser Asn Lys Ala Tyr Phe Glu 
        435                 440                 445             


Trp Thr Ile Glu Ala Arg Asp Leu Ser Leu Leu Gly Ser His Val Arg 
    450                 455                 460                 


Lys Ala Thr Tyr Gln Thr Tyr Ala Pro Gln Thr Ser Ile Thr Leu Thr 
465                 470                 475                 480 


Ser Asn Ala Ser Gly Thr Phe Asp Gly Tyr Tyr Tyr Glu Leu Trp Lys 
                485                 490                 495     


Asp Thr Gly Asn Thr Thr Met Thr Val Tyr Thr Gln Gly Arg Phe Ser 
            500                 505                 510         


Cys Gln Trp Ser Asn Ile Asn Asn Ala Leu Phe Arg Thr Gly Lys Lys 
        515                 520                 525             


Tyr Asn Gln Asn Trp Gln Ser Leu Gly Thr Ile Arg Ile Thr Tyr Ser 
    530                 535                 540                 


Ala Thr Tyr Asn Pro Asn Gly Asn Ser Tyr Leu Cys Ile Tyr Gly Trp 
545                 550                 555                 560 


Ser Thr Asn Pro Leu Val Glu Phe Tyr Ile Val Glu Ser Trp Gly Asn 
                565                 570                 575     


Trp Arg Pro Pro Gly Ala Thr Ser Leu Gly Gln Val Thr Ile Asp Gly 
            580                 585                 590         


Gly Thr Tyr Asp Ile Tyr Arg Thr Thr Arg Val Asn Gln Pro Ser Ile 
        595                 600                 605             


Val Gly Thr Ala Thr Phe Asp Gln Tyr Trp Ser Val Arg Thr Ser Lys 
    610                 615                 620                 


Arg Thr Ser Gly Thr Val Thr Val Thr Asp His Phe Arg Ala Trp Ala 
625                 630                 635                 640 


Asn Arg Gly Leu Asn Leu Gly Thr Ile Asp Gln Ile Thr Leu Cys Val 
                645                 650                 655     


Glu Gly Tyr Gln Ser Ser Gly Ser Ala Asn Ile Thr Gln Asn Thr Phe 
            660                 665                 670         


Ser Arg Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys Glu Asp Asp Tyr 
        675                 680                 685             


Tyr Gly Ile Thr Leu Ser Asp Asp Ser Asp His Gln Phe Leu Leu Ala 
    690                 695                 700                 


Asn Gln Val Val Val His Asn Ser Phe Ser Gln Tyr Gly Ala Gly Leu 
705                 710                 715                 720 


Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser 
                725                 730                 735     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            740                 745                 750         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        755                 760                 765             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    770                 775                 780                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795                 


<210>  690
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS312:mVMA:P77Cd protein

<400>  690

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            260                 265                 270         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        275                 280                 285             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    290                 295                 300                 


Ala Pro Gly Val Asn Val Gln Cys Phe Ala Lys Gly Thr Asn Val Leu 
305                 310                 315                 320 


Met Ala Asp Gly Ser Ile Glu Cys Ile Glu Asn Ile Glu Val Gly Asn 
                325                 330                 335     


Lys Val Met Gly Lys Asp Gly Arg Pro Arg Glu Val Ile Lys Leu Pro 
            340                 345                 350         


Arg Gly Arg Glu Thr Met Tyr Ser Val Val Gln Lys Ser Gln His Arg 
        355                 360                 365             


Ala His Lys Ser Asp Ser Ser Arg Glu Val Pro Glu Leu Leu Lys Phe 
    370                 375                 380                 


Thr Cys Asn Ala Thr His Glu Leu Val Val Arg Thr Pro Arg Ser Val 
385                 390                 395                 400 


Arg Arg Leu Ser Arg Thr Ile Lys Gly Val Glu Tyr Phe Glu Val Ile 
                405                 410                 415     


Thr Phe Glu Met Gly Gln Lys Lys Ala Pro Asp Gly Arg Ile Val Glu 
            420                 425                 430         


Leu Val Lys Glu Val Ser Lys Ser Tyr Pro Ile Ser Glu Gly Pro Glu 
        435                 440                 445             


Arg Ala Asn Glu Leu Val Glu Ser Tyr Arg Lys Ala Ser Asn Lys Ala 
    450                 455                 460                 


Tyr Phe Glu Trp Thr Ile Glu Ala Arg Asp Leu Ser Leu Leu Gly Ser 
465                 470                 475                 480 


His Val Arg Lys Ala Thr Tyr Gln Thr Tyr Ala Pro Gln Thr Ser Ile 
                485                 490                 495     


Thr Leu Thr Ser Asn Ala Ser Gly Thr Phe Asp Gly Tyr Tyr Tyr Glu 
            500                 505                 510         


Leu Trp Lys Asp Thr Gly Asn Thr Thr Met Thr Val Tyr Thr Gln Gly 
        515                 520                 525             


Arg Phe Ser Cys Gln Trp Ser Asn Ile Asn Asn Ala Leu Phe Arg Thr 
    530                 535                 540                 


Gly Lys Lys Tyr Asn Gln Asn Trp Gln Ser Leu Gly Thr Ile Arg Ile 
545                 550                 555                 560 


Thr Tyr Ser Ala Thr Tyr Asn Pro Asn Gly Asn Ser Tyr Leu Cys Ile 
                565                 570                 575     


Tyr Gly Trp Ser Thr Asn Pro Leu Val Glu Phe Tyr Ile Val Glu Ser 
            580                 585                 590         


Trp Gly Asn Trp Arg Pro Pro Gly Ala Thr Ser Leu Gly Gln Val Thr 
        595                 600                 605             


Ile Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Thr Thr Arg Val Asn Gln 
    610                 615                 620                 


Pro Ser Ile Val Gly Thr Ala Thr Phe Asp Gln Tyr Trp Ser Val Arg 
625                 630                 635                 640 


Thr Ser Lys Arg Thr Ser Gly Thr Val Thr Val Thr Asp His Phe Arg 
                645                 650                 655     


Ala Trp Ala Asn Arg Gly Leu Asn Leu Gly Thr Ile Asp Gln Ile Thr 
            660                 665                 670         


Leu Cys Val Glu Gly Tyr Gln Ser Ser Gly Ser Ala Asn Ile Thr Gln 
        675                 680                 685             


Asn Thr Phe Ser Arg Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys Glu 
    690                 695                 700                 


Asp Asp Tyr Tyr Gly Ile Thr Leu Ser Asp Asp Ser Asp His Gln Phe 
705                 710                 715                 720 


Leu Leu Ala Asn Gln Val Val Val His Asn Ser Thr Tyr Pro Gly Ser 
                725                 730                 735     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            740                 745                 750         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        755                 760                 765             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    770                 775                 780                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795                 


<210>  691
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS317:mVMA:P77Cd protein

<400>  691

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            260                 265                 270         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        275                 280                 285             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    290                 295                 300                 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Cys Phe Ala Lys 
305                 310                 315                 320 


Gly Thr Asn Val Leu Met Ala Asp Gly Ser Ile Glu Cys Ile Glu Asn 
                325                 330                 335     


Ile Glu Val Gly Asn Lys Val Met Gly Lys Asp Gly Arg Pro Arg Glu 
            340                 345                 350         


Val Ile Lys Leu Pro Arg Gly Arg Glu Thr Met Tyr Ser Val Val Gln 
        355                 360                 365             


Lys Ser Gln His Arg Ala His Lys Ser Asp Ser Ser Arg Glu Val Pro 
    370                 375                 380                 


Glu Leu Leu Lys Phe Thr Cys Asn Ala Thr His Glu Leu Val Val Arg 
385                 390                 395                 400 


Thr Pro Arg Ser Val Arg Arg Leu Ser Arg Thr Ile Lys Gly Val Glu 
                405                 410                 415     


Tyr Phe Glu Val Ile Thr Phe Glu Met Gly Gln Lys Lys Ala Pro Asp 
            420                 425                 430         


Gly Arg Ile Val Glu Leu Val Lys Glu Val Ser Lys Ser Tyr Pro Ile 
        435                 440                 445             


Ser Glu Gly Pro Glu Arg Ala Asn Glu Leu Val Glu Ser Tyr Arg Lys 
    450                 455                 460                 


Ala Ser Asn Lys Ala Tyr Phe Glu Trp Thr Ile Glu Ala Arg Asp Leu 
465                 470                 475                 480 


Ser Leu Leu Gly Ser His Val Arg Lys Ala Thr Tyr Gln Thr Tyr Ala 
                485                 490                 495     


Pro Gln Thr Ser Ile Thr Leu Thr Ser Asn Ala Ser Gly Thr Phe Asp 
            500                 505                 510         


Gly Tyr Tyr Tyr Glu Leu Trp Lys Asp Thr Gly Asn Thr Thr Met Thr 
        515                 520                 525             


Val Tyr Thr Gln Gly Arg Phe Ser Cys Gln Trp Ser Asn Ile Asn Asn 
    530                 535                 540                 


Ala Leu Phe Arg Thr Gly Lys Lys Tyr Asn Gln Asn Trp Gln Ser Leu 
545                 550                 555                 560 


Gly Thr Ile Arg Ile Thr Tyr Ser Ala Thr Tyr Asn Pro Asn Gly Asn 
                565                 570                 575     


Ser Tyr Leu Cys Ile Tyr Gly Trp Ser Thr Asn Pro Leu Val Glu Phe 
            580                 585                 590         


Tyr Ile Val Glu Ser Trp Gly Asn Trp Arg Pro Pro Gly Ala Thr Ser 
        595                 600                 605             


Leu Gly Gln Val Thr Ile Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Thr 
    610                 615                 620                 


Thr Arg Val Asn Gln Pro Ser Ile Val Gly Thr Ala Thr Phe Asp Gln 
625                 630                 635                 640 


Tyr Trp Ser Val Arg Thr Ser Lys Arg Thr Ser Gly Thr Val Thr Val 
                645                 650                 655     


Thr Asp His Phe Arg Ala Trp Ala Asn Arg Gly Leu Asn Leu Gly Thr 
            660                 665                 670         


Ile Asp Gln Ile Thr Leu Cys Val Glu Gly Tyr Gln Ser Ser Gly Ser 
        675                 680                 685             


Ala Asn Ile Thr Gln Asn Thr Phe Ser Arg Gly Phe Tyr Phe Glu Leu 
    690                 695                 700                 


Gln Glu Leu Lys Glu Asp Asp Tyr Tyr Gly Ile Thr Leu Ser Asp Asp 
705                 710                 715                 720 


Ser Asp His Gln Phe Leu Leu Ala Asn Gln Val Val Val His Asn Ser 
                725                 730                 735     


Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala 
            740                 745                 750         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        755                 760                 765             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    770                 775                 780                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795                 


<210>  692
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS326:mVMA:P77Cd protein

<400>  692

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Glu Glu Ala Lys 
            20                  25                  30          


Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln Glu Ala Val Ser Glu Phe 
        35                  40                  45              


Val Glu Gln Val Glu Ala Asn Asp Glu Val Ala Ile Leu Ser Glu Glu 
    50                  55                  60                  


Glu Glu Val Glu Ile Glu Leu Leu His Glu Phe Glu Thr Ile Pro Val 
65                  70                  75                  80  


Leu Ser Val Glu Leu Ser Pro Glu Asp Val Asp Ala Leu Glu Leu Asp 
                85                  90                  95      


Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala Glu Val Thr Thr Met Ala 
            100                 105                 110         


Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala His 
        115                 120                 125             


Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp Thr 
    130                 135                 140                 


Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser Phe 
145                 150                 155                 160 


Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr His 
                165                 170                 175     


Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu Gly 
            180                 185                 190         


Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala Ser 
        195                 200                 205             


Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala Gly 
    210                 215                 220                 


Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser Pro 
225                 230                 235                 240 


Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly Val 
                245                 250                 255     


Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser Tyr 
            260                 265                 270         


Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln Asn 
        275                 280                 285             


Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile Val 
    290                 295                 300                 


Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
305                 310                 315                 320 


Ser Leu Asn Gly Thr Cys Phe Ala Lys Gly Thr Asn Val Leu Met Ala 
                325                 330                 335     


Asp Gly Ser Ile Glu Cys Ile Glu Asn Ile Glu Val Gly Asn Lys Val 
            340                 345                 350         


Met Gly Lys Asp Gly Arg Pro Arg Glu Val Ile Lys Leu Pro Arg Gly 
        355                 360                 365             


Arg Glu Thr Met Tyr Ser Val Val Gln Lys Ser Gln His Arg Ala His 
    370                 375                 380                 


Lys Ser Asp Ser Ser Arg Glu Val Pro Glu Leu Leu Lys Phe Thr Cys 
385                 390                 395                 400 


Asn Ala Thr His Glu Leu Val Val Arg Thr Pro Arg Ser Val Arg Arg 
                405                 410                 415     


Leu Ser Arg Thr Ile Lys Gly Val Glu Tyr Phe Glu Val Ile Thr Phe 
            420                 425                 430         


Glu Met Gly Gln Lys Lys Ala Pro Asp Gly Arg Ile Val Glu Leu Val 
        435                 440                 445             


Lys Glu Val Ser Lys Ser Tyr Pro Ile Ser Glu Gly Pro Glu Arg Ala 
    450                 455                 460                 


Asn Glu Leu Val Glu Ser Tyr Arg Lys Ala Ser Asn Lys Ala Tyr Phe 
465                 470                 475                 480 


Glu Trp Thr Ile Glu Ala Arg Asp Leu Ser Leu Leu Gly Ser His Val 
                485                 490                 495     


Arg Lys Ala Thr Tyr Gln Thr Tyr Ala Pro Gln Thr Ser Ile Thr Leu 
            500                 505                 510         


Thr Ser Asn Ala Ser Gly Thr Phe Asp Gly Tyr Tyr Tyr Glu Leu Trp 
        515                 520                 525             


Lys Asp Thr Gly Asn Thr Thr Met Thr Val Tyr Thr Gln Gly Arg Phe 
    530                 535                 540                 


Ser Cys Gln Trp Ser Asn Ile Asn Asn Ala Leu Phe Arg Thr Gly Lys 
545                 550                 555                 560 


Lys Tyr Asn Gln Asn Trp Gln Ser Leu Gly Thr Ile Arg Ile Thr Tyr 
                565                 570                 575     


Ser Ala Thr Tyr Asn Pro Asn Gly Asn Ser Tyr Leu Cys Ile Tyr Gly 
            580                 585                 590         


Trp Ser Thr Asn Pro Leu Val Glu Phe Tyr Ile Val Glu Ser Trp Gly 
        595                 600                 605             


Asn Trp Arg Pro Pro Gly Ala Thr Ser Leu Gly Gln Val Thr Ile Asp 
    610                 615                 620                 


Gly Gly Thr Tyr Asp Ile Tyr Arg Thr Thr Arg Val Asn Gln Pro Ser 
625                 630                 635                 640 


Ile Val Gly Thr Ala Thr Phe Asp Gln Tyr Trp Ser Val Arg Thr Ser 
                645                 650                 655     


Lys Arg Thr Ser Gly Thr Val Thr Val Thr Asp His Phe Arg Ala Trp 
            660                 665                 670         


Ala Asn Arg Gly Leu Asn Leu Gly Thr Ile Asp Gln Ile Thr Leu Cys 
        675                 680                 685             


Val Glu Gly Tyr Gln Ser Ser Gly Ser Ala Asn Ile Thr Gln Asn Thr 
    690                 695                 700                 


Phe Ser Arg Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys Glu Asp Asp 
705                 710                 715                 720 


Tyr Tyr Gly Ile Thr Leu Ser Asp Asp Ser Asp His Gln Phe Leu Leu 
                725                 730                 735     


Ala Asn Gln Val Val Val His Asn Ser Met Ala Thr Pro His Val Ala 
            740                 745                 750         


Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val 
        755                 760                 765             


Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr 
    770                 775                 780                 


Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795                 


<210>  693
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS135:mTth:P77Cd

<400>  693

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Cys Leu Ala Glu 
            100                 105                 110         


Gly Ser Leu Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu 
        115                 120                 125             


Lys Val Arg Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg 
    130                 135                 140                 


Leu Tyr Arg Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu 
145                 150                 155                 160 


Val Val Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro 
                165                 170                 175     


Asp His Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu 
            180                 185                 190         


Pro Leu Gly Thr Pro Ile Ala Val Gln Thr Ser Ile Thr Leu Thr Ser 
        195                 200                 205             


Asn Ala Ser Gly Thr Phe Asp Gly Tyr Tyr Tyr Glu Leu Trp Lys Asp 
    210                 215                 220                 


Thr Gly Asn Thr Thr Met Thr Val Tyr Thr Gln Gly Arg Phe Ser Cys 
225                 230                 235                 240 


Gln Trp Ser Asn Ile Asn Asn Ala Leu Phe Arg Thr Gly Lys Lys Tyr 
                245                 250                 255     


Asn Gln Asn Trp Gln Ser Leu Gly Thr Ile Arg Ile Thr Tyr Ser Ala 
            260                 265                 270         


Thr Tyr Asn Pro Asn Gly Asn Ser Tyr Leu Cys Ile Tyr Gly Trp Ser 
        275                 280                 285             


Thr Asn Pro Leu Val Glu Phe Tyr Ile Val Glu Ser Trp Gly Asn Trp 
    290                 295                 300                 


Arg Pro Pro Gly Ala Thr Ser Leu Gly Gln Val Thr Ile Asp Gly Gly 
305                 310                 315                 320 


Thr Tyr Asp Ile Tyr Arg Thr Thr Arg Val Asn Gln Pro Ser Ile Val 
                325                 330                 335     


Gly Thr Ala Thr Phe Asp Gln Tyr Trp Ser Val Arg Thr Ser Lys Arg 
            340                 345                 350         


Thr Ser Gly Thr Val Thr Val Thr Asp His Phe Arg Ala Trp Ala Asn 
        355                 360                 365             


Arg Gly Leu Asn Leu Gly Thr Ile Asp Gln Ile Thr Leu Cys Val Glu 
    370                 375                 380                 


Gly Tyr Gln Ser Ser Gly Ser Ala Asn Ile Thr Gln Asn Thr Phe Ser 
385                 390                 395                 400 


Arg Asp Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val 
                405                 410                 415     


Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe 
            420                 425                 430         


Ala Asn Phe Val Ser Glu Asp Leu Val Val His Asn Ser Gly Val Lys 
        435                 440                 445             


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
    450                 455                 460                 


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
465                 470                 475                 480 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
                485                 490                 495     


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
            500                 505                 510         


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
        515                 520                 525             


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
    530                 535                 540                 


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
545                 550                 555                 560 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
                565                 570                 575     


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
            580                 585                 590         


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
        595                 600                 605             


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
    610                 615                 620                 


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
625                 630                 635                 640 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
                645                 650                 655     


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
            660                 665                 670         


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
        675                 680                 685             


Thr Arg 
    690 


<210>  694
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS269:mTth:P77Cd

<400>  694

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly 
                245                 250                 255     


Gln Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser 
            260                 265                 270         


Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu 
        275                 280                 285             


Glu Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg 
    290                 295                 300                 


Thr Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp 
305                 310                 315                 320 


Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Gln Thr 
                325                 330                 335     


Ser Ile Thr Leu Thr Ser Asn Ala Ser Gly Thr Phe Asp Gly Tyr Tyr 
            340                 345                 350         


Tyr Glu Leu Trp Lys Asp Thr Gly Asn Thr Thr Met Thr Val Tyr Thr 
        355                 360                 365             


Gln Gly Arg Phe Ser Cys Gln Trp Ser Asn Ile Asn Asn Ala Leu Phe 
    370                 375                 380                 


Arg Thr Gly Lys Lys Tyr Asn Gln Asn Trp Gln Ser Leu Gly Thr Ile 
385                 390                 395                 400 


Arg Ile Thr Tyr Ser Ala Thr Tyr Asn Pro Asn Gly Asn Ser Tyr Leu 
                405                 410                 415     


Cys Ile Tyr Gly Trp Ser Thr Asn Pro Leu Val Glu Phe Tyr Ile Val 
            420                 425                 430         


Glu Ser Trp Gly Asn Trp Arg Pro Pro Gly Ala Thr Ser Leu Gly Gln 
        435                 440                 445             


Val Thr Ile Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Thr Thr Arg Val 
    450                 455                 460                 


Asn Gln Pro Ser Ile Val Gly Thr Ala Thr Phe Asp Gln Tyr Trp Ser 
465                 470                 475                 480 


Val Arg Thr Ser Lys Arg Thr Ser Gly Thr Val Thr Val Thr Asp His 
                485                 490                 495     


Phe Arg Ala Trp Ala Asn Arg Gly Leu Asn Leu Gly Thr Ile Asp Gln 
            500                 505                 510         


Ile Thr Leu Cys Val Glu Gly Tyr Gln Ser Ser Gly Ser Ala Asn Ile 
        515                 520                 525             


Thr Gln Asn Thr Phe Ser Arg Asp Val Glu Thr Gly Glu Val Leu Trp 
    530                 535                 540                 


Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp 
545                 550                 555                 560 


Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val Val 
                565                 570                 575     


His Asn Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
            580                 585                 590         


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
        595                 600                 605             


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
    610                 615                 620                 


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
625                 630                 635                 640 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
                645                 650                 655     


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
            660                 665                 670         


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
        675                 680                 685             


Thr Arg 
    690 


<210>  695
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS293:mTth:P77Cd

<400>  695

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Cys Leu Ala Glu Gly Ser 
            260                 265                 270         


Leu Val Leu Asp Ala Ala Thr Gly Gln Arg Val Pro Ile Glu Lys Val 
        275                 280                 285             


Arg Pro Gly Met Glu Val Phe Ser Leu Gly Pro Asp Tyr Arg Leu Tyr 
    290                 295                 300                 


Arg Val Pro Val Leu Glu Val Leu Glu Ser Gly Val Arg Glu Val Val 
305                 310                 315                 320 


Arg Leu Arg Thr Arg Ser Gly Arg Thr Leu Val Leu Thr Pro Asp His 
                325                 330                 335     


Pro Leu Leu Thr Pro Glu Gly Trp Lys Pro Leu Cys Asp Leu Pro Leu 
            340                 345                 350         


Gly Thr Pro Ile Ala Val Gln Thr Ser Ile Thr Leu Thr Ser Asn Ala 
        355                 360                 365             


Ser Gly Thr Phe Asp Gly Tyr Tyr Tyr Glu Leu Trp Lys Asp Thr Gly 
    370                 375                 380                 


Asn Thr Thr Met Thr Val Tyr Thr Gln Gly Arg Phe Ser Cys Gln Trp 
385                 390                 395                 400 


Ser Asn Ile Asn Asn Ala Leu Phe Arg Thr Gly Lys Lys Tyr Asn Gln 
                405                 410                 415     


Asn Trp Gln Ser Leu Gly Thr Ile Arg Ile Thr Tyr Ser Ala Thr Tyr 
            420                 425                 430         


Asn Pro Asn Gly Asn Ser Tyr Leu Cys Ile Tyr Gly Trp Ser Thr Asn 
        435                 440                 445             


Pro Leu Val Glu Phe Tyr Ile Val Glu Ser Trp Gly Asn Trp Arg Pro 
    450                 455                 460                 


Pro Gly Ala Thr Ser Leu Gly Gln Val Thr Ile Asp Gly Gly Thr Tyr 
465                 470                 475                 480 


Asp Ile Tyr Arg Thr Thr Arg Val Asn Gln Pro Ser Ile Val Gly Thr 
                485                 490                 495     


Ala Thr Phe Asp Gln Tyr Trp Ser Val Arg Thr Ser Lys Arg Thr Ser 
            500                 505                 510         


Gly Thr Val Thr Val Thr Asp His Phe Arg Ala Trp Ala Asn Arg Gly 
        515                 520                 525             


Leu Asn Leu Gly Thr Ile Asp Gln Ile Thr Leu Cys Val Glu Gly Tyr 
    530                 535                 540                 


Gln Ser Ser Gly Ser Ala Asn Ile Thr Gln Asn Thr Phe Ser Arg Asp 
545                 550                 555                 560 


Val Glu Thr Gly Glu Val Leu Trp Asp Pro Ile Val Ala Val Glu Pro 
                565                 570                 575     


Ala Gly Lys Ala Arg Thr Phe Asp Leu Arg Val Pro Pro Phe Ala Asn 
            580                 585                 590         


Phe Val Ser Glu Asp Leu Val Val His Asn Ser Phe Ser Gln Tyr Gly 
        595                 600                 605             


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
    610                 615                 620                 


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
625                 630                 635                 640 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
                645                 650                 655     


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
            660                 665                 670         


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
        675                 680                 685             


Thr Arg 
    690 


<210>  696
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS317:mTth:P77Cd

<400>  696

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Cys Leu Ala Glu Gly Ser Leu Val Leu Asp Ala Ala Thr Gly 
    290                 295                 300                 


Gln Arg Val Pro Ile Glu Lys Val Arg Pro Gly Met Glu Val Phe Ser 
305                 310                 315                 320 


Leu Gly Pro Asp Tyr Arg Leu Tyr Arg Val Pro Val Leu Glu Val Leu 
                325                 330                 335     


Glu Ser Gly Val Arg Glu Val Val Arg Leu Arg Thr Arg Ser Gly Arg 
            340                 345                 350         


Thr Leu Val Leu Thr Pro Asp His Pro Leu Leu Thr Pro Glu Gly Trp 
        355                 360                 365             


Lys Pro Leu Cys Asp Leu Pro Leu Gly Thr Pro Ile Ala Val Gln Thr 
    370                 375                 380                 


Ser Ile Thr Leu Thr Ser Asn Ala Ser Gly Thr Phe Asp Gly Tyr Tyr 
385                 390                 395                 400 


Tyr Glu Leu Trp Lys Asp Thr Gly Asn Thr Thr Met Thr Val Tyr Thr 
                405                 410                 415     


Gln Gly Arg Phe Ser Cys Gln Trp Ser Asn Ile Asn Asn Ala Leu Phe 
            420                 425                 430         


Arg Thr Gly Lys Lys Tyr Asn Gln Asn Trp Gln Ser Leu Gly Thr Ile 
        435                 440                 445             


Arg Ile Thr Tyr Ser Ala Thr Tyr Asn Pro Asn Gly Asn Ser Tyr Leu 
    450                 455                 460                 


Cys Ile Tyr Gly Trp Ser Thr Asn Pro Leu Val Glu Phe Tyr Ile Val 
465                 470                 475                 480 


Glu Ser Trp Gly Asn Trp Arg Pro Pro Gly Ala Thr Ser Leu Gly Gln 
                485                 490                 495     


Val Thr Ile Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Thr Thr Arg Val 
            500                 505                 510         


Asn Gln Pro Ser Ile Val Gly Thr Ala Thr Phe Asp Gln Tyr Trp Ser 
        515                 520                 525             


Val Arg Thr Ser Lys Arg Thr Ser Gly Thr Val Thr Val Thr Asp His 
    530                 535                 540                 


Phe Arg Ala Trp Ala Asn Arg Gly Leu Asn Leu Gly Thr Ile Asp Gln 
545                 550                 555                 560 


Ile Thr Leu Cys Val Glu Gly Tyr Gln Ser Ser Gly Ser Ala Asn Ile 
                565                 570                 575     


Thr Gln Asn Thr Phe Ser Arg Asp Val Glu Thr Gly Glu Val Leu Trp 
            580                 585                 590         


Asp Pro Ile Val Ala Val Glu Pro Ala Gly Lys Ala Arg Thr Phe Asp 
        595                 600                 605             


Leu Arg Val Pro Pro Phe Ala Asn Phe Val Ser Glu Asp Leu Val Val 
    610                 615                 620                 


His Asn Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro 
625                 630                 635                 640 


His Val Ala Gly Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp 
                645                 650                 655     


Ser Asn Val Gln Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu 
            660                 665                 670         


Gly Ser Thr Asn Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala 
        675                 680                 685             


Thr Arg 
    690 


<210>  697
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS312:mVMA-c:P77Cd

<400>  697

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ala Phe Ala 
        275                 280                 285             


Lys Gly Thr Asn Val Leu Met Ala Asp Gly Ser Ile Glu Cys Ile Glu 
    290                 295                 300                 


Asn Ile Glu Val Gly Asn Lys Val Met Gly Lys Asp Gly Arg Pro Arg 
305                 310                 315                 320 


Glu Val Ile Lys Leu Pro Arg Gly Arg Glu Thr Met Tyr Ser Val Val 
                325                 330                 335     


Gln Lys Ser Gln His Arg Ala His Lys Ser Asp Ser Ser Arg Glu Val 
            340                 345                 350         


Pro Glu Leu Leu Lys Phe Thr Cys Asn Ala Thr His Glu Leu Val Val 
        355                 360                 365             


Arg Thr Pro Arg Ser Val Arg Arg Leu Ser Arg Thr Ile Lys Gly Val 
    370                 375                 380                 


Glu Tyr Phe Glu Val Ile Thr Phe Glu Met Gly Gln Lys Lys Ala Pro 
385                 390                 395                 400 


Asp Gly Arg Ile Val Glu Leu Val Lys Glu Val Ser Lys Ser Tyr Pro 
                405                 410                 415     


Ile Ser Glu Gly Pro Glu Arg Ala Asn Glu Leu Val Glu Ser Tyr Arg 
            420                 425                 430         


Lys Ala Ser Asn Lys Ala Tyr Phe Glu Trp Thr Ile Glu Ala Arg Asp 
        435                 440                 445             


Leu Ser Leu Leu Gly Ser His Val Arg Lys Ala Thr Tyr Gln Thr Tyr 
    450                 455                 460                 


Ala Pro Phe Leu Lys Lys Leu Ser Lys Leu Leu Leu Val Val Leu Leu 
465                 470                 475                 480 


Val Ala Val Tyr Thr Gln Val Asn Ala Gln Thr Ser Ile Thr Leu Thr 
                485                 490                 495     


Ser Asn Ala Ser Gly Thr Phe Asp Gly Tyr Tyr Tyr Glu Leu Trp Lys 
            500                 505                 510         


Asp Thr Gly Asn Thr Thr Met Thr Val Tyr Thr Gln Gly Arg Phe Ser 
        515                 520                 525             


Cys Gln Trp Ser Asn Ile Asn Asn Ala Leu Phe Arg Thr Gly Lys Lys 
    530                 535                 540                 


Tyr Asn Gln Asn Trp Gln Ser Leu Gly Thr Ile Arg Ile Thr Tyr Ser 
545                 550                 555                 560 


Ala Thr Tyr Asn Pro Asn Gly Asn Ser Tyr Leu Cys Ile Tyr Gly Trp 
                565                 570                 575     


Ser Thr Asn Pro Leu Val Glu Phe Tyr Ile Val Glu Ser Trp Gly Asn 
            580                 585                 590         


Trp Arg Pro Pro Gly Ala Thr Ser Leu Gly Gln Val Thr Ile Asp Gly 
        595                 600                 605             


Gly Thr Tyr Asp Ile Tyr Arg Thr Thr Arg Val Asn Gln Pro Ser Ile 
    610                 615                 620                 


Val Gly Thr Ala Thr Phe Asp Gln Tyr Trp Ser Val Arg Thr Ser Lys 
625                 630                 635                 640 


Arg Thr Ser Gly Thr Val Thr Val Thr Asp His Phe Arg Ala Trp Ala 
                645                 650                 655     


Asn Arg Gly Leu Asn Leu Gly Thr Ile Asp Gln Ile Thr Leu Cys Val 
            660                 665                 670         


Glu Gly Tyr Gln Ser Ser Gly Ser Ala Asn Ile Thr Gln Asn Thr Phe 
        675                 680                 685             


Ser Arg Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys Glu Asp Asp Tyr 
    690                 695                 700                 


Tyr Gly Ile Thr Leu Ser Asp Asp Ser Asp His Gln Phe Leu Leu Ala 
705                 710                 715                 720 


Asn Gln Val Val Val His Ala Ser Thr Tyr Pro Gly Ser Thr Tyr Ala 
                725                 730                 735     


Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
            740                 745                 750         


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
        755                 760                 765             


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
    770                 775                 780                 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795     


<210>  698
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS326:mVMA-c:P77Cd

<400>  698

Met Ala Glu Glu Ala Lys Glu Lys Tyr Leu Ile Gly Phe Asn Glu Gln 
1               5                   10                  15      


Glu Ala Val Ser Glu Phe Val Glu Gln Val Glu Ala Asn Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Ser Glu Glu Glu Glu Val Glu Ile Glu Leu Leu His Glu 
        35                  40                  45              


Phe Glu Thr Ile Pro Val Leu Ser Val Glu Leu Ser Pro Glu Asp Val 
    50                  55                  60                  


Asp Ala Leu Glu Leu Asp Pro Ala Ile Ser Tyr Ile Glu Glu Asp Ala 
65                  70                  75                  80  


Glu Val Thr Thr Met Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val 
                85                  90                  95      


Gln Ala Pro Ala Ala His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys 
            100                 105                 110         


Val Ala Val Leu Asp Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile 
        115                 120                 125             


Arg Gly Gly Ala Ser Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly 
    130                 135                 140                 


Asn Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn 
145                 150                 155                 160 


Ser Ile Gly Val Leu Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val 
                165                 170                 175     


Lys Val Leu Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln 
            180                 185                 190         


Gly Leu Glu Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser 
        195                 200                 205             


Leu Gly Ser Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser 
    210                 215                 220                 


Ala Thr Ser Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Ile Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val 
                245                 250                 255     


Gly Ala Thr Asp Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly 
            260                 265                 270         


Ala Gly Leu Asp Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr 
        275                 280                 285             


Pro Gly Ser Thr Tyr Ala Ser Leu Asn Gly Thr Ala Phe Ala Lys Gly 
    290                 295                 300                 


Thr Asn Val Leu Met Ala Asp Gly Ser Ile Glu Cys Ile Glu Asn Ile 
305                 310                 315                 320 


Glu Val Gly Asn Lys Val Met Gly Lys Asp Gly Arg Pro Arg Glu Val 
                325                 330                 335     


Ile Lys Leu Pro Arg Gly Arg Glu Thr Met Tyr Ser Val Val Gln Lys 
            340                 345                 350         


Ser Gln His Arg Ala His Lys Ser Asp Ser Ser Arg Glu Val Pro Glu 
        355                 360                 365             


Leu Leu Lys Phe Thr Cys Asn Ala Thr His Glu Leu Val Val Arg Thr 
    370                 375                 380                 


Pro Arg Ser Val Arg Arg Leu Ser Arg Thr Ile Lys Gly Val Glu Tyr 
385                 390                 395                 400 


Phe Glu Val Ile Thr Phe Glu Met Gly Gln Lys Lys Ala Pro Asp Gly 
                405                 410                 415     


Arg Ile Val Glu Leu Val Lys Glu Val Ser Lys Ser Tyr Pro Ile Ser 
            420                 425                 430         


Glu Gly Pro Glu Arg Ala Asn Glu Leu Val Glu Ser Tyr Arg Lys Ala 
        435                 440                 445             


Ser Asn Lys Ala Tyr Phe Glu Trp Thr Ile Glu Ala Arg Asp Leu Ser 
    450                 455                 460                 


Leu Leu Gly Ser His Val Arg Lys Ala Thr Tyr Gln Thr Tyr Ala Pro 
465                 470                 475                 480 


Phe Leu Lys Lys Leu Ser Lys Leu Leu Leu Val Val Leu Leu Val Ala 
                485                 490                 495     


Val Tyr Thr Gln Val Asn Ala Gln Thr Ser Ile Thr Leu Thr Ser Asn 
            500                 505                 510         


Ala Ser Gly Thr Phe Asp Gly Tyr Tyr Tyr Glu Leu Trp Lys Asp Thr 
        515                 520                 525             


Gly Asn Thr Thr Met Thr Val Tyr Thr Gln Gly Arg Phe Ser Cys Gln 
    530                 535                 540                 


Trp Ser Asn Ile Asn Asn Ala Leu Phe Arg Thr Gly Lys Lys Tyr Asn 
545                 550                 555                 560 


Gln Asn Trp Gln Ser Leu Gly Thr Ile Arg Ile Thr Tyr Ser Ala Thr 
                565                 570                 575     


Tyr Asn Pro Asn Gly Asn Ser Tyr Leu Cys Ile Tyr Gly Trp Ser Thr 
            580                 585                 590         


Asn Pro Leu Val Glu Phe Tyr Ile Val Glu Ser Trp Gly Asn Trp Arg 
        595                 600                 605             


Pro Pro Gly Ala Thr Ser Leu Gly Gln Val Thr Ile Asp Gly Gly Thr 
    610                 615                 620                 


Tyr Asp Ile Tyr Arg Thr Thr Arg Val Asn Gln Pro Ser Ile Val Gly 
625                 630                 635                 640 


Thr Ala Thr Phe Asp Gln Tyr Trp Ser Val Arg Thr Ser Lys Arg Thr 
                645                 650                 655     


Ser Gly Thr Val Thr Val Thr Asp His Phe Arg Ala Trp Ala Asn Arg 
            660                 665                 670         


Gly Leu Asn Leu Gly Thr Ile Asp Gln Ile Thr Leu Cys Val Glu Gly 
        675                 680                 685             


Tyr Gln Ser Ser Gly Ser Ala Asn Ile Thr Gln Asn Thr Phe Ser Arg 
    690                 695                 700                 


Gly Phe Tyr Phe Glu Leu Gln Glu Leu Lys Glu Asp Asp Tyr Tyr Gly 
705                 710                 715                 720 


Ile Thr Leu Ser Asp Asp Ser Asp His Gln Phe Leu Leu Ala Asn Gln 
                725                 730                 735     


Val Val Val His Ala Ser Met Ala Thr Pro His Val Ala Gly Ala Ala 
            740                 745                 750         


Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile Arg 
        755                 760                 765             


Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu Tyr 
    770                 775                 780                 


Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
785                 790                 795     


<210>  699
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, mVMA:P77cd DNA

<400>  699
tgctttgcca agggtaccaa tgttttaatg gcggatgggt ctattgaatg tattgaaaac       60

attgaggttg gtaataaggt catgggtaaa gatggcagac ctcgtgaggt aattaaattg      120

cccagaggaa gagaaactat gtacagcgtc gtgcagaaaa gtcagcacag agcccacaaa      180

agtgactcaa gtcgtgaagt gccagaatta ctcaagttta cgtgtaatgc gacccatgag      240

ttggttgtta gaacacctcg tagtgtccgc cgtttgtctc gtaccattaa gggtgtcgaa      300

tattttgaag ttattacttt tgagatgggc caaaagaaag cccccgacgg tagaattgtt      360

gagcttgtca aggaagtttc aaagagctac ccaatatctg aggggcctga gagagccaac      420

gaattagtag aatcctatag aaaggcttca aataaagctt attttgagtg gactattgag      480

gccagagatc tttctctgtt gggttcccat gttcgtaaag ctacctacca gacttacgct      540

ccacaaacaa gcattactct gacatccaac gcatccggta cgtttgacgg ttactattac      600

gaactctgga aggatactgg caatacaaca atgacggtct acactcaagg tcgcttttcc      660

tgccagtggt cgaacatcaa taacgcgttg tttaggaccg ggaagaaata caaccagaat      720

tggcagtctc ttggcacaat ccggatcacg tactctgcga cttacaaccc aaacgggaac      780

tcctacttgt gtatctatgg ctggtctacc aacccattgg tcgagttcta catcgttgag      840

tcctggggga actggagacc gcctggtgcc acgtccctgg gccaagtgac aatcgatggc      900

gggacctacg acatctatag gacgacacgc gtcaaccagc cttccattgt ggggacagcc      960

acgttcgatc agtactggag cgtgcgcacc tctaagcgga cttcaggaac agtgaccgtg     1020

accgatcact tccgcgcctg ggcgaaccgg ggcctgaacc tcggcacaat agaccaaatt     1080

acattgtgcg tggagggtta ccaaagctct ggatcagcca acatcaccca gaacaccttc     1140

tctcgcggat tttatttcga gttacaagaa ttgaaggaag acgattatta tgggattact     1200

ttatctgatg attctgatca tcagtttttg cttgccaacc aggttgtcgt ccataat        1257


<210>  700
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct mTth:P77Cd

<400>  700
tgcctggccg agggctcgct cgtcttggac gcggctaccg ggcagagggt ccctatcgaa       60

aaggtgcgtc cggggatgga agttttctcc ttgggacctg attacagact gtatcgggtg      120

cccgttttgg aggtccttga gagcggggtt agggaagttg tgcgcctcag aactcggtca      180

gggagaacgc tggtgttgac accagatcac ccgcttttga cccccgaagg ttggaaacct      240

ctttgtgacc tcccgcttgg aactccaatt gcagtccaaa caagcattac tctgacatcc      300

aacgcatccg gtacgtttga cggttactat tacgaactct ggaaggatac tggcaataca      360

acaatgacgg tctacactca aggtcgcttt tcctgccagt ggtcgaacat caataacgcg      420

ttgtttagga ccgggaagaa atacaaccag aattggcagt ctcttggcac aatccggatc      480

acgtactctg cgacttacaa cccaaacggg aactcctact tgtgtatcta tggctggtct      540

accaacccat tggtcgagtt ctacatcgtt gagtcctggg ggaactggag accgcctggt      600

gccacgtccc tgggccaagt gacaatcgat ggcgggacct acgacatcta taggacgaca      660

cgcgtcaacc agccttccat tgtggggaca gccacgttcg atcagtactg gagcgtgcgc      720

acctctaagc ggacttcagg aacagtgacc gtgaccgatc acttccgcgc ctgggcgaac      780

cggggcctga acctcggcac aatagaccaa attacattgt gcgtggaggg ttaccaaagc      840

tctggatcag ccaacatcac ccagaacacc ttctctagag atgttgagac tggagaggtt      900

ctctgggacc ctattgttgc tgtcgaaccg gccggtaagg cgagaacatt cgacttgcgc      960

gttccaccct ttgcaaactt cgtgagcgag gacctggtgg tgcataac                  1008


<210>  701
<211>  2400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS135:mVMA:P77Cd DNA

<400>  701
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttgctttgc caagggtacc      420

aatgttttaa tggcggatgg gtctattgaa tgtattgaaa acattgaggt tggtaataag      480

gtcatgggta aagatggcag acctcgtgag gtaattaaat tgcccagagg aagagaaact      540

atgtacagcg tcgtgcagaa aagtcagcac agagcccaca aaagtgactc aagtcgtgaa      600

gtgccagaat tactcaagtt tacgtgtaat gcgacccatg agttggttgt tagaacacct      660

cgtagtgtcc gccgtttgtc tcgtaccatt aagggtgtcg aatattttga agttattact      720

tttgagatgg gccaaaagaa agcccccgac ggtagaattg ttgagcttgt caaggaagtt      780

tcaaagagct acccaatatc tgaggggcct gagagagcca acgaattagt agaatcctat      840

agaaaggctt caaataaagc ttattttgag tggactattg aggccagaga tctttctctg      900

ttgggttccc atgttcgtaa agctacctac cagacttacg ctccacaaac aagcattact      960

ctgacatcca acgcatccgg tacgtttgac ggttactatt acgaactctg gaaggatact     1020

ggcaatacaa caatgacggt ctacactcaa ggtcgctttt cctgccagtg gtcgaacatc     1080

aataacgcgt tgtttaggac cgggaagaaa tacaaccaga attggcagtc tcttggcaca     1140

atccggatca cgtactctgc gacttacaac ccaaacggga actcctactt gtgtatctat     1200

ggctggtcta ccaacccatt ggtcgagttc tacatcgttg agtcctgggg gaactggaga     1260

ccgcctggtg ccacgtccct gggccaagtg acaatcgatg gcgggaccta cgacatctat     1320

aggacgacac gcgtcaacca gccttccatt gtggggacag ccacgttcga tcagtactgg     1380

agcgtgcgca cctctaagcg gacttcagga acagtgaccg tgaccgatca cttccgcgcc     1440

tgggcgaacc ggggcctgaa cctcggcaca atagaccaaa ttacattgtg cgtggagggt     1500

taccaaagct ctggatcagc caacatcacc cagaacacct tctctcgcgg attttatttc     1560

gagttacaag aattgaagga agacgattat tatgggatta ctttatctga tgattctgat     1620

catcagtttt tgcttgccaa ccaggttgtc gtccataatt ctggtgtaaa agttgctgtc     1680

ctcgatacag ggatatccac tcatccagat ctaaatattc gtggtggcgc aagctttgta     1740

ccaggggaac cgtcgactca agatgggaat gggcatggca cgcatgtggc cgggacgatc     1800

gctgctttaa acaattcgat tggcgttctt ggcgtagcgc cgagcgctga gctatacgct     1860

gttaaagtcc taggggcgag cggttcaggt tcggtcagct cgattgccca aggattggaa     1920

tgggcaggga acaatggcat gcacgttgct aatttgagtt taggaagccc ttcgccaagt     1980

gccacacttg agcaagctgt taatagcgcg acttctagag gcgttcttgt tgtagcggca     2040

tctgggaact caggtgcagg ctcaatcagc tatccggcgc gctatgcgaa cgcaatggca     2100

gtcggagcta ctgatcaaaa caacaaccgc gctagctttt cacagtatgg cgcaggcctt     2160

gacattgtcg cacccggggt aaacgtgcag agcacatacc caggttcaac atatgccagc     2220

ttaaacggta catcgatggc tactcctcat gttgcaggtg cggccgccct tgttaaacaa     2280

aagaacccat cttggtctaa tgtacaaatt cgaaatcatc taaagaatac ggcaactagt     2340

ttaggaagca cgaacttgta tggaagcgga cttgttaacg cagaagcggc aacgcgttaa     2400


<210>  702
<211>  2400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS265:mVMA:P77Cd DNA

<400>  702
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actgctttgc caagggtacc aatgttttaa tggcggatgg gtctattgaa      840

tgtattgaaa acattgaggt tggtaataag gtcatgggta aagatggcag acctcgtgag      900

gtaattaaat tgcccagagg aagagaaact atgtacagcg tcgtgcagaa aagtcagcac      960

agagcccaca aaagtgactc aagtcgtgaa gtgccagaat tactcaagtt tacgtgtaat     1020

gcgacccatg agttggttgt tagaacacct cgtagtgtcc gccgtttgtc tcgtaccatt     1080

aagggtgtcg aatattttga agttattact tttgagatgg gccaaaagaa agcccccgac     1140

ggtagaattg ttgagcttgt caaggaagtt tcaaagagct acccaatatc tgaggggcct     1200

gagagagcca acgaattagt agaatcctat agaaaggctt caaataaagc ttattttgag     1260

tggactattg aggccagaga tctttctctg ttgggttccc atgttcgtaa agctacctac     1320

cagacttacg ctccacaaac aagcattact ctgacatcca acgcatccgg tacgtttgac     1380

ggttactatt acgaactctg gaaggatact ggcaatacaa caatgacggt ctacactcaa     1440

ggtcgctttt cctgccagtg gtcgaacatc aataacgcgt tgtttaggac cgggaagaaa     1500

tacaaccaga attggcagtc tcttggcaca atccggatca cgtactctgc gacttacaac     1560

ccaaacggga actcctactt gtgtatctat ggctggtcta ccaacccatt ggtcgagttc     1620

tacatcgttg agtcctgggg gaactggaga ccgcctggtg ccacgtccct gggccaagtg     1680

acaatcgatg gcgggaccta cgacatctat aggacgacac gcgtcaacca gccttccatt     1740

gtggggacag ccacgttcga tcagtactgg agcgtgcgca cctctaagcg gacttcagga     1800

acagtgaccg tgaccgatca cttccgcgcc tgggcgaacc ggggcctgaa cctcggcaca     1860

atagaccaaa ttacattgtg cgtggagggt taccaaagct ctggatcagc caacatcacc     1920

cagaacacct tctctcgcgg attttatttc gagttacaag aattgaagga agacgattat     1980

tatgggatta ctttatctga tgattctgat catcagtttt tgcttgccaa ccaggttgtc     2040

gtccataatt caggtgcagg ctcaatcagc tatccggcgc gctatgcgaa cgcaatggca     2100

gtcggagcta ctgatcaaaa caacaaccgc gctagctttt cacagtatgg cgcaggcctt     2160

gacattgtcg cacccggggt aaacgtgcag agcacatacc caggttcaac atatgccagc     2220

ttaaacggta catcgatggc tactcctcat gttgcaggtg cggccgccct tgttaaacaa     2280

aagaacccat cttggtctaa tgtacaaatt cgaaatcatc taaagaatac ggcaactagt     2340

ttaggaagca cgaacttgta tggaagcgga cttgttaacg cagaagcggc aacgcgttaa     2400


<210>  703
<211>  2400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS269:mVMA:P77Cd DNA

<400>  703
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctgcttt gccaagggta ccaatgtttt aatggcggat      840

gggtctattg aatgtattga aaacattgag gttggtaata aggtcatggg taaagatggc      900

agacctcgtg aggtaattaa attgcccaga ggaagagaaa ctatgtacag cgtcgtgcag      960

aaaagtcagc acagagccca caaaagtgac tcaagtcgtg aagtgccaga attactcaag     1020

tttacgtgta atgcgaccca tgagttggtt gttagaacac ctcgtagtgt ccgccgtttg     1080

tctcgtacca ttaagggtgt cgaatatttt gaagttatta cttttgagat gggccaaaag     1140

aaagcccccg acggtagaat tgttgagctt gtcaaggaag tttcaaagag ctacccaata     1200

tctgaggggc ctgagagagc caacgaatta gtagaatcct atagaaaggc ttcaaataaa     1260

gcttattttg agtggactat tgaggccaga gatctttctc tgttgggttc ccatgttcgt     1320

aaagctacct accagactta cgctccacaa acaagcatta ctctgacatc caacgcatcc     1380

ggtacgtttg acggttacta ttacgaactc tggaaggata ctggcaatac aacaatgacg     1440

gtctacactc aaggtcgctt ttcctgccag tggtcgaaca tcaataacgc gttgtttagg     1500

accgggaaga aatacaacca gaattggcag tctcttggca caatccggat cacgtactct     1560

gcgacttaca acccaaacgg gaactcctac ttgtgtatct atggctggtc taccaaccca     1620

ttggtcgagt tctacatcgt tgagtcctgg gggaactgga gaccgcctgg tgccacgtcc     1680

ctgggccaag tgacaatcga tggcgggacc tacgacatct ataggacgac acgcgtcaac     1740

cagccttcca ttgtggggac agccacgttc gatcagtact ggagcgtgcg cacctctaag     1800

cggacttcag gaacagtgac cgtgaccgat cacttccgcg cctgggcgaa ccggggcctg     1860

aacctcggca caatagacca aattacattg tgcgtggagg gttaccaaag ctctggatca     1920

gccaacatca cccagaacac cttctctcgc ggattttatt tcgagttaca agaattgaag     1980

gaagacgatt attatgggat tactttatct gatgattctg atcatcagtt tttgcttgcc     2040

aaccaggttg tcgtccataa ttcaatcagc tatccggcgc gctatgcgaa cgcaatggca     2100

gtcggagcta ctgatcaaaa caacaaccgc gctagctttt cacagtatgg cgcaggcctt     2160

gacattgtcg cacccggggt aaacgtgcag agcacatacc caggttcaac atatgccagc     2220

ttaaacggta catcgatggc tactcctcat gttgcaggtg cggccgccct tgttaaacaa     2280

aagaacccat cttggtctaa tgtacaaatt cgaaatcatc taaagaatac ggcaactagt     2340

ttaggaagca cgaacttgta tggaagcgga cttgttaacg cagaagcggc aacgcgttaa     2400


<210>  704
<211>  2400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS293:mVMA:P77Cd DNA

<400>  704
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgcttgct ttgccaaggg taccaatgtt      900

ttaatggcgg atgggtctat tgaatgtatt gaaaacattg aggttggtaa taaggtcatg      960

ggtaaagatg gcagacctcg tgaggtaatt aaattgccca gaggaagaga aactatgtac     1020

agcgtcgtgc agaaaagtca gcacagagcc cacaaaagtg actcaagtcg tgaagtgcca     1080

gaattactca agtttacgtg taatgcgacc catgagttgg ttgttagaac acctcgtagt     1140

gtccgccgtt tgtctcgtac cattaagggt gtcgaatatt ttgaagttat tacttttgag     1200

atgggccaaa agaaagcccc cgacggtaga attgttgagc ttgtcaagga agtttcaaag     1260

agctacccaa tatctgaggg gcctgagaga gccaacgaat tagtagaatc ctatagaaag     1320

gcttcaaata aagcttattt tgagtggact attgaggcca gagatctttc tctgttgggt     1380

tcccatgttc gtaaagctac ctaccagact tacgctccac aaacaagcat tactctgaca     1440

tccaacgcat ccggtacgtt tgacggttac tattacgaac tctggaagga tactggcaat     1500

acaacaatga cggtctacac tcaaggtcgc ttttcctgcc agtggtcgaa catcaataac     1560

gcgttgttta ggaccgggaa gaaatacaac cagaattggc agtctcttgg cacaatccgg     1620

atcacgtact ctgcgactta caacccaaac gggaactcct acttgtgtat ctatggctgg     1680

tctaccaacc cattggtcga gttctacatc gttgagtcct gggggaactg gagaccgcct     1740

ggtgccacgt ccctgggcca agtgacaatc gatggcggga cctacgacat ctataggacg     1800

acacgcgtca accagccttc cattgtgggg acagccacgt tcgatcagta ctggagcgtg     1860

cgcacctcta agcggacttc aggaacagtg accgtgaccg atcacttccg cgcctgggcg     1920

aaccggggcc tgaacctcgg cacaatagac caaattacat tgtgcgtgga gggttaccaa     1980

agctctggat cagccaacat cacccagaac accttctctc gcggatttta tttcgagtta     2040

caagaattga aggaagacga ttattatggg attactttat ctgatgattc tgatcatcag     2100

tttttgcttg ccaaccaggt tgtcgtccat aatagctttt cacagtatgg cgcaggcctt     2160

gacattgtcg cacccggggt aaacgtgcag agcacatacc caggttcaac atatgccagc     2220

ttaaacggta catcgatggc tactcctcat gttgcaggtg cggccgccct tgttaaacaa     2280

aagaacccat cttggtctaa tgtacaaatt cgaaatcatc taaagaatac ggcaactagt     2340

ttaggaagca cgaacttgta tggaagcgga cttgttaacg cagaagcggc aacgcgttaa     2400


<210>  705
<211>  2400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS312:mVMA:P77Cd DNA

<400>  705
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagtgctttg ccaagggtac caatgtttta      960

atggcggatg ggtctattga atgtattgaa aacattgagg ttggtaataa ggtcatgggt     1020

aaagatggca gacctcgtga ggtaattaaa ttgcccagag gaagagaaac tatgtacagc     1080

gtcgtgcaga aaagtcagca cagagcccac aaaagtgact caagtcgtga agtgccagaa     1140

ttactcaagt ttacgtgtaa tgcgacccat gagttggttg ttagaacacc tcgtagtgtc     1200

cgccgtttgt ctcgtaccat taagggtgtc gaatattttg aagttattac ttttgagatg     1260

ggccaaaaga aagcccccga cggtagaatt gttgagcttg tcaaggaagt ttcaaagagc     1320

tacccaatat ctgaggggcc tgagagagcc aacgaattag tagaatccta tagaaaggct     1380

tcaaataaag cttattttga gtggactatt gaggccagag atctttctct gttgggttcc     1440

catgttcgta aagctaccta ccagacttac gctccacaaa caagcattac tctgacatcc     1500

aacgcatccg gtacgtttga cggttactat tacgaactct ggaaggatac tggcaataca     1560

acaatgacgg tctacactca aggtcgcttt tcctgccagt ggtcgaacat caataacgcg     1620

ttgtttagga ccgggaagaa atacaaccag aattggcagt ctcttggcac aatccggatc     1680

acgtactctg cgacttacaa cccaaacggg aactcctact tgtgtatcta tggctggtct     1740

accaacccat tggtcgagtt ctacatcgtt gagtcctggg ggaactggag accgcctggt     1800

gccacgtccc tgggccaagt gacaatcgat ggcgggacct acgacatcta taggacgaca     1860

cgcgtcaacc agccttccat tgtggggaca gccacgttcg atcagtactg gagcgtgcgc     1920

acctctaagc ggacttcagg aacagtgacc gtgaccgatc acttccgcgc ctgggcgaac     1980

cggggcctga acctcggcac aatagaccaa attacattgt gcgtggaggg ttaccaaagc     2040

tctggatcag ccaacatcac ccagaacacc ttctctcgcg gattttattt cgagttacaa     2100

gaattgaagg aagacgatta ttatgggatt actttatctg atgattctga tcatcagttt     2160

ttgcttgcca accaggttgt cgtccataat agcacatacc caggttcaac atatgccagc     2220

ttaaacggta catcgatggc tactcctcat gttgcaggtg cggccgccct tgttaaacaa     2280

aagaacccat cttggtctaa tgtacaaatt cgaaatcatc taaagaatac ggcaactagt     2340

ttaggaagca cgaacttgta tggaagcgga cttgttaacg cagaagcggc aacgcgttaa     2400


<210>  706
<211>  2400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS317:mVMA:P77Cd DNA

<400>  706
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggttg ctttgccaag      960

ggtaccaatg ttttaatggc ggatgggtct attgaatgta ttgaaaacat tgaggttggt     1020

aataaggtca tgggtaaaga tggcagacct cgtgaggtaa ttaaattgcc cagaggaaga     1080

gaaactatgt acagcgtcgt gcagaaaagt cagcacagag cccacaaaag tgactcaagt     1140

cgtgaagtgc cagaattact caagtttacg tgtaatgcga cccatgagtt ggttgttaga     1200

acacctcgta gtgtccgccg tttgtctcgt accattaagg gtgtcgaata ttttgaagtt     1260

attacttttg agatgggcca aaagaaagcc cccgacggta gaattgttga gcttgtcaag     1320

gaagtttcaa agagctaccc aatatctgag gggcctgaga gagccaacga attagtagaa     1380

tcctatagaa aggcttcaaa taaagcttat tttgagtgga ctattgaggc cagagatctt     1440

tctctgttgg gttcccatgt tcgtaaagct acctaccaga cttacgctcc acaaacaagc     1500

attactctga catccaacgc atccggtacg tttgacggtt actattacga actctggaag     1560

gatactggca atacaacaat gacggtctac actcaaggtc gcttttcctg ccagtggtcg     1620

aacatcaata acgcgttgtt taggaccggg aagaaataca accagaattg gcagtctctt     1680

ggcacaatcc ggatcacgta ctctgcgact tacaacccaa acgggaactc ctacttgtgt     1740

atctatggct ggtctaccaa cccattggtc gagttctaca tcgttgagtc ctgggggaac     1800

tggagaccgc ctggtgccac gtccctgggc caagtgacaa tcgatggcgg gacctacgac     1860

atctatagga cgacacgcgt caaccagcct tccattgtgg ggacagccac gttcgatcag     1920

tactggagcg tgcgcacctc taagcggact tcaggaacag tgaccgtgac cgatcacttc     1980

cgcgcctggg cgaaccgggg cctgaacctc ggcacaatag accaaattac attgtgcgtg     2040

gagggttacc aaagctctgg atcagccaac atcacccaga acaccttctc tcgcggattt     2100

tatttcgagt tacaagaatt gaaggaagac gattattatg ggattacttt atctgatgat     2160

tctgatcatc agtttttgct tgccaaccag gttgtcgtcc ataattcaac atatgccagc     2220

ttaaacggta catcgatggc tactcctcat gttgcaggtg cggccgccct tgttaaacaa     2280

aagaacccat cttggtctaa tgtacaaatt cgaaatcatc taaagaatac ggcaactagt     2340

ttaggaagca cgaacttgta tggaagcgga cttgttaacg cagaagcggc aacgcgttaa     2400


<210>  707
<211>  2400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, iproSavS326:mVMA:P77Cd DNA

<400>  707
atgaagaaac cgttggggaa aattgtcgca agcaccgcac tactcatttc tgttgctttt       60

agttcatcga tcgcatcggc tgctgaagaa gcaaaagaaa aatatttaat tggctttaat      120

gagcaggaag ctgtcagtga gtttgtagaa caagtagagg caaatgacga ggtcgccatt      180

ctctctgagg aagaggaagt cgaaattgaa ttgcttcatg aatttgaaac gattcctgtt      240

ttatccgttg agttaagccc agaagatgtg gacgcgcttg aactcgatcc agcgatttct      300

tatattgaag aggatgcaga agtaacgaca atggcgcaat cggtaccatg gggaattagc      360

cgtgtgcaag ccccagctgc ccataaccgt ggattgacag gttctggtgt aaaagttgct      420

gtcctcgata cagggatatc cactcatcca gatctaaata ttcgtggtgg cgcaagcttt      480

gtaccagggg aaccgtcgac tcaagatggg aatgggcatg gcacgcatgt ggccgggacg      540

atcgctgctt taaacaattc gattggcgtt cttggcgtag cgccgagcgc tgagctatac      600

gctgttaaag tcctaggggc gagcggttca ggttcggtca gctcgattgc ccaaggattg      660

gaatgggcag ggaacaatgg catgcacgtt gctaatttga gtttaggaag cccttcgcca      720

agtgccacac ttgagcaagc tgttaatagc gcgacttcta gaggcgttct tgttgtagcg      780

gcatctggga actcaggtgc aggctcaatc agctatccgg cgcgctatgc gaacgcaatg      840

gcagtcggag ctactgatca aaacaacaac cgcgctagct tttcacagta tggcgcaggc      900

cttgacattg tcgcacccgg ggtaaacgtg cagagcacat acccaggttc aacatatgcc      960

agcttaaacg gtacatgctt tgccaagggt accaatgttt taatggcgga tgggtctatt     1020

gaatgtattg aaaacattga ggttggtaat aaggtcatgg gtaaagatgg cagacctcgt     1080

gaggtaatta aattgcccag aggaagagaa actatgtaca gcgtcgtgca gaaaagtcag     1140

cacagagccc acaaaagtga ctcaagtcgt gaagtgccag aattactcaa gtttacgtgt     1200

aatgcgaccc atgagttggt tgttagaaca cctcgtagtg tccgccgttt gtctcgtacc     1260

attaagggtg tcgaatattt tgaagttatt acttttgaga tgggccaaaa gaaagccccc     1320

gacggtagaa ttgttgagct tgtcaaggaa gtttcaaaga gctacccaat atctgagggg     1380

cctgagagag ccaacgaatt agtagaatcc tatagaaagg cttcaaataa agcttatttt     1440

gagtggacta ttgaggccag agatctttct ctgttgggtt cccatgttcg taaagctacc     1500

taccagactt acgctccaca aacaagcatt actctgacat ccaacgcatc cggtacgttt     1560

gacggttact attacgaact ctggaaggat actggcaata caacaatgac ggtctacact     1620

caaggtcgct tttcctgcca gtggtcgaac atcaataacg cgttgtttag gaccgggaag     1680

aaatacaacc agaattggca gtctcttggc acaatccgga tcacgtactc tgcgacttac     1740

aacccaaacg ggaactccta cttgtgtatc tatggctggt ctaccaaccc attggtcgag     1800

ttctacatcg ttgagtcctg ggggaactgg agaccgcctg gtgccacgtc cctgggccaa     1860

gtgacaatcg atggcgggac ctacgacatc tataggacga cacgcgtcaa ccagccttcc     1920

attgtgggga cagccacgtt cgatcagtac tggagcgtgc gcacctctaa gcggacttca     1980

ggaacagtga ccgtgaccga tcacttccgc gcctgggcga accggggcct gaacctcggc     2040

acaatagacc aaattacatt gtgcgtggag ggttaccaaa gctctggatc agccaacatc     2100

acccagaaca ccttctctcg cggattttat ttcgagttac aagaattgaa ggaagacgat     2160

tattatggga ttactttatc tgatgattct gatcatcagt ttttgcttgc caaccaggtt     2220

gtcgtccata attcgatggc tactcctcat gttgcaggtg cggccgccct tgttaaacaa     2280

aagaacccat cttggtctaa tgtacaaatt cgaaatcatc taaagaatac ggcaactagt     2340

ttaggaagca cgaacttgta tggaagcgga cttgttaacg cagaagcggc aacgcgttaa     2400


<210>  708
<211>  2070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS135:mTth:P77Cd

<400>  708
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttgcctg gccgagggct cgctcgtctt ggacgcggct      360

accgggcaga gggtccctat cgaaaaggtg cgtccgggga tggaagtttt ctccttggga      420

cctgattaca gactgtatcg ggtgcccgtt ttggaggtcc ttgagagcgg ggttagggaa      480

gttgtgcgcc tcagaactcg gtcagggaga acgctggtgt tgacaccaga tcacccgctt      540

ttgacccccg aaggttggaa acctctttgt gacctcccgc ttggaactcc aattgcagtc      600

caaacaagca ttactctgac atccaacgca tccggtacgt ttgacggtta ctattacgaa      660

ctctggaagg atactggcaa tacaacaatg acggtctaca ctcaaggtcg cttttcctgc      720

cagtggtcga acatcaataa cgcgttgttt aggaccggga agaaatacaa ccagaattgg      780

cagtctcttg gcacaatccg gatcacgtac tctgcgactt acaacccaaa cgggaactcc      840

tacttgtgta tctatggctg gtctaccaac ccattggtcg agttctacat cgttgagtcc      900

tgggggaact ggagaccgcc tggtgccacg tccctgggcc aagtgacaat cgatggcggg      960

acctacgaca tctataggac gacacgcgtc aaccagcctt ccattgtggg gacagccacg     1020

ttcgatcagt actggagcgt gcgcacctct aagcggactt caggaacagt gaccgtgacc     1080

gatcacttcc gcgcctgggc gaaccggggc ctgaacctcg gcacaataga ccaaattaca     1140

ttgtgcgtgg agggttacca aagctctgga tcagccaaca tcacccagaa caccttctct     1200

agagatgttg agactggaga ggttctctgg gaccctattg ttgctgtcga accggccggt     1260

aaggcgagaa cattcgactt gcgcgttcca ccctttgcaa acttcgtgag cgaggacctg     1320

gtggtgcata actctggtgt aaaagttgct gtcctcgata cagggatatc cactcatcca     1380

gatctaaata ttcgtggtgg cgcaagcttt gtaccagggg aaccgtcgac tcaagatggg     1440

aatgggcatg gcacgcatgt ggccgggacg atcgctgctt taaacaattc gattggcgtt     1500

cttggcgtag cgccgagcgc tgagctatac gctgttaaag tcctaggggc gagcggttca     1560

ggttcggtca gctcgattgc ccaaggattg gaatgggcag ggaacaatgg catgcacgtt     1620

gctaatttga gtttaggaag cccttcgcca agtgccacac ttgagcaagc tgttaatagc     1680

gcgacttcta gaggcgttct tgttgtagcg gcatctggga actcaggtgc aggctcaatc     1740

agctatccgg cgcgctatgc gaacgcaatg gcagtcggag ctactgatca aaacaacaac     1800

cgcgctagct tttcacagta tggcgcaggc cttgacattg tcgcacccgg ggtaaacgtg     1860

cagagcacat acccaggttc aacttatgcc agcttaaacg gtacatcgat ggctactcct     1920

catgttgcag gtgcggccgc ccttgttaaa caaaagaacc catcttggtc taatgtacaa     1980

attcgaaatc atctaaagaa tacggcaact agtttaggaa gcacgaactt gtatggaagc     2040

ggacttgtta acgcagaagc ggcaacgcgt                                      2070


<210>  709
<211>  2070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS269:mTth:P77Cd

<400>  709
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctgcc tggccgaggg ctcgctcgtc ttggacgcgg ctaccgggca gagggtccct      780

atcgaaaagg tgcgtccggg gatggaagtt ttctccttgg gacctgatta cagactgtat      840

cgggtgcccg ttttggaggt ccttgagagc ggggttaggg aagttgtgcg cctcagaact      900

cggtcaggga gaacgctggt gttgacacca gatcacccgc ttttgacccc cgaaggttgg      960

aaacctcttt gtgacctccc gcttggaact ccaattgcag tccaaacaag cattactctg     1020

acatccaacg catccggtac gtttgacggt tactattacg aactctggaa ggatactggc     1080

aatacaacaa tgacggtcta cactcaaggt cgcttttcct gccagtggtc gaacatcaat     1140

aacgcgttgt ttaggaccgg gaagaaatac aaccagaatt ggcagtctct tggcacaatc     1200

cggatcacgt actctgcgac ttacaaccca aacgggaact cctacttgtg tatctatggc     1260

tggtctacca acccattggt cgagttctac atcgttgagt cctgggggaa ctggagaccg     1320

cctggtgcca cgtccctggg ccaagtgaca atcgatggcg ggacctacga catctatagg     1380

acgacacgcg tcaaccagcc ttccattgtg gggacagcca cgttcgatca gtactggagc     1440

gtgcgcacct ctaagcggac ttcaggaaca gtgaccgtga ccgatcactt ccgcgcctgg     1500

gcgaaccggg gcctgaacct cggcacaata gaccaaatta cattgtgcgt ggagggttac     1560

caaagctctg gatcagccaa catcacccag aacaccttct ctagagatgt tgagactgga     1620

gaggttctct gggaccctat tgttgctgtc gaaccggccg gtaaggcgag aacattcgac     1680

ttgcgcgttc caccctttgc aaacttcgtg agcgaggacc tggtggtgca taactcaatc     1740

agctatccgg cgcgctatgc gaacgcaatg gcagtcggag ctactgatca aaacaacaac     1800

cgcgctagct tttcacagta tggcgcaggc cttgacattg tcgcacccgg ggtaaacgtg     1860

cagagcacat acccaggttc aacttatgcc agcttaaacg gtacatcgat ggctactcct     1920

catgttgcag gtgcggccgc ccttgttaaa caaaagaacc catcttggtc taatgtacaa     1980

attcgaaatc atctaaagaa tacggcaact agtttaggaa gcacgaactt gtatggaagc     2040

ggacttgtta acgcagaagc ggcaacgcgt                                      2070


<210>  710
<211>  2070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS293:mTth:P77Cd

<400>  710
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgcttg cctggccgag ggctcgctcg tcttggacgc ggctaccggg      840

cagagggtcc ctatcgaaaa ggtgcgtccg gggatggaag ttttctcctt gggacctgat      900

tacagactgt atcgggtgcc cgttttggag gtccttgaga gcggggttag ggaagttgtg      960

cgcctcagaa ctcggtcagg gagaacgctg gtgttgacac cagatcaccc gcttttgacc     1020

cccgaaggtt ggaaacctct ttgtgacctc ccgcttggaa ctccaattgc agtccaaaca     1080

agcattactc tgacatccaa cgcatccggt acgtttgacg gttactatta cgaactctgg     1140

aaggatactg gcaatacaac aatgacggtc tacactcaag gtcgcttttc ctgccagtgg     1200

tcgaacatca ataacgcgtt gtttaggacc gggaagaaat acaaccagaa ttggcagtct     1260

cttggcacaa tccggatcac gtactctgcg acttacaacc caaacgggaa ctcctacttg     1320

tgtatctatg gctggtctac caacccattg gtcgagttct acatcgttga gtcctggggg     1380

aactggagac cgcctggtgc cacgtccctg ggccaagtga caatcgatgg cgggacctac     1440

gacatctata ggacgacacg cgtcaaccag ccttccattg tggggacagc cacgttcgat     1500

cagtactgga gcgtgcgcac ctctaagcgg acttcaggaa cagtgaccgt gaccgatcac     1560

ttccgcgcct gggcgaaccg gggcctgaac ctcggcacaa tagaccaaat tacattgtgc     1620

gtggagggtt accaaagctc tggatcagcc aacatcaccc agaacacctt ctctagagat     1680

gttgagactg gagaggttct ctgggaccct attgttgctg tcgaaccggc cggtaaggcg     1740

agaacattcg acttgcgcgt tccacccttt gcaaacttcg tgagcgagga cctggtggtg     1800

cataacagct tttcacagta tggcgcaggc cttgacattg tcgcacccgg ggtaaacgtg     1860

cagagcacat acccaggttc aacttatgcc agcttaaacg gtacatcgat ggctactcct     1920

catgttgcag gtgcggccgc ccttgttaaa caaaagaacc catcttggtc taatgtacaa     1980

attcgaaatc atctaaagaa tacggcaact agtttaggaa gcacgaactt gtatggaagc     2040

ggacttgtta acgcagaagc ggcaacgcgt                                      2070


<210>  711
<211>  2070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS317:mTth:P77Cd

<400>  711
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tgcctggccg agggctcgct cgtcttggac      900

gcggctaccg ggcagagggt ccctatcgaa aaggtgcgtc cggggatgga agttttctcc      960

ttgggacctg attacagact gtatcgggtg cccgttttgg aggtccttga gagcggggtt     1020

agggaagttg tgcgcctcag aactcggtca gggagaacgc tggtgttgac accagatcac     1080

ccgcttttga cccccgaagg ttggaaacct ctttgtgacc tcccgcttgg aactccaatt     1140

gcagtccaaa caagcattac tctgacatcc aacgcatccg gtacgtttga cggttactat     1200

tacgaactct ggaaggatac tggcaataca acaatgacgg tctacactca aggtcgcttt     1260

tcctgccagt ggtcgaacat caataacgcg ttgtttagga ccgggaagaa atacaaccag     1320

aattggcagt ctcttggcac aatccggatc acgtactctg cgacttacaa cccaaacggg     1380

aactcctact tgtgtatcta tggctggtct accaacccat tggtcgagtt ctacatcgtt     1440

gagtcctggg ggaactggag accgcctggt gccacgtccc tgggccaagt gacaatcgat     1500

ggcgggacct acgacatcta taggacgaca cgcgtcaacc agccttccat tgtggggaca     1560

gccacgttcg atcagtactg gagcgtgcgc acctctaagc ggacttcagg aacagtgacc     1620

gtgaccgatc acttccgcgc ctgggcgaac cggggcctga acctcggcac aatagaccaa     1680

attacattgt gcgtggaggg ttaccaaagc tctggatcag ccaacatcac ccagaacacc     1740

ttctctagag atgttgagac tggagaggtt ctctgggacc ctattgttgc tgtcgaaccg     1800

gccggtaagg cgagaacatt cgacttgcgc gttccaccct ttgcaaactt cgtgagcgag     1860

gacctggtgg tgcataactc aacttatgcc agcttaaacg gtacatcgat ggctactcct     1920

catgttgcag gtgcggccgc ccttgttaaa caaaagaacc catcttggtc taatgtacaa     1980

attcgaaatc atctaaagaa tacggcaact agtttaggaa gcacgaactt gtatggaagc     2040

ggacttgtta acgcagaagc ggcaacgcgt                                      2070


<210>  712
<211>  2388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS312:mVMA-c:P77Cd

<400>  712
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcaggcctt tgccaagggt accaatgttt taatggcgga tgggtctatt      900

gaatgtattg aaaacattga ggttggtaat aaggtcatgg gtaaagatgg cagacctcgt      960

gaggtaatta aattgcccag aggaagagaa actatgtaca gcgtcgtgca gaaaagtcag     1020

cacagagccc acaaaagtga ctcaagtcgt gaagtgccag aattactcaa gtttacgtgt     1080

aatgcgaccc atgagttggt tgttagaaca cctcgtagtg tccgccgttt gtctcgtacc     1140

attaagggtg tcgaatattt tgaagttatt acttttgaga tgggccaaaa gaaagccccc     1200

gacggtagaa ttgttgagct tgtcaaggaa gtttcaaaga gctacccaat atctgagggg     1260

cctgagagag ccaacgaatt agtagaatcc tatagaaagg cttcaaataa agcttatttt     1320

gagtggacta ttgaggccag agatctttct ctgttgggtt cccatgttcg taaagctacc     1380

taccagactt acgctccatt ccttaagaaa ctgtctaagt tgctgctcgt cgtgctcctt     1440

gttgccgttt acacacaggt caacgcgcaa acaagcatta ctctgacatc caacgcatcc     1500

ggtacgtttg acggttacta ttacgaactc tggaaggata ctggcaatac aacaatgacg     1560

gtctacactc aaggtcgctt ttcctgccag tggtcgaaca tcaataacgc gttgtttagg     1620

accgggaaga aatacaacca gaattggcag tctcttggca caatccggat cacgtactct     1680

gcgacttaca acccaaacgg gaactcctac ttgtgtatct atggctggtc taccaaccca     1740

ttggtcgagt tctacatcgt tgagtcctgg gggaactgga gaccgcctgg tgccacgtcc     1800

ctgggccaag tgacaatcga tggcgggacc tacgacatct ataggacgac acgcgtcaac     1860

cagccttcca ttgtggggac agccacgttc gatcagtact ggagcgtgcg cacctctaag     1920

cggacttcag gaacagtgac cgtgaccgat cacttccgcg cctgggcgaa ccggggcctg     1980

aacctcggca caatagacca aattacattg tgcgtggagg gttaccaaag ctctggatca     2040

gccaacatca cccagaacac cttctctcgc ggattttatt tcgagttaca agaattgaag     2100

gaagacgatt attatgggat tactttatct gatgattctg atcatcagtt tttgcttgcc     2160

aaccaggttg tcgtccatgc cagcacatac ccaggttcaa cttatgccag cttaaacggt     2220

acatcgatgg ctactcctca tgttgcaggt gcggccgccc ttgttaaaca aaagaaccca     2280

tcttggtcta atgtacaaat tcgaaatcat ctaaagaata cggcaactag tttaggaagc     2340

acgaacttgt atggaagcgg acttgttaac gcagaagcgg caacgcgt                  2388


<210>  713
<211>  2388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct iproSavS326:mVMA-c:P77Cd

<400>  713
atggctgaag aagcaaaaga aaaatattta attggcttta atgagcagga agctgtcagt       60

gagtttgtag aacaagtaga ggcaaatgac gaggtcgcca ttctctctga ggaagaggaa      120

gtcgaaattg aattgcttca tgaatttgaa acgattcctg ttttatccgt tgagttaagc      180

ccagaagatg tggacgcgct tgaactcgat ccagcgattt cttatattga agaggatgca      240

gaagtaacga caatggcgca atcggtacct tggggaatta gccgtgtgca agccccagct      300

gcccataacc gtggattgac aggttctggt gtaaaagttg ctgtcctcga tacagggata      360

tccactcatc cagatctaaa tattcgtggt ggcgcaagct ttgtaccagg ggaaccgtcg      420

actcaagatg ggaatgggca tggcacgcat gtggccggga cgatcgctgc tttaaacaat      480

tcgattggcg ttcttggcgt agcgccgagc gctgagctat acgctgttaa agtcctaggg      540

gcgagcggtt caggttcggt cagctcgatt gcccaaggat tggaatgggc agggaacaat      600

ggcatgcacg ttgctaattt gagtttagga agcccttcgc caagtgccac acttgagcaa      660

gctgttaata gcgcgacttc tagaggcgtt cttgttgtag cggcatctgg gaactcaggt      720

gcaggctcaa tcagctatcc ggcgcgctat gcgaacgcaa tggcagtcgg agctactgat      780

caaaacaaca accgcgctag cttttcacag tatggcgcag gccttgacat tgtcgcaccc      840

ggggtaaacg tgcagagcac atacccaggt tcaacttatg ccagcttaaa cggtacagcc      900

tttgccaagg gtaccaatgt tttaatggcg gatgggtcta ttgaatgtat tgaaaacatt      960

gaggttggta ataaggtcat gggtaaagat ggcagacctc gtgaggtaat taaattgccc     1020

agaggaagag aaactatgta cagcgtcgtg cagaaaagtc agcacagagc ccacaaaagt     1080

gactcaagtc gtgaagtgcc agaattactc aagtttacgt gtaatgcgac ccatgagttg     1140

gttgttagaa cacctcgtag tgtccgccgt ttgtctcgta ccattaaggg tgtcgaatat     1200

tttgaagtta ttacttttga gatgggccaa aagaaagccc ccgacggtag aattgttgag     1260

cttgtcaagg aagtttcaaa gagctaccca atatctgagg ggcctgagag agccaacgaa     1320

ttagtagaat cctatagaaa ggcttcaaat aaagcttatt ttgagtggac tattgaggcc     1380

agagatcttt ctctgttggg ttcccatgtt cgtaaagcta cctaccagac ttacgctcca     1440

ttccttaaga aactgtctaa gttgctgctc gtcgtgctcc ttgttgccgt ttacacacag     1500

gtcaacgcgc aaacaagcat tactctgaca tccaacgcat ccggtacgtt tgacggttac     1560

tattacgaac tctggaagga tactggcaat acaacaatga cggtctacac tcaaggtcgc     1620

ttttcctgcc agtggtcgaa catcaataac gcgttgttta ggaccgggaa gaaatacaac     1680

cagaattggc agtctcttgg cacaatccgg atcacgtact ctgcgactta caacccaaac     1740

gggaactcct acttgtgtat ctatggctgg tctaccaacc cattggtcga gttctacatc     1800

gttgagtcct gggggaactg gagaccgcct ggtgccacgt ccctgggcca agtgacaatc     1860

gatggcggga cctacgacat ctataggacg acacgcgtca accagccttc cattgtgggg     1920

acagccacgt tcgatcagta ctggagcgtg cgcacctcta agcggacttc aggaacagtg     1980

accgtgaccg atcacttccg cgcctgggcg aaccggggcc tgaacctcgg cacaatagac     2040

caaattacat tgtgcgtgga gggttaccaa agctctggat cagccaacat cacccagaac     2100

accttctctc gcggatttta tttcgagtta caagaattga aggaagacga ttattatggg     2160

attactttat ctgatgattc tgatcatcag tttttgcttg ccaaccaggt tgtcgtccat     2220

gcctcgatgg ctactcctca tgttgcaggt gcggccgccc ttgttaaaca aaagaaccca     2280

tcttggtcta atgtacaaat tcgaaatcat ctaaagaata cggcaactag tttaggaagc     2340

acgaacttgt atggaagcgg acttgttaac gcagaagcgg caacgcgt                  2388


<210>  714
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, P77853Cd protein

<400>  714

Met Gln Thr Ser Ile Thr Leu Thr Ser Asn Ala Ser Gly Thr Phe Asp 
1               5                   10                  15      


Gly Tyr Tyr Tyr Glu Leu Trp Lys Asp Thr Gly Asn Thr Thr Met Thr 
            20                  25                  30          


Val Tyr Thr Gln Gly Arg Phe Ser Cys Gln Trp Ser Asn Ile Asn Asn 
        35                  40                  45              


Ala Leu Phe Arg Thr Gly Lys Lys Tyr Asn Gln Asn Trp Gln Ser Leu 
    50                  55                  60                  


Gly Thr Ile Arg Ile Thr Tyr Ser Ala Thr Tyr Asn Pro Asn Gly Asn 
65                  70                  75                  80  


Ser Tyr Leu Cys Ile Tyr Gly Trp Ser Thr Asn Pro Leu Val Glu Phe 
                85                  90                  95      


Tyr Ile Val Glu Ser Trp Gly Asn Trp Arg Pro Pro Gly Ala Thr Ser 
            100                 105                 110         


Leu Gly Gln Val Thr Ile Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Thr 
        115                 120                 125             


Thr Arg Val Asn Gln Pro Ser Ile Val Gly Thr Ala Thr Phe Asp Gln 
    130                 135                 140                 


Tyr Trp Ser Val Arg Thr Ser Lys Arg Thr Ser Gly Thr Val Thr Val 
145                 150                 155                 160 


Thr Asp His Phe Arg Ala Trp Ala Asn Arg Gly Leu Asn Leu Gly Thr 
                165                 170                 175     


Ile Asp Gln Ile Thr Leu Cys Val Glu Gly Tyr Gln Ser Ser Gly Ser 
            180                 185                 190         


Ala Asn Ile Thr Gln Asn Thr Phe Ser 
        195                 200     


<210>  715
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, EU591743 protein

<400>  715

Met Phe Tyr Ser Phe Trp Lys Asp Ser Pro Gly Thr Val Asn Phe Cys 
1               5                   10                  15      


Leu Leu Glu Gly Gly Arg Tyr Thr Ser Asn Trp Ser Gly Ile Asn Asn 
            20                  25                  30          


Trp Val Gly Gly Lys Gly Trp Gln Thr Gly Ser Arg Arg Asn Ile Thr 
        35                  40                  45              


Tyr Ser Gly Ser Phe Asn Thr Pro Gly Asn Gly Tyr Leu Ala Leu Tyr 
    50                  55                  60                  


Gly Trp Thr Thr Asn Pro Leu Val Glu Tyr Tyr Val Val Asp Ser Trp 
65                  70                  75                  80  


Gly Ser Trp Arg Pro Pro Gly Ser Asp Gly Thr Phe Leu Gly Thr Val 
                85                  90                  95      


Asn Ser Asp Gly Gly Thr Tyr Asp Ile Tyr Arg Ala Gln Arg Val Asn 
            100                 105                 110         


Ala Pro Ser Ile Ile Gly Asn Ala Thr Phe Tyr Gln Tyr Trp Ser Val 
        115                 120                 125             


Arg Gln Ser Lys Arg Val Gly Gly Thr Ile Thr Thr Gly Asn His Phe 
    130                 135                 140                 


Asp Ala Trp Ala Ser Val Gly Leu Asn Leu Gly Thr His Asn Tyr Gln 
145                 150                 155                 160 


Ile Met Ala Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser Asp Ile Thr 
                165                 170                 175     


Val Ser 
        


<210>  716
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, P77853cd (P77Cd) DNA

<400>  716
atgcaaacaa gcattactct gacatccaac gcatccggta cgtttgacgg ttactattac       60

gaactctgga aggatactgg caatacaaca atgacggtct acactcaagg tcgcttttcc      120

tgccagtggt cgaacatcaa taacgcgttg tttaggaccg ggaagaaata caaccagaat      180

tggcagtctc ttggcacaat ccggatcacg tactctgcga cttacaaccc aaacgggaac      240

tcctacttgt gtatctatgg ctggtctacc aacccattgg tcgagttcta catcgttgag      300

tcctggggga actggagacc gcctggtgcc acgtccctgg gccaagtgac aatcgatggc      360

gggacctacg acatctatag gacgacacgc gtcaaccagc cttccattgt ggggacagcc      420

acgttcgatc agtactggag cgtgcgcacc tctaagcgga cttcaggaac agtgaccgtg      480

accgatcact tccgcgcctg ggcgaaccgg ggcctgaacc tcggcacaat agaccaaatt      540

acattgtgcg tggagggtta ccaaagctct ggatcagcca acatcaccca gaacaccttc      600

tcttag                                                                 606


<210>  717
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, EU591743 (EU59) DNA

<400>  717
atgttttact cgttttggaa agattctcct ggtactgtta acttttgcct tcttgaaggg       60

ggaagatata cctccaattg gtctgggata aacaattggg tcggtggcaa gggctggcag      120

accggtagta ggcgcaacat cacgtattcc gggagcttca atacaccagg gaatggatac      180

ctggctctct acggttggac caccaacccg ttggttgagt actatgttgt cgatagctgg      240

ggctcctggc gccctcccgg aagtgatggg acatttcttg gcacagtgaa ctcagacggc      300

ggcacgtatg acatctacag ggcgcaaaga gtcaacgcac cgagcatcat tggcaatgcc      360

accttctacc agtattggtc cgtgcggcag tccaagcgtg tcggtgggac aatcacgact      420

ggcaaccact tcgacgcgtg ggccagcgtg ggcctcaacc tcgggactca taactaccag      480

ataatggcta ctgagggtta ccagtcgtca ggatcttcag acattacggt gtcatga         537


<210>  718
<211>  409
<212>  PRT
<213>  Trichoderma reesei


<220>
<221>  MISC_FEATURE
<222>  (1)..(409)
<223>  Acid fungal protease

<400>  718

Met Gln Thr Phe Gly Ala Phe Leu Val Ser Phe Leu Ala Ala Ser Gly 
1               5                   10                  15      


Leu Ala Ala Ala Leu Leu Pro Thr Glu Gly Gln Lys Thr Ala Ser Val 
            20                  25                  30          


Glu Val Gln Tyr Asn Lys Asn Tyr Val Pro His Gly Pro Thr Ala Leu 
        35                  40                  45              


Phe Lys Ala Lys Arg Lys Tyr Gly Ala Pro Ile Ser Asp Asn Leu Lys 
    50                  55                  60                  


Ser Leu Val Ala Ala Arg Gln Ala Lys Gln Ala Leu Ala Lys Arg Gln 
65                  70                  75                  80  


Thr Gly Ser Ala Pro Asn His Pro Ser Asp Ser Ala Asp Ser Glu Tyr 
                85                  90                  95      


Ile Thr Ser Val Ser Ile Gly Thr Pro Ala Gln Val Leu Pro Leu Asp 
            100                 105                 110         


Phe Asp Thr Gly Ser Ser Asp Leu Trp Val Phe Ser Ser Glu Thr Pro 
        115                 120                 125             


Lys Ser Ser Ala Thr Gly His Ala Ile Tyr Thr Pro Ser Lys Ser Ser 
    130                 135                 140                 


Thr Ser Lys Lys Val Ser Gly Ala Ser Trp Ser Ile Ser Tyr Gly Asp 
145                 150                 155                 160 


Gly Ser Ser Ser Ser Gly Asp Val Tyr Thr Asp Lys Val Thr Ile Gly 
                165                 170                 175     


Gly Phe Ser Val Asn Thr Gln Gly Val Glu Ser Ala Thr Arg Val Ser 
            180                 185                 190         


Thr Glu Phe Val Gln Asp Thr Val Ile Ser Gly Leu Val Gly Leu Ala 
        195                 200                 205             


Phe Asp Ser Gly Asn Gln Val Arg Pro His Pro Gln Lys Thr Trp Phe 
    210                 215                 220                 


Ser Asn Ala Ala Ser Ser Leu Ala Glu Pro Leu Phe Thr Ala Asp Leu 
225                 230                 235                 240 


Arg His Gly Gln Asn Gly Ser Tyr Asn Phe Gly Tyr Ile Asp Thr Ser 
                245                 250                 255     


Val Ala Lys Gly Pro Val Ala Tyr Thr Pro Val Asp Asn Ser Gln Gly 
            260                 265                 270         


Phe Trp Glu Phe Thr Ala Ser Gly Tyr Ser Val Gly Gly Gly Lys Leu 
        275                 280                 285             


Asn Arg Asn Ser Ile Asp Gly Ile Ala Asp Thr Gly Thr Thr Leu Leu 
    290                 295                 300                 


Leu Leu Leu Asp Asp Asn Val Val Asp Ala Tyr Tyr Ala Asn Val Gln 
305                 310                 315                 320 


Ser Ala Gln Tyr Asp Asn Gln Gln Glu Gly Val Val Phe Asp Cys Asp 
                325                 330                 335     


Glu Asp Leu Pro Ser Phe Ser Phe Gly Val Gly Ser Ser Thr Ile Thr 
            340                 345                 350         


Ile Pro Gly Asp Leu Leu Asn Leu Thr Pro Leu Glu Glu Gly Ser Ser 
        355                 360                 365             


Thr Cys Phe Gly Gly Leu Gln Ser Ser Ser Gly Ile Gly Ile Asn Ile 
    370                 375                 380                 


Phe Gly Asp Val Ala Leu Lys Ala Ala Leu Val Val Phe Asp Leu Gly 
385                 390                 395                 400 


Asn Glu Arg Leu Gly Trp Ala Gln Lys 
                405                 


