                         SEQUENCE LISTING

<110>  Blood Center of Wisconsin
       Malarkannan, Subramaniam M
 
<120>  A METHOD OF PROVIDING CELLULAR THERAPY USING MODIFIED NATURAL 
       KILLER CELLS OR T LYMPHOCYTES

<130>  160180.00092

<150>  US 61/866,348
<151>  2013-08-15

<150>  US 61/708,837
<151>  2012-10-02

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg Val Thr Gly Pro Asn Ser Ser Ser Gly Ile 
            20                  25                  30          


Gln Ala Arg Lys Asn Leu Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Asn Val Pro Lys Phe Gly Ser Pro Lys Pro Pro Val 
    50                  55                  60                  


Ala Val Lys Pro Ser Ser Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala 
                85                  90                  95      


Ser Leu Thr Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Gly Pro Lys Pro Ile Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr 
        115                 120                 125             


Phe Pro Trp Pro Pro Gly Asn Lys Pro Ser Leu His Ser Val Asn Gln 
    130                 135                 140                 


Asp His Asp Leu Lys Pro Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro 
145                 150                 155                 160 


Thr Ser Glu Asn Glu Gln Lys Gln Ala Phe Pro Lys Leu Thr Gly Val 
                165                 170                 175     


Lys Gly Lys Phe Met Ser Ala Ser Gln Asp Leu Glu Pro Lys Pro Leu 
            180                 185                 190         


Phe Pro Lys Pro Ala Phe Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn 
        195                 200                 205             


Ser His Glu Asp Glu Ser Pro Met Lys Asn Val Ser Ser Ser Lys Gly 
    210                 215                 220                 


Ser Pro Ala Pro Leu Gly Val Arg Ser Lys Ser Gly Pro Leu Lys Pro 
225                 230                 235                 240 


Ala Arg Glu Asp Ser Glu Asn Lys Asp His Ala Gly Glu Ile Ser Ser 
                245                 250                 255     


Leu Pro Phe Pro Gly Val Val Leu Lys Pro Ala Ala Ser Arg Gly Gly 
            260                 265                 270         


Pro Gly Leu Ser Lys Asn Gly Glu Glu Lys Lys Glu Asp Arg Lys Ile 
        275                 280                 285             


Asp Ala Ala Lys Asn Thr Phe Gln Ser Lys Ile Asn Gln Glu Glu Leu 
    290                 295                 300                 


Ala Ser Gly Thr Pro Pro Ala Arg Phe Pro Lys Ala Pro Ser Lys Leu 
305                 310                 315                 320 


Thr Val Gly Gly Pro Trp Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp 
                325                 330                 335     


Lys Asn Ser Ala Thr Pro Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr 
            340                 345                 350         


Leu Gly Pro Pro Pro Pro Lys Pro Asn Arg Pro Pro Asn Val Asp Leu 
        355                 360                 365             


Thr Lys Phe His Lys Thr Ser Ser Gly Asn Ser Thr Ser Lys Gly Gln 
    370                 375                 380                 


Thr Ser Tyr Ser Thr Thr Ser Leu Pro Pro Pro Pro Pro Ser His Pro 
385                 390                 395                 400 


Ala Ser Gln Pro Pro Leu Pro Ala Ser His Pro Ser Gln Pro Pro Val 
                405                 410                 415     


Pro Ser Leu Pro Pro Arg Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser 
            420                 425                 430         


Pro Val Asn Glu Asp Asn Gln Asp Gly Val Thr His Ser Asp Gly Ala 
        435                 440                 445             


Gly Asn Leu Asp Glu Glu Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp 
    450                 455                 460                 


Ile Glu Ala Ser Lys Glu Arg Glu Lys Lys Arg Glu Lys Glu Glu Lys 
465                 470                 475                 480 


Lys Arg Leu Glu Leu Glu Lys Lys Glu Gln Lys Glu Lys Glu Lys Lys 
                485                 490                 495     


Glu Gln Glu Ile Lys Lys Lys Phe Lys Leu Thr Gly Pro Ile Gln Val 
            500                 505                 510         


Ile His Leu Ala Lys Ala Cys Cys Asp Val Lys Gly Gly Lys Asn Glu 
        515                 520                 525             


Leu Ser Phe Lys Gln Gly Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp 
    530                 535                 540                 


Asn Pro Glu Gly Lys Trp Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly 
545                 550                 555                 560 


Tyr Ile Lys Thr Thr Ala Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu 
                565                 570                 575     


Lys Lys Asp Ser Leu Gly Ala Pro Ser Arg Pro Ile Glu Asp Asp Gln 
            580                 585                 590         


Glu Val Tyr Asp Asp Val Ala Glu Gln Asp Asp Ile Ser Ser His Ser 
        595                 600                 605             


Gln Ser Gly Ser Gly Gly Ile Phe Pro Pro Pro Pro Asp Asp Asp Ile 
    610                 615                 620                 


Tyr Asp Gly Ile Glu Glu Glu Asp Ala Asp Asp Gly Phe Pro Ala Pro 
625                 630                 635                 640 


Pro Lys Gln Leu Asp Met Gly Asp Glu Val Tyr Asp Asp Val Asp Thr 
                645                 650                 655     


Ser Asp Phe Pro Val Ser Ser Ala Glu Met Ser Gln Gly Thr Asn Val 
            660                 665                 670         


Gly Lys Ala Lys Thr Glu Glu Lys Asp Leu Lys Lys Leu Lys Lys Gln 
        675                 680                 685             


Glu Lys Glu Glu Lys Asp Phe Arg Lys Lys Phe Lys Tyr Asp Gly Glu 
    690                 695                 700                 


Ile Arg Val Leu Tyr Ser Thr Lys Val Thr Thr Ser Ile Thr Ser Lys 
705                 710                 715                 720 


Lys Trp Gly Thr Arg Asp Leu Gln Val Lys Pro Gly Glu Ser Leu Glu 
                725                 730                 735     


Val Ile Gln Thr Thr Asp Asp Thr Lys Val Leu Cys Arg Asn Glu Glu 
            740                 745                 750         


Gly Lys Tyr Gly Tyr Val Leu Arg Ser Tyr Leu Ala Asp Asn Asp Gly 
        755                 760                 765             


Glu Ile Tyr Asp Asp Ile Ala Asp Gly Cys Ile Tyr Asp Asn Asp 
    770                 775                 780             


<210>  2
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Arg Ala Ala Gly Leu Cys Cys 
225                 230                 235                 240 


Arg Leu Val Val Pro Cys His Lys Gly Met Pro Arg Leu Thr Asp Leu 
                245                 250                 255     


Ser Val Lys Thr Lys Asp Val Trp Glu Ile Pro Arg Glu Ser Leu Gln 
            260                 265                 270         


Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp Met Gly 
        275                 280                 285             


Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
    290                 295                 300                 


Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys 
305                 310                 315                 320 


Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu 
                325                 330                 335     


Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp 
            340                 345                 350         


Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val 
        355                 360                 365             


Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met 
    370                 375                 380                 


Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn 
385                 390                 395                 400 


Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
                405                 410                 415     


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg 
    450                 455                 460                 


Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu 
465                 470                 475                 480 


Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His 
                485                 490                 495     


Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr 
            500                 505                 510         


Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
        515                 520                 525             


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535         


<210>  3
<211>  819
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Lys Phe Asn Thr Gly Ser Asn Pro Thr Glu Glu Ala Ala Thr 
1               5                   10                  15      


Ser Ser Arg Pro Phe Lys Val Ala Gly Gln Ser Ser Pro Ser Gly Ile 
            20                  25                  30          


Gln Ser Arg Lys Asn Leu Phe Asp Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Ser Met Pro Lys Phe Gly Thr Thr Lys Pro Pro Leu 
    50                  55                  60                  


Ala Ala Lys Pro Thr Tyr Glu Glu Lys Pro Glu Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Gly Ser Pro Arg Phe Gly Thr Gln Pro 
                85                  90                  95      


Asn Ser Val Ser Arg Asp Pro Glu Val Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Ser Pro Lys Pro Thr Ser Leu Thr Lys Glu Asp Ser Lys Pro Val 
        115                 120                 125             


Val Leu Arg Pro Pro Gly Asn Lys Leu His Asn Leu Asn Gln Glu Ser 
    130                 135                 140                 


Asp Leu Lys Thr Pro Gly Pro Lys Pro Gly Pro Ala Pro Pro Val Pro 
145                 150                 155                 160 


Glu Asn Glu Leu Lys Pro Gly Phe Ser Lys Val Ala Gly Ala Lys Ser 
                165                 170                 175     


Lys Phe Met Pro Ala Ala Gln Asp Thr Asp Ser Lys Pro Arg Phe Pro 
            180                 185                 190         


Arg His Thr Phe Gly Gln Lys Pro Ser Leu Ser Thr Glu Asp Ser Gln 
        195                 200                 205             


Glu Glu Asn Thr Ser Lys Asn Val Pro Val Gln Lys Gly Ser Pro Val 
    210                 215                 220                 


Gln Leu Gly Ala Lys Ser Lys Gly Ala Pro Phe Lys Pro Pro Lys Glu 
225                 230                 235                 240 


Asp Pro Glu Asp Lys Asp His Gly Ala Pro Ser Ser Pro Phe Pro Gly 
                245                 250                 255     


Val Val Leu Lys Pro Ala Ala Ser Arg Gly Ser Pro Gly Leu Ser Lys 
            260                 265                 270         


Asn Phe Glu Glu Lys Lys Glu Asp Arg Lys Thr Asp Leu Ala Lys Asn 
        275                 280                 285             


Ile Phe Leu Asn Lys Leu Asn Gln Glu Glu Pro Ala Arg Phe Pro Lys 
    290                 295                 300                 


Ala Pro Ser Lys Leu Thr Ala Gly Thr Pro Trp Gly Gln Ser Gln Glu 
305                 310                 315                 320 


Lys Glu Gly Asp Lys Asn Ser Ala Thr Pro Lys Gln Lys Ala Leu Pro 
                325                 330                 335     


Pro Leu Ser Val Leu Gly Pro Pro Pro Pro Lys Pro Asn Arg Pro Pro 
            340                 345                 350         


Asn Val Asp Leu Thr Arg Phe Arg Lys Ala Asp Ser Ala Asn Ser Ala 
        355                 360                 365             


Thr Lys Ser Gln Thr Pro Tyr Ser Thr Thr Ser Leu Pro Pro Pro Pro 
    370                 375                 380                 


Pro Thr His Pro Ala Ser Gln Pro Pro Leu Pro Ala Ser His Pro Ala 
385                 390                 395                 400 


His Pro Pro Val Pro Ser Leu Pro Pro Arg Asn Ile Lys Pro Pro Leu 
                405                 410                 415     


Asp Leu Lys His Pro Ile Asn Asp Glu Asn Gln Asp Gly Val Met His 
            420                 425                 430         


Ser Asp Gly Thr Gly Asn Leu Glu Glu Glu Gln Glu Ser Glu Gly Glu 
        435                 440                 445             


Thr Tyr Glu Asp Ile Asp Ser Ser Lys Glu Arg Asp Lys Lys Arg Glu 
    450                 455                 460                 


Lys Glu Glu Lys Lys Arg Leu Glu Leu Glu Arg Lys Glu Gln Lys Glu 
465                 470                 475                 480 


Arg Glu Lys Lys Glu Gln Glu Leu Lys Lys Lys Phe Lys Leu Thr Gly 
                485                 490                 495     


Pro Ile Gln Val Ile His His Ala Lys Ala Cys Cys Asp Val Lys Gly 
            500                 505                 510         


Gly Lys Asn Glu Leu Ser Phe Lys Gln Gly Glu Asp Ile Glu Ile Ile 
        515                 520                 525             


Arg Ile Thr Asp Asn Pro Glu Gly Lys Trp Leu Gly Arg Thr Ala Arg 
    530                 535                 540                 


Gly Ser Tyr Gly Tyr Ile Lys Thr Thr Ala Val Glu Ile Asp Tyr Asp 
545                 550                 555                 560 


Ser Leu Lys Arg Lys Lys Asn Ser Leu Asn Ala Val Pro Pro Arg Leu 
                565                 570                 575     


Val Glu Asp Asp Gln Asp Val Tyr Asp Asp Val Ala Glu Gln Asp Ala 
            580                 585                 590         


Pro Asn Ser His Gly Gln Ser Gly Ser Gly Gly Met Phe Pro Pro Pro 
        595                 600                 605             


Pro Thr Asp Asp Glu Ile Tyr Asp Gly Ile Glu Glu Glu Asp Asp Asp 
    610                 615                 620                 


Asp Gly Ser Val Pro Gln Val Asp Glu Lys Thr Asn Ala Trp Ser Trp 
625                 630                 635                 640 


Gly Ile Leu Lys Met Leu Lys Gly Lys Asp Asp Arg Lys Lys Ser Ile 
                645                 650                 655     


Arg Glu Lys Pro Lys Val Ser Glu Ser Asp Asn Asn Glu Gly Ser Ser 
            660                 665                 670         


Leu Pro Ser Gln His Lys Gln Leu Asp Val Gly Glu Glu Val Tyr Asp 
        675                 680                 685             


Asp Val Asp Ala Ser Asp Phe Pro Pro Pro Pro Ala Glu Met Ser Gln 
    690                 695                 700                 


Gly Met Ser Val Gly Arg Ala Lys Thr Glu Glu Lys Asp Pro Lys Lys 
705                 710                 715                 720 


Leu Lys Lys Gln Glu Lys Glu Glu Lys Asp Leu Arg Lys Lys Phe Lys 
                725                 730                 735     


Tyr Asp Gly Glu Ile Arg Val Leu Tyr Ser Thr Lys Val Ala Ser Ser 
            740                 745                 750         


Leu Thr Ser Lys Lys Trp Gly Ala Arg Asp Leu Gln Ile Lys Pro Gly 
        755                 760                 765             


Glu Ser Leu Glu Val Ile Gln Ser Thr Asp Asp Thr Lys Val Leu Cys 
    770                 775                 780                 


Arg Asn Glu Glu Gly Lys Tyr Gly Tyr Val Leu Arg Ser Tyr Leu Val 
785                 790                 795                 800 


Asp Asn Asp Gly Glu Ile Tyr Asp Asp Ile Ala Asp Gly Cys Ile Tyr 
                805                 810                 815     


Asp Asn Asp 
            


