                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Carson, Dennis A.
       Cottam, Howard B.
       Hayashi, Tomoko
       Chan, Michael
       Corr, Mary  P.
 
<120>  Compositions and Methods for Modulating TLR4

<130>  88654-008910PC-877022

<150>  US 61/706,294
<151>  2012-09-27

<150>  US 61/824,540
<151>  2013-05-17

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  835
<212>  PRT
<213>  Mus musculus

<400>  1

Met Met Pro Pro Trp Leu Leu Ala Arg Thr Leu Ile Met Ala Leu Phe 
1               5                   10                  15      


Phe Ser Cys Leu Thr Pro Gly Ser Leu Asn Pro Cys Ile Glu Val Val 
            20                  25                  30          


Pro Asn Ile Thr Tyr Gln Cys Met Asp Gln Lys Leu Ser Lys Val Pro 
        35                  40                  45              


Asp Asp Ile Pro Ser Ser Thr Lys Asn Ile Asp Leu Ser Phe Asn Pro 
    50                  55                  60                  


Leu Lys Ile Leu Lys Ser Tyr Ser Phe Ser Asn Phe Ser Glu Leu Gln 
65                  70                  75                  80  


Trp Leu Asp Leu Ser Arg Cys Glu Ile Glu Thr Ile Glu Asp Lys Ala 
                85                  90                  95      


Trp His Gly Leu His His Leu Ser Asn Leu Ile Leu Thr Gly Asn Pro 
            100                 105                 110         


Ile Gln Ser Phe Ser Pro Gly Ser Phe Ser Gly Leu Thr Ser Leu Glu 
        115                 120                 125             


Asn Leu Val Ala Val Glu Thr Lys Leu Ala Ser Leu Glu Ser Phe Pro 
    130                 135                 140                 


Ile Gly Gln Leu Ile Thr Leu Lys Lys Leu Asn Val Ala His Asn Phe 
145                 150                 155                 160 


Ile His Ser Cys Lys Leu Pro Ala Tyr Phe Ser Asn Leu Thr Asn Leu 
                165                 170                 175     


Val His Val Asp Leu Ser Tyr Asn Tyr Ile Gln Thr Ile Thr Val Asn 
            180                 185                 190         


Asp Leu Gln Phe Leu Arg Glu Asn Pro Gln Val Asn Leu Ser Leu Asp 
        195                 200                 205             


Met Ser Leu Asn Pro Ile Asp Phe Ile Gln Asp Gln Ala Phe Gln Gly 
    210                 215                 220                 


Ile Lys Leu His Glu Leu Thr Leu Arg Gly Asn Phe Asn Ser Ser Asn 
225                 230                 235                 240 


Ile Met Lys Thr Cys Leu Gln Asn Leu Ala Gly Leu His Val His Arg 
                245                 250                 255     


Leu Ile Leu Gly Glu Phe Lys Asp Glu Arg Asn Leu Glu Ile Phe Glu 
            260                 265                 270         


Pro Ser Ile Met Glu Gly Leu Cys Asp Val Thr Ile Asp Glu Phe Arg 
        275                 280                 285             


Leu Thr Tyr Thr Asn Asp Phe Ser Asp Asp Ile Val Lys Phe His Cys 
    290                 295                 300                 


Leu Ala Asn Val Ser Ala Met Ser Leu Ala Gly Val Ser Ile Lys Tyr 
305                 310                 315                 320 


Leu Glu Asp Val Pro Lys His Phe Lys Trp Gln Ser Leu Ser Ile Ile 
                325                 330                 335     


Arg Cys Gln Leu Lys Gln Phe Pro Thr Leu Asp Leu Pro Phe Leu Lys 
            340                 345                 350         


Ser Leu Thr Leu Thr Met Asn Lys Gly Ser Ile Ser Phe Lys Lys Val 
        355                 360                 365             


Ala Leu Pro Ser Leu Ser Tyr Leu Asp Leu Ser Arg Asn Ala Leu Ser 
    370                 375                 380                 


Phe Ser Gly Cys Cys Ser Tyr Ser Asp Leu Gly Thr Asn Ser Leu Arg 
385                 390                 395                 400 


His Leu Asp Leu Ser Phe Asn Gly Ala Ile Ile Met Ser Ala Asn Phe 
                405                 410                 415     


Met Gly Leu Glu Glu Leu Gln His Leu Asp Phe Gln His Ser Thr Leu 
            420                 425                 430         


Lys Arg Val Thr Glu Phe Ser Ala Phe Leu Ser Leu Glu Lys Leu Leu 
        435                 440                 445             


Tyr Leu Asp Ile Ser Tyr Thr Asn Thr Lys Ile Asp Phe Asp Gly Ile 
    450                 455                 460                 


Phe Leu Gly Leu Thr Ser Leu Asn Thr Leu Lys Met Ala Gly Asn Ser 
465                 470                 475                 480 


Phe Lys Asp Asn Thr Leu Ser Asn Val Phe Ala Asn Thr Thr Asn Leu 
                485                 490                 495     


Thr Phe Leu Asp Leu Ser Lys Cys Gln Leu Glu Gln Ile Ser Trp Gly 
            500                 505                 510         


Val Phe Asp Thr Leu His Arg Leu Gln Leu Leu Asn Met Ser His Asn 
        515                 520                 525             


Asn Leu Leu Phe Leu Asp Ser Ser His Tyr Asn Gln Leu Tyr Ser Leu 
    530                 535                 540                 


Ser Thr Leu Asp Cys Ser Phe Asn Arg Ile Glu Thr Ser Lys Gly Ile 
545                 550                 555                 560 


Leu Gln His Phe Pro Lys Ser Leu Ala Phe Phe Asn Leu Thr Asn Asn 
                565                 570                 575     


Ser Val Ala Cys Ile Cys Glu His Gln Lys Phe Leu Gln Trp Val Lys 
            580                 585                 590         


Glu Gln Lys Gln Phe Leu Val Asn Val Glu Gln Met Thr Cys Ala Thr 
        595                 600                 605             


Pro Val Glu Met Asn Thr Ser Leu Val Leu Asp Phe Asn Asn Ser Thr 
    610                 615                 620                 


Cys Tyr Met Tyr Lys Thr Ile Ile Ser Val Ser Val Val Ser Val Ile 
625                 630                 635                 640 


Val Val Ser Thr Val Ala Phe Leu Ile Tyr His Phe Tyr Phe His Leu 
                645                 650                 655     


Ile Leu Ile Ala Gly Cys Lys Lys Tyr Ser Arg Gly Glu Ser Ile Tyr 
            660                 665                 670         


Asp Ala Phe Val Ile Tyr Ser Ser Gln Asn Glu Asp Trp Val Arg Asn 
        675                 680                 685             


Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Arg Phe His Leu Cys 
    690                 695                 700                 


Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile 
705                 710                 715                 720 


Ile Gln Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val Val Ser 
                725                 730                 735     


Arg His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala 
            740                 745                 750         


Gln Thr Trp Gln Phe Leu Ser Ser Arg Ser Gly Ile Ile Phe Ile Val 
        755                 760                 765             


Leu Glu Lys Val Glu Lys Ser Leu Leu Arg Gln Gln Val Glu Leu Tyr 
    770                 775                 780                 


Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Asn Pro Leu 
785                 790                 795                 800 


Gly Arg His Ile Phe Trp Arg Arg Leu Lys Asn Ala Leu Leu Asp Gly 
                805                 810                 815     


Lys Ala Ser Asn Pro Glu Gln Thr Ala Glu Glu Glu Gln Glu Thr Ala 
            820                 825                 830         


Thr Trp Thr 
        835 


<210>  2
<211>  160
<212>  PRT
<213>  Mus musculus

<400>  2

Met Leu Pro Phe Ile Leu Phe Ser Thr Leu Leu Ser Pro Ile Leu Thr 
1               5                   10                  15      


Glu Ser Glu Lys Gln Gln Trp Phe Cys Asn Ser Ser Asp Ala Ile Ile 
            20                  25                  30          


Ser Tyr Ser Tyr Cys Asp His Leu Lys Phe Pro Ile Ser Ile Ser Ser 
        35                  40                  45              


Glu Pro Cys Ile Arg Leu Arg Gly Thr Asn Gly Phe Val His Val Glu 
    50                  55                  60                  


Phe Ile Pro Arg Gly Asn Leu Lys Tyr Leu Tyr Phe Asn Leu Phe Ile 
65                  70                  75                  80  


Ser Val Asn Ser Ile Glu Leu Pro Lys Arg Lys Glu Val Leu Cys His 
                85                  90                  95      


Gly His Asp Asp Asp Tyr Ser Phe Cys Arg Ala Leu Lys Gly Glu Thr 
            100                 105                 110         


Val Asn Thr Ser Ile Pro Phe Ser Phe Glu Gly Ile Leu Phe Pro Lys 
        115                 120                 125             


Gly His Tyr Arg Cys Val Ala Glu Ala Ile Ala Gly Asp Thr Glu Glu 
    130                 135                 140                 


Lys Leu Phe Cys Leu Asn Phe Thr Ile Ile His Arg Arg Asp Val Asn 
145                 150                 155                 160 


