                         SEQUENCE LISTING

<110>  University of Washington Center for Commercialization
       Lieber, Andre
       Wang, Hongjie
 
<120>  Desmoglein 2 (DSG2) Binding Proteins and Uses Therefor

<130>  13-1205-PCT

<150>  61/705523
<151>  2012-09-25

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  195
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is V or P

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is N or K

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is T or absent

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is E or R

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is Q or I

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is M or I

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is M or E

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is Y, A, N or D

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is S or G

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is S or K

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is S or N

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is P or N

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is C or S

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is T or I

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is N or T

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X is T or N

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is F or Y

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X is Y or T

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is V or L

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  X is I or M

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  X is V or A

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is N or D

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  X is N, Y or D

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  X is F or V

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  X is M or T

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  X is F or T

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X is K or T

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  X is Y, H or N

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  X is R or K

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  X is F or I

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  X is T or N

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  X is F or Y

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  X is S or A

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is N or H

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X is T or P

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is S, R or D

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  X is S or L

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is P or D

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  X is N or E

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  X is H, L or P

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  X is K or E

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  X is S or Y

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  X is G or K

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  X is N or T

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  X is M or absent

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X is A or absent

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  X is T or absent

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  X is G or absent

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  X is I, L or D

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  X is T, F, S, or L

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  X is S or G

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  X is V, D or absent

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  X is L or absent

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  X is N or P

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  X is N, D or V

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  X is N or A

<220>
<221>  MISC_FEATURE
<222>  (118)..(118)
<223>  X is S or G

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X is R or T

<220>
<221>  MISC_FEATURE
<222>  (120)..(120)
<223>  X is E or H

<220>
<221>  MISC_FEATURE
<222>  (121)..(121)
<223>  X is N, K or absent

<220>
<221>  MISC_FEATURE
<222>  (122)..(122)
<223>  X is E, G or absent

<220>
<221>  MISC_FEATURE
<222>  (124)..(124)
<223>  X is Y or F

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  X is Y or F

<220>
<221>  MISC_FEATURE
<222>  (128)..(128)
<223>  X is T or Q

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  X is H or Y

<220>
<221>  MISC_FEATURE
<222>  (132)..(132)
<223>  X is T, K or E

<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  X is H, G or R

<220>
<221>  MISC_FEATURE
<222>  (137)..(137)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (138)..(138)
<223>  X is L or A

<220>
<221>  MISC_FEATURE
<222>  (141)..(141)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (142)..(142)
<223>  X is D or E

<220>
<221>  MISC_FEATURE
<222>  (143)..(143)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (144)..(144)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (149)..(149)
<223>  X is Q, R or K

<220>
<221>  MISC_FEATURE
<222>  (151)..(151)
<223>  X is A or L

<220>
<221>  MISC_FEATURE
<222>  (152)..(152)
<223>  X is I, P or L

<220>
<221>  MISC_FEATURE
<222>  (153)..(153)
<223>  X is R, N or D

<220>
<221>  MISC_FEATURE
<222>  (154)..(154)
<223>  X is A, N, S or D

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  X is E, R or D

<220>
<221>  MISC_FEATURE
<222>  (159)..(159)
<223>  X is C or V

<220>
<221>  MISC_FEATURE
<222>  (160)..(160)
<223>  X is I or M

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  X is R or T

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  X is I, V or F

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  X is T or L

<220>
<221>  MISC_FEATURE
<222>  (166)..(166)
<223>  X is W or L

<220>
<221>  MISC_FEATURE
<222>  (167)..(167)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (170)..(170)
<223>  X is D, L, or V

<220>
<221>  MISC_FEATURE
<222>  (174)..(174)
<223>  X is G, V or absent

<220>
<221>  MISC_FEATURE
<222>  (175)..(175)
<223>  X is Q or absent

<220>
<221>  MISC_FEATURE
<222>  (177)..(177)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (178)..(178)
<223>  X is A or Q

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  X is A or T

<220>
<221>  MISC_FEATURE
<222>  (182)..(182)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (189)..(189)
<223>  X is Y or S

<400>  1

Thr Leu Trp Thr Gly Xaa Xaa Pro Xaa Xaa Ala Asn Cys Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa Lys Leu Xaa Leu Xaa Leu Val Lys 
            20                  25                  30          


Xaa Gly Xaa Xaa Val Xaa Xaa Xaa Val Xaa Xaa Xaa Gly Xaa Ser Xaa 
        35                  40                  45              


Xaa Xaa Asn Xaa Leu Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Xaa Xaa Glu 
    50                  55                  60                  


Leu Xaa Phe Asp Xaa Xaa Gly Xaa Xaa Leu Xaa Xaa Xaa Ser Ser Leu 
65                  70                  75                  80  


Lys Thr Xaa Leu Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa Ala 
                85                  90                  95      


Xaa Xaa Xaa Ala Xaa Xaa Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa Ile Xaa Gly Xaa 
        115                 120                 125             


Cys Xaa Tyr Xaa Ala Ser Asp Xaa Xaa Xaa Phe Pro Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Val Met Leu Asn Xaa Arg Xaa Xaa Xaa Xaa Xaa Thr Ser Tyr Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Trp Ser Xaa Xaa Xaa Gly Xaa Ala Pro Glu Xaa Xaa Thr 
                165                 170                 175     


Xaa Xaa Xaa Thr Leu Xaa Thr Ser Pro Phe Thr Phe Xaa Tyr Ile Arg 
            180                 185                 190         


Glu Asp Asp 
        195 


<210>  2
<211>  188
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is V or P

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Nor K

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is E or R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is Q or I

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is M or I

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is M or E

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is Y, A, N or D

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is S or G

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is S or K

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is S or N

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is P or N

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is C or S

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is N or T

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  X is T or N

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  X is F or Y

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X is T or Y

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X is V or L

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is I or M

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  X is V or A

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  X is N or D

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is N, Y or D

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  X is F or V

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X is M or T

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  X is F or T

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  X is K or T

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X is Y, H or N

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  X is R or K

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  X is F or I

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  X is T or N

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  X is F or Y

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  X is S or A

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  X is N or H

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X is T or P

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X is S, R or D

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is L or S

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  X is P or D

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  X is N or E

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  X is H, L or P

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  X is K or E

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  X is S or Y

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  X is G or K

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  X is N or T

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  X is I, L or D

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X is T, F, S, or L

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  X is S or G

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  X is V, D or absent

<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  X is L or absent

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  X is N or P

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  X is N, D or V

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  X is N or A

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  X is S or G

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  X is R or T

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  X is E or H

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  X is N, K or absent

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  X is E, G or absent

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X is Y or F

<220>
<221>  MISC_FEATURE
<222>  (121)..(121)
<223>  X is Y or F

<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  X is T or Q

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  X is H or Y

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  X is T, K or E

<220>
<221>  MISC_FEATURE
<222>  (131)..(131)
<223>  X is H, G or R

<220>
<221>  MISC_FEATURE
<222>  (132)..(132)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  X is L or A

<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (137)..(137)
<223>  X is D or E

<220>
<221>  MISC_FEATURE
<222>  (138)..(138)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (139)..(139)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (144)..(144)
<223>  X is Q, R or K

<220>
<221>  MISC_FEATURE
<222>  (146)..(146)
<223>  X is A or L

<220>
<221>  MISC_FEATURE
<222>  (147)..(147)
<223>  X is I, P or L

<220>
<221>  MISC_FEATURE
<222>  (148)..(148)
<223>  X is R, N or D

<220>
<221>  MISC_FEATURE
<222>  (149)..(149)
<223>  X is A, S, N or D

<220>
<221>  MISC_FEATURE
<222>  (150)..(150)
<223>  X is D, E, or R

<220>
<221>  MISC_FEATURE
<222>  (154)..(154)
<223>  X is C or V

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  X is I or M

<220>
<221>  MISC_FEATURE
<222>  (156)..(156)
<223>  X is R or T

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  X is I, V or F

<220>
<221>  MISC_FEATURE
<222>  (158)..(158)
<223>  X is T or L

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  X is W or L

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  X is D, L or V

<220>
<221>  MISC_FEATURE
<222>  (170)..(170)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (171)..(171)
<223>  X is A or Q

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  X is A or T

<220>
<221>  MISC_FEATURE
<222>  (175)..(175)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (182)..(182)
<223>  X is Y or S

<400>  2

Thr Leu Trp Thr Gly Xaa Xaa Pro Xaa Ala Asn Cys Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Asp Xaa Lys Leu Xaa Leu Xaa Leu Val Lys Xaa 
            20                  25                  30          


Gly Xaa Xaa Val Xaa Xaa Xaa Val Xaa Xaa Xaa Gly Xaa Ser Xaa Xaa 
        35                  40                  45              


Xaa Asn Xaa Leu Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Xaa Xaa Glu Leu 
    50                  55                  60                  


Xaa Phe Asp Xaa Xaa Gly Xaa Xaa Leu Xaa Xaa Xaa Ser Ser Leu Lys 
65                  70                  75                  80  


Thr Xaa Leu Xaa Xaa Xaa Xaa Xaa Gln Xaa Ala Xaa Xaa Xaa Ala Xaa 
                85                  90                  95      


Xaa Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Asn Xaa Ile Xaa Gly Xaa Cys Xaa Tyr Xaa Ala 
        115                 120                 125             


Ser Asp Xaa Xaa Xaa Phe Pro Xaa Xaa Xaa Xaa Val Met Leu Asn Xaa 
    130                 135                 140                 


Arg Xaa Xaa Xaa Xaa Xaa Thr Ser Tyr Xaa Xaa Xaa Xaa Xaa Trp Ser 
145                 150                 155                 160 


Xaa Xaa Xaa Gly Xaa Ala Pro Glu Thr Xaa Xaa Xaa Thr Leu Xaa Thr 
                165                 170                 175     


Ser Pro Phe Thr Phe Xaa Tyr Ile Arg Glu Asp Asp 
            180                 185             


<210>  3
<211>  188
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is V or P

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is N or K

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is E or R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is Q or I

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is M or I

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is M or E

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is Y, A, N or D

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is S or G

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is S or K

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is S or N

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is P or N

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is C or S

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is N or T

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  X is T or N

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  X is F or Y

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X is T or Y

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X is V or L

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is I or M

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  X is V or A

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  X is N or D

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is N, Y or D

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  X is F or V

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X is M or T

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  X is F or T

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  X is K or T

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X is Y, H or N

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  X is R or K

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  X is F or I

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  X is T or N

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  X is F or Y

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  X is A or S

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  X is A or T

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  X is N or H

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X is T or P

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X is S, R or D

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is L or S

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  X is P or D

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  X is N or E

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  X is H, L or P

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  X is K or E

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  X is S or Y

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  X is G or K

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  X is N or T

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  X is I, L or D

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X is T, F, S, or L

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  X is S or G

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  X is V, D or absent

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  X is N or P

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  X is N, D or V

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  X is N or A

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  X is S or G

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  X is R or T

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  X is E or H

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  X is N, K or absent

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  X is E, G or absent

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X is Y or F

<220>
<221>  MISC_FEATURE
<222>  (121)..(121)
<223>  X is Y or F

<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  X is T or Q

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  X is Y or H

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  X is T, K or E

<220>
<221>  MISC_FEATURE
<222>  (131)..(131)
<223>  X is H, G or R

<220>
<221>  MISC_FEATURE
<222>  (132)..(132)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  X is L or A

<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (137)..(137)
<223>  X is D or E

<220>
<221>  MISC_FEATURE
<222>  (138)..(138)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (139)..(139)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (144)..(144)
<223>  X is Q, R, or K

<220>
<221>  MISC_FEATURE
<222>  (146)..(146)
<223>  X is A or L

<220>
<221>  MISC_FEATURE
<222>  (147)..(147)
<223>  X is I, P or L

<220>
<221>  MISC_FEATURE
<222>  (148)..(148)
<223>  X is R, N or D

<220>
<221>  MISC_FEATURE
<222>  (149)..(149)
<223>  X is A, S, N or D

<220>
<221>  MISC_FEATURE
<222>  (150)..(150)
<223>  X is E, R or D

<220>
<221>  MISC_FEATURE
<222>  (154)..(154)
<223>  X is C or V

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  X is I or M

<220>
<221>  MISC_FEATURE
<222>  (156)..(156)
<223>  X is R or T

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  X is I, V or F

<220>
<221>  MISC_FEATURE
<222>  (158)..(158)
<223>  X is T or L

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  X is W or L

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  X is D, L or V

<220>
<221>  MISC_FEATURE
<222>  (170)..(170)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (171)..(171)
<223>  X is A or Q

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  X is A or T

<220>
<221>  MISC_FEATURE
<222>  (175)..(175)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (182)..(182)
<223>  X is Y or S

<400>  3

Thr Leu Trp Thr Gly Xaa Xaa Pro Xaa Ala Asn Cys Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Asp Xaa Lys Leu Xaa Leu Xaa Leu Val Lys Xaa 
            20                  25                  30          


Gly Xaa Xaa Val Xaa Xaa Xaa Val Xaa Xaa Xaa Gly Xaa Ser Xaa Xaa 
        35                  40                  45              


Xaa Asn Xaa Leu Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Xaa Xaa Glu Leu 
    50                  55                  60                  


Xaa Phe Asp Xaa Xaa Gly Xaa Xaa Leu Xaa Xaa Xaa Ser Ser Leu Lys 
65                  70                  75                  80  


Thr Xaa Leu Xaa Xaa Xaa Xaa Xaa Gln Xaa Ala Xaa Xaa Xaa Ala Xaa 
                85                  90                  95      


Xaa Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe Xaa Leu Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Asn Xaa Ile Xaa Gly Xaa Cys Xaa Tyr Xaa Ala 
        115                 120                 125             


Ser Asp Xaa Xaa Xaa Phe Pro Xaa Xaa Xaa Xaa Val Met Leu Asn Xaa 
    130                 135                 140                 


Arg Xaa Xaa Xaa Xaa Xaa Thr Ser Tyr Xaa Xaa Xaa Xaa Xaa Trp Ser 
145                 150                 155                 160 


Xaa Xaa Xaa Gly Xaa Ala Pro Glu Thr Xaa Xaa Xaa Thr Leu Xaa Thr 
                165                 170                 175     


Ser Pro Phe Thr Phe Xaa Tyr Ile Arg Glu Asp Asp 
            180                 185             


<210>  4
<211>  188
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  X is I or L

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  X is H, L or P

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  X is K or E

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X is T, F, S, or L

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  X is V, D or absent

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  X is E, G or absent

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X is Y or F

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  X is T, K or E

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  X is N or S

<400>  4

Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn Cys Ile Ile Glu Tyr 
1               5                   10                  15      


Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu Ile Leu Val Lys Asn 
            20                  25                  30          


Gly Gly Xaa Val Asn Gly Tyr Val Thr Leu Met Gly Ala Ser Asp Tyr 
        35                  40                  45              


Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser Ile Asn Val Glu Leu 
    50                  55                  60                  


Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp Ser Ser Ser Leu Lys 
65                  70                  75                  80  


Thr Asp Leu Glu Xaa Xaa Tyr Lys Gln Thr Ala Asp Xaa Ser Ala Arg 
                85                  90                  95      


Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe Xaa Leu Pro Asn Ala 
            100                 105                 110         


Gly Thr His Asn Xaa Asn Xaa Ile Phe Gly Gln Cys Tyr Tyr Xaa Ala 
        115                 120                 125             


Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr Val Met Leu Asn Lys 
    130                 135                 140                 


Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met Thr Phe Leu Trp Ser 
145                 150                 155                 160 


Leu Xaa Ala Gly Leu Ala Pro Glu Thr Thr Gln Ala Thr Leu Ile Thr 
                165                 170                 175     


Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp Asp 
            180                 185             


<210>  5
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  5

Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn Cys Ile Ile Glu Tyr 
1               5                   10                  15      


Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu Ile Leu Val Lys Asn 
            20                  25                  30          


Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met Gly Ala Ser Asp Tyr 
        35                  40                  45              


Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser Ile Asn Val Glu Leu 
    50                  55                  60                  


Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp Ser Ser Ser Leu Lys 
65                  70                  75                  80  


Thr Asp Leu Glu Leu Lys Tyr Lys Gln Thr Ala Asp Phe Ser Ala Arg 
                85                  90                  95      


Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe Val Leu Pro Asn Ala 
            100                 105                 110         


Gly Thr His Asn Glu Asn Phe Ile Phe Gly Gln Cys Tyr Tyr Lys Ala 
        115                 120                 125             


Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr Val Met Leu Asn Lys 
    130                 135                 140                 


Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met Thr Phe Leu Trp Ser 
145                 150                 155                 160 


Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln Ala Thr Leu Ile Thr 
                165                 170                 175     


Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp Asp 
            180                 185             


<210>  6
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  6

Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn Cys Ile Ile Glu Tyr 
1               5                   10                  15      


Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu Ile Leu Val Lys Asn 
            20                  25                  30          


Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met Gly Ala Ser Asp Tyr 
        35                  40                  45              


Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser Ile Asn Val Glu Leu 
    50                  55                  60                  


Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp Ser Ser Ser Leu Lys 
65                  70                  75                  80  


Thr Asp Leu Glu Leu Glu Tyr Lys Gln Thr Ala Asp Ser Ser Ala Arg 
                85                  90                  95      


Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe Val Leu Pro Asn Ala 
            100                 105                 110         


Gly Thr His Asn Glu Asn Tyr Ile Phe Gly Gln Cys Tyr Tyr Lys Ala 
        115                 120                 125             


Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr Val Met Leu Asn Lys 
    130                 135                 140                 


Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met Thr Phe Leu Trp Ser 
145                 150                 155                 160 


Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln Ala Thr Leu Ile Thr 
                165                 170                 175     


Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp Asp 
            180                 185             


<210>  7
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn Cys Ile Ile Glu Tyr 
1               5                   10                  15      


Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu Ile Leu Val Lys Asn 
            20                  25                  30          


Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met Gly Ala Ser Asp Tyr 
        35                  40                  45              


Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser Ile Asn Val Glu Leu 
    50                  55                  60                  


Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp Ser Ser Ser Leu Lys 
65                  70                  75                  80  


Thr Asp Leu Glu Leu Lys Tyr Lys Gln Thr Ala Asp Phe Ser Ala Arg 
                85                  90                  95      


Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe Val Leu Pro Asn Ala 
            100                 105                 110         


Gly Thr His Asn Glu Asn Tyr Ile Phe Gly Gln Cys Tyr Tyr Lys Ala 
        115                 120                 125             


Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr Val Met Leu Asn Lys 
    130                 135                 140                 


Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met Thr Phe Leu Trp Ser 
145                 150                 155                 160 


Leu Ser Ala Gly Leu Ala Pro Glu Thr Thr Gln Ala Thr Leu Ile Thr 
                165                 170                 175     


Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp Asp 
            180                 185             


<210>  8
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn Cys Ile Ile Glu Tyr 
1               5                   10                  15      


Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu Ile Leu Val Lys Asn 
            20                  25                  30          


Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met Gly Ala Ser Asp Tyr 
        35                  40                  45              


Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser Ile Asn Val Glu Leu 
    50                  55                  60                  


Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp Ser Ser Ser Leu Lys 
65                  70                  75                  80  


Thr Asp Leu Glu Leu Lys Tyr Lys Gln Thr Ala Asp Phe Ser Ala Arg 
                85                  90                  95      


Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe Asp Leu Pro Asn Ala 
            100                 105                 110         


Gly Thr His Asn Glu Asn Tyr Ile Phe Gly Gln Cys Tyr Tyr Lys Ala 
        115                 120                 125             


Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr Val Met Leu Asn Lys 
    130                 135                 140                 


Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met Thr Phe Leu Trp Ser 
145                 150                 155                 160 


Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln Ala Thr Leu Ile Thr 
                165                 170                 175     


Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp Asp 
            180                 185             


<210>  9
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  9

Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn Cys Ile Ile Glu Tyr 
1               5                   10                  15      


Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu Ile Leu Val Lys Asn 
            20                  25                  30          


Gly Gly Leu Val Asn Gly Tyr Val Thr Leu Met Gly Ala Ser Asp Tyr 
        35                  40                  45              


Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser Ile Asn Val Glu Leu 
    50                  55                  60                  


Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp Ser Ser Ser Leu Lys 
65                  70                  75                  80  


Thr Asp Leu Glu Pro Lys Tyr Lys Gln Thr Ala Asp Phe Ser Ala Arg 
                85                  90                  95      


Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe Val Leu Pro Asn Ala 
            100                 105                 110         


Gly Thr His Asn Glu Asn Tyr Ile Phe Gly Gln Cys Tyr Tyr Glu Ala 
        115                 120                 125             


Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr Val Met Leu Asn Lys 
    130                 135                 140                 


Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met Thr Phe Leu Trp Ser 
145                 150                 155                 160 


Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln Ala Thr Leu Ile Thr 
                165                 170                 175     


Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp Asp 
            180                 185             


<210>  10
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn Cys Ile Ile Glu Tyr 
1               5                   10                  15      


Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu Ile Leu Val Lys Asn 
            20                  25                  30          


Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met Gly Ala Ser Asp Tyr 
        35                  40                  45              


Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser Ile Asn Val Glu Leu 
    50                  55                  60                  


Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp Ser Ser Ser Leu Lys 
65                  70                  75                  80  


Thr Asp Leu Glu Leu Lys Tyr Lys Gln Thr Ala Asp Leu Ser Ala Arg 
                85                  90                  95      


Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe Val Leu Pro Asn Ala 
            100                 105                 110         


Gly Thr His Asn Glu Asn Tyr Ile Phe Gly Gln Cys Tyr Tyr Lys Ala 
        115                 120                 125             


Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr Val Met Leu Asn Lys 
    130                 135                 140                 


Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met Thr Phe Leu Trp Ser 
145                 150                 155                 160 


Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln Ala Thr Leu Ile Thr 
                165                 170                 175     


Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp Asp 
            180                 185             


<210>  11
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  11

Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn Cys Ile Ile Glu Tyr 
1               5                   10                  15      


Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu Ile Leu Val Lys Asn 
            20                  25                  30          


Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met Gly Ala Ser Asp Tyr 
        35                  40                  45              


Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser Ile Asn Val Glu Leu 
    50                  55                  60                  


Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp Ser Ser Ser Leu Lys 
65                  70                  75                  80  


Thr Asp Leu Glu Leu Lys Tyr Lys Gln Thr Ala Asp Phe Ser Ala Arg 
                85                  90                  95      


Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe Val Leu Pro Asn Ala 
            100                 105                 110         


Gly Thr His Asn Gly Asn Tyr Ile Phe Gly Gln Cys Tyr Tyr Glu Ala 
        115                 120                 125             


Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr Val Met Leu Asn Lys 
    130                 135                 140                 


Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met Thr Phe Leu Trp Ser 
145                 150                 155                 160 


Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln Ala Thr Leu Ile Thr 
                165                 170                 175     


Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp Asp 
            180                 185             


<210>  12
<211>  91
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is L or V

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is T or N

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is G or S

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is G or S

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is D or T

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is D or N

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is T, F or S

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  X is Q, K or E

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is G, K or S

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X is T or N

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  X is T or V

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  X is G or N

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  X is G or N

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X is S or P

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  X is A, P or N

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  X is G or Q

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  X is T or I

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  X is D or E

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  X is Q or E

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  X is T, S or A

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  X is E, Q or N

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  X is N or D

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  X is I or S

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is I or C

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  X is I or A

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  X is D, N or L

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  X is D or K

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  X is I or absent

<400>  12

Gly Val Leu Xaa Leu Lys Cys Xaa Xaa Pro Leu Thr Thr Xaa Xaa Gly 
1               5                   10                  15      


Ser Leu Gln Leu Lys Val Gly Xaa Gly Leu Thr Val Asp Xaa Thr Xaa 
            20                  25                  30          


Gly Xaa Leu Xaa Glu Asn Ile Xaa Xaa Xaa Thr Pro Leu Xaa Lys Xaa 
        35                  40                  45              


Xaa His Ser Ile Xaa Leu Xaa Xaa Gly Xaa Gly Leu Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Asn Lys Leu Cys Xaa Lys Leu Gly Xaa Gly Leu Thr Phe Xaa Ser Xaa 
65                  70                  75                  80  


Asn Xaa Xaa Xaa Xaa Xaa Asn Xaa Asn Thr Leu 
                85                  90      


<210>  13

<400>  13
000

<210>  14
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  14

Asn Gly Val Leu Ser Leu Lys Cys Val Asn Pro Leu Thr Thr Ala Ser 
1               5                   10                  15      


Gly Ser Leu Gln Leu Lys Val Gly Ser Gly Leu Thr Val Asp Thr Thr 
            20                  25                  30          


Asp Gly Ser Leu Glu Glu Asn Ile Lys Val Asn Thr Pro Leu Thr Lys 
        35                  40                  45              


Ser Asn His Ser Ile Asn Leu Pro Ile Gly Asn Gly Leu Gln Ile Glu 
    50                  55                  60                  


Gln Asn Lys Leu Cys Ser Lys Leu Gly Asn Gly Leu Thr Phe Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Ile Ala Leu Lys Asn Asn Thr Leu 
                85                  90      


<210>  15
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Gly Val Leu Thr Leu Lys Cys Leu Thr Pro Leu Thr Thr Thr Gly 
1               5                   10                  15      


Gly Ser Leu Gln Leu Lys Val Gly Gly Gly Leu Thr Ile Asp Asp Thr 
            20                  25                  30          


Asp Gly Phe Leu Lys Glu Asn Ile Ser Ala Thr Thr Pro Leu Val Lys 
        35                  40                  45              


Thr Gly His Ser Ile Gly Leu Ser Leu Gly Pro Gly Leu Gly Thr Asn 
    50                  55                  60                  


Glu Asn Lys Leu Cys Ala Lys Leu Gly Glu Gly Leu Thr Phe Asn Ser 
65                  70                  75                  80  


Asn Asn Ile Cys Ile Asn Asp Asn Ile Asn Thr Leu 
                85                  90          


<210>  16
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  16

Asn Gly Val Leu Thr Leu Lys Cys Leu Thr Pro Leu Thr Thr Thr Gly 
1               5                   10                  15      


Gly Ser Leu Gln Leu Lys Val Gly Gly Gly Leu Thr Val Asp Asp Thr 
            20                  25                  30          


Asn Gly Phe Leu Lys Glu Asn Ile Ser Ala Thr Thr Pro Leu Val Lys 
        35                  40                  45              


Thr Gly His Ser Ile Gly Leu Pro Leu Gly Ala Gly Leu Gly Thr Asn 
    50                  55                  60                  


Glu Asn Lys Leu Cys Ile Lys Leu Gly Gln Gly Leu Thr Phe Asn Ser 
65                  70                  75                  80  


Asn Asn Ile Cys Ile Asp Asp Asn Ile Asn Thr Leu 
                85                  90          


<210>  17
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Val Leu Thr Leu Lys Cys Leu Thr Pro Leu Thr Thr Thr Gly Gly 
1               5                   10                  15      


Ser Leu Gln Leu Lys Val Gly Gly Gly Leu Thr Val Asp Asp Thr Asp 
            20                  25                  30          


Gly Thr Leu Gln Glu Asn Ile Gly Ala Thr Thr Pro Leu Val Lys Thr 
        35                  40                  45              


Gly His Ser Ile Gly Leu Ser Leu Gly Ala Gly Leu Gly Thr Asp Glu 
    50                  55                  60                  


Asn Lys Leu Cys Thr Lys Leu Gly Glu Gly Leu Thr Phe Asn Ser Asn 
65                  70                  75                  80  


Asn Ile Cys Ile Asp Asp Asn Ile Asn Thr Leu 
                85                  90      


<210>  18
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Gly Val Leu Thr Leu Lys Cys Leu Thr Pro Leu Thr Thr Thr Gly 
1               5                   10                  15      


Gly Ser Leu Gln Leu Lys Val Gly Gly Gly Leu Thr Val Asp Asp Thr 
            20                  25                  30          


Asp Gly Thr Leu Gln Glu Asn Ile Gly Ala Thr Thr Pro Leu Val Lys 
        35                  40                  45              


Thr Gly His Ser Ile Gly Leu Ser Leu Gly Ala Gly Leu Gly Thr Asp 
    50                  55                  60                  


Glu Asn Lys Leu Cys Thr Lys Leu Gly Glu Gly Leu Thr Phe Asn Ser 
65                  70                  75                  80  


Asn Asn Ile Cys Ile Asp Asp Asn Ile Asn Thr Leu 
                85                  90          


<210>  19
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Phe Leu Val Ile Tyr Ile Glu Glu Ala His Ala Ser Asp Gly Trp 
1               5                   10                  15      


<210>  20
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Asp Phe Leu Tyr Ile Glu Ala His Asp Gly Trp 
1               5                   10          


<210>  21
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Gly Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys 
1               5                   10                  15      


Thr Leu Arg Ala 
            20  


<210>  22
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  22

His Met Lys Gln Leu Asp Val Glu Glu Leu Ser Asn Tyr His Leu Asn 
1               5                   10                  15      


Val Ala Arg Leu Lys Val Gly Glu Arg 
            20                  25  


<210>  23
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Val Thr Gln Leu Met Arg Glu Met Leu Gln Leu Ile Lys Phe Gln 
1               5                   10                  15      


Phe Ser Leu Asn Tyr Gln Glu Glu Ser Leu Ser Tyr Gln Arg Leu Val 
            20                  25                  30          


Thr 
    


<210>  24
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Val Ser Ala Leu Glu Lys 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys Val Ser Ala Leu Lys Glu 
1               5           


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Gly Gly Gly Ser 
1               


<210>  27
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys 
1               5                   10                  15      


Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser 
            20                  25                  30          


Ala Leu Lys Glu Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Ser Asn Ser Ile Ala Leu Lys Asn Asn Thr Leu Trp Thr Gly Pro 
    50                  55                  60                  


Lys Pro Glu Ala Asn Cys Ile Ile Glu Tyr Gly Lys Gln Asn Pro Asp 
65                  70                  75                  80  


Ser Lys Leu Thr Leu Ile Leu Val Lys Asn Gly Gly Ile Val Asn Gly 
                85                  90                  95      


Tyr Val Thr Leu Met Gly Ala Ser Asp Tyr Val Asn Thr Leu Phe Lys 
            100                 105                 110         


Asn Lys Asn Val Ser Ile Asn Val Glu Leu Tyr Phe Asp Ala Thr Gly 
        115                 120                 125             


His Ile Leu Pro Asp Ser Ser Ser Leu Lys Thr Asp Leu Glu Leu Lys 
    130                 135                 140                 


Tyr Lys Gln Thr Ala Asp Phe Ser Ala Arg Gly Phe Met Pro Ser Thr 
145                 150                 155                 160 


Thr Ala Tyr Pro Phe Val Leu Pro Asn Ala Gly Thr His Asn Glu Asn 
                165                 170                 175     


Tyr Ile Phe Gly Gln Cys Tyr Tyr Lys Ala Ser Asp Gly Ala Leu Phe 
            180                 185                 190         


Pro Leu Glu Val Thr Val Met Leu Asn Lys Arg Leu Pro Asp Ser Arg 
        195                 200                 205             


Thr Ser Tyr Val Met Thr Phe Leu Trp Ser Leu Asn Ala Gly Leu Ala 
    210                 215                 220                 


Pro Glu Thr Thr Gln Ala Thr Leu Ile Thr Ser Pro Phe Thr Phe Ser 
225                 230                 235                 240 


Tyr Ile Arg Glu Asp Asp 
                245     


<210>  28
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Gly Ser His His His His His His Gly Ser Lys Val Ser Ala 
1               5                   10                  15      


Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys 
            20                  25                  30          


Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Gly 
        35                  40                  45              


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Ser Ile 
    50                  55                  60                  


Ala Leu Lys Asn Asn Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn 
65                  70                  75                  80  


Cys Ile Ile Glu Tyr Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu 
                85                  90                  95      


Ile Leu Val Lys Asn Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met 
            100                 105                 110         


Gly Ala Ser Asp Tyr Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser 
        115                 120                 125             


Ile Asn Val Glu Leu Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp 
    130                 135                 140                 


Ser Ser Ser Leu Lys Thr Asp Leu Glu Leu Lys Tyr Lys Gln Thr Ala 
145                 150                 155                 160 


Asp Phe Ser Ala Arg Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe 
                165                 170                 175     


Val Leu Pro Asn Ala Gly Thr His Asn Glu Asn Phe Ile Phe Gly Gln 
            180                 185                 190         


Cys Tyr Tyr Lys Ala Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr 
        195                 200                 205             


Val Met Leu Asn Lys Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met 
    210                 215                 220                 


Thr Phe Leu Trp Ser Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln 
225                 230                 235                 240 


Ala Thr Leu Ile Thr Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp 
                245                 250                 255     


Asp 
    


<210>  29
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Gly Ser His His His His His His Gly Ser Lys Val Ser Ala 
1               5                   10                  15      


Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys 
            20                  25                  30          


Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Gly 
        35                  40                  45              


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Ser Ile 
    50                  55                  60                  


Ala Leu Lys Asn Asn Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn 
65                  70                  75                  80  


Cys Ile Ile Glu Tyr Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu 
                85                  90                  95      


Ile Leu Val Lys Asn Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met 
            100                 105                 110         


Gly Ala Ser Asp Tyr Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser 
        115                 120                 125             


Ile Asn Val Glu Leu Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp 
    130                 135                 140                 


Ser Ser Ser Leu Lys Thr Asp Leu Glu Leu Glu Tyr Lys Gln Thr Ala 
145                 150                 155                 160 


Asp Ser Ser Ala Arg Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe 
                165                 170                 175     


Val Leu Pro Asn Ala Gly Thr His Asn Glu Asn Tyr Ile Phe Gly Gln 
            180                 185                 190         


Cys Tyr Tyr Lys Ala Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr 
        195                 200                 205             


Val Met Leu Asn Lys Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met 
    210                 215                 220                 


Thr Phe Leu Trp Ser Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln 
225                 230                 235                 240 


Ala Thr Leu Ile Thr Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp 
                245                 250                 255     


Asp 
    


<210>  30
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Gly Ser His His His His His His Gly Ser Lys Val Ser Ala 
1               5                   10                  15      


Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys 
            20                  25                  30          


Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Gly 
        35                  40                  45              


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Ser Ile 
    50                  55                  60                  


Ala Leu Lys Asn Asn Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn 
65                  70                  75                  80  


Cys Ile Ile Glu Tyr Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu 
                85                  90                  95      


Ile Leu Val Lys Asn Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met 
            100                 105                 110         


Gly Ala Ser Asp Tyr Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser 
        115                 120                 125             


Ile Asn Val Glu Leu Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp 
    130                 135                 140                 


Ser Ser Ser Leu Lys Thr Asp Leu Glu Leu Lys Tyr Lys Gln Thr Ala 
145                 150                 155                 160 


Asp Phe Ser Ala Arg Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe 
                165                 170                 175     


Val Leu Pro Asn Ala Gly Thr His Asn Glu Asn Tyr Ile Phe Gly Gln 
            180                 185                 190         


Cys Tyr Tyr Lys Ala Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr 
        195                 200                 205             


Val Met Leu Asn Lys Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met 
    210                 215                 220                 


Thr Phe Leu Trp Ser Leu Ser Ala Gly Leu Ala Pro Glu Thr Thr Gln 
225                 230                 235                 240 


Ala Thr Leu Ile Thr Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp 
                245                 250                 255     


Asp 
    


<210>  31
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Arg Gly Ser His His His His His His Gly Ser Lys Val Ser Ala 
1               5                   10                  15      


Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys 
            20                  25                  30          


Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Gly 
        35                  40                  45              


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Ser Ile 
    50                  55                  60                  


Ala Leu Lys Asn Asn Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn 
65                  70                  75                  80  


Cys Ile Ile Glu Tyr Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu 
                85                  90                  95      


Ile Leu Val Lys Asn Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met 
            100                 105                 110         


Gly Ala Ser Asp Tyr Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser 
        115                 120                 125             


Ile Asn Val Glu Leu Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp 
    130                 135                 140                 


Ser Ser Ser Leu Lys Thr Asp Leu Glu Leu Lys Tyr Lys Gln Thr Ala 
145                 150                 155                 160 


Asp Phe Ser Ala Arg Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe 
                165                 170                 175     


Asp Leu Pro Asn Ala Gly Thr His Asn Glu Asn Tyr Ile Phe Gly Gln 
            180                 185                 190         


Cys Tyr Tyr Lys Ala Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr 
        195                 200                 205             


Val Met Leu Asn Lys Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met 
    210                 215                 220                 


Thr Phe Leu Trp Ser Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln 
225                 230                 235                 240 


Ala Thr Leu Ile Thr Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp 
                245                 250                 255     


Asp 
    


<210>  32
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Arg Gly Ser His His His His His His Gly Ser Lys Val Ser Ala 
1               5                   10                  15      


Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys 
            20                  25                  30          


Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Gly 
        35                  40                  45              


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Ser Ile 
    50                  55                  60                  


Ala Leu Lys Asn Asn Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn 
65                  70                  75                  80  


Cys Ile Ile Glu Tyr Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu 
                85                  90                  95      


Ile Leu Val Lys Asn Gly Gly Leu Val Asn Gly Tyr Val Thr Leu Met 
            100                 105                 110         


Gly Ala Ser Asp Tyr Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser 
        115                 120                 125             


Ile Asn Val Glu Leu Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp 
    130                 135                 140                 


Ser Ser Ser Leu Lys Thr Asp Leu Glu Pro Lys Tyr Lys Gln Thr Ala 
145                 150                 155                 160 


Asp Phe Ser Ala Arg Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe 
                165                 170                 175     


Val Leu Pro Asn Ala Gly Thr His Asn Glu Asn Tyr Ile Phe Gly Gln 
            180                 185                 190         


Cys Tyr Tyr Glu Ala Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr 
        195                 200                 205             


Val Met Leu Asn Lys Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met 
    210                 215                 220                 


Thr Phe Leu Trp Ser Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln 
225                 230                 235                 240 


Ala Thr Leu Ile Thr Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp 
                245                 250                 255     


Asp 
    


<210>  33
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Arg Gly Ser His His His His His His Gly Ser Lys Val Ser Ala 
1               5                   10                  15      


Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys 
            20                  25                  30          


Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Gly 
        35                  40                  45              


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Ser Ile 
    50                  55                  60                  


Ala Leu Lys Asn Asn Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn 
65                  70                  75                  80  


Cys Ile Ile Glu Tyr Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu 
                85                  90                  95      


Ile Leu Val Lys Asn Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met 
            100                 105                 110         


Gly Ala Ser Asp Tyr Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser 
        115                 120                 125             


Ile Asn Val Glu Leu Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp 
    130                 135                 140                 


Ser Ser Ser Leu Lys Thr Asp Leu Glu Leu Lys Tyr Lys Gln Thr Ala 
145                 150                 155                 160 


Asp Leu Ser Ala Arg Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe 
                165                 170                 175     


Val Leu Pro Asn Ala Gly Thr His Asn Glu Asn Tyr Ile Phe Gly Gln 
            180                 185                 190         


Cys Tyr Tyr Lys Ala Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr 
        195                 200                 205             


Val Met Leu Asn Lys Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met 
    210                 215                 220                 


Thr Phe Leu Trp Ser Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln 
225                 230                 235                 240 


Ala Thr Leu Ile Thr Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp 
                245                 250                 255     


Asp 
    


<210>  34
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Gly Ser His His His His His His Gly Ser Lys Val Ser Ala 
1               5                   10                  15      


Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys 
            20                  25                  30          


Glu Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Gly 
        35                  40                  45              


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Ser Ile 
    50                  55                  60                  


Ala Leu Lys Asn Asn Thr Leu Trp Thr Gly Pro Lys Pro Glu Ala Asn 
65                  70                  75                  80  


Cys Ile Ile Glu Tyr Gly Lys Gln Asn Pro Asp Ser Lys Leu Thr Leu 
                85                  90                  95      


Ile Leu Val Lys Asn Gly Gly Ile Val Asn Gly Tyr Val Thr Leu Met 
            100                 105                 110         


Gly Ala Ser Asp Tyr Val Asn Thr Leu Phe Lys Asn Lys Asn Val Ser 
        115                 120                 125             


Ile Asn Val Glu Leu Tyr Phe Asp Ala Thr Gly His Ile Leu Pro Asp 
    130                 135                 140                 


Ser Ser Ser Leu Lys Thr Asp Leu Glu Leu Lys Tyr Lys Gln Thr Ala 
145                 150                 155                 160 


Asp Phe Ser Ala Arg Gly Phe Met Pro Ser Thr Thr Ala Tyr Pro Phe 
                165                 170                 175     


Val Leu Pro Asn Ala Gly Thr His Asn Gly Asn Tyr Ile Phe Gly Gln 
            180                 185                 190         


Cys Tyr Tyr Glu Ala Ser Asp Gly Ala Leu Phe Pro Leu Glu Val Thr 
        195                 200                 205             


Val Met Leu Asn Lys Arg Leu Pro Asp Ser Arg Thr Ser Tyr Val Met 
    210                 215                 220                 


Thr Phe Leu Trp Ser Leu Asn Ala Gly Leu Ala Pro Glu Thr Thr Gln 
225                 230                 235                 240 


Ala Thr Leu Ile Thr Ser Pro Phe Thr Phe Ser Tyr Ile Arg Glu Asp 
                245                 250                 255     


Asp 
    


<210>  35
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
atcacggatc cggtggcggt tctggcggtg gctccggtgg cggttctaac aaactttgca       60

gtaaactc                                                                68


<210>  36
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
ctcagctaat taagcttagt catcttctct aatatagga                              39


<210>  37
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
ccaattctat tgcacttaag aataacactt tatggacagg t                           41


<210>  38
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
gtccaagctc agctaattaa gcttagtcat cttc                                   34


<210>  39
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
catcacggat ccggtggcgg ttctggcggt ggctccggtg gcggttctaa taaactttgt       60

accaaattgg gagaagg                                                      77


<210>  40
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
gctaattaag cttagtcgtc ttctctgatg tagtaaaagg                             40


