б

<110>  ˣ, ά.ɭ, Ӧ

<120>  PI3K-AKT-mTORźͨ·ҩͷ

<130>  PCTF1301

<150>  CN201210379418.9
<151>  2012-09-29

<160>  6  
  
<170>  PatentIn version 3.3

<210>  1
<211>  496
<212>  PRT
<213>  NP_005031 PRCP

<400>  1

Met Gly Arg Arg Ala Leu Leu Leu Leu Leu Leu Ser Phe Leu Ala Pro 
1               5                   10                  15      

Trp Ala Thr Ile Ala Leu Arg Pro Ala Leu Arg Ala Leu Gly Ser Leu 
            20                  25                  30          

His Leu Pro Thr Asn Pro Thr Ser Leu Pro Ala Val Ala Lys Asn Tyr 
        35                  40                  45              

Ser Val Leu Tyr Phe Gln Gln Lys Val Asp His Phe Gly Phe Asn Thr 
    50                  55                  60                  

Val Lys Thr Phe Asn Gln Arg Tyr Leu Val Ala Asp Lys Tyr Trp Lys 
65                  70                  75                  80  

Lys Asn Gly Gly Ser Ile Leu Phe Tyr Thr Gly Asn Glu Gly Asp Ile 
                85                  90                  95      

Ile Trp Phe Cys Asn Asn Thr Gly Phe Met Trp Asp Val Ala Glu Glu 
            100                 105                 110         

Leu Lys Ala Met Leu Val Phe Ala Glu His Arg Tyr Tyr Gly Glu Ser 
        115                 120                 125             

Leu Pro Phe Gly Asp Asn Ser Phe Lys Asp Ser Arg His Leu Asn Phe 
    130                 135                 140                 

Leu Thr Ser Glu Gln Ala Leu Ala Asp Phe Ala Glu Leu Ile Lys His 
145                 150                 155                 160 

Leu Lys Arg Thr Ile Pro Gly Ala Glu Asn Gln Pro Val Ile Ala Ile 
                165                 170                 175     

Gly Gly Ser Tyr Gly Gly Met Leu Ala Ala Trp Phe Arg Met Lys Tyr 
            180                 185                 190         

Pro His Met Val Val Gly Ala Leu Ala Ala Ser Ala Pro Ile Trp Gln 
        195                 200                 205             

Phe Glu Asp Leu Val Pro Cys Gly Val Phe Met Lys Ile Val Thr Thr 
    210                 215                 220                 

Asp Phe Arg Lys Ser Gly Pro His Cys Ser Glu Ser Ile His Arg Ser 
225                 230                 235                 240 

Trp Asp Ala Ile Asn Arg Leu Ser Asn Thr Gly Ser Gly Leu Gln Trp 
                245                 250                 255     

Leu Thr Gly Ala Leu His Leu Cys Ser Pro Leu Thr Ser Gln Asp Ile 
            260                 265                 270         

Gln His Leu Lys Asp Trp Ile Ser Glu Thr Trp Val Asn Leu Ala Met 
        275                 280                 285             

Val Asp Tyr Pro Tyr Ala Ser Asn Phe Leu Gln Pro Leu Pro Ala Trp 
    290                 295                 300                 

Pro Ile Lys Val Val Cys Gln Tyr Leu Lys Asn Pro Asn Val Ser Asp 
305                 310                 315                 320 

Ser Leu Leu Leu Gln Asn Ile Phe Gln Ala Leu Asn Val Tyr Tyr Asn 
                325                 330                 335     

Tyr Ser Gly Gln Val Lys Cys Leu Asn Ile Ser Glu Thr Ala Thr Ser 
            340                 345                 350         

Ser Leu Gly Thr Leu Gly Trp Ser Tyr Gln Ala Cys Thr Glu Val Val 
        355                 360                 365             

Met Pro Phe Cys Thr Asn Gly Val Asp Asp Met Phe Glu Pro His Ser 
    370                 375                 380                 

Trp Asn Leu Lys Glu Leu Ser Asp Asp Cys Phe Gln Gln Trp Gly Val 
385                 390                 395                 400 

Arg Pro Arg Pro Ser Trp Ile Thr Thr Met Tyr Gly Gly Lys Asn Ile 
                405                 410                 415     

Ser Ser His Thr Asn Ile Val Phe Ser Asn Gly Glu Leu Asp Pro Trp 
            420                 425                 430         

Ser Gly Gly Gly Val Thr Lys Asp Ile Thr Asp Thr Leu Val Ala Val 
        435                 440                 445             

Thr Ile Ser Glu Gly Ala His His Leu Asp Leu Arg Thr Lys Asn Ala 
    450                 455                 460                 

Leu Asp Pro Met Ser Val Leu Leu Ala Arg Ser Leu Glu Val Arg His 
465                 470                 475                 480 

Met Lys Asn Trp Ile Arg Asp Phe Tyr Asp Ser Ala Gly Lys Gln His 
                485                 490                 495     


<210>  2
<211>  710
<212>  PRT
<213>  NP_002717 PREP

<400>  2

Met Leu Ser Leu Gln Tyr Pro Asp Val Tyr Arg Asp Glu Thr Ala Val 
1               5                   10                  15      

Gln Asp Tyr His Gly His Lys Ile Cys Asp Pro Tyr Ala Trp Leu Glu 
            20                  25                  30          

Asp Pro Asp Ser Glu Gln Thr Lys Ala Phe Val Glu Ala Gln Asn Lys 
        35                  40                  45              

Ile Thr Val Pro Phe Leu Glu Gln Cys Pro Ile Arg Gly Leu Tyr Lys 
    50                  55                  60                  

Glu Arg Met Thr Glu Leu Tyr Asp Tyr Pro Lys Tyr Ser Cys His Phe 
65                  70                  75                  80  

Lys Lys Gly Lys Arg Tyr Phe Tyr Phe Tyr Asn Thr Gly Leu Gln Asn 
                85                  90                  95      

Gln Arg Val Leu Tyr Val Gln Asp Ser Leu Glu Gly Glu Ala Arg Val 
            100                 105                 110         

Phe Leu Asp Pro Asn Ile Leu Ser Asp Asp Gly Thr Val Ala Leu Arg 
        115                 120                 125             

Gly Tyr Ala Phe Ser Glu Asp Gly Glu Tyr Phe Ala Tyr Gly Leu Ser 
    130                 135                 140                 

Ala Ser Gly Ser Asp Trp Val Thr Ile Lys Phe Met Lys Val Asp Gly 
145                 150                 155                 160 

Ala Lys Glu Leu Pro Asp Val Leu Glu Arg Val Lys Phe Ser Cys Met 
                165                 170                 175     

Ala Trp Thr His Asp Gly Lys Gly Met Phe Tyr Asn Ser Tyr Pro Gln 
            180                 185                 190         

Gln Asp Gly Lys Ser Asp Gly Thr Glu Thr Ser Thr Asn Leu His Gln 
        195                 200                 205             

Lys Leu Tyr Tyr His Val Leu Gly Thr Asp Gln Ser Glu Asp Ile Leu 
    210                 215                 220                 

Cys Ala Glu Phe Pro Asp Glu Pro Lys Trp Met Gly Gly Ala Glu Leu 
225                 230                 235                 240 

Ser Asp Asp Gly Arg Tyr Val Leu Leu Ser Ile Arg Glu Gly Cys Asp 
                245                 250                 255     

Pro Val Asn Arg Leu Trp Tyr Cys Asp Leu Gln Gln Glu Ser Ser Gly 
            260                 265                 270         

Ile Ala Gly Ile Leu Lys Trp Val Lys Leu Ile Asp Asn Phe Glu Gly 
        275                 280                 285             

Glu Tyr Asp Tyr Val Thr Asn Glu Gly Thr Val Phe Thr Phe Lys Thr 
    290                 295                 300                 

Asn Arg Gln Ser Pro Asn Tyr Arg Val Ile Asn Ile Asp Phe Arg Asp 
305                 310                 315                 320 

Pro Glu Glu Ser Lys Trp Lys Val Leu Val Pro Glu His Glu Lys Asp 
                325                 330                 335     

Val Leu Glu Trp Ile Ala Cys Val Arg Ser Asn Phe Leu Val Leu Cys 
            340                 345                 350         

Tyr Leu His Asp Val Lys Asn Ile Leu Gln Leu His Asp Leu Thr Thr 
        355                 360                 365             

Gly Ala Leu Leu Lys Thr Phe Pro Leu Asp Val Gly Ser Ile Val Gly 
    370                 375                 380                 

Tyr Ser Gly Gln Lys Lys Asp Thr Glu Ile Phe Tyr Gln Phe Thr Ser 
385                 390                 395                 400 

Phe Leu Ser Pro Gly Ile Ile Tyr His Cys Asp Leu Thr Lys Glu Glu 
                405                 410                 415     

Leu Glu Pro Arg Val Phe Arg Glu Val Thr Val Lys Gly Ile Asp Ala 
            420                 425                 430         

Ser Asp Tyr Gln Thr Val Gln Ile Phe Tyr Pro Ser Lys Asp Gly Thr 
        435                 440                 445             

Lys Ile Pro Met Phe Ile Val His Lys Lys Gly Ile Lys Leu Asp Gly 
    450                 455                 460                 

Ser His Pro Ala Phe Leu Tyr Gly Tyr Gly Gly Phe Asn Ile Ser Ile 
465                 470                 475                 480 

Thr Pro Asn Tyr Ser Val Ser Arg Leu Ile Phe Val Arg His Met Gly 
                485                 490                 495     

Gly Ile Leu Ala Val Ala Asn Ile Arg Gly Gly Gly Glu Tyr Gly Glu 
            500                 505                 510         

Thr Trp His Lys Gly Gly Ile Leu Ala Asn Lys Gln Asn Cys Phe Asp 
        515                 520                 525             

Asp Phe Gln Cys Ala Ala Glu Tyr Leu Ile Lys Glu Gly Tyr Thr Ser 
    530                 535                 540                 

Pro Lys Arg Leu Thr Ile Asn Gly Gly Ser Asn Gly Gly Leu Leu Val 
545                 550                 555                 560 

Ala Ala Cys Ala Asn Gln Arg Pro Asp Leu Phe Gly Cys Val Ile Ala 
                565                 570                 575     

Gln Val Gly Val Met Asp Met Leu Lys Phe His Lys Tyr Thr Ile Gly 
            580                 585                 590         

His Ala Trp Thr Thr Asp Tyr Gly Cys Ser Asp Ser Lys Gln His Phe 
        595                 600                 605             

Glu Trp Leu Val Lys Tyr Ser Pro Leu His Asn Val Lys Leu Pro Glu 
    610                 615                 620                 

Ala Asp Asp Ile Gln Tyr Pro Ser Met Leu Leu Leu Thr Ala Asp His 
625                 630                 635                 640 

Asp Asp Arg Val Val Pro Leu His Ser Leu Lys Phe Ile Ala Thr Leu 
                645                 650                 655     

Gln Tyr Ile Val Gly Arg Ser Arg Lys Gln Ser Asn Pro Leu Leu Ile 
            660                 665                 670         

His Val Asp Thr Lys Ala Gly His Gly Ala Gly Lys Pro Thr Ala Lys 
        675                 680                 685             

Val Ile Glu Glu Val Ser Asp Met Phe Ala Phe Ile Ala Arg Cys Leu 
    690                 695                 700                 

Asn Val Asp Trp Ile Pro 
705                 710 


<210>  3
<211>  23
<212>  DNA
<213>  PRCP

<400>  3
tctacactgg taatgaaggg gac                                     23


<210>  4
<211>  23
<212>  DNA
<213>  PRCP

<400>  4
tccttgaatg agttgtcacc aaa                                      23


<210>  5
<211>  21
<212>  DNA
<213>  PREP

<400>  5
gagaccgccg tacaggatta t                                         21


<210>  6
<211>  23
<212>  DNA
<213>  PREP

<400>  6
tgaagtggca actatacttg gga                                       23


