                         SEQUENCE LISTING

<110>  UNIVERSITY OF BRITISH COLUMBIA
 
<120>  PEPTIDE DIRECTED PROTEIN KNOCKDOWN

<130>  V86633WO

<140>  PCT/CA2013/050741
<141>  2013-09-27

<150>  US 61/706,506
<151>  2012-09-27

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Knockdown peptide targeting alpha-synuclein without TAT protein 
       transduction domain

<400>  1

Gly Val Leu Tyr Val Gly Ser Lys Thr Arg Lys Phe Glu Arg Gln Lys 
1               5                   10                  15      


Ile Leu Asp Gln Arg Phe Phe Glu 
            20                  


<210>  2
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Knockdown peptide targeting alpha-synuclein, with TAT protein 
       transduction domain

<400>  2

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Val Leu Tyr Val 
1               5                   10                  15      


Gly Ser Lys Thr Arg Lys Phe Glu Arg Gln Lys Ile Leu Asp Gln Arg 
            20                  25                  30          


Phe Phe Glu 
        35  


<210>  3
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Knockdown peptide targeting DAPK1, without TAT protein 
       transduction domain

<400>  3

Lys Lys Asn Arg Asn Lys Leu Arg Arg Gln His Ser Tyr Lys Phe Glu 
1               5                   10                  15      


Arg Gln Lys Ile Leu Asp Gln Arg Phe Phe Glu 
            20                  25          


<210>  4
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Knockdown peptide targeting DAPK1, with TAT protein transduction 
       domain

<400>  4

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Lys Asn Arg Asn 
1               5                   10                  15      


Lys Leu Arg Arg Gln His Ser Tyr Lys Phe Glu Arg Gln Lys Ile Leu 
            20                  25                  30          


Asp Gln Arg Phe Phe Glu 
        35              


<210>  5
<211>  13
<212>  PRT
<213>  Human influenza virus

<400>  5

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  6
<211>  15
<212>  PRT
<213>  Drosophila melanogaster

<400>  6

Arg Gln Ile Lys Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15  


<210>  7
<211>  21
<212>  PRT
<213>  Unknown

<220>
<223>  Buforin II cell-membrane penetrating domain

<400>  7

Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys 
            20      


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg 
1               5                   10              


<210>  9
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  Model amphipathic peptide cell-membrane penetrating domain

<400>  9

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  10
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  K-FGF cell-membrane penetrating domain

<400>  10

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  11
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Ku70-derived peptide cell-membrane penetrating domain

<400>  11

Val Pro Met Leu Lys Glu 
1               5       


<210>  12
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Ku70-derived peptide cell-membrane penetrating domain

<400>  12

Val Pro Met Leu Lys 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Ku70-derived peptide cell-membrane penetrating domain

<400>  13

Pro Met Leu Lys Glu 
1               5   


<210>  14
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Ku70-derived peptide cell-membrane penetrating domain

<400>  14

Pro Met Leu Lys 
1               


<210>  15
<211>  28
<212>  PRT
<213>  Unknown

<220>
<223>  Prion, Mouse Prpe  cell-membrane penetrating domain

<400>  15

Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Met Trp 
1               5                   10                  15      


Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro 
            20                  25              


<210>  16
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  pVEC cell-membrane penetrating domain

<400>  16

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  17
<211>  21
<212>  PRT
<213>  Unknown

<220>
<223>  Pep-I cell-membrane penetrating domain

<400>  17

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  18
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  SynBl cell-membrane penetrating domain

<400>  18

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  19
<211>  27
<212>  PRT
<213>  Unknown

<220>
<223>  Transportan cell-membrane penetrating domain

<400>  19

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  20
<211>  21
<212>  PRT
<213>  Unknown

<220>
<223>  Transportan-l0 cell-membrane penetrating domain

<400>  20

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  21
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  CADY cell-membrane penetrating domain

<400>  21

Gly Leu Trp Arg Ala Leu Trp Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Trp Arg Ala 
            20  


<210>  22
<211>  15
<212>  PRT
<213>  Unknown

<220>
<223>  Pep-7 cell-membrane penetrating domain

<400>  22

Ser Asp Leu Trp Glu Met Met Met Val Ser Leu Ala Cys Gln Tyr 
1               5                   10                  15  


<210>  23
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  HN-1 cell-membrane penetrating domain

<400>  23

Thr Ser Pro Leu Asn Ile His Asn Gly Gln Lys Leu 
1               5                   10          


<210>  24
<211>  26
<212>  PRT
<213>  Unknown

<220>
<223>  VT5 cell-membrane penetrating domain

<400>  24

Asp Pro Lys Gly Asp Pro Lys Gly Val Thr Val Thr Val Thr Val Thr 
1               5                   10                  15      


Val Thr Gly Lys Gly Asp Pro Lys Pro Asp 
            20                  25      


<210>  25
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  pISL cell-membrane penetrating domain

<400>  25

Arg Val Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys 
1               5                   10                  15      


<210>  26
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Chaperone-mediated autophagy targeting signal, pentapeptide motif

<400>  26

Lys Phe Glu Arg Gln 
1               5   


<210>  27
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  AHNP homing peptide conjugated to cell-penetrating peptide

<400>  27

Phe Cys Asp Gly Phe Tyr Ala Cys Tyr Lys Asp Val 
1               5                   10          


<210>  28
<211>  21
<212>  PRT
<213>  Unknown

<220>
<223>  DV1 homing peptide conjugated to cell-penetrating peptide

<400>  28

Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly Tyr Gln 
1               5                   10                  15      


Lys Arg Pro Leu Pro 
            20      


<210>  29
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  DV3 homing peptide conjugated to cell-penetrating peptide

<400>  29

Leu Gly Ala Ser Trp His Arg Pro Asp Lys 
1               5                   10  


<210>  30
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  PEGA homing peptide conjugated to cell-penetrating peptide

<400>  30

Cys Pro Gly Pro Glu Gly Ala Gly Cys 
1               5                   


<210>  31
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  CREKA homing peptide conjugated to cell-penetrating peptide

<400>  31

Cys Arg Glu Lys Ala 
1               5   


<210>  32
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  TCP-1 cell-penetrating homing peptide

<400>  32

Cys Thr Pro Ser Pro Phe Ser His Cys 
1               5                   


<210>  33
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  HAP-1 cell-penetrating homing peptide

<400>  33

Ser Phe His Gln Phe Ala Arg Ala Thr Leu Ala Ser 
1               5                   10          


<210>  34
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  HAP-2 cell-penetrating homing peptide

<400>  34

His Ile Gln Leu Ser Pro Phe Gln Ser Trp Arg 
1               5                   10      


<210>  35
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Cell-penetrating homing peptide

<400>  35

Pro Tyr Glu Glu 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Cell-penetrating homing peptide

<400>  36

Leu Lys Lys Pro 
1               

<400>  37

Glu Pro Lys Xaa 
1               


<210>  38
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Cell penetrating homing peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  N-alkyl glycine lysine-like peptoid

<400>  38

Glu Leu Xaa Xaa 
1               


<210>  39
<211>  32
<212>  PRT
<213>  Unknown

<220>
<223>  F3 cell-penetrating homing peptide

<400>  39

Cys Lys Asp Glu Pro Gln Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro 
1               5                   10                  15      


Ala Pro Pro Lys Pro Glu Pro Lys Pro Lys Lys Ala Pro Ala Lys Lys 
            20                  25                  30          


<210>  40
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  Pep42 cell-penetrating homing peptide

<400>  40

Cys Thr Val Ala Leu Pro Gly Gly Tyr Val Arg Val Cys 
1               5                   10              


<210>  41
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  CAP cell-penetrating homing peptide

<400>  41

Asp Trp Arg Val Ile Ile Pro Pro Arg Pro Ser Ala 
1               5                   10          


<210>  42
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  RGD-4C cell-penetrating homing peptide

<400>  42

Cys Asp Cys Arg Gly Asp Cys Phe Cys 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  iRGD cell-penetrating homing peptide

<400>  43

Cys Arg Gly Asp Lys Gly Pro Asp Cys 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  iRGD cell-penetrating homing peptide

<400>  44

Cys Arg Gly Asp Arg Gly Pro Asp Cys 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  iRGD cell-penetrating homing peptide

<400>  45

Cys Arg Gly Asp Lys Gly Pro Glu Cys 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  iRGD cell-penetrating homing peptide

<400>  46

Cys Arg Gly Asp Arg Gly Pro Glu Cys 
1               5                   


<210>  47
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Chaperone-mediated autophagy targeting signal identified from 
       Rnase A

<400>  47

Lys Phe Glu Arg Gln 
1               5   


<210>  48
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Chaperone-mediated autophagy targeting signal identified from 
       hsc70

<400>  48

Gln Lys Ile Leu Asp 
1               5   


<210>  49
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Chaperone-mediated autophagy targeting signal identified from 
       Hemoglobin

<400>  49

Gln Arg Phe Phe Glu 
1               5   


<210>  50
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  cRGDF cell-penetrating homing peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  METHYLATION, MeVal

<400>  50

Arg Gly Asp Phe Xaa 
1               5   


