                               SEQUENCE LISTING

<110> GENENTECH, INC. ET AL.
 
<120> METHODS AND COMPOSITIONS FOR PREVENTING NORLEUCINE 
      MISINCORPORATION INTO PROTEINS

<130> P4967R1-WO

<140>
<141>

<150> 61/777,700
<151> 2013-03-12

<150> 61/703,142
<151> 2012-09-19

<160> 52    

<170> PatentIn version 3.5

<210> 1
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1
cacacgagct cctcattttg ctcattaacg ttgg                                   34


<210> 2
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 2
cacacgtcga cgcgaatgga agctg                                             25


<210> 3
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 3
cacacgagct cgtatgcaaa gcagagatgc                                        30


<210> 4
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 4
cacacgtcga ccgtcattgc cttgtttg                                          28


<210> 5
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 5
gttctgatcc ttaacctgat gccgaagaag                                        30


<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 6
ccagcgtttg cgcatcatat tcgg                                              24


<210> 7
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 7
ggcaaaacac ctttttacgt ccgagtcc                                          28


<210> 8
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 8
gaactcacgt accagcaggg tcagttg                                           27


<210> 9
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 9
ccagtcacga cgttgtaaaa cgacgg                                            26


<210> 10
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 10
agtgaacggc aggtatatgt gatgg                                             25


<210> 11
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 11
gtgatgacaa cttcttgtgc gtctggtcag g                                      31


<210> 12
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 12
cctgaccaga cgcacaagaa gttgtcatca c                                      31


<210> 13
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 13
caaactcacc tttggaggtc gatattcagc                                        30


<210> 14
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 14
gctgaatatc gacctccaaa ggtgagtttg                                        30


<210> 15
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 15
gctcaactat tacgtctgcc agatcacgcc atacg                                  35


<210> 16
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 16
cgtatggcgt gatctggcag acgtaatagt tgagc                                  35


<210> 17
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 17
cgtctaccag agcacgctat acgatctacg                                        30


<210> 18
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 18
cgtagatcgt atagcgtgct ctggtagacg                                        30


<210> 19
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 19
atcgatgctg tcgagctttc cactcag                                           27


<210> 20
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 20
ctgagtggaa agctcgacag catcgat                                           27


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 21
gcgcagctgc tggcgatgct gccg                                              24


<210> 22
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 22
cggcagcatc gccagcagct gcgc                                              24


<210> 23
<211> 930
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 23
atgccgattc gtgtgccgga cgagctaccc gccgtcaatt tcttgcgtga agaaaacgtc       60

tttgtgatga caacttcttg tgcgtctggt caggaaattc gtccacttaa ggttctgatc      120

cttaacctga tgccgaagaa gattgaaact gaaaatcagt ttctgcgcct gctttcaaac      180

tcacctttgc aggtcgatat tcagctgttg cgcatcgatt cccgtgaatc gcgcaacacg      240

cccgcagagc atctgaacaa cttctactgt aactttgaag atattcagga tcagaacttt      300

gacggtttga ttgtaactgg tgcgccgctg ggcctggtgg agtttaatga tgtcgcttac      360

tggccgcaga tcaaacaggt gctggagtgg tcgaaagatc acgtcacctc gacgctgttt      420

gtctgctggg cggtacaggc cgcgctcaat atcctctacg gcattcctaa gcaaactcgc      480

accgaaaaac tctctggcgt ttacgagcat catattctcc atcctcatgc gcttctgacg      540

cgtggctttg atgattcatt cctggcaccg cattcgcgct atgctgactt tccggcagcg      600

ttgattcgtg attacaccga tctggaaatt ctggcagaga cggaagaagg ggatgcatat      660

ctgtttgcca gtaaagataa gcgcattgcc tttgtgacgg gccatcccga atatgatgcg      720

caaacgctgg cgcaggaatt tttccgcgat gtggaagccg gactagaccc ggatgtaccg      780

tataactatt tcccgcacaa tgatccgcaa aatacaccgc gagcgagctg gcgtagtcac      840

ggtaatttac tgtttaccaa ctggctcaac tattacgtct accagatcac gccatacgat      900

ctacggcaca tgaatccaac gctggattaa                                       930


<210> 24
<211> 930
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 24
atgccgattc gtgtgccgga cgagctaccc gccgtcaatt tcttgcgtga agaaaacgtc       60

tttgtgatga caacttctcg tgcgtctggt caggaaattc gtccacttaa ggttctgatc      120

cttaacctga tgccgaagaa gattgaaact gaaaatcagt ttctgcgcct gctttcaaac      180

tcacctttgc aggtcgatat tcagctgttg cgcatcgatt cccgtgaatc gcgcaacacg      240

cccgcagagc atctgaacaa cttctactgt aactttgaag atattcagga tcagaacttt      300

gacggtttga ttgtaactgg tgcgccgctg ggcctggtgg agtttaatga tgtcgcttac      360

tggccgcaga tcaaacaggt gctggagtgg tcgaaagatc acgtcacctc gacgctgttt      420

gtctgctggg cggtacaggc cgcgctcaat atcctctacg gcattcctaa gcaaactcgc      480

accgaaaaac tctctggcgt ttacgagcat catattctcc atcctcatgc gcttctgacg      540

cgtggctttg atgattcatt cctggcaccg cattcgcgct atgctgactt tccggcagcg      600

ttgattcgtg attacaccga tctggaaatt ctggcagaga cggaagaagg ggatgcatat      660

ctgtttgcca gtaaagataa gcgcattgcc tttgtgacgg gccatcccga atatgatgcg      720

caaacgctgg cgcaggaatt tttccgcgat gtggaagccg gactagaccc ggatgtaccg      780

tataactatt tcccgcacaa tgatccgcaa aatacaccgc gagcgagctg gcgtagtcac      840

ggtaatttac tgtttaccaa ctggctcaac tattacgtct gccagatcac gccatacgat      900

ctacggcaca tgaatccaac gctggattaa                                       930


<210> 25
<211> 930
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 25
atgccgattc gtgtgccgga cgagctaccc gccgtcaatt tcttgcgtga agaaaacgtc       60

tttgtgatga caacttctcg tgcgtctggt caggaaattc gtccacttaa ggttctgatc      120

cttaacctga tgccgaagaa gattgaaact gaaaatcagt ttctgcgcct gctttcaaac      180

tcacctttgc aggtcgatat tcagctgttg cgcatcgatt cccgtgaatc gcgcaacacg      240

cccgcagagc atctgaacaa cttctactgt aactttgaag atattcagga tcagaacttt      300

gacggtttga ttgtaactgg tgcgccgctg ggcctggtgg agtttaatga tgtcgcttac      360

tggccgcaga tcaaacaggt gctggagtgg tcgaaagatc acgtcacctc gacgctgttt      420

gtctgctggg cggtacaggc cgcgctcaat atcctctacg gcattcctaa gcaaactcgc      480

accgaaaaac tctctggcgt ttacgagcat catattctcc atcctcatgc gcttctgacg      540

cgtggctttg atgattcatt cctggcaccg cattcgcgct atgctgactt tccggcagcg      600

ttgattcgtg attacaccga tctggaaatt ctggcagaga cggaagaagg ggatgcatat      660

ctgtttgcca gtaaagataa gcgcattgcc tttgtgacgg gccatcccga atatgatgcg      720

caaacgctgg cgcaggaatt tttccgcgat gtggaagccg gactagaccc ggatgtaccg      780

tataactatt tcccgcacaa tgatccgcaa aatacaccgc gagcgagctg gcgtagtcac      840

ggtaatttac tgtttaccaa ctggctcaac tattacgtct accagagcac gctatacgat      900

ctacggcaca tgaatccaac gctggattaa                                       930


<210> 26
<211> 930
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 26
atgccgattc gtgtgccgga cgagctaccc gccgtcaatt tcttgcgtga agaaaacgtc       60

tttgtgatga caacttctcg tgcgtctggt caggaaattc gtccacttaa ggttctgatc      120

cttaacctga tgccgaagaa gattgaaact gaaaatcagt ttctgcgcct gctttcaaac      180

tcacctttgg aggtcgatat tcagctgttg cgcatcgatt cccgtgaatc gcgcaacacg      240

cccgcagagc atctgaacaa cttctactgt aactttgaag atattcagga tcagaacttt      300

gacggtttga ttgtaactgg tgcgccgctg ggcctggtgg agtttaatga tgtcgcttac      360

tggccgcaga tcaaacaggt gctggagtgg tcgaaagatc acgtcacctc gacgctgttt      420

gtctgctggg cggtacaggc cgcgctcaat atcctctacg gcattcctaa gcaaactcgc      480

accgaaaaac tctctggcgt ttacgagcat catattctcc atcctcatgc gcttctgacg      540

cgtggctttg atgattcatt cctggcaccg cattcgcgct atgctgactt tccggcagcg      600

ttgattcgtg attacaccga tctggaaatt ctggcagaga cggaagaagg ggatgcatat      660

ctgtttgcca gtaaagataa gcgcattgcc tttgtgacgg gccatcccga atatgatgcg      720

caaacgctgg cgcaggaatt tttccgcgat gtggaagccg gactagaccc ggatgtaccg      780

tataactatt tcccgcacaa tgatccgcaa aatacaccgc gagcgagctg gcgtagtcac      840

ggtaatttac tgtttaccaa ctggctcaac tattacgtct accagatcac gccatacgat      900

ctacggcaca tgaatccaac gctggattaa                                       930


<210> 27
<211> 1155
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 27
atggcaaaac acctttttac gtccgagtcc gtctctgaag ggcatcctga caaaattgct       60

gaccaaattt ctgatgccgt tttagacgcg atcctcgaac aggatccgaa agcacgcgtt      120

gcttgcgaaa cctacgtaaa aaccggcatg gttttagttg gcggcgaaat caccaccagc      180

gcctgggtag acatcgaaga gatcacccgt aacaccgttc gcgaaattgg ctatgtgcat      240

tccgacatgg gctttgacgc taactcctgt gcggttctga gcgctatcgg caaacagtct      300

cctgacatca accagggcgt tgaccgtgcc gatccgctgg aacagggcgc gggtgaccag      360

ggtctgatgt ttggctacgc aactaatgaa accgacgtgc tgatgccagc acctatcacc      420

tatgcacacc gtctggtaca gcgtcaggct gaagtgcgta aaaacggcac tctgccgtgg      480

ctgcgcccgg acgcgaaaag ccaggtgact tttcagtatg acgacggcaa aatcgttggt      540

atcgatgctg tcgagctttc cactcagcac tctgaagaga tcgaccagaa atcgctgcaa      600

gaagcggtaa tggaagagat catcaagcca attctgcccg ctgaatggct gacttctgcc      660

accaaattct tcatcaaccc gaccggtcgt ttcgttatcg gtggcccaat gggtgactgc      720

ggtctgactg gtcgtaaaat tatcgttgat acctacggcg gcatggcgcg tcacggtggc      780

ggtgcattct ctggtaaaga tccatcaaaa gtggaccgtt ccgcagccta cgcagcacgt      840

tatgtcgcga aaaacatcgt tgctgctggc ctggccgatc gttgtgaaat tcaggtttcc      900

tacgcaatcg gcgtggctga accgacctcc atcatggtag aaactttcgg tactgagaaa      960

gtgccttctg aacaactgac cctgctggta cgtgagttct tcgacctgcg cccatacggt     1020

ctgattcaga tgctggatct gctgcacccg atctacaaag aaaccgcagc atacggtcac     1080

tttggtcgtg aacatttccc gtgggaaaaa accgacaaag cgcagctgct gcgcgatgct     1140

gccggtctga agtaa                                                      1155


<210> 28
<211> 1154
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 28
atggcaaaac acctttttac gtccgagtcc gtctctgaag ggcatcctga caaaattgct       60

gaccaaattt ctgatgccgt tttagacgcg atcctcgaac aggatccgaa agcacgcgtt      120

gcttgcgaaa cctacgtaaa aaccggcatg gttttagttg gcggcgaaat caccaccagc      180

gcctgggtag acatcgaaga gatcacccgt aacaccgttc gcgaaattgg ctatgtgcat      240

tccgacatgg gctttgacgc taactcctgt gcggttctga gcgctatcgg caaacagtct      300

cctgacatca accagggcgt tgaccgtgcc gatccgctgg aacagggcgc gggtgaccag      360

ggtctgatgt ttggctacgc aactaatgaa accgacgtgc tgatgccagc acctatcacc      420

tatgcacacc gtctggtaca gcgtcaggct gaagtgcgta aaaacggcac tctgccgtgg      480

ctgcgcccgg acgcgaaaag ccaggtgact tttcagtatg acgacggcaa aatcgttggt      540

atcgatgctg tcgtgctttc cactcagcac tctgaagaga tcgaccagaa atcgctgcaa      600

gaagcggtaa tggaagagat catcaagcca attctgcccg ctgaatggct gacttctgcc      660

accaaattct tcatcaaccc gaccggtcgt ttcgttatcg gtggcccaat gggtgactgc      720

ggtctgactg gtcgtaaaat tatcgttgat acctacggcg gcatggcgcg tcacggtggc      780

ggtgcattct ctggtaaaga tccatcaaaa gtggaccgtt ccgcagccta cgcagcacgt      840

tatgtcgcga aaaacatcgt tgctgctggc ctggccgatc gttgtgaaat tcaggtttcc      900

tacgcaatcg gcgtggctga accgacctcc atcatggtag aaactttcgg tactgagaaa      960

gtgccttctg aacaactgac cctgctggta cgtgagttct tcgacctgcg cccatacggt     1020

ctgattcaga tgctggatct gctgcacccg atctacaaag aaaccgcagc atacggtcac     1080

tttggtcgtg aacatttccc gtgggaaaaa accgacaaag cgcagctgct ggcgatgctg     1140

ccggtctgaa gtaa                                                       1154


<210> 29
<211> 308
<212> PRT
<213> Escherichia coli

<400> 29
Met Pro Ile Arg Val Pro Asp Glu Leu Pro Ala Val Asn Phe Leu Arg 
1               5                   10                  15      


Glu Glu Asn Val Phe Val Met Thr Thr Ser Arg Ala Ser Gly Gln Glu 
            20                  25                  30          


Ile Arg Pro Leu Lys Val Leu Ile Leu Asn Leu Met Pro Lys Lys Ile 
        35                  40                  45              


Glu Thr Glu Asn Gln Phe Leu Arg Leu Leu Ser Asn Ser Pro Leu Gln 
    50                  55                  60                  


Val Asp Ile Gln Leu Leu Arg Ile Asp Ser Arg Glu Ser Arg Asn Thr 
65                  70                  75                  80  


Pro Ala Glu His Leu Asn Asn Phe Tyr Cys Asn Phe Glu Asp Ile Gln 
                85                  90                  95      


Asp Gln Asn Phe Asp Gly Leu Ile Val Thr Gly Ala Pro Leu Gly Leu 
            100                 105                 110         


Val Glu Phe Asn Asp Val Ala Tyr Trp Pro Gln Ile Lys Gln Val Leu 
        115                 120                 125             


Glu Trp Ser Lys Asp His Val Thr Ser Thr Leu Phe Val Cys Trp Ala 
    130                 135                 140                 


Val Gln Ala Ala Leu Asn Ile Leu Tyr Gly Ile Pro Lys Gln Thr Arg 
145                 150                 155                 160 


Thr Glu Lys Leu Ser Gly Val Tyr Glu His His Ile Leu His Pro His 
                165                 170                 175     


Ala Leu Leu Thr Arg Gly Phe Asp Asp Ser Phe Leu Ala His Ser Arg 
            180                 185                 190         


Tyr Ala Asp Phe Pro Ala Ala Leu Ile Arg Asp Tyr Thr Asp Leu Glu 
        195                 200                 205             


Ile Leu Ala Glu Thr Glu Glu Gly Asp Ala Tyr Leu Phe Ala Ser Lys 
    210                 215                 220                 


Asp Lys Arg Ile Ala Phe Val Thr Gly His Pro Glu Tyr Asp Ala Gln 
225                 230                 235                 240 


Thr Leu Ala Gln Glu Phe Phe Arg Asp Val Glu Ala Gly Leu Asp Pro 
                245                 250                 255     


Asp Val Pro Tyr Asn Tyr Phe Pro His Asn Asp Pro Gln Asn Thr Pro 
            260                 265                 270         


Arg Ala Ser Trp Arg Ser His Gly Asn Leu Leu Phe Thr Asn Trp Leu 
        275                 280                 285             


Asn Tyr Tyr Val Tyr Gln Ile Thr Pro Tyr Asp Leu Arg His Met Asn 
    290                 295                 300                 


Pro Thr Leu Asp 
305             


<210> 30
<211> 384
<212> PRT
<213> Escherichia coli

<400> 30
Met Ala Lys His Leu Phe Thr Ser Glu Ser Val Ser Glu Gly His Pro 
1               5                   10                  15      


Asp Lys Ile Ala Asp Gln Ile Ser Asp Ala Val Leu Asp Ala Ile Leu 
            20                  25                  30          


Glu Gln Asp Pro Lys Ala Arg Val Ala Cys Glu Thr Tyr Val Lys Thr 
        35                  40                  45              


Gly Met Val Leu Val Gly Gly Glu Ile Thr Thr Ser Ala Trp Val Asp 
    50                  55                  60                  


Ile Glu Glu Ile Thr Arg Asn Thr Val Arg Glu Ile Gly Tyr Val His 
65                  70                  75                  80  


Ser Asp Met Gly Phe Asp Ala Asn Ser Cys Ala Val Leu Ser Ala Ile 
                85                  90                  95      


Gly Lys Gln Ser Pro Asp Ile Asn Gln Gly Val Asp Arg Ala Asp Pro 
            100                 105                 110         


Leu Glu Gln Gly Ala Gly Asp Gln Gly Leu Met Phe Gly Tyr Ala Thr 
        115                 120                 125             


Asn Glu Thr Asp Val Leu Met Pro Ala Pro Ile Thr Tyr Ala His Arg 
    130                 135                 140                 


Leu Val Gln Arg Gln Ala Glu Val Arg Lys Asn Gly Thr Leu Pro Trp 
145                 150                 155                 160 


Leu Arg Pro Asp Ala Lys Ser Gln Val Thr Phe Gln Tyr Asp Asp Gly 
                165                 170                 175     


Lys Ile Val Gly Ile Asp Ala Val Val Leu Ser Thr Gln His Ser Glu 
            180                 185                 190         


Glu Ile Asp Gln Lys Ser Leu Gln Glu Ala Val Met Glu Glu Ile Ile 
        195                 200                 205             


Lys Pro Ile Leu Pro Ala Glu Trp Leu Thr Ser Ala Thr Lys Phe Phe 
    210                 215                 220                 


Ile Asn Pro Thr Gly Arg Phe Val Ile Gly Gly Pro Met Gly Asp Cys 
225                 230                 235                 240 


Gly Leu Thr Gly Arg Lys Ile Ile Val Asp Thr Tyr Gly Gly Met Ala 
                245                 250                 255     


Arg His Gly Gly Gly Ala Phe Ser Gly Lys Asp Pro Ser Lys Val Asp 
            260                 265                 270         


Arg Ser Ala Ala Tyr Ala Ala Arg Tyr Val Ala Lys Asn Ile Val Ala 
        275                 280                 285             


Ala Gly Leu Ala Asp Arg Cys Glu Ile Gln Val Ser Tyr Ala Ile Gly 
    290                 295                 300                 


Val Ala Glu Pro Thr Ser Ile Met Val Glu Thr Phe Gly Thr Glu Lys 
305                 310                 315                 320 


Val Pro Ser Glu Gln Leu Thr Leu Leu Val Arg Glu Phe Phe Asp Leu 
                325                 330                 335     


Arg Pro Tyr Gly Leu Ile Gln Met Leu Asp Leu Leu His Pro Ile Tyr 
            340                 345                 350         


Lys Glu Thr Ala Ala Tyr Gly His Phe Gly Arg Glu His Phe Pro Trp 
        355                 360                 365             


Glu Lys Thr Asp Lys Ala Gln Leu Leu Arg Asp Ala Ala Gly Leu Lys 
    370                 375                 380                 


<210> 31
<211> 930
<212> DNA
<213> Escherichia coli

<400> 31
atgccgattc gtgtgccgga cgagctaccc gccgtcaatt tcttgcgtga agaaaacgtc       60

tttgtgatga caacttcttg tgcgtctggt caggaaattc gtccacttaa ggttctgatc      120

cttaacctga tgccgaagaa gattgaaact gaaaatcagt ttctgcgcct gctttcaaac      180

tcacctttgc aggtcgatat tcagctgttg cgcatcgatt cccgtgaatc gcgcaacacg      240

cccgcagagc atctgaacaa cttctactgt aactttgaag atattcagga tcagaacttt      300

gacggtttga ttgtaactgg tgcgccgctg ggcctggtgg agtttaatga tgtcgcttac      360

tggccgcaga tcaaacaggt gctggagtgg tcgaaagatc acgtcacctc gacgctgttt      420

gtctgctggg cggtacaggc cgcgctcaat atcctctacg gcattcctaa gcaaactcgc      480

accgaaaaac tctctggcgt ttacgagcat catattctcc atcctcatgc gcttctgacg      540

cgtggctttg atgattcatt cctggcaccg cattcgcgct atgctgactt tccggcagcg      600

ttgattcgtg attacaccga tctggaaatt ctggcagaga cggaagaagg ggatgcatat      660

ctgtttgcca gtaaagataa gcgcattgcc tttgtgacgg gccatcccga atatgatgcg      720

caaacgctgg cgcaggaatt tttccgcgat gtggaagccg gactagaccc ggatgtaccg      780

tataactatt tcccgcacaa tgatccgcaa aatacaccgc gagcgagctg gcgtagtcac      840

ggtaatttac tgtttaccaa ctggctcaac tattacgtct accagatcac gccatacgat      900

ctacggcaca tgaatccaac gctggattaa                                       930


<210> 32
<211> 1155
<212> DNA
<213> Escherichia coli

<400> 32
atggcaaaac acctttttac gtccgagtcc gtctctgaag ggcatcctga caaaattgct       60

gaccaaattt ctgatgccgt tttagacgcg atcctcgaac aggatccgaa agcacgcgtt      120

gcttgcgaaa cctacgtaaa aaccggcatg gttttagttg gcggcgaaat caccaccagc      180

gcctgggtag acatcgaaga gatcacccgt aacaccgttc gcgaaattgg ctatgtgcat      240

tccgacatgg gctttgacgc taactcctgt gcggttctga gcgctatcgg caaacagtct      300

cctgacatca accagggcgt tgaccgtgcc gatccgctgg aacagggcgc gggtgaccag      360

ggtctgatgt ttggctacgc aactaatgaa accgacgtgc tgatgccagc acctatcacc      420

tatgcacacc gtctggtaca gcgtcaggct gaagtgcgta aaaacggcac tctgccgtgg      480

ctgcgcccgg acgcgaaaag ccaggtgact tttcagtatg acgacggcaa aatcgttggt      540

atcgatgctg tcgtgctttc cactcagcac tctgaagaga tcgaccagaa atcgctgcaa      600

gaagcggtaa tggaagagat catcaagcca attctgcccg ctgaatggct gacttctgcc      660

accaaattct tcatcaaccc gaccggtcgt ttcgttatcg gtggcccaat gggtgactgc      720

ggtctgactg gtcgtaaaat tatcgttgat acctacggcg gcatggcgcg tcacggtggc      780

ggtgcattct ctggtaaaga tccatcaaaa gtggaccgtt ccgcagccta cgcagcacgt      840

tatgtcgcga aaaacatcgt tgctgctggc ctggccgatc gttgtgaaat tcaggtttcc      900

tacgcaatcg gcgtggctga accgacctcc atcatggtag aaactttcgg tactgagaaa      960

gtgccttctg aacaactgac cctgctggta cgtgagttct tcgacctgcg cccatacggt     1020

ctgattcaga tgctggatct gctgcacccg atctacaaag aaaccgcagc atacggtcac     1080

tttggtcgtg aacatttccc gtgggaaaaa accgacaaag cgcagctgct gcgcgatgct     1140

gccggtctga agtaa                                                      1155


<210> 33
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 33
gatatccagt tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgca gcgcaagtca ggatattagc aactatttaa actggtatca acagaaacca      120

ggaaaagctc cgaaagtact gatttacttc acctcctctc tccactctgg agtcccttct      180

cgcttctctg gatccggttc tgggacggat ttcactctga ccatcagcag tctgcagcca      240

gaagacttcg caacttatta ctgtcaacag tatagcaccg tgccgtggac gtttggacag      300

ggtaccaagg tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgct tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210> 34
<211> 693
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 34
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggcta cgacttcacg cactacggta tgaactgggt ccgtcaggcc      120

ccgggtaagg gcctggaatg ggttggatgg attaacacct ataccggtga accgacctat      180

gctgcggatt tcaaacgtcg tttcactttt tctttagaca cctccaaaag cacagcatac      240

ctgcagatga acagcctgcg cgctgaggac actgccgtct attactgtgc aaagtacccg      300

tactattatg ggacgagcca ctggtatttc gacgtctggg gtcaaggaac cctggtcacc      360

gtctcctcgg cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt cgacaagaaa      660

gttgagccca aatcttgtga caaaactcac ctc                                   693


<210> 35
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr Gly Met Asn 
1               5                   10                  15      


Trp Val Arg 
            


<210> 36
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Ser Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
1               5                   10      


<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Arg 
1               5                   10                  15  


<210> 38
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr 
1               5                   10                  15      


Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe Lys 
            20                  25          


<210> 39
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp Met Asn 
1               5                   10                  15      


Trp Tyr Gln Gln Lys Pro Gly Lys 
            20                  


<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Gly Leu Glu Trp Val Gly Met Ile Asp Pro Ser Asn Ser Asp Thr Arg 
1               5                   10                  15      


<210> 41
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
1               5                   10      


<210> 42
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Asp Thr Leu Met Ile Ser Arg 
1               5           


<210> 43
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Glu Glu Met Thr Lys 
1               5   


<210> 44
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
1               5                   10                  15      


His Asn His Tyr Thr Gln Lys 
            20              


<210> 45
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg 
        


<210> 46
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 46
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 47
<211> 231
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu 
225                 230     


<210> 48
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 49
<211> 223
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 49
Glu Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Glu Gly Gly Val Asn Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220             


<210> 50
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr 
            20                  25                  30          


Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ala Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210> 51
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asn Ser Asp Thr Arg Phe Asn Pro Asn Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Arg Ser Tyr Val Thr Pro Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             


Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210> 52
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 52
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


