                         SEQUENCE LISTING

<110>  Institute for Cancer Research d/b/a The Research Institute 
       of Fox Chase Cancer Center
 
<120>  Systems and Methods for Diagnosing a Predisposition to Develop 
       Colon Cancer

<130>  185300-3080

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  4479
<212>  DNA
<213>  Homo sapiens

<400>  1
atgccaaatg agggaatccc ccactcaagt caaactcagg agcaagactg tttacagagt       60

caacctgtca gtaataatga agaaatggca atcaagcaag aaagtggtgg tgatggggag      120

gtggaggagt acctctcctt tcgttctgtg ggtgacgggc tgtccacctc tgctgtgggg      180

tgcgcatcag cagctccgag gagagggcca gccctgctgc acatcgaccg acatcagatc      240

caggcagtag agcctagcgc ccaggccctt gagctgcagg gtttgggtgt ggacgtctat      300

gaccaggacg tgctggaaca gggagtgctt cagcaggtgg acaatgccat ccatgaggcc      360

agccgtgcct cccagctcgt tgacgtggag aaggagtatc ggtcggtcct ggatgacctc      420

acgtcatgta cgacatccct aaggcaaatc aataaaatta ttgaacagct tagccctcaa      480

gctgccacca gcagagacat caacaggaaa ctagattctg taaaacgaca gaagtattat      540

aaggaacaac agctaaaaaa gatcactgca aaacaaaagc atctccaggc catccttgga      600

ggagcagagg tgaaaattga actagatcac gccagtctgg aggaggatgc agagccgggg      660

ccatccagtc ttggcagcat gctcatgcct gtccaggaga ctgcctggga agagctcatc      720

cgcactggcc agatgacacc ttttggtacc cagatccctc agaaacagga gaaaaagccc      780

agaaaaatca tgcttaatga agcatcaggc ttcgaaaagt atttggcaga tcaagcaaaa      840

ctgtcttttg aaaggaagaa gcaaggttgt aataaaagag cagctagaaa agctccagcc      900

ccagtcacgc ctccagcccc agtgcaaaat aaaaacaaac caaacaagaa agccagagtt      960

ctgtccaaaa aagaggagcg tttgaaaaag cacatcaaga aactccagaa gagggctttg     1020

cagttccagg ggaaagtggg attgccaaag gcaaggagac cttgggagtc agacatgagg     1080

ccagaggcag agggagactc tgagggtgaa gagtctgagt atttccccac agaggaggag     1140

gaagaggagg aagatgacga ggtggagggg gcagaggcgg acctgtctgg agatggtact     1200

gactatgagc tgaagcctct gcccaagggc gggaaacggc agaagaaagt gccagtgcag     1260

gagattgatg atgacttttt cccaagttct ggggaagaag ctgaagctgc ttctgtagga     1320

gaaggaggag gaggaggtcg gaaagtggga agataccgag atgatggaga tgaagattat     1380

tataagcagc ggttaaggag atggaataaa ctgagactgc aggacaaaga gaaacgtctg     1440

aagctggagg acgattctga ggaaagtgat gctgaatttg acgaaggttt taaagtgcca     1500

ggttttctgt tcaaaaagct ttttaagtac cagcagacag gtgttaggtg gctgtgggaa     1560

ttgcactgcc agcaggcagg aggaattctg ggagatgaaa tgggattggg caagaccatc     1620

cagataattg ccttcttggc aggtctgagc tacagcaaga tcaggactcg tggttcaaat     1680

tacaggtttg aggggttggg tccaactgta attgtctgtc caacaacagt gatgcatcag     1740

tgggtgaagg aatttcacac gtggtggcct ccgttcagag tggcaattct acatgaaacc     1800

ggttcctata cccacaaaaa ggagaaacta attcgagatg ttgctcattg tcatggaatt     1860

ttgatcacat cttactccta cattcgattg atgcaggatg acattagcag gtatgactgg     1920

cactatgtga tcttggacga aggacacaaa attcgaaatc caaatgctgc tgtcaccctt     1980

gcttgcaaac agtttcgcac ccctcatcgg atcattctgt ctggctcacc gatgcaaaat     2040

aacctccgag agctgtggtc gctctttgac ttcatcttcc cgggaaagtt aggcacgttg     2100

cctgtgttta tggagcagtt ctccgtcccc atcaccatgg ggggatattc aaatgcttcc     2160

ccagtacagg tcaaaactgc ttacaagtgt gcatgtgtct tacgagatac cataaatcca     2220

tacctactgc ggagaatgaa gtcagatgtc aagatgagcc tttctttgcc agataaaaat     2280

gaacaggtct tattttgccg tcttacagat gagcagcata aagtctacca aaatttcgtt     2340

gattccaaag aagtttacag gattctcaat ggagagatgc agattttctc cggacttata     2400

gccctaagaa aaatttgcaa ccaccctgat ctcttttctg gaggtcccaa gaatctcaaa     2460

ggtcttcctg atgatgaact agaagaagat cagtttgggt actggaaacg ttctgggaaa     2520

atgattgttg ttgagtcttt gttgaaaata tggcacaagc agggtcagcg agtattgctg     2580

ttttctcagt caaggcagat gctggacata cttgaagtat tccttagagc ccaaaagtat     2640

acctatctca agatggatgg taccactaca atagcttcaa gacagccact gattacgaga     2700

tacaatgagg acacatccat atttgtgttt cttctgacca cgcgggtggg cggcttaggt     2760

gtcaacctga cgggggcaaa cagagttgtc atctatgacc cagactggaa cccaagcacg     2820

gacacgcagg cccgggagcg agcatggaga ataggccaga agaagcaagt gactgtgtac     2880

aggctcctga ctgcgggcac cattgaagaa aagatctacc accgacaaat cttcaagcag     2940

tttttgacaa atagagtgct aaaagaccca aaacaaaggc ggtttttcaa atccaatgat     3000

ctctatgagc tatttactct gactagtcct gatgcatccc agagcactga aacaagtgca     3060

atttttgcag gaactggatc agatgttcag acacccaaat gccatctaaa aagaaggatt     3120

caaccagcct ttggagcaga ccatgatgtt ccaaaacgca agaagttccc tgcttctaac     3180

atatctgtaa atgatgccac atcatctgaa gagaaatctg aggctaaagg agctgaagta     3240

aatgcagtaa cttctaatcg aagtgatcct ttgaaagatg accctcacat gagtagtaat     3300

gtaactagca atgataggct tggagaagag acaaatgcag tatctggacc agaagagttg     3360

tcagtgatta gtggaaatgg ggaatgttca aattcttcag gaacaggcaa aacttctatg     3420

ccatctggtg atgaaagcat tgatgaaaag ttaggtcttt cttacaaaag agaaagaccc     3480

agccaggctc aaacagaagc tttttgggag aataaacaaa tggaaaataa tttttataag     3540

cacaagtcaa aaacaaaaca tcatagtgtg gcagaagaag agaccctgga gaaacatctg     3600

agaccaaagc aaaagcctaa gaactctaag cattgcagag acgccaagtt tgaaggaact     3660

cgaattccac acctggtgaa gaaaaggcgt taccagaagc aagacagtga aaacaagagt     3720

gaggccaagg aacagagcaa tgacgattat gttttggaaa agcttttcaa aaaatcagtt     3780

ggcgtgcaca gtgtcatgaa gcacgatgcc atcatggatg gagccagccc agattatgta     3840

ctggtggagg cagaagccaa ccgagtggcc caggatgccc tgaaagcact gaggctctct     3900

cgtcagcggt gtctgggagc agtgtctggt gttcccacct ggactggcca cagggggatt     3960

tctggtgcac cagcaggaaa aaagagtaga tttggtaaga aaaggaattc taacttctct     4020

gtgcagcatc cttcatcaac atctccaaca gagaagtgcc aggatggcat catgaaaaag     4080

gagggaaaag ataatgtccc tgagcatttt agtggaagag cagaagatgc agactcttca     4140

tccgggcccc tcgcttcctc ctcactcttg gctaaaatga gagctagaaa ccacctgatt     4200

ctgccagagc gtttagaaag tgaaagcggg cacctgcagg aagcttctgc cctgctgccc     4260

accacagaac acgatgacct tctggtggag atgagaaact tcatcgcttt ccaggcccac     4320

actgatggcc aggccagcac cagggagata ctgcaggagt ttgaatccaa gttatctgca     4380

tcacagtctt gtgtcttccg agaactattg agaaatctgt gcactttcca tagaacttct     4440

ggtggtgaag gaatttggaa actcaagcca gaatactgc                            4479


<210>  2
<211>  4479
<212>  DNA
<213>  Homo sapiens

<400>  2
atgccaaatg agggaatccc ccactcaagt caaactcagg agcaagactg tttacagagt       60

caacctgtca gtaataatga agaaatggca atcaagcaag aaagtggtgg tgatggggag      120

gtggaggagt acctctcctt tcgttctgtg ggtgacgggc tgtccacctc tgctgtgggg      180

tgcgcatcag cagctccgag gagagggcca gccctgctgc acatcgaccg acatcagatc      240

caggcagtag agcctagcgc ccaggccctt gagctgcagg gtttgggtgt ggacgtctat      300

gaccaggacg tgctggaaca gggagtgctt cagcaggtgg acaatgccat ccatgaggcc      360

agccgtgcct cccagctcgt tgacgtggag aaggagtatc ggtcggtcct ggatgacctc      420

acgtcatgta cgacatccct aaggcaaatc aataaaatta ttgaacagct tagccctcaa      480

gctgccacca gcagagacat caacaggaaa ctagattctg taaaacgaca gaagtataat      540

aaggaacaac agctaaaaaa gatcactgca aaacaaaagc atctccaggc catccttgga      600

ggagcagagg tgaaaattga actagatcac gccagtctgg aggaggatgc agagccgggg      660

ccatccagtc ttggcagcat gctcatgcct gtccaggaga ctgcctggga agagctcatc      720

cgcactggcc agatgacacc ttttggtacc cagatccctc agaaacagga gaaaaagccc      780

agaaaaatca tgcttaatga agcatcaggc ttcgaaaagt atttggcaga tcaagcaaaa      840

ctgtcttttg aaaggaagaa gcaaggttgt aataaaagag cagctagaaa agctccagcc      900

ccagtcacgc ctccagcccc agtgcaaaat aaaaacaaac caaacaagaa agccagagtt      960

ctgtccaaaa aagaggagcg tttgaaaaag cacatcaaga aactccagaa gagggctttg     1020

cagttccagg ggaaagtggg attgccaaag gcaaggagac cttgggagtc agacatgagg     1080

ccagaggcag agggagactc tgagggtgaa gagtctgagt atttccccac agaggaggag     1140

gaagaggagg aagatgacga ggtggagggg gcagaggcgg acctgtctgg agatggtact     1200

gactatgagc tgaagcctct gcccaagggc gggaaacggc agaagaaagt gccagtgcag     1260

gagattgatg atgacttttt cccaagttct ggggaagaag ctgaagctgc ttctgtagga     1320

gaaggaggag gaggaggtcg gaaagtggga agataccgag atgatggaga tgaagattat     1380

tataagcagc ggttaaggag atggaataaa ctgagactgc aggacaaaga gaaacgtctg     1440

aagctggagg acgattctga ggaaagtgat gctgaatttg acgaaggttt taaagtgcca     1500

ggttttctgt tcaaaaagct ttttaagtac cagcagacag gtgttaggtg gctgtgggaa     1560

ttgcactgcc agcaggcagg aggaattctg ggagatgaaa tgggattggg caagaccatc     1620

cagataattg ccttcttggc aggtctgagc tacagcaaga tcaggactcg tggttcaaat     1680

tacaggtttg aggggttggg tccaactgta attgtctgtc caacaacagt gatgcatcag     1740

tgggtgaagg aatttcacac gtggtggcct ccgttcagag tggcaattct acatgaaacc     1800

ggttcctata cccacaaaaa ggagaaacta attcgagatg ttgctcattg tcatggaatt     1860

ttgatcacat cttactccta cattcgattg atgcaggatg acattagcag gtatgactgg     1920

cactatgtga tcttggacga aggacacaaa attcgaaatc caaatgctgc tgtcaccctt     1980

gcttgcaaac agtttcgcac ccctcatcgg atcattctgt ctggctcacc gatgcaaaat     2040

aacctccgag agctgtggtc gctctttgac ttcatcttcc cgggaaagtt aggcacgttg     2100

cctgtgttta tggagcagtt ctccgtcccc atcaccatgg ggggatattc aaatgcttcc     2160

ccagtacagg tcaaaactgc ttacaagtgt gcatgtgtct tacgagatac cataaatcca     2220

tacctactgc ggagaatgaa gtcagatgtc aagatgagcc tttctttgcc agataaaaat     2280

gaacaggtct tattttgccg tcttacagat gagcagcata aagtctacca aaatttcgtt     2340

gattccaaag aagtttacag gattctcaat ggagagatgc agattttctc cggacttata     2400

gccctaagaa aaatttgcaa ccaccctgat ctcttttctg gaggtcccaa gaatctcaaa     2460

ggtcttcctg atgatgaact agaagaagat cagtttgggt actggaaacg ttctgggaaa     2520

atgattgttg ttgagtcttt gttgaaaata tggcacaagc agggtcagcg agtattgctg     2580

ttttctcagt caaggcagat gctggacata cttgaagtat tccttagagc ccaaaagtat     2640

acctatctca agatggatgg taccactaca atagcttcaa gacagccact gattacgaga     2700

tacaatgagg acacatccat atttgtgttt cttctgacca cgcgggtggg cggcttaggt     2760

gtcaacctga cgggggcaaa cagagttgtc atctatgacc cagactggaa cccaagcacg     2820

gacacgcagg cccgggagcg agcatggaga ataggccaga agaagcaagt gactgtgtac     2880

aggctcctga ctgcgggcac cattgaagaa aagatctacc accgacaaat cttcaagcag     2940

tttttgacaa atagagtgct aaaagaccca aaacaaaggc ggtttttcaa atccaatgat     3000

ctctatgagc tatttactct gactagtcct gatgcatccc agagcactga aacaagtgca     3060

atttttgcag gaactggatc agatgttcag acacccaaat gccatctaaa aagaaggatt     3120

caaccagcct ttggagcaga ccatgatgtt ccaaaacgca agaagttccc tgcttctaac     3180

atatctgtaa atgatgccac atcatctgaa gagaaatctg aggctaaagg agctgaagta     3240

aatgcagtaa cttctaatcg aagtgatcct ttgaaagatg accctcacat gagtagtaat     3300

gtaactagca atgataggct tggagaagag acaaatgcag tatctggacc agaagagttg     3360

tcagtgatta gtggaaatgg ggaatgttca aattcttcag gaacaggcaa aacttctatg     3420

ccatctggtg atgaaagcat tgatgaaaag ttaggtcttt cttacaaaag agaaagaccc     3480

agccaggctc aaacagaagc tttttgggag aataaacaaa tggaaaataa tttttataag     3540

cacaagtcaa aaacaaaaca tcatagtgtg gcagaagaag agaccctgga gaaacatctg     3600

agaccaaagc aaaagcctaa gaactctaag cattgcagag acgccaagtt tgaaggaact     3660

cgaattccac acctggtgaa gaaaaggcgt taccagaagc aagacagtga aaacaagagt     3720

gaggccaagg aacagagcaa tgacgattat gttttggaaa agcttttcaa aaaatcagtt     3780

ggcgtgcaca gtgtcatgaa gcacgatgcc atcatggatg gagccagccc agattatgta     3840

ctggtggagg cagaagccaa ccgagtggcc caggatgccc tgaaagcact gaggctctct     3900

cgtcagcggt gtctgggagc agtgtctggt gttcccacct ggactggcca cagggggatt     3960

tctggtgcac cagcaggaaa aaagagtaga tttggtaaga aaaggaattc taacttctct     4020

gtgcagcatc cttcatcaac atctccaaca gagaagtgcc aggatggcat catgaaaaag     4080

gagggaaaag ataatgtccc tgagcatttt agtggaagag cagaagatgc agactcttca     4140

tccgggcccc tcgcttcctc ctcactcttg gctaaaatga gagctagaaa ccacctgatt     4200

ctgccagagc gtttagaaag tgaaagcggg cacctgcagg aagcttctgc cctgctgccc     4260

accacagaac acgatgacct tctggtggag atgagaaact tcatcgcttt ccaggcccac     4320

actgatggcc aggccagcac cagggagata ctgcaggagt ttgaatccaa gttatctgca     4380

tcacagtctt gtgtcttccg agaactattg agaaatctgt gcactttcca tagaacttct     4440

ggtggtgaag gaatttggaa actcaagcca gaatactgc                            4479


<210>  3
<211>  7006
<212>  DNA
<213>  Homo sapiens

<400>  3
agcagaagtc ggagtcgctg ttgggggcgg tgtctatggt tgagctgagg gcgcaggcgc       60

cacggcccgt cgagctgggt tccaaggcgg ctggcggcgg tagcgtctct gtttccttgt      120

gggcgctcgc gcggccctgg gtagtctgta gagaatgcca aatgagggaa tcccccactc      180

aagtcaaact caggagcaag actgtttaca gagtcaacct gtcagtaata atgaagaaat      240

ggcaatcaag caagaaagtg gtggtgatgg ggaggtggag gagtacctct cctttcgttc      300

tgtgggtgac gggctgtcca cctctgctgt ggggtgcgca tcagcagctc cgaggagagg      360

gccagccctg ctgcacatcg accgacatca gatccaggca gtagagccta gcgcccaggc      420

ccttgagctg cagggtttgg gtgtggacgt ctatgaccag gacgtgctgg aacagggagt      480

gcttcagcag gtggacaatg ccatccatga ggccagccgt gcctcccagc tcgttgacgt      540

ggagaaggag tatcggtcgg tcctggatga cctcacgtca tgtacgacat ccctaaggca      600

aatcaataaa attattgaac agcttagccc tcaagctgcc accagcagag acatcaacag      660

gaaactagat tctgtaaaac gacagaagta taataaggaa caacagctaa aaaagatcac      720

tgcaaaacaa aagcatctcc aggccatcct tggaggagca gaggtgaaaa ttgaactaga      780

tcacgccagt ctggaggagg atgcagagcc ggggccatcc agtcttggca gcatgctcat      840

gcctgtccag gagactgcct gggaagagct catccgcact ggccagatga caccttttgg      900

tacccagatc cctcagaaac aggagaaaaa gcccagaaaa atcatgctta atgaagcatc      960

aggcttcgaa aagtatttgg cagatcaagc aaaactgtct tttgaaagga agaagcaagg     1020

ttgtaataaa agagcagcta gaaaagctcc agccccagtc acgcctccag ccccagtgca     1080

aaataaaaac aaaccaaaca agaaagccag agttctgtcc aaaaaagagg agcgtttgaa     1140

aaagcacatc aagaaactcc agaagagggc tttgcagttc caggggaaag tgggattgcc     1200

aaaggcaagg agaccttggg agtcagacat gaggccagag gcagagggag actctgaggg     1260

tgaagagtct gagtatttcc ccacagagga ggaggaagag gaggaagatg acgaggtgga     1320

gggggcagag gcggacctgt ctggagatgg tactgactat gagctgaagc ctctgcccaa     1380

gggcgggaaa cggcagaaga aagtgccagt gcaggagatt gatgatgact ttttcccaag     1440

ttctggggaa gaagctgaag ctgcttctgt aggagaagga ggaggaggag gtcggaaagt     1500

gggaagatac cgagatgatg gagatgaaga ttattataag cagcggttaa ggagatggaa     1560

taaactgaga ctgcaggaca aagagaaacg tctgaagctg gaggacgatt ctgaggaaag     1620

tgatgctgaa tttgacgaag gttttaaagt gccaggtttt ctgttcaaaa agctttttaa     1680

gtaccagcag acaggtgtta ggtggctgtg ggaattgcac tgccagcagg caggaggaat     1740

tctgggagat gaaatgggat tgggcaagac catccagata attgccttct tggcaggtct     1800

gagctacagc aagatcagga ctcgtggttc aaattacagg tttgaggggt tgggtccaac     1860

tgtaattgtc tgtccaacaa cagtgatgca tcagtgggtg aaggaatttc acacgtggtg     1920

gcctccgttc agagtggcaa ttctacatga aaccggttcc tatacccaca aaaaggagaa     1980

actaattcga gatgttgctc attgtcatgg aattttgatc acatcttact cctacattcg     2040

attgatgcag gatgacatta gcaggtatga ctggcactat gtgatcttgg acgaaggaca     2100

caaaattcga aatccaaatg ctgctgtcac ccttgcttgc aaacagtttc gcacccctca     2160

tcggatcatt ctgtctggct caccgatgca aaataacctc cgagagctgt ggtcgctctt     2220

tgacttcatc ttcccgggaa agttaggcac gttgcctgtg tttatggagc agttctccgt     2280

ccccatcacc atggggggat attcaaatgc ttccccagta caggtcaaaa ctgcttacaa     2340

gtgtgcatgt gtcttacgag ataccataaa tccataccta ctgcggagaa tgaagtcaga     2400

tgtcaagatg agcctttctt tgccagataa aaatgaacag gtcttatttt gccgtcttac     2460

agatgagcag cataaagtct accaaaattt cgttgattcc aaagaagttt acaggattct     2520

caatggagag atgcagattt tctccggact tatagcccta agaaaaattt gcaaccaccc     2580

tgatctcttt tctggaggtc ccaagaatct caaaggtctt cctgatgatg aactagaaga     2640

agatcagttt gggtactgga aacgttctgg gaaaatgatt gttgttgagt ctttgttgaa     2700

aatatggcac aagcagggtc agcgagtatt gctgttttct cagtcaaggc agatgctgga     2760

catacttgaa gtattcctta gagcccaaaa gtatacctat ctcaagatgg atggtaccac     2820

tacaatagct tcaagacagc cactgattac gagatacaat gaggacacat ccatatttgt     2880

gtttcttctg accacgcggg tgggcggctt aggtgtcaac ctgacggggg caaacagagt     2940

tgtcatctat gacccagact ggaacccaag cacggacacg caggcccggg agcgagcatg     3000

gagaataggc cagaagaagc aagtgactgt gtacaggctc ctgactgcgg gcaccattga     3060

agaaaagatc taccaccgac aaatcttcaa gcagtttttg acaaatagag tgctaaaaga     3120

cccaaaacaa aggcggtttt tcaaatccaa tgatctctat gagctattta ctctgactag     3180

tcctgatgca tcccagagca ctgaaacaag tgcaattttt gcaggaactg gatcagatgt     3240

tcagacaccc aaatgccatc taaaaagaag gattcaacca gcctttggag cagaccatga     3300

tgttccaaaa cgcaagaagt tccctgcttc taacatatct gtaaatgatg ccacatcatc     3360

tgaagagaaa tctgaggcta aaggagctga agtaaatgca gtaacttcta atcgaagtga     3420

tcctttgaaa gatgaccctc acatgagtag taatgtaact agcaatgata ggcttggaga     3480

agagacaaat gcagtatctg gaccagaaga gttgtcagtg attagtggaa atggggaatg     3540

ttcaaattct tcaggaacag gcaaaacttc tatgccatct ggtgatgaaa gcattgatga     3600

aaagttaggt ctttcttaca aaagagaaag acccagccag gctcaaacag aagctttttg     3660

ggagaataaa caaatggaaa ataattttta taagcacaag tcaaaaacaa aacatcatag     3720

tgtggcagaa gaagagaccc tggagaaaca tctgagacca aagcaaaagc ctaagaactc     3780

taagcattgc agagacgcca agtttgaagg aactcgaatt ccacacctgg tgaagaaaag     3840

gcgttaccag aagcaagaca gtgaaaacaa gagtgaggcc aaggaacaga gcaatgacga     3900

ttatgttttg gaaaagcttt tcaaaaaatc agttggcgtg cacagtgtca tgaagcacga     3960

tgccatcatg gatggagcca gcccagatta tgtactggtg gaggcagaag ccaaccgagt     4020

ggcccaggat gccctgaaag cactgaggct ctctcgtcag cggtgtctgg gagcagtgtc     4080

tggtgttccc acctggactg gccacagggg gatttctggt gcaccagcag gaaaaaagag     4140

tagatttggt aagaaaagga attctaactt ctctgtgcag catccttcat caacatctcc     4200

aacagagaag tgccaggatg gcatcatgaa aaaggaggga aaagataatg tccctgagca     4260

ttttagtgga agagcagaag atgcagactc ttcatccggg cccctcgctt cctcctcact     4320

cttggctaaa atgagagcta gaaaccacct gattctgcca gagcgtttag aaagtgaaag     4380

cgggcacctg caggaagctt ctgccctgct gcccaccaca gaacacgatg accttctggt     4440

ggagatgaga aacttcatcg ctttccaggc ccacactgat ggccaggcca gcaccaggga     4500

gatactgcag gagtttgaat ccaagttatc tgcatcacag tcttgtgtct tccgagaact     4560

attgagaaat ctgtgcactt tccatagaac ttctggtggt gaaggaattt ggaaactcaa     4620

gccagaatac tgctaaacaa cattgcttcc taaactttca agtccctttt tctaacgggc     4680

atttctgatt attaatttat tattaataat catgtttgtc aatggaagtt ggctgcactt     4740

gatgtttgtt tgcatgatgt ctacctcaga attaaaactt taaggaagaa gaaactcttc     4800

tctgaaagtt aaaagtttta ataatgctag ctaaaggaga aaatacttgg attgattttt     4860

ttttttttgg caatctaatt atattgtaaa tcaggtacct aacagttact ccttggagca     4920

catttgttcc tttacccaaa agatgctgtc agggagcaca gttagaagtt tgcagaacag     4980

aaatctcaat attttttttt attggtgcta aaaacaggtc ttacattcag tcagacctgt     5040

tcaataagtt catcaatatc tgataacagc attattttga tgcttaaact ttaaacattt     5100

atatttacca tttgccaccc acaaaggtca ggtttgttat ttgttgtttg ataattatat     5160

taattttctt ggaaagatcc tcttttcaag gtactggtaa attggtgagt atttttatta     5220

gtaaagcatg aaatagtatg gtaataaatg ataagacatg tatttgtgga aagctgtagg     5280

gtattcagtt taccctggct ttcctttaag cagagggcat ctttttctct cctacagtca     5340

caaaatgtgt tatcattaaa aaaaatcaaa ttaaagccaa aagtaggtac ataaaaacca     5400

cacacatgca tgcacacaaa catcactgca gcccacagca gacccagccg ttgttaccat     5460

gaagtgacac cactccaggc ctctcttgtc tgcaggctgg caggctgtct tctctccagt     5520

tgccttcgtc ttgcgcctgc ctttgcattc cttgcgacgg gctttcttgt ttctgcggtt     5580

tggattccag ccaaggctgt ttgtatctca ctactgttta tgtgtttgtg gttctgtgat     5640

ggtgttgctt tgatcctcag tttattttct tacccatgtt tttcttgttt ccttctcagg     5700

atgattttat catctcatct ttgaagtgtt gttttccgaa attcatcgta ttcctgaaat     5760

ttcttcttag ctgtcttagt gcagtttgtt tcttggattt gtattctctg gcatgctctt     5820

ttcctctctc tcatttttct gtagtatgcc tgccctccta ccctgctatt tctttacatc     5880

tctctcatgc ttaacatgga tagctgtgtc cagatcttct gtctgctcat ccatgtgact     5940

cagagaggag ggttctgggc aggggggcct tgccggactg catgagagga catgagtttt     6000

gctttctctg ctctaatatt ttgcttaagc caagaatcct tttcttagag atgttctata     6060

tgattcctgt caggattttc tagttttttt tggattatag cttgttcatt tcttttgttt     6120

ttagtttggt ttatatataa tgagggaaga agatgattac attatttttg tcactttgcc     6180

atcattgttt agaagtcata gaaagaattt ttaaataggc caataagtct taaacttgag     6240

tacttggctt agaagaaagt caaaactcct tcctttttga ctaagtggtt tgtttctggg     6300

gagctcttaa tttctatttt tataatcatt agcctataag gaaattgtgt cttccttgtt     6360

ctcagggtga tctgctgacc ttgttcactc atgaagcatt tgggtatcat acttatagtg     6420

tctgaaacat aaactgtatt gagctagaca aggtatagcc tcctcttcaa gtagcaaata     6480

ctatcaaaag ctataatgca gtaggagcaa ggtggtcctt gttccagttt ttgtctcagt     6540

tctgctgctg atgtaccatg atcttgggaa ggtggtgtct cagtgtggag atctgacaca     6600

ttgttaccgt gcctcctggc tggagggact tggagaacaa tgcagttaag tagaatggtt     6660

ttaacaatac agagaaattt attcatttag ataaaaatct gatttttaga actttaaaag     6720

ctttgtacag tgtaaataga tttaatgtat ttaacatgct ttatcagcac aaataaagga     6780

ttttaaaatt ttgtcaaaaa attaaatgtt aatactatca ccattaaaaa tgttcaagca     6840

atagtctgcc tccccacccc cacaccatct tgcacctgtt ccacagctaa gtacagccct     6900

aggtttggtg tgtattctcc atgcatttag agaatcacat gacacagact gctgctataa     6960

tgtcattttc ccattcttcc tttactaata aaatttttga gtttta                    7006


<210>  4
<211>  1493
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Asn Glu Gly Ile Pro His Ser Ser Gln Thr Gln Glu Gln Asp 
1               5                   10                  15      


Cys Leu Gln Ser Gln Pro Val Ser Asn Asn Glu Glu Met Ala Ile Lys 
            20                  25                  30          


Gln Glu Ser Gly Gly Asp Gly Glu Val Glu Glu Tyr Leu Ser Phe Arg 
        35                  40                  45              


Ser Val Gly Asp Gly Leu Ser Thr Ser Ala Val Gly Cys Ala Ser Ala 
    50                  55                  60                  


Ala Pro Arg Arg Gly Pro Ala Leu Leu His Ile Asp Arg His Gln Ile 
65                  70                  75                  80  


Gln Ala Val Glu Pro Ser Ala Gln Ala Leu Glu Leu Gln Gly Leu Gly 
                85                  90                  95      


Val Asp Val Tyr Asp Gln Asp Val Leu Glu Gln Gly Val Leu Gln Gln 
            100                 105                 110         


Val Asp Asn Ala Ile His Glu Ala Ser Arg Ala Ser Gln Leu Val Asp 
        115                 120                 125             


Val Glu Lys Glu Tyr Arg Ser Val Leu Asp Asp Leu Thr Ser Cys Thr 
    130                 135                 140                 


Thr Ser Leu Arg Gln Ile Asn Lys Ile Ile Glu Gln Leu Ser Pro Gln 
145                 150                 155                 160 


Ala Ala Thr Ser Arg Asp Ile Asn Arg Lys Leu Asp Ser Val Lys Arg 
                165                 170                 175     


Gln Lys Tyr Tyr Lys Glu Gln Gln Leu Lys Lys Ile Thr Ala Lys Gln 
            180                 185                 190         


Lys His Leu Gln Ala Ile Leu Gly Gly Ala Glu Val Lys Ile Glu Leu 
        195                 200                 205             


Asp His Ala Ser Leu Glu Glu Asp Ala Glu Pro Gly Pro Ser Ser Leu 
    210                 215                 220                 


Gly Ser Met Leu Met Pro Val Gln Glu Thr Ala Trp Glu Glu Leu Ile 
225                 230                 235                 240 


Arg Thr Gly Gln Met Thr Pro Phe Gly Thr Gln Ile Pro Gln Lys Gln 
                245                 250                 255     


Glu Lys Lys Pro Arg Lys Ile Met Leu Asn Glu Ala Ser Gly Phe Glu 
            260                 265                 270         


Lys Tyr Leu Ala Asp Gln Ala Lys Leu Ser Phe Glu Arg Lys Lys Gln 
        275                 280                 285             


Gly Cys Asn Lys Arg Ala Ala Arg Lys Ala Pro Ala Pro Val Thr Pro 
    290                 295                 300                 


Pro Ala Pro Val Gln Asn Lys Asn Lys Pro Asn Lys Lys Ala Arg Val 
305                 310                 315                 320 


Leu Ser Lys Lys Glu Glu Arg Leu Lys Lys His Ile Lys Lys Leu Gln 
                325                 330                 335     


Lys Arg Ala Leu Gln Phe Gln Gly Lys Val Gly Leu Pro Lys Ala Arg 
            340                 345                 350         


Arg Pro Trp Glu Ser Asp Met Arg Pro Glu Ala Glu Gly Asp Ser Glu 
        355                 360                 365             


Gly Glu Glu Ser Glu Tyr Phe Pro Thr Glu Glu Glu Glu Glu Glu Glu 
    370                 375                 380                 


Asp Asp Glu Val Glu Gly Ala Glu Ala Asp Leu Ser Gly Asp Gly Thr 
385                 390                 395                 400 


Asp Tyr Glu Leu Lys Pro Leu Pro Lys Gly Gly Lys Arg Gln Lys Lys 
                405                 410                 415     


Val Pro Val Gln Glu Ile Asp Asp Asp Phe Phe Pro Ser Ser Gly Glu 
            420                 425                 430         


Glu Ala Glu Ala Ala Ser Val Gly Glu Gly Gly Gly Gly Gly Arg Lys 
        435                 440                 445             


Val Gly Arg Tyr Arg Asp Asp Gly Asp Glu Asp Tyr Tyr Lys Gln Arg 
    450                 455                 460                 


Leu Arg Arg Trp Asn Lys Leu Arg Leu Gln Asp Lys Glu Lys Arg Leu 
465                 470                 475                 480 


Lys Leu Glu Asp Asp Ser Glu Glu Ser Asp Ala Glu Phe Asp Glu Gly 
                485                 490                 495     


Phe Lys Val Pro Gly Phe Leu Phe Lys Lys Leu Phe Lys Tyr Gln Gln 
            500                 505                 510         


Thr Gly Val Arg Trp Leu Trp Glu Leu His Cys Gln Gln Ala Gly Gly 
        515                 520                 525             


Ile Leu Gly Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ile Ile Ala 
    530                 535                 540                 


Phe Leu Ala Gly Leu Ser Tyr Ser Lys Ile Arg Thr Arg Gly Ser Asn 
545                 550                 555                 560 


Tyr Arg Phe Glu Gly Leu Gly Pro Thr Val Ile Val Cys Pro Thr Thr 
                565                 570                 575     


Val Met His Gln Trp Val Lys Glu Phe His Thr Trp Trp Pro Pro Phe 
            580                 585                 590         


Arg Val Ala Ile Leu His Glu Thr Gly Ser Tyr Thr His Lys Lys Glu 
        595                 600                 605             


Lys Leu Ile Arg Asp Val Ala His Cys His Gly Ile Leu Ile Thr Ser 
    610                 615                 620                 


Tyr Ser Tyr Ile Arg Leu Met Gln Asp Asp Ile Ser Arg Tyr Asp Trp 
625                 630                 635                 640 


His Tyr Val Ile Leu Asp Glu Gly His Lys Ile Arg Asn Pro Asn Ala 
                645                 650                 655     


Ala Val Thr Leu Ala Cys Lys Gln Phe Arg Thr Pro His Arg Ile Ile 
            660                 665                 670         


Leu Ser Gly Ser Pro Met Gln Asn Asn Leu Arg Glu Leu Trp Ser Leu 
        675                 680                 685             


Phe Asp Phe Ile Phe Pro Gly Lys Leu Gly Thr Leu Pro Val Phe Met 
    690                 695                 700                 


Glu Gln Phe Ser Val Pro Ile Thr Met Gly Gly Tyr Ser Asn Ala Ser 
705                 710                 715                 720 


Pro Val Gln Val Lys Thr Ala Tyr Lys Cys Ala Cys Val Leu Arg Asp 
                725                 730                 735     


Thr Ile Asn Pro Tyr Leu Leu Arg Arg Met Lys Ser Asp Val Lys Met 
            740                 745                 750         


Ser Leu Ser Leu Pro Asp Lys Asn Glu Gln Val Leu Phe Cys Arg Leu 
        755                 760                 765             


Thr Asp Glu Gln His Lys Val Tyr Gln Asn Phe Val Asp Ser Lys Glu 
    770                 775                 780                 


Val Tyr Arg Ile Leu Asn Gly Glu Met Gln Ile Phe Ser Gly Leu Ile 
785                 790                 795                 800 


Ala Leu Arg Lys Ile Cys Asn His Pro Asp Leu Phe Ser Gly Gly Pro 
                805                 810                 815     


Lys Asn Leu Lys Gly Leu Pro Asp Asp Glu Leu Glu Glu Asp Gln Phe 
            820                 825                 830         


Gly Tyr Trp Lys Arg Ser Gly Lys Met Ile Val Val Glu Ser Leu Leu 
        835                 840                 845             


Lys Ile Trp His Lys Gln Gly Gln Arg Val Leu Leu Phe Ser Gln Ser 
    850                 855                 860                 


Arg Gln Met Leu Asp Ile Leu Glu Val Phe Leu Arg Ala Gln Lys Tyr 
865                 870                 875                 880 


Thr Tyr Leu Lys Met Asp Gly Thr Thr Thr Ile Ala Ser Arg Gln Pro 
                885                 890                 895     


Leu Ile Thr Arg Tyr Asn Glu Asp Thr Ser Ile Phe Val Phe Leu Leu 
            900                 905                 910         


Thr Thr Arg Val Gly Gly Leu Gly Val Asn Leu Thr Gly Ala Asn Arg 
        915                 920                 925             


Val Val Ile Tyr Asp Pro Asp Trp Asn Pro Ser Thr Asp Thr Gln Ala 
    930                 935                 940                 


Arg Glu Arg Ala Trp Arg Ile Gly Gln Lys Lys Gln Val Thr Val Tyr 
945                 950                 955                 960 


Arg Leu Leu Thr Ala Gly Thr Ile Glu Glu Lys Ile Tyr His Arg Gln 
                965                 970                 975     


Ile Phe Lys Gln Phe Leu Thr Asn Arg Val Leu Lys Asp Pro Lys Gln 
            980                 985                 990         


Arg Arg Phe Phe Lys Ser Asn Asp  Leu Tyr Glu Leu Phe  Thr Leu Thr 
        995                 1000                 1005             


Ser Pro  Asp Ala Ser Gln Ser  Thr Glu Thr Ser Ala  Ile Phe Ala 
    1010                 1015                 1020             


Gly Thr  Gly Ser Asp Val Gln  Thr Pro Lys Cys His  Leu Lys Arg 
    1025                 1030                 1035             


Arg Ile  Gln Pro Ala Phe Gly  Ala Asp His Asp Val  Pro Lys Arg 
    1040                 1045                 1050             


Lys Lys  Phe Pro Ala Ser Asn  Ile Ser Val Asn Asp  Ala Thr Ser 
    1055                 1060                 1065             


Ser Glu  Glu Lys Ser Glu Ala  Lys Gly Ala Glu Val  Asn Ala Val 
    1070                 1075                 1080             


Thr Ser  Asn Arg Ser Asp Pro  Leu Lys Asp Asp Pro  His Met Ser 
    1085                 1090                 1095             


Ser Asn  Val Thr Ser Asn Asp  Arg Leu Gly Glu Glu  Thr Asn Ala 
    1100                 1105                 1110             


Val Ser  Gly Pro Glu Glu Leu  Ser Val Ile Ser Gly  Asn Gly Glu 
    1115                 1120                 1125             


Cys Ser  Asn Ser Ser Gly Thr  Gly Lys Thr Ser Met  Pro Ser Gly 
    1130                 1135                 1140             


Asp Glu  Ser Ile Asp Glu Lys  Leu Gly Leu Ser Tyr  Lys Arg Glu 
    1145                 1150                 1155             


Arg Pro  Ser Gln Ala Gln Thr  Glu Ala Phe Trp Glu  Asn Lys Gln 
    1160                 1165                 1170             


Met Glu  Asn Asn Phe Tyr Lys  His Lys Ser Lys Thr  Lys His His 
    1175                 1180                 1185             


Ser Val  Ala Glu Glu Glu Thr  Leu Glu Lys His Leu  Arg Pro Lys 
    1190                 1195                 1200             


Gln Lys  Pro Lys Asn Ser Lys  His Cys Arg Asp Ala  Lys Phe Glu 
    1205                 1210                 1215             


Gly Thr  Arg Ile Pro His Leu  Val Lys Lys Arg Arg  Tyr Gln Lys 
    1220                 1225                 1230             


Gln Asp  Ser Glu Asn Lys Ser  Glu Ala Lys Glu Gln  Ser Asn Asp 
    1235                 1240                 1245             


Asp Tyr  Val Leu Glu Lys Leu  Phe Lys Lys Ser Val  Gly Val His 
    1250                 1255                 1260             


Ser Val  Met Lys His Asp Ala  Ile Met Asp Gly Ala  Ser Pro Asp 
    1265                 1270                 1275             


Tyr Val  Leu Val Glu Ala Glu  Ala Asn Arg Val Ala  Gln Asp Ala 
    1280                 1285                 1290             


Leu Lys  Ala Leu Arg Leu Ser  Arg Gln Arg Cys Leu  Gly Ala Val 
    1295                 1300                 1305             


Ser Gly  Val Pro Thr Trp Thr  Gly His Arg Gly Ile  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Gly Lys Lys Ser Arg  Phe Gly Lys Lys Arg  Asn Ser Asn 
    1325                 1330                 1335             


Phe Ser  Val Gln His Pro Ser  Ser Thr Ser Pro Thr  Glu Lys Cys 
    1340                 1345                 1350             


Gln Asp  Gly Ile Met Lys Lys  Glu Gly Lys Asp Asn  Val Pro Glu 
    1355                 1360                 1365             


His Phe  Ser Gly Arg Ala Glu  Asp Ala Asp Ser Ser  Ser Gly Pro 
    1370                 1375                 1380             


Leu Ala  Ser Ser Ser Leu Leu  Ala Lys Met Arg Ala  Arg Asn His 
    1385                 1390                 1395             


Leu Ile  Leu Pro Glu Arg Leu  Glu Ser Glu Ser Gly  His Leu Gln 
    1400                 1405                 1410             


Glu Ala  Ser Ala Leu Leu Pro  Thr Thr Glu His Asp  Asp Leu Leu 
    1415                 1420                 1425             


Val Glu  Met Arg Asn Phe Ile  Ala Phe Gln Ala His  Thr Asp Gly 
    1430                 1435                 1440             


Gln Ala  Ser Thr Arg Glu Ile  Leu Gln Glu Phe Glu  Ser Lys Leu 
    1445                 1450                 1455             


Ser Ala  Ser Gln Ser Cys Val  Phe Arg Glu Leu Leu  Arg Asn Leu 
    1460                 1465                 1470             


Cys Thr  Phe His Arg Thr Ser  Gly Gly Glu Gly Ile  Trp Lys Leu 
    1475                 1480                 1485             


Lys Pro  Glu Tyr Cys 
    1490             


<210>  5
<211>  1493
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Asn Glu Gly Ile Pro His Ser Ser Gln Thr Gln Glu Gln Asp 
1               5                   10                  15      


Cys Leu Gln Ser Gln Pro Val Ser Asn Asn Glu Glu Met Ala Ile Lys 
            20                  25                  30          


Gln Glu Ser Gly Gly Asp Gly Glu Val Glu Glu Tyr Leu Ser Phe Arg 
        35                  40                  45              


Ser Val Gly Asp Gly Leu Ser Thr Ser Ala Val Gly Cys Ala Ser Ala 
    50                  55                  60                  


Ala Pro Arg Arg Gly Pro Ala Leu Leu His Ile Asp Arg His Gln Ile 
65                  70                  75                  80  


Gln Ala Val Glu Pro Ser Ala Gln Ala Leu Glu Leu Gln Gly Leu Gly 
                85                  90                  95      


Val Asp Val Tyr Asp Gln Asp Val Leu Glu Gln Gly Val Leu Gln Gln 
            100                 105                 110         


Val Asp Asn Ala Ile His Glu Ala Ser Arg Ala Ser Gln Leu Val Asp 
        115                 120                 125             


Val Glu Lys Glu Tyr Arg Ser Val Leu Asp Asp Leu Thr Ser Cys Thr 
    130                 135                 140                 


Thr Ser Leu Arg Gln Ile Asn Lys Ile Ile Glu Gln Leu Ser Pro Gln 
145                 150                 155                 160 


Ala Ala Thr Ser Arg Asp Ile Asn Arg Lys Leu Asp Ser Val Lys Arg 
                165                 170                 175     


Gln Lys Tyr Asn Lys Glu Gln Gln Leu Lys Lys Ile Thr Ala Lys Gln 
            180                 185                 190         


Lys His Leu Gln Ala Ile Leu Gly Gly Ala Glu Val Lys Ile Glu Leu 
        195                 200                 205             


Asp His Ala Ser Leu Glu Glu Asp Ala Glu Pro Gly Pro Ser Ser Leu 
    210                 215                 220                 


Gly Ser Met Leu Met Pro Val Gln Glu Thr Ala Trp Glu Glu Leu Ile 
225                 230                 235                 240 


Arg Thr Gly Gln Met Thr Pro Phe Gly Thr Gln Ile Pro Gln Lys Gln 
                245                 250                 255     


Glu Lys Lys Pro Arg Lys Ile Met Leu Asn Glu Ala Ser Gly Phe Glu 
            260                 265                 270         


Lys Tyr Leu Ala Asp Gln Ala Lys Leu Ser Phe Glu Arg Lys Lys Gln 
        275                 280                 285             


Gly Cys Asn Lys Arg Ala Ala Arg Lys Ala Pro Ala Pro Val Thr Pro 
    290                 295                 300                 


Pro Ala Pro Val Gln Asn Lys Asn Lys Pro Asn Lys Lys Ala Arg Val 
305                 310                 315                 320 


Leu Ser Lys Lys Glu Glu Arg Leu Lys Lys His Ile Lys Lys Leu Gln 
                325                 330                 335     


Lys Arg Ala Leu Gln Phe Gln Gly Lys Val Gly Leu Pro Lys Ala Arg 
            340                 345                 350         


Arg Pro Trp Glu Ser Asp Met Arg Pro Glu Ala Glu Gly Asp Ser Glu 
        355                 360                 365             


Gly Glu Glu Ser Glu Tyr Phe Pro Thr Glu Glu Glu Glu Glu Glu Glu 
    370                 375                 380                 


Asp Asp Glu Val Glu Gly Ala Glu Ala Asp Leu Ser Gly Asp Gly Thr 
385                 390                 395                 400 


Asp Tyr Glu Leu Lys Pro Leu Pro Lys Gly Gly Lys Arg Gln Lys Lys 
                405                 410                 415     


Val Pro Val Gln Glu Ile Asp Asp Asp Phe Phe Pro Ser Ser Gly Glu 
            420                 425                 430         


Glu Ala Glu Ala Ala Ser Val Gly Glu Gly Gly Gly Gly Gly Arg Lys 
        435                 440                 445             


Val Gly Arg Tyr Arg Asp Asp Gly Asp Glu Asp Tyr Tyr Lys Gln Arg 
    450                 455                 460                 


Leu Arg Arg Trp Asn Lys Leu Arg Leu Gln Asp Lys Glu Lys Arg Leu 
465                 470                 475                 480 


Lys Leu Glu Asp Asp Ser Glu Glu Ser Asp Ala Glu Phe Asp Glu Gly 
                485                 490                 495     


Phe Lys Val Pro Gly Phe Leu Phe Lys Lys Leu Phe Lys Tyr Gln Gln 
            500                 505                 510         


Thr Gly Val Arg Trp Leu Trp Glu Leu His Cys Gln Gln Ala Gly Gly 
        515                 520                 525             


Ile Leu Gly Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ile Ile Ala 
    530                 535                 540                 


Phe Leu Ala Gly Leu Ser Tyr Ser Lys Ile Arg Thr Arg Gly Ser Asn 
545                 550                 555                 560 


Tyr Arg Phe Glu Gly Leu Gly Pro Thr Val Ile Val Cys Pro Thr Thr 
                565                 570                 575     


Val Met His Gln Trp Val Lys Glu Phe His Thr Trp Trp Pro Pro Phe 
            580                 585                 590         


Arg Val Ala Ile Leu His Glu Thr Gly Ser Tyr Thr His Lys Lys Glu 
        595                 600                 605             


Lys Leu Ile Arg Asp Val Ala His Cys His Gly Ile Leu Ile Thr Ser 
    610                 615                 620                 


Tyr Ser Tyr Ile Arg Leu Met Gln Asp Asp Ile Ser Arg Tyr Asp Trp 
625                 630                 635                 640 


His Tyr Val Ile Leu Asp Glu Gly His Lys Ile Arg Asn Pro Asn Ala 
                645                 650                 655     


Ala Val Thr Leu Ala Cys Lys Gln Phe Arg Thr Pro His Arg Ile Ile 
            660                 665                 670         


Leu Ser Gly Ser Pro Met Gln Asn Asn Leu Arg Glu Leu Trp Ser Leu 
        675                 680                 685             


Phe Asp Phe Ile Phe Pro Gly Lys Leu Gly Thr Leu Pro Val Phe Met 
    690                 695                 700                 


Glu Gln Phe Ser Val Pro Ile Thr Met Gly Gly Tyr Ser Asn Ala Ser 
705                 710                 715                 720 


Pro Val Gln Val Lys Thr Ala Tyr Lys Cys Ala Cys Val Leu Arg Asp 
                725                 730                 735     


Thr Ile Asn Pro Tyr Leu Leu Arg Arg Met Lys Ser Asp Val Lys Met 
            740                 745                 750         


Ser Leu Ser Leu Pro Asp Lys Asn Glu Gln Val Leu Phe Cys Arg Leu 
        755                 760                 765             


Thr Asp Glu Gln His Lys Val Tyr Gln Asn Phe Val Asp Ser Lys Glu 
    770                 775                 780                 


Val Tyr Arg Ile Leu Asn Gly Glu Met Gln Ile Phe Ser Gly Leu Ile 
785                 790                 795                 800 


Ala Leu Arg Lys Ile Cys Asn His Pro Asp Leu Phe Ser Gly Gly Pro 
                805                 810                 815     


Lys Asn Leu Lys Gly Leu Pro Asp Asp Glu Leu Glu Glu Asp Gln Phe 
            820                 825                 830         


Gly Tyr Trp Lys Arg Ser Gly Lys Met Ile Val Val Glu Ser Leu Leu 
        835                 840                 845             


Lys Ile Trp His Lys Gln Gly Gln Arg Val Leu Leu Phe Ser Gln Ser 
    850                 855                 860                 


Arg Gln Met Leu Asp Ile Leu Glu Val Phe Leu Arg Ala Gln Lys Tyr 
865                 870                 875                 880 


Thr Tyr Leu Lys Met Asp Gly Thr Thr Thr Ile Ala Ser Arg Gln Pro 
                885                 890                 895     


Leu Ile Thr Arg Tyr Asn Glu Asp Thr Ser Ile Phe Val Phe Leu Leu 
            900                 905                 910         


Thr Thr Arg Val Gly Gly Leu Gly Val Asn Leu Thr Gly Ala Asn Arg 
        915                 920                 925             


Val Val Ile Tyr Asp Pro Asp Trp Asn Pro Ser Thr Asp Thr Gln Ala 
    930                 935                 940                 


Arg Glu Arg Ala Trp Arg Ile Gly Gln Lys Lys Gln Val Thr Val Tyr 
945                 950                 955                 960 


Arg Leu Leu Thr Ala Gly Thr Ile Glu Glu Lys Ile Tyr His Arg Gln 
                965                 970                 975     


Ile Phe Lys Gln Phe Leu Thr Asn Arg Val Leu Lys Asp Pro Lys Gln 
            980                 985                 990         


Arg Arg Phe Phe Lys Ser Asn Asp  Leu Tyr Glu Leu Phe  Thr Leu Thr 
        995                 1000                 1005             


Ser Pro  Asp Ala Ser Gln Ser  Thr Glu Thr Ser Ala  Ile Phe Ala 
    1010                 1015                 1020             


Gly Thr  Gly Ser Asp Val Gln  Thr Pro Lys Cys His  Leu Lys Arg 
    1025                 1030                 1035             


Arg Ile  Gln Pro Ala Phe Gly  Ala Asp His Asp Val  Pro Lys Arg 
    1040                 1045                 1050             


Lys Lys  Phe Pro Ala Ser Asn  Ile Ser Val Asn Asp  Ala Thr Ser 
    1055                 1060                 1065             


Ser Glu  Glu Lys Ser Glu Ala  Lys Gly Ala Glu Val  Asn Ala Val 
    1070                 1075                 1080             


Thr Ser  Asn Arg Ser Asp Pro  Leu Lys Asp Asp Pro  His Met Ser 
    1085                 1090                 1095             


Ser Asn  Val Thr Ser Asn Asp  Arg Leu Gly Glu Glu  Thr Asn Ala 
    1100                 1105                 1110             


Val Ser  Gly Pro Glu Glu Leu  Ser Val Ile Ser Gly  Asn Gly Glu 
    1115                 1120                 1125             


Cys Ser  Asn Ser Ser Gly Thr  Gly Lys Thr Ser Met  Pro Ser Gly 
    1130                 1135                 1140             


Asp Glu  Ser Ile Asp Glu Lys  Leu Gly Leu Ser Tyr  Lys Arg Glu 
    1145                 1150                 1155             


Arg Pro  Ser Gln Ala Gln Thr  Glu Ala Phe Trp Glu  Asn Lys Gln 
    1160                 1165                 1170             


Met Glu  Asn Asn Phe Tyr Lys  His Lys Ser Lys Thr  Lys His His 
    1175                 1180                 1185             


Ser Val  Ala Glu Glu Glu Thr  Leu Glu Lys His Leu  Arg Pro Lys 
    1190                 1195                 1200             


Gln Lys  Pro Lys Asn Ser Lys  His Cys Arg Asp Ala  Lys Phe Glu 
    1205                 1210                 1215             


Gly Thr  Arg Ile Pro His Leu  Val Lys Lys Arg Arg  Tyr Gln Lys 
    1220                 1225                 1230             


Gln Asp  Ser Glu Asn Lys Ser  Glu Ala Lys Glu Gln  Ser Asn Asp 
    1235                 1240                 1245             


Asp Tyr  Val Leu Glu Lys Leu  Phe Lys Lys Ser Val  Gly Val His 
    1250                 1255                 1260             


Ser Val  Met Lys His Asp Ala  Ile Met Asp Gly Ala  Ser Pro Asp 
    1265                 1270                 1275             


Tyr Val  Leu Val Glu Ala Glu  Ala Asn Arg Val Ala  Gln Asp Ala 
    1280                 1285                 1290             


Leu Lys  Ala Leu Arg Leu Ser  Arg Gln Arg Cys Leu  Gly Ala Val 
    1295                 1300                 1305             


Ser Gly  Val Pro Thr Trp Thr  Gly His Arg Gly Ile  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Gly Lys Lys Ser Arg  Phe Gly Lys Lys Arg  Asn Ser Asn 
    1325                 1330                 1335             


Phe Ser  Val Gln His Pro Ser  Ser Thr Ser Pro Thr  Glu Lys Cys 
    1340                 1345                 1350             


Gln Asp  Gly Ile Met Lys Lys  Glu Gly Lys Asp Asn  Val Pro Glu 
    1355                 1360                 1365             


His Phe  Ser Gly Arg Ala Glu  Asp Ala Asp Ser Ser  Ser Gly Pro 
    1370                 1375                 1380             


Leu Ala  Ser Ser Ser Leu Leu  Ala Lys Met Arg Ala  Arg Asn His 
    1385                 1390                 1395             


Leu Ile  Leu Pro Glu Arg Leu  Glu Ser Glu Ser Gly  His Leu Gln 
    1400                 1405                 1410             


Glu Ala  Ser Ala Leu Leu Pro  Thr Thr Glu His Asp  Asp Leu Leu 
    1415                 1420                 1425             


Val Glu  Met Arg Asn Phe Ile  Ala Phe Gln Ala His  Thr Asp Gly 
    1430                 1435                 1440             


Gln Ala  Ser Thr Arg Glu Ile  Leu Gln Glu Phe Glu  Ser Lys Leu 
    1445                 1450                 1455             


Ser Ala  Ser Gln Ser Cys Val  Phe Arg Glu Leu Leu  Arg Asn Leu 
    1460                 1465                 1470             


Cys Thr  Phe His Arg Thr Ser  Gly Gly Glu Gly Ile  Trp Lys Leu 
    1475                 1480                 1485             


Lys Pro  Glu Tyr Cys 
    1490             


<210>  6
<211>  4296
<212>  DNA
<213>  Homo sapiens

<400>  6
atgagtgaaa aaaaattgga aacaactgca cagcagcgga aatgtcctga atggatgaat       60

gtgcagaata aaagatgtgc tgtagaagaa agaaaggcat gtgttcggaa gagtgttttt      120

gaagatgacc tccccttctt agaattcact ggatccattg tgtatagtta cgatgctagt      180

gattgctctt tcctgtcaga agatattagc atgagtctat cagatgggga tgtggtggga      240

tttgacatgg agtggccacc attatacaat agagggaaac ttggcaaagt tgcactaatt      300

cagttgtgtg tttctgagag caaatgttac ttgttccacg tttcttccat gtcagttttt      360

ccccagggat taaaaatgtt gcttgaaaat aaagcagtta aaaaggcagg tgtaggaatt      420

gaaggagatc agtggaaact tctacgtgac tttgatatca aattgaagaa ttttgtggag      480

ttgacagatg ttgccaataa aaagctgaaa tgcacagaga cctggagcct taacagtctg      540

gttaaacacc tcttaggtaa acagctcctg aaagacaagt ctatccgctg tagcaattgg      600

agtaaatttc ctctcactga ggaccagaaa ctgtatgcag ccactgatgc ttatgctggt      660

tttattattt accgaaattt agagattttg gatgatactg tgcaaaggtt tgctataaat      720

aaagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa      780

gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg      840

gtttctatct tactaaagga tatttcagaa aatctatatt cactgaggag gatgataatt      900

gggtctacta acattgagac tgaactgagg cccagcaata atttaaactt attatccttt      960

gaagattcaa ctactggggg agtacaacag aaacaaatta gagaacatga agttttaatt     1020

cacgttgaag atgaaacatg ggacccaaca cttgatcatt tagctaaaca tgatggagaa     1080

gatgtacttg gaaataaagt ggaacgaaaa gaagatggat ttgaagatgg agtagaagac     1140

aacaaattga aagagaatat ggaaagagct tgtttgatgt cgttagatat tacagaacat     1200

gaactccaaa ttttggaaca gcagtctcag gaagaatatc ttagtgatat tgcttataaa     1260

tctactgagc atttatctcc caatgataat gaaaacgata cgtcctatgt aattgagagt     1320

gatgaagatt tagaaatgga gatgcttaag catttatctc ccaatgataa tgaaaacgat     1380

acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa gtctttagaa     1440

aacctcaata gtggcacggt agaaccaact cattctaaat gcttaaaaat ggaaagaaat     1500

ctgggtcttc ctactaaaga agaagaagaa gatgatgaaa atgaagctaa tgaaggggaa     1560

gaagatgatg ataaggactt tttgtggcca gcacccaatg aagagcaagt tacttgcctc     1620

aagatgtact ttggccattc cagttttaaa ccagttcagt ggaaagtgat tcattcagta     1680

ttagaagaaa gaagagataa tgttgctgtc atggcaactg gatatggaaa gagtttgtgc     1740

ttccagtatc cacctgttta tgtaggcaag attggccttg ttatctctcc ccttatttct     1800

ctgatggaag accaagtgct acagcttaaa atgtccaaca tcccagcttg cttccttgga     1860

tcagcacagt cagaaaatgt tctaacagat attaaattag gtaaataccg gattgtatac     1920

gtaactccag aatactgttc aggtaacatg ggcctgctcc agcaacttga ggctgatatt     1980

ggtatcacgc tcattgctgt ggatgaggct cactgtattt ctgagtgggg gcatgatttt     2040

agggattcat tcaggaagtt gggctcccta aagacagcac tgccaatggt tccaatcgtt     2100

gcacttactg ctattgcaag ttcttcaatc cgggaagaca ttgtacgttg cttaaatctg     2160

agaaatcctc agatcacctg tactggtttt gatcgaccaa acctgtattt agaagttagg     2220

cgaaaaacag ggaatatcct tcaggatctg cagccatttc ttgtcaaaac aagttcccac     2280

tgggaatttg aaggtccaac aatcatctac tgtccttcta gaaaaatgac acaacaagtt     2340

acaggtgaac ttaggaaact gaatctatcc tgtggaacat accatgcggg catgagtttt     2400

agcacaagga aagacattca tcataggttt gtaagagatg aaattcagtg tgtcatagct     2460

accatagctt ttggaatggg cattaataaa gctgacattc gccaagtcat tcattacggt     2520

gctcctaagg acatggaatc atattatcag gagattggta gagctggtcg tgatggactt     2580

caaagttctt gtcacgtcct ctgggctcct gcagacatta acttaaatag gcaccttctt     2640

actgagatac gtaatgagaa gtttcgatta tacaaattaa agatgatggc aaagatggaa     2700

aaatatcttc attctagcag atgtaggaga caaatcatct tgtctcattt tgaggacaaa     2760

caagtacaaa aagcctcctt gggaattatg ggaactgaaa aatgctgtga taattgcagg     2820

tccagattgg atcattgcta ttccatggat gactcagagg atacatcctg ggactttggt     2880

ccacaagcat ttaagctttt gtctgctgtg gacatcttag gcgaaaaatt tggaattggg     2940

cttccaattt tatttctccg aggatctaat tctcagcgtc ttgccgatca atatcgcagg     3000

cacagtttat ttggcactgg caaggatcaa acagagagtt ggtggaaggc tttttcccgt     3060

cagctgatca ctgagggatt cttggtagaa gtttctcggt ataacaaatt tatgaagatt     3120

tgcgccctta cgaaaaaggg tagaaattgg cttcataaag ctaatacaga atctcagagc     3180

ctcatccttc aagctaatga agaattgtgt ccaaagaagt tgcttctgcc tagttcgaaa     3240

actgtatctt cgggcaccaa agagcattgt tataatcaag taccagttga attaagtaca     3300

gagaagaagt ctaacttgga gaagttatat tcttataaac catgtgataa gatttcttct     3360

gggagtaaca tttctaaaaa aagtatcatg gtacagtcac cagaaaaagc ttacagttcc     3420

tcacagcctg ttatttcggc acaagagcag gagactcaga ttgtgttata tggcaaattg     3480

gtagaagcta ggcagaaaca tgccaataaa atggatgttc ccccagctat tctggcaaca     3540

aacaagatac tggtggatat ggccaaaatg agaccaacta cggttgaaaa cgtaaaaagg     3600

attgatggtg tttctgaagg caaagctgcc atgttggccc ctctgttgga agtcatcaaa     3660

catttctgcc aaacaaatag tgttcagaca gacctctttt caagtacaaa acctcaagaa     3720

gaacagaaga cgagtctggt agcaaaaaat aaaatatgca cactttcaca gtctatggcc     3780

atcacatact ctttattcca agaaaagaag atgcctttga agagcatagc tgagagcagg     3840

attctgcctc tcatgacaat tggcatgcac ttatcccaag cggtgaaagc tggctgcccc     3900

cttgatttgg agcgagcagg cctgactcca gaggttcaga agattattgc tgatgttatc     3960

cgaaaccctc ccgtcaactc agatatgagt aaaattagcc taatcagaat gttagttcct     4020

gaaaacattg acacgtacct tatccacatg gcaattgaga tccttaaaca tggtcctgac     4080

agcggacttc aaccttcatg tgatgtcaac aaaaggagat gttttcccgg ttctgaagag     4140

atctgttcaa gttctaagag aagcaaggaa gaagtaggca tcaatactga gacttcatct     4200

gcagagagaa agagacgatt acctgtgtgg tttgccaaag gaagtgatac cagcaagaaa     4260

ttaatggaca aaacgaaaag gggaggtctt tttagt                               4296


<210>  7
<211>  4296
<212>  DNA
<213>  Homo sapiens

<400>  7
atgagtgaaa aaaaattgga aacaactgca cagcagcgga aatgtcctga atggatgaat       60

gtgcagaata aaagatgtgc tgtagaagaa agaaaggcat gtgttcggaa gagtgttttt      120

gaagatgacc tccccttctt agaattcact ggatccattg tgtatagtta cgatgctagt      180

gattgctctt tcctgtcaga agatattagc atgagtctat cagatgggga tgtggtggga      240

tttgacatgg agtggccacc attatacaat agagggaaac ttggcaaagt tgcactaatt      300

cagttgtgtg tttctgagag caaatgttac ttgttccacg tttcttccat gtcagttttt      360

ccccagggat taaaaatgtt gcttgaaaat aaagcagtta aaaaggcagg tgtaggaatt      420

gaaggagatc agtggaaact tctacgtgac tttgatatca aattgaagaa ttttgtggag      480

ttgacagatg ttgccaataa aaagctgaaa tgcacagaga cctggagcct taacagtctg      540

gttaaacacc tcttaggtaa acagctcctg aaagacaagt ctatccgctg tagcaattgg      600

agtaaatttc ctctcactga ggaccagaaa ctgtatgcag ccactgatgc ttatgctggt      660

tttattattt accgaaattt agagattttg gatgatactg tgcaaaggtt tgctataaat      720

aaagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa      780

gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg      840

gtttctatct tactaaagga tatttcagaa aatctatatt cactgaggag gatgataatt      900

gggtctacta acattgagac tgaactgagg cccagcaata atttaaactt attatccttt      960

gaagattcaa ctactggggg agtacaacag aaacaaatta gagaacatga agttttaatt     1020

cacgttgaag atgaaacatg ggacccaaca cttgatcatt tagctaaaca tgatggagaa     1080

gatgtacttg gaaataaagt ggaacgaaaa gaagatggat ttgaagatgg agtagaagac     1140

aacaaattga aagagaatat ggaaagagct tgtttgatgt cgttagatat tacagaacat     1200

gaactccaaa ttttggaaca gcagtctcag gaagaatatc ttagtgatat tgcttataaa     1260

tctactgagc atttatctcc caatgataat gaaaacgata cgtcctatgt aattgagagt     1320

gatgaagatt tagaaatgga gatgcttaag catttatctc ccaatgataa tgaaaacgat     1380

acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa gtctttagaa     1440

aacctcaata gtggcacggt agaaccaact cattctaaat gcttaaaaat ggaaagaaat     1500

ctgggtcttc ctactaaaga agaagaagaa gatgatgaaa atgaagctaa tgaaggggaa     1560

gaagatgatg ataaggactt tttgtggcca gcacccaatg aagagcaagt tacttgcctc     1620

aagatgtact ttggccattc cagttttaaa ccagttcagt ggaaagtgat tcattcagta     1680

ttagaagaaa gaagagataa tgttgctgtc atggcaactg gatatggaaa gagtttgtgc     1740

ttccagtatc cacctgttta tgtaggcaag attggccttg ttatctctcc ccttatttct     1800

ctgatggaag accaagtgct acagcttaaa atgtccaaca tcccagcttg cttccttgga     1860

tcagcacagt cagaaaatgt tctaacagat attaaattag gtaaataccg gattgtatac     1920

gtaactccag aatactgttc aggtaacatg ggcctgctcc agcaacttga ggctgatatt     1980

ggtatcacgc tcattgctgt ggatgaggct cactgtattt ctgagtgggg gcatgatttt     2040

agggattcat tcaggaagtt gggctcccta aagacagcac tgccaatggt tccaatcgtt     2100

gcacttactg ctactgcaag ttcttcaatc cgggaagaca ttgtacgttg cttaaatctg     2160

agaaatcctc agatcacctg tactggtttt gatcgaccaa acctgtattt agaagttagg     2220

cgaaaaacag ggaatatcct tcaggatctg cagccatttc ttgtcaaaac aagttcccac     2280

tgggaatttg aaggtccaac aatcatctac tgtccttcta gaaaaatgac acaacaagtt     2340

acaggtgaac ttaggaaact gaatctatcc tgtggaacat accatgcggg catgagtttt     2400

agcacaagga aagacattca tcataggttt gtaagagatg aaattcagtg tgtcatagct     2460

accatagctt ttggaatggg cattaataaa gctgacattc gccaagtcat tcattacggt     2520

gctcctaagg acatggaatc atattatcag gagattggta gagctggtcg tgatggactt     2580

caaagttctt gtcacgtcct ctgggctcct gcagacatta acttaaatag gcaccttctt     2640

actgagatac gtaatgagaa gtttcgatta tacaaattaa agatgatggc aaagatggaa     2700

aaatatcttc attctagcag atgtaggaga caaatcatct tgtctcattt tgaggacaaa     2760

caagtacaaa aagcctcctt gggaattatg ggaactgaaa aatgctgtga taattgcagg     2820

tccagattgg atcattgcta ttccatggat gactcagagg atacatcctg ggactttggt     2880

ccacaagcat ttaagctttt gtctgctgtg gacatcttag gcgaaaaatt tggaattggg     2940

cttccaattt tatttctccg aggatctaat tctcagcgtc ttgccgatca atatcgcagg     3000

cacagtttat ttggcactgg caaggatcaa acagagagtt ggtggaaggc tttttcccgt     3060

cagctgatca ctgagggatt cttggtagaa gtttctcggt ataacaaatt tatgaagatt     3120

tgcgccctta cgaaaaaggg tagaaattgg cttcataaag ctaatacaga atctcagagc     3180

ctcatccttc aagctaatga agaattgtgt ccaaagaagt tgcttctgcc tagttcgaaa     3240

actgtatctt cgggcaccaa agagcattgt tataatcaag taccagttga attaagtaca     3300

gagaagaagt ctaacttgga gaagttatat tcttataaac catgtgataa gatttcttct     3360

gggagtaaca tttctaaaaa aagtatcatg gtacagtcac cagaaaaagc ttacagttcc     3420

tcacagcctg ttatttcggc acaagagcag gagactcaga ttgtgttata tggcaaattg     3480

gtagaagcta ggcagaaaca tgccaataaa atggatgttc ccccagctat tctggcaaca     3540

aacaagatac tggtggatat ggccaaaatg agaccaacta cggttgaaaa cgtaaaaagg     3600

attgatggtg tttctgaagg caaagctgcc atgttggccc ctctgttgga agtcatcaaa     3660

catttctgcc aaacaaatag tgttcagaca gacctctttt caagtacaaa acctcaagaa     3720

gaacagaaga cgagtctggt agcaaaaaat aaaatatgca cactttcaca gtctatggcc     3780

atcacatact ctttattcca agaaaagaag atgcctttga agagcatagc tgagagcagg     3840

attctgcctc tcatgacaat tggcatgcac ttatcccaag cggtgaaagc tggctgcccc     3900

cttgatttgg agcgagcagg cctgactcca gaggttcaga agattattgc tgatgttatc     3960

cgaaaccctc ccgtcaactc agatatgagt aaaattagcc taatcagaat gttagttcct     4020

gaaaacattg acacgtacct tatccacatg gcaattgaga tccttaaaca tggtcctgac     4080

agcggacttc aaccttcatg tgatgtcaac aaaaggagat gttttcccgg ttctgaagag     4140

atctgttcaa gttctaagag aagcaaggaa gaagtaggca tcaatactga gacttcatct     4200

gcagagagaa agagacgatt acctgtgtgg tttgccaaag gaagtgatac cagcaagaaa     4260

ttaatggaca aaacgaaaag gggaggtctt tttagt                               4296


<210>  8
<211>  5765
<212>  DNA
<213>  Homo sapiens

<400>  8
cagccgcccc tcctgcggcc gctgcggggg ccgccgcctg acttcggaca ccggccccgc       60

acccgccagg aggggaggga aggggaggcg gggagagcga cggcgggggg cgggcggtgg      120

accccgcctc ccccggcaca gcctgctgag gggaagaggg ggtctccgct cttcctcagt      180

gcactctctg actgaagccc ggcgcgtggg gtgcagcggg agtgcgaggg gactggacag      240

gtgggaagat gggaatgagg accgggcggc gggaatgttc tcacttctcc ggattccacc      300

gggatgcagg actctagctg cccagccgca cctgcgaaga gactacactt cccgaggtgc      360

tcagcggcag cgagggcctc cacgcatgcg caccgcggcg cgctgggcgg ggctggatgg      420

gctgtggtgg gagggttgca gcgccgcgag aaaggcgagc cgggccgggg gcggggaaag      480

gggtggggca ggaacggggg cggggacggc gctggagggg cgggtcgggt aggtctcccg      540

gagctgatgt gtactgtgtg cgccggggag gcgccggctt gtactcggca gcgcgggaat      600

aaagtttgct gatttggtgt ctagcctgga tgcctgggtt gcaggccctg cttgtggtgg      660

cgctccacag tcatccggct gaagaagacc tgttggactg gatcttctcg ggttttcttt      720

cagatattgt tttgtattta cccatgaaga cattgttttt tggactctgc aaataggaca      780

tttcaaagat gagtgaaaaa aaattggaaa caactgcaca gcagcggaaa tgtcctgaat      840

ggatgaatgt gcagaataaa agatgtgctg tagaagaaag aaaggcatgt gttcggaaga      900

gtgtttttga agatgacctc cccttcttag aattcactgg atccattgtg tatagttacg      960

atgctagtga ttgctctttc ctgtcagaag atattagcat gagtctatca gatggggatg     1020

tggtgggatt tgacatggag tggccaccat tatacaatag agggaaactt ggcaaagttg     1080

cactaattca gttgtgtgtt tctgagagca aatgttactt gttccacgtt tcttccatgt     1140

cagtttttcc ccagggatta aaaatgttgc ttgaaaataa agcagttaaa aaggcaggtg     1200

taggaattga aggagatcag tggaaacttc tacgtgactt tgatatcaaa ttgaagaatt     1260

ttgtggagtt gacagatgtt gccaataaaa agctgaaatg cacagagacc tggagcctta     1320

acagtctggt taaacacctc ttaggtaaac agctcctgaa agacaagtct atccgctgta     1380

gcaattggag taaatttcct ctcactgagg accagaaact gtatgcagcc actgatgctt     1440

atgctggttt tattatttac cgaaatttag agattttgga tgatactgtg caaaggtttg     1500

ctataaataa agaggaagaa atcctactta gcgacatgaa caaacagttg acttcaatct     1560

ctgaggaagt gatggatctg gctaagcatc ttcctcatgc tttcagtaaa ttggaaaacc     1620

cacggagggt ttctatctta ctaaaggata tttcagaaaa tctatattca ctgaggagga     1680

tgataattgg gtctactaac attgagactg aactgaggcc cagcaataat ttaaacttat     1740

tatcctttga agattcaact actgggggag tacaacagaa acaaattaga gaacatgaag     1800

ttttaattca cgttgaagat gaaacatggg acccaacact tgatcattta gctaaacatg     1860

atggagaaga tgtacttgga aataaagtgg aacgaaaaga agatggattt gaagatggag     1920

tagaagacaa caaattgaaa gagaatatgg aaagagcttg tttgatgtcg ttagatatta     1980

cagaacatga actccaaatt ttggaacagc agtctcagga agaatatctt agtgatattg     2040

cttataaatc tactgagcat ttatctccca atgataatga aaacgatacg tcctatgtaa     2100

ttgagagtga tgaagattta gaaatggaga tgcttaagca tttatctccc aatgataatg     2160

aaaacgatac gtcctatgta attgagagtg atgaagattt agaaatggag atgcttaagt     2220

ctttagaaaa cctcaatagt ggcacggtag aaccaactca ttctaaatgc ttaaaaatgg     2280

aaagaaatct gggtcttcct actaaagaag aagaagaaga tgatgaaaat gaagctaatg     2340

aaggggaaga agatgatgat aaggactttt tgtggccagc acccaatgaa gagcaagtta     2400

cttgcctcaa gatgtacttt ggccattcca gttttaaacc agttcagtgg aaagtgattc     2460

attcagtatt agaagaaaga agagataatg ttgctgtcat ggcaactgga tatggaaaga     2520

gtttgtgctt ccagtatcca cctgtttatg taggcaagat tggccttgtt atctctcccc     2580

ttatttctct gatggaagac caagtgctac agcttaaaat gtccaacatc ccagcttgct     2640

tccttggatc agcacagtca gaaaatgttc taacagatat taaattaggt aaataccgga     2700

ttgtatacgt aactccagaa tactgttcag gtaacatggg cctgctccag caacttgagg     2760

ctgatattgg tatcacgctc attgctgtgg atgaggctca ctgtatttct gagtgggggc     2820

atgattttag ggattcattc aggaagttgg gctccctaaa gacagcactg ccaatggttc     2880

caatcgttgc acttactgct actgcaagtt cttcaatccg ggaagacatt gtacgttgct     2940

taaatctgag aaatcctcag atcacctgta ctggttttga tcgaccaaac ctgtatttag     3000

aagttaggcg aaaaacaggg aatatccttc aggatctgca gccatttctt gtcaaaacaa     3060

gttcccactg ggaatttgaa ggtccaacaa tcatctactg tccttctaga aaaatgacac     3120

aacaagttac aggtgaactt aggaaactga atctatcctg tggaacatac catgcgggca     3180

tgagttttag cacaaggaaa gacattcatc ataggtttgt aagagatgaa attcagtgtg     3240

tcatagctac catagctttt ggaatgggca ttaataaagc tgacattcgc caagtcattc     3300

attacggtgc tcctaaggac atggaatcat attatcagga gattggtaga gctggtcgtg     3360

atggacttca aagttcttgt cacgtcctct gggctcctgc agacattaac ttaaataggc     3420

accttcttac tgagatacgt aatgagaagt ttcgattata caaattaaag atgatggcaa     3480

agatggaaaa atatcttcat tctagcagat gtaggagaca aatcatcttg tctcattttg     3540

aggacaaaca agtacaaaaa gcctccttgg gaattatggg aactgaaaaa tgctgtgata     3600

attgcaggtc cagattggat cattgctatt ccatggatga ctcagaggat acatcctggg     3660

actttggtcc acaagcattt aagcttttgt ctgctgtgga catcttaggc gaaaaatttg     3720

gaattgggct tccaatttta tttctccgag gatctaattc tcagcgtctt gccgatcaat     3780

atcgcaggca cagtttattt ggcactggca aggatcaaac agagagttgg tggaaggctt     3840

tttcccgtca gctgatcact gagggattct tggtagaagt ttctcggtat aacaaattta     3900

tgaagatttg cgcccttacg aaaaagggta gaaattggct tcataaagct aatacagaat     3960

ctcagagcct catccttcaa gctaatgaag aattgtgtcc aaagaagttg cttctgccta     4020

gttcgaaaac tgtatcttcg ggcaccaaag agcattgtta taatcaagta ccagttgaat     4080

taagtacaga gaagaagtct aacttggaga agttatattc ttataaacca tgtgataaga     4140

tttcttctgg gagtaacatt tctaaaaaaa gtatcatggt acagtcacca gaaaaagctt     4200

acagttcctc acagcctgtt atttcggcac aagagcagga gactcagatt gtgttatatg     4260

gcaaattggt agaagctagg cagaaacatg ccaataaaat ggatgttccc ccagctattc     4320

tggcaacaaa caagatactg gtggatatgg ccaaaatgag accaactacg gttgaaaacg     4380

taaaaaggat tgatggtgtt tctgaaggca aagctgccat gttggcccct ctgttggaag     4440

tcatcaaaca tttctgccaa acaaatagtg ttcagacaga cctcttttca agtacaaaac     4500

ctcaagaaga acagaagacg agtctggtag caaaaaataa aatatgcaca ctttcacagt     4560

ctatggccat cacatactct ttattccaag aaaagaagat gcctttgaag agcatagctg     4620

agagcaggat tctgcctctc atgacaattg gcatgcactt atcccaagcg gtgaaagctg     4680

gctgccccct tgatttggag cgagcaggcc tgactccaga ggttcagaag attattgctg     4740

atgttatccg aaaccctccc gtcaactcag atatgagtaa aattagccta atcagaatgt     4800

tagttcctga aaacattgac acgtacctta tccacatggc aattgagatc cttaaacatg     4860

gtcctgacag cggacttcaa ccttcatgtg atgtcaacaa aaggagatgt tttcccggtt     4920

ctgaagagat ctgttcaagt tctaagagaa gcaaggaaga agtaggcatc aatactgaga     4980

cttcatctgc agagagaaag agacgattac ctgtgtggtt tgccaaagga agtgatacca     5040

gcaagaaatt aatggacaaa acgaaaaggg gaggtctttt tagttaagct ggcaattacc     5100

agaacaatta tgtttcttgc tgtattataa gaggatagct atattttatt tctgaagagt     5160

aaggagtagt attttggctt aaaaatcatt ctaattacaa agttcactgt ttattgaaga     5220

actggcatct taaatcagcc ttccgcaatt catgtagttt ctgggtcttc tgggagccta     5280

cgtgagtaca tcacctaaca gaatattaaa ttagacttcc tgtaagattg ctttaagaaa     5340

ctgttactgt cctgttttct aatctcttta ttaaaacagt gtatttggaa aatgttatgt     5400

gctctgattt gatatagata acagattagt agttacatgg taattatgtg atataaaata     5460

ttcatatatt atcaaaattc tgttttgtaa atgtaagaaa gcatagttat tttacaaatt     5520

gtttttactg tcttttgaag aagttcttaa atacgttgtt aaatggtatt agttgaccag     5580

ggcagtgaaa atgaaaccgc attttgggtg ccattaaata gggaaaaaac atgtaaaaaa     5640

tgtaaaatgg agaccaattg cactaggcaa gtgtatattt tgtattttat atacaatttc     5700

tattattttt caagtaataa aacaatgttt ttcatactga atattaaaaa aaaaaaaaaa     5760

aaaaa                                                                 5765


<210>  9
<211>  1432
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gln Gln Arg Lys Cys Pro 
1               5                   10                  15      


Glu Trp Met Asn Val Gln Asn Lys Arg Cys Ala Val Glu Glu Arg Lys 
            20                  25                  30          


Ala Cys Val Arg Lys Ser Val Phe Glu Asp Asp Leu Pro Phe Leu Glu 
        35                  40                  45              


Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Ala Ser Asp Cys Ser Phe 
    50                  55                  60                  


Leu Ser Glu Asp Ile Ser Met Ser Leu Ser Asp Gly Asp Val Val Gly 
65                  70                  75                  80  


Phe Asp Met Glu Trp Pro Pro Leu Tyr Asn Arg Gly Lys Leu Gly Lys 
                85                  90                  95      


Val Ala Leu Ile Gln Leu Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe 
            100                 105                 110         


His Val Ser Ser Met Ser Val Phe Pro Gln Gly Leu Lys Met Leu Leu 
        115                 120                 125             


Glu Asn Lys Ala Val Lys Lys Ala Gly Val Gly Ile Glu Gly Asp Gln 
    130                 135                 140                 


Trp Lys Leu Leu Arg Asp Phe Asp Ile Lys Leu Lys Asn Phe Val Glu 
145                 150                 155                 160 


Leu Thr Asp Val Ala Asn Lys Lys Leu Lys Cys Thr Glu Thr Trp Ser 
                165                 170                 175     


Leu Asn Ser Leu Val Lys His Leu Leu Gly Lys Gln Leu Leu Lys Asp 
            180                 185                 190         


Lys Ser Ile Arg Cys Ser Asn Trp Ser Lys Phe Pro Leu Thr Glu Asp 
        195                 200                 205             


Gln Lys Leu Tyr Ala Ala Thr Asp Ala Tyr Ala Gly Phe Ile Ile Tyr 
    210                 215                 220                 


Arg Asn Leu Glu Ile Leu Asp Asp Thr Val Gln Arg Phe Ala Ile Asn 
225                 230                 235                 240 


Lys Glu Glu Glu Ile Leu Leu Ser Asp Met Asn Lys Gln Leu Thr Ser 
                245                 250                 255     


Ile Ser Glu Glu Val Met Asp Leu Ala Lys His Leu Pro His Ala Phe 
            260                 265                 270         


Ser Lys Leu Glu Asn Pro Arg Arg Val Ser Ile Leu Leu Lys Asp Ile 
        275                 280                 285             


Ser Glu Asn Leu Tyr Ser Leu Arg Arg Met Ile Ile Gly Ser Thr Asn 
    290                 295                 300                 


Ile Glu Thr Glu Leu Arg Pro Ser Asn Asn Leu Asn Leu Leu Ser Phe 
305                 310                 315                 320 


Glu Asp Ser Thr Thr Gly Gly Val Gln Gln Lys Gln Ile Arg Glu His 
                325                 330                 335     


Glu Val Leu Ile His Val Glu Asp Glu Thr Trp Asp Pro Thr Leu Asp 
            340                 345                 350         


His Leu Ala Lys His Asp Gly Glu Asp Val Leu Gly Asn Lys Val Glu 
        355                 360                 365             


Arg Lys Glu Asp Gly Phe Glu Asp Gly Val Glu Asp Asn Lys Leu Lys 
    370                 375                 380                 


Glu Asn Met Glu Arg Ala Cys Leu Met Ser Leu Asp Ile Thr Glu His 
385                 390                 395                 400 


Glu Leu Gln Ile Leu Glu Gln Gln Ser Gln Glu Glu Tyr Leu Ser Asp 
                405                 410                 415     


Ile Ala Tyr Lys Ser Thr Glu His Leu Ser Pro Asn Asp Asn Glu Asn 
            420                 425                 430         


Asp Thr Ser Tyr Val Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met 
        435                 440                 445             


Leu Lys His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val 
    450                 455                 460                 


Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys Ser Leu Glu 
465                 470                 475                 480 


Asn Leu Asn Ser Gly Thr Val Glu Pro Thr His Ser Lys Cys Leu Lys 
                485                 490                 495     


Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Glu Glu Asp Asp 
            500                 505                 510         


Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Lys Asp Phe Leu 
        515                 520                 525             


Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Lys Met Tyr Phe 
    530                 535                 540                 


Gly His Ser Ser Phe Lys Pro Val Gln Trp Lys Val Ile His Ser Val 
545                 550                 555                 560 


Leu Glu Glu Arg Arg Asp Asn Val Ala Val Met Ala Thr Gly Tyr Gly 
                565                 570                 575     


Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gly Lys Ile Gly 
            580                 585                 590         


Leu Val Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gln Val Leu Gln 
        595                 600                 605             


Leu Lys Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Ser Ala Gln Ser 
    610                 615                 620                 


Glu Asn Val Leu Thr Asp Ile Lys Leu Gly Lys Tyr Arg Ile Val Tyr 
625                 630                 635                 640 


Val Thr Pro Glu Tyr Cys Ser Gly Asn Met Gly Leu Leu Gln Gln Leu 
                645                 650                 655     


Glu Ala Asp Ile Gly Ile Thr Leu Ile Ala Val Asp Glu Ala His Cys 
            660                 665                 670         


Ile Ser Glu Trp Gly His Asp Phe Arg Asp Ser Phe Arg Lys Leu Gly 
        675                 680                 685             


Ser Leu Lys Thr Ala Leu Pro Met Val Pro Ile Val Ala Leu Thr Ala 
    690                 695                 700                 


Ile Ala Ser Ser Ser Ile Arg Glu Asp Ile Val Arg Cys Leu Asn Leu 
705                 710                 715                 720 


Arg Asn Pro Gln Ile Thr Cys Thr Gly Phe Asp Arg Pro Asn Leu Tyr 
                725                 730                 735     


Leu Glu Val Arg Arg Lys Thr Gly Asn Ile Leu Gln Asp Leu Gln Pro 
            740                 745                 750         


Phe Leu Val Lys Thr Ser Ser His Trp Glu Phe Glu Gly Pro Thr Ile 
        755                 760                 765             


Ile Tyr Cys Pro Ser Arg Lys Met Thr Gln Gln Val Thr Gly Glu Leu 
    770                 775                 780                 


Arg Lys Leu Asn Leu Ser Cys Gly Thr Tyr His Ala Gly Met Ser Phe 
785                 790                 795                 800 


Ser Thr Arg Lys Asp Ile His His Arg Phe Val Arg Asp Glu Ile Gln 
                805                 810                 815     


Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gly Ile Asn Lys Ala Asp 
            820                 825                 830         


Ile Arg Gln Val Ile His Tyr Gly Ala Pro Lys Asp Met Glu Ser Tyr 
        835                 840                 845             


Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Ser Ser Cys 
    850                 855                 860                 


His Val Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn Arg His Leu Leu 
865                 870                 875                 880 


Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Leu Lys Met Met 
                885                 890                 895     


Ala Lys Met Glu Lys Tyr Leu His Ser Ser Arg Cys Arg Arg Gln Ile 
            900                 905                 910         


Ile Leu Ser His Phe Glu Asp Lys Gln Val Gln Lys Ala Ser Leu Gly 
        915                 920                 925             


Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Ser Arg Leu Asp 
    930                 935                 940                 


His Cys Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Trp Asp Phe Gly 
945                 950                 955                 960 


Pro Gln Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Leu Gly Glu Lys 
                965                 970                 975     


Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Ser Asn Ser Gln 
            980                 985                 990         


Arg Leu Ala Asp Gln Tyr Arg Arg  His Ser Leu Phe Gly  Thr Gly Lys 
        995                 1000                 1005             


Asp Gln  Thr Glu Ser Trp Trp  Lys Ala Phe Ser Arg  Gln Leu Ile 
    1010                 1015                 1020             


Thr Glu  Gly Phe Leu Val Glu  Val Ser Arg Tyr Asn  Lys Phe Met 
    1025                 1030                 1035             


Lys Ile  Cys Ala Leu Thr Lys  Lys Gly Arg Asn Trp  Leu His Lys 
    1040                 1045                 1050             


Ala Asn  Thr Glu Ser Gln Ser  Leu Ile Leu Gln Ala  Asn Glu Glu 
    1055                 1060                 1065             


Leu Cys  Pro Lys Lys Leu Leu  Leu Pro Ser Ser Lys  Thr Val Ser 
    1070                 1075                 1080             


Ser Gly  Thr Lys Glu His Cys  Tyr Asn Gln Val Pro  Val Glu Leu 
    1085                 1090                 1095             


Ser Thr  Glu Lys Lys Ser Asn  Leu Glu Lys Leu Tyr  Ser Tyr Lys 
    1100                 1105                 1110             


Pro Cys  Asp Lys Ile Ser Ser  Gly Ser Asn Ile Ser  Lys Lys Ser 
    1115                 1120                 1125             


Ile Met  Val Gln Ser Pro Glu  Lys Ala Tyr Ser Ser  Ser Gln Pro 
    1130                 1135                 1140             


Val Ile  Ser Ala Gln Glu Gln  Glu Thr Gln Ile Val  Leu Tyr Gly 
    1145                 1150                 1155             


Lys Leu  Val Glu Ala Arg Gln  Lys His Ala Asn Lys  Met Asp Val 
    1160                 1165                 1170             


Pro Pro  Ala Ile Leu Ala Thr  Asn Lys Ile Leu Val  Asp Met Ala 
    1175                 1180                 1185             


Lys Met  Arg Pro Thr Thr Val  Glu Asn Val Lys Arg  Ile Asp Gly 
    1190                 1195                 1200             


Val Ser  Glu Gly Lys Ala Ala  Met Leu Ala Pro Leu  Leu Glu Val 
    1205                 1210                 1215             


Ile Lys  His Phe Cys Gln Thr  Asn Ser Val Gln Thr  Asp Leu Phe 
    1220                 1225                 1230             


Ser Ser  Thr Lys Pro Gln Glu  Glu Gln Lys Thr Ser  Leu Val Ala 
    1235                 1240                 1245             


Lys Asn  Lys Ile Cys Thr Leu  Ser Gln Ser Met Ala  Ile Thr Tyr 
    1250                 1255                 1260             


Ser Leu  Phe Gln Glu Lys Lys  Met Pro Leu Lys Ser  Ile Ala Glu 
    1265                 1270                 1275             


Ser Arg  Ile Leu Pro Leu Met  Thr Ile Gly Met His  Leu Ser Gln 
    1280                 1285                 1290             


Ala Val  Lys Ala Gly Cys Pro  Leu Asp Leu Glu Arg  Ala Gly Leu 
    1295                 1300                 1305             


Thr Pro  Glu Val Gln Lys Ile  Ile Ala Asp Val Ile  Arg Asn Pro 
    1310                 1315                 1320             


Pro Val  Asn Ser Asp Met Ser  Lys Ile Ser Leu Ile  Arg Met Leu 
    1325                 1330                 1335             


Val Pro  Glu Asn Ile Asp Thr  Tyr Leu Ile His Met  Ala Ile Glu 
    1340                 1345                 1350             


Ile Leu  Lys His Gly Pro Asp  Ser Gly Leu Gln Pro  Ser Cys Asp 
    1355                 1360                 1365             


Val Asn  Lys Arg Arg Cys Phe  Pro Gly Ser Glu Glu  Ile Cys Ser 
    1370                 1375                 1380             


Ser Ser  Lys Arg Ser Lys Glu  Glu Val Gly Ile Asn  Thr Glu Thr 
    1385                 1390                 1395             


Ser Ser  Ala Glu Arg Lys Arg  Arg Leu Pro Val Trp  Phe Ala Lys 
    1400                 1405                 1410             


Gly Ser  Asp Thr Ser Lys Lys  Leu Met Asp Lys Thr  Lys Arg Gly 
    1415                 1420                 1425             


Gly Leu  Phe Ser 
    1430         


<210>  10
<211>  1432
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gln Gln Arg Lys Cys Pro 
1               5                   10                  15      


Glu Trp Met Asn Val Gln Asn Lys Arg Cys Ala Val Glu Glu Arg Lys 
            20                  25                  30          


Ala Cys Val Arg Lys Ser Val Phe Glu Asp Asp Leu Pro Phe Leu Glu 
        35                  40                  45              


Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Ala Ser Asp Cys Ser Phe 
    50                  55                  60                  


Leu Ser Glu Asp Ile Ser Met Ser Leu Ser Asp Gly Asp Val Val Gly 
65                  70                  75                  80  


Phe Asp Met Glu Trp Pro Pro Leu Tyr Asn Arg Gly Lys Leu Gly Lys 
                85                  90                  95      


Val Ala Leu Ile Gln Leu Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe 
            100                 105                 110         


His Val Ser Ser Met Ser Val Phe Pro Gln Gly Leu Lys Met Leu Leu 
        115                 120                 125             


Glu Asn Lys Ala Val Lys Lys Ala Gly Val Gly Ile Glu Gly Asp Gln 
    130                 135                 140                 


Trp Lys Leu Leu Arg Asp Phe Asp Ile Lys Leu Lys Asn Phe Val Glu 
145                 150                 155                 160 


Leu Thr Asp Val Ala Asn Lys Lys Leu Lys Cys Thr Glu Thr Trp Ser 
                165                 170                 175     


Leu Asn Ser Leu Val Lys His Leu Leu Gly Lys Gln Leu Leu Lys Asp 
            180                 185                 190         


Lys Ser Ile Arg Cys Ser Asn Trp Ser Lys Phe Pro Leu Thr Glu Asp 
        195                 200                 205             


Gln Lys Leu Tyr Ala Ala Thr Asp Ala Tyr Ala Gly Phe Ile Ile Tyr 
    210                 215                 220                 


Arg Asn Leu Glu Ile Leu Asp Asp Thr Val Gln Arg Phe Ala Ile Asn 
225                 230                 235                 240 


Lys Glu Glu Glu Ile Leu Leu Ser Asp Met Asn Lys Gln Leu Thr Ser 
                245                 250                 255     


Ile Ser Glu Glu Val Met Asp Leu Ala Lys His Leu Pro His Ala Phe 
            260                 265                 270         


Ser Lys Leu Glu Asn Pro Arg Arg Val Ser Ile Leu Leu Lys Asp Ile 
        275                 280                 285             


Ser Glu Asn Leu Tyr Ser Leu Arg Arg Met Ile Ile Gly Ser Thr Asn 
    290                 295                 300                 


Ile Glu Thr Glu Leu Arg Pro Ser Asn Asn Leu Asn Leu Leu Ser Phe 
305                 310                 315                 320 


Glu Asp Ser Thr Thr Gly Gly Val Gln Gln Lys Gln Ile Arg Glu His 
                325                 330                 335     


Glu Val Leu Ile His Val Glu Asp Glu Thr Trp Asp Pro Thr Leu Asp 
            340                 345                 350         


His Leu Ala Lys His Asp Gly Glu Asp Val Leu Gly Asn Lys Val Glu 
        355                 360                 365             


Arg Lys Glu Asp Gly Phe Glu Asp Gly Val Glu Asp Asn Lys Leu Lys 
    370                 375                 380                 


Glu Asn Met Glu Arg Ala Cys Leu Met Ser Leu Asp Ile Thr Glu His 
385                 390                 395                 400 


Glu Leu Gln Ile Leu Glu Gln Gln Ser Gln Glu Glu Tyr Leu Ser Asp 
                405                 410                 415     


Ile Ala Tyr Lys Ser Thr Glu His Leu Ser Pro Asn Asp Asn Glu Asn 
            420                 425                 430         


Asp Thr Ser Tyr Val Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met 
        435                 440                 445             


Leu Lys His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val 
    450                 455                 460                 


Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys Ser Leu Glu 
465                 470                 475                 480 


Asn Leu Asn Ser Gly Thr Val Glu Pro Thr His Ser Lys Cys Leu Lys 
                485                 490                 495     


Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Glu Glu Asp Asp 
            500                 505                 510         


Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Lys Asp Phe Leu 
        515                 520                 525             


Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Lys Met Tyr Phe 
    530                 535                 540                 


Gly His Ser Ser Phe Lys Pro Val Gln Trp Lys Val Ile His Ser Val 
545                 550                 555                 560 


Leu Glu Glu Arg Arg Asp Asn Val Ala Val Met Ala Thr Gly Tyr Gly 
                565                 570                 575     


Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gly Lys Ile Gly 
            580                 585                 590         


Leu Val Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gln Val Leu Gln 
        595                 600                 605             


Leu Lys Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Ser Ala Gln Ser 
    610                 615                 620                 


Glu Asn Val Leu Thr Asp Ile Lys Leu Gly Lys Tyr Arg Ile Val Tyr 
625                 630                 635                 640 


Val Thr Pro Glu Tyr Cys Ser Gly Asn Met Gly Leu Leu Gln Gln Leu 
                645                 650                 655     


Glu Ala Asp Ile Gly Ile Thr Leu Ile Ala Val Asp Glu Ala His Cys 
            660                 665                 670         


Ile Ser Glu Trp Gly His Asp Phe Arg Asp Ser Phe Arg Lys Leu Gly 
        675                 680                 685             


Ser Leu Lys Thr Ala Leu Pro Met Val Pro Ile Val Ala Leu Thr Ala 
    690                 695                 700                 


Thr Ala Ser Ser Ser Ile Arg Glu Asp Ile Val Arg Cys Leu Asn Leu 
705                 710                 715                 720 


Arg Asn Pro Gln Ile Thr Cys Thr Gly Phe Asp Arg Pro Asn Leu Tyr 
                725                 730                 735     


Leu Glu Val Arg Arg Lys Thr Gly Asn Ile Leu Gln Asp Leu Gln Pro 
            740                 745                 750         


Phe Leu Val Lys Thr Ser Ser His Trp Glu Phe Glu Gly Pro Thr Ile 
        755                 760                 765             


Ile Tyr Cys Pro Ser Arg Lys Met Thr Gln Gln Val Thr Gly Glu Leu 
    770                 775                 780                 


Arg Lys Leu Asn Leu Ser Cys Gly Thr Tyr His Ala Gly Met Ser Phe 
785                 790                 795                 800 


Ser Thr Arg Lys Asp Ile His His Arg Phe Val Arg Asp Glu Ile Gln 
                805                 810                 815     


Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gly Ile Asn Lys Ala Asp 
            820                 825                 830         


Ile Arg Gln Val Ile His Tyr Gly Ala Pro Lys Asp Met Glu Ser Tyr 
        835                 840                 845             


Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Ser Ser Cys 
    850                 855                 860                 


His Val Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn Arg His Leu Leu 
865                 870                 875                 880 


Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Leu Lys Met Met 
                885                 890                 895     


Ala Lys Met Glu Lys Tyr Leu His Ser Ser Arg Cys Arg Arg Gln Ile 
            900                 905                 910         


Ile Leu Ser His Phe Glu Asp Lys Gln Val Gln Lys Ala Ser Leu Gly 
        915                 920                 925             


Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Ser Arg Leu Asp 
    930                 935                 940                 


His Cys Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Trp Asp Phe Gly 
945                 950                 955                 960 


Pro Gln Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Leu Gly Glu Lys 
                965                 970                 975     


Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Ser Asn Ser Gln 
            980                 985                 990         


Arg Leu Ala Asp Gln Tyr Arg Arg  His Ser Leu Phe Gly  Thr Gly Lys 
        995                 1000                 1005             


Asp Gln  Thr Glu Ser Trp Trp  Lys Ala Phe Ser Arg  Gln Leu Ile 
    1010                 1015                 1020             


Thr Glu  Gly Phe Leu Val Glu  Val Ser Arg Tyr Asn  Lys Phe Met 
    1025                 1030                 1035             


Lys Ile  Cys Ala Leu Thr Lys  Lys Gly Arg Asn Trp  Leu His Lys 
    1040                 1045                 1050             


Ala Asn  Thr Glu Ser Gln Ser  Leu Ile Leu Gln Ala  Asn Glu Glu 
    1055                 1060                 1065             


Leu Cys  Pro Lys Lys Leu Leu  Leu Pro Ser Ser Lys  Thr Val Ser 
    1070                 1075                 1080             


Ser Gly  Thr Lys Glu His Cys  Tyr Asn Gln Val Pro  Val Glu Leu 
    1085                 1090                 1095             


Ser Thr  Glu Lys Lys Ser Asn  Leu Glu Lys Leu Tyr  Ser Tyr Lys 
    1100                 1105                 1110             


Pro Cys  Asp Lys Ile Ser Ser  Gly Ser Asn Ile Ser  Lys Lys Ser 
    1115                 1120                 1125             


Ile Met  Val Gln Ser Pro Glu  Lys Ala Tyr Ser Ser  Ser Gln Pro 
    1130                 1135                 1140             


Val Ile  Ser Ala Gln Glu Gln  Glu Thr Gln Ile Val  Leu Tyr Gly 
    1145                 1150                 1155             


Lys Leu  Val Glu Ala Arg Gln  Lys His Ala Asn Lys  Met Asp Val 
    1160                 1165                 1170             


Pro Pro  Ala Ile Leu Ala Thr  Asn Lys Ile Leu Val  Asp Met Ala 
    1175                 1180                 1185             


Lys Met  Arg Pro Thr Thr Val  Glu Asn Val Lys Arg  Ile Asp Gly 
    1190                 1195                 1200             


Val Ser  Glu Gly Lys Ala Ala  Met Leu Ala Pro Leu  Leu Glu Val 
    1205                 1210                 1215             


Ile Lys  His Phe Cys Gln Thr  Asn Ser Val Gln Thr  Asp Leu Phe 
    1220                 1225                 1230             


Ser Ser  Thr Lys Pro Gln Glu  Glu Gln Lys Thr Ser  Leu Val Ala 
    1235                 1240                 1245             


Lys Asn  Lys Ile Cys Thr Leu  Ser Gln Ser Met Ala  Ile Thr Tyr 
    1250                 1255                 1260             


Ser Leu  Phe Gln Glu Lys Lys  Met Pro Leu Lys Ser  Ile Ala Glu 
    1265                 1270                 1275             


Ser Arg  Ile Leu Pro Leu Met  Thr Ile Gly Met His  Leu Ser Gln 
    1280                 1285                 1290             


Ala Val  Lys Ala Gly Cys Pro  Leu Asp Leu Glu Arg  Ala Gly Leu 
    1295                 1300                 1305             


Thr Pro  Glu Val Gln Lys Ile  Ile Ala Asp Val Ile  Arg Asn Pro 
    1310                 1315                 1320             


Pro Val  Asn Ser Asp Met Ser  Lys Ile Ser Leu Ile  Arg Met Leu 
    1325                 1330                 1335             


Val Pro  Glu Asn Ile Asp Thr  Tyr Leu Ile His Met  Ala Ile Glu 
    1340                 1345                 1350             


Ile Leu  Lys His Gly Pro Asp  Ser Gly Leu Gln Pro  Ser Cys Asp 
    1355                 1360                 1365             


Val Asn  Lys Arg Arg Cys Phe  Pro Gly Ser Glu Glu  Ile Cys Ser 
    1370                 1375                 1380             


Ser Ser  Lys Arg Ser Lys Glu  Glu Val Gly Ile Asn  Thr Glu Thr 
    1385                 1390                 1395             


Ser Ser  Ala Glu Arg Lys Arg  Arg Leu Pro Val Trp  Phe Ala Lys 
    1400                 1405                 1410             


Gly Ser  Asp Thr Ser Lys Lys  Leu Met Asp Lys Thr  Lys Arg Gly 
    1415                 1420                 1425             


Gly Leu  Phe Ser 
    1430         


<210>  11
<211>  4296
<212>  DNA
<213>  Homo sapiens

<400>  11
atgagtgaaa aaaaattgga aacaactgca cagcagcgga aatgtcctga atggatgaat       60

gtgcagaata aaagatgtgc tgtagaagaa agaaaggcat gtgttcggaa gagtgttttt      120

gaagatgacc tccccttctt agaattcact ggatccattg tgtatagtta cgatgctagt      180

gattgctctt tcctgtcaga agatattagc atgagtctat cagatgggga tgtggtggga      240

tttgacatgg agtggccacc attatacaat agagggaaac ttggcaaagt tgcactaatt      300

cagttgtgtg tttctgagag caaatgttac ttgttccacg tttcttccat gtcagttttt      360

ccccagggat taaaaatgtt gcttgaaaat aaagcagtta aaaaggcagg tgtaggaatt      420

gaaggagatc agtggaaact tctacgtgac tttgatatca aattgaagaa ttttgtggag      480

ttgacagatg ttgccaataa aaagctgaaa tgcacagaga cctggagcct taacagtctg      540

gttaaacacc tcttaggtaa acagctcctg aaagacaagt ctatccgctg tagcaattgg      600

agtaaatttc ctctcactga ggaccagaaa ctgtatgcag ccactgatgc ttatgctggt      660

tttattattt accgaaattt agagattttg gatgatactg tgcaaaggtt tgctataaat      720

aaagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa      780

gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg      840

gtttctatct tactaaagga tatttcagaa aatctatatt cactgaggag gatgataatt      900

gggtctacta acattgagac tgaactgagg cccagcaata atttaaactt attatccttt      960

gaagattcaa ctactggggg agtacaacag aaacaaatta gagaacatga agttttaatt     1020

cacgttgaag atgaaacatg ggacccaaca cttgatcatt tagctaaaca tgatggagaa     1080

gatgtacttg gaaataaagt ggaacgaaaa gaagatggat ttgaagatgg agtagaagac     1140

aacaaattga aagagaatat ggaaagagct tgtttgatgt cgttagatat tacagaacat     1200

gaactccaaa ttttggaaca gcagtctcag gaagaatatc ttagtgatat tgcttataaa     1260

tctactgagc atttatctcc caatgataat gaaaacgata cgtcctatgt aattgagagt     1320

gatgaagatt tagaaatgga gatgcttaag catttatctc ccaatgataa tgaaaacgat     1380

acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa gtctttagaa     1440

aacctcaata gtggcacggt agaaccaact cattctaaat gcttaaaaat ggaaagaaat     1500

ctgggtcttc ctactaaaga agaagaagaa gatgatgaaa atgaagctaa tgaaggggaa     1560

gaagatgatg ataaggactt tttgtggcca gcacccaatg aagagcaagt tacttgcctc     1620

aagatgtact ttggccattc cagttttaaa ccagttcagt ggaaagtgat tcattcagta     1680

ttagaagaaa gaagagataa tgttgctgtc atggcaactg gatatggaaa gagtttgtgc     1740

ttccagtatc cacctgttta tgtaggcaag attggccttg ttatctctcc ccttatttct     1800

ctgatggaag accaagtgct acagcttaaa atgtccaaca tcccagcttg cttccttgga     1860

tcagcacagt cagaaaatgt tctaacagat attaaattag gtaaataccg gattgtatac     1920

gtaactccag aatactgttc aggtaacatg ggcctgctcc agcaacttga ggctgatatt     1980

ggtatcacgc tcattgctgt ggatgaggct cactgtattt ctgagtgggg gcatgatttt     2040

agggattcat tcaggaagtt gggctcccta aagacagcac tgccaatggt tccaatcgtt     2100

gcacttactg ctactgcaag ttcttcaatc cgggaagaca ttgtacgttg cttaaatctg     2160

agaaatcctc agatcacctg tactggtttt gatcgaccaa acctgtattt agaagttagg     2220

cgaaaaacag ggaatatcct tcaggatctg cagccatttc ttgtcaaaac aagttcccac     2280

tgggaatttg aaggtccaac aatcatctac tgtccttcta gaaaaatgac acaacaagtt     2340

acaggtgaac ttaggaaact gaatctatcc tgtggaacat accatgcggg catgagtttt     2400

agcacaagga aagacattca tcataggttt gtaagagatg aaattcagtg tgtcatagct     2460

accatagctt ttggaatggg cattaataaa gctgacattc gccaagtcat tcattacggt     2520

gctcctaagg acatggaatc atattatcag gagattggta gagctggtcg tgatggactt     2580

caaagttctt gtcacgtcct ctgggctcct gcagacatta acttaaatag gcaccttctt     2640

actgagatac gtaatgagaa gtttcgatta tacaaattaa agatgatggc aaagatggaa     2700

aaatatcttc attctagcag atgtaggaga caaatcatct tgtctcattt tgaggacaaa     2760

caagtacaaa aagcctcctt gggaattatg ggaactgaaa aatgctgtga taattgcagg     2820

tccagattgg atcattgcta ttccatggat gactcagagg atacatcctg ggactttggt     2880

ccacaagcat ttaagctttt gtctgctgtg gacatcttag gcgaaaaatt tggaattggg     2940

cttccaattt tatttctccg aggatctaat tctcagcgtc ttgccgatca atatcgcagg     3000

cacagtttat ttggcactgg caaggatcaa acagagagtt ggtggaaggc tttttcccgt     3060

cagctgatca ctgagggatt cttggtagaa gtttctcggt ataacaaatt tatgaagatt     3120

tgcgccctta cgaaaaaggg tagaaattgg cttcataaag ctaatacaga atctcagagc     3180

ctcatccttc aagctaatga agaattgtgt ccaaagaagt tgcttctgcc tagttcgaaa     3240

actgtatctt cgggcaccaa agagcattgt tataatcaag taccagttga attaagtaca     3300

gagaagaagt ctaacttgga gaagttatat tcttataaac catgtgataa gatttcttct     3360

gggagtaaca tttctaaaaa aagtatcatg gtacagtcac cagaaaaagc ttacagttcc     3420

tcacagcctg ttatttcggc acaagagcag gagactcaga ttgtgttata tggcaaattg     3480

gtagaagcta ggcagaaaca tgccaataaa atggatgttc ccccagctat tctggcaaca     3540

aacaagatac tggtggatat ggccaaaatg agaccaacta cggttgaaaa cgtaaaaagg     3600

attgatggtg tttctgaagg caaagctgcc atgttggccc ctctgttgga agtcatcaaa     3660

catttctgcc aaacaaatag tgttcagaca gacctctttt caagtacaaa acctcaagaa     3720

gaacagaaga cgagtctggt agcaaaaaat aaaatatgca cactttcaca gtctatggcc     3780

atcacatact ctttattcca agaaaagaag atgcctttga agagcatagc tgagagcagg     3840

attctgcctc tcatgacaat tggcatgcac ttataccaag cggtgaaagc tggctgcccc     3900

cttgatttgg agcgagcagg cctgactcca gaggttcaga agattattgc tgatgttatc     3960

cgaaaccctc ccgtcaactc agatatgagt aaaattagcc taatcagaat gttagttcct     4020

gaaaacattg acacgtacct tatccacatg gcaattgaga tccttaaaca tggtcctgac     4080

agcggacttc aaccttcatg tgatgtcaac aaaaggagat gttttcccgg ttctgaagag     4140

atctgttcaa gttctaagag aagcaaggaa gaagtaggca tcaatactga gacttcatct     4200

gcagagagaa agagacgatt acctgtgtgg tttgccaaag gaagtgatac cagcaagaaa     4260

ttaatggaca aaacgaaaag gggaggtctt tttagt                               4296


<210>  12
<211>  1432
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gln Gln Arg Lys Cys Pro 
1               5                   10                  15      


Glu Trp Met Asn Val Gln Asn Lys Arg Cys Ala Val Glu Glu Arg Lys 
            20                  25                  30          


Ala Cys Val Arg Lys Ser Val Phe Glu Asp Asp Leu Pro Phe Leu Glu 
        35                  40                  45              


Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Ala Ser Asp Cys Ser Phe 
    50                  55                  60                  


Leu Ser Glu Asp Ile Ser Met Ser Leu Ser Asp Gly Asp Val Val Gly 
65                  70                  75                  80  


Phe Asp Met Glu Trp Pro Pro Leu Tyr Asn Arg Gly Lys Leu Gly Lys 
                85                  90                  95      


Val Ala Leu Ile Gln Leu Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe 
            100                 105                 110         


His Val Ser Ser Met Ser Val Phe Pro Gln Gly Leu Lys Met Leu Leu 
        115                 120                 125             


Glu Asn Lys Ala Val Lys Lys Ala Gly Val Gly Ile Glu Gly Asp Gln 
    130                 135                 140                 


Trp Lys Leu Leu Arg Asp Phe Asp Ile Lys Leu Lys Asn Phe Val Glu 
145                 150                 155                 160 


Leu Thr Asp Val Ala Asn Lys Lys Leu Lys Cys Thr Glu Thr Trp Ser 
                165                 170                 175     


Leu Asn Ser Leu Val Lys His Leu Leu Gly Lys Gln Leu Leu Lys Asp 
            180                 185                 190         


Lys Ser Ile Arg Cys Ser Asn Trp Ser Lys Phe Pro Leu Thr Glu Asp 
        195                 200                 205             


Gln Lys Leu Tyr Ala Ala Thr Asp Ala Tyr Ala Gly Phe Ile Ile Tyr 
    210                 215                 220                 


Arg Asn Leu Glu Ile Leu Asp Asp Thr Val Gln Arg Phe Ala Ile Asn 
225                 230                 235                 240 


Lys Glu Glu Glu Ile Leu Leu Ser Asp Met Asn Lys Gln Leu Thr Ser 
                245                 250                 255     


Ile Ser Glu Glu Val Met Asp Leu Ala Lys His Leu Pro His Ala Phe 
            260                 265                 270         


Ser Lys Leu Glu Asn Pro Arg Arg Val Ser Ile Leu Leu Lys Asp Ile 
        275                 280                 285             


Ser Glu Asn Leu Tyr Ser Leu Arg Arg Met Ile Ile Gly Ser Thr Asn 
    290                 295                 300                 


Ile Glu Thr Glu Leu Arg Pro Ser Asn Asn Leu Asn Leu Leu Ser Phe 
305                 310                 315                 320 


Glu Asp Ser Thr Thr Gly Gly Val Gln Gln Lys Gln Ile Arg Glu His 
                325                 330                 335     


Glu Val Leu Ile His Val Glu Asp Glu Thr Trp Asp Pro Thr Leu Asp 
            340                 345                 350         


His Leu Ala Lys His Asp Gly Glu Asp Val Leu Gly Asn Lys Val Glu 
        355                 360                 365             


Arg Lys Glu Asp Gly Phe Glu Asp Gly Val Glu Asp Asn Lys Leu Lys 
    370                 375                 380                 


Glu Asn Met Glu Arg Ala Cys Leu Met Ser Leu Asp Ile Thr Glu His 
385                 390                 395                 400 


Glu Leu Gln Ile Leu Glu Gln Gln Ser Gln Glu Glu Tyr Leu Ser Asp 
                405                 410                 415     


Ile Ala Tyr Lys Ser Thr Glu His Leu Ser Pro Asn Asp Asn Glu Asn 
            420                 425                 430         


Asp Thr Ser Tyr Val Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met 
        435                 440                 445             


Leu Lys His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val 
    450                 455                 460                 


Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys Ser Leu Glu 
465                 470                 475                 480 


Asn Leu Asn Ser Gly Thr Val Glu Pro Thr His Ser Lys Cys Leu Lys 
                485                 490                 495     


Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Glu Glu Asp Asp 
            500                 505                 510         


Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Lys Asp Phe Leu 
        515                 520                 525             


Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Lys Met Tyr Phe 
    530                 535                 540                 


Gly His Ser Ser Phe Lys Pro Val Gln Trp Lys Val Ile His Ser Val 
545                 550                 555                 560 


Leu Glu Glu Arg Arg Asp Asn Val Ala Val Met Ala Thr Gly Tyr Gly 
                565                 570                 575     


Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gly Lys Ile Gly 
            580                 585                 590         


Leu Val Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gln Val Leu Gln 
        595                 600                 605             


Leu Lys Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Ser Ala Gln Ser 
    610                 615                 620                 


Glu Asn Val Leu Thr Asp Ile Lys Leu Gly Lys Tyr Arg Ile Val Tyr 
625                 630                 635                 640 


Val Thr Pro Glu Tyr Cys Ser Gly Asn Met Gly Leu Leu Gln Gln Leu 
                645                 650                 655     


Glu Ala Asp Ile Gly Ile Thr Leu Ile Ala Val Asp Glu Ala His Cys 
            660                 665                 670         


Ile Ser Glu Trp Gly His Asp Phe Arg Asp Ser Phe Arg Lys Leu Gly 
        675                 680                 685             


Ser Leu Lys Thr Ala Leu Pro Met Val Pro Ile Val Ala Leu Thr Ala 
    690                 695                 700                 


Thr Ala Ser Ser Ser Ile Arg Glu Asp Ile Val Arg Cys Leu Asn Leu 
705                 710                 715                 720 


Arg Asn Pro Gln Ile Thr Cys Thr Gly Phe Asp Arg Pro Asn Leu Tyr 
                725                 730                 735     


Leu Glu Val Arg Arg Lys Thr Gly Asn Ile Leu Gln Asp Leu Gln Pro 
            740                 745                 750         


Phe Leu Val Lys Thr Ser Ser His Trp Glu Phe Glu Gly Pro Thr Ile 
        755                 760                 765             


Ile Tyr Cys Pro Ser Arg Lys Met Thr Gln Gln Val Thr Gly Glu Leu 
    770                 775                 780                 


Arg Lys Leu Asn Leu Ser Cys Gly Thr Tyr His Ala Gly Met Ser Phe 
785                 790                 795                 800 


Ser Thr Arg Lys Asp Ile His His Arg Phe Val Arg Asp Glu Ile Gln 
                805                 810                 815     


Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gly Ile Asn Lys Ala Asp 
            820                 825                 830         


Ile Arg Gln Val Ile His Tyr Gly Ala Pro Lys Asp Met Glu Ser Tyr 
        835                 840                 845             


Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Ser Ser Cys 
    850                 855                 860                 


His Val Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn Arg His Leu Leu 
865                 870                 875                 880 


Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Leu Lys Met Met 
                885                 890                 895     


Ala Lys Met Glu Lys Tyr Leu His Ser Ser Arg Cys Arg Arg Gln Ile 
            900                 905                 910         


Ile Leu Ser His Phe Glu Asp Lys Gln Val Gln Lys Ala Ser Leu Gly 
        915                 920                 925             


Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Ser Arg Leu Asp 
    930                 935                 940                 


His Cys Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Trp Asp Phe Gly 
945                 950                 955                 960 


Pro Gln Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Leu Gly Glu Lys 
                965                 970                 975     


Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Ser Asn Ser Gln 
            980                 985                 990         


Arg Leu Ala Asp Gln Tyr Arg Arg  His Ser Leu Phe Gly  Thr Gly Lys 
        995                 1000                 1005             


Asp Gln  Thr Glu Ser Trp Trp  Lys Ala Phe Ser Arg  Gln Leu Ile 
    1010                 1015                 1020             


Thr Glu  Gly Phe Leu Val Glu  Val Ser Arg Tyr Asn  Lys Phe Met 
    1025                 1030                 1035             


Lys Ile  Cys Ala Leu Thr Lys  Lys Gly Arg Asn Trp  Leu His Lys 
    1040                 1045                 1050             


Ala Asn  Thr Glu Ser Gln Ser  Leu Ile Leu Gln Ala  Asn Glu Glu 
    1055                 1060                 1065             


Leu Cys  Pro Lys Lys Leu Leu  Leu Pro Ser Ser Lys  Thr Val Ser 
    1070                 1075                 1080             


Ser Gly  Thr Lys Glu His Cys  Tyr Asn Gln Val Pro  Val Glu Leu 
    1085                 1090                 1095             


Ser Thr  Glu Lys Lys Ser Asn  Leu Glu Lys Leu Tyr  Ser Tyr Lys 
    1100                 1105                 1110             


Pro Cys  Asp Lys Ile Ser Ser  Gly Ser Asn Ile Ser  Lys Lys Ser 
    1115                 1120                 1125             


Ile Met  Val Gln Ser Pro Glu  Lys Ala Tyr Ser Ser  Ser Gln Pro 
    1130                 1135                 1140             


Val Ile  Ser Ala Gln Glu Gln  Glu Thr Gln Ile Val  Leu Tyr Gly 
    1145                 1150                 1155             


Lys Leu  Val Glu Ala Arg Gln  Lys His Ala Asn Lys  Met Asp Val 
    1160                 1165                 1170             


Pro Pro  Ala Ile Leu Ala Thr  Asn Lys Ile Leu Val  Asp Met Ala 
    1175                 1180                 1185             


Lys Met  Arg Pro Thr Thr Val  Glu Asn Val Lys Arg  Ile Asp Gly 
    1190                 1195                 1200             


Val Ser  Glu Gly Lys Ala Ala  Met Leu Ala Pro Leu  Leu Glu Val 
    1205                 1210                 1215             


Ile Lys  His Phe Cys Gln Thr  Asn Ser Val Gln Thr  Asp Leu Phe 
    1220                 1225                 1230             


Ser Ser  Thr Lys Pro Gln Glu  Glu Gln Lys Thr Ser  Leu Val Ala 
    1235                 1240                 1245             


Lys Asn  Lys Ile Cys Thr Leu  Ser Gln Ser Met Ala  Ile Thr Tyr 
    1250                 1255                 1260             


Ser Leu  Phe Gln Glu Lys Lys  Met Pro Leu Lys Ser  Ile Ala Glu 
    1265                 1270                 1275             


Ser Arg  Ile Leu Pro Leu Met  Thr Ile Gly Met His  Leu Tyr Gln 
    1280                 1285                 1290             


Ala Val  Lys Ala Gly Cys Pro  Leu Asp Leu Glu Arg  Ala Gly Leu 
    1295                 1300                 1305             


Thr Pro  Glu Val Gln Lys Ile  Ile Ala Asp Val Ile  Arg Asn Pro 
    1310                 1315                 1320             


Pro Val  Asn Ser Asp Met Ser  Lys Ile Ser Leu Ile  Arg Met Leu 
    1325                 1330                 1335             


Val Pro  Glu Asn Ile Asp Thr  Tyr Leu Ile His Met  Ala Ile Glu 
    1340                 1345                 1350             


Ile Leu  Lys His Gly Pro Asp  Ser Gly Leu Gln Pro  Ser Cys Asp 
    1355                 1360                 1365             


Val Asn  Lys Arg Arg Cys Phe  Pro Gly Ser Glu Glu  Ile Cys Ser 
    1370                 1375                 1380             


Ser Ser  Lys Arg Ser Lys Glu  Glu Val Gly Ile Asn  Thr Glu Thr 
    1385                 1390                 1395             


Ser Ser  Ala Glu Arg Lys Arg  Arg Leu Pro Val Trp  Phe Ala Lys 
    1400                 1405                 1410             


Gly Ser  Asp Thr Ser Lys Lys  Leu Met Asp Lys Thr  Lys Arg Gly 
    1415                 1420                 1425             


Gly Leu  Phe Ser 
    1430         


<210>  13
<211>  4296
<212>  DNA
<213>  Homo sapiens

<400>  13
atgagtgaaa aaaaattgga aacaactgca cagcagcgga aatgtcctga atggatgaat       60

gtgcagaata aaagatgtgc tgtagaagaa agaaaggcat gtgttcggaa gagtgttttt      120

gaagatgacc tccccttctt agaattcact ggatccattg tgtatagtta cgatgctagt      180

gattgctctt tcctgtcaga agatattagc atgagtctat cagatgggga tgtggtggga      240

tttgacatgg agtggccacc attatacaat agagggaaac ttggcaaagt tgcactaatt      300

cagttgtgtg tttctgagag caaatgttac ttgttccacg tttcttccat gtcagttttt      360

ccccagggat taaaaatgtt gcttgaaaat aaagcagtta aaaaggcagg tgtaggaatt      420

gaaggagatc agtggaaact tctacgtgac tttgatatca aattgaagaa ttttgtggag      480

ttgacagatg ttgccaataa aaagctgaaa tgcacagaga cctggagcct taacagtctg      540

gttaaacacc tcttaggtaa acagctcctg aaagacaagt ctatccgctg tagcaattgg      600

agtaaatttc ctctcactga ggaccagaaa ctgtatgcag ccactgatgc ttatgctggt      660

tttattattt accgaaattt agagattttg gatgatactg tgcaaaggtt tgctataaat      720

aaagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa      780

gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg      840

gtttctatct tactaaagga tatttcagaa aatctatatt cactgaggag gatgataatt      900

gggtctacta acattgagac tgaactgagg cccagcaata atttaaactt attatccttt      960

gaagattcaa ctactggggg agtacaacag aaacaaatta gagaacatga agttttaatt     1020

cacgttgaag atgaaacatg ggacccaaca cttgatcatt tagctaaaca tgatggagaa     1080

gatgtacttg gaaataaagt ggaacgaaaa gaagatggat ttgaagatgg agtagaagac     1140

aacaaattga aagagaatat ggaaagagct tgtttgatgt cgttagatat tacagaacat     1200

gaactccaaa ttttggaaca gcagtctcag gaagaatatc ttagtgatat tgcttataaa     1260

tctactgagc atttatctcc caatgataat gaaaacgata cgtcctatgt aattgagagt     1320

gatgaagatt tagaaatgga gatgcttaag catttatctc ccaatgataa tgaaaacgat     1380

acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa gtctttagaa     1440

aacctcaata gtggcacggt agaaccaact cattctaaat gcttaaaaat ggaaagaaat     1500

ctgggtcttc ctactaaaga agaagaagaa gatgatgaaa atgaagctaa tgaaggggaa     1560

gaagatgatg ataaggactt tttgtggcca gcacccaatg aagagcaagt tacttgcctc     1620

aagatgtact ttggccattc cagttttaaa ccagttcagt ggaaagtgat tcattcagta     1680

ttagaagaaa gaagagataa tgttgctgtc atggcaactg gatatggaaa gagtttgtgc     1740

ttccagtatc cacctgttta tgtaggcaag attggccttg ttatctctcc ccttatttct     1800

ctgatggaag accaagtgct acagcttaaa atgtccaaca tcccagcttg cttccttgga     1860

tcagcacagt cagaaaatgt tctaacagat attaaattag gtaaataccg gattgtatac     1920

gtaactccag aatactgttc aggtaacatg ggcctgctcc agcaacttga ggctgatatt     1980

ggtatcacgc tcattgctgt ggatgaggct cactgtattt ctgagtgggg gcatgatttt     2040

agggattcat tcaggaagtt gggctcccta aagacagcac tgccaatggt tccaatcgtt     2100

gcacttactg ctattgcaag ttcttcaatc cgggaagaca ttgtacgttg cttaaatctg     2160

agaaatcctc agatcacctg tactggtttt gatcgaccaa acctgtattt agaagttagg     2220

cgaaaaacag ggaatatcct tcaggatctg cagccatttc ttgtcaaaac aagttcccac     2280

tgggaatttg aaggtccaac aatcatctac tgtccttcta gaaaaatgac acaacaagtt     2340

acaggtgaac ttaggaaact gaatctatcc tgtggaacat accatgcggg catgagtttt     2400

agcacaagga aagacattca tcataggttt gtaagagatg aaattcagtg tgtcatagct     2460

accatagctt ttggaatggg cattaataaa gctgacattc gccaagtcat tcattacggt     2520

gctcctaagg acatggaatc atattatcag gagattggta gagctggtcg tgatggactt     2580

caaagttctt gtcacgtcct ctgggctcct gcagacatta acttaaatag gcaccttctt     2640

actgagatac gtaatgagaa gtttcgatta tacaaattaa agatgatggc aaagatggaa     2700

aaatatcttc attctagcag atgtaggaga caaatcatct tgtctcattt tgaggacaaa     2760

caagtacaaa aagcctcctt gggaattatg ggaactgaaa aatgctgtga taattgcagg     2820

tccagattgg atcattgcta ttccatggat gactcagagg atacatcctg ggactttggt     2880

ccacaagcat ttaagctttt gtctgctgtg gacatcttag gcgaaaaatt tggaattggg     2940

cttccaattt tatttctccg aggatctaat tctcagcgtc ttgccgatca atatcgcagg     3000

cacagtttat ttggcactgg caaggatcaa acagagagtt ggtggaaggc tttttcccgt     3060

cagctgatca ctgagggatt cttggtagaa gtttctcggt ataacaaatt tatgaagatt     3120

tgcgccctta cgaaaaaggg tagaaattgg cttcataaag ctaatacaga atctcagagc     3180

ctcatccttc aagctaatga agaattgtgt ccaaagaagt tgcttctgcc tagttcgaaa     3240

actgtatctt cgggcaccaa agagcattgt tataatcaag taccagttga attaagtaca     3300

gagaagaagt ctaacttgga gaagttatat tcttataaac catgtgataa gatttcttct     3360

gggagtaaca tttctaaaaa aagtatcatg gtacagtcac cagaaaaagc ttacagttcc     3420

tcacagcctg ttatttcggc acaagagcag gagactcaga ttgtgttata tggcaaattg     3480

gtagaagcta ggcagaaaca tgccaataaa atggatgttc ccccagctat tctggcaaca     3540

aacaagatac tggtggatat ggccaaaatg agaccaacta cggttgaaaa cgtaaaaagg     3600

attgatggtg tttctgaagg caaagctgcc atgttggccc ctctgttgga agtcatcaaa     3660

catttctgcc aaacaaatag tgttcagaca gacctctttt caagtacaaa acctcaagaa     3720

gaacagaaga cgagtctggt agcaaaaaat aaaatatgca cactttcaca gtctatggcc     3780

atcacatact ctttattcca agaaaagaag atgcctttga agagcatagc tgagagcagg     3840

attctgcctc tcatgacaat tggcatgcac ttataccaag cggtgaaagc tggctgcccc     3900

cttgatttgg agcgagcagg cctgactcca gaggttcaga agattattgc tgatgttatc     3960

cgaaaccctc ccgtcaactc agatatgagt aaaattagcc taatcagaat gttagttcct     4020

gaaaacattg acacgtacct tatccacatg gcaattgaga tccttaaaca tggtcctgac     4080

agcggacttc aaccttcatg tgatgtcaac aaaaggagat gttttcccgg ttctgaagag     4140

atctgttcaa gttctaagag aagcaaggaa gaagtaggca tcaatactga gacttcatct     4200

gcagagagaa agagacgatt acctgtgtgg tttgccaaag gaagtgatac cagcaagaaa     4260

ttaatggaca aaacgaaaag gggaggtctt tttagt                               4296


<210>  14
<211>  1432
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gln Gln Arg Lys Cys Pro 
1               5                   10                  15      


Glu Trp Met Asn Val Gln Asn Lys Arg Cys Ala Val Glu Glu Arg Lys 
            20                  25                  30          


Ala Cys Val Arg Lys Ser Val Phe Glu Asp Asp Leu Pro Phe Leu Glu 
        35                  40                  45              


Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Ala Ser Asp Cys Ser Phe 
    50                  55                  60                  


Leu Ser Glu Asp Ile Ser Met Ser Leu Ser Asp Gly Asp Val Val Gly 
65                  70                  75                  80  


Phe Asp Met Glu Trp Pro Pro Leu Tyr Asn Arg Gly Lys Leu Gly Lys 
                85                  90                  95      


Val Ala Leu Ile Gln Leu Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe 
            100                 105                 110         


His Val Ser Ser Met Ser Val Phe Pro Gln Gly Leu Lys Met Leu Leu 
        115                 120                 125             


Glu Asn Lys Ala Val Lys Lys Ala Gly Val Gly Ile Glu Gly Asp Gln 
    130                 135                 140                 


Trp Lys Leu Leu Arg Asp Phe Asp Ile Lys Leu Lys Asn Phe Val Glu 
145                 150                 155                 160 


Leu Thr Asp Val Ala Asn Lys Lys Leu Lys Cys Thr Glu Thr Trp Ser 
                165                 170                 175     


Leu Asn Ser Leu Val Lys His Leu Leu Gly Lys Gln Leu Leu Lys Asp 
            180                 185                 190         


Lys Ser Ile Arg Cys Ser Asn Trp Ser Lys Phe Pro Leu Thr Glu Asp 
        195                 200                 205             


Gln Lys Leu Tyr Ala Ala Thr Asp Ala Tyr Ala Gly Phe Ile Ile Tyr 
    210                 215                 220                 


Arg Asn Leu Glu Ile Leu Asp Asp Thr Val Gln Arg Phe Ala Ile Asn 
225                 230                 235                 240 


Lys Glu Glu Glu Ile Leu Leu Ser Asp Met Asn Lys Gln Leu Thr Ser 
                245                 250                 255     


Ile Ser Glu Glu Val Met Asp Leu Ala Lys His Leu Pro His Ala Phe 
            260                 265                 270         


Ser Lys Leu Glu Asn Pro Arg Arg Val Ser Ile Leu Leu Lys Asp Ile 
        275                 280                 285             


Ser Glu Asn Leu Tyr Ser Leu Arg Arg Met Ile Ile Gly Ser Thr Asn 
    290                 295                 300                 


Ile Glu Thr Glu Leu Arg Pro Ser Asn Asn Leu Asn Leu Leu Ser Phe 
305                 310                 315                 320 


Glu Asp Ser Thr Thr Gly Gly Val Gln Gln Lys Gln Ile Arg Glu His 
                325                 330                 335     


Glu Val Leu Ile His Val Glu Asp Glu Thr Trp Asp Pro Thr Leu Asp 
            340                 345                 350         


His Leu Ala Lys His Asp Gly Glu Asp Val Leu Gly Asn Lys Val Glu 
        355                 360                 365             


Arg Lys Glu Asp Gly Phe Glu Asp Gly Val Glu Asp Asn Lys Leu Lys 
    370                 375                 380                 


Glu Asn Met Glu Arg Ala Cys Leu Met Ser Leu Asp Ile Thr Glu His 
385                 390                 395                 400 


Glu Leu Gln Ile Leu Glu Gln Gln Ser Gln Glu Glu Tyr Leu Ser Asp 
                405                 410                 415     


Ile Ala Tyr Lys Ser Thr Glu His Leu Ser Pro Asn Asp Asn Glu Asn 
            420                 425                 430         


Asp Thr Ser Tyr Val Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met 
        435                 440                 445             


Leu Lys His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val 
    450                 455                 460                 


Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys Ser Leu Glu 
465                 470                 475                 480 


Asn Leu Asn Ser Gly Thr Val Glu Pro Thr His Ser Lys Cys Leu Lys 
                485                 490                 495     


Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Glu Glu Asp Asp 
            500                 505                 510         


Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Lys Asp Phe Leu 
        515                 520                 525             


Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Lys Met Tyr Phe 
    530                 535                 540                 


Gly His Ser Ser Phe Lys Pro Val Gln Trp Lys Val Ile His Ser Val 
545                 550                 555                 560 


Leu Glu Glu Arg Arg Asp Asn Val Ala Val Met Ala Thr Gly Tyr Gly 
                565                 570                 575     


Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gly Lys Ile Gly 
            580                 585                 590         


Leu Val Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gln Val Leu Gln 
        595                 600                 605             


Leu Lys Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Ser Ala Gln Ser 
    610                 615                 620                 


Glu Asn Val Leu Thr Asp Ile Lys Leu Gly Lys Tyr Arg Ile Val Tyr 
625                 630                 635                 640 


Val Thr Pro Glu Tyr Cys Ser Gly Asn Met Gly Leu Leu Gln Gln Leu 
                645                 650                 655     


Glu Ala Asp Ile Gly Ile Thr Leu Ile Ala Val Asp Glu Ala His Cys 
            660                 665                 670         


Ile Ser Glu Trp Gly His Asp Phe Arg Asp Ser Phe Arg Lys Leu Gly 
        675                 680                 685             


Ser Leu Lys Thr Ala Leu Pro Met Val Pro Ile Val Ala Leu Thr Ala 
    690                 695                 700                 


Ile Ala Ser Ser Ser Ile Arg Glu Asp Ile Val Arg Cys Leu Asn Leu 
705                 710                 715                 720 


Arg Asn Pro Gln Ile Thr Cys Thr Gly Phe Asp Arg Pro Asn Leu Tyr 
                725                 730                 735     


Leu Glu Val Arg Arg Lys Thr Gly Asn Ile Leu Gln Asp Leu Gln Pro 
            740                 745                 750         


Phe Leu Val Lys Thr Ser Ser His Trp Glu Phe Glu Gly Pro Thr Ile 
        755                 760                 765             


Ile Tyr Cys Pro Ser Arg Lys Met Thr Gln Gln Val Thr Gly Glu Leu 
    770                 775                 780                 


Arg Lys Leu Asn Leu Ser Cys Gly Thr Tyr His Ala Gly Met Ser Phe 
785                 790                 795                 800 


Ser Thr Arg Lys Asp Ile His His Arg Phe Val Arg Asp Glu Ile Gln 
                805                 810                 815     


Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gly Ile Asn Lys Ala Asp 
            820                 825                 830         


Ile Arg Gln Val Ile His Tyr Gly Ala Pro Lys Asp Met Glu Ser Tyr 
        835                 840                 845             


Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Ser Ser Cys 
    850                 855                 860                 


His Val Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn Arg His Leu Leu 
865                 870                 875                 880 


Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Leu Lys Met Met 
                885                 890                 895     


Ala Lys Met Glu Lys Tyr Leu His Ser Ser Arg Cys Arg Arg Gln Ile 
            900                 905                 910         


Ile Leu Ser His Phe Glu Asp Lys Gln Val Gln Lys Ala Ser Leu Gly 
        915                 920                 925             


Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Ser Arg Leu Asp 
    930                 935                 940                 


His Cys Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Trp Asp Phe Gly 
945                 950                 955                 960 


Pro Gln Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Leu Gly Glu Lys 
                965                 970                 975     


Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Ser Asn Ser Gln 
            980                 985                 990         


Arg Leu Ala Asp Gln Tyr Arg Arg  His Ser Leu Phe Gly  Thr Gly Lys 
        995                 1000                 1005             


Asp Gln  Thr Glu Ser Trp Trp  Lys Ala Phe Ser Arg  Gln Leu Ile 
    1010                 1015                 1020             


Thr Glu  Gly Phe Leu Val Glu  Val Ser Arg Tyr Asn  Lys Phe Met 
    1025                 1030                 1035             


Lys Ile  Cys Ala Leu Thr Lys  Lys Gly Arg Asn Trp  Leu His Lys 
    1040                 1045                 1050             


Ala Asn  Thr Glu Ser Gln Ser  Leu Ile Leu Gln Ala  Asn Glu Glu 
    1055                 1060                 1065             


Leu Cys  Pro Lys Lys Leu Leu  Leu Pro Ser Ser Lys  Thr Val Ser 
    1070                 1075                 1080             


Ser Gly  Thr Lys Glu His Cys  Tyr Asn Gln Val Pro  Val Glu Leu 
    1085                 1090                 1095             


Ser Thr  Glu Lys Lys Ser Asn  Leu Glu Lys Leu Tyr  Ser Tyr Lys 
    1100                 1105                 1110             


Pro Cys  Asp Lys Ile Ser Ser  Gly Ser Asn Ile Ser  Lys Lys Ser 
    1115                 1120                 1125             


Ile Met  Val Gln Ser Pro Glu  Lys Ala Tyr Ser Ser  Ser Gln Pro 
    1130                 1135                 1140             


Val Ile  Ser Ala Gln Glu Gln  Glu Thr Gln Ile Val  Leu Tyr Gly 
    1145                 1150                 1155             


Lys Leu  Val Glu Ala Arg Gln  Lys His Ala Asn Lys  Met Asp Val 
    1160                 1165                 1170             


Pro Pro  Ala Ile Leu Ala Thr  Asn Lys Ile Leu Val  Asp Met Ala 
    1175                 1180                 1185             


Lys Met  Arg Pro Thr Thr Val  Glu Asn Val Lys Arg  Ile Asp Gly 
    1190                 1195                 1200             


Val Ser  Glu Gly Lys Ala Ala  Met Leu Ala Pro Leu  Leu Glu Val 
    1205                 1210                 1215             


Ile Lys  His Phe Cys Gln Thr  Asn Ser Val Gln Thr  Asp Leu Phe 
    1220                 1225                 1230             


Ser Ser  Thr Lys Pro Gln Glu  Glu Gln Lys Thr Ser  Leu Val Ala 
    1235                 1240                 1245             


Lys Asn  Lys Ile Cys Thr Leu  Ser Gln Ser Met Ala  Ile Thr Tyr 
    1250                 1255                 1260             


Ser Leu  Phe Gln Glu Lys Lys  Met Pro Leu Lys Ser  Ile Ala Glu 
    1265                 1270                 1275             


Ser Arg  Ile Leu Pro Leu Met  Thr Ile Gly Met His  Leu Tyr Gln 
    1280                 1285                 1290             


Ala Val  Lys Ala Gly Cys Pro  Leu Asp Leu Glu Arg  Ala Gly Leu 
    1295                 1300                 1305             


Thr Pro  Glu Val Gln Lys Ile  Ile Ala Asp Val Ile  Arg Asn Pro 
    1310                 1315                 1320             


Pro Val  Asn Ser Asp Met Ser  Lys Ile Ser Leu Ile  Arg Met Leu 
    1325                 1330                 1335             


Val Pro  Glu Asn Ile Asp Thr  Tyr Leu Ile His Met  Ala Ile Glu 
    1340                 1345                 1350             


Ile Leu  Lys His Gly Pro Asp  Ser Gly Leu Gln Pro  Ser Cys Asp 
    1355                 1360                 1365             


Val Asn  Lys Arg Arg Cys Phe  Pro Gly Ser Glu Glu  Ile Cys Ser 
    1370                 1375                 1380             


Ser Ser  Lys Arg Ser Lys Glu  Glu Val Gly Ile Asn  Thr Glu Thr 
    1385                 1390                 1395             


Ser Ser  Ala Glu Arg Lys Arg  Arg Leu Pro Val Trp  Phe Ala Lys 
    1400                 1405                 1410             


Gly Ser  Asp Thr Ser Lys Lys  Leu Met Asp Lys Thr  Lys Arg Gly 
    1415                 1420                 1425             


Gly Leu  Phe Ser 
    1430         


<210>  15
<211>  3396
<212>  DNA
<213>  Homo sapiens

<400>  15
atgccgcgcg ctccccgctg ccgagccgtg cgctccctgc tgcgcagcca ctaccgcgag       60

gtgctgccgc tggccacgtt cgtgcggcgc ctggggcccc agggctggcg gctggtgcag      120

cgcggggacc cggcggcttt ccgcgcgctg gtggcccagt gcctggtgtg cgtgccctgg      180

gacgcacggc cgccccccgc cgccccctcc ttccgccagg tgtcctgcct gaaggagctg      240

gtggcccgag tgctgcagag gctgtgcgag cgcggcgcga agaacgtgct ggccttcggc      300

ttcgcgctgc tggacggggc ccgcgggggc ccccccgagg ccttcaccac cagcgtgcgc      360

agctacctgc ccaacacggt gaccgacgca ctgcggggga gcggggcgtg ggggctgctg      420

ctgcgccgcg tgggcgacga cgtgctggtt cacctgctgg cacgctgcgc gctctttgtg      480

ctggtggctc ccagctgcgc ctaccaggtg tgcgggccgc cgctgtacca gctcggcgct      540

gccactcagg cccggccccc gccacacgct agtggacccc gaaggcgtct gcgatgcgaa      600

cgggcctgga accatagcgt cagggaggcc ggggtccccc tgggcctgcc agccccgggt      660

gcgaggaggc gcgggggcag tgccagccga agtctgccgt tgcccaagag gcccaggcgt      720

ggcgctgccc ctgagccgga gcggacgccc gttgggcagg ggtcctgggc ccacccgggc      780

aggacgcgtg gaccgagtga ccgtggtttc tgtgtggtgt cacctgccag acccgccgaa      840

gaagccacct ctttggaggg tgcgctctct ggcacgcgcc actcccaccc atccgtgggc      900

cgccagcacc acgcgggccc cccatccaca tcgcggccac cacgtccctg ggacacgcct      960

tgtcccccgg tgtacgccga gaccaagcac ttcctctact cctcaggcga caaggagcag     1020

ctgcggccct ccttcctact cagctctctg aggcccagcc tgactggcgc tcggaggctc     1080

gtggagacca tctttctggg ttccaggccc tggatgccag ggactccccg caggttgccc     1140

cgcctgcccc agcgctactg gcaaatgcgg cccctgtttc tggagctgct tgggaaccac     1200

gcgcagtgcc cctacggggt gctcctcaag acgcactgcc cgctgcgagc tgcggtcacc     1260

ccagcagccg gtgtctgtgc ccgggagaag ccccagggct ctgtggcggc ccccgaggag     1320

gaggacacag acccccgtcg cctggtgcag ctgctccgcc agcacagcag cccctggcag     1380

gtgtacggct tcgtgcgggc ctgcctgcgc cggctggtgc ccccaggcct ctggggctcc     1440

aggcacaacg aacgccgctt cctcaggaac accaagaagt tcatctccct ggggaagcat     1500

gccaagctct cgctgcagga gctgacgtgg aagatgagcg tgcgggactg cgcttggctg     1560

cgcaggagcc caggggttgg ctgtgttccg gccgcagagc accgtctgcg tgaggagatc     1620

ctggccaagt tcctgcactg gctgatgagt gtgtacgtcg tcgagctgct caggtctttc     1680

ttttatgtca cggagaccac gtttcaaaag aacaggctct ttttctaccg gaagagtgtc     1740

tggagcaagt tgcaaagcat tggaatcaga cagcacttga agagggtgca gctgcgggag     1800

ctgtcggaag cagaggtcag gcagcatcgg gaagccaggc ccgccctgct gacgtccaga     1860

ctccgcttca tccccaagcc tgacgggctg cggccgattg tgaacatgga ctacgtcgtg     1920

ggagccagaa cgttccgcag agaaaagagg gccgagcgtc tcacctcgag ggtgaaggca     1980

ctgttcagcg tgctcaacta cgagcgggcg cggcgccccg gcctcctggg cgcctctgtg     2040

ctgggcctgg acgatatcca cagggcctgg cgcaccttcg tgctgcgtgt gcgggcccag     2100

gacccgccgc ctgagctgta ctttgtcaag gtggatgtga cgggcgcgta cgacaccatc     2160

ccccaggaca ggctcacgga ggtcatcgcc agcatcatca aaccccagaa cacgtactgc     2220

gtgcgtcggt atgccgtggt ccagaaggcc gcccatgggc acgtccgcaa ggccttcaag     2280

agccacgtct ctaccttgac agacctccag ccgtacatgc gacagttcgt ggctcacctg     2340

caggagacca gcccgctgag ggatgccgtc gtcatcgagc agagctcctc cctgaatgag     2400

gccagcagtg gcctcttcga cgtcttccta cgcttcatgt gccaccacgc cgtgcgcatc     2460

aggggcaagt cctacgtcca gtgccagggg atcccgcagg gctccatcct ctccacgctg     2520

ctctgcagcc tgtgctacgg cgacatggag aacaagctgt ttgcggggat tcggcgggac     2580

gggctgctcc tgcgtttggt ggatgatttc ttgttggtga cacctcacct cacccacgcg     2640

aaaaccttcc tcaggaccct ggtccgaggt gtccctgagt atggctgcgt ggtgaacttg     2700

cggaagacag tggtgaactt ccctgtagaa gacgaggccc tgggtggcac ggcttttgtt     2760

cagatgccgg cccacggcct attcccctgg tgcggcctgc tgctggatac ccggaccctg     2820

gaggtgcaga gcgactactc cagctatgcc cggacctcca tcagagccag tctcaccttc     2880

aaccgcggct tcaaggctgg gaggaacatg cgtcgcaaac tctttggggt cttgcggctg     2940

aagtgtcaca gcctgtttct ggatttgcag gtgaacagcc tccagacggt gtgcaccaac     3000

atctacaaga tcctcctgct gcaggcgtac aggtttcacg catgtgtgct gcagctccca     3060

tttcatcagc aagtttggaa gaaccccaca tttttcctgc gcgtcatctc tgacacggcc     3120

tccctctgct actccatcct gaaagccaag aacgcaggga tgtcgctggg ggccaagggc     3180

gccgccggcc ctctgccctc cgaggccgtg cagtggctgt gccaccaagc attcctgctc     3240

aagctgactc gacaccgtgt cacctacgtg ccactcctgg ggtcactcag gacagcccag     3300

acgcagctga gtcggaagct cccggggacg acgctgactg ccctggaggc cgcagccaac     3360

ccggcactgc cctcagactt caagaccatc ctggac                               3396


<210>  16
<211>  3396
<212>  DNA
<213>  Homo sapiens

<400>  16
atgccgcgcg ctccccgctg ccgagccgtg cgctccctgc tgcgcagcca ctaccgcgag       60

gtgctgccgc tggccacgtt cgtgcggcgc ctggggcccc agggctggcg gctggtgcag      120

cgcggggacc cggcggcttt ccgcgcgctg gtggcccagt gcctggtgtg cgtgccctgg      180

gacgcacggc cgccccccgc cgccccctcc ttccgccagg tgtcctgcct gaaggagctg      240

gtggcccgag tgctgcagag gctgtgcgag cgcggcgcga agaacgtgct ggccttcggc      300

ttcgcgctgc tggacggggc ccgcgggggc ccccccgagg ccttcaccac cagcgtgcgc      360

agctacctgc ccaacacggt gaccgacgca ctgcggggga gcggggcgtg ggggctgctg      420

ctgcgccgcg tgggcgacga cgtgctggtt cacctgctgg cacgctgcgc gctctttgtg      480

ctggtggctc ccagctgcgc ctaccaggtg tgcgggccgc cgctgtacca gctcggcgct      540

gccactcagg cccggccccc gccacacgct agtggacccc gaaggcgtct gggatgcgaa      600

cgggcctgga accatagcgt cagggaggcc ggggtccccc tgggcctgcc agccccgggt      660

gcgaggaggc gcgggggcag tgccagccga agtctgccgt tgcccaagag gcccaggcgt      720

ggcgctgccc ctgagccgga gcggacgccc gttgggcagg ggtcctgggc ccacccgggc      780

aggacgcgtg gaccgagtga ccgtggtttc tgtgtggtgt cacctgccag acccgccgaa      840

gaagccacct ctttggaggg tgcgctctct ggcacgcgcc actcccaccc atccgtgggc      900

cgccagcacc acgcgggccc cccatccaca tcgcggccac cacgtccctg ggacacgcct      960

tgtcccccgg tgtacgccga gaccaagcac ttcctctact cctcaggcga caaggagcag     1020

ctgcggccct ccttcctact cagctctctg aggcccagcc tgactggcgc tcggaggctc     1080

gtggagacca tctttctggg ttccaggccc tggatgccag ggactccccg caggttgccc     1140

cgcctgcccc agcgctactg gcaaatgcgg cccctgtttc tggagctgct tgggaaccac     1200

gcgcagtgcc cctacggggt gctcctcaag acgcactgcc cgctgcgagc tgcggtcacc     1260

ccagcagccg gtgtctgtgc ccgggagaag ccccagggct ctgtggcggc ccccgaggag     1320

gaggacacag acccccgtcg cctggtgcag ctgctccgcc agcacagcag cccctggcag     1380

gtgtacggct tcgtgcgggc ctgcctgcgc cggctggtgc ccccaggcct ctggggctcc     1440

aggcacaacg aacgccgctt cctcaggaac accaagaagt tcatctccct ggggaagcat     1500

gccaagctct cgctgcagga gctgacgtgg aagatgagcg tgcgggactg cgcttggctg     1560

cgcaggagcc caggggttgg ctgtgttccg gccgcagagc accgtctgcg tgaggagatc     1620

ctggccaagt tcctgcactg gctgatgagt gtgtacgtcg tcgagctgct caggtctttc     1680

ttttatgtca cggagaccac gtttcaaaag aacaggctct ttttctaccg gaagagtgtc     1740

tggagcaagt tgcaaagcat tggaatcaga cagcacttga agagggtgca gctgcgggag     1800

ctgtcggaag cagaggtcag gcagcatcgg gaagccaggc ccgccctgct gacgtccaga     1860

ctccgcttca tccccaagcc tgacgggctg cggccgattg tgaacatgga ctacgtcgtg     1920

ggagccagaa cgttccgcag agaaaagagg gccgagcgtc tcacctcgag ggtgaaggca     1980

ctgttcagcg tgctcaacta cgagcgggcg cggcgccccg gcctcctggg cgcctctgtg     2040

ctgggcctgg acgatatcca cagggcctgg cgcaccttcg tgctgcgtgt gcgggcccag     2100

gacccgccgc ctgagctgta ctttgtcaag gtggatgtga cgggcgcgta cgacaccatc     2160

ccccaggaca ggctcacgga ggtcatcgcc agcatcatca aaccccagaa cacgtactgc     2220

gtgcgtcggt atgccgtggt ccagaaggcc gcccatgggc acgtccgcaa ggccttcaag     2280

agccacgtct ctaccttgac agacctccag ccgtacatgc gacagttcgt ggctcacctg     2340

caggagacca gcccgctgag ggatgccgtc gtcatcgagc agagctcctc cctgaatgag     2400

gccagcagtg gcctcttcga cgtcttccta cgcttcatgt gccaccacgc cgtgcgcatc     2460

aggggcaagt cctacgtcca gtgccagggg atcccgcagg gctccatcct ctccacgctg     2520

ctctgcagcc tgtgctacgg cgacatggag aacaagctgt ttgcggggat tcggcgggac     2580

gggctgctcc tgcgtttggt ggatgatttc ttgttggtga cacctcacct cacccacgcg     2640

aaaaccttcc tcaggaccct ggtccgaggt gtccctgagt atggctgcgt ggtgaacttg     2700

cggaagacag tggtgaactt ccctgtagaa gacgaggccc tgggtggcac ggcttttgtt     2760

cagatgccgg cccacggcct attcccctgg tgcggcctgc tgctggatac ccggaccctg     2820

gaggtgcaga gcgactactc cagctatgcc cggacctcca tcagagccag tctcaccttc     2880

aaccgcggct tcaaggctgg gaggaacatg cgtcgcaaac tctttggggt cttgcggctg     2940

aagtgtcaca gcctgtttct ggatttgcag gtgaacagcc tccagacggt gtgcaccaac     3000

atctacaaga tcctcctgct gcaggcgtac aggtttcacg catgtgtgct gcagctccca     3060

tttcatcagc aagtttggaa gaaccccaca tttttcctgc gcgtcatctc tgacacggcc     3120

tccctctgct actccatcct gaaagccaag aacgcaggga tgtcgctggg ggccaagggc     3180

gccgccggcc ctctgccctc cgaggccgtg cagtggctgt gccaccaagc attcctgctc     3240

aagctgactc gacaccgtgt cacctacgtg ccactcctgg ggtcactcag gacagcccag     3300

acgcagctga gtcggaagct cccggggacg acgctgactg ccctggaggc cgcagccaac     3360

ccggcactgc cctcagactt caagaccatc ctggac                               3396


<210>  17
<211>  4018
<212>  DNA
<213>  Homo sapiens

<400>  17
caggcagcgc tgcgtcctgc tgcgcacgtg ggaagccctg gccccggcca cccccgcgat       60

gccgcgcgct ccccgctgcc gagccgtgcg ctccctgctg cgcagccact accgcgaggt      120

gctgccgctg gccacgttcg tgcggcgcct ggggccccag ggctggcggc tggtgcagcg      180

cggggacccg gcggctttcc gcgcgctggt ggcccagtgc ctggtgtgcg tgccctggga      240

cgcacggccg ccccccgccg ccccctcctt ccgccaggtg tcctgcctga aggagctggt      300

ggcccgagtg ctgcagaggc tgtgcgagcg cggcgcgaag aacgtgctgg ccttcggctt      360

cgcgctgctg gacggggccc gcgggggccc ccccgaggcc ttcaccacca gcgtgcgcag      420

ctacctgccc aacacggtga ccgacgcact gcgggggagc ggggcgtggg ggctgctgct      480

gcgccgcgtg ggcgacgacg tgctggttca cctgctggca cgctgcgcgc tctttgtgct      540

ggtggctccc agctgcgcct accaggtgtg cgggccgccg ctgtaccagc tcggcgctgc      600

cactcaggcc cggcccccgc cacacgctag tggaccccga aggcgtctgg gatgcgaacg      660

ggcctggaac catagcgtca gggaggccgg ggtccccctg ggcctgccag ccccgggtgc      720

gaggaggcgc gggggcagtg ccagccgaag tctgccgttg cccaagaggc ccaggcgtgg      780

cgctgcccct gagccggagc ggacgcccgt tgggcagggg tcctgggccc acccgggcag      840

gacgcgtgga ccgagtgacc gtggtttctg tgtggtgtca cctgccagac ccgccgaaga      900

agccacctct ttggagggtg cgctctctgg cacgcgccac tcccacccat ccgtgggccg      960

ccagcaccac gcgggccccc catccacatc gcggccacca cgtccctggg acacgccttg     1020

tcccccggtg tacgccgaga ccaagcactt cctctactcc tcaggcgaca aggagcagct     1080

gcggccctcc ttcctactca gctctctgag gcccagcctg actggcgctc ggaggctcgt     1140

ggagaccatc tttctgggtt ccaggccctg gatgccaggg actccccgca ggttgccccg     1200

cctgccccag cgctactggc aaatgcggcc cctgtttctg gagctgcttg ggaaccacgc     1260

gcagtgcccc tacggggtgc tcctcaagac gcactgcccg ctgcgagctg cggtcacccc     1320

agcagccggt gtctgtgccc gggagaagcc ccagggctct gtggcggccc ccgaggagga     1380

ggacacagac ccccgtcgcc tggtgcagct gctccgccag cacagcagcc cctggcaggt     1440

gtacggcttc gtgcgggcct gcctgcgccg gctggtgccc ccaggcctct ggggctccag     1500

gcacaacgaa cgccgcttcc tcaggaacac caagaagttc atctccctgg ggaagcatgc     1560

caagctctcg ctgcaggagc tgacgtggaa gatgagcgtg cgggactgcg cttggctgcg     1620

caggagccca ggggttggct gtgttccggc cgcagagcac cgtctgcgtg aggagatcct     1680

ggccaagttc ctgcactggc tgatgagtgt gtacgtcgtc gagctgctca ggtctttctt     1740

ttatgtcacg gagaccacgt ttcaaaagaa caggctcttt ttctaccgga agagtgtctg     1800

gagcaagttg caaagcattg gaatcagaca gcacttgaag agggtgcagc tgcgggagct     1860

gtcggaagca gaggtcaggc agcatcggga agccaggccc gccctgctga cgtccagact     1920

ccgcttcatc cccaagcctg acgggctgcg gccgattgtg aacatggact acgtcgtggg     1980

agccagaacg ttccgcagag aaaagagggc cgagcgtctc acctcgaggg tgaaggcact     2040

gttcagcgtg ctcaactacg agcgggcgcg gcgccccggc ctcctgggcg cctctgtgct     2100

gggcctggac gatatccaca gggcctggcg caccttcgtg ctgcgtgtgc gggcccagga     2160

cccgccgcct gagctgtact ttgtcaaggt ggatgtgacg ggcgcgtacg acaccatccc     2220

ccaggacagg ctcacggagg tcatcgccag catcatcaaa ccccagaaca cgtactgcgt     2280

gcgtcggtat gccgtggtcc agaaggccgc ccatgggcac gtccgcaagg ccttcaagag     2340

ccacgtctct accttgacag acctccagcc gtacatgcga cagttcgtgg ctcacctgca     2400

ggagaccagc ccgctgaggg atgccgtcgt catcgagcag agctcctccc tgaatgaggc     2460

cagcagtggc ctcttcgacg tcttcctacg cttcatgtgc caccacgccg tgcgcatcag     2520

gggcaagtcc tacgtccagt gccaggggat cccgcagggc tccatcctct ccacgctgct     2580

ctgcagcctg tgctacggcg acatggagaa caagctgttt gcggggattc ggcgggacgg     2640

gctgctcctg cgtttggtgg atgatttctt gttggtgaca cctcacctca cccacgcgaa     2700

aaccttcctc aggaccctgg tccgaggtgt ccctgagtat ggctgcgtgg tgaacttgcg     2760

gaagacagtg gtgaacttcc ctgtagaaga cgaggccctg ggtggcacgg cttttgttca     2820

gatgccggcc cacggcctat tcccctggtg cggcctgctg ctggataccc ggaccctgga     2880

ggtgcagagc gactactcca gctatgcccg gacctccatc agagccagtc tcaccttcaa     2940

ccgcggcttc aaggctggga ggaacatgcg tcgcaaactc tttggggtct tgcggctgaa     3000

gtgtcacagc ctgtttctgg atttgcaggt gaacagcctc cagacggtgt gcaccaacat     3060

ctacaagatc ctcctgctgc aggcgtacag gtttcacgca tgtgtgctgc agctcccatt     3120

tcatcagcaa gtttggaaga accccacatt tttcctgcgc gtcatctctg acacggcctc     3180

cctctgctac tccatcctga aagccaagaa cgcagggatg tcgctggggg ccaagggcgc     3240

cgccggccct ctgccctccg aggccgtgca gtggctgtgc caccaagcat tcctgctcaa     3300

gctgactcga caccgtgtca cctacgtgcc actcctgggg tcactcagga cagcccagac     3360

gcagctgagt cggaagctcc cggggacgac gctgactgcc ctggaggccg cagccaaccc     3420

ggcactgccc tcagacttca agaccatcct ggactgatgg ccacccgccc acagccaggc     3480

cgagagcaga caccagcagc cctgtcacgc cgggctctac gtcccaggga gggaggggcg     3540

gcccacaccc aggcccgcac cgctgggagt ctgaggcctg agtgagtgtt tggccgaggc     3600

ctgcatgtcc ggctgaaggc tgagtgtccg gctgaggcct gagcgagtgt ccagccaagg     3660

gctgagtgtc cagcacacct gccgtcttca cttccccaca ggctggcgct cggctccacc     3720

ccagggccag cttttcctca ccaggagccc ggcttccact ccccacatag gaatagtcca     3780

tccccagatt cgccattgtt cacccctcgc cctgccctcc tttgccttcc acccccacca     3840

tccaggtgga gaccctgaga aggaccctgg gagctctggg aatttggagt gaccaaaggt     3900

gtgccctgta cacaggcgag gaccctgcac ctggatgggg gtccctgtgg gtcaaattgg     3960

ggggaggtgc tgtgggagta aaatactgaa tatatgagtt tttcagtttt gaaaaaaa       4018


<210>  18
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Arg Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  19
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  20
<211>  2190
<212>  DNA
<213>  Homo sapiens

<400>  20
atgcagctgt ttgagcagcc ctgtcctggg gaggaccccc ggccaggagg ccagatcggt       60

gaggtggagc tgtcctccta cacgccccca gccggggtcc caggaaagcc tgcagccccc      120

cacttccttc cagtgctgtg ctctgtgtca ccatcaggct ccagggtccc gcacgacctc      180

ctcgggggct ccgggggctt cacgctggag gacgccctct tcgggctcct ctttggagct      240

gatgccaccc tcctgcagtc acctgtggtc ctctgtggtc tccctgatgg ccagctctgc      300

tgtgtgatcc tgaaggccct ggtcacctcc aggtcagccc ctggtgaccc aaatgccctt      360

gtcaagatcc tccatcacct ggaggagccc gtcatcttca taggggcctt gaagacagag      420

ccacaggctg cagaagctgc agagaatttt ctgcctgacg aggatgtgca ctgtgactgc      480

ctggtggcct ttggtcacca cggccggatg ctggccatca aggccagctg ggatgagtcc      540

gggaagctgg tgcccgagct gcgggagtac tgcctcccag gccctgtgct ctgcgctgcc      600

tgtggcgggg gtggccgcgt gtaccacagc accccttctg acctctgtgt ggtggatctg      660

tctcggggaa gcaccccgct gggccctgag cagcccgaag aaggcccggg aggcctgccc      720

cccatgctgt gcccagccag cctgaacatc tgcagtgtcg tctcgctgtc cgcgtctccc      780

aggacgcatg aaggtggcac caagctcctg gccctgtccg ccaaaggccg cctgatgacc      840

tgcagcctgg acctggactc tgagatgcct ggcccagcca ggatgaccac agagagtgca      900

ggtcagaaaa taaaggagct gctgtctgga attggcaaca tctctgagag agtgtctttt      960

ctaaagaagg cggttgacca gcggaacaag gcactgacaa gcctcaacga ggccatgaac     1020

gtgagctgtg cactgctgtc aagcggcacg ggccccagac ccatctcctg caccaccagc     1080

accacctgga gccgcctgca gacacaggat gtgctcatgg ccacctgcgt gctagagaac     1140

agcagcagct tcagcctgga ccaggggtgg accctgtgca tccaggtgct caccagctcc     1200

tgtgctctcg acctggactc ggcctgctcc gccatcacct acaccatccc cgtggaccag     1260

ctcggccccg gtgctcggcg ggaggtgacg ctacccctgg gccctggtga gaacggcggg     1320

ctcgacctgc ccgtgaccgt gtcctgcacg ctgttctaca gtctcaggga ggtggtgggc     1380

ggggcccttg cccccttaga ctctgaggac ccctttctgg atgagtgccc ctccgacgtc     1440

ctgcccgagc aagagggtgt ttgcctgccc ctgagcaggc acacagtgga catgctgcag     1500

tgtctgcgct tccctggcct ggccccgcca cacacacggg ccccctcccc actcggcccc     1560

acccgagacc ctgtggccac ttttctggaa acttgtcggg agcctggcag ccagccagca     1620

ggacccgcct ccctgcgggc cgagtacctg cccccatctg tggcttccat caaggtgtcg     1680

gcggagctgc tcagagctgc cttgaaggac ggccactcag gcgtgcccct gtgctgtgcc     1740

accctgcagt ggctccttgc tgagaatgct gctgtggacg tcgtgagggc ccgagcacta     1800

tcttccatcc agggagtggc ccctgatggc gccaacgttc acctcatcgt ccgagaggtg     1860

gccatgaccg acctgtgccc agcagggccc atccaggccg tggagattca agtggaaagc     1920

tcctctctgg ccgacatttg cagggcgcac catgccgttg tcgggcgcat gcagacgatg     1980

gtgacagagc aggccgccca gggctccagc gctcctgatc tccgtgtgca gtacctccgc     2040

cagatccacg ccaaccacga gacactgctg cgggaggtgc agaccctgcg cgaccggctc     2100

tgcacggagg atgaggccag ctcctgtgcc accgcccaga ggctgctaca ggtgtaccgg     2160

cagctgcgcc accccagcct catcctgctg                                      2190


<210>  21
<211>  2190
<212>  DNA
<213>  Homo sapiens

<400>  21
atgcagctgt ttgagcagcc ctgtcctggg gaggaccccc ggccaggagg ccagatcggt       60

gaggtggagc tgtcctccta cacgccccca gccggggtcc caggaaagcc tgcagccccc      120

cacttccttc cagtgctgtg ctctgtgtca ccatcaggct ccagggtccc gcacgacctc      180

ctcgggggct ccgggggctt cacgctggag gacgccctct tcgggctcct ctttggagct      240

gatgccaccc tcctgcagtc acctgtggtc ctctgtggtc tccctgatgg ccagctctgc      300

tgtgtgatcc tgaaggccct ggtcacctcc aggtcagccc ctggtgaccc aaatgccctt      360

gtcaagatcc tccatcacct ggaggagccc gtcatcttca taggggcctt gaagacagag      420

ccacaggctg cagaagctgc agagaatttt ctgcctgacg aggatgtgca ctgtgactgc      480

ctggtggcct ttggtcacca cggccggatg ctggccatca aggccagctg ggatgagtcc      540

gggaagctgg tgcccgagct gcgggagtac tgcctcccag gccctgtgct ctgcgctgcc      600

tgtggcgggg gtggccgcgt gtaccacagc accccttctg acctctgtgt ggtggatctg      660

tctcggggaa gcaccccgct gggccctgag cagcccgaag aaggcccggg aggcctgccc      720

cccatgctgt gcccagccag cctgaacatc tgcagtgtcg tctcgctgtc cgcgtctccc      780

aggacgcatg aaggtggcac caagctcctg gccctgtccg ccaaaggccg cctgatgacc      840

tgcagcctgg acctggactc tgagatgcct ggcccagcca ggatgaccac agagagtgca      900

ggtcagaaaa taaaggagct gctgtctgga attggcaaca tctctgagag agtgtctttt      960

ctaaagaagg cggttgacca gcggaacaag gcactgacaa gcctcaacga ggccatgaac     1020

gtgagctgtg cactgctgtc aagcggcacg ggccccagac ccatctcctg caccaccagc     1080

accacctgga gccgcctgca gacacaggat gtgctcatgg ccacctgcgt gctagagaac     1140

agcagcagct tcagcctgga ccaggggtgg accctgtgca tccaggtgct caccagctcc     1200

tgtgctctcg acctggactc ggcctgctcc gccatcacct acaccatccc cgtggaccag     1260

ctcggccccg gtgctcggcg ggaggtgacg ctacccctgg gccctggtga gaacggcggg     1320

ctcgacctgc ccgtgaccgt gtcctgcacg ctgttctaca gtctcaggga ggtggtgggc     1380

ggggcccttg ccccctcaga ctctgaggac ccctttctgg atgagtgccc ctccgacgtc     1440

ctgcccgagc aagagggtgt ttgcctgccc ctgagcaggc acacagtgga catgctgcag     1500

tgtctgcgct tccctggcct ggccccgcca cacacacggg ccccctcccc actcggcccc     1560

acccgagacc ctgtggccac ttttctggaa acttgtcggg agcctggcag ccagccagca     1620

ggacccgcct ccctgcgggc cgagtacctg cccccatctg tggcttccat caaggtgtcg     1680

gcggagctgc tcagagctgc cttgaaggac ggccactcag gcgtgcccct gtgctgtgcc     1740

accctgcagt ggctccttgc tgagaatgct gctgtggacg tcgtgagggc ccgagcacta     1800

tcttccatcc agggagtggc ccctgatggc gccaacgttc acctcatcgt ccgagaggtg     1860

gccatgaccg acctgtgccc agcagggccc atccaggccg tggagattca agtggaaagc     1920

tcctctctgg ccgacatttg cagggcgcac catgccgttg tcgggcgcat gcagacgatg     1980

gtgacagagc aggccgccca gggctccagc gctcctgatc tccgtgtgca gtacctccgc     2040

cagatccacg ccaaccacga gacactgctg cgggaggtgc agaccctgcg cgaccggctc     2100

tgcacggagg atgaggccag ctcctgtgcc accgcccaga ggctgctaca ggtgtaccgg     2160

cagctgcgcc accccagcct catcctgctg                                      2190


<210>  22
<211>  3163
<212>  DNA
<213>  Homo sapiens

<400>  22
ggacagtgtg ctggtcaccc tggtgcaggg ccctgcccga tggaagatgc agctgtttga       60

gcagccctgt cctggggagg acccccggcc aggaggccag atcggtgagg tggagctgtc      120

ctcctacacg cccccagccg gggtcccagg aaagcctgca gccccccact tccttccagt      180

gctgtgctct gtgtcaccat caggctccag ggtcccgcac gacctcctcg ggggctccgg      240

gggcttcacg ctggaggacg ccctcttcgg gctcctcttt ggagctgatg ccaccctcct      300

gcagtcacct gtggtcctct gtggtctccc tgatggccag ctctgctgtg tgatcctgaa      360

ggccctggtc acctccaggt cagcccctgg tgacccaaat gcccttgtca agatcctcca      420

tcacctggag gagcccgtca tcttcatagg ggccttgaag acagagccac aggctgcaga      480

agctgcagag aattttctgc ctgacgagga tgtgcactgt gactgcctgg tggcctttgg      540

tcaccacggc cggatgctgg ccatcaaggc cagctgggat gagtccggga agctggtgcc      600

cgagctgcgg gagtactgcc tcccaggccc tgtgctctgc gctgcctgtg gcgggggtgg      660

ccgcgtgtac cacagcaccc cttctgacct ctgtgtggtg gatctgtctc ggggaagcac      720

cccgctgggc cctgagcagc ccgaagaagg cccgggaggc ctgcccccca tgctgtgccc      780

agccagcctg aacatctgca gtgtcgtctc gctgtccgcg tctcccagga cgcatgaagg      840

tggcaccaag ctcctggccc tgtccgccaa aggccgcctg atgacctgca gcctggacct      900

ggactctgag atgcctggcc cagccaggat gaccacagag agtgcaggtc agaaaataaa      960

ggagctgctg tctggaattg gcaacatctc tgagagagtg tcttttctaa agaaggcggt     1020

tgaccagcgg aacaaggcac tgacaagcct caacgaggcc atgaacgtga gctgtgcact     1080

gctgtcaagc ggcacgggcc ccagacccat ctcctgcacc accagcacca cctggagccg     1140

cctgcagaca caggatgtgc tcatggccac ctgcgtgcta gagaacagca gcagcttcag     1200

cctggaccag gggtggaccc tgtgcatcca ggtgctcacc agctcctgtg ctctcgacct     1260

ggactcggcc tgctccgcca tcacctacac catccccgtg gaccagctcg gccccggtgc     1320

tcggcgggag gtgacgctac ccctgggccc tggtgagaac ggcgggctcg acctgcccgt     1380

gaccgtgtcc tgcacgctgt tctacagtct cagggaggtg gtgggcgggg cccttgcccc     1440

ctcagactct gaggacccct ttctggatga gtgcccctcc gacgtcctgc ccgagcaaga     1500

gggtgtttgc ctgcccctga gcaggcacac agtggacatg ctgcagtgtc tgcgcttccc     1560

tggcctggcc ccgccacaca cacgggcccc ctccccactc ggccccaccc gagaccctgt     1620

ggccactttt ctggaaactt gtcgggagcc tggcagccag ccagcaggac ccgcctccct     1680

gcgggccgag tacctgcccc catctgtggc ttccatcaag gtgtcggcgg agctgctcag     1740

agctgccttg aaggacggcc actcaggcgt gcccctgtgc tgtgccaccc tgcagtggct     1800

ccttgctgag aatgctgctg tggacgtcgt gagggcccga gcactatctt ccatccaggg     1860

agtggcccct gatggcgcca acgttcacct catcgtccga gaggtggcca tgaccgacct     1920

gtgcccagca gggcccatcc aggccgtgga gattcaagtg gaaagctcct ctctggccga     1980

catttgcagg gcgcaccatg ccgttgtcgg gcgcatgcag acgatggtga cagagcaggc     2040

cgcccagggc tccagcgctc ctgatctccg tgtgcagtac ctccgccaga tccacgccaa     2100

ccacgagaca ctgctgcggg aggtgcagac cctgcgcgac cggctctgca cggaggatga     2160

ggccagctcc tgtgccaccg cccagaggct gctacaggtg taccggcagc tgcgccaccc     2220

cagcctcatc ctgctgtgac caggcgggcc tgcccctggg ctctggccac gcttccagcc     2280

tctgtcacag cccccccagg cctcatgggt tagagggaaa ccgagctggc ctggccagag     2340

ccgtcaggga aggtaggacc tggccacgta ggagcagaac gctcatgaaa gtgcttggag     2400

gccgtggagc acaaagcaga ttctgattgg gagcaaccga ggcgggctct gaacctggcc     2460

ggtccagctt cgcgtcctct gctggtgtct ctccttctct gaccgcggcc gcagcccctg     2520

cactcgcctt cctcactgct gggcagcctt cccaccaccg cagcagcccc tgaggccagg     2580

aggcagtgca gggcattctg gacccggagg gccagagaaa caggatttct ggggtttgga     2640

cttggggtga gtttgtaact gttgctgcca caccaccagg agcaccggct gcccctctgg     2700

gtggcactac caggtgcccc acggtaccct tgtcacactg ttcacacctg cccggctgcc     2760

cactctggga ccccgaggta ggagggtgct ccctgagacc aaagcacaaa acagcatgca     2820

gggagctcct gcaagtgccc gtggtctcgt gccacaccaa ggaagggcca gcgggtggcc     2880

tgtggccgga atgctcaaca actaggtgcc tccggccggg gcagtaccca gcactgtgca     2940

ctattttcag ggccactcag ggtggcgctg tggcccgggg gggggccctg agccccagcc     3000

cccagcctcc tccctcagcc tgggctacgg cccacctcct ggtgctggtg ttttcatctg     3060

gggagggtgc tcgcgccgct cccgctgcag gcactgtccg cgatgagtgc gggtaggagc     3120

cgtgaggtgc ttctctgctg tgacaaacga ccctgtctgt ccg                       3163


<210>  23
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gln Leu Phe Glu Gln Pro Cys Pro Gly Glu Asp Pro Arg Pro Gly 
1               5                   10                  15      


Gly Gln Ile Gly Glu Val Glu Leu Ser Ser Tyr Thr Pro Pro Ala Gly 
            20                  25                  30          


Val Pro Gly Lys Pro Ala Ala Pro His Phe Leu Pro Val Leu Cys Ser 
        35                  40                  45              


Val Ser Pro Ser Gly Ser Arg Val Pro His Asp Leu Leu Gly Gly Ser 
    50                  55                  60                  


Gly Gly Phe Thr Leu Glu Asp Ala Leu Phe Gly Leu Leu Phe Gly Ala 
65                  70                  75                  80  


Asp Ala Thr Leu Leu Gln Ser Pro Val Val Leu Cys Gly Leu Pro Asp 
                85                  90                  95      


Gly Gln Leu Cys Cys Val Ile Leu Lys Ala Leu Val Thr Ser Arg Ser 
            100                 105                 110         


Ala Pro Gly Asp Pro Asn Ala Leu Val Lys Ile Leu His His Leu Glu 
        115                 120                 125             


Glu Pro Val Ile Phe Ile Gly Ala Leu Lys Thr Glu Pro Gln Ala Ala 
    130                 135                 140                 


Glu Ala Ala Glu Asn Phe Leu Pro Asp Glu Asp Val His Cys Asp Cys 
145                 150                 155                 160 


Leu Val Ala Phe Gly His His Gly Arg Met Leu Ala Ile Lys Ala Ser 
                165                 170                 175     


Trp Asp Glu Ser Gly Lys Leu Val Pro Glu Leu Arg Glu Tyr Cys Leu 
            180                 185                 190         


Pro Gly Pro Val Leu Cys Ala Ala Cys Gly Gly Gly Gly Arg Val Tyr 
        195                 200                 205             


His Ser Thr Pro Ser Asp Leu Cys Val Val Asp Leu Ser Arg Gly Ser 
    210                 215                 220                 


Thr Pro Leu Gly Pro Glu Gln Pro Glu Glu Gly Pro Gly Gly Leu Pro 
225                 230                 235                 240 


Pro Met Leu Cys Pro Ala Ser Leu Asn Ile Cys Ser Val Val Ser Leu 
                245                 250                 255     


Ser Ala Ser Pro Arg Thr His Glu Gly Gly Thr Lys Leu Leu Ala Leu 
            260                 265                 270         


Ser Ala Lys Gly Arg Leu Met Thr Cys Ser Leu Asp Leu Asp Ser Glu 
        275                 280                 285             


Met Pro Gly Pro Ala Arg Met Thr Thr Glu Ser Ala Gly Gln Lys Ile 
    290                 295                 300                 


Lys Glu Leu Leu Ser Gly Ile Gly Asn Ile Ser Glu Arg Val Ser Phe 
305                 310                 315                 320 


Leu Lys Lys Ala Val Asp Gln Arg Asn Lys Ala Leu Thr Ser Leu Asn 
                325                 330                 335     


Glu Ala Met Asn Val Ser Cys Ala Leu Leu Ser Ser Gly Thr Gly Pro 
            340                 345                 350         


Arg Pro Ile Ser Cys Thr Thr Ser Thr Thr Trp Ser Arg Leu Gln Thr 
        355                 360                 365             


Gln Asp Val Leu Met Ala Thr Cys Val Leu Glu Asn Ser Ser Ser Phe 
    370                 375                 380                 


Ser Leu Asp Gln Gly Trp Thr Leu Cys Ile Gln Val Leu Thr Ser Ser 
385                 390                 395                 400 


Cys Ala Leu Asp Leu Asp Ser Ala Cys Ser Ala Ile Thr Tyr Thr Ile 
                405                 410                 415     


Pro Val Asp Gln Leu Gly Pro Gly Ala Arg Arg Glu Val Thr Leu Pro 
            420                 425                 430         


Leu Gly Pro Gly Glu Asn Gly Gly Leu Asp Leu Pro Val Thr Val Ser 
        435                 440                 445             


Cys Thr Leu Phe Tyr Ser Leu Arg Glu Val Val Gly Gly Ala Leu Ala 
    450                 455                 460                 


Pro Leu Asp Ser Glu Asp Pro Phe Leu Asp Glu Cys Pro Ser Asp Val 
465                 470                 475                 480 


Leu Pro Glu Gln Glu Gly Val Cys Leu Pro Leu Ser Arg His Thr Val 
                485                 490                 495     


Asp Met Leu Gln Cys Leu Arg Phe Pro Gly Leu Ala Pro Pro His Thr 
            500                 505                 510         


Arg Ala Pro Ser Pro Leu Gly Pro Thr Arg Asp Pro Val Ala Thr Phe 
        515                 520                 525             


Leu Glu Thr Cys Arg Glu Pro Gly Ser Gln Pro Ala Gly Pro Ala Ser 
    530                 535                 540                 


Leu Arg Ala Glu Tyr Leu Pro Pro Ser Val Ala Ser Ile Lys Val Ser 
545                 550                 555                 560 


Ala Glu Leu Leu Arg Ala Ala Leu Lys Asp Gly His Ser Gly Val Pro 
                565                 570                 575     


Leu Cys Cys Ala Thr Leu Gln Trp Leu Leu Ala Glu Asn Ala Ala Val 
            580                 585                 590         


Asp Val Val Arg Ala Arg Ala Leu Ser Ser Ile Gln Gly Val Ala Pro 
        595                 600                 605             


Asp Gly Ala Asn Val His Leu Ile Val Arg Glu Val Ala Met Thr Asp 
    610                 615                 620                 


Leu Cys Pro Ala Gly Pro Ile Gln Ala Val Glu Ile Gln Val Glu Ser 
625                 630                 635                 640 


Ser Ser Leu Ala Asp Ile Cys Arg Ala His His Ala Val Val Gly Arg 
                645                 650                 655     


Met Gln Thr Met Val Thr Glu Gln Ala Ala Gln Gly Ser Ser Ala Pro 
            660                 665                 670         


Asp Leu Arg Val Gln Tyr Leu Arg Gln Ile His Ala Asn His Glu Thr 
        675                 680                 685             


Leu Leu Arg Glu Val Gln Thr Leu Arg Asp Arg Leu Cys Thr Glu Asp 
    690                 695                 700                 


Glu Ala Ser Ser Cys Ala Thr Ala Gln Arg Leu Leu Gln Val Tyr Arg 
705                 710                 715                 720 


Gln Leu Arg His Pro Ser Leu Ile Leu Leu 
                725                 730 


<210>  24
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gln Leu Phe Glu Gln Pro Cys Pro Gly Glu Asp Pro Arg Pro Gly 
1               5                   10                  15      


Gly Gln Ile Gly Glu Val Glu Leu Ser Ser Tyr Thr Pro Pro Ala Gly 
            20                  25                  30          


Val Pro Gly Lys Pro Ala Ala Pro His Phe Leu Pro Val Leu Cys Ser 
        35                  40                  45              


Val Ser Pro Ser Gly Ser Arg Val Pro His Asp Leu Leu Gly Gly Ser 
    50                  55                  60                  


Gly Gly Phe Thr Leu Glu Asp Ala Leu Phe Gly Leu Leu Phe Gly Ala 
65                  70                  75                  80  


Asp Ala Thr Leu Leu Gln Ser Pro Val Val Leu Cys Gly Leu Pro Asp 
                85                  90                  95      


Gly Gln Leu Cys Cys Val Ile Leu Lys Ala Leu Val Thr Ser Arg Ser 
            100                 105                 110         


Ala Pro Gly Asp Pro Asn Ala Leu Val Lys Ile Leu His His Leu Glu 
        115                 120                 125             


Glu Pro Val Ile Phe Ile Gly Ala Leu Lys Thr Glu Pro Gln Ala Ala 
    130                 135                 140                 


Glu Ala Ala Glu Asn Phe Leu Pro Asp Glu Asp Val His Cys Asp Cys 
145                 150                 155                 160 


Leu Val Ala Phe Gly His His Gly Arg Met Leu Ala Ile Lys Ala Ser 
                165                 170                 175     


Trp Asp Glu Ser Gly Lys Leu Val Pro Glu Leu Arg Glu Tyr Cys Leu 
            180                 185                 190         


Pro Gly Pro Val Leu Cys Ala Ala Cys Gly Gly Gly Gly Arg Val Tyr 
        195                 200                 205             


His Ser Thr Pro Ser Asp Leu Cys Val Val Asp Leu Ser Arg Gly Ser 
    210                 215                 220                 


Thr Pro Leu Gly Pro Glu Gln Pro Glu Glu Gly Pro Gly Gly Leu Pro 
225                 230                 235                 240 


Pro Met Leu Cys Pro Ala Ser Leu Asn Ile Cys Ser Val Val Ser Leu 
                245                 250                 255     


Ser Ala Ser Pro Arg Thr His Glu Gly Gly Thr Lys Leu Leu Ala Leu 
            260                 265                 270         


Ser Ala Lys Gly Arg Leu Met Thr Cys Ser Leu Asp Leu Asp Ser Glu 
        275                 280                 285             


Met Pro Gly Pro Ala Arg Met Thr Thr Glu Ser Ala Gly Gln Lys Ile 
    290                 295                 300                 


Lys Glu Leu Leu Ser Gly Ile Gly Asn Ile Ser Glu Arg Val Ser Phe 
305                 310                 315                 320 


Leu Lys Lys Ala Val Asp Gln Arg Asn Lys Ala Leu Thr Ser Leu Asn 
                325                 330                 335     


Glu Ala Met Asn Val Ser Cys Ala Leu Leu Ser Ser Gly Thr Gly Pro 
            340                 345                 350         


Arg Pro Ile Ser Cys Thr Thr Ser Thr Thr Trp Ser Arg Leu Gln Thr 
        355                 360                 365             


Gln Asp Val Leu Met Ala Thr Cys Val Leu Glu Asn Ser Ser Ser Phe 
    370                 375                 380                 


Ser Leu Asp Gln Gly Trp Thr Leu Cys Ile Gln Val Leu Thr Ser Ser 
385                 390                 395                 400 


Cys Ala Leu Asp Leu Asp Ser Ala Cys Ser Ala Ile Thr Tyr Thr Ile 
                405                 410                 415     


Pro Val Asp Gln Leu Gly Pro Gly Ala Arg Arg Glu Val Thr Leu Pro 
            420                 425                 430         


Leu Gly Pro Gly Glu Asn Gly Gly Leu Asp Leu Pro Val Thr Val Ser 
        435                 440                 445             


Cys Thr Leu Phe Tyr Ser Leu Arg Glu Val Val Gly Gly Ala Leu Ala 
    450                 455                 460                 


Pro Ser Asp Ser Glu Asp Pro Phe Leu Asp Glu Cys Pro Ser Asp Val 
465                 470                 475                 480 


Leu Pro Glu Gln Glu Gly Val Cys Leu Pro Leu Ser Arg His Thr Val 
                485                 490                 495     


Asp Met Leu Gln Cys Leu Arg Phe Pro Gly Leu Ala Pro Pro His Thr 
            500                 505                 510         


Arg Ala Pro Ser Pro Leu Gly Pro Thr Arg Asp Pro Val Ala Thr Phe 
        515                 520                 525             


Leu Glu Thr Cys Arg Glu Pro Gly Ser Gln Pro Ala Gly Pro Ala Ser 
    530                 535                 540                 


Leu Arg Ala Glu Tyr Leu Pro Pro Ser Val Ala Ser Ile Lys Val Ser 
545                 550                 555                 560 


Ala Glu Leu Leu Arg Ala Ala Leu Lys Asp Gly His Ser Gly Val Pro 
                565                 570                 575     


Leu Cys Cys Ala Thr Leu Gln Trp Leu Leu Ala Glu Asn Ala Ala Val 
            580                 585                 590         


Asp Val Val Arg Ala Arg Ala Leu Ser Ser Ile Gln Gly Val Ala Pro 
        595                 600                 605             


Asp Gly Ala Asn Val His Leu Ile Val Arg Glu Val Ala Met Thr Asp 
    610                 615                 620                 


Leu Cys Pro Ala Gly Pro Ile Gln Ala Val Glu Ile Gln Val Glu Ser 
625                 630                 635                 640 


Ser Ser Leu Ala Asp Ile Cys Arg Ala His His Ala Val Val Gly Arg 
                645                 650                 655     


Met Gln Thr Met Val Thr Glu Gln Ala Ala Gln Gly Ser Ser Ala Pro 
            660                 665                 670         


Asp Leu Arg Val Gln Tyr Leu Arg Gln Ile His Ala Asn His Glu Thr 
        675                 680                 685             


Leu Leu Arg Glu Val Gln Thr Leu Arg Asp Arg Leu Cys Thr Glu Asp 
    690                 695                 700                 


Glu Ala Ser Ser Cys Ala Thr Ala Gln Arg Leu Leu Gln Val Tyr Arg 
705                 710                 715                 720 


Gln Leu Arg His Pro Ser Leu Ile Leu Leu 
                725                 730 


<210>  25
<211>  6946
<212>  DNA
<213>  Homo sapiens

<400>  25
atgagcagcc gacggaaacg tgctcctcca gtgagggtag atgaggaaaa gaggcagcag       60

cttcattgga atatgcatga ggacagaagg aatgaaccta tcatcataag tgatgatgac      120

gagcagccct gcccaggttc agatacctct tctgctcatt atatcattct aagtgatagt      180

ctaaaggaag aagtggctca cagagataag aagaggtgtt caaaagtggt gagcttctca      240

aaaccaattg aaaaagaaga gactgttggt attttttccc ctttgtctgt aaagttaaat      300

attgtgattt ctccctatca ttttgataat tcctggaaag catttctagg agaattaact      360

cttcagcttc ttcctgcaca gagtttaatt gaaaattttt ccgaaaggag tattacattg      420

atgagttcag agtcaagcaa tcagttcctg atttatgttc attcaaaagg tgaagatgta      480

gagaaacaaa aaaaagaacc gatgagtatt tgtgacaagg gtattctggt ggagtcatcc      540

ttcagtggtg aaatgttaga agatttgggg tggctacaaa agaagagaag aataaaactc      600

tatcagaaac cagaaggaaa tcacattatc aaggttggaa tttatctttt ggaagctggc      660

ctagcaaaac tagacttctt gagtgatgca aattcaagaa tgaaaaagtt caatcagctc      720

atgaagaaag taatggaaaa gttacacaat tctattattc cagatgtgtt ggaagaggat      780

gaagatgatc cggagagtga gccagaggga caagacattg acgagctgta tcactttgtg      840

aaacaaacac atcagcaaga aacgcagtcc atccaagtgg atgtccagca tcctgcattg      900

atccctgtgt tgagacccta ccaaagagag gctgtcaatt ggatgctaca acaagagtgt      960

ttcagaagca gtcctgctac tgaaagtgcc ctgcacttct tatggcgaga gattgttaca     1020

tctgagggtc tgaaactcta ctataatcca tatacaggct gcatcattcg tgagtaccca     1080

aattctgggc cgcagttgct tggtggaatt ttagcagatg agatgggtct tggaaagaca     1140

gtggaggttt tggctctgat tctgacacat actcgacaag atgtcaagca agatgctctc     1200

actcttcccg agggaaaagt ggtgaattat tttattccgt cacattattt tggaggaaaa     1260

ctgaaaaaga cagaaatcca gaatatcgaa tttgaaccaa aagaaaaagt tcaatgccct     1320

cctacacgtg tgatgatact gacagctgtg aaagaaatga atggaaaaaa aggagtgtcc     1380

atcctttcca tctataagta tgtcagttct atatatagat acgatgttca acggaacagg     1440

agtcttttga aacggatgct gaaatgttta atttttgaag gtctcgtgaa acagatcaaa     1500

ggccatggtt tttctgggac ttttacattg ggaaagaatt acaaggaaga ggatatatgt     1560

gataaaacaa aaaagcaggc agtagggagt ccaaggaaaa ttcagaaaga aactagaaaa     1620

tcagggaaca aggacacaga ttctgaatac ttgccatcag acacctctga tgatgatgat     1680

gatccttact attattatta taagtccagg agaaatcgca gtaaattgag gaaaaagctt     1740

gttccatcca caaaaaaagg aaaaagtcaa ccatttatca atcccgattc acaaggtcac     1800

tgtccagcta ctagcgactc tggaataact gatgttgcta tgtctaaaag tacatgtatc     1860

tctgaattca accaagaaca tgaaacagag gactgtgctg aatctctaaa tcatgctgat     1920

agtgatgtac caccttctaa taccatgagt ccctttaaca cctctgatta ccgctttgag     1980

tgtatatgtg gtgaacttga tcagatagat cgtaagcctc gtgttcaatg cctgaagtgt     2040

cacctgtggc aacatgcaaa gtgtgtgaat tatgatgaga aaaatctgaa gatcaagcct     2100

ttttactgcc cccactgcct tgttgcaatg gaaccagtgt caacaagagc aactctgatc     2160

atctctccaa gttccatctg tcaccagtgg gtggatgaga tcaacaggca tgtgaggtcg     2220

tcatctcttc gagtcttggt atatcaagga gtgaagaaag atggcttttt acaacctcat     2280

tttttggcag aacaggatat agttatcatt acctatgatg tactgcgttc agaattaaat     2340

tatgtcgata tcccacatag caatagtgag gatgggcgtc gcctacggaa ccagaagcgc     2400

tatatggcta tcccgagccc cctggtagct gtggagtggt ggaggatctg ccttgatgaa     2460

gctcagatgg ttgagtgtcc cacagtaaaa gctgcagaaa tggcccagcg tttgagtggg     2520

attaatcgat ggtgtatcag tggcactcca gtacagagag gattagagga tctttttggg     2580

ttagtggtct ttcttggtat tgaaccttac tgtgtcaaac actggtgggt tcgacttctc     2640

tatcggcctt actgcaagaa gaatcctcag catctctaca gctttattgc caagatactg     2700

tggaggtctg caaagaaaga tgtgattgac caaatccaaa taccaccaca aaccgaagaa     2760

atacactggc tccacttttc tccagtggaa aggcatttct atcaccgtca gcatgaggtg     2820

tgctgccagg atgtggtggt aaaactcagg aagatttctg actgggctct gaagctcagc     2880

agcctagaca gaaggactgt cacctctatc ctgtatccat tgctgaggct cagacaggcc     2940

tgctgtcacc cacaggctgt tcgtggagag ttcttgccac tccaaaaaag caccatgaca     3000

atggaagagc tgctgacatc tttgcagaag aaatgtggaa ctgaatgtga agaagcacat     3060

cgacagctag tttgtgctct caatggctta gcaggcattc atattattaa aggtgagtat     3120

gccttggcag cagaattgta cagagaagtg ttgcgctcct cggaggaaca caaaggaaaa     3180

ctcaaaactg attcacttca aagacttcat gctacccata acttgatgga attgttgata     3240

gccaggcacc cagggatacc acctaccttg cgtgatggcc gacttgagga agaggccaaa     3300

cagctgcgag agcactacat gagcaagtgt aatacagaag ttgctgaagc ccagcaagct     3360

ttatatcctg tgcagcagac catccatgag cttcaaagaa agattcattc taattctcct     3420

tggtggctaa atgtgatcca cagagcaata gaatttacta ttgatgagga gctagttcag     3480

cgagtgcgaa atgaaataac cagcaactac aagcaacaaa ctggcaagct ttctatgtca     3540

gagaagttct gtgattgcag aggtcttcag ttcttactta caacacaaat ggaagagcta     3600

aataaatgcc agaagctagt aagagaggct gtaaaaaacc tggagggacc tccatctcgt     3660

aatgttattg agtctgcaac agtctgtcac ctccgaccag ccagacttcc tctcaactgc     3720

tgtgtctttt gtaaagctga tgaattgttc acagagtatg aatcaaagct attttccaac     3780

acagtcaaag gccagactgc aatatttgag gagatgatag aagatgaaga aggactggtg     3840

gatgatcgag cacctaccac cacccggggt ctctgggcaa taagtgagac agagcgatct     3900

atgaaagcaa tactatcatt tgcaaaatca cataggtttg atgttgaatt tgttgatgaa     3960

ggaagcactt caatggatct ctttgaagca tggaagaagg aatataagtt gcttcatgaa     4020

tattggatgg ctctgaggaa tcgtgtgtct gctgttgatg aacttgcaat ggctacagaa     4080

cgactaagag tgcgtgatcc tagggagcca aagcctaatc cgcctgttct tcatatcatt     4140

gaaccacatg aggtagaaca aaaccgaata aaactactaa atgataaagc tgttgctaca     4200

tcacagcttc agaaaaaact tgggcagctt ctttacctaa ctaatttgga gaagtctcaa     4260

gataaaacat cgggaggtgt taatccagaa ccttgcccaa tctgtgctcg acagctagga     4320

aaacagtggg cggtactgac ctgtggtcac tgtttctgta atgaatgcat ttctataatt     4380

attgaacaat acagcgtggg atctcacaga agctccatta agtgtgcaat ctgccgccag     4440

accacatctc acaaagaaat ctcgtatgtc tttacctcag agaaagcaaa ccaggaggag     4500

gacatccctg tgaagggcag ccattctaca aaagtggaag ctgtggtcag aactctgatg     4560

aaaatacagc ttagagatcc aggggccaaa gcactcgttt tctcaacgtg gcaagatgta     4620

ttagatatta tttcaaaagc tcttactgac aacaacatgg aatttgcaca aatcagtcgt     4680

gttaagacat ttcaggagaa cctttcagca tttaaacgtg atccccaaat caatattttg     4740

ctgctgcccc tgcacacagg ttctaatgga ttaactatca ttgaagcaac tcatgttctc     4800

ttggtggagc ccatattgaa ccctgcccat gagcttcagg ccatagggag ggtgcaccga     4860

attggacaga caaaacctac tattgtacac agattcttaa ttaaagcaac aatagaagaa     4920

agaatgcagg caatgctgaa aactgctgag agaagtcaca cgaactcatc agcaaagcat     4980

tcagaggcct ctgtcttgac tgtggctgac ctggcagacc tatttaccaa agaaactgaa     5040

gagcttgaat gaactacact tgattcattc catggacttt agtgtattaa taaactttca     5100

tagctgtaga gcaaagttac aagttttaaa aacccagtag ataacagtaa cactgttcct     5160

agttgaatga atttgtttat tgttctggtt atacagtggc ttagtactta ttgagtcctt     5220

ttcaatatac tgtttccaaa agatctataa agattcttaa ttttacactc ctaataaaac     5280

atttattttt tgtcccaaat agtatctata tctgatgatg caagggaatt aagagaggta     5340

atgtgtactt ttcttatgat aagatcactc ataaaacagt tggaataaga aagtaaacta     5400

gtctagtttt atatgacctg gtatattgaa caaacataga tctcagtttt ggaagggcct     5460

tcagtatctt tagcacatga ttcaccaata tcttgttagt aatattttaa gtagatggtg     5520

aattatatta acccattttt tgagtaggct tataccataa ctttacacct agtaattttg     5580

cagtaataca actccttaca ataagttaat gttagacagt tatttgtttc ttctgcatct     5640

tgctactgaa aacaaaaaca atgaaaatat tcatatttct attatgtgta aagtggtgtt     5700

agtgtaaaca gttaactcca aatagatttt ttaatgtatt aatgattacc ttaaaattat     5760

ctgctttccc tactcttaat ttttcttatt gttaaagttt ttatatgttg taagattgat     5820

gtatctgtaa atattgcagt ttttatgatt ttgttttatt ataacatgga aatatggcag     5880

ggtttttttt ttaatcatta ttatactgat gtcttggatt ctttttcttt cccatgttct     5940

tgtgtaacta gactttttag ccagtgatat ctgaattcat ggtagagttg ttatttcact     6000

ccagttgttc ctcccttaag cacgagtctt tgaccttttg aacaagagaa tgccatgttc     6060

acataagcaa atcgttgcaa gtgataataa cgaagtgttt cttcttctgt gaggaattaa     6120

tggactttga aattgctgaa taaggagtag cttgttacat cctagccatt tgatgtaata     6180

caaatgttct tatttggctt ccttttcttt gagccttcag agttttaaag gaccctcttt     6240

gaccctcagg acttattagc tcccagttag ctgcctggaa aactcataga accattccct     6300

agatcccatt tgtccgagag gctttggtgc ttagttaagg tgcattttct tactctaggt     6360

ttatagagtg atgtaattca actgaagaaa acacacacat gcttttggtg cttattcttc     6420

agttaaaagg aggtatccat tgattctttt atatgaaatt aaatcaaact gttattttta     6480

tagctcttca catattaaaa agagctttca tgtacattta cgtgtttaat ttacccaaca     6540

atcttgtgaa gttgatataa ttaatatctt tactgtttta aaggtagaga actgaagttc     6600

agatatattg aaactttctt aggacatgta gcaagtaaac agtggagccc aggtcccctg     6660

actccatatc ttacattctt ttactaataa catgtcatgc tgagattcag aaggcccatg     6720

cttataattt aaaaatgaga ctatttcagt atttctttgt gtttgttttc tactattcct     6780

ttctgagcta tgttttagag aaaacaattt gatatgcttc aattttgtaa aatcaaatta     6840

catatatata aaaaaaccta tctgtattag acaaaaactg tttttattta tttctgtaag     6900

atatccatta aataaatatt ttagtggaaa tgaaaaaaaa aaaaaa                    6946


<210>  26
<211>  6946
<212>  DNA
<213>  Homo sapiens

<400>  26
atgagcagcc gacggaaacg tgctcctcca gtgagggtag atgaggaaaa gaggcagcag       60

cttcattgga atatgcatga ggacagaagg aatgaaccta tcatcataag tgatgatgac      120

gagcagccct gcccaggttc agatacctct tctgctcatt atatcattct aagtgatagt      180

ctaaaggaag aagtggctca cagagataag aagaggtgtt caaaagtggt gagcttctca      240

aaaccaattg aaaaagaaga gactgttggt attttttccc ctttgtctgt aaagttaaat      300

attgtgattt ctccctatca ttttgataat tcctggaaag catttctagg agaattaact      360

cttcagcttc ttcctgcaca gagtttaatt gaaaattttt ccgaaaggag tattacattg      420

atgagttcag agtcaagcaa tcagttcctg atttatgttc attcaaaagg tgaagatgta      480

gagaaacaaa aaaaagaacc gatgagtatt tgtgacaagg gtattctggt ggagtcatcc      540

ttcagtggtg aaatgttaga agatttgggg tggctacaaa agaagagaag aataaaactc      600

tatcagaaac cagaaggaaa tcacattatc aaggttggaa tttatctttt ggaagctggc      660

ctagcaaaac tagacttctt gagtgatgca aattcaagaa tgaaaaagtt caatcagctc      720

atgaagaaag taatggaaaa gttacacaat tctattattc cagatgtgtt ggaagaggat      780

gaagatgatc cggagagtga gccagaggga caagacattg acgagctgta tcactttgtg      840

aaacaaacac atcagcaaga aacgcagtcc atccaagtgg atgtccagca tcctgcattg      900

atccctgtgt tgagacccta ccaaagagag gctgtcaatt ggatgctaca acaagagtgt      960

ttcagaagca gtcctgctac tgaaagtgcc ctgcacttct tatggcgaga gattgttaca     1020

tctgagggtc tgaaactcta ctataatcca tatacaggct gcatcattcg tgagtaccca     1080

aattctgggc cgcagttgct tggtggaatt ttagcagatg agatgggtct tggaaagaca     1140

gtggaggttt tggctctgat tctgacacat actcgacaag atgtcaagca agatgctctc     1200

actcttcccg agggaaaagt ggtgaattat tttattccgt cacattattt tggaggaaaa     1260

ctgaaaaaga cagaaatcca gaatatcgaa tttgaaccaa aagaaaaagt tcaatgccct     1320

cctacacgtg tgatgatact gacagctgtg aaagaaatga atggaaaaaa aggagtgtcc     1380

atcctttcca tctataagta tgtcagttct atatatagat acgatgttca acggaacagg     1440

agtcttttga aacggatgct gaaatgttta atttttgaag gtctcgtgaa acagatcaaa     1500

ggccatggtt tttctgggac ttttacattg ggaaagaatt acaaggaaga ggatatatgt     1560

gataaaacaa aaaagcaggc agtagggagt ccaaggaaaa ttcagaaaga aactagaaaa     1620

tcagggaaca aggacacaga ttctgaatac ttgccatcag acacctctga tgatgatgat     1680

gatccttact attattatta taagtccagg agaaatcgca gtaaattgag gaaaaagctt     1740

gttccatcca caaaaaaagg aaaaagtcaa ccatttatca atcccgattc acaaggtcac     1800

tgtccagcta ctagcgactc tggaataact gatgttgcta tgtctaaaag tacatgtatc     1860

tctgaattca accaagaaca tgaaacagag gactgtgctg aatctctaaa tcatgctgat     1920

agtgatgtac caccttctaa taccatgagt ccctttaaca cctctgatta ccgctttgag     1980

tgtatatgtg gtgaacttga tcagatagat cgtaagcctc gtgttcaatg cctgaagtgt     2040

cacctgtggc aacatgcaaa gtgtgtgaat tatgatgaga aaaatctgaa gatcaagcct     2100

ttttactgcc cccactgcct tgttgcaatg gaaccagtgt caacaagagc aactctgatc     2160

atctctccaa gttccatctg tcaccagtgg gtggatgaga tcaacaggca tgtgaggtcg     2220

tcatctcttc gagtcttggt atatcaagga gtgaagaaag atggcttttt acaacctcat     2280

tttttggcag aacaggatat agttatcatt acctatgatg tactgcgttc agaattaaat     2340

tatgtcgata tcccacatag caatagtgag gatgggcgtc gcctacggaa ccagaagcgc     2400

tatatggcta tcccgagccc cctggtagct gtggagtggt ggaggatctg ccttgatgaa     2460

gctcagatgg ttgagtgtcc cacagtaaaa gctgcagaaa tggcccagcg tttgagtggg     2520

attaatcgat ggtgtatcag tggcactcca gtacagagag gattagagga tctttttggg     2580

ttagtggtct ttcttggtat tgaaccttac tgtgtcaaac actggtgggt tcgacttctc     2640

tatcggcctt actgcaagaa gaatcctcag catctctaca gctttattgc caagatactg     2700

tggaggtctg caaagaaaga tgtgattgac caaatccaaa taccaccaca aaccgaagaa     2760

atacactggc tccacttttc tccagtggaa aggcatttct atcaccgtca gcatgaggtg     2820

tgctgccagg atgtggtggt aaaactcagg aagatttctg actgggctct gaagctcagc     2880

agcctagaca gaaggactgt cacctctatc ctgtatccat tgctgaggct cagacaggcc     2940

tgctgtcacc cacaggctgt tcgtggagag ttcttgccac tccaaaaaag caccatgaca     3000

atggaagagc tgctgacatc tttgcagaag aaatgtggaa ctgaatgtga agaagcacat     3060

cgacagctag tttgtgctct caatggctta gcaggcattc atattattaa aggtgagtat     3120

gccttggcag cagaattgta cagagaagtg ttgcgctcct cggaggaaca caaaggaaaa     3180

ctcaaaactg attcacttca aagacttcat gctacccata acttgatgga attgttgata     3240

gccaggcacc cagggatacc acctaccttg cgtgatggcc gacttgagga agaggccaaa     3300

cagctgcgag agcactacat gagcaagtgt aatacagaag ttgctgaagc ccagcaagct     3360

ttatatcctg tgcagcagac catccatgag cttcaaagaa agattcattc taattctcct     3420

tggtggctaa atgtgatcca cagagcaata gaatttacta ttgatgagga gctagttcag     3480

cgagtgcgaa atgaaataac cagcaactac aagcaacaaa ctggcaagct ttctatgtca     3540

gagaagttcc gtgattgcag aggtcttcag ttcttactta caacacaaat ggaagagcta     3600

aataaatgcc agaagctagt aagagaggct gtaaaaaacc tggagggacc tccatctcgt     3660

aatgttattg agtctgcaac agtctgtcac ctccgaccag ccagacttcc tctcaactgc     3720

tgtgtctttt gtaaagctga tgaattgttc acagagtatg aatcaaagct attttccaac     3780

acagtcaaag gccagactgc aatatttgag gagatgatag aagatgaaga aggactggtg     3840

gatgatcgag cacctaccac cacccggggt ctctgggcaa taagtgagac agagcgatct     3900

atgaaagcaa tactatcatt tgcaaaatca cataggtttg atgttgaatt tgttgatgaa     3960

ggaagcactt caatggatct ctttgaagca tggaagaagg aatataagtt gcttcatgaa     4020

tattggatgg ctctgaggaa tcgtgtgtct gctgttgatg aacttgcaat ggctacagaa     4080

cgactaagag tgcgtgatcc tagggagcca aagcctaatc cgcctgttct tcatatcatt     4140

gaaccacatg aggtagaaca aaaccgaata aaactactaa atgataaagc tgttgctaca     4200

tcacagcttc agaaaaaact tgggcagctt ctttacctaa ctaatttgga gaagtctcaa     4260

gataaaacat cgggaggtgt taatccagaa ccttgcccaa tctgtgctcg acagctagga     4320

aaacagtggg cggtactgac ctgtggtcac tgtttctgta atgaatgcat ttctataatt     4380

attgaacaat acagcgtggg atctcacaga agctccatta agtgtgcaat ctgccgccag     4440

accacatctc acaaagaaat ctcgtatgtc tttacctcag agaaagcaaa ccaggaggag     4500

gacatccctg tgaagggcag ccattctaca aaagtggaag ctgtggtcag aactctgatg     4560

aaaatacagc ttagagatcc aggggccaaa gcactcgttt tctcaacgtg gcaagatgta     4620

ttagatatta tttcaaaagc tcttactgac aacaacatgg aatttgcaca aatcagtcgt     4680

gttaagacat ttcaggagaa cctttcagca tttaaacgtg atccccaaat caatattttg     4740

ctgctgcccc tgcacacagg ttctaatgga ttaactatca ttgaagcaac tcatgttctc     4800

ttggtggagc ccatattgaa ccctgcccat gagcttcagg ccatagggag ggtgcaccga     4860

attggacaga caaaacctac tattgtacac agattcttaa ttaaagcaac aatagaagaa     4920

agaatgcagg caatgctgaa aactgctgag agaagtcaca cgaactcatc agcaaagcat     4980

tcagaggcct ctgtcttgac tgtggctgac ctggcagacc tatttaccaa agaaactgaa     5040

gagcttgaat gaactacact tgattcattc catggacttt agtgtattaa taaactttca     5100

tagctgtaga gcaaagttac aagttttaaa aacccagtag ataacagtaa cactgttcct     5160

agttgaatga atttgtttat tgttctggtt atacagtggc ttagtactta ttgagtcctt     5220

ttcaatatac tgtttccaaa agatctataa agattcttaa ttttacactc ctaataaaac     5280

atttattttt tgtcccaaat agtatctata tctgatgatg caagggaatt aagagaggta     5340

atgtgtactt ttcttatgat aagatcactc ataaaacagt tggaataaga aagtaaacta     5400

gtctagtttt atatgacctg gtatattgaa caaacataga tctcagtttt ggaagggcct     5460

tcagtatctt tagcacatga ttcaccaata tcttgttagt aatattttaa gtagatggtg     5520

aattatatta acccattttt tgagtaggct tataccataa ctttacacct agtaattttg     5580

cagtaataca actccttaca ataagttaat gttagacagt tatttgtttc ttctgcatct     5640

tgctactgaa aacaaaaaca atgaaaatat tcatatttct attatgtgta aagtggtgtt     5700

agtgtaaaca gttaactcca aatagatttt ttaatgtatt aatgattacc ttaaaattat     5760

ctgctttccc tactcttaat ttttcttatt gttaaagttt ttatatgttg taagattgat     5820

gtatctgtaa atattgcagt ttttatgatt ttgttttatt ataacatgga aatatggcag     5880

ggtttttttt ttaatcatta ttatactgat gtcttggatt ctttttcttt cccatgttct     5940

tgtgtaacta gactttttag ccagtgatat ctgaattcat ggtagagttg ttatttcact     6000

ccagttgttc ctcccttaag cacgagtctt tgaccttttg aacaagagaa tgccatgttc     6060

acataagcaa atcgttgcaa gtgataataa cgaagtgttt cttcttctgt gaggaattaa     6120

tggactttga aattgctgaa taaggagtag cttgttacat cctagccatt tgatgtaata     6180

caaatgttct tatttggctt ccttttcttt gagccttcag agttttaaag gaccctcttt     6240

gaccctcagg acttattagc tcccagttag ctgcctggaa aactcataga accattccct     6300

agatcccatt tgtccgagag gctttggtgc ttagttaagg tgcattttct tactctaggt     6360

ttatagagtg atgtaattca actgaagaaa acacacacat gcttttggtg cttattcttc     6420

agttaaaagg aggtatccat tgattctttt atatgaaatt aaatcaaact gttattttta     6480

tagctcttca catattaaaa agagctttca tgtacattta cgtgtttaat ttacccaaca     6540

atcttgtgaa gttgatataa ttaatatctt tactgtttta aaggtagaga actgaagttc     6600

agatatattg aaactttctt aggacatgta gcaagtaaac agtggagccc aggtcccctg     6660

actccatatc ttacattctt ttactaataa catgtcatgc tgagattcag aaggcccatg     6720

cttataattt aaaaatgaga ctatttcagt atttctttgt gtttgttttc tactattcct     6780

ttctgagcta tgttttagag aaaacaattt gatatgcttc aattttgtaa aatcaaatta     6840

catatatata aaaaaaccta tctgtattag acaaaaactg tttttattta tttctgtaag     6900

atatccatta aataaatatt ttagtggaaa tgaaaaaaaa aaaaaa                    6946


<210>  27
<211>  7345
<212>  DNA
<213>  Homo sapiens

<400>  27
gtctttggcc tccgggacca gggagggagg acgctggttg tcctggagcc cgggaagctc       60

aagggctgag agggagccgc tgcgcgagtc ttccccacct cttcccgatc ccggactagc      120

gaacttcgga ccaccacgtc cctccgggga taaagtgggg tcgtgggaaa ggaggctgtg      180

cttctcctca tgcactgggg cctgcggtgt ttgtctcgag cgtccaacac actaggatcc      240

gggagtccgt cgtcacgctc cttggcctcg cggtcgcttg tttgctcggc ctgctgggag      300

cgatccggcg ctgacagccc cgctcagact ccgggagccg cttgtgggtc tttcggaaga      360

taactgaagt tcacagttac cagccaagaa aacttgaaaa tgagcagccg acggaaacgt      420

gctcctccag tgagggtaga tgaggaaaag aggcagcagc ttcattggaa tatgcatgag      480

gacagaagga atgaacctat catcataagt gatgatgacg agcagccctg cccaggttca      540

gatacctctt ctgctcatta tatcattcta agtgatagtc taaaggaaga agtggctcac      600

agagataaga agaggtgttc aaaagtggtg agcttctcaa aaccaattga aaaagaagag      660

actgttggta ttttttcccc tttgtctgta aagttaaata ttgtgatttc tccctatcat      720

tttgataatt cctggaaagc atttctagga gaattaactc ttcagcttct tcctgcacag      780

agtttaattg aaaatttttc cgaaaggagt attacattga tgagttcaga gtcaagcaat      840

cagttcctga tttatgttca ttcaaaaggt gaagatgtag agaaacaaaa aaaagaaccg      900

atgagtattt gtgacaaggg tattctggtg gagtcatcct tcagtggtga aatgttagaa      960

gatttggggt ggctacaaaa gaagagaaga ataaaactct atcagaaacc agaaggaaat     1020

cacattatca aggttggaat ttatcttttg gaagctggcc tagcaaaact agacttcttg     1080

agtgatgcaa attcaagaat gaaaaagttc aatcagctca tgaagaaagt aatggaaaag     1140

ttacacaatt ctattattcc agatgtgttg gaagaggatg aagatgatcc ggagagtgag     1200

ccagagggac aagacattga cgagctgtat cactttgtga aacaaacaca tcagcaagaa     1260

acgcagtcca tccaagtgga tgtccagcat cctgcattga tccctgtgtt gagaccctac     1320

caaagagagg ctgtcaattg gatgctacaa caagagtgtt tcagaagcag tcctgctact     1380

gaaagtgccc tgcacttctt atggcgagag attgttacat ctgagggtct gaaactctac     1440

tataatccat atacaggctg catcattcgt gagtacccaa attctgggcc gcagttgctt     1500

ggtggaattt tagcagatga gatgggtctt ggaaagacag tggaggtttt ggctctgatt     1560

ctgacacata ctcgacaaga tgtcaagcaa gatgctctca ctcttcccga gggaaaagtg     1620

gtgaattatt ttattccgtc acattatttt ggaggaaaac tgaaaaagac agaaatccag     1680

aatatcgaat ttgaaccaaa agaaaaagtt caatgccctc ctacacgtgt gatgatactg     1740

acagctgtga aagaaatgaa tggaaaaaaa ggagtgtcca tcctttccat ctataagtat     1800

gtcagttcta tatatagata cgatgttcaa cggaacagga gtcttttgaa acggatgctg     1860

aaatgtttaa tttttgaagg tctcgtgaaa cagatcaaag gccatggttt ttctgggact     1920

tttacattgg gaaagaatta caaggaagag gatatatgtg ataaaacaaa aaagcaggca     1980

gtagggagtc caaggaaaat tcagaaagaa actagaaaat cagggaacaa ggacacagat     2040

tctgaatact tgccatcaga cacctctgat gatgatgatg atccttacta ttattattat     2100

aagtccagga gaaatcgcag taaattgagg aaaaagcttg ttccatccac aaaaaaagga     2160

aaaagtcaac catttatcaa tcccgattca caaggtcact gtccagctac tagcgactct     2220

ggaataactg atgttgctat gtctaaaagt acatgtatct ctgaattcaa ccaagaacat     2280

gaaacagagg actgtgctga atctctaaat catgctgata gtgatgtacc accttctaat     2340

accatgagtc cctttaacac ctctgattac cgctttgagt gtatatgtgg tgaacttgat     2400

cagatagatc gtaagcctcg tgttcaatgc ctgaagtgtc acctgtggca acatgcaaag     2460

tgtgtgaatt atgatgagaa aaatctgaag atcaagcctt tttactgccc ccactgcctt     2520

gttgcaatgg aaccagtgtc aacaagagca actctgatca tctctccaag ttccatctgt     2580

caccagtggg tggatgagat caacaggcat gtgaggtcgt catctcttcg agtcttggta     2640

tatcaaggag tgaagaaaga tggcttttta caacctcatt ttttggcaga acaggatata     2700

gttatcatta cctatgatgt actgcgttca gaattaaatt atgtcgatat cccacatagc     2760

aatagtgagg atgggcgtcg cctacggaac cagaagcgct atatggctat cccgagcccc     2820

ctggtagctg tggagtggtg gaggatctgc cttgatgaag ctcagatggt tgagtgtccc     2880

acagtaaaag ctgcagaaat ggcccagcgt ttgagtggga ttaatcgatg gtgtatcagt     2940

ggcactccag tacagagagg attagaggat ctttttgggt tagtggtctt tcttggtatt     3000

gaaccttact gtgtcaaaca ctggtgggtt cgacttctct atcggcctta ctgcaagaag     3060

aatcctcagc atctctacag ctttattgcc aagatactgt ggaggtctgc aaagaaagat     3120

gtgattgacc aaatccaaat accaccacaa accgaagaaa tacactggct ccacttttct     3180

ccagtggaaa ggcatttcta tcaccgtcag catgaggtgt gctgccagga tgtggtggta     3240

aaactcagga agatttctga ctgggctctg aagctcagca gcctagacag aaggactgtc     3300

acctctatcc tgtatccatt gctgaggctc agacaggcct gctgtcaccc acaggctgtt     3360

cgtggagagt tcttgccact ccaaaaaagc accatgacaa tggaagagct gctgacatct     3420

ttgcagaaga aatgtggaac tgaatgtgaa gaagcacatc gacagctagt ttgtgctctc     3480

aatggcttag caggcattca tattattaaa ggtgagtatg ccttggcagc agaattgtac     3540

agagaagtgt tgcgctcctc ggaggaacac aaaggaaaac tcaaaactga ttcacttcaa     3600

agacttcatg ctacccataa cttgatggaa ttgttgatag ccaggcaccc agggatacca     3660

cctaccttgc gtgatggccg acttgaggaa gaggccaaac agctgcgaga gcactacatg     3720

agcaagtgta atacagaagt tgctgaagcc cagcaagctt tatatcctgt gcagcagacc     3780

atccatgagc ttcaaagaaa gattcattct aattctcctt ggtggctaaa tgtgatccac     3840

agagcaatag aatttactat tgatgaggag ctagttcagc gagtgcgaaa tgaaataacc     3900

agcaactaca agcaacaaac tggcaagctt tctatgtcag agaagttccg tgattgcaga     3960

ggtcttcagt tcttacttac aacacaaatg gaagagctaa ataaatgcca gaagctagta     4020

agagaggctg taaaaaacct ggagggacct ccatctcgta atgttattga gtctgcaaca     4080

gtctgtcacc tccgaccagc cagacttcct ctcaactgct gtgtcttttg taaagctgat     4140

gaattgttca cagagtatga atcaaagcta ttttccaaca cagtcaaagg ccagactgca     4200

atatttgagg agatgataga agatgaagaa ggactggtgg atgatcgagc acctaccacc     4260

acccggggtc tctgggcaat aagtgagaca gagcgatcta tgaaagcaat actatcattt     4320

gcaaaatcac ataggtttga tgttgaattt gttgatgaag gaagcacttc aatggatctc     4380

tttgaagcat ggaagaagga atataagttg cttcatgaat attggatggc tctgaggaat     4440

cgtgtgtctg ctgttgatga acttgcaatg gctacagaac gactaagagt gcgtgatcct     4500

agggagccaa agcctaatcc gcctgttctt catatcattg aaccacatga ggtagaacaa     4560

aaccgaataa aactactaaa tgataaagct gttgctacat cacagcttca gaaaaaactt     4620

gggcagcttc tttacctaac taatttggag aagtctcaag ataaaacatc gggaggtgtt     4680

aatccagaac cttgcccaat ctgtgctcga cagctaggaa aacagtgggc ggtactgacc     4740

tgtggtcact gtttctgtaa tgaatgcatt tctataatta ttgaacaata cagcgtggga     4800

tctcacagaa gctccattaa gtgtgcaatc tgccgccaga ccacatctca caaagaaatc     4860

tcgtatgtct ttacctcaga gaaagcaaac caggaggagg acatccctgt gaagggcagc     4920

cattctacaa aagtggaagc tgtggtcaga actctgatga aaatacagct tagagatcca     4980

ggggccaaag cactcgtttt ctcaacgtgg caagatgtat tagatattat ttcaaaagct     5040

cttactgaca acaacatgga atttgcacaa atcagtcgtg ttaagacatt tcaggagaac     5100

ctttcagcat ttaaacgtga tccccaaatc aatattttgc tgctgcccct gcacacaggt     5160

tctaatggat taactatcat tgaagcaact catgttctct tggtggagcc catattgaac     5220

cctgcccatg agcttcaggc catagggagg gtgcaccgaa ttggacagac aaaacctact     5280

attgtacaca gattcttaat taaagcaaca atagaagaaa gaatgcaggc aatgctgaaa     5340

actgctgaga gaagtcacac gaactcatca gcaaagcatt cagaggcctc tgtcttgact     5400

gtggctgacc tggcagacct atttaccaaa gaaactgaag agcttgaatg aactacactt     5460

gattcattcc atggacttta gtgtattaat aaactttcat agctgtagag caaagttaca     5520

agttttaaaa acccagtaga taacagtaac actgttccta gttgaatgaa tttgtttatt     5580

gttctggtta tacagtggct tagtacttat tgagtccttt tcaatatact gtttccaaaa     5640

gatctataaa gattcttaat tttacactcc taataaaaca tttatttttt gtcccaaata     5700

gtatctatat ctgatgatgc aagggaatta agagaggtaa tgtgtacttt tcttatgata     5760

agatcactca taaaacagtt ggaataagaa agtaaactag tctagtttta tatgacctgg     5820

tatattgaac aaacatagat ctcagttttg gaagggcctt cagtatcttt agcacatgat     5880

tcaccaatat cttgttagta atattttaag tagatggtga attatattaa cccatttttt     5940

gagtaggctt ataccataac tttacaccta gtaattttgc agtaatacaa ctccttacaa     6000

taagttaatg ttagacagtt atttgtttct tctgcatctt gctactgaaa acaaaaacaa     6060

tgaaaatatt catatttcta ttatgtgtaa agtggtgtta gtgtaaacag ttaactccaa     6120

atagattttt taatgtatta atgattacct taaaattatc tgctttccct actcttaatt     6180

tttcttattg ttaaagtttt tatatgttgt aagattgatg tatctgtaaa tattgcagtt     6240

tttatgattt tgttttatta taacatggaa atatggcagg gttttttttt taatcattat     6300

tatactgatg tcttggattc tttttctttc ccatgttctt gtgtaactag actttttagc     6360

cagtgatatc tgaattcatg gtagagttgt tatttcactc cagttgttcc tcccttaagc     6420

acgagtcttt gaccttttga acaagagaat gccatgttca cataagcaaa tcgttgcaag     6480

tgataataac gaagtgtttc ttcttctgtg aggaattaat ggactttgaa attgctgaat     6540

aaggagtagc ttgttacatc ctagccattt gatgtaatac aaatgttctt atttggcttc     6600

cttttctttg agccttcaga gttttaaagg accctctttg accctcagga cttattagct     6660

cccagttagc tgcctggaaa actcatagaa ccattcccta gatcccattt gtccgagagg     6720

ctttggtgct tagttaaggt gcattttctt actctaggtt tatagagtga tgtaattcaa     6780

ctgaagaaaa cacacacatg cttttggtgc ttattcttca gttaaaagga ggtatccatt     6840

gattctttta tatgaaatta aatcaaactg ttatttttat agctcttcac atattaaaaa     6900

gagctttcat gtacatttac gtgtttaatt tacccaacaa tcttgtgaag ttgatataat     6960

taatatcttt actgttttaa aggtagagaa ctgaagttca gatatattga aactttctta     7020

ggacatgtag caagtaaaca gtggagccca ggtcccctga ctccatatct tacattcttt     7080

tactaataac atgtcatgct gagattcaga aggcccatgc ttataattta aaaatgagac     7140

tatttcagta tttctttgtg tttgttttct actattcctt tctgagctat gttttagaga     7200

aaacaatttg atatgcttca attttgtaaa atcaaattac atatatataa aaaaacctat     7260

ctgtattaga caaaaactgt ttttatttat ttctgtaaga tatccattaa ataaatattt     7320

tagtggaaat gaaaaaaaaa aaaaa                                           7345


<210>  28
<211>  1683
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Ser Arg Arg Lys Arg Ala Pro Pro Val Arg Val Asp Glu Glu 
1               5                   10                  15      


Lys Arg Gln Gln Leu His Trp Asn Met His Glu Asp Arg Arg Asn Glu 
            20                  25                  30          


Pro Ile Ile Ile Ser Asp Asp Asp Glu Gln Pro Cys Pro Gly Ser Asp 
        35                  40                  45              


Thr Ser Ser Ala His Tyr Ile Ile Leu Ser Asp Ser Leu Lys Glu Glu 
    50                  55                  60                  


Val Ala His Arg Asp Lys Lys Arg Cys Ser Lys Val Val Ser Phe Ser 
65                  70                  75                  80  


Lys Pro Ile Glu Lys Glu Glu Thr Val Gly Ile Phe Ser Pro Leu Ser 
                85                  90                  95      


Val Lys Leu Asn Ile Val Ile Ser Pro Tyr His Phe Asp Asn Ser Trp 
            100                 105                 110         


Lys Ala Phe Leu Gly Glu Leu Thr Leu Gln Leu Leu Pro Ala Gln Ser 
        115                 120                 125             


Leu Ile Glu Asn Phe Ser Glu Arg Ser Ile Thr Leu Met Ser Ser Glu 
    130                 135                 140                 


Ser Ser Asn Gln Phe Leu Ile Tyr Val His Ser Lys Gly Glu Asp Val 
145                 150                 155                 160 


Glu Lys Gln Lys Lys Glu Pro Met Ser Ile Cys Asp Lys Gly Ile Leu 
                165                 170                 175     


Val Glu Ser Ser Phe Ser Gly Glu Met Leu Glu Asp Leu Gly Trp Leu 
            180                 185                 190         


Gln Lys Lys Arg Arg Ile Lys Leu Tyr Gln Lys Pro Glu Gly Asn His 
        195                 200                 205             


Ile Ile Lys Val Gly Ile Tyr Leu Leu Glu Ala Gly Leu Ala Lys Leu 
    210                 215                 220                 


Asp Phe Leu Ser Asp Ala Asn Ser Arg Met Lys Lys Phe Asn Gln Leu 
225                 230                 235                 240 


Met Lys Lys Val Met Glu Lys Leu His Asn Ser Ile Ile Pro Asp Val 
                245                 250                 255     


Leu Glu Glu Asp Glu Asp Asp Pro Glu Ser Glu Pro Glu Gly Gln Asp 
            260                 265                 270         


Ile Asp Glu Leu Tyr His Phe Val Lys Gln Thr His Gln Gln Glu Thr 
        275                 280                 285             


Gln Ser Ile Gln Val Asp Val Gln His Pro Ala Leu Ile Pro Val Leu 
    290                 295                 300                 


Arg Pro Tyr Gln Arg Glu Ala Val Asn Trp Met Leu Gln Gln Glu Cys 
305                 310                 315                 320 


Phe Arg Ser Ser Pro Ala Thr Glu Ser Ala Leu His Phe Leu Trp Arg 
                325                 330                 335     


Glu Ile Val Thr Ser Glu Gly Leu Lys Leu Tyr Tyr Asn Pro Tyr Thr 
            340                 345                 350         


Gly Cys Ile Ile Arg Glu Tyr Pro Asn Ser Gly Pro Gln Leu Leu Gly 
        355                 360                 365             


Gly Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Val Glu Val Leu 
    370                 375                 380                 


Ala Leu Ile Leu Thr His Thr Arg Gln Asp Val Lys Gln Asp Ala Leu 
385                 390                 395                 400 


Thr Leu Pro Glu Gly Lys Val Val Asn Tyr Phe Ile Pro Ser His Tyr 
                405                 410                 415     


Phe Gly Gly Lys Leu Lys Lys Thr Glu Ile Gln Asn Ile Glu Phe Glu 
            420                 425                 430         


Pro Lys Glu Lys Val Gln Cys Pro Pro Thr Arg Val Met Ile Leu Thr 
        435                 440                 445             


Ala Val Lys Glu Met Asn Gly Lys Lys Gly Val Ser Ile Leu Ser Ile 
    450                 455                 460                 


Tyr Lys Tyr Val Ser Ser Ile Tyr Arg Tyr Asp Val Gln Arg Asn Arg 
465                 470                 475                 480 


Ser Leu Leu Lys Arg Met Leu Lys Cys Leu Ile Phe Glu Gly Leu Val 
                485                 490                 495     


Lys Gln Ile Lys Gly His Gly Phe Ser Gly Thr Phe Thr Leu Gly Lys 
            500                 505                 510         


Asn Tyr Lys Glu Glu Asp Ile Cys Asp Lys Thr Lys Lys Gln Ala Val 
        515                 520                 525             


Gly Ser Pro Arg Lys Ile Gln Lys Glu Thr Arg Lys Ser Gly Asn Lys 
    530                 535                 540                 


Asp Thr Asp Ser Glu Tyr Leu Pro Ser Asp Thr Ser Asp Asp Asp Asp 
545                 550                 555                 560 


Asp Pro Tyr Tyr Tyr Tyr Tyr Lys Ser Arg Arg Asn Arg Ser Lys Leu 
                565                 570                 575     


Arg Lys Lys Leu Val Pro Ser Thr Lys Lys Gly Lys Ser Gln Pro Phe 
            580                 585                 590         


Ile Asn Pro Asp Ser Gln Gly His Cys Pro Ala Thr Ser Asp Ser Gly 
        595                 600                 605             


Ile Thr Asp Val Ala Met Ser Lys Ser Thr Cys Ile Ser Glu Phe Asn 
    610                 615                 620                 


Gln Glu His Glu Thr Glu Asp Cys Ala Glu Ser Leu Asn His Ala Asp 
625                 630                 635                 640 


Ser Asp Val Pro Pro Ser Asn Thr Met Ser Pro Phe Asn Thr Ser Asp 
                645                 650                 655     


Tyr Arg Phe Glu Cys Ile Cys Gly Glu Leu Asp Gln Ile Asp Arg Lys 
            660                 665                 670         


Pro Arg Val Gln Cys Leu Lys Cys His Leu Trp Gln His Ala Lys Cys 
        675                 680                 685             


Val Asn Tyr Asp Glu Lys Asn Leu Lys Ile Lys Pro Phe Tyr Cys Pro 
    690                 695                 700                 


His Cys Leu Val Ala Met Glu Pro Val Ser Thr Arg Ala Thr Leu Ile 
705                 710                 715                 720 


Ile Ser Pro Ser Ser Ile Cys His Gln Trp Val Asp Glu Ile Asn Arg 
                725                 730                 735     


His Val Arg Ser Ser Ser Leu Arg Val Leu Val Tyr Gln Gly Val Lys 
            740                 745                 750         


Lys Asp Gly Phe Leu Gln Pro His Phe Leu Ala Glu Gln Asp Ile Val 
        755                 760                 765             


Ile Ile Thr Tyr Asp Val Leu Arg Ser Glu Leu Asn Tyr Val Asp Ile 
    770                 775                 780                 


Pro His Ser Asn Ser Glu Asp Gly Arg Arg Leu Arg Asn Gln Lys Arg 
785                 790                 795                 800 


Tyr Met Ala Ile Pro Ser Pro Leu Val Ala Val Glu Trp Trp Arg Ile 
                805                 810                 815     


Cys Leu Asp Glu Ala Gln Met Val Glu Cys Pro Thr Val Lys Ala Ala 
            820                 825                 830         


Glu Met Ala Gln Arg Leu Ser Gly Ile Asn Arg Trp Cys Ile Ser Gly 
        835                 840                 845             


Thr Pro Val Gln Arg Gly Leu Glu Asp Leu Phe Gly Leu Val Val Phe 
    850                 855                 860                 


Leu Gly Ile Glu Pro Tyr Cys Val Lys His Trp Trp Val Arg Leu Leu 
865                 870                 875                 880 


Tyr Arg Pro Tyr Cys Lys Lys Asn Pro Gln His Leu Tyr Ser Phe Ile 
                885                 890                 895     


Ala Lys Ile Leu Trp Arg Ser Ala Lys Lys Asp Val Ile Asp Gln Ile 
            900                 905                 910         


Gln Ile Pro Pro Gln Thr Glu Glu Ile His Trp Leu His Phe Ser Pro 
        915                 920                 925             


Val Glu Arg His Phe Tyr His Arg Gln His Glu Val Cys Cys Gln Asp 
    930                 935                 940                 


Val Val Val Lys Leu Arg Lys Ile Ser Asp Trp Ala Leu Lys Leu Ser 
945                 950                 955                 960 


Ser Leu Asp Arg Arg Thr Val Thr Ser Ile Leu Tyr Pro Leu Leu Arg 
                965                 970                 975     


Leu Arg Gln Ala Cys Cys His Pro Gln Ala Val Arg Gly Glu Phe Leu 
            980                 985                 990         


Pro Leu Gln Lys Ser Thr Met Thr  Met Glu Glu Leu Leu  Thr Ser Leu 
        995                 1000                 1005             


Gln Lys  Lys Cys Gly Thr Glu  Cys Glu Glu Ala His  Arg Gln Leu 
    1010                 1015                 1020             


Val Cys  Ala Leu Asn Gly Leu  Ala Gly Ile His Ile  Ile Lys Gly 
    1025                 1030                 1035             


Glu Tyr  Ala Leu Ala Ala Glu  Leu Tyr Arg Glu Val  Leu Arg Ser 
    1040                 1045                 1050             


Ser Glu  Glu His Lys Gly Lys  Leu Lys Thr Asp Ser  Leu Gln Arg 
    1055                 1060                 1065             


Leu His  Ala Thr His Asn Leu  Met Glu Leu Leu Ile  Ala Arg His 
    1070                 1075                 1080             


Pro Gly  Ile Pro Pro Thr Leu  Arg Asp Gly Arg Leu  Glu Glu Glu 
    1085                 1090                 1095             


Ala Lys  Gln Leu Arg Glu His  Tyr Met Ser Lys Cys  Asn Thr Glu 
    1100                 1105                 1110             


Val Ala  Glu Ala Gln Gln Ala  Leu Tyr Pro Val Gln  Gln Thr Ile 
    1115                 1120                 1125             


His Glu  Leu Gln Arg Lys Ile  His Ser Asn Ser Pro  Trp Trp Leu 
    1130                 1135                 1140             


Asn Val  Ile His Arg Ala Ile  Glu Phe Thr Ile Asp  Glu Glu Leu 
    1145                 1150                 1155             


Val Gln  Arg Val Arg Asn Glu  Ile Thr Ser Asn Tyr  Lys Gln Gln 
    1160                 1165                 1170             


Thr Gly  Lys Leu Ser Met Ser  Glu Lys Phe Cys Asp  Cys Arg Gly 
    1175                 1180                 1185             


Leu Gln  Phe Leu Leu Thr Thr  Gln Met Glu Glu Leu  Asn Lys Cys 
    1190                 1195                 1200             


Gln Lys  Leu Val Arg Glu Ala  Val Lys Asn Leu Glu  Gly Pro Pro 
    1205                 1210                 1215             


Ser Arg  Asn Val Ile Glu Ser  Ala Thr Val Cys His  Leu Arg Pro 
    1220                 1225                 1230             


Ala Arg  Leu Pro Leu Asn Cys  Cys Val Phe Cys Lys  Ala Asp Glu 
    1235                 1240                 1245             


Leu Phe  Thr Glu Tyr Glu Ser  Lys Leu Phe Ser Asn  Thr Val Lys 
    1250                 1255                 1260             


Gly Gln  Thr Ala Ile Phe Glu  Glu Met Ile Glu Asp  Glu Glu Gly 
    1265                 1270                 1275             


Leu Val  Asp Asp Arg Ala Pro  Thr Thr Thr Arg Gly  Leu Trp Ala 
    1280                 1285                 1290             


Ile Ser  Glu Thr Glu Arg Ser  Met Lys Ala Ile Leu  Ser Phe Ala 
    1295                 1300                 1305             


Lys Ser  His Arg Phe Asp Val  Glu Phe Val Asp Glu  Gly Ser Thr 
    1310                 1315                 1320             


Ser Met  Asp Leu Phe Glu Ala  Trp Lys Lys Glu Tyr  Lys Leu Leu 
    1325                 1330                 1335             


His Glu  Tyr Trp Met Ala Leu  Arg Asn Arg Val Ser  Ala Val Asp 
    1340                 1345                 1350             


Glu Leu  Ala Met Ala Thr Glu  Arg Leu Arg Val Arg  Asp Pro Arg 
    1355                 1360                 1365             


Glu Pro  Lys Pro Asn Pro Pro  Val Leu His Ile Ile  Glu Pro His 
    1370                 1375                 1380             


Glu Val  Glu Gln Asn Arg Ile  Lys Leu Leu Asn Asp  Lys Ala Val 
    1385                 1390                 1395             


Ala Thr  Ser Gln Leu Gln Lys  Lys Leu Gly Gln Leu  Leu Tyr Leu 
    1400                 1405                 1410             


Thr Asn  Leu Glu Lys Ser Gln  Asp Lys Thr Ser Gly  Gly Val Asn 
    1415                 1420                 1425             


Pro Glu  Pro Cys Pro Ile Cys  Ala Arg Gln Leu Gly  Lys Gln Trp 
    1430                 1435                 1440             


Ala Val  Leu Thr Cys Gly His  Cys Phe Cys Asn Glu  Cys Ile Ser 
    1445                 1450                 1455             


Ile Ile  Ile Glu Gln Tyr Ser  Val Gly Ser His Arg  Ser Ser Ile 
    1460                 1465                 1470             


Lys Cys  Ala Ile Cys Arg Gln  Thr Thr Ser His Lys  Glu Ile Ser 
    1475                 1480                 1485             


Tyr Val  Phe Thr Ser Glu Lys  Ala Asn Gln Glu Glu  Asp Ile Pro 
    1490                 1495                 1500             


Val Lys  Gly Ser His Ser Thr  Lys Val Glu Ala Val  Val Arg Thr 
    1505                 1510                 1515             


Leu Met  Lys Ile Gln Leu Arg  Asp Pro Gly Ala Lys  Ala Leu Val 
    1520                 1525                 1530             


Phe Ser  Thr Trp Gln Asp Val  Leu Asp Ile Ile Ser  Lys Ala Leu 
    1535                 1540                 1545             


Thr Asp  Asn Asn Met Glu Phe  Ala Gln Ile Ser Arg  Val Lys Thr 
    1550                 1555                 1560             


Phe Gln  Glu Asn Leu Ser Ala  Phe Lys Arg Asp Pro  Gln Ile Asn 
    1565                 1570                 1575             


Ile Leu  Leu Leu Pro Leu His  Thr Gly Ser Asn Gly  Leu Thr Ile 
    1580                 1585                 1590             


Ile Glu  Ala Thr His Val Leu  Leu Val Glu Pro Ile  Leu Asn Pro 
    1595                 1600                 1605             


Ala His  Glu Leu Gln Ala Ile  Gly Arg Val His Arg  Ile Gly Gln 
    1610                 1615                 1620             


Thr Lys  Pro Thr Ile Val His  Arg Phe Leu Ile Lys  Ala Thr Ile 
    1625                 1630                 1635             


Glu Glu  Arg Met Gln Ala Met  Leu Lys Thr Ala Glu  Arg Ser His 
    1640                 1645                 1650             


Thr Asn  Ser Ser Ala Lys His  Ser Glu Ala Ser Val  Leu Thr Val 
    1655                 1660                 1665             


Ala Asp  Leu Ala Asp Leu Phe  Thr Lys Glu Thr Glu  Glu Leu Glu 
    1670                 1675                 1680             


<210>  29
<211>  1683
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Ser Arg Arg Lys Arg Ala Pro Pro Val Arg Val Asp Glu Glu 
1               5                   10                  15      


Lys Arg Gln Gln Leu His Trp Asn Met His Glu Asp Arg Arg Asn Glu 
            20                  25                  30          


Pro Ile Ile Ile Ser Asp Asp Asp Glu Gln Pro Cys Pro Gly Ser Asp 
        35                  40                  45              


Thr Ser Ser Ala His Tyr Ile Ile Leu Ser Asp Ser Leu Lys Glu Glu 
    50                  55                  60                  


Val Ala His Arg Asp Lys Lys Arg Cys Ser Lys Val Val Ser Phe Ser 
65                  70                  75                  80  


Lys Pro Ile Glu Lys Glu Glu Thr Val Gly Ile Phe Ser Pro Leu Ser 
                85                  90                  95      


Val Lys Leu Asn Ile Val Ile Ser Pro Tyr His Phe Asp Asn Ser Trp 
            100                 105                 110         


Lys Ala Phe Leu Gly Glu Leu Thr Leu Gln Leu Leu Pro Ala Gln Ser 
        115                 120                 125             


Leu Ile Glu Asn Phe Ser Glu Arg Ser Ile Thr Leu Met Ser Ser Glu 
    130                 135                 140                 


Ser Ser Asn Gln Phe Leu Ile Tyr Val His Ser Lys Gly Glu Asp Val 
145                 150                 155                 160 


Glu Lys Gln Lys Lys Glu Pro Met Ser Ile Cys Asp Lys Gly Ile Leu 
                165                 170                 175     


Val Glu Ser Ser Phe Ser Gly Glu Met Leu Glu Asp Leu Gly Trp Leu 
            180                 185                 190         


Gln Lys Lys Arg Arg Ile Lys Leu Tyr Gln Lys Pro Glu Gly Asn His 
        195                 200                 205             


Ile Ile Lys Val Gly Ile Tyr Leu Leu Glu Ala Gly Leu Ala Lys Leu 
    210                 215                 220                 


Asp Phe Leu Ser Asp Ala Asn Ser Arg Met Lys Lys Phe Asn Gln Leu 
225                 230                 235                 240 


Met Lys Lys Val Met Glu Lys Leu His Asn Ser Ile Ile Pro Asp Val 
                245                 250                 255     


Leu Glu Glu Asp Glu Asp Asp Pro Glu Ser Glu Pro Glu Gly Gln Asp 
            260                 265                 270         


Ile Asp Glu Leu Tyr His Phe Val Lys Gln Thr His Gln Gln Glu Thr 
        275                 280                 285             


Gln Ser Ile Gln Val Asp Val Gln His Pro Ala Leu Ile Pro Val Leu 
    290                 295                 300                 


Arg Pro Tyr Gln Arg Glu Ala Val Asn Trp Met Leu Gln Gln Glu Cys 
305                 310                 315                 320 


Phe Arg Ser Ser Pro Ala Thr Glu Ser Ala Leu His Phe Leu Trp Arg 
                325                 330                 335     


Glu Ile Val Thr Ser Glu Gly Leu Lys Leu Tyr Tyr Asn Pro Tyr Thr 
            340                 345                 350         


Gly Cys Ile Ile Arg Glu Tyr Pro Asn Ser Gly Pro Gln Leu Leu Gly 
        355                 360                 365             


Gly Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Val Glu Val Leu 
    370                 375                 380                 


Ala Leu Ile Leu Thr His Thr Arg Gln Asp Val Lys Gln Asp Ala Leu 
385                 390                 395                 400 


Thr Leu Pro Glu Gly Lys Val Val Asn Tyr Phe Ile Pro Ser His Tyr 
                405                 410                 415     


Phe Gly Gly Lys Leu Lys Lys Thr Glu Ile Gln Asn Ile Glu Phe Glu 
            420                 425                 430         


Pro Lys Glu Lys Val Gln Cys Pro Pro Thr Arg Val Met Ile Leu Thr 
        435                 440                 445             


Ala Val Lys Glu Met Asn Gly Lys Lys Gly Val Ser Ile Leu Ser Ile 
    450                 455                 460                 


Tyr Lys Tyr Val Ser Ser Ile Tyr Arg Tyr Asp Val Gln Arg Asn Arg 
465                 470                 475                 480 


Ser Leu Leu Lys Arg Met Leu Lys Cys Leu Ile Phe Glu Gly Leu Val 
                485                 490                 495     


Lys Gln Ile Lys Gly His Gly Phe Ser Gly Thr Phe Thr Leu Gly Lys 
            500                 505                 510         


Asn Tyr Lys Glu Glu Asp Ile Cys Asp Lys Thr Lys Lys Gln Ala Val 
        515                 520                 525             


Gly Ser Pro Arg Lys Ile Gln Lys Glu Thr Arg Lys Ser Gly Asn Lys 
    530                 535                 540                 


Asp Thr Asp Ser Glu Tyr Leu Pro Ser Asp Thr Ser Asp Asp Asp Asp 
545                 550                 555                 560 


Asp Pro Tyr Tyr Tyr Tyr Tyr Lys Ser Arg Arg Asn Arg Ser Lys Leu 
                565                 570                 575     


Arg Lys Lys Leu Val Pro Ser Thr Lys Lys Gly Lys Ser Gln Pro Phe 
            580                 585                 590         


Ile Asn Pro Asp Ser Gln Gly His Cys Pro Ala Thr Ser Asp Ser Gly 
        595                 600                 605             


Ile Thr Asp Val Ala Met Ser Lys Ser Thr Cys Ile Ser Glu Phe Asn 
    610                 615                 620                 


Gln Glu His Glu Thr Glu Asp Cys Ala Glu Ser Leu Asn His Ala Asp 
625                 630                 635                 640 


Ser Asp Val Pro Pro Ser Asn Thr Met Ser Pro Phe Asn Thr Ser Asp 
                645                 650                 655     


Tyr Arg Phe Glu Cys Ile Cys Gly Glu Leu Asp Gln Ile Asp Arg Lys 
            660                 665                 670         


Pro Arg Val Gln Cys Leu Lys Cys His Leu Trp Gln His Ala Lys Cys 
        675                 680                 685             


Val Asn Tyr Asp Glu Lys Asn Leu Lys Ile Lys Pro Phe Tyr Cys Pro 
    690                 695                 700                 


His Cys Leu Val Ala Met Glu Pro Val Ser Thr Arg Ala Thr Leu Ile 
705                 710                 715                 720 


Ile Ser Pro Ser Ser Ile Cys His Gln Trp Val Asp Glu Ile Asn Arg 
                725                 730                 735     


His Val Arg Ser Ser Ser Leu Arg Val Leu Val Tyr Gln Gly Val Lys 
            740                 745                 750         


Lys Asp Gly Phe Leu Gln Pro His Phe Leu Ala Glu Gln Asp Ile Val 
        755                 760                 765             


Ile Ile Thr Tyr Asp Val Leu Arg Ser Glu Leu Asn Tyr Val Asp Ile 
    770                 775                 780                 


Pro His Ser Asn Ser Glu Asp Gly Arg Arg Leu Arg Asn Gln Lys Arg 
785                 790                 795                 800 


Tyr Met Ala Ile Pro Ser Pro Leu Val Ala Val Glu Trp Trp Arg Ile 
                805                 810                 815     


Cys Leu Asp Glu Ala Gln Met Val Glu Cys Pro Thr Val Lys Ala Ala 
            820                 825                 830         


Glu Met Ala Gln Arg Leu Ser Gly Ile Asn Arg Trp Cys Ile Ser Gly 
        835                 840                 845             


Thr Pro Val Gln Arg Gly Leu Glu Asp Leu Phe Gly Leu Val Val Phe 
    850                 855                 860                 


Leu Gly Ile Glu Pro Tyr Cys Val Lys His Trp Trp Val Arg Leu Leu 
865                 870                 875                 880 


Tyr Arg Pro Tyr Cys Lys Lys Asn Pro Gln His Leu Tyr Ser Phe Ile 
                885                 890                 895     


Ala Lys Ile Leu Trp Arg Ser Ala Lys Lys Asp Val Ile Asp Gln Ile 
            900                 905                 910         


Gln Ile Pro Pro Gln Thr Glu Glu Ile His Trp Leu His Phe Ser Pro 
        915                 920                 925             


Val Glu Arg His Phe Tyr His Arg Gln His Glu Val Cys Cys Gln Asp 
    930                 935                 940                 


Val Val Val Lys Leu Arg Lys Ile Ser Asp Trp Ala Leu Lys Leu Ser 
945                 950                 955                 960 


Ser Leu Asp Arg Arg Thr Val Thr Ser Ile Leu Tyr Pro Leu Leu Arg 
                965                 970                 975     


Leu Arg Gln Ala Cys Cys His Pro Gln Ala Val Arg Gly Glu Phe Leu 
            980                 985                 990         


Pro Leu Gln Lys Ser Thr Met Thr  Met Glu Glu Leu Leu  Thr Ser Leu 
        995                 1000                 1005             


Gln Lys  Lys Cys Gly Thr Glu  Cys Glu Glu Ala His  Arg Gln Leu 
    1010                 1015                 1020             


Val Cys  Ala Leu Asn Gly Leu  Ala Gly Ile His Ile  Ile Lys Gly 
    1025                 1030                 1035             


Glu Tyr  Ala Leu Ala Ala Glu  Leu Tyr Arg Glu Val  Leu Arg Ser 
    1040                 1045                 1050             


Ser Glu  Glu His Lys Gly Lys  Leu Lys Thr Asp Ser  Leu Gln Arg 
    1055                 1060                 1065             


Leu His  Ala Thr His Asn Leu  Met Glu Leu Leu Ile  Ala Arg His 
    1070                 1075                 1080             


Pro Gly  Ile Pro Pro Thr Leu  Arg Asp Gly Arg Leu  Glu Glu Glu 
    1085                 1090                 1095             


Ala Lys  Gln Leu Arg Glu His  Tyr Met Ser Lys Cys  Asn Thr Glu 
    1100                 1105                 1110             


Val Ala  Glu Ala Gln Gln Ala  Leu Tyr Pro Val Gln  Gln Thr Ile 
    1115                 1120                 1125             


His Glu  Leu Gln Arg Lys Ile  His Ser Asn Ser Pro  Trp Trp Leu 
    1130                 1135                 1140             


Asn Val  Ile His Arg Ala Ile  Glu Phe Thr Ile Asp  Glu Glu Leu 
    1145                 1150                 1155             


Val Gln  Arg Val Arg Asn Glu  Ile Thr Ser Asn Tyr  Lys Gln Gln 
    1160                 1165                 1170             


Thr Gly  Lys Leu Ser Met Ser  Glu Lys Phe Arg Asp  Cys Arg Gly 
    1175                 1180                 1185             


Leu Gln  Phe Leu Leu Thr Thr  Gln Met Glu Glu Leu  Asn Lys Cys 
    1190                 1195                 1200             


Gln Lys  Leu Val Arg Glu Ala  Val Lys Asn Leu Glu  Gly Pro Pro 
    1205                 1210                 1215             


Ser Arg  Asn Val Ile Glu Ser  Ala Thr Val Cys His  Leu Arg Pro 
    1220                 1225                 1230             


Ala Arg  Leu Pro Leu Asn Cys  Cys Val Phe Cys Lys  Ala Asp Glu 
    1235                 1240                 1245             


Leu Phe  Thr Glu Tyr Glu Ser  Lys Leu Phe Ser Asn  Thr Val Lys 
    1250                 1255                 1260             


Gly Gln  Thr Ala Ile Phe Glu  Glu Met Ile Glu Asp  Glu Glu Gly 
    1265                 1270                 1275             


Leu Val  Asp Asp Arg Ala Pro  Thr Thr Thr Arg Gly  Leu Trp Ala 
    1280                 1285                 1290             


Ile Ser  Glu Thr Glu Arg Ser  Met Lys Ala Ile Leu  Ser Phe Ala 
    1295                 1300                 1305             


Lys Ser  His Arg Phe Asp Val  Glu Phe Val Asp Glu  Gly Ser Thr 
    1310                 1315                 1320             


Ser Met  Asp Leu Phe Glu Ala  Trp Lys Lys Glu Tyr  Lys Leu Leu 
    1325                 1330                 1335             


His Glu  Tyr Trp Met Ala Leu  Arg Asn Arg Val Ser  Ala Val Asp 
    1340                 1345                 1350             


Glu Leu  Ala Met Ala Thr Glu  Arg Leu Arg Val Arg  Asp Pro Arg 
    1355                 1360                 1365             


Glu Pro  Lys Pro Asn Pro Pro  Val Leu His Ile Ile  Glu Pro His 
    1370                 1375                 1380             


Glu Val  Glu Gln Asn Arg Ile  Lys Leu Leu Asn Asp  Lys Ala Val 
    1385                 1390                 1395             


Ala Thr  Ser Gln Leu Gln Lys  Lys Leu Gly Gln Leu  Leu Tyr Leu 
    1400                 1405                 1410             


Thr Asn  Leu Glu Lys Ser Gln  Asp Lys Thr Ser Gly  Gly Val Asn 
    1415                 1420                 1425             


Pro Glu  Pro Cys Pro Ile Cys  Ala Arg Gln Leu Gly  Lys Gln Trp 
    1430                 1435                 1440             


Ala Val  Leu Thr Cys Gly His  Cys Phe Cys Asn Glu  Cys Ile Ser 
    1445                 1450                 1455             


Ile Ile  Ile Glu Gln Tyr Ser  Val Gly Ser His Arg  Ser Ser Ile 
    1460                 1465                 1470             


Lys Cys  Ala Ile Cys Arg Gln  Thr Thr Ser His Lys  Glu Ile Ser 
    1475                 1480                 1485             


Tyr Val  Phe Thr Ser Glu Lys  Ala Asn Gln Glu Glu  Asp Ile Pro 
    1490                 1495                 1500             


Val Lys  Gly Ser His Ser Thr  Lys Val Glu Ala Val  Val Arg Thr 
    1505                 1510                 1515             


Leu Met  Lys Ile Gln Leu Arg  Asp Pro Gly Ala Lys  Ala Leu Val 
    1520                 1525                 1530             


Phe Ser  Thr Trp Gln Asp Val  Leu Asp Ile Ile Ser  Lys Ala Leu 
    1535                 1540                 1545             


Thr Asp  Asn Asn Met Glu Phe  Ala Gln Ile Ser Arg  Val Lys Thr 
    1550                 1555                 1560             


Phe Gln  Glu Asn Leu Ser Ala  Phe Lys Arg Asp Pro  Gln Ile Asn 
    1565                 1570                 1575             


Ile Leu  Leu Leu Pro Leu His  Thr Gly Ser Asn Gly  Leu Thr Ile 
    1580                 1585                 1590             


Ile Glu  Ala Thr His Val Leu  Leu Val Glu Pro Ile  Leu Asn Pro 
    1595                 1600                 1605             


Ala His  Glu Leu Gln Ala Ile  Gly Arg Val His Arg  Ile Gly Gln 
    1610                 1615                 1620             


Thr Lys  Pro Thr Ile Val His  Arg Phe Leu Ile Lys  Ala Thr Ile 
    1625                 1630                 1635             


Glu Glu  Arg Met Gln Ala Met  Leu Lys Thr Ala Glu  Arg Ser His 
    1640                 1645                 1650             


Thr Asn  Ser Ser Ala Lys His  Ser Glu Ala Ser Val  Leu Thr Val 
    1655                 1660                 1665             


Ala Asp  Leu Ala Asp Leu Phe  Thr Lys Glu Thr Glu  Glu Leu Glu 
    1670                 1675                 1680             


<210>  30
<211>  1683
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Ser Arg Arg Lys Arg Ala Pro Pro Val Arg Val Asp Glu Glu 
1               5                   10                  15      


Lys Arg Gln Gln Leu His Trp Asn Met His Glu Asp Arg Arg Asn Glu 
            20                  25                  30          


Pro Ile Ile Ile Ser Asp Asp Asp Glu Gln Pro Cys Pro Gly Ser Asp 
        35                  40                  45              


Thr Ser Ser Ala His Tyr Ile Ile Leu Ser Asp Ser Leu Lys Glu Glu 
    50                  55                  60                  


Val Ala His Arg Asp Lys Lys Arg Cys Ser Lys Val Val Ser Phe Ser 
65                  70                  75                  80  


Lys Pro Ile Glu Lys Glu Glu Thr Val Gly Ile Phe Ser Pro Leu Ser 
                85                  90                  95      


Val Lys Leu Asn Ile Val Ile Ser Pro Tyr His Phe Asp Asn Ser Trp 
            100                 105                 110         


Lys Ala Phe Leu Gly Glu Leu Thr Leu Gln Leu Leu Pro Ala Gln Ser 
        115                 120                 125             


Leu Ile Glu Asn Phe Ser Glu Arg Ser Ile Thr Leu Met Ser Ser Glu 
    130                 135                 140                 


Ser Ser Asn Gln Phe Leu Ile Tyr Val His Ser Lys Gly Glu Asp Val 
145                 150                 155                 160 


Glu Lys Gln Lys Lys Glu Pro Met Ser Ile Cys Asp Lys Gly Ile Leu 
                165                 170                 175     


Val Glu Ser Ser Phe Ser Gly Glu Met Leu Glu Asp Leu Gly Trp Leu 
            180                 185                 190         


Gln Lys Lys Arg Arg Ile Lys Leu Tyr Gln Lys Pro Glu Gly Asn His 
        195                 200                 205             


Ile Ile Lys Val Gly Ile Tyr Leu Leu Glu Ala Gly Leu Ala Lys Leu 
    210                 215                 220                 


Asp Phe Leu Ser Asp Ala Asn Ser Arg Met Lys Lys Phe Asn Gln Leu 
225                 230                 235                 240 


Met Lys Lys Val Met Glu Lys Leu His Asn Ser Ile Ile Pro Asp Val 
                245                 250                 255     


Leu Glu Glu Asp Glu Asp Asp Pro Glu Ser Glu Pro Glu Gly Gln Asp 
            260                 265                 270         


Ile Asp Glu Leu Tyr His Phe Val Lys Gln Thr His Gln Gln Glu Thr 
        275                 280                 285             


Gln Ser Ile Gln Val Asp Val Gln His Pro Ala Leu Ile Pro Val Leu 
    290                 295                 300                 


Arg Pro Tyr Gln Arg Glu Ala Val Asn Trp Met Leu Gln Gln Glu Cys 
305                 310                 315                 320 


Phe Arg Ser Ser Pro Ala Thr Glu Ser Ala Leu His Phe Leu Trp Arg 
                325                 330                 335     


Glu Ile Val Thr Ser Glu Gly Leu Lys Leu Tyr Tyr Asn Pro Tyr Thr 
            340                 345                 350         


Gly Cys Ile Ile Arg Glu Tyr Pro Asn Ser Gly Pro Gln Leu Leu Gly 
        355                 360                 365             


Gly Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Val Glu Val Leu 
    370                 375                 380                 


Ala Leu Ile Leu Thr His Thr Arg Gln Asp Val Lys Gln Asp Ala Leu 
385                 390                 395                 400 


Thr Leu Pro Glu Gly Lys Val Val Asn Tyr Phe Ile Pro Ser His Tyr 
                405                 410                 415     


Phe Gly Gly Lys Leu Lys Lys Thr Glu Ile Gln Asn Ile Glu Phe Glu 
            420                 425                 430         


Pro Lys Glu Lys Val Gln Cys Pro Pro Thr Arg Val Met Ile Leu Thr 
        435                 440                 445             


Ala Val Lys Glu Met Asn Gly Lys Lys Gly Val Ser Ile Leu Ser Ile 
    450                 455                 460                 


Tyr Lys Tyr Val Ser Ser Ile Tyr Arg Tyr Asp Val Gln Arg Asn Arg 
465                 470                 475                 480 


Ser Leu Leu Lys Arg Met Leu Lys Cys Leu Ile Phe Glu Gly Leu Val 
                485                 490                 495     


Lys Gln Ile Lys Gly His Gly Phe Ser Gly Thr Phe Thr Leu Gly Lys 
            500                 505                 510         


Asn Tyr Lys Glu Glu Asp Ile Cys Asp Lys Thr Lys Lys Gln Ala Val 
        515                 520                 525             


Gly Ser Pro Arg Lys Ile Gln Lys Glu Thr Arg Lys Ser Gly Asn Lys 
    530                 535                 540                 


Asp Thr Asp Ser Glu Tyr Leu Pro Ser Asp Thr Ser Asp Asp Asp Asp 
545                 550                 555                 560 


Asp Pro Tyr Tyr Tyr Tyr Tyr Lys Ser Arg Arg Asn Arg Ser Lys Leu 
                565                 570                 575     


Arg Lys Lys Leu Val Pro Ser Thr Lys Lys Gly Lys Ser Gln Pro Phe 
            580                 585                 590         


Ile Asn Pro Asp Ser Gln Gly His Cys Pro Ala Thr Ser Asp Ser Gly 
        595                 600                 605             


Ile Thr Asp Val Ala Met Ser Lys Ser Thr Cys Ile Ser Glu Phe Asn 
    610                 615                 620                 


Gln Glu His Glu Thr Glu Asp Cys Ala Glu Ser Leu Asn His Ala Asp 
625                 630                 635                 640 


Ser Asp Val Pro Pro Ser Asn Thr Met Ser Pro Phe Asn Thr Ser Asp 
                645                 650                 655     


Tyr Arg Phe Glu Cys Ile Cys Gly Glu Leu Asp Gln Ile Asp Arg Lys 
            660                 665                 670         


Pro Arg Val Gln Cys Leu Lys Cys His Leu Trp Gln His Ala Lys Cys 
        675                 680                 685             


Val Asn Tyr Asp Glu Lys Asn Leu Lys Ile Lys Pro Phe Tyr Cys Pro 
    690                 695                 700                 


His Cys Leu Val Ala Met Glu Pro Val Ser Thr Arg Ala Thr Leu Ile 
705                 710                 715                 720 


Ile Ser Pro Ser Ser Ile Cys His Gln Trp Val Asp Glu Ile Asn Arg 
                725                 730                 735     


His Val Arg Ser Ser Ser Leu Arg Val Leu Val Tyr Gln Gly Val Lys 
            740                 745                 750         


Lys Asp Gly Phe Leu Gln Pro His Phe Leu Ala Glu Gln Asp Ile Val 
        755                 760                 765             


Ile Ile Thr Tyr Asp Val Leu Arg Ser Glu Leu Asn Tyr Val Asp Ile 
    770                 775                 780                 


Pro His Ser Asn Ser Glu Asp Gly Arg Arg Leu Arg Asn Gln Lys Arg 
785                 790                 795                 800 


Tyr Met Ala Ile Pro Ser Pro Leu Val Ala Val Glu Trp Trp Arg Ile 
                805                 810                 815     


Cys Leu Asp Glu Ala Gln Met Val Glu Cys Pro Thr Val Lys Ala Ala 
            820                 825                 830         


Glu Met Ala Gln Arg Leu Ser Gly Ile Asn Arg Trp Cys Ile Ser Gly 
        835                 840                 845             


Thr Pro Val Gln Arg Gly Leu Glu Asp Leu Phe Gly Leu Val Val Phe 
    850                 855                 860                 


Leu Gly Ile Glu Pro Tyr Cys Val Lys His Trp Trp Val Arg Leu Leu 
865                 870                 875                 880 


Tyr Arg Pro Tyr Cys Lys Lys Asn Pro Gln His Leu Tyr Ser Phe Ile 
                885                 890                 895     


Ala Lys Ile Leu Trp Arg Ser Ala Lys Lys Asp Val Ile Asp Gln Ile 
            900                 905                 910         


Gln Ile Pro Pro Gln Thr Glu Glu Ile His Trp Leu His Phe Ser Pro 
        915                 920                 925             


Val Glu Arg His Phe Tyr His Arg Gln His Glu Val Cys Cys Gln Asp 
    930                 935                 940                 


Val Val Val Lys Leu Arg Lys Ile Ser Asp Trp Ala Leu Lys Leu Ser 
945                 950                 955                 960 


Ser Leu Asp Arg Arg Thr Val Thr Ser Ile Leu Tyr Pro Leu Leu Arg 
                965                 970                 975     


Leu Arg Gln Ala Cys Cys His Pro Gln Ala Val Arg Gly Glu Phe Leu 
            980                 985                 990         


Pro Leu Gln Lys Ser Thr Met Thr  Met Glu Glu Leu Leu  Thr Ser Leu 
        995                 1000                 1005             


Gln Lys  Lys Cys Gly Thr Glu  Cys Glu Glu Ala His  Arg Gln Leu 
    1010                 1015                 1020             


Val Cys  Ala Leu Asn Gly Leu  Ala Gly Ile His Ile  Ile Lys Gly 
    1025                 1030                 1035             


Glu Tyr  Ala Leu Ala Ala Glu  Leu Tyr Arg Glu Val  Leu Arg Ser 
    1040                 1045                 1050             


Ser Glu  Glu His Lys Gly Lys  Leu Lys Thr Asp Ser  Leu Gln Arg 
    1055                 1060                 1065             


Leu His  Ala Thr His Asn Leu  Met Glu Leu Leu Ile  Ala Arg His 
    1070                 1075                 1080             


Pro Gly  Ile Pro Pro Thr Leu  Arg Asp Gly Arg Leu  Glu Glu Glu 
    1085                 1090                 1095             


Ala Lys  Gln Leu Arg Glu His  Tyr Met Ser Lys Cys  Asn Thr Glu 
    1100                 1105                 1110             


Val Ala  Glu Ala Gln Gln Ala  Leu Tyr Pro Val Gln  Gln Thr Ile 
    1115                 1120                 1125             


His Glu  Leu Gln Arg Lys Ile  His Ser Asn Ser Pro  Trp Trp Leu 
    1130                 1135                 1140             


Asn Val  Ile His Arg Ala Ile  Glu Phe Thr Ile Asp  Glu Glu Leu 
    1145                 1150                 1155             


Val Gln  Arg Val Arg Asn Glu  Ile Thr Ser Asn Tyr  Lys Gln Gln 
    1160                 1165                 1170             


Thr Gly  Lys Leu Ser Met Ser  Glu Lys Phe His Asp  Cys Arg Gly 
    1175                 1180                 1185             


Leu Gln  Phe Leu Leu Thr Thr  Gln Met Glu Glu Leu  Asn Lys Cys 
    1190                 1195                 1200             


Gln Lys  Leu Val Arg Glu Ala  Val Lys Asn Leu Glu  Gly Pro Pro 
    1205                 1210                 1215             


Ser Arg  Asn Val Ile Glu Ser  Ala Thr Val Cys His  Leu Arg Pro 
    1220                 1225                 1230             


Ala Arg  Leu Pro Leu Asn Cys  Cys Val Phe Cys Lys  Ala Asp Glu 
    1235                 1240                 1245             


Leu Phe  Thr Glu Tyr Glu Ser  Lys Leu Phe Ser Asn  Thr Val Lys 
    1250                 1255                 1260             


Gly Gln  Thr Ala Ile Phe Glu  Glu Met Ile Glu Asp  Glu Glu Gly 
    1265                 1270                 1275             


Leu Val  Asp Asp Arg Ala Pro  Thr Thr Thr Arg Gly  Leu Trp Ala 
    1280                 1285                 1290             


Ile Ser  Glu Thr Glu Arg Ser  Met Lys Ala Ile Leu  Ser Phe Ala 
    1295                 1300                 1305             


Lys Ser  His Arg Phe Asp Val  Glu Phe Val Asp Glu  Gly Ser Thr 
    1310                 1315                 1320             


Ser Met  Asp Leu Phe Glu Ala  Trp Lys Lys Glu Tyr  Lys Leu Leu 
    1325                 1330                 1335             


His Glu  Tyr Trp Met Ala Leu  Arg Asn Arg Val Ser  Ala Val Asp 
    1340                 1345                 1350             


Glu Leu  Ala Met Ala Thr Glu  Arg Leu Arg Val Arg  Asp Pro Arg 
    1355                 1360                 1365             


Glu Pro  Lys Pro Asn Pro Pro  Val Leu His Ile Ile  Glu Pro His 
    1370                 1375                 1380             


Glu Val  Glu Gln Asn Arg Ile  Lys Leu Leu Asn Asp  Lys Ala Val 
    1385                 1390                 1395             


Ala Thr  Ser Gln Leu Gln Lys  Lys Leu Gly Gln Leu  Leu Tyr Leu 
    1400                 1405                 1410             


Thr Asn  Leu Glu Lys Ser Gln  Asp Lys Thr Ser Gly  Gly Val Asn 
    1415                 1420                 1425             


Pro Glu  Pro Cys Pro Ile Cys  Ala Arg Gln Leu Gly  Lys Gln Trp 
    1430                 1435                 1440             


Ala Val  Leu Thr Cys Gly His  Cys Phe Cys Asn Glu  Cys Ile Ser 
    1445                 1450                 1455             


Ile Ile  Ile Glu Gln Tyr Ser  Val Gly Ser His Arg  Ser Ser Ile 
    1460                 1465                 1470             


Lys Cys  Ala Ile Cys Arg Gln  Thr Thr Ser His Lys  Glu Ile Ser 
    1475                 1480                 1485             


Tyr Val  Phe Thr Ser Glu Lys  Ala Asn Gln Glu Glu  Asp Ile Pro 
    1490                 1495                 1500             


Val Lys  Gly Ser His Ser Thr  Lys Val Glu Ala Val  Val Arg Thr 
    1505                 1510                 1515             


Leu Met  Lys Ile Gln Leu Arg  Asp Pro Gly Ala Lys  Ala Leu Val 
    1520                 1525                 1530             


Phe Ser  Thr Trp Gln Asp Val  Leu Asp Ile Ile Ser  Lys Ala Leu 
    1535                 1540                 1545             


Thr Asp  Asn Asn Met Glu Phe  Ala Gln Ile Ser Arg  Val Lys Thr 
    1550                 1555                 1560             


Phe Gln  Glu Asn Leu Ser Ala  Phe Lys Arg Asp Pro  Gln Ile Asn 
    1565                 1570                 1575             


Ile Leu  Leu Leu Pro Leu His  Thr Gly Ser Asn Gly  Leu Thr Ile 
    1580                 1585                 1590             


Ile Glu  Ala Thr His Val Leu  Leu Val Glu Pro Ile  Leu Asn Pro 
    1595                 1600                 1605             


Ala His  Glu Leu Gln Ala Ile  Gly Arg Val His Arg  Ile Gly Gln 
    1610                 1615                 1620             


Thr Lys  Pro Thr Ile Val His  Arg Phe Leu Ile Lys  Ala Thr Ile 
    1625                 1630                 1635             


Glu Glu  Arg Met Gln Ala Met  Leu Lys Thr Ala Glu  Arg Ser His 
    1640                 1645                 1650             


Thr Asn  Ser Ser Ala Lys His  Ser Glu Ala Ser Val  Leu Thr Val 
    1655                 1660                 1665             


Ala Asp  Leu Ala Asp Leu Phe  Thr Lys Glu Thr Glu  Glu Leu Glu 
    1670                 1675                 1680             


