                         SEQUENCE LISTING

<110>  Yissum Research Development Company of The Hebrew 
       University of Jerusalem Ltd.
       The University of Western Australia
 
<120>  RESTORATION OF THE CFTR FUNCTION BY SPLICING MODULATION

<130>  YISSUM-0106

<150>  61/704859
<151>  2012-09-24

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  6132
<212>  RNA
<213>  Homo sapiens

<400>  1
aauuggaagc aaaugacauc acagcagguc agagaaaaag gguugagcgg caggcaccca       60

gaguaguagg ucuuuggcau uaggagcuug agcccagacg gcccuagcag ggaccccagc      120

gcccgagaga ccaugcagag gucgccucug gaaaaggcca gcguugucuc caaacuuuuu      180

uucagcugga ccagaccaau uuugaggaaa ggauacagac agcgccugga auugucagac      240

auauaccaaa ucccuucugu ugauucugcu gacaaucuau cugaaaaauu ggaaagagaa      300

ugggauagag agcuggcuuc aaagaaaaau ccuaaacuca uuaaugcccu ucggcgaugu      360

uuuuucugga gauuuauguu cuauggaauc uuuuuauauu uaggggaagu caccaaagca      420

guacagccuc ucuuacuggg aagaaucaua gcuuccuaug acccggauaa caaggaggaa      480

cgcucuaucg cgauuuaucu aggcauaggc uuaugccuuc ucuuuauugu gaggacacug      540

cuccuacacc cagccauuuu uggccuucau cacauuggaa ugcagaugag aauagcuaug      600

uuuaguuuga uuuauaagaa gacuuuaaag cugucaagcc guguucuaga uaaaauaagu      660

auuggacaac uuguuagucu ccuuuccaac aaccugaaca aauuugauga aggacuugca      720

uuggcacauu ucguguggau cgcuccuuug caaguggcac uccucauggg gcuaaucugg      780

gaguuguuac aggcgucugc cuucugugga cuugguuucc ugauaguccu ugcccuuuuu      840

caggcugggc uagggagaau gaugaugaag uacagagauc agagagcugg gaagaucagu      900

gaaagacuug ugauuaccuc agaaaugauu gaaaauaucc aaucuguuaa ggcauacugc      960

ugggaagaag caauggaaaa aaugauugaa aacuuaagac aaacagaacu gaaacugacu     1020

cggaaggcag ccuaugugag auacuucaau agcucagccu ucuucuucuc aggguucuuu     1080

gugguguuuu uaucugugcu ucccuaugca cuaaucaaag gaaucauccu ccggaaaaua     1140

uucaccacca ucucauucug cauuguucug cgcauggcgg ucacucggca auuucccugg     1200

gcuguacaaa caugguauga cucucuugga gcaauaaaca aaauacagga uuucuuacaa     1260

aagcaagaau auaagacauu ggaauauaac uuaacgacua cagaaguagu gauggagaau     1320

guaacagccu ucugggagga gggauuuggg gaauuauuug agaaagcaaa acaaaacaau     1380

aacaauagaa aaacuucuaa uggugaugac agccucuucu ucaguaauuu cucacuucuu     1440

gguacuccug uccugaaaga uauuaauuuc aagauagaaa gaggacaguu guuggcgguu     1500

gcuggaucca cuggagcagg caagacuuca cuucuaaugg ugauuauggg agaacuggag     1560

ccuucagagg guaaaauuaa gcacagugga agaauuucau ucuguucuca guuuuccugg     1620

auuaugccug gcaccauuaa agaaaauauc aucuuuggug uuuccuauga ugaauauaga     1680

uacagaagcg ucaucaaagc augccaacua gaagaggaca ucuccaaguu ugcagagaaa     1740

gacaauauag uucuuggaga agguggaauc acacugagug gaggucaacg agcaagaauu     1800

ucuuuagcaa gagcaguaua caaagaugcu gauuuguauu uauuagacuc uccuuuugga     1860

uaccuagaug uuuuaacaga aaaagaaaua uuugaaagcu gugucuguaa acugauggcu     1920

aacaaaacua ggauuuuggu cacuucuaaa auggaacauu uaaagaaagc ugacaaaaua     1980

uuaauuuugc augaagguag cagcuauuuu uaugggacau uuucagaacu ccaaaaucua     2040

cagccagacu uuagcucaaa acucauggga ugugauucuu ucgaccaauu uagugcagaa     2100

agaagaaauu caauccuaac ugagaccuua caccguuucu cauuagaagg agaugcuccu     2160

gucuccugga cagaaacaaa aaaacaaucu uuuaaacaga cuggagaguu uggggaaaaa     2220

aggaagaauu cuauucucaa uccaaucaac ucuauacgaa aauuuuccau ugugcaaaag     2280

acucccuuac aaaugaaugg caucgaagag gauucugaug agccuuuaga gagaaggcug     2340

uccuuaguac cagauucuga gcagggagag gcgauacugc cucgcaucag cgugaucagc     2400

acuggcccca cgcuucaggc acgaaggagg cagucugucc ugaaccugau gacacacuca     2460

guuaaccaag gucagaacau ucaccgaaag acaacagcau ccacacgaaa agugucacug     2520

gccccucagg caaacuugac ugaacuggau auauauucaa gaagguuauc ucaagaaacu     2580

ggcuuggaaa uaagugaaga aauuaacgaa gaagacuuaa aggagugcuu uuuugaugau     2640

auggagagca uaccagcagu gacuacaugg aacacauacc uucgauauau uacuguccac     2700

aagagcuuaa uuuuugugcu aauuuggugc uuaguaauuu uucuggcaga gguggcugcu     2760

ucuuugguug ugcuguggcu ccuuggaaac acuccucuuc aagacaaagg gaauaguacu     2820

cauaguagaa auaacagcua ugcagugauu aucaccagca ccaguucgua uuauguguuu     2880

uacauuuacg ugggaguagc cgacacuuug cuugcuaugg gauucuucag aggucuacca     2940

cuggugcaua cucuaaucac agugucgaaa auuuuacacc acaaaauguu acauucuguu     3000

cuucaagcac cuaugucaac ccucaacacg uugaaagcag gugggauucu uaauagauuc     3060

uccaaagaua uagcaauuuu ggaugaccuu cugccucuua ccauauuuga cuucauccag     3120

uuguuauuaa uugugauugg agcuauagca guugucgcag uuuuacaacc cuacaucuuu     3180

guugcaacag ugccagugau aguggcuuuu auuauguuga gagcauauuu ccuccaaacc     3240

ucacagcaac ucaaacaacu ggaaucugaa ggcaggaguc caauuuucac ucaucuuguu     3300

acaagcuuaa aaggacuaug gacacuucgu gccuucggac ggcagccuua cuuugaaacu     3360

cuguuccaca aagcucugaa uuuacauacu gccaacuggu ucuuguaccu gucaacacug     3420

cgcugguucc aaaugagaau agaaaugauu uuugucaucu ucuucauugc uguuaccuuc     3480

auuuccauuu uaacaacagg agaaggagaa ggaagaguug guauuauccu gacuuuagcc     3540

augaauauca ugaguacauu gcagugggcu guaaacucca gcauagaugu ggauagcuug     3600

augcgaucug ugagccgagu cuuuaaguuc auugacaugc caacagaagg uaaaccuacc     3660

aagucaacca aaccauacaa gaauggccaa cucucgaaag uuaugauuau ugagaauuca     3720

cacgugaaga aagaugacau cuggcccuca gggggccaaa ugacugucaa agaucucaca     3780

gcaaaauaca cagaaggugg aaaugccaua uuagagaaca uuuccuucuc aauaaguccu     3840

ggccagaggg ugggccucuu gggaagaacu ggaucaggga agaguacuuu guuaucagcu     3900

uuuuugagac uacugaacac ugaaggagaa auccagaucg augguguguc uugggauuca     3960

auaacuuugc aacaguggag gaaagccuuu ggagugauac cacagaaagu auuuauuuuu     4020

ucuggaacau uuagaaaaaa cuuggauccc uaugaacagu ggagugauca agaaauaugg     4080

aaaguugcag augagguugg gcucagaucu gugauagaac aguuuccugg gaagcuugac     4140

uuuguccuug uggauggggg cuguguccua agccauggcc acaagcaguu gaugugcuug     4200

gcuagaucug uucucaguaa ggcgaagauc uugcugcuug augaacccag ugcucauuug     4260

gauccaguaa cauaccaaau aauuagaaga acucuaaaac aagcauuugc ugauugcaca     4320

guaauucucu gugaacacag gauagaagca augcuggaau gccaacaauu uuuggucaua     4380

gaagagaaca aagugcggca guacgauucc auccagaaac ugcugaacga gaggagccuc     4440

uuccggcaag ccaucagccc cuccgacagg gugaagcucu uuccccaccg gaacucaagc     4500

aagugcaagu cuaagcccca gauugcugcu cugaaagagg agacagaaga agaggugcaa     4560

gauacaaggc uuuagagagc agcauaaaug uugacauggg acauuugcuc auggaauugg     4620

agcucguggg acagucaccu cauggaauug gagcucgugg aacaguuacc ucugccucag     4680

aaaacaagga ugaauuaagu uuuuuuuuaa aaaagaaaca uuugguaagg ggaauugagg     4740

acacugauau gggucuugau aaauggcuuc cuggcaauag ucaaauugug ugaaagguac     4800

uucaaauccu ugaagauuua ccacuugugu uuugcaagcc agauuuuccu gaaaacccuu     4860

gccaugugcu aguaauugga aaggcagcuc uaaaugucaa ucagccuagu ugaucagcuu     4920

auugucuagu gaaacucguu aauuuguagu guuggagaag aacugaaauc auacuucuua     4980

ggguuaugau uaaguaauga uaacuggaaa cuucagcggu uuauauaagc uuguauuccu     5040

uuuucucucc ucuccccaug auguuuagaa acacaacuau auuguuugcu aagcauucca     5100

acuaucucau uuccaagcaa guauuagaau accacaggaa ccacaagacu gcacaucaaa     5160

auaugcccca uucaacaucu agugagcagu caggaaagag aacuuccaga uccuggaaau     5220

caggguuagu auuguccagg ucuaccaaaa aucucaauau uucagauaau cacaauacau     5280

cccuuaccug ggaaagggcu guuauaaucu uucacagggg acaggauggu ucccuugaug     5340

aagaaguuga uaugccuuuu cccaacucca gaaagugaca agcucacaga ccuuugaacu     5400

agaguuuagc uggaaaagua uguuagugca aauugucaca ggacagcccu ucuuuccaca     5460

gaagcuccag guagagggug uguaaguaga uaggccaugg gcacuguggg uagacacaca     5520

ugaaguccaa gcauuuagau guauagguug auggugguau guuuucaggc uagauguaug     5580

uacuucaugc ugucuacacu aagagagaau gagagacaca cugaagaagc accaaucaug     5640

aauuaguuuu auaugcuucu guuuuauaau uuugugaagc aaaauuuuuu cucuaggaaa     5700

uauuuauuuu aauaauguuu caaacauaua uaacaaugcu guauuuuaaa agaaugauua     5760

ugaauuacau uuguauaaaa uaauuuuuau auuugaaaua uugacuuuuu auggcacuag     5820

uauuucuaug aaauauuaug uuaaaacugg gacaggggag aaccuagggu gauauuaacc     5880

aggggccaug aaucaccuuu uggucuggag ggaagccuug gggcugaugc aguuguugcc     5940

cacagcugua ugauucccag ccagcacagc cucuuagaug caguucugaa gaagauggua     6000

ccaccagucu gacuguuucc aucaagggua cacugccuuc ucaacuccaa acugacucuu     6060

aagaagacug cauuauauuu auuacuguaa gaaaauauca cuugucaaua aaauccauac     6120

auuuguguga aa                                                         6132


<210>  2
<211>  983
<212>  RNA
<213>  Homo sapiens

<400>  2
cagcuuugaa agaggaggau uauaaaaucu aucucauguu aaugcugaag auuaaauaau       60

aguguuuaug uaccccgcuu auaggagaag agggugugug ugugugugug ugugugugug      120

uguguaugug uauguauaca uguauguauu cagucuuuac ugaaauuaaa aaaucuuuaa      180

cuugauaaug ggcaaauauc uuaguuuuag aucauguccu cuagaaaccg uaugcuauau      240

aauuauguac uauaaaguaa uaauguauac aguguaaugg aucaugggcc augugcuuuu      300

caaacuaauu guacauaaaa caagcaucua uugaaaauau cugacaaacu caucuuuuau      360

uuuugaugug ugugugugug uguguguguu uuuuuaacag ggauuugggg aauuauuuga      420

gaaagcaaaa caaaacaaua acaauagaaa aacuucuaau ggugaugaca gccucuucuu      480

caguaauuuc ucacuucuug guacuccugu ccugaaagau auuaauuuca agauagaaag      540

aggacaguug uuggcgguug cuggauccac uggagcaggc aagguaguuc uuuuguucuu      600

cacuauuaag aacuuaauuu gguguccaug ucucuuuuuu uuucuaguuu guagugcugg      660

aagguauuuu uggagaaauu cuuacaugag cauuaggaga auguaugggu guagugucuu      720

guauaauaga aauuguucca cugauaauuu acucuaguuu uuuauuuccu cauauuauuu      780

ucaguggcuu uuucuuccac aucuuuauau uuugcaccac auucaacacu guaucuugca      840

cauggcgagc auucaauaac uuuauugaau aaacaaauca uccauuuuau ccauucuuaa      900

ccagaacaga cauuuuuuca gagcuggucc aggaaaauca ugacuuacau uuugccuuag      960

uaaccacaua aacaaaaggu cuc                                              983


<210>  3
<211>  122
<212>  RNA
<213>  Homo sapiens

<400>  3
uuguggaucu aaauuucagu ugacuuguca ucuugauuuc uggagaccac aagguaauga       60

aaaauaauua caagagucuu ccaucuguug caguauuaaa auggcgagua agacacccug      120

aa                                                                     122


<210>  4
<211>  132
<212>  RNA
<213>  Homo sapiens

<400>  4
ucaccuugug gaucuaaauu ucaguugacu ugucaucuug auuucuggag accacaaggu       60

aaugaaaaau aauuacaaga gucuuccauc uguugcagua uuaaaauggc gaguaagaca      120

cccugaaagg aa                                                          132


<210>  5
<211>  84
<212>  RNA
<213>  Homo sapiens

<400>  5
uugacuuguc aucuugauuu cuggagacca caagguaaug aaaaauaauu acaagagucu       60

uccaucuguu gcaguauuaa aaug                                              84


<210>  6
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense Oligonucleotide

<400>  6
aaaucaagau gacaagucaa cugaa                                             25


<210>  7
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense Oligonucleotide

<400>  7
cuuguggucu ccagaaauca agaug                                             25


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense Oligonucleotide

<400>  8
aacagaugga agacucuugu aauua                                             25


<210>  9
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense Oligonucleotide

<400>  9
ucaggguguc uuacucacca uuuua                                             25


<210>  10
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense Oligonucleotide

<400>  10
cuagaaaaaa aaagagacau gg                                                22


<210>  11
<211>  6216
<212>  RNA
<213>  Homo sapiens

<400>  11
aauuggaagc aaaugacauc acagcagguc agagaaaaag gguugagcgg caggcaccca       60

gaguaguagg ucuuuggcau uaggagcuug agcccagacg gcccuagcag ggaccccagc      120

gcccgagaga ccaugcagag gucgccucug gaaaaggcca gcguugucuc caaacuuuuu      180

uucagcugga ccagaccaau uuugaggaaa ggauacagac agcgccugga auugucagac      240

auauaccaaa ucccuucugu ugauucugcu gacaaucuau cugaaaaauu ggaaagagaa      300

ugggauagag agcuggcuuc aaagaaaaau ccuaaacuca uuaaugcccu ucggcgaugu      360

uuuuucugga gauuuauguu cuauggaauc uuuuuauauu uaggggaagu caccaaagca      420

guacagccuc ucuuacuggg aagaaucaua gcuuccuaug acccggauaa caaggaggaa      480

cgcucuaucg cgauuuaucu aggcauaggc uuaugccuuc ucuuuauugu gaggacacug      540

cuccuacacc cagccauuuu uggccuucau cacauuggaa ugcagaugag aauagcuaug      600

uuuaguuuga uuuauaagaa gacuuuaaag cugucaagcc guguucuaga uaaaauaagu      660

auuggacaac uuguuagucu ccuuuccaac aaccugaaca aauuugauga aggacuugca      720

uuggcacauu ucguguggau cgcuccuuug caaguggcac uccucauggg gcuaaucugg      780

gaguuguuac aggcgucugc cuucugugga cuugguuucc ugauaguccu ugcccuuuuu      840

caggcugggc uagggagaau gaugaugaag uacagagauc agagagcugg gaagaucagu      900

gaaagacuug ugauuaccuc agaaaugauu gaaaauaucc aaucuguuaa ggcauacugc      960

ugggaagaag caauggaaaa aaugauugaa aacuuaagac aaacagaacu gaaacugacu     1020

cggaaggcag ccuaugugag auacuucaau agcucagccu ucuucuucuc aggguucuuu     1080

gugguguuuu uaucugugcu ucccuaugca cuaaucaaag gaaucauccu ccggaaaaua     1140

uucaccacca ucucauucug cauuguucug cgcauggcgg ucacucggca auuucccugg     1200

gcuguacaaa caugguauga cucucuugga gcaauaaaca aaauacagga uuucuuacaa     1260

aagcaagaau auaagacauu ggaauauaac uuaacgacua cagaaguagu gauggagaau     1320

guaacagccu ucugggagga gggauuuggg gaauuauuug agaaagcaaa acaaaacaau     1380

aacaauagaa aaacuucuaa uggugaugac agccucuucu ucaguaauuu cucacuucuu     1440

gguacuccug uccugaaaga uauuaauuuc aagauagaaa gaggacaguu guuggcgguu     1500

gcuggaucca cuggagcagg caagacuuca cuucuaaugg ugauuauggg agaacuggag     1560

ccuucagagg guaaaauuaa gcacagugga agaauuucau ucuguucuca guuuuccugg     1620

auuaugccug gcaccauuaa agaaaauauc aucuuuggug uuuccuauga ugaauauaga     1680

uacagaagcg ucaucaaagc augccaacua gaagaggaca ucuccaaguu ugcagagaaa     1740

gacaauauag uucuuggaga agguggaauc acacugagug gaggucaacg agcaagaauu     1800

ucuuuagcaa gagcaguaua caaagaugcu gauuuguauu uauuagacuc uccuuuugga     1860

uaccuagaug uuuuaacaga aaaagaaaua uuugaaagcu gugucuguaa acugauggcu     1920

aacaaaacua ggauuuuggu cacuucuaaa auggaacauu uaaagaaagc ugacaaaaua     1980

uuaauuuugc augaagguag cagcuauuuu uaugggacau uuucagaacu ccaaaaucua     2040

cagccagacu uuagcucaaa acucauggga ugugauucuu ucgaccaauu uagugcagaa     2100

agaagaaauu caauccuaac ugagaccuua caccguuucu cauuagaagg agaugcuccu     2160

gucuccugga cagaaacaaa aaaacaaucu uuuaaacaga cuggagaguu uggggaaaaa     2220

aggaagaauu cuauucucaa uccaaucaac ucuauacgaa aauuuuccau ugugcaaaag     2280

acucccuuac aaaugaaugg caucgaagag gauucugaug agccuuuaga gagaaggcug     2340

uccuuaguac cagauucuga gcagggagag gcgauacugc cucgcaucag cgugaucagc     2400

acuggcccca cgcuucaggc acgaaggagg cagucugucc ugaaccugau gacacacuca     2460

guuaaccaag gucagaacau ucaccgaaag acaacagcau ccacacgaaa agugucacug     2520

gccccucagg caaacuugac ugaacuggau auauauucaa gaagguuauc ucaagaaacu     2580

ggcuuggaaa uaagugaaga aauuaacgaa gaagacuuaa aggagugcuu uuuugaugau     2640

auggagagca uaccagcagu gacuacaugg aacacauacc uucgauauau uacuguccac     2700

aagagcuuaa uuuuugugcu aauuuggugc uuaguaauuu uucuggcaga gguggcugcu     2760

ucuuugguug ugcuguggcu ccuuggaaac acuccucuuc aagacaaagg gaauaguacu     2820

cauaguagaa auaacagcua ugcagugauu aucaccagca ccaguucgua uuauguguuu     2880

uacauuuacg ugggaguagc cgacacuuug cuugcuaugg gauucuucag aggucuacca     2940

cuggugcaua cucuaaucac agugucgaaa auuuuacacc acaaaauguu acauucuguu     3000

cuucaagcac cuaugucaac ccucaacacg uugaaagcag gugggauucu uaauagauuc     3060

uccaaagaua uagcaauuuu ggaugaccuu cugccucuua ccauauuuga cuucauccag     3120

uuguuauuaa uugugauugg agcuauagca guugucgcag uuuuacaacc cuacaucuuu     3180

guugcaacag ugccagugau aguggcuuuu auuauguuga gagcauauuu ccuccaaacc     3240

ucacagcaac ucaaacaacu ggaaucugaa ggcaggaguc caauuuucac ucaucuuguu     3300

acaagcuuaa aaggacuaug gacacuucgu gccuucggac ggcagccuua cuuugaaacu     3360

cuguuccaca aagcucugaa uuuacauacu gccaacuggu ucuuguaccu gucaacacug     3420

cgcugguucc aaaugagaau agaaaugauu uuugucaucu ucuucauugc uguuaccuuc     3480

auuuccauuu uaacaacagg agaaggagaa ggaagaguug guauuauccu gacuuuagcc     3540

augaauauca ugaguacauu gcagugggcu guaaacucca gcauagaugu ggauagcuug     3600

augcgaucug ugagccgagu cuuuaaguuc auugacaugc caacagaagg uaaaccuacc     3660

aagucaacca aaccauacaa gaauggccaa cucucgaaag uuaugauuau ugagaauuca     3720

cacgugaaga aagaugacau cuggcccuca gggggccaaa ugacugucaa agaucucaca     3780

gcaaaauaca cagaaggugg aaaugccaua uuagagaaca uuuccuucuc aauaaguccu     3840

ggccagaggu ugacuuguca ucuugauuuc uggagaccac aagguaauga aaaauaauua     3900

caagagucuu ccaucuguug caguauuaaa auggugggcc ucuugggaag aacuggauca     3960

gggaagagua cuuuguuauc agcuuuuuug agacuacuga acacugaagg agaaauccag     4020

aucgauggug ugucuuggga uucaauaacu uugcaacagu ggaggaaagc cuuuggagug     4080

auaccacaga aaguauuuau uuuuucugga acauuuagaa aaaacuugga ucccuaugaa     4140

caguggagug aucaagaaau auggaaaguu gcagaugagg uugggcucag aucugugaua     4200

gaacaguuuc cugggaagcu ugacuuuguc cuuguggaug ggggcugugu ccuaagccau     4260

ggccacaagc aguugaugug cuuggcuaga ucuguucuca guaaggcgaa gaucuugcug     4320

cuugaugaac ccagugcuca uuuggaucca guaacauacc aaauaauuag aagaacucua     4380

aaacaagcau uugcugauug cacaguaauu cucugugaac acaggauaga agcaaugcug     4440

gaaugccaac aauuuuuggu cauagaagag aacaaagugc ggcaguacga uuccauccag     4500

aaacugcuga acgagaggag ccucuuccgg caagccauca gccccuccga cagggugaag     4560

cucuuucccc accggaacuc aagcaagugc aagucuaagc cccagauugc ugcucugaaa     4620

gaggagacag aagaagaggu gcaagauaca aggcuuuaga gagcagcaua aauguugaca     4680

ugggacauuu gcucauggaa uuggagcucg ugggacaguc accucaugga auuggagcuc     4740

guggaacagu uaccucugcc ucagaaaaca aggaugaauu aaguuuuuuu uuaaaaaaga     4800

aacauuuggu aaggggaauu gaggacacug auaugggucu ugauaaaugg cuuccuggca     4860

auagucaaau ugugugaaag guacuucaaa uccuugaaga uuuaccacuu guguuuugca     4920

agccagauuu uccugaaaac ccuugccaug ugcuaguaau uggaaaggca gcucuaaaug     4980

ucaaucagcc uaguugauca gcuuauuguc uagugaaacu cguuaauuug uaguguugga     5040

gaagaacuga aaucauacuu cuuaggguua ugauuaagua augauaacug gaaacuucag     5100

cgguuuauau aagcuuguau uccuuuuucu cuccucuccc caugauguuu agaaacacaa     5160

cuauauuguu ugcuaagcau uccaacuauc ucauuuccaa gcaaguauua gaauaccaca     5220

ggaaccacaa gacugcacau caaaauaugc cccauucaac aucuagugag cagucaggaa     5280

agagaacuuc cagauccugg aaaucagggu uaguauuguc caggucuacc aaaaaucuca     5340

auauuucaga uaaucacaau acaucccuua ccugggaaag ggcuguuaua aucuuucaca     5400

ggggacagga ugguucccuu gaugaagaag uugauaugcc uuuucccaac uccagaaagu     5460

gacaagcuca cagaccuuug aacuagaguu uagcuggaaa aguauguuag ugcaaauugu     5520

cacaggacag cccuucuuuc cacagaagcu ccagguagag gguguguaag uagauaggcc     5580

augggcacug uggguagaca cacaugaagu ccaagcauuu agauguauag guugauggug     5640

guauguuuuc aggcuagaug uauguacuuc augcugucua cacuaagaga gaaugagaga     5700

cacacugaag aagcaccaau caugaauuag uuuuauaugc uucuguuuua uaauuuugug     5760

aagcaaaauu uuuucucuag gaaauauuua uuuuaauaau guuucaaaca uauauaacaa     5820

ugcuguauuu uaaaagaaug auuaugaauu acauuuguau aaaauaauuu uuauauuuga     5880

aauauugacu uuuuauggca cuaguauuuc uaugaaauau uauguuaaaa cugggacagg     5940

ggagaaccua gggugauauu aaccaggggc caugaaucac cuuuuggucu ggagggaagc     6000

cuuggggcug augcaguugu ugcccacagc uguaugauuc ccagccagca cagccucuua     6060

gaugcaguuc ugaagaagau gguaccacca gucugacugu uuccaucaag gguacacugc     6120

cuucucaacu ccaaacugac ucuuaagaag acugcauuau auuuauuacu guaagaaaau     6180

aucacuuguc aauaaaaucc auacauuugu gugaaa                               6216


<210>  12
<211>  5949
<212>  RNA
<213>  Homo sapiens

<400>  12
aauuggaagc aaaugacauc acagcagguc agagaaaaag gguugagcgg caggcaccca       60

gaguaguagg ucuuuggcau uaggagcuug agcccagacg gcccuagcag ggaccccagc      120

gcccgagaga ccaugcagag gucgccucug gaaaaggcca gcguugucuc caaacuuuuu      180

uucagcugga ccagaccaau uuugaggaaa ggauacagac agcgccugga auugucagac      240

auauaccaaa ucccuucugu ugauucugcu gacaaucuau cugaaaaauu ggaaagagaa      300

ugggauagag agcuggcuuc aaagaaaaau ccuaaacuca uuaaugcccu ucggcgaugu      360

uuuuucugga gauuuauguu cuauggaauc uuuuuauauu uaggggaagu caccaaagca      420

guacagccuc ucuuacuggg aagaaucaua gcuuccuaug acccggauaa caaggaggaa      480

cgcucuaucg cgauuuaucu aggcauaggc uuaugccuuc ucuuuauugu gaggacacug      540

cuccuacacc cagccauuuu uggccuucau cacauuggaa ugcagaugag aauagcuaug      600

uuuaguuuga uuuauaagaa gacuuuaaag cugucaagcc guguucuaga uaaaauaagu      660

auuggacaac uuguuagucu ccuuuccaac aaccugaaca aauuugauga aggacuugca      720

uuggcacauu ucguguggau cgcuccuuug caaguggcac uccucauggg gcuaaucugg      780

gaguuguuac aggcgucugc cuucugugga cuugguuucc ugauaguccu ugcccuuuuu      840

caggcugggc uagggagaau gaugaugaag uacagagauc agagagcugg gaagaucagu      900

gaaagacuug ugauuaccuc agaaaugauu gaaaauaucc aaucuguuaa ggcauacugc      960

ugggaagaag caauggaaaa aaugauugaa aacuuaagac aaacagaacu gaaacugacu     1020

cggaaggcag ccuaugugag auacuucaau agcucagccu ucuucuucuc aggguucuuu     1080

gugguguuuu uaucugugcu ucccuaugca cuaaucaaag gaaucauccu ccggaaaaua     1140

uucaccacca ucucauucug cauuguucug cgcauggcgg ucacucggca auuucccugg     1200

gcuguacaaa caugguauga cucucuugga gcaauaaaca aaauacagga uuucuuacaa     1260

aagcaagaau auaagacauu ggaauauaac uuaacgacua cagaaguagu gauggagaau     1320

guaacagccu ucugggagga gacuucacuu cuaaugguga uuaugggaga acuggagccu     1380

ucagagggua aaauuaagca caguggaaga auuucauucu guucucaguu uuccuggauu     1440

augccuggca ccauuaaaga aaauaucauc uuugguguuu ccuaugauga auauagauac     1500

agaagcguca ucaaagcaug ccaacuagaa gaggacaucu ccaaguuugc agagaaagac     1560

aauauaguuc uuggagaagg uggaaucaca cugaguggag gucaacgagc aagaauuucu     1620

uuagcaagag caguauacaa agaugcugau uuguauuuau uagacucucc uuuuggauac     1680

cuagauguuu uaacagaaaa agaaauauuu gaaagcugug ucuguaaacu gauggcuaac     1740

aaaacuagga uuuuggucac uucuaaaaug gaacauuuaa agaaagcuga caaaauauua     1800

auuuugcaug aagguagcag cuauuuuuau gggacauuuu cagaacucca aaaucuacag     1860

ccagacuuua gcucaaaacu caugggaugu gauucuuucg accaauuuag ugcagaaaga     1920

agaaauucaa uccuaacuga gaccuuacac cguuucucau uagaaggaga ugcuccuguc     1980

uccuggacag aaacaaaaaa acaaucuuuu aaacagacug gagaguuugg ggaaaaaagg     2040

aagaauucua uucucaaucc aaucaacucu auacgaaaau uuuccauugu gcaaaagacu     2100

cccuuacaaa ugaauggcau cgaagaggau ucugaugagc cuuuagagag aaggcugucc     2160

uuaguaccag auucugagca gggagaggcg auacugccuc gcaucagcgu gaucagcacu     2220

ggccccacgc uucaggcacg aaggaggcag ucuguccuga accugaugac acacucaguu     2280

aaccaagguc agaacauuca ccgaaagaca acagcaucca cacgaaaagu gucacuggcc     2340

ccucaggcaa acuugacuga acuggauaua uauucaagaa gguuaucuca agaaacuggc     2400

uuggaaauaa gugaagaaau uaacgaagaa gacuuaaagg agugcuuuuu ugaugauaug     2460

gagagcauac cagcagugac uacauggaac acauaccuuc gauauauuac uguccacaag     2520

agcuuaauuu uugugcuaau uuggugcuua guaauuuuuc uggcagaggu ggcugcuucu     2580

uugguugugc uguggcuccu uggaaacacu ccucuucaag acaaagggaa uaguacucau     2640

aguagaaaua acagcuaugc agugauuauc accagcacca guucguauua uguguuuuac     2700

auuuacgugg gaguagccga cacuuugcuu gcuaugggau ucuucagagg ucuaccacug     2760

gugcauacuc uaaucacagu gucgaaaauu uuacaccaca aaauguuaca uucuguucuu     2820

caagcaccua ugucaacccu caacacguug aaagcaggug ggauucuuaa uagauucucc     2880

aaagauauag caauuuugga ugaccuucug ccucuuacca uauuugacuu cauccaguug     2940

uuauuaauug ugauuggagc uauagcaguu gucgcaguuu uacaacccua caucuuuguu     3000

gcaacagugc cagugauagu ggcuuuuauu auguugagag cauauuuccu ccaaaccuca     3060

cagcaacuca aacaacugga aucugaaggc aggaguccaa uuuucacuca ucuuguuaca     3120

agcuuaaaag gacuauggac acuucgugcc uucggacggc agccuuacuu ugaaacucug     3180

uuccacaaag cucugaauuu acauacugcc aacugguucu uguaccuguc aacacugcgc     3240

ugguuccaaa ugagaauaga aaugauuuuu gucaucuucu ucauugcugu uaccuucauu     3300

uccauuuuaa caacaggaga aggagaagga agaguuggua uuauccugac uuuagccaug     3360

aauaucauga guacauugca gugggcugua aacuccagca uagaugugga uagcuugaug     3420

cgaucuguga gccgagucuu uaaguucauu gacaugccaa cagaagguaa accuaccaag     3480

ucaaccaaac cauacaagaa uggccaacuc ucgaaaguua ugauuauuga gaauucacac     3540

gugaagaaag augacaucug gcccucaggg ggccaaauga cugucaaaga ucucacagca     3600

aaauacacag aagguggaaa ugccauauua gagaacauuu ccuucucaau aaguccuggc     3660

cagagggugg gccucuuggg aagaacugga ucagggaaga guacuuuguu aucagcuuuu     3720

uugagacuac ugaacacuga aggagaaauc cagaucgaug gugugucuug ggauucaaua     3780

acuuugcaac aguggaggaa agccuuugga gugauaccac agaaaguauu uauuuuuucu     3840

ggaacauuua gaaaaaacuu ggaucccuau gaacagugga gugaucaaga aauauggaaa     3900

guugcagaug agguugggcu cagaucugug auagaacagu uuccugggaa gcuugacuuu     3960

guccuugugg augggggcug uguccuaagc cauggccaca agcaguugau gugcuuggcu     4020

agaucuguuc ucaguaaggc gaagaucuug cugcuugaug aacccagugc ucauuuggau     4080

ccaguaacau accaaauaau uagaagaacu cuaaaacaag cauuugcuga uugcacagua     4140

auucucugug aacacaggau agaagcaaug cuggaaugcc aacaauuuuu ggucauagaa     4200

gagaacaaag ugcggcagua cgauuccauc cagaaacugc ugaacgagag gagccucuuc     4260

cggcaagcca ucagccccuc cgacagggug aagcucuuuc cccaccggaa cucaagcaag     4320

ugcaagucua agccccagau ugcugcucug aaagaggaga cagaagaaga ggugcaagau     4380

acaaggcuuu agagagcagc auaaauguug acaugggaca uuugcucaug gaauuggagc     4440

ucgugggaca gucaccucau ggaauuggag cucguggaac aguuaccucu gccucagaaa     4500

acaaggauga auuaaguuuu uuuuuaaaaa agaaacauuu gguaagggga auugaggaca     4560

cugauauggg ucuugauaaa uggcuuccug gcaauaguca aauuguguga aagguacuuc     4620

aaauccuuga agauuuacca cuuguguuuu gcaagccaga uuuuccugaa aacccuugcc     4680

augugcuagu aauuggaaag gcagcucuaa augucaauca gccuaguuga ucagcuuauu     4740

gucuagugaa acucguuaau uuguaguguu ggagaagaac ugaaaucaua cuucuuaggg     4800

uuaugauuaa guaaugauaa cuggaaacuu cagcgguuua uauaagcuug uauuccuuuu     4860

ucucuccucu ccccaugaug uuuagaaaca caacuauauu guuugcuaag cauuccaacu     4920

aucucauuuc caagcaagua uuagaauacc acaggaacca caagacugca caucaaaaua     4980

ugccccauuc aacaucuagu gagcagucag gaaagagaac uuccagaucc uggaaaucag     5040

gguuaguauu guccaggucu accaaaaauc ucaauauuuc agauaaucac aauacauccc     5100

uuaccuggga aagggcuguu auaaucuuuc acaggggaca ggaugguucc cuugaugaag     5160

aaguugauau gccuuuuccc aacuccagaa agugacaagc ucacagaccu uugaacuaga     5220

guuuagcugg aaaaguaugu uagugcaaau ugucacagga cagcccuucu uuccacagaa     5280

gcuccaggua gagggugugu aaguagauag gccaugggca cuguggguag acacacauga     5340

aguccaagca uuuagaugua uagguugaug gugguauguu uucaggcuag auguauguac     5400

uucaugcugu cuacacuaag agagaaugag agacacacug aagaagcacc aaucaugaau     5460

uaguuuuaua ugcuucuguu uuauaauuuu gugaagcaaa auuuuuucuc uaggaaauau     5520

uuauuuuaau aauguuucaa acauauauaa caaugcugua uuuuaaaaga augauuauga     5580

auuacauuug uauaaaauaa uuuuuauauu ugaaauauug acuuuuuaug gcacuaguau     5640

uucuaugaaa uauuauguua aaacugggac aggggagaac cuagggugau auuaaccagg     5700

ggccaugaau caccuuuugg ucuggaggga agccuugggg cugaugcagu uguugcccac     5760

agcuguauga uucccagcca gcacagccuc uuagaugcag uucugaagaa gaugguacca     5820

ccagucugac uguuuccauc aaggguacac ugccuucuca acuccaaacu gacucuuaag     5880

aagacugcau uauauuuauu acuguaagaa aauaucacuu gucaauaaaa uccauacauu     5940

ugugugaaa                                                             5949


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense Oligonucleotide

<400>  13
cuugugaaac uuacugauua ucagg                                             25


<210>  14
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense Oligonucleotide

<400>  14
ccucuuaccu caguuacaau uuaua                                             25


