                         SEQUENCE LISTING

<110>  Covagen AG
 
<120>  Novel IL-17 binding molecules and medical uses thereof

<130>  U2194 PCT

<150>  EP 12185425.1
<151>  2012-09-21

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: sequence alignment"

<220>
<221>  variant
<222>  12  
<223> /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221>  variant
<222>  13  
<223> /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221>  variant
<222>  14  
<223> /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221>  variant
<222>  15  
<223> /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221>  variant
<222>  16  
<223> /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"

<220>
<221>  variant
<222>  17  
<223> /replace="Cys"
      /replace="Asp"
      /replace="Glu"
      /replace="Phe"
      /replace="Gly"
      /replace="His"
      /replace="Ile"
      /replace="Lys"
      /replace="Leu"
      /replace="Met"
      /replace="Asn"
      /replace="Pro"
      /replace="Gln"
      /replace="Arg"
      /replace="Ser"
      /replace="Thr"
      /replace="Val"
      /replace="Trp"
      /replace="Tyr"


<400>  1

Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Ser Thr 
            20                  25                  30          


His Glu Tyr Glu Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              


Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  


<210>  2
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: recombinant src-loop"

<400>  2

Ser Thr His Glu Tyr Glu 
1               5       


<210>  3
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 1L3-B9"

<400>  3

Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Ala Asn His Gly Asn 
1               5                   10                  15      


Arg Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Ser Thr 
            20                  25                  30          


His Glu Tyr Glu Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              


Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  


<210>  4
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 11L0-C6"

<400>  4

Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Lys Gln Lys Gly His 
1               5                   10                  15      


Leu Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Ser Thr 
            20                  25                  30          


His Glu Tyr Glu Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              


Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  


<210>  5
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 11L5-B06"

<400>  5

Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Ser Ala Arg Gly Gln 
1               5                   10                  15      


Leu Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Ser Thr 
            20                  25                  30          


His Glu Tyr Glu Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              


Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  


<210>  6
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 11L6-F03"

<400>  6

Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Asp Lys Leu Ser Ala 
1               5                   10                  15      


Leu Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Ser Thr 
            20                  25                  30          


His Glu Tyr Glu Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              


Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  


<210>  7
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 11L9-C09"

<400>  7

Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ser Val Ser Trp 
1               5                   10                  15      


Ser Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Ser Thr 
            20                  25                  30          


His Glu Tyr Glu Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              


Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  


<210>  8
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 11L10-A05"

<400>  8

Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Ser Ser Arg Gly Val 
1               5                   10                  15      


Leu Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Ser Thr 
            20                  25                  30          


His Glu Tyr Glu Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              


Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  


<210>  9
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: 11L11-A09"

<400>  9

Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Ser Arg Lys Ser Asn 
1               5                   10                  15      


Leu Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Ser Thr 
            20                  25                  30          


His Glu Tyr Glu Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              


Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  


<210>  10
<211>  155
<212>  PRT
<213>  Homo sapiens

<220>
<223>  human IL-17A, including signal sequence

<400>  10

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  11
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: light chain anti-TNF 
       antibody"

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  12
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: heavy chain anti-TNF 
       antibody"

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  13
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: linker"

<400>  13

Gly Gly Gly Gly Ser 
1               5   


<210>  14
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: linker"

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: linker"

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  16
<211>  293
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: light chain anti-TNF 
       antibody/linker/11L5-B06"

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr 
225                 230                 235                 240 


Ser Ala Arg Gly Gln Leu Asp Leu Ser Phe His Lys Gly Glu Lys Phe 
                245                 250                 255     


Gln Ile Leu Ser Thr His Glu Tyr Glu Asp Trp Trp Glu Ala Arg Ser 
            260                 265                 270         


Leu Thr Thr Gly Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro 
        275                 280                 285             


Val Asp Ser Ile Gln 
    290             


<210>  17
<211>  293
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: light chain anti-TNF 
       antibody/linker/11L9-C09"

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr 
225                 230                 235                 240 


Glu Ser Val Ser Trp Ser Asp Leu Ser Phe His Lys Gly Glu Lys Phe 
                245                 250                 255     


Gln Ile Leu Ser Thr His Glu Tyr Glu Asp Trp Trp Glu Ala Arg Ser 
            260                 265                 270         


Leu Thr Thr Gly Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro 
        275                 280                 285             


Val Asp Ser Ile Gln 
    290             


<210>  18
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: recombinant sequence"

<400>  18

Ser Thr His Glu Tyr Glu Asp 
1               5           


<210>  19
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of artificial sequence: recombinant RT-loop"

<400>  19

Glu Ala Arg Thr Glu Asp 
1               5       


<210>  20
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Glu 
1               5                   10                  15      


Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Asn Ser 
            20                  25                  30          


Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu Thr 
        35                  40                  45              


Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60              


