                         SEQUENCE LISTING

<110>  INNATE PHARMA
 
<120>  KIR3DL2 BINDING AGENTS

<130>  KIR-2

<150>  US 61/702,823
<151>  2012-09-19

<160>  181   

<170>  PatentIn version 3.5

<210>  1
<211>  434
<212>  PRT
<213>  homo sapiens

<400>  1

Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Arg Pro Ser Thr 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Ala Leu Gln Cys His Tyr Arg Arg 
            20                  25                  30          


Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ser His Val Pro 
        35                  40                  45              


Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe Ile Met Gly Pro Val 
    50                  55                  60                  


Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg Gly Ser Arg Pro His 
65                  70                  75                  80  


Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro Leu Val Ile Met Val 
                85                  90                  95      


Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu 
            100                 105                 110         


Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val Met 
        115                 120                 125             


Phe Glu His Phe Phe Leu His Arg Glu Gly Ile Ser Glu Asp Pro Ser 
    130                 135                 140                 


Arg Leu Val Gly Gln Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser 
145                 150                 155                 160 


Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu 
            180                 185                 190         


Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala Gln 
        195                 200                 205             


Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val Thr Leu Ser Cys Ser 
    210                 215                 220                 


Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser Arg Glu Gly Glu Ala 
225                 230                 235                 240 


His Glu Arg Arg Leu Arg Ala Val Pro Lys Val Asn Arg Thr Phe Gln 
                245                 250                 255     


Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg Cys 
            260                 265                 270         


Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp Ser Asn Ser Ser Asp 
        275                 280                 285             


Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser 
    290                 295                 300                 


Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys Arg His Leu His Val 
305                 310                 315                 320 


Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe Ile Leu Leu Leu Phe 
                325                 330                 335     


Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met 
            340                 345                 350         


Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn Arg Gln Asp Ser Asp 
        355                 360                 365             


Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Val 
    370                 375                 380                 


Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln Arg Pro Lys Thr Pro 
385                 390                 395                 400 


Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro Asn Ala Glu Pro Arg 
                405                 410                 415     


Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln Ser Gly Leu Glu Gly 
            420                 425                 430         


Val Phe 
        


<210>  2
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  2

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Arg Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Gly Tyr Tyr Pro Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  3
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Phe Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  4
<211>  5
<212>  PRT
<213>  mus musculus

<400>  4

Asp Ala Trp Met Asp 
1               5   


<210>  5
<211>  6
<212>  PRT
<213>  mus musculus

<400>  5

Gly Phe Thr Phe Ser Asp 
1               5       


<210>  6
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Phe Thr Phe Ser Asp Ala Trp Met Asp 
1               5                   10  


<210>  7
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  7

Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser Val 
1               5                   10                  15      


<210>  8
<211>  9
<212>  PRT
<213>  mus musculus

<400>  8

Ile Arg Ser Lys Ala Asn Asn His Ala 
1               5                   


<210>  9
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  9

Gly Tyr Tyr Pro Val Tyr 
1               5       


<210>  10
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  10

Lys Ala Ser Gln Asp Ile Asn Lys Asn Ile Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  11

Tyr Thr Ser Thr Leu Gln Pro 
1               5           


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

Leu Gln Tyr Asp Asn Leu Leu Thr 
1               5               


<210>  13
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  13

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Gly Asn Phe Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  14
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  14

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Phe Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Ser Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Thr Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  15

Asn Phe Gly Met Asn 
1               5   


<210>  16
<211>  6
<212>  PRT
<213>  mus musculus

<400>  16

Gly Tyr Thr Phe Thr Asn 
1               5       


<210>  17
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  17

Gly Tyr Thr Phe Thr Asn Phe Gly Met Asn 
1               5                   10  


<210>  18
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  18

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
1               5                   10                  15  


<210>  19
<211>  8
<212>  PRT
<213>  mus musculus

<400>  19

Trp Ile Asn Thr Tyr Thr Gly Glu 
1               5               


<210>  20
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  20

Asn Gly Asn Phe Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  21
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  21

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  22
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  22

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  23

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  24
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ser Arg Ser Phe Gly Ser Thr Tyr Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  25
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  25

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  26
<211>  5
<212>  PRT
<213>  mus musculus

<400>  26

Asn Tyr Gly Met Asn 
1               5   


<210>  27
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  27

Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  28
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  28

Ser Phe Gly Ser Thr Tyr Gly Asp Tyr 
1               5                   


<210>  29
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  29

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  30
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  30

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  31

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  32
<211>  157
<212>  PRT
<213>  mus musculus

<400>  32

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Asn Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala His Gly Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Thr Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asn Arg Ile Pro Ala Ala Ala Met Ala Ala Gly Ala 
145                 150                 155         


<210>  33
<211>  107
<212>  PRT
<213>  mus musculus

<400>  33

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Leu Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Cys 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Thr Leu Glu Ile Lys 
            100                 105         


<210>  34
<211>  6
<212>  PRT
<213>  mus musculus

<400>  34

Gly Tyr Ile Phe Thr Asn 
1               5       


<210>  35
<211>  10
<212>  PRT
<213>  mus musculus

<400>  35

Gly Tyr Ile Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  36
<211>  17
<212>  PRT
<213>  mus musculus

<400>  36

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  10
<212>  PRT
<213>  mus musculus

<400>  37

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
1               5                   10  


<210>  38
<211>  6
<212>  PRT
<213>  mus musculus

<400>  38

Gly Pro Trp Leu Ala Tyr 
1               5       


<210>  39
<211>  11
<212>  PRT
<213>  mus musculus

<400>  39

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  40
<211>  7
<212>  PRT
<213>  mus musculus

<400>  40

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  41
<211>  9
<212>  PRT
<213>  mus musculus

<400>  41

Leu Gln Tyr Asp Glu Leu Pro Tyr Thr 
1               5                   


<210>  42
<211>  112
<212>  PRT
<213>  mus musculus

<400>  42

Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met 
            20                  25                  30          


Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp 
        35                  40                  45              


Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly 
    50                  55                  60                  


Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln 
65                  70                  75                  80  


Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala His 
                85                  90                  95      


Gly Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


<210>  43
<211>  107
<212>  PRT
<213>  mus musculus

<400>  43

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Val Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ile Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Asp Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu 
            100                 105         


<210>  44
<211>  11
<212>  PRT
<213>  mus musculus

<400>  44

Lys Ala Ser Gln Asp Ile Asn Val Tyr Leu Ser 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  mus musculus

<400>  45

Arg Ala Ile Arg Leu Val Asp 
1               5           


<210>  46
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  46

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser His Tyr Ser Phe Ile Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Arg His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ser Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Trp Gly Tyr Pro Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser 
        115                 


<210>  47
<211>  111
<212>  PRT
<213>  mus musculus

<400>  47

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Phe 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  48
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  48

Gly Tyr Thr Met Asn 
1               5   


<210>  49
<211>  6
<212>  PRT
<213>  mus musculus

<400>  49

His Tyr Ser Phe Ile Gly 
1               5       


<210>  50
<211>  10
<212>  PRT
<213>  mus musculus

<400>  50

His Tyr Ser Phe Ile Gly Tyr Thr Met Asn 
1               5                   10  


<210>  51
<211>  17
<212>  PRT
<213>  mus musculus

<400>  51

Leu Ile Asn Pro Tyr Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  10
<212>  PRT
<213>  mus musculus

<400>  52

Leu Ile Asn Pro Tyr Asn Gly Asp Thr Thr 
1               5                   10  


<210>  53
<211>  11
<212>  PRT
<213>  mus musculus

<400>  53

Glu Asn Trp Gly Tyr Pro Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  54
<211>  15
<212>  PRT
<213>  mus musculus

<400>  54

Arg Ala Ser Glu Ser Val Asp Asn Phe Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  55
<211>  7
<212>  PRT
<213>  mus musculus

<400>  55

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  mus musculus

<400>  56

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  57
<211>  117
<212>  PRT
<213>  homo sapiens

<400>  57

Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Arg Pro Ser 
1               5                   10                  15      


Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln Cys His Tyr Arg 
            20                  25                  30          


Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ser His Val 
        35                  40                  45              


Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe Ile Met Gly Pro 
    50                  55                  60                  


Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg Gly Ser Arg Pro 
65                  70                  75                  80  


His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro Leu Val Ile Met 
                85                  90                  95      


Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro 
            100                 105                 110         


Leu Leu Lys Ser Gly 
        115         


<210>  58
<211>  100
<212>  PRT
<213>  homo sapiens

<400>  58

Thr Val Ile Leu Gln Cys Trp Ser Asp Val Met Phe Glu His Phe Phe 
1               5                   10                  15      


Leu His Arg Glu Gly Ile Ser Glu Asp Pro Ser Arg Leu Val Gly Gln 
            20                  25                  30          


Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser Ile Gly Pro Leu Met 
        35                  40                  45              


Pro Val Leu Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser 
    50                  55                  60                  


Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr 
65                  70                  75                  80  


Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val 
                85                  90                  95      


Gln Ala Gly Glu 
            100 


<210>  59
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  59

Asn Val Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His 
1               5                   10                  15      


Leu Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro 
            20                  25                  30          


Lys Val Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr 
        35                  40                  45              


His Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys 
    50                  55                  60                  


Val Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn 
65                  70                  75                  80  


Pro Ser Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly 
                85                  90                  95      


Ile Cys Arg His Leu His 
            100         


<210>  60
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  60
aagctagcgg taagcctatc cctaaccctc tcctcggtct cgattctacg ctcatgggtg       60

gtcaggacaa ac                                                           72


<210>  61
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  61
aaggatccct ctcctgattt cagcagggt                                         29


<210>  62
<211>  71
<212>  DNA
<213>  Homo sapiens

<400>  62
aagctagcgg taagcctatc cctaaccctc tcctcggtct cgattctacg acagtcatcc       60

tgcaatgttg g                                                            71


<210>  63
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  63
aaggatccct ctcctgcctg aaccgtggg                                         29


<210>  64
<211>  71
<212>  DNA
<213>  Homo sapiens

<400>  64
aagctagcgg taagcctatc cctaaccctc tcctcggtct cgattctacg aacgtgacct       60

tgtcctgtag c                                                            71


<210>  65
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  65
aaggatccat gcaggtgtct gcagatacc                                         29


<210>  66
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  66
actaatgcca ccaccaaggc ggctggtggt gccctgcagt caacagccag tctcttcgtg       60

gtctcactct ctcttctgca tctctactct                                        90


<210>  67
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  67

Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser Thr Ala 
1               5                   10                  15      


Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
            20                  25                  30  


<210>  68
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  68
acccaagctg gctagcatgt cgctcacggt cgtcagcatg                             40


<210>  69
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  69
agcacagtgg cggccgccta gaaaaccccc tcaagacc                               38


<210>  70
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  70
gccacaggtg catatgagaa accttctctc tcagcc                                 36


<210>  71
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  71
tgggtcactt gcggctgacc acacgcaggg caggg                                  35


<210>  72
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  72
cgtgccctgc cctacgtgtg gtcaaactca agtgac                                 36


<210>  73
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  73
atgcaggtgt ctggggatac cagatttgga gcttggttc                              39


<210>  74
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  74
ccgaagagtc acgtgtcctc ctcgaggcac cacagtgctg ggccaggcag a                51


<210>  75
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  75
cacgtgactc ttcggtgtca ctatcgtcgt ggg                                    33


<210>  76
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  76
cacagggctc atgttgaagc tctcctggaa tattc                                  35


<210>  77
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  77
aacatgagcc ctgtgacccc agcacatg                                          28


<210>  78
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  78
attgttaaac ctatgacgat agtgacactg aagag                                  35


<210>  79
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  79
cataggttta acaatttcat gctgtac                                           27


<210>  80
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  80
gatgggaatg tggattctgt cttctttgta cagcatg                                37


<210>  81
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  81
atccacattc ccatcttcca cggcagaata ttc                                    33


<210>  82
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  82
atgtgctgtg gtcacagggc ccatgatgaa g                                      31


<210>  83
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  83
gtgaccacag cacatgcagg gacctacag                                         29


<210>  84
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  84
gggggagtgt gggtgtgaac cccgacatct gtag                                   34


<210>  85
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  85
cacccacact cccccactgg gtggtcggca c                                      31


<210>  86
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  86
ttgcaggatg actctctctc ctgatttcac cagggg                                 36


<210>  87
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  87
agagtcatcc tgcaatgttg gtcagatgtc                                        30


<210>  88
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  88
ctcaaacatg atatctgacc aacattgcag gatgac                                 36


<210>  89
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  89
gatatcatgt ttgagcactt ctttctgcac                                        30


<210>  90
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  90
aagggcaagc atcatgggac cgatggagaa gttggccttg                             40


<210>  91
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  91
atgatgcttg cccttgcagg aacctacaga tgttatgg                               38


<210>  92
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  92
tagagatccc atctttgtgc agaaagaagt gctcaaacat                             40


<210>  93
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  93
aagatgggat ctctaaggac ccctcacgcc tcgttgg                                37


<210>  94
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  94
gggggtgtga gtaacagaac cataacatct gtagg                                  35


<210>  95
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  95
gttactcaca ccccctatca gttgtcagct c                                      31


<210>  96
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  96
atatgcacct gtggccacga tgtccagggg gtcactgg                               38


<210>  97
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  97
gccgcaagtg acccactgct tgtttctgtc                                        30


<210>  98
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  98
ggcctctcct gcctgaaccg cggggcccgg ctgggctgag                             40


<210>  99
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  99
caggcaggag aggccgtgac cttgtcctgt agctcc                                 36


<210>  100
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  100
ataggagctc gcggagctac aggacaaggt cac                                    33


<210>  101
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  101
tccgcgagct cctatgacat ctaccatctg tcc                                    33


<210>  102
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  102
atgggcctcc ccttccctgg acagatggta catgtcatag ga                          42


<210>  103
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  103
gaaggggagg cccatgaacg taggctccct gcagtg                                 36


<210>  104
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  104
atgtgctcca ccttccctgg acagatggta gatgtc                                 36


<210>  105
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  105
gaaggtggag cacatgaacg taggctccgt gcagtg                                 36


<210>  106
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  106
tctgttgacc ttggccactg cacggagcct acgttc                                 36


<210>  107
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  107
gccaaggtca acagaacatt ccaggcagac                                        30


<210>  108
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  108
cgcggcgggc gcgtgacgga aagagccgaa gcatctg                                37


<210>  109
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  109
cacgcgcccg ccgcgtggtc aaactcaagt gaccc                                  35


<210>  110
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  110
ctcgcagggc gagtgacgga aagagccgaa gcatctgtag                             40


<210>  111
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  111
cactcgccct gcgagtggtc aaactcaagt gaccc                                  35


<210>  112
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  112
gtagggcagg gcacggaaag agccgaagca                                        30


<210>  113
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  113
cccagacacc tgcatgttct gattg                                             25


<210>  114
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ala Asn Asn His Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Gly Tyr Tyr Pro Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  115
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  115
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gacgcctgga tggactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt attagaagca aagctaacaa tcacgccaca      180

gcatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc aaagaactca      240

ctgtatctgc aaatgaacag cctgaaaacc gaggacacgg ccgtgtatta ctgtaccggt      300

ggttactacc ctgtttactg gggccaaggg actctggtca ctgtctcttc a               351


<210>  116
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Gly Tyr Tyr Pro Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  117
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  117
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gacgcctgga tggactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggcgag attagaagca aagctaacaa tcacgccaca      180

tactacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc aaagaactca      240

ctgtatctgc aaatgaacag cctgaaaacc gaggacacgg ccgtgtatta ctgtaccggt      300

ggttactacc ctgtttactg gggccaaggg actctggtca ctgtctcttc a               351


<210>  118
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Gly Tyr Tyr Pro Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  119
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  119
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gacgcctgga tggactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttgccgag attagaagca aagctaacaa tcacgccaca      180

tactacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc aaagaactca      240

gtgtatctgc aaatgaacag cctgaaaacc gaggacacgg ccgtgtatta ctgtaccggt      300

ggttactacc ctgtttactg gggccaaggg actctggtca ctgtctcttc a               351


<210>  120
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  120

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Gln Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  121
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  121
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggcgagtca ggacattaac aagaatatag cttggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctactat acatccactt tgcaaccagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtctacag tatgataatc tccttacgtt cggagggggg      300

accaaggtgg aaataaaa                                                    318


<210>  122
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  123
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  123
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggcgagtca ggacattaac aagaatatag cttggtatca gcataaacca      120

gggaaagccc ctaagctcct gatccactat acatccactt tgcaaccagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtctacag tatgataatc tccttacgtt cggagggggg      300

accaaggtgg aaataaaa                                                    318


<210>  124
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  125
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric human-mouse

<400>  125
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggcgagtca ggacattaac aagaatatag cttggtatca gcataaacca      120

gggaaagccc ctaagctcct gatccactat acatccactt tgcaaccagg ggtcccatca      180

aggttcagtg gaagtggatc tgggagagat tatactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtctacag tatgataatc tccttacgtt cggagggggg      300

accaaggtgg aaataaaa                                                    318


<210>  126
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  126

Arg Ser Ser Gln Xaa Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  127
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (7)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (13)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  127

Xaa Xaa Ser Gln Xaa Ile Xaa Xaa Xaa Asn Xaa Asn Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210>  128
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  128

Xaa Xaa Thr Ser Thr Leu Gln Xaa 
1               5               


<210>  129
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (3)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  129

Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Thr 
1               5                   


<210>  130
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  130

Phe Gln Gly Ser His Val Pro Xaa Thr 
1               5                   


<210>  131
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  131

Gly Tyr Thr Phe Thr Asn Xaa Gly Met Asn 
1               5                   10  


<210>  132
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (5)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  132

Gly Xaa Thr Phe Xaa Xaa Xaa Xaa Met Xaa 
1               5                   10  


<210>  133
<211>  15
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (6)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (13)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  133

Asn Xaa Xaa Thr Tyr Xaa Xaa Xaa Xaa Xaa Tyr Ala Xaa Xaa Xaa 
1               5                   10                  15  


<210>  134
<211>  21
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (1)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (8)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (12)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  134

Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa Xaa Thr Tyr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Tyr Ala Xaa Xaa Xaa 
            20      


<210>  135
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (1)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  135

Xaa Xaa Xaa Xaa Gly Xaa Xaa Tyr Xaa Asp Tyr 
1               5                   10      


<210>  136
<211>  41
<212>  DNA
<213>  HOMO SAPIENS

<400>  136
tgtggtcaca gggcccatga tgaagctctc ctggaatatt c                           41


<210>  137
<211>  36
<212>  DNA
<213>  HOMO SAPIENS

<400>  137
ggccctgtga ccacagcaca tgcagggacc tacaga                                 36


<210>  138
<211>  39
<212>  DNA
<213>  HOMO SAPIENS

<400>  138
gtcactggga gctgacaact gatagggggt gtgagtaac                              39


<210>  139
<211>  38
<212>  DNA
<213>  HOMO SAPIENS

<400>  139
tcagctccca gtgaccccct ggacatcgtg atcacagg                               38


<210>  140
<211>  36
<212>  DNA
<213>  HOMO SAPIENS

<400>  140
gatatctgac caacattgca ggatgactgt ctctcc                                 36


<210>  141
<211>  36
<212>  DNA
<213>  HOMO SAPIENS

<400>  141
tgttggtcag atatcatgtt tgagcacttc tttctg                                 36


<210>  142
<211>  36
<212>  DNA
<213>  HOMO SAPIENS

<400>  142
ggaggaagga gcagaaccat aacatctgta ggttcc                                 36


<210>  143
<211>  36
<212>  DNA
<213>  HOMO SAPIENS

<400>  143
tctgctcctt cctcccccta tcagttgtca gctccc                                 36


<210>  144
<211>  33
<212>  DNA
<213>  HOMO SAPIENS

<400>  144
gatcaccagg gggttgctgg gagccgacca ccc                                    33


<210>  145
<211>  45
<212>  DNA
<213>  HOMO SAPIENS

<400>  145
aaccccctgg tgatcatggt cacaggaagc tccagaaaac cttcc                       45


<210>  146
<211>  45
<212>  DNA
<213>  HOMO SAPIENS

<400>  146
gtccaggggg tcactcccag ctgacaacgc atagggggag tgagg                       45


<210>  147
<211>  31
<212>  DNA
<213>  HOMO SAPIENS

<400>  147
agtgaccccc tggacatcgt gatcacaggt c                                      31


<210>  148
<211>  37
<212>  DNA
<213>  HOMO SAPIENS

<400>  148
agagatccca tctctgtgca gaaagaagga cgaaaac                                37


<210>  149
<211>  33
<212>  DNA
<213>  HOMP SAPIENS

<400>  149
agagatggga tctctgagga cccctcaagc ctc                                    33


<210>  150
<211>  33
<212>  DNA
<213>  HOMO SAPIENS

<400>  150
atggatcgat ccagcgaggc gtgaggggtc ctc                                    33


<210>  151
<211>  33
<212>  DNA
<213>  HOMO SAPIENS

<400>  151
gctggatcga tccatgatgg ggtctccaag gcc                                    33


<210>  152
<211>  45
<212>  DNA
<213>  HOMO SAPIENS

<400>  152
ctcagagatc ccatctctgt gcagaaagaa gtgctcaaac gcgac                       45


<210>  153
<211>  46
<212>  DNA
<213>  HOMO SAPIENS

<400>  153
gatgggatct ctgaggaccc ctcacgcctc gttggacagg cccatg                      46


<210>  154
<211>  35
<212>  DNA
<213>  HOMO SAPIENS

<400>  154
tcctcctcga ggcaccacag tgctgggcca ggcag                                  35


<210>  155
<211>  41
<212>  DNA
<213>  HOMO SAPIENS

<400>  155
gtgcctcgag gaggacacgt gactcttcgg tgtcactatc g                           41


<210>  156
<211>  34
<212>  DNA
<213>  HOMO SAPIENS

<400>  156
tggggtcaca gggctcatgt tgaagctctc ctgg                                   34


<210>  157
<211>  41
<212>  DNA
<213>  HOMO SAPIENS

<400>  157
agccctgtga ccccagcaca tgcagggacc tacagatgtc g                           41


<210>  158
<211>  33
<212>  DNA
<213>  HOMO SAPIENS

<400>  158
ggcagccagg gagggtttgt cctgaccacc cat                                    33


<210>  159
<211>  35
<212>  DNA
<213>  HOMO SAPIENS

<400>  159
ccctccctgg ctgcccggcc cagcactgtg gtgcc                                  35


<210>  160
<211>  36
<212>  DNA
<213>  HOMO SAPIENS

<400>  160
cccacgacga taggaacact gaagagccac gtgtcc                                 36


<210>  161
<211>  36
<212>  DNA
<213>  HOMO SAPIENS

<400>  161
tcctatcgtc gtggggctaa caatttcatg ctgtac                                 36


<210>  162
<211>  34
<212>  DNA
<213>  HOMO SAPIENS

<400>  162
tatgctgccg tgggcgatgg gaacgtggct tctg                                   34


<210>  163
<211>  33
<212>  DNA
<213>  HOMO SAPIENS

<400>  163
gcccacggca gcatattcca ggagagcttc atc                                    33


<210>  164
<211>  35
<212>  DNA
<213>  HOMO SAPIENS

<400>  164
gaagctcgcc gagaatattc tgccgtggaa gatgg                                  35


<210>  165
<211>  33
<212>  DNA
<213>  HOMO SAPIENS

<400>  165
ttctcggcga gcttcatcat gggccctgtg acc                                    33


<210>  166
<211>  36
<212>  DNA
<213>  HOMO SAPIENS

<400>  166
tcctcgaggc accacagtgg cggaccgggc agacag                                 36


<210>  167
<211>  37
<212>  DNA
<213>  HOMO SAPIENS

<400>  167
gtggtgcctc gaggaggatc cgtggctctt cagtgtc                                37


<210>  168
<211>  31
<212>  DNA
<213>  HOMO SAPIENS

<400>  168
gtcctcttgg atcccatctc tgtgcagaaa g                                      31


<210>  169
<211>  32
<212>  DNA
<213>  HOMO SAPIENS

<400>  169
gggatccaag aggacccctc acgcctcgtt gg                                     32


<210>  170
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Asp Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  171
<211>  455
<212>  PRT
<213>  HOMO SAPIENS

<400>  171

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  172
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  173
<211>  455
<212>  PRT
<213>  HOMO SAPIENS

<400>  173

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Ala Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser His Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Pro Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Thr Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  174
<211>  455
<212>  PRT
<213>  HOMO SAPIENS

<400>  174

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser His Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  175
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  175

Lys Pro Phe Leu Ser Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly 
1               5                   10                  15      


His Val Ala Leu Gln Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met 
            20                  25                  30          


Leu Tyr Lys Glu Asp Arg Ser His Val Pro Ile Phe His Gly Arg Ile 
        35                  40                  45              


Phe Gln Glu Ser Phe Ile Met Gly Pro Val Thr Pro Ala His Ala Gly 
    50                  55                  60                  


Thr Tyr Arg Cys Arg Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser 
65                  70                  75                  80  


Thr Pro Ser Asn Pro Leu Val Ile Met Val Thr Gly Asn His Arg Lys 
                85                  90                  95      


Pro Ser Leu Leu Ala His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr 
            100                 105                 110         


Val Ile Leu Gln Cys Trp Ser Asp Val Met Phe Glu His Phe Phe Leu 
        115                 120                 125             


His Arg Glu Gly Ile Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile 
    130                 135                 140                 


His Asp Gly Val Ser Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro 
145                 150                 155                 160 


Val Leu Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro 
                165                 170                 175     


Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly 
            180                 185                 190         


Leu Tyr Glu Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln 
        195                 200                 205             


Ala Gly Glu Asn Val Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp 
    210                 215                 220                 


Ile Tyr His Leu Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg 
225                 230                 235                 240 


Ala Val Pro Lys Val Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly 
                245                 250                 255     


Pro Ala Thr His Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala 
            260                 265                 270         


Leu Pro Cys Val Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val 
        275                 280                 285             


Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser 
    290                 295                 300                 


Lys Ser Gly Ile Cys Arg His Leu His Val Leu Ile Gly Thr Ser Val 
305                 310                 315                 320 


Val Ile Phe Leu Phe Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp 
                325                 330                 335     


Cys Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly 
            340                 345                 350         


Asp Arg Thr Val Asn Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu 
        355                 360                 365             


Val Thr Tyr Ala Gln Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile 
    370                 375                 380                 


Ser Arg Pro Ser Gln Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val 
385                 390                 395                 400 


Tyr Thr Glu Leu Pro Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys 
                405                 410                 415     


Pro Arg Ala Pro Gln Ser Gly Leu Glu Gly Val Phe 
            420                 425             


<210>  176
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  176

Lys Pro Phe Leu Ser Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly 
1               5                   10                  15      


His Val Ala Leu Gln Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met 
            20                  25                  30          


Leu Tyr Lys Glu Asp Arg Ser His Val Pro Ile Phe His Gly Arg Ile 
        35                  40                  45              


Phe Gln Glu Ser Phe Ile Met Gly Pro Val Thr Pro Ala His Ala Gly 
    50                  55                  60                  


Thr Tyr Arg Cys Arg Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser 
65                  70                  75                  80  


Thr Pro Ser Asn Pro Leu Val Ile Met Val Thr Gly Asn His Arg Lys 
                85                  90                  95      


Pro Ser Leu Leu Ala His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr 
            100                 105                 110         


Val Ile Leu Gln Cys Trp Ser Asp Val Met Phe Glu His Phe Phe Leu 
        115                 120                 125             


His Arg Glu Gly Ile Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile 
    130                 135                 140                 


His Asp Gly Val Ser Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro 
145                 150                 155                 160 


Val Leu Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro 
                165                 170                 175     


Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly 
            180                 185                 190         


Leu Tyr Glu Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln 
        195                 200                 205             


Ala Gly Glu Asn Val Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp 
    210                 215                 220                 


Ile Tyr His Leu Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg 
225                 230                 235                 240 


Ala Val Pro Lys Val Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly 
                245                 250                 255     


Pro Ala Thr His Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala 
            260                 265                 270         


Leu Pro Cys Val Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val 
        275                 280                 285             


Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser 
    290                 295                 300                 


Lys Ser Gly Ile Cys Arg His Leu His Val Leu Ile Gly Thr Ser Val 
305                 310                 315                 320 


Val Ile Phe Leu Phe Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp 
                325                 330                 335     


Cys Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly 
            340                 345                 350         


Asp Arg Thr Val Asn Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu 
        355                 360                 365             


Val Met Tyr Ala Gln Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile 
    370                 375                 380                 


Ser Arg Pro Ser Gln Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val 
385                 390                 395                 400 


Tyr Thr Glu Leu Pro Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys 
                405                 410                 415     


Pro Arg Ala Pro Gln Ser Gly Leu Glu Gly Val Phe 
            420                 425             


<210>  177
<211>  455
<212>  PRT
<213>  homo sapiens

<400>  177

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Gln Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Thr Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Pro Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  178
<211>  455
<212>  PRT
<213>  HOMO SAPIENS

<400>  178

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe His Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  179
<211>  455
<212>  PRT
<213>  HOMO SAPIENS

<400>  179

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Met Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  180
<211>  444
<212>  PRT
<213>  homo sapiens

<400>  180

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Leu Phe Leu Val 
1               5                   10                  15      


Gln Arg Ala Gly Pro His Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Trp Pro Ser Ala Val Val Pro Arg Gly Gly His Val Thr Leu Arg 
        35                  40                  45              


Cys His Tyr Arg His Arg Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ile His Ile Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Asn Met Ser Pro Val Thr Thr Ala His Ala Gly Asn Tyr Thr Cys Arg 
                85                  90                  95      


Gly Ser His Pro His Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Val Lys Ser Gly Glu Arg Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Ile Met Phe Glu His Phe Phe Leu His Lys Glu Gly Ile 
145                 150                 155                 160 


Ser Lys Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Met Met Leu Ala Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Thr His Thr Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Val Thr Gly Pro Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Lys Val Gln Ala Gly Glu Ser Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Gly Ala His Glu Arg Arg Leu Pro Ala Val Arg Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg His Ser Pro Tyr Glu Trp 
    290                 295                 300                 


Ser Asp Pro Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Asn Pro 
                325                 330                 335     


Arg His Leu His Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu His Leu Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Ala Asn 
    370                 375                 380                 


Ser Glu Asp Ser Asp Glu Gln Asp Pro Glu Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Pro Thr Asp Thr Ile Leu Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Lys Pro Arg Ser Lys Val Val Ser Cys Pro 
        435                 440                 


<210>  181
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  181

Xaa Phe Gly Xaa Xaa Tyr Xaa Asp Tyr 
1               5                   


