                         SEQUENCE LISTING

<110>  Madrigal Pharmaceuticals, Inc.
       F. Hoffmann-La Roche Ltd.     	
       
 
<120>  METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS 
       THEREOF

<130>  41245-522001WO

<150>  US 61/702,137
<151>  2012-09-17

<150>  US 61/790,432
<151>  2013-03-15

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Leu Gln Lys Ser Ile Gly His Lys Pro Glu Pro Thr Asp Glu Glu 
1               5                   10                  15      


Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala Thr Asn Ala 
            20                  25                  30          


Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro Glu Asp Ile 
        35                  40                  45              


Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys Val Asp Leu 
    50                  55                  60                  


Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala Ile Thr Arg 
65                  70                  75                  80  


Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu Leu Pro Cys 
                85                  90                  95      


Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu Ile Met Ser 
            100                 105                 110         


Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr Leu Thr Leu 
        115                 120                 125             


Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn Gly Gly Leu 
    130                 135                 140                 


Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Met Ser Leu Ser Ser 
145                 150                 155                 160 


Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala Val Leu Leu 
                165                 170                 175     


Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg Ile Glu Lys 
            180                 185                 190         


Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile Asn Tyr Arg 
        195                 200                 205             


Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met Lys Val Thr 
    210                 215                 220                 


Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe Leu His Met 
225                 230                 235                 240 


Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe Leu Glu Val 
                245                 250                 255     


Phe Glu Asp 
            


<210>  2
<211>  780
<212>  DNA
<213>  Homo sapiens

<400>  2
gagctgcaga agtccatcgg gcacaagcca gagcccacag acgaggaatg ggagctcatc       60

aaaactgtca ccgaagccca tgtggcgacc aacgcccaag gcagccactg gaagcaaaaa      120

cggaaattcc tgccagaaga cattggacaa gcaccaatag tcaatgcccc agaaggtgga      180

aaggttgact tggaagcctt cagccatttt acaaaaatca tcacaccagc aattaccaga      240

gtggtggatt ttgccaaaaa gttgcctatg ttttgtgagc tgccatgtga agaccagatc      300

atcctcctca aaggctgctg catggagatc atgtcccttc gcgctgctgt gcgctatgac      360

ccagaaagtg agactttaac cttgaatggg gaaatggcag tgacacgggg ccagctgaaa      420

aatgggggtc ttggggtggt gtcagacgcc atctttgacc tgggcatgtc tctgtcttct      480

ttcaacctgg atgacactga agtagccctc cttcaggccg tcctgctgat gtcttcagat      540

cgcccggggc ttgcctgtgt tgagagaata gaaaagtacc aagatagttt cctgctggcc      600

tttgaacact atatcaatta ccgaaaacac cacgtgacac acttttggcc aaaactcctg      660

atgaaggtga cagatctgcg gatgatagga gcctgccatg ccagccgctt cctgcacatg      720

aaggtggaat gccccacaga actcttcccc cctttgttct tggaagtgtt cgaggattag      780


