                               SEQUENCE LISTING

<110> BERG LLC
 
<120> USE OF MARKERS IN THE IDENTIFICATION OF CARDIOTOXIC AGENTS AND IN
      THE DIAGNOSIS AND MONITORING OF CARDIOMYOPATHY AND CARDIOVASCULAR 
      DISEASE

<130> 119992-07820

<140> NEW APPLICATION
<141> CONCURRENTLY HEREWITH

<150> 61/732,105
<151> 2012-11-30

<150> 61/727,115
<151> 2012-11-16

<150> 61/727,104
<151> 2012-11-15

<150> 61/706,611
<151> 2012-09-27

<150> 61/700,327
<151> 2012-09-12

<160> 461    

<170> PatentIn version 3.5

<210> 1
<211> 385
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 
    130                 135                 140                 


Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210> 2
<211> 2107
<212> DNA
<213> Homo sapiens

<400> 2
gtacatgcga gcgtgtgcgc gcgtgcgcag gcggggcgac cggcgtcccc ggcgctcgcc       60

ccgcccccga gatgacgccg tgcgtgcgcg cgcccggtcc gcgcctccgc cgctttttat      120

agcggccgcg ggcggcggcg gcagcggttg gaggttgtag gaccggcgag gaataggaat      180

catggcggct gcgctgttcg tgctgctggg attcgcgctg ctgggcaccc acggagcctc      240

cggggctgcc ggcttcgtcc aggcgccgct gtcccagcag aggtgggtgg ggggcagtgt      300

ggagctgcac tgcgaggccg tgggcagccc ggtgcccgag atccagtggt ggtttgaagg      360

gcagggtccc aacgacacct gctcccagct ctgggacggc gcccggctgg accgcgtcca      420

catccacgcc acctaccacc agcacgcggc cagcaccatc tccatcgaca cgctcgtgga      480

ggaggacacg ggcacttacg agtgccgggc cagcaacgac ccggatcgca accacctgac      540

ccgggcgccc agggtcaagt gggtccgcgc ccaggcagtc gtgctagtcc tggaacccgg      600

cacagtcttc actaccgtag aagaccttgg ctccaagata ctcctcacct gctccttgaa      660

tgacagcgcc acagaggtca cagggcaccg ctggctgaag gggggcgtgg tgctgaagga      720

ggacgcgctg cccggccaga aaacggagtt caaggtggac tccgacgacc agtggggaga      780

gtactcctgc gtcttcctcc ccgagcccat gggcacggcc aacatccagc tccacgggcc      840

tcccagagtg aaggctgtga agtcgtcaga acacatcaac gagggggaga cggccatgct      900

ggtctgcaag tcagagtccg tgccacctgt cactgactgg gcctggtaca agatcactga      960

ctctgaggac aaggccctca tgaacggctc cgagagcagg ttcttcgtga gttcctcgca     1020

gggccggtca gagctacaca ttgagaacct gaacatggag gccgaccccg gccagtaccg     1080

gtgcaacggc accagctcca agggctccga ccaggccatc atcacgctcc gcgtgcgcag     1140

ccacctggcc gccctctggc ccttcctggg catcgtggct gaggtgctgg tgctggtcac     1200

catcatcttc atctacgaga agcgccggaa gcccgaggac gtcctggatg atgacgacgc     1260

cggctctgca cccctgaaga gcagcgggca gcaccagaat gacaaaggca agaacgtccg     1320

ccagaggaac tcttcctgag gcaggtggcc cgaggacgct ccctgctcca cgtctgcgcc     1380

gccgccggag tccactccca gtgcttgcaa gattccaagt tctcacctct taaagaaaac     1440

ccaccccgta gattcccatc atacacttcc ttctttttta aaaaagttgg gttttctcca     1500

ttcaggattc tgttccttag gtttttttcc ttctgaagtg tttcacgaga gcccgggagc     1560

tgctgccctg cggccccgtc tgtggctttc agcctctggg tctgagtcat ggccgggtgg     1620

gcggcacagc cttctccact ggccggagtc agtgccaggt ccttgccctt tgtggaaagt     1680

cacaggtcac acgaggggcc ccgtgtcctg cctgtctgaa gccaatgctg tctggttgcg     1740

ccatttttgt gcttttatgt ttaattttat gagggccacg ggtctgtgtt cgactcagcc     1800

tcagggacga ctctgacctc ttggccacag aggactcact tgcccacacc gagggcgacc     1860

ccgtcacagc ctcaagtcac tcccaagccc cctccttgtc tgtgcatccg ggggcagctc     1920

tggagggggt ttgctgggga actggcgcca tcgccgggac tccagaaccg cagaagcctc     1980

cccagctcac ccctggagga cggccggctc tctatagcac cagggctcac gtgggaaccc     2040

ccctcccacc caccgccaca ataaagatcg cccccacctc caccctcaaa aaaaaaaaaa     2100

aaaaaaa                                                               2107


<210> 3
<211> 269
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr 
        35                  40                  45              


Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu 
    50                  55                  60                  


Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp 
65                  70                  75                  80  


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
                85                  90                  95      


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
            100                 105                 110         


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
        115                 120                 125             


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
    130                 135                 140                 


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
145                 150                 155                 160 


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
                165                 170                 175     


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
            180                 185                 190         


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
        195                 200                 205             


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
    210                 215                 220                 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
225                 230                 235                 240 


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
                245                 250                 255     


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
            260                 265                 


<210> 4
<211> 1759
<212> DNA
<213> Homo sapiens

<400> 4
gtacatgcga gcgtgtgcgc gcgtgcgcag gcggggcgac cggcgtcccc ggcgctcgcc       60

ccgcccccga gatgacgccg tgcgtgcgcg cgcccggtcc gcgcctccgc cgctttttat      120

agcggccgcg ggcggcggcg gcagcggttg gaggttgtag gaccggcgag gaataggaat      180

catggcggct gcgctgttcg tgctgctggg attcgcgctg ctgggcaccc acggagcctc      240

cggggctgcc ggcacagtct tcactaccgt agaagacctt ggctccaaga tactcctcac      300

ctgctccttg aatgacagcg ccacagaggt cacagggcac cgctggctga aggggggcgt      360

ggtgctgaag gaggacgcgc tgcccggcca gaaaacggag ttcaaggtgg actccgacga      420

ccagtgggga gagtactcct gcgtcttcct ccccgagccc atgggcacgg ccaacatcca      480

gctccacggg cctcccagag tgaaggctgt gaagtcgtca gaacacatca acgaggggga      540

gacggccatg ctggtctgca agtcagagtc cgtgccacct gtcactgact gggcctggta      600

caagatcact gactctgagg acaaggccct catgaacggc tccgagagca ggttcttcgt      660

gagttcctcg cagggccggt cagagctaca cattgagaac ctgaacatgg aggccgaccc      720

cggccagtac cggtgcaacg gcaccagctc caagggctcc gaccaggcca tcatcacgct      780

ccgcgtgcgc agccacctgg ccgccctctg gcccttcctg ggcatcgtgg ctgaggtgct      840

ggtgctggtc accatcatct tcatctacga gaagcgccgg aagcccgagg acgtcctgga      900

tgatgacgac gccggctctg cacccctgaa gagcagcggg cagcaccaga atgacaaagg      960

caagaacgtc cgccagagga actcttcctg aggcaggtgg cccgaggacg ctccctgctc     1020

cacgtctgcg ccgccgccgg agtccactcc cagtgcttgc aagattccaa gttctcacct     1080

cttaaagaaa acccaccccg tagattccca tcatacactt ccttcttttt taaaaaagtt     1140

gggttttctc cattcaggat tctgttcctt aggttttttt ccttctgaag tgtttcacga     1200

gagcccggga gctgctgccc tgcggccccg tctgtggctt tcagcctctg ggtctgagtc     1260

atggccgggt gggcggcaca gccttctcca ctggccggag tcagtgccag gtccttgccc     1320

tttgtggaaa gtcacaggtc acacgagggg ccccgtgtcc tgcctgtctg aagccaatgc     1380

tgtctggttg cgccattttt gtgcttttat gtttaatttt atgagggcca cgggtctgtg     1440

ttcgactcag cctcagggac gactctgacc tcttggccac agaggactca cttgcccaca     1500

ccgagggcga ccccgtcaca gcctcaagtc actcccaagc cccctccttg tctgtgcatc     1560

cgggggcagc tctggagggg gtttgctggg gaactggcgc catcgccggg actccagaac     1620

cgcagaagcc tccccagctc acccctggag gacggccggc tctctatagc accagggctc     1680

acgtgggaac ccccctccca cccaccgcca caataaagat cgcccccacc tccaccctca     1740

aaaaaaaaaa aaaaaaaaa                                                  1759


<210> 5
<211> 176
<212> PRT
<213> Homo sapiens

<400> 5
Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala 
1               5                   10                  15      


Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val 
            20                  25                  30          


Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys 
        35                  40                  45              


Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg 
    50                  55                  60                  


Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn 
65                  70                  75                  80  


Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser 
                85                  90                  95      


Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His 
            100                 105                 110         


Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val 
        115                 120                 125             


Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp 
    130                 135                 140                 


Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly 
145                 150                 155                 160 


Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
                165                 170                 175     


<210> 6
<211> 1814
<212> DNA
<213> Homo sapiens

<400> 6
cccgccagtg tagccacatt cctgcccctt tccagttagc ccttcgcgtt cggcttagtc       60

tgcggtcctc ttgcattgcg actccgagtt taacttccaa cacacacttt caacctccaa      120

gagacgcccc cacctgtgtc gccccaatag cgacttttct caccgtggtc gccgcggaac      180

ttcaagggtc cttcctaccc gcgttgctga gagtctgggt ttacgcgtca cctcgggcgg      240

gacccgatcc tccgctcctg aggcccccac aatgaagcag tcggacgcgt ctccccaaga      300

aagccggcac agtcttcact accgtagaag accttggctc caagatactc ctcacctgct      360

ccttgaatga cagcgccaca gaggtcacag ggcaccgctg gctgaagggg ggcgtggtgc      420

tgaaggagga cgcgctgccc ggccagaaaa cggagttcaa ggtggactcc gacgaccagt      480

ggggagagta ctcctgcgtc ttcctccccg agcccatggg cacggccaac atccagctcc      540

acgggcctcc cagagtgaag gctgtgaagt cgtcagaaca catcaacgag ggggagacgg      600

ccatgctggt ctgcaagtca gagtccgtgc cacctgtcac tgactgggcc tggtacaaga      660

tcactgactc tgaggacaag gccctcatga acggctccga gagcaggttc ttcgtgagtt      720

cctcgcaggg ccggtcagag ctacacattg agaacctgaa catggaggcc gaccccggcc      780

agtaccggtg caacggcacc agctccaagg gctccgacca ggccatcatc acgctccgcg      840

tgcgcagcca cctggccgcc ctctggccct tcctgggcat cgtggctgag gtgctggtgc      900

tggtcaccat catcttcatc tacgagaagc gccggaagcc cgaggacgtc ctggatgatg      960

acgacgccgg ctctgcaccc ctgaagagca gcgggcagca ccagaatgac aaaggcaaga     1020

acgtccgcca gaggaactct tcctgaggca ggtggcccga ggacgctccc tgctccacgt     1080

ctgcgccgcc gccggagtcc actcccagtg cttgcaagat tccaagttct cacctcttaa     1140

agaaaaccca ccccgtagat tcccatcata cacttccttc ttttttaaaa aagttgggtt     1200

ttctccattc aggattctgt tccttaggtt tttttccttc tgaagtgttt cacgagagcc     1260

cgggagctgc tgccctgcgg ccccgtctgt ggctttcagc ctctgggtct gagtcatggc     1320

cgggtgggcg gcacagcctt ctccactggc cggagtcagt gccaggtcct tgccctttgt     1380

ggaaagtcac aggtcacacg aggggccccg tgtcctgcct gtctgaagcc aatgctgtct     1440

ggttgcgcca tttttgtgct tttatgttta attttatgag ggccacgggt ctgtgttcga     1500

ctcagcctca gggacgactc tgacctcttg gccacagagg actcacttgc ccacaccgag     1560

ggcgaccccg tcacagcctc aagtcactcc caagccccct ccttgtctgt gcatccgggg     1620

gcagctctgg agggggtttg ctggggaact ggcgccatcg ccgggactcc agaaccgcag     1680

aagcctcccc agctcacccc tggaggacgg ccggctctct atagcaccag ggctcacgtg     1740

ggaacccccc tcccacccac cgccacaata aagatcgccc ccacctccac cctcaaaaaa     1800

aaaaaaaaaa aaaa                                                       1814


<210> 7
<211> 205
<212> PRT
<213> Homo sapiens

<400> 7
Met Lys Gln Ser Asp Ala Ser Pro Gln Glu Arg Val Asp Ser Asp Asp 
1               5                   10                  15      


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
            20                  25                  30          


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
        35                  40                  45              


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
    50                  55                  60                  


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
65                  70                  75                  80  


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
                85                  90                  95      


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
            100                 105                 110         


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
        115                 120                 125             


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
    130                 135                 140                 


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
145                 150                 155                 160 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
                165                 170                 175     


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
            180                 185                 190         


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
        195                 200                 205 


<210> 8
<211> 1657
<212> DNA
<213> Homo sapiens

<400> 8
cccgccagtg tagccacatt cctgcccctt tccagttagc ccttcgcgtt cggcttagtc       60

tgcggtcctc ttgcattgcg actccgagtt taacttccaa cacacacttt caacctccaa      120

gagacgcccc cacctgtgtc gccccaatag cgacttttct caccgtggtc gccgcggaac      180

ttcaagggtc cttcctaccc gcgttgctga gagtctgggt ttacgcgtca cctcgggcgg      240

gacccgatcc tccgctcctg aggcccccac aatgaagcag tcggacgcgt ctccccaaga      300

aagggtggac tccgacgacc agtggggaga gtactcctgc gtcttcctcc ccgagcccat      360

gggcacggcc aacatccagc tccacgggcc tcccagagtg aaggctgtga agtcgtcaga      420

acacatcaac gagggggaga cggccatgct ggtctgcaag tcagagtccg tgccacctgt      480

cactgactgg gcctggtaca agatcactga ctctgaggac aaggccctca tgaacggctc      540

cgagagcagg ttcttcgtga gttcctcgca gggccggtca gagctacaca ttgagaacct      600

gaacatggag gccgaccccg gccagtaccg gtgcaacggc accagctcca agggctccga      660

ccaggccatc atcacgctcc gcgtgcgcag ccacctggcc gccctctggc ccttcctggg      720

catcgtggct gaggtgctgg tgctggtcac catcatcttc atctacgaga agcgccggaa      780

gcccgaggac gtcctggatg atgacgacgc cggctctgca cccctgaaga gcagcgggca      840

gcaccagaat gacaaaggca agaacgtccg ccagaggaac tcttcctgag gcaggtggcc      900

cgaggacgct ccctgctcca cgtctgcgcc gccgccggag tccactccca gtgcttgcaa      960

gattccaagt tctcacctct taaagaaaac ccaccccgta gattcccatc atacacttcc     1020

ttctttttta aaaaagttgg gttttctcca ttcaggattc tgttccttag gtttttttcc     1080

ttctgaagtg tttcacgaga gcccgggagc tgctgccctg cggccccgtc tgtggctttc     1140

agcctctggg tctgagtcat ggccgggtgg gcggcacagc cttctccact ggccggagtc     1200

agtgccaggt ccttgccctt tgtggaaagt cacaggtcac acgaggggcc ccgtgtcctg     1260

cctgtctgaa gccaatgctg tctggttgcg ccatttttgt gcttttatgt ttaattttat     1320

gagggccacg ggtctgtgtt cgactcagcc tcagggacga ctctgacctc ttggccacag     1380

aggactcact tgcccacacc gagggcgacc ccgtcacagc ctcaagtcac tcccaagccc     1440

cctccttgtc tgtgcatccg ggggcagctc tggagggggt ttgctgggga actggcgcca     1500

tcgccgggac tccagaaccg cagaagcctc cccagctcac ccctggagga cggccggctc     1560

tctatagcac cagggctcac gtgggaaccc ccctcccacc caccgccaca ataaagatcg     1620

cccccacctc caccctcaaa aaaaaaaaaa aaaaaaa                              1657


<210> 9
<211> 288
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Arg Ser Gln Ala Pro Leu Leu Arg Trp Val Leu 
            260                 265                 270         


Thr Leu Ser Phe Leu Val Ala Thr Val Ala Val Gly Leu Tyr Ala Met 
        275                 280                 285             


<210> 10
<211> 1606
<212> DNA
<213> Homo sapiens

<400> 10
aaatgtgacc ggccgcggct ccggcagtca acgcctgcct cctctcgagc gtcctcagcg       60

cagccgccgc ccgcggagcc agcacgaacg agcccagcac cggccggatg gagcgtccgc      120

aacccgacag catgccccag gatttgtcag aggccctgaa ggaggccacc aaggaggtgc      180

acacccaggc agagaatgct gagttcatga ggaactttca gaagggccag gtgacccgag      240

acggcttcaa gctggtgatg gcctccctgt accacatcta tgtggccctg gaggaggaga      300

ttgagcgcaa caaggagagc ccagtcttcg cccctgtcta cttcccagaa gagctgcacc      360

gcaaggctgc cctggagcag gacctggcct tctggtacgg gccccgctgg caggaggtca      420

tcccctacac accagccatg cagcgctatg tgaagcggct ccacgaggtg gggcgcacag      480

agcccgagct gctggtggcc cacgcctaca cccgctacct gggtgacctg tctgggggcc      540

aggtgctcaa aaagattgcc cagaaagccc tggacctgcc cagctctggc gagggcctgg      600

ccttcttcac cttccccaac attgccagtg ccaccaagtt caagcagctc taccgctccc      660

gcatgaactc cctggagatg actcccgcag tcaggcagag ggtgatagaa gaggccaaga      720

ctgcgttcct gctcaacatc cagctctttg aggagttgca ggagctgctg acccatgaca      780

ccaaggacca gagcccctca cgggcaccag ggcttcgcca gcgggccagc aacaaagtgc      840

aagattctgc ccccgtggag actcccagag ggaagccccc actcaacacc cgctcccagg      900

ctccgcttct ccgatgggtc cttacactca gctttctggt ggcgacagtt gctgtagggc      960

tttatgccat gtgaatgcag gcatgctggc tcccagggcc atgaactttg tccggtggaa     1020

ggccttcttt ctagagaggg aattctcttg gctggcttcc ttaccgtggg cactgaaggc     1080

tttcagggcc tccagccctc tcactgtgtc cctctctctg gaaaggagga aggagcctat     1140

ggcatcttcc ccaacgaaaa gcacatccag gcaatggcct aaacttcaga gggggcgaag     1200

ggatcagccc tgcccttcag catcctcagt tcctgcagca gagcctggaa gacaccctaa     1260

tgtggcagct gtctcaaacc tccaaaagcc ctgagtttca agtatccttg ttgacacggc     1320

catgaccact ttccccgtgg gccatggcaa tttttacaca aacctgaaaa gatgttgtgt     1380

cttgtgtttt tgtcttattt ttgttggagc cactctgttc ctggctcagc ctcaaatgca     1440

gtatttttgt tgtgttctgt tgtttttata gcagggttgg ggtggttttt gagccatgcg     1500

tgggtgggga gggaggtgtt taacggcact gtggccttgg tctaactttt gtgtgaaata     1560

ataaacaaca ttgtctgata gtagcttgaa aaaaaaaaaa aaaaaa                    1606


<210> 11
<211> 282
<212> PRT
<213> Homo sapiens

<400> 11
Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Glu Gly Ala Glu Leu 
        275                 280         


<210> 12
<211> 1137
<212> DNA
<213> Homo sapiens

<400> 12
actcgcgccc ttgccgctgc caccgcaccc cgccatggag cggccgtcgc tgcgcgccct       60

gctcctcggc gccgctgggc tgctgctcct gctcctgccc ctctcctctt cctcctcttc      120

ggacacctgc ggcccctgcg agccggcctc ctgcccgccc ctgcccccgc tgggctgcct      180

gctgggcgag acccgcgacg cgtgcggctg ctgccctatg tgcgcccgcg gcgagggcga      240

gccgtgcggg ggtggcggcg ccggcagggg gtactgcgcg ccgggcatgg agtgcgtgaa      300

gagccgcaag aggcggaagg gtaaagccgg ggcagcagcc ggcggtccgg gtgtaagcgg      360

cgtgtgcgtg tgcaagagcc gctacccggt gtgcggcagc gacggcacca cctacccgag      420

cggctgccag ctgcgcgccg ccagccagag ggccgagagc cgcggggaga aggccatcac      480

ccaggtcagc aagggcacct gcgagcaagg tccttccata gtgacgcccc ccaaggacat      540

ctggaatgtc actggtgccc aggtgtactt gagctgtgag gtcatcggaa tcccgacacc      600

tgtcctcatc tggaacaagg taaaaagggg tcactatgga gttcaaagga cagaactcct      660

gcctggtgac cgggacaacc tggccattca gacccggggt ggcccagaaa agcatgaagt      720

aactggctgg gtgctggtat ctcctctaag taaggaagat gctggagaat atgagtgcca      780

tgcatccaat tcccaaggac aggcttcagc atcagcaaaa attacagtgg ttgatgcctt      840

acatgaaata ccagtgaaaa aaggtgaagg tgccgagcta taaacctcca gaatattatt      900

agtctgcatg gttaaaagta gtcatggata actacattac ctgttcttgc ctaataagtt      960

tcttttaatc caatccacta acactttagt tatattcact ggttttacac agagaaatac     1020

aaaataaaga tcacacatca agactatcta caaaaattta ttatatattt acagaagaaa     1080

agcatgcata tcattaaaca aataaaatac tttttatcac aacacagtaa aaaaaaa        1137


<210> 13
<211> 279
<212> PRT
<213> Homo sapiens

<400> 13
Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Thr Gln 
        275                 


<210> 14
<211> 1051
<212> DNA
<213> Homo sapiens

<400> 14
actcgcgccc ttgccgctgc caccgcaccc cgccatggag cggccgtcgc tgcgcgccct       60

gctcctcggc gccgctgggc tgctgctcct gctcctgccc ctctcctctt cctcctcttc      120

ggacacctgc ggcccctgcg agccggcctc ctgcccgccc ctgcccccgc tgggctgcct      180

gctgggcgag acccgcgacg cgtgcggctg ctgccctatg tgcgcccgcg gcgagggcga      240

gccgtgcggg ggtggcggcg ccggcagggg gtactgcgcg ccgggcatgg agtgcgtgaa      300

gagccgcaag aggcggaagg gtaaagccgg ggcagcagcc ggcggtccgg gtgtaagcgg      360

cgtgtgcgtg tgcaagagcc gctacccggt gtgcggcagc gacggcacca cctacccgag      420

cggctgccag ctgcgcgccg ccagccagag ggccgagagc cgcggggaga aggccatcac      480

ccaggtcagc aagggcacct gcgagcaagg tccttccata gtgacgcccc ccaaggacat      540

ctggaatgtc actggtgccc aggtgtactt gagctgtgag gtcatcggaa tcccgacacc      600

tgtcctcatc tggaacaagg taaaaagggg tcactatgga gttcaaagga cagaactcct      660

gcctggtgac cgggacaacc tggccattca gacccggggt ggcccagaaa agcatgaagt      720

aactggctgg gtgctggtat ctcctctaag taaggaagat gctggagaat atgagtgcca      780

tgcatccaat tcccaaggac aggcttcagc atcagcaaaa attacagtgg ttgatgcctt      840

acatgaaata ccagtgaaaa aaggtacaca ataaatctca cagccattta aaaatgacta      900

gtacatttgc tttaaaaaga acagaactaa gtatgaaagt atcagacgta gctattgatg      960

aaattctgta gttagcaacc cataagggca ttaagtatgc cattaaaatg tacagcatga     1020

gactccaaaa gattatctgg atgggtgact g                                    1051


<210> 15
<211> 483
<212> PRT
<213> Homo sapiens

<400> 15
Met Lys Ala Phe His Thr Phe Cys Val Val Leu Leu Val Phe Gly Ser 
1               5                   10                  15      


Val Ser Glu Ala Lys Phe Asp Asp Phe Glu Asp Glu Glu Asp Ile Val 
            20                  25                  30          


Glu Tyr Asp Asp Asn Asp Phe Ala Glu Phe Glu Asp Val Met Glu Asp 
        35                  40                  45              


Ser Val Thr Glu Ser Pro Gln Arg Val Ile Ile Thr Glu Asp Asp Glu 
    50                  55                  60                  


Asp Glu Thr Thr Val Glu Leu Glu Gly Gln Asp Glu Asn Gln Glu Gly 
65                  70                  75                  80  


Asp Phe Glu Asp Ala Asp Thr Gln Glu Gly Asp Thr Glu Ser Glu Pro 
                85                  90                  95      


Tyr Asp Asp Glu Glu Phe Glu Gly Tyr Glu Asp Lys Pro Asp Thr Ser 
            100                 105                 110         


Ser Ser Lys Asn Lys Asp Pro Ile Thr Ile Val Asp Val Pro Ala His 
        115                 120                 125             


Leu Gln Asn Ser Trp Glu Ser Tyr Tyr Leu Glu Ile Leu Met Val Thr 
    130                 135                 140                 


Gly Leu Leu Ala Tyr Ile Met Asn Tyr Ile Ile Gly Lys Asn Lys Asn 
145                 150                 155                 160 


Ser Arg Leu Ala Gln Ala Trp Phe Asn Thr His Arg Glu Leu Leu Glu 
                165                 170                 175     


Ser Asn Phe Thr Leu Val Gly Asp Asp Gly Thr Asn Lys Glu Ala Thr 
            180                 185                 190         


Ser Thr Gly Lys Leu Asn Gln Glu Asn Glu His Ile Tyr Asn Leu Trp 
        195                 200                 205             


Cys Ser Gly Arg Val Cys Cys Glu Gly Met Leu Ile Gln Leu Arg Phe 
    210                 215                 220                 


Leu Lys Arg Gln Asp Leu Leu Asn Val Leu Ala Arg Met Met Arg Pro 
225                 230                 235                 240 


Val Ser Asp Gln Val Gln Ile Lys Val Thr Met Asn Asp Glu Asp Met 
                245                 250                 255     


Asp Thr Tyr Val Phe Ala Val Gly Thr Arg Lys Ala Leu Val Arg Leu 
            260                 265                 270         


Gln Lys Glu Met Gln Asp Leu Ser Glu Phe Cys Ser Asp Lys Pro Lys 
        275                 280                 285             


Ser Gly Ala Lys Tyr Gly Leu Pro Asp Ser Leu Ala Ile Leu Ser Glu 
    290                 295                 300                 


Met Gly Glu Val Thr Asp Gly Met Met Asp Thr Lys Met Val His Phe 
305                 310                 315                 320 


Leu Thr His Tyr Ala Asp Lys Ile Glu Ser Val His Phe Ser Asp Gln 
                325                 330                 335     


Phe Ser Gly Pro Lys Ile Met Gln Glu Glu Gly Gln Pro Leu Lys Leu 
            340                 345                 350         


Pro Asp Thr Lys Arg Thr Leu Leu Phe Thr Phe Asn Val Pro Gly Ser 
        355                 360                 365             


Gly Asn Thr Tyr Pro Lys Asp Met Glu Ala Leu Leu Pro Leu Met Asn 
    370                 375                 380                 


Met Val Ile Tyr Ser Ile Asp Lys Ala Lys Lys Phe Arg Leu Asn Arg 
385                 390                 395                 400 


Glu Gly Lys Gln Lys Ala Asp Lys Asn Arg Ala Arg Val Glu Glu Asn 
                405                 410                 415     


Phe Leu Lys Leu Thr His Val Gln Arg Gln Glu Ala Ala Gln Ser Arg 
            420                 425                 430         


Arg Glu Glu Lys Lys Arg Ala Glu Lys Glu Arg Ile Met Asn Glu Glu 
        435                 440                 445             


Asp Pro Glu Lys Gln Arg Arg Leu Glu Glu Ala Ala Leu Arg Arg Glu 
    450                 455                 460                 


Gln Lys Lys Leu Glu Lys Lys Gln Met Lys Met Lys Gln Ile Lys Val 
465                 470                 475                 480 


Lys Ala Met 
            


<210> 16
<211> 3445
<212> DNA
<213> Homo sapiens

<400> 16
attatgtaat tttcccaaaa gccccacctc gcctcagccg ggcgggagag agggaggtct       60

cgcgctttcc ccggggttgc gtcccgcccc gcaggctgcg cgcaggcgct gacgagccgc      120

tcgcattcta cgtaacggac ggcggaggct acgtgaagag aggcgcggcg tgactgagct      180

acggttctgg ctgcgtccta gaggcatccg gggcagtaaa accgctgcga tcgcggaggc      240

ggcggccagg ccgagaggca ggccgggcag gggtgtcgga cgcagggcgc tgggccgggt      300

ttcggcttcg gccacagctt tttttctcaa ggtgcaatga aagccttcca cactttctgt      360

gttgtccttc tggtgtttgg gagtgtctct gaagccaagt ttgatgattt tgaggatgag      420

gaggacatag tagagtatga tgataatgac ttcgctgaat ttgaggatgt catggaagac      480

tctgttactg aatctcctca acgggtcata atcactgaag atgatgaaga tgagaccact      540

gtggagttgg aagggcagga tgaaaaccaa gaaggagatt ttgaagatgc agatacccag      600

gagggagata ctgagagtga accatatgat gatgaagaat ttgaaggtta tgaagacaaa      660

ccagatactt cttctagcaa aaataaagac ccaataacga ttgttgatgt tcctgcacac      720

ctccagaaca gctgggagag ttattatcta gaaattttga tggtgactgg tctgcttgct      780

tatatcatga attacatcat tgggaagaat aaaaacagtc gccttgcaca ggcctggttt      840

aacactcata gggagctttt ggagagcaac tttactttag tgggggatga tggaactaac      900

aaagaagcca caagcacagg aaagttgaac caggagaatg agcacatcta taacctgtgg      960

tgttctggtc gagtgtgctg tgagggcatg cttatccagc tgaggttcct caagagacaa     1020

gacttactga atgtcctggc ccggatgatg aggccagtga gtgatcaagt gcaaataaaa     1080

gtaaccatga atgatgaaga catggatacc tacgtatttg ctgttggcac acggaaagcc     1140

ttggtgcgac tacagaaaga gatgcaggat ttgagtgagt tttgtagtga taaacctaag     1200

tctggagcaa agtatggact gccggactct ttggccatcc tgtcagagat gggagaagtc     1260

acagacggaa tgatggatac aaagatggtt cactttctta cacactatgc tgacaagatt     1320

gaatctgttc atttttcaga ccagttctct ggtccaaaaa ttatgcaaga ggaaggtcag     1380

cctttaaagc tacctgacac taagaggaca ctgttgttta catttaatgt gcctggctca     1440

ggtaacactt acccaaagga tatggaggca ctgctacccc tgatgaacat ggtgatttat     1500

tctattgata aagccaaaaa gttccgactc aacagagaag gcaaacaaaa agcagataag     1560

aaccgtgccc gagtagaaga gaacttcttg aaactgacac atgtgcaaag acaggaagca     1620

gcacagtctc ggcgggagga gaaaaaaaga gcagagaagg agcgaatcat gaatgaggaa     1680

gatcctgaga aacagcgcag gctggaggag gctgcattga ggcgtgagca aaagaagttg     1740

gaaaagaagc aaatgaaaat gaaacaaatc aaagtgaaag ccatgtaaag ccatcccaga     1800

gatttgagtt ctgatgccac ctgtaagctc tgaattcaca ggaaacatga aaaacgccag     1860

tccatttctc aaccttaaat ttcagacagt cttgggcaac tgagaaatcc ttatttcatc     1920

atctactctg tttggggttt ggggttttac agagattgaa gatacctgga aagggctctg     1980

tttcaagaat ttttttttcc agataatcaa attattttga ttattttata aaaggaatga     2040

tctatgaaat ctgtgtaggt tttaaatatt ttaaaaatta taatacaaat catcagtgct     2100

tttagtactt cagtgtttaa agaaataccg tgaaatttat aggtagataa ccagattgtt     2160

gctttttgtt taaaccaagc agttgaaatg gctataaaga ctgactctaa accaagattc     2220

tgcaaataat gattggaatt gcacaataaa cattgcttga tgttttcttg tatgtctaca     2280

ttaaacttga gaaaaagtaa aaattagaac actgtatgta gtaatgaaat ttcagggacc     2340

cagaacataa tgtagtatat gtttttaggt gggagatgct gataacaaaa ttaataggaa     2400

gtctgtaggc attaggatac tgacatgtac atggaaaatt ctagggacag gagcatcatt     2460

ttttccttac ctgataccac gaaccagtga caacgtgaat gctgtatttt aagtggttgt     2520

atgtttattt tcttgagtaa caaatgcatg aaaaattaat gcttcaccta ggtaagatca     2580

ttggtctgtg tgaaatcaca aatgtttttt ccttcttggt tgctgcagcc tggtggatgt     2640

tcatggagaa gctctgttct ctatattatg gctgtgtgcc gttgcttctc cctctgcttt     2700

tatcttttcc acagttgagg ctgggtatgt tctttcaaag aaatggccat gaatatgtgt     2760

aagtatactt ttgaaaatga gctttcctaa actattgaga gttctttcca cctcttgcgg     2820

aaccaactct tggaggagag gcccatgtat ctgcacgagc acttagcttg ttcagatctc     2880

tgcattttat aaatgcttct taccaagaaa gcatttttag gtcattgctt gtaccaggta     2940

atttttgccg gggatgggta agggttgggt tttctggtgg gagtggggtg gtgggtattt     3000

tttgttgatg ctttagtgca ggcctgttct gaggcaataa caagttgctg tgaaaacagc     3060

atgtgctgct gcctttgtaa ctgcatggaa acttttcaca tgggtttttc tccaagttaa     3120

tacagaaata tgtaaactga gagatgcaaa tgtaatattt ttaacagttc atgaagttgt     3180

tattaaaata actaacataa aacttaatta ctttaatatt atataattat agtagtggcc     3240

ttgttttaca aacctttaaa ttacatttta gaaatcaaag ttgatagtct tagttatctt     3300

ttgagtaaga aaagctttcc taaagtccca tacatttgga ccatggcagc taattttgta     3360

acttaagcat tcatatgaac tacctatgga catctattaa agtgattgac aaaatctcaa     3420

aaaaaaaaaa aaaaaaaaaa aaaaa                                           3445


<210> 17
<211> 381
<212> PRT
<213> Homo sapiens

<400> 17
Met His Leu Leu Ala Ile Leu Phe Cys Ala Leu Trp Ser Ala Val Leu 
1               5                   10                  15      


Ala Glu Asn Ser Asp Asp Tyr Asp Leu Met Tyr Val Asn Leu Asp Asn 
            20                  25                  30          


Glu Ile Asp Asn Gly Leu His Pro Thr Glu Asp Pro Thr Pro Cys Ala 
        35                  40                  45              


Cys Gly Gln Glu His Ser Glu Trp Asp Lys Leu Phe Ile Met Leu Glu 
    50                  55                  60                  


Asn Ser Gln Met Arg Glu Arg Met Leu Leu Gln Ala Thr Asp Asp Val 
65                  70                  75                  80  


Leu Arg Gly Glu Leu Gln Arg Leu Arg Glu Glu Leu Gly Arg Leu Ala 
                85                  90                  95      


Glu Ser Leu Ala Arg Pro Cys Ala Pro Gly Ala Pro Ala Glu Ala Arg 
            100                 105                 110         


Leu Thr Ser Ala Leu Asp Glu Leu Leu Gln Ala Thr Arg Asp Ala Gly 
        115                 120                 125             


Arg Arg Leu Ala Arg Met Glu Gly Ala Glu Ala Gln Arg Pro Glu Glu 
    130                 135                 140                 


Ala Gly Arg Ala Leu Ala Ala Val Leu Glu Glu Leu Arg Gln Thr Arg 
145                 150                 155                 160 


Ala Asp Leu His Ala Val Gln Gly Trp Ala Ala Arg Ser Trp Leu Pro 
                165                 170                 175     


Ala Gly Cys Glu Thr Ala Ile Leu Phe Pro Met Arg Ser Lys Lys Ile 
            180                 185                 190         


Phe Gly Ser Val His Pro Val Arg Pro Met Arg Leu Glu Ser Phe Ser 
        195                 200                 205             


Ala Cys Ile Trp Val Lys Ala Thr Asp Val Leu Asn Lys Thr Ile Leu 
    210                 215                 220                 


Phe Ser Tyr Gly Thr Lys Arg Asn Pro Tyr Glu Ile Gln Leu Tyr Leu 
225                 230                 235                 240 


Ser Tyr Gln Ser Ile Val Phe Val Val Gly Gly Glu Glu Asn Lys Leu 
                245                 250                 255     


Val Ala Glu Ala Met Val Ser Leu Gly Arg Trp Thr His Leu Cys Gly 
            260                 265                 270         


Thr Trp Asn Ser Glu Glu Gly Leu Thr Ser Leu Trp Val Asn Gly Glu 
        275                 280                 285             


Leu Ala Ala Thr Thr Val Glu Met Ala Thr Gly His Ile Val Pro Glu 
    290                 295                 300                 


Gly Gly Ile Leu Gln Ile Gly Gln Glu Lys Asn Gly Cys Cys Val Gly 
305                 310                 315                 320 


Gly Gly Phe Asp Glu Thr Leu Ala Phe Ser Gly Arg Leu Thr Gly Phe 
                325                 330                 335     


Asn Ile Trp Asp Ser Val Leu Ser Asn Glu Glu Ile Arg Glu Thr Gly 
            340                 345                 350         


Gly Ala Glu Ser Cys His Ile Arg Gly Asn Ile Val Gly Trp Gly Val 
        355                 360                 365             


Thr Glu Ile Gln Pro His Gly Gly Ala Gln Tyr Val Ser 
    370                 375                 380     


<210> 18
<211> 1955
<212> DNA
<213> Homo sapiens

<400> 18
attcatcccc attcaggctt tcctcagcat ttattaagga ctctctgctc cagcctctca       60

ctctcactct cctccgctca aactcagctc acttgagagt ctcctcccgc cagctgtgga      120

aagaactttg cgtctctcca gcaatgcatc tccttgcgat tctgttttgt gctctctggt      180

ctgcagtgtt ggccgagaac tcggatgatt atgatctcat gtatgtgaat ttggacaacg      240

aaatagacaa tggactccat cccactgagg accccacgcc gtgcgcctgc ggtcaggagc      300

actcggaatg ggacaagctc ttcatcatgc tggagaactc gcagatgaga gagcgcatgc      360

tgctgcaagc cacggacgac gtcctgcggg gcgagctgca gaggctgcgg gaggagctgg      420

gccggctcgc ggaaagcctg gcgaggccgt gcgcgccggg ggctcccgca gaggccaggc      480

tgaccagtgc tctggacgag ctgctgcagg cgacccgcga cgcgggccgc aggctggcgc      540

gtatggaggg cgcggaggcg cagcgcccag aggaggcggg gcgcgccctg gccgcggtgc      600

tagaggagct gcggcagacg cgagccgacc tgcacgcggt gcagggctgg gctgcccgga      660

gctggctgcc ggcaggttgt gaaacagcta ttttattccc aatgcgttcc aagaagattt      720

ttggaagcgt gcatccagtg agaccaatga ggcttgagtc ttttagtgcc tgcatttggg      780

tcaaagccac agatgtatta aacaaaacca tcctgttttc ctatggcaca aagaggaatc      840

catatgaaat ccagctgtat ctcagctacc aatccatagt gtttgtggtg ggtggagagg      900

agaacaaact ggttgctgaa gccatggttt ccctgggaag gtggacccac ctgtgcggca      960

cctggaattc agaggaaggg ctcacatcct tgtgggtaaa tggtgaactg gcggctacca     1020

ctgttgagat ggccacaggt cacattgttc ctgagggagg aatcctgcag attggccaag     1080

aaaagaatgg ctgctgtgtg ggtggtggct ttgatgaaac attagccttc tctgggagac     1140

tcacaggctt caatatctgg gatagtgttc ttagcaatga agagataaga gagaccggag     1200

gagcagagtc ttgtcacatc cgggggaata ttgttgggtg gggagtcaca gagatccagc     1260

cacatggagg agctcagtat gtttcataaa tgttgtgaaa ctccacttga agccaaagaa     1320

agaaactcac acttaaaaca catgccagtt gggaaggtct gaaaactcag tgcataatag     1380

gaacacttga gactaatgaa agagagagtt gagaccaatc tttatttgta ctggccaaat     1440

actgaataaa cagttgaagg aaagacattg gaaaaagctt ttgaggataa tgttactaga     1500

ctttatgcca tggtgctttc agtttaatgc tgtgtctctg tcagataaac tctcaaataa     1560

ttaaaaagga ctgtattgtt gaacagaggg acaattgttt tacttttctt tggttaattt     1620

tgttttggcc agagatgaat tttacattgg aagaataaca aaataagatt tgttgtccat     1680

tgttcattgt tattggtatg taccttatta caaaaaaaag atgaaaacat atttatacta     1740

caaggtgact taacaactat aaatgtagtt tatgtgttat aatcgaatgt cacgtttttg     1800

agaagatagt catataagtt atattgcaaa agggatttgt attaatttaa gactattttt     1860

gtaaagctct actgtaaata aaatatttta taaaactagc tcacgtcatt taattataaa     1920

tttaagagat gttttggaaa aaaaaaaaaa aaaaa                                1955


<210> 19
<211> 243
<212> PRT
<213> Homo sapiens

<400> 19
Met Gly Gln Thr Ala Gly Asp Leu Gly Trp Arg Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Leu Val Gln Ala Gly Val Trp Gly Phe Pro Arg Pro 
            20                  25                  30          


Pro Gly Arg Pro Gln Leu Ser Leu Gln Glu Leu Arg Arg Glu Phe Thr 
        35                  40                  45              


Val Ser Leu His Leu Ala Arg Lys Leu Leu Ser Glu Val Arg Gly Gln 
    50                  55                  60                  


Ala His Arg Phe Ala Glu Ser His Leu Pro Gly Val Asn Leu Tyr Leu 
65                  70                  75                  80  


Leu Pro Leu Gly Glu Gln Leu Pro Asp Val Ser Leu Thr Phe Gln Ala 
                85                  90                  95      


Trp Arg Arg Leu Ser Asp Pro Glu Arg Leu Cys Phe Ile Ser Thr Thr 
            100                 105                 110         


Leu Gln Pro Phe His Ala Leu Leu Gly Gly Leu Gly Thr Gln Gly Arg 
        115                 120                 125             


Trp Thr Asn Met Glu Arg Met Gln Leu Trp Ala Met Arg Leu Asp Leu 
    130                 135                 140                 


Arg Asp Leu Gln Arg His Leu Arg Phe Gln Val Leu Ala Ala Gly Phe 
145                 150                 155                 160 


Asn Leu Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                165                 170                 175     


Arg Lys Gly Leu Leu Pro Gly Ala Leu Gly Ser Ala Leu Gln Gly Pro 
            180                 185                 190         


Ala Gln Val Ser Trp Pro Gln Leu Leu Ser Thr Tyr Arg Leu Leu His 
        195                 200                 205             


Ser Leu Glu Leu Val Leu Ser Arg Ala Val Arg Glu Leu Leu Leu Leu 
    210                 215                 220                 


Ser Lys Ala Gly His Ser Val Trp Pro Leu Gly Phe Pro Thr Leu Ser 
225                 230                 235                 240 


Pro Gln Pro 
            


<210> 20
<211> 1044
<212> DNA
<213> Homo sapiens

<400> 20
gaccaaagag gctgggcccc gccatgggcc agacggcagg cgaccttggc tggcggctca       60

gcctgttgct gcttcccttg ctcctggttc aagctggtgt ctggggattc ccaaggcccc      120

cagggaggcc ccagctgagc ctgcaggagc tgcggaggga gttcacagtc agcctgcatc      180

tcgccaggaa gctgctctcc gaggttcggg gccaggccca ccgctttgcg gaatctcacc      240

tgccaggagt gaacctgtac ctcctgcccc tgggagagca gctccctgat gtttccctga      300

ccttccaggc ctggcgccgc ctctctgacc cggagcgtct ctgcttcatc tccaccacgc      360

ttcagccctt ccatgccctg ctgggagggc tggggaccca gggccgctgg accaacatgg      420

agaggatgca gctgtgggcc atgaggctgg acctccgcga tctgcagcgg cacctccgct      480

tccaggtgct ggctgcagga ttcaacctcc cggaggagga ggaggaggaa gaggaggagg      540

aggaggagga gaggaagggg ctgctcccag gggcactggg cagcgcctta cagggcccgg      600

cccaggtgtc ctggccccag ctcctctcca cctaccgcct gctgcactcc ttggagctcg      660

tcttatctcg ggccgtgcgg gagttgctgc tgctgtccaa ggctgggcac tcagtctggc      720

ccttggggtt cccaacattg agcccccagc cctgatcggt ggcttcttag ccccctgccc      780

cccacccttt agaactttag gactggagtc ttggcatcag ggcagccttc gcatcatcag      840

ccttggacaa gggagggctc ttccagcccc ctgccccagg ctctacccag taactgaaag      900

cccctctggt cctcgccagc tatttatttc ttggatattt atttattgtt tagggagatg      960

atggtttatt tattgtcttg gggcccgatg gtcctcctcg ggccaagccc ccatgctggg     1020

tgcccaataa agcactctca tcca                                            1044


<210> 21
<211> 402
<212> PRT
<213> Homo sapiens

<400> 21
Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210> 22
<211> 3207
<212> DNA
<213> Homo sapiens

<400> 22
ggcccacaga ggagcacagc tgtgtttggc tgcagggcca agagcgctgt caagaagacc       60

cacacgcccc cctccagcag ctgaattcct gcagctcagc agccgccgcc agagcaggac      120

gaaccgccaa tcgcaaggca cctctgagaa cttcaggatg cagatgtctc cagccctcac      180

ctgcctagtc ctgggcctgg cccttgtctt tggtgaaggg tctgctgtgc accatccccc      240

atcctacgtg gcccacctgg cctcagactt cggggtgagg gtgtttcagc aggtggcgca      300

ggcctccaag gaccgcaacg tggttttctc accctatggg gtggcctcgg tgttggccat      360

gctccagctg acaacaggag gagaaaccca gcagcagatt caagcagcta tgggattcaa      420

gattgatgac aagggcatgg cccccgccct ccggcatctg tacaaggagc tcatggggcc      480

atggaacaag gatgagatca gcaccacaga cgcgatcttc gtccagcggg atctgaagct      540

ggtccagggc ttcatgcccc acttcttcag gctgttccgg agcacggtca agcaagtgga      600

cttttcagag gtggagagag ccagattcat catcaatgac tgggtgaaga cacacacaaa      660

aggtatgatc agcaacttgc ttgggaaagg agccgtggac cagctgacac ggctggtgct      720

ggtgaatgcc ctctacttca acggccagtg gaagactccc ttccccgact ccagcaccca      780

ccgccgcctc ttccacaaat cagacggcag cactgtctct gtgcccatga tggctcagac      840

caacaagttc aactatactg agttcaccac gcccgatggc cattactacg acatcctgga      900

actgccctac cacggggaca ccctcagcat gttcattgct gccccttatg aaaaagaggt      960

gcctctctct gccctcacca acattctgag tgcccagctc atcagccact ggaaaggcaa     1020

catgaccagg ctgccccgcc tcctggttct gcccaagttc tccctggaga ctgaagtcga     1080

cctcaggaag cccctagaga acctgggaat gaccgacatg ttcagacagt ttcaggctga     1140

cttcacgagt ctttcagacc aagagcctct ccacgtcgcg caggcgctgc agaaagtgaa     1200

gatcgaggtg aacgagagtg gcacggtggc ctcctcatcc acagctgtca tagtctcagc     1260

ccgcatggcc cccgaggaga tcatcatgga cagacccttc ctctttgtgg tccggcacaa     1320

ccccacagga acagtccttt tcatgggcca agtgatggaa ccctgaccct ggggaaagac     1380

gccttcatct gggacaaaac tggagatgca tcgggaaaga agaaactccg aagaaaagaa     1440

ttttagtgtt aatgactctt tctgaaggaa gagaagacat ttgccttttg ttaaaagatg     1500

gtaaaccaga tctgtctcca agaccttggc ctctccttgg aggaccttta ggtcaaactc     1560

cctagtctcc acctgagacc ctgggagaga agtttgaagc acaactccct taaggtctcc     1620

aaaccagacg gtgacgcctg cgggaccatc tggggcacct gcttccaccc gtctctctgc     1680

ccactcgggt ctgcagacct ggttcccact gaggcccttt gcaggatgga actacggggc     1740

ttacaggagc ttttgtgtgc ctggtagaaa ctatttctgt tccagtcaca ttgccatcac     1800

tcttgtactg cctgccaccg cggaggaggc tggtgacagg ccaaaggcca gtggaagaaa     1860

caccctttca tctcagagtc cactgtggca ctggccaccc ctccccagta caggggtgct     1920

gcaggtggca gagtgaatgt cccccatcat gtggcccaac tctcctggcc tggccatctc     1980

cctccccaga aacagtgtgc atgggttatt ttggagtgta ggtgacttgt ttactcattg     2040

aagcagattt ctgcttcctt ttatttttat aggaatagag gaagaaatgt cagatgcgtg     2100

cccagctctt caccccccaa tctcttggtg gggaggggtg tacctaaata tttatcatat     2160

ccttgccctt gagtgcttgt tagagagaaa gagaactact aaggaaaata atattattta     2220

aactcgctcc tagtgtttct ttgtggtctg tgtcaccgta tctcaggaag tccagccact     2280

tgactggcac acacccctcc ggacatccag cgtgacggag cccacactgc caccttgtgg     2340

ccgcctgaga ccctcgcgcc ccccgcgccc ctctttttcc ccttgatgga aattgaccat     2400

acaatttcat cctccttcag gggatcaaaa ggacggagtg gggggacaga gactcagatg     2460

aggacagagt ggtttccaat gtgttcaata gatttaggag cagaaatgca aggggctgca     2520

tgacctacca ggacagaact ttccccaatt acagggtgac tcacagccgc attggtgact     2580

cacttcaatg tgtcatttcc ggctgctgtg tgtgagcagt ggacacgtga ggggggggtg     2640

ggtgagagag acaggcagct cggattcaac taccttagat aatatttctg aaaacctacc     2700

agccagaggg tagggcacaa agatggatgt aatgcacttt gggaggccaa ggcgggagga     2760

ttgcttgagc ccaggagttc aagaccagcc tgggcaacat accaagaccc ccgtctcttt     2820

aaaaatatat atattttaaa tatacttaaa tatatatttc taatatcttt aaatatatat     2880

atatatttta aagaccaatt tatgggagaa ttgcacacag atgtgaaatg aatgtaatct     2940

aatagaagcc taatcagccc accatgttct ccactgaaaa atcctctttc tttggggttt     3000

ttctttcttt cttttttgat tttgcactgg acggtgacgt cagccatgta caggatccac     3060

aggggtggtg tcaaatgcta ttgaaattgt gttgaattgt atgctttttc acttttgata     3120

aataaacatg taaaaatgtt tcaaaaaaat aataaaataa ataaatacga agaatatgtc     3180

aggacagtca aaaaaaaaaa aaaaaaa                                         3207


<210> 23
<211> 387
<212> PRT
<213> Homo sapiens

<400> 23
Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


Gln Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala 
        35                  40                  45              


Ser Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln 
    50                  55                  60                  


Gln Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala 
65                  70                  75                  80  


Pro Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys 
                85                  90                  95      


Asp Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys 
            100                 105                 110         


Leu Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr 
        115                 120                 125             


Val Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile 
    130                 135                 140                 


Asn Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu 
145                 150                 155                 160 


Gly Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala 
                165                 170                 175     


Leu Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr 
            180                 185                 190         


His Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro 
        195                 200                 205             


Met Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro 
    210                 215                 220                 


Asp Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr 
225                 230                 235                 240 


Leu Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser 
                245                 250                 255     


Ala Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly 
            260                 265                 270         


Asn Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu 
        275                 280                 285             


Glu Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr 
    290                 295                 300                 


Asp Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln 
305                 310                 315                 320 


Glu Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val 
                325                 330                 335     


Asn Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser 
            340                 345                 350         


Ala Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe 
        355                 360                 365             


Val Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val 
    370                 375                 380                 


Met Glu Pro 
385         


<210> 24
<211> 3162
<212> DNA
<213> Homo sapiens

<400> 24
ggcccacaga ggagcacagc tgtgtttggc tgcagggcca agagcgctgt caagaagacc       60

cacacgcccc cctccagcag ctgaattcct gcagctcagc agccgccgcc agagcaggac      120

gaaccgccaa tcgcaaggca cctctgagaa cttcaggatg cagatgtctc cagccctcac      180

ctgcctagtc ctgggcctgg cccttgtctt tggtgaaggg tctgctgtgc accatccccc      240

atcctacgtg gcgcaggcct ccaaggaccg caacgtggtt ttctcaccct atggggtggc      300

ctcggtgttg gccatgctcc agctgacaac aggaggagaa acccagcagc agattcaagc      360

agctatggga ttcaagattg atgacaaggg catggccccc gccctccggc atctgtacaa      420

ggagctcatg gggccatgga acaaggatga gatcagcacc acagacgcga tcttcgtcca      480

gcgggatctg aagctggtcc agggcttcat gccccacttc ttcaggctgt tccggagcac      540

ggtcaagcaa gtggactttt cagaggtgga gagagccaga ttcatcatca atgactgggt      600

gaagacacac acaaaaggta tgatcagcaa cttgcttggg aaaggagccg tggaccagct      660

gacacggctg gtgctggtga atgccctcta cttcaacggc cagtggaaga ctcccttccc      720

cgactccagc acccaccgcc gcctcttcca caaatcagac ggcagcactg tctctgtgcc      780

catgatggct cagaccaaca agttcaacta tactgagttc accacgcccg atggccatta      840

ctacgacatc ctggaactgc cctaccacgg ggacaccctc agcatgttca ttgctgcccc      900

ttatgaaaaa gaggtgcctc tctctgccct caccaacatt ctgagtgccc agctcatcag      960

ccactggaaa ggcaacatga ccaggctgcc ccgcctcctg gttctgccca agttctccct     1020

ggagactgaa gtcgacctca ggaagcccct agagaacctg ggaatgaccg acatgttcag     1080

acagtttcag gctgacttca cgagtctttc agaccaagag cctctccacg tcgcgcaggc     1140

gctgcagaaa gtgaagatcg aggtgaacga gagtggcacg gtggcctcct catccacagc     1200

tgtcatagtc tcagcccgca tggcccccga ggagatcatc atggacagac ccttcctctt     1260

tgtggtccgg cacaacccca caggaacagt ccttttcatg ggccaagtga tggaaccctg     1320

accctgggga aagacgcctt catctgggac aaaactggag atgcatcggg aaagaagaaa     1380

ctccgaagaa aagaatttta gtgttaatga ctctttctga aggaagagaa gacatttgcc     1440

ttttgttaaa agatggtaaa ccagatctgt ctccaagacc ttggcctctc cttggaggac     1500

ctttaggtca aactccctag tctccacctg agaccctggg agagaagttt gaagcacaac     1560

tcccttaagg tctccaaacc agacggtgac gcctgcggga ccatctgggg cacctgcttc     1620

cacccgtctc tctgcccact cgggtctgca gacctggttc ccactgaggc cctttgcagg     1680

atggaactac ggggcttaca ggagcttttg tgtgcctggt agaaactatt tctgttccag     1740

tcacattgcc atcactcttg tactgcctgc caccgcggag gaggctggtg acaggccaaa     1800

ggccagtgga agaaacaccc tttcatctca gagtccactg tggcactggc cacccctccc     1860

cagtacaggg gtgctgcagg tggcagagtg aatgtccccc atcatgtggc ccaactctcc     1920

tggcctggcc atctccctcc ccagaaacag tgtgcatggg ttattttgga gtgtaggtga     1980

cttgtttact cattgaagca gatttctgct tccttttatt tttataggaa tagaggaaga     2040

aatgtcagat gcgtgcccag ctcttcaccc cccaatctct tggtggggag gggtgtacct     2100

aaatatttat catatccttg cccttgagtg cttgttagag agaaagagaa ctactaagga     2160

aaataatatt atttaaactc gctcctagtg tttctttgtg gtctgtgtca ccgtatctca     2220

ggaagtccag ccacttgact ggcacacacc cctccggaca tccagcgtga cggagcccac     2280

actgccacct tgtggccgcc tgagaccctc gcgccccccg cgcccctctt tttccccttg     2340

atggaaattg accatacaat ttcatcctcc ttcaggggat caaaaggacg gagtgggggg     2400

acagagactc agatgaggac agagtggttt ccaatgtgtt caatagattt aggagcagaa     2460

atgcaagggg ctgcatgacc taccaggaca gaactttccc caattacagg gtgactcaca     2520

gccgcattgg tgactcactt caatgtgtca tttccggctg ctgtgtgtga gcagtggaca     2580

cgtgaggggg gggtgggtga gagagacagg cagctcggat tcaactacct tagataatat     2640

ttctgaaaac ctaccagcca gagggtaggg cacaaagatg gatgtaatgc actttgggag     2700

gccaaggcgg gaggattgct tgagcccagg agttcaagac cagcctgggc aacataccaa     2760

gacccccgtc tctttaaaaa tatatatatt ttaaatatac ttaaatatat atttctaata     2820

tctttaaata tatatatata ttttaaagac caatttatgg gagaattgca cacagatgtg     2880

aaatgaatgt aatctaatag aagcctaatc agcccaccat gttctccact gaaaaatcct     2940

ctttctttgg ggtttttctt tctttctttt ttgattttgc actggacggt gacgtcagcc     3000

atgtacagga tccacagggg tggtgtcaaa tgctattgaa attgtgttga attgtatgct     3060

ttttcacttt tgataaataa acatgtaaaa atgtttcaaa aaaataataa aataaataaa     3120

tacgaagaat atgtcaggac agtcaaaaaa aaaaaaaaaa aa                        3162


<210> 25
<211> 149
<212> PRT
<213> Homo sapiens

<400> 25
Met Lys Val Arg Lys Ser Ser Thr Gln Glu Glu Ile Lys Lys Arg Lys 
1               5                   10                  15      


Lys Ala Val Leu Phe Cys Leu Ser Asp Asp Lys Arg Gln Ile Ile Val 
            20                  25                  30          


Glu Glu Ala Lys Gln Ile Leu Val Gly Asp Ile Gly Asp Thr Val Glu 
        35                  40                  45              


Asp Pro Tyr Thr Ser Phe Val Lys Leu Leu Pro Leu Asn Asp Cys Arg 
    50                  55                  60                  


Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys Glu 
65                  70                  75                  80  


Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys Ser 
                85                  90                  95      


Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe Thr 
            100                 105                 110         


Gly Ile Lys His Glu Trp Gln Val Asn Gly Leu Asp Asp Ile Lys Asp 
        115                 120                 125             


Arg Ser Thr Leu Gly Glu Lys Leu Gly Gly Asn Val Val Val Ser Leu 
    130                 135                 140                 


Glu Gly Lys Pro Leu 
145                 


<210> 26
<211> 3102
<212> DNA
<213> Homo sapiens

<400> 26
acagccgagg gcactatggt aagacgagcg cgctggccgg gaggccgcgg cgaggcgaga       60

aaagcccccc gcacggcccc gggagtgagg ccgccatttt aacctgattt tggcctccaa      120

ggcttctgga gttacagtga atgatgaagt catcaaagtt tttaatgata tgaaagtaag      180

gaaatcttct acacaagagg agatcaaaaa gagaaagaaa gcagttctct tctgtttaag      240

cgatgacaaa agacaaataa ttgtagagga agcaaagcag atcttggtgg gtgacattgg      300

tgatactgta gaggacccct acacatcttt tgtgaagttg ctacctctga atgattgccg      360

atatgctttg tacgatgcca catacgaaac aaaagagtct aagaaagaag acctagtatt      420

tatattctgg gctcctgaaa gtgcaccttt aaaaagcaag atgatttatg ctagctctaa      480

agatgccatt aaaaagaaat ttacaggtat taaacatgag tggcaagtaa atggcttgga      540

tgatattaag gaccgttcga cacttggaga gaaattggga ggcaatgtag tagtttcact      600

tgaaggaaaa ccattataaa atgacagtca agtgccatct ggatcttaag gagcttccat      660

ttctccagct cagtccattg gaatagtatt aggttttggt tttttgttgt atttccccct      720

ttccactggg cccttccaac acaatgaatg aaggaaatat catttattta agcagcctat      780

cagtgattgc cattagactg ttgaatactg ttacttttat atagaaccca aggaatgcct      840

tcctgtcata ttttagccaa aacaactggt tatatgcctc ccttgcagca agcactacaa      900

tgtatgtgat cgtcaatgtg aatagcttag aatactgcaa aggataagct aattgaatgc      960

cttgaaagta ttatccactg gtcagatggt caactttttt cagtattatt tatagttggc     1020

acttgattgc agttctgtga ggcttgagca ttcatacacc tcacctgcct tggcaagcct     1080

attttagtga tatggcagca cggatataac actatgcatt aaaagcactt tttgtaataa     1140

gtttaatatc ctaaaaggaa tgccaattaa gttttgttaa ctgtgtcatc aacttatcct     1200

agtacctcag tgttcattcc tgttacctgc atatcttctt aaaagaaata gctgttatta     1260

atgccttttt gttttccatt gagtgtacac tactgaataa gtgtaggagt tttatgttta     1320

ccatgtgagt cctgcaacac taaagatatt ttgaatatca gtcatgatgg caatttctgt     1380

ataaaagagc cttaaatgga acattgtttt gagatcaaac tccccaccct cacaaaaatg     1440

gccacgttgc aataaaaatt gtggcatatt acagaacgtt gccttgtttt ccttggaaat     1500

tttgcaaaat gttatgtgaa acaacttcta gggtaaaaac agctattact aatctctgca     1560

ctggtcattt gagaattttt tttgtacagc attcatgtgt gatattttcc agatttgttg     1620

gatctatttg gtttaaaaag tattctatct taaggccaac taatataaaa taccattgtt     1680

aaagaatggt acttttataa acattagtgt atttatttcc tatgtgttaa tatgaagatc     1740

agaaattatt ttttgcactt tggcataaat acttttcaat atctgatttg ttctctggat     1800

aaattagcat agttattttt ttattcacat ttacatttct aagtagttgt atagtagaag     1860

caggaagctc ttattgctta tttggtcgta atgaaaataa tttgtaaaat gtcctttaaa     1920

agtttaatga tacttctgat gtttcggaac agtcatttca cctactattt ctgaatatat     1980

tttgcaaatt gaattggaat aggaattgat aatagcagtc ttaaacatta gtagtgggat     2040

ttggctatgg tccagactgt gctccttata gagaatttga tctgctcagt gtgagcggtt     2100

tgctgttagc cagggctatt tatggcaaac acatgctttt gtatcttgtc atagttatcc     2160

acaaatggca aaactggact tgattctact ggtatgcaaa acaggcatgc tagtaagcag     2220

tcagtcgtgg ctcagaactt aaccccatag ctcagaggaa tgcttttagc agaaaacagg     2280

aaagaaaata tcccttaaaa attttttttg aatgtgtgga agtaatttta gtataattag     2340

attttttcca tatttttgaa agatttttca gatgtgaaca ttaaaaatag ggattaaatg     2400

tctaggcttc catttaaaat tatatgaatg gtttgggatc tttttgcact gagcaatttt     2460

atttcaggct tccagctgtc cctgtgagtt atcctggaca tttcgatggt ttttggtaag     2520

gccaaactct gataagcaaa acagagaata ctgacgtata cttaaccata tgtgtaactg     2580

atacttggca ccatggaatt tttcattgag ttatttcctc attcttttaa aaaataaggg     2640

actataaatc agttatgtag tatcttttgt ttttgtagct gattccttaa ctttcttgta     2700

tgcctctagt aatttcagag attaaatatt gctttaaact gtgatacttt gatttgctag     2760

attgacaaaa ctgatactaa tataattaag ttcatctttg aaatacatct ttgtgcgtag     2820

agccaaaaaa agagataaaa ttaataatag ttcacttgtt atttgagatt aatttggcat     2880

ttgaaatgat cattttattt tacaatcatt tataatgaat caatgttcca gttagcttta     2940

aaaggtatac ggtgctaatt agtaaaatat tgaaggcaat attttactgc tagcttgcaa     3000

agttatgaga gtttaaaaaa taaaatatat gaaaatatgt aaagctgttg agatgtgttt     3060

acttatactt cagaacatta aaagtttaaa aactggtatt tc                        3102


<210> 27
<211> 166
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Ser Gly Val Thr Val Asn Asp Glu Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Thr Gln Glu Glu Ile Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Asp Asp Lys Arg Gln Ile Ile 
        35                  40                  45              


Val Glu Glu Ala Lys Gln Ile Leu Val Gly Asp Ile Gly Asp Thr Val 
    50                  55                  60                  


Glu Asp Pro Tyr Thr Ser Phe Val Lys Leu Leu Pro Leu Asn Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe 
        115                 120                 125             


Thr Gly Ile Lys His Glu Trp Gln Val Asn Gly Leu Asp Asp Ile Lys 
    130                 135                 140                 


Asp Arg Ser Thr Leu Gly Glu Lys Leu Gly Gly Asn Val Val Val Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210> 28
<211> 3125
<212> DNA
<213> Homo sapiens

<400> 28
ggatgggaca acttgtattt gtccctttcg cttccacgtc caaacccctt taagaaggat       60

gaatgggcag gatgagttag actccttcgc tgtatcgtct actgattctt aaaatgtgac      120

aaatctgatt ggacgactta catggcttct ggagttacag tgaatgatga agtcatcaaa      180

gtttttaatg atatgaaagt aaggaaatct tctacacaag aggagatcaa aaagagaaag      240

aaagcagttc tcttctgttt aagcgatgac aaaagacaaa taattgtaga ggaagcaaag      300

cagatcttgg tgggtgacat tggtgatact gtagaggacc cctacacatc ttttgtgaag      360

ttgctacctc tgaatgattg ccgatatgct ttgtacgatg ccacatacga aacaaaagag      420

tctaagaaag aagacctagt atttatattc tgggctcctg aaagtgcacc tttaaaaagc      480

aagatgattt atgctagctc taaagatgcc attaaaaaga aatttacagg tattaaacat      540

gagtggcaag taaatggctt ggatgatatt aaggaccgtt cgacacttgg agagaaattg      600

ggaggcaatg tagtagtttc acttgaagga aaaccattat aaaatgacag tcaagtgcca      660

tctggatctt aaggagcttc catttctcca gctcagtcca ttggaatagt attaggtttt      720

ggttttttgt tgtatttccc cctttccact gggcccttcc aacacaatga atgaaggaaa      780

tatcatttat ttaagcagcc tatcagtgat tgccattaga ctgttgaata ctgttacttt      840

tatatagaac ccaaggaatg ccttcctgtc atattttagc caaaacaact ggttatatgc      900

ctcccttgca gcaagcacta caatgtatgt gatcgtcaat gtgaatagct tagaatactg      960

caaaggataa gctaattgaa tgccttgaaa gtattatcca ctggtcagat ggtcaacttt     1020

tttcagtatt atttatagtt ggcacttgat tgcagttctg tgaggcttga gcattcatac     1080

acctcacctg ccttggcaag cctattttag tgatatggca gcacggatat aacactatgc     1140

attaaaagca ctttttgtaa taagtttaat atcctaaaag gaatgccaat taagttttgt     1200

taactgtgtc atcaacttat cctagtacct cagtgttcat tcctgttacc tgcatatctt     1260

cttaaaagaa atagctgtta ttaatgcctt tttgttttcc attgagtgta cactactgaa     1320

taagtgtagg agttttatgt ttaccatgtg agtcctgcaa cactaaagat attttgaata     1380

tcagtcatga tggcaatttc tgtataaaag agccttaaat ggaacattgt tttgagatca     1440

aactccccac cctcacaaaa atggccacgt tgcaataaaa attgtggcat attacagaac     1500

gttgccttgt tttccttgga aattttgcaa aatgttatgt gaaacaactt ctagggtaaa     1560

aacagctatt actaatctct gcactggtca tttgagaatt ttttttgtac agcattcatg     1620

tgtgatattt tccagatttg ttggatctat ttggtttaaa aagtattcta tcttaaggcc     1680

aactaatata aaataccatt gttaaagaat ggtactttta taaacattag tgtatttatt     1740

tcctatgtgt taatatgaag atcagaaatt attttttgca ctttggcata aatacttttc     1800

aatatctgat ttgttctctg gataaattag catagttatt tttttattca catttacatt     1860

tctaagtagt tgtatagtag aagcaggaag ctcttattgc ttatttggtc gtaatgaaaa     1920

taatttgtaa aatgtccttt aaaagtttaa tgatacttct gatgtttcgg aacagtcatt     1980

tcacctacta tttctgaata tattttgcaa attgaattgg aataggaatt gataatagca     2040

gtcttaaaca ttagtagtgg gatttggcta tggtccagac tgtgctcctt atagagaatt     2100

tgatctgctc agtgtgagcg gtttgctgtt agccagggct atttatggca aacacatgct     2160

tttgtatctt gtcatagtta tccacaaatg gcaaaactgg acttgattct actggtatgc     2220

aaaacaggca tgctagtaag cagtcagtcg tggctcagaa cttaacccca tagctcagag     2280

gaatgctttt agcagaaaac aggaaagaaa atatccctta aaaatttttt ttgaatgtgt     2340

ggaagtaatt ttagtataat tagatttttt ccatattttt gaaagatttt tcagatgtga     2400

acattaaaaa tagggattaa atgtctaggc ttccatttaa aattatatga atggtttggg     2460

atctttttgc actgagcaat tttatttcag gcttccagct gtccctgtga gttatcctgg     2520

acatttcgat ggtttttggt aaggccaaac tctgataagc aaaacagaga atactgacgt     2580

atacttaacc atatgtgtaa ctgatacttg gcaccatgga atttttcatt gagttatttc     2640

ctcattcttt taaaaaataa gggactataa atcagttatg tagtatcttt tgtttttgta     2700

gctgattcct taactttctt gtatgcctct agtaatttca gagattaaat attgctttaa     2760

actgtgatac tttgatttgc tagattgaca aaactgatac taatataatt aagttcatct     2820

ttgaaataca tctttgtgcg tagagccaaa aaaagagata aaattaataa tagttcactt     2880

gttatttgag attaatttgg catttgaaat gatcatttta ttttacaatc atttataatg     2940

aatcaatgtt ccagttagct ttaaaaggta tacggtgcta attagtaaaa tattgaaggc     3000

aatattttac tgctagcttg caaagttatg agagtttaaa aaataaaata tatgaaaata     3060

tgtaaagctg ttgagatgtg tttacttata cttcagaaca ttaaaagttt aaaaactggt     3120

atttc                                                                 3125


<210> 29
<211> 166
<212> PRT
<213> Homo sapiens

<400> 29
Met Ala Ser Gly Val Thr Val Asn Asp Glu Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Thr Gln Glu Glu Ile Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Asp Asp Lys Arg Gln Ile Ile 
        35                  40                  45              


Val Glu Glu Ala Lys Gln Ile Leu Val Gly Asp Ile Gly Asp Thr Val 
    50                  55                  60                  


Glu Asp Pro Tyr Thr Ser Phe Val Lys Leu Leu Pro Leu Asn Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe 
        115                 120                 125             


Thr Gly Ile Lys His Glu Trp Gln Val Asn Gly Leu Asp Asp Ile Lys 
    130                 135                 140                 


Asp Arg Ser Thr Leu Gly Glu Lys Leu Gly Gly Asn Val Val Val Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210> 30
<211> 3267
<212> DNA
<213> Homo sapiens

<400> 30
cgcgctctga ggtcaggccg aggacgcgga cagccgggga gccggggccg cgagacagaa       60

gggccggcct gggagcgggt ggcgccggct ggggaccagg cgtgcccacg tgaccgcccc      120

gcccgctgcc tgcggcccgc cgagccccgc cacctccctc gggctgcagc tcccggcgtg      180

ccccgcactc tccgctgccc acccgctcgc ccgcccctcc ttctcctccc agtgccacag      240

agccgaagcc cgagctgccg ccgcagccac agccgagggc actatggctt ctggagttac      300

agtgaatgat gaagtcatca aagtttttaa tgatatgaaa gtaaggaaat cttctacaca      360

agaggagatc aaaaagagaa agaaagcagt tctcttctgt ttaagcgatg acaaaagaca      420

aataattgta gaggaagcaa agcagatctt ggtgggtgac attggtgata ctgtagagga      480

cccctacaca tcttttgtga agttgctacc tctgaatgat tgccgatatg ctttgtacga      540

tgccacatac gaaacaaaag agtctaagaa agaagaccta gtatttatat tctgggctcc      600

tgaaagtgca cctttaaaaa gcaagatgat ttatgctagc tctaaagatg ccattaaaaa      660

gaaatttaca ggtattaaac atgagtggca agtaaatggc ttggatgata ttaaggaccg      720

ttcgacactt ggagagaaat tgggaggcaa tgtagtagtt tcacttgaag gaaaaccatt      780

ataaaatgac agtcaagtgc catctggatc ttaaggagct tccatttctc cagctcagtc      840

cattggaata gtattaggtt ttggtttttt gttgtatttc cccctttcca ctgggccctt      900

ccaacacaat gaatgaagga aatatcattt atttaagcag cctatcagtg attgccatta      960

gactgttgaa tactgttact tttatataga acccaaggaa tgccttcctg tcatatttta     1020

gccaaaacaa ctggttatat gcctcccttg cagcaagcac tacaatgtat gtgatcgtca     1080

atgtgaatag cttagaatac tgcaaaggat aagctaattg aatgccttga aagtattatc     1140

cactggtcag atggtcaact tttttcagta ttatttatag ttggcacttg attgcagttc     1200

tgtgaggctt gagcattcat acacctcacc tgccttggca agcctatttt agtgatatgg     1260

cagcacggat ataacactat gcattaaaag cactttttgt aataagttta atatcctaaa     1320

aggaatgcca attaagtttt gttaactgtg tcatcaactt atcctagtac ctcagtgttc     1380

attcctgtta cctgcatatc ttcttaaaag aaatagctgt tattaatgcc tttttgtttt     1440

ccattgagtg tacactactg aataagtgta ggagttttat gtttaccatg tgagtcctgc     1500

aacactaaag atattttgaa tatcagtcat gatggcaatt tctgtataaa agagccttaa     1560

atggaacatt gttttgagat caaactcccc accctcacaa aaatggccac gttgcaataa     1620

aaattgtggc atattacaga acgttgcctt gttttccttg gaaattttgc aaaatgttat     1680

gtgaaacaac ttctagggta aaaacagcta ttactaatct ctgcactggt catttgagaa     1740

ttttttttgt acagcattca tgtgtgatat tttccagatt tgttggatct atttggttta     1800

aaaagtattc tatcttaagg ccaactaata taaaatacca ttgttaaaga atggtacttt     1860

tataaacatt agtgtattta tttcctatgt gttaatatga agatcagaaa ttattttttg     1920

cactttggca taaatacttt tcaatatctg atttgttctc tggataaatt agcatagtta     1980

tttttttatt cacatttaca tttctaagta gttgtatagt agaagcagga agctcttatt     2040

gcttatttgg tcgtaatgaa aataatttgt aaaatgtcct ttaaaagttt aatgatactt     2100

ctgatgtttc ggaacagtca tttcacctac tatttctgaa tatattttgc aaattgaatt     2160

ggaataggaa ttgataatag cagtcttaaa cattagtagt gggatttggc tatggtccag     2220

actgtgctcc ttatagagaa tttgatctgc tcagtgtgag cggtttgctg ttagccaggg     2280

ctatttatgg caaacacatg cttttgtatc ttgtcatagt tatccacaaa tggcaaaact     2340

ggacttgatt ctactggtat gcaaaacagg catgctagta agcagtcagt cgtggctcag     2400

aacttaaccc catagctcag aggaatgctt ttagcagaaa acaggaaaga aaatatccct     2460

taaaaatttt ttttgaatgt gtggaagtaa ttttagtata attagatttt ttccatattt     2520

ttgaaagatt tttcagatgt gaacattaaa aatagggatt aaatgtctag gcttccattt     2580

aaaattatat gaatggtttg ggatcttttt gcactgagca attttatttc aggcttccag     2640

ctgtccctgt gagttatcct ggacatttcg atggtttttg gtaaggccaa actctgataa     2700

gcaaaacaga gaatactgac gtatacttaa ccatatgtgt aactgatact tggcaccatg     2760

gaatttttca ttgagttatt tcctcattct tttaaaaaat aagggactat aaatcagtta     2820

tgtagtatct tttgtttttg tagctgattc cttaactttc ttgtatgcct ctagtaattt     2880

cagagattaa atattgcttt aaactgtgat actttgattt gctagattga caaaactgat     2940

actaatataa ttaagttcat ctttgaaata catctttgtg cgtagagcca aaaaaagaga     3000

taaaattaat aatagttcac ttgttatttg agattaattt ggcatttgaa atgatcattt     3060

tattttacaa tcatttataa tgaatcaatg ttccagttag ctttaaaagg tatacggtgc     3120

taattagtaa aatattgaag gcaatatttt actgctagct tgcaaagtta tgagagttta     3180

aaaaataaaa tatatgaaaa tatgtaaagc tgttgagatg tgtttactta tacttcagaa     3240

cattaaaagt ttaaaaactg gtatttc                                         3267


<210> 31
<211> 480
<212> PRT
<213> Homo sapiens

<400> 31
Met Lys Arg Ser Val Ala Val Trp Leu Leu Val Gly Leu Ser Leu Gly 
1               5                   10                  15      


Val Pro Gln Phe Gly Lys Gly Asp Ile Cys Asp Pro Asn Pro Cys Glu 
            20                  25                  30          


Asn Gly Gly Ile Cys Leu Pro Gly Leu Ala Asp Gly Ser Phe Ser Cys 
        35                  40                  45              


Glu Cys Pro Asp Gly Phe Thr Asp Pro Asn Cys Ser Ser Val Val Glu 
    50                  55                  60                  


Val Ala Ser Asp Glu Glu Glu Pro Thr Ser Ala Gly Pro Cys Thr Pro 
65                  70                  75                  80  


Asn Pro Cys His Asn Gly Gly Thr Cys Glu Ile Ser Glu Ala Tyr Arg 
                85                  90                  95      


Gly Asp Thr Phe Ile Gly Tyr Val Cys Lys Cys Pro Arg Gly Phe Asn 
            100                 105                 110         


Gly Ile His Cys Gln His Asn Ile Asn Glu Cys Glu Val Glu Pro Cys 
        115                 120                 125             


Lys Asn Gly Gly Ile Cys Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu 
    130                 135                 140                 


Cys Pro Gly Glu Phe Met Gly Arg Asn Cys Gln Tyr Lys Cys Ser Gly 
145                 150                 155                 160 


Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala 
                165                 170                 175     


Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr 
            180                 185                 190         


Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala 
        195                 200                 205             


Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met 
    210                 215                 220                 


Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro 
225                 230                 235                 240 


Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr 
                245                 250                 255     


Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg 
            260                 265                 270         


Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro 
        275                 280                 285             


Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His 
    290                 295                 300                 


Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser 
305                 310                 315                 320 


Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile Thr 
                325                 330                 335     


Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp Glu 
            340                 345                 350         


Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp Thr 
        355                 360                 365             


Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu Val 
    370                 375                 380                 


Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly 
385                 390                 395                 400 


His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly 
                405                 410                 415     


Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys Val 
            420                 425                 430         


Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile Asp 
        435                 440                 445             


Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser Trp Tyr 
    450                 455                 460                 


Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys Thr Glu Glu Glu 
465                 470                 475                 480 


<210> 32
<211> 2974
<212> DNA
<213> Homo sapiens

<400> 32
agaagccccg cagccgccgc gcggagaaca gcgacagccg agcgcccggt ccgcctgtct       60

gccggtgggt ctgcctgccc gcgcagcaga cccggggcgg ccgcgggagc ccgcgccccg      120

cccgccgcgc ctctgccggg acccacccgc agcggagggc tgagcccgcc ggcggctccc      180

cggagctcac ccacctccgc gcgccggagc gcaggcaaaa ggggaggaaa ggctcctctc      240

tttagtcacc actctcgccc tctccaagaa tttgtttaac aaagcgctga ggaaagagaa      300

cgtcttcttg aattctttag taggggcgga gtctgctgct gccctgcgct gccacctcgg      360

ctacactgcc ctccgcgacg acccctgacc agccggggtc acgtccggga gacgggatca      420

tgaagcgctc ggtagccgtc tggctcttgg tcgggctcag cctcggtgtc ccccagttcg      480

gcaaaggtga tatttgtgat cccaatccat gtgaaaatgg aggtatctgt ttgccaggat      540

tggctgatgg ttccttttcc tgtgagtgtc cagatggctt cacagacccc aactgttcta      600

gtgttgtgga ggttgcatca gatgaagaag aaccaacttc agcaggtccc tgcactccta      660

atccatgcca taatggagga acctgtgaaa taagtgaagc ataccgaggg gatacattca      720

taggctatgt ttgtaaatgt ccccgaggat ttaatgggat tcactgtcag cacaacataa      780

atgaatgcga agttgagcct tgcaaaaatg gtggaatatg tacagatctt gttgctaact      840

attcctgtga gtgcccaggc gaatttatgg gaagaaattg tcaatacaaa tgctcaggcc      900

cactgggaat tgaaggtgga attatatcaa accagcaaat cacagcttcc tctactcacc      960

gagctctttt tggactccaa aaatggtatc cctactatgc acgtcttaat aagaaggggc     1020

ttataaatgc gtggacagct gcagaaaatg acagatggcc gtggattcag ataaatttgc     1080

aaaggaaaat gagagttact ggtgtgatta cccaaggagc caagaggatt ggaagcccag     1140

agtatataaa atcctacaaa attgcctaca gtaatgatgg aaagacttgg gcaatgtaca     1200

aagtgaaagg caccaatgaa gacatggtgt ttcgtggaaa cattgataac aacactccat     1260

atgctaactc tttcacaccc cccataaaag ctcagtatgt aagactctat ccccaagttt     1320

gtcgaagaca ttgcactttg cgaatggaac ttcttggctg tgaactgtcg ggttgttctg     1380

agcctctggg tatgaaatca ggacatatac aagactatca gatcactgcc tccagcatct     1440

tcagaacgct caacatggac atgttcactt gggaaccaag gaaagctcgg ctggacaagc     1500

aaggcaaagt gaatgcctgg acctctggcc acaatgacca gtcacaatgg ttacaggtgg     1560

atcttcttgt tccaaccaaa gtgactggca tcattacaca aggagctaaa gattttggtc     1620

atgtacagtt tgttggctcc tacaaactgg cttacagcaa tgatggagaa cactggactg     1680

tataccagga tgaaaagcaa agaaaagata aggttttcca gggaaatttt gacaatgaca     1740

ctcacagaaa aaatgtcatc gaccctccca tctatgcacg acacataaga atccttcctt     1800

ggtcctggta cgggaggatc acattgcggt cagagctgct gggctgcaca gaggaggaat     1860

gaggggaggc tacatttcac aaccctcttc cctatttccc taaaagtatc tccatggaat     1920

gaactgtgca aaatctgtag gaaactgaat ggtttttttt tttttttcat gaaaaagtgc     1980

tcaaattatg gtaggcaact aacggtgttt ttaagggggt ctaagcctgc cttttcaatg     2040

atttaatttg attttatttt atccgtcaaa tctcttaagt aacaacacat taagtgtgaa     2100

ttacttttct ctcattgttt cctgaattat tcgcattggt agaaatatat tagggaaaga     2160

aagtagcctt ctttttatag caagagtaaa aaagtctcaa agtcatcaaa taagagcaag     2220

agttgataga gcttttacaa tcaatactca cctaattctg ataaaaggaa tactgcaatg     2280

ttagcaataa gtttttttct tctgtaatga ctctacgtta tcctgtttcc ctgtgcctac     2340

caaacactgt caatgtttat tacaaaattt taaagaagaa tatgtaacat gcagtactga     2400

tattataatt ctcattttac tttcattatt tctaataaga gattatgtga cttctttttc     2460

ttttagttct attctacatt cttaatattg tatattacct gaataattca atttttttct     2520

aattgaattt cctattagtt gactaaaaga agtgtcatgt ttactcatat atgtagaaca     2580

tgactgccta tcagtagatt gatctgtatt taatattcgt taattaaatc tgcagtttta     2640

tttttgaagg aagccataac tatttaattt ccaaataatt gcttcataaa gaatcccata     2700

ctctcagttt gcacaaaaga acaaaaaata tatatgtctc tttaaattta aatcttcatt     2760

tagatggtaa ttacatatcc ttatatttac tttaaaaaat cggcttattt gtttatttta     2820

taaaaaattt agcaaagaaa tattaatata gtgctgcata gtttggccaa gcatactcat     2880

catttctttg ttcagctcca catttcctgt gaaactaaca tcttattgag atttgaaact     2940

ggtggtagtt tcccaggaag gcacaggtgg agtt                                 2974


<210> 33
<211> 461
<212> PRT
<213> Homo sapiens

<400> 33
Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 
        115                 120                 125             


Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 
    130                 135                 140                 


Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 
145                 150                 155                 160 


Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 
                165                 170                 175     


Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 
            180                 185                 190         


Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 
        195                 200                 205             


Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 
    210                 215                 220                 


Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 
225                 230                 235                 240 


Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser 
                245                 250                 255     


Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu 
            260                 265                 270         


Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu 
        275                 280                 285             


Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val 
    290                 295                 300                 


Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser 
305                 310                 315                 320 


Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val 
                325                 330                 335     


Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu 
            340                 345                 350         


Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu 
        355                 360                 365             


Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala 
    370                 375                 380                 


Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro 
                405                 410                 415     


Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro 
            420                 425                 430         


Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu 
        435                 440                 445             


Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu 
    450                 455                 460     


<210> 34
<211> 2585
<212> DNA
<213> Homo sapiens

<400> 34
gcggaagtta tttttccccc ggccggcagg gagttgtagt tatctttgaa agccttctct       60

ctcttttggc ataggcggga aatgtggcgt caagaggctg ggattccgag aaagaagcga      120

ggctttcacg aaaatgcgag cggcttcggc aaggggcggg gccgctggac gtggatgaaa      180

gctacagagc cagcgtggac caatcagacc tctttggggc ggggcctctg tggataagtg      240

ggcgtggtct aggggggaag tcaccaagaa cgcaccggag gtccttgccc gccctggaaa      300

acgccctctg cggtgaagga gagaccacac tgccatgcct ccctctgggc cccgaggaac      360

cctccttctg ttgccgctgc tgctgctgct cctgcttcgc gccgtgctgg ctgtccccct      420

ggagcgaggg gcgcccaaca aggaggagac ccctgcgact gagagtcccg acacaggcct      480

gtactaccac cggtacctcc aggaggtcat cgatgtactg gagacggatg ggcatttccg      540

agagaagctg caggctgcca atgcggagga catcaagagc gggaagctga gccgagagct      600

ggactttgtc agccaccacg tccgcaccaa gctggatgag ctcaagcgac aggaggtgtc      660

acggctgcgg atgctgctca aggccaagat ggacgccgag caggatccca atgtacaggt      720

ggatcatctg aatctcctga aacagtttga acacctggac cctcagaacc agcatacatt      780

cgaggcccgc gacctggagc tgctgatcca gacggccacc cgggaccttg cccagtacga      840

cgcagcccat catgaagagt tcaagcgcta cgagatgctt aaggaacacg agagacggcg      900

ttatctggag tcactgggag aggagcagag aaaggaggcg gagaggaagc tggaagagca      960

acagcgccgg caccgcgagc accctaaagt caacgtgcct ggcagccaag cccagttgaa     1020

ggaggtgtgg gaggagctgg atggactgga ccccaacagg tttaacccca agaccttctt     1080

catactgcat gatatcaaca gtgatggtgt cctggatgag caggagctgg aggcactctt     1140

caccaaggag ctggagaaag tgtacgaccc aaagaatgag gaggacgaca tgcgggagat     1200

ggaggaggag cgactgcgca tgcgggagca tgtgatgaag aatgtggaca ccaaccagga     1260

ccgcctcgtg accctggagg agttcctcgc atccactcag aggaaggagt ttggggacac     1320

cggggagggc tgggagacag tggagatgca ccctgcctac accgaggaag agctgaggcg     1380

ctttgaagag gagctggctg cccgggaggc agagctgaat gccaaggccc agcgcctcag     1440

ccaggagaca gaggctctag ggcggtccca gggccgcctg gaggcccaga agagagagct     1500

gcagcaggct gtgctgcaca tggagcagcg gaagcagcag cagcagcagc agcaaggcca     1560

caaggccccg gctgcccacc ctgaggggca gctcaagttc cacccagaca cagacgatgt     1620

acctgtccca gctccagccg gtgaccagaa ggaggtggac acttcagaaa agaaacttct     1680

cgagcggctc cctgaggttg aggtgcccca gcatctgtga tcctccggga ccccagccct     1740

caggattcct gatgctccaa ggcgactgat gggcgctgga tgaagtggca cagtcagctt     1800

ccctgggggc tggtgtcatg ttgggctcct ggggcggggg cacggcctgg catttcacgc     1860

attgctgcca ccccaggtcc acctgtctcc actttcacag cctccaagtc tgtggctctt     1920

cccttctgtc ctccgagggg cttgccttct ctcgtgtcca gtgaggtgct cagtgatcgg     1980

cttaacttag agaagcccgc cccctcccct tctccgtctg tcccaagagg gtctgctctg     2040

agcctgcgtt cctaggtggc tcggcctcag ctgcctgggt tgtggccgcc ctagcatcct     2100

gtatgcccac agctactgga atccccgctg ctgctccggg ccaagcttct ggttgattaa     2160

tgagggcatg gggtggtccc tcaagacctt cccctacctt ttgtggaacc agtgatgcct     2220

caaagacagt gtcccctcca cagctgggtg ccaggggcag gggatcctca gtatagccgg     2280

tgaaccctga taccaggagc ctgggcctcc ctgaacccct ggcttccagc catctcatcg     2340

ccagcctcct cctggacctc ttggccccca gccccttccc cacacagccc cagaagggtc     2400

ccagagctga ccccactcca ggacctaggc ccagcccctc agcctcatct ggagcccctg     2460

aagaccagtc ccacccacct ttctggcctc atctgacact gctccgcatc ctgctgtgtg     2520

tcctgttcca tgttccggtt ccatccaaat acactttctg gaacaaatgc atggctccaa     2580

aaaaa                                                                 2585


<210> 35
<211> 3973
<212> DNA
<213> Homo sapiens

<400> 35
gggctggggg agggtatata agccgagtag gcgacggtga ggtcgacgcc ggccaagaca       60

gcacagacag attgacctat tggggtgttt cgcgagtgtg agagggaagc gccgcggcct      120

gtatttctag acctgccctt cgcctggttc gtggcgcctt gtgaccccgg gcccctgccg      180

cctgcaagtc ggaaattgcg ctgtgctcct gtgctacggc ctgtggctgg actgcctgct      240

gctgcccaac tggctggcaa gatgaagctc tccctggtgg ccgcgatgct gctgctgctc      300

agcgcggcgc gggccgagga ggaggacaag aaggaggacg tgggcacggt ggtcggcatc      360

gacctgggga ccacctactc ctgcgtcggc gtgttcaaga acggccgcgt ggagatcatc      420

gccaacgatc agggcaaccg catcacgccg tcctatgtcg ccttcactcc tgaaggggaa      480

cgtctgattg gcgatgccgc caagaaccag ctcacctcca accccgagaa cacggtcttt      540

gacgccaagc ggctcatcgg ccgcacgtgg aatgacccgt ctgtgcagca ggacatcaag      600

ttcttgccgt tcaaggtggt tgaaaagaaa actaaaccat acattcaagt tgatattgga      660

ggtgggcaaa caaagacatt tgctcctgaa gaaatttctg ccatggttct cactaaaatg      720

aaagaaaccg ctgaggctta tttgggaaag aaggttaccc atgcagttgt tactgtacca      780

gcctatttta atgatgccca acgccaagca accaaagacg ctggaactat tgctggccta      840

aatgttatga ggatcatcaa cgagcctacg gcagctgcta ttgcttatgg cctggataag      900

agggaggggg agaagaacat cctggtgttt gacctgggtg gcggaacctt cgatgtgtct      960

cttctcacca ttgacaatgg tgtcttcgaa gttgtggcca ctaatggaga tactcatctg     1020

ggtggagaag actttgacca gcgtgtcatg gaacacttca tcaaactgta caaaaagaag     1080

acgggcaaag atgtcaggaa agacaataga gctgtgcaga aactccggcg cgaggtagaa     1140

aaggccaaac gggccctgtc ttctcagcat caagcaagaa ttgaaattga gtccttctat     1200

gaaggagaag acttttctga gaccctgact cgggccaaat ttgaagagct caacatggat     1260

ctgttccggt ctactatgaa gcccgtccag aaagtgttgg aagattctga tttgaagaag     1320

tctgatattg atgaaattgt tcttgttggt ggctcgactc gaattccaaa gattcagcaa     1380

ctggttaaag agttcttcaa tggcaaggaa ccatcccgtg gcataaaccc agatgaagct     1440

gtagcgtatg gtgctgctgt ccaggctggt gtgctctctg gtgatcaaga tacaggtgac     1500

ctggtactgc ttgatgtatg tccccttaca cttggtattg aaactgtggg aggtgtcatg     1560

accaaactga ttccaaggaa cacagtggtg cctaccaaga agtctcagat cttttctaca     1620

gcttctgata atcaaccaac tgttacaatc aaggtctatg aaggtgaaag acccctgaca     1680

aaagacaatc atcttctggg tacatttgat ctgactggaa ttcctcctgc tcctcgtggg     1740

gtcccacaga ttgaagtcac ctttgagata gatgtgaatg gtattcttcg agtgacagct     1800

gaagacaagg gtacagggaa caaaaataag atcacaatca ccaatgacca gaatcgcctg     1860

acacctgaag aaatcgaaag gatggttaat gatgctgaga agtttgctga ggaagacaaa     1920

aagctcaagg agcgcattga tactagaaat gagttggaaa gctatgccta ttctctaaag     1980

aatcagattg gagataaaga aaagctggga ggtaaacttt cctctgaaga taaggagacc     2040

atggaaaaag ctgtagaaga aaagattgaa tggctggaaa gccaccaaga tgctgacatt     2100

gaagacttca aagctaagaa gaaggaactg gaagaaattg ttcaaccaat tatcagcaaa     2160

ctctatggaa gtgcaggccc tcccccaact ggtgaagagg atacagcaga aaaagatgag     2220

ttgtagacac tgatctgcta gtgctgtaat attgtaaata ctggactcag gaacttttgt     2280

taggaaaaaa ttgaaagaac ttaagtctcg aatgtaattg gaatcttcac ctcagagtgg     2340

agttgaaact gctatagcct aagcggctgt ttactgcttt tcattagcag ttgctcacat     2400

gtctttgggt gggggggaga agaagaattg gccatcttaa aaagcgggta aaaaacctgg     2460

gttagggtgt gtgttcacct tcaaaatgtt ctatttaaca actgggtcat gtgcatctgg     2520

tgtaggaagt tttttctacc ataagtgaca ccaataaatg tttgttattt acactggtct     2580

aatgtttgtg agaagcttct aattagatca attacttatt ttaggaaatt taagactaga     2640

tactcgtgtg tggggtgagg ggagggagta tttggtatgt tgggataagg aaacacttct     2700

atttaatgct tccagggatt tttttttttt tttttaaccc tcctgggccc aagtgatcct     2760

tccacctcag tctcccagct aattgagacc acaggcttgt taccaccatg ctcggctttt     2820

gcattaatct aagaaaaggg gagagaagtt aatccacatc tttactcagg caaggggcat     2880

ttcacagtgc ccaagagtgg ggttttcttg aacatacttg gtttcctatt tccccttatc     2940

tttctaaaac tgcctttctg gtggcttttt ttaaaattat tactaatgat gcttttatag     3000

ctgcttggat tctctgagaa atgatgggga gtgagtgatc actggtatta actttataca     3060

cttggatttc atttgtaact ttaggatgta aaggtatatt gtgaacccta gctgtgtcag     3120

aatctccatc cctgaaattt ctcattagtg gtactggggt gggatcttgg atggtgacat     3180

tgaaactaca ctaaatcccc tcactatgaa tgggttgtta aaggcaatgg tttgtgtcaa     3240

aactggttta ggattactta gattgtgttc ctgaagaaaa gagtccaggt aaatggtatg     3300

atcaataaag gacaggctgg tgctaacata aaatccaata ttgtaatcct agcactttgg     3360

gaggccaagg cgggtggatc acaaggtcaa gagatagaga ccatctttgc caacatggtg     3420

aaactccatc tctactgaaa atacaaaaat tagctgggcg tggtagtgca agctgaaggc     3480

tgaggcagga gaatcactcg aacccgggag gcagaggttg cagtgagccg agatcacacc     3540

actgtactcc agcccggcac tccagcctgg cgacaagagt gagactccac ctcaaaaaaa     3600

aaaaaaagaa tccaatactg cccaaggata ggtattttat agatgggcaa ctggctgaaa     3660

ggttaattct ctagggctag tagaactgga tcccaacacc aaactcttaa ttagacctag     3720

gcctcagctg cactgcccga aaagcatttg ggcagaccct gagcagaata ctggtctcag     3780

gccaagccca atacagccat taaagatgac ctacagtgct gtgtaccctg gggcaatagg     3840

gttaaatggt agttagcaac tagggctagt cttcccttac ctcaaaggct ctcactaccg     3900

tggaccacct agtctgtaac tctttctgag gagctgttac tgaatattaa aaagatagac     3960

ttcaactatg aaa                                                        3973


<210> 36
<211> 654
<212> PRT
<213> Homo sapiens

<400> 36
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210> 37
<211> 3506
<212> DNA
<213> Homo sapiens

<400> 37
ttcctcccct ggactctttc tgagctcaga gccgccgcag ccgggacagg agggcaggct       60

ttctccaacc atcatgctgc ggagcatatt acctgtacgc cctggctccg ggagcggcag      120

tcgagtatcc tctggtcagg cggcgcgggc ggcgcctcag cggaagagcg ggcctctggg      180

ccgcagtgac caacccccgc ccctcacccc acgtggttgg aggtttccag aagcgctgcc      240

gccaccgcat cgcgcagctc tttgccgtcg gagcgcttgt ttgctgcctc gtactcctcc      300

atttatccgc catgataagt gccagccgag ctgcagcagc ccgtctcgtg ggcgccgcag      360

cctcccgggg ccctacggcc gcccgccacc aggatagctg gaatggcctt agtcatgagg      420

cttttagact tgtttcaagg cgggattatg catcagaagc aatcaaggga gcagttgttg      480

gtattgattt gggtactacc aactcctgcg tggcagttat ggaaggtaaa caagcaaagg      540

tgctggagaa tgccgaaggt gccagaacca ccccttcagt tgtggccttt acagcagatg      600

gtgagcgact tgttggaatg ccggccaagc gacaggctgt caccaaccca aacaatacat      660

tttatgctac caagcgtctc attggccggc gatatgatga tcctgaagta cagaaagaca      720

ttaaaaatgt tccctttaaa attgtccgtg cctccaatgg tgatgcctgg gttgaggctc      780

atgggaaatt gtattctccg agtcagattg gagcatttgt gttgatgaag atgaaagaga      840

ctgcagaaaa ttacttgggg cacacagcaa aaaatgctgt gatcacagtc ccagcttatt      900

tcaatgactc gcagagacag gccactaaag atgctggcca gatatctgga ctgaatgtgc      960

ttcgggtgat taatgagccc acagctgctg ctcttgccta tggtctagac aaatcagaag     1020

acaaagtcat tgctgtatat gatttaggtg gtggaacttt tgatatttct atcctggaaa     1080

ttcagaaagg agtatttgag gtgaaatcca caaatgggga taccttctta ggtggggaag     1140

actttgacca ggccttgcta cggcacattg tgaaggagtt caagagagag acaggggttg     1200

atttgactaa agacaacatg gcacttcaga gggtacggga agctgctgaa aaggctaaat     1260

gtgaactctc ctcatctgtg cagactgaca tcaatttgcc ctatcttaca atggattctt     1320

ctggacccaa gcatttgaat atgaagttga cccgtgctca atttgaaggg attgtcactg     1380

atctaatcag aaggactatc gctccatgcc aaaaagctat gcaagatgca gaagtcagca     1440

agagtgacat aggagaagtg attcttgtgg gtggcatgac taggatgccc aaggttcagc     1500

agactgtaca ggatcttttt ggcagagccc caagtaaagc tgtcaatcct gatgaggctg     1560

tggccattgg agctgccatt cagggaggtg tgttggccgg cgatgtcacg gatgtgctgc     1620

tccttgatgt cactcccctg tctctgggta ttgaaactct aggaggtgtc tttaccaaac     1680

ttattaatag gaataccact attccaacca agaagagcca ggtattctct actgccgctg     1740

atggtcaaac gcaagtggaa attaaagtgt gtcagggtga aagagagatg gctggagaca     1800

acaaactcct tggacagttt actttgattg gaattccacc agcccctcgt ggagttcctc     1860

agattgaagt tacatttgac attgatgcca atgggatagt acatgtttct gctaaagata     1920

aaggcacagg acgtgagcag cagattgtaa tccagtcttc tggtggatta agcaaagatg     1980

atattgaaaa tatggttaaa aatgcagaga aatatgctga agaagaccgg cgaaagaagg     2040

aacgagttga agcagttaat atggctgaag gaatcattca cgacacagaa accaagatgg     2100

aagaattcaa ggaccaatta cctgctgatg agtgcaacaa gctgaaagaa gagatttcca     2160

aaatgaggga gctcctggct agaaaagaca gcgaaacagg agaaaatatt agacaggcag     2220

catcctctct tcagcaggca tcactgaagc tgttcgaaat ggcatacaaa aagatggcat     2280

ctgagcgaga aggctctgga agttctggca ctggggaaca aaaggaagat caaaaggagg     2340

aaaaacagta ataatagcag aaattttgaa gccagaagga caacatatga agcttaggag     2400

tgaagagact tcctgagcag aaatgggcga acttcagtct ttttactgtg tttttgcagt     2460

attctatata taatttcctt aatttgtaaa tttagtgacc attagctagt gatcatttaa     2520

tggacagtga ttctaacagt ataaagttca caatattcta tgtccctagc ctgtcatttt     2580

tcagctgcat gtaaaaggag gtaggatgaa ttgatcatta taaagattta actattttat     2640

gctgaagtga ccatattttc aaggggtgaa accatctcgc acacagcaat gaaggtagtc     2700

atccatagac ttgaaatgag accacatatg gggatgagat ccttctagtt agcctagtac     2760

tgctgtactg gcctgtatgt acatggggtc cttcaactga ggccttgcaa gtcaagctgg     2820

ctgtgccatg tttgtagatg gggcagagga atctagaaca atgggaaact tagctattta     2880

tattaggtac agctattaaa acaaggtagg aatgaggcta gacctttaac ttccctaagg     2940

catacttttc tagctacctt ctgccctgtg tctggcacct acatccttga tgattgttct     3000

cttacccatt ctggaatttt ttttttttta aataaataca gaaagcatct tgatctcttg     3060

tttgtgaggg gtgatgccct gagatttagc ttcaagaata tgccatggct catgcttccc     3120

atatttccca aagagggaaa tacaggattt gctaacactg gttaaaaatg caaattcaag     3180

atttggaagg gctgttataa tgaaataatg agcagtatca gcatgtgcaa atcttgtttg     3240

aaggatttta ttttctcccc ttagaccttt ggtacattta gaatcttgaa agtttctaga     3300

tctctaacat gaaagtttct agatctctaa catgaaagtt tttagatctc taacatgaaa     3360

accaaggtgg ctattttcag gttgctttca gctccaagta gaaataacca gaattggctt     3420

acattaaaga aactgcatct agaaataagt cctaagatac tatttctatg gctcaaaaat     3480

aaaaggaacc cagatttctt tcccta                                          3506


<210> 38
<211> 679
<212> PRT
<213> Homo sapiens

<400> 38
Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210> 39
<211> 931
<212> DNA
<213> Homo sapiens

<400> 39
tttcgtcggc ccgccccttg gcttctgcac tgatggtggg tggatgagta atgcatccag       60

gaagcctgga ggcctgtggt ttccgcaccc gctgccaccc ccgcccctag cgtggacatt      120

tatcctctag cgctcaggcc ctgccgccat cgccgcagat ccagcgccca gagagacacc      180

agagaaccca ccatggcccc ctttgagccc ctggcttctg gcatcctgtt gttgctgtgg      240

ctgatagccc ccagcagggc ctgcacctgt gtcccacccc acccacagac ggccttctgc      300

aattccgacc tcgtcatcag ggccaagttc gtggggacac cagaagtcaa ccagaccacc      360

ttataccagc gttatgagat caagatgacc aagatgtata aagggttcca agccttaggg      420

gatgccgctg acatccggtt cgtctacacc cccgccatgg agagtgtctg cggatacttc      480

cacaggtccc acaaccgcag cgaggagttt ctcattgctg gaaaactgca ggatggactc      540

ttgcacatca ctacctgcag ttttgtggct ccctggaaca gcctgagctt agctcagcgc      600

cggggcttca ccaagaccta cactgttggc tgtgaggaat gcacagtgtt tccctgttta      660

tccatcccct gcaaactgca gagtggcact cattgcttgt ggacggacca gctcctccaa      720

ggctctgaaa agggcttcca gtcccgtcac cttgcctgcc tgcctcggga gccagggctg      780

tgcacctggc agtccctgcg gtcccagata gcctgaatcc tgcccggagt ggaagctgaa      840

gcctgcacag tgtccaccct gttcccactc ccatctttct tccggacaat gaaataaaga      900

gttaccaccc agcagaaaaa aaaaaaaaaa a                                     931


<210> 40
<211> 207
<212> PRT
<213> Homo sapiens

<400> 40
Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala Cys Thr Cys Val Pro Pro His Pro Gln 
            20                  25                  30          


Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly 
        35                  40                  45              


Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys 
    50                  55                  60                  


Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 
65                  70                  75                  80  


Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 
                85                  90                  95      


His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 
            100                 105                 110         


Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 
        115                 120                 125             


Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 
    130                 135                 140                 


Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 
145                 150                 155                 160 


Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 
                165                 170                 175     


Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 
            180                 185                 190         


Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 
        195                 200                 205         


<210> 41
<211> 2664
<212> DNA
<213> Homo sapiens

<400> 41
agagccagcc cggaggagct agaaccttcc ccgcatttct ttcagcagcc tgagtcagag       60

gcgggctggc ctggcgtagc cgcccagcct cgcggctcat gccccgatct gcccgaacct      120

tctcccgggg tcagcgccgc gccgcgccac ccggctgagt cagcccgggc gggcgagagg      180

ctctcaactg ggcgggaagg tgcgggaagg tgcggaaagg ttcgcgaaag ttcgcggcgg      240

cgggggtcgg gtgaggcgca aaaggataaa aagcccgtgg aagcggagct gagcagatcc      300

gagccgggct ggctgcagag aaaccgcagg gagagcctca ctgctgagcg cccctcgacg      360

gcggagcggc agcagcctcc gtggcctcca gcatccgaca agaagcttca gccatgcagg      420

ccccacggga gctcgcggtg ggcatcgacc tgggcaccac ctactcgtgc gtgggcgtgt      480

ttcagcaggg ccgcgtggag atcctggcca acgaccaggg caaccgcacc acgcccagct      540

acgtggcctt caccgacacc gagcggctgg tcggggacgc ggccaagagc caggcggccc      600

tgaaccccca caacaccgtg ttcgatgcca agcggctgat cgggcgcaag ttcgcggaca      660

ccacggtgca gtcggacatg aagcactggc ccttccgggt ggtgagcgag ggcggcaagc      720

ccaaggtgcg cgtatgctac cgcggggagg acaagacgtt ctaccccgag gagatctcgt      780

ccatggtgct gagcaagatg aaggagacgg ccgaggcgta cctgggccag cccgtgaagc      840

acgcagtgat caccgtgccc gcctatttca atgactcgca gcgccaggcc accaaggacg      900

cgggggccat cgcggggctc aacgtgttgc ggatcatcaa tgagcccacg gcagctgcca      960

tcgcctatgg gctggaccgg cggggcgcgg gagagcgcaa cgtgctcatt tttgacctgg     1020

gtgggggcac cttcgatgtg tcggttctct ccattgacgc tggtgtcttt gaggtgaaag     1080

ccactgctgg agatacccac ctgggaggag aggacttcga caaccggctc gtgaaccact     1140

tcatggaaga attccggcgg aagcatggga aggacctgag cgggaacaag cgtgccctgc     1200

gcaggctgcg cacagcctgt gagcgcgcca agcgcaccct gtcctccagc acccaggcca     1260

ccctggagat agactccctg ttcgagggcg tggacttcta cacgtccatc actcgtgccc     1320

gctttgagga actgtgctca gacctcttcc gcagcaccct ggagccggtg gagaaggccc     1380

tgcgggatgc caagctggac aaggcccaga ttcatgacgt cgtcctggtg gggggctcca     1440

ctcgcatccc caaggtgcag aagttgctgc aggacttctt caacggcaag gagctgaaca     1500

agagcatcaa ccctgatgag gctgtggcct atggggctgc tgtgcaggcg gccgtgttga     1560

tgggggacaa atgtgagaaa gtgcaggatc tcctgctgct ggatgtggct cccctgtctc     1620

tggggctgga gacagcaggt ggggtgatga ccacgctgat ccagaggaac gccactatcc     1680

ccaccaagca gacccagact ttcaccacct actcggacaa ccagcctggg gtcttcatcc     1740

aggtgtatga gggtgagagg gccatgacca aggacaacaa cctgctgggg cgttttgaac     1800

tcagtggcat ccctcctgcc ccacgtggag tcccccagat agaggtgacc tttgacattg     1860

atgctaatgg catcctgagc gtgacagcca ctgacaggag cacaggtaag gctaacaaga     1920

tcaccatcac caatgacaag ggccggctga gcaaggagga ggtggagagg atggttcatg     1980

aagccgagca gtacaaggct gaggatgagg cccagaggga cagagtggct gccaaaaact     2040

cgctggaggc ccatgtcttc catgtgaaag gttctttgca agaggaaagc cttagggaca     2100

agattcccga agaggacagg cgcaaaatgc aagacaagtg tcgggaagtc cttgcctggc     2160

tggagcacaa ccagctggca gagaaggagg agtatgagca tcagaagagg gagctggagc     2220

aaatctgtcg ccccatcttc tccaggctct atggggggcc tggtgtccct gggggcagca     2280

gttgtggcac tcaagcccgc cagggggacc ccagcaccgg ccccatcatt gaggaggttg     2340

attgaatggc ccttcgtgat aagtcagctg tgactgtcag ggctatgcta tgggccttct     2400

agactgtctt ctatgatcct gcccttcaga gatgaacttt ccctccaaag ctagaacttt     2460

cttcccagga taactgaagt cttttgactt tttgggggga gggcggttca tcctcttctg     2520

cttcaaataa aaagtcatta atttattaaa acttgtgtgg cactttaaca ttgctttcac     2580

ctatattttg tgtactttgt tacttgcatg tatgaatttt gttatgtaaa atatagttat     2640

agacctaaat aaaaaaaaaa aaaa                                            2664


<210> 42
<211> 643
<212> PRT
<213> Homo sapiens

<400> 42
Met Gln Ala Pro Arg Glu Leu Ala Val Gly Ile Asp Leu Gly Thr Thr 
1               5                   10                  15      


Tyr Ser Cys Val Gly Val Phe Gln Gln Gly Arg Val Glu Ile Leu Ala 
            20                  25                  30          


Asn Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp 
        35                  40                  45              


Thr Glu Arg Leu Val Gly Asp Ala Ala Lys Ser Gln Ala Ala Leu Asn 
    50                  55                  60                  


Pro His Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe 
65                  70                  75                  80  


Ala Asp Thr Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Arg Val 
                85                  90                  95      


Val Ser Glu Gly Gly Lys Pro Lys Val Arg Val Cys Tyr Arg Gly Glu 
            100                 105                 110         


Asp Lys Thr Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Ser Lys 
        115                 120                 125             


Met Lys Glu Thr Ala Glu Ala Tyr Leu Gly Gln Pro Val Lys His Ala 
    130                 135                 140                 


Val Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr 
145                 150                 155                 160 


Lys Asp Ala Gly Ala Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn 
                165                 170                 175     


Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Arg Gly Ala 
            180                 185                 190         


Gly Glu Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp 
        195                 200                 205             


Val Ser Val Leu Ser Ile Asp Ala Gly Val Phe Glu Val Lys Ala Thr 
    210                 215                 220                 


Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val 
225                 230                 235                 240 


Asn His Phe Met Glu Glu Phe Arg Arg Lys His Gly Lys Asp Leu Ser 
                245                 250                 255     


Gly Asn Lys Arg Ala Leu Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala 
            260                 265                 270         


Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Thr Leu Glu Ile Asp Ser 
        275                 280                 285             


Leu Phe Glu Gly Val Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe 
    290                 295                 300                 


Glu Glu Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu 
305                 310                 315                 320 


Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Val 
                325                 330                 335     


Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu 
            340                 345                 350         


Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp 
        355                 360                 365             


Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Val Leu Met Gly 
    370                 375                 380                 


Asp Lys Cys Glu Lys Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro 
385                 390                 395                 400 


Leu Ser Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Thr Leu Ile 
                405                 410                 415     


Gln Arg Asn Ala Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr 
            420                 425                 430         


Tyr Ser Asp Asn Gln Pro Gly Val Phe Ile Gln Val Tyr Glu Gly Glu 
        435                 440                 445             


Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser 
    450                 455                 460                 


Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe 
465                 470                 475                 480 


Asp Ile Asp Ala Asn Gly Ile Leu Ser Val Thr Ala Thr Asp Arg Ser 
                485                 490                 495     


Thr Gly Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu 
            500                 505                 510         


Ser Lys Glu Glu Val Glu Arg Met Val His Glu Ala Glu Gln Tyr Lys 
        515                 520                 525             


Ala Glu Asp Glu Ala Gln Arg Asp Arg Val Ala Ala Lys Asn Ser Leu 
    530                 535                 540                 


Glu Ala His Val Phe His Val Lys Gly Ser Leu Gln Glu Glu Ser Leu 
545                 550                 555                 560 


Arg Asp Lys Ile Pro Glu Glu Asp Arg Arg Lys Met Gln Asp Lys Cys 
                565                 570                 575     


Arg Glu Val Leu Ala Trp Leu Glu His Asn Gln Leu Ala Glu Lys Glu 
            580                 585                 590         


Glu Tyr Glu His Gln Lys Arg Glu Leu Glu Gln Ile Cys Arg Pro Ile 
        595                 600                 605             


Phe Ser Arg Leu Tyr Gly Gly Pro Gly Val Pro Gly Gly Ser Ser Cys 
    610                 615                 620                 


Gly Thr Gln Ala Arg Gln Gly Asp Pro Ser Thr Gly Pro Ile Ile Glu 
625                 630                 635                 640 


Glu Val Asp 
            


<210> 43
<211> 2970
<212> DNA
<213> Homo sapiens

<400> 43
gttttaaacg cgcagccgag ggccgcgcgc aggagtaggg agggcctagg gcggcggagc       60

cgactcgtcg cggccgaggc gcgcgcggtc cgtgccggcg tcagtctggg attggccggc      120

ccgcgacttc ctccgccccc tgccaatcgc cggggacgac ttccgtgggt ttttccggct      180

cccccgcgtc gctaaggagc gacgggctgt cggccagacc ccgagttctc ggtgcgctca      240

gcggccgccg acgctaggag gccgcgctcc gcccccgcta ccatgaggcc ccggaaagcc      300

ttcctgctcc tgctgctctt ggggctggtg cagctgctgg ccgtggcggg tgccgagggc      360

ccggacgagg attcttctaa cagagaaaat gccattgagg atgaagagga ggaggaggag      420

gaagatgatg atgaggaaga agacgacttg gaagttaagg aagaaaatgg agtcttggtc      480

ctaaatgatg caaactttga taattttgtg gctgacaaag acacagtgct gctggagttt      540

tatgctccat ggtgtggaca ttgcaagcag tttgctccgg aatatgaaaa aattgccaac      600

atattaaagg ataaagatcc tcccattcct gttgccaaga tcgatgcaac ctcagcgtct      660

gtgctggcca gcaggtttga tgtgagtggc taccccacca tcaagatcct taagaagggg      720

caggctgtag actacgaggg ctccagaacc caggaagaaa ttgttgccaa ggtcagagaa      780

gtctcccagc ccgactggac gcctccacca gaagtcacgc ttgtgttgac caaagagaac      840

tttgatgaag ttgtgaatga tgcagatatc attctggtgg agttttatgc cccatggtgt      900

ggacactgca agaaacttgc ccccgagtat gagaaggccg ccaaggagct cagcaagcgt      960

tctcctccaa ttcccctggc aaaggtcgac gccaccgcag aaacagacct ggccaagagg     1020

tttgatgtct ctggctatcc caccctgaaa attttccgca aaggaaggcc ttatgactac     1080

aacggcccac gagaaaaata tggaatcgtt gattacatga tcgagcagtc cgggcctccc     1140

tccaaggaga ttctgaccct gaagcaggtc caggagttcc tgaaggatgg agacgatgtc     1200

atcatcatcg gggtctttaa gggggagagt gacccagcct accagcaata ccaggatgcc     1260

gctaacaacc tgagagaaga ttacaaattt caccacactt tcagcacaga aatagcaaag     1320

ttcttgaaag tctcccaggg gcagttggtt gtaatgcagc ctgagaaatt ccagtccaag     1380

tatgagcccc ggagccacat gatggacgtc cagggctcca cccaggactc ggccatcaag     1440

gacttcgtgc tgaagtacgc cctgcccctg gttggccacc gcaaggtgtc aaacgatgct     1500

aagcgctaca ccaggcgccc cctggtggtc gtctactaca gtgtggactt cagctttgat     1560

tacagagctg caactcagtt ttggcggagc aaagtcctag aggtggccaa ggacttccct     1620

gagtacacct ttgccattgc ggacgaagag gactatgctg gggaggtgaa ggacctgggg     1680

ctcagcgaga gtggggagga tgtcaatgcc gccatcctgg acgagagtgg gaagaagttc     1740

gccatggagc cagaggagtt tgactctgac accctccgcg agtttgtcac tgctttcaaa     1800

aaaggaaaac tgaagccagt catcaaatcc cagccagtgc ccaagaacaa caagggaccc     1860

gtcaaggtcg tggtgggaaa gacctttgac tccattgtga tggaccccaa gaaggacgtc     1920

ctcatcgagt tctacgcgcc atggtgcggg cactgcaagc agctagagcc cgtgtacaac     1980

agcctggcca agaagtacaa gggccaaaag ggcctggtca tcgccaagat ggacgccact     2040

gccaacgacg tccccagcga ccgctataag gtggagggct tccccaccat ctacttcgcc     2100

cccagtgggg acaaaaagaa cccagttaaa tttgagggtg gagacagaga tctggagcat     2160

ttgagcaagt ttatagaaga acatgccaca aaactgagca ggaccaagga agagctttga     2220

aggcctgagg tctgcggaag gtgggaggag gcagacgccc tgcgtggccc atggtcgggg     2280

cgtccacgcc gaggccggca acaaacgaca gtatctcgga ttcctttttt ttttttttta     2340

attttttata ctttggtgtt tcacttcatg ctctgaatac tgaataacca tgaatgactg     2400

aatagtttag tccagatttt tacagaggat acatctattt ttatcattat ttggggtttg     2460

aaaaattttt ttttacacct tctaatttct ttatttctca aagcagataa ttcttctgtg     2520

tgaaaatgtt ttcttttttt aatttaaggt ttaaaattcc ttttccaaat catgttgatt     2580

ttgctctttg ctttttcgtt gtctgagaaa ttgttggcgt agatttggct tctggtatgt     2640

gtttctgatt gcttcctgtt gagcacaaag tgagagctgc cactgagcag ccctgccagg     2700

ggtgctgttt caggctgggc atcgccaggc ggcctccctg caaaccaagg gctgggggca     2760

aaggggcatg atccagggtc ccccagggtg ggctcagctc cagggagagg ccacccacgt     2820

ggcagcccca cctcttgaga gcccccagtg ccggagcaga aaggaccctg gacccagagg     2880

cagatactgc ggggtggtag aaaaggtaga gtaggctgtg gcaatggaat aaaacacgat     2940

taaaaacgtt aaaaaaaaaa aaaaaaaaaa                                      2970


<210> 44
<211> 645
<212> PRT
<213> Homo sapiens

<400> 44
Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val 
1               5                   10                  15      


Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Ser Ser 
            20                  25                  30          


Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp 
        35                  40                  45              


Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val 
    50                  55                  60                  


Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp 
65                  70                  75                  80  


Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
                85                  90                  95      


Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp 
            100                 105                 110         


Pro Pro Ile Pro Val Ala Lys Ile Asp Ala Thr Ser Ala Ser Val Leu 
        115                 120                 125             


Ala Ser Arg Phe Asp Val Ser Gly Tyr Pro Thr Ile Lys Ile Leu Lys 
    130                 135                 140                 


Lys Gly Gln Ala Val Asp Tyr Glu Gly Ser Arg Thr Gln Glu Glu Ile 
145                 150                 155                 160 


Val Ala Lys Val Arg Glu Val Ser Gln Pro Asp Trp Thr Pro Pro Pro 
                165                 170                 175     


Glu Val Thr Leu Val Leu Thr Lys Glu Asn Phe Asp Glu Val Val Asn 
            180                 185                 190         


Asp Ala Asp Ile Ile Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His 
        195                 200                 205             


Cys Lys Lys Leu Ala Pro Glu Tyr Glu Lys Ala Ala Lys Glu Leu Ser 
    210                 215                 220                 


Lys Arg Ser Pro Pro Ile Pro Leu Ala Lys Val Asp Ala Thr Ala Glu 
225                 230                 235                 240 


Thr Asp Leu Ala Lys Arg Phe Asp Val Ser Gly Tyr Pro Thr Leu Lys 
                245                 250                 255     


Ile Phe Arg Lys Gly Arg Pro Tyr Asp Tyr Asn Gly Pro Arg Glu Lys 
            260                 265                 270         


Tyr Gly Ile Val Asp Tyr Met Ile Glu Gln Ser Gly Pro Pro Ser Lys 
        275                 280                 285             


Glu Ile Leu Thr Leu Lys Gln Val Gln Glu Phe Leu Lys Asp Gly Asp 
    290                 295                 300                 


Asp Val Ile Ile Ile Gly Val Phe Lys Gly Glu Ser Asp Pro Ala Tyr 
305                 310                 315                 320 


Gln Gln Tyr Gln Asp Ala Ala Asn Asn Leu Arg Glu Asp Tyr Lys Phe 
                325                 330                 335     


His His Thr Phe Ser Thr Glu Ile Ala Lys Phe Leu Lys Val Ser Gln 
            340                 345                 350         


Gly Gln Leu Val Val Met Gln Pro Glu Lys Phe Gln Ser Lys Tyr Glu 
        355                 360                 365             


Pro Arg Ser His Met Met Asp Val Gln Gly Ser Thr Gln Asp Ser Ala 
    370                 375                 380                 


Ile Lys Asp Phe Val Leu Lys Tyr Ala Leu Pro Leu Val Gly His Arg 
385                 390                 395                 400 


Lys Val Ser Asn Asp Ala Lys Arg Tyr Thr Arg Arg Pro Leu Val Val 
                405                 410                 415     


Val Tyr Tyr Ser Val Asp Phe Ser Phe Asp Tyr Arg Ala Ala Thr Gln 
            420                 425                 430         


Phe Trp Arg Ser Lys Val Leu Glu Val Ala Lys Asp Phe Pro Glu Tyr 
        435                 440                 445             


Thr Phe Ala Ile Ala Asp Glu Glu Asp Tyr Ala Gly Glu Val Lys Asp 
    450                 455                 460                 


Leu Gly Leu Ser Glu Ser Gly Glu Asp Val Asn Ala Ala Ile Leu Asp 
465                 470                 475                 480 


Glu Ser Gly Lys Lys Phe Ala Met Glu Pro Glu Glu Phe Asp Ser Asp 
                485                 490                 495     


Thr Leu Arg Glu Phe Val Thr Ala Phe Lys Lys Gly Lys Leu Lys Pro 
            500                 505                 510         


Val Ile Lys Ser Gln Pro Val Pro Lys Asn Asn Lys Gly Pro Val Lys 
        515                 520                 525             


Val Val Val Gly Lys Thr Phe Asp Ser Ile Val Met Asp Pro Lys Lys 
    530                 535                 540                 


Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
545                 550                 555                 560 


Leu Glu Pro Val Tyr Asn Ser Leu Ala Lys Lys Tyr Lys Gly Gln Lys 
                565                 570                 575     


Gly Leu Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser 
            580                 585                 590         


Asp Arg Tyr Lys Val Glu Gly Phe Pro Thr Ile Tyr Phe Ala Pro Ser 
        595                 600                 605             


Gly Asp Lys Lys Asn Pro Val Lys Phe Glu Gly Gly Asp Arg Asp Leu 
    610                 615                 620                 


Glu His Leu Ser Lys Phe Ile Glu Glu His Ala Thr Lys Leu Ser Arg 
625                 630                 635                 640 


Thr Lys Glu Glu Leu 
                645 


<210> 45
<211> 2596
<212> DNA
<213> Homo sapiens

<400> 45
gagcctcgaa gtccgccggc caatcgaagg cgggccccag cggcgcgtgc gcgccgcggc       60

cagcgcgcgc gggcgggggg gcaggcgcgc cccggaccca ggatttataa aggcgaggcc      120

gggaccggcg cgcgctctcg tcgcccccgc tgtcccggcg gcgccaaccg aagcgccccg      180

cctgatccgt gtccgacatg ctgcgccgcg ctctgctgtg cctggccgtg gccgccctgg      240

tgcgcgccga cgcccccgag gaggaggacc acgtcctggt gctgcggaaa agcaacttcg      300

cggaggcgct ggcggcccac aagtacctgc tggtggagtt ctatgcccct tggtgtggcc      360

actgcaaggc tctggcccct gagtatgcca aagccgctgg gaagctgaag gcagaaggtt      420

ccgagatcag gttggccaag gtggacgcca cggaggagtc tgacctggcc cagcagtacg      480

gcgtgcgcgg ctatcccacc atcaagttct tcaggaatgg agacacggct tcccccaagg      540

aatatacagc tggcagagag gctgatgaca tcgtgaactg gctgaagaag cgcacgggcc      600

cggctgccac caccctgcct gacggcgcag ctgcagagtc cttggtggag tccagcgagg      660

tggctgtcat cggcttcttc aaggacgtgg agtcggactc tgccaagcag tttttgcagg      720

cagcagaggc catcgatgac ataccatttg ggatcacttc caacagtgac gtgttctcca      780

aataccagct cgacaaagat ggggttgtcc tctttaagaa gtttgatgaa ggccggaaca      840

actttgaagg ggaggtcacc aaggagaacc tgctggactt tatcaaacac aaccagctgc      900

cccttgtcat cgagttcacc gagcagacag ccccgaagat ttttggaggt gaaatcaaga      960

ctcacatcct gctgttcttg cccaagagtg tgtctgacta tgacggcaaa ctgagcaact     1020

tcaaaacagc agccgagagc ttcaagggca agatcctgtt catcttcatc gacagcgacc     1080

acaccgacaa ccagcgcatc ctcgagttct ttggcctgaa gaaggaagag tgcccggccg     1140

tgcgcctcat caccctggag gaggagatga ccaagtacaa gcccgaatcg gaggagctga     1200

cggcagagag gatcacagag ttctgccacc gcttcctgga gggcaaaatc aagccccacc     1260

tgatgagcca ggagctgccg gaggactggg acaagcagcc tgtcaaggtg cttgttggga     1320

agaactttga agacgtggct tttgatgaga aaaaaaacgt ctttgtggag ttctatgccc     1380

catggtgtgg tcactgcaaa cagttggctc ccatttggga taaactggga gagacgtaca     1440

aggaccatga gaacatcgtc atcgccaaga tggactcgac tgccaacgag gtggaggccg     1500

tcaaagtgca cagcttcccc acactcaagt tctttcctgc cagtgccgac aggacggtca     1560

ttgattacaa cggggaacgc acgctggatg gttttaagaa attcctggag agcggtggcc     1620

aggatggggc aggggatgat gacgatctcg aggacctgga agaagcagag gagccagaca     1680

tggaggaaga cgatgatcag aaagctgtga aagatgaact gtaatacgca aagccagacc     1740

cgggcgctgc cgagacccct cgggggctgc acacccagca gcagcgcacg cctccgaagc     1800

ctgcggcctc gcttgaagga gggcgtcgcc ggaaacccag ggaacctctc tgaagtgaca     1860

cctcacccct acacaccgtc cgttcacccc cgtctcttcc ttctgctttt cggtttttgg     1920

aaagggatcc atctccaggc agcccaccct ggtggggctt gtttcctgaa accatgatgt     1980

actttttcat acatgagtct gtccagagtg cttgctaccg tgttcggagt ctcgctgcct     2040

ccctcccgcg ggaggtttct cctctttttg aaaattccgt ctgtgggatt tttagacatt     2100

tttcgacatc agggtatttg ttccaccttg gccaggcctc ctcggagaag cttgtccccc     2160

gtgtgggagg gacggagccg gactggacat ggtcactcag taccgcctgc agtgtcgcca     2220

tgactgatca tggctcttgc atttttgggt aaatggagac ttccggatcc tgtcagggtg     2280

tcccccatgc ctggaagagg agctggtggc tgccagccct ggggcccggc acaggcctgg     2340

gccttcccct tccctcaagc cagggctcct cctcctgtcg tgggctcatt gtgaccactg     2400

gcctctctac agcacggcct gtggcctgtt caaggcagaa ccacgaccct tgactcccgg     2460

gtggggaggt ggccaaggat gctggagctg aatcagacgc tgacagttct tcaggcattt     2520

ctatttcaca atcgaattga acacattggc caaataaagt tgaaatttta ccacctgtaa     2580

aaaaaaaaaa aaaaaa                                                     2596


<210> 46
<211> 508
<212> PRT
<213> Homo sapiens

<400> 46
Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210> 47
<211> 3822
<212> DNA
<213> Homo sapiens

<400> 47
cggcggaggc aaggcggccg cggcgcggag cagccgacgc acgctagtgg gtccgcccgc       60

caccgcccct tcctcggcgt ccgctcccgc ccttgccgtc ccccgcgcgg ctccgcgcct      120

cgggccccgg gcgcagccag ccctccagac gcccgcggtc ccggcggcgt gtgctgctct      180

tcctccgccc gcggtttcca gcgccgctcc ttcccccgct tgggcaggga gggggcattg      240

atcttcgatc gcgaagatgg ctgctggctg cctgctggcc ttgactctga cacttttcca      300

atctttgctc atcggcccct cgtcggagga gccgttccct tcggccgtca ctatcaaatc      360

atgggtggat aagatgcaag aagaccttgt cacactggca aaaacagcaa gtggagtcaa      420

tcagcttgtt gatatttatg agaaatatca agatttgtat actgtggaac caaataatgc      480

acgccagctg gtagaaattg cagccaggga tattgagaaa cttctgagca acagatctaa      540

agccctggtg cgcctggcat tggaagcgga gaaagttcaa gcagctcacc agtggagaga      600

agattttgca agcaatgaag ttgtctacta caatgcaaag gatgatctcg atcctgagaa      660

aaatgacagt gagccaggca gccagaggat aaaacctgtt ttcattgaag atgctaattt      720

tggacgacaa atatcttatc agcacgcagc agtccatatt cctactgaca tctatgaggg      780

ctcaacaatt gtgttaaatg aactcaactg gacaagtgcc ttagatgaag ttttcaaaaa      840

gaatcgcgag gaagaccctt cattattgtg gcaggttttt ggcagtgcca ctggcctagc      900

tcgatattat ccagcttcac catgggttga taatagtaga actccaaata agattgacct      960

ttatgatgta cgcagaagac catggtacat ccaaggagct gcatctccta aagacatgct     1020

tattctggtg gatgtgagtg gaagtgttag tggattgaca cttaaactga tccgaacatc     1080

tgtctccgaa atgttagaaa ccctctcaga tgatgatttc gtgaatgtag cttcatttaa     1140

cagcaatgct caggatgtaa gctgttttca gcaccttgtc caagcaaatg taagaaataa     1200

aaaagtgttg aaagacgcgg tgaataatat cacagccaaa ggaattacag attataagaa     1260

gggctttagt tttgcttttg aacagctgct taattataat gtttccagag caaactgcaa     1320

taagattatt atgctattca cggatggagg agaagagaga gcccaggaga tatttaacaa     1380

atacaataaa gataaaaaag tacgtgtatt cacgttttca gttggtcaac acaattatga     1440

cagaggacct attcagtgga tggcctgtga aaacaaaggt tattattatg aaattccttc     1500

cattggtgca ataagaatca atactcagga atatttggat gttttgggaa gaccaatggt     1560

tttagcagga gacaaagcta agcaagtcca atggacaaat gtgtacctgg atgcattgga     1620

actgggactt gtcattactg gaactcttcc ggtcttcaac ataaccggcc aatttgaaaa     1680

taagacaaac ttaaagaacc agctgattct tggtgtgatg ggagtagatg tgtctttgga     1740

agatattaaa agactgacac cacgttttac actgtgcccc aatgggtatt actttgcaat     1800

cgatcctaat ggttatgttt tattacatcc aaatcttcag ccaaagaacc ccaaatctca     1860

ggagccagta acattggatt tccttgatgc agagttagag aatgatatta aagtggagat     1920

tcgaaataag atgattgatg gggaaagtgg agaaaaaaca ttcagaactc tggttaaatc     1980

tcaagatgag agatatattg acaaaggaaa caggacatac acatggacac ctgtcaatgg     2040

cacagattac agtttggcct tggtattacc aacctacagt ttttactata taaaagccaa     2100

actagaagag acaataactc aggccagatc aaaaaagggc aaaatgaagg attcggaaac     2160

cctgaagcca gataattttg aagaatctgg ctatacattc atagcaccaa gagattactg     2220

caatgacctg aaaatatcgg ataataacac tgaatttctt ttaaatttca acgagtttat     2280

tgatagaaaa actccaaaca acccatcatg taacgcggat ttgattaata gagtcttgct     2340

tgatgcaggc tttacaaatg aacttgtcca aaattactgg agtaagcaga aaaatatcaa     2400

gggagtgaaa gcacgatttg ttgtgactga tggtgggatt accagagttt atcccaaaga     2460

ggctggagaa aattggcaag aaaacccaga gacatatgag gacagcttct ataaaaggag     2520

cctagataat gataactatg ttttcactgc tccctacttt aacaaaagtg gacctggtgc     2580

ctatgaatcg ggcattatgg taagcaaagc tgtagaaata tatattcaag ggaaacttct     2640

taaacctgca gttgttggaa ttaaaattga tgtaaattcc tggatagaga atttcaccaa     2700

aacctcaatc agagatccgt gtgctggtcc agtttgtgac tgcaaaagaa acagtgacgt     2760

aatggattgt gtgattctgg atgatggtgg gtttcttctg atggcaaatc atgatgatta     2820

tactaatcag attggaagat tttttggaga gattgatccc agcttgatga gacacctggt     2880

taatatatca gtttatgctt ttaacaaatc ttatgattat cagtcagtat gtgagcccgg     2940

tgctgcacca aaacaaggag caggacatcg ctcagcatat gtgccatcag tagcagacat     3000

attacaaatt ggctggtggg ccactgctgc tgcctggtct attctacagc agtttctctt     3060

gagtttgacc tttccacgac tccttgaggc agttgagatg gaggatgatg acttcacggc     3120

ctccctgtcc aagcagagct gcattactga acaaacccag tatttcttcg ataacgacag     3180

taaatcattc agtggtgtat tagactgtgg aaactgttcc agaatctttc atggagaaaa     3240

gcttatgaac accaacttaa tattcataat ggttgagagc aaagggacat gtccatgtga     3300

cacacgactg ctcatacaag cggagcagac ttctgacggt ccaaatcctt gtgacatggt     3360

taagcaaccc agataccgaa aagggcctga tgtctgcttt gataacaatg tcttggagga     3420

ttatactgac tgtggtggtg tttctggatt aaatccctcc ctgtggtata tcattggaat     3480

ccagtttcta ctactttggc tggtatctgg cagcacacac cgcctgttat gaccttctaa     3540

aaaccaaatc tgcatagtta aactccagac cctgccaaaa catgagccct gccctcaatt     3600

acagtaacgt agggtcagct ataaaatcag acaaacatta gctgggcctg ttccatggca     3660

taacactaag gcgcagactc ctaaggcacc cactggctgc atgtcagggt gtcagatcct     3720

taaacgtgtg tgaatgctgc atcatctatg tgtaacatca aagcaaaatc ctatacgtgt     3780

cctctattgg aaaatttggg agtttgttgt tgcattgttg gt                        3822


<210> 48
<211> 1091
<212> PRT
<213> Homo sapiens

<400> 48
Met Ala Ala Gly Cys Leu Leu Ala Leu Thr Leu Thr Leu Phe Gln Ser 
1               5                   10                  15      


Leu Leu Ile Gly Pro Ser Ser Glu Glu Pro Phe Pro Ser Ala Val Thr 
            20                  25                  30          


Ile Lys Ser Trp Val Asp Lys Met Gln Glu Asp Leu Val Thr Leu Ala 
        35                  40                  45              


Lys Thr Ala Ser Gly Val Asn Gln Leu Val Asp Ile Tyr Glu Lys Tyr 
    50                  55                  60                  


Gln Asp Leu Tyr Thr Val Glu Pro Asn Asn Ala Arg Gln Leu Val Glu 
65                  70                  75                  80  


Ile Ala Ala Arg Asp Ile Glu Lys Leu Leu Ser Asn Arg Ser Lys Ala 
                85                  90                  95      


Leu Val Arg Leu Ala Leu Glu Ala Glu Lys Val Gln Ala Ala His Gln 
            100                 105                 110         


Trp Arg Glu Asp Phe Ala Ser Asn Glu Val Val Tyr Tyr Asn Ala Lys 
        115                 120                 125             


Asp Asp Leu Asp Pro Glu Lys Asn Asp Ser Glu Pro Gly Ser Gln Arg 
    130                 135                 140                 


Ile Lys Pro Val Phe Ile Glu Asp Ala Asn Phe Gly Arg Gln Ile Ser 
145                 150                 155                 160 


Tyr Gln His Ala Ala Val His Ile Pro Thr Asp Ile Tyr Glu Gly Ser 
                165                 170                 175     


Thr Ile Val Leu Asn Glu Leu Asn Trp Thr Ser Ala Leu Asp Glu Val 
            180                 185                 190         


Phe Lys Lys Asn Arg Glu Glu Asp Pro Ser Leu Leu Trp Gln Val Phe 
        195                 200                 205             


Gly Ser Ala Thr Gly Leu Ala Arg Tyr Tyr Pro Ala Ser Pro Trp Val 
    210                 215                 220                 


Asp Asn Ser Arg Thr Pro Asn Lys Ile Asp Leu Tyr Asp Val Arg Arg 
225                 230                 235                 240 


Arg Pro Trp Tyr Ile Gln Gly Ala Ala Ser Pro Lys Asp Met Leu Ile 
                245                 250                 255     


Leu Val Asp Val Ser Gly Ser Val Ser Gly Leu Thr Leu Lys Leu Ile 
            260                 265                 270         


Arg Thr Ser Val Ser Glu Met Leu Glu Thr Leu Ser Asp Asp Asp Phe 
        275                 280                 285             


Val Asn Val Ala Ser Phe Asn Ser Asn Ala Gln Asp Val Ser Cys Phe 
    290                 295                 300                 


Gln His Leu Val Gln Ala Asn Val Arg Asn Lys Lys Val Leu Lys Asp 
305                 310                 315                 320 


Ala Val Asn Asn Ile Thr Ala Lys Gly Ile Thr Asp Tyr Lys Lys Gly 
                325                 330                 335     


Phe Ser Phe Ala Phe Glu Gln Leu Leu Asn Tyr Asn Val Ser Arg Ala 
            340                 345                 350         


Asn Cys Asn Lys Ile Ile Met Leu Phe Thr Asp Gly Gly Glu Glu Arg 
        355                 360                 365             


Ala Gln Glu Ile Phe Asn Lys Tyr Asn Lys Asp Lys Lys Val Arg Val 
    370                 375                 380                 


Phe Thr Phe Ser Val Gly Gln His Asn Tyr Asp Arg Gly Pro Ile Gln 
385                 390                 395                 400 


Trp Met Ala Cys Glu Asn Lys Gly Tyr Tyr Tyr Glu Ile Pro Ser Ile 
                405                 410                 415     


Gly Ala Ile Arg Ile Asn Thr Gln Glu Tyr Leu Asp Val Leu Gly Arg 
            420                 425                 430         


Pro Met Val Leu Ala Gly Asp Lys Ala Lys Gln Val Gln Trp Thr Asn 
        435                 440                 445             


Val Tyr Leu Asp Ala Leu Glu Leu Gly Leu Val Ile Thr Gly Thr Leu 
    450                 455                 460                 


Pro Val Phe Asn Ile Thr Gly Gln Phe Glu Asn Lys Thr Asn Leu Lys 
465                 470                 475                 480 


Asn Gln Leu Ile Leu Gly Val Met Gly Val Asp Val Ser Leu Glu Asp 
                485                 490                 495     


Ile Lys Arg Leu Thr Pro Arg Phe Thr Leu Cys Pro Asn Gly Tyr Tyr 
            500                 505                 510         


Phe Ala Ile Asp Pro Asn Gly Tyr Val Leu Leu His Pro Asn Leu Gln 
        515                 520                 525             


Pro Lys Asn Pro Lys Ser Gln Glu Pro Val Thr Leu Asp Phe Leu Asp 
    530                 535                 540                 


Ala Glu Leu Glu Asn Asp Ile Lys Val Glu Ile Arg Asn Lys Met Ile 
545                 550                 555                 560 


Asp Gly Glu Ser Gly Glu Lys Thr Phe Arg Thr Leu Val Lys Ser Gln 
                565                 570                 575     


Asp Glu Arg Tyr Ile Asp Lys Gly Asn Arg Thr Tyr Thr Trp Thr Pro 
            580                 585                 590         


Val Asn Gly Thr Asp Tyr Ser Leu Ala Leu Val Leu Pro Thr Tyr Ser 
        595                 600                 605             


Phe Tyr Tyr Ile Lys Ala Lys Leu Glu Glu Thr Ile Thr Gln Ala Arg 
    610                 615                 620                 


Ser Lys Lys Gly Lys Met Lys Asp Ser Glu Thr Leu Lys Pro Asp Asn 
625                 630                 635                 640 


Phe Glu Glu Ser Gly Tyr Thr Phe Ile Ala Pro Arg Asp Tyr Cys Asn 
                645                 650                 655     


Asp Leu Lys Ile Ser Asp Asn Asn Thr Glu Phe Leu Leu Asn Phe Asn 
            660                 665                 670         


Glu Phe Ile Asp Arg Lys Thr Pro Asn Asn Pro Ser Cys Asn Ala Asp 
        675                 680                 685             


Leu Ile Asn Arg Val Leu Leu Asp Ala Gly Phe Thr Asn Glu Leu Val 
    690                 695                 700                 


Gln Asn Tyr Trp Ser Lys Gln Lys Asn Ile Lys Gly Val Lys Ala Arg 
705                 710                 715                 720 


Phe Val Val Thr Asp Gly Gly Ile Thr Arg Val Tyr Pro Lys Glu Ala 
                725                 730                 735     


Gly Glu Asn Trp Gln Glu Asn Pro Glu Thr Tyr Glu Asp Ser Phe Tyr 
            740                 745                 750         


Lys Arg Ser Leu Asp Asn Asp Asn Tyr Val Phe Thr Ala Pro Tyr Phe 
        755                 760                 765             


Asn Lys Ser Gly Pro Gly Ala Tyr Glu Ser Gly Ile Met Val Ser Lys 
    770                 775                 780                 


Ala Val Glu Ile Tyr Ile Gln Gly Lys Leu Leu Lys Pro Ala Val Val 
785                 790                 795                 800 


Gly Ile Lys Ile Asp Val Asn Ser Trp Ile Glu Asn Phe Thr Lys Thr 
                805                 810                 815     


Ser Ile Arg Asp Pro Cys Ala Gly Pro Val Cys Asp Cys Lys Arg Asn 
            820                 825                 830         


Ser Asp Val Met Asp Cys Val Ile Leu Asp Asp Gly Gly Phe Leu Leu 
        835                 840                 845             


Met Ala Asn His Asp Asp Tyr Thr Asn Gln Ile Gly Arg Phe Phe Gly 
    850                 855                 860                 


Glu Ile Asp Pro Ser Leu Met Arg His Leu Val Asn Ile Ser Val Tyr 
865                 870                 875                 880 


Ala Phe Asn Lys Ser Tyr Asp Tyr Gln Ser Val Cys Glu Pro Gly Ala 
                885                 890                 895     


Ala Pro Lys Gln Gly Ala Gly His Arg Ser Ala Tyr Val Pro Ser Val 
            900                 905                 910         


Ala Asp Ile Leu Gln Ile Gly Trp Trp Ala Thr Ala Ala Ala Trp Ser 
        915                 920                 925             


Ile Leu Gln Gln Phe Leu Leu Ser Leu Thr Phe Pro Arg Leu Leu Glu 
    930                 935                 940                 


Ala Val Glu Met Glu Asp Asp Asp Phe Thr Ala Ser Leu Ser Lys Gln 
945                 950                 955                 960 


Ser Cys Ile Thr Glu Gln Thr Gln Tyr Phe Phe Asp Asn Asp Ser Lys 
                965                 970                 975     


Ser Phe Ser Gly Val Leu Asp Cys Gly Asn Cys Ser Arg Ile Phe His 
            980                 985                 990         


Gly Glu Lys Leu Met Asn Thr Asn  Leu Ile Phe Ile Met  Val Glu Ser 
        995                 1000                 1005             


Lys Gly  Thr Cys Pro Cys Asp  Thr Arg Leu Leu Ile  Gln Ala Glu 
    1010                 1015                 1020             


Gln Thr  Ser Asp Gly Pro Asn  Pro Cys Asp Met Val  Lys Gln Pro 
    1025                 1030                 1035             


Arg Tyr  Arg Lys Gly Pro Asp  Val Cys Phe Asp Asn  Asn Val Leu 
    1040                 1045                 1050             


Glu Asp  Tyr Thr Asp Cys Gly  Gly Val Ser Gly Leu  Asn Pro Ser 
    1055                 1060                 1065             


Leu Trp  Tyr Ile Ile Gly Ile  Gln Phe Leu Leu Leu  Trp Leu Val 
    1070                 1075                 1080             


Ser Gly  Ser Thr His Arg Leu  Leu 
    1085                 1090     


<210> 49
<211> 6406
<212> DNA
<213> Homo sapiens

<400> 49
tgcgtcatca gggtgcgcca ctgcagctgg cattggccgg gactggaagt gcgggcttct       60

gcagcagccg aagctggagc tgctagggca gcagcggctc ccctgttgta tggacattct      120

gcacccgaaa ctgatagctg agtcctgaag ttttatgtta tgaaacagaa gaactttcat      180

cccagcacat gatttgggaa ttacactttg tgacatggat gaatctgcac tgacccttgg      240

tacaatagat gtttcttatc tgccacattc atcagaatac agtgttggtc gatgtaagca      300

cacaagtgag gaatggggtg agtgtggctt tagacccacc atcttcagat ctgcaacttt      360

aaaatggaaa gaaagcctaa tgagtcggaa aaggccattt gttggaagat gttgttactc      420

ctgcactccc cagagctggg acaaattttt caaccccagt atcccgtctt tgggtttgcg      480

gaatgttatt tatatcaatg aaactcacac aagacaccgc ggatggcttg caagacgcct      540

ttcttacgtt ctttttattc aagagcgaga tgtgcataag ggcatgtttg ccaccaatgt      600

gactgaaaat gtgctgaaca gcagtagagt acaagaggca attgcagaag tggctgctga      660

attaaaccct gatggttctg cccagcagca atcaaaagcc gttaacaaag tgaaaaagaa      720

agctaaaagg attcttcaag aaatggttgc cactgtctca ccggcaatga tcagactgac      780

tgggtgggtg ctgctaaaac tgttcaacag cttcttttgg aacattcaaa ttcacaaagg      840

tcaacttgag atggttaaag ctgcaactga gacgaatttg ccgcttctgt ttctaccagt      900

tcatagatcc catattgact atctgctgct cactttcatt ctcttctgcc ataacatcaa      960

agcaccatac attgcttcag gcaataatct caacatccca atcttcagta ccttgatcca     1020

taagcttggg ggcttcttca tacgacgaag gctcgatgaa acaccagatg gacggaaaga     1080

tgttctctat agagctttgc tccatgggca tatagttgaa ttacttcgac agcagcaatt     1140

cttggagatc ttcctggaag gcacacgttc taggagtgga aaaacctctt gtgctcgggc     1200

aggacttttg tcagttgtgg tagatactct gtctaccaat gtcatcccag acatcttgat     1260

aatacctgtt ggaatctcct atgatcgcat tatcgaaggt cactacaatg gtgaacaact     1320

gggcaaacct aagaagaatg agagcctgtg gagtgtagca agaggtgtta ttagaatgtt     1380

acgaaaaaac tatggttgtg tccgagtgga ttttgcacag ccattttcct taaaggaata     1440

tttagaaagc caaagtcaga aaccggtgtc tgctctactt tccctggagc aagcgttgtt     1500

accagctata cttccttcaa gacccagtga tgctgctgat gaaggtagag acacgtccat     1560

taatgagtcc agaaatgcaa cagatgaatc cctacgaagg aggttgattg caaatctggc     1620

tgagcatatt ctattcactg ctagcaagtc ctgtgccatt atgtccacac acattgtggc     1680

ttgcctgctc ctctacagac acaggcaggg aattgatctc tccacattgg tcgaagactt     1740

ctttgtgatg aaagaggaag tcctggctcg tgattttgac ctggggttct caggaaattc     1800

agaagatgta gtaatgcatg ccatacagct gctgggaaat tgtgtcacaa tcacccacac     1860

tagcaggaac gatgagtttt ttatcacccc cagcacaact gtcccatcag tcttcgaact     1920

caacttctac agcaatgggg tacttcatgt ctttatcatg gaggccatca tagcttgcag     1980

cctttatgca gttctgaaca agaggggact ggggggtccc actagcaccc cacctaacct     2040

gatcagccag gagcagctgg tgcggaaggc ggccagcctg tgctaccttc tctccaatga     2100

aggcaccatc tcactgcctt gccagacatt ttaccaagtc tgccatgaaa cagtaggaaa     2160

gtttatccag tatggcattc ttacagtggc agagcacgat gaccaggaag atatcagtcc     2220

tagtcttgct gagcagcagt gggacaagaa gcttccagaa cctttgtctt ggagaagtga     2280

tgaagaagat gaagacagtg actttgggga ggaacagcga gattgctacc tgaaggtgag     2340

ccaatccaag gagcaccagc agtttatcac cttcttacag agactccttg ggcctttgct     2400

ggaggcctac agctctgctg ccatctttgt tcacaacttc agtggtcctg ttccagaacc     2460

tgagtatctg caaaagttgc acaaatacct aataaccaga acagaaagaa atgttgcagt     2520

atatgctgag agtgccacat attgtcttgt gaagaatgct gtgaaaatgt ttaaggatat     2580

tggggttttc aaggagacca aacaaaagag agtgtctgtt ttagaactga gcagcacttt     2640

tctacctcaa tgcaaccgac aaaaacttct agaatatatt ctgagttttg tggtgctgta     2700

ggtaacgtgt ggcactgctg gcaaatgaag gtcatgagat gagttccttg taggtaccag     2760

cttctggctc aagagttgaa ggtgccatcg cagggtcagg cctgccctgt cccgaagtga     2820

tctcctggaa gacaagtgcc ttctccctcc atggatctgt gatcttccca gctctgcatc     2880

aacacagcag cctgcagata acacttgggg ggacctcagc ctctattcgc aactcataat     2940

ccgtagacta caagatgaaa tctcaataaa ttatttttga gtttattaaa gattgacatt     3000

ttaagtacaa cttttaagga ctaattactg tgatggacac agaaatgtag ctgtgttctg     3060

gaactgaatc ttacatggta tacttagtgc tgctgggtaa tttgttggta tattatctgg     3120

ttagtggtta atgcttcctt taaaaataat tgagtcatcc attcactctt tttcagtttt     3180

atctgtcaat agtagctaca tttttaatgg gagcaccttt tatcccaaag tgctttataa     3240

attgagtgga ctgatatata tcacacccag gtatcactgt gctgtccttt gctgtcagat     3300

ttagaaatgt ttttaagagc tatgtgaaaa cagacaatat tagtttaggt cgggaactga     3360

gatattgtaa tcaaatagtt aacatcagga agttaatttg gctggcaaaa ttctagggaa     3420

acttggccag aaaactggtg ttgaaggctt ttgctcatat aaacaagtgc cattgagttt     3480

caaatgacca gcaaatatat ttagaaccct tcctgtttta tgtctgtacc tcgtccaccc     3540

ctcaggtaat acctgcctct cacaggtaca gctgtttctt ggaaatcctc caaccaaata     3600

gcagttttcc taacttgatt agcttgagct gacagactgt tagaatacag ttctctggcc     3660

acagctgatg agggctttct gtactgcaca cagattgtgt actgcacccc agtccaggtg     3720

actggtaccc actcgagttg tgccgtgcac aacctgtcca gtatatgcat gtggtggccc     3780

tactgactgg taatggttag aggcatttat ggatttttag ctttgaggaa aaaccatgac     3840

ttttaacaaa tttttatggg ttatatgcct aaacccttat gccacatagt ggtaaataat     3900

tatgaaaaat ggtctgttca taattggtag gtgccttttg tgagcaggga gcataattat     3960

tggtttatta tggtaattat ggtgattttt taaatatcat gtaatgttaa aacgttttct     4020

aacagtttac tgttgcttat ctccaagata ttatggaatt aagaattttt ccagatgagt     4080

gttacataga ttctttgaat ttagtataaa agtactgaga attaagtttg tacttccata     4140

agcttggatt ttaaacactg atagtatctc atgagtaatg tgtgttttgg gagagggagg     4200

gatgctgatt gatatttcac attgtatgaa ataccatgtt tgaaactcat agcaataatg     4260

ctatgctgtt gtgatccctc tcaagttctg catttaaaat atattttttc tttataggaa     4320

ttgatgtata ccatgaagtc attgtcagtt gtagtagctc tgatgttgaa tgagatatca     4380

tgttttagca ttccatttta ctgactaggg tagaagaaca cttttcttgg ctacatttgg     4440

aggataccca gggagtcttg ggtgttcctt atctggggaa gcaaacattt cactagtctc     4500

tttttttcat cctttaaatt gtaaattaag gattactcaa gctcaccatt attcaagatt     4560

gggactcgct tcccagtcga cactctgccc tgcctgtcat tgctgcaaag agctgctgct     4620

ttgccaacct aagcaaagaa aatacggctt ctcttgcatt attttccctt ttggttggtt     4680

tgttttctag aagtacgttc agatgctttg gggaatgcaa tgtatgattt gctagctctc     4740

tcaccactta actcactgtg aggataaata tgcatgcttt ttgtaattaa ctggtgcttt     4800

gaaaatcttt tttaagggag aaaaatctca accaaagtta tgctcatcca gacaagctga     4860

cctttgagtt aatttcagca caactcattc ttcagtgcct catgactgaa aacaaaaaac     4920

aaaaaaacga aagcatcttc acaatgaagc ttccagatag caccgttttg ctaaaagata     4980

cattctcatt gttttccaac agtgatggct tccacataag gttaaacaaa ctaggtgctt     5040

gtaaataatt tattacagtt tactctatcg catttctgta acatgaaatg catgcccttc     5100

ttcaggggaa gactgtggtc aagttaaaaa aaaaaaacaa tattaaacaa catgaaactg     5160

cagtctgttt ttgaaaatga gaatgtccta agtgattcag aagagaggag ggaagttgtg     5220

cactctgaaa atgcatgaaa aacaaaggca aaaactagtg ggaaatgtgt agaactgtta     5280

actgagatgg cttcgagtct tccttctgga atctgttaaa tttcacaaag tcatgagggt     5340

aaatggagaa aatatttctg ggattacaat gaatgtaagc ccaaattgtg gaattgccag     5400

taacctggat ggggaaaagc atttcccata gcactccatg taatatgagt gctctgtgag     5460

atgttcatca gtgttttata gaaatggtgt tgctgggaaa ccaagtttgc acctggaaac     5520

ttacaatgca ctttagcgca gtaagggctt ggcatccggt agtgaaaaac tgtctaaccc     5580

agcattgccc aaactatttt gacaccagga cctttttctc ctttgggata cttatgaacc     5640

tctcactaat gtcctgtgga gaacattttg ggaaacacta tgttagatag ttctttaagg     5700

agacaaaacg gtaatgaaca gatagcactg gggcagaata tgcatgcatt ttgtaacgtc     5760

cagtgtggcg ttgaatagat gtgtatttcc tcccctgcag aaaataagca cagaaaatta     5820

taatgtaggt gatcggagct ctttcctttg atagagagaa cagccccaat gatcctggct     5880

ttttcactga acgtatcaga atacatggat gaattggggt aaataaggtt ttaattcaga     5940

tctagaagaa agtattgtac gtttgaatgc agatttttat ccacagatag ttgtagtgtt     6000

tagacatgac aggacctatc gttgaggttt ctaagactta ctatgggctg taaacctgtt     6060

ttttaaaact attttagaaa cctgagactt gccgtctggc attttagttt aatacaaact     6120

aatgattgca tttgaaagag attcttgacc ttatttctaa acgtctagag ctctgaaatg     6180

tcttgatgga aggtattaaa ctatttgcct gttgtacaaa gaaatgttaa gactcgtgaa     6240

aagaattact ataaggtact gtgaaataac tgcgattttg tgagcaaaac atacttggaa     6300

atgctgattg atttttatgc ttgttagtgt attgcaagaa acacagaaaa tgtagttttg     6360

ttttaataaa ccaaaaattg aacatacaaa aaaaaaaaaa aaaaaa                    6406


<210> 50
<211> 828
<212> PRT
<213> Homo sapiens

<400> 50
Met Asp Glu Ser Ala Leu Thr Leu Gly Thr Ile Asp Val Ser Tyr Leu 
1               5                   10                  15      


Pro His Ser Ser Glu Tyr Ser Val Gly Arg Cys Lys His Thr Ser Glu 
            20                  25                  30          


Glu Trp Gly Glu Cys Gly Phe Arg Pro Thr Ile Phe Arg Ser Ala Thr 
        35                  40                  45              


Leu Lys Trp Lys Glu Ser Leu Met Ser Arg Lys Arg Pro Phe Val Gly 
    50                  55                  60                  


Arg Cys Cys Tyr Ser Cys Thr Pro Gln Ser Trp Asp Lys Phe Phe Asn 
65                  70                  75                  80  


Pro Ser Ile Pro Ser Leu Gly Leu Arg Asn Val Ile Tyr Ile Asn Glu 
                85                  90                  95      


Thr His Thr Arg His Arg Gly Trp Leu Ala Arg Arg Leu Ser Tyr Val 
            100                 105                 110         


Leu Phe Ile Gln Glu Arg Asp Val His Lys Gly Met Phe Ala Thr Asn 
        115                 120                 125             


Val Thr Glu Asn Val Leu Asn Ser Ser Arg Val Gln Glu Ala Ile Ala 
    130                 135                 140                 


Glu Val Ala Ala Glu Leu Asn Pro Asp Gly Ser Ala Gln Gln Gln Ser 
145                 150                 155                 160 


Lys Ala Val Asn Lys Val Lys Lys Lys Ala Lys Arg Ile Leu Gln Glu 
                165                 170                 175     


Met Val Ala Thr Val Ser Pro Ala Met Ile Arg Leu Thr Gly Trp Val 
            180                 185                 190         


Leu Leu Lys Leu Phe Asn Ser Phe Phe Trp Asn Ile Gln Ile His Lys 
        195                 200                 205             


Gly Gln Leu Glu Met Val Lys Ala Ala Thr Glu Thr Asn Leu Pro Leu 
    210                 215                 220                 


Leu Phe Leu Pro Val His Arg Ser His Ile Asp Tyr Leu Leu Leu Thr 
225                 230                 235                 240 


Phe Ile Leu Phe Cys His Asn Ile Lys Ala Pro Tyr Ile Ala Ser Gly 
                245                 250                 255     


Asn Asn Leu Asn Ile Pro Ile Phe Ser Thr Leu Ile His Lys Leu Gly 
            260                 265                 270         


Gly Phe Phe Ile Arg Arg Arg Leu Asp Glu Thr Pro Asp Gly Arg Lys 
        275                 280                 285             


Asp Val Leu Tyr Arg Ala Leu Leu His Gly His Ile Val Glu Leu Leu 
    290                 295                 300                 


Arg Gln Gln Gln Phe Leu Glu Ile Phe Leu Glu Gly Thr Arg Ser Arg 
305                 310                 315                 320 


Ser Gly Lys Thr Ser Cys Ala Arg Ala Gly Leu Leu Ser Val Val Val 
                325                 330                 335     


Asp Thr Leu Ser Thr Asn Val Ile Pro Asp Ile Leu Ile Ile Pro Val 
            340                 345                 350         


Gly Ile Ser Tyr Asp Arg Ile Ile Glu Gly His Tyr Asn Gly Glu Gln 
        355                 360                 365             


Leu Gly Lys Pro Lys Lys Asn Glu Ser Leu Trp Ser Val Ala Arg Gly 
    370                 375                 380                 


Val Ile Arg Met Leu Arg Lys Asn Tyr Gly Cys Val Arg Val Asp Phe 
385                 390                 395                 400 


Ala Gln Pro Phe Ser Leu Lys Glu Tyr Leu Glu Ser Gln Ser Gln Lys 
                405                 410                 415     


Pro Val Ser Ala Leu Leu Ser Leu Glu Gln Ala Leu Leu Pro Ala Ile 
            420                 425                 430         


Leu Pro Ser Arg Pro Ser Asp Ala Ala Asp Glu Gly Arg Asp Thr Ser 
        435                 440                 445             


Ile Asn Glu Ser Arg Asn Ala Thr Asp Glu Ser Leu Arg Arg Arg Leu 
    450                 455                 460                 


Ile Ala Asn Leu Ala Glu His Ile Leu Phe Thr Ala Ser Lys Ser Cys 
465                 470                 475                 480 


Ala Ile Met Ser Thr His Ile Val Ala Cys Leu Leu Leu Tyr Arg His 
                485                 490                 495     


Arg Gln Gly Ile Asp Leu Ser Thr Leu Val Glu Asp Phe Phe Val Met 
            500                 505                 510         


Lys Glu Glu Val Leu Ala Arg Asp Phe Asp Leu Gly Phe Ser Gly Asn 
        515                 520                 525             


Ser Glu Asp Val Val Met His Ala Ile Gln Leu Leu Gly Asn Cys Val 
    530                 535                 540                 


Thr Ile Thr His Thr Ser Arg Asn Asp Glu Phe Phe Ile Thr Pro Ser 
545                 550                 555                 560 


Thr Thr Val Pro Ser Val Phe Glu Leu Asn Phe Tyr Ser Asn Gly Val 
                565                 570                 575     


Leu His Val Phe Ile Met Glu Ala Ile Ile Ala Cys Ser Leu Tyr Ala 
            580                 585                 590         


Val Leu Asn Lys Arg Gly Leu Gly Gly Pro Thr Ser Thr Pro Pro Asn 
        595                 600                 605             


Leu Ile Ser Gln Glu Gln Leu Val Arg Lys Ala Ala Ser Leu Cys Tyr 
    610                 615                 620                 


Leu Leu Ser Asn Glu Gly Thr Ile Ser Leu Pro Cys Gln Thr Phe Tyr 
625                 630                 635                 640 


Gln Val Cys His Glu Thr Val Gly Lys Phe Ile Gln Tyr Gly Ile Leu 
                645                 650                 655     


Thr Val Ala Glu His Asp Asp Gln Glu Asp Ile Ser Pro Ser Leu Ala 
            660                 665                 670         


Glu Gln Gln Trp Asp Lys Lys Leu Pro Glu Pro Leu Ser Trp Arg Ser 
        675                 680                 685             


Asp Glu Glu Asp Glu Asp Ser Asp Phe Gly Glu Glu Gln Arg Asp Cys 
    690                 695                 700                 


Tyr Leu Lys Val Ser Gln Ser Lys Glu His Gln Gln Phe Ile Thr Phe 
705                 710                 715                 720 


Leu Gln Arg Leu Leu Gly Pro Leu Leu Glu Ala Tyr Ser Ser Ala Ala 
                725                 730                 735     


Ile Phe Val His Asn Phe Ser Gly Pro Val Pro Glu Pro Glu Tyr Leu 
            740                 745                 750         


Gln Lys Leu His Lys Tyr Leu Ile Thr Arg Thr Glu Arg Asn Val Ala 
        755                 760                 765             


Val Tyr Ala Glu Ser Ala Thr Tyr Cys Leu Val Lys Asn Ala Val Lys 
    770                 775                 780                 


Met Phe Lys Asp Ile Gly Val Phe Lys Glu Thr Lys Gln Lys Arg Val 
785                 790                 795                 800 


Ser Val Leu Glu Leu Ser Ser Thr Phe Leu Pro Gln Cys Asn Arg Gln 
                805                 810                 815     


Lys Leu Leu Glu Tyr Ile Leu Ser Phe Val Val Leu 
            820                 825             


<210> 51
<211> 1919
<212> DNA
<213> Homo sapiens

<400> 51
tttccggcgg ttgcaccggg ccggggtgcc agcgcccgcc ttcccgtttc ctcccgttcc       60

gcagcgcgcc cacggcctgt gaccccggcg accgctcccc agtgacgaga gagcggggcc      120

gggcgctgct ccggcctgac ctgcgaaggg acctcggtcc agtcccctgt tgcgccgcgc      180

cccctgtccg tccgtgcgcg ggccagtcag gggccagtgt ctcgagcggt cgaggtcgca      240

gacctagagg cgccccacag gccggcccgg ggcgctggga gcgccggccg cgggccgggt      300

ggggatgcct ctgcacgtga agtggccgtt ccccgcggtg ccgccgctca cctggaccct      360

ggccagcagc gtcgtcatgg gcttggtggg cacctacagc tgcttctgga ccaagtacat      420

gaaccacctg accgtgcaca acagggaggt gctgtacgag ctcatcgaga agcgaggccc      480

ggccacgccc ctcatcaccg tgtccaatca ccagtcctgc atggacgacc ctcatctctg      540

ggggatcctg aaactccgcc acatctggaa cctgaagttg atgcgttgga cccctgcagc      600

tgcagacatc tgcttcacca aggagctaca ctcccacttc ttcagcttgg gcaagtgtgt      660

gcctgtgtgc cgaggagcag aatttttcca agcagagaat gaggggaaag gtgttctaga      720

cacaggcagg cacatgccag gtgctggaaa aagaagagag aaaggagatg gcgtctacca      780

gaaggggatg gacttcattt tggagaagct caaccatggg gactgggtgc atatcttccc      840

agaagggaaa gtgaacatga gttccgaatt cctgcgtttc aagtggggaa tcgggcgcct      900

gattgctgag tgtcatctca accccatcat cctgcccctg tggcatgtcg gaatgaatga      960

cgtccttcct aacagtccgc cctacttccc ccgctttgga cagaaaatca ctgtgctgat     1020

cgggaagccc ttcagtgccc tgcctgtact cgagcggctc cgggcggaga acaagtcggc     1080

tgtggagatg cggaaagccc tgacggactt cattcaagag gaattccagc atctgaagac     1140

tcaggcagag cagctccaca accacctcca gcctgggaga taggccttgc ttgctgcctt     1200

ctggattctt ggcccgcaca gagctggggc tgagggatgg actgatgctt ttagctcaaa     1260

cgtggctttt agacagattt gttcatagac cctctcaagt gccctctccg agctggtagg     1320

cattccagct cctccgtgct tcctcagtta cacaaaggac ctcagctgct tctcccactt     1380

ggccaagcag ggaggaagaa gcttaggcag ggctctcttt ccttcttgcc ttcagatgtt     1440

ctctcccagg ggctggcttc aggagggagc atagaaggca ggtgagcaac cagttggcta     1500

ggggagcagg gggcccacca gagctgtgga gaggggaccc taagactcct cggcctggct     1560

cctacccacc gcccttgccg aaccaggagc tgctcactac ctcctcaggg atggccgttg     1620

gccacgtctt ccttctgcct gagcttcccc ccgaccacag gccctttcct caggcaaggt     1680

ctggcctcag gtgggccgca ggcgggaaaa gcagcccttg gccagaagtc aagcccagcc     1740

acgtggagcc tagagtgagg gcctgaggtc tggctgcttg cccccatgct ggcgccaaca     1800

acttctccat cctttctgcc tctcaacatc acttgaatcc tagggcctgg gttttcatgt     1860

ttttgaaaca gaaccataaa gcatatgtgt tggcttgttg taaaaaaaaa aaaaaaaaa      1919


<210> 52
<211> 292
<212> PRT
<213> Homo sapiens

<400> 52
Met Pro Leu His Val Lys Trp Pro Phe Pro Ala Val Pro Pro Leu Thr 
1               5                   10                  15      


Trp Thr Leu Ala Ser Ser Val Val Met Gly Leu Val Gly Thr Tyr Ser 
            20                  25                  30          


Cys Phe Trp Thr Lys Tyr Met Asn His Leu Thr Val His Asn Arg Glu 
        35                  40                  45              


Val Leu Tyr Glu Leu Ile Glu Lys Arg Gly Pro Ala Thr Pro Leu Ile 
    50                  55                  60                  


Thr Val Ser Asn His Gln Ser Cys Met Asp Asp Pro His Leu Trp Gly 
65                  70                  75                  80  


Ile Leu Lys Leu Arg His Ile Trp Asn Leu Lys Leu Met Arg Trp Thr 
                85                  90                  95      


Pro Ala Ala Ala Asp Ile Cys Phe Thr Lys Glu Leu His Ser His Phe 
            100                 105                 110         


Phe Ser Leu Gly Lys Cys Val Pro Val Cys Arg Gly Ala Glu Phe Phe 
        115                 120                 125             


Gln Ala Glu Asn Glu Gly Lys Gly Val Leu Asp Thr Gly Arg His Met 
    130                 135                 140                 


Pro Gly Ala Gly Lys Arg Arg Glu Lys Gly Asp Gly Val Tyr Gln Lys 
145                 150                 155                 160 


Gly Met Asp Phe Ile Leu Glu Lys Leu Asn His Gly Asp Trp Val His 
                165                 170                 175     


Ile Phe Pro Glu Gly Lys Val Asn Met Ser Ser Glu Phe Leu Arg Phe 
            180                 185                 190         


Lys Trp Gly Ile Gly Arg Leu Ile Ala Glu Cys His Leu Asn Pro Ile 
        195                 200                 205             


Ile Leu Pro Leu Trp His Val Gly Met Asn Asp Val Leu Pro Asn Ser 
    210                 215                 220                 


Pro Pro Tyr Phe Pro Arg Phe Gly Gln Lys Ile Thr Val Leu Ile Gly 
225                 230                 235                 240 


Lys Pro Phe Ser Ala Leu Pro Val Leu Glu Arg Leu Arg Ala Glu Asn 
                245                 250                 255     


Lys Ser Ala Val Glu Met Arg Lys Ala Leu Thr Asp Phe Ile Gln Glu 
            260                 265                 270         


Glu Phe Gln His Leu Lys Thr Gln Ala Glu Gln Leu His Asn His Leu 
        275                 280                 285             


Gln Pro Gly Arg 
    290         


<210> 53
<211> 5411
<212> DNA
<213> Homo sapiens

<400> 53
gtgtcccata gtgtttccaa acttggaaag ggcgggggag ggcgggagga tgcggagggc       60

ggaggtatgc agacaacgag tcagagtttc cccttgaaag cctcaaaagt gtccacgtcc      120

tcaaaaagaa tggaaccaat ttaagaagcc agccccgtgg ccacgtccct tcccccattc      180

gctccctcct ctgcgccccc gcaggctcct cccagctgtg gctgcccggg cccccagccc      240

cagccctccc attggtggag gcccttttgg aggcacccta gggccaggga aacttttgcc      300

gtataaatag ggcagatccg ggctttatta ttttagcacc acggcagcag gaggtttcgg      360

ctaagttgga ggtactggcc acgactgcat gcccgcgccc gccaggtgat acctccgccg      420

gtgacccagg ggctctgcga cacaaggagt ctgcatgtct aagtgctaga catgctcagc      480

tttgtggata cgcggacttt gttgctgctt gcagtaacct tatgcctagc aacatgccaa      540

tctttacaag aggaaactgt aagaaagggc ccagccggag atagaggacc acgtggagaa      600

aggggtccac caggcccccc aggcagagat ggtgaagatg gtcccacagg ccctcctggt      660

ccacctggtc ctcctggccc ccctggtctc ggtgggaact ttgctgctca gtatgatgga      720

aaaggagttg gacttggccc tggaccaatg ggcttaatgg gacctagagg cccacctggt      780

gcagctggag ccccaggccc tcaaggtttc caaggacctg ctggtgagcc tggtgaacct      840

ggtcaaactg gtcctgcagg tgctcgtggt ccagctggcc ctcctggcaa ggctggtgaa      900

gatggtcacc ctggaaaacc cggacgacct ggtgagagag gagttgttgg accacagggt      960

gctcgtggtt tccctggaac tcctggactt cctggcttca aaggcattag gggacacaat     1020

ggtctggatg gattgaaggg acagcccggt gctcctggtg tgaagggtga acctggtgcc     1080

cctggtgaaa atggaactcc aggtcaaaca ggagcccgtg ggcttcctgg tgagagagga     1140

cgtgttggtg cccctggccc agctggtgcc cgtggcagtg atggaagtgt gggtcccgtg     1200

ggtcctgctg gtcccattgg gtctgctggc cctccaggct tcccaggtgc ccctggcccc     1260

aagggtgaaa ttggagctgt tggtaacgct ggtcctgctg gtcccgccgg tccccgtggt     1320

gaagtgggtc ttccaggcct ctccggcccc gttggacctc ctggtaatcc tggagcaaac     1380

ggccttactg gtgccaaggg tgctgctggc cttcccggcg ttgctggggc tcccggcctc     1440

cctggacccc gcggtattcc tggccctgtt ggtgctgccg gtgctactgg tgccagagga     1500

cttgttggtg agcctggtcc agctggctcc aaaggagaga gcggtaacaa gggtgagccc     1560

ggctctgctg ggccccaagg tcctcctggt cccagtggtg aagaaggaaa gagaggccct     1620

aatggggaag ctggatctgc cggccctcca ggacctcctg ggctgagagg tagtcctggt     1680

tctcgtggtc ttcctggagc tgatggcaga gctggcgtca tgggccctcc tggtagtcgt     1740

ggtgcaagtg gccctgctgg agtccgagga cctaatggag atgctggtcg ccctggggag     1800

cctggtctca tgggacccag aggtcttcct ggttcccctg gaaatatcgg ccccgctgga     1860

aaagaaggtc ctgtcggcct ccctggcatc gacggcaggc ctggcccaat tggcccagct     1920

ggagcaagag gagagcctgg caacattgga ttccctggac ccaaaggccc cactggtgat     1980

cctggcaaaa acggtgataa aggtcatgct ggtcttgctg gtgctcgggg tgctccaggt     2040

cctgatggaa acaatggtgc tcagggacct cctggaccac agggtgttca aggtggaaaa     2100

ggtgaacagg gtccccctgg tcctccaggc ttccagggtc tgcctggccc ctcaggtccc     2160

gctggtgaag ttggcaaacc aggagaaagg ggtctccatg gtgagtttgg tctccctggt     2220

cctgctggtc caagagggga acgcggtccc ccaggtgaga gtggtgctgc cggtcctact     2280

ggtcctattg gaagccgagg tccttctgga cccccagggc ctgatggaaa caagggtgaa     2340

cctggtgtgg ttggtgctgt gggcactgct ggtccatctg gtcctagtgg actcccagga     2400

gagaggggtg ctgctggcat acctggaggc aagggagaaa agggtgaacc tggtctcaga     2460

ggtgaaattg gtaaccctgg cagagatggt gctcgtggtg ctcctggtgc tgtaggtgcc     2520

cctggtcctg ctggagccac aggtgaccgg ggcgaagctg gggctgctgg tcctgctggt     2580

cctgctggtc ctcggggaag ccctggtgaa cgtggtgagg tcggtcctgc tggccccaat     2640

ggatttgctg gtcctgctgg tgctgctggt caacctggtg ctaaaggaga aagaggagcc     2700

aaagggccta agggtgaaaa cggtgttgtt ggtcccacag gccccgttgg agctgctggc     2760

ccagctggtc caaatggtcc ccccggtcct gctggaagtc gtggtgatgg aggcccccct     2820

ggtatgactg gtttccctgg tgctgctgga cggactggtc ccccaggacc ctctggtatt     2880

tctggccctc ctggtccccc tggtcctgct gggaaagaag ggcttcgtgg tcctcgtggt     2940

gaccaaggtc cagttggccg aactggagaa gtaggtgcag ttggtccccc tggcttcgct     3000

ggtgagaagg gtccctctgg agaggctggt actgctggac ctcctggcac tccaggtcct     3060

cagggtcttc ttggtgctcc tggtattctg ggtctccctg gctcgagagg tgaacgtggt     3120

ctaccaggtg ttgctggtgc tgtgggtgaa cctggtcctc ttggcattgc cggccctcct     3180

ggggcccgtg gtcctcctgg tgctgtgggt agtcctggag tcaacggtgc tcctggtgaa     3240

gctggtcgtg atggcaaccc tgggaacgat ggtcccccag gtcgcgatgg tcaacccgga     3300

cacaagggag agcgcggtta ccctggcaat attggtcccg ttggtgctgc aggtgcacct     3360

ggtcctcatg gccccgtggg tcctgctggc aaacatggaa accgtggtga aactggtcct     3420

tctggtcctg ttggtcctgc tggtgctgtt ggcccaagag gtcctagtgg cccacaaggc     3480

attcgtggcg ataagggaga gcccggtgaa aaggggccca gaggtcttcc tggcttaaag     3540

ggacacaatg gattgcaagg tctgcctggt atcgctggtc accatggtga tcaaggtgct     3600

cctggctccg tgggtcctgc tggtcctagg ggccctgctg gtccttctgg ccctgctgga     3660

aaagatggtc gcactggaca tcctggtaca gttggacctg ctggcattcg aggccctcag     3720

ggtcaccaag gccctgctgg cccccctggt ccccctggcc ctcctggacc tccaggtgta     3780

agcggtggtg gttatgactt tggttacgat ggagacttct acagggctga ccagcctcgc     3840

tcagcacctt ctctcagacc caaggactat gaagttgatg ctactctgaa gtctctcaac     3900

aaccagattg agacccttct tactcctgaa ggctctagaa agaacccagc tcgcacatgc     3960

cgtgacttga gactcagcca cccagagtgg agcagtggtt actactggat tgaccctaac     4020

caaggatgca ctatggatgc tatcaaagta tactgtgatt tctctactgg cgaaacctgt     4080

atccgggccc aacctgaaaa catcccagcc aagaactggt ataggagctc caaggacaag     4140

aaacacgtct ggctaggaga aactatcaat gctggcagcc agtttgaata taatgtagaa     4200

ggagtgactt ccaaggaaat ggctacccaa cttgccttca tgcgcctgct ggccaactat     4260

gcctctcaga acatcaccta ccactgcaag aacagcattg catacatgga tgaggagact     4320

ggcaacctga aaaaggctgt cattctacag ggctctaatg atgttgaact tgttgctgag     4380

ggcaacagca ggttcactta cactgttctt gtagatggct gctctaaaaa gacaaatgaa     4440

tggggaaaga caatcattga atacaaaaca aataagccat cacgcctgcc cttccttgat     4500

attgcacctt tggacatcgg tggtgctgac caggaattct ttgtggacat tggcccagtc     4560

tgtttcaaat aaatgaactc aatctaaatt aaaaaagaaa gaaatttgaa aaaactttct     4620

ctttgccatt tcttcttctt cttttttaac tgaaagctga atccttccat ttcttctgca     4680

catctacttg cttaaattgt gggcaaaaga gaaaaagaag gattgatcag agcattgtgc     4740

aatacagttt cattaactcc ttcccccgct cccccaaaaa tttgaatttt tttttcaaca     4800

ctcttacacc tgttatggaa aatgtcaacc tttgtaagaa aaccaaaata aaaattgaaa     4860

aataaaaacc ataaacattt gcaccacttg tggcttttga atatcttcca cagagggaag     4920

tttaaaaccc aaacttccaa aggtttaaac tacctcaaaa cactttccca tgagtgtgat     4980

ccacattgtt aggtgctgac ctagacagag atgaactgag gtccttgttt tgttttgttc     5040

ataatacaaa ggtgctaatt aatagtattt cagatacttg aagaatgttg atggtgctag     5100

aagaatttga gaagaaatac tcctgtattg agttgtatcg tgtggtgtat tttttaaaaa     5160

atttgattta gcattcatat tttccatctt attcccaatt aaaagtatgc agattatttg     5220

cccaaatctt cttcagattc agcatttgtt ctttgccagt ctcattttca tcttcttcca     5280

tggttccaca gaagctttgt ttcttgggca agcagaaaaa ttaaattgta cctattttgt     5340

atatgtgaga tgtttaaata aattgtgaaa aaaatgaaat aaagcatgtt tggttttcca     5400

aaagaacata t                                                          5411


<210> 54
<211> 1366
<212> PRT
<213> Homo sapiens

<400> 54
Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210> 55
<211> 7888
<212> DNA
<213> Homo sapiens

<400> 55
gtgcaggctg ctcccggggt aggtgaggga agcgcggagg cggcgcgcgg gggcagtggt       60

cggcgagcag cgcggtcctc gctaggggcg cccacccgtc agtctctccg gcgcgagccg      120

ccgccaccgc ccgcgccgga gtcaggcccc tgggccccca ggctcaagca gcgaagcggc      180

ctccggggga cgccgctagg cgagaggaac gcgccggtgc ccttgccttc gccgtgaccc      240

agcgtgcggg cggcgggatg agagggagcc atcgggccgc gccggccctg cggccccggg      300

ggcggctctg gcccgtgctg gccgtgctgg cggcggccgc cgcggcgggc tgtgcccagg      360

cagccatgga cgagtgcacg gacgagggcg ggcggccgca gcgctgcatg cccgagttcg      420

tcaacgccgc cttcaacgtg actgtggtgg ccaccaacac gtgtgggact ccgcccgagg      480

aatactgtgt gcagaccggg gtgaccgggg tcaccaagtc ctgtcacctg tgcgacgccg      540

ggcagcccca cctgcagcac ggggcagcct tcctgaccga ctacaacaac caggccgaca      600

ccacctggtg gcaaagccag accatgctgg ccggggtgca gtaccccagc tccatcaacc      660

tcacgctgca cctgggaaaa gcttttgaca tcacctatgt gcgtctcaag ttccacacca      720

gccgcccgga gagctttgcc atttacaagc gcacacggga agacgggccc tggattcctt      780

accagtacta cagtggttcc tgtgagaaca cctactccaa ggcaaaccgc ggcttcatca      840

ggacaggagg ggacgagcag caggccttgt gtactgatga attcagtgac atttctcccc      900

tcactggggg caacgtggcc ttttctaccc tggaaggaag gcccagcgcc tataactttg      960

acaatagccc tgtgctgcag gaatgggtaa ctgccactga catcagagta actcttaatc     1020

gcctgaacac ttttggagat gaagtgttta acgatcccaa agttctcaag tcctattatt     1080

atgccatctc tgattttgct gtaggtggca gatgtaaatg taatggacac gcaagcgagt     1140

gtatgaagaa cgaatttgat aagctggtgt gtaattgcaa acataacaca tatggagtag     1200

actgtgaaaa gtgtcttcct ttcttcaatg accggccgtg gaggagggca actgcggaaa     1260

gtgccagtga atgcctgccc tgtgattgca atggtcgatc ccaggaatgc tacttcgacc     1320

ctgaactcta tcgttccact ggccatgggg gccactgtac caactgccag gataacacag     1380

atggcgccca ctgtgagagg tgccgagaga acttcttccg ccttggcaac aatgaagcct     1440

gctcttcatg ccactgtagt cctgtgggct ctctaagcac acagtgtgat agttacggca     1500

gatgcagctg taagccagga gtgatggggg acaaatgtga ccgttgccag cctggattcc     1560

attctctcac tgaagcagga tgcaggccat gctcttgtga tccctctggc agcatagatg     1620

aatgtaatat tgaaacagga agatgtgttt gcaaagacaa tgtcgaaggc ttcaattgtg     1680

aaagatgcaa acctggattt tttaatctgg aatcatctaa tcctcggggt tgcacaccct     1740

gcttctgctt tgggcattct tctgtctgta caaacgctgt tggctacagt gtttattcta     1800

tctcctctac ctttcagatt gatgaggatg ggtggcgtgc ggaacagaga gatggctctg     1860

aagcatctct cgagtggtcc tctgagaggc aagatatcgc cgtgatctca gacagctact     1920

ttcctcggta cttcattgct cctgcaaagt tcttgggcaa gcaggtgttg agttatggtc     1980

agaacctctc cttctccttt cgagtggaca ggcgagatac tcgcctctct gcagaagacc     2040

ttgtgcttga gggagctggc ttaagagtat ctgtaccctt gatcgctcag ggcaattcct     2100

atccaagtga gaccactgtg aagtatgtct tcaggctcca tgaagcaaca gattaccctt     2160

ggaggcctgc tcttacccct tttgaatttc agaagctcct aaacaacttg acctctatca     2220

agatacgtgg gacatacagt gagagaagtg ctggatattt ggatgatgtc accctggcaa     2280

gtgctcgtcc tgggcctgga gtccctgcaa cttgggtgga gtcctgcacc tgtcctgtgg     2340

gatatggagg gcagttttgt gagatgtgcc tctcaggtta cagaagagaa actcctaatc     2400

ttggaccata cagtccatgt gtgctttgcg cctgcaatgg acacagcgag acctgtgatc     2460

ctgagacagg tgtttgtaac tgcagagaca atacggctgg cccgcactgt gagaagtgca     2520

gtgatgggta ctatggagat tcaactgcag gcacctcctc cgattgccaa ccctgtccgt     2580

gtcctggagg ttcaagttgt gctgttgttc ccaagacaaa ggaggtggtg tgcaccaact     2640

gtcctactgg caccactggt aagagatgtg agctctgtga tgatggctac tttggagacc     2700

ccctgggtag aaacggccct gtgagacttt gccgcctgtg ccagtgcagt gacaacatcg     2760

atcccaatgc agttggaaat tgcaatcgct tgacgggaga atgcctgaag tgcatctata     2820

acactgctgg cttctattgt gaccggtgca aagacggatt ttttggaaat cccctggctc     2880

ccaatccagc agacaaatgc aaagcctgca attgcaatct gtatgggacc atgaagcagc     2940

agagcagctg taaccccgtg acggggcagt gtgaatgttt gcctcacgtg actggccagg     3000

actgtggtgc ttgtgaccct ggattctaca atctgcagag tgggcaaggc tgtgagaggt     3060

gtgactgcca tgccttgggc tccaccaatg ggcagtgtga catccgcacc ggccagtgtg     3120

agtgccagcc cggcatcact ggtcagcact gtgagcgctg tgaggtcaac cactttgggt     3180

ttggacctga aggctgcaaa ccctgtgact gtcatcctga gggatctctt tcacttcagt     3240

gcaaagatga tggtcgctgt gaatgcagag aaggctttgt gggaaatcgc tgtgaccagt     3300

gtgaagaaaa ctatttctac aatcggtctt ggcctggctg ccaggaatgt ccagcttgtt     3360

accggctggt aaaggataag gttgctgatc atagagtgaa gctccaggaa ttagagagtc     3420

tcatagcaaa ccttggaact ggggatgaga tggtgacaga tcaagccttc gaggatagac     3480

taaaggaagc agagagggaa gttatggacc tccttcgtga ggcccaggat gtcaaagatg     3540

ttgaccagaa tttgatggat cgcctacaga gagtgaataa cactctgtcc agccaaatta     3600

gccgtttaca gaatatccgg aataccattg aagagactgg aaacttggct gaacaagcgc     3660

gtgcccatgt agagaacaca gagcggttga ttgaaatcgc atccagagaa cttgagaaag     3720

caaaagtcgc tgctgccaat gtgtcagtca ctcagccaga atctacaggg gacccaaaca     3780

acatgactct tttggcagaa gaggctcgaa agcttgctga acgtcataaa caggaagctg     3840

atgacattgt tcgagtggca aagacagcca atgatacgtc aactgaggca tacaacctgc     3900

ttctgaggac actggcagga gaaaatcaaa cagcatttga gattgaagag cttaatagga     3960

agtatgaaca agcgaagaac atctcacagg atctggaaaa acaagctgcc cgagtacatg     4020

aggaggccaa aagggccggt gacaaagctg tggagatcta tgccagcgtg gctcagctga     4080

gccctttgga ctctgagaca ctggagaatg aagcaaataa cataaagatg gaagctgaga     4140

atctggaaca actgattgac cagaaattaa aagattatga ggacctcaga gaagatatga     4200

gagggaagga acttgaagtc aagaaccttc tggagaaagg caagactgaa cagcagaccg     4260

cagaccaact cctagcccga gctgatgctg ccaaggccct cgctgaagaa gctgcaaaga     4320

agggacggga taccttacaa gaagctaatg acattctcaa caacctgaaa gattttgata     4380

ggcgtgtgaa cgataacaag acggccgcag aggaggcact aaggaagatt cctgccatca     4440

accagaccat cactgaagcc aatgaaaaga ccagagaagc ccagcaggcc ctgggcagtg     4500

ctgcggcgga tgccacagag gccaagaaca aggcccatga ggcggagagg atcgcgagcg     4560

ctgtccaaaa gaatgccacc agcaccaagg cagaagctga aagaactttt gcagaagtta     4620

cagatctgga taatgaggtg aacaatatgt tgaagcaact gcaggaagca gaaaaagagc     4680

taaagagaaa acaagatgac gctgaccagg acatgatgat ggcagggatg gcttcacagg     4740

ctgctcaaga agccgagatc aatgccagaa aagccaaaaa ctctgttact agcctcctca     4800

gcattattaa tgacctcttg gagcagctgg ggcagctgga tacagtggac ctgaataagc     4860

taaacgagat tgaaggcacc ctaaacaaag ccaaagatga aatgaaggtc agcgatcttg     4920

ataggaaagt gtctgacctg gagaatgaag ccaagaagca ggaggctgcc atcatggact     4980

ataaccgaga tatcgaggag atcatgaagg acattcgcaa tctggaggac atcaggaaga     5040

ccttaccatc tggctgcttc aacaccccgt ccattgaaaa gccctagtgt ctttagggct     5100

ggaaggcagc atccctctga caggggggca gttgtgaggc cacagagtgc cttgacacaa     5160

agattacatt tttcagaccc ccactcctct gctgctgtcc atgactgtcc ttttgaacca     5220

ggaaaagtca cagagtttaa agagaagcaa attaaacatc ctgaatcggg aacaaagggt     5280

tttatctaat aaagtgtctc ttccattcac gttgctacct tacccacact ttcccttctg     5340

atttgcgtga ggacgtggca tcctacgtta ctgtacagtg gcataagcac atcgtgtgag     5400

cccatgtatg ctggggtaga gcaagtagcc ctcccctgtc tcatcgatac cagcagaacc     5460

tcctcagtct cagtactctt gtttctatga aggaaaagtt tggctactaa cagtagcatt     5520

gtgatggcca gtatatccag tccatggata aagaaaatgc atctgcatct cctacccctc     5580

ttccttctaa gcaaaaggaa ataaacatcc tgtgccaaag gtattggtca tttagaatgt     5640

cggtagccat ccatcagtgc ttttagttat tatgagtgta ggacactgag ccatccgtgg     5700

gtcaggatgc aattatttat aaaagtctcc aggtgaacat ggctgaagat ttttctagta     5760

tattaataat tgactaggaa gatgaacttt ttttcagatc tttgggcagc tgataattta     5820

aatctggatg ggcagcttgc actcaccaat agaccaaaag acatcttttg atattcttat     5880

aaatggaact tacacagaag aaatagggat atgataacca ctaaaatttt gttttcaaaa     5940

tcaaactaat tcttacagct tttttattag ttagtcttgg aactagtgtt aagtatctgg     6000

cagagaacag ttaatcccta aggtcttgac aaaacagaag aaaaacaagc ctcctcgtcc     6060

tagtcttttc tagcaaaggg ataaaactta gatggcagct tgtactgtca gaatcccgtg     6120

tatccatttg ttcttctgtt ggagagatga gacatttgac ccttagctcc agttttcttc     6180

tgatgtttcc atcttccaga atccctcaaa aaacattgtt tgccaaatcc tggtggcaaa     6240

tacttgcact cagtatttca cacagctgcc aacgctatcg agttcctgca ctttgtgatt     6300

taaatccact ctaaaccttc cctctaagtg tagagggaag acccttacgt ggagtttcct     6360

agtgggcttc tcaacttttg atcctcagct ctgtggtttt aagaccacag tgtgacagtt     6420

ccctgccaca cacccccttc ctcctaccaa cccacctttg agattcatat atagccttta     6480

acactatgca actttgtact ttgcgtagca ggggcggggt ggggggaaag aaactattat     6540

ctgacacact ggtgctatta attatttcaa atttatattt ttgtgtgaat gttttgtgtt     6600

ttgtttatca tgattataga ataaggaatt tatgtaaata tacttagtcc tatttctaga     6660

atgacactct gttcactttg ctcaattttt cctcttcact ggcacaatgt atctgaatac     6720

ctccttccct cccttctaga attctttgga ttgtactcca aagaattgtg ccttgtgttt     6780

gcagcatctc cattctctaa aattaatata attgctttcc tccacaccca gccactgtaa     6840

agaggtaact tgggtcctct tccattgcag tcctgatgat cctaacctgc agcacggtgg     6900

ttttacaatg ttccagagca ggaacgccag gttgacaagc tatggtagga ttaggaaagt     6960

ttgctgaaga ggatctttga cgccacagtg ggactagcca ggaatgaggg agaaatgccc     7020

tttctggcaa ttgttggagc tggataggta agttttataa gggagtacat tttgactgag     7080

cacttagggc atcaggaaca gtgctactta ctgatgggta gactgggaga ggtggtgtaa     7140

cttagttctt gatgatccca cttcctgttt ccatctgctt gggatatacc agagtttacc     7200

acaagtgttt tgacgatata ctcctgagct ttcactctgc tgcttctccc aggcctcttc     7260

tactatggca ggagatgtgg cgtgctgttg caaagttttc acgtcattgt ttcctggcta     7320

gttcatttca ttaagtggct acatcctaac atatgcattt ggtcaaggtt gcagaagagg     7380

actgaagatt gactgccaag ctagtttggg tgaagttcac tccagcaagt ctcaggccac     7440

aatggggtgg tttggtttgg tttcctttta actttctttt tgttatttgc ttttctcctc     7500

cacctgtgtg gtatattttt taagcagaat tttatttttt aaaataaaag gttctttaca     7560

agatgatacc ttaattacac tcccgcaaca cagccattat tttattgtct agctccagtt     7620

atctgtattt tatgtaatgt aattgacagg atggctgctg cagaatgctg gttgacacag     7680

ggattattat actgctattt ttccctgaat ttttttcctt tgaattccaa ctgtggacct     7740

tttatatgtg ccttcacttt agctgtttgc cttaatctct acagccttgc tctccggggt     7800

ggttaataaa atgcaacact tggcattttt atgttttaag aaaaacagta ttttatttat     7860

aataaaatct gaatatttgt aacccttt                                        7888


<210> 56
<211> 1609
<212> PRT
<213> Homo sapiens

<400> 56
Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Glu Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu 
                245                 250                 255     


Asn Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser 
            260                 265                 270         


Tyr Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys 
        275                 280                 285             


Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe Asp Lys Leu Val 
    290                 295                 300                 


Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu 
305                 310                 315                 320 


Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala 
                325                 330                 335     


Ser Glu Cys Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr 
            340                 345                 350         


Phe Asp Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr 
        355                 360                 365             


Asn Cys Gln Asp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu 
    370                 375                 380                 


Asn Phe Phe Arg Leu Gly Asn Asn Glu Ala Cys Ser Ser Cys His Cys 
385                 390                 395                 400 


Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys 
                405                 410                 415     


Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro 
            420                 425                 430         


Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp 
        435                 440                 445             


Pro Ser Gly Ser Ile Asp Glu Cys Asn Ile Glu Thr Gly Arg Cys Val 
    450                 455                 460                 


Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly 
465                 470                 475                 480 


Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly Cys Thr Pro Cys Phe 
                485                 490                 495     


Cys Phe Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val 
            500                 505                 510         


Tyr Ser Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Ala 
        515                 520                 525             


Glu Gln Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Glu Arg 
    530                 535                 540                 


Gln Asp Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile 
545                 550                 555                 560 


Ala Pro Ala Lys Phe Leu Gly Lys Gln Val Leu Ser Tyr Gly Gln Asn 
                565                 570                 575     


Leu Ser Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala 
            580                 585                 590         


Glu Asp Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu 
        595                 600                 605             


Ile Ala Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Val 
    610                 615                 620                 


Phe Arg Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Thr 
625                 630                 635                 640 


Pro Phe Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile 
                645                 650                 655     


Arg Gly Thr Tyr Ser Glu Arg Ser Ala Gly Tyr Leu Asp Asp Val Thr 
            660                 665                 670         


Leu Ala Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu 
        675                 680                 685             


Ser Cys Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Met Cys 
    690                 695                 700                 


Leu Ser Gly Tyr Arg Arg Glu Thr Pro Asn Leu Gly Pro Tyr Ser Pro 
705                 710                 715                 720 


Cys Val Leu Cys Ala Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu 
                725                 730                 735     


Thr Gly Val Cys Asn Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu 
            740                 745                 750         


Lys Cys Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Ala Gly Thr Ser Ser 
        755                 760                 765             


Asp Cys Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Val Val 
    770                 775                 780                 


Pro Lys Thr Lys Glu Val Val Cys Thr Asn Cys Pro Thr Gly Thr Thr 
785                 790                 795                 800 


Gly Lys Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu 
                805                 810                 815     


Gly Arg Asn Gly Pro Val Arg Leu Cys Arg Leu Cys Gln Cys Ser Asp 
            820                 825                 830         


Asn Ile Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu 
        835                 840                 845             


Cys Leu Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys 
    850                 855                 860                 


Lys Asp Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys 
865                 870                 875                 880 


Cys Lys Ala Cys Asn Cys Asn Leu Tyr Gly Thr Met Lys Gln Gln Ser 
                885                 890                 895     


Ser Cys Asn Pro Val Thr Gly Gln Cys Glu Cys Leu Pro His Val Thr 
            900                 905                 910         


Gly Gln Asp Cys Gly Ala Cys Asp Pro Gly Phe Tyr Asn Leu Gln Ser 
        915                 920                 925             


Gly Gln Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn 
    930                 935                 940                 


Gly Gln Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile 
945                 950                 955                 960 


Thr Gly Gln His Cys Glu Arg Cys Glu Val Asn His Phe Gly Phe Gly 
                965                 970                 975     


Pro Glu Gly Cys Lys Pro Cys Asp Cys His Pro Glu Gly Ser Leu Ser 
            980                 985                 990         


Leu Gln Cys Lys Asp Asp Gly Arg  Cys Glu Cys Arg Glu  Gly Phe Val 
        995                 1000                 1005             


Gly Asn  Arg Cys Asp Gln Cys  Glu Glu Asn Tyr Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Ser Trp  Pro Gly Cys Gln Glu  Cys Pro Ala Cys Tyr  Arg Leu Val 
    1025                 1030                 1035             


Lys Asp  Lys Val Ala Asp His  Arg Val Lys Leu Gln  Glu Leu Glu 
    1040                 1045                 1050             


Ser Leu  Ile Ala Asn Leu Gly  Thr Gly Asp Glu Met  Val Thr Asp 
    1055                 1060                 1065             


Gln Ala  Phe Glu Asp Arg Leu  Lys Glu Ala Glu Arg  Glu Val Met 
    1070                 1075                 1080             


Asp Leu  Leu Arg Glu Ala Gln  Asp Val Lys Asp Val  Asp Gln Asn 
    1085                 1090                 1095             


Leu Met  Asp Arg Leu Gln Arg  Val Asn Asn Thr Leu  Ser Ser Gln 
    1100                 1105                 1110             


Ile Ser  Arg Leu Gln Asn Ile  Arg Asn Thr Ile Glu  Glu Thr Gly 
    1115                 1120                 1125             


Asn Leu  Ala Glu Gln Ala Arg  Ala His Val Glu Asn  Thr Glu Arg 
    1130                 1135                 1140             


Leu Ile  Glu Ile Ala Ser Arg  Glu Leu Glu Lys Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ala  Asn Val Ser Val Thr  Gln Pro Glu Ser Thr  Gly Asp Pro 
    1160                 1165                 1170             


Asn Asn  Met Thr Leu Leu Ala  Glu Glu Ala Arg Lys  Leu Ala Glu 
    1175                 1180                 1185             


Arg His  Lys Gln Glu Ala Asp  Asp Ile Val Arg Val  Ala Lys Thr 
    1190                 1195                 1200             


Ala Asn  Asp Thr Ser Thr Glu  Ala Tyr Asn Leu Leu  Leu Arg Thr 
    1205                 1210                 1215             


Leu Ala  Gly Glu Asn Gln Thr  Ala Phe Glu Ile Glu  Glu Leu Asn 
    1220                 1225                 1230             


Arg Lys  Tyr Glu Gln Ala Lys  Asn Ile Ser Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Gln Ala  Ala Arg Val His Glu  Glu Ala Lys Arg Ala  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Glu Ile Tyr Ala Ser  Val Ala Gln Leu Ser  Pro Leu Asp 
    1265                 1270                 1275             


Ser Glu  Thr Leu Glu Asn Glu  Ala Asn Asn Ile Lys  Met Glu Ala 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gln Leu Ile  Asp Gln Lys Leu Lys  Asp Tyr Glu 
    1295                 1300                 1305             


Asp Leu  Arg Glu Asp Met Arg  Gly Lys Glu Leu Glu  Val Lys Asn 
    1310                 1315                 1320             


Leu Leu  Glu Lys Gly Lys Thr  Glu Gln Gln Thr Ala  Asp Gln Leu 
    1325                 1330                 1335             


Leu Ala  Arg Ala Asp Ala Ala  Lys Ala Leu Ala Glu  Glu Ala Ala 
    1340                 1345                 1350             


Lys Lys  Gly Arg Asp Thr Leu  Gln Glu Ala Asn Asp  Ile Leu Asn 
    1355                 1360                 1365             


Asn Leu  Lys Asp Phe Asp Arg  Arg Val Asn Asp Asn  Lys Thr Ala 
    1370                 1375                 1380             


Ala Glu  Glu Ala Leu Arg Lys  Ile Pro Ala Ile Asn  Gln Thr Ile 
    1385                 1390                 1395             


Thr Glu  Ala Asn Glu Lys Thr  Arg Glu Ala Gln Gln  Ala Leu Gly 
    1400                 1405                 1410             


Ser Ala  Ala Ala Asp Ala Thr  Glu Ala Lys Asn Lys  Ala His Glu 
    1415                 1420                 1425             


Ala Glu  Arg Ile Ala Ser Ala  Val Gln Lys Asn Ala  Thr Ser Thr 
    1430                 1435                 1440             


Lys Ala  Glu Ala Glu Arg Thr  Phe Ala Glu Val Thr  Asp Leu Asp 
    1445                 1450                 1455             


Asn Glu  Val Asn Asn Met Leu  Lys Gln Leu Gln Glu  Ala Glu Lys 
    1460                 1465                 1470             


Glu Leu  Lys Arg Lys Gln Asp  Asp Ala Asp Gln Asp  Met Met Met 
    1475                 1480                 1485             


Ala Gly  Met Ala Ser Gln Ala  Ala Gln Glu Ala Glu  Ile Asn Ala 
    1490                 1495                 1500             


Arg Lys  Ala Lys Asn Ser Val  Thr Ser Leu Leu Ser  Ile Ile Asn 
    1505                 1510                 1515             


Asp Leu  Leu Glu Gln Leu Gly  Gln Leu Asp Thr Val  Asp Leu Asn 
    1520                 1525                 1530             


Lys Leu  Asn Glu Ile Glu Gly  Thr Leu Asn Lys Ala  Lys Asp Glu 
    1535                 1540                 1545             


Met Lys  Val Ser Asp Leu Asp  Arg Lys Val Ser Asp  Leu Glu Asn 
    1550                 1555                 1560             


Glu Ala  Lys Lys Gln Glu Ala  Ala Ile Met Asp Tyr  Asn Arg Asp 
    1565                 1570                 1575             


Ile Glu  Glu Ile Met Lys Asp  Ile Arg Asn Leu Glu  Asp Ile Arg 
    1580                 1585                 1590             


Lys Thr  Leu Pro Ser Gly Cys  Phe Asn Thr Pro Ser  Ile Glu Lys 
    1595                 1600                 1605             


Pro 
    


<210> 57
<211> 3604
<212> DNA
<213> Homo sapiens

<400> 57
gggagaagga ggaggccggg ggaaggagga gacaggagga ggagggacca cggggtggag       60

gggagataga cccagcccag agctctgagt ggtttcctgt tgcctgtctc taaacccctc      120

cacattcccg cggtccttca gactgcccgg agagcgcgct ctgcctgccg cctgcctgcc      180

tgccactgag ggttcccagc accatgaggg cctggatctt ctttctcctt tgcctggccg      240

ggagggcctt ggcagcccct cagcaagaag ccctgcctga tgagacagag gtggtggaag      300

aaactgtggc agaggtgact gaggtatctg tgggagctaa tcctgtccag gtggaagtag      360

gagaatttga tgatggtgca gaggaaaccg aagaggaggt ggtggcggaa aatccctgcc      420

agaaccacca ctgcaaacac ggcaaggtgt gcgagctgga tgagaacaac acccccatgt      480

gcgtgtgcca ggaccccacc agctgcccag cccccattgg cgagtttgag aaggtgtgca      540

gcaatgacaa caagaccttc gactcttcct gccacttctt tgccacaaag tgcaccctgg      600

agggcaccaa gaagggccac aagctccacc tggactacat cgggccttgc aaatacatcc      660

ccccttgcct ggactctgag ctgaccgaat tccccctgcg catgcgggac tggctcaaga      720

acgtcctggt caccctgtat gagagggatg aggacaacaa ccttctgact gagaagcaga      780

agctgcgggt gaagaagatc catgagaatg agaagcgcct ggaggcagga gaccaccccg      840

tggagctgct ggcccgggac ttcgagaaga actataacat gtacatcttc cctgtacact      900

ggcagttcgg ccagctggac cagcacccca ttgacgggta cctctcccac accgagctgg      960

ctccactgcg tgctcccctc atccccatgg agcattgcac cacccgcttt ttcgagacct     1020

gtgacctgga caatgacaag tacatcgccc tggatgagtg ggccggctgc ttcggcatca     1080

agcagaagga tatcgacaag gatcttgtga tctaaatcca ctccttccac agtaccggat     1140

tctctcttta accctcccct tcgtgtttcc cccaatgttt aaaatgtttg gatggtttgt     1200

tgttctgcct ggagacaagg tgctaacata gatttaagtg aatacattaa cggtgctaaa     1260

aatgaaaatt ctaacccaag acatgacatt cttagctgta acttaactat taaggccttt     1320

tccacacgca ttaatagtcc catttttctc ttgccatttg tagctttgcc cattgtctta     1380

ttggcacatg ggtggacacg gatctgctgg gctctgcctt aaacacacat tgcagcttca     1440

acttttctct ttagtgttct gtttgaaact aatacttacc gagtcagact ttgtgttcat     1500

ttcatttcag ggtcttggct gcctgtgggc ttccccaggt ggcctggagg tgggcaaagg     1560

gaagtaacag acacacgatg ttgtcaagga tggttttggg actagaggct cagtggtggg     1620

agagatccct gcagaaccca ccaaccagaa cgtggtttgc ctgaggctgt aactgagaga     1680

aagattctgg ggctgtgtta tgaaaatata gacattctca cataagccca gttcatcacc     1740

atttcctcct ttacctttca gtgcagtttc ttttcacatt aggctgttgg ttcaaacttt     1800

tgggagcacg gactgtcagt tctctgggaa gtggtcagcg catcctgcag ggcttctcct     1860

cctctgtctt ttggagaacc agggctcttc tcaggggctc tagggactgc caggctgttt     1920

cagccaggaa ggccaaaatc aagagtgaga tgtagaaagt tgtaaaatag aaaaagtgga     1980

gttggtgaat cggttgttct ttcctcacat ttggatgatt gtcataaggt ttttagcatg     2040

ttcctccttt tcttcaccct cccctttttt cttctattaa tcaagagaaa cttcaaagtt     2100

aatgggatgg tcggatctca caggctgaga actcgttcac ctccaagcat ttcatgaaaa     2160

agctgcttct tattaatcat acaaactctc accatgatgt gaagagtttc acaaatcctt     2220

caaaataaaa agtaatgact tagaaactgc cttcctgggt gatttgcatg tgtcttagtc     2280

ttagtcacct tattatcctg acacaaaaac acatgagcat acatgtctac acatgactac     2340

acaaatgcaa acctttgcaa acacattatg cttttgcaca cacacacctg tacacacaca     2400

ccggcatgtt tatacacagg gagtgtatgg ttcctgtaag cactaagtta gctgttttca     2460

tttaatgacc tgtggtttaa cccttttgat cactaccacc attatcagca ccagactgag     2520

cagctatatc cttttattaa tcatggtcat tcattcattc attcattcac aaaatattta     2580

tgatgtattt actctgcacc aggtcccatg ccaagcactg gggacacagt tatggcaaag     2640

tagacaaagc atttgttcat ttggagctta gagtccagga ggaatacatt agataatgac     2700

acaatcaaat ataaattgca agatgtcaca ggtgtgatga agggagagta ggagagacca     2760

tgagtatgtg taacaggagg acacagcatt attctagtgc tgtactgttc cgtacggcag     2820

ccactaccca catgtaactt tttaagattt aaatttaaat tagttaacat tcaaaacgca     2880

gctccccaat cacactagca acatttcaag tgcttgagag ccatgcatga ttagtggtta     2940

ccctattgaa taggtcagaa gtagaatctt ttcatcatca cagaaagttc tattggacag     3000

tgctcttcta gatcatcata agactacaga gcacttttca aagctcatgc atgttcatca     3060

tgttagtgtc gtattttgag ctggggtttt gagactcccc ttagagatag agaaacagac     3120

ccaagaaatg tgctcaattg caatgggcca catacctaga tctccagatg tcatttcccc     3180

tctcttattt taagttatgt taagattact aaaacaataa aagctcctaa aaaatcaaac     3240

tgtattctgg tgttctcttc tacacagtgg gagggcgagc agtaggagag attggcccat     3300

ttggtgctgg ccatttgagg aatgcaagcc cagcactagt ctcataatct ctaggaatct     3360

gtagagagag gaattgaagt aaatttcagc attggctcat tcagtcattc ggcgacattc     3420

atcaggtacc tgcaatgtgt taggggatct tatgagtagg cagcgtgcgt gatccttgct     3480

cccctggagc tttctaacat tctagcaggc agaccacaca taaatttgca atactgtttc     3540

tgataaaaac gtgctgtaaa ggaaataaag cagagaacta tcatggaaaa aaaaaaaaaa     3600

aaaa                                                                  3604


<210> 58
<211> 303
<212> PRT
<213> Homo sapiens

<400> 58
Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Ala Pro Gln Gln Glu Ala Leu Pro Asp Glu Thr Glu Val Val Glu 
            20                  25                  30          


Glu Thr Val Ala Glu Val Thr Glu Val Ser Val Gly Ala Asn Pro Val 
        35                  40                  45              


Gln Val Glu Val Gly Glu Phe Asp Asp Gly Ala Glu Glu Thr Glu Glu 
    50                  55                  60                  


Glu Val Val Ala Glu Asn Pro Cys Gln Asn His His Cys Lys His Gly 
65                  70                  75                  80  


Lys Val Cys Glu Leu Asp Glu Asn Asn Thr Pro Met Cys Val Cys Gln 
                85                  90                  95      


Asp Pro Thr Ser Cys Pro Ala Pro Ile Gly Glu Phe Glu Lys Val Cys 
            100                 105                 110         


Ser Asn Asp Asn Lys Thr Phe Asp Ser Ser Cys His Phe Phe Ala Thr 
        115                 120                 125             


Lys Cys Thr Leu Glu Gly Thr Lys Lys Gly His Lys Leu His Leu Asp 
    130                 135                 140                 


Tyr Ile Gly Pro Cys Lys Tyr Ile Pro Pro Cys Leu Asp Ser Glu Leu 
145                 150                 155                 160 


Thr Glu Phe Pro Leu Arg Met Arg Asp Trp Leu Lys Asn Val Leu Val 
                165                 170                 175     


Thr Leu Tyr Glu Arg Asp Glu Asp Asn Asn Leu Leu Thr Glu Lys Gln 
            180                 185                 190         


Lys Leu Arg Val Lys Lys Ile His Glu Asn Glu Lys Arg Leu Glu Ala 
        195                 200                 205             


Gly Asp His Pro Val Glu Leu Leu Ala Arg Asp Phe Glu Lys Asn Tyr 
    210                 215                 220                 


Asn Met Tyr Ile Phe Pro Val His Trp Gln Phe Gly Gln Leu Asp Gln 
225                 230                 235                 240 


His Pro Ile Asp Gly Tyr Leu Ser His Thr Glu Leu Ala Pro Leu Arg 
                245                 250                 255     


Ala Pro Leu Ile Pro Met Glu His Cys Thr Thr Arg Phe Phe Glu Thr 
            260                 265                 270         


Cys Asp Leu Asp Asn Asp Lys Tyr Ile Ala Leu Asp Glu Trp Ala Gly 
        275                 280                 285             


Cys Phe Gly Ile Lys Gln Lys Asp Ile Asp Lys Asp Leu Val Ile 
    290                 295                 300             


<210> 59
<211> 2715
<212> DNA
<213> Homo sapiens

<400> 59
atgcgccgcc cggcttggaa ggtggggctt cgcccggggg cgggccttcg ccgggggtag       60

gactccggcc ttggtggcgg gtggctggcg gttccgttag gtctgaggga gcgatggcgg      120

tacgcgcgtt gaagctgctg accacactgc tggctgtcgt ggccgctgcc tcccaagccg      180

aggtcgagtc cgaggcagga tggggcatgg tgacgcctga tctgctcttc gccgagggga      240

ccgcagccta cgcgcgcggg gactggcccg gggtggtcct gagcatggaa cgggcgctgc      300

gctcccgggc agccctccgc gcccttcgcc tgcgctgccg cacccagtgt gccgccgact      360

tcccgtggga gctggacccc gactggtccc ccagcccggc ccaggcctcg ggcgccgccg      420

ccctgcgcga cctgagcttc ttcgggggcc ttctgcgtcg cgctgcctgc ctgcgccgct      480

gcctcgggcc gccggccgcc cactcgctca gcgaagagat ggagctggag ttccgcaagc      540

ggagccccta caactacctg caggtcgcct acttcaagat caacaagttg gagaaagctg      600

ttgctgcagc acacaccttc ttcgtgggca atcctgagca catggaaatg cagcagaacc      660

tagactatta ccaaaccatg tctggagtga aggaggccga cttcaaggat cttgagactc      720

aaccccatat gcaagaattt cgactgggag tgcgactcta ctcagaggaa cagccacagg      780

aagctgtgcc ccacctagag gcggcgctgc aagaatactt tgtggcctat gaggagtgcc      840

gtgccctctg cgaagggccc tatgactacg atggctacaa ctaccttgag tacaacgctg      900

acctcttcca ggccatcaca gatcattaca tccaggtcct caactgtaag cagaactgtg      960

tcacggagct tgcttcccac ccaagtcgag agaagccctt tgaagacttc ctcccatcgc     1020

attataatta tctgcagttt gcctactata acattgggaa ttatacacag gctgttgaat     1080

gtgccaagac ctatcttctc ttcttcccca atgacgaggt gatgaaccaa aatttggcct     1140

attatgcagc tatgcttgga gaagaacaca ccagatccat cggcccccgt gagagtgcca     1200

aggagtaccg acagcgaagc ctactggaaa aagaactgct tttcttcgct tatgatgttt     1260

ttggaattcc ctttgtggat ccggattcat ggactccaga agaagtgatt cccaagagat     1320

tgcaagagaa acagaagtca gaacgggaaa cagccgtacg catctcccag gagattggga     1380

accttatgaa ggaaatcgag acccttgtgg aagagaagac caaggagtca ctggatgtga     1440

gcagactgac ccgggaaggt ggccccctgc tgtatgaagg catcagtctc accatgaact     1500

ccaaactcct gaatggttcc cagcgggtgg tgatggacgg cgtaatctct gaccacgagt     1560

gtcaggagct gcagagactg accaatgtgg cagcaacctc aggagatggc taccggggtc     1620

agacctcccc acatactccc aatgaaaagt tctatggtgt cactgtcttc aaagccctca     1680

agctggggca agaaggcaaa gttcctctgc agagtgccca cctgtactac aacgtgacgg     1740

agaaggtgcg gcgcatcatg gagtcctact tccgcctgga tacgcccctc tacttttcct     1800

actctcatct ggtgtgccgc actgccatcg aagaggtcca ggcagagagg aaggatgata     1860

gtcatccagt ccacgtggac aactgcatcc tgaatgccga gaccctcgtg tgtgtcaaag     1920

agcccccagc ctacaccttc cgcgactaca gcgccatcct ttacctaaat ggggacttcg     1980

atggcggaaa cttttatttc actgaactgg atgccaagac cgtgacggca gaggtgcagc     2040

ctcagtgtgg aagagccgtg ggattctctt caggcactga aaacccacat ggagtgaagg     2100

ctgtcaccag ggggcagcgc tgtgccatcg ccctgtggtt caccctggac cctcgacaca     2160

gcgagcgggt gagagcagct cgagcgggac agggtgcagg cagatgacct ggtgaagatg     2220

ctcttcagcc cagaagagat ggacctctcc caggagcagc ccctggatgc ccagcagggc     2280

ccccccgaac ctgcacaaga gtctctctca ggcagtgaat cgaagcccaa ggatgagcta     2340

tgacagcgtc caggtcagac ggatgggtga ctagacccat ggagaggaac tcttctgcac     2400

tctgagctgg ccagcccctc ggggctgcag agcagtgagc ctacatctgc cactcagccg     2460

aggggaccct gctcacagcc ttctacatgg tgctactgct cttggagtgg acatgaccag     2520

acaccgcacc ccctggatct ggctgagggc tcaggacaca ggcccagcca cccccagggg     2580

cctccacagg ccgctgcatg acagcgatac agtacttaag tgtctgtgta gacaaccaaa     2640

gaataaatga ttcatggttt tttttacttg gtttgttcag acaatggaaa tttgcccatt     2700

ctgtcaaaaa aaaaa                                                      2715


<210> 60
<211> 697
<212> PRT
<213> Homo sapiens

<400> 60
Met Ala Val Arg Ala Leu Lys Leu Leu Thr Thr Leu Leu Ala Val Val 
1               5                   10                  15      


Ala Ala Ala Ser Gln Ala Glu Val Glu Ser Glu Ala Gly Trp Gly Met 
            20                  25                  30          


Val Thr Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg 
        35                  40                  45              


Gly Asp Trp Pro Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser 
    50                  55                  60                  


Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Gln Cys Ala 
65                  70                  75                  80  


Ala Asp Phe Pro Trp Glu Leu Asp Pro Asp Trp Ser Pro Ser Pro Ala 
                85                  90                  95      


Gln Ala Ser Gly Ala Ala Ala Leu Arg Asp Leu Ser Phe Phe Gly Gly 
            100                 105                 110         


Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Pro Ala 
        115                 120                 125             


Ala His Ser Leu Ser Glu Glu Met Glu Leu Glu Phe Arg Lys Arg Ser 
    130                 135                 140                 


Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Ile Asn Lys Leu Glu 
145                 150                 155                 160 


Lys Ala Val Ala Ala Ala His Thr Phe Phe Val Gly Asn Pro Glu His 
                165                 170                 175     


Met Glu Met Gln Gln Asn Leu Asp Tyr Tyr Gln Thr Met Ser Gly Val 
            180                 185                 190         


Lys Glu Ala Asp Phe Lys Asp Leu Glu Thr Gln Pro His Met Gln Glu 
        195                 200                 205             


Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu Glu Gln Pro Gln Glu Ala 
    210                 215                 220                 


Val Pro His Leu Glu Ala Ala Leu Gln Glu Tyr Phe Val Ala Tyr Glu 
225                 230                 235                 240 


Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr Asp Tyr Asp Gly Tyr Asn 
                245                 250                 255     


Tyr Leu Glu Tyr Asn Ala Asp Leu Phe Gln Ala Ile Thr Asp His Tyr 
            260                 265                 270         


Ile Gln Val Leu Asn Cys Lys Gln Asn Cys Val Thr Glu Leu Ala Ser 
        275                 280                 285             


His Pro Ser Arg Glu Lys Pro Phe Glu Asp Phe Leu Pro Ser His Tyr 
    290                 295                 300                 


Asn Tyr Leu Gln Phe Ala Tyr Tyr Asn Ile Gly Asn Tyr Thr Gln Ala 
305                 310                 315                 320 


Val Glu Cys Ala Lys Thr Tyr Leu Leu Phe Phe Pro Asn Asp Glu Val 
                325                 330                 335     


Met Asn Gln Asn Leu Ala Tyr Tyr Ala Ala Met Leu Gly Glu Glu His 
            340                 345                 350         


Thr Arg Ser Ile Gly Pro Arg Glu Ser Ala Lys Glu Tyr Arg Gln Arg 
        355                 360                 365             


Ser Leu Leu Glu Lys Glu Leu Leu Phe Phe Ala Tyr Asp Val Phe Gly 
    370                 375                 380                 


Ile Pro Phe Val Asp Pro Asp Ser Trp Thr Pro Glu Glu Val Ile Pro 
385                 390                 395                 400 


Lys Arg Leu Gln Glu Lys Gln Lys Ser Glu Arg Glu Thr Ala Val Arg 
                405                 410                 415     


Ile Ser Gln Glu Ile Gly Asn Leu Met Lys Glu Ile Glu Thr Leu Val 
            420                 425                 430         


Glu Glu Lys Thr Lys Glu Ser Leu Asp Val Ser Arg Leu Thr Arg Glu 
        435                 440                 445             


Gly Gly Pro Leu Leu Tyr Glu Gly Ile Ser Leu Thr Met Asn Ser Lys 
    450                 455                 460                 


Leu Leu Asn Gly Ser Gln Arg Val Val Met Asp Gly Val Ile Ser Asp 
465                 470                 475                 480 


His Glu Cys Gln Glu Leu Gln Arg Leu Thr Asn Val Ala Ala Thr Ser 
                485                 490                 495     


Gly Asp Gly Tyr Arg Gly Gln Thr Ser Pro His Thr Pro Asn Glu Lys 
            500                 505                 510         


Phe Tyr Gly Val Thr Val Phe Lys Ala Leu Lys Leu Gly Gln Glu Gly 
        515                 520                 525             


Lys Val Pro Leu Gln Ser Ala His Leu Tyr Tyr Asn Val Thr Glu Lys 
    530                 535                 540                 


Val Arg Arg Ile Met Glu Ser Tyr Phe Arg Leu Asp Thr Pro Leu Tyr 
545                 550                 555                 560 


Phe Ser Tyr Ser His Leu Val Cys Arg Thr Ala Ile Glu Glu Val Gln 
                565                 570                 575     


Ala Glu Arg Lys Asp Asp Ser His Pro Val His Val Asp Asn Cys Ile 
            580                 585                 590         


Leu Asn Ala Glu Thr Leu Val Cys Val Lys Glu Pro Pro Ala Tyr Thr 
        595                 600                 605             


Phe Arg Asp Tyr Ser Ala Ile Leu Tyr Leu Asn Gly Asp Phe Asp Gly 
    610                 615                 620                 


Gly Asn Phe Tyr Phe Thr Glu Leu Asp Ala Lys Thr Val Thr Ala Glu 
625                 630                 635                 640 


Val Gln Pro Gln Cys Gly Arg Ala Val Gly Phe Ser Ser Gly Thr Glu 
                645                 650                 655     


Asn Pro His Gly Val Lys Ala Val Thr Arg Gly Gln Arg Cys Ala Ile 
            660                 665                 670         


Ala Leu Trp Phe Thr Leu Asp Pro Arg His Ser Glu Arg Val Arg Ala 
        675                 680                 685             


Ala Arg Ala Gly Gln Gly Ala Gly Arg 
    690                 695         


<210> 61
<211> 4246
<212> DNA
<213> Homo sapiens

<400> 61
gctctcactc tggctgggag cagaaggcag cctcggtctc tgggcggcgg cggcggccca       60

ctctgccctg gccgcgctgt gtggtgaccg caggccccag acatgagggc ggcccgtgct      120

ctgctgcccc tgctgctgca ggcctgctgg acagccgcgc aggatgagcc ggagaccccg      180

agggccgtgg ccttccagga ctgccccgtg gacctgttct ttgtgctgga cacctctgag      240

agcgtggccc tgaggctgaa gccctacggg gccctcgtgg acaaagtcaa gtccttcacc      300

aagcgcttca tcgacaacct gagggacagg tactaccgct gtgaccgaaa cctggtgtgg      360

aacgcaggcg cgctgcacta cagtgacgag gtggagatca tccaaggcct cacgcgcatg      420

cctggcggcc gcgacgcact caaaagcagc gtggacgcgg tcaagtactt tgggaagggc      480

acctacaccg actgcgctat caagaagggg ctggagcagc tcctcgtggg gggctcccac      540

ctgaaggaga ataagtacct gattgtggtg accgacgggc accccctgga gggctacaag      600

gaaccctgtg gggggctgga ggatgctgtg aacgaggcca agcacctggg cgtcaaagtc      660

ttctcggtgg ccatcacacc cgaccacctg gagccgcgtc tgagcatcat cgccacggac      720

cacacgtacc ggcgcaactt cacggcggct gactggggcc agagccgcga cgcagaggag      780

gccatcagcc agaccatcga caccatcgtg gacatgatca aaaataacgt ggagcaagtg      840

tgctgctcct tcgaatgcca gcctgcaaga ggacctccgg ggctccgggg cgaccccggc      900

tttgagggag aacgaggcaa gccggggctc ccaggagaga agggagaagc cggagatcct      960

ggaagacccg gggacctcgg acctgttggg taccagggaa tgaagggaga aaaagggagc     1020

cgtggggaga agggctccag gggacccaag ggctacaagg gagagaaggg caagcgtggc     1080

atcgacgggg tggacggcgt gaagggggag atggggtacc caggcctgcc aggctgcaag     1140

ggctcgcccg ggtttgacgg cattcaagga ccccctggcc ccaagggaga ccccggtgcc     1200

tttggactga aaggagaaaa gggcgagcct ggagctgacg gggaggcggg gagaccaggg     1260

agctcgggac catctggaga cgagggccag ccgggagagc ctgggccccc cggagagaaa     1320

ggagaggcgg gcgacgaggg gaacccagga cctgacggtg cccccgggga gcggggtggc     1380

cctggagaga gaggaccacg ggggacccca ggcacgcggg gaccaagagg agaccctggt     1440

gaagctggcc cgcagggtga tcagggaaga gaaggccccg ttggtgtccc tggagacccg     1500

ggcgaggctg gccctatcgg acctaaaggc taccgaggcg atgagggtcc cccagggtcc     1560

gagggtgcca gaggagcccc aggacctgcc ggaccccctg gagacccggg gctgatgggt     1620

gaaaggggag aagacggccc cgctggaaat ggcaccgagg gcttccccgg cttccccggg     1680

tatccgggca acaggggcgc tcccgggata aacggcacga agggctaccc cggcctcaag     1740

ggggacgagg gagaagccgg ggaccccgga gacgataaca acgacattgc accccgagga     1800

gtcaaaggag caaaggggta ccggggtccc gagggccccc agggaccccc aggacaccaa     1860

ggaccgcctg ggccggacga atgcgagatt ttggacatca tcatgaaaat gtgctcttgc     1920

tgtgaatgca agtgcggccc catcgacctc ctgttcgtgc tggacagctc agagagcatt     1980

ggcctgcaga acttcgagat tgccaaggac ttcgtcgtca aggtcatcga ccggctgagc     2040

cgggacgagc tggtcaagtt cgagccaggg cagtcgtacg cgggtgtggt gcagtacagc     2100

cacagccaga tgcaggagca cgtgagcctg cgcagcccca gcatccggaa cgtgcaggag     2160

ctcaaggaag ccatcaagag cctgcagtgg atggcgggcg gcaccttcac gggggaggcc     2220

ctgcagtaca cgcgggacca gctgctgccg cccagcccga acaaccgcat cgccctggtc     2280

atcactgacg ggcgctcaga cactcagagg gacaccacac cgctcaacgt gctctgcagc     2340

cccggcatcc aggtggtctc cgtgggcatc aaagacgtgt ttgacttcat cccaggctca     2400

gaccagctca atgtcatttc ttgccaaggc ctggcaccat cccagggccg gcccggcctc     2460

tcgctggtca aggagaacta tgcagagctg ctggaggatg ccttcctgaa gaatgtcacc     2520

gcccagatct gcatagacaa gaagtgtcca gattacacct gccccatcac gttctcctcc     2580

ccggctgaca tcaccatcct gctggacggc tccgccagcg tgggcagcca caactttgac     2640

accaccaagc gcttcgccaa gcgcctggcc gagcgcttcc tcacagcggg caggacggac     2700

cccgcccacg acgtgcgggt ggcggtggtg cagtacagcg gcacgggcca gcagcgccca     2760

gagcgggcgt cgctgcagtt cctgcagaac tacacggccc tggccagtgc cgtcgatgcc     2820

atggacttta tcaacgacgc caccgacgtc aacgatgccc tgggctatgt gacccgcttc     2880

taccgcgagg cctcgtccgg cgctgccaag aagaggctgc tgctcttctc agatggcaac     2940

tcgcagggcg ccacgcccgc tgccatcgag aaggccgtgc aggaagccca gcgggcaggc     3000

atcgagatct tcgtggtggt cgtgggccgc caggtgaatg agccccacat ccgcgtcctg     3060

gtcaccggca agacggccga gtacgacgtg gcctacggcg agagccacct gttccgtgtc     3120

cccagctacc aggccctgct ccgcggtgtc ttccaccaga cagtctccag gaaggtggcg     3180

ctgggctagc ccaccctgca cgccggcacc aaaccctgtc ctcccacccc tccccactca     3240

tcactaaaca gagtaaaatg tgatgcgaat tttcccgacc aacctgattc gctagatttt     3300

ttttaaggaa aagcttggaa agccaggaca caacgctgct gcctgctttg tgcagggtcc     3360

tccggggctc agccctgagt tggcatcacc tgcgcagggc cctctggggc tcagccctga     3420

gctagtgtca cctgcacagg gccctctgag gctcagccct gagctggcgt cacctgtgca     3480

gggccctctg gggctcagcc ctgagctggc ctcacctggg ttccccaccc cgggctctcc     3540

tgccctgccc tcctgcccgc cctccctcct gcctgcgcag ctccttccct aggcacctct     3600

gtgctgcatc ccaccagcct gagcaagacg ccctctcggg gcctgtgccg cactagcctc     3660

cctctcctct gtccccatag ctggtttttc ccaccaatcc tcacctaaca gttactttac     3720

aattaaactc aaagcaagct cttctcctca gcttggggca gccattggcc tctgtctcgt     3780

tttgggaaac caaggtcagg aggccgttgc agacataaat ctcggcgact cggccccgtc     3840

tcctgagggt cctgctggtg accggcctgg accttggccc tacagccctg gaggccgctg     3900

ctgaccagca ctgaccccga cctcagagag tactcgcagg ggcgctggct gcactcaaga     3960

ccctcgagat taacggtgct aaccccgtct gctcctccct cccgcagaga ctggggcctg     4020

gactggacat gagagcccct tggtgccaca gagggctgtg tcttactaga aacaacgcaa     4080

acctctcctt cctcagaata gtgatgtgtt cgacgtttta tcaaaggccc cctttctatg     4140

ttcatgttag ttttgctcct tctgtgtttt tttctgaacc atatccatgt tgctgacttt     4200

tccaaataaa ggttttcact cctctaaaaa aaaaaaaaaa aaaaaa                    4246


<210> 62
<211> 1028
<212> PRT
<213> Homo sapiens

<400> 62
Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp 
1               5                   10                  15      


Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln 
            20                  25                  30          


Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val 
        35                  40                  45              


Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser 
    50                  55                  60                  


Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys 
65                  70                  75                  80  


Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu 
                85                  90                  95      


Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala 
            100                 105                 110         


Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr 
        115                 120                 125             


Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly 
    130                 135                 140                 


Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val 
                165                 170                 175     


Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr 
            180                 185                 190         


Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr 
        195                 200                 205             


Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala 
    210                 215                 220                 


Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys 
225                 230                 235                 240 


Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg 
                245                 250                 255     


Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly 
            260                 265                 270         


Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg 
        275                 280                 285             


Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys 
    290                 295                 300                 


Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Pro Lys Gly Tyr Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Lys Arg Gly Ile Asp Gly Val Asp Gly Val Lys Gly Glu 
                325                 330                 335     


Met Gly Tyr Pro Gly Leu Pro Gly Cys Lys Gly Ser Pro Gly Phe Asp 
            340                 345                 350         


Gly Ile Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Phe Gly 
        355                 360                 365             


Leu Lys Gly Glu Lys Gly Glu Pro Gly Ala Asp Gly Glu Ala Gly Arg 
    370                 375                 380                 


Pro Gly Ser Ser Gly Pro Ser Gly Asp Glu Gly Gln Pro Gly Glu Pro 
385                 390                 395                 400 


Gly Pro Pro Gly Glu Lys Gly Glu Ala Gly Asp Glu Gly Asn Pro Gly 
                405                 410                 415     


Pro Asp Gly Ala Pro Gly Glu Arg Gly Gly Pro Gly Glu Arg Gly Pro 
            420                 425                 430         


Arg Gly Thr Pro Gly Thr Arg Gly Pro Arg Gly Asp Pro Gly Glu Ala 
        435                 440                 445             


Gly Pro Gln Gly Asp Gln Gly Arg Glu Gly Pro Val Gly Val Pro Gly 
    450                 455                 460                 


Asp Pro Gly Glu Ala Gly Pro Ile Gly Pro Lys Gly Tyr Arg Gly Asp 
465                 470                 475                 480 


Glu Gly Pro Pro Gly Ser Glu Gly Ala Arg Gly Ala Pro Gly Pro Ala 
                485                 490                 495     


Gly Pro Pro Gly Asp Pro Gly Leu Met Gly Glu Arg Gly Glu Asp Gly 
            500                 505                 510         


Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly Phe Pro Gly Tyr Pro 
        515                 520                 525             


Gly Asn Arg Gly Ala Pro Gly Ile Asn Gly Thr Lys Gly Tyr Pro Gly 
    530                 535                 540                 


Leu Lys Gly Asp Glu Gly Glu Ala Gly Asp Pro Gly Asp Asp Asn Asn 
545                 550                 555                 560 


Asp Ile Ala Pro Arg Gly Val Lys Gly Ala Lys Gly Tyr Arg Gly Pro 
                565                 570                 575     


Glu Gly Pro Gln Gly Pro Pro Gly His Gln Gly Pro Pro Gly Pro Asp 
            580                 585                 590         


Glu Cys Glu Ile Leu Asp Ile Ile Met Lys Met Cys Ser Cys Cys Glu 
        595                 600                 605             


Cys Lys Cys Gly Pro Ile Asp Leu Leu Phe Val Leu Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Leu Gln Asn Phe Glu Ile Ala Lys Asp Phe Val Val Lys 
625                 630                 635                 640 


Val Ile Asp Arg Leu Ser Arg Asp Glu Leu Val Lys Phe Glu Pro Gly 
                645                 650                 655     


Gln Ser Tyr Ala Gly Val Val Gln Tyr Ser His Ser Gln Met Gln Glu 
            660                 665                 670         


His Val Ser Leu Arg Ser Pro Ser Ile Arg Asn Val Gln Glu Leu Lys 
        675                 680                 685             


Glu Ala Ile Lys Ser Leu Gln Trp Met Ala Gly Gly Thr Phe Thr Gly 
    690                 695                 700                 


Glu Ala Leu Gln Tyr Thr Arg Asp Gln Leu Leu Pro Pro Ser Pro Asn 
705                 710                 715                 720 


Asn Arg Ile Ala Leu Val Ile Thr Asp Gly Arg Ser Asp Thr Gln Arg 
                725                 730                 735     


Asp Thr Thr Pro Leu Asn Val Leu Cys Ser Pro Gly Ile Gln Val Val 
            740                 745                 750         


Ser Val Gly Ile Lys Asp Val Phe Asp Phe Ile Pro Gly Ser Asp Gln 
        755                 760                 765             


Leu Asn Val Ile Ser Cys Gln Gly Leu Ala Pro Ser Gln Gly Arg Pro 
    770                 775                 780                 


Gly Leu Ser Leu Val Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala 
785                 790                 795                 800 


Phe Leu Lys Asn Val Thr Ala Gln Ile Cys Ile Asp Lys Lys Cys Pro 
                805                 810                 815     


Asp Tyr Thr Cys Pro Ile Thr Phe Ser Ser Pro Ala Asp Ile Thr Ile 
            820                 825                 830         


Leu Leu Asp Gly Ser Ala Ser Val Gly Ser His Asn Phe Asp Thr Thr 
        835                 840                 845             


Lys Arg Phe Ala Lys Arg Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg 
    850                 855                 860                 


Thr Asp Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly 
865                 870                 875                 880 


Thr Gly Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn 
                885                 890                 895     


Tyr Thr Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp 
            900                 905                 910         


Ala Thr Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg 
        915                 920                 925             


Glu Ala Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp 
    930                 935                 940                 


Gly Asn Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln 
945                 950                 955                 960 


Glu Ala Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg 
                965                 970                 975     


Gln Val Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala 
            980                 985                 990         


Glu Tyr Asp Val Ala Tyr Gly Glu  Ser His Leu Phe Arg  Val Pro Ser 
        995                 1000                 1005             


Tyr Gln  Ala Leu Leu Arg Gly  Val Phe His Gln Thr  Val Ser Arg 
    1010                 1015                 1020             


Lys Val  Ala Leu Gly 
    1025             


<210> 63
<211> 6668
<212> DNA
<213> Homo sapiens

<400> 63
aggctggcgt ccccgccccg aaagcactgg gcccgccgcg tcgcaccgtc ctctttcctt       60

tccttctccc tccccttttc ccttccttcg tcccttcctt ccttcctttc gccgggcgcg      120

atggagccgg ggcgccgggg ggccgcggcg ctgctagcgc tgctgtgcgt ggcctgcgcg      180

ctgcgcgccg ggcgcgccca atacgaacgc tacagcttcc gcagcttccc acgggacgag      240

ctgatgccgc tcgagtcggc ctaccggcac gcgctggaca agtacagcgg cgagcactgg      300

gccgagagcg tgggctacct ggagatcagc ctgcggctgc accgcttgct gcgcgacagc      360

gaggccttct gccaccgcaa ctgcagcgcc gcgccgcagc ccgagcccgc cgccggcctc      420

gccagctatc ccgagctgcg cctcttcggg ggcctgctgc gccgcgcgca ctgcctcaag      480

cgctgcaagc agggcctgcc agccttccgc cagtcccagc ccagccgcga ggtgctggcg      540

gacttccagc gccgcgagcc ctacaagttc ctgcagttcg cttacttcaa ggcaaataat      600

ctccccaaag ccatcgccgc tgctcacacc tttctactga agcatcctga tgacgaaatg      660

atgaagagga acatggcata ttataagagc ctgcctggtg ccgaggacta cattaaagac      720

ctggaaacca agtcatatga aagcctgttc atccgagcag tgcgggcata caacggtgag      780

aactggagaa catccatcac agacatggag ctggcccttc ccgacttctt caaagccttt      840

tacgagtgtc tcgcagcctg cgagggttcc agggagatca aggacttcaa ggatttctac      900

ctttccatag cagatcatta tgtagaagtt ctggaatgca aaatacagtg tgaagagaac      960

ctcaccccag ttataggagg ctatccggtt gagaaatttg tggctaccat gtatcattac     1020

ttgcagtttg cctattataa gttgaacgac ctgaagaatg cagccccctg tgcagtcagc     1080

tatctgctct ttgatcagaa tgacaaggtc atgcagcaga acctggtgta ttaccagtac     1140

cacagggaca cttggggcct ctcggatgag cacttccagc ccagacctga agcagttcag     1200

ttctttaatg tgaccacact ccagaaggag ctgtatgact ttgctaagga aaatataatg     1260

gatgatgatg agggagaagt tgtggaatat gtggatgacc tcttggaact ggaggagacc     1320

agctagccca cagcaaccaa agagacttcc tcttggcgtt caggaaacac agattctttg     1380

tccttttccc aacagcccag gctgttgata cctcagagcc ttctctttac tctccaaagt     1440

gaaagggaag cccccgtctc tctaactgca tgtcatcagg ggtgagcctg cctttcctat     1500

cttcacacct gccacctcat gttcacacct atctttctca cctttttttt gagatggagt     1560

ctcgctctct tgcccaggct ggagtgcaat ggcacgttct cagctcactg caacctccgc     1620

ctcttgggtt caagcaattc tgctgcatca gcctcccgag tacctgggat tacaggcatg     1680

tgccaccacg cccggctaat tttgtatttt tagtagagac ggggttttgc catgttggcc     1740

aggctggtct cgaactcttg acttcagatg atccatctgc cttggcctcc cacagtgctg     1800

ggattacagg cgtgagccac catgcccggc ctctttctca cctttacacc tgtcttctta     1860

tcctcacatc tgttttcaca ccttcatccc tgtcttcctc atgttcacac ttgtcttccc     1920

catgttcata gctgcctttc ttaccatttt ggtttgaagg gcagtcttct ctggcttgtt     1980

tttttgtttt tcccagaaaa tcagtattat tttttaaata agaaaaacat tcctagaaga     2040

tgataattgt gaaaacctcc tttggcttat ttgcttttcc agattttagt ctcctttctc     2100

cccatccggg aaagatggtg gaagacatag gctaaatttc tccagcctca caatggtctt     2160

cacttggtct gacttgtacc aattctagca cccactgaaa aacaagttga gtagagagtg     2220

tagagtgcag aaatgtggct tttgccccac tttgcatctc caaaattaca acggttggcc     2280

gatcccattt gaggacaatg cttagttata agtctccgag ttggaaaagg aagaaagcca     2340

gagctgtcta gtttcattca ttctttcagt aaatatttat tgagtaccta ctgtgtgcta     2400

ggcattgacc tgggaactag agatacttca cagaataaca gggaaagttc cctgtgctca     2460

tggagcttac attctacagg gagaaagaga tagccaatac ataggaataa atatatacaa     2520

ggtatcatgt agtgataatt gctgtggaga aaaataaagc aggggaggga gtaagaaatc     2580

ctggagatga ggctgcagtt ttaaatgggg cctcactggg aatgtgacgt tgagcagaga     2640

cgttagggaa gtggatcctg gacaaggcat tccaggcaga ggaacaggat gtgcactgcc     2700

ccaaagtgag aacttgctct acgtggtcag gaaagagcag ggagaccaag cagagtcgtg     2760

ggcaggggta gaatggaagg agaggcggct ggggaggaca ggtggtggag ggccttggct     2820

tctgctaagt gagatgggaa ccactggagg gtttgaacag aggagtgcct tgattgattt     2880

atattttgca agggtcattc tagctgccat attgtgaaaa actttagtgg acaagggcag     2940

aaggaagagg gaagacctgt taggaagcta ctgcaaggtt ccaggcttgg gcctgggcca     3000

cagcaacagc agtggtcaaa tatctagatt tattttgaaa agagccaata ggatttgctg     3060

agagtttgaa tgtggagtgt aagagaagga agagttaatg atgacattaa ggtttttggc     3120

ctgaatagca ggaaagatgg agttaccagt tactgaaata gggaaggatg ggctgggtaa     3180

gtatggaatt tggtgcaaag caggctgtct gtggttggaa tgggaggttc tggctgcaaa     3240

tcaaagtgga gagttctctc aggtcaggtc tgcagcagag ctcgagacag ggatctgaat     3300

gcacttggtt tattgttggg ggtgctctca gaaggaacct gtgaaagcct ttatcagtca     3360

tttattggct gtgagaagtt ctctgggagt gtgggtacat ttgaaggcaa gtgacttcag     3420

ttgagggcaa gtctctggaa aagaggctgt aggcatctgg cagctaccat gcatggtagt     3480

gtgttggggg tgggggtcct gggcactggc tgtgtgaagg gatctggcag ggcaccacag     3540

cgccccctac tgaaccatca gcatgtcagt ggcatttaaa gccatgcagc tggaggggcc     3600

actgagattg tctctgagta ttactgagaa gcaacagaaa agagccatgg atggagccct     3660

tgggctctct gggaaatggg aaatcagcca aaggactgag aaggagttac cttaaggtca     3720

gagaaaacca agagagtgtg gtgttctgga agctgagctt tctttattca acctcattcc     3780

cttctccaaa taagccactt gtgtagttgg gcccctccag ggttgaaggc aagaggagaa     3840

aggcacagcg tttgggaaac aagacttttc ctgcaatagc ctgggaagga ataaaaggat     3900

agagtgtttg ggtttttgtg taatggtggt taattggggt ggaacactca cacgttgtgc     3960

tttttctggg cttcccttat cccccagaac actctaccaa cctcggggaa ctcgggcaca     4020

tccttctgtt tctccttcag ctctatcctg ctttcctcat cccttctgac accacgtcct     4080

cactcacctg cacaagaatc cctgcatcag gttctccttt gagggtaccc acccaggaca     4140

gtcccctacc acttctgtct tgggctgaag ttgcccacgt ccacaaaatc tgtactccca     4200

gcgggggtgt ttggcccgag gagtcagtgt tattactggt ggatgcaccg tgtccacagc     4260

agcccccaat cccagcgatg cgtcagatct tacgtggctt cctgctgggg gagatggcct     4320

tcacccacgg gatgccgggt tctcctttct ttcctcaccc caacctttac tccaccagag     4380

aaacttcctt ttgaactcag tggggaagag ggtgatgaga caggactaga aagtagtggg     4440

ggacccagcg agtggacgcc ctgctccggg attcctgagt ctgtaaatag tgtgcccagc     4500

agctgtgaac tccccttata gcctcaggct gcagtgtcct tcccagctgt gtgagaaaat     4560

gaaagccgac gtccacaggg acccaggcag ggttgggtgt tgtgactcac tccacctctg     4620

tgccctgcag aggtactgtt gggtccttgt cttgtgagcc tggggtgagc tctctgtaca     4680

tgttgttgtt ccacgtatgg gttgacttgg catgctgggg ggtcctcgtt cactctctga     4740

agttggcctc ctttcactgg ggattgaaaa gcacctccac ccctacccta gtgatgtccc     4800

ctgaggaccc gggtgatagt acagtcaata ttgtcagtac tttgctttga ttgaaggctg     4860

tagagctgag ttaccaaaat ttctatttca aaggaaacca aaccttaaaa aaaaaaaaca     4920

aaaactgggc tgggtcttcc aaacctacca tgaaaccctg gtgtgcaggc tgcactcaat     4980

gacctcaacc caacacctcc ctgagtgtgc ttcttggaag agcctagaag attcctggat     5040

ggagacccca ttggttcagc ctcaagtctg gcccgtcttc gaaaaaacaa acacatttgt     5100

aagctttgtg ggagcttcca ggcctgctct aagatgcctt gcttgtcctt tgacccatca     5160

gcatggagct cagtggttgc tgtttggttc tgcaggctgg tggggaggcc gcccatcgtg     5220

gtggggcatc tgtccagccc cattgccact cagggcatcc aaacaggagg cacccgctgg     5280

gaagggtcta aagatactcc ttgtggccac tgctactgtt cacacttgac ttgtggagaa     5340

gcgaagggct gaggggaggt ttgtgtacac ccatgtattt aaaagtgact gactgactga     5400

aatgagcaca taccgacata tgcaacatac taataccttc ctgattttcg agactttcta     5460

attactacaa ctaacctgtt gtgctcacct ctggaattca gaaagagagc cactgcgagc     5520

actgaccaca agggctgcct taggaaggaa atgtgtgctt tcaggagttc ttattagggg     5580

aattttaaga gcacaaaaat tttattgaac ccaccttagt gacaaacaga aaatgatttg     5640

ttagattgtc agttggaagg ggtttattat gactgctggt gaaataaaca gtgaccagtt     5700

tctgccaaca tttatggaaa taacgtttct aggttttaaa tgtgagccgt aaactgaagc     5760

tacttcagtt aaaaaaaaaa aaatcaatac ttaaactgta gggaaaaggt ggattggtgc     5820

cagagaaaac attatttaat agtgtcagaa catggaactg caacacagtt tgtagcaagg     5880

cactgagaaa aacccacaac taatccttca tcgcagctgt ctgaactctt gatcatctgc     5940

catcccccaa acagtgactt ctttttttct ggtgactcca ggcctgaatg acctagtgtg     6000

gagagtttaa actatgtaca agggaggaaa gaaaaaaagg aaaggaacct taagtaagcc     6060

tcagccaaag gttttatgca ttggacttcc tgtgcctgcc cccaggggca agactgatcc     6120

ccatgcctgt gcccatgaca tctccctgaa agaggacacc atgacagccc ggctttgcct     6180

tgactgaccc actgctaccc cagaaataag aatcaagagc agctattgtt atccttagag     6240

tgttttccgt ctagggccgg ctcgtgaaca gccacatatc cttgcacctg acactgtccc     6300

cacacaaata gctggctttc gttgcttgtt gaatgaatga gtgagttggc tctatatccc     6360

cttggagctg gccggtaaga tattagtgcc tcattttaca agaagagaat aggaaggaat     6420

taagcaattt ggccaacaga tacaagatag attccagagt tttatctccc actttagggt     6480

ggcagccagt aggccaaact ccaaagaccg ttgctgatgt ctttttctgc ctcccctctt     6540

tgggttagtg tggtatgtac aagctcactc ttgttgaaaa ttagaaaata gttgaaaaca     6600

aaaggttttt gtttttcttt ttaaatcaca ttaaatgttt tacattgctt aaaaaaaaaa     6660

aaaaaaaa                                                              6668


<210> 64
<211> 401
<212> PRT
<213> Homo sapiens

<400> 64
Met Glu Pro Gly Arg Arg Gly Ala Ala Ala Leu Leu Ala Leu Leu Cys 
1               5                   10                  15      


Val Ala Cys Ala Leu Arg Ala Gly Arg Ala Gln Tyr Glu Arg Tyr Ser 
            20                  25                  30          


Phe Arg Ser Phe Pro Arg Asp Glu Leu Met Pro Leu Glu Ser Ala Tyr 
        35                  40                  45              


Arg His Ala Leu Asp Lys Tyr Ser Gly Glu His Trp Ala Glu Ser Val 
    50                  55                  60                  


Gly Tyr Leu Glu Ile Ser Leu Arg Leu His Arg Leu Leu Arg Asp Ser 
65                  70                  75                  80  


Glu Ala Phe Cys His Arg Asn Cys Ser Ala Ala Pro Gln Pro Glu Pro 
                85                  90                  95      


Ala Ala Gly Leu Ala Ser Tyr Pro Glu Leu Arg Leu Phe Gly Gly Leu 
            100                 105                 110         


Leu Arg Arg Ala His Cys Leu Lys Arg Cys Lys Gln Gly Leu Pro Ala 
        115                 120                 125             


Phe Arg Gln Ser Gln Pro Ser Arg Glu Val Leu Ala Asp Phe Gln Arg 
    130                 135                 140                 


Arg Glu Pro Tyr Lys Phe Leu Gln Phe Ala Tyr Phe Lys Ala Asn Asn 
145                 150                 155                 160 


Leu Pro Lys Ala Ile Ala Ala Ala His Thr Phe Leu Leu Lys His Pro 
                165                 170                 175     


Asp Asp Glu Met Met Lys Arg Asn Met Ala Tyr Tyr Lys Ser Leu Pro 
            180                 185                 190         


Gly Ala Glu Asp Tyr Ile Lys Asp Leu Glu Thr Lys Ser Tyr Glu Ser 
        195                 200                 205             


Leu Phe Ile Arg Ala Val Arg Ala Tyr Asn Gly Glu Asn Trp Arg Thr 
    210                 215                 220                 


Ser Ile Thr Asp Met Glu Leu Ala Leu Pro Asp Phe Phe Lys Ala Phe 
225                 230                 235                 240 


Tyr Glu Cys Leu Ala Ala Cys Glu Gly Ser Arg Glu Ile Lys Asp Phe 
                245                 250                 255     


Lys Asp Phe Tyr Leu Ser Ile Ala Asp His Tyr Val Glu Val Leu Glu 
            260                 265                 270         


Cys Lys Ile Gln Cys Glu Glu Asn Leu Thr Pro Val Ile Gly Gly Tyr 
        275                 280                 285             


Pro Val Glu Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala 
    290                 295                 300                 


Tyr Tyr Lys Leu Asn Asp Leu Lys Asn Ala Ala Pro Cys Ala Val Ser 
305                 310                 315                 320 


Tyr Leu Leu Phe Asp Gln Asn Asp Lys Val Met Gln Gln Asn Leu Val 
                325                 330                 335     


Tyr Tyr Gln Tyr His Arg Asp Thr Trp Gly Leu Ser Asp Glu His Phe 
            340                 345                 350         


Gln Pro Arg Pro Glu Ala Val Gln Phe Phe Asn Val Thr Thr Leu Gln 
        355                 360                 365             


Lys Glu Leu Tyr Asp Phe Ala Lys Glu Asn Ile Met Asp Asp Asp Glu 
    370                 375                 380                 


Gly Glu Val Val Glu Tyr Val Asp Asp Leu Leu Glu Leu Glu Glu Thr 
385                 390                 395                 400 


Ser 
    


<210> 65
<211> 2333
<212> DNA
<213> Homo sapiens

<400> 65
agtaggaccc aggggccggg aggcgccggc agagggaggg gccgggggcc ggggaggttt       60

tgagggaggt ctttggcttt ttttggcgga gctggggcgc cctccggaag cgtttccaac      120

tttccagaag tttctcggga cgggcaggag ggggtgggga ctgccatata tagatcccgg      180

gagcagggga gcgggctaag agtagaatcg tgtcgcggct cgagagcgag agtcacgtcc      240

cggcgctagc ccagcccgac ccagaatgaa aaaggcaggc attgacctcc ctctgaggca      300

gtttccaggc ccaccgtggt gcacgcaaac cacttcctgg ccatgcgctc cctcctgctt      360

ctcagcgcct tctgcctcct ggaggcggcc ctggccgccg aggtgaagaa acctgcagcc      420

gcagcagctc ctggcactgc ggagaagttg agccccaagg cggccacgct tgccgagcgc      480

agcgccggcc tggccttcag cttgtaccag gccatggcca aggaccaggc agtggagaac      540

atcctggtgt cacccgtggt ggtggcctcg tcgctagggc tcgtgtcgct gggcggcaag      600

gcgaccacgg cgtcgcaggc caaggcagtg ctgagcgccg agcagctgcg cgacgaggag      660

gtgcacgccg gcctgggcga gctgctgcgc tcactcagca actccacggc gcgcaacgtg      720

acctggaagc tgggcagccg actgtacgga cccagctcag tgagcttcgc tgatgacttc      780

gtgcgcagca gcaagcagca ctacaactgc gagcactcca agatcaactt ccgcgacaag      840

cgcagcgcgc tgcagtccat caacgagtgg gccgcgcaga ccaccgacgg caagctgccc      900

gaggtcacca aggacgtgga gcgcacggac ggcgccctgc tagtcaacgc catgttcttc      960

aagccacact gggatgagaa attccaccac aagatggtgg acaaccgtgg cttcatggtg     1020

actcggtcct ataccgtggg tgtcatgatg atgcaccgga caggcctcta caactactac     1080

gacgacgaga aggaaaagct gcaaatcgtg gagatgcccc tggcccacaa gctctccagc     1140

ctcatcatcc tcatgcccca tcacgtggag cctctcgagc gccttgaaaa gctgctaacc     1200

aaagagcagc tgaagatctg gatggggaag atgcagaaga aggctgttgc catctccttg     1260

cccaagggtg tggtggaggt gacccatgac ctgcagaaac acctggctgg gctgggcctg     1320

actgaggcca ttgacaagaa caaggccgac ttgtcacgca tgtcaggcaa gaaggacctg     1380

tacctggcca gcgtgttcca cgccaccgcc tttgagttgg acacagatgg caaccccttt     1440

gaccaggaca tctacgggcg cgaggagctg cgcagcccca agctgttcta cgccgaccac     1500

cccttcatct tcctagtgcg ggacacccaa agcggctccc tgctattcat tgggcgcctg     1560

gtccggccta agggtgacaa gatgcgagac gagttatagg gcctcagggt gcacacagga     1620

tggcaggagg catccaaagg ctcctgagac acatgggtgc tattggggtt gggggggagg     1680

tgaggtacca gccttggata ctccatgggg tgggggtgga aaaacagacc ggggttcccg     1740

tgtgcctgag cggaccttcc cagctagaat tcactccact tggacatggg ccccagatac     1800

catgatgctg agcccggaaa ctccacatcc tgtgggacct gggccatagt cattctgcct     1860

gccctgaaag tcccagatca agcctgcctc aatcagtatt catatttata gccaggtacc     1920

ttctcacctg tgagaccaaa ttgagctagg ggggtcagcc agccctcttc tgacactaaa     1980

acacctcagc tgcctcccca gctctatccc aacctctccc aactataaaa ctaggtgctg     2040

cagcccctgg gaccaggcac ccccagaatg acctggccgc agtgaggcgg attgagaagg     2100

agctcccagg aggggcttct gggcagactc tggtcaagaa gcatcgtgtc tggcgttgtg     2160

gggatgaact ttttgttttg tttcttcctt ttttagttct tcaaagatag ggagggaagg     2220

gggaacatga gcctttgttg ctatcaatcc aagaacttat ttgtacattt tttttttcaa     2280

taaaactttt ccaatgacat tttgttggag cgtggaagaa aaaaaaaaaa aaa            2333


<210> 66
<211> 418
<212> PRT
<213> Homo sapiens

<400> 66
Met Arg Ser Leu Leu Leu Leu Ser Ala Phe Cys Leu Leu Glu Ala Ala 
1               5                   10                  15      


Leu Ala Ala Glu Val Lys Lys Pro Ala Ala Ala Ala Ala Pro Gly Thr 
            20                  25                  30          


Ala Glu Lys Leu Ser Pro Lys Ala Ala Thr Leu Ala Glu Arg Ser Ala 
        35                  40                  45              


Gly Leu Ala Phe Ser Leu Tyr Gln Ala Met Ala Lys Asp Gln Ala Val 
    50                  55                  60                  


Glu Asn Ile Leu Val Ser Pro Val Val Val Ala Ser Ser Leu Gly Leu 
65                  70                  75                  80  


Val Ser Leu Gly Gly Lys Ala Thr Thr Ala Ser Gln Ala Lys Ala Val 
                85                  90                  95      


Leu Ser Ala Glu Gln Leu Arg Asp Glu Glu Val His Ala Gly Leu Gly 
            100                 105                 110         


Glu Leu Leu Arg Ser Leu Ser Asn Ser Thr Ala Arg Asn Val Thr Trp 
        115                 120                 125             


Lys Leu Gly Ser Arg Leu Tyr Gly Pro Ser Ser Val Ser Phe Ala Asp 
    130                 135                 140                 


Asp Phe Val Arg Ser Ser Lys Gln His Tyr Asn Cys Glu His Ser Lys 
145                 150                 155                 160 


Ile Asn Phe Arg Asp Lys Arg Ser Ala Leu Gln Ser Ile Asn Glu Trp 
                165                 170                 175     


Ala Ala Gln Thr Thr Asp Gly Lys Leu Pro Glu Val Thr Lys Asp Val 
            180                 185                 190         


Glu Arg Thr Asp Gly Ala Leu Leu Val Asn Ala Met Phe Phe Lys Pro 
        195                 200                 205             


His Trp Asp Glu Lys Phe His His Lys Met Val Asp Asn Arg Gly Phe 
    210                 215                 220                 


Met Val Thr Arg Ser Tyr Thr Val Gly Val Met Met Met His Arg Thr 
225                 230                 235                 240 


Gly Leu Tyr Asn Tyr Tyr Asp Asp Glu Lys Glu Lys Leu Gln Ile Val 
                245                 250                 255     


Glu Met Pro Leu Ala His Lys Leu Ser Ser Leu Ile Ile Leu Met Pro 
            260                 265                 270         


His His Val Glu Pro Leu Glu Arg Leu Glu Lys Leu Leu Thr Lys Glu 
        275                 280                 285             


Gln Leu Lys Ile Trp Met Gly Lys Met Gln Lys Lys Ala Val Ala Ile 
    290                 295                 300                 


Ser Leu Pro Lys Gly Val Val Glu Val Thr His Asp Leu Gln Lys His 
305                 310                 315                 320 


Leu Ala Gly Leu Gly Leu Thr Glu Ala Ile Asp Lys Asn Lys Ala Asp 
                325                 330                 335     


Leu Ser Arg Met Ser Gly Lys Lys Asp Leu Tyr Leu Ala Ser Val Phe 
            340                 345                 350         


His Ala Thr Ala Phe Glu Leu Asp Thr Asp Gly Asn Pro Phe Asp Gln 
        355                 360                 365             


Asp Ile Tyr Gly Arg Glu Glu Leu Arg Ser Pro Lys Leu Phe Tyr Ala 
    370                 375                 380                 


Asp His Pro Phe Ile Phe Leu Val Arg Asp Thr Gln Ser Gly Ser Leu 
385                 390                 395                 400 


Leu Phe Ile Gly Arg Leu Val Arg Pro Lys Gly Asp Lys Met Arg Asp 
                405                 410                 415     


Glu Leu 
        


<210> 67
<211> 3879
<212> DNA
<213> Homo sapiens

<400> 67
atcagacgcg cagaggaggc ggggccgcgg ctggtttcct gccggggggc ggctctgggc       60

cgccgagtcc cctcctcccg cccctgagga ggaggagccg ccgccacccg ccgcgcccga      120

cacccgggag gccccgccag cccgcgggag aggcccagcg ggagtcgcgg aacagcaggc      180

ccgagcccac cgcgccgggc cccggacgcc gcgcggaaaa gatgaattta caaccaattt      240

tctggattgg actgatcagt tcagtttgct gtgtgtttgc tcaaacagat gaaaatagat      300

gtttaaaagc aaatgccaaa tcatgtggag aatgtataca agcagggcca aattgtgggt      360

ggtgcacaaa ttcaacattt ttacaggaag gaatgcctac ttctgcacga tgtgatgatt      420

tagaagcctt aaaaaagaag ggttgccctc cagatgacat agaaaatccc agaggctcca      480

aagatataaa gaaaaataaa aatgtaacca accgtagcaa aggaacagca gagaagctca      540

agccagagga tattactcag atccaaccac agcagttggt tttgcgatta agatcagggg      600

agccacagac atttacatta aaattcaaga gagctgaaga ctatcccatt gacctctact      660

accttatgga cctgtcttac tcaatgaaag acgatttgga gaatgtaaaa agtcttggaa      720

cagatctgat gaatgaaatg aggaggatta cttcggactt cagaattgga tttggctcat      780

ttgtggaaaa gactgtgatg ccttacatta gcacaacacc agctaagctc aggaaccctt      840

gcacaagtga acagaactgc accagcccat ttagctacaa aaatgtgctc agtcttacta      900

ataaaggaga agtatttaat gaacttgttg gaaaacagcg catatctgga aatttggatt      960

ctccagaagg tggtttcgat gccatcatgc aagttgcagt ttgtggatca ctgattggct     1020

ggaggaatgt tacacggctg ctggtgtttt ccacagatgc cgggtttcac tttgctggag     1080

atgggaaact tggtggcatt gttttaccaa atgatggaca atgtcacctg gaaaataata     1140

tgtacacaat gagccattat tatgattatc cttctattgc tcaccttgtc cagaaactga     1200

gtgaaaataa tattcagaca atttttgcag ttactgaaga atttcagcct gtttacaagg     1260

agctgaaaaa cttgatccct aagtcagcag taggaacatt atctgcaaat tctagcaatg     1320

taattcagtt gatcattgat gcatacaatt ccctttcctc agaagtcatt ttggaaaacg     1380

gcaaattgtc agaaggcgta acaataagtt acaaatctta ctgcaagaac ggggtgaatg     1440

gaacagggga aaatggaaga aaatgttcca atatttccat tggagatgag gttcaatttg     1500

aaattagcat aacttcaaat aagtgtccaa aaaaggattc tgacagcttt aaaattaggc     1560

ctctgggctt tacggaggaa gtagaggtta ttcttcagta catctgtgaa tgtgaatgcc     1620

aaagcgaagg catccctgaa agtcccaagt gtcatgaagg aaatgggaca tttgagtgtg     1680

gcgcgtgcag gtgcaatgaa gggcgtgttg gtagacattg tgaatgcagc acagatgaag     1740

ttaacagtga agacatggat gcttactgca ggaaagaaaa cagttcagaa atctgcagta     1800

acaatggaga gtgcgtctgc ggacagtgtg tttgtaggaa gagggataat acaaatgaaa     1860

tttattctgg caaattctgc gagtgtgata atttcaactg tgatagatcc aatggcttaa     1920

tttgtggagg aaatggtgtt tgcaagtgtc gtgtgtgtga gtgcaacccc aactacactg     1980

gcagtgcatg tgactgttct ttggatacta gtacttgtga agccagcaac ggacagatct     2040

gcaatggccg gggcatctgc gagtgtggtg tctgtaagtg tacagatccg aagtttcaag     2100

ggcaaacgtg tgagatgtgt cagacctgcc ttggtgtctg tgctgagcat aaagaatgtg     2160

ttcagtgcag agccttcaat aaaggagaaa agaaagacac atgcacacag gaatgttcct     2220

attttaacat taccaaggta gaaagtcggg acaaattacc ccagccggtc caacctgatc     2280

ctgtgtccca ttgtaaggag aaggatgttg acgactgttg gttctatttt acgtattcag     2340

tgaatgggaa caacgaggtc atggttcatg ttgtggagaa tccagagtgt cccactggtc     2400

cagacatcat tccaattgta gctggtgtgg ttgctggaat tgttcttatt ggccttgcat     2460

tactgctgat atggaagctt ttaatgataa ttcatgacag aagggagttt gctaaatttg     2520

aaaaggagaa aatgaatgcc aaatgggaca cgggtgaaaa tcctatttat aagagtgccg     2580

taacaactgt ggtcaatccg aagtatgagg gaaaatgagt actgcccgtg caaatcccac     2640

aacactgaat gcaaagtagc aatttccata gtcacagtta ggtagcttta gggcaatatt     2700

gccatggttt tactcatgtg caggttttga aaatgtacaa tatgtataat ttttaaaatg     2760

ttttattatt ttgaaaataa tgttgtaatt catgccaggg actgacaaaa gacttgagac     2820

aggatggtta ctcttgtcag ctaaggtcac attgtgcctt tttgaccttt tcttcctgga     2880

ctattgaaat caagcttatt ggattaagtg atatttctat agcgattgaa agggcaatag     2940

ttaaagtaat gagcatgatg agagtttctg ttaatcatgt attaaaactg atttttagct     3000

ttacaaatat gtcagtttgc agttatgcag aatccaaagt aaatgtcctg ctagctagtt     3060

aaggattgtt ttaaatctgt tattttgcta tttgcctgtt agacatgact gatgacatat     3120

ctgaaagaca agtatgttga gagttgctgg tgtaaaatac gtttgaaata gttgatctac     3180

aaaggccatg ggaaaaattc agagagttag gaaggaaaaa ccaatagctt taaaacctgt     3240

gtgccatttt aagagttact taatgtttgg taacttttat gccttcactt tacaaattca     3300

agccttagat aaaagaaccg agcaattttc tgctaaaaag tccttgattt agcactattt     3360

acatacaggc catactttac aaagtatttg ctgaatgggg accttttgag ttgaatttat     3420

tttattattt ttattttgtt taatgtctgg tgctttctgt cacctcttct aatcttttaa     3480

tgtatttgtt tgcaattttg gggtaagact ttttttatga gtactttttc tttgaagttt     3540

tagcggtcaa tttgcctttt taatgaacat gtgaagttat actgtggcta tgcaacagct     3600

ctcacctacg cgagtcttac tttgagttag tgccataaca gaccactgta tgtttacttc     3660

tcaccatttg agttgcccat cttgtttcac actagtcaca ttcttgtttt aagtgccttt     3720

agttttaaca gttcactttt tacagtgcta tttactgaag ttatttatta aatatgccta     3780

aaatacttaa atcggatgtc ttgactctga tgtattttat caggttgtgt gcatgaaatt     3840

tttatagatt aaagaagttg aggaaaagca aaaaaaaaa                            3879


<210> 68
<211> 798
<212> PRT
<213> Homo sapiens

<400> 68
Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210> 69
<211> 2888
<212> DNA
<213> Homo sapiens

<400> 69
cccgagcctc tctccctggc caggccccag gtctcgcagc cagggatgga gatgggggga       60

gggggaacct agagttcttt gtagtgcctc cctcagactc taacacactc agcctggccc      120

cctcctccta ttgcaacccc ctcccccgct cctcccggcc aggccagctc agtcttccca      180

gcccccattc cacgtggacc agccagggcg ggggtaggga aagaggacag gaagaggggg      240

agccagttct gggaggcggg gggaaggagg ttggtggcga ctccctcgct cgccctcact      300

gccggcggtc ccaactccag gcaccatgtt ccccgcgggc ccccccagcc acagcctcct      360

ccggctcccc ctgctgcagt tgctgctact ggtggtgcag gccgtgggga gggggctggg      420

ccgcgccagc ccggccgggg gccccctgga agatgtggtc atcgagaggt accacatccc      480

cagggcctgt ccccgggaag tgcagatggg ggattttgtg cgctaccact acaacggcac      540

ttttgaagat ggcaagaagt ttgattcaag ctatgatcgc aacaccttgg tggccatcgt      600

ggtgggtgtg gggcgcctca tcactggcat ggaccgaggc ctcatgggca tgtgtgtcaa      660

cgagcggcga cgcctcattg tgcctcccca cctgggctat gggagcatcg gcctggcggg      720

gctcattcca ccggatgcca ccctctactt cgatgtggtt ctgctggatg tgtggaacaa      780

ggaagacacc gtgcaggtga gcacattgct gcgcccgccc cactgccccc gcatggtcca      840

ggacggcgac tttgtccgct accactacaa tggcaccctg ctggacggca cctccttcga      900

caccagctac agtaagggcg gcacttatga cacctacgtc ggctctggtt ggctgatcaa      960

gggcatggac caggggctgc tgggcatgtg tcctggagag agaaggaaga ttatcatccc     1020

tccattcctg gcctatggcg agaaaggcta tgggacagtg atccccccac aggcctcgct     1080

ggtctttcac gtcctcctga ttgacgtgca caacccgaag gacgctgtcc agctagagac     1140

gctggagctc ccccccggct gtgtccgcag agccggggcc ggggacttca tgcgctacca     1200

ctacaatggc tccttgatgg acggcaccct cttcgattcc agctactccc gcaaccacac     1260

ctacaatacc tatatcgggc agggttacat catccccggg atggaccagg ggctgcaggg     1320

tgcctgcatg ggggaacgcc ggagaattac catccccccg cacctcgcct atggggagaa     1380

tggaactgga gacaagatcc ctggctctgc cgtgctaatc ttcaacgtcc atgtcattga     1440

cttccacaac cctgcggatg tggtggaaat caggacactg tcccggccat ctgagacctg     1500

caatgagacc accaagcttg gggactttgt tcgataccat tacaactgtt ctttgctgga     1560

cggcacccag ctgttcacct cgcatgacta cggggccccc caggaggcga ctctcggggc     1620

caacaaggtg atcgaaggcc tggacacggg cctgcagggc atgtgtgtgg gagagaggcg     1680

gcagctcatc gtgcccccgc acctggccca cggggagagt ggagcccggg gagtcccagg     1740

cagtgctgtg ctgctgtttg aggtggagct ggtgtcccgg gaggatgggc tgcccacagg     1800

ctacctgttt gtgtggcaca aggaccctcc tgccaacctg tttgaagaca tggacctcaa     1860

caaggatggc gaggtccctc cggaggagtt ctccaccttc atcaaggctc aagtgagtga     1920

gggcaaagga cgcctcatgc ctgggcagga ccctgagaaa accataggag acatgttcca     1980

gaaccaggac cgcaaccagg acggcaagat cacagtcgac gagctcaagc tgaagtcaga     2040

tgaggacgag gagcgggtcc acgaggagct ctgaggggca gggagcctgg ccaggcctga     2100

gacacagagg cccactgcga gggggacagt ggcggtggga ctgacctgct gacagtcacc     2160

ctccctctgc tgggatgagg tccaggagcc aactaaaaca atggcagagg agacatctct     2220

ggtgttccca ccaccctaga tgaaaatcca cagcacagac ctctaccgtg tttctcttcc     2280

atccctaaac cacttcctta aaatgtttgg atttgcaaag ccaatttggg gcctgtggag     2340

cctggggttg gatagggcca tggctggtcc cccaccatac ctcccctcca catcactgac     2400

acagctgagc ttgttatcca tctccccaaa ctttctcttt ctttgtactt cttgtcatcc     2460

ccactcccag ccccttttcc tctatgtgac agctccctag gacccctctg ccttcctccc     2520

caatcctgac tggctcctag ggaaggggaa ggctcctgga gggcagccct acctctccca     2580

tgccctttgc cctcctccct cgcctccagt ggaggctgag ctgaccctgg gctgctggag     2640

gccagactgg gctgtagtta gcttttcatc cctaaagaag gctcctttcc ctaaggaacc     2700

atagaagaga ggaagaaaac aaagggcatg tgtgagggaa gctgcttggg tgggtgttag     2760

ggctatgaaa tcttggattt ggggctgagg ggtgggaggg agggcagagc tctgcacact     2820

caaaggctaa actggtgtca gtcctttttt cctttgttcc aaataaaaga ttaaaccaat     2880

ggcaaaaa                                                              2888


<210> 70
<211> 582
<212> PRT
<213> Homo sapiens

<400> 70
Met Phe Pro Ala Gly Pro Pro Ser His Ser Leu Leu Arg Leu Pro Leu 
1               5                   10                  15      


Leu Gln Leu Leu Leu Leu Val Val Gln Ala Val Gly Arg Gly Leu Gly 
            20                  25                  30          


Arg Ala Ser Pro Ala Gly Gly Pro Leu Glu Asp Val Val Ile Glu Arg 
        35                  40                  45              


Tyr His Ile Pro Arg Ala Cys Pro Arg Glu Val Gln Met Gly Asp Phe 
    50                  55                  60                  


Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly Lys Lys Phe Asp 
65                  70                  75                  80  


Ser Ser Tyr Asp Arg Asn Thr Leu Val Ala Ile Val Val Gly Val Gly 
                85                  90                  95      


Arg Leu Ile Thr Gly Met Asp Arg Gly Leu Met Gly Met Cys Val Asn 
            100                 105                 110         


Glu Arg Arg Arg Leu Ile Val Pro Pro His Leu Gly Tyr Gly Ser Ile 
        115                 120                 125             


Gly Leu Ala Gly Leu Ile Pro Pro Asp Ala Thr Leu Tyr Phe Asp Val 
    130                 135                 140                 


Val Leu Leu Asp Val Trp Asn Lys Glu Asp Thr Val Gln Val Ser Thr 
145                 150                 155                 160 


Leu Leu Arg Pro Pro His Cys Pro Arg Met Val Gln Asp Gly Asp Phe 
                165                 170                 175     


Val Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Ser Phe Asp 
            180                 185                 190         


Thr Ser Tyr Ser Lys Gly Gly Thr Tyr Asp Thr Tyr Val Gly Ser Gly 
        195                 200                 205             


Trp Leu Ile Lys Gly Met Asp Gln Gly Leu Leu Gly Met Cys Pro Gly 
    210                 215                 220                 


Glu Arg Arg Lys Ile Ile Ile Pro Pro Phe Leu Ala Tyr Gly Glu Lys 
225                 230                 235                 240 


Gly Tyr Gly Thr Val Ile Pro Pro Gln Ala Ser Leu Val Phe His Val 
                245                 250                 255     


Leu Leu Ile Asp Val His Asn Pro Lys Asp Ala Val Gln Leu Glu Thr 
            260                 265                 270         


Leu Glu Leu Pro Pro Gly Cys Val Arg Arg Ala Gly Ala Gly Asp Phe 
        275                 280                 285             


Met Arg Tyr His Tyr Asn Gly Ser Leu Met Asp Gly Thr Leu Phe Asp 
    290                 295                 300                 


Ser Ser Tyr Ser Arg Asn His Thr Tyr Asn Thr Tyr Ile Gly Gln Gly 
305                 310                 315                 320 


Tyr Ile Ile Pro Gly Met Asp Gln Gly Leu Gln Gly Ala Cys Met Gly 
                325                 330                 335     


Glu Arg Arg Arg Ile Thr Ile Pro Pro His Leu Ala Tyr Gly Glu Asn 
            340                 345                 350         


Gly Thr Gly Asp Lys Ile Pro Gly Ser Ala Val Leu Ile Phe Asn Val 
        355                 360                 365             


His Val Ile Asp Phe His Asn Pro Ala Asp Val Val Glu Ile Arg Thr 
    370                 375                 380                 


Leu Ser Arg Pro Ser Glu Thr Cys Asn Glu Thr Thr Lys Leu Gly Asp 
385                 390                 395                 400 


Phe Val Arg Tyr His Tyr Asn Cys Ser Leu Leu Asp Gly Thr Gln Leu 
                405                 410                 415     


Phe Thr Ser His Asp Tyr Gly Ala Pro Gln Glu Ala Thr Leu Gly Ala 
            420                 425                 430         


Asn Lys Val Ile Glu Gly Leu Asp Thr Gly Leu Gln Gly Met Cys Val 
        435                 440                 445             


Gly Glu Arg Arg Gln Leu Ile Val Pro Pro His Leu Ala His Gly Glu 
    450                 455                 460                 


Ser Gly Ala Arg Gly Val Pro Gly Ser Ala Val Leu Leu Phe Glu Val 
465                 470                 475                 480 


Glu Leu Val Ser Arg Glu Asp Gly Leu Pro Thr Gly Tyr Leu Phe Val 
                485                 490                 495     


Trp His Lys Asp Pro Pro Ala Asn Leu Phe Glu Asp Met Asp Leu Asn 
            500                 505                 510         


Lys Asp Gly Glu Val Pro Pro Glu Glu Phe Ser Thr Phe Ile Lys Ala 
        515                 520                 525             


Gln Val Ser Glu Gly Lys Gly Arg Leu Met Pro Gly Gln Asp Pro Glu 
    530                 535                 540                 


Lys Thr Ile Gly Asp Met Phe Gln Asn Gln Asp Arg Asn Gln Asp Gly 
545                 550                 555                 560 


Lys Ile Thr Val Asp Glu Leu Lys Leu Lys Ser Asp Glu Asp Glu Glu 
                565                 570                 575     


Arg Val His Glu Glu Leu 
            580         


<210> 71
<211> 8449
<212> DNA
<213> Homo sapiens

<400> 71
gcccgcgccg gctgtgctgc acagggggag gagagggaac cccaggcgcg agcgggaaga       60

ggggacctgc agccacaact tctctggtcc tctgcatccc ttctgtccct ccacccgtcc      120

ccttccccac cctctggccc ccaccttctt ggaggcgaca acccccggga ggcattagaa      180

gggatttttc ccgcaggttg cgaagggaag caaacttggt ggcaacttgc ctcccggtgc      240

gggcgtctct cccccaccgt ctcaacatgc ttaggggtcc ggggcccggg ctgctgctgc      300

tggccgtcca gtgcctgggg acagcggtgc cctccacggg agcctcgaag agcaagaggc      360

aggctcagca aatggttcag ccccagtccc cggtggctgt cagtcaaagc aagcccggtt      420

gttatgacaa tggaaaacac tatcagataa atcaacagtg ggagcggacc tacctaggca      480

atgcgttggt ttgtacttgt tatggaggaa gccgaggttt taactgcgag agtaaacctg      540

aagctgaaga gacttgcttt gacaagtaca ctgggaacac ttaccgagtg ggtgacactt      600

atgagcgtcc taaagactcc atgatctggg actgtacctg catcggggct gggcgaggga      660

gaataagctg taccatcgca aaccgctgcc atgaaggggg tcagtcctac aagattggtg      720

acacctggag gagaccacat gagactggtg gttacatgtt agagtgtgtg tgtcttggta      780

atggaaaagg agaatggacc tgcaagccca tagctgagaa gtgttttgat catgctgctg      840

ggacttccta tgtggtcgga gaaacgtggg agaagcccta ccaaggctgg atgatggtag      900

attgtacttg cctgggagaa ggcagcggac gcatcacttg cacttctaga aatagatgca      960

acgatcagga cacaaggaca tcctatagaa ttggagacac ctggagcaag aaggataatc     1020

gaggaaacct gctccagtgc atctgcacag gcaacggccg aggagagtgg aagtgtgaga     1080

ggcacacctc tgtgcagacc acatcgagcg gatctggccc cttcaccgat gttcgtgcag     1140

ctgtttacca accgcagcct cacccccagc ctcctcccta tggccactgt gtcacagaca     1200

gtggtgtggt ctactctgtg gggatgcagt ggctgaagac acaaggaaat aagcaaatgc     1260

tttgcacgtg cctgggcaac ggagtcagct gccaagagac agctgtaacc cagacttacg     1320

gtggcaactc aaatggagag ccatgtgtct taccattcac ctacaatggc aggacgttct     1380

actcctgcac cacagaaggg cgacaggacg gacatctttg gtgcagcaca acttcgaatt     1440

atgagcagga ccagaaatac tctttctgca cagaccacac tgttttggtt cagactcgag     1500

gaggaaattc caatggtgcc ttgtgccact tccccttcct atacaacaac cacaattaca     1560

ctgattgcac ttctgagggc agaagagaca acatgaagtg gtgtgggacc acacagaact     1620

atgatgccga ccagaagttt gggttctgcc ccatggctgc ccacgaggaa atctgcacaa     1680

ccaatgaagg ggtcatgtac cgcattggag atcagtggga taagcagcat gacatgggtc     1740

acatgatgag gtgcacgtgt gttgggaatg gtcgtgggga atggacatgc attgcctact     1800

cgcagcttcg agatcagtgc attgttgatg acatcactta caatgtgaac gacacattcc     1860

acaagcgtca tgaagagggg cacatgctga actgtacatg cttcggtcag ggtcggggca     1920

ggtggaagtg tgatcccgtc gaccaatgcc aggattcaga gactgggacg ttttatcaaa     1980

ttggagattc atgggagaag tatgtgcatg gtgtcagata ccagtgctac tgctatggcc     2040

gtggcattgg ggagtggcat tgccaacctt tacagaccta tccaagctca agtggtcctg     2100

tcgaagtatt tatcactgag actccgagtc agcccaactc ccaccccatc cagtggaatg     2160

caccacagcc atctcacatt tccaagtaca ttctcaggtg gagacctaaa aattctgtag     2220

gccgttggaa ggaagctacc ataccaggcc acttaaactc ctacaccatc aaaggcctga     2280

agcctggtgt ggtatacgag ggccagctca tcagcatcca gcagtacggc caccaagaag     2340

tgactcgctt tgacttcacc accaccagca ccagcacacc tgtgaccagc aacaccgtga     2400

caggagagac gactcccttt tctcctcttg tggccacttc tgaatctgtg accgaaatca     2460

cagccagtag ctttgtggtc tcctgggtct cagcttccga caccgtgtcg ggattccggg     2520

tggaatatga gctgagtgag gagggagatg agccacagta cctggatctt ccaagcacag     2580

ccacttctgt gaacatccct gacctgcttc ctggccgaaa atacattgta aatgtctatc     2640

agatatctga ggatggggag cagagtttga tcctgtctac ttcacaaaca acagcgcctg     2700

atgcccctcc tgacccgact gtggaccaag ttgatgacac ctcaattgtt gttcgctgga     2760

gcagacccca ggctcccatc acagggtaca gaatagtcta ttcgccatca gtagaaggta     2820

gcagcacaga actcaacctt cctgaaactg caaactccgt caccctcagt gacttgcaac     2880

ctggtgttca gtataacatc actatctatg ctgtggaaga aaatcaagaa agtacacctg     2940

ttgtcattca acaagaaacc actggcaccc cacgctcaga tacagtgccc tctcccaggg     3000

acctgcagtt tgtggaagtg acagacgtga aggtcaccat catgtggaca ccgcctgaga     3060

gtgcagtgac cggctaccgt gtggatgtga tccccgtcaa cctgcctggc gagcacgggc     3120

agaggctgcc catcagcagg aacacctttg cagaagtcac cgggctgtcc cctggggtca     3180

cctattactt caaagtcttt gcagtgagcc atgggaggga gagcaagcct ctgactgctc     3240

aacagacaac caaactggat gctcccacta acctccagtt tgtcaatgaa actgattcta     3300

ctgtcctggt gagatggact ccacctcggg cccagataac aggataccga ctgaccgtgg     3360

gccttacccg aagaggacag cccaggcagt acaatgtggg tccctctgtc tccaagtacc     3420

cactgaggaa tctgcagcct gcatctgagt acaccgtatc cctcgtggcc ataaagggca     3480

accaagagag ccccaaagcc actggagtct ttaccacact gcagcctggg agctctattc     3540

caccttacaa caccgaggtg actgagacca ccattgtgat cacatggacg cctgctccaa     3600

gaattggttt taagctgggt gtacgaccaa gccagggagg agaggcacca cgagaagtga     3660

cttcagactc aggaagcatc gttgtgtccg gcttgactcc aggagtagaa tacgtctaca     3720

ccatccaagt cctgagagat ggacaggaaa gagatgcgcc aattgtaaac aaagtggtga     3780

caccattgtc tccaccaaca aacttgcatc tggaggcaaa ccctgacact ggagtgctca     3840

cagtctcctg ggagaggagc accaccccag acattactgg ttatagaatt accacaaccc     3900

ctacaaacgg ccagcaggga aattctttgg aagaagtggt ccatgctgat cagagctcct     3960

gcacttttga taacctgagt cccggcctgg agtacaatgt cagtgtttac actgtcaagg     4020

atgacaagga aagtgtccct atctctgata ccatcatccc agctgttcct cctcccactg     4080

acctgcgatt caccaacatt ggtccagaca ccatgcgtgt cacctgggct ccacccccat     4140

ccattgattt aaccaacttc ctggtgcgtt actcacctgt gaaaaatgag gaagatgttg     4200

cagagttgtc aatttctcct tcagacaatg cagtggtctt aacaaatctc ctgcctggta     4260

cagaatatgt agtgagtgtc tccagtgtct acgaacaaca tgagagcaca cctcttagag     4320

gaagacagaa aacaggtctt gattccccaa ctggcattga cttttctgat attactgcca     4380

actcttttac tgtgcactgg attgctcctc gagccaccat cactggctac aggatccgcc     4440

atcatcccga gcacttcagt gggagacctc gagaagatcg ggtgccccac tctcggaatt     4500

ccatcaccct caccaacctc actccaggca cagagtatgt ggtcagcatc gttgctctta     4560

atggcagaga ggaaagtccc ttattgattg gccaacaatc aacagtttct gatgttccga     4620

gggacctgga agttgttgct gcgaccccca ccagcctact gatcagctgg gatgctcctg     4680

ctgtcacagt gagatattac aggatcactt acggagagac aggaggaaat agccctgtcc     4740

aggagttcac tgtgcctggg agcaagtcta cagctaccat cagcggcctt aaacctggag     4800

ttgattatac catcactgtg tatgctgtca ctggccgtgg agacagcccc gcaagcagca     4860

agccaatttc cattaattac cgaacagaaa ttgacaaacc atcccagatg caagtgaccg     4920

atgttcagga caacagcatt agtgtcaagt ggctgccttc aagttcccct gttactggtt     4980

acagagtaac caccactccc aaaaatggac caggaccaac aaaaactaaa actgcaggtc     5040

cagatcaaac agaaatgact attgaaggct tgcagcccac agtggagtat gtggttagtg     5100

tctatgctca gaatccaagc ggagagagtc agcctctggt tcagactgca gtaaccaaca     5160

ttgatcgccc taaaggactg gcattcactg atgtggatgt cgattccatc aaaattgctt     5220

gggaaagccc acaggggcaa gtttccaggt acagggtgac ctactcgagc cctgaggatg     5280

gaatccatga gctattccct gcacctgatg gtgaagaaga cactgcagag ctgcaaggcc     5340

tcagaccggg ttctgagtac acagtcagtg tggttgcctt gcacgatgat atggagagcc     5400

agcccctgat tggaacccag tccacagcta ttcctgcacc aactgacctg aagttcactc     5460

aggtcacacc cacaagcctg agcgcccagt ggacaccacc caatgttcag ctcactggat     5520

atcgagtgcg ggtgaccccc aaggagaaga ccggaccaat gaaagaaatc aaccttgctc     5580

ctgacagctc atccgtggtt gtatcaggac ttatggtggc caccaaatat gaagtgagtg     5640

tctatgctct taaggacact ttgacaagca gaccagctca gggagttgtc accactctgg     5700

agaatgtcag cccaccaaga agggctcgtg tgacagatgc tactgagacc accatcacca     5760

ttagctggag aaccaagact gagacgatca ctggcttcca agttgatgcc gttccagcca     5820

atggccagac tccaatccag agaaccatca agccagatgt cagaagctac accatcacag     5880

gtttacaacc aggcactgac tacaagatct acctgtacac cttgaatgac aatgctcgga     5940

gctcccctgt ggtcatcgac gcctccactg ccattgatgc accatccaac ctgcgtttcc     6000

tggccaccac acccaattcc ttgctggtat catggcagcc gccacgtgcc aggattaccg     6060

gctacatcat caagtatgag aagcctgggt ctcctcccag agaagtggtc cctcggcccc     6120

gccctggtgt cacagaggct actattactg gcctggaacc gggaaccgaa tatacaattt     6180

atgtcattgc cctgaagaat aatcagaaga gcgagcccct gattggaagg aaaaagacag     6240

acgagcttcc ccaactggta acccttccac accccaatct tcatggacca gagatcttgg     6300

atgttccttc cacagttcaa aagacccctt tcgtcaccca ccctgggtat gacactggaa     6360

atggtattca gcttcctggc acttctggtc agcaacccag tgttgggcaa caaatgatct     6420

ttgaggaaca tggttttagg cggaccacac cgcccacaac ggccaccccc ataaggcata     6480

ggccaagacc atacccgccg aatgtaggac aagaagctct ctctcagaca accatctcat     6540

gggccccatt ccaggacact tctgagtaca tcatttcatg tcatcctgtt ggcactgatg     6600

aagaaccctt acagttcagg gttcctggaa cttctaccag tgccactctg acaggcctca     6660

ccagaggtgc cacctacaac atcatagtgg aggcactgaa agaccagcag aggcataagg     6720

ttcgggaaga ggttgttacc gtgggcaact ctgtcaacga aggcttgaac caacctacgg     6780

atgactcgtg ctttgacccc tacacagttt cccattatgc cgttggagat gagtgggaac     6840

gaatgtctga atcaggcttt aaactgttgt gccagtgctt aggctttgga agtggtcatt     6900

tcagatgtga ttcatctaga tggtgccatg acaatggtgt gaactacaag attggagaga     6960

agtgggaccg tcagggagaa aatggccaga tgatgagctg cacatgtctt gggaacggaa     7020

aaggagaatt caagtgtgac cctcatgagg caacgtgtta tgatgatggg aagacatacc     7080

acgtaggaga acagtggcag aaggaatatc tcggtgccat ttgctcctgc acatgctttg     7140

gaggccagcg gggctggcgc tgtgacaact gccgcagacc tgggggtgaa cccagtcccg     7200

aaggcactac tggccagtcc tacaaccagt attctcagag ataccatcag agaacaaaca     7260

ctaatgttaa ttgcccaatt gagtgcttca tgcctttaga tgtacaggct gacagagaag     7320

attcccgaga gtaaatcatc tttccaatcc agaggaacaa gcatgtctct ctgccaagat     7380

ccatctaaac tggagtgatg ttagcagacc cagcttagag ttcttctttc tttcttaagc     7440

cctttgctct ggaggaagtt ctccagcttc agctcaactc acagcttctc caagcatcac     7500

cctgggagtt tcctgagggt tttctcataa atgagggctg cacattgcct gttctgcttc     7560

gaagtattca ataccgctca gtattttaaa tgaagtgatt ctaagatttg gtttgggatc     7620

aataggaaag catatgcagc caaccaagat gcaaatgttt tgaaatgata tgaccaaaat     7680

tttaagtagg aaagtcaccc aaacacttct gctttcactt aagtgtctgg cccgcaatac     7740

tgtaggaaca agcatgatct tgttactgtg atattttaaa tatccacagt actcactttt     7800

tccaaatgat cctagtaatt gcctagaaat atctttctct tacctgttat ttatcaattt     7860

ttcccagtat ttttatacgg aaaaaattgt attgaaaaca cttagtatgc agttgataag     7920

aggaatttgg tataattatg gtgggtgatt attttttata ctgtatgtgc caaagcttta     7980

ctactgtgga aagacaactg ttttaataaa agatttacat tccacaactt gaagttcatc     8040

tatttgatat aagacacctt cgggggaaat aattcctgtg aatattcttt ttcaattcag     8100

caaacatttg aaaatctatg atgtgcaagt ctaattgttg atttcagtac aagattttct     8160

aaatcagttg ctacaaaaac tgattggttt ttgtcacttc atctcttcac taatggagat     8220

agctttacac tttctgcttt aatagattta agtggacccc aatatttatt aaaattgcta     8280

gtttaccgtt cagaagtata atagaaataa tctttagttg ctcttttcta accattgtaa     8340

ttcttccctt cttccctcca cctttccttc attgaataaa cctctgttca aagagattgc     8400

ctgcaaggga aataaaaatg actaagatat taaaaaaaaa aaaaaaaaa                 8449


<210> 72
<211> 2355
<212> PRT
<213> Homo sapiens

<400> 72
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1985                 1990                 1995             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2000                 2005                 2010             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2015                 2020                 2025             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2030                 2035                 2040             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2045                 2050                 2055             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2060                 2065                 2070             


Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu Ala Leu  Ser Gln Thr 
    2075                 2080                 2085             


Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr Ser Glu  Tyr Ile Ile 
    2090                 2095                 2100             


Ser Cys  His Pro Val Gly Thr  Asp Glu Glu Pro Leu  Gln Phe Arg 
    2105                 2110                 2115             


Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu Thr Gly  Leu Thr Arg 
    2120                 2125                 2130             


Gly Ala  Thr Tyr Asn Ile Ile  Val Glu Ala Leu Lys  Asp Gln Gln 
    2135                 2140                 2145             


Arg His  Lys Val Arg Glu Glu  Val Val Thr Val Gly  Asn Ser Val 
    2150                 2155                 2160             


Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp Ser Cys  Phe Asp Pro 
    2165                 2170                 2175             


Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp Glu Trp  Glu Arg Met 
    2180                 2185                 2190             


Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln Cys Leu  Gly Phe Gly 
    2195                 2200                 2205             


Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg Trp Cys  His Asp Asn 
    2210                 2215                 2220             


Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp Asp Arg  Gln Gly Glu 
    2225                 2230                 2235             


Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu Gly Asn  Gly Lys Gly 
    2240                 2245                 2250             


Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr Cys Tyr  Asp Asp Gly 
    2255                 2260                 2265             


Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln Lys Glu  Tyr Leu Gly 
    2270                 2275                 2280             


Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly Gln Arg  Gly Trp Arg 
    2285                 2290                 2295             


Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu Pro Ser  Pro Glu Gly 
    2300                 2305                 2310             


Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser Gln Arg  Tyr His Gln 
    2315                 2320                 2325             


Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile Glu Cys  Phe Met Pro 
    2330                 2335                 2340             


Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser Arg Glu  
    2345                 2350                 2355 


<210> 73
<211> 850
<212> DNA
<213> Homo sapiens

<400> 73
gcgccccgcc cctgagccgg ccgcccagcc cccagtgggg ttcccggcgc ggggaatgtc       60

ccgggtggag ctggctgagt cgcgcgctct gctccacccg acggggctgt gtgtgctggg      120

cctggctcgc ggcgaaccga gatggcagag cagtcggacg aggccgtgaa gtactacacc      180

ctagaggaga ttcagaagca caaccacagc aagagcacct ggctgatcct gcaccacaag      240

gtgtacgatt tgaccaaatt tctggaagag catcctggtg gggaagaagt tttaagggaa      300

caagctggag gtgacgctac tgagaacttt gaggatgtcg ggcactctac agatgccagg      360

gaaatgtcca aaacattcat cattggggag ctccatccag atgacagacc aaagttaaac      420

aagcctccgg aaactcttat cactactatt gattctagtt ccagttggtg gaccaactgg      480

gtgatccctg ccatctctgc agtggccgtc gccttgatgt atcgcctata catggcagag      540

gactgaacac ctcctcagaa gtcagcgcag gaagagcctg ctttggacac gggagaaaag      600

aagccattgc taactacttc aactgacaga aaccttcact tgaaaacaat gattttaata      660

tatctctttc tttttcttcc gacattagaa acaaaacaaa aagaactgtc ctttctgcgc      720

tcaaattttt cgagtgtgcc tttttattca tctactttat tttgatgttt ccttaatgtg      780

taatttactt attataagca tgatctttta aaaatatatt tggcttttaa agtatgcaaa      840

aaaaaaaaaa                                                             850


<210> 74
<211> 134
<212> PRT
<213> Homo sapiens

<400> 74
Met Ala Glu Gln Ser Asp Glu Ala Val Lys Tyr Tyr Thr Leu Glu Glu 
1               5                   10                  15      


Ile Gln Lys His Asn His Ser Lys Ser Thr Trp Leu Ile Leu His His 
            20                  25                  30          


Lys Val Tyr Asp Leu Thr Lys Phe Leu Glu Glu His Pro Gly Gly Glu 
        35                  40                  45              


Glu Val Leu Arg Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu 
    50                  55                  60                  


Asp Val Gly His Ser Thr Asp Ala Arg Glu Met Ser Lys Thr Phe Ile 
65                  70                  75                  80  


Ile Gly Glu Leu His Pro Asp Asp Arg Pro Lys Leu Asn Lys Pro Pro 
                85                  90                  95      


Glu Thr Leu Ile Thr Thr Ile Asp Ser Ser Ser Ser Trp Trp Thr Asn 
            100                 105                 110         


Trp Val Ile Pro Ala Ile Ser Ala Val Ala Val Ala Leu Met Tyr Arg 
        115                 120                 125             


Leu Tyr Met Ala Glu Asp 
    130                 


<210> 75
<211> 874
<212> DNA
<213> Homo sapiens

<400> 75
gcgccccgcc cctgagccgg ccgcccagcc cccagtgggg ttcccggcgc ggggaatgtc       60

ccgggtggag ctggctgagt cgcgcgctct gctccacccg acggggctgt gtgtgctggg      120

cctggctcgc ggcgaaccga gatggcagag cagtcggacg aggccgtgaa gtactacacc      180

ctagaggaga ttcagaagca caaccacagc aagagcacct ggctgatcct gcaccacaag      240

gtgtacgatt tgaccaaatt tctggaagag catcctggtg gggaagaagt tttaagggaa      300

caagctggag gtgacgctac tgagaacttt gaggatgtcg ggcactctac agatgccagg      360

gaaatgtcca aaacattcat cattggggag ctccatccag atgacagacc aaagttaaac      420

aagcctccgg aaccttaaag gcggtgtttc aaggaaactc ttatcactac tattgattct      480

agttccagtt ggtggaccaa ctgggtgatc cctgccatct ctgcagtggc cgtcgccttg      540

atgtatcgcc tatacatggc agaggactga acacctcctc agaagtcagc gcaggaagag      600

cctgctttgg acacgggaga aaagaagcca ttgctaacta cttcaactga cagaaacctt      660

cacttgaaaa caatgatttt aatatatctc tttctttttc ttccgacatt agaaacaaaa      720

caaaaagaac tgtcctttct gcgctcaaat ttttcgagtg tgccttttta ttcatctact      780

ttattttgat gtttccttaa tgtgtaattt acttattata agcatgatct tttaaaaata      840

tatttggctt ttaaagtatg caaaaaaaaa aaaa                                  874


<210> 76
<211> 98
<212> PRT
<213> Homo sapiens

<400> 76
Met Ala Glu Gln Ser Asp Glu Ala Val Lys Tyr Tyr Thr Leu Glu Glu 
1               5                   10                  15      


Ile Gln Lys His Asn His Ser Lys Ser Thr Trp Leu Ile Leu His His 
            20                  25                  30          


Lys Val Tyr Asp Leu Thr Lys Phe Leu Glu Glu His Pro Gly Gly Glu 
        35                  40                  45              


Glu Val Leu Arg Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu 
    50                  55                  60                  


Asp Val Gly His Ser Thr Asp Ala Arg Glu Met Ser Lys Thr Phe Ile 
65                  70                  75                  80  


Ile Gly Glu Leu His Pro Asp Asp Arg Pro Lys Leu Asn Lys Pro Pro 
                85                  90                  95      


Glu Pro 
        


<210> 77
<211> 820
<212> DNA
<213> Homo sapiens

<400> 77
gcgccccgcc cctgagccgg ccgcccagcc cccagtgggg ttcccggcgc ggggaatgtc       60

ccgggtggag ctggctgagt cgcgcgctct gctccacccg acggggctgt gtgtgctggg      120

cctggctcgc ggcgaaccga gatggcagag cagtcggacg aggccgtgaa gtactacacc      180

ctagaggaga ttcagaagca caaccacagc aagagcacct ggctgatcct gcaccacaag      240

gtgtacgatt tgaccaaatt tctggaagag catcctggtg gggaagaagt tttaagggaa      300

caagctggag gtgacgctac tgagaacttt gaggatgtcg ggcactctac agatgccagg      360

gaaatgtcca aaacattcat cattggggag ctccatccag aaactcttat cactactatt      420

gattctagtt ccagttggtg gaccaactgg gtgatccctg ccatctctgc agtggccgtc      480

gccttgatgt atcgcctata catggcagag gactgaacac ctcctcagaa gtcagcgcag      540

gaagagcctg ctttggacac gggagaaaag aagccattgc taactacttc aactgacaga      600

aaccttcact tgaaaacaat gattttaata tatctctttc tttttcttcc gacattagaa      660

acaaaacaaa aagaactgtc ctttctgcgc tcaaattttt cgagtgtgcc tttttattca      720

tctactttat tttgatgttt ccttaatgtg taatttactt attataagca tgatctttta      780

aaaatatatt tggcttttaa agtatgcaaa aaaaaaaaaa                            820


<210> 78
<211> 124
<212> PRT
<213> Homo sapiens

<400> 78
Met Ala Glu Gln Ser Asp Glu Ala Val Lys Tyr Tyr Thr Leu Glu Glu 
1               5                   10                  15      


Ile Gln Lys His Asn His Ser Lys Ser Thr Trp Leu Ile Leu His His 
            20                  25                  30          


Lys Val Tyr Asp Leu Thr Lys Phe Leu Glu Glu His Pro Gly Gly Glu 
        35                  40                  45              


Glu Val Leu Arg Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu 
    50                  55                  60                  


Asp Val Gly His Ser Thr Asp Ala Arg Glu Met Ser Lys Thr Phe Ile 
65                  70                  75                  80  


Ile Gly Glu Leu His Pro Glu Thr Leu Ile Thr Thr Ile Asp Ser Ser 
                85                  90                  95      


Ser Ser Trp Trp Thr Asn Trp Val Ile Pro Ala Ile Ser Ala Val Ala 
            100                 105                 110         


Val Ala Leu Met Tyr Arg Leu Tyr Met Ala Glu Asp 
        115                 120                 


<210> 79
<211> 3207
<212> DNA
<213> Homo sapiens

<400> 79
ggcccacaga ggagcacagc tgtgtttggc tgcagggcca agagcgctgt caagaagacc       60

cacacgcccc cctccagcag ctgaattcct gcagctcagc agccgccgcc agagcaggac      120

gaaccgccaa tcgcaaggca cctctgagaa cttcaggatg cagatgtctc cagccctcac      180

ctgcctagtc ctgggcctgg cccttgtctt tggtgaaggg tctgctgtgc accatccccc      240

atcctacgtg gcccacctgg cctcagactt cggggtgagg gtgtttcagc aggtggcgca      300

ggcctccaag gaccgcaacg tggttttctc accctatggg gtggcctcgg tgttggccat      360

gctccagctg acaacaggag gagaaaccca gcagcagatt caagcagcta tgggattcaa      420

gattgatgac aagggcatgg cccccgccct ccggcatctg tacaaggagc tcatggggcc      480

atggaacaag gatgagatca gcaccacaga cgcgatcttc gtccagcggg atctgaagct      540

ggtccagggc ttcatgcccc acttcttcag gctgttccgg agcacggtca agcaagtgga      600

cttttcagag gtggagagag ccagattcat catcaatgac tgggtgaaga cacacacaaa      660

aggtatgatc agcaacttgc ttgggaaagg agccgtggac cagctgacac ggctggtgct      720

ggtgaatgcc ctctacttca acggccagtg gaagactccc ttccccgact ccagcaccca      780

ccgccgcctc ttccacaaat cagacggcag cactgtctct gtgcccatga tggctcagac      840

caacaagttc aactatactg agttcaccac gcccgatggc cattactacg acatcctgga      900

actgccctac cacggggaca ccctcagcat gttcattgct gccccttatg aaaaagaggt      960

gcctctctct gccctcacca acattctgag tgcccagctc atcagccact ggaaaggcaa     1020

catgaccagg ctgccccgcc tcctggttct gcccaagttc tccctggaga ctgaagtcga     1080

cctcaggaag cccctagaga acctgggaat gaccgacatg ttcagacagt ttcaggctga     1140

cttcacgagt ctttcagacc aagagcctct ccacgtcgcg caggcgctgc agaaagtgaa     1200

gatcgaggtg aacgagagtg gcacggtggc ctcctcatcc acagctgtca tagtctcagc     1260

ccgcatggcc cccgaggaga tcatcatgga cagacccttc ctctttgtgg tccggcacaa     1320

ccccacagga acagtccttt tcatgggcca agtgatggaa ccctgaccct ggggaaagac     1380

gccttcatct gggacaaaac tggagatgca tcgggaaaga agaaactccg aagaaaagaa     1440

ttttagtgtt aatgactctt tctgaaggaa gagaagacat ttgccttttg ttaaaagatg     1500

gtaaaccaga tctgtctcca agaccttggc ctctccttgg aggaccttta ggtcaaactc     1560

cctagtctcc acctgagacc ctgggagaga agtttgaagc acaactccct taaggtctcc     1620

aaaccagacg gtgacgcctg cgggaccatc tggggcacct gcttccaccc gtctctctgc     1680

ccactcgggt ctgcagacct ggttcccact gaggcccttt gcaggatgga actacggggc     1740

ttacaggagc ttttgtgtgc ctggtagaaa ctatttctgt tccagtcaca ttgccatcac     1800

tcttgtactg cctgccaccg cggaggaggc tggtgacagg ccaaaggcca gtggaagaaa     1860

caccctttca tctcagagtc cactgtggca ctggccaccc ctccccagta caggggtgct     1920

gcaggtggca gagtgaatgt cccccatcat gtggcccaac tctcctggcc tggccatctc     1980

cctccccaga aacagtgtgc atgggttatt ttggagtgta ggtgacttgt ttactcattg     2040

aagcagattt ctgcttcctt ttatttttat aggaatagag gaagaaatgt cagatgcgtg     2100

cccagctctt caccccccaa tctcttggtg gggaggggtg tacctaaata tttatcatat     2160

ccttgccctt gagtgcttgt tagagagaaa gagaactact aaggaaaata atattattta     2220

aactcgctcc tagtgtttct ttgtggtctg tgtcaccgta tctcaggaag tccagccact     2280

tgactggcac acacccctcc ggacatccag cgtgacggag cccacactgc caccttgtgg     2340

ccgcctgaga ccctcgcgcc ccccgcgccc ctctttttcc ccttgatgga aattgaccat     2400

acaatttcat cctccttcag gggatcaaaa ggacggagtg gggggacaga gactcagatg     2460

aggacagagt ggtttccaat gtgttcaata gatttaggag cagaaatgca aggggctgca     2520

tgacctacca ggacagaact ttccccaatt acagggtgac tcacagccgc attggtgact     2580

cacttcaatg tgtcatttcc ggctgctgtg tgtgagcagt ggacacgtga ggggggggtg     2640

ggtgagagag acaggcagct cggattcaac taccttagat aatatttctg aaaacctacc     2700

agccagaggg tagggcacaa agatggatgt aatgcacttt gggaggccaa ggcgggagga     2760

ttgcttgagc ccaggagttc aagaccagcc tgggcaacat accaagaccc ccgtctcttt     2820

aaaaatatat atattttaaa tatacttaaa tatatatttc taatatcttt aaatatatat     2880

atatatttta aagaccaatt tatgggagaa ttgcacacag atgtgaaatg aatgtaatct     2940

aatagaagcc taatcagccc accatgttct ccactgaaaa atcctctttc tttggggttt     3000

ttctttcttt cttttttgat tttgcactgg acggtgacgt cagccatgta caggatccac     3060

aggggtggtg tcaaatgcta ttgaaattgt gttgaattgt atgctttttc acttttgata     3120

aataaacatg taaaaatgtt tcaaaaaaat aataaaataa ataaatacga agaatatgtc     3180

aggacagtca aaaaaaaaaa aaaaaaa                                         3207


<210> 80
<211> 402
<212> PRT
<213> Homo sapiens

<400> 80
Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210> 81
<211> 3162
<212> DNA
<213> Homo sapiens

<400> 81
ggcccacaga ggagcacagc tgtgtttggc tgcagggcca agagcgctgt caagaagacc       60

cacacgcccc cctccagcag ctgaattcct gcagctcagc agccgccgcc agagcaggac      120

gaaccgccaa tcgcaaggca cctctgagaa cttcaggatg cagatgtctc cagccctcac      180

ctgcctagtc ctgggcctgg cccttgtctt tggtgaaggg tctgctgtgc accatccccc      240

atcctacgtg gcgcaggcct ccaaggaccg caacgtggtt ttctcaccct atggggtggc      300

ctcggtgttg gccatgctcc agctgacaac aggaggagaa acccagcagc agattcaagc      360

agctatggga ttcaagattg atgacaaggg catggccccc gccctccggc atctgtacaa      420

ggagctcatg gggccatgga acaaggatga gatcagcacc acagacgcga tcttcgtcca      480

gcgggatctg aagctggtcc agggcttcat gccccacttc ttcaggctgt tccggagcac      540

ggtcaagcaa gtggactttt cagaggtgga gagagccaga ttcatcatca atgactgggt      600

gaagacacac acaaaaggta tgatcagcaa cttgcttggg aaaggagccg tggaccagct      660

gacacggctg gtgctggtga atgccctcta cttcaacggc cagtggaaga ctcccttccc      720

cgactccagc acccaccgcc gcctcttcca caaatcagac ggcagcactg tctctgtgcc      780

catgatggct cagaccaaca agttcaacta tactgagttc accacgcccg atggccatta      840

ctacgacatc ctggaactgc cctaccacgg ggacaccctc agcatgttca ttgctgcccc      900

ttatgaaaaa gaggtgcctc tctctgccct caccaacatt ctgagtgccc agctcatcag      960

ccactggaaa ggcaacatga ccaggctgcc ccgcctcctg gttctgccca agttctccct     1020

ggagactgaa gtcgacctca ggaagcccct agagaacctg ggaatgaccg acatgttcag     1080

acagtttcag gctgacttca cgagtctttc agaccaagag cctctccacg tcgcgcaggc     1140

gctgcagaaa gtgaagatcg aggtgaacga gagtggcacg gtggcctcct catccacagc     1200

tgtcatagtc tcagcccgca tggcccccga ggagatcatc atggacagac ccttcctctt     1260

tgtggtccgg cacaacccca caggaacagt ccttttcatg ggccaagtga tggaaccctg     1320

accctgggga aagacgcctt catctgggac aaaactggag atgcatcggg aaagaagaaa     1380

ctccgaagaa aagaatttta gtgttaatga ctctttctga aggaagagaa gacatttgcc     1440

ttttgttaaa agatggtaaa ccagatctgt ctccaagacc ttggcctctc cttggaggac     1500

ctttaggtca aactccctag tctccacctg agaccctggg agagaagttt gaagcacaac     1560

tcccttaagg tctccaaacc agacggtgac gcctgcggga ccatctgggg cacctgcttc     1620

cacccgtctc tctgcccact cgggtctgca gacctggttc ccactgaggc cctttgcagg     1680

atggaactac ggggcttaca ggagcttttg tgtgcctggt agaaactatt tctgttccag     1740

tcacattgcc atcactcttg tactgcctgc caccgcggag gaggctggtg acaggccaaa     1800

ggccagtgga agaaacaccc tttcatctca gagtccactg tggcactggc cacccctccc     1860

cagtacaggg gtgctgcagg tggcagagtg aatgtccccc atcatgtggc ccaactctcc     1920

tggcctggcc atctccctcc ccagaaacag tgtgcatggg ttattttgga gtgtaggtga     1980

cttgtttact cattgaagca gatttctgct tccttttatt tttataggaa tagaggaaga     2040

aatgtcagat gcgtgcccag ctcttcaccc cccaatctct tggtggggag gggtgtacct     2100

aaatatttat catatccttg cccttgagtg cttgttagag agaaagagaa ctactaagga     2160

aaataatatt atttaaactc gctcctagtg tttctttgtg gtctgtgtca ccgtatctca     2220

ggaagtccag ccacttgact ggcacacacc cctccggaca tccagcgtga cggagcccac     2280

actgccacct tgtggccgcc tgagaccctc gcgccccccg cgcccctctt tttccccttg     2340

atggaaattg accatacaat ttcatcctcc ttcaggggat caaaaggacg gagtgggggg     2400

acagagactc agatgaggac agagtggttt ccaatgtgtt caatagattt aggagcagaa     2460

atgcaagggg ctgcatgacc taccaggaca gaactttccc caattacagg gtgactcaca     2520

gccgcattgg tgactcactt caatgtgtca tttccggctg ctgtgtgtga gcagtggaca     2580

cgtgaggggg gggtgggtga gagagacagg cagctcggat tcaactacct tagataatat     2640

ttctgaaaac ctaccagcca gagggtaggg cacaaagatg gatgtaatgc actttgggag     2700

gccaaggcgg gaggattgct tgagcccagg agttcaagac cagcctgggc aacataccaa     2760

gacccccgtc tctttaaaaa tatatatatt ttaaatatac ttaaatatat atttctaata     2820

tctttaaata tatatatata ttttaaagac caatttatgg gagaattgca cacagatgtg     2880

aaatgaatgt aatctaatag aagcctaatc agcccaccat gttctccact gaaaaatcct     2940

ctttctttgg ggtttttctt tctttctttt ttgattttgc actggacggt gacgtcagcc     3000

atgtacagga tccacagggg tggtgtcaaa tgctattgaa attgtgttga attgtatgct     3060

ttttcacttt tgataaataa acatgtaaaa atgtttcaaa aaaataataa aataaataaa     3120

tacgaagaat atgtcaggac agtcaaaaaa aaaaaaaaaa aa                        3162


<210> 82
<211> 387
<212> PRT
<213> Homo sapiens

<400> 82
Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


Gln Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala 
        35                  40                  45              


Ser Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln 
    50                  55                  60                  


Gln Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala 
65                  70                  75                  80  


Pro Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys 
                85                  90                  95      


Asp Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys 
            100                 105                 110         


Leu Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr 
        115                 120                 125             


Val Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile 
    130                 135                 140                 


Asn Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu 
145                 150                 155                 160 


Gly Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala 
                165                 170                 175     


Leu Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr 
            180                 185                 190         


His Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro 
        195                 200                 205             


Met Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro 
    210                 215                 220                 


Asp Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr 
225                 230                 235                 240 


Leu Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser 
                245                 250                 255     


Ala Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly 
            260                 265                 270         


Asn Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu 
        275                 280                 285             


Glu Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr 
    290                 295                 300                 


Asp Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln 
305                 310                 315                 320 


Glu Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val 
                325                 330                 335     


Asn Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser 
            340                 345                 350         


Ala Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe 
        355                 360                 365             


Val Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val 
    370                 375                 380                 


Met Glu Pro 
385         


<210> 83
<211> 9093
<212> DNA
<213> Homo sapiens

<400> 83
cgagcccagt cgagccgcgc tcacctcggg ctcccgctcc gtctccacct ccgcctttgc       60

cctggcggcg cgaccccgtc ccgggcgcgg cccccagcag tcgcgcgccg ttagcctcgc      120

gcccgccgcg cagtccgggc ccggcgcgat gggggccgcc gccggccgga gcccccacct      180

ggggcccgcg cccgcccgcc gcccgcagcg ctctctgctc ctgctgcagc tgctgctgct      240

cgtcgctgcc ccggggtcca cgcaggccca ggccgccccg ttccccgagc tgtgcagtta      300

tacatgggaa gctgttgata ccaaaaataa tgtactttat aaaatcaaca tctgtggaag      360

tgtggatatt gtccagtgcg ggccatcaag tgctgtttgt atgcacgact tgaagacacg      420

cacttatcat tcagtgggtg actctgtttt gagaagtgca accagatctc tcctggaatt      480

caacacaaca gtgagctgtg accagcaagg cacaaatcac agagtccaga gcagcattgc      540

cttcctgtgt gggaaaaccc tgggaactcc tgaatttgta actgcaacag aatgtgtgca      600

ctactttgag tggaggacca ctgcagcctg caagaaagac atatttaaag caaataagga      660

ggtgccatgc tatgtgtttg atgaagagtt gaggaagcat gatctcaatc ctctgatcaa      720

gcttagtggt gcctacttgg tggatgactc cgatccggac acttctctat tcatcaatgt      780

ttgtagagac atagacacac tacgagaccc aggttcacag ctgcgggcct gtccccccgg      840

cactgccgcc tgcctggtaa gaggacacca ggcgtttgat gttggccagc cccgggacgg      900

actgaagctg gtgcgcaagg acaggcttgt cctgagttac gtgagggaag aggcaggaaa      960

gctagacttt tgtgatggtc acagccctgc ggtgactatt acatttgttt gcccgtcgga     1020

gcggagagag ggcaccattc ccaaactcac agctaaatcc aactgccgct atgaaattga     1080

gtggattact gagtatgcct gccacagaga ttacctggaa agtaaaactt gttctctgag     1140

cggcgagcag caggatgtct ccatagacct cacaccactt gcccagagcg gaggttcatc     1200

ctatatttca gatggaaaag aatatttgtt ttatttgaat gtctgtggag aaactgaaat     1260

acagttctgt aataaaaaac aagctgcagt ttgccaagtg aaaaagagcg atacctctca     1320

agtcaaagca gcaggaagat accacaatca gaccctccga tattcggatg gagacctcac     1380

cttgatatat tttggaggtg atgaatgcag ctcagggttt cagcggatga gcgtcataaa     1440

ctttgagtgc aataaaaccg caggtaacga tgggaaagga actcctgtat tcacagggga     1500

ggttgactgc acctacttct tcacatggga cacggaatac gcctgtgtta aggagaagga     1560

agacctcctc tgcggtgcca ccgacgggaa gaagcgctat gacctgtccg cgctggtccg     1620

ccatgcagaa ccagagcaga attgggaagc tgtggatggc agtcagacgg aaacagagaa     1680

gaagcatttt ttcattaata tttgtcacag agtgctgcag gaaggcaagg cacgagggtg     1740

tcccgaggac gcggcagtgt gtgcagtgga taaaaatgga agtaaaaatc tgggaaaatt     1800

tatttcctct cccatgaaag agaaaggaaa cattcaactc tcttattcag atggtgatga     1860

ttgtggtcat ggcaagaaaa ttaaaactaa tatcacactt gtatgcaagc caggtgatct     1920

ggaaagtgca ccagtgttga gaacttctgg ggaaggcggt tgcttttatg agtttgagtg     1980

gcacacagct gcggcctgtg tgctgtctaa gacagaaggg gagaactgca cggtctttga     2040

ctcccaggca gggttttctt ttgacttatc acctctcaca aagaaaaatg gtgcctataa     2100

agttgagaca aagaagtatg acttttatat aaatgtgtgt ggcccggtgt ctgtgagccc     2160

ctgtcagcca gactcaggag cctgccaggt ggcaaaaagt gatgagaaga cttggaactt     2220

gggtctgagt aatgcgaagc tttcatatta tgatgggatg atccaactga actacagagg     2280

cggcacaccc tataacaatg aaagacacac accgagagct acgctcatca cctttctctg     2340

tgatcgagac gcgggagtgg gcttccctga atatcaggaa gaggataact ccacctacaa     2400

cttccggtgg tacaccagct atgcctgccc ggaggagccc ctggaatgcg tagtgaccga     2460

cccctccacg ctggagcagt acgacctctc cagtctggca aaatctgaag gtggccttgg     2520

aggaaactgg tatgccatgg acaactcagg ggaacatgtc acgtggagga aatactacat     2580

taacgtgtgt cggcctctga atccagtgcc gggctgcaac cgatatgcat cggcttgcca     2640

gatgaagtat gaaaaagatc agggctcctt cactgaagtg gtttccatca gtaacttggg     2700

aatggcaaag accggcccgg tggttgagga cagcggcagc ctccttctgg aatacgtgaa     2760

tgggtcggcc tgcaccacca gcgatggcag acagaccaca tataccacga ggatccatct     2820

cgtctgctcc aggggcaggc tgaacagcca ccccatcttt tctctcaact gggagtgtgt     2880

ggtcagtttc ctgtggaaca cagaggctgc ctgtcccatt cagacaacga cggatacaga     2940

ccaggcttgc tctataaggg atcccaacag tggatttgtg tttaatctta atccgctaaa     3000

cagttcgcaa ggatataacg tctctggcat tgggaagatt tttatgttta atgtctgcgg     3060

cacaatgcct gtctgtggga ccatcctggg aaaacctgct tctggctgtg aggcagaaac     3120

ccaaactgaa gagctcaaga attggaagcc agcaaggcca gtcggaattg agaaaagcct     3180

ccagctgtcc acagagggct tcatcactct gacctacaaa gggcctctct ctgccaaagg     3240

taccgctgat gcttttatcg tccgctttgt ttgcaatgat gatgtttact cagggcccct     3300

caaattcctg catcaagata tcgactctgg gcaagggatc cgaaacactt actttgagtt     3360

tgaaaccgcg ttggcctgtg ttccttctcc agtggactgc caagtcaccg acctggctgg     3420

aaatgagtac gacctgactg gcctaagcac agtcaggaaa ccttggacgg ctgttgacac     3480

ctctgtcgat gggagaaaga ggactttcta tttgagcgtt tgcaatcctc tcccttacat     3540

tcctggatgc cagggcagcg cagtggggtc ttgcttagtg tcagaaggca atagctggaa     3600

tctgggtgtg gtgcagatga gtccccaagc cgcggcgaat ggatctttga gcatcatgta     3660

tgtcaacggt gacaagtgtg ggaaccagcg cttctccacc aggatcacgt ttgagtgtgc     3720

tcagatatcg ggctcaccag catttcagct tcaggatggt tgtgagtacg tgtttatctg     3780

gagaactgtg gaagcctgtc ccgttgtcag agtggaaggg gacaactgtg aggtgaaaga     3840

cccaaggcat ggcaacttgt atgacctgaa gcccctgggc ctcaacgaca ccatcgtgag     3900

cgctggcgaa tacacttatt acttccgggt ctgtgggaag ctttcctcag acgtctgccc     3960

cacaagtgac aagtccaagg tggtctcctc atgtcaggaa aagcgggaac cgcagggatt     4020

tcacaaagtg gcaggtctcc tgactcagaa gctaacttat gaaaatggct tgttaaaaat     4080

gaacttcacg gggggggaca cttgccataa ggtttatcag cgctccacag ccatcttctt     4140

ctactgtgac cgcggcaccc agcggccagt atttctaaag gagacttcag attgttccta     4200

cttgtttgag tggcgaacgc agtatgcctg cccacctttc gatctgactg aatgttcatt     4260

caaagatggg gctggcaact ccttcgacct ctcgtccctg tcaaggtaca gtgacaactg     4320

ggaagccatc actgggacgg gggacccgga gcactacctc atcaatgtct gcaagtctct     4380

ggccccgcag gctggcactg agccgtgccc tccagaagca gccgcgtgtc tgctgggtgg     4440

ctccaagccc gtgaacctcg gcagggtaag ggacggacct cagtggagag atggcataat     4500

tgtcctgaaa tacgttgatg gcgacttatg tccagatggg attcggaaaa agtcaaccac     4560

catccgattc acctgcagcg agagccaagt gaactccagg cccatgttca tcagcgccgt     4620

ggaggactgt gagtacacct ttgcctggcc cacagccaca gcctgtccca tgaagagcaa     4680

cgagcatgat gactgccagg tcaccaaccc aagcacagga cacctgtttg atctgagctc     4740

cttaagtggc agggcgggat tcacagctgc ttacagcgag aaggggttgg tttacatgag     4800

catctgtggg gagaatgaaa actgccctcc tggcgtgggg gcctgctttg gacagaccag     4860

gattagcgtg ggcaaggcca acaagaggct gagatacgtg gaccaggtcc tgcagctggt     4920

gtacaaggat gggtcccctt gtccctccaa atccggcctg agctataaga gtgtgatcag     4980

tttcgtgtgc aggcctgagg ccgggccaac caataggccc atgctcatct ccctggacaa     5040

gcagacatgc actctcttct tctcctggca cacgccgctg gcctgcgagc aagcgaccga     5100

atgttccgtg aggaatggaa gctctattgt tgacttgtct ccccttattc atcgcactgg     5160

tggttatgag gcttatgatg agagtgagga tgatgcctcc gataccaacc ctgatttcta     5220

catcaatatt tgtcagccac taaatcccat gcacggagtg ccctgtcctg ccggagccgc     5280

tgtgtgcaaa gttcctattg atggtccccc catagatatc ggccgggtag caggaccacc     5340

aatactcaat ccaatagcaa atgagattta cttgaatttt gaaagcagta ctccttgctt     5400

agcggacaag catttcaact acacctcgct catcgcgttt cactgtaaga gaggtgtgag     5460

catgggaacg cctaagctgt taaggaccag cgagtgcgac tttgtgttcg aatgggagac     5520

tcctgtcgtc tgtcctgatg aagtgaggat ggatggctgt accctgacag atgagcagct     5580

cctctacagc ttcaacttgt ccagcctttc cacgagcacc tttaaggtga ctcgcgactc     5640

gcgcacctac agcgttgggg tgtgcacctt tgcagtcggg ccagaacaag gaggctgtaa     5700

ggacggagga gtctgtctgc tctcaggcac caagggggca tcctttggac ggctgcaatc     5760

aatgaaactg gattacaggc accaggatga agcggtcgtt ttaagttacg tgaatggtga     5820

tcgttgccct ccagaaaccg atgacggcgt cccctgtgtc ttccccttca tattcaatgg     5880

gaagagctac gaggagtgca tcatagagag cagggcgaag ctgtggtgta gcacaactgc     5940

ggactacgac agagaccacg agtggggctt ctgcagacac tcaaacagct accggacatc     6000

cagcatcata tttaagtgtg atgaagatga ggacattggg aggccacaag tcttcagtga     6060

agtgcgtggg tgtgatgtga catttgagtg gaaaacaaaa gttgtctgcc ctccaaagaa     6120

gttggagtgc aaattcgtcc agaaacacaa aacctacgac ctgcggctgc tctcctctct     6180

caccgggtcc tggtccctgg tccacaacgg agtctcgtac tatataaatc tgtgccagaa     6240

aatatataaa gggcccctgg gctgctctga aagggccagc atttgcagaa ggaccacaac     6300

tggtgacgtc caggtcctgg gactcgttca cacgcagaag ctgggtgtca taggtgacaa     6360

agttgttgtc acgtactcca aaggttatcc gtgtggtgga aataagaccg catcctccgt     6420

gatagaattg acctgtacaa agacggtggg cagacctgca ttcaagaggt ttgatatcga     6480

cagctgcact tactacttca gctgggactc ccgggctgcc tgcgccgtga agcctcagga     6540

ggtgcagatg gtgaatggga ccatcaccaa ccctataaat ggcaagagct tcagcctcgg     6600

agatatttat tttaagctgt tcagagcctc tggggacatg aggaccaatg gggacaacta     6660

cctgtatgag atccaacttt cctccatcac aagctccaga aacccggcgt gctctggagc     6720

caacatatgc caggtgaagc ccaacgatca gcacttcagt cggaaagttg gaacctctga     6780

caagaccaag tactaccttc aagacggcga tctcgatgtc gtgtttgcct cttcctctaa     6840

gtgcggaaag gataagacca agtctgtttc ttccaccatc ttcttccact gtgaccctct     6900

ggtggaggac gggatccccg agttcagtca cgagactgcc gactgccagt acctcttctc     6960

ttggtacacc tcagccgtgt gtcctctggg ggtgggcttt gacagcgaga atcccgggga     7020

cgacgggcag atgcacaagg ggctgtcaga acggagccag gcagtcggcg cggtgctcag     7080

cctgctgctg gtggcgctca cctgctgcct gctggccctg ttgctctaca agaaggagag     7140

gagggaaaca gtgataagta agctgaccac ttgctgtagg agaagttcca acgtgtccta     7200

caaatactca aaggtgaata aggaagaaga gacagatgag aatgaaacag agtggctgat     7260

ggaagagatc cagctgcctc ctccacggca gggaaaggaa gggcaggaga acggccatat     7320

taccaccaag tcagtgaaag ccctcagctc cctgcatggg gatgaccagg acagtgagga     7380

tgaggttctg accatcccag aggtgaaagt tcactcgggc aggggagctg gggcagagag     7440

ctcccaccca gtgagaaacg cacagagcaa tgcccttcag gagcgtgagg acgatagggt     7500

ggggctggtc aggggtgaga aggcgaggaa agggaagtcc agctctgcac agcagaagac     7560

agtgagctcc accaagctgg tgtccttcca tgacgacagc gacgaggacc tcttacacat     7620

ctgactccgc agtgcctgca ggggagcacg gagccgcggg acagccaagc acctccaacc     7680

aaataagact tccactcgat gatgcttcta taattttgcc tttaacagaa actttcaaaa     7740

gggaagagtt tttgtgatgg gggagagggt gaaggaggtc aggccccact ccttcctgat     7800

tgtttacagt cattggaata aggcatggct cagatcggcc acagggcggt accttgtgcc     7860

cagggttttg ccccaagtcc tcatttaaaa gcataaggcc ggacgcatct caaaacagag     7920

ggctgcattc gaagaaaccc ttgctgcttt agtcccgata gggtatttga ccccgatata     7980

ttttagcatt ttaattctct ccccctattt attgactttg acaattactc aggtttgaga     8040

aaaaggaaaa aaaaacagcc accgtttctt cctgccagca ggggtgtgat gtaccagttt     8100

gtccatcttg agatggtgag gctgtcagtg tatggggcag cttccggcgg gatgttgaac     8160

tggtcattaa tgtgtcccct gagttggagc tcattctgtc tcttttctct tttgctttct     8220

gtttcttaag ggcacacaca cgtgcgtgcg agcacacaca cacatacgtg cacagggtcc     8280

ccgagtgcct aggttttgga gagtttgcct gttctatgcc tttagtcagg aatggctgca     8340

cctttttgca tgatatcttc aagcctgggc gtacagagca catttgtcag tatttttgcc     8400

ggctggtgaa ttcaaacaac ctgcccaaag attgatttgt gtgtttgtgt gtgtgtgtgt     8460

gtgtgtgtgt gtgtgtgtga gtggagttga ggtgtcagag aaaatgaatt ttttccagat     8520

ttggggtata ggtctcatct cttcaggttc tcatgatacc acctttactg tgcttatttt     8580

tttaagaaaa aagtgttgat caaccattcg acctataaga agccttaatt tgcacagtgt     8640

gtgacttaca gaaactgcat gaaaaatcat gggccagagc ctcggcccta gcattgcact     8700

tggcctcatg ctggagggag gctgggcggg tacagcgcgg aggaggaggg aggccaggcg     8760

ggcatggcgt ggaggaggag ggaggccggg cggtcacagc atggaggagg agggaggcgc     8820

tgctggtgtt cttattctgg cggcagcgcc tttcctgcca tgtttagtga atgacttttc     8880

tcgcattgta gaattgtata tagactctgg tgttctattg ctgagaagca aaccgccctg     8940

cagcatccct cagcctgtac cggtttggct ggcttgtttg atttcaacat gagtgtattt     9000

tttaaaattg atttttctct tcattttttt ttcaatcaac tttactgtaa tataaagtat     9060

tcaacaattt caataaaaga taaattatta aaa                                  9093


<210> 84
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 84
Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala 
1               5                   10                  15      


Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val 
            20                  25                  30          


Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu 
        35                  40                  45              


Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr 
    50                  55                  60                  


Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser 
65                  70                  75                  80  


Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val 
                85                  90                  95      


Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn 
            100                 105                 110         


Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser 
        115                 120                 125             


Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val 
    130                 135                 140                 


Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val 
                165                 170                 175     


Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu 
            180                 185                 190         


Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe 
        195                 200                 205             


Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln 
    210                 215                 220                 


Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His 
225                 230                 235                 240 


Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg 
                245                 250                 255     


Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu 
            260                 265                 270         


Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys 
        275                 280                 285             


Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser 
    290                 295                 300                 


Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg 
305                 310                 315                 320 


Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp 
                325                 330                 335     


Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr 
            340                 345                 350         


Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu 
        355                 360                 365             


Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val 
    370                 375                 380                 


Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn 
385                 390                 395                 400 


Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly 
                405                 410                 415     


Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe 
            420                 425                 430         


Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe 
        435                 440                 445             


Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr 
    450                 455                 460                 


Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly 
465                 470                 475                 480 


Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu 
                485                 490                 495     


Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys 
            500                 505                 510         


His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala 
        515                 520                 525             


Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly 
    530                 535                 540                 


Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly 
545                 550                 555                 560 


Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys 
                565                 570                 575     


Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu 
            580                 585                 590         


Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu 
        595                 600                 605             


Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly 
    610                 615                 620                 


Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu 
625                 630                 635                 640 


Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys 
                645                 650                 655     


Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys 
            660                 665                 670         


Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr 
        675                 680                 685             


Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met 
    690                 695                 700                 


Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His 
705                 710                 715                 720 


Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly 
                725                 730                 735     


Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe 
            740                 745                 750         


Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val 
        755                 760                 765             


Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala 
    770                 775                 780                 


Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser 
785                 790                 795                 800 


Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro 
                805                 810                 815     


Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met 
            820                 825                 830         


Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser 
        835                 840                 845             


Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser 
    850                 855                 860                 


Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly 
865                 870                 875                 880 


Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly 
                885                 890                 895     


Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val 
            900                 905                 910         


Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr 
        915                 920                 925             


Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val 
    930                 935                 940                 


Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly 
945                 950                 955                 960 


Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys 
                965                 970                 975     


Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln 
            980                 985                 990         


Thr Glu Glu Leu Lys Asn Trp Lys  Pro Ala Arg Pro Val  Gly Ile Glu 
        995                 1000                 1005             


Lys Ser  Leu Gln Leu Ser Thr  Glu Gly Phe Ile Thr  Leu Thr Tyr 
    1010                 1015                 1020             


Lys Gly  Pro Leu Ser Ala Lys  Gly Thr Ala Asp Ala  Phe Ile Val 
    1025                 1030                 1035             


Arg Phe  Val Cys Asn Asp Asp  Val Tyr Ser Gly Pro  Leu Lys Phe 
    1040                 1045                 1050             


Leu His  Gln Asp Ile Asp Ser  Gly Gln Gly Ile Arg  Asn Thr Tyr 
    1055                 1060                 1065             


Phe Glu  Phe Glu Thr Ala Leu  Ala Cys Val Pro Ser  Pro Val Asp 
    1070                 1075                 1080             


Cys Gln  Val Thr Asp Leu Ala  Gly Asn Glu Tyr Asp  Leu Thr Gly 
    1085                 1090                 1095             


Leu Ser  Thr Val Arg Lys Pro  Trp Thr Ala Val Asp  Thr Ser Val 
    1100                 1105                 1110             


Asp Gly  Arg Lys Arg Thr Phe  Tyr Leu Ser Val Cys  Asn Pro Leu 
    1115                 1120                 1125             


Pro Tyr  Ile Pro Gly Cys Gln  Gly Ser Ala Val Gly  Ser Cys Leu 
    1130                 1135                 1140             


Val Ser  Glu Gly Asn Ser Trp  Asn Leu Gly Val Val  Gln Met Ser 
    1145                 1150                 1155             


Pro Gln  Ala Ala Ala Asn Gly  Ser Leu Ser Ile Met  Tyr Val Asn 
    1160                 1165                 1170             


Gly Asp  Lys Cys Gly Asn Gln  Arg Phe Ser Thr Arg  Ile Thr Phe 
    1175                 1180                 1185             


Glu Cys  Ala Gln Ile Ser Gly  Ser Pro Ala Phe Gln  Leu Gln Asp 
    1190                 1195                 1200             


Gly Cys  Glu Tyr Val Phe Ile  Trp Arg Thr Val Glu  Ala Cys Pro 
    1205                 1210                 1215             


Val Val  Arg Val Glu Gly Asp  Asn Cys Glu Val Lys  Asp Pro Arg 
    1220                 1225                 1230             


His Gly  Asn Leu Tyr Asp Leu  Lys Pro Leu Gly Leu  Asn Asp Thr 
    1235                 1240                 1245             


Ile Val  Ser Ala Gly Glu Tyr  Thr Tyr Tyr Phe Arg  Val Cys Gly 
    1250                 1255                 1260             


Lys Leu  Ser Ser Asp Val Cys  Pro Thr Ser Asp Lys  Ser Lys Val 
    1265                 1270                 1275             


Val Ser  Ser Cys Gln Glu Lys  Arg Glu Pro Gln Gly  Phe His Lys 
    1280                 1285                 1290             


Val Ala  Gly Leu Leu Thr Gln  Lys Leu Thr Tyr Glu  Asn Gly Leu 
    1295                 1300                 1305             


Leu Lys  Met Asn Phe Thr Gly  Gly Asp Thr Cys His  Lys Val Tyr 
    1310                 1315                 1320             


Gln Arg  Ser Thr Ala Ile Phe  Phe Tyr Cys Asp Arg  Gly Thr Gln 
    1325                 1330                 1335             


Arg Pro  Val Phe Leu Lys Glu  Thr Ser Asp Cys Ser  Tyr Leu Phe 
    1340                 1345                 1350             


Glu Trp  Arg Thr Gln Tyr Ala  Cys Pro Pro Phe Asp  Leu Thr Glu 
    1355                 1360                 1365             


Cys Ser  Phe Lys Asp Gly Ala  Gly Asn Ser Phe Asp  Leu Ser Ser 
    1370                 1375                 1380             


Leu Ser  Arg Tyr Ser Asp Asn  Trp Glu Ala Ile Thr  Gly Thr Gly 
    1385                 1390                 1395             


Asp Pro  Glu His Tyr Leu Ile  Asn Val Cys Lys Ser  Leu Ala Pro 
    1400                 1405                 1410             


Gln Ala  Gly Thr Glu Pro Cys  Pro Pro Glu Ala Ala  Ala Cys Leu 
    1415                 1420                 1425             


Leu Gly  Gly Ser Lys Pro Val  Asn Leu Gly Arg Val  Arg Asp Gly 
    1430                 1435                 1440             


Pro Gln  Trp Arg Asp Gly Ile  Ile Val Leu Lys Tyr  Val Asp Gly 
    1445                 1450                 1455             


Asp Leu  Cys Pro Asp Gly Ile  Arg Lys Lys Ser Thr  Thr Ile Arg 
    1460                 1465                 1470             


Phe Thr  Cys Ser Glu Ser Gln  Val Asn Ser Arg Pro  Met Phe Ile 
    1475                 1480                 1485             


Ser Ala  Val Glu Asp Cys Glu  Tyr Thr Phe Ala Trp  Pro Thr Ala 
    1490                 1495                 1500             


Thr Ala  Cys Pro Met Lys Ser  Asn Glu His Asp Asp  Cys Gln Val 
    1505                 1510                 1515             


Thr Asn  Pro Ser Thr Gly His  Leu Phe Asp Leu Ser  Ser Leu Ser 
    1520                 1525                 1530             


Gly Arg  Ala Gly Phe Thr Ala  Ala Tyr Ser Glu Lys  Gly Leu Val 
    1535                 1540                 1545             


Tyr Met  Ser Ile Cys Gly Glu  Asn Glu Asn Cys Pro  Pro Gly Val 
    1550                 1555                 1560             


Gly Ala  Cys Phe Gly Gln Thr  Arg Ile Ser Val Gly  Lys Ala Asn 
    1565                 1570                 1575             


Lys Arg  Leu Arg Tyr Val Asp  Gln Val Leu Gln Leu  Val Tyr Lys 
    1580                 1585                 1590             


Asp Gly  Ser Pro Cys Pro Ser  Lys Ser Gly Leu Ser  Tyr Lys Ser 
    1595                 1600                 1605             


Val Ile  Ser Phe Val Cys Arg  Pro Glu Ala Gly Pro  Thr Asn Arg 
    1610                 1615                 1620             


Pro Met  Leu Ile Ser Leu Asp  Lys Gln Thr Cys Thr  Leu Phe Phe 
    1625                 1630                 1635             


Ser Trp  His Thr Pro Leu Ala  Cys Glu Gln Ala Thr  Glu Cys Ser 
    1640                 1645                 1650             


Val Arg  Asn Gly Ser Ser Ile  Val Asp Leu Ser Pro  Leu Ile His 
    1655                 1660                 1665             


Arg Thr  Gly Gly Tyr Glu Ala  Tyr Asp Glu Ser Glu  Asp Asp Ala 
    1670                 1675                 1680             


Ser Asp  Thr Asn Pro Asp Phe  Tyr Ile Asn Ile Cys  Gln Pro Leu 
    1685                 1690                 1695             


Asn Pro  Met His Gly Val Pro  Cys Pro Ala Gly Ala  Ala Val Cys 
    1700                 1705                 1710             


Lys Val  Pro Ile Asp Gly Pro  Pro Ile Asp Ile Gly  Arg Val Ala 
    1715                 1720                 1725             


Gly Pro  Pro Ile Leu Asn Pro  Ile Ala Asn Glu Ile  Tyr Leu Asn 
    1730                 1735                 1740             


Phe Glu  Ser Ser Thr Pro Cys  Leu Ala Asp Lys His  Phe Asn Tyr 
    1745                 1750                 1755             


Thr Ser  Leu Ile Ala Phe His  Cys Lys Arg Gly Val  Ser Met Gly 
    1760                 1765                 1770             


Thr Pro  Lys Leu Leu Arg Thr  Ser Glu Cys Asp Phe  Val Phe Glu 
    1775                 1780                 1785             


Trp Glu  Thr Pro Val Val Cys  Pro Asp Glu Val Arg  Met Asp Gly 
    1790                 1795                 1800             


Cys Thr  Leu Thr Asp Glu Gln  Leu Leu Tyr Ser Phe  Asn Leu Ser 
    1805                 1810                 1815             


Ser Leu  Ser Thr Ser Thr Phe  Lys Val Thr Arg Asp  Ser Arg Thr 
    1820                 1825                 1830             


Tyr Ser  Val Gly Val Cys Thr  Phe Ala Val Gly Pro  Glu Gln Gly 
    1835                 1840                 1845             


Gly Cys  Lys Asp Gly Gly Val  Cys Leu Leu Ser Gly  Thr Lys Gly 
    1850                 1855                 1860             


Ala Ser  Phe Gly Arg Leu Gln  Ser Met Lys Leu Asp  Tyr Arg His 
    1865                 1870                 1875             


Gln Asp  Glu Ala Val Val Leu  Ser Tyr Val Asn Gly  Asp Arg Cys 
    1880                 1885                 1890             


Pro Pro  Glu Thr Asp Asp Gly  Val Pro Cys Val Phe  Pro Phe Ile 
    1895                 1900                 1905             


Phe Asn  Gly Lys Ser Tyr Glu  Glu Cys Ile Ile Glu  Ser Arg Ala 
    1910                 1915                 1920             


Lys Leu  Trp Cys Ser Thr Thr  Ala Asp Tyr Asp Arg  Asp His Glu 
    1925                 1930                 1935             


Trp Gly  Phe Cys Arg His Ser  Asn Ser Tyr Arg Thr  Ser Ser Ile 
    1940                 1945                 1950             


Ile Phe  Lys Cys Asp Glu Asp  Glu Asp Ile Gly Arg  Pro Gln Val 
    1955                 1960                 1965             


Phe Ser  Glu Val Arg Gly Cys  Asp Val Thr Phe Glu  Trp Lys Thr 
    1970                 1975                 1980             


Lys Val  Val Cys Pro Pro Lys  Lys Leu Glu Cys Lys  Phe Val Gln 
    1985                 1990                 1995             


Lys His  Lys Thr Tyr Asp Leu  Arg Leu Leu Ser Ser  Leu Thr Gly 
    2000                 2005                 2010             


Ser Trp  Ser Leu Val His Asn  Gly Val Ser Tyr Tyr  Ile Asn Leu 
    2015                 2020                 2025             


Cys Gln  Lys Ile Tyr Lys Gly  Pro Leu Gly Cys Ser  Glu Arg Ala 
    2030                 2035                 2040             


Ser Ile  Cys Arg Arg Thr Thr  Thr Gly Asp Val Gln  Val Leu Gly 
    2045                 2050                 2055             


Leu Val  His Thr Gln Lys Leu  Gly Val Ile Gly Asp  Lys Val Val 
    2060                 2065                 2070             


Val Thr  Tyr Ser Lys Gly Tyr  Pro Cys Gly Gly Asn  Lys Thr Ala 
    2075                 2080                 2085             


Ser Ser  Val Ile Glu Leu Thr  Cys Thr Lys Thr Val  Gly Arg Pro 
    2090                 2095                 2100             


Ala Phe  Lys Arg Phe Asp Ile  Asp Ser Cys Thr Tyr  Tyr Phe Ser 
    2105                 2110                 2115             


Trp Asp  Ser Arg Ala Ala Cys  Ala Val Lys Pro Gln  Glu Val Gln 
    2120                 2125                 2130             


Met Val  Asn Gly Thr Ile Thr  Asn Pro Ile Asn Gly  Lys Ser Phe 
    2135                 2140                 2145             


Ser Leu  Gly Asp Ile Tyr Phe  Lys Leu Phe Arg Ala  Ser Gly Asp 
    2150                 2155                 2160             


Met Arg  Thr Asn Gly Asp Asn  Tyr Leu Tyr Glu Ile  Gln Leu Ser 
    2165                 2170                 2175             


Ser Ile  Thr Ser Ser Arg Asn  Pro Ala Cys Ser Gly  Ala Asn Ile 
    2180                 2185                 2190             


Cys Gln  Val Lys Pro Asn Asp  Gln His Phe Ser Arg  Lys Val Gly 
    2195                 2200                 2205             


Thr Ser  Asp Lys Thr Lys Tyr  Tyr Leu Gln Asp Gly  Asp Leu Asp 
    2210                 2215                 2220             


Val Val  Phe Ala Ser Ser Ser  Lys Cys Gly Lys Asp  Lys Thr Lys 
    2225                 2230                 2235             


Ser Val  Ser Ser Thr Ile Phe  Phe His Cys Asp Pro  Leu Val Glu 
    2240                 2245                 2250             


Asp Gly  Ile Pro Glu Phe Ser  His Glu Thr Ala Asp  Cys Gln Tyr 
    2255                 2260                 2265             


Leu Phe  Ser Trp Tyr Thr Ser  Ala Val Cys Pro Leu  Gly Val Gly 
    2270                 2275                 2280             


Phe Asp  Ser Glu Asn Pro Gly  Asp Asp Gly Gln Met  His Lys Gly 
    2285                 2290                 2295             


Leu Ser  Glu Arg Ser Gln Ala  Val Gly Ala Val Leu  Ser Leu Leu 
    2300                 2305                 2310             


Leu Val  Ala Leu Thr Cys Cys  Leu Leu Ala Leu Leu  Leu Tyr Lys 
    2315                 2320                 2325             


Lys Glu  Arg Arg Glu Thr Val  Ile Ser Lys Leu Thr  Thr Cys Cys 
    2330                 2335                 2340             


Arg Arg  Ser Ser Asn Val Ser  Tyr Lys Tyr Ser Lys  Val Asn Lys 
    2345                 2350                 2355             


Glu Glu  Glu Thr Asp Glu Asn  Glu Thr Glu Trp Leu  Met Glu Glu 
    2360                 2365                 2370             


Ile Gln  Leu Pro Pro Pro Arg  Gln Gly Lys Glu Gly  Gln Glu Asn 
    2375                 2380                 2385             


Gly His  Ile Thr Thr Lys Ser  Val Lys Ala Leu Ser  Ser Leu His 
    2390                 2395                 2400             


Gly Asp  Asp Gln Asp Ser Glu  Asp Glu Val Leu Thr  Ile Pro Glu 
    2405                 2410                 2415             


Val Lys  Val His Ser Gly Arg  Gly Ala Gly Ala Glu  Ser Ser His 
    2420                 2425                 2430             


Pro Val  Arg Asn Ala Gln Ser  Asn Ala Leu Gln Glu  Arg Glu Asp 
    2435                 2440                 2445             


Asp Arg  Val Gly Leu Val Arg  Gly Glu Lys Ala Arg  Lys Gly Lys 
    2450                 2455                 2460             


Ser Ser  Ser Ala Gln Gln Lys  Thr Val Ser Ser Thr  Lys Leu Val 
    2465                 2470                 2475             


Ser Phe  His Asp Asp Ser Asp  Glu Asp Leu Leu His  Ile 
    2480                 2485                 2490     


<210> 85
<211> 1636
<212> DNA
<213> Homo sapiens

<400> 85
gagaagccaa tcagtgtcgt cgcggtcgct gttctaaagc ccgcacgcac ccaccgggac       60

tcagattctc cccagacgcc gaggatggcc gtcatggcgc cccgaaccct cctcctgcta      120

ctctcggggg ccctggccct gacccagacc tgggcgggct cccactccat gaggtatttc      180

ttcacatccg tgtcccggcc cggccgcggg gagccccgct tcatcgccgt gggctacgtg      240

gacgacacgc agttcgtgcg gttcgacagc gacgccgcga gccagaggat ggagccgcgg      300

gcgccgtgga tagagcagga ggggccggag tattgggacc aggagacacg gaatgtgaag      360

gcccagtcac agactgaccg agtggacctg gggaccctgc gcggctacta caaccagagc      420

gaggccggtt ctcacaccat ccagataatg tatggctgcg acgtggggtc ggacgggcgc      480

ttcctccgcg ggtaccggca ggacgcctac gacggcaagg attacatcgc cctgaacgag      540

gacctgcgct cttggaccgc ggcggacatg gcggctcaga tcaccaagcg caagtgggag      600

gcggcccatg aggcggagca gttgagagcc tacctggatg gcacgtgcgt ggagtggctc      660

cgcagatacc tggagaacgg gaaggagacg ctgcagcgca cggacccccc caagacacat      720

atgacccacc accccatctc tgaccatgag gccaccctga ggtgctgggc cctgggcttc      780

taccctgcgg agatcacact gacctggcag cgggatgggg aggaccagac ccaggacacg      840

gagctcgtgg agaccaggcc tgcaggggat ggaaccttcc agaagtgggc ggctgtggtg      900

gtgccttctg gagaggagca gagatacacc tgccatgtgc agcatgaggg tctgcccaag      960

cccctcaccc tgagatggga gctgtcttcc cagcccacca tccccatcgt gggcatcatt     1020

gctggcctgg ttctccttgg agctgtgatc actggagctg tggtcgctgc cgtgatgtgg     1080

aggaggaaga gctcagatag aaaaggaggg agttacactc aggctgcaag cagtgacagt     1140

gcccagggct ctgatgtgtc cctcacagct tgtaaagtgt gagacagctg ccttgtgtgg     1200

gactgagagg caagagttgt tcctgccctt ccctttgtga cttgaagaac cctgactttg     1260

tttctgcaaa ggcacctgca tgtgtctgtg ttcgtgtagg cataatgtga ggaggtgggg     1320

agaccacccc acccccatgt ccaccatgac cctcttccca cgctgacctg tgctccctcc     1380

ccaatcatct ttcctgttcc agagaggtgg ggctgaggtg tctccatctc tgtctcaact     1440

tcatggtgca ctgagctgta acttcttcct tccctattaa aattagaacc ttagtataaa     1500

tttactttct caaattcttg ccatgagagg ttgatgagtt aattaaagga gaagattcct     1560

aaaatttgag agacaaaata aatggaagac atgagaacct tccagagtcc aaaaaaaaaa     1620

aaaaaaaaaa aaaaaa                                                     1636


<210> 86
<211> 365
<212> PRT
<213> Homo sapiens

<400> 86
Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Asp Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210> 87
<211> 1611
<212> DNA
<213> Homo sapiens

<400> 87
gagaagccaa tcagtgtcgt cgcggtcgct gttctaaagt ccgcacgcac ccaccgggac       60

tcagattctc cccagacgcc gaggatggcc gtcatggcgc cccgaaccct cctcctgcta      120

ctctcggggg ccctggccct gacccagacc tgggcgggct cccactccat gaggtatttc      180

ttcacatccg tgtcccggcc cggccgcggg gagccccgct tcatcgccgt gggctacgtg      240

gacgacacgc agttcgtgcg gttcgacagc gacgccgcga gccagaagat ggagccgcgg      300

gcgccgtgga tagagcagga ggggccggag tattgggacc aggagacacg gaatatgaag      360

gcccactcac agactgaccg agcgaacctg gggaccctgc gcggctacta caaccagagc      420

gaggacggtt ctcacaccat ccagataatg tatggctgcg acgtggggcc ggacgggcgc      480

ttcctccgcg ggtaccggca ggacgcctac gacggcaagg attacatcgc cctgaacgag      540

gacctgcgct cttggaccgc ggcggacatg gcagctcaga tcaccaagcg caagtgggag      600

gcggtccatg cggcggagca gcggagagtc tacctggagg gccggtgcgt ggacgggctc      660

cgcagatacc tggagaacgg gaaggagacg ctgcagcgca cggacccccc caagacacat      720

atgacccacc accccatctc tgaccatgag gccaccctga ggtgctgggc cctgggcttc      780

taccctgcgg agatcacact gacctggcag cgggatgggg aggaccagac ccaggacacg      840

gagctcgtgg agaccaggcc tgcaggggat ggaaccttcc agaagtgggc ggctgtggtg      900

gtgccttctg gagaggagca gagatacacc tgccatgtgc agcatgaggg tctgcccaag      960

cccctcaccc tgagatggga gctgtcttcc cagcccacca tccccatcgt gggcatcatt     1020

gctggcctgg ttctccttgg agctgtgatc actggagctg tggtcgctgc cgtgatgtgg     1080

aggaggaaga gctcagatag aaaaggaggg agttacactc aggctgcaag cagtgacagt     1140

gcccagggct ctgatgtgtc tctcacagct tgtaaagtgt gagacagctg ccttgtgtgg     1200

gactgagagg caagagttgt tcctgccctt ccctttgtga cttgaagaac cctgactttg     1260

tttctgcaaa ggcacctgca tgtgtctgtg ttcgtgtagg cataatgtga ggaggtgggg     1320

agagcacccc acccccatgt ccaccatgac cctcttccca cgctgacctg tgctccctct     1380

ccaatcatct ttcctgttcc agagaggtgg ggctgaggtg tctccatctc tgtctcaact     1440

tcatggtgca ctgagctgta acttcttcct tccctattaa aattagaacc tgagtataaa     1500

tttactttct caaattcttg ccatgagagg ttgatgagtt aattaaagga gaagattcct     1560

aaaatttgag agacaaaatt aatggaacgc atgagaacct tccagagtcc a              1611


<210> 88
<211> 365
<212> PRT
<213> Homo sapiens

<400> 88
Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210> 89
<211> 2588
<212> DNA
<213> Homo sapiens

<400> 89
agcgttgttt ttccttggca gctgcggaga cccgtgataa ttcgttaact aattcaacaa       60

acgggaccct tctgtgtgcc agaaaccgca agcagttgct aacccagtgg gacaggcgga      120

ttggaagagc gggaaggtcc tggcccagag cagtgtggtg agcgctgtgc tggaagggaa      180

tgcgggcagt gggtacttgg tagagcactg actgcctccg gccagaggac ttcccggagg      240

aggtgaccca tgagctggag tggtcagagg aaggctggca aaagggcatc gtggacagag      300

gaacagccta tgtgagtggg agcagagacc ttggccaatg ccattcctta tggccttgta      360

gtggaagcaa ggtgatgggg aaggaacact gtaggggata gctgtccacg gacgctgtct      420

acaagaccct ggagtgagat aacgtgcctg gtactgtgcc ctgcatgtgt aagatgccca      480

gttgaccttc gcagcaggag cctggatcag ggcacttcct gcctcaggta ttgctggaca      540

gcccagacac ttccctctgt gaccatgaaa ctctgggtgt ctgcattgct gatggcctgg      600

tttggtgtcc tgagctgtgt gcaggccgaa ttcttcacct ctattgggca catgactgac      660

ctgatttatg cagagaaaga gctggtgcag tctctgaaag agtacatcct tgtggaggaa      720

gccaagcttt ccaagattaa gagctgggcc aacaaaatgg aagccttgac tagcaagtca      780

gctgctgatg ctgagggcta cctggctcac cctgtgaatg cctacaaact ggtgaagcgg      840

ctaaacacag actggcctgc gctggaggac cttgtcctgc aggactcagc tgcaggtttt      900

atcgccaacc tctctgtgca gcggcagttc ttccccactg atgaggacga gataggagct      960

gccaaagccc tgatgagact tcaggacaca tacaggctgg acccaggcac aatttccaga     1020

ggggaacttc caggaaccaa gtaccaggca atgctgagtg tggatgactg ctttgggatg     1080

ggccgctcgg cctacaatga aggggactat tatcatacgg tgttgtggat ggagcaggtg     1140

ctaaagcagc ttgatgccgg ggaggaggcc accacaacca agtcacaggt gctggactac     1200

ctcagctatg ctgtcttcca gttgggtgat ctgcaccgtg ccctggagct cacccgccgc     1260

ctgctctccc ttgacccaag ccacgaacga gctggaggga atctgcggta ctttgagcag     1320

ttattggagg aagagagaga aaaaacgtta acaaatcaga cagaagctga gctagcaacc     1380

ccagaaggca tctatgagag gcctgtggac tacctgcctg agagggatgt ttacgagagc     1440

ctctgtcgtg gggagggtgt caaactgaca ccccgtagac agaagaggct tttctgtagg     1500

taccaccatg gcaacagggc cccacagctg ctcattgccc ccttcaaaga ggaggacgag     1560

tgggacagcc cgcacatcgt caggtactac gatgtcatgt ctgatgagga aatcgagagg     1620

atcaaggaga tcgcaaaacc taaacttgca cgagccaccg ttcgtgatcc caagacagga     1680

gtcctcactg tcgccagcta ccgggtttcc aaaagctcct ggctagagga agatgatgac     1740

cctgttgtgg cccgagtaaa tcgtcggatg cagcatatca cagggttaac agtaaagact     1800

gcagaattgt tacaggttgc aaattatgga gtgggaggac agtatgaacc gcacttcgac     1860

ttctctagga atgatgagcg agatactttc aagcatttag ggacggggaa tcgtgtggct     1920

actttcttaa actacatgag tgatgtagaa gctggtggtg ccaccgtctt ccctgatctg     1980

ggggctgcaa tttggcctaa gaagggtaca gctgtgttct ggtacaacct cttgcggagc     2040

ggggaaggtg actaccgaac aagacatgct gcctgccctg tgcttgtggg ctgcaagtgg     2100

gtctccaata agtggttcca tgaacgagga caggagttct tgagaccttg tggatcaaca     2160

gaagttgact gacatccttt tctgtccttc cccttcctgg tccttcagcc catgtcaacg     2220

tgacagacac ctttgtatgt tcctttgtat gttcctatca ggctgatttt tggagaaatg     2280

aatgtttgtc tggagcagag ggagaccata ctagggcgac tcctgtgtga ctgaagtccc     2340

agcccttcca ttcagcctgt gccatccctg gccccaaggc taggatcaaa gtggctgcag     2400

cagagttagc tgtctagcgc ctagcaaggt gcctttgtac ctcaggtgtt ttaggtgtga     2460

gatgtttcag tgaaccaaag ttctgatacc ttgtttacat gtttgttttt atggcatttc     2520

tatctattgt ggctttacca aaaaataaaa tgtccctacc agaagcctta aaaaaaaaaa     2580

aaaaaaaa                                                              2588


<210> 90
<211> 535
<212> PRT
<213> Homo sapiens

<400> 90
Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Asn Asp Glu Arg Asp Thr Phe Lys His Leu Gly Thr Gly 
        435                 440                 445             


Asn Arg Val Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly 
    450                 455                 460                 


Gly Ala Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys 
465                 470                 475                 480 


Gly Thr Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp 
                485                 490                 495     


Tyr Arg Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp 
            500                 505                 510         


Val Ser Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro 
        515                 520                 525             


Cys Gly Ser Thr Glu Val Asp 
    530                 535 


<210> 91
<211> 2582
<212> DNA
<213> Homo sapiens

<400> 91
agcgttgttt ttccttggca gctgcggaga cccgtgataa ttcgttaact aattcaacaa       60

acgggaccct tctgtgtgcc agaaaccgca agcagttgct aacccagtgg gacaggcgga      120

ttggaagagc gggaaggtcc tggcccagag cagtgtggtg agcgctgtgc tggaagggaa      180

tgcgggcagt gggtacttgg tagagcactg actgcctccg gccagaggac ttcccggagg      240

aggtgaccca tgagctggag tggtcagagg aaggctggca aaagggcatc gtggacagag      300

gaacagccta tgtgagtggg agcagagacc ttggccaatg ccattcctta tggccttgta      360

gtggaagcaa ggtgatgggg aaggaacact gtaggggata gctgtccacg gacgctgtct      420

acaagaccct ggagtgagat aacgtgcctg gtactgtgcc ctgcatgtgt aagatgccca      480

gttgaccttc gcagcaggag cctggatcag ggcacttcct gcctcaggta ttgctggaca      540

gcccagacac ttccctctgt gaccatgaaa ctctgggtgt ctgcattgct gatggcctgg      600

tttggtgtcc tgagctgtgt gcaggccgaa ttcttcacct ctattgggca catgactgac      660

ctgatttatg cagagaaaga gctggtgcag tctctgaaag agtacatcct tgtggaggaa      720

gccaagcttt ccaagattaa gagctgggcc aacaaaatgg aagccttgac tagcaagtca      780

gctgctgatg ctgagggcta cctggctcac cctgtgaatg cctacaaact ggtgaagcgg      840

ctaaacacag actggcctgc gctggaggac cttgtcctgc aggactcagc tgcaggtttt      900

atcgccaacc tctctgtgca gcggcagttc ttccccactg atgaggacga gataggagct      960

gccaaagccc tgatgagact tcaggacaca tacaggctgg acccaggcac aatttccaga     1020

ggggaacttc caggaaccaa gtaccaggca atgctgagtg tggatgactg ctttgggatg     1080

ggccgctcgg cctacaatga aggggactat tatcatacgg tgttgtggat ggagcaggtg     1140

ctaaagcagc ttgatgccgg ggaggaggcc accacaacca agtcacaggt gctggactac     1200

ctcagctatg ctgtcttcca gttgggtgat ctgcaccgtg ccctggagct cacccgccgc     1260

ctgctctccc ttgacccaag ccacgaacga gctggaggga atctgcggta ctttgagcag     1320

ttattggagg aagagagaga aaaaacgtta acaaatcaga cagaagctga gctagcaacc     1380

ccagaaggca tctatgagag gcctgtggac tacctgcctg agagggatgt ttacgagagc     1440

ctctgtcgtg gggagggtgt caaactgaca ccccgtagac agaagaggct tttctgtagg     1500

taccaccatg gcaacagggc cccacagctg ctcattgccc ccttcaaaga ggaggacgag     1560

tgggacagcc cgcacatcgt caggtactac gatgtcatgt ctgatgagga aatcgagagg     1620

atcaaggaga tcgcaaaacc taaacttgca cgagccaccg ttcgtgatcc caagacagga     1680

gtcctcactg tcgccagcta ccgggtttcc aaaagctcct ggctagagga agatgatgac     1740

cctgttgtgg cccgagtaaa tcgtcggatg cagcatatca cagggttaac agtaaagact     1800

gcagaattgt tacaggttgc aaattatgga gtgggaggac agtatgaacc gcacttcgac     1860

ttctctaggc gaccttttga cagcggcctc aaaacagagg ggaataggtt agcgacgttt     1920

cttaactaca tgagtgatgt agaagctggt ggtgccaccg tcttccctga tctgggggct     1980

gcaatttggc ctaagaaggg tacagctgtg ttctggtaca acctcttgcg gagcggggaa     2040

ggtgactacc gaacaagaca tgctgcctgc cctgtgcttg tgggctgcaa gtgggtctcc     2100

aataagtggt tccatgaacg aggacaggag ttcttgagac cttgtggatc aacagaagtt     2160

gactgacatc cttttctgtc cttccccttc ctggtccttc agcccatgtc aacgtgacag     2220

acacctttgt atgttccttt gtatgttcct atcaggctga tttttggaga aatgaatgtt     2280

tgtctggagc agagggagac catactaggg cgactcctgt gtgactgaag tcccagccct     2340

tccattcagc ctgtgccatc cctggcccca aggctaggat caaagtggct gcagcagagt     2400

tagctgtcta gcgcctagca aggtgccttt gtacctcagg tgttttaggt gtgagatgtt     2460

tcagtgaacc aaagttctga taccttgttt acatgtttgt ttttatggca tttctatcta     2520

ttgtggcttt accaaaaaat aaaatgtccc taccagaagc cttaaaaaaa aaaaaaaaaa     2580

aa                                                                    2582


<210> 92
<211> 533
<212> PRT
<213> Homo sapiens

<400> 92
Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Arg Pro Phe Asp Ser Gly Leu Lys Thr Glu Gly Asn Arg 
        435                 440                 445             


Leu Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly Gly Ala 
    450                 455                 460                 


Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys Gly Thr 
465                 470                 475                 480 


Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp Tyr Arg 
                485                 490                 495     


Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp Val Ser 
            500                 505                 510         


Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro Cys Gly 
        515                 520                 525             


Ser Thr Glu Val Asp 
    530             


<210> 93
<211> 2110
<212> DNA
<213> Homo sapiens

<400> 93
aagggaggag gcgccgagct gaccgggcga cgccgcggga ggttctggaa acgccgggag       60

ctgcgagtgt ccagacactt ccctctgtga ccatgaaact ctgggtgtct gcattgctga      120

tggcctggtt tggtgtcctg agctgtgtgc aggccgaatt cttcacctct attgggcaca      180

tgactgacct gatttatgca gagaaagagc tggtgcagtc tctgaaagag tacatccttg      240

tggaggaagc caagctttcc aagattaaga gctgggccaa caaaatggaa gccttgacta      300

gcaagtcagc tgctgatgct gagggctacc tggctcaccc tgtgaatgcc tacaaactgg      360

tgaagcggct aaacacagac tggcctgcgc tggaggacct tgtcctgcag gactcagctg      420

caggttttat cgccaacctc tctgtgcagc ggcagttctt ccccactgat gaggacgaga      480

taggagctgc caaagccctg atgagacttc aggacacata caggctggac ccaggcacaa      540

tttccagagg ggaacttcca ggaaccaagt accaggcaat gctgagtgtg gatgactgct      600

ttgggatggg ccgctcggcc tacaatgaag gggactatta tcatacggtg ttgtggatgg      660

agcaggtgct aaagcagctt gatgccgggg aggaggccac cacaaccaag tcacaggtgc      720

tggactacct cagctatgct gtcttccagt tgggtgatct gcaccgtgcc ctggagctca      780

cccgccgcct gctctccctt gacccaagcc acgaacgagc tggagggaat ctgcggtact      840

ttgagcagtt attggaggaa gagagagaaa aaacgttaac aaatcagaca gaagctgagc      900

tagcaacccc agaaggcatc tatgagaggc ctgtggacta cctgcctgag agggatgttt      960

acgagagcct ctgtcgtggg gagggtgtca aactgacacc ccgtagacag aagaggcttt     1020

tctgtaggta ccaccatggc aacagggccc cacagctgct cattgccccc ttcaaagagg     1080

aggacgagtg ggacagcccg cacatcgtca ggtactacga tgtcatgtct gatgaggaaa     1140

tcgagaggat caaggagatc gcaaaaccta aacttgcacg agccaccgtt cgtgatccca     1200

agacaggagt cctcactgtc gccagctacc gggtttccaa aagctcctgg ctagaggaag     1260

atgatgaccc tgttgtggcc cgagtaaatc gtcggatgca gcatatcaca gggttaacag     1320

taaagactgc agaattgtta caggttgcaa attatggagt gggaggacag tatgaaccgc     1380

acttcgactt ctctaggcga ccttttgaca gcggcctcaa aacagagggg aataggttag     1440

cgacgtttct taactacatg agtgatgtag aagctggtgg tgccaccgtc ttccctgatc     1500

tgggggctgc aatttggcct aagaagggta cagctgtgtt ctggtacaac ctcttgcgga     1560

gcggggaagg tgactaccga acaagacatg ctgcctgccc tgtgcttgtg ggctgcaagt     1620

gggtctccaa taagtggttc catgaacgag gacaggagtt cttgagacct tgtggatcaa     1680

cagaagttga ctgacatcct tttctgtcct tccccttcct ggtccttcag cccatgtcaa     1740

cgtgacagac acctttgtat gttcctttgt atgttcctat caggctgatt tttggagaaa     1800

tgaatgtttg tctggagcag agggagacca tactagggcg actcctgtgt gactgaagtc     1860

ccagcccttc cattcagcct gtgccatccc tggccccaag gctaggatca aagtggctgc     1920

agcagagtta gctgtctagc gcctagcaag gtgcctttgt acctcaggtg ttttaggtgt     1980

gagatgtttc agtgaaccaa agttctgata ccttgtttac atgtttgttt ttatggcatt     2040

tctatctatt gtggctttac caaaaaataa aatgtcccta ccagaagcct taaaaaaaaa     2100

aaaaaaaaaa                                                            2110


<210> 94
<211> 533
<212> PRT
<213> Homo sapiens

<400> 94
Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Arg Pro Phe Asp Ser Gly Leu Lys Thr Glu Gly Asn Arg 
        435                 440                 445             


Leu Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly Gly Ala 
    450                 455                 460                 


Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys Gly Thr 
465                 470                 475                 480 


Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp Tyr Arg 
                485                 490                 495     


Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp Val Ser 
            500                 505                 510         


Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro Cys Gly 
        515                 520                 525             


Ser Thr Glu Val Asp 
    530             


<210> 95
<211> 2246
<212> DNA
<213> Homo sapiens

<400> 95
aagggaggag gcgccgagct gaccgggcga cgccgcggga ggttctggaa acgccgggag       60

ctgcgagtgt ccagctgcgg agacccgtga taattcgtta actaattcaa caaacgggac      120

ccttctgtgt gccagaaacc gcaagcagtt gctaacccag tgggacaggc ggattggaag      180

agcgggaagg tcctggccca gagcagtgtg acacttccct ctgtgaccat gaaactctgg      240

gtgtctgcat tgctgatggc ctggtttggt gtcctgagct gtgtgcaggc cgaattcttc      300

acctctattg ggcacatgac tgacctgatt tatgcagaga aagagctggt gcagtctctg      360

aaagagtaca tccttgtgga ggaagccaag ctttccaaga ttaagagctg ggccaacaaa      420

atggaagcct tgactagcaa gtcagctgct gatgctgagg gctacctggc tcaccctgtg      480

aatgcctaca aactggtgaa gcggctaaac acagactggc ctgcgctgga ggaccttgtc      540

ctgcaggact cagctgcagg ttttatcgcc aacctctctg tgcagcggca gttcttcccc      600

actgatgagg acgagatagg agctgccaaa gccctgatga gacttcagga cacatacagg      660

ctggacccag gcacaatttc cagaggggaa cttccaggaa ccaagtacca ggcaatgctg      720

agtgtggatg actgctttgg gatgggccgc tcggcctaca atgaagggga ctattatcat      780

acggtgttgt ggatggagca ggtgctaaag cagcttgatg ccggggagga ggccaccaca      840

accaagtcac aggtgctgga ctacctcagc tatgctgtct tccagttggg tgatctgcac      900

cgtgccctgg agctcacccg ccgcctgctc tcccttgacc caagccacga acgagctgga      960

gggaatctgc ggtactttga gcagttattg gaggaagaga gagaaaaaac gttaacaaat     1020

cagacagaag ctgagctagc aaccccagaa ggcatctatg agaggcctgt ggactacctg     1080

cctgagaggg atgtttacga gagcctctgt cgtggggagg gtgtcaaact gacaccccgt     1140

agacagaaga ggcttttctg taggtaccac catggcaaca gggccccaca gctgctcatt     1200

gcccccttca aagaggagga cgagtgggac agcccgcaca tcgtcaggta ctacgatgtc     1260

atgtctgatg aggaaatcga gaggatcaag gagatcgcaa aacctaaact tgcacgagcc     1320

accgttcgtg atcccaagac aggagtcctc actgtcgcca gctaccgggt ttccaaaagc     1380

tcctggctag aggaagatga tgaccctgtt gtggcccgag taaatcgtcg gatgcagcat     1440

atcacagggt taacagtaaa gactgcagaa ttgttacagg ttgcaaatta tggagtggga     1500

ggacagtatg aaccgcactt cgacttctct aggcgacctt ttgacagcgg cctcaaaaca     1560

gaggggaata ggttagcgac gtttcttaac tacatgagtg atgtagaagc tggtggtgcc     1620

accgtcttcc ctgatctggg ggctgcaatt tggcctaaga agggtacagc tgtgttctgg     1680

tacaacctct tgcggagcgg ggaaggtgac taccgaacaa gacatgctgc ctgccctgtg     1740

cttgtgggct gcaagtgggt ctccaataag tggttccatg aacgaggaca ggagttcttg     1800

agaccttgtg gatcaacaga agttgactga catccttttc tgtccttccc cttcctggtc     1860

cttcagccca tgtcaacgtg acagacacct ttgtatgttc ctttgtatgt tcctatcagg     1920

ctgatttttg gagaaatgaa tgtttgtctg gagcagaggg agaccatact agggcgactc     1980

ctgtgtgact gaagtcccag cccttccatt cagcctgtgc catccctggc cccaaggcta     2040

ggatcaaagt ggctgcagca gagttagctg tctagcgcct agcaaggtgc ctttgtacct     2100

caggtgtttt aggtgtgaga tgtttcagtg aaccaaagtt ctgatacctt gtttacatgt     2160

ttgtttttat ggcatttcta tctattgtgg ctttaccaaa aaataaaatg tccctaccag     2220

aagccttaaa aaaaaaaaaa aaaaaa                                          2246


<210> 96
<211> 533
<212> PRT
<213> Homo sapiens

<400> 96
Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Arg Pro Phe Asp Ser Gly Leu Lys Thr Glu Gly Asn Arg 
        435                 440                 445             


Leu Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly Gly Ala 
    450                 455                 460                 


Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys Gly Thr 
465                 470                 475                 480 


Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp Tyr Arg 
                485                 490                 495     


Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp Val Ser 
            500                 505                 510         


Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro Cys Gly 
        515                 520                 525             


Ser Thr Glu Val Asp 
    530             


<210> 97
<211> 2252
<212> DNA
<213> Homo sapiens

<400> 97
aagggaggag gcgccgagct gaccgggcga cgccgcggga ggttctggaa acgccgggag       60

ctgcgagtgt ccagctgcgg agacccgtga taattcgtta actaattcaa caaacgggac      120

ccttctgtgt gccagaaacc gcaagcagtt gctaacccag tgggacaggc ggattggaag      180

agcgggaagg tcctggccca gagcagtgtg acacttccct ctgtgaccat gaaactctgg      240

gtgtctgcat tgctgatggc ctggtttggt gtcctgagct gtgtgcaggc cgaattcttc      300

acctctattg ggcacatgac tgacctgatt tatgcagaga aagagctggt gcagtctctg      360

aaagagtaca tccttgtgga ggaagccaag ctttccaaga ttaagagctg ggccaacaaa      420

atggaagcct tgactagcaa gtcagctgct gatgctgagg gctacctggc tcaccctgtg      480

aatgcctaca aactggtgaa gcggctaaac acagactggc ctgcgctgga ggaccttgtc      540

ctgcaggact cagctgcagg ttttatcgcc aacctctctg tgcagcggca gttcttcccc      600

actgatgagg acgagatagg agctgccaaa gccctgatga gacttcagga cacatacagg      660

ctggacccag gcacaatttc cagaggggaa cttccaggaa ccaagtacca ggcaatgctg      720

agtgtggatg actgctttgg gatgggccgc tcggcctaca atgaagggga ctattatcat      780

acggtgttgt ggatggagca ggtgctaaag cagcttgatg ccggggagga ggccaccaca      840

accaagtcac aggtgctgga ctacctcagc tatgctgtct tccagttggg tgatctgcac      900

cgtgccctgg agctcacccg ccgcctgctc tcccttgacc caagccacga acgagctgga      960

gggaatctgc ggtactttga gcagttattg gaggaagaga gagaaaaaac gttaacaaat     1020

cagacagaag ctgagctagc aaccccagaa ggcatctatg agaggcctgt ggactacctg     1080

cctgagaggg atgtttacga gagcctctgt cgtggggagg gtgtcaaact gacaccccgt     1140

agacagaaga ggcttttctg taggtaccac catggcaaca gggccccaca gctgctcatt     1200

gcccccttca aagaggagga cgagtgggac agcccgcaca tcgtcaggta ctacgatgtc     1260

atgtctgatg aggaaatcga gaggatcaag gagatcgcaa aacctaaact tgcacgagcc     1320

accgttcgtg atcccaagac aggagtcctc actgtcgcca gctaccgggt ttccaaaagc     1380

tcctggctag aggaagatga tgaccctgtt gtggcccgag taaatcgtcg gatgcagcat     1440

atcacagggt taacagtaaa gactgcagaa ttgttacagg ttgcaaatta tggagtggga     1500

ggacagtatg aaccgcactt cgacttctct aggaatgatg agcgagatac tttcaagcat     1560

ttagggacgg ggaatcgtgt ggctactttc ttaaactaca tgagtgatgt agaagctggt     1620

ggtgccaccg tcttccctga tctgggggct gcaatttggc ctaagaaggg tacagctgtg     1680

ttctggtaca acctcttgcg gagcggggaa ggtgactacc gaacaagaca tgctgcctgc     1740

cctgtgcttg tgggctgcaa gtgggtctcc aataagtggt tccatgaacg aggacaggag     1800

ttcttgagac cttgtggatc aacagaagtt gactgacatc cttttctgtc cttccccttc     1860

ctggtccttc agcccatgtc aacgtgacag acacctttgt atgttccttt gtatgttcct     1920

atcaggctga tttttggaga aatgaatgtt tgtctggagc agagggagac catactaggg     1980

cgactcctgt gtgactgaag tcccagccct tccattcagc ctgtgccatc cctggcccca     2040

aggctaggat caaagtggct gcagcagagt tagctgtcta gcgcctagca aggtgccttt     2100

gtacctcagg tgttttaggt gtgagatgtt tcagtgaacc aaagttctga taccttgttt     2160

acatgtttgt ttttatggca tttctatcta ttgtggcttt accaaaaaat aaaatgtccc     2220

taccagaagc cttaaaaaaa aaaaaaaaaa aa                                   2252


<210> 98
<211> 535
<212> PRT
<213> Homo sapiens

<400> 98
Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Asn Asp Glu Arg Asp Thr Phe Lys His Leu Gly Thr Gly 
        435                 440                 445             


Asn Arg Val Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly 
    450                 455                 460                 


Gly Ala Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys 
465                 470                 475                 480 


Gly Thr Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp 
                485                 490                 495     


Tyr Arg Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp 
            500                 505                 510         


Val Ser Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro 
        515                 520                 525             


Cys Gly Ser Thr Glu Val Asp 
    530                 535 


<210> 99
<211> 2097
<212> DNA
<213> Homo sapiens

<400> 99
ggtccttcag cctcgttccc gggcagtata aagtttgctg tctcctttgt tcgccctcgt       60

tgcgcagtag tgctagcggc ttcgcggttc ggtcctcgca cccggcagcc gccactggtg      120

ctgagctgct aggaagcccc tatcgccgag ctcgttggag cttgaaccca ttgtcacccc      180

tccgactcac cggcccaaaa aaaaaaaaac atggttgaag cagatcgccc aggaaagctc      240

ttcattggtg ggcttaatac ggaaacaaat gagaaagctc ttgaagcagt atttggcaaa      300

tatggacgaa tagtggaagt actcttgatg aaagaccgtg aaaccaacaa atcaagagga      360

tttgcttttg tcacctttga aagcccagca gacgctaagg atgcagccag agacatgaat      420

ggaaagtcat tagatggaaa agccatcaag gtggaacaag ccaccaaacc atcatttgaa      480

agtggtagac gtggaccgcc tccacctcca agaagtagag gccctccaag aggtcttaga      540

ggtggaagag gaggaagtgg aggaaccagg ggacctccct cacggggagg acacatggat      600

gacggtggat attccatgaa ttttaacatg agttcttcca ggggaccact cccagtaaaa      660

agaggaccac caccaagaag tgggggtcct cctcctaaga gatctgcacc ttcaggacca      720

gttcgcagta gcagtggaat gggaggaaga gctcctgtat cacgtggaag agatagttat      780

ggaggtccac ctcgaaggga accgctgccc tctcgtagag atgtttattt gtccccaaga      840

gatgatgggt attctactaa agacagctat tcaagcagag attacccaag ttctcgtgat      900

actagagatt atgcaccacc accacgagat tatacttacc gtgattatgg tcattccagt      960

tcacgtgatg actatccatc aagaggatat agcgatagag atggatatgg tcgtgatcgt     1020

gactattcag atcatccaag tggaggttcc tacagagatt catatgagag ttatggtaac     1080

tcacgtagtg ctccacctac acgagggccc ccgccatctt atggtggaag cagtcgctat     1140

gatgattaca gcagctcacg tgacggatat ggtggaagtc gagacagtta ctcaagcagc     1200

cgaagtgatc tctactcaag tggtcgtgat cgggttggca gacaagaaag agggcttccc     1260

ccttctatgg aaagggggta ccctcctcca cgtgattcct acagcagttc aagccgcgga     1320

gcaccaagag gtggtggccg tggaggaagc cgatctgata gagggggagg cagaagcaga     1380

tactagaaac aaacaaaact ttggaccaaa atcccagttc aaagaaacaa aaagtggaaa     1440

ctattctatc ataactaccc aaggactact aaaaggaaaa attgtgttac tttttttaaa     1500

ttccctgtta agttcccctc cataattttt atgttcttgt gaggaaaaaa gtaaaacatg     1560

tttaatttta tttgactttc gcattgcttt tcaacaagca aatgttaaat gtgttaagac     1620

ttgtactagt gttgtaactt tccaagtaaa agtatcccct aaaggccact tcctatctga     1680

tttttcccag caaatgaggc aggcaattct aagatcttcc acaaaacatc tagccatcta     1740

aaatggagag atgaatcatt ctacctatac aaacaagcta gctattagag ggtggttggg     1800

gtatgctact cataagattt cagggtgtct tccaactgaa atctcaatgt tctcagtacg     1860

aaaaacctga aatcacatgc ctatgtaagg aaagtgctat tcacccagta aacccaaaaa     1920

agcaaatgga taatgctggc cattttgcct ttctgacatt tccttgggaa tctgcaagaa     1980

cctccccttt cccttccccc aataagacca tttaagtgtg tgttaaacaa ctacagaata     2040

ctaaataaaa agtttggcca aaaccaacca tgaagctgca aaaaaaaaaa aaaaaaa        2097


<210> 100
<211> 391
<212> PRT
<213> Homo sapiens

<400> 100
Met Val Glu Ala Asp Arg Pro Gly Lys Leu Phe Ile Gly Gly Leu Asn 
1               5                   10                  15      


Thr Glu Thr Asn Glu Lys Ala Leu Glu Ala Val Phe Gly Lys Tyr Gly 
            20                  25                  30          


Arg Ile Val Glu Val Leu Leu Met Lys Asp Arg Glu Thr Asn Lys Ser 
        35                  40                  45              


Arg Gly Phe Ala Phe Val Thr Phe Glu Ser Pro Ala Asp Ala Lys Asp 
    50                  55                  60                  


Ala Ala Arg Asp Met Asn Gly Lys Ser Leu Asp Gly Lys Ala Ile Lys 
65                  70                  75                  80  


Val Glu Gln Ala Thr Lys Pro Ser Phe Glu Ser Gly Arg Arg Gly Pro 
                85                  90                  95      


Pro Pro Pro Pro Arg Ser Arg Gly Pro Pro Arg Gly Leu Arg Gly Gly 
            100                 105                 110         


Arg Gly Gly Ser Gly Gly Thr Arg Gly Pro Pro Ser Arg Gly Gly His 
        115                 120                 125             


Met Asp Asp Gly Gly Tyr Ser Met Asn Phe Asn Met Ser Ser Ser Arg 
    130                 135                 140                 


Gly Pro Leu Pro Val Lys Arg Gly Pro Pro Pro Arg Ser Gly Gly Pro 
145                 150                 155                 160 


Pro Pro Lys Arg Ser Ala Pro Ser Gly Pro Val Arg Ser Ser Ser Gly 
                165                 170                 175     


Met Gly Gly Arg Ala Pro Val Ser Arg Gly Arg Asp Ser Tyr Gly Gly 
            180                 185                 190         


Pro Pro Arg Arg Glu Pro Leu Pro Ser Arg Arg Asp Val Tyr Leu Ser 
        195                 200                 205             


Pro Arg Asp Asp Gly Tyr Ser Thr Lys Asp Ser Tyr Ser Ser Arg Asp 
    210                 215                 220                 


Tyr Pro Ser Ser Arg Asp Thr Arg Asp Tyr Ala Pro Pro Pro Arg Asp 
225                 230                 235                 240 


Tyr Thr Tyr Arg Asp Tyr Gly His Ser Ser Ser Arg Asp Asp Tyr Pro 
                245                 250                 255     


Ser Arg Gly Tyr Ser Asp Arg Asp Gly Tyr Gly Arg Asp Arg Asp Tyr 
            260                 265                 270         


Ser Asp His Pro Ser Gly Gly Ser Tyr Arg Asp Ser Tyr Glu Ser Tyr 
        275                 280                 285             


Gly Asn Ser Arg Ser Ala Pro Pro Thr Arg Gly Pro Pro Pro Ser Tyr 
    290                 295                 300                 


Gly Gly Ser Ser Arg Tyr Asp Asp Tyr Ser Ser Ser Arg Asp Gly Tyr 
305                 310                 315                 320 


Gly Gly Ser Arg Asp Ser Tyr Ser Ser Ser Arg Ser Asp Leu Tyr Ser 
                325                 330                 335     


Ser Gly Arg Asp Arg Val Gly Arg Gln Glu Arg Gly Leu Pro Pro Ser 
            340                 345                 350         


Met Glu Arg Gly Tyr Pro Pro Pro Arg Asp Ser Tyr Ser Ser Ser Ser 
        355                 360                 365             


Arg Gly Ala Pro Arg Gly Gly Gly Arg Gly Gly Ser Arg Ser Asp Arg 
    370                 375                 380                 


Gly Gly Gly Arg Ser Arg Tyr 
385                 390     


<210> 101
<211> 2071
<212> DNA
<213> Homo sapiens

<400> 101
ggtccttcag cctcgttccc gggcagtata aagtttgctg tctcctttgt tcgccctcgt       60

tgcgcagtag tgctagcggc ttcgcggttc ggtcctcgca cccggcagcc gccactggtg      120

ctgagctgct aggaagcccc tatcgccgag ctcgttggag cttgaaccca ttgtcacccc      180

tccgactcac cggcccaaaa aaaaaaaaac atggttgaag cagatcgccc aggaaagctc      240

ttcattggtg ggcttaatac ggaaacaaat gagaaagctc ttgaagcagt atttggcaaa      300

tatggacgaa tagtggaagt actcttgatg aaagaccgtg aaaccaacaa atcaagagga      360

tttgcttttg tcacctttga aagcccagca gacgctaagg atgcagccag agacatgaat      420

ggaaagctcc tgtatcacgt ggaagagata gttatggagg tccacctcga agggaaccgc      480

tgccctctcg tagagatgtt tatttgtccc caagagatga tgggtattct actaaagaca      540

gctattcaag cagagattac ccaagttctc gtgatactag agattatgca ccaccaccac      600

gagattatac ttaccgtgat tatggtcatt ccagttcacg tgatgactat ccatcaagag      660

gatatagcga tagagatgga tatggtcgtg atcgtgacta ttcagatcat ccaagtggag      720

gttcctacag agattcatat gagagttatg gttggtgatt ttgctcatta tggtcgtgga      780

gtgctgattg attcacagta gataaagctg gcagtaagaa atgctaagag ttgttgaagc      840

agaaggcggc tgattgtcaa taagtcacta cagttgcata agcagtgctg tcagaattgg      900

tttggtgcag gcaatagatt ttgccttcag gggttcctgt ggatctgagg aaggcatcag      960

tgttgattaa cactcataac tagggagtga ctggtagtta cttaaagcaa gtaattgacc     1020

aaatggaaaa ggggaagtaa ttaaggaaat tggtaagtgg aggtagtcag gaagttcttg     1080

tggttcttca catagatttt acagctttgg ctttcatttt gtttagctaa agtcatgggg     1140

acaactcttc aatttagaac ttaagttgaa ttataaaaat gatggatata agtggtagct     1200

gtatctagtg aagtgtctgt cagtaagtga aacatttttt ggtggtggct tatccacaaa     1260

cagtttagtt gtagaataaa acttatgagt gacatctgga aagtaaccat gctaagatgg     1320

caagcacact ggaaacaatt aggccacttg gctttctttt gctgtattgt tttataagcc     1380

tactttacct cccagtcttg gaaacaagtt ttagtttttt attggtttgg agactagagc     1440

caatagtata atgttctcaa aggaaacaga cttgagttgt tggattagag gaactaaccc     1500

aacttatatg attttttttt tgtttttgtc gtgtagttat ggcactgtct tatttggaac     1560

atttgcaact agggataata caacattttt aactctcatt tgacaaccta ctactaatca     1620

cagaccacaa gggtaatgac caaatttatg tggtttttgc actccatagt tgtcttagcc     1680

caatctttct atactcttac gattacttgg gttaacgctt ctgtgaggac cttctggctc     1740

ttgagatacc ctaaatattt aagatattta gatatcttga agatagtata ggatatagag     1800

attgtaccaa ataggaatat aaggagtatg ttaaaatgac cagatacctg tttgatagtt     1860

tactgaccta gcagatgtgt ggaaaaggaa tcagatcttg attcttctgg gtttatactg     1920

gttgtaaaac agaatgatac agaaaatgtt ttccttgttt aactggtagt tgaacataga     1980

acttgggtat tatagatcac ttttcacttt ttggaatgtt ttgtattgaa acttaataaa     2040

actttaacat ggaaaaaaaa aaaaaaaaaa a                                    2071


<210> 102
<211> 196
<212> PRT
<213> Homo sapiens

<400> 102
Met Val Glu Ala Asp Arg Pro Gly Lys Leu Phe Ile Gly Gly Leu Asn 
1               5                   10                  15      


Thr Glu Thr Asn Glu Lys Ala Leu Glu Ala Val Phe Gly Lys Tyr Gly 
            20                  25                  30          


Arg Ile Val Glu Val Leu Leu Met Lys Asp Arg Glu Thr Asn Lys Ser 
        35                  40                  45              


Arg Gly Phe Ala Phe Val Thr Phe Glu Ser Pro Ala Asp Ala Lys Asp 
    50                  55                  60                  


Ala Ala Arg Asp Met Asn Gly Lys Leu Leu Tyr His Val Glu Glu Ile 
65                  70                  75                  80  


Val Met Glu Val His Leu Glu Gly Asn Arg Cys Pro Leu Val Glu Met 
                85                  90                  95      


Phe Ile Cys Pro Gln Glu Met Met Gly Ile Leu Leu Lys Thr Ala Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Val Leu Val Ile Leu Glu Ile Met His His 
        115                 120                 125             


His His Glu Ile Ile Leu Thr Val Ile Met Val Ile Pro Val His Val 
    130                 135                 140                 


Met Thr Ile His Gln Glu Asp Ile Ala Ile Glu Met Asp Met Val Val 
145                 150                 155                 160 


Ile Val Thr Ile Gln Ile Ile Gln Val Glu Val Pro Thr Glu Ile His 
                165                 170                 175     


Met Arg Val Met Val Gly Asp Phe Ala His Tyr Gly Arg Gly Val Leu 
            180                 185                 190         


Ile Asp Ser Gln 
        195     


<210> 103
<211> 1137
<212> DNA
<213> Homo sapiens

<400> 103
actcgcgccc ttgccgctgc caccgcaccc cgccatggag cggccgtcgc tgcgcgccct       60

gctcctcggc gccgctgggc tgctgctcct gctcctgccc ctctcctctt cctcctcttc      120

ggacacctgc ggcccctgcg agccggcctc ctgcccgccc ctgcccccgc tgggctgcct      180

gctgggcgag acccgcgacg cgtgcggctg ctgccctatg tgcgcccgcg gcgagggcga      240

gccgtgcggg ggtggcggcg ccggcagggg gtactgcgcg ccgggcatgg agtgcgtgaa      300

gagccgcaag aggcggaagg gtaaagccgg ggcagcagcc ggcggtccgg gtgtaagcgg      360

cgtgtgcgtg tgcaagagcc gctacccggt gtgcggcagc gacggcacca cctacccgag      420

cggctgccag ctgcgcgccg ccagccagag ggccgagagc cgcggggaga aggccatcac      480

ccaggtcagc aagggcacct gcgagcaagg tccttccata gtgacgcccc ccaaggacat      540

ctggaatgtc actggtgccc aggtgtactt gagctgtgag gtcatcggaa tcccgacacc      600

tgtcctcatc tggaacaagg taaaaagggg tcactatgga gttcaaagga cagaactcct      660

gcctggtgac cgggacaacc tggccattca gacccggggt ggcccagaaa agcatgaagt      720

aactggctgg gtgctggtat ctcctctaag taaggaagat gctggagaat atgagtgcca      780

tgcatccaat tcccaaggac aggcttcagc atcagcaaaa attacagtgg ttgatgcctt      840

acatgaaata ccagtgaaaa aaggtgaagg tgccgagcta taaacctcca gaatattatt      900

agtctgcatg gttaaaagta gtcatggata actacattac ctgttcttgc ctaataagtt      960

tcttttaatc caatccacta acactttagt tatattcact ggttttacac agagaaatac     1020

aaaataaaga tcacacatca agactatcta caaaaattta ttatatattt acagaagaaa     1080

agcatgcata tcattaaaca aataaaatac tttttatcac aacacagtaa aaaaaaa        1137


<210> 104
<211> 282
<212> PRT
<213> Homo sapiens

<400> 104
Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Glu Gly Ala Glu Leu 
        275                 280         


<210> 105
<211> 1051
<212> DNA
<213> Homo sapiens

<400> 105
actcgcgccc ttgccgctgc caccgcaccc cgccatggag cggccgtcgc tgcgcgccct       60

gctcctcggc gccgctgggc tgctgctcct gctcctgccc ctctcctctt cctcctcttc      120

ggacacctgc ggcccctgcg agccggcctc ctgcccgccc ctgcccccgc tgggctgcct      180

gctgggcgag acccgcgacg cgtgcggctg ctgccctatg tgcgcccgcg gcgagggcga      240

gccgtgcggg ggtggcggcg ccggcagggg gtactgcgcg ccgggcatgg agtgcgtgaa      300

gagccgcaag aggcggaagg gtaaagccgg ggcagcagcc ggcggtccgg gtgtaagcgg      360

cgtgtgcgtg tgcaagagcc gctacccggt gtgcggcagc gacggcacca cctacccgag      420

cggctgccag ctgcgcgccg ccagccagag ggccgagagc cgcggggaga aggccatcac      480

ccaggtcagc aagggcacct gcgagcaagg tccttccata gtgacgcccc ccaaggacat      540

ctggaatgtc actggtgccc aggtgtactt gagctgtgag gtcatcggaa tcccgacacc      600

tgtcctcatc tggaacaagg taaaaagggg tcactatgga gttcaaagga cagaactcct      660

gcctggtgac cgggacaacc tggccattca gacccggggt ggcccagaaa agcatgaagt      720

aactggctgg gtgctggtat ctcctctaag taaggaagat gctggagaat atgagtgcca      780

tgcatccaat tcccaaggac aggcttcagc atcagcaaaa attacagtgg ttgatgcctt      840

acatgaaata ccagtgaaaa aaggtacaca ataaatctca cagccattta aaaatgacta      900

gtacatttgc tttaaaaaga acagaactaa gtatgaaagt atcagacgta gctattgatg      960

aaattctgta gttagcaacc cataagggca ttaagtatgc cattaaaatg tacagcatga     1020

gactccaaaa gattatctgg atgggtgact g                                    1051


<210> 106
<211> 279
<212> PRT
<213> Homo sapiens

<400> 106
Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Thr Gln 
        275                 


<210> 107
<211> 1586
<212> DNA
<213> Homo sapiens

<400> 107
tccgcagtcc cggttctaaa gtccccagtc acccacccgg actcacattc tccccagagg       60

ccgagatgcg ggtcatggcg ccccgagccc tcctcctgct gctctcggga ggcctggccc      120

tgaccgagac ctgggcctgc tcccactcca tgaggtattt cgacaccgcc gtgtcccggc      180

ccggccgcgg agagccccgc ttcatctcag tgggctacgt ggacgacacg cagttcgtgc      240

ggttcgacag cgacgccgcg agtccgagag gggagccgcg ggcgccgtgg gtggagcagg      300

aggggccgga gtattgggac cgggagacac agaagtacaa gcgccaggca caggctgacc      360

gagtgagcct gcggaacctg cgcggctact acaaccagag cgaggacggg tctcacaccc      420

tccagaggat gtctggctgc gacctggggc ccgacgggcg cctcctccgc gggtatgacc      480

agtccgccta cgacggcaag gattacatcg ccctgaacga ggacctgcgc tcctggaccg      540

ccgcggacac cgcggctcag atcacccagc gcaagttgga ggcggcccgt gcggcggagc      600

agctgagagc ctacctggag ggcacgtgcg tggagtggct ccgcagatac ctggagaacg      660

ggaaggagac gctgcagcgc gcagaacccc caaagacaca cgtgacccac caccccctct      720

ctgaccatga ggccaccctg aggtgctggg ccctgggctt ctaccctgcg gagatcacac      780

tgacctggca gcgggatggg gaggaccaga cccaggacac cgagcttgtg gagaccaggc      840

cagcaggaga tggaaccttc cagaagtggg cagctgtggt ggtgccttct ggacaagagc      900

agagatacac gtgccatatg cagcacgagg ggctgcaaga gcccctcacc ctgagctggg      960

agccatcttc ccagcccacc atccccatca tgggcatcgt tgctggcctg gctgtcctgg     1020

ttgtcctagc tgtccttgga gctgtggtca ccgctatgat gtgtaggagg aagagctcag     1080

gtggaaaagg agggagctgc tctcaggctg cgtgcagcaa cagtgcccag ggctctgatg     1140

agtctctcat cacttgtaaa gcctgagaca gctgcctgtg tgggactgag atgcaggatt     1200

tcttcacacc tctcctttgt gacttcaaga gcctctggca tctctttctg caaaggcacc     1260

tgaatgtgtc tgcgttcctg ttagcataat gtgaggaggt ggagagacag cccacccccg     1320

tgtccaccgt gacccctgtc cccacactga cctgtgttcc ctccccgatc atctttcctg     1380

ttccagagag gtggggctgg atgtctccat ctctgtctca aattcatggt gcactgagct     1440

gcaacttctt acttccctaa tgaagttaag aacctgaata taaatttgtg ttctcaaata     1500

tttgctatga agcgttgatg gattaattaa ataagtcaat tcctagaagt tgagagagca     1560

aataaagacc tgagaacctt ccagaa                                          1586


<210> 108
<211> 366
<212> PRT
<213> Homo sapiens

<400> 108
Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Ser Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 
        355                 360                 365     


<210> 109
<211> 1586
<212> DNA
<213> Homo sapiens

<400> 109
tccgcagtcc cggttctaaa gtccccagtc acccacccgg actcacattc tccccagagg       60

ccgagatgcg ggtcatggcg ccccgagccc tcctcctgct gctctcggga ggcctggccc      120

tgaccgagac ctgggcctgc tcccactcca tgaggtattt cgacaccgcc gtgtcccggc      180

ccggccgcgg agagccccgc ttcatctcag tgggctacgt ggacgacacg cagttcgtgc      240

ggttcgacag cgacgccgcg agtccgagag gggagccgcg ggcgccgtgg gtggagcagg      300

aggggccgga gtattgggac cgggagacac agaactacaa gcgccaggca caggctgacc      360

gagtgagcct gcggaacctg cgcggctact acaaccagag cgaggacggg tctcacaccc      420

tccagaggat gtatggctgc gacctggggc ccgacgggcg cctcctccgc gggtatgacc      480

agtccgccta cgacggcaag gattacatcg ccctgaacga ggacctgcgc tcctggaccg      540

ccgcggacac cgcggctcag atcacccagc gcaagttgga ggcggcccgt gcggcggagc      600

agctgagagc ctacctggag ggcacgtgcg tggagtggct ccgcagatac ctggagaacg      660

ggaaggagac gctgcagcgc gcagaacccc caaagacaca cgtgacccac caccccctct      720

ctgaccatga ggccaccctg aggtgctggg ccctgggctt ctaccctgcg gagatcacac      780

tgacctggca gcgggatggg gaggaccaga cccaggacac cgagcttgtg gagaccaggc      840

cagcaggaga tggaaccttc cagaagtggg cagctgtggt ggtgccttct ggacaagagc      900

agagatacac gtgccatatg cagcacgagg ggctgcaaga gcccctcacc ctgagctggg      960

agccatcttc ccagcccacc atccccatca tgggcatcgt tgctggcctg gctgtcctgg     1020

ttgtcctagc tgtccttgga gctgtggtca ccgctatgat gtgtaggagg aagagctcag     1080

gtggaaaagg agggagctgc tctcaggctg cgtgcagcaa cagtgcccag ggctctgatg     1140

agtctctcat cacttgtaaa gcctgagaca gctgcctgtg tgggactgag atgcaggatt     1200

tcttcacacc tctcctttgt gacttcaaga gcctctggca tctctttctg caaaggcgtc     1260

tgaatgtgtc tgcgttcctg ttagcataat gtgaggaggt ggagagacag cccacccccg     1320

tgtccaccgt gacccctgtc cccacactga cctgtgttcc ctccccgatc atctttcctg     1380

ttccagagag gtggggctgg atgtctccat ctctgtctca aattcatggt gcactgagct     1440

gcaacttctt acttccctaa tgaagttaag aacctgaata taaatttgtg ttctcaaata     1500

tttgctatga agcgttgatg gattaattaa ataagtcaat tcctagaagt tgagagagca     1560

aataaagacc tgagaacctt ccagaa                                          1586


<210> 110
<211> 366
<212> PRT
<213> Homo sapiens

<400> 110
Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Asn Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 
        355                 360                 365     


<210> 111
<211> 2360
<212> DNA
<213> Homo sapiens

<400> 111
cagacggcca tttgtggcgg cgctggaggc tgcgttcggc aggcgctgcg gagacgcgta       60

gaggagcgcg ccccccggcc gctgccgccc ctggcccgtg ccgtcacccc gcttctccgc      120

gcctcgggcg gtacccagcc agtccccagc gccgcgctac cgcgctgacc ggccctccag      180

acgcctcccg gtacccggga ccccagcccg gccgctcgcc cgcagcccgc cggccgcaca      240

cgtccccgga gccgggccta gggcgggcgg cagcggcggc tcggcgcagt caggctgggc      300

tctgtagcgt ccccatggcc gcggccggct ggcgggacgg ctccggccag gagaagtacc      360

ggctcgtggt ggtcggcggg ggcggcgtgg gcaagtcggc gctcaccatc cagttcatcc      420

agtcctattt tgtaacggat tatgatccaa ccattgaaga ttcttacaca aagcagtgtg      480

tgatagatga cagagcagcc cggctagata ttttggatac agcaggacaa gaagagtttg      540

gagccatgag agaacagtat atgaggactg gcgaaggctt cctgttggtc ttttcagtca      600

cagatagagg cagttttgaa gaaatctata agtttcaaag acagattctc agagtaaagg      660

atcgtgatga gttcccaatg attttaattg gtaataaagc agatctggat catcaaagac      720

aggtaacaca ggaagaagga caacagttag cacggcagct taaggtaaca tacatggagg      780

catcagcaaa gattaggatg aatgtagatc aagctttcca tgaacttgtc cgggttatca      840

ggaaatttca agagcaggaa tgtcctcctt caccagaacc aacacggaaa gaaaaagaca      900

agaaaggctg ccattgtgtc attttctaga atcccttcag ttttagctac caacggccag      960

gaaaagccct catcttctct ttctctcctc agtttacatc ttgttggtac ctttctagcc     1020

ttagacaaat gatcaccatg ttagccttag acgaagaagc tggctagtcc tttctgtgaa     1080

gctaatacaa tggtcatttc cagacaaatt taaaggaaac actaaggctg cttcaaagat     1140

tatctgattc ctttaaaata tatgtctata tacacagaca tgctcttttt ttaagtgctt     1200

acattttaat agagatgaat cagttttgga atctaagctg tttgccaagc tgaagctaca     1260

ggttgtgaaa taatttttaa cttttggaat catactgcct actgttactc taaatagaaa     1320

tatagggttt tttttaatgt gaatttttgc ctatctttaa acatttcaat gtcagccttt     1380

gttaacctta aatacactga attgaatcta caaaagtgaa ccatctcaga cctttactga     1440

tactacaact tttgttttct gatggccaaa ataccaaatg cctgttgtat ttatggatta     1500

aaaactgctt ataaaaccct gtgttactac tcctactctt ggagatgata atattctatg     1560

tggtcaaata tttggactca tttaggactt agatatttca gtgtacttga ttttttaatt     1620

taactctttt tcacagccac gctaagggta aaaaggaata atttccttct gtcttccttt     1680

tcaagtattt ctgggtaagg gattcaaaaa actaaaactg tttttgtttg taatataaaa     1740

tatggaattg atctttccag ggtcagagat gattaatgtt tttgctatat acttttatac     1800

attattttct tatcaaacta gttaacaagt atttttatat gtttgtaagc agatatgctt     1860

tcatagcata ccttgtgtat atgtaaagat aagtatttaa ttctcactgt tcacttttaa     1920

ctgacaaaga aaaacaagtg gaaactacag aaactgtggt agaactttta cttgctggtc     1980

tggtcttggt tgtacccatc tttggccagt cacataacta ctcaagaaac cttcccaata     2040

gagtacaaca ggatgagact ctgaaatcac tttcagtatt ccctgctaga tattgattgt     2100

tatttcaagt attaagtgta agcttttaat ggataattag tataactgtg gatggcatct     2160

gattttgttt ttaattctgt ggattgtgtt taagcaattc aatagtatgt tcctgatttt     2220

gagatgctaa gtggtattgc acagttgtca ctttatcaag tgtgtacaac agtcccatga     2280

agtttataga gcataccctt gtatagcttc aggtgctaga attaaaattg atctgttatc     2340

acaagaaaaa aaaaaaaaaa                                                 2360


<210> 112
<211> 204
<212> PRT
<213> Homo sapiens

<400> 112
Met Ala Ala Ala Gly Trp Arg Asp Gly Ser Gly Gln Glu Lys Tyr Arg 
1               5                   10                  15      


Leu Val Val Val Gly Gly Gly Gly Val Gly Lys Ser Ala Leu Thr Ile 
            20                  25                  30          


Gln Phe Ile Gln Ser Tyr Phe Val Thr Asp Tyr Asp Pro Thr Ile Glu 
        35                  40                  45              


Asp Ser Tyr Thr Lys Gln Cys Val Ile Asp Asp Arg Ala Ala Arg Leu 
    50                  55                  60                  


Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Phe Gly Ala Met Arg Glu 
65                  70                  75                  80  


Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Leu Val Phe Ser Val Thr 
                85                  90                  95      


Asp Arg Gly Ser Phe Glu Glu Ile Tyr Lys Phe Gln Arg Gln Ile Leu 
            100                 105                 110         


Arg Val Lys Asp Arg Asp Glu Phe Pro Met Ile Leu Ile Gly Asn Lys 
        115                 120                 125             


Ala Asp Leu Asp His Gln Arg Gln Val Thr Gln Glu Glu Gly Gln Gln 
    130                 135                 140                 


Leu Ala Arg Gln Leu Lys Val Thr Tyr Met Glu Ala Ser Ala Lys Ile 
145                 150                 155                 160 


Arg Met Asn Val Asp Gln Ala Phe His Glu Leu Val Arg Val Ile Arg 
                165                 170                 175     


Lys Phe Gln Glu Gln Glu Cys Pro Pro Ser Pro Glu Pro Thr Arg Lys 
            180                 185                 190         


Glu Lys Asp Lys Lys Gly Cys His Cys Val Ile Phe 
        195                 200                 


<210> 113
<211> 2209
<212> DNA
<213> Homo sapiens

<400> 113
gggagggcgg agctggaagg gtgggaagca ccgatccacc ttattgctct ggccgaggcc       60

agagacctcc gggagaggct gggccaccga gccgggcttt actgctccga gggtccgggc      120

gtggggctgg agctggagcc ccgcgcgctg cttttccagc cgcctgcggc cgcgccttca      180

ccgtcggggc gatagcggtg gcaacttggc cgcggctccg cgtggtctcc gggcttcccc      240

gcgccgcctg agccggagct gcccgcttca atcctatttt gtaacggatt atgatccaac      300

cattgaagat tcttacacaa agcagtgtgt gatagatgac agagcagccc ggctagatat      360

tttggataca gcaggacaag aagagtttgg agccatgaga gaacagtata tgaggactgg      420

cgaaggcttc ctgttggtct tttcagtcac agatagaggc agttttgaag aaatctataa      480

gtttcaaaga cagattctca gagtaaagga tcgtgatgag ttcccaatga ttttaattgg      540

taataaagca gatctggatc atcaaagaca ggtaacacag gaagaaggac aacagttagc      600

acggcagctt aaggtaacat acatggaggc atcagcaaag attaggatga atgtagatca      660

agctttccat gaacttgtcc gggttatcag gaaatttcaa gagcaggaat gtcctccttc      720

accagaacca acacggaaag aaaaagacaa gaaaggctgc cattgtgtca ttttctagaa      780

tcccttcagt tttagctacc aacggccagg aaaagccctc atcttctctt tctctcctca      840

gtttacatct tgttggtacc tttctagcct tagacaaatg atcaccatgt tagccttaga      900

cgaagaagct ggctagtcct ttctgtgaag ctaatacaat ggtcatttcc agacaaattt      960

aaaggaaaca ctaaggctgc ttcaaagatt atctgattcc tttaaaatat atgtctatat     1020

acacagacat gctctttttt taagtgctta cattttaata gagatgaatc agttttggaa     1080

tctaagctgt ttgccaagct gaagctacag gttgtgaaat aatttttaac ttttggaatc     1140

atactgccta ctgttactct aaatagaaat atagggtttt ttttaatgtg aatttttgcc     1200

tatctttaaa catttcaatg tcagcctttg ttaaccttaa atacactgaa ttgaatctac     1260

aaaagtgaac catctcagac ctttactgat actacaactt ttgttttctg atggccaaaa     1320

taccaaatgc ctgttgtatt tatggattaa aaactgctta taaaaccctg tgttactact     1380

cctactcttg gagatgataa tattctatgt ggtcaaatat ttggactcat ttaggactta     1440

gatatttcag tgtacttgat tttttaattt aactcttttt cacagccacg ctaagggtaa     1500

aaaggaataa tttccttctg tcttcctttt caagtatttc tgggtaaggg attcaaaaaa     1560

ctaaaactgt ttttgtttgt aatataaaat atggaattga tctttccagg gtcagagatg     1620

attaatgttt ttgctatata cttttataca ttattttctt atcaaactag ttaacaagta     1680

tttttatatg tttgtaagca gatatgcttt catagcatac cttgtgtata tgtaaagata     1740

agtatttaat tctcactgtt cacttttaac tgacaaagaa aaacaagtgg aaactacaga     1800

aactgtggta gaacttttac ttgctggtct ggtcttggtt gtacccatct ttggccagtc     1860

acataactac tcaagaaacc ttcccaatag agtacaacag gatgagactc tgaaatcact     1920

ttcagtattc cctgctagat attgattgtt atttcaagta ttaagtgtaa gcttttaatg     1980

gataattagt ataactgtgg atggcatctg attttgtttt taattctgtg gattgtgttt     2040

aagcaattca atagtatgtt cctgattttg agatgctaag tggtattgca cagttgtcac     2100

tttatcaagt gtgtacaaca gtcccatgaa gtttatagag catacccttg tatagcttca     2160

ggtgctagaa ttaaaattga tctgttatca caagaaaaaa aaaaaaaaa                 2209


<210> 114
<211> 127
<212> PRT
<213> Homo sapiens

<400> 114
Met Arg Glu Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Leu Val Phe 
1               5                   10                  15      


Ser Val Thr Asp Arg Gly Ser Phe Glu Glu Ile Tyr Lys Phe Gln Arg 
            20                  25                  30          


Gln Ile Leu Arg Val Lys Asp Arg Asp Glu Phe Pro Met Ile Leu Ile 
        35                  40                  45              


Gly Asn Lys Ala Asp Leu Asp His Gln Arg Gln Val Thr Gln Glu Glu 
    50                  55                  60                  


Gly Gln Gln Leu Ala Arg Gln Leu Lys Val Thr Tyr Met Glu Ala Ser 
65                  70                  75                  80  


Ala Lys Ile Arg Met Asn Val Asp Gln Ala Phe His Glu Leu Val Arg 
                85                  90                  95      


Val Ile Arg Lys Phe Gln Glu Gln Glu Cys Pro Pro Ser Pro Glu Pro 
            100                 105                 110         


Thr Arg Lys Glu Lys Asp Lys Lys Gly Cys His Cys Val Ile Phe 
        115                 120                 125         


<210> 115
<211> 2054
<212> DNA
<213> Homo sapiens

<400> 115
atctcagatg catgcagctc ctgctgggcg gtttcattct ctgccagcca ttcattcaca       60

ttaaaagcaa tggcccatta aggaaataag tggatgatgc tcctccatca cccatgtcct      120

attttgtaac ggattatgat ccaaccattg aagattctta cacaaagcag tgtgtgatag      180

atgacagagc agcccggcta gatattttgg atacagcagg acaagaagag tttggagcca      240

tgagagaaca gtatatgagg actggcgaag gcttcctgtt ggtcttttca gtcacagata      300

gaggcagttt tgaagaaatc tataagtttc aaagacagat tctcagagta aaggatcgtg      360

atgagttccc aatgatttta attggtaata aagcagatct ggatcatcaa agacaggtaa      420

cacaggaaga aggacaacag ttagcacggc agcttaaggt aacatacatg gaggcatcag      480

caaagattag gatgaatgta gatcaagctt tccatgaact tgtccgggtt atcaggaaat      540

ttcaagagca ggaatgtcct ccttcaccag aaccaacacg gaaagaaaaa gacaagaaag      600

gctgccattg tgtcattttc tagaatccct tcagttttag ctaccaacgg ccaggaaaag      660

ccctcatctt ctctttctct cctcagttta catcttgttg gtacctttct agccttagac      720

aaatgatcac catgttagcc ttagacgaag aagctggcta gtcctttctg tgaagctaat      780

acaatggtca tttccagaca aatttaaagg aaacactaag gctgcttcaa agattatctg      840

attcctttaa aatatatgtc tatatacaca gacatgctct ttttttaagt gcttacattt      900

taatagagat gaatcagttt tggaatctaa gctgtttgcc aagctgaagc tacaggttgt      960

gaaataattt ttaacttttg gaatcatact gcctactgtt actctaaata gaaatatagg     1020

gtttttttta atgtgaattt ttgcctatct ttaaacattt caatgtcagc ctttgttaac     1080

cttaaataca ctgaattgaa tctacaaaag tgaaccatct cagaccttta ctgatactac     1140

aacttttgtt ttctgatggc caaaatacca aatgcctgtt gtatttatgg attaaaaact     1200

gcttataaaa ccctgtgtta ctactcctac tcttggagat gataatattc tatgtggtca     1260

aatatttgga ctcatttagg acttagatat ttcagtgtac ttgatttttt aatttaactc     1320

tttttcacag ccacgctaag ggtaaaaagg aataatttcc ttctgtcttc cttttcaagt     1380

atttctgggt aagggattca aaaaactaaa actgtttttg tttgtaatat aaaatatgga     1440

attgatcttt ccagggtcag agatgattaa tgtttttgct atatactttt atacattatt     1500

ttcttatcaa actagttaac aagtattttt atatgtttgt aagcagatat gctttcatag     1560

cataccttgt gtatatgtaa agataagtat ttaattctca ctgttcactt ttaactgaca     1620

aagaaaaaca agtggaaact acagaaactg tggtagaact tttacttgct ggtctggtct     1680

tggttgtacc catctttggc cagtcacata actactcaag aaaccttccc aatagagtac     1740

aacaggatga gactctgaaa tcactttcag tattccctgc tagatattga ttgttatttc     1800

aagtattaag tgtaagcttt taatggataa ttagtataac tgtggatggc atctgatttt     1860

gtttttaatt ctgtggattg tgtttaagca attcaatagt atgttcctga ttttgagatg     1920

ctaagtggta ttgcacagtt gtcactttat caagtgtgta caacagtccc atgaagttta     1980

tagagcatac ccttgtatag cttcaggtgc tagaattaaa attgatctgt tatcacaaga     2040

aaaaaaaaaa aaaa                                                       2054


<210> 116
<211> 169
<212> PRT
<213> Homo sapiens

<400> 116
Met Ser Tyr Phe Val Thr Asp Tyr Asp Pro Thr Ile Glu Asp Ser Tyr 
1               5                   10                  15      


Thr Lys Gln Cys Val Ile Asp Asp Arg Ala Ala Arg Leu Asp Ile Leu 
            20                  25                  30          


Asp Thr Ala Gly Gln Glu Glu Phe Gly Ala Met Arg Glu Gln Tyr Met 
        35                  40                  45              


Arg Thr Gly Glu Gly Phe Leu Leu Val Phe Ser Val Thr Asp Arg Gly 
    50                  55                  60                  


Ser Phe Glu Glu Ile Tyr Lys Phe Gln Arg Gln Ile Leu Arg Val Lys 
65                  70                  75                  80  


Asp Arg Asp Glu Phe Pro Met Ile Leu Ile Gly Asn Lys Ala Asp Leu 
                85                  90                  95      


Asp His Gln Arg Gln Val Thr Gln Glu Glu Gly Gln Gln Leu Ala Arg 
            100                 105                 110         


Gln Leu Lys Val Thr Tyr Met Glu Ala Ser Ala Lys Ile Arg Met Asn 
        115                 120                 125             


Val Asp Gln Ala Phe His Glu Leu Val Arg Val Ile Arg Lys Phe Gln 
    130                 135                 140                 


Glu Gln Glu Cys Pro Pro Ser Pro Glu Pro Thr Arg Lys Glu Lys Asp 
145                 150                 155                 160 


Lys Lys Gly Cys His Cys Val Ile Phe 
                165                 


<210> 117
<211> 2186
<212> DNA
<213> Homo sapiens

<400> 117
attgctctgg ccgaggccag agacctccgg gagaggctgg gccaccgagc cgggctttac       60

tgctccgagg gtccgggcgt ggggctggag ctggagcccc gcgcgctgct tttccagccg      120

cctgcggccg cgccttcacc gtcggggcga tagcggtggc aacttggccg cggctccgcg      180

tggtctccgg gcttccccgc gccgcctgag ccggagctgc ccgcttcaag tactgtgtat      240

ttctttgttc ctattttgta acggattatg atccaaccat tgaagattct tacacaaagc      300

agtgtgtgat agatgacaga gcagcccggc tagatatttt ggatacagca ggacaagaag      360

agtttggagc catgagagaa cagtatatga ggactggcga aggcttcctg ttggtctttt      420

cagtcacaga tagaggcagt tttgaagaaa tctataagtt tcaaagacag attctcagag      480

taaaggatcg tgatgagttc ccaatgattt taattggtaa taaagcagat ctggatcatc      540

aaagacaggt aacacaggaa gaaggacaac agttagcacg gcagcttaag gtaacataca      600

tggaggcatc agcaaagatt aggatgaatg tagatcaagc tttccatgaa cttgtccggg      660

ttatcaggaa atttcaagag caggaatgtc ctccttcacc agaaccaaca cggaaagaaa      720

aagacaagaa aggctgccat tgtgtcattt tctagaatcc cttcagtttt agctaccaac      780

ggccaggaaa agccctcatc ttctctttct ctcctcagtt tacatcttgt tggtaccttt      840

ctagccttag acaaatgatc accatgttag ccttagacga agaagctggc tagtcctttc      900

tgtgaagcta atacaatggt catttccaga caaatttaaa ggaaacacta aggctgcttc      960

aaagattatc tgattccttt aaaatatatg tctatataca cagacatgct ctttttttaa     1020

gtgcttacat tttaatagag atgaatcagt tttggaatct aagctgtttg ccaagctgaa     1080

gctacaggtt gtgaaataat ttttaacttt tggaatcata ctgcctactg ttactctaaa     1140

tagaaatata gggttttttt taatgtgaat ttttgcctat ctttaaacat ttcaatgtca     1200

gcctttgtta accttaaata cactgaattg aatctacaaa agtgaaccat ctcagacctt     1260

tactgatact acaacttttg ttttctgatg gccaaaatac caaatgcctg ttgtatttat     1320

ggattaaaaa ctgcttataa aaccctgtgt tactactcct actcttggag atgataatat     1380

tctatgtggt caaatatttg gactcattta ggacttagat atttcagtgt acttgatttt     1440

ttaatttaac tctttttcac agccacgcta agggtaaaaa ggaataattt ccttctgtct     1500

tccttttcaa gtatttctgg gtaagggatt caaaaaacta aaactgtttt tgtttgtaat     1560

ataaaatatg gaattgatct ttccagggtc agagatgatt aatgtttttg ctatatactt     1620

ttatacatta ttttcttatc aaactagtta acaagtattt ttatatgttt gtaagcagat     1680

atgctttcat agcatacctt gtgtatatgt aaagataagt atttaattct cactgttcac     1740

ttttaactga caaagaaaaa caagtggaaa ctacagaaac tgtggtagaa cttttacttg     1800

ctggtctggt cttggttgta cccatctttg gccagtcaca taactactca agaaaccttc     1860

ccaatagagt acaacaggat gagactctga aatcactttc agtattccct gctagatatt     1920

gattgttatt tcaagtatta agtgtaagct tttaatggat aattagtata actgtggatg     1980

gcatctgatt ttgtttttaa ttctgtggat tgtgtttaag caattcaata gtatgttcct     2040

gattttgaga tgctaagtgg tattgcacag ttgtcacttt atcaagtgtg tacaacagtc     2100

ccatgaagtt tatagagcat acccttgtat agcttcaggt gctagaatta aaattgatct     2160

gttatcacaa gaaaaaaaaa aaaaaa                                          2186


<210> 118
<211> 127
<212> PRT
<213> Homo sapiens

<400> 118
Met Arg Glu Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Leu Val Phe 
1               5                   10                  15      


Ser Val Thr Asp Arg Gly Ser Phe Glu Glu Ile Tyr Lys Phe Gln Arg 
            20                  25                  30          


Gln Ile Leu Arg Val Lys Asp Arg Asp Glu Phe Pro Met Ile Leu Ile 
        35                  40                  45              


Gly Asn Lys Ala Asp Leu Asp His Gln Arg Gln Val Thr Gln Glu Glu 
    50                  55                  60                  


Gly Gln Gln Leu Ala Arg Gln Leu Lys Val Thr Tyr Met Glu Ala Ser 
65                  70                  75                  80  


Ala Lys Ile Arg Met Asn Val Asp Gln Ala Phe His Glu Leu Val Arg 
                85                  90                  95      


Val Ile Arg Lys Phe Gln Glu Gln Glu Cys Pro Pro Ser Pro Glu Pro 
            100                 105                 110         


Thr Arg Lys Glu Lys Asp Lys Lys Gly Cys His Cys Val Ile Phe 
        115                 120                 125         


<210> 119
<211> 5820
<212> DNA
<213> Homo sapiens

<400> 119
agccgctgcg cccgagctgg cctgcgagtt cagggctcct gtcgctctcc aggagcaacc       60

tctactccgg acgcacaggc attccccgcg cccctccagc cctcgccgcc ctcgccaccg      120

ctcccggccg ccgcgctccg gtacacacag gatccctgct gggcaccaac agctccacca      180

tggggctggc ctggggacta ggcgtcctgt tcctgatgca tgtgtgtggc accaaccgca      240

ttccagagtc tggcggagac aacagcgtgt ttgacatctt tgaactcacc ggggccgccc      300

gcaaggggtc tgggcgccga ctggtgaagg gccccgaccc ttccagccca gctttccgca      360

tcgaggatgc caacctgatc ccccctgtgc ctgatgacaa gttccaagac ctggtggatg      420

ctgtgcgggc agaaaagggt ttcctccttc tggcatccct gaggcagatg aagaagaccc      480

ggggcacgct gctggccctg gagcggaaag accactctgg ccaggtcttc agcgtggtgt      540

ccaatggcaa ggcgggcacc ctggacctca gcctgaccgt ccaaggaaag cagcacgtgg      600

tgtctgtgga agaagctctc ctggcaaccg gccagtggaa gagcatcacc ctgtttgtgc      660

aggaagacag ggcccagctg tacatcgact gtgaaaagat ggagaatgct gagttggacg      720

tccccatcca aagcgtcttc accagagacc tggccagcat cgccagactc cgcatcgcaa      780

aggggggcgt caatgacaat ttccaggggg tgctgcagaa tgtgaggttt gtctttggaa      840

ccacaccaga agacatcctc aggaacaaag gctgctccag ctctaccagt gtcctcctca      900

cccttgacaa caacgtggtg aatggttcca gccctgccat ccgcactaac tacattggcc      960

acaagacaaa ggacttgcaa gccatctgcg gcatctcctg tgatgagctg tccagcatgg     1020

tcctggaact caggggcctg cgcaccattg tgaccacgct gcaggacagc atccgcaaag     1080

tgactgaaga gaacaaagag ttggccaatg agctgaggcg gcctccccta tgctatcaca     1140

acggagttca gtacagaaat aacgaggaat ggactgttga tagctgcact gagtgtcact     1200

gtcagaactc agttaccatc tgcaaaaagg tgtcctgccc catcatgccc tgctccaatg     1260

ccacagttcc tgatggagaa tgctgtcctc gctgttggcc cagcgactct gcggacgatg     1320

gctggtctcc atggtccgag tggacctcct gttctacgag ctgtggcaat ggaattcagc     1380

agcgcggccg ctcctgcgat agcctcaaca accgatgtga gggctcctcg gtccagacac     1440

ggacctgcca cattcaggag tgtgacaaga gatttaaaca ggatggtggc tggagccact     1500

ggtccccgtg gtcatcttgt tctgtgacat gtggtgatgg tgtgatcaca aggatccggc     1560

tctgcaactc tcccagcccc cagatgaacg ggaaaccctg tgaaggcgaa gcgcgggaga     1620

ccaaagcctg caagaaagac gcctgcccca tcaatggagg ctggggtcct tggtcaccat     1680

gggacatctg ttctgtcacc tgtggaggag gggtacagaa acgtagtcgt ctctgcaaca     1740

accccacacc ccagtttgga ggcaaggact gcgttggtga tgtaacagaa aaccagatct     1800

gcaacaagca ggactgtcca attgatggat gcctgtccaa tccctgcttt gccggcgtga     1860

agtgtactag ctaccctgat ggcagctgga aatgtggtgc ttgtccccct ggttacagtg     1920

gaaatggcat ccagtgcaca gatgttgatg agtgcaaaga agtgcctgat gcctgcttca     1980

accacaatgg agagcaccgg tgtgagaaca cggaccccgg ctacaactgc ctgccctgcc     2040

ccccacgctt caccggctca cagcccttcg gccagggtgt cgaacatgcc acggccaaca     2100

aacaggtgtg caagccccgt aacccctgca cggatgggac ccacgactgc aacaagaacg     2160

ccaagtgcaa ctacctgggc cactatagcg accccatgta ccgctgcgag tgcaagcctg     2220

gctacgctgg caatggcatc atctgcgggg aggacacaga cctggatggc tggcccaatg     2280

agaacctggt gtgcgtggcc aatgcgactt accactgcaa aaaggataat tgccccaacc     2340

ttcccaactc agggcaggaa gactatgaca aggatggaat tggtgatgcc tgtgatgatg     2400

acgatgacaa tgataaaatt ccagatgaca gggacaactg tccattccat tacaacccag     2460

ctcagtatga ctatgacaga gatgatgtgg gagaccgctg tgacaactgt ccctacaacc     2520

acaacccaga tcaggcagac acagacaaca atggggaagg agacgcctgt gctgcagaca     2580

ttgatggaga cggtatcctc aatgaacggg acaactgcca gtacgtctac aatgtggacc     2640

agagagacac tgatatggat ggggttggag atcagtgtga caattgcccc ttggaacaca     2700

atccggatca gctggactct gactcagacc gcattggaga tacctgtgac aacaatcagg     2760

atattgatga agatggccac cagaacaatc tggacaactg tccctatgtg cccaatgcca     2820

accaggctga ccatgacaaa gatggcaagg gagatgcctg tgaccacgat gatgacaacg     2880

atggcattcc tgatgacaag gacaactgca gactcgtgcc caatcccgac cagaaggact     2940

ctgacggcga tggtcgaggt gatgcctgca aagatgattt tgaccatgac agtgtgccag     3000

acatcgatga catctgtcct gagaatgttg acatcagtga gaccgatttc cgccgattcc     3060

agatgattcc tctggacccc aaagggacat cccaaaatga ccctaactgg gttgtacgcc     3120

atcagggtaa agaactcgtc cagactgtca actgtgatcc tggactcgct gtaggttatg     3180

atgagtttaa tgctgtggac ttcagtggca ccttcttcat caacaccgaa agggacgatg     3240

actatgctgg atttgtcttt ggctaccagt ccagcagccg cttttatgtt gtgatgtgga     3300

agcaagtcac ccagtcctac tgggacacca accccacgag ggctcaggga tactcgggcc     3360

tttctgtgaa agttgtaaac tccaccacag ggcctggcga gcacctgcgg aacgccctgt     3420

ggcacacagg aaacacccct ggccaggtgc gcaccctgtg gcatgaccct cgtcacatag     3480

gctggaaaga tttcaccgcc tacagatggc gtctcagcca caggccaaag acgggtttca     3540

ttagagtggt gatgtatgaa gggaagaaaa tcatggctga ctcaggaccc atctatgata     3600

aaacctatgc tggtggtaga ctagggttgt ttgtcttctc tcaagaaatg gtgttcttct     3660

ctgacctgaa atacgaatgt agagatccct aatcatcaaa ttgttgattg aaagactgat     3720

cataaaccaa tgctggtatt gcaccttctg gaactatggg cttgagaaaa cccccaggat     3780

cacttctcct tggcttcctt cttttctgtg cttgcatcag tgtggactcc tagaacgtgc     3840

gacctgcctc aagaaaatgc agttttcaaa aacagactca gcattcagcc tccaatgaat     3900

aagacatctt ccaagcatat aaacaattgc tttggtttcc ttttgaaaaa gcatctactt     3960

gcttcagttg ggaaggtgcc cattccactc tgcctttgtc acagagcagg gtgctattgt     4020

gaggccatct ctgagcagtg gactcaaaag cattttcagg catgtcagag aagggaggac     4080

tcactagaat tagcaaacaa aaccaccctg acatcctcct tcaggaacac ggggagcaga     4140

ggccaaagca ctaaggggag ggcgcatacc cgagacgatt gtatgaagaa aatatggagg     4200

aactgttaca tgttcggtac taagtcattt tcaggggatt gaaagactat tgctggattt     4260

catgatgctg actggcgtta gctgattaac ccatgtaaat aggcacttaa atagaagcag     4320

gaaagggaga caaagactgg cttctggact tcctccctga tccccaccct tactcatcac     4380

ctgcagtggc cagaattagg gaatcagaat caaaccagtg taaggcagtg ctggctgcca     4440

ttgcctggtc acattgaaat tggtggcttc attctagatg tagcttgtgc agatgtagca     4500

ggaaaatagg aaaacctacc atctcagtga gcaccagctg cctcccaaag gaggggcagc     4560

cgtgcttata tttttatggt tacaatggca caaaattatt atcaacctaa ctaaaacatt     4620

ccttttctct tttttcctga attatcatgg agttttctaa ttctctcttt tggaatgtag     4680

atttttttta aatgctttac gatgtaaaat atttattttt tacttattct ggaagatctg     4740

gctgaaggat tattcatgga acaggaagaa gcgtaaagac tatccatgtc atctttgttg     4800

agagtcttcg tgactgtaag attgtaaata cagattattt attaactctg ttctgcctgg     4860

aaatttaggc ttcatacgga aagtgtttga gagcaagtag ttgacattta tcagcaaatc     4920

tcttgcaaga acagcacaag gaaaatcagt ctaataagct gctctgcccc ttgtgctcag     4980

agtggatgtt atgggattct ttttttctct gttttatctt ttcaagtgga attagttggt     5040

tatccatttg caaatgtttt aaattgcaaa gaaagccatg aggtcttcaa tactgtttta     5100

ccccatccct tgtgcatatt tccagggaga aggaaagcat atacactttt ttctttcatt     5160

tttccaaaag agaaaaaaat gacaaaaggt gaaacttaca tacaaatatt acctcatttg     5220

ttgtgtgact gagtaaagaa tttttggatc aagcggaaag agtttaagtg tctaacaaac     5280

ttaaagctac tgtagtacct aaaaagtcag tgttgtacat agcataaaaa ctctgcagag     5340

aagtattccc aataaggaaa tagcattgaa atgttaaata caatttctga aagttatgtt     5400

ttttttctat catctggtat accattgctt tatttttata aattattttc tcattgccat     5460

tggaatagat atctcagatt gtgtagatat gctatttaaa taatttatca ggaaatactg     5520

cctgtagagt tagtatttct atttttatat aatgtttgca cactgaattg aagaattgtt     5580

ggttttttct tttttttgtt ttgttttttt tttttttttt ttttgctttt gacctcccat     5640

ttttactatt tgccaatacc tttttctagg aatgtgcttt tttttgtaca catttttatc     5700

cattttacat tctaaagcag tgtaagttgt atattactgt ttcttatgta caaggaacaa     5760

caataaatca tatggaaatt tatatttata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     5820


<210> 120
<211> 1170
<212> PRT
<213> Homo sapiens

<400> 120
Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210> 121
<211> 2974
<212> DNA
<213> Homo sapiens

<400> 121
agaagccccg cagccgccgc gcggagaaca gcgacagccg agcgcccggt ccgcctgtct       60

gccggtgggt ctgcctgccc gcgcagcaga cccggggcgg ccgcgggagc ccgcgccccg      120

cccgccgcgc ctctgccggg acccacccgc agcggagggc tgagcccgcc ggcggctccc      180

cggagctcac ccacctccgc gcgccggagc gcaggcaaaa ggggaggaaa ggctcctctc      240

tttagtcacc actctcgccc tctccaagaa tttgtttaac aaagcgctga ggaaagagaa      300

cgtcttcttg aattctttag taggggcgga gtctgctgct gccctgcgct gccacctcgg      360

ctacactgcc ctccgcgacg acccctgacc agccggggtc acgtccggga gacgggatca      420

tgaagcgctc ggtagccgtc tggctcttgg tcgggctcag cctcggtgtc ccccagttcg      480

gcaaaggtga tatttgtgat cccaatccat gtgaaaatgg aggtatctgt ttgccaggat      540

tggctgatgg ttccttttcc tgtgagtgtc cagatggctt cacagacccc aactgttcta      600

gtgttgtgga ggttgcatca gatgaagaag aaccaacttc agcaggtccc tgcactccta      660

atccatgcca taatggagga acctgtgaaa taagtgaagc ataccgaggg gatacattca      720

taggctatgt ttgtaaatgt ccccgaggat ttaatgggat tcactgtcag cacaacataa      780

atgaatgcga agttgagcct tgcaaaaatg gtggaatatg tacagatctt gttgctaact      840

attcctgtga gtgcccaggc gaatttatgg gaagaaattg tcaatacaaa tgctcaggcc      900

cactgggaat tgaaggtgga attatatcaa accagcaaat cacagcttcc tctactcacc      960

gagctctttt tggactccaa aaatggtatc cctactatgc acgtcttaat aagaaggggc     1020

ttataaatgc gtggacagct gcagaaaatg acagatggcc gtggattcag ataaatttgc     1080

aaaggaaaat gagagttact ggtgtgatta cccaaggagc caagaggatt ggaagcccag     1140

agtatataaa atcctacaaa attgcctaca gtaatgatgg aaagacttgg gcaatgtaca     1200

aagtgaaagg caccaatgaa gacatggtgt ttcgtggaaa cattgataac aacactccat     1260

atgctaactc tttcacaccc cccataaaag ctcagtatgt aagactctat ccccaagttt     1320

gtcgaagaca ttgcactttg cgaatggaac ttcttggctg tgaactgtcg ggttgttctg     1380

agcctctggg tatgaaatca ggacatatac aagactatca gatcactgcc tccagcatct     1440

tcagaacgct caacatggac atgttcactt gggaaccaag gaaagctcgg ctggacaagc     1500

aaggcaaagt gaatgcctgg acctctggcc acaatgacca gtcacaatgg ttacaggtgg     1560

atcttcttgt tccaaccaaa gtgactggca tcattacaca aggagctaaa gattttggtc     1620

atgtacagtt tgttggctcc tacaaactgg cttacagcaa tgatggagaa cactggactg     1680

tataccagga tgaaaagcaa agaaaagata aggttttcca gggaaatttt gacaatgaca     1740

ctcacagaaa aaatgtcatc gaccctccca tctatgcacg acacataaga atccttcctt     1800

ggtcctggta cgggaggatc acattgcggt cagagctgct gggctgcaca gaggaggaat     1860

gaggggaggc tacatttcac aaccctcttc cctatttccc taaaagtatc tccatggaat     1920

gaactgtgca aaatctgtag gaaactgaat ggtttttttt tttttttcat gaaaaagtgc     1980

tcaaattatg gtaggcaact aacggtgttt ttaagggggt ctaagcctgc cttttcaatg     2040

atttaatttg attttatttt atccgtcaaa tctcttaagt aacaacacat taagtgtgaa     2100

ttacttttct ctcattgttt cctgaattat tcgcattggt agaaatatat tagggaaaga     2160

aagtagcctt ctttttatag caagagtaaa aaagtctcaa agtcatcaaa taagagcaag     2220

agttgataga gcttttacaa tcaatactca cctaattctg ataaaaggaa tactgcaatg     2280

ttagcaataa gtttttttct tctgtaatga ctctacgtta tcctgtttcc ctgtgcctac     2340

caaacactgt caatgtttat tacaaaattt taaagaagaa tatgtaacat gcagtactga     2400

tattataatt ctcattttac tttcattatt tctaataaga gattatgtga cttctttttc     2460

ttttagttct attctacatt cttaatattg tatattacct gaataattca atttttttct     2520

aattgaattt cctattagtt gactaaaaga agtgtcatgt ttactcatat atgtagaaca     2580

tgactgccta tcagtagatt gatctgtatt taatattcgt taattaaatc tgcagtttta     2640

tttttgaagg aagccataac tatttaattt ccaaataatt gcttcataaa gaatcccata     2700

ctctcagttt gcacaaaaga acaaaaaata tatatgtctc tttaaattta aatcttcatt     2760

tagatggtaa ttacatatcc ttatatttac tttaaaaaat cggcttattt gtttatttta     2820

taaaaaattt agcaaagaaa tattaatata gtgctgcata gtttggccaa gcatactcat     2880

catttctttg ttcagctcca catttcctgt gaaactaaca tcttattgag atttgaaact     2940

ggtggtagtt tcccaggaag gcacaggtgg agtt                                 2974


<210> 122
<211> 480
<212> PRT
<213> Homo sapiens

<400> 122
Met Lys Arg Ser Val Ala Val Trp Leu Leu Val Gly Leu Ser Leu Gly 
1               5                   10                  15      


Val Pro Gln Phe Gly Lys Gly Asp Ile Cys Asp Pro Asn Pro Cys Glu 
            20                  25                  30          


Asn Gly Gly Ile Cys Leu Pro Gly Leu Ala Asp Gly Ser Phe Ser Cys 
        35                  40                  45              


Glu Cys Pro Asp Gly Phe Thr Asp Pro Asn Cys Ser Ser Val Val Glu 
    50                  55                  60                  


Val Ala Ser Asp Glu Glu Glu Pro Thr Ser Ala Gly Pro Cys Thr Pro 
65                  70                  75                  80  


Asn Pro Cys His Asn Gly Gly Thr Cys Glu Ile Ser Glu Ala Tyr Arg 
                85                  90                  95      


Gly Asp Thr Phe Ile Gly Tyr Val Cys Lys Cys Pro Arg Gly Phe Asn 
            100                 105                 110         


Gly Ile His Cys Gln His Asn Ile Asn Glu Cys Glu Val Glu Pro Cys 
        115                 120                 125             


Lys Asn Gly Gly Ile Cys Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu 
    130                 135                 140                 


Cys Pro Gly Glu Phe Met Gly Arg Asn Cys Gln Tyr Lys Cys Ser Gly 
145                 150                 155                 160 


Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala 
                165                 170                 175     


Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr 
            180                 185                 190         


Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala 
        195                 200                 205             


Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met 
    210                 215                 220                 


Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro 
225                 230                 235                 240 


Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr 
                245                 250                 255     


Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg 
            260                 265                 270         


Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro 
        275                 280                 285             


Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His 
    290                 295                 300                 


Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser 
305                 310                 315                 320 


Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile Thr 
                325                 330                 335     


Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp Glu 
            340                 345                 350         


Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp Thr 
        355                 360                 365             


Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu Val 
    370                 375                 380                 


Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly 
385                 390                 395                 400 


His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly 
                405                 410                 415     


Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys Val 
            420                 425                 430         


Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile Asp 
        435                 440                 445             


Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser Trp Tyr 
    450                 455                 460                 


Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys Thr Glu Glu Glu 
465                 470                 475                 480 


<210> 123
<211> 1606
<212> DNA
<213> Homo sapiens

<400> 123
aaatgtgacc ggccgcggct ccggcagtca acgcctgcct cctctcgagc gtcctcagcg       60

cagccgccgc ccgcggagcc agcacgaacg agcccagcac cggccggatg gagcgtccgc      120

aacccgacag catgccccag gatttgtcag aggccctgaa ggaggccacc aaggaggtgc      180

acacccaggc agagaatgct gagttcatga ggaactttca gaagggccag gtgacccgag      240

acggcttcaa gctggtgatg gcctccctgt accacatcta tgtggccctg gaggaggaga      300

ttgagcgcaa caaggagagc ccagtcttcg cccctgtcta cttcccagaa gagctgcacc      360

gcaaggctgc cctggagcag gacctggcct tctggtacgg gccccgctgg caggaggtca      420

tcccctacac accagccatg cagcgctatg tgaagcggct ccacgaggtg gggcgcacag      480

agcccgagct gctggtggcc cacgcctaca cccgctacct gggtgacctg tctgggggcc      540

aggtgctcaa aaagattgcc cagaaagccc tggacctgcc cagctctggc gagggcctgg      600

ccttcttcac cttccccaac attgccagtg ccaccaagtt caagcagctc taccgctccc      660

gcatgaactc cctggagatg actcccgcag tcaggcagag ggtgatagaa gaggccaaga      720

ctgcgttcct gctcaacatc cagctctttg aggagttgca ggagctgctg acccatgaca      780

ccaaggacca gagcccctca cgggcaccag ggcttcgcca gcgggccagc aacaaagtgc      840

aagattctgc ccccgtggag actcccagag ggaagccccc actcaacacc cgctcccagg      900

ctccgcttct ccgatgggtc cttacactca gctttctggt ggcgacagtt gctgtagggc      960

tttatgccat gtgaatgcag gcatgctggc tcccagggcc atgaactttg tccggtggaa     1020

ggccttcttt ctagagaggg aattctcttg gctggcttcc ttaccgtggg cactgaaggc     1080

tttcagggcc tccagccctc tcactgtgtc cctctctctg gaaaggagga aggagcctat     1140

ggcatcttcc ccaacgaaaa gcacatccag gcaatggcct aaacttcaga gggggcgaag     1200

ggatcagccc tgcccttcag catcctcagt tcctgcagca gagcctggaa gacaccctaa     1260

tgtggcagct gtctcaaacc tccaaaagcc ctgagtttca agtatccttg ttgacacggc     1320

catgaccact ttccccgtgg gccatggcaa tttttacaca aacctgaaaa gatgttgtgt     1380

cttgtgtttt tgtcttattt ttgttggagc cactctgttc ctggctcagc ctcaaatgca     1440

gtatttttgt tgtgttctgt tgtttttata gcagggttgg ggtggttttt gagccatgcg     1500

tgggtgggga gggaggtgtt taacggcact gtggccttgg tctaactttt gtgtgaaata     1560

ataaacaaca ttgtctgata gtagcttgaa aaaaaaaaaa aaaaaa                    1606


<210> 124
<211> 288
<212> PRT
<213> Homo sapiens

<400> 124
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Arg Ser Gln Ala Pro Leu Leu Arg Trp Val Leu 
            260                 265                 270         


Thr Leu Ser Phe Leu Val Ala Thr Val Ala Val Gly Leu Tyr Ala Met 
        275                 280                 285             


<210> 125
<211> 2585
<212> DNA
<213> Homo sapiens

<400> 125
gcggaagtta tttttccccc ggccggcagg gagttgtagt tatctttgaa agccttctct       60

ctcttttggc ataggcggga aatgtggcgt caagaggctg ggattccgag aaagaagcga      120

ggctttcacg aaaatgcgag cggcttcggc aaggggcggg gccgctggac gtggatgaaa      180

gctacagagc cagcgtggac caatcagacc tctttggggc ggggcctctg tggataagtg      240

ggcgtggtct aggggggaag tcaccaagaa cgcaccggag gtccttgccc gccctggaaa      300

acgccctctg cggtgaagga gagaccacac tgccatgcct ccctctgggc cccgaggaac      360

cctccttctg ttgccgctgc tgctgctgct cctgcttcgc gccgtgctgg ctgtccccct      420

ggagcgaggg gcgcccaaca aggaggagac ccctgcgact gagagtcccg acacaggcct      480

gtactaccac cggtacctcc aggaggtcat cgatgtactg gagacggatg ggcatttccg      540

agagaagctg caggctgcca atgcggagga catcaagagc gggaagctga gccgagagct      600

ggactttgtc agccaccacg tccgcaccaa gctggatgag ctcaagcgac aggaggtgtc      660

acggctgcgg atgctgctca aggccaagat ggacgccgag caggatccca atgtacaggt      720

ggatcatctg aatctcctga aacagtttga acacctggac cctcagaacc agcatacatt      780

cgaggcccgc gacctggagc tgctgatcca gacggccacc cgggaccttg cccagtacga      840

cgcagcccat catgaagagt tcaagcgcta cgagatgctt aaggaacacg agagacggcg      900

ttatctggag tcactgggag aggagcagag aaaggaggcg gagaggaagc tggaagagca      960

acagcgccgg caccgcgagc accctaaagt caacgtgcct ggcagccaag cccagttgaa     1020

ggaggtgtgg gaggagctgg atggactgga ccccaacagg tttaacccca agaccttctt     1080

catactgcat gatatcaaca gtgatggtgt cctggatgag caggagctgg aggcactctt     1140

caccaaggag ctggagaaag tgtacgaccc aaagaatgag gaggacgaca tgcgggagat     1200

ggaggaggag cgactgcgca tgcgggagca tgtgatgaag aatgtggaca ccaaccagga     1260

ccgcctcgtg accctggagg agttcctcgc atccactcag aggaaggagt ttggggacac     1320

cggggagggc tgggagacag tggagatgca ccctgcctac accgaggaag agctgaggcg     1380

ctttgaagag gagctggctg cccgggaggc agagctgaat gccaaggccc agcgcctcag     1440

ccaggagaca gaggctctag ggcggtccca gggccgcctg gaggcccaga agagagagct     1500

gcagcaggct gtgctgcaca tggagcagcg gaagcagcag cagcagcagc agcaaggcca     1560

caaggccccg gctgcccacc ctgaggggca gctcaagttc cacccagaca cagacgatgt     1620

acctgtccca gctccagccg gtgaccagaa ggaggtggac acttcagaaa agaaacttct     1680

cgagcggctc cctgaggttg aggtgcccca gcatctgtga tcctccggga ccccagccct     1740

caggattcct gatgctccaa ggcgactgat gggcgctgga tgaagtggca cagtcagctt     1800

ccctgggggc tggtgtcatg ttgggctcct ggggcggggg cacggcctgg catttcacgc     1860

attgctgcca ccccaggtcc acctgtctcc actttcacag cctccaagtc tgtggctctt     1920

cccttctgtc ctccgagggg cttgccttct ctcgtgtcca gtgaggtgct cagtgatcgg     1980

cttaacttag agaagcccgc cccctcccct tctccgtctg tcccaagagg gtctgctctg     2040

agcctgcgtt cctaggtggc tcggcctcag ctgcctgggt tgtggccgcc ctagcatcct     2100

gtatgcccac agctactgga atccccgctg ctgctccggg ccaagcttct ggttgattaa     2160

tgagggcatg gggtggtccc tcaagacctt cccctacctt ttgtggaacc agtgatgcct     2220

caaagacagt gtcccctcca cagctgggtg ccaggggcag gggatcctca gtatagccgg     2280

tgaaccctga taccaggagc ctgggcctcc ctgaacccct ggcttccagc catctcatcg     2340

ccagcctcct cctggacctc ttggccccca gccccttccc cacacagccc cagaagggtc     2400

ccagagctga ccccactcca ggacctaggc ccagcccctc agcctcatct ggagcccctg     2460

aagaccagtc ccacccacct ttctggcctc atctgacact gctccgcatc ctgctgtgtg     2520

tcctgttcca tgttccggtt ccatccaaat acactttctg gaacaaatgc atggctccaa     2580

aaaaa                                                                 2585


<210> 126
<211> 461
<212> PRT
<213> Homo sapiens

<400> 126
Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 
        115                 120                 125             


Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 
    130                 135                 140                 


Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 
145                 150                 155                 160 


Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 
                165                 170                 175     


Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 
            180                 185                 190         


Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 
        195                 200                 205             


Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 
    210                 215                 220                 


Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 
225                 230                 235                 240 


Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser 
                245                 250                 255     


Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu 
            260                 265                 270         


Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu 
        275                 280                 285             


Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val 
    290                 295                 300                 


Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser 
305                 310                 315                 320 


Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val 
                325                 330                 335     


Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu 
            340                 345                 350         


Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu 
        355                 360                 365             


Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala 
    370                 375                 380                 


Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro 
                405                 410                 415     


Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro 
            420                 425                 430         


Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu 
        435                 440                 445             


Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu 
    450                 455                 460     


<210> 127
<211> 1067
<212> DNA
<213> Homo sapiens

<400> 127
ggcggacgct ccacgtgtcc ctcgccgcgc cccgtctacc cgcccctgcc ctgaggaccc       60

tagtccaaca tggcggcgcc cagcggaggg tggaacggcg tcggcgcgag cttgtgggcc      120

gcgctgctcc taggggccgt ggcgctgagg ccggcggagg cggtgtccga gcccacgacg      180

gtggcgtttg acgtgcggcc cggcggcgtc gtgcattcct tctcccataa cgtgggcccg      240

ggggacaaat atacgtgtat gttcacttac gcctctcaag gagggaccaa tgagcaatgg      300

cagatgagtc tggggaccag cgaagaccac cagcacttca cctgcaccat ctggaggccc      360

caggggaagt cctatctgta cttcacacag ttcaaggcag aggtgcgggg cgctgagatt      420

gagtacgcca tggcctactc taaagccgca tttgaaaggg aaagtgatgt ccctctgaaa      480

actgaggaat ttgaagtgac caaaacagca gtggctcaca ggcccggggc attcaaagct      540

gagctgtcca agctggtgat tgtggccaag gcatcgcgca ctgagctgtg accagcagcc      600

ctgttgcggg tggcaccttc tcatctccgg tgaagctgaa ggggcctgtg tccctgaaag      660

ggccagcaca tcactggttt tctaggaggg actcttaagt tttctacctg ggctgacgtt      720

gccttgtccg gaggggcttg cagggtggct gaagccctgg ggcagagaac agagggtcca      780

gggccctcct ggctcccaac agcttctcag ttcccacttc ctgctgagct cttctggact      840

caggatcgca gatccggggc acaaagaggg tggggaacat gggggctatg ctggggaaag      900

cagccatgct ccccccgacc tccagccgag catccttcat gagcctgcag aactgctttc      960

ctatgtttac ccaggggacc tcctttcaga tgaactggga agagatgaaa tgttttttca     1020

tatttaaata aataagaaca ttaaaaagca aaaaaaaaaa aaaaaaa                   1067


<210> 128
<211> 173
<212> PRT
<213> Homo sapiens

<400> 128
Met Ala Ala Pro Ser Gly Gly Trp Asn Gly Val Gly Ala Ser Leu Trp 
1               5                   10                  15      


Ala Ala Leu Leu Leu Gly Ala Val Ala Leu Arg Pro Ala Glu Ala Val 
            20                  25                  30          


Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val Val 
        35                  40                  45              


His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys Met 
    50                  55                  60                  


Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met Ser 
65                  70                  75                  80  


Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp Arg 
                85                  90                  95      


Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu Val 
            100                 105                 110         


Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala Phe 
        115                 120                 125             


Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val Thr 
    130                 135                 140                 


Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu Leu Ser 
145                 150                 155                 160 


Lys Leu Val Ile Val Ala Lys Ala Ser Arg Thr Glu Leu 
                165                 170             


<210> 129
<211> 2029
<212> DNA
<213> Homo sapiens

<400> 129
ccgagggtga cactcgggct tgggacaggg cgtgctgccg cgggtcacgt gctgcggagg       60

cttggggagg ggcggcgagg cggggtttat agcccgggcg cccgcgggcc ccacgctttg      120

accgggtcgt ggcagccgga gtcgtcttcg ggacgcgcct gctcttcgcc tttcgctgca      180

gtccgtcgat ttctttctcc aggaagaaaa atggcatccg ttgcagttga tccacaaccg      240

agtgtggtga ctcgggtggt caacctgccc ttggtgagct ccacgtatga cctcatgtcc      300

tcagcctatc tcagtacaaa ggaccagtat ccctacctga agtctgtgtg tgagatggca      360

gagaacggtg tgaagaccat cacctccgtg gccatgacca gtgctctgcc catcatccag      420

aagctagagc cgcaaattgc agttgccaat acctatgcct gtaaggggct agacaggatt      480

gaggagagac tgcctattct gaatcagcca tcaactcaga ttgttgccaa tgccaaaggc      540

gctgtgactg gggcaaaaga tgctgtgacg actactgtga ctggggccaa ggattctgtg      600

gccagcacga tcacaggggt gatggacaag accaaagggg cagtgactgg cagtgtggag      660

aagaccaagt ctgtggtcag tggcagcatt aacacagtct tggggagtcg gatgatgcag      720

ctcgtgagca gtggcgtaga aaatgcactc accaaatcag agctgttggt agaacagtac      780

ctccctctca ctgaggaaga actagaaaaa gaagcaaaaa aagttgaagg atttgatctg      840

gttcagaagc caagttatta tgttagactg ggatccctgt ctaccaagct tcactcccgt      900

gcctaccagc aggctctcag cagggttaaa gaagctaagc aaaaaagcca acagaccatt      960

tctcagctcc attctactgt tcacctgatt gaatttgcca ggaagaatgt gtatagtgcc     1020

aatcagaaaa ttcaggatgc tcaggataag ctctacctct catgggtaga gtggaaaagg     1080

agcattggat atgatgatac tgatgagtcc cactgtgctg agcacattga gtcacgtact     1140

cttgcaattg cccgcaacct gactcagcag ctccagacca cgtgccacac cctcctgtcc     1200

aacatccaag gtgtaccaca gaacatccaa gatcaagcca agcacatggg ggtgatggca     1260

ggcgacatct actcagtgtt ccgcaatgct gcctccttta aagaagtgtc tgacagcctc     1320

ctcacttcta gcaaggggca gctgcagaaa atgaaggaat ctttagatga cgtgatggat     1380

tatcttgtta acaacacgcc cctcaactgg ctggtaggtc ccttttatcc tcagctgact     1440

gagtctcaga atgctcagga ccaaggtgca gagatggaca agagcagcca ggagacccag     1500

cgatctgagc ataaaactca ttaaacctgc ccctatcact agtgcatgct gtggccagac     1560

agatgacacc ttttgttatg ttgaaattaa cttgctaggc aaccctaaat tgggaagcaa     1620

gtagctagta taaaggccct caattgtagt tgtttccagc tgaattaaga gctttaaagt     1680

ttctggcatt agcagatgat ttctgttcac ctggtaagaa aagaatgata ggcttgtcag     1740

agcctatagc cagaactcag aaaaaattca aatgcactta tgttctcatt ctatggccat     1800

tgtgttgcct ctgttactgt ttgtattgaa taaaaacatc ttcatgtggg ctggggtaga     1860

aactggtgtc tgctctggtg tgatctgaaa aggcgtcttc actgctttat ctcatgatgc     1920

ttgcttgtaa aacttgattt tagtttttca tttctcaaat aggaatacta cctttgaatt     1980

caataaaatt cactgcagga tagaccagtt aaaaaaaaaa aaaaaaaaa                 2029


<210> 130
<211> 437
<212> PRT
<213> Homo sapiens

<400> 130
Met Ala Ser Val Ala Val Asp Pro Gln Pro Ser Val Val Thr Arg Val 
1               5                   10                  15      


Val Asn Leu Pro Leu Val Ser Ser Thr Tyr Asp Leu Met Ser Ser Ala 
            20                  25                  30          


Tyr Leu Ser Thr Lys Asp Gln Tyr Pro Tyr Leu Lys Ser Val Cys Glu 
        35                  40                  45              


Met Ala Glu Asn Gly Val Lys Thr Ile Thr Ser Val Ala Met Thr Ser 
    50                  55                  60                  


Ala Leu Pro Ile Ile Gln Lys Leu Glu Pro Gln Ile Ala Val Ala Asn 
65                  70                  75                  80  


Thr Tyr Ala Cys Lys Gly Leu Asp Arg Ile Glu Glu Arg Leu Pro Ile 
                85                  90                  95      


Leu Asn Gln Pro Ser Thr Gln Ile Val Ala Asn Ala Lys Gly Ala Val 
            100                 105                 110         


Thr Gly Ala Lys Asp Ala Val Thr Thr Thr Val Thr Gly Ala Lys Asp 
        115                 120                 125             


Ser Val Ala Ser Thr Ile Thr Gly Val Met Asp Lys Thr Lys Gly Ala 
    130                 135                 140                 


Val Thr Gly Ser Val Glu Lys Thr Lys Ser Val Val Ser Gly Ser Ile 
145                 150                 155                 160 


Asn Thr Val Leu Gly Ser Arg Met Met Gln Leu Val Ser Ser Gly Val 
                165                 170                 175     


Glu Asn Ala Leu Thr Lys Ser Glu Leu Leu Val Glu Gln Tyr Leu Pro 
            180                 185                 190         


Leu Thr Glu Glu Glu Leu Glu Lys Glu Ala Lys Lys Val Glu Gly Phe 
        195                 200                 205             


Asp Leu Val Gln Lys Pro Ser Tyr Tyr Val Arg Leu Gly Ser Leu Ser 
    210                 215                 220                 


Thr Lys Leu His Ser Arg Ala Tyr Gln Gln Ala Leu Ser Arg Val Lys 
225                 230                 235                 240 


Glu Ala Lys Gln Lys Ser Gln Gln Thr Ile Ser Gln Leu His Ser Thr 
                245                 250                 255     


Val His Leu Ile Glu Phe Ala Arg Lys Asn Val Tyr Ser Ala Asn Gln 
            260                 265                 270         


Lys Ile Gln Asp Ala Gln Asp Lys Leu Tyr Leu Ser Trp Val Glu Trp 
        275                 280                 285             


Lys Arg Ser Ile Gly Tyr Asp Asp Thr Asp Glu Ser His Cys Ala Glu 
    290                 295                 300                 


His Ile Glu Ser Arg Thr Leu Ala Ile Ala Arg Asn Leu Thr Gln Gln 
305                 310                 315                 320 


Leu Gln Thr Thr Cys His Thr Leu Leu Ser Asn Ile Gln Gly Val Pro 
                325                 330                 335     


Gln Asn Ile Gln Asp Gln Ala Lys His Met Gly Val Met Ala Gly Asp 
            340                 345                 350         


Ile Tyr Ser Val Phe Arg Asn Ala Ala Ser Phe Lys Glu Val Ser Asp 
        355                 360                 365             


Ser Leu Leu Thr Ser Ser Lys Gly Gln Leu Gln Lys Met Lys Glu Ser 
    370                 375                 380                 


Leu Asp Asp Val Met Asp Tyr Leu Val Asn Asn Thr Pro Leu Asn Trp 
385                 390                 395                 400 


Leu Val Gly Pro Phe Tyr Pro Gln Leu Thr Glu Ser Gln Asn Ala Gln 
                405                 410                 415     


Asp Gln Gly Ala Glu Met Asp Lys Ser Ser Gln Glu Thr Gln Arg Ser 
            420                 425                 430         


Glu His Lys Thr His 
        435         


<210> 131
<211> 1950
<212> DNA
<213> Homo sapiens

<400> 131
tctggcattg caagcctcgc ttcgttgcca cttcccagct cttcccgcct tccgcggtat       60

aatcaacact acgagagata gagccgccta gaaccagtcc ggaggctgcg gctgcagaag      120

taccgcctgc ggagtaactg caaagatgct gtccgtgcgc gttgctgcgg ccgtggtccg      180

cgcccttcct cggcgggccg gactggtctc cagaaatgct ttgggttcat ctttcattgc      240

tgcaaggaac ttccatgcct ctaacactca tcttcaaaag actgggactg ctgagatgtc      300

ctctattctt gaagagcgta ttcttggagc tgatacctct gttgatcttg aagaaactgg      360

gcgtgtctta agtattggtg atggtattgc ccgcgtacat gggctgagga atgttcaagc      420

agaagaaatg gtagagtttt cttcaggctt aaagggtatg tccttgaact tggaacctga      480

caatgttggt gttgtcgtgt ttggaaatga taaactaatt aaggaaggag atatagtgaa      540

gaggacagga gccattgtgg acgttccagt tggtgaggag ctgttgggtc gtgtagttga      600

tgcccttggt aatgctattg atggaaaggg tccaattggt tccaagacgc gtaggcgagt      660

tggtctgaaa gcccccggta tcattcctcg aatttcagtg cgggaaccaa tgcagactgg      720

cattaaggct gtggatagct tggtgccaat tggtcgtggt cagcgtgaac tgattattgg      780

tgaccgacag actgggaaaa cctcaattgc tattgacaca atcattaacc agaaacgttt      840

caatgatgga tctgatgaaa agaagaagct gtactgtatt tatgttgcta ttggtcaaaa      900

gagatccact gttgcccagt tggtgaagag acttacagat gcagatgcca tgaagtacac      960

cattgtggtg tcggctacgg cctcggatgc tgccccactt cagtacctgg ctccttactc     1020

tggctgttcc atgggagagt attttagaga caatggcaaa catgctttga tcatctatga     1080

cgacttatcc aaacaggctg ttgcttaccg tcagatgtct ctgttgctcc gccgaccccc     1140

tggtcgtgag gcctatcctg gtgatgtgtt ctacctacac tcccggttgc tggagagagc     1200

agccaaaatg aacgatgctt ttggtggtgg ctccttgact gctttgccag tcatagaaac     1260

acaggctggt gatgtgtctg cttacattcc aacaaatgtc atttccatca ctgacggaca     1320

gatcttcttg gaaacagaat tgttctacaa aggtatccgc cctgcaatta acgttggtct     1380

gtctgtatct cgtgtcggat ccgctgccca aaccagggct atgaagcagg tagcaggtac     1440

catgaagctg gaattggctc agtatcgtga ggttgctgct tttgcccagt tcggttctga     1500

cctcgatgct gccactcaac aacttttgag tcgtggcgtg cgtctaactg agttgctgaa     1560

gcaaggacag tattctccca tggctattga agaacaagtg gctgttatct atgcgggtgt     1620

aaggggatat cttgataaac tggagcccag caagattaca aagtttgaga atgctttctt     1680

gtctcatgtc gtcagccagc accaagcctt gttgggcact atcagggctg atggaaagat     1740

ctcagaacaa tcagatgcaa agctgaaaga gattgtaaca aatttcttgg ctggatttga     1800

agcttaaact cctgtggatt cacatcaaat accagttcag ttttgtcatt gttctagtaa     1860

attagttcca tttgtaaaag ggttactctc atactcctta tgtacagaaa tcacatgaaa     1920

aataaaggtt ccataatgca tagttaaaaa                                      1950


<210> 132
<211> 553
<212> PRT
<213> Homo sapiens

<400> 132
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu 
    130                 135                 140                 


Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly 
145                 150                 155                 160 


Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala 
                165                 170                 175     


Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly 
            180                 185                 190         


Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu 
        195                 200                 205             


Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp 
    210                 215                 220                 


Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys 
225                 230                 235                 240 


Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val 
                245                 250                 255     


Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr 
            260                 265                 270         


Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu 
        275                 280                 285             


Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly 
    290                 295                 300                 


Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala 
305                 310                 315                 320 


Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala 
                325                 330                 335     


Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala 
            340                 345                 350         


Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro 
        355                 360                 365             


Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn 
    370                 375                 380                 


Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe 
385                 390                 395                 400 


Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg 
                405                 410                 415     


Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr 
            420                 425                 430         


Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln 
        435                 440                 445             


Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly 
    450                 455                 460                 


Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala 
465                 470                 475                 480 


Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu 
                485                 490                 495     


Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu 
            500                 505                 510         


Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala 
        515                 520                 525             


Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val 
    530                 535                 540                 


Thr Asn Phe Leu Ala Gly Phe Glu Ala 
545                 550             


<210> 133
<211> 1927
<212> DNA
<213> Homo sapiens

<400> 133
ggggcagtac ttccgggtca ggtgggccgg ctgtcttgac cttctttgcg gctcggccat       60

tttgtcccag tcagtccgga ggctgcggct gcagaagtac cgcctgcgga gtaactgcaa      120

agatgctgtc cgtgcgcgtt gctgcggccg tggtccgcgc ccttcctcgg cgggccggac      180

tggtctccag aaatgctttg ggttcatctt tcattgctgc aaggaacttc catgcctcta      240

acactcatct tcaaaagact gggactgctg agatgtcctc tattcttgaa gagcgtattc      300

ttggagctga tacctctgtt gatcttgaag aaactgggcg tgtcttaagt attggtgatg      360

gtattgcccg cgtacatggg ctgaggaatg ttcaagcaga agaaatggta gagttttctt      420

caggcttaaa gggtatgtcc ttgaacttgg aacctgacaa tgttggtgtt gtcgtgtttg      480

gaaatgataa actaattaag gaaggagata tagtgaagag gacaggagcc attgtggacg      540

ttccagttgg tgaggagctg ttgggtcgtg tagttgatgc ccttggtaat gctattgatg      600

gaaagggtcc aattggttcc aagacgcgta ggcgagttgg tctgaaagcc cccggtatca      660

ttcctcgaat ttcagtgcgg gaaccaatgc agactggcat taaggctgtg gatagcttgg      720

tgccaattgg tcgtggtcag cgtgaactga ttattggtga ccgacagact gggaaaacct      780

caattgctat tgacacaatc attaaccaga aacgtttcaa tgatggatct gatgaaaaga      840

agaagctgta ctgtatttat gttgctattg gtcaaaagag atccactgtt gcccagttgg      900

tgaagagact tacagatgca gatgccatga agtacaccat tgtggtgtcg gctacggcct      960

cggatgctgc cccacttcag tacctggctc cttactctgg ctgttccatg ggagagtatt     1020

ttagagacaa tggcaaacat gctttgatca tctatgacga cttatccaaa caggctgttg     1080

cttaccgtca gatgtctctg ttgctccgcc gaccccctgg tcgtgaggcc tatcctggtg     1140

atgtgttcta cctacactcc cggttgctgg agagagcagc caaaatgaac gatgcttttg     1200

gtggtggctc cttgactgct ttgccagtca tagaaacaca ggctggtgat gtgtctgctt     1260

acattccaac aaatgtcatt tccatcactg acggacagat cttcttggaa acagaattgt     1320

tctacaaagg tatccgccct gcaattaacg ttggtctgtc tgtatctcgt gtcggatccg     1380

ctgcccaaac cagggctatg aagcaggtag caggtaccat gaagctggaa ttggctcagt     1440

atcgtgaggt tgctgctttt gcccagttcg gttctgacct cgatgctgcc actcaacaac     1500

ttttgagtcg tggcgtgcgt ctaactgagt tgctgaagca aggacagtat tctcccatgg     1560

ctattgaaga acaagtggct gttatctatg cgggtgtaag gggatatctt gataaactgg     1620

agcccagcaa gattacaaag tttgagaatg ctttcttgtc tcatgtcgtc agccagcacc     1680

aagccttgtt gggcactatc agggctgatg gaaagatctc agaacaatca gatgcaaagc     1740

tgaaagagat tgtaacaaat ttcttggctg gatttgaagc ttaaactcct gtggattcac     1800

atcaaatacc agttcagttt tgtcattgtt ctagtaaatt agttccattt gtaaaagggt     1860

tactctcata ctccttatgt acagaaatca catgaaaaat aaaggttcca taatgcatag     1920

ttaaaaa                                                               1927


<210> 134
<211> 553
<212> PRT
<213> Homo sapiens

<400> 134
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu 
    130                 135                 140                 


Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly 
145                 150                 155                 160 


Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala 
                165                 170                 175     


Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly 
            180                 185                 190         


Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu 
        195                 200                 205             


Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp 
    210                 215                 220                 


Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys 
225                 230                 235                 240 


Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val 
                245                 250                 255     


Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr 
            260                 265                 270         


Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu 
        275                 280                 285             


Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly 
    290                 295                 300                 


Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala 
305                 310                 315                 320 


Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala 
                325                 330                 335     


Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala 
            340                 345                 350         


Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro 
        355                 360                 365             


Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn 
    370                 375                 380                 


Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe 
385                 390                 395                 400 


Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg 
                405                 410                 415     


Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr 
            420                 425                 430         


Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln 
        435                 440                 445             


Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly 
    450                 455                 460                 


Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala 
465                 470                 475                 480 


Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu 
                485                 490                 495     


Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu 
            500                 505                 510         


Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala 
        515                 520                 525             


Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val 
    530                 535                 540                 


Thr Asn Phe Leu Ala Gly Phe Glu Ala 
545                 550             


<210> 135
<211> 1861
<212> DNA
<213> Homo sapiens

<400> 135
ggggcagtac ttccgggtca ggtgggccgg ctgtcttgac cttctttgcg gctcggccat       60

tttgtcccag tcagtccgga ggctgcggct gcagaagtac cgcctgcgga gtaactgcaa      120

agatgctgtc cgtgcgcgtt gctgcggccg tggtccgcgc ccttcctcgg cgggccggac      180

tggtctccag aaatgctttg ggttcatctt tcattgctgc aaggaacttc catgcctcta      240

acactcatct tcaaaagact gggactgctg agatgtcctc tattcttgaa gagcgtattc      300

ttggagctga tacctctgtt gatcttgaag aaactgggcg tgtcttaagt attggtgatg      360

gtattgcccg cgtacatggg ctgaggaatg ttcaagcaga agaaatggta gagttttctt      420

caggcttaaa gggtatgtcc ttgaacttgg aacctgacaa tgttggtgtt gtcgtgtttg      480

gaaatgataa actaattaag gaaggagata tagtgaagag gacaggagcc attgtggacg      540

gtccaattgg ttccaagacg cgtaggcgag ttggtctgaa agcccccggt atcattcctc      600

gaatttcagt gcgggaacca atgcagactg gcattaaggc tgtggatagc ttggtgccaa      660

ttggtcgtgg tcagcgtgaa ctgattattg gtgaccgaca gactgggaaa acctcaattg      720

ctattgacac aatcattaac cagaaacgtt tcaatgatgg atctgatgaa aagaagaagc      780

tgtactgtat ttatgttgct attggtcaaa agagatccac tgttgcccag ttggtgaaga      840

gacttacaga tgcagatgcc atgaagtaca ccattgtggt gtcggctacg gcctcggatg      900

ctgccccact tcagtacctg gctccttact ctggctgttc catgggagag tattttagag      960

acaatggcaa acatgctttg atcatctatg acgacttatc caaacaggct gttgcttacc     1020

gtcagatgtc tctgttgctc cgccgacccc ctggtcgtga ggcctatcct ggtgatgtgt     1080

tctacctaca ctcccggttg ctggagagag cagccaaaat gaacgatgct tttggtggtg     1140

gctccttgac tgctttgcca gtcatagaaa cacaggctgg tgatgtgtct gcttacattc     1200

caacaaatgt catttccatc actgacggac agatcttctt ggaaacagaa ttgttctaca     1260

aaggtatccg ccctgcaatt aacgttggtc tgtctgtatc tcgtgtcgga tccgctgccc     1320

aaaccagggc tatgaagcag gtagcaggta ccatgaagct ggaattggct cagtatcgtg     1380

aggttgctgc ttttgcccag ttcggttctg acctcgatgc tgccactcaa caacttttga     1440

gtcgtggcgt gcgtctaact gagttgctga agcaaggaca gtattctccc atggctattg     1500

aagaacaagt ggctgttatc tatgcgggtg taaggggata tcttgataaa ctggagccca     1560

gcaagattac aaagtttgag aatgctttct tgtctcatgt cgtcagccag caccaagcct     1620

tgttgggcac tatcagggct gatggaaaga tctcagaaca atcagatgca aagctgaaag     1680

agattgtaac aaatttcttg gctggatttg aagcttaaac tcctgtggat tcacatcaaa     1740

taccagttca gttttgtcat tgttctagta aattagttcc atttgtaaaa gggttactct     1800

catactcctt atgtacagaa atcacatgaa aaataaaggt tccataatgc atagttaaaa     1860

a                                                                     1861


<210> 136
<211> 531
<212> PRT
<213> Homo sapiens

<400> 136
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Gly Pro Ile Gly Ser 
    130                 135                 140                 


Lys Thr Arg Arg Arg Val Gly Leu Lys Ala Pro Gly Ile Ile Pro Arg 
145                 150                 155                 160 


Ile Ser Val Arg Glu Pro Met Gln Thr Gly Ile Lys Ala Val Asp Ser 
                165                 170                 175     


Leu Val Pro Ile Gly Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg 
            180                 185                 190         


Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp Thr Ile Ile Asn Gln Lys 
        195                 200                 205             


Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys Lys Leu Tyr Cys Ile Tyr 
    210                 215                 220                 


Val Ala Ile Gly Gln Lys Arg Ser Thr Val Ala Gln Leu Val Lys Arg 
225                 230                 235                 240 


Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr Ile Val Val Ser Ala Thr 
                245                 250                 255     


Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu Ala Pro Tyr Ser Gly Cys 
            260                 265                 270         


Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly Lys His Ala Leu Ile Ile 
        275                 280                 285             


Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala Tyr Arg Gln Met Ser Leu 
    290                 295                 300                 


Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly Asp Val Phe 
305                 310                 315                 320 


Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Met Asn Asp Ala 
                325                 330                 335     


Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro Val Ile Glu Thr Gln Ala 
            340                 345                 350         


Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser Ile Thr Asp 
        355                 360                 365             


Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe Tyr Lys Gly Ile Arg Pro 
    370                 375                 380                 


Ala Ile Asn Val Gly Leu Ser Val Ser Arg Val Gly Ser Ala Ala Gln 
385                 390                 395                 400 


Thr Arg Ala Met Lys Gln Val Ala Gly Thr Met Lys Leu Glu Leu Ala 
                405                 410                 415     


Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln Phe Gly Ser Asp Leu Asp 
            420                 425                 430         


Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly Val Arg Leu Thr Glu Leu 
        435                 440                 445             


Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala Ile Glu Glu Gln Val Ala 
    450                 455                 460                 


Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu Asp Lys Leu Glu Pro Ser 
465                 470                 475                 480 


Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu Ser His Val Val Ser Gln 
                485                 490                 495     


His Gln Ala Leu Leu Gly Thr Ile Arg Ala Asp Gly Lys Ile Ser Glu 
            500                 505                 510         


Gln Ser Asp Ala Lys Leu Lys Glu Ile Val Thr Asn Phe Leu Ala Gly 
        515                 520                 525             


Phe Glu Ala 
    530     


<210> 137
<211> 2000
<212> DNA
<213> Homo sapiens

<400> 137
ggggcagtac ttccgggtca ggtgggccgg ctgtcttgac cttctttgcg gctcggccat       60

tttgtcccag tcagtccgga ggctgcggct gcagaagtac cgcctgcgga gtaactgcaa      120

agatgctgtc cgtgcgcgtt gctgcggccg tggtccgcgc ccttcctcgg cgggccggac      180

tggtctccag aaatgctttg ggttcatctt tcattgctgc aaggaacttc catgcctcta      240

acactcatct tcaaaagact ggtaagttat tatttctcag tctacgccgc acttactaga      300

tgaagatata aattacatac atcgtataac tgtgggactg ctgagatgtc ctctattctt      360

gaagagcgta ttcttggagc tgatacctct gttgatcttg aagaaactgg gcgtgtctta      420

agtattggtg atggtattgc ccgcgtacat gggctgagga atgttcaagc agaagaaatg      480

gtagagtttt cttcaggctt aaagggtatg tccttgaact tggaacctga caatgttggt      540

gttgtcgtgt ttggaaatga taaactaatt aaggaaggag atatagtgaa gaggacagga      600

gccattgtgg acgttccagt tggtgaggag ctgttgggtc gtgtagttga tgcccttggt      660

aatgctattg atggaaaggg tccaattggt tccaagacgc gtaggcgagt tggtctgaaa      720

gcccccggta tcattcctcg aatttcagtg cgggaaccaa tgcagactgg cattaaggct      780

gtggatagct tggtgccaat tggtcgtggt cagcgtgaac tgattattgg tgaccgacag      840

actgggaaaa cctcaattgc tattgacaca atcattaacc agaaacgttt caatgatgga      900

tctgatgaaa agaagaagct gtactgtatt tatgttgcta ttggtcaaaa gagatccact      960

gttgcccagt tggtgaagag acttacagat gcagatgcca tgaagtacac cattgtggtg     1020

tcggctacgg cctcggatgc tgccccactt cagtacctgg ctccttactc tggctgttcc     1080

atgggagagt attttagaga caatggcaaa catgctttga tcatctatga cgacttatcc     1140

aaacaggctg ttgcttaccg tcagatgtct ctgttgctcc gccgaccccc tggtcgtgag     1200

gcctatcctg gtgatgtgtt ctacctacac tcccggttgc tggagagagc agccaaaatg     1260

aacgatgctt ttggtggtgg ctccttgact gctttgccag tcatagaaac acaggctggt     1320

gatgtgtctg cttacattcc aacaaatgtc atttccatca ctgacggaca gatcttcttg     1380

gaaacagaat tgttctacaa aggtatccgc cctgcaatta acgttggtct gtctgtatct     1440

cgtgtcggat ccgctgccca aaccagggct atgaagcagg tagcaggtac catgaagctg     1500

gaattggctc agtatcgtga ggttgctgct tttgcccagt tcggttctga cctcgatgct     1560

gccactcaac aacttttgag tcgtggcgtg cgtctaactg agttgctgaa gcaaggacag     1620

tattctccca tggctattga agaacaagtg gctgttatct atgcgggtgt aaggggatat     1680

cttgataaac tggagcccag caagattaca aagtttgaga atgctttctt gtctcatgtc     1740

gtcagccagc accaagcctt gttgggcact atcagggctg atggaaagat ctcagaacaa     1800

tcagatgcaa agctgaaaga gattgtaaca aatttcttgg ctggatttga agcttaaact     1860

cctgtggatt cacatcaaat accagttcag ttttgtcatt gttctagtaa attagttcca     1920

tttgtaaaag ggttactctc atactcctta tgtacagaaa tcacatgaaa aataaaggtt     1980

ccataatgca tagttaaaaa                                                 2000


<210> 138
<211> 503
<212> PRT
<213> Homo sapiens

<400> 138
Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr Ser Val 
1               5                   10                  15      


Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly Ile Ala 
            20                  25                  30          


Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val Glu Phe 
        35                  40                  45              


Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp Asn Val 
    50                  55                  60                  


Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly Asp Ile 
65                  70                  75                  80  


Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu Glu Leu 
                85                  90                  95      


Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly Lys Gly 
            100                 105                 110         


Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala Pro Gly 
        115                 120                 125             


Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly Ile Lys 
    130                 135                 140                 


Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu Leu Ile 
145                 150                 155                 160 


Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp Thr Ile 
                165                 170                 175     


Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys Lys Leu 
            180                 185                 190         


Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val Ala Gln 
        195                 200                 205             


Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr Ile Val 
    210                 215                 220                 


Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu Ala Pro 
225                 230                 235                 240 


Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly Lys His 
                245                 250                 255     


Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala Tyr Arg 
            260                 265                 270         


Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro 
        275                 280                 285             


Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys 
    290                 295                 300                 


Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro Val Ile 
305                 310                 315                 320 


Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn Val Ile 
                325                 330                 335     


Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe Tyr Lys 
            340                 345                 350         


Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg Val Gly 
        355                 360                 365             


Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr Met Lys 
    370                 375                 380                 


Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln Phe Gly 
385                 390                 395                 400 


Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly Val Arg 
                405                 410                 415     


Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala Ile Glu 
            420                 425                 430         


Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu Asp Lys 
        435                 440                 445             


Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu Ser His 
    450                 455                 460                 


Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala Asp Gly 
465                 470                 475                 480 


Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val Thr Asn 
                485                 490                 495     


Phe Leu Ala Gly Phe Glu Ala 
            500             


<210> 139
<211> 2263
<212> DNA
<213> Homo sapiens

<400> 139
ggggcagtac ttccgggtca ggtgggccgg ctgtcttgac cttctttgcg gctcggccat       60

tttgtcccag tcagtccgga ggctgcggct gcagaagtac cgcctgcgga gtaactgcaa      120

agatgctgtc cgtgcgcgtt gctgcggccg tggtccgcgc ccttcctcgg cgggccggac      180

tggtgagcac cgaaggccgg catgatgcag gcggccgggt ggggctgcag ggtggtggtg      240

cgccggctcg ggcgctctct gcaggagggc gaggggctgt ggcgaatgcc gccatcttgc      300

acccgtggct tctccggctg gacagagcag gcgacacagg tgcccttttg ctcgtcacct      360

gcgcagaggc agaatggtac agggcagaca gttaactcga tggtgtccag agacagggcc      420

tcaagattcc tgtcttcggc tgacagcggc cctagaaggg ggatcttggg tgaaggtcag      480

ggcttgggcg ctagctctcc gaggcctgtt ctgaatcggt ctccagaaat gctttgggtt      540

catctttcat tgctgcaagg aacttccatg cctctaacac tcatcttcaa aagactggga      600

ctgctgagat gtcctctatt cttgaagagc gtattcttgg agctgatacc tctgttgatc      660

ttgaagaaac tgggcgtgtc ttaagtattg gtgatggtat tgcccgcgta catgggctga      720

ggaatgttca agcagaagaa atggtagagt tttcttcagg cttaaagggt atgtccttga      780

acttggaacc tgacaatgtt ggtgttgtcg tgtttggaaa tgataaacta attaaggaag      840

gagatatagt gaagaggaca ggagccattg tggacgttcc agttggtgag gagctgttgg      900

gtcgtgtagt tgatgccctt ggtaatgcta ttgatggaaa gggtccaatt ggttccaaga      960

cgcgtaggcg agttggtctg aaagcccccg gtatcattcc tcgaatttca gtgcgggaac     1020

caatgcagac tggcattaag gctgtggata gcttggtgcc aattggtcgt ggtcagcgtg     1080

aactgattat tggtgaccga cagactggga aaacctcaat tgctattgac acaatcatta     1140

accagaaacg tttcaatgat ggatctgatg aaaagaagaa gctgtactgt atttatgttg     1200

ctattggtca aaagagatcc actgttgccc agttggtgaa gagacttaca gatgcagatg     1260

ccatgaagta caccattgtg gtgtcggcta cggcctcgga tgctgcccca cttcagtacc     1320

tggctcctta ctctggctgt tccatgggag agtattttag agacaatggc aaacatgctt     1380

tgatcatcta tgacgactta tccaaacagg ctgttgctta ccgtcagatg tctctgttgc     1440

tccgccgacc ccctggtcgt gaggcctatc ctggtgatgt gttctaccta cactcccggt     1500

tgctggagag agcagccaaa atgaacgatg cttttggtgg tggctccttg actgctttgc     1560

cagtcataga aacacaggct ggtgatgtgt ctgcttacat tccaacaaat gtcatttcca     1620

tcactgacgg acagatcttc ttggaaacag aattgttcta caaaggtatc cgccctgcaa     1680

ttaacgttgg tctgtctgta tctcgtgtcg gatccgctgc ccaaaccagg gctatgaagc     1740

aggtagcagg taccatgaag ctggaattgg ctcagtatcg tgaggttgct gcttttgccc     1800

agttcggttc tgacctcgat gctgccactc aacaactttt gagtcgtggc gtgcgtctaa     1860

ctgagttgct gaagcaagga cagtattctc ccatggctat tgaagaacaa gtggctgtta     1920

tctatgcggg tgtaagggga tatcttgata aactggagcc cagcaagatt acaaagtttg     1980

agaatgcttt cttgtctcat gtcgtcagcc agcaccaagc cttgttgggc actatcaggg     2040

ctgatggaaa gatctcagaa caatcagatg caaagctgaa agagattgta acaaatttct     2100

tggctggatt tgaagcttaa actcctgtgg attcacatca aataccagtt cagttttgtc     2160

attgttctag taaattagtt ccatttgtaa aagggttact ctcatactcc ttatgtacag     2220

aaatcacatg aaaaataaag gttccataat gcatagttaa aaa                       2263


<210> 140
<211> 503
<212> PRT
<213> Homo sapiens

<400> 140
Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr Ser Val 
1               5                   10                  15      


Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly Ile Ala 
            20                  25                  30          


Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val Glu Phe 
        35                  40                  45              


Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp Asn Val 
    50                  55                  60                  


Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly Asp Ile 
65                  70                  75                  80  


Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu Glu Leu 
                85                  90                  95      


Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly Lys Gly 
            100                 105                 110         


Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala Pro Gly 
        115                 120                 125             


Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly Ile Lys 
    130                 135                 140                 


Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu Leu Ile 
145                 150                 155                 160 


Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp Thr Ile 
                165                 170                 175     


Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys Lys Leu 
            180                 185                 190         


Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val Ala Gln 
        195                 200                 205             


Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr Ile Val 
    210                 215                 220                 


Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu Ala Pro 
225                 230                 235                 240 


Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly Lys His 
                245                 250                 255     


Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala Tyr Arg 
            260                 265                 270         


Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro 
        275                 280                 285             


Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys 
    290                 295                 300                 


Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro Val Ile 
305                 310                 315                 320 


Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn Val Ile 
                325                 330                 335     


Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe Tyr Lys 
            340                 345                 350         


Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg Val Gly 
        355                 360                 365             


Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr Met Lys 
    370                 375                 380                 


Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln Phe Gly 
385                 390                 395                 400 


Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly Val Arg 
                405                 410                 415     


Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala Ile Glu 
            420                 425                 430         


Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu Asp Lys 
        435                 440                 445             


Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu Ser His 
    450                 455                 460                 


Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala Asp Gly 
465                 470                 475                 480 


Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val Thr Asn 
                485                 490                 495     


Phe Leu Ala Gly Phe Glu Ala 
            500             


<210> 141
<211> 2932
<212> DNA
<213> Homo sapiens

<400> 141
aaatagtcta ctttccggta gcggtgccag ggcagtggcc taatacggaa ctccatttcc       60

cggcgtgcct cgcggaggcc gctgaactca gaagcgggag gccggttccg gttgcatcag      120

cgagggattc acggcgaaat gagactgttc gtgagtgatg gcgtcccggg ttgcttgccg      180

gtgctggccg ccgccgggag agcccggggc agagcagagg tgctcatcag cactgtaggc      240

ccggaagatt gtgtggtccc gttcctgacc cggcctaagg tccctgtctt gcagctggat      300

agcggcaact acctcttctc cactagtgca atctgccgat attttttttt gttatctggc      360

tgggagcaag atgacctcac taaccagtgg ctggaatggg aagcgacaga gctgcagcca      420

gctttgtctg ctgccctgta ctatttagtg gtccaaggca agaaggggga agatgttctt      480

ggttcagtgc ggagagccct gactcacatt gaccacagct tgagtcgtca gaactgtcct      540

ttcctggctg gggagacaga atctctagcc gacattgttt tgtggggagc cctataccca      600

ttactgcaag atcccgccta cctccctgag gagctgagtg ccctgcacag ctggttccag      660

acactgagta cccaggaacc atgtcagcga gctgcagaga ctgtactgaa acagcaaggt      720

gtcctggctc tccggcctta cctccaaaag cagccccagc ccagccccgc tgagggaagg      780

gctgtcacca atgagcctga ggaggaggag ctggctaccc tatctgagga ggagattgct      840

atggctgtta ctgcttggga gaagggccta gaaagtttgc ccccgctgcg gccccagcag      900

aatccagtgt tgcctgtggc tggagaaagg aatgtgctca tcaccagtgc cctcccttac      960

gtcaacaatg tcccccacct tgggaacatc attggttgtg tgctcagtgc cgatgtcttt     1020

gccaggtact ctcgcctccg ccagtggaac accctctatc tgtgtgggac agatgagtat     1080

ggtacagcaa cagagaccaa ggctctggag gagggactaa ccccccagga gatctgcgac     1140

aagtaccaca tcatccatgc tgacatctac cgctggttta acatttcgtt tgatattttt     1200

ggtcgcacca ccactccaca gcagaccaaa atcacccagg acattttcca gcagttgctg     1260

aaacgaggtt ttgtgctgca agatactgtg gagcaactgc gatgtgagca ctgtgctcgc     1320

ttcctggctg accgcttcgt ggagggcgtg tgtcccttct gtggctatga ggaggctcgg     1380

ggtgaccagt gtgacaagtg tggcaagctc atcaatgctg tcgagcttaa gaagcctcag     1440

tgtaaagtct gccgatcatg ccctgtggtg cagtcgagcc agcacctgtt tctggacctg     1500

cctaagctgg agaagcgact ggaggagtgg ttggggagga cattgcctgg cagtgactgg     1560

acacccaatg cccagtttat cacccgttct tggcttcggg atggcctcaa gccacgctgc     1620

ataacccgag acctcaaatg gggaacccct gtacccttag aaggttttga agacaaggta     1680

ttctatgtct ggtttgatgc cactattggc tatctgtcca tcacagccaa ctacacagac     1740

cagtgggaga gatggtggaa gaacccagag caagtggacc tgtatcagtt catggccaaa     1800

gacaatgttc ctttccatag cttagtcttt ccttgctcag ccctaggagc tgaggataac     1860

tataccttgg tcagccacct cattgctaca gagtacctga actatgagga tgggaaattc     1920

tctaagagcc gcggtgtggg agtgtttggg gacatggccc aggacacggg gatccctgct     1980

gacatctggc gcttctatct gctgtacatt cggcctgagg gccaggacag tgctttctcc     2040

tggacggacc tgctgctgaa gaataattct gagctgctta acaacctggg caacttcatc     2100

aacagagctg ggatgtttgt gtctaagttc tttgggggct atgtgcctga gatggtgctc     2160

acccctgatg atcagcgcct gctggcccat gtcaccctgg agctccagca ctatcaccag     2220

ctacttgaga aggttcggat ccgggatgcc ttgcgcagta tcctcaccat atctcgacat     2280

ggcaaccaat atattcaggt gaatgagccc tggaagcgga ttaaaggcag tgaggctgac     2340

aggcaacggg caggaacagt gactggcttg gcagtgaata tagctgcctt gctctctgtc     2400

atgcttcagc cttacatgcc cacggttagt gccacaatcc aggcccagct gcagctccca     2460

cctccagcct gcagtatcct gctgacaaac ttcctgtgta ccttaccagc aggacaccag     2520

attggcacag tcagtccctt gttccaaaaa ttggaaaatg accagattga aagtttaagg     2580

cagcgctttg gagggggcca ggcaaaaacg tccccgaagc cagcagttgt agagactgtt     2640

acaacagcca agccacagca gatacaagcg ctgatggatg aagtgacaaa acaaggaaac     2700

attgtccgag aactgaaagc acaaaaggca gacaagaacg aggttgctgc ggaggtggcg     2760

aaactcttgg atctaaagaa acagttggct gtagctgagg ggaaaccccc tgaagcccct     2820

aaaggcaaga agaaaaagta aaagaccttg gctcatagaa agtcacttta atagataggg     2880

acagtaataa ataaatgtac aatctctata tacaaaaaaa aaaaaaaaaa aa             2932


<210> 142
<211> 900
<212> PRT
<213> Homo sapiens

<400> 142
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu 
1               5                   10                  15      


Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr 
            20                  25                  30          


Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val 
        35                  40                  45              


Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala 
    50                  55                  60                  


Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu 
65                  70                  75                  80  


Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu 
                85                  90                  95      


Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp 
            100                 105                 110         


Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu 
        115                 120                 125             


Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala 
    130                 135                 140                 


Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala 
145                 150                 155                 160 


Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu 
                165                 170                 175     


Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln 
            180                 185                 190         


Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro 
        195                 200                 205             


Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu 
    210                 215                 220                 


Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp 
225                 230                 235                 240 


Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro 
                245                 250                 255     


Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu 
            260                 265                 270         


Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val 
        275                 280                 285             


Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn 
    290                 295                 300                 


Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr 
305                 310                 315                 320 


Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr 
                325                 330                 335     


His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp 
            340                 345                 350         


Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp 
        355                 360                 365             


Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val 
    370                 375                 380                 


Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe 
385                 390                 395                 400 


Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp 
                405                 410                 415     


Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys 
            420                 425                 430         


Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln 
        435                 440                 445             


His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp 
    450                 455                 460                 


Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe 
465                 470                 475                 480 


Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr 
                485                 490                 495     


Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp 
            500                 505                 510         


Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser Ile 
        515                 520                 525             


Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro Glu 
    530                 535                 540                 


Gln Val Asp Leu Tyr Gln Phe Met Ala Lys Asp Asn Val Pro Phe His 
545                 550                 555                 560 


Ser Leu Val Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr Thr 
                565                 570                 575     


Leu Val Ser His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly 
            580                 585                 590         


Lys Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln 
        595                 600                 605             


Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile 
    610                 615                 620                 


Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu 
625                 630                 635                 640 


Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg 
                645                 650                 655     


Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met 
            660                 665                 670         


Val Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu 
        675                 680                 685             


Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala 
    690                 695                 700                 


Leu Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln 
705                 710                 715                 720 


Val Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln 
                725                 730                 735     


Arg Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu 
            740                 745                 750         


Ser Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln 
        755                 760                 765             


Ala Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn 
    770                 775                 780                 


Phe Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro 
785                 790                 795                 800 


Leu Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg 
                805                 810                 815     


Phe Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu 
            820                 825                 830         


Thr Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu 
        835                 840                 845             


Val Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala 
    850                 855                 860                 


Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys 
865                 870                 875                 880 


Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly 
                885                 890                 895     


Lys Lys Lys Lys 
            900 


<210> 143
<211> 4693
<212> DNA
<213> Homo sapiens

<400> 143
attccgagta cgagaaagcg aaaaagccca gactgaaaag ggtactgaga aattacgact       60

agtcttaaat gctcccttcg cttctcgggc ctcgccacac cgcgcaggcg ccccactggt      120

ccttaactct gttctttgac ctcctgcccc agccccctcc tcttcagcca cctagcgact      180

cttccggtgc tgtgaaggcg gttccggttc gcggcggttc ccgggttttg cgttccgcgc      240

ccggccggaa accccttcgc atggcagccg gttccggttc ggactttgta tctttgctaa      300

agtcagtgat gtgaaaagac ttgaaatgga tgatattgct gataggatga ggatggatgc      360

tggagaagtg actttagtga accacaactc cgtattcaaa acccacctcc tgccacaaac      420

aggttttcca gaggaccagc tttcgctttc tgaccagcag attttatctt ccaggcaagg      480

acatttggac cgatctttta catgttccac aagaagtgca gcttataatc caagctatta      540

ctcagataat ccttcctcag acagttttct tggctcaggc gatttaagaa cctttggcca      600

gagtgcaaat ggccaatgga gaaattctac cccatcgtca agctcatctt tacaaaaatc      660

aagaaacagc cgaagtcttt acctcgaaac ccgaaagacc tcaagtggat tatcaaacag      720

ttttgcggga aagtcaaacc atcactgcca tgtatctgca tatgaaaaat cttttcctat      780

taaacctgtt ccaagtccat cttggagtgg ttcatgtcgt cgaagtcttt tgagccccaa      840

gaaaactcag aggcgacatg ttagtacagc agaagagaca gttcaagaag aagaaagaga      900

gatttacaga cagctgctac agatggtcac agggaaacag tttactatag ccaaacccac      960

cacacatttt cctttacacc tgtctcgatg tcttagttcc agtaaaaata ctttgaaaga     1020

ctcactgttt aaaaatggaa actcttgtgc atctcagatc attggctctg atacttcatc     1080

atctggatct gccagcattt taactaacca ggaacagctg tcccacagtg tatattccct     1140

atcttcttat accccagatg ttgcatttgg atccaaagat tctggtactc ttcatcatcc     1200

ccatcatcac cactctgttc cacatcagcc agataactta gcagcttcaa atacacaatc     1260

tgaaggatca gactctgtga ttttactgaa agtgaaagat tcccagactc caactcccag     1320

ttctactttc ttccaggcag agctgtggat caaagaatta actagtgttt atgattctcg     1380

agcacgagaa agattgcgcc agattgaaga acagaaggca ttggccttac agcttcaaaa     1440

ccagagattg caggagcggg aacattcagt acatgattca gtagaactac atcttcgtgt     1500

acctcttgaa aaggagattc ctgttactgt tgtccaagaa acacaaaaaa aaggtcataa     1560

attaactgat agtgaagatg aatttcctga aattacagag gaaatggaga aagaaataaa     1620

gaatgtattt cgtaatggga atcaggatga agttctcagt gaagcatttc gcctgaccat     1680

tacacgcaaa gatattcaaa ctctaaacca tctgaattgg ctcaatgatg agatcatcaa     1740

tttctacatg aatatgctga tggagcgaag taaagagaag ggcttgccaa gtgtgcatgc     1800

atttaatacc tttttcttca ctaaattaaa aacggctggt tatcaggcag tgaaacgttg     1860

gacaaagaaa gtagatgtat tttctgttga cattcttttg gtgcccattc acctgggagt     1920

acactggtgt ctagctgttg tggactttag aaagaagaat attacctatt acgactccat     1980

gggtgggata aacaatgaag cctgcagaat actcttgcaa tacctaaagc aagaaagcat     2040

tgacaagaaa aggaaagagt ttgacaccaa tggctggcag cttttcagca agaaaagcca     2100

ggagattcct cagcagatga atggaagtga ctgtgggatg tttgcctgca aatatgctga     2160

ctgtattacc aaagacagac caatcaactt cacacagcaa cacatgccat acttccggaa     2220

gcggatggtc tgggagatcc tccaccgaaa actcttgtga agactgtctc acttagcaga     2280

ccttgaccat gtgggggacc agctctttgt tgtctacagc cagagacctt ggaaacagct     2340

gctcccagcc ctctgctgtt gtaacaccct tgatcctgga ccaggccctg gcgagatgca     2400

ttcacaagca catctgcctt tccttttgta tctcagatac tatttttgca aagaaacttt     2460

ggtgctgtga aaggggtgag ggacatccct aagctgaaga gagagactgc ttttcacttc     2520

ttcagttctg ccatcttgtt ttcaaagggc tccagcctca ctcagtccct aattatggga     2580

ctgagaaaag cttggaaaga atcttggttt catataaatt cttgttgtta ggccttacta     2640

agaagtagga aagggcatgg gcaaaaggta gggataaaaa ccaccagcat atacatggac     2700

atacacacac acccacacac acaaacacac acacacacac aattttcacg atgtatggtc     2760

aggaatgtga ctgtaaactg gactttgggg cccaggcata agtcccttcc tccaggacct     2820

ttcctattta tatgtcccta tacaaaatcc atctgctttt atacgtagct gttttatcat     2880

ctgtagcttc atcctatccg gaggcacagc acatgagccc tggacaggtc ccaaagttcc     2940

aagcagtcct ttccgtgaaa gcaggggttt gcatgtgcta ccaacacatg atacggggaa     3000

gacccaccca gggagcggtt tcagtggcgc aacaaagcac cacttttact gttgcctact     3060

tctgaccaag aagaaaaagg accttagtat ttagcataaa attccagcgc tggatgaatg     3120

cagatctagt ttggtctgtg gctagtttaa atatgtttct aaccacagag aatttcatat     3180

atatatacat atatatatac acatacatat atatatatat atatgtatgt ataaaatttc     3240

acagggatat gctttttttt ttaaagactg aatgtgttca ccatttagcc tgtagattta     3300

tttccatttt ccaaattcca gcacacagag atcccagccc ctatgagtag ggtgtttgtg     3360

gactacctaa tggaatattt ttgaggcctg gatgaacttt gccatatggg tagaggttac     3420

agagggaggt gatattttca gctaaaaaaa aaaacgggtg gagtttggac tgatcaactt     3480

gagatttaaa aactgctatt ccttttgttc tttctagcat ctctccccac cctctgagag     3540

ctcctcaggc ttagatagtg aagtgatcaa atgccagtgt cattttgtac ttaagttcca     3600

aagtaggaac attttatact tttttctgta ttgtaatagg tagttttgta tgaaatcttt     3660

tctcctctcc cgttgtaccg cattctttcc agcattgtgc tttttccctg ggcttatttg     3720

aaaattttac tgttttatac aagctcgttt agtacatttt tctatgtttt accacaagtt     3780

acaatttgaa aagaaaacta ttttttttaa atattccatt gttaactgaa tgttactgtt     3840

tccactccag caactacatg tcctcccttc aactgcctgc cttttgggga aagaccacct     3900

tttgtgtgtt tgttttttct ctctctttct ttccctttct ctttctatct ctctttattt     3960

ttctttcttt ttctttgttt ttgagttttc tataggaaat aaatagcttt ctatatatga     4020

gttgctgggg accttcacat tctcttttag aaagctgtgg catgcagtct cattgcagga     4080

ctcctggaat attgtctggt tcttggtatt tactgtatgt aagcaacaac ttgaaaggtg     4140

gcaatatggt gtcgatttgg actatgaatc aaaagacctt tttcaggttc tttcactatt     4200

gtctggggga ctcagaacaa gattgttctc tgtatttatt gtttgtccat ttaggtaaca     4260

tctgtcttac cttcctcaca gactttgtac agaccaaagc aacaaatatt tattgccatg     4320

tatagcagaa aatgaaacat gcaacaaaag cactttgaaa aatatataag gaattgttga     4380

gcctgtctga atttgggccc cctttctgac taatgcagtt ttgcacaagg tagaagttag     4440

tgaccctgag accatcttac caccctggac ctggtccaaa tacagactta cacagtggac     4500

cattctttcc tgagctagcc aacaagagca ggagtagtat ctggaaactt tcccctttgt     4560

ttaggggtag gctttgatga ccaggaaaaa aaaaaaggta tttctgcatt ttatggccca     4620

aaggcatgtt attaatatct tatgtaattt actttaaact aaataagact tttttctcct     4680

gtgtaaaaaa aaa                                                        4693


<210> 144
<211> 644
<212> PRT
<213> Homo sapiens

<400> 144
Met Asp Asp Ile Ala Asp Arg Met Arg Met Asp Ala Gly Glu Val Thr 
1               5                   10                  15      


Leu Val Asn His Asn Ser Val Phe Lys Thr His Leu Leu Pro Gln Thr 
            20                  25                  30          


Gly Phe Pro Glu Asp Gln Leu Ser Leu Ser Asp Gln Gln Ile Leu Ser 
        35                  40                  45              


Ser Arg Gln Gly His Leu Asp Arg Ser Phe Thr Cys Ser Thr Arg Ser 
    50                  55                  60                  


Ala Ala Tyr Asn Pro Ser Tyr Tyr Ser Asp Asn Pro Ser Ser Asp Ser 
65                  70                  75                  80  


Phe Leu Gly Ser Gly Asp Leu Arg Thr Phe Gly Gln Ser Ala Asn Gly 
                85                  90                  95      


Gln Trp Arg Asn Ser Thr Pro Ser Ser Ser Ser Ser Leu Gln Lys Ser 
            100                 105                 110         


Arg Asn Ser Arg Ser Leu Tyr Leu Glu Thr Arg Lys Thr Ser Ser Gly 
        115                 120                 125             


Leu Ser Asn Ser Phe Ala Gly Lys Ser Asn His His Cys His Val Ser 
    130                 135                 140                 


Ala Tyr Glu Lys Ser Phe Pro Ile Lys Pro Val Pro Ser Pro Ser Trp 
145                 150                 155                 160 


Ser Gly Ser Cys Arg Arg Ser Leu Leu Ser Pro Lys Lys Thr Gln Arg 
                165                 170                 175     


Arg His Val Ser Thr Ala Glu Glu Thr Val Gln Glu Glu Glu Arg Glu 
            180                 185                 190         


Ile Tyr Arg Gln Leu Leu Gln Met Val Thr Gly Lys Gln Phe Thr Ile 
        195                 200                 205             


Ala Lys Pro Thr Thr His Phe Pro Leu His Leu Ser Arg Cys Leu Ser 
    210                 215                 220                 


Ser Ser Lys Asn Thr Leu Lys Asp Ser Leu Phe Lys Asn Gly Asn Ser 
225                 230                 235                 240 


Cys Ala Ser Gln Ile Ile Gly Ser Asp Thr Ser Ser Ser Gly Ser Ala 
                245                 250                 255     


Ser Ile Leu Thr Asn Gln Glu Gln Leu Ser His Ser Val Tyr Ser Leu 
            260                 265                 270         


Ser Ser Tyr Thr Pro Asp Val Ala Phe Gly Ser Lys Asp Ser Gly Thr 
        275                 280                 285             


Leu His His Pro His His His His Ser Val Pro His Gln Pro Asp Asn 
    290                 295                 300                 


Leu Ala Ala Ser Asn Thr Gln Ser Glu Gly Ser Asp Ser Val Ile Leu 
305                 310                 315                 320 


Leu Lys Val Lys Asp Ser Gln Thr Pro Thr Pro Ser Ser Thr Phe Phe 
                325                 330                 335     


Gln Ala Glu Leu Trp Ile Lys Glu Leu Thr Ser Val Tyr Asp Ser Arg 
            340                 345                 350         


Ala Arg Glu Arg Leu Arg Gln Ile Glu Glu Gln Lys Ala Leu Ala Leu 
        355                 360                 365             


Gln Leu Gln Asn Gln Arg Leu Gln Glu Arg Glu His Ser Val His Asp 
    370                 375                 380                 


Ser Val Glu Leu His Leu Arg Val Pro Leu Glu Lys Glu Ile Pro Val 
385                 390                 395                 400 


Thr Val Val Gln Glu Thr Gln Lys Lys Gly His Lys Leu Thr Asp Ser 
                405                 410                 415     


Glu Asp Glu Phe Pro Glu Ile Thr Glu Glu Met Glu Lys Glu Ile Lys 
            420                 425                 430         


Asn Val Phe Arg Asn Gly Asn Gln Asp Glu Val Leu Ser Glu Ala Phe 
        435                 440                 445             


Arg Leu Thr Ile Thr Arg Lys Asp Ile Gln Thr Leu Asn His Leu Asn 
    450                 455                 460                 


Trp Leu Asn Asp Glu Ile Ile Asn Phe Tyr Met Asn Met Leu Met Glu 
465                 470                 475                 480 


Arg Ser Lys Glu Lys Gly Leu Pro Ser Val His Ala Phe Asn Thr Phe 
                485                 490                 495     


Phe Phe Thr Lys Leu Lys Thr Ala Gly Tyr Gln Ala Val Lys Arg Trp 
            500                 505                 510         


Thr Lys Lys Val Asp Val Phe Ser Val Asp Ile Leu Leu Val Pro Ile 
        515                 520                 525             


His Leu Gly Val His Trp Cys Leu Ala Val Val Asp Phe Arg Lys Lys 
    530                 535                 540                 


Asn Ile Thr Tyr Tyr Asp Ser Met Gly Gly Ile Asn Asn Glu Ala Cys 
545                 550                 555                 560 


Arg Ile Leu Leu Gln Tyr Leu Lys Gln Glu Ser Ile Asp Lys Lys Arg 
                565                 570                 575     


Lys Glu Phe Asp Thr Asn Gly Trp Gln Leu Phe Ser Lys Lys Ser Gln 
            580                 585                 590         


Glu Ile Pro Gln Gln Met Asn Gly Ser Asp Cys Gly Met Phe Ala Cys 
        595                 600                 605             


Lys Tyr Ala Asp Cys Ile Thr Lys Asp Arg Pro Ile Asn Phe Thr Gln 
    610                 615                 620                 


Gln His Met Pro Tyr Phe Arg Lys Arg Met Val Trp Glu Ile Leu His 
625                 630                 635                 640 


Arg Lys Leu Leu 
                


<210> 145
<211> 4948
<212> DNA
<213> Homo sapiens

<400> 145
atggagggag cctggtccag gagactgtgt cggacccggt cagccggccc gggctggact       60

gggcggaagc ggggagcact gtggggccgg cgccttttcc tctgccccgc cccctgggac      120

cacctcccct cccccctgct gtccggtggc cgcgctgtgg ccgccggtgg ccgttaggct      180

acctgaggcc gttccttctg gtctctctct cctgggccgc ggagagaccg tctccctgcc      240

gttacagcag gccccatccc agcgcccagc cgtacttggg gaaaggccgg ttgcgattcc      300

ggggctttcc cgccagagct gggtcttctc tggggagagc tgttttcacc gggaagctcg      360

gctttctgtg gtaccggctt catctcccgc cttccttgag acccgagtga tatttcttga      420

ctacttctgc gtctcacgta aacatttctc caactctcct actctgtggt atctccctga      480

gatgtgatat cgctagtgcc accatcagaa agaaacgtct ggaccctcct gctcaggact      540

ttgtatcttt gctaaagtca gtgatgtgaa aagacttgaa atggatgata ttgctgatag      600

gatgaggatg gatgctggag aagtgacttt agtgaaccac aactccgtat tcaaaaccca      660

cctcctgcca caaacaggtt ttccagagga ccagctttcg ctttctgacc agcagatttt      720

atcttccagg caaggacatt tggaccgatc ttttacatgt tccacaagaa gtgcagctta      780

taatccaagc tattactcag ataatccttc ctcagacagt tttcttggct caggcgattt      840

aagaaccttt ggccagagtg caaatggcca atggagaaat tctaccccat cgtcaagctc      900

atctttacaa aaatcaagaa acagccgaag tctttacctc gaaacccgaa agacctcaag      960

tggattatca aacagttttg cgggaaagtc aaaccatcac tgccatgtat ctgcatatga     1020

aaaatctttt cctattaaac ctgttccaag tccatcttgg agtggttcat gtcgtcgaag     1080

tcttttgagc cccaagaaaa ctcagaggcg acatgttagt acagcagaag agacagttca     1140

agaagaagaa agagagattt acagacagct gctacagatg gtcacaggga aacagtttac     1200

tatagccaaa cccaccacac attttccttt acacctgtct cgatgtctta gttccagtaa     1260

aaatactttg aaagactcac tgtttaaaaa tggaaactct tgtgcatctc agatcattgg     1320

ctctgatact tcatcatctg gatctgccag cattttaact aaccaggaac agctgtccca     1380

cagtgtatat tccctatctt cttatacccc agatgttgca tttggatcca aagattctgg     1440

tactcttcat catccccatc atcaccactc tgttccacat cagccagata acttagcagc     1500

ttcaaataca caatctgaag gatcagactc tgtgatttta ctgaaagtga aagattccca     1560

gactccaact cccagttcta ctttcttcca ggcagagctg tggatcaaag aattaactag     1620

tgtttatgat tctcgagcac gagaaagatt gcgccagatt gaagaacaga aggcattggc     1680

cttacagctt caaaaccaga gattgcagga gcgggaacat tcagtacatg attcagtaga     1740

actacatctt cgtgtacctc ttgaaaagga gattcctgtt actgttgtcc aagaaacaca     1800

aaaaaaaggt cataaattaa ctgatagtga agatgaattt cctgaaatta cagaggaaat     1860

ggagaaagaa ataaagaatg tatttcgtaa tgggaatcag gatgaagttc tcagtgaagc     1920

atttcgcctg accattacac gcaaagatat tcaaactcta aaccatctga attggctcaa     1980

tgatgagatc atcaatttct acatgaatat gctgatggag cgaagtaaag agaagggctt     2040

gccaagtgtg catgcattta ataccttttt cttcactaaa ttaaaaacgg ctggttatca     2100

ggcagtgaaa cgttggacaa agaaagtaga tgtattttct gttgacattc ttttggtgcc     2160

cattcacctg ggagtacact ggtgtctagc tgttgtggac tttagaaaga agaatattac     2220

ctattacgac tccatgggtg ggataaacaa tgaagcctgc agaatactct tgcaatacct     2280

aaagcaagaa agcattgaca agaaaaggaa agagtttgac accaatggct ggcagctttt     2340

cagcaagaaa agccaggaga ttcctcagca gatgaatgga agtgactgtg ggatgtttgc     2400

ctgcaaatat gctgactgta ttaccaaaga cagaccaatc aacttcacac agcaacacat     2460

gccatacttc cggaagcgga tggtctggga gatcctccac cgaaaactct tgtgaagact     2520

gtctcactta gcagaccttg accatgtggg ggaccagctc tttgttgtct acagccagag     2580

accttggaaa cagctgctcc cagccctctg ctgttgtaac acccttgatc ctggaccagg     2640

ccctggcgag atgcattcac aagcacatct gcctttcctt ttgtatctca gatactattt     2700

ttgcaaagaa actttggtgc tgtgaaaggg gtgagggaca tccctaagct gaagagagag     2760

actgcttttc acttcttcag ttctgccatc ttgttttcaa agggctccag cctcactcag     2820

tccctaatta tgggactgag aaaagcttgg aaagaatctt ggtttcatat aaattcttgt     2880

tgttaggcct tactaagaag taggaaaggg catgggcaaa aggtagggat aaaaaccacc     2940

agcatataca tggacataca cacacaccca cacacacaaa cacacacaca cacacaattt     3000

tcacgatgta tggtcaggaa tgtgactgta aactggactt tggggcccag gcataagtcc     3060

cttcctccag gacctttcct atttatatgt ccctatacaa aatccatctg cttttatacg     3120

tagctgtttt atcatctgta gcttcatcct atccggaggc acagcacatg agccctggac     3180

aggtcccaaa gttccaagca gtcctttccg tgaaagcagg ggtttgcatg tgctaccaac     3240

acatgatacg gggaagaccc acccagggag cggtttcagt ggcgcaacaa agcaccactt     3300

ttactgttgc ctacttctga ccaagaagaa aaaggacctt agtatttagc ataaaattcc     3360

agcgctggat gaatgcagat ctagtttggt ctgtggctag tttaaatatg tttctaacca     3420

cagagaattt catatatata tacatatata tatacacata catatatata tatatatatg     3480

tatgtataaa atttcacagg gatatgcttt tttttttaaa gactgaatgt gttcaccatt     3540

tagcctgtag atttatttcc attttccaaa ttccagcaca cagagatccc agcccctatg     3600

agtagggtgt ttgtggacta cctaatggaa tatttttgag gcctggatga actttgccat     3660

atgggtagag gttacagagg gaggtgatat tttcagctaa aaaaaaaaac gggtggagtt     3720

tggactgatc aacttgagat ttaaaaactg ctattccttt tgttctttct agcatctctc     3780

cccaccctct gagagctcct caggcttaga tagtgaagtg atcaaatgcc agtgtcattt     3840

tgtacttaag ttccaaagta ggaacatttt atactttttt ctgtattgta ataggtagtt     3900

ttgtatgaaa tcttttctcc tctcccgttg taccgcattc tttccagcat tgtgcttttt     3960

ccctgggctt atttgaaaat tttactgttt tatacaagct cgtttagtac atttttctat     4020

gttttaccac aagttacaat ttgaaaagaa aactattttt tttaaatatt ccattgttaa     4080

ctgaatgtta ctgtttccac tccagcaact acatgtcctc ccttcaactg cctgcctttt     4140

ggggaaagac caccttttgt gtgtttgttt tttctctctc tttctttccc tttctctttc     4200

tatctctctt tatttttctt tctttttctt tgtttttgag ttttctatag gaaataaata     4260

gctttctata tatgagttgc tggggacctt cacattctct tttagaaagc tgtggcatgc     4320

agtctcattg caggactcct ggaatattgt ctggttcttg gtatttactg tatgtaagca     4380

acaacttgaa aggtggcaat atggtgtcga tttggactat gaatcaaaag acctttttca     4440

ggttctttca ctattgtctg ggggactcag aacaagattg ttctctgtat ttattgtttg     4500

tccatttagg taacatctgt cttaccttcc tcacagactt tgtacagacc aaagcaacaa     4560

atatttattg ccatgtatag cagaaaatga aacatgcaac aaaagcactt tgaaaaatat     4620

ataaggaatt gttgagcctg tctgaatttg ggcccccttt ctgactaatg cagttttgca     4680

caaggtagaa gttagtgacc ctgagaccat cttaccaccc tggacctggt ccaaatacag     4740

acttacacag tggaccattc tttcctgagc tagccaacaa gagcaggagt agtatctgga     4800

aactttcccc tttgtttagg ggtaggcttt gatgaccagg aaaaaaaaaa aggtatttct     4860

gcattttatg gcccaaaggc atgttattaa tatcttatgt aatttacttt aaactaaata     4920

agactttttt ctcctgtgta aaaaaaaa                                        4948


<210> 146
<211> 644
<212> PRT
<213> Homo sapiens

<400> 146
Met Asp Asp Ile Ala Asp Arg Met Arg Met Asp Ala Gly Glu Val Thr 
1               5                   10                  15      


Leu Val Asn His Asn Ser Val Phe Lys Thr His Leu Leu Pro Gln Thr 
            20                  25                  30          


Gly Phe Pro Glu Asp Gln Leu Ser Leu Ser Asp Gln Gln Ile Leu Ser 
        35                  40                  45              


Ser Arg Gln Gly His Leu Asp Arg Ser Phe Thr Cys Ser Thr Arg Ser 
    50                  55                  60                  


Ala Ala Tyr Asn Pro Ser Tyr Tyr Ser Asp Asn Pro Ser Ser Asp Ser 
65                  70                  75                  80  


Phe Leu Gly Ser Gly Asp Leu Arg Thr Phe Gly Gln Ser Ala Asn Gly 
                85                  90                  95      


Gln Trp Arg Asn Ser Thr Pro Ser Ser Ser Ser Ser Leu Gln Lys Ser 
            100                 105                 110         


Arg Asn Ser Arg Ser Leu Tyr Leu Glu Thr Arg Lys Thr Ser Ser Gly 
        115                 120                 125             


Leu Ser Asn Ser Phe Ala Gly Lys Ser Asn His His Cys His Val Ser 
    130                 135                 140                 


Ala Tyr Glu Lys Ser Phe Pro Ile Lys Pro Val Pro Ser Pro Ser Trp 
145                 150                 155                 160 


Ser Gly Ser Cys Arg Arg Ser Leu Leu Ser Pro Lys Lys Thr Gln Arg 
                165                 170                 175     


Arg His Val Ser Thr Ala Glu Glu Thr Val Gln Glu Glu Glu Arg Glu 
            180                 185                 190         


Ile Tyr Arg Gln Leu Leu Gln Met Val Thr Gly Lys Gln Phe Thr Ile 
        195                 200                 205             


Ala Lys Pro Thr Thr His Phe Pro Leu His Leu Ser Arg Cys Leu Ser 
    210                 215                 220                 


Ser Ser Lys Asn Thr Leu Lys Asp Ser Leu Phe Lys Asn Gly Asn Ser 
225                 230                 235                 240 


Cys Ala Ser Gln Ile Ile Gly Ser Asp Thr Ser Ser Ser Gly Ser Ala 
                245                 250                 255     


Ser Ile Leu Thr Asn Gln Glu Gln Leu Ser His Ser Val Tyr Ser Leu 
            260                 265                 270         


Ser Ser Tyr Thr Pro Asp Val Ala Phe Gly Ser Lys Asp Ser Gly Thr 
        275                 280                 285             


Leu His His Pro His His His His Ser Val Pro His Gln Pro Asp Asn 
    290                 295                 300                 


Leu Ala Ala Ser Asn Thr Gln Ser Glu Gly Ser Asp Ser Val Ile Leu 
305                 310                 315                 320 


Leu Lys Val Lys Asp Ser Gln Thr Pro Thr Pro Ser Ser Thr Phe Phe 
                325                 330                 335     


Gln Ala Glu Leu Trp Ile Lys Glu Leu Thr Ser Val Tyr Asp Ser Arg 
            340                 345                 350         


Ala Arg Glu Arg Leu Arg Gln Ile Glu Glu Gln Lys Ala Leu Ala Leu 
        355                 360                 365             


Gln Leu Gln Asn Gln Arg Leu Gln Glu Arg Glu His Ser Val His Asp 
    370                 375                 380                 


Ser Val Glu Leu His Leu Arg Val Pro Leu Glu Lys Glu Ile Pro Val 
385                 390                 395                 400 


Thr Val Val Gln Glu Thr Gln Lys Lys Gly His Lys Leu Thr Asp Ser 
                405                 410                 415     


Glu Asp Glu Phe Pro Glu Ile Thr Glu Glu Met Glu Lys Glu Ile Lys 
            420                 425                 430         


Asn Val Phe Arg Asn Gly Asn Gln Asp Glu Val Leu Ser Glu Ala Phe 
        435                 440                 445             


Arg Leu Thr Ile Thr Arg Lys Asp Ile Gln Thr Leu Asn His Leu Asn 
    450                 455                 460                 


Trp Leu Asn Asp Glu Ile Ile Asn Phe Tyr Met Asn Met Leu Met Glu 
465                 470                 475                 480 


Arg Ser Lys Glu Lys Gly Leu Pro Ser Val His Ala Phe Asn Thr Phe 
                485                 490                 495     


Phe Phe Thr Lys Leu Lys Thr Ala Gly Tyr Gln Ala Val Lys Arg Trp 
            500                 505                 510         


Thr Lys Lys Val Asp Val Phe Ser Val Asp Ile Leu Leu Val Pro Ile 
        515                 520                 525             


His Leu Gly Val His Trp Cys Leu Ala Val Val Asp Phe Arg Lys Lys 
    530                 535                 540                 


Asn Ile Thr Tyr Tyr Asp Ser Met Gly Gly Ile Asn Asn Glu Ala Cys 
545                 550                 555                 560 


Arg Ile Leu Leu Gln Tyr Leu Lys Gln Glu Ser Ile Asp Lys Lys Arg 
                565                 570                 575     


Lys Glu Phe Asp Thr Asn Gly Trp Gln Leu Phe Ser Lys Lys Ser Gln 
            580                 585                 590         


Glu Ile Pro Gln Gln Met Asn Gly Ser Asp Cys Gly Met Phe Ala Cys 
        595                 600                 605             


Lys Tyr Ala Asp Cys Ile Thr Lys Asp Arg Pro Ile Asn Phe Thr Gln 
    610                 615                 620                 


Gln His Met Pro Tyr Phe Arg Lys Arg Met Val Trp Glu Ile Leu His 
625                 630                 635                 640 


Arg Lys Leu Leu 
                


<210> 147
<211> 560
<212> DNA
<213> Homo sapiens

<400> 147
gaccagattg ggtgcttggc cgtccctgcc attagcgcgt aacgagagac tgcttgctgc       60

ggcagagacg ccagaggtgc agctccagca gcaatggcag tgacggcgtt ggcggcgcgg      120

acgtggcttg gcgtgtgggg cgtgaggacc atgcaagccc gaggcttcgg ctcggatcag      180

tccgagaatg tcgaccgggg cgcgggctcc atccgggaag ccggtggggc cttcggaaag      240

agagagcagg ctgaagagga acgatatttc cgagcacaga gtagagaaca actggcagct      300

ttgaaaaaac accatgaaga agaaatcgtt catcataaga aggagattga gcgtctgcag      360

aaagaaattg agcgccataa gcagaagatc aaaatgctaa aacatgatga ttaagtgcac      420

accgtgtgcc atagaatggc acatgtcatt gcccacttct gtgtagacat ggttctggtt      480

taactaatat ttgtctgtgt gctactaaca gattataata aattgtcatc agtgaactgt      540

gaaaaaaaaa aaaaaaaaaa                                                  560


<210> 148
<211> 106
<212> PRT
<213> Homo sapiens

<400> 148
Met Ala Val Thr Ala Leu Ala Ala Arg Thr Trp Leu Gly Val Trp Gly 
1               5                   10                  15      


Val Arg Thr Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
            20                  25                  30          


Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
        35                  40                  45              


Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg Ala Gln Ser Arg 
    50                  55                  60                  


Glu Gln Leu Ala Ala Leu Lys Lys His His Glu Glu Glu Ile Val His 
65                  70                  75                  80  


His Lys Lys Glu Ile Glu Arg Leu Gln Lys Glu Ile Glu Arg His Lys 
                85                  90                  95      


Gln Lys Ile Lys Met Leu Lys His Asp Asp 
            100                 105     


<210> 149
<211> 636
<212> DNA
<213> Homo sapiens

<400> 149
gaccagattg ggtgcttggc cgtccctgcc attagcgcgt aacgagagac tgcttgctgc       60

ggcagagacg ccagaggtgc agctccagca gcaatggcag tgacggcgtt ggcggcgcgg      120

acgtggcttg gcgtgtgggg cgtgaggacc atgcaagccc gaggcttcgg ctcggatcag      180

tccgagaatg tcgaccgggg cgcgggctcc atccgggaag ccggtggggc cttcggaaag      240

agagagcagg ctgaagagga acgatatttc cgacattaca ggttatgctt tgagatctct      300

ttggggtgaa ggattgaaat taaaccctga gccaccgtgt ccttgtagag cacagagtag      360

agaacaactg gcagctttga aaaaacacca tgaagaagaa atcgttcatc ataagaagga      420

gattgagcgt ctgcagaaag aaattgagcg ccataagcag aagatcaaaa tgctaaaaca      480

tgatgattaa gtgcacaccg tgtgccatag aatggcacat gtcattgccc acttctgtgt      540

agacatggtt ctggtttaac taatatttgt ctgtgtgcta ctaacagatt ataataaatt      600

gtcatcagtg aactgtgaaa aaaaaaaaaa aaaaaa                                636


<210> 150
<211> 71
<212> PRT
<213> Homo sapiens

<400> 150
Met Ala Val Thr Ala Leu Ala Ala Arg Thr Trp Leu Gly Val Trp Gly 
1               5                   10                  15      


Val Arg Thr Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
            20                  25                  30          


Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
        35                  40                  45              


Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg His Tyr Arg Leu 
    50                  55                  60                  


Cys Phe Glu Ile Ser Leu Gly 
65                  70      


<210> 151
<211> 1944
<212> DNA
<213> Homo sapiens

<400> 151
gaccagattg ggtgcttggc cgtccctgcc attagcgcgt aacgagagac tgcttgctgc       60

ggcagagacg ccagaggtgc agctccagca gcaatggcag tgacggcgtt ggcggcgcgg      120

acgtggcttg gcgtgtgggg cgtgaggacc atgcaagccc gaggcttcgg ctcggatcag      180

tccgagaatg tcgaccgggg cgcgggctcc atccgggaag ccggtggggc cttcggaaag      240

agagagcagg ctgaagagga acgatatttc cggtgaggct caccgggtcc caagtccagc      300

cctggatctc ccaatggcct tccaatcctt aaactgccaa tcgccccacc cgttcctacc      360

tggtgccttg ggcgccccat cccccaacag aactcccggg ccccaatcca gtatacccta      420

acccttgatg tcccgaccgt tgccacgtat agggcactcc cagttacctg cacaacagtt      480

tcaggccccc aaaccgtttc caccggcggg tctccaaaac aacccacggc tcaactcctc      540

ctttatcatt accatctccc gcgtggagtt ctcctcaggt cgtgcgaaac acccccagat      600

tcttcgcaca gtgtctagat ccgaccgccc aacgtttgcc tcccagcctg actccctcgg      660

cccttaccca cctgtcaccc cctctacgct ctccttcctc gccagcacgc cttagctttg      720

caagcctgca tgcattcagg cttctcaggt gtttctagac ccccgactcc gcaagagtga      780

ggatgatggg agctggtcat gggagctact tatggttgga caccatcttc taaaggcttt      840

tgccctactc agcccaacct agacctgtag atttccctct cctgcttagg agtatggagt      900

gggctgggcc tccctttgcc agccttgagt tatctttaac tgacttctgt ccactctgga      960

gagcagtgag gaattaatct tgcttttgct tgtcctttgg cctttcactt ctgccttctg     1020

ttgagaatta tcaccatgac acctgccata ccgtatagag agccaaggta cagccgttag     1080

agactatcta attgagcccc tacattttgt agttaaggaa aactgaggcc taaatgtgac     1140

caaaccaaca ttgtaatcca gtcccttctt ggaacctaaa ttgaactgcc aagtactgcg     1200

catgcaagag accctttatt ggccttacag tgggccattc atttctatag gcaaagaaag     1260

ctctagacag attggaatag gaaatggata tttgcctttt agctacaccc ctttgtctgt     1320

cttcctcatt ttgttccttt ttttttccct aaaggggagt caagttccct gggttgttcc     1380

cctcataagg tattagggac ttgtgtcaca tctctctgga gttttctatt ttaaagagga     1440

atctgaaagc aataagctct ttggtcttct taagatggct acacctcaat ttaagatggg     1500

gtattctttc actagttgag gagtagaaga ggatgaccag ctagactccc atggaattgg     1560

aactcctatt ccttgcttag acattacagg ttatgctttg agatctcttt ggggtgaagg     1620

attgaaatta aaccctgagc caccgtgtcc ttgtagagca cagagtagag aacaactggc     1680

agctttgaaa aaacaccatg aagaagaaat cgttcatcat aagaaggaga ttgagcgtct     1740

gcagaaagaa attgagcgcc ataagcagaa gatcaaaatg ctaaaacatg atgattaagt     1800

gcacaccgtg tgccatagaa tggcacatgt cattgcccac ttctgtgtag acatggttct     1860

ggtttaacta atatttgtct gtgtgctact aacagattat aataaattgt catcagtgaa     1920

ctgtgaaaaa aaaaaaaaaa aaaa                                            1944


<210> 152
<211> 60
<212> PRT
<213> Homo sapiens

<400> 152
Met Ala Val Thr Ala Leu Ala Ala Arg Thr Trp Leu Gly Val Trp Gly 
1               5                   10                  15      


Val Arg Thr Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
            20                  25                  30          


Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
        35                  40                  45              


Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg 
    50                  55                  60  


<210> 153
<211> 2225
<212> DNA
<213> Homo sapiens

<400> 153
agtgacgtct ttgccccgcg ccgcgccgtc ccacccatct ccctggcctc cggtcccaac       60

ttcgcttctc tgctgaccct ctctcgtcgc cgctgccgcc gccgcagctg ccaaaatgtc      120

tacaggtcca actgctgcca ctggcagtaa tcgaagactt cagcagacac aaaatcaagt      180

agatgaggtg gtggacataa tgcgagttaa cgtggacaag gttctggaaa gagaccagaa      240

gctctctgag ttagacgacc gtgcagacgc actgcaggca ggcgcttctc aatttgaaac      300

gagcgcagcc aagttgaaga ggaaatattg gtggaagaat tgcaagatgt gggcaatcgg      360

gattactgtt ctggttatct tcatcatcat catcatcgtg tgggttgtct cttcatgaag      420

aaccagcgga actcaaaact gctgttcaag aaacctcttc aagacttttg acttagaacc      480

tgctatatta tcaagcttac ctactgttat ctctaaaatt ttttttgtgt taatgtaaag      540

ttgaatttct aggaaacgtg cctttgtttt ttaatatgca ctccaaatta gaaggccggc      600

cccgtccaca ttttgcacag tgcctttaca gatttacgta tgggctgatg aagaggcctt      660

cttaagttcc agagtgctat aatctagatg taatgttgtc actaattaat tgccattact      720

cccagttagt tacccttgtc atttggcatt attttcagaa ccacatttta aacctttggg      780

taatcagatt tccaacttat gccttccaga aaaaaacact actgcctaac acaaatctgt      840

gataacaaca ggctgtgcct tattttgata attttctgat tccctagaag agaaccctct      900

actttttgta agcactactg actctcgctg tatttaagat gctggtgaag agcttttgct      960

cttgcattag atttgaagat gtttacattg ttgttattgt tatgtatcac ttgctaaaaa     1020

tattgtttta atcagagata acctctttaa aaaaattttt aaagaactat ggctatgacc     1080

aaagcttcta ttttgccaaa aagttaaata ccgataaaat ggccttaagt gtattcctga     1140

cagttaaatt cagaaacgtg ccaaatggaa ctcaaggtgc cccttcagaa ttaaaatcat     1200

taccttgtgt gtgaaccttc tacatcttca taggcctttc ttccttttga aaggctgtag     1260

acagtgtggc tccccttctg attcagtatt ttgcatgggg gttagagaag gtttgaggta     1320

gactctgacc gtctcataaa agagttctac ccagcagttg gcagattatc agctgtggac     1380

tccagcatgt ttctgataat tatgcaagca acaattctgt agcctcaagt aagaccacct     1440

gtgaacttga tcattatctg gcccaaatat gaagataaac tataactttg gagtttgttt     1500

cctatttgta ttcacattct gcttcctaaa tcagttttct aaattatgcc tgcaattagg     1560

cattggtcag gggtgaatgg ctcttttcac agagagtagc caaccagaga cctttgcttt     1620

gatatcatca actgcagaga atgctgttga tgggaatgct ggaagcagaa actttgtcat     1680

cggaaaaact tttcttgtat gcatgagact caacatcagg atccacagct taaagatggg     1740

aattcaggta tgaaagaaaa caggcaagga ggcactgagg gagaaagaca cagactttat     1800

cgctctgtgg ctcattgtta ctggaatatt ctaaaactct tgttcacatg ctattatgac     1860

ttataaagca gcaacagctg aggcgcacca ggacacagct tccatttctt taacgtctgt     1920

tcccttaaca tcgctgaaat gatttactgt tgaagagatg ccttgcggtg tggccagctg     1980

tgaggagaaa gcagctggca gtgttaggac attagtccac cttcagcgca gggtctctgg     2040

ccgggtctga ctcagaaacc ttggtactcg ccccttggcc acagtgccca gacccatgta     2100

acccactggc tcctgcatta acccagaaat acctcgcttc tatctgtgca cttagctggg     2160

aacttaccca ctgtaatcac ctaaataaag tgtttataaa catgaaaaaa aaaaaaaaaa     2220

aaaaa                                                                 2225


<210> 154
<211> 100
<212> PRT
<213> Homo sapiens

<400> 154
Met Ser Thr Gly Pro Thr Ala Ala Thr Gly Ser Asn Arg Arg Leu Gln 
1               5                   10                  15      


Gln Thr Gln Asn Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
            20                  25                  30          


Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
        35                  40                  45              


Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
    50                  55                  60                  


Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys Met Trp Ala 
65                  70                  75                  80  


Ile Gly Ile Thr Val Leu Val Ile Phe Ile Ile Ile Ile Ile Val Trp 
                85                  90                  95      


Val Val Ser Ser 
            100 


<210> 155
<211> 6994
<212> DNA
<213> Homo sapiens

<400> 155
agaagctccc ggccgggggc gcgcacgtag gcacgcagag gccgtcacgt gggtcgccga       60

ggctcgcaag tgcgcgtggc cgtggcggct ggtgtggggt tgagtcagtt gtgggacccg      120

gagctgctga cccagcgggt ggcccaccga accggtgaca cagcggcagg cgttagggct      180

cgggagccgc gagcctggcc tcgtcctaga gctcggccga gccgtcgccg ccgtcgtccc      240

ccgcccccag tcagcaaacc gccgccgcgg gcgcgccccc gctctgcgct gtctctccga      300

tggcgtccgc ctcaggggcc atggcgaagc acgagcagat cctggtcctc gatccgccca      360

cagacctcaa attcaaaggc cccttcacag atgtagtcac tacaaatctt aaattgcgaa      420

atccatcgga tagaaaagtg tgtttcaaag tgaagactac agcacctcgc cggtactgtg      480

tgaggcccaa cagtggaatt attgacccag ggtcaactgt gactgtttca gtaatgctac      540

agccctttga ctatgatccg aatgaaaaga gtaaacacaa gtttatggta cagacaattt      600

ttgctccacc aaacacttca gatatggaag ctgtgtggaa agaggcaaaa cctgatgaat      660

taatggattc caaattgaga tgcgtatttg aaatgcccaa tgaaaatgat aaattgggta      720

taactccacc agggaatgct ccgactgtca cttcaatgag cagcatcaac aacacagttg      780

caacacctgc cagttatcac acgaaggatg accccagggg actcagtgtg ttgaaacagg      840

agaaacagaa gaatgatatg gaacctagca aagctgttcc actgaatgca tctaagcaag      900

atggacctat gccaaaacca cacagtgttt cacttaatga taccgaaaca aggaaactaa      960

tggaagagtg taaaagactt cagggagaaa tgatgaagct atcagaagaa aatcggcacc     1020

tgagagatga aggtttaagg ctcagaaagg tagcacattc ggataaacct ggatcaacct     1080

caactgcatc cttcagagat aatgtcacca gtcctcttcc ttcacttctt gttgtaattg     1140

cagccatttt cattggattc tttctaggga aattcatctt gtagagtgaa gcatgcagag     1200

tgctgtttct tttttttttt ttctcttgac cagaaaaaga tttgtttacc taccatttca     1260

ttggtagtat ggcccacggt gaccattttt ttgtgtgtac agcgtcatat aggctttgcc     1320

tttaatgatc tcttacggtt agaaaacaca ataaaaacaa actgttcggc tactggacag     1380

gttgtatatt accagatcat cactagcaga tgtcagttgc acattgagtc ctttatgaaa     1440

ttcataaata aagaattgtt ctttctttgt ggttttaata agagttcaag aattgttcag     1500

agtcttgtaa atgttatttt aataatccct ttaaatttta tctgttgctg ttacctcttg     1560

aaatatgatt tatttagatt gctaatccca ctcattcagg aaatgccaag aggtattcct     1620

tggggaaatg gtgcctctta cagtgtaaat ttttcctcct ttacctttgc taatatcatg     1680

gcagaatttt tcttatccct tgtgaggcag ttgttgactg agtttttcat ccttacaatc     1740

ctgtcccatg gtatttaaca taaaaaaaaa taaaactgtt aacagattct tgctcgatag     1800

cttgtttgtg tctgtcgtgt tattagaggg aactccacta tatatggtca cttgaaatta     1860

tgatgcaaag gtttctcttg cattgaaacc ctcttggata ttacagtatt tttaattgaa     1920

agtcctaatt ctgttaagga aaggagttga ttaaatttta aggtaccact ggtattttgg     1980

gagattataa tcagtttgtt ttcaagataa tagaaaataa ggtccatgag aatagaagtt     2040

atgtgatttc agtgagttga tgtgtacagc atggctgtgc tccatctgat ttaccccatt     2100

cttaagttct gagagtatgt tctcaaggaa gatttaactc tctttggttt taaattactt     2160

tttaaccagc ctaataaata agtcttacta cttttcataa tatttcataa tagttaaaag     2220

taggtgtttt tttcgtgctc aatttggcac tcaaaataat gttcattatg gaagtttggt     2280

aatactgagc aagcctgtgg aattttcttt atgaaaaatg attttagcct ttgcaaatgt     2340

taaccatgtg aaacacattt tcagtataag tatgcgttac agggtttgat actttcctgc     2400

acttaggttt gtcctattct tcatttattc atactaggat agaaaatttt ggaatcagaa     2460

aatagatcca gtgtttagct acatacaatc tagtacaagt gaatttttat tcttaaacat     2520

aggtgtgttg gctctttttt taaaagatgc gctctacctg aaaaggaaat tggattttag     2580

aactggatgt ggtgcagtga agtattttag gcccaggtct gtgtacacat tttatagaag     2640

aatgaagtac tctgaagtat tttggttgcc ttttcatttc aactgtgttt tgaatttgtc     2700

agatcacaca tatattgtgt tattgggcgc tgtggtatct tttataaaac ctcttgcttg     2760

tgtgcaaaag ttcctaaaag gaaacacaag taatgcctat ccattactag catgctatgc     2820

tgcatgcttt actgccattg ctgtatgctt tactgtcttt gtaaaaatcc ccctctcccc     2880

ttttctggta actggaaaag catgctaaaa atagtcttat attttcaccc cataaatgca     2940

gaatcagtaa ttccttggct taaagctctt atataatcaa tattattggt ggtaaatacc     3000

aagtttggta tctcatagct atcttttttt aaagaaatta agttcttgaa aatttagcca     3060

aatcccgttt tatgggaatg ctctttagaa ttcattttgt tcagcccctt tgttctatgg     3120

ttgagaaatc tgaggcctta cgaaggttaa gagaactttc cccgtgtctc acaggtaggt     3180

agaggcagag ctggaactag atatctggtc tgttgactct agctcagtgt cttctggtaa     3240

ctgttgaaaa ttgtcttagt ttgagagatg gctgaaataa tgaacataaa atgctattta     3300

taataacaag tatatgtgaa atttcttatt gtaagactac taccggctta ctgttgaata     3360

gtttggttat agtgtttagg ctagaaatgc ctcccacatt ggtaataaac attacaaaat     3420

acaatgtatt tttaggtagg cattttataa aatgcattat gccatggttg cttttgagat     3480

agattgtagt ctgggtagca tctttaaaat gtatgtgggc ttaactgttg ttcatatcag     3540

gagatgctct gattgtatag gtgagactct gtttctgtta tttttaattg ctgtatgaaa     3600

tgtgatcaga ttattttact accaacagtt atagtttgaa agtccaactg tattaattga     3660

ctgataatat gataatatag agattaaatt gtttgtcttc attccttata tgtttagaag     3720

tttttgcttt gtctgcctgc ttacttgtat atgtaagcat gagggaaata cactgttgct     3780

aatactgaaa ttacaatcaa gtaactaagg ccttgagttc atatgtgaca ctgaatgcac     3840

tagcttcctt cgttctataa ctaatgtacc ttaacttccc ccattcttat atttacaaga     3900

agctaagtca ttatgttctg agtgtgtggt atgttccctt aaaaaaaaat gacacttgga     3960

agaaaaatgt atgaaattca gaaattccga tcaaagaaaa gtaattcttt cttttttttt     4020

ttgagacaga gtcttgcttt gttgcccagg ctggagggca gtggtgtgat ctcacctcac     4080

tgcagcttcc gcctcctggg ttcaagtgat tctcatggct cagccgcctg agtagctggg     4140

attacaggtg tgagccaaca agcccggcta atttttgtat ttttagtaga gacaaggttt     4200

caccatgttg gtcaggctgg gctcaaactc ctgaatccgc ctgcctcggc ctcccaaagt     4260

gctgggatta caggtgtgag ctgccgcacc cagccaagaa aaataatact cttaaatact     4320

tagatgttca cctaaagttg atattatttg gtatgggaat tacttttgaa ctgtaatctt     4380

tcagattaca ccactttgaa aacaagtttt aacagtaggg taaaaatata gtttttgagg     4440

gtattcccaa cttgtgatct tctaccactt tagagacatt caagtaatag ttttcttaga     4500

gctttgcaca ttcctattca ctgagatttt aaaaatttca cctttattcg agggaaggat     4560

caatgcttat taccatttgg aaaaacgaag atcagaaggt aaatgatctt tattttctag     4620

ctttaaaggg aaattaaacc attcatgaat aaactttaaa aatgtgaagt gtccttttcc     4680

ttttcacaat acaaaaaaaa tttcaacaga ttgtgtggtt tgtgcattta tatcctgtta     4740

agcattaata gctaatcact gggacttgaa ttctgatggc agatagtctc ttgcttagtg     4800

agatggagtt aactattttt tagtaggaag tgagaacagc tgattttcat gccacgtttc     4860

atagccccac ttttggtaga ctaccaccac gcttcttcgc gtaagcagtg gcatcttggg     4920

aatgaatgcc cagccgctcg tgggttggtg caaagaagta taaacatata tcactaagga     4980

aaaagaaagt ttgtcttgcc cttctgacac agtgtgtgca cttcaggcaa tttttggaaa     5040

atataaaaaa ttccaaattc tgcctttcag cagcatcaat tgctaggaac atttcattca     5100

tttccctgta atattaatgt tctttaagca taatcactaa ttataagttg tatcctattt     5160

ttttccagct taatttctgt ggtttattga aaaccaagta taaatgtgac taaaagcatt     5220

ttgctttgtt tttatagtta actttcttaa ggttatggac attttataat gtaacatttg     5280

attggcctgg cctcttgaca attcccttct agttatgcat atcctcctgt tgccacattt     5340

cttgttttaa aactcagttt cttgttttcc agttgttgct atgtataaca cccatcttga     5400

aagagagtat ataggaagtt attcagataa cttttgtagt agtgatattc aactatagca     5460

gtaccttaac tcatgatgag cttaggaaca taaaagataa ttgttgcttg aatagcaccc     5520

ccagagatac tgacctaatt ggtctggggt ggagatctgg catggtagtt tttttcaagc     5580

tccaatcatc ggccagacag ttgctttatg taggttttta aatgccaaag gcagatatga     5640

agtagattta attaagactt gacttcagca atacagggga acttaaaata cttatttttc     5700

tttaaactgc aggagtcact gttaggtatt gcttaaaaaa aattgcataa aagctttgct     5760

tgtcaagtta ggattgctgg aataccacta aagatttttg acttgtgaat aaatgagctg     5820

tcatcgcaaa aaggcgattt gagaaatgtg ggcttcagta ttaattgcca ttttgctgac     5880

acccagtgta cctacctacc tgagaaattt attttgtcca tcatgtattt ctcaaagcaa     5940

aaggtggttt tcaagtataa tgtcgttttc aacatgctta ttacttagtt ttacgtcagc     6000

tcatttcatc atcattgata acttgtgaaa tacttatctc catcctatgg aataggggag     6060

acgggtttag acaggttcaa ttagctcaag tctacacagc tgaagtagca gagaaagtgg     6120

gatctagatg gtctgatcct agtgatctac catatgaagg acatagtttg tgtcctggtc     6180

caagtcaaat attgactcct cacaaacagt aagtatggca attttgtgat gcctttgatt     6240

ccactttaca tggagtacta ttatttgtga aatgtcttta agatttttgg tcttaaattt     6300

ttgaagactg ctttccccct ttatctccca gaaaattgag aagaagtaaa ctcctgccca     6360

ctaacaatct cagtccgtga acaaaaccaa catgaacatt cctaaacaag agtgtgtgtt     6420

actctaagaa gaaggctata gaatttatgg aaatggctta tgtaacctac aagactggag     6480

aacagaatgt gactggcctt ttctaatggt cctttaagat ttaatgatta aagcaagagt     6540

tttttataat tgactttgtg gtctaaattc ttgatactgt ttataattct acaaagaaca     6600

aaaattgtta tgtactatag gcacttaaga accctgagga aaaataatac aatgtgtgtg     6660

tgtgagagag agagtgagtt actgacattg ttccaaaaaa aaaaaaaaaa aaaaaaaaaa     6720

tgtggagggt tgaaatggta aggaattgga atcttttgta ttttcgagca ataagaattc     6780

ctattcttgt ttcaaataga ggtttgttag gaattacagt tgtggggagc aaactttctt     6840

ttttgtgctg ttttaattca aaatgtatat ccttaattgt atataatatg tagataaata     6900

tatgagggta ttaagctact ttgaattaaa tttaaggata tatttcacat gaaaacaaat     6960

acaaacgaga atcaaaataa agttttgcaa agta                                 6994


<210> 156
<211> 294
<212> PRT
<213> Homo sapiens

<400> 156
Met Ala Ser Ala Ser Gly Ala Met Ala Lys His Glu Gln Ile Leu Val 
1               5                   10                  15      


Leu Asp Pro Pro Thr Asp Leu Lys Phe Lys Gly Pro Phe Thr Asp Val 
            20                  25                  30          


Val Thr Thr Asn Leu Lys Leu Arg Asn Pro Ser Asp Arg Lys Val Cys 
        35                  40                  45              


Phe Lys Val Lys Thr Thr Ala Pro Arg Arg Tyr Cys Val Arg Pro Asn 
    50                  55                  60                  


Ser Gly Ile Ile Asp Pro Gly Ser Thr Val Thr Val Ser Val Met Leu 
65                  70                  75                  80  


Gln Pro Phe Asp Tyr Asp Pro Asn Glu Lys Ser Lys His Lys Phe Met 
                85                  90                  95      


Val Gln Thr Ile Phe Ala Pro Pro Asn Thr Ser Asp Met Glu Ala Val 
            100                 105                 110         


Trp Lys Glu Ala Lys Pro Asp Glu Leu Met Asp Ser Lys Leu Arg Cys 
        115                 120                 125             


Val Phe Glu Met Pro Asn Glu Asn Asp Lys Leu Gly Ile Thr Pro Pro 
    130                 135                 140                 


Gly Asn Ala Pro Thr Val Thr Ser Met Ser Ser Ile Asn Asn Thr Val 
145                 150                 155                 160 


Ala Thr Pro Ala Ser Tyr His Thr Lys Asp Asp Pro Arg Gly Leu Ser 
                165                 170                 175     


Val Leu Lys Gln Glu Lys Gln Lys Asn Asp Met Glu Pro Ser Lys Ala 
            180                 185                 190         


Val Pro Leu Asn Ala Ser Lys Gln Asp Gly Pro Met Pro Lys Pro His 
        195                 200                 205             


Ser Val Ser Leu Asn Asp Thr Glu Thr Arg Lys Leu Met Glu Glu Cys 
    210                 215                 220                 


Lys Arg Leu Gln Gly Glu Met Met Lys Leu Ser Glu Glu Asn Arg His 
225                 230                 235                 240 


Leu Arg Asp Glu Gly Leu Arg Leu Arg Lys Val Ala His Ser Asp Lys 
                245                 250                 255     


Pro Gly Ser Thr Ser Thr Ala Ser Phe Arg Asp Asn Val Thr Ser Pro 
            260                 265                 270         


Leu Pro Ser Leu Leu Val Val Ile Ala Ala Ile Phe Ile Gly Phe Phe 
        275                 280                 285             


Leu Gly Lys Phe Ile Leu 
    290                 


<210> 157
<211> 6859
<212> DNA
<213> Homo sapiens

<400> 157
agaagctccc ggccgggggc gcgcacgtag gcacgcagag gccgtcacgt gggtcgccga       60

ggctcgcaag tgcgcgtggc cgtggcggct ggtgtggggt tgagtcagtt gtgggacccg      120

gagctgctga cccagcgggt ggcccaccga accggtgaca cagcggcagg cgttagggct      180

cgggagccgc gagcctggcc tcgtcctaga gctcggccga gccgtcgccg ccgtcgtccc      240

ccgcccccag tcagcaaacc gccgccgcgg gcgcgccccc gctctgcgct gtctctccga      300

tggcgtccgc ctcaggggcc atggcgaagc acgagcagat cctggtcctc gatccgccca      360

cagacctcaa attcaaaggc cccttcacag atgtagtcac tacaaatctt aaattgcgaa      420

atccatcgga tagaaaagtg tgtttcaaag tgaagactac agcacctcgc cggtactgtg      480

tgaggcccaa cagtggaatt attgacccag ggtcaactgt gactgtttca gtaatgctac      540

agccctttga ctatgatccg aatgaaaaga gtaaacacaa gtttatggta cagacaattt      600

ttgctccacc aaacacttca gatatggaag ctgtgtggaa agaggcaaaa cctgatgaat      660

taatggattc caaattgaga tgcgtatttg aaatgcccaa tgaaaatgat aaattgaatg      720

atatggaacc tagcaaagct gttccactga atgcatctaa gcaagatgga cctatgccaa      780

aaccacacag tgtttcactt aatgataccg aaacaaggaa actaatggaa gagtgtaaaa      840

gacttcaggg agaaatgatg aagctatcag aagaaaatcg gcacctgaga gatgaaggtt      900

taaggctcag aaaggtagca cattcggata aacctggatc aacctcaact gcatccttca      960

gagataatgt caccagtcct cttccttcac ttcttgttgt aattgcagcc attttcattg     1020

gattctttct agggaaattc atcttgtaga gtgaagcatg cagagtgctg tttctttttt     1080

tttttttctc ttgaccagaa aaagatttgt ttacctacca tttcattggt agtatggccc     1140

acggtgacca tttttttgtg tgtacagcgt catataggct ttgcctttaa tgatctctta     1200

cggttagaaa acacaataaa aacaaactgt tcggctactg gacaggttgt atattaccag     1260

atcatcacta gcagatgtca gttgcacatt gagtccttta tgaaattcat aaataaagaa     1320

ttgttctttc tttgtggttt taataagagt tcaagaattg ttcagagtct tgtaaatgtt     1380

attttaataa tccctttaaa ttttatctgt tgctgttacc tcttgaaata tgatttattt     1440

agattgctaa tcccactcat tcaggaaatg ccaagaggta ttccttgggg aaatggtgcc     1500

tcttacagtg taaatttttc ctcctttacc tttgctaata tcatggcaga atttttctta     1560

tcccttgtga ggcagttgtt gactgagttt ttcatcctta caatcctgtc ccatggtatt     1620

taacataaaa aaaaataaaa ctgttaacag attcttgctc gatagcttgt ttgtgtctgt     1680

cgtgttatta gagggaactc cactatatat ggtcacttga aattatgatg caaaggtttc     1740

tcttgcattg aaaccctctt ggatattaca gtatttttaa ttgaaagtcc taattctgtt     1800

aaggaaagga gttgattaaa ttttaaggta ccactggtat tttgggagat tataatcagt     1860

ttgttttcaa gataatagaa aataaggtcc atgagaatag aagttatgtg atttcagtga     1920

gttgatgtgt acagcatggc tgtgctccat ctgatttacc ccattcttaa gttctgagag     1980

tatgttctca aggaagattt aactctcttt ggttttaaat tactttttaa ccagcctaat     2040

aaataagtct tactactttt cataatattt cataatagtt aaaagtaggt gtttttttcg     2100

tgctcaattt ggcactcaaa ataatgttca ttatggaagt ttggtaatac tgagcaagcc     2160

tgtggaattt tctttatgaa aaatgatttt agcctttgca aatgttaacc atgtgaaaca     2220

cattttcagt ataagtatgc gttacagggt ttgatacttt cctgcactta ggtttgtcct     2280

attcttcatt tattcatact aggatagaaa attttggaat cagaaaatag atccagtgtt     2340

tagctacata caatctagta caagtgaatt tttattctta aacataggtg tgttggctct     2400

ttttttaaaa gatgcgctct acctgaaaag gaaattggat tttagaactg gatgtggtgc     2460

agtgaagtat tttaggccca ggtctgtgta cacattttat agaagaatga agtactctga     2520

agtattttgg ttgccttttc atttcaactg tgttttgaat ttgtcagatc acacatatat     2580

tgtgttattg ggcgctgtgg tatcttttat aaaacctctt gcttgtgtgc aaaagttcct     2640

aaaaggaaac acaagtaatg cctatccatt actagcatgc tatgctgcat gctttactgc     2700

cattgctgta tgctttactg tctttgtaaa aatccccctc tccccttttc tggtaactgg     2760

aaaagcatgc taaaaatagt cttatatttt caccccataa atgcagaatc agtaattcct     2820

tggcttaaag ctcttatata atcaatatta ttggtggtaa ataccaagtt tggtatctca     2880

tagctatctt tttttaaaga aattaagttc ttgaaaattt agccaaatcc cgttttatgg     2940

gaatgctctt tagaattcat tttgttcagc ccctttgttc tatggttgag aaatctgagg     3000

ccttacgaag gttaagagaa ctttccccgt gtctcacagg taggtagagg cagagctgga     3060

actagatatc tggtctgttg actctagctc agtgtcttct ggtaactgtt gaaaattgtc     3120

ttagtttgag agatggctga aataatgaac ataaaatgct atttataata acaagtatat     3180

gtgaaatttc ttattgtaag actactaccg gcttactgtt gaatagtttg gttatagtgt     3240

ttaggctaga aatgcctccc acattggtaa taaacattac aaaatacaat gtatttttag     3300

gtaggcattt tataaaatgc attatgccat ggttgctttt gagatagatt gtagtctggg     3360

tagcatcttt aaaatgtatg tgggcttaac tgttgttcat atcaggagat gctctgattg     3420

tataggtgag actctgtttc tgttattttt aattgctgta tgaaatgtga tcagattatt     3480

ttactaccaa cagttatagt ttgaaagtcc aactgtatta attgactgat aatatgataa     3540

tatagagatt aaattgtttg tcttcattcc ttatatgttt agaagttttt gctttgtctg     3600

cctgcttact tgtatatgta agcatgaggg aaatacactg ttgctaatac tgaaattaca     3660

atcaagtaac taaggccttg agttcatatg tgacactgaa tgcactagct tccttcgttc     3720

tataactaat gtaccttaac ttcccccatt cttatattta caagaagcta agtcattatg     3780

ttctgagtgt gtggtatgtt cccttaaaaa aaaatgacac ttggaagaaa aatgtatgaa     3840

attcagaaat tccgatcaaa gaaaagtaat tctttctttt tttttttgag acagagtctt     3900

gctttgttgc ccaggctgga gggcagtggt gtgatctcac ctcactgcag cttccgcctc     3960

ctgggttcaa gtgattctca tggctcagcc gcctgagtag ctgggattac aggtgtgagc     4020

caacaagccc ggctaatttt tgtattttta gtagagacaa ggtttcacca tgttggtcag     4080

gctgggctca aactcctgaa tccgcctgcc tcggcctccc aaagtgctgg gattacaggt     4140

gtgagctgcc gcacccagcc aagaaaaata atactcttaa atacttagat gttcacctaa     4200

agttgatatt atttggtatg ggaattactt ttgaactgta atctttcaga ttacaccact     4260

ttgaaaacaa gttttaacag tagggtaaaa atatagtttt tgagggtatt cccaacttgt     4320

gatcttctac cactttagag acattcaagt aatagttttc ttagagcttt gcacattcct     4380

attcactgag attttaaaaa tttcaccttt attcgaggga aggatcaatg cttattacca     4440

tttggaaaaa cgaagatcag aaggtaaatg atctttattt tctagcttta aagggaaatt     4500

aaaccattca tgaataaact ttaaaaatgt gaagtgtcct tttccttttc acaatacaaa     4560

aaaaatttca acagattgtg tggtttgtgc atttatatcc tgttaagcat taatagctaa     4620

tcactgggac ttgaattctg atggcagata gtctcttgct tagtgagatg gagttaacta     4680

ttttttagta ggaagtgaga acagctgatt ttcatgccac gtttcatagc cccacttttg     4740

gtagactacc accacgcttc ttcgcgtaag cagtggcatc ttgggaatga atgcccagcc     4800

gctcgtgggt tggtgcaaag aagtataaac atatatcact aaggaaaaag aaagtttgtc     4860

ttgcccttct gacacagtgt gtgcacttca ggcaattttt ggaaaatata aaaaattcca     4920

aattctgcct ttcagcagca tcaattgcta ggaacatttc attcatttcc ctgtaatatt     4980

aatgttcttt aagcataatc actaattata agttgtatcc tatttttttc cagcttaatt     5040

tctgtggttt attgaaaacc aagtataaat gtgactaaaa gcattttgct ttgtttttat     5100

agttaacttt cttaaggtta tggacatttt ataatgtaac atttgattgg cctggcctct     5160

tgacaattcc cttctagtta tgcatatcct cctgttgcca catttcttgt tttaaaactc     5220

agtttcttgt tttccagttg ttgctatgta taacacccat cttgaaagag agtatatagg     5280

aagttattca gataactttt gtagtagtga tattcaacta tagcagtacc ttaactcatg     5340

atgagcttag gaacataaaa gataattgtt gcttgaatag cacccccaga gatactgacc     5400

taattggtct ggggtggaga tctggcatgg tagttttttt caagctccaa tcatcggcca     5460

gacagttgct ttatgtaggt ttttaaatgc caaaggcaga tatgaagtag atttaattaa     5520

gacttgactt cagcaataca ggggaactta aaatacttat ttttctttaa actgcaggag     5580

tcactgttag gtattgctta aaaaaaattg cataaaagct ttgcttgtca agttaggatt     5640

gctggaatac cactaaagat ttttgacttg tgaataaatg agctgtcatc gcaaaaaggc     5700

gatttgagaa atgtgggctt cagtattaat tgccattttg ctgacaccca gtgtacctac     5760

ctacctgaga aatttatttt gtccatcatg tatttctcaa agcaaaaggt ggttttcaag     5820

tataatgtcg ttttcaacat gcttattact tagttttacg tcagctcatt tcatcatcat     5880

tgataacttg tgaaatactt atctccatcc tatggaatag gggagacggg tttagacagg     5940

ttcaattagc tcaagtctac acagctgaag tagcagagaa agtgggatct agatggtctg     6000

atcctagtga tctaccatat gaaggacata gtttgtgtcc tggtccaagt caaatattga     6060

ctcctcacaa acagtaagta tggcaatttt gtgatgcctt tgattccact ttacatggag     6120

tactattatt tgtgaaatgt ctttaagatt tttggtctta aatttttgaa gactgctttc     6180

cccctttatc tcccagaaaa ttgagaagaa gtaaactcct gcccactaac aatctcagtc     6240

cgtgaacaaa accaacatga acattcctaa acaagagtgt gtgttactct aagaagaagg     6300

ctatagaatt tatggaaatg gcttatgtaa cctacaagac tggagaacag aatgtgactg     6360

gccttttcta atggtccttt aagatttaat gattaaagca agagtttttt ataattgact     6420

ttgtggtcta aattcttgat actgtttata attctacaaa gaacaaaaat tgttatgtac     6480

tataggcact taagaaccct gaggaaaaat aatacaatgt gtgtgtgtga gagagagagt     6540

gagttactga cattgttcca aaaaaaaaaa aaaaaaaaaa aaaaatgtgg agggttgaaa     6600

tggtaaggaa ttggaatctt ttgtattttc gagcaataag aattcctatt cttgtttcaa     6660

atagaggttt gttaggaatt acagttgtgg ggagcaaact ttcttttttg tgctgtttta     6720

attcaaaatg tatatcctta attgtatata atatgtagat aaatatatga gggtattaag     6780

ctactttgaa ttaaatttaa ggatatattt cacatgaaaa caaatacaaa cgagaatcaa     6840

aataaagttt tgcaaagta                                                  6859


<210> 158
<211> 249
<212> PRT
<213> Homo sapiens

<400> 158
Met Ala Ser Ala Ser Gly Ala Met Ala Lys His Glu Gln Ile Leu Val 
1               5                   10                  15      


Leu Asp Pro Pro Thr Asp Leu Lys Phe Lys Gly Pro Phe Thr Asp Val 
            20                  25                  30          


Val Thr Thr Asn Leu Lys Leu Arg Asn Pro Ser Asp Arg Lys Val Cys 
        35                  40                  45              


Phe Lys Val Lys Thr Thr Ala Pro Arg Arg Tyr Cys Val Arg Pro Asn 
    50                  55                  60                  


Ser Gly Ile Ile Asp Pro Gly Ser Thr Val Thr Val Ser Val Met Leu 
65                  70                  75                  80  


Gln Pro Phe Asp Tyr Asp Pro Asn Glu Lys Ser Lys His Lys Phe Met 
                85                  90                  95      


Val Gln Thr Ile Phe Ala Pro Pro Asn Thr Ser Asp Met Glu Ala Val 
            100                 105                 110         


Trp Lys Glu Ala Lys Pro Asp Glu Leu Met Asp Ser Lys Leu Arg Cys 
        115                 120                 125             


Val Phe Glu Met Pro Asn Glu Asn Asp Lys Leu Asn Asp Met Glu Pro 
    130                 135                 140                 


Ser Lys Ala Val Pro Leu Asn Ala Ser Lys Gln Asp Gly Pro Met Pro 
145                 150                 155                 160 


Lys Pro His Ser Val Ser Leu Asn Asp Thr Glu Thr Arg Lys Leu Met 
                165                 170                 175     


Glu Glu Cys Lys Arg Leu Gln Gly Glu Met Met Lys Leu Ser Glu Glu 
            180                 185                 190         


Asn Arg His Leu Arg Asp Glu Gly Leu Arg Leu Arg Lys Val Ala His 
        195                 200                 205             


Ser Asp Lys Pro Gly Ser Thr Ser Thr Ala Ser Phe Arg Asp Asn Val 
    210                 215                 220                 


Thr Ser Pro Leu Pro Ser Leu Leu Val Val Ile Ala Ala Ile Phe Ile 
225                 230                 235                 240 


Gly Phe Phe Leu Gly Lys Phe Ile Leu 
                245                 


<210> 159
<211> 2257
<212> DNA
<213> Homo sapiens

<400> 159
cttccgtcgg ccattttagg tggtccgcgg cggcgccatt aaagcgagga ggaggcgaga       60

gcggccgccg ctggtgctta ttctttttta gtgcagcggg agagagcggg agtgtgcgcc      120

gcgcgagagt gggaggcgaa gggggcaggc cagggagagg cgcaggagcc tttgcagcca      180

cgcgcgcgcc ttccctgtct tgtgtgcttc gcgaggtaga gcgggcgcgc ggcagcggcg      240

gggattactt tgctgctagt ttcggttcgc ggcagcggcg ggtgtagtct cggcggcagc      300

ggcggagaca ctagcactat gtcggaggag cagttcggcg gggacggggc ggcggcagcg      360

gcaacggcgg cggtaggcgg ctcggcgggc gagcaggagg gagccatggt ggcggcgaca      420

cagggggcag cggcggcggc gggaagcgga gccgggaccg ggggcggaac cgcgtctgga      480

ggcaccgaag ggggcagcgc cgagtcggag ggggcgaaga ttgacgccag taagaacgag      540

gaggatgaag gccattcaaa ctcctcccca cgacactctg aagcagcgac ggcacagcgg      600

gaagaatgga aaatgtttat aggaggcctt agctgggaca ctacaaagaa agatctgaag      660

gactactttt ccaaatttgg tgaagttgta gactgcactc tgaagttaga tcctatcaca      720

gggcgatcaa ggggttttgg ctttgtgcta tttaaagaat cggagagtgt agataaggtc      780

atggatcaaa aagaacataa attgaatggg aaggtgattg atcctaaaag ggccaaagcc      840

atgaaaacaa aagagccggt taaaaaaatt tttgttggtg gcctttctcc agatacacct      900

gaagagaaaa taagggagta ctttggtggt tttggtgagg tggaatccat agagctcccc      960

atggacaaca agaccaataa gaggcgtggg ttctgcttta ttacctttaa ggaagaagaa     1020

ccagtgaaga agataatgga aaagaaatac cacaatgttg gtcttagtaa atgtgaaata     1080

aaagtagcca tgtcgaagga acaatatcag caacagcaac agtggggatc tagaggagga     1140

tttgcaggaa gagctcgtgg aagaggtggt ggccccagtc aaaactggaa ccagggatat     1200

agtaactatt ggaatcaagg ctatggcaac tatggatata acagccaagg ttacggtggt     1260

tatggaggat atgactacac tggttacaac aactactatg gatatggtga ttatagcaac     1320

cagcagagtg gttatgggaa ggtatccagg cgaggtggtc atcaaaatag ctacaaacca     1380

tactaaatta ttccatttgc aacttatccc caacaggtgg tgaagcagta ttttccaatt     1440

tgaagattca tttgaaggtg gctcctgcca cctgctaata gcagttcaaa ctaaattttt     1500

tgtatcaagt ccctgaatgg aagtatgacg ttgggtccct ctgaagttta attctgagtt     1560

ctcattaaaa gaaatttgct ttcattgttt tatttcttaa ttgctatgct tcagaatcaa     1620

tttgtgtttt atgccctttc ccccagtatt gtagagcaag tcttgtgtta aaagcccagt     1680

gtgacagtgt catgatgtag tagtgtctta ctggtttttt aataaatcct tttgtataaa     1740

aatgtattgg ctcttttatc atcagaatag gaaaaattgt catggattca agttattaaa     1800

agcataagtt tggaagacag gcttgccgaa attgaggaca tgattaaaat tgcagtgaag     1860

tttgaaatgt ttttagcaaa atctaatttt tgccataatg tgtcctccct gtccaaattg     1920

ggaatgactt aatgtcaatt tgtttgttgg ttgttttaat aatacttcct tatgtagcca     1980

ttaagattta tatgaatatt ttcccaaatg cccagttttt gcttaatatg tattgtgctt     2040

tttagaacaa atctggataa atgtgcaaaa gtaccccttt gcacagatag ttaatgtttt     2100

atgcttccat taaataaaaa ggacttaaaa tctgttaatt ataatagaaa tgcggctagt     2160

tcagagagat ttttagagct gtggtggact tcatagatga attcaagtgt tgagggagga     2220

ttaaagaaat atataccgtg tttatgtgtg tgtgctt                              2257


<210> 160
<211> 355
<212> PRT
<213> Homo sapiens

<400> 160
Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly His Ser 
65                  70                  75                  80  


Asn Ser Ser Pro Arg His Ser Glu Ala Ala Thr Ala Gln Arg Glu Glu 
                85                  90                  95      


Trp Lys Met Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp 
            100                 105                 110         


Leu Lys Asp Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu 
        115                 120                 125             


Lys Leu Asp Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu 
    130                 135                 140                 


Phe Lys Glu Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His 
145                 150                 155                 160 


Lys Leu Asn Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys 
                165                 170                 175     


Thr Lys Glu Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp 
            180                 185                 190         


Thr Pro Glu Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val 
        195                 200                 205             


Glu Ser Ile Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly 
    210                 215                 220                 


Phe Cys Phe Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met 
225                 230                 235                 240 


Glu Lys Lys Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val 
                245                 250                 255     


Ala Met Ser Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg 
            260                 265                 270         


Gly Gly Phe Ala Gly Arg Ala Arg Gly Arg Gly Gly Gly Pro Ser Gln 
        275                 280                 285             


Asn Trp Asn Gln Gly Tyr Ser Asn Tyr Trp Asn Gln Gly Tyr Gly Asn 
    290                 295                 300                 


Tyr Gly Tyr Asn Ser Gln Gly Tyr Gly Gly Tyr Gly Gly Tyr Asp Tyr 
305                 310                 315                 320 


Thr Gly Tyr Asn Asn Tyr Tyr Gly Tyr Gly Asp Tyr Ser Asn Gln Gln 
                325                 330                 335     


Ser Gly Tyr Gly Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr 
            340                 345                 350         


Lys Pro Tyr 
        355 


<210> 161
<211> 2200
<212> DNA
<213> Homo sapiens

<400> 161
cttccgtcgg ccattttagg tggtccgcgg cggcgccatt aaagcgagga ggaggcgaga       60

gcggccgccg ctggtgctta ttctttttta gtgcagcggg agagagcggg agtgtgcgcc      120

gcgcgagagt gggaggcgaa gggggcaggc cagggagagg cgcaggagcc tttgcagcca      180

cgcgcgcgcc ttccctgtct tgtgtgcttc gcgaggtaga gcgggcgcgc ggcagcggcg      240

gggattactt tgctgctagt ttcggttcgc ggcagcggcg ggtgtagtct cggcggcagc      300

ggcggagaca ctagcactat gtcggaggag cagttcggcg gggacggggc ggcggcagcg      360

gcaacggcgg cggtaggcgg ctcggcgggc gagcaggagg gagccatggt ggcggcgaca      420

cagggggcag cggcggcggc gggaagcgga gccgggaccg ggggcggaac cgcgtctgga      480

ggcaccgaag ggggcagcgc cgagtcggag ggggcgaaga ttgacgccag taagaacgag      540

gaggatgaag ggaaaatgtt tataggaggc cttagctggg acactacaaa gaaagatctg      600

aaggactact tttccaaatt tggtgaagtt gtagactgca ctctgaagtt agatcctatc      660

acagggcgat caaggggttt tggctttgtg ctatttaaag aatcggagag tgtagataag      720

gtcatggatc aaaaagaaca taaattgaat gggaaggtga ttgatcctaa aagggccaaa      780

gccatgaaaa caaaagagcc ggttaaaaaa atttttgttg gtggcctttc tccagataca      840

cctgaagaga aaataaggga gtactttggt ggttttggtg aggtggaatc catagagctc      900

cccatggaca acaagaccaa taagaggcgt gggttctgct ttattacctt taaggaagaa      960

gaaccagtga agaagataat ggaaaagaaa taccacaatg ttggtcttag taaatgtgaa     1020

ataaaagtag ccatgtcgaa ggaacaatat cagcaacagc aacagtgggg atctagagga     1080

ggatttgcag gaagagctcg tggaagaggt ggtggcccca gtcaaaactg gaaccaggga     1140

tatagtaact attggaatca aggctatggc aactatggat ataacagcca aggttacggt     1200

ggttatggag gatatgacta cactggttac aacaactact atggatatgg tgattatagc     1260

aaccagcaga gtggttatgg gaaggtatcc aggcgaggtg gtcatcaaaa tagctacaaa     1320

ccatactaaa ttattccatt tgcaacttat ccccaacagg tggtgaagca gtattttcca     1380

atttgaagat tcatttgaag gtggctcctg ccacctgcta atagcagttc aaactaaatt     1440

ttttgtatca agtccctgaa tggaagtatg acgttgggtc cctctgaagt ttaattctga     1500

gttctcatta aaagaaattt gctttcattg ttttatttct taattgctat gcttcagaat     1560

caatttgtgt tttatgccct ttcccccagt attgtagagc aagtcttgtg ttaaaagccc     1620

agtgtgacag tgtcatgatg tagtagtgtc ttactggttt tttaataaat ccttttgtat     1680

aaaaatgtat tggctctttt atcatcagaa taggaaaaat tgtcatggat tcaagttatt     1740

aaaagcataa gtttggaaga caggcttgcc gaaattgagg acatgattaa aattgcagtg     1800

aagtttgaaa tgtttttagc aaaatctaat ttttgccata atgtgtcctc cctgtccaaa     1860

ttgggaatga cttaatgtca atttgtttgt tggttgtttt aataatactt ccttatgtag     1920

ccattaagat ttatatgaat attttcccaa atgcccagtt tttgcttaat atgtattgtg     1980

ctttttagaa caaatctgga taaatgtgca aaagtacccc tttgcacaga tagttaatgt     2040

tttatgcttc cattaaataa aaaggactta aaatctgtta attataatag aaatgcggct     2100

agttcagaga gatttttaga gctgtggtgg acttcataga tgaattcaag tgttgaggga     2160

ggattaaaga aatatatacc gtgtttatgt gtgtgtgctt                           2200


<210> 162
<211> 336
<212> PRT
<213> Homo sapiens

<400> 162
Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly Lys Met 
65                  70                  75                  80  


Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp Leu Lys Asp 
                85                  90                  95      


Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu Lys Leu Asp 
            100                 105                 110         


Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu Phe Lys Glu 
        115                 120                 125             


Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His Lys Leu Asn 
    130                 135                 140                 


Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys Thr Lys Glu 
145                 150                 155                 160 


Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp Thr Pro Glu 
                165                 170                 175     


Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val Glu Ser Ile 
            180                 185                 190         


Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly Phe Cys Phe 
        195                 200                 205             


Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met Glu Lys Lys 
    210                 215                 220                 


Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val Ala Met Ser 
225                 230                 235                 240 


Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg Gly Gly Phe 
                245                 250                 255     


Ala Gly Arg Ala Arg Gly Arg Gly Gly Gly Pro Ser Gln Asn Trp Asn 
            260                 265                 270         


Gln Gly Tyr Ser Asn Tyr Trp Asn Gln Gly Tyr Gly Asn Tyr Gly Tyr 
        275                 280                 285             


Asn Ser Gln Gly Tyr Gly Gly Tyr Gly Gly Tyr Asp Tyr Thr Gly Tyr 
    290                 295                 300                 


Asn Asn Tyr Tyr Gly Tyr Gly Asp Tyr Ser Asn Gln Gln Ser Gly Tyr 
305                 310                 315                 320 


Gly Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr Lys Pro Tyr 
                325                 330                 335     


<210> 163
<211> 2110
<212> DNA
<213> Homo sapiens

<400> 163
cttccgtcgg ccattttagg tggtccgcgg cggcgccatt aaagcgagga ggaggcgaga       60

gcggccgccg ctggtgctta ttctttttta gtgcagcggg agagagcggg agtgtgcgcc      120

gcgcgagagt gggaggcgaa gggggcaggc cagggagagg cgcaggagcc tttgcagcca      180

cgcgcgcgcc ttccctgtct tgtgtgcttc gcgaggtaga gcgggcgcgc ggcagcggcg      240

gggattactt tgctgctagt ttcggttcgc ggcagcggcg ggtgtagtct cggcggcagc      300

ggcggagaca ctagcactat gtcggaggag cagttcggcg gggacggggc ggcggcagcg      360

gcaacggcgg cggtaggcgg ctcggcgggc gagcaggagg gagccatggt ggcggcgaca      420

cagggggcag cggcggcggc gggaagcgga gccgggaccg ggggcggaac cgcgtctgga      480

ggcaccgaag ggggcagcgc cgagtcggag ggggcgaaga ttgacgccag taagaacgag      540

gaggatgaag gccattcaaa ctcctcccca cgacactctg aagcagcgac ggcacagcgg      600

gaagaatgga aaatgtttat aggaggcctt agctgggaca ctacaaagaa agatctgaag      660

gactactttt ccaaatttgg tgaagttgta gactgcactc tgaagttaga tcctatcaca      720

gggcgatcaa ggggttttgg ctttgtgcta tttaaagaat cggagagtgt agataaggtc      780

atggatcaaa aagaacataa attgaatggg aaggtgattg atcctaaaag ggccaaagcc      840

atgaaaacaa aagagccggt taaaaaaatt tttgttggtg gcctttctcc agatacacct      900

gaagagaaaa taagggagta ctttggtggt tttggtgagg tggaatccat agagctcccc      960

atggacaaca agaccaataa gaggcgtggg ttctgcttta ttacctttaa ggaagaagaa     1020

ccagtgaaga agataatgga aaagaaatac cacaatgttg gtcttagtaa atgtgaaata     1080

aaagtagcca tgtcgaagga acaatatcag caacagcaac agtggggatc tagaggagga     1140

tttgcaggaa gagctcgtgg aagaggtggt gaccagcaga gtggttatgg gaaggtatcc     1200

aggcgaggtg gtcatcaaaa tagctacaaa ccatactaaa ttattccatt tgcaacttat     1260

ccccaacagg tggtgaagca gtattttcca atttgaagat tcatttgaag gtggctcctg     1320

ccacctgcta atagcagttc aaactaaatt ttttgtatca agtccctgaa tggaagtatg     1380

acgttgggtc cctctgaagt ttaattctga gttctcatta aaagaaattt gctttcattg     1440

ttttatttct taattgctat gcttcagaat caatttgtgt tttatgccct ttcccccagt     1500

attgtagagc aagtcttgtg ttaaaagccc agtgtgacag tgtcatgatg tagtagtgtc     1560

ttactggttt tttaataaat ccttttgtat aaaaatgtat tggctctttt atcatcagaa     1620

taggaaaaat tgtcatggat tcaagttatt aaaagcataa gtttggaaga caggcttgcc     1680

gaaattgagg acatgattaa aattgcagtg aagtttgaaa tgtttttagc aaaatctaat     1740

ttttgccata atgtgtcctc cctgtccaaa ttgggaatga cttaatgtca atttgtttgt     1800

tggttgtttt aataatactt ccttatgtag ccattaagat ttatatgaat attttcccaa     1860

atgcccagtt tttgcttaat atgtattgtg ctttttagaa caaatctgga taaatgtgca     1920

aaagtacccc tttgcacaga tagttaatgt tttatgcttc cattaaataa aaaggactta     1980

aaatctgtta attataatag aaatgcggct agttcagaga gatttttaga gctgtggtgg     2040

acttcataga tgaattcaag tgttgaggga ggattaaaga aatatatacc gtgtttatgt     2100

gtgtgtgctt                                                            2110


<210> 164
<211> 306
<212> PRT
<213> Homo sapiens

<400> 164
Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly His Ser 
65                  70                  75                  80  


Asn Ser Ser Pro Arg His Ser Glu Ala Ala Thr Ala Gln Arg Glu Glu 
                85                  90                  95      


Trp Lys Met Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp 
            100                 105                 110         


Leu Lys Asp Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu 
        115                 120                 125             


Lys Leu Asp Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu 
    130                 135                 140                 


Phe Lys Glu Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His 
145                 150                 155                 160 


Lys Leu Asn Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys 
                165                 170                 175     


Thr Lys Glu Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp 
            180                 185                 190         


Thr Pro Glu Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val 
        195                 200                 205             


Glu Ser Ile Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly 
    210                 215                 220                 


Phe Cys Phe Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met 
225                 230                 235                 240 


Glu Lys Lys Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val 
                245                 250                 255     


Ala Met Ser Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg 
            260                 265                 270         


Gly Gly Phe Ala Gly Arg Ala Arg Gly Arg Gly Gly Asp Gln Gln Ser 
        275                 280                 285             


Gly Tyr Gly Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr Lys 
    290                 295                 300                 


Pro Tyr 
305     


<210> 165
<211> 2053
<212> DNA
<213> Homo sapiens

<400> 165
cttccgtcgg ccattttagg tggtccgcgg cggcgccatt aaagcgagga ggaggcgaga       60

gcggccgccg ctggtgctta ttctttttta gtgcagcggg agagagcggg agtgtgcgcc      120

gcgcgagagt gggaggcgaa gggggcaggc cagggagagg cgcaggagcc tttgcagcca      180

cgcgcgcgcc ttccctgtct tgtgtgcttc gcgaggtaga gcgggcgcgc ggcagcggcg      240

gggattactt tgctgctagt ttcggttcgc ggcagcggcg ggtgtagtct cggcggcagc      300

ggcggagaca ctagcactat gtcggaggag cagttcggcg gggacggggc ggcggcagcg      360

gcaacggcgg cggtaggcgg ctcggcgggc gagcaggagg gagccatggt ggcggcgaca      420

cagggggcag cggcggcggc gggaagcgga gccgggaccg ggggcggaac cgcgtctgga      480

ggcaccgaag ggggcagcgc cgagtcggag ggggcgaaga ttgacgccag taagaacgag      540

gaggatgaag ggaaaatgtt tataggaggc cttagctggg acactacaaa gaaagatctg      600

aaggactact tttccaaatt tggtgaagtt gtagactgca ctctgaagtt agatcctatc      660

acagggcgat caaggggttt tggctttgtg ctatttaaag aatcggagag tgtagataag      720

gtcatggatc aaaaagaaca taaattgaat gggaaggtga ttgatcctaa aagggccaaa      780

gccatgaaaa caaaagagcc ggttaaaaaa atttttgttg gtggcctttc tccagataca      840

cctgaagaga aaataaggga gtactttggt ggttttggtg aggtggaatc catagagctc      900

cccatggaca acaagaccaa taagaggcgt gggttctgct ttattacctt taaggaagaa      960

gaaccagtga agaagataat ggaaaagaaa taccacaatg ttggtcttag taaatgtgaa     1020

ataaaagtag ccatgtcgaa ggaacaatat cagcaacagc aacagtgggg atctagagga     1080

ggatttgcag gaagagctcg tggaagaggt ggtgaccagc agagtggtta tgggaaggta     1140

tccaggcgag gtggtcatca aaatagctac aaaccatact aaattattcc atttgcaact     1200

tatccccaac aggtggtgaa gcagtatttt ccaatttgaa gattcatttg aaggtggctc     1260

ctgccacctg ctaatagcag ttcaaactaa attttttgta tcaagtccct gaatggaagt     1320

atgacgttgg gtccctctga agtttaattc tgagttctca ttaaaagaaa tttgctttca     1380

ttgttttatt tcttaattgc tatgcttcag aatcaatttg tgttttatgc cctttccccc     1440

agtattgtag agcaagtctt gtgttaaaag cccagtgtga cagtgtcatg atgtagtagt     1500

gtcttactgg ttttttaata aatccttttg tataaaaatg tattggctct tttatcatca     1560

gaataggaaa aattgtcatg gattcaagtt attaaaagca taagtttgga agacaggctt     1620

gccgaaattg aggacatgat taaaattgca gtgaagtttg aaatgttttt agcaaaatct     1680

aatttttgcc ataatgtgtc ctccctgtcc aaattgggaa tgacttaatg tcaatttgtt     1740

tgttggttgt tttaataata cttccttatg tagccattaa gatttatatg aatattttcc     1800

caaatgccca gtttttgctt aatatgtatt gtgcttttta gaacaaatct ggataaatgt     1860

gcaaaagtac ccctttgcac agatagttaa tgttttatgc ttccattaaa taaaaaggac     1920

ttaaaatctg ttaattataa tagaaatgcg gctagttcag agagattttt agagctgtgg     1980

tggacttcat agatgaattc aagtgttgag ggaggattaa agaaatatat accgtgttta     2040

tgtgtgtgtg ctt                                                        2053


<210> 166
<211> 287
<212> PRT
<213> Homo sapiens

<400> 166
Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly Lys Met 
65                  70                  75                  80  


Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp Leu Lys Asp 
                85                  90                  95      


Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu Lys Leu Asp 
            100                 105                 110         


Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu Phe Lys Glu 
        115                 120                 125             


Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His Lys Leu Asn 
    130                 135                 140                 


Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys Thr Lys Glu 
145                 150                 155                 160 


Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp Thr Pro Glu 
                165                 170                 175     


Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val Glu Ser Ile 
            180                 185                 190         


Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly Phe Cys Phe 
        195                 200                 205             


Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met Glu Lys Lys 
    210                 215                 220                 


Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val Ala Met Ser 
225                 230                 235                 240 


Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg Gly Gly Phe 
                245                 250                 255     


Ala Gly Arg Ala Arg Gly Arg Gly Gly Asp Gln Gln Ser Gly Tyr Gly 
            260                 265                 270         


Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr Lys Pro Tyr 
        275                 280                 285         


<210> 167
<211> 2107
<212> DNA
<213> Homo sapiens

<400> 167
gtacatgcga gcgtgtgcgc gcgtgcgcag gcggggcgac cggcgtcccc ggcgctcgcc       60

ccgcccccga gatgacgccg tgcgtgcgcg cgcccggtcc gcgcctccgc cgctttttat      120

agcggccgcg ggcggcggcg gcagcggttg gaggttgtag gaccggcgag gaataggaat      180

catggcggct gcgctgttcg tgctgctggg attcgcgctg ctgggcaccc acggagcctc      240

cggggctgcc ggcttcgtcc aggcgccgct gtcccagcag aggtgggtgg ggggcagtgt      300

ggagctgcac tgcgaggccg tgggcagccc ggtgcccgag atccagtggt ggtttgaagg      360

gcagggtccc aacgacacct gctcccagct ctgggacggc gcccggctgg accgcgtcca      420

catccacgcc acctaccacc agcacgcggc cagcaccatc tccatcgaca cgctcgtgga      480

ggaggacacg ggcacttacg agtgccgggc cagcaacgac ccggatcgca accacctgac      540

ccgggcgccc agggtcaagt gggtccgcgc ccaggcagtc gtgctagtcc tggaacccgg      600

cacagtcttc actaccgtag aagaccttgg ctccaagata ctcctcacct gctccttgaa      660

tgacagcgcc acagaggtca cagggcaccg ctggctgaag gggggcgtgg tgctgaagga      720

ggacgcgctg cccggccaga aaacggagtt caaggtggac tccgacgacc agtggggaga      780

gtactcctgc gtcttcctcc ccgagcccat gggcacggcc aacatccagc tccacgggcc      840

tcccagagtg aaggctgtga agtcgtcaga acacatcaac gagggggaga cggccatgct      900

ggtctgcaag tcagagtccg tgccacctgt cactgactgg gcctggtaca agatcactga      960

ctctgaggac aaggccctca tgaacggctc cgagagcagg ttcttcgtga gttcctcgca     1020

gggccggtca gagctacaca ttgagaacct gaacatggag gccgaccccg gccagtaccg     1080

gtgcaacggc accagctcca agggctccga ccaggccatc atcacgctcc gcgtgcgcag     1140

ccacctggcc gccctctggc ccttcctggg catcgtggct gaggtgctgg tgctggtcac     1200

catcatcttc atctacgaga agcgccggaa gcccgaggac gtcctggatg atgacgacgc     1260

cggctctgca cccctgaaga gcagcgggca gcaccagaat gacaaaggca agaacgtccg     1320

ccagaggaac tcttcctgag gcaggtggcc cgaggacgct ccctgctcca cgtctgcgcc     1380

gccgccggag tccactccca gtgcttgcaa gattccaagt tctcacctct taaagaaaac     1440

ccaccccgta gattcccatc atacacttcc ttctttttta aaaaagttgg gttttctcca     1500

ttcaggattc tgttccttag gtttttttcc ttctgaagtg tttcacgaga gcccgggagc     1560

tgctgccctg cggccccgtc tgtggctttc agcctctggg tctgagtcat ggccgggtgg     1620

gcggcacagc cttctccact ggccggagtc agtgccaggt ccttgccctt tgtggaaagt     1680

cacaggtcac acgaggggcc ccgtgtcctg cctgtctgaa gccaatgctg tctggttgcg     1740

ccatttttgt gcttttatgt ttaattttat gagggccacg ggtctgtgtt cgactcagcc     1800

tcagggacga ctctgacctc ttggccacag aggactcact tgcccacacc gagggcgacc     1860

ccgtcacagc ctcaagtcac tcccaagccc cctccttgtc tgtgcatccg ggggcagctc     1920

tggagggggt ttgctgggga actggcgcca tcgccgggac tccagaaccg cagaagcctc     1980

cccagctcac ccctggagga cggccggctc tctatagcac cagggctcac gtgggaaccc     2040

ccctcccacc caccgccaca ataaagatcg cccccacctc caccctcaaa aaaaaaaaaa     2100

aaaaaaa                                                               2107


<210> 168
<211> 385
<212> PRT
<213> Homo sapiens

<400> 168
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 
    130                 135                 140                 


Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210> 169
<211> 1759
<212> DNA
<213> Homo sapiens

<400> 169
gtacatgcga gcgtgtgcgc gcgtgcgcag gcggggcgac cggcgtcccc ggcgctcgcc       60

ccgcccccga gatgacgccg tgcgtgcgcg cgcccggtcc gcgcctccgc cgctttttat      120

agcggccgcg ggcggcggcg gcagcggttg gaggttgtag gaccggcgag gaataggaat      180

catggcggct gcgctgttcg tgctgctggg attcgcgctg ctgggcaccc acggagcctc      240

cggggctgcc ggcacagtct tcactaccgt agaagacctt ggctccaaga tactcctcac      300

ctgctccttg aatgacagcg ccacagaggt cacagggcac cgctggctga aggggggcgt      360

ggtgctgaag gaggacgcgc tgcccggcca gaaaacggag ttcaaggtgg actccgacga      420

ccagtgggga gagtactcct gcgtcttcct ccccgagccc atgggcacgg ccaacatcca      480

gctccacggg cctcccagag tgaaggctgt gaagtcgtca gaacacatca acgaggggga      540

gacggccatg ctggtctgca agtcagagtc cgtgccacct gtcactgact gggcctggta      600

caagatcact gactctgagg acaaggccct catgaacggc tccgagagca ggttcttcgt      660

gagttcctcg cagggccggt cagagctaca cattgagaac ctgaacatgg aggccgaccc      720

cggccagtac cggtgcaacg gcaccagctc caagggctcc gaccaggcca tcatcacgct      780

ccgcgtgcgc agccacctgg ccgccctctg gcccttcctg ggcatcgtgg ctgaggtgct      840

ggtgctggtc accatcatct tcatctacga gaagcgccgg aagcccgagg acgtcctgga      900

tgatgacgac gccggctctg cacccctgaa gagcagcggg cagcaccaga atgacaaagg      960

caagaacgtc cgccagagga actcttcctg aggcaggtgg cccgaggacg ctccctgctc     1020

cacgtctgcg ccgccgccgg agtccactcc cagtgcttgc aagattccaa gttctcacct     1080

cttaaagaaa acccaccccg tagattccca tcatacactt ccttcttttt taaaaaagtt     1140

gggttttctc cattcaggat tctgttcctt aggttttttt ccttctgaag tgtttcacga     1200

gagcccggga gctgctgccc tgcggccccg tctgtggctt tcagcctctg ggtctgagtc     1260

atggccgggt gggcggcaca gccttctcca ctggccggag tcagtgccag gtccttgccc     1320

tttgtggaaa gtcacaggtc acacgagggg ccccgtgtcc tgcctgtctg aagccaatgc     1380

tgtctggttg cgccattttt gtgcttttat gtttaatttt atgagggcca cgggtctgtg     1440

ttcgactcag cctcagggac gactctgacc tcttggccac agaggactca cttgcccaca     1500

ccgagggcga ccccgtcaca gcctcaagtc actcccaagc cccctccttg tctgtgcatc     1560

cgggggcagc tctggagggg gtttgctggg gaactggcgc catcgccggg actccagaac     1620

cgcagaagcc tccccagctc acccctggag gacggccggc tctctatagc accagggctc     1680

acgtgggaac ccccctccca cccaccgcca caataaagat cgcccccacc tccaccctca     1740

aaaaaaaaaa aaaaaaaaa                                                  1759


<210> 170
<211> 269
<212> PRT
<213> Homo sapiens

<400> 170
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr 
        35                  40                  45              


Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu 
    50                  55                  60                  


Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp 
65                  70                  75                  80  


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
                85                  90                  95      


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
            100                 105                 110         


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
        115                 120                 125             


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
    130                 135                 140                 


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
145                 150                 155                 160 


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
                165                 170                 175     


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
            180                 185                 190         


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
        195                 200                 205             


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
    210                 215                 220                 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
225                 230                 235                 240 


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
                245                 250                 255     


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
            260                 265                 


<210> 171
<211> 1814
<212> DNA
<213> Homo sapiens

<400> 171
cccgccagtg tagccacatt cctgcccctt tccagttagc ccttcgcgtt cggcttagtc       60

tgcggtcctc ttgcattgcg actccgagtt taacttccaa cacacacttt caacctccaa      120

gagacgcccc cacctgtgtc gccccaatag cgacttttct caccgtggtc gccgcggaac      180

ttcaagggtc cttcctaccc gcgttgctga gagtctgggt ttacgcgtca cctcgggcgg      240

gacccgatcc tccgctcctg aggcccccac aatgaagcag tcggacgcgt ctccccaaga      300

aagccggcac agtcttcact accgtagaag accttggctc caagatactc ctcacctgct      360

ccttgaatga cagcgccaca gaggtcacag ggcaccgctg gctgaagggg ggcgtggtgc      420

tgaaggagga cgcgctgccc ggccagaaaa cggagttcaa ggtggactcc gacgaccagt      480

ggggagagta ctcctgcgtc ttcctccccg agcccatggg cacggccaac atccagctcc      540

acgggcctcc cagagtgaag gctgtgaagt cgtcagaaca catcaacgag ggggagacgg      600

ccatgctggt ctgcaagtca gagtccgtgc cacctgtcac tgactgggcc tggtacaaga      660

tcactgactc tgaggacaag gccctcatga acggctccga gagcaggttc ttcgtgagtt      720

cctcgcaggg ccggtcagag ctacacattg agaacctgaa catggaggcc gaccccggcc      780

agtaccggtg caacggcacc agctccaagg gctccgacca ggccatcatc acgctccgcg      840

tgcgcagcca cctggccgcc ctctggccct tcctgggcat cgtggctgag gtgctggtgc      900

tggtcaccat catcttcatc tacgagaagc gccggaagcc cgaggacgtc ctggatgatg      960

acgacgccgg ctctgcaccc ctgaagagca gcgggcagca ccagaatgac aaaggcaaga     1020

acgtccgcca gaggaactct tcctgaggca ggtggcccga ggacgctccc tgctccacgt     1080

ctgcgccgcc gccggagtcc actcccagtg cttgcaagat tccaagttct cacctcttaa     1140

agaaaaccca ccccgtagat tcccatcata cacttccttc ttttttaaaa aagttgggtt     1200

ttctccattc aggattctgt tccttaggtt tttttccttc tgaagtgttt cacgagagcc     1260

cgggagctgc tgccctgcgg ccccgtctgt ggctttcagc ctctgggtct gagtcatggc     1320

cgggtgggcg gcacagcctt ctccactggc cggagtcagt gccaggtcct tgccctttgt     1380

ggaaagtcac aggtcacacg aggggccccg tgtcctgcct gtctgaagcc aatgctgtct     1440

ggttgcgcca tttttgtgct tttatgttta attttatgag ggccacgggt ctgtgttcga     1500

ctcagcctca gggacgactc tgacctcttg gccacagagg actcacttgc ccacaccgag     1560

ggcgaccccg tcacagcctc aagtcactcc caagccccct ccttgtctgt gcatccgggg     1620

gcagctctgg agggggtttg ctggggaact ggcgccatcg ccgggactcc agaaccgcag     1680

aagcctcccc agctcacccc tggaggacgg ccggctctct atagcaccag ggctcacgtg     1740

ggaacccccc tcccacccac cgccacaata aagatcgccc ccacctccac cctcaaaaaa     1800

aaaaaaaaaa aaaa                                                       1814


<210> 172
<211> 176
<212> PRT
<213> Homo sapiens

<400> 172
Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala 
1               5                   10                  15      


Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val 
            20                  25                  30          


Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys 
        35                  40                  45              


Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg 
    50                  55                  60                  


Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn 
65                  70                  75                  80  


Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser 
                85                  90                  95      


Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His 
            100                 105                 110         


Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val 
        115                 120                 125             


Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp 
    130                 135                 140                 


Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly 
145                 150                 155                 160 


Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
                165                 170                 175     


<210> 173
<211> 1657
<212> DNA
<213> Homo sapiens

<400> 173
cccgccagtg tagccacatt cctgcccctt tccagttagc ccttcgcgtt cggcttagtc       60

tgcggtcctc ttgcattgcg actccgagtt taacttccaa cacacacttt caacctccaa      120

gagacgcccc cacctgtgtc gccccaatag cgacttttct caccgtggtc gccgcggaac      180

ttcaagggtc cttcctaccc gcgttgctga gagtctgggt ttacgcgtca cctcgggcgg      240

gacccgatcc tccgctcctg aggcccccac aatgaagcag tcggacgcgt ctccccaaga      300

aagggtggac tccgacgacc agtggggaga gtactcctgc gtcttcctcc ccgagcccat      360

gggcacggcc aacatccagc tccacgggcc tcccagagtg aaggctgtga agtcgtcaga      420

acacatcaac gagggggaga cggccatgct ggtctgcaag tcagagtccg tgccacctgt      480

cactgactgg gcctggtaca agatcactga ctctgaggac aaggccctca tgaacggctc      540

cgagagcagg ttcttcgtga gttcctcgca gggccggtca gagctacaca ttgagaacct      600

gaacatggag gccgaccccg gccagtaccg gtgcaacggc accagctcca agggctccga      660

ccaggccatc atcacgctcc gcgtgcgcag ccacctggcc gccctctggc ccttcctggg      720

catcgtggct gaggtgctgg tgctggtcac catcatcttc atctacgaga agcgccggaa      780

gcccgaggac gtcctggatg atgacgacgc cggctctgca cccctgaaga gcagcgggca      840

gcaccagaat gacaaaggca agaacgtccg ccagaggaac tcttcctgag gcaggtggcc      900

cgaggacgct ccctgctcca cgtctgcgcc gccgccggag tccactccca gtgcttgcaa      960

gattccaagt tctcacctct taaagaaaac ccaccccgta gattcccatc atacacttcc     1020

ttctttttta aaaaagttgg gttttctcca ttcaggattc tgttccttag gtttttttcc     1080

ttctgaagtg tttcacgaga gcccgggagc tgctgccctg cggccccgtc tgtggctttc     1140

agcctctggg tctgagtcat ggccgggtgg gcggcacagc cttctccact ggccggagtc     1200

agtgccaggt ccttgccctt tgtggaaagt cacaggtcac acgaggggcc ccgtgtcctg     1260

cctgtctgaa gccaatgctg tctggttgcg ccatttttgt gcttttatgt ttaattttat     1320

gagggccacg ggtctgtgtt cgactcagcc tcagggacga ctctgacctc ttggccacag     1380

aggactcact tgcccacacc gagggcgacc ccgtcacagc ctcaagtcac tcccaagccc     1440

cctccttgtc tgtgcatccg ggggcagctc tggagggggt ttgctgggga actggcgcca     1500

tcgccgggac tccagaaccg cagaagcctc cccagctcac ccctggagga cggccggctc     1560

tctatagcac cagggctcac gtgggaaccc ccctcccacc caccgccaca ataaagatcg     1620

cccccacctc caccctcaaa aaaaaaaaaa aaaaaaa                              1657


<210> 174
<211> 205
<212> PRT
<213> Homo sapiens

<400> 174
Met Lys Gln Ser Asp Ala Ser Pro Gln Glu Arg Val Asp Ser Asp Asp 
1               5                   10                  15      


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
            20                  25                  30          


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
        35                  40                  45              


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
    50                  55                  60                  


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
65                  70                  75                  80  


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
                85                  90                  95      


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
            100                 105                 110         


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
        115                 120                 125             


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
    130                 135                 140                 


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
145                 150                 155                 160 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
                165                 170                 175     


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
            180                 185                 190         


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
        195                 200                 205 


<210> 175
<211> 1734
<212> DNA
<213> Homo sapiens

<400> 175
acgcacgcac gtctctcgct ttcgcatact taaggcgtct gttctcggca gcggcacagc       60

gaggtcggca gcggcacagc gaggtcggca gcggcacagc gaggtcggca gcggcacagc      120

gaggtcggca gcggcagcga ggtcggcagc ggcacagcga ggtcggcagc ggcagcgagg      180

tcggcagcgg cgcgcgctgt gctcttccgc ggactctgaa tcatggcgac cacggccacg      240

atggcgacct cgggctcggc gcgaaagcgg ctgctcaaag aggaagacat gactaaagtg      300

gaattcgaga ccagcgagga ggtggatgtg acccccacgt tcgacaccat gggcctgcgg      360

gaggacctgc tgcggggcat ctacgcttac ggttttgaaa aaccatcagc aatccagcaa      420

cgagcaatca agcagatcat caaagggaga gatgtcatcg cacagtctca gtccggcaca      480

ggaaaaacag ccaccttcag tatctcagtc ctccagtgtt tggatattca ggttcgtgaa      540

actcaagctt tgatcttggc tcccacaaga gagttggctg tgcagatcca gaaggggctg      600

cttgctctcg gtgactacat gaatgtccag tgccatgcct gcattggagg caccaatgtt      660

ggcgaggaca tcaggaagct ggattacgga cagcatgttg tcgcgggcac tccagggcgt      720

gtttttgata tgattcgtcg cagaagccta aggacacgtg ctatcaaaat gttggttttg      780

gatgaagctg atgaaatgtt gaataaaggt ttcaaagagc agatttacga tgtatacagg      840

tacctgcctc cagccacaca ggtggttctc atcagtgcca cgctgccaca cgagattctg      900

gagatgacca acaagttcat gaccgaccca atccgcatct tggtgaaacg tgatgaattg      960

actctggaag gcatcaagca atttttcgtg gcagtggaga gggaagagtg gaaatttgac     1020

actctgtgtg acctctacga cacactgacc atcactcagg cggtcatctt ctgcaacacc     1080

aaaagaaagg tggactggct gacggagaaa atgagggaag ccaacttcac tgtatcctca     1140

atgcatggag acatgcccca gaaagagcgg gagtccatca tgaaggagtt ccggtcgggc     1200

gccagccgag tgcttatttc tacagatgtc tgggccaggg ggttggatgt ccctcaggtg     1260

tccctcatca ttaactatga tctccctaat aacagagaat tgtacataca cagaattggg     1320

agatcaggtc gatacggccg gaagggtgtg gccattaact ttgtaaagaa tgacgacatc     1380

cgcatcctca gagatatcga gcagtactat tccactcaga ttgatgagat gccgatgaac     1440

gttgctgatc ttatctgaag cagcagatca gtgggatgag ggagactgtt cacctgctgt     1500

gtactcctgt ttggaagtat ttagatccag attctactta atggggttta tatggacttt     1560

cttctcataa atggcctgcc gtctcccttc ctttgaagag gatatgggga ttctgctctc     1620

ttttcttatt tacatgtaaa taatacattg ttctaagtct ttttcattaa aaatttaaaa     1680

cttttcccat aaactctata cttctaaggt gccaccacct tctctagtaa ctta           1734


<210> 176
<211> 411
<212> PRT
<213> Homo sapiens

<400> 176
Met Ala Thr Thr Ala Thr Met Ala Thr Ser Gly Ser Ala Arg Lys Arg 
1               5                   10                  15      


Leu Leu Lys Glu Glu Asp Met Thr Lys Val Glu Phe Glu Thr Ser Glu 
            20                  25                  30          


Glu Val Asp Val Thr Pro Thr Phe Asp Thr Met Gly Leu Arg Glu Asp 
        35                  40                  45              


Leu Leu Arg Gly Ile Tyr Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile 
    50                  55                  60                  


Gln Gln Arg Ala Ile Lys Gln Ile Ile Lys Gly Arg Asp Val Ile Ala 
65                  70                  75                  80  


Gln Ser Gln Ser Gly Thr Gly Lys Thr Ala Thr Phe Ser Ile Ser Val 
                85                  90                  95      


Leu Gln Cys Leu Asp Ile Gln Val Arg Glu Thr Gln Ala Leu Ile Leu 
            100                 105                 110         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Gln Lys Gly Leu Leu Ala 
        115                 120                 125             


Leu Gly Asp Tyr Met Asn Val Gln Cys His Ala Cys Ile Gly Gly Thr 
    130                 135                 140                 


Asn Val Gly Glu Asp Ile Arg Lys Leu Asp Tyr Gly Gln His Val Val 
145                 150                 155                 160 


Ala Gly Thr Pro Gly Arg Val Phe Asp Met Ile Arg Arg Arg Ser Leu 
                165                 170                 175     


Arg Thr Arg Ala Ile Lys Met Leu Val Leu Asp Glu Ala Asp Glu Met 
            180                 185                 190         


Leu Asn Lys Gly Phe Lys Glu Gln Ile Tyr Asp Val Tyr Arg Tyr Leu 
        195                 200                 205             


Pro Pro Ala Thr Gln Val Val Leu Ile Ser Ala Thr Leu Pro His Glu 
    210                 215                 220                 


Ile Leu Glu Met Thr Asn Lys Phe Met Thr Asp Pro Ile Arg Ile Leu 
225                 230                 235                 240 


Val Lys Arg Asp Glu Leu Thr Leu Glu Gly Ile Lys Gln Phe Phe Val 
                245                 250                 255     


Ala Val Glu Arg Glu Glu Trp Lys Phe Asp Thr Leu Cys Asp Leu Tyr 
            260                 265                 270         


Asp Thr Leu Thr Ile Thr Gln Ala Val Ile Phe Cys Asn Thr Lys Arg 
        275                 280                 285             


Lys Val Asp Trp Leu Thr Glu Lys Met Arg Glu Ala Asn Phe Thr Val 
    290                 295                 300                 


Ser Ser Met His Gly Asp Met Pro Gln Lys Glu Arg Glu Ser Ile Met 
305                 310                 315                 320 


Lys Glu Phe Arg Ser Gly Ala Ser Arg Val Leu Ile Ser Thr Asp Val 
                325                 330                 335     


Trp Ala Arg Gly Leu Asp Val Pro Gln Val Ser Leu Ile Ile Asn Tyr 
            340                 345                 350         


Asp Leu Pro Asn Asn Arg Glu Leu Tyr Ile His Arg Ile Gly Arg Ser 
        355                 360                 365             


Gly Arg Tyr Gly Arg Lys Gly Val Ala Ile Asn Phe Val Lys Asn Asp 
    370                 375                 380                 


Asp Ile Arg Ile Leu Arg Asp Ile Glu Gln Tyr Tyr Ser Thr Gln Ile 
385                 390                 395                 400 


Asp Glu Met Pro Met Asn Val Ala Asp Leu Ile 
                405                 410     


<210> 177
<211> 3466
<212> DNA
<213> Homo sapiens

<400> 177
aattacggcc ggattccgga gtcctttcca gctccctctt cggccgggtt tcccgccgaa       60

tacaaaggcg cactgtgaac tggctctttc tttccgccaa tcatttccgc cagccattca      120

tcaccgattt tcttcatctt cccctccctc ttccgtcccg cagtccccga cctgttagct      180

ctcggttagt taagggactc gggtccttcc gaactgcgca tgcgccaccg cgtctgcagg      240

gggagaagcg ggcaggggcg caggcgcagt agtgtgatcc cctggccagt ccctaagcac      300

gtgggttggg ttgtcctgct tggctgcgga gggagtggaa cctcgatatt ggtggtgtcc      360

atcgtgggca gcggactaat aaaggccatg gcgccagcag aaatcctgaa cgggaaggag      420

atctccgcgc aaataagggc gagactgaaa aatcaagtca ctcagttgaa ggagcaagta      480

cctggtttca caccacgcct ggcaatatta caggttggca acagagatga ttccaatctt      540

tatataaatg tgaagctgaa ggctgctgaa gagattggga tcaaagccac tcacattaag      600

ttaccaagaa caaccacaga atctgaggtg atgaagtaca ttacatcttt gaatgaagac      660

tctactgtac atgggttctt agtgcagcta cctttagatt cagagaattc cattaacact      720

gaagaagtga tcaatgctat tgcacccgag aaggatgtgg atggattgac tagcatcaat      780

gctgggaaac ttgctagagg tgacctcaat gactgtttca ttccttgtac gcctaaggga      840

tgcttggaac tcatcaaaga gacaggggtg ccgattgccg gaaggcatgc tgtggtggtt      900

gggcgcagta aaatagttgg ggccccgatg catgacttgc ttctgtggaa caatgccaca      960

gtgaccacct gccactccaa gactgcccat ctggatgagg aggtaaataa aggtgacatc     1020

ctggtggttg caactggtca gcctgaaatg gttaaagggg agtggatcaa acctggggca     1080

atagtcatcg actgtggaat caattatgtc ccagatgata aaaaaccaaa tgggagaaaa     1140

gttgtgggtg atgtggcata cgacgaggcc aaagagaggg cgagcttcat cactcctgtt     1200

cctggcggcg tagggcccat gacagttgca atgctcatgc agagcacagt agagagtgcc     1260

aagcgtttcc tggagaaatt taagccagga aagtggatga ttcagtataa caaccttaac     1320

ctcaagacac ctgttccaag tgacattgat atatcacgat cttgtaaacc gaagcccatt     1380

ggtaagctgg ctcgagaaat tggtctgctg tctgaagagg tagaattata tggtgaaaca     1440

aaggccaaag ttctgctgtc agcactagaa cgcctgaagc accggcctga tgggaaatac     1500

gtggtggtga ctggaataac tccaacaccc ctgggagaag ggaaaagcac aactacaatc     1560

gggctagtgc aagcccttgg tgcccatctc taccagaatg tctttgcgtg tgtgcgacag     1620

ccttctcagg gccccacctt tggaataaaa ggtggcgctg caggaggcgg ctactcccag     1680

gtcattccta tggaagagtt taatctccac ctcacaggtg acatccatgc catcactgca     1740

gctaataacc tcgttgctgc ggccattgat gctcggatat ttcatgaact gacccagaca     1800

gacaaggctc tctttaatcg tttggtgcca tcagtaaatg gagtgagaag gttctctgac     1860

atccaaatcc gaaggttaaa gagactaggc attgaaaaga ctgaccctac cacactgaca     1920

gatgaagaga taaacagatt tgcaagattg gacattgatc cagaaaccat aacttggcaa     1980

agagtgttgg ataccaatga tagattcctg aggaagatca cgattggaca ggctccaacg     2040

gagaagggtc acacacggac ggcccagttt gatatctctg tggccagtga aattatggct     2100

gtcctggctc tcaccacttc tctagaagac atgagagaga gactgggcaa aatggtggtg     2160

gcatccagta agaaaggaga gcccgtcagt gccgaagatc tgggggtgag tggtgcactg     2220

acagtgctta tgaaggacgc aatcaagccc aatctcatgc agacactgga gggcactcca     2280

gtgtttgtcc atgctggccc gtttgccaac atcgcacatg gcaattcctc catcattgca     2340

gaccggatcg cactcaagct tgttggccca gaagggtttg tagtgacgga agcaggattt     2400

ggagcagaca ttggaatgga aaagtttttt aacatcaaat gccggtattc cggcctctgc     2460

ccccacgtgg tggtgcttgt tgccactgtc agggctctca agatgcacgg gggcggcccc     2520

acggtcactg ctggactgcc tcttcccaag gcttacatac aggagaacct ggagctggtt     2580

gaaaaaggct tcagtaactt gaagaaacaa attgaaaatg ccagaatgtt tggaattcca     2640

gtagtagtgg ccgtgaatgc attcaagacg gatacagagt ctgagctgga cctcatcagc     2700

cgcctttcca gagaacatgg ggcttttgat gccgtgaagt gcactcactg ggcagaaggg     2760

ggcaagggtg ccttagccct ggctcaggcc gtccagagag cagcacaagc acccagcagc     2820

ttccagctcc tttatgacct caagctccca gttgaggata aaatcaggat cattgcacag     2880

aagatctatg gagcagatga cattgaatta cttcccgaag ctcaacacaa agctgaagtc     2940

tacacgaagc agggctttgg gaatctcccc atctgcatgg ctaaaacaca cttgtctttg     3000

tctcacaacc cagagcaaaa aggtgtccct acaggcttca ttctgcccat tcgcgacatc     3060

cgcgccagcg ttggggctgg ttttctgtac cccttagtag gaacgatgag cacaatgcct     3120

ggactcccca cccggccctg tttttatgat attgatttgg accctgaaac agaacaggtg     3180

aatggattat tctaaacaga tcaccatcca tcttcaagaa gctactttga aagtctggcc     3240

agtgtctatt caggcccact gggagttagg aagtataagt aagccaagag aagtcagccc     3300

ctgcccagaa gatctgaaac taatagtagg agtttcccca gaagtcattt tcagccttaa     3360

ttctcatcat gtataaatta acataaatca tgcatgtctg tttactttag tgacgttcca     3420

cagaataaaa ggaaacaagt ttgccatcaa aaaaaaaaaa aaaaaa                    3466


<210> 178
<211> 935
<212> PRT
<213> Homo sapiens

<400> 178
Met Ala Pro Ala Glu Ile Leu Asn Gly Lys Glu Ile Ser Ala Gln Ile 
1               5                   10                  15      


Arg Ala Arg Leu Lys Asn Gln Val Thr Gln Leu Lys Glu Gln Val Pro 
            20                  25                  30          


Gly Phe Thr Pro Arg Leu Ala Ile Leu Gln Val Gly Asn Arg Asp Asp 
        35                  40                  45              


Ser Asn Leu Tyr Ile Asn Val Lys Leu Lys Ala Ala Glu Glu Ile Gly 
    50                  55                  60                  


Ile Lys Ala Thr His Ile Lys Leu Pro Arg Thr Thr Thr Glu Ser Glu 
65                  70                  75                  80  


Val Met Lys Tyr Ile Thr Ser Leu Asn Glu Asp Ser Thr Val His Gly 
                85                  90                  95      


Phe Leu Val Gln Leu Pro Leu Asp Ser Glu Asn Ser Ile Asn Thr Glu 
            100                 105                 110         


Glu Val Ile Asn Ala Ile Ala Pro Glu Lys Asp Val Asp Gly Leu Thr 
        115                 120                 125             


Ser Ile Asn Ala Gly Lys Leu Ala Arg Gly Asp Leu Asn Asp Cys Phe 
    130                 135                 140                 


Ile Pro Cys Thr Pro Lys Gly Cys Leu Glu Leu Ile Lys Glu Thr Gly 
145                 150                 155                 160 


Val Pro Ile Ala Gly Arg His Ala Val Val Val Gly Arg Ser Lys Ile 
                165                 170                 175     


Val Gly Ala Pro Met His Asp Leu Leu Leu Trp Asn Asn Ala Thr Val 
            180                 185                 190         


Thr Thr Cys His Ser Lys Thr Ala His Leu Asp Glu Glu Val Asn Lys 
        195                 200                 205             


Gly Asp Ile Leu Val Val Ala Thr Gly Gln Pro Glu Met Val Lys Gly 
    210                 215                 220                 


Glu Trp Ile Lys Pro Gly Ala Ile Val Ile Asp Cys Gly Ile Asn Tyr 
225                 230                 235                 240 


Val Pro Asp Asp Lys Lys Pro Asn Gly Arg Lys Val Val Gly Asp Val 
                245                 250                 255     


Ala Tyr Asp Glu Ala Lys Glu Arg Ala Ser Phe Ile Thr Pro Val Pro 
            260                 265                 270         


Gly Gly Val Gly Pro Met Thr Val Ala Met Leu Met Gln Ser Thr Val 
        275                 280                 285             


Glu Ser Ala Lys Arg Phe Leu Glu Lys Phe Lys Pro Gly Lys Trp Met 
    290                 295                 300                 


Ile Gln Tyr Asn Asn Leu Asn Leu Lys Thr Pro Val Pro Ser Asp Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Ser Cys Lys Pro Lys Pro Ile Gly Lys Leu Ala Arg 
                325                 330                 335     


Glu Ile Gly Leu Leu Ser Glu Glu Val Glu Leu Tyr Gly Glu Thr Lys 
            340                 345                 350         


Ala Lys Val Leu Leu Ser Ala Leu Glu Arg Leu Lys His Arg Pro Asp 
        355                 360                 365             


Gly Lys Tyr Val Val Val Thr Gly Ile Thr Pro Thr Pro Leu Gly Glu 
    370                 375                 380                 


Gly Lys Ser Thr Thr Thr Ile Gly Leu Val Gln Ala Leu Gly Ala His 
385                 390                 395                 400 


Leu Tyr Gln Asn Val Phe Ala Cys Val Arg Gln Pro Ser Gln Gly Pro 
                405                 410                 415     


Thr Phe Gly Ile Lys Gly Gly Ala Ala Gly Gly Gly Tyr Ser Gln Val 
            420                 425                 430         


Ile Pro Met Glu Glu Phe Asn Leu His Leu Thr Gly Asp Ile His Ala 
        435                 440                 445             


Ile Thr Ala Ala Asn Asn Leu Val Ala Ala Ala Ile Asp Ala Arg Ile 
    450                 455                 460                 


Phe His Glu Leu Thr Gln Thr Asp Lys Ala Leu Phe Asn Arg Leu Val 
465                 470                 475                 480 


Pro Ser Val Asn Gly Val Arg Arg Phe Ser Asp Ile Gln Ile Arg Arg 
                485                 490                 495     


Leu Lys Arg Leu Gly Ile Glu Lys Thr Asp Pro Thr Thr Leu Thr Asp 
            500                 505                 510         


Glu Glu Ile Asn Arg Phe Ala Arg Leu Asp Ile Asp Pro Glu Thr Ile 
        515                 520                 525             


Thr Trp Gln Arg Val Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile 
    530                 535                 540                 


Thr Ile Gly Gln Ala Pro Thr Glu Lys Gly His Thr Arg Thr Ala Gln 
545                 550                 555                 560 


Phe Asp Ile Ser Val Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr 
                565                 570                 575     


Thr Ser Leu Glu Asp Met Arg Glu Arg Leu Gly Lys Met Val Val Ala 
            580                 585                 590         


Ser Ser Lys Lys Gly Glu Pro Val Ser Ala Glu Asp Leu Gly Val Ser 
        595                 600                 605             


Gly Ala Leu Thr Val Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met 
    610                 615                 620                 


Gln Thr Leu Glu Gly Thr Pro Val Phe Val His Ala Gly Pro Phe Ala 
625                 630                 635                 640 


Asn Ile Ala His Gly Asn Ser Ser Ile Ile Ala Asp Arg Ile Ala Leu 
                645                 650                 655     


Lys Leu Val Gly Pro Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly 
            660                 665                 670         


Ala Asp Ile Gly Met Glu Lys Phe Phe Asn Ile Lys Cys Arg Tyr Ser 
        675                 680                 685             


Gly Leu Cys Pro His Val Val Val Leu Val Ala Thr Val Arg Ala Leu 
    690                 695                 700                 


Lys Met His Gly Gly Gly Pro Thr Val Thr Ala Gly Leu Pro Leu Pro 
705                 710                 715                 720 


Lys Ala Tyr Ile Gln Glu Asn Leu Glu Leu Val Glu Lys Gly Phe Ser 
                725                 730                 735     


Asn Leu Lys Lys Gln Ile Glu Asn Ala Arg Met Phe Gly Ile Pro Val 
            740                 745                 750         


Val Val Ala Val Asn Ala Phe Lys Thr Asp Thr Glu Ser Glu Leu Asp 
        755                 760                 765             


Leu Ile Ser Arg Leu Ser Arg Glu His Gly Ala Phe Asp Ala Val Lys 
    770                 775                 780                 


Cys Thr His Trp Ala Glu Gly Gly Lys Gly Ala Leu Ala Leu Ala Gln 
785                 790                 795                 800 


Ala Val Gln Arg Ala Ala Gln Ala Pro Ser Ser Phe Gln Leu Leu Tyr 
                805                 810                 815     


Asp Leu Lys Leu Pro Val Glu Asp Lys Ile Arg Ile Ile Ala Gln Lys 
            820                 825                 830         


Ile Tyr Gly Ala Asp Asp Ile Glu Leu Leu Pro Glu Ala Gln His Lys 
        835                 840                 845             


Ala Glu Val Tyr Thr Lys Gln Gly Phe Gly Asn Leu Pro Ile Cys Met 
    850                 855                 860                 


Ala Lys Thr His Leu Ser Leu Ser His Asn Pro Glu Gln Lys Gly Val 
865                 870                 875                 880 


Pro Thr Gly Phe Ile Leu Pro Ile Arg Asp Ile Arg Ala Ser Val Gly 
                885                 890                 895     


Ala Gly Phe Leu Tyr Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly 
            900                 905                 910         


Leu Pro Thr Arg Pro Cys Phe Tyr Asp Ile Asp Leu Asp Pro Glu Thr 
        915                 920                 925             


Glu Gln Val Asn Gly Leu Phe 
    930                 935 


<210> 179
<211> 2423
<212> DNA
<213> Homo sapiens

<400> 179
acccgcgctc gtacgtgcgc ctccgccggc agctcctgac tcatcggggg ctccgggtca       60

catgcgcccg cgcggcccta taggcgcctc ctccgcccgc cgcccgggag ccgcagccgc      120

cgccgccact gccactcccg ctctctcagc gccgccgtcg ccaccgccac cgccaccgcc      180

actaccaccg tctgagtctg cagtcccgag atcccagcca tcatgtccat agagaagatc      240

tgggcccggg agatcctgga ctcccgcggg aaccccacag tggaggtgga tctctatact      300

gccaaaggtc ttttccgggc tgcagtgccc agtggagcct ctacgggcat ctatgaggcc      360

ctggagctga gggatggaga caaacagcgt tacttaggca aaggtgtcct gaaggcagtg      420

gaccacatca actccaccat cgcgccagcc ctcatcagct caggtctctc tgtggtggag      480

caagagaaac tggacaacct gatgctggag ttggatggga ctgagaacaa atccaagttt      540

ggggccaatg ccatcctggg tgtgtctctg gccgtgtgta aggcaggggc agctgagcgg      600

gaactgcccc tgtatcgcca cattgctcag ctggccggga actcagacct catcctgcct      660

gtgccggcct tcaacgtgat caatggtggc tctcatgctg gcaacaagct ggccatgcag      720

gagttcatga tcctcccagt gggagctgag agctttcggg atgccatgcg actaggtgca      780

gaggtctacc atacactcaa gggagtcatc aaggacaaat acggcaagga tgccaccaat      840

gtgggggatg aaggtggctt tgcccccaat atcctggaga acagtgaagc cttggagctg      900

gtgaaggaag ccatcgacaa ggctggctac acggaaaaga tcgttattgg catggatgtt      960

gctgcctcag agttttatcg tgatggcaaa tatgacttgg acttcaagtc tcccactgat     1020

ccttcccgat acatcactgg ggaccagctg ggggcactct accaggactt tgtcagggac     1080

tatcctgtgg tctccattga ggacccattt gaccaggatg attgggctgc ctggtccaag     1140

ttcacagcca atgtagggat ccagattgtg ggtgatgacc tgacagtgac caacccaaaa     1200

cgtattgagc gggcagtgga agaaaaggcc tgcaactgtc tgctgctcaa ggtcaaccag     1260

atcggctcgg tcactgaagc catccaagcg tgcaagctgg cccaggagaa tggctggggg     1320

gtcatggtga gtcatcgctc aggagagact gaggacacat tcattgctga cctggtggtg     1380

gggctgtgca caggccagat caagactggt gccccgtgcc gttctgaacg tctggctaaa     1440

tacaaccagc tcatgagaat tgaggaagag ctgggggatg aagctcgctt tgccggacat     1500

aacttccgta atcccagtgt gctgtgattc ctctgcttgc ctggagacgt ggaacctctg     1560

tctcatcctc ctggaacctt gctgtcctga tctgtgatag ttcaccccct gagatcccct     1620

gagccccagg gtgcccagaa cttccctgat tgacctgctc cgctgctcct tggcttacct     1680

gacctcttgc tgtctctgct cgccctcctt tctgtgccct actcattggg gttccgcact     1740

ttccacttct tcctttctct ttctctcttc cctcagaaac tagaaatgtg aatgaggatt     1800

attataaaag ggggtccgtg gaagaatgat cagcatctgt gatgggagcg tcagggttgg     1860

tgtgctgagg tgttagagag ggaccatgtg tcacttgtgc tttgctcttg tcccacgtgt     1920

cttccacttt gcatatgagc cgtgaactgt gcatagtgct gggatggagg ggagtgttgg     1980

gcatgtgatc acgcctggct aataaggctt tagtgtattt atttatttat ttattttatt     2040

tgtttttcat tcatcccatt aatcatttcc ccataactca atggcctaaa actggcctga     2100

cttgggggaa cgatgtgtct gtatttcatg tggctgtaga tcccaagatg actggggtgg     2160

gaggtcttgc tagaatggga agggtcatag aaagggcctt gacatcagtt cctttgtgtg     2220

tactcactga agcctgcgtt ggtccagagc ggaggctgtg tgcctggggg agttttcctc     2280

tatacatctc tccccaaccc taggttccct gttcttcctc cagctgcacc agagcaacct     2340

ctcactcccc atgccacgtt ccacagttgc caccacctct gtggcattga aatgagcacc     2400

tccattaaag tctgaatcag tgc                                             2423


<210> 180
<211> 434
<212> PRT
<213> Homo sapiens

<400> 180
Met Ser Ile Glu Lys Ile Trp Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gln Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Asp His Ile Asn Ser Thr Ile Ala Pro Ala Leu Ile Ser Ser 
65                  70                  75                  80  


Gly Leu Ser Val Val Glu Gln Glu Lys Leu Asp Asn Leu Met Leu Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Arg Glu Leu 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Gln Leu Ala Gly Asn Ser Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Glu 
                165                 170                 175     


Ser Phe Arg Asp Ala Met Arg Leu Gly Ala Glu Val Tyr His Thr Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Asp Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Ser Glu Ala Leu 
    210                 215                 220                 


Glu Leu Val Lys Glu Ala Ile Asp Lys Ala Gly Tyr Thr Glu Lys Ile 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asp Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Thr Asp Pro Ser Arg Tyr Ile Thr 
            260                 265                 270         


Gly Asp Gln Leu Gly Ala Leu Tyr Gln Asp Phe Val Arg Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Ala Trp 
    290                 295                 300                 


Ser Lys Phe Thr Ala Asn Val Gly Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Glu Arg Ala Val Glu Glu Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ala Ile Gln Ala Cys Lys Leu Ala Gln Glu Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Asp Glu Ala Arg Phe Ala Gly His Asn Phe Arg Asn Pro Ser 
            420                 425                 430         


Val Leu 
        


<210> 181
<211> 628
<212> DNA
<213> Homo sapiens

<400> 181
tgacccactt ccgttacttg ctgcggagga ccgtgggcag ccagggtcgg tgaaggatcc       60

caaaatggct gggcgaaaac ttgctctaaa aaccattgac tgggtagctt ttgcagagat      120

cataccccag aaccaaaagg ccattgctag ttccctgaaa tcctggaatg agaccctcac      180

ctccaggttg gctgctttac ctgagaatcc accagctatc gactgggctt actacaaggc      240

caatgtggcc aaggctggct tggtggatga ctttgagaag aagtttaatg cgctgaaggt      300

tcccgtgcca gaggataaat atactgccca ggtggatgcc gaagaaaaag aagatgtgaa      360

atcttgtgct gagtgggtgt ctctctcaaa ggccaggatt gtagaatatg agaaagagat      420

ggagaagatg aagaacttaa ttccatttga tcagatgacc attgaggact tgaatgaagc      480

tttcccagaa accaaattag acaagaaaaa gtatccctat tggcctcacc aaccaattga      540

gaatttataa aattgagtcc aggaggaagc tctggccctt gtattacaca ttctggacat      600

taaaaataat aattatacag ttaaaaaa                                         628


<210> 182
<211> 161
<212> PRT
<213> Homo sapiens

<400> 182
Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ala Phe 
1               5                   10                  15      


Ala Glu Ile Ile Pro Gln Asn Gln Lys Ala Ile Ala Ser Ser Leu Lys 
            20                  25                  30          


Ser Trp Asn Glu Thr Leu Thr Ser Arg Leu Ala Ala Leu Pro Glu Asn 
        35                  40                  45              


Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Lys Ala Asn Val Ala Lys Ala 
    50                  55                  60                  


Gly Leu Val Asp Asp Phe Glu Lys Lys Phe Asn Ala Leu Lys Val Pro 
65                  70                  75                  80  


Val Pro Glu Asp Lys Tyr Thr Ala Gln Val Asp Ala Glu Glu Lys Glu 
                85                  90                  95      


Asp Val Lys Ser Cys Ala Glu Trp Val Ser Leu Ser Lys Ala Arg Ile 
            100                 105                 110         


Val Glu Tyr Glu Lys Glu Met Glu Lys Met Lys Asn Leu Ile Pro Phe 
        115                 120                 125             


Asp Gln Met Thr Ile Glu Asp Leu Asn Glu Ala Phe Pro Glu Thr Lys 
    130                 135                 140                 


Leu Asp Lys Lys Lys Tyr Pro Tyr Trp Pro His Gln Pro Ile Glu Asn 
145                 150                 155                 160 


Leu 
    


<210> 183
<211> 556
<212> DNA
<213> Homo sapiens

<400> 183
tgacccactt ccgttacttg ctgcggagga ccgtgggcag ccagggtcgg tgaaggatcc       60

caaaatggct gggcgaaaac ttgctctaaa aaccattgac tgggtagctt ttgcagagat      120

cataccccag aaccaaaagg ccattgctag ttccctgaaa tcctggaatg agaccctcac      180

ctccaggttg gctgctttac ctgagaatcc accagctatc gactgggctt actacaaggc      240

caatgtggcc aaggctggct tggtggatga ctttgagaag aaggtgaaat cttgtgctga      300

gtgggtgtct ctctcaaagg ccaggattgt agaatatgag aaagagatgg agaagatgaa      360

gaacttaatt ccatttgatc agatgaccat tgaggacttg aatgaagctt tcccagaaac      420

caaattagac aagaaaaagt atccctattg gcctcaccaa ccaattgaga atttataaaa      480

ttgagtccag gaggaagctc tggcccttgt attacacatt ctggacatta aaaataataa      540

ttatacagtt aaaaaa                                                      556


<210> 184
<211> 137
<212> PRT
<213> Homo sapiens

<400> 184
Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ala Phe 
1               5                   10                  15      


Ala Glu Ile Ile Pro Gln Asn Gln Lys Ala Ile Ala Ser Ser Leu Lys 
            20                  25                  30          


Ser Trp Asn Glu Thr Leu Thr Ser Arg Leu Ala Ala Leu Pro Glu Asn 
        35                  40                  45              


Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Lys Ala Asn Val Ala Lys Ala 
    50                  55                  60                  


Gly Leu Val Asp Asp Phe Glu Lys Lys Val Lys Ser Cys Ala Glu Trp 
65                  70                  75                  80  


Val Ser Leu Ser Lys Ala Arg Ile Val Glu Tyr Glu Lys Glu Met Glu 
                85                  90                  95      


Lys Met Lys Asn Leu Ile Pro Phe Asp Gln Met Thr Ile Glu Asp Leu 
            100                 105                 110         


Asn Glu Ala Phe Pro Glu Thr Lys Leu Asp Lys Lys Lys Tyr Pro Tyr 
        115                 120                 125             


Trp Pro His Gln Pro Ile Glu Asn Leu 
    130                 135         


<210> 185
<211> 2310
<212> DNA
<213> Homo sapiens

<400> 185
gaggaagccc cgccccgcgc agccccgtcc cgccccttcc catcgtgtac ggtcccgcgt       60

ggctgcgcgc ggcgctctgg gagtacgaca tggcgcgcga gctgcgggcg ctgctgctgt      120

ggggccgccg cctgcggcct ttgctgcggg cgccggcgct ggcggccgtg ccgggaggaa      180

aaccaattct gtgtcctcgg aggaccacag cccagttggg ccccaggcga aacccagcct      240

ggagcttgca ggcaggacga ctgttcagca cgcagaccgc cgaggacaag gaggaacccc      300

tgcactcgat tatcagcagc acagagagcg tgcagggttc cacttccaaa catgagttcc      360

aggccgagac aaagaagctt ttggacattg ttgcccggtc cctgtactca gaaaaagagg      420

tgtttatacg ggagctgatc tccaatgcca gcgatgcctt ggaaaaactg cgtcacaaac      480

tggtgtctga cggccaagca ctgccagaaa tggagattca cttgcagacc aatgccgaga      540

aaggcaccat caccatccag gatactggta tcgggatgac acaggaagag ctggtgtcca      600

acctggggac gattgccaga tcggggtcaa aggccttcct ggatgctctg cagaaccagg      660

ctgaggccag cagcaagatc atcggccagt ttggagtggg tttctactca gctttcatgg      720

tggctgacag agtggaggtc tattcccgct cggcagcccc ggggagcctg ggttaccagt      780

ggctttcaga tggttctgga gtgtttgaaa tcgccgaagc ttcgggagtt agaaccggga      840

caaaaatcat catccacctg aaatccgact gcaaggagtt ttccagcgag gcccgggtgc      900

gagatgtggt aacgaagtac agcaacttcg tcagcttccc cttgtacttg aatggaaggc      960

ggatgaacac cttgcaggcc atctggatga tggaccccaa ggatgtccgt gagtggcaac     1020

atgaggagtt ctaccgctac gtcgcgcagg ctcacgacaa gccccgctac accctgcact     1080

ataagacgga cgcaccgctc aacatccgca gcatcttcta cgtgcccgac atgaaaccgt     1140

ccatgtttga tgtgagccgg gagctgggct ccagcgttgc actgtacagc cgcaaagtcc     1200

tcatccagac caaggccacg gacatcctgc ccaagtggct gcgcttcatc cgaggtgtgg     1260

tggacagtga ggacattccc ctgaacctca gccgggagct gctgcaggag agcgcactca     1320

tcaggaaact ccgggacgtt ttacagcaga ggctgatcaa attcttcatt gaccagagta     1380

aaaaagatgc tgagaagtat gcaaagtttt ttgaagatta cggcctgttc atgcgggagg     1440

gcattgtgac cgccaccgag caggaggtca aggaggacat agcaaagctg ctgcgctacg     1500

agtcctcggc gctgccctcc gggcagctaa ccagcctctc agaatacgcc agccgcatgc     1560

gggccggcac ccgcaacatc tactacctgt gcgcccccaa ccgtcacctg gcagagcact     1620

caccctacta tgaggccatg aagaagaaag acacagaggt tctcttctgc tttgagcagt     1680

ttgatgagct caccctgctg caccttcgtg agtttgacaa gaagaagctg atctctgtgg     1740

agacggacat agtcgtggat cactacaagg aggagaagtt tgaggacagg tccccagccg     1800

ccgagtgcct atcagagaag gagacggagg agctcatggc ctggatgaga aatgtgctgg     1860

ggtcgcgtgt caccaacgtg aaggtgaccc tccgactgga cacccaccct gccatggtca     1920

ccgtgctgga gatgggggct gcccgccact tcctgcgcat gcagcagctg gccaagaccc     1980

aggaggagcg cgcacagctc ctgcagccca cgctggagat caaccccagg cacgcgctca     2040

tcaagaagct gaatcagctg cgcgcaagcg agcctggcct ggctcagctg ctggtggatc     2100

agatatacga gaacgccatg attgctgctg gacttgttga cgaccctagg gccatggtgg     2160

gccgcttgaa tgagctgctt gtcaaggccc tggagcgaca ctgacagcca gggggccaga     2220

aggactgaca ccacagatga cagccccacc tccttgagct ttatttacct aaatttaaag     2280

gtatttctta acccgaaaaa aaaaaaaaaa                                      2310


<210> 186
<211> 704
<212> PRT
<213> Homo sapiens

<400> 186
Met Ala Arg Glu Leu Arg Ala Leu Leu Leu Trp Gly Arg Arg Leu Arg 
1               5                   10                  15      


Pro Leu Leu Arg Ala Pro Ala Leu Ala Ala Val Pro Gly Gly Lys Pro 
            20                  25                  30          


Ile Leu Cys Pro Arg Arg Thr Thr Ala Gln Leu Gly Pro Arg Arg Asn 
        35                  40                  45              


Pro Ala Trp Ser Leu Gln Ala Gly Arg Leu Phe Ser Thr Gln Thr Ala 
    50                  55                  60                  


Glu Asp Lys Glu Glu Pro Leu His Ser Ile Ile Ser Ser Thr Glu Ser 
65                  70                  75                  80  


Val Gln Gly Ser Thr Ser Lys His Glu Phe Gln Ala Glu Thr Lys Lys 
                85                  90                  95      


Leu Leu Asp Ile Val Ala Arg Ser Leu Tyr Ser Glu Lys Glu Val Phe 
            100                 105                 110         


Ile Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Glu Lys Leu Arg 
        115                 120                 125             


His Lys Leu Val Ser Asp Gly Gln Ala Leu Pro Glu Met Glu Ile His 
    130                 135                 140                 


Leu Gln Thr Asn Ala Glu Lys Gly Thr Ile Thr Ile Gln Asp Thr Gly 
145                 150                 155                 160 


Ile Gly Met Thr Gln Glu Glu Leu Val Ser Asn Leu Gly Thr Ile Ala 
                165                 170                 175     


Arg Ser Gly Ser Lys Ala Phe Leu Asp Ala Leu Gln Asn Gln Ala Glu 
            180                 185                 190         


Ala Ser Ser Lys Ile Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala 
        195                 200                 205             


Phe Met Val Ala Asp Arg Val Glu Val Tyr Ser Arg Ser Ala Ala Pro 
    210                 215                 220                 


Gly Ser Leu Gly Tyr Gln Trp Leu Ser Asp Gly Ser Gly Val Phe Glu 
225                 230                 235                 240 


Ile Ala Glu Ala Ser Gly Val Arg Thr Gly Thr Lys Ile Ile Ile His 
                245                 250                 255     


Leu Lys Ser Asp Cys Lys Glu Phe Ser Ser Glu Ala Arg Val Arg Asp 
            260                 265                 270         


Val Val Thr Lys Tyr Ser Asn Phe Val Ser Phe Pro Leu Tyr Leu Asn 
        275                 280                 285             


Gly Arg Arg Met Asn Thr Leu Gln Ala Ile Trp Met Met Asp Pro Lys 
    290                 295                 300                 


Asp Val Arg Glu Trp Gln His Glu Glu Phe Tyr Arg Tyr Val Ala Gln 
305                 310                 315                 320 


Ala His Asp Lys Pro Arg Tyr Thr Leu His Tyr Lys Thr Asp Ala Pro 
                325                 330                 335     


Leu Asn Ile Arg Ser Ile Phe Tyr Val Pro Asp Met Lys Pro Ser Met 
            340                 345                 350         


Phe Asp Val Ser Arg Glu Leu Gly Ser Ser Val Ala Leu Tyr Ser Arg 
        355                 360                 365             


Lys Val Leu Ile Gln Thr Lys Ala Thr Asp Ile Leu Pro Lys Trp Leu 
    370                 375                 380                 


Arg Phe Ile Arg Gly Val Val Asp Ser Glu Asp Ile Pro Leu Asn Leu 
385                 390                 395                 400 


Ser Arg Glu Leu Leu Gln Glu Ser Ala Leu Ile Arg Lys Leu Arg Asp 
                405                 410                 415     


Val Leu Gln Gln Arg Leu Ile Lys Phe Phe Ile Asp Gln Ser Lys Lys 
            420                 425                 430         


Asp Ala Glu Lys Tyr Ala Lys Phe Phe Glu Asp Tyr Gly Leu Phe Met 
        435                 440                 445             


Arg Glu Gly Ile Val Thr Ala Thr Glu Gln Glu Val Lys Glu Asp Ile 
    450                 455                 460                 


Ala Lys Leu Leu Arg Tyr Glu Ser Ser Ala Leu Pro Ser Gly Gln Leu 
465                 470                 475                 480 


Thr Ser Leu Ser Glu Tyr Ala Ser Arg Met Arg Ala Gly Thr Arg Asn 
                485                 490                 495     


Ile Tyr Tyr Leu Cys Ala Pro Asn Arg His Leu Ala Glu His Ser Pro 
            500                 505                 510         


Tyr Tyr Glu Ala Met Lys Lys Lys Asp Thr Glu Val Leu Phe Cys Phe 
        515                 520                 525             


Glu Gln Phe Asp Glu Leu Thr Leu Leu His Leu Arg Glu Phe Asp Lys 
    530                 535                 540                 


Lys Lys Leu Ile Ser Val Glu Thr Asp Ile Val Val Asp His Tyr Lys 
545                 550                 555                 560 


Glu Glu Lys Phe Glu Asp Arg Ser Pro Ala Ala Glu Cys Leu Ser Glu 
                565                 570                 575     


Lys Glu Thr Glu Glu Leu Met Ala Trp Met Arg Asn Val Leu Gly Ser 
            580                 585                 590         


Arg Val Thr Asn Val Lys Val Thr Leu Arg Leu Asp Thr His Pro Ala 
        595                 600                 605             


Met Val Thr Val Leu Glu Met Gly Ala Ala Arg His Phe Leu Arg Met 
    610                 615                 620                 


Gln Gln Leu Ala Lys Thr Gln Glu Glu Arg Ala Gln Leu Leu Gln Pro 
625                 630                 635                 640 


Thr Leu Glu Ile Asn Pro Arg His Ala Leu Ile Lys Lys Leu Asn Gln 
                645                 650                 655     


Leu Arg Ala Ser Glu Pro Gly Leu Ala Gln Leu Leu Val Asp Gln Ile 
            660                 665                 670         


Tyr Glu Asn Ala Met Ile Ala Ala Gly Leu Val Asp Asp Pro Arg Ala 
        675                 680                 685             


Met Val Gly Arg Leu Asn Glu Leu Leu Val Lys Ala Leu Glu Arg His 
    690                 695                 700                 


<210> 187
<211> 2405
<212> DNA
<213> Homo sapiens

<400> 187
tccggcgtgg tgcgcaggcg cggtatcccc cctcccccgc cagctcgacc ccggtgtggt       60

gcgcaggcgc agtctgcgca gggactggcg ggactgcgcg gcggcaacag cagacatgtc      120

gggggtccgg ggcctgtcgc ggctgctgag cgctcggcgc ctggcgctgg ccaaggcgtg      180

gccaacagtg ttgcaaacag gaacccgagg ttttcacttc actgttgatg ggaacaagag      240

ggcatctgct aaagtttcag attccatttc tgctcagtat ccagtagtgg atcatgaatt      300

tgatgcagtg gtggtaggcg ctggaggggc aggcttgcga gctgcatttg gcctttctga      360

ggcagggttt aatacagcat gtgttaccaa gctgtttcct accaggtcac acactgttgc      420

agcacaggga ggaatcaatg ctgctctggg gaacatggag gaggacaact ggaggtggca      480

tttctacgac accgtgaagg gctccgactg gctgggggac caggatgcca tccactacat      540

gacggagcag gcccccgccg ccgtggtcga gctagaaaat tatggcatgc cgtttagcag      600

aactgaagat gggaagattt atcagcgtgc atttggtgga cagagcctca agtttggaaa      660

gggcgggcag gcccatcggt gctgctgtgt ggctgatcgg actggccact cgctattgca      720

caccttatat ggaaggtctc tgcgatatga taccagctat tttgtggagt attttgcctt      780

ggatctcctg atggagaatg gggagtgccg tggtgtcatc gcactgtgca tagaggacgg      840

gtccatccat cgcataagag caaagaacac tgttgttgcc acaggaggct acgggcgcac      900

ctacttcagc tgcacgtctg cccacaccag cactggcgac ggcacggcca tgatcaccag      960

ggcaggcctt ccttgccagg acctagagtt tgttcagttc caccctacag gcatatatgg     1020

tgctggttgt ctcattacgg aaggatgtcg tggagaggga ggcattctca ttaacagtca     1080

aggcgaaagg tttatggagc gatacgcccc tgtcgcgaag gacctggcgt ctagagatgt     1140

ggtgtctcgg tccatgactc tggagatccg agaaggaaga ggctgtggcc ctgagaaaga     1200

tcacgtctac ctgcagctgc accacctacc tccagagcag ctggccacgc gcctgcctgg     1260

catttcagag acagccatga tcttcgctgg cgtggacgtc acgaaggagc cgatccctgt     1320

cctccccacc gtgcattata acatgggcgg cattcccacc aactacaagg ggcaggtcct     1380

gaggcacgtg aatggccagg atcagattgt gcccggcctg tacgcctgtg gggaggccgc     1440

ctgtgcctcg gtacatggtg ccaaccgcct cggggcaaac tcgctcttgg acctggttgt     1500

ctttggtcgg gcatgtgccc tgagcatcga agagtcatgc aggcctggag ataaagtccc     1560

tccaattaaa ccaaacgctg gggaagaatc tgtcatgaat cttgacaaat tgagatttgc     1620

tgatggaagc ataagaacat cggaactgcg actcagcatg cagaagtcaa tgcaaaatca     1680

tgctgccgtg ttccgtgtgg gaagcgtgtt gcaagaaggt tgtgggaaaa tcagcaagct     1740

ctatggagac ctaaagcacc tgaagacgtt cgaccgggga atggtctgga acacggacct     1800

ggtggagacc ctggagctgc agaacctgat gctgtgtgcg ctgcagacca tctacggagc     1860

agaggcacgg aaggagtcac ggggcgcgca tgccagggaa gactacaagg tgcggattga     1920

tgagtacgat tactccaagc ccatccaggg gcaacagaag aagccctttg aggagcactg     1980

gaggaagcac accctgtcct atgtggacgt tggcactggg aaggtcactc tggaatatag     2040

acccgtgatc gacaaaactt tgaacgaggc tgactgtgcc accgtcccgc cagccattcg     2100

ctcctactga tgagacaaga tgtggtgatg acagaatcag cttttgtaat tatgtataat     2160

agctcatgca tgtgtccatg tcataactgt cttcatacgc ttctgcactc tggggaagaa     2220

ggagtacatt gaagggagat tggcacctag tggctgggag cttgccagga acccagtggc     2280

cagggagcgt ggcacttacc tttgtccctt gcttcattct tgtgagatga taaaactggg     2340

cacagctctt aaataaaata taaatgaaca aactttcttt tatttccaaa aaaaaaaaaa     2400

aaaaa                                                                 2405


<210> 188
<211> 664
<212> PRT
<213> Homo sapiens

<400> 188
Met Ser Gly Val Arg Gly Leu Ser Arg Leu Leu Ser Ala Arg Arg Leu 
1               5                   10                  15      


Ala Leu Ala Lys Ala Trp Pro Thr Val Leu Gln Thr Gly Thr Arg Gly 
            20                  25                  30          


Phe His Phe Thr Val Asp Gly Asn Lys Arg Ala Ser Ala Lys Val Ser 
        35                  40                  45              


Asp Ser Ile Ser Ala Gln Tyr Pro Val Val Asp His Glu Phe Asp Ala 
    50                  55                  60                  


Val Val Val Gly Ala Gly Gly Ala Gly Leu Arg Ala Ala Phe Gly Leu 
65                  70                  75                  80  


Ser Glu Ala Gly Phe Asn Thr Ala Cys Val Thr Lys Leu Phe Pro Thr 
                85                  90                  95      


Arg Ser His Thr Val Ala Ala Gln Gly Gly Ile Asn Ala Ala Leu Gly 
            100                 105                 110         


Asn Met Glu Glu Asp Asn Trp Arg Trp His Phe Tyr Asp Thr Val Lys 
        115                 120                 125             


Gly Ser Asp Trp Leu Gly Asp Gln Asp Ala Ile His Tyr Met Thr Glu 
    130                 135                 140                 


Gln Ala Pro Ala Ala Val Val Glu Leu Glu Asn Tyr Gly Met Pro Phe 
145                 150                 155                 160 


Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln 
                165                 170                 175     


Ser Leu Lys Phe Gly Lys Gly Gly Gln Ala His Arg Cys Cys Cys Val 
            180                 185                 190         


Ala Asp Arg Thr Gly His Ser Leu Leu His Thr Leu Tyr Gly Arg Ser 
        195                 200                 205             


Leu Arg Tyr Asp Thr Ser Tyr Phe Val Glu Tyr Phe Ala Leu Asp Leu 
    210                 215                 220                 


Leu Met Glu Asn Gly Glu Cys Arg Gly Val Ile Ala Leu Cys Ile Glu 
225                 230                 235                 240 


Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Val Val Ala Thr 
                245                 250                 255     


Gly Gly Tyr Gly Arg Thr Tyr Phe Ser Cys Thr Ser Ala His Thr Ser 
            260                 265                 270         


Thr Gly Asp Gly Thr Ala Met Ile Thr Arg Ala Gly Leu Pro Cys Gln 
        275                 280                 285             


Asp Leu Glu Phe Val Gln Phe His Pro Thr Gly Ile Tyr Gly Ala Gly 
    290                 295                 300                 


Cys Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Ile Asn 
305                 310                 315                 320 


Ser Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Val Ala Lys Asp 
                325                 330                 335     


Leu Ala Ser Arg Asp Val Val Ser Arg Ser Met Thr Leu Glu Ile Arg 
            340                 345                 350         


Glu Gly Arg Gly Cys Gly Pro Glu Lys Asp His Val Tyr Leu Gln Leu 
        355                 360                 365             


His His Leu Pro Pro Glu Gln Leu Ala Thr Arg Leu Pro Gly Ile Ser 
    370                 375                 380                 


Glu Thr Ala Met Ile Phe Ala Gly Val Asp Val Thr Lys Glu Pro Ile 
385                 390                 395                 400 


Pro Val Leu Pro Thr Val His Tyr Asn Met Gly Gly Ile Pro Thr Asn 
                405                 410                 415     


Tyr Lys Gly Gln Val Leu Arg His Val Asn Gly Gln Asp Gln Ile Val 
            420                 425                 430         


Pro Gly Leu Tyr Ala Cys Gly Glu Ala Ala Cys Ala Ser Val His Gly 
        435                 440                 445             


Ala Asn Arg Leu Gly Ala Asn Ser Leu Leu Asp Leu Val Val Phe Gly 
    450                 455                 460                 


Arg Ala Cys Ala Leu Ser Ile Glu Glu Ser Cys Arg Pro Gly Asp Lys 
465                 470                 475                 480 


Val Pro Pro Ile Lys Pro Asn Ala Gly Glu Glu Ser Val Met Asn Leu 
                485                 490                 495     


Asp Lys Leu Arg Phe Ala Asp Gly Ser Ile Arg Thr Ser Glu Leu Arg 
            500                 505                 510         


Leu Ser Met Gln Lys Ser Met Gln Asn His Ala Ala Val Phe Arg Val 
        515                 520                 525             


Gly Ser Val Leu Gln Glu Gly Cys Gly Lys Ile Ser Lys Leu Tyr Gly 
    530                 535                 540                 


Asp Leu Lys His Leu Lys Thr Phe Asp Arg Gly Met Val Trp Asn Thr 
545                 550                 555                 560 


Asp Leu Val Glu Thr Leu Glu Leu Gln Asn Leu Met Leu Cys Ala Leu 
                565                 570                 575     


Gln Thr Ile Tyr Gly Ala Glu Ala Arg Lys Glu Ser Arg Gly Ala His 
            580                 585                 590         


Ala Arg Glu Asp Tyr Lys Val Arg Ile Asp Glu Tyr Asp Tyr Ser Lys 
        595                 600                 605             


Pro Ile Gln Gly Gln Gln Lys Lys Pro Phe Glu Glu His Trp Arg Lys 
    610                 615                 620                 


His Thr Leu Ser Tyr Val Asp Val Gly Thr Gly Lys Val Thr Leu Glu 
625                 630                 635                 640 


Tyr Arg Pro Val Ile Asp Lys Thr Leu Asn Glu Ala Asp Cys Ala Thr 
                645                 650                 655     


Val Pro Pro Ala Ile Arg Ser Tyr 
            660                 


<210> 189
<211> 2630
<212> DNA
<213> Homo sapiens

<400> 189
ataaggccct ctcctccacc ctgccaggct cactctgccc cacagccaca gcccctgact       60

gccgcagccc ccacagagcc cgccgcgcac cccacgtccc ccacgccagc gcccagccat      120

ggaggccatc aagaagaaaa tgcagatgct gaagttggac aaggagaatg ccatcgaccg      180

cgcggagcag gcggaggcgg ataagaaagc cgctgaggac aagtgcaagc aggtggagga      240

ggagctgacg cacctccaga agaaactaaa agggacagag gacgagctgg ataaatattc      300

cgaggacctg aaggacgcgc aggagaagct ggagctcacg gagaagaagg cctccgacgc      360

tgaaggtgat gtggccgccc tcaaccgacg catccagctc gttgaggagg agttggacag      420

ggctcaggaa cgactggcca cggccctgca gaagctggag gaggcagaaa aagctgcaga      480

tgagagtgag agaggaatga aggtgataga aaaccgggcc atgaaggatg aggagaagat      540

ggagattcag gagatgcagc tcaaagaggc caagcacatt gcggaagagg ctgaccgcaa      600

atacgaggag gtagctcgta agctggtcat cctggagggt gagctggaga gggcagagga      660

gcgtgcggag gtgtctgaac taaaatgtgg tgacctggaa gaagaactca agaatgttac      720

taacaatctg aaatctctgg aggctgcatc tgaaaagtat tctgaaaagg aggacaaata      780

tgaagaagaa attaaacttc tgtctgacaa actgaaagag gctgagaccc gtgctgaatt      840

tgcagagaga acggttgcaa aactggaaaa gacaattgat gacctggaag agaaacttgc      900

ccaggccaaa gaagagaacg tgggcttaca tcagacactg gatcagacac taaacgaact      960

taactgtata taagcaaaac agaagagtct tgttccaaca gaaactctgg agctccgtgg     1020

gtctttctct tctcttgtaa gaagttcctt ttgttattgc catcttcgct ttgctggaaa     1080

tgtcaagcaa attatgaata catgaccaaa tattttgtat cggagaagct ttgagcacca     1140

gttaaatctc attccttccc tttttttttc aaatggcacc agctttttca gctctcttat     1200

tttttcctta agtagcattt attcctaagg taggcagggt atttcctagt aagcatactt     1260

tcttaagacg gaggccattt ggttcctggg agaataggca gccccacact ttgaagaata     1320

cagaccccag tatctagtcg tggatataat taaaacgctg aagaccataa ccttttgggt     1380

caactgttgg tcaaactata ggagagacca gggaccatca catgggtagg gattttccat     1440

ccagagccaa taaaaggact ggtgggggcc gggggtggct attgtgggaa gtcataaccc     1500

acagatagat caacctaaga atcctggccc ttctccactc tccaccatgc aggacaaaca     1560

tcttctcaag cagtcaacgt agaatgcttg ggaaatagtc ataattaccc acatatagta     1620

attaatagat ggtaattaat tgatccttga tgtgatgttc ttttgcatat ttccttcatt     1680

ctaaagttgt tccctggccg ggagcgttgg ctttcgcctg taatcccaac actttgggag     1740

gccaggacag atcacttgag gtcaggagtt cgagaccagc ccagccaaca tggcgaaacc     1800

atgtctctac taaaaataca aaaattatgg tgacgcctgc ctgtagtccc agctactcgg     1860

gaggctgagg caggaggatc gcttgaaccc aggaagtgga gactgcagtg agccgatatc     1920

gcaccacagc gctccagcct ggtcgacaga gtgagactcc atctcaagaa aaaataaaaa     1980

taaagttgtt ctctgaagag caaatgtctc attccagtaa tgacccactc agcaggaata     2040

tggtggagtt cagtccaatt caggtcagcc atatccaaaa gaccacaagt cattactaag     2100

ttgagcaaaa gagtttttat ctattagcag aaagggcctc tctggcagca gagattaaaa     2160

actggcccaa cttcatttcc atacttcagg gaacagcaaa ttgaggattt acttatctag     2220

gacttgaatt ccttctttgg gaccaagtta ataaaagacc aagaaactcc tgattaaact     2280

ggataatgaa ggattctgta gacagggctg cacgtatcgg ctttgtttga cttctctttt     2340

ctcagttaac atctcagagc tagaacattc cacattcccc agcagcgtgt gggggctgac     2400

taaagtttac aattccaact aaaaatcacc ctgcttctgg cttatctgaa tcccttaccc     2460

accccacccc accaccctac tcctatttat tcagcaccac actacccagg aaatacacta     2520

gcaaattgtg caatggaata aaatccacac tttagattct tgcaactgta tcatatgtaa     2580

tagtatcact ttttctacat tttggtcaaa taaattttta cataaactac                2630


<210> 190
<211> 284
<212> PRT
<213> Homo sapiens

<400> 190
Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Ile Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Lys Cys Lys Gln Val Glu Glu Glu Leu Thr His Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Asp Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Thr Glu Lys Lys Ala Ser Asp 
65                  70                  75                  80  


Ala Glu Gly Asp Val Ala Ala Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Asn Arg Ala Met Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Met Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Val Ser Glu Leu Lys Cys Gly Asp 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Ala Ser Glu Lys Tyr Ser Glu Lys Glu Asp Lys Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Leu Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Thr Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Leu Ala Gln Ala Lys Glu Glu Asn Val Gly Leu His Gln 
            260                 265                 270         


Thr Leu Asp Gln Thr Leu Asn Glu Leu Asn Cys Ile 
        275                 280                 


<210> 191
<211> 2645
<212> DNA
<213> Homo sapiens

<400> 191
tttccagcag ctgtggccag cggtgccgac gtcaggccct cccccagcgg tgctgacgtc       60

ggcggtccgg ccgggtgacc tcatcgcccc gacggcagcc ggcccggggg gcggggagag      120

gcgggggcgg cccccgcgca ggcaaaggct tggggggccg gggcgcggct gtgcagctct      180

cgccggagcc gagcccagcc gagcgtccgc cgctgcccgt gcgcctctgc gcctccgcgc      240

catggccggc ctcaactccc tggaggcggt gaaacgcaag atccaggccc tgcagcagca      300

ggcggacgag gcggaagacc gcgcgcaggg cctgcagcgg gagctggacg gcgagcgcga      360

gcggcgcgag aaagctgaag gtgatgtggc cgccctcaac cgacgcatcc agctcgttga      420

ggaggagttg gacagggctc aggaacgact ggccacggcc ctgcagaagc tggaggaggc      480

agaaaaagct gcagatgaga gtgagagagg aatgaaggtg atagaaaacc gggccatgaa      540

ggatgaggag aagatggaga ttcaggagat gcagctcaaa gaggccaagc acattgcgga      600

agaggctgac cgcaaatacg aggaggtagc tcgtaagctg gtcatcctgg agggtgagct      660

ggagagggca gaggagcgtg cggaggtgtc tgaactaaaa tgtggtgacc tggaagaaga      720

actcaagaat gttactaaca atctgaaatc tctggaggct gcatctgaaa agtattctga      780

aaaggaggac aaatatgaag aagaaattaa acttctgtct gacaaactga aagaggctga      840

gacccgtgct gaatttgcag agagaacggt tgcaaaactg gaaaagacaa ttgatgacct      900

ggaagagaaa cttgcccagg ccaaagaaga gaacgtgggc ttacatcaga cactggatca      960

gacactaaac gaacttaact gtatataagc aaaacagaag agtcttgttc caacagaaac     1020

tctggagctc cgtgggtctt tctcttctct tgtaagaagt tccttttgtt attgccatct     1080

tcgctttgct ggaaatgtca agcaaattat gaatacatga ccaaatattt tgtatcggag     1140

aagctttgag caccagttaa atctcattcc ttcccttttt ttttcaaatg gcaccagctt     1200

tttcagctct cttatttttt ccttaagtag catttattcc taaggtaggc agggtatttc     1260

ctagtaagca tactttctta agacggaggc catttggttc ctgggagaat aggcagcccc     1320

acactttgaa gaatacagac cccagtatct agtcgtggat ataattaaaa cgctgaagac     1380

cataaccttt tgggtcaact gttggtcaaa ctataggaga gaccagggac catcacatgg     1440

gtagggattt tccatccaga gccaataaaa ggactggtgg gggccggggg tggctattgt     1500

gggaagtcat aacccacaga tagatcaacc taagaatcct ggcccttctc cactctccac     1560

catgcaggac aaacatcttc tcaagcagtc aacgtagaat gcttgggaaa tagtcataat     1620

tacccacata tagtaattaa tagatggtaa ttaattgatc cttgatgtga tgttcttttg     1680

catatttcct tcattctaaa gttgttccct ggccgggagc gttggctttc gcctgtaatc     1740

ccaacacttt gggaggccag gacagatcac ttgaggtcag gagttcgaga ccagcccagc     1800

caacatggcg aaaccatgtc tctactaaaa atacaaaaat tatggtgacg cctgcctgta     1860

gtcccagcta ctcgggaggc tgaggcagga ggatcgcttg aacccaggaa gtggagactg     1920

cagtgagccg atatcgcacc acagcgctcc agcctggtcg acagagtgag actccatctc     1980

aagaaaaaat aaaaataaag ttgttctctg aagagcaaat gtctcattcc agtaatgacc     2040

cactcagcag gaatatggtg gagttcagtc caattcaggt cagccatatc caaaagacca     2100

caagtcatta ctaagttgag caaaagagtt tttatctatt agcagaaagg gcctctctgg     2160

cagcagagat taaaaactgg cccaacttca tttccatact tcagggaaca gcaaattgag     2220

gatttactta tctaggactt gaattccttc tttgggacca agttaataaa agaccaagaa     2280

actcctgatt aaactggata atgaaggatt ctgtagacag ggctgcacgt atcggctttg     2340

tttgacttct cttttctcag ttaacatctc agagctagaa cattccacat tccccagcag     2400

cgtgtggggg ctgactaaag tttacaattc caactaaaaa tcaccctgct tctggcttat     2460

ctgaatccct tacccacccc accccaccac cctactccta tttattcagc accacactac     2520

ccaggaaata cactagcaaa ttgtgcaatg gaataaaatc cacactttag attcttgcaa     2580

ctgtatcata tgtaatagta tcactttttc tacattttgg tcaaataaat ttttacataa     2640

actac                                                                 2645


<210> 192
<211> 248
<212> PRT
<213> Homo sapiens

<400> 192
Met Ala Gly Leu Asn Ser Leu Glu Ala Val Lys Arg Lys Ile Gln Ala 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Glu Ala Glu Asp Arg Ala Gln Gly Leu Gln 
            20                  25                  30          


Arg Glu Leu Asp Gly Glu Arg Glu Arg Arg Glu Lys Ala Glu Gly Asp 
        35                  40                  45              


Val Ala Ala Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Met Lys Asp Glu Glu Lys Met Glu Ile Gln Glu Met Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu Glu Arg Ala Glu 
    130                 135                 140                 


Glu Arg Ala Glu Val Ser Glu Leu Lys Cys Gly Asp Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Ala Ser Glu 
                165                 170                 175     


Lys Tyr Ser Glu Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Leu Leu 
            180                 185                 190         


Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Thr Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Lys Leu 
    210                 215                 220                 


Ala Gln Ala Lys Glu Glu Asn Val Gly Leu His Gln Thr Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Asn Glu Leu Asn Cys Ile 
                245             


<210> 193
<211> 1369
<212> DNA
<213> Homo sapiens

<400> 193
attaggtgac tggctgaggc ggcgccagtt ggccgggcac ggggctgctg taaggccgag       60

gttgcggcgg aagcggagac catgttccga gcggcggctc cggggcagct ccggcgggcg      120

gcctcattgc tacgatttca gagtaccctg gtaatagctg agcatgcaaa tgattcccta      180

gcacccatta ctttaaatac cattactgca gccacacgcc ttggaggtga agtgtcctgc      240

ttagtagctg gaaccaaatg tgacaaggtg gcacaagatc tctgtaaagt agcaggcata      300

gcaaaagttc tggtggctca gcatgatgtg tacaaaggcc tacttccaga ggaactgaca      360

ccattgattt tggcaactca gaagcagttc aattacacac acatctgtgc tggagcatct      420

gccttcggaa agaacctttt gcccagagta gcagccaaac ttgaggttgc cccgatttct      480

gacatcattg caatcaagtc acctgacaca tttgtgagaa ctatttatgc aggaaatgct      540

ctatgtacag tgaagtgtga tgagaaagtg aaagtgtttt ctgtccgtgg aacatccttt      600

gatgctgcag caacaagtgg cggtagtgcc agttcagaaa aggcatcaag tacttcacca      660

gtggaaatat cagagtggct tgaccagaaa ttaacaaaaa gtgatcgacc agagctaaca      720

ggtgccaaag tggtggtatc tggtggtcga ggcttgaaga gtggagagaa ctttaagttg      780

ttatatgact tggcagatca actacatgct gcagttggtg cttcccgtgc tgctgttgat      840

gctggctttg ttcccaatga catgcaagtt ggacagacgg gaaaaatagt agcaccagaa      900

ctttatattg ctgttggaat atctggagcc atccaacatt tagctgggat gaaagacagc      960

aagacaattg tggcaattaa taaagaccca gaagctccaa ttttccaagt ggcagattat     1020

ggaatagttg cagatttatt taaggtagtt cctgaaatga ctgagatatt gaagaaaaaa     1080

tgaatcagga tcatgcctta aaaagaaaac ttttgttaaa gtattccact gaaatcacag     1140

atatttgtgg gtattataac aatcattgga aagcatggag agctacattt cataatttga     1200

gggaaaattt ctaacagatg ccagaatgct tgtttatggg attgctgtgt ttccttttaa     1260

ttatttgtgg ttccaaacaa ttattgtttg aactttttaa attctgtact aaaatctata     1320

ataaagcttt tccacagctt taaaactatc agaaaaaaaa aaaaaaaaa                 1369


<210> 194
<211> 333
<212> PRT
<213> Homo sapiens

<400> 194
Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
1               5                   10                  15      


Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
            20                  25                  30          


Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
        35                  40                  45              


Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
    50                  55                  60                  


Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
65                  70                  75                  80  


His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                85                  90                  95      


Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
            100                 105                 110         


Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
        115                 120                 125             


Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
    130                 135                 140                 


Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
145                 150                 155                 160 


Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                165                 170                 175     


Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
            180                 185                 190         


Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
        195                 200                 205             


Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
    210                 215                 220                 


Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
225                 230                 235                 240 


Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                245                 250                 255     


Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
            260                 265                 270         


Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
        275                 280                 285             


Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
    290                 295                 300                 


Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
305                 310                 315                 320 


Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                325                 330             


<210> 195
<211> 1222
<212> DNA
<213> Homo sapiens

<400> 195
attaggtgac tggctgaggc ggcgccagtt ggccgggcac ggggctgctg taaggccgag       60

gttgcggcgg aagcggagac catgttccga gcggcggctc cggggcagct ccggcgggcg      120

gtggcacaag atctctgtaa agtagcaggc atagcaaaag ttctggtggc tcagcatgat      180

gtgtacaaag gcctacttcc agaggaactg acaccattga ttttggcaac tcagaagcag      240

ttcaattaca cacacatctg tgctggagca tctgccttcg gaaagaacct tttgcccaga      300

gtagcagcca aacttgaggt tgccccgatt tctgacatca ttgcaatcaa gtcacctgac      360

acatttgtga gaactattta tgcaggaaat gctctatgta cagtgaagtg tgatgagaaa      420

gtgaaagtgt tttctgtccg tggaacatcc tttgatgctg cagcaacaag tggcggtagt      480

gccagttcag aaaaggcatc aagtacttca ccagtggaaa tatcagagtg gcttgaccag      540

aaattaacaa aaagtgatcg accagagcta acaggtgcca aagtggtggt atctggtggt      600

cgaggcttga agagtggaga gaactttaag ttgttatatg acttggcaga tcaactacat      660

gctgcagttg gtgcttcccg tgctgctgtt gatgctggct ttgttcccaa tgacatgcaa      720

gttggacaga cgggaaaaat agtagcacca gaactttata ttgctgttgg aatatctgga      780

gccatccaac atttagctgg gatgaaagac agcaagacaa ttgtggcaat taataaagac      840

ccagaagctc caattttcca agtggcagat tatggaatag ttgcagattt atttaaggta      900

gttcctgaaa tgactgagat attgaagaaa aaatgaatca ggatcatgcc ttaaaaagaa      960

aacttttgtt aaagtattcc actgaaatca cagatatttg tgggtattat aacaatcatt     1020

ggaaagcatg gagagctaca tttcataatt tgagggaaaa tttctaacag atgccagaat     1080

gcttgtttat gggattgctg tgtttccttt taattatttg tggttccaaa caattattgt     1140

ttgaactttt taaattctgt actaaaatct ataataaagc ttttccacag ctttaaaact     1200

atcagaaaaa aaaaaaaaaa aa                                              1222


<210> 196
<211> 284
<212> PRT
<213> Homo sapiens

<400> 196
Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Val Ala Gln 
1               5                   10                  15      


Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln His 
            20                  25                  30          


Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile Leu 
        35                  40                  45              


Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala Ser 
    50                  55                  60                  


Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu Val 
65                  70                  75                  80  


Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe Val 
                85                  90                  95      


Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp Glu 
            100                 105                 110         


Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala Ala 
        115                 120                 125             


Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser Pro 
    130                 135                 140                 


Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp Arg 
145                 150                 155                 160 


Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly Leu 
                165                 170                 175     


Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln Leu 
            180                 185                 190         


His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe Val 
        195                 200                 205             


Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro Glu 
    210                 215                 220                 


Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala Gly 
225                 230                 235                 240 


Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu Ala 
                245                 250                 255     


Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe Lys 
            260                 265                 270         


Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
        275                 280                 


<210> 197
<211> 903
<212> DNA
<213> Homo sapiens

<400> 197
agataaggcc gctcgctgac gccgtgtttc ctctttcggc cgcgctggtg aacaggaccc       60

gtcgccatgg gccgtgtgat ccgtggacag aggaagggcg ccgggtctgt gttccgcgcg      120

cacgtgaagc accgtaaagg cgctgcgcgc ctgcgcgccg tggatttcgc tgagcggcac      180

ggctacatca agggcatcgt caaggacatc atccacgacc cgggccgcgg cgcgcccctc      240

gccaaggtgg tcttccggga tccgtatcgg tttaagaagc ggacggagct gttcattgcc      300

gccgagggca ttcacacggg ccagtttgtg tattgcggca agaaggccca gctcaacatt      360

ggcaatgtgc tccctgtggg caccatgcct gagggtacaa tcgtgtgctg cctggaggag      420

aagcctggag accgtggcaa gctggcccgg gcatcaggga actatgccac cgttatctcc      480

cacaaccctg agaccaagaa gacccgtgtg aagctgccct ccggctccaa gaaggttatc      540

tcctcagcca acagagctgt ggttggtgtg gtggctggag gtggccgaat tgacaaaccc      600

atcttgaagg ctggccgggc gtaccacaaa tataaggcaa agaggaactg ctggccacga      660

gtacggggtg tggccatgaa tcctgtggag catccttttg gaggtggcaa ccaccagcac      720

atcggcaagc cctccaccat ccgcagagat gcccctgctg gccgcaaagt gggtctcatt      780

gctgcccgcc ggactggacg tctccgggga accaagactg tgcaggagaa agagaactag      840

tgctgagggc ctcaataaag tttgtgttta tgccaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaa                                                                    903


<210> 198
<211> 257
<212> PRT
<213> Homo sapiens

<400> 198
Met Gly Arg Val Ile Arg Gly Gln Arg Lys Gly Ala Gly Ser Val Phe 
1               5                   10                  15      


Arg Ala His Val Lys His Arg Lys Gly Ala Ala Arg Leu Arg Ala Val 
            20                  25                  30          


Asp Phe Ala Glu Arg His Gly Tyr Ile Lys Gly Ile Val Lys Asp Ile 
        35                  40                  45              


Ile His Asp Pro Gly Arg Gly Ala Pro Leu Ala Lys Val Val Phe Arg 
    50                  55                  60                  


Asp Pro Tyr Arg Phe Lys Lys Arg Thr Glu Leu Phe Ile Ala Ala Glu 
65                  70                  75                  80  


Gly Ile His Thr Gly Gln Phe Val Tyr Cys Gly Lys Lys Ala Gln Leu 
                85                  90                  95      


Asn Ile Gly Asn Val Leu Pro Val Gly Thr Met Pro Glu Gly Thr Ile 
            100                 105                 110         


Val Cys Cys Leu Glu Glu Lys Pro Gly Asp Arg Gly Lys Leu Ala Arg 
        115                 120                 125             


Ala Ser Gly Asn Tyr Ala Thr Val Ile Ser His Asn Pro Glu Thr Lys 
    130                 135                 140                 


Lys Thr Arg Val Lys Leu Pro Ser Gly Ser Lys Lys Val Ile Ser Ser 
145                 150                 155                 160 


Ala Asn Arg Ala Val Val Gly Val Val Ala Gly Gly Gly Arg Ile Asp 
                165                 170                 175     


Lys Pro Ile Leu Lys Ala Gly Arg Ala Tyr His Lys Tyr Lys Ala Lys 
            180                 185                 190         


Arg Asn Cys Trp Pro Arg Val Arg Gly Val Ala Met Asn Pro Val Glu 
        195                 200                 205             


His Pro Phe Gly Gly Gly Asn His Gln His Ile Gly Lys Pro Ser Thr 
    210                 215                 220                 


Ile Arg Arg Asp Ala Pro Ala Gly Arg Lys Val Gly Leu Ile Ala Ala 
225                 230                 235                 240 


Arg Arg Thr Gly Arg Leu Arg Gly Thr Lys Thr Val Gln Glu Lys Glu 
                245                 250                 255     


Asn 
    


<210> 199
<211> 967
<212> DNA
<213> Homo sapiens

<400> 199
gcggcatggg cagtatccgc cgccatcctc ttccgtgagg cgcgctgaga cccggaccgg       60

ccctcctgag aggatgccgg tgcgggcgcc cgcggagagg gacccgtcgc catgggccgt      120

gtgatccgtg gacagaggaa gggcgccggg tctgtgttcc gcgcgcacgt gaagcaccgt      180

aaaggcgctg cgcgcctgcg cgccgtggat ttcgctgagc ggcacggcta catcaagggc      240

atcgtcaagg acatcatcca cgacccgggc cgcggcgcgc ccctcgccaa ggtggtcttc      300

cgggatccgt atcggtttaa gaagcggacg gagctgttca ttgccgccga gggcattcac      360

acgggccagt ttgtgtattg cggcaagaag gcccagctca acattggcaa tgtgctccct      420

gtgggcacca tgcctgaggg tacaatcgtg tgctgcctgg aggagaagcc tggagaccgt      480

ggcaagctgg cccgggcatc agggaactat gccaccgtta tctcccacaa ccctgagacc      540

aagaagaccc gtgtgaagct gccctccggc tccaagaagg ttatctcctc agccaacaga      600

gctgtggttg gtgtggtggc tggaggtggc cgaattgaca aacccatctt gaaggctggc      660

cgggcgtacc acaaatataa ggcaaagagg aactgctggc cacgagtacg gggtgtggcc      720

atgaatcctg tggagcatcc ttttggaggt ggcaaccacc agcacatcgg caagccctcc      780

accatccgca gagatgcccc tgctggccgc aaagtgggtc tcattgctgc ccgccggact      840

ggacgtctcc ggggaaccaa gactgtgcag gagaaagaga actagtgctg agggcctcaa      900

taaagtttgt gtttatgcca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaa                                                                967


<210> 200
<211> 257
<212> PRT
<213> Homo sapiens

<400> 200
Met Gly Arg Val Ile Arg Gly Gln Arg Lys Gly Ala Gly Ser Val Phe 
1               5                   10                  15      


Arg Ala His Val Lys His Arg Lys Gly Ala Ala Arg Leu Arg Ala Val 
            20                  25                  30          


Asp Phe Ala Glu Arg His Gly Tyr Ile Lys Gly Ile Val Lys Asp Ile 
        35                  40                  45              


Ile His Asp Pro Gly Arg Gly Ala Pro Leu Ala Lys Val Val Phe Arg 
    50                  55                  60                  


Asp Pro Tyr Arg Phe Lys Lys Arg Thr Glu Leu Phe Ile Ala Ala Glu 
65                  70                  75                  80  


Gly Ile His Thr Gly Gln Phe Val Tyr Cys Gly Lys Lys Ala Gln Leu 
                85                  90                  95      


Asn Ile Gly Asn Val Leu Pro Val Gly Thr Met Pro Glu Gly Thr Ile 
            100                 105                 110         


Val Cys Cys Leu Glu Glu Lys Pro Gly Asp Arg Gly Lys Leu Ala Arg 
        115                 120                 125             


Ala Ser Gly Asn Tyr Ala Thr Val Ile Ser His Asn Pro Glu Thr Lys 
    130                 135                 140                 


Lys Thr Arg Val Lys Leu Pro Ser Gly Ser Lys Lys Val Ile Ser Ser 
145                 150                 155                 160 


Ala Asn Arg Ala Val Val Gly Val Val Ala Gly Gly Gly Arg Ile Asp 
                165                 170                 175     


Lys Pro Ile Leu Lys Ala Gly Arg Ala Tyr His Lys Tyr Lys Ala Lys 
            180                 185                 190         


Arg Asn Cys Trp Pro Arg Val Arg Gly Val Ala Met Asn Pro Val Glu 
        195                 200                 205             


His Pro Phe Gly Gly Gly Asn His Gln His Ile Gly Lys Pro Ser Thr 
    210                 215                 220                 


Ile Arg Arg Asp Ala Pro Ala Gly Arg Lys Val Gly Leu Ile Ala Ala 
225                 230                 235                 240 


Arg Arg Thr Gly Arg Leu Arg Gly Thr Lys Thr Val Gln Glu Lys Glu 
                245                 250                 255     


Asn 
    


<210> 201
<211> 4032
<212> DNA
<213> Homo sapiens

<400> 201
gaagacgtgg cttggggccg ccatcttggc aagaggcgaa gcggcagcgg ttcctgtcaa       60

gggggcagca ggtccagagc tgctggtgct cccgttcccc agaccctacc cctatcccca      120

gtggagccgg agtgcgggcg cgccccacca ccgccctcac catggtgctg ttggcagcag      180

cggtctgcac aaaagcagga aaggctattg tttctcgaca gtttgtggaa atgacccgaa      240

ctcggattga gggcttatta gcagcttttc caaagctcat gaacactgga aaacaacata      300

cgtttgttga aacagagagt gtaagatatg tctaccagcc tatggagaaa ctgtatatgg      360

tactgatcac taccaaaaac agcaacattt tagaagattt ggagacccta aggctcttct      420

caagagtgat ccctgaatat tgccgagcct tagaagagaa tgaaatatct gagcactgtt      480

ttgatttgat ttttgctttt gatgaaattg tcgcactggg ataccgggag aatgttaact      540

tggcacagat cagaaccttc acagaaatgg attctcatga ggagaaggtg ttcagagccg      600

tcagagagac tcaagaacgt gaagctaagg ctgagatgcg tcgtaaagca aaggaattac      660

aacaggcccg aagagatgca gagagacagg gcaaaaaagc accaggattt ggcggatttg      720

gcagctctgc agtatctgga ggcagcacag ctgccatgat cacagagacc atcattgaaa      780

ctgataaacc aaaagtggca cctgcaccag ccaggccttc aggccccagc aaggctttaa      840

aacttggagc caaaggaaag gaagtagata actttgtgga caaattaaaa tctgaaggtg      900

aaaccatcat gtcctctagt atgggcaagc gtacttctga agcaaccaaa atgcatgctc      960

cacccattaa tatggaaagt gtacatatga agattgaaga aaagataaca ttaacctgtg     1020

gacgagacgg aggattacag aatatggagt tgcatggcat gatcatgctt aggatctcag     1080

atgacaagta tggccgaatt cgtcttcatg tggaaaatga agataagaaa ggggtgcagc     1140

tacagaccca tccaaatgtg gataaaaaac ttttcactgc agagtctcta attggcctga     1200

agaatccaga gaagtcattt ccagtcaaca gtgacgtagg ggtgctaaag tggagactac     1260

aaaccacaga ggaatctttt attccactga caattaattg ctggccctcg gagagtggaa     1320

atggctgtga tgtcaacata gaatatgagc tacaagaaga taatttagaa ctgaatgatg     1380

tggttatcac catcccactc ccgtctggtg tcggcgcgcc tgttatcggt gagatcgatg     1440

gggagtatcg acatgacagt cgacgaaata ccctggagtg gtgcctgcct gtgattgatg     1500

ccaaaaataa gagtggcagc ctggagttta gcattgctgg gcagcccaat gacttcttcc     1560

ctgttcaagt ttcctttgtc tccaagaaaa attactgtaa catacaggtt accaaagtga     1620

cccaggtaga tggaaacagc cccgtcaggt tttccacaga gaccactttc ctagtggata     1680

agtatgaaat tctgtaatac caagaagagg gagctgaaaa ggaaaatttt cagattaata     1740

aagaagacgc caatgatggc tgaagagttt ttcccagatt tacaagccac tggagacccc     1800

ttttttctga tacaatgcac gattctctgc gcgcaaggac cctcgactca cccccatgtt     1860

tcagtgtcac agagacattc tttgataagg aaatggcaca aacataaagg gaaaggctgc     1920

taattttctt tggcagattg tattggccag caggaaagca agctctccag agaatgcccc     1980

cagttaaata cctcctctac ctttacctaa gttgctcctt tatttttatt ttattattat     2040

tattattatt attattattt tttgagatgg agtctcactt tgtaacccag gctggaatgc     2100

aatggcatga tctcagctca ctgcaacctc cgcctcctgg gttcaagcaa gtctcctgcc     2160

tcagcctccg agtagctggg actacaggtg cacgccacca cgcctggcta attttttgta     2220

ttttagtaga gacggggttt caccgtgttg cccaggctgg tcgcgaactc ctgagctcag     2280

gcaatccgcc cacctcagcc tcccaaagtg ttgggattac aggcatgagc caccatgccc     2340

agctgctcct ttattttaat ccctaaatat aatccctaaa tatagttata tttcatactt     2400

agtttgtttt taaaaagttt tctctgtaga aaattttaat cattcatacc ctttaccttt     2460

aggtttttct ttctatacat tcagtcaggc actgggatca tctgtttaca ggcattatat     2520

ttatttggca ctcctggaac aagtatatct aacccattct tgatttttgg actattcagg     2580

tgaactattt gaggggtatg gggtctagaa gttaaaagat acgcatgtct tctgttcttt     2640

tcccgtatca attcattcct tcatctcttt gccaagttgt tttcctttca gggcctgtcc     2700

ttccagttta gaacagtacc atgaatccca cttgtgtcaa tattaaagat agctgagaag     2760

cacctttcaa atggcacagt ccctcttcaa gatgtctaaa agaatggtta tgtctgtcca     2820

gttagggatt tcacatccac atgtaatcat gtctgctgct gttgctaccc aaattttcat     2880

ttctccacat tttgggtact taagctaaaa cgtaatggcc acagtctgta atccattcac     2940

attcctcagt ttcaccacct ccctcttcca gactgcactc tctgtcatca gtcccctcct     3000

ttctaacaga aatggggtta tgattttgaa ggctgtgggt tcagggagtc tttgccaatc     3060

ctgttggccc taaactatca aggaggctcc atttcaccat ttgatttttt gcatttcagg     3120

aggcaactga ttgtttcgat atgtacatat tactcacgta taccccattt ccttccagtc     3180

agcccaacat tttccaccag tctgtcccca tctctgaaat ccttccttct ctttccccct     3240

aagtcttttg agtgtcatca tgtactggtg gtttctcggt tccatctcat ccatttcctt     3300

ttcaatggag actacagcgt cagccagctc agccttggct tttaactcaa tattccagtc     3360

cataggggtg gttaaaagtt gctgcaaggc tgcaggcact ggcagtggga agaggcagac     3420

gactagatga cttctgcact tttagctggt tgaaaagtac cactcccact ctgaacatct     3480

ggccgtccct gcaaagagtg tactgtgctt gaagcagagc actcacacat aaatggctgt     3540

gtgtggaatt gcttgccaaa gaagtttcta gcctttccct ttcccctaac tgcatcaggg     3600

aagaattctt atctctagct tggtttccac atgaggtttt tctgagaagg gcttgggaca     3660

agaagtctgt catgttagtt aagcaggcaa gaaatcctac taatccagtt ttgtttgaaa     3720

gttgtttgtc cgtatgattt tttaaaagtc aagtttaatt tcaaaaaacc ttttttttct     3780

gagattactt ttggggtaat atttaaaatg agagacattt tgtaaccctg taaaatacat     3840

agggaatata acattccagt gtatacaaag aaggcaaatt ctttaatcaa ataaagcgca     3900

ttataaaatg agatgtttat tggattattg actcactttg gtgtctgctt gttgattcag     3960

gatgctgtaa tgggacctaa cattaaaaat taatgacatg ttttttttaa gagaaaaaaa     4020

aaaaaaaaaa aa                                                         4032


<210> 202
<211> 511
<212> PRT
<213> Homo sapiens

<400> 202
Met Val Leu Leu Ala Ala Ala Val Cys Thr Lys Ala Gly Lys Ala Ile 
1               5                   10                  15      


Val Ser Arg Gln Phe Val Glu Met Thr Arg Thr Arg Ile Glu Gly Leu 
            20                  25                  30          


Leu Ala Ala Phe Pro Lys Leu Met Asn Thr Gly Lys Gln His Thr Phe 
        35                  40                  45              


Val Glu Thr Glu Ser Val Arg Tyr Val Tyr Gln Pro Met Glu Lys Leu 
    50                  55                  60                  


Tyr Met Val Leu Ile Thr Thr Lys Asn Ser Asn Ile Leu Glu Asp Leu 
65                  70                  75                  80  


Glu Thr Leu Arg Leu Phe Ser Arg Val Ile Pro Glu Tyr Cys Arg Ala 
                85                  90                  95      


Leu Glu Glu Asn Glu Ile Ser Glu His Cys Phe Asp Leu Ile Phe Ala 
            100                 105                 110         


Phe Asp Glu Ile Val Ala Leu Gly Tyr Arg Glu Asn Val Asn Leu Ala 
        115                 120                 125             


Gln Ile Arg Thr Phe Thr Glu Met Asp Ser His Glu Glu Lys Val Phe 
    130                 135                 140                 


Arg Ala Val Arg Glu Thr Gln Glu Arg Glu Ala Lys Ala Glu Met Arg 
145                 150                 155                 160 


Arg Lys Ala Lys Glu Leu Gln Gln Ala Arg Arg Asp Ala Glu Arg Gln 
                165                 170                 175     


Gly Lys Lys Ala Pro Gly Phe Gly Gly Phe Gly Ser Ser Ala Val Ser 
            180                 185                 190         


Gly Gly Ser Thr Ala Ala Met Ile Thr Glu Thr Ile Ile Glu Thr Asp 
        195                 200                 205             


Lys Pro Lys Val Ala Pro Ala Pro Ala Arg Pro Ser Gly Pro Ser Lys 
    210                 215                 220                 


Ala Leu Lys Leu Gly Ala Lys Gly Lys Glu Val Asp Asn Phe Val Asp 
225                 230                 235                 240 


Lys Leu Lys Ser Glu Gly Glu Thr Ile Met Ser Ser Ser Met Gly Lys 
                245                 250                 255     


Arg Thr Ser Glu Ala Thr Lys Met His Ala Pro Pro Ile Asn Met Glu 
            260                 265                 270         


Ser Val His Met Lys Ile Glu Glu Lys Ile Thr Leu Thr Cys Gly Arg 
        275                 280                 285             


Asp Gly Gly Leu Gln Asn Met Glu Leu His Gly Met Ile Met Leu Arg 
    290                 295                 300                 


Ile Ser Asp Asp Lys Tyr Gly Arg Ile Arg Leu His Val Glu Asn Glu 
305                 310                 315                 320 


Asp Lys Lys Gly Val Gln Leu Gln Thr His Pro Asn Val Asp Lys Lys 
                325                 330                 335     


Leu Phe Thr Ala Glu Ser Leu Ile Gly Leu Lys Asn Pro Glu Lys Ser 
            340                 345                 350         


Phe Pro Val Asn Ser Asp Val Gly Val Leu Lys Trp Arg Leu Gln Thr 
        355                 360                 365             


Thr Glu Glu Ser Phe Ile Pro Leu Thr Ile Asn Cys Trp Pro Ser Glu 
    370                 375                 380                 


Ser Gly Asn Gly Cys Asp Val Asn Ile Glu Tyr Glu Leu Gln Glu Asp 
385                 390                 395                 400 


Asn Leu Glu Leu Asn Asp Val Val Ile Thr Ile Pro Leu Pro Ser Gly 
                405                 410                 415     


Val Gly Ala Pro Val Ile Gly Glu Ile Asp Gly Glu Tyr Arg His Asp 
            420                 425                 430         


Ser Arg Arg Asn Thr Leu Glu Trp Cys Leu Pro Val Ile Asp Ala Lys 
        435                 440                 445             


Asn Lys Ser Gly Ser Leu Glu Phe Ser Ile Ala Gly Gln Pro Asn Asp 
    450                 455                 460                 


Phe Phe Pro Val Gln Val Ser Phe Val Ser Lys Lys Asn Tyr Cys Asn 
465                 470                 475                 480 


Ile Gln Val Thr Lys Val Thr Gln Val Asp Gly Asn Ser Pro Val Arg 
                485                 490                 495     


Phe Ser Thr Glu Thr Thr Phe Leu Val Asp Lys Tyr Glu Ile Leu 
            500                 505                 510     


<210> 203
<211> 3768
<212> DNA
<213> Homo sapiens

<400> 203
gaagacgtgg cttggggccg ccatcttggc aagaggcgaa gcggcagcgg ttcctgtcaa       60

gggggcagca ggtccagagc tgctggtgct cccgttcccc agaccctacc cctatcccca      120

gtggagccgg agtgcgggcg cgccccacca ccgccctcac catgatccct gaatattgcc      180

gagccttaga agagaatgaa atatctgagc actgttttga tttgattttt gcttttgatg      240

aaattgtcgc actgggatac cgggagaatg ttaacttggc acagatcaga accttcacag      300

aaatggattc tcatgaggag aaggtgttca gagccgtcag agagactcaa gaacgtgaag      360

ctaaggctga gatgcgtcgt aaagcaaagg aattacaaca ggcccgaaga gatgcagaga      420

gacagggcaa aaaagcacca ggatttggcg gatttggcag ctctgcagta tctggaggca      480

gcacagctgc catgatcaca gagaccatca ttgaaactga taaaccaaaa gtggcacctg      540

caccagccag gccttcaggc cccagcaagg ctttaaaact tggagccaaa ggaaaggaag      600

tagataactt tgtggacaaa ttaaaatctg aaggtgaaac catcatgtcc tctagtatgg      660

gcaagcgtac ttctgaagca accaaaatgc atgctccacc cattaatatg gaaagtgtac      720

atatgaagat tgaagaaaag ataacattaa cctgtggacg agacggagga ttacagaata      780

tggagttgca tggcatgatc atgcttagga tctcagatga caagtatggc cgaattcgtc      840

ttcatgtgga aaatgaagat aagaaagggg tgcagctaca gacccatcca aatgtggata      900

aaaaactttt cactgcagag tctctaattg gcctgaagaa tccagagaag tcatttccag      960

tcaacagtga cgtaggggtg ctaaagtgga gactacaaac cacagaggaa tcttttattc     1020

cactgacaat taattgctgg ccctcggaga gtggaaatgg ctgtgatgtc aacatagaat     1080

atgagctaca agaagataat ttagaactga atgatgtggt tatcaccatc ccactcccgt     1140

ctggtgtcgg cgcgcctgtt atcggtgaga tcgatgggga gtatcgacat gacagtcgac     1200

gaaataccct ggagtggtgc ctgcctgtga ttgatgccaa aaataagagt ggcagcctgg     1260

agtttagcat tgctgggcag cccaatgact tcttccctgt tcaagtttcc tttgtctcca     1320

agaaaaatta ctgtaacata caggttacca aagtgaccca ggtagatgga aacagccccg     1380

tcaggttttc cacagagacc actttcctag tggataagta tgaaattctg taataccaag     1440

aagagggagc tgaaaaggaa aattttcaga ttaataaaga agacgccaat gatggctgaa     1500

gagtttttcc cagatttaca agccactgga gacccctttt ttctgataca atgcacgatt     1560

ctctgcgcgc aaggaccctc gactcacccc catgtttcag tgtcacagag acattctttg     1620

ataaggaaat ggcacaaaca taaagggaaa ggctgctaat tttctttggc agattgtatt     1680

ggccagcagg aaagcaagct ctccagagaa tgcccccagt taaatacctc ctctaccttt     1740

acctaagttg ctcctttatt tttattttat tattattatt attattatta ttattttttg     1800

agatggagtc tcactttgta acccaggctg gaatgcaatg gcatgatctc agctcactgc     1860

aacctccgcc tcctgggttc aagcaagtct cctgcctcag cctccgagta gctgggacta     1920

caggtgcacg ccaccacgcc tggctaattt tttgtatttt agtagagacg gggtttcacc     1980

gtgttgccca ggctggtcgc gaactcctga gctcaggcaa tccgcccacc tcagcctccc     2040

aaagtgttgg gattacaggc atgagccacc atgcccagct gctcctttat tttaatccct     2100

aaatataatc cctaaatata gttatatttc atacttagtt tgtttttaaa aagttttctc     2160

tgtagaaaat tttaatcatt catacccttt acctttaggt ttttctttct atacattcag     2220

tcaggcactg ggatcatctg tttacaggca ttatatttat ttggcactcc tggaacaagt     2280

atatctaacc cattcttgat ttttggacta ttcaggtgaa ctatttgagg ggtatggggt     2340

ctagaagtta aaagatacgc atgtcttctg ttcttttccc gtatcaattc attccttcat     2400

ctctttgcca agttgttttc ctttcagggc ctgtccttcc agtttagaac agtaccatga     2460

atcccacttg tgtcaatatt aaagatagct gagaagcacc tttcaaatgg cacagtccct     2520

cttcaagatg tctaaaagaa tggttatgtc tgtccagtta gggatttcac atccacatgt     2580

aatcatgtct gctgctgttg ctacccaaat tttcatttct ccacattttg ggtacttaag     2640

ctaaaacgta atggccacag tctgtaatcc attcacattc ctcagtttca ccacctccct     2700

cttccagact gcactctctg tcatcagtcc cctcctttct aacagaaatg gggttatgat     2760

tttgaaggct gtgggttcag ggagtctttg ccaatcctgt tggccctaaa ctatcaagga     2820

ggctccattt caccatttga ttttttgcat ttcaggaggc aactgattgt ttcgatatgt     2880

acatattact cacgtatacc ccatttcctt ccagtcagcc caacattttc caccagtctg     2940

tccccatctc tgaaatcctt ccttctcttt ccccctaagt cttttgagtg tcatcatgta     3000

ctggtggttt ctcggttcca tctcatccat ttccttttca atggagacta cagcgtcagc     3060

cagctcagcc ttggctttta actcaatatt ccagtccata ggggtggtta aaagttgctg     3120

caaggctgca ggcactggca gtgggaagag gcagacgact agatgacttc tgcactttta     3180

gctggttgaa aagtaccact cccactctga acatctggcc gtccctgcaa agagtgtact     3240

gtgcttgaag cagagcactc acacataaat ggctgtgtgt ggaattgctt gccaaagaag     3300

tttctagcct ttccctttcc cctaactgca tcagggaaga attcttatct ctagcttggt     3360

ttccacatga ggtttttctg agaagggctt gggacaagaa gtctgtcatg ttagttaagc     3420

aggcaagaaa tcctactaat ccagttttgt ttgaaagttg tttgtccgta tgatttttta     3480

aaagtcaagt ttaatttcaa aaaacctttt ttttctgaga ttacttttgg ggtaatattt     3540

aaaatgagag acattttgta accctgtaaa atacataggg aatataacat tccagtgtat     3600

acaaagaagg caaattcttt aatcaaataa agcgcattat aaaatgagat gtttattgga     3660

ttattgactc actttggtgt ctgcttgttg attcaggatg ctgtaatggg acctaacatt     3720

aaaaattaat gacatgtttt ttttaagaga aaaaaaaaaa aaaaaaaa                  3768


<210> 204
<211> 423
<212> PRT
<213> Homo sapiens

<400> 204
Met Ile Pro Glu Tyr Cys Arg Ala Leu Glu Glu Asn Glu Ile Ser Glu 
1               5                   10                  15      


His Cys Phe Asp Leu Ile Phe Ala Phe Asp Glu Ile Val Ala Leu Gly 
            20                  25                  30          


Tyr Arg Glu Asn Val Asn Leu Ala Gln Ile Arg Thr Phe Thr Glu Met 
        35                  40                  45              


Asp Ser His Glu Glu Lys Val Phe Arg Ala Val Arg Glu Thr Gln Glu 
    50                  55                  60                  


Arg Glu Ala Lys Ala Glu Met Arg Arg Lys Ala Lys Glu Leu Gln Gln 
65                  70                  75                  80  


Ala Arg Arg Asp Ala Glu Arg Gln Gly Lys Lys Ala Pro Gly Phe Gly 
                85                  90                  95      


Gly Phe Gly Ser Ser Ala Val Ser Gly Gly Ser Thr Ala Ala Met Ile 
            100                 105                 110         


Thr Glu Thr Ile Ile Glu Thr Asp Lys Pro Lys Val Ala Pro Ala Pro 
        115                 120                 125             


Ala Arg Pro Ser Gly Pro Ser Lys Ala Leu Lys Leu Gly Ala Lys Gly 
    130                 135                 140                 


Lys Glu Val Asp Asn Phe Val Asp Lys Leu Lys Ser Glu Gly Glu Thr 
145                 150                 155                 160 


Ile Met Ser Ser Ser Met Gly Lys Arg Thr Ser Glu Ala Thr Lys Met 
                165                 170                 175     


His Ala Pro Pro Ile Asn Met Glu Ser Val His Met Lys Ile Glu Glu 
            180                 185                 190         


Lys Ile Thr Leu Thr Cys Gly Arg Asp Gly Gly Leu Gln Asn Met Glu 
        195                 200                 205             


Leu His Gly Met Ile Met Leu Arg Ile Ser Asp Asp Lys Tyr Gly Arg 
    210                 215                 220                 


Ile Arg Leu His Val Glu Asn Glu Asp Lys Lys Gly Val Gln Leu Gln 
225                 230                 235                 240 


Thr His Pro Asn Val Asp Lys Lys Leu Phe Thr Ala Glu Ser Leu Ile 
                245                 250                 255     


Gly Leu Lys Asn Pro Glu Lys Ser Phe Pro Val Asn Ser Asp Val Gly 
            260                 265                 270         


Val Leu Lys Trp Arg Leu Gln Thr Thr Glu Glu Ser Phe Ile Pro Leu 
        275                 280                 285             


Thr Ile Asn Cys Trp Pro Ser Glu Ser Gly Asn Gly Cys Asp Val Asn 
    290                 295                 300                 


Ile Glu Tyr Glu Leu Gln Glu Asp Asn Leu Glu Leu Asn Asp Val Val 
305                 310                 315                 320 


Ile Thr Ile Pro Leu Pro Ser Gly Val Gly Ala Pro Val Ile Gly Glu 
                325                 330                 335     


Ile Asp Gly Glu Tyr Arg His Asp Ser Arg Arg Asn Thr Leu Glu Trp 
            340                 345                 350         


Cys Leu Pro Val Ile Asp Ala Lys Asn Lys Ser Gly Ser Leu Glu Phe 
        355                 360                 365             


Ser Ile Ala Gly Gln Pro Asn Asp Phe Phe Pro Val Gln Val Ser Phe 
    370                 375                 380                 


Val Ser Lys Lys Asn Tyr Cys Asn Ile Gln Val Thr Lys Val Thr Gln 
385                 390                 395                 400 


Val Asp Gly Asn Ser Pro Val Arg Phe Ser Thr Glu Thr Thr Phe Leu 
                405                 410                 415     


Val Asp Lys Tyr Glu Ile Leu 
            420             


<210> 205
<211> 3790
<212> DNA
<213> Homo sapiens

<400> 205
gccgagctgc gcacgtgcgg ccggaaggga agtaacgtca gcctgagaac tgagtagctg       60

tactgtgtgg cgccttattc taggcacttg ttgggcagaa tgtcacacct gccgatgaaa      120

ctcctgcgta agaagatcga gaagcggaac ctcaaattgc ggcagcggaa cctaaagttt      180

cagggggcct caaatctgac cctatcggaa actcaaaatg gagatgtatc tgaagaaaca      240

atgggaagta gaaaggttaa aaaatcaaaa caaaagccca tgaatgtggg cttatcagaa      300

actcaaaatg gaggcatgtc tcaagaagca gtgggaaata taaaagttac aaagtctccc      360

cagaaatcca ctgtattaac caatggagaa gcagcaatgc agtcttccaa ttcagaatca      420

aaaaagaaaa agaagaaaaa gagaaaaatg gtgaatgatg ctgagcctga tacgaaaaaa      480

gcaaaaactg aaaacaaagg gaaatctgaa gaagaaagtg ccgagactac taaagaaaca      540

gaaaataatg tggagaagcc agataatgat gaagatgaga gtgaggtgcc cagtctgccc      600

ctgggactga caggagcttt tgaggatact tcgtttgctt ctctatgtaa tcttgtcaat      660

gaaaacactc tgaaggcaat aaaagaaatg ggttttacaa acatgactga aattcagcat      720

aaaagtatca gaccacttct ggaaggcagg gatcttctag cagctgcaaa aacaggcagt      780

ggtaaaaccc tggcttttct catccctgca gttgaactca ttgttaagtt aaggttcatg      840

cccaggaatg gaacaggagt ccttattctc tcacctacta gagaactagc catgcaaacc      900

tttggtgttc ttaaggagct gatgactcac cacgtgcata cctatggctt gataatgggt      960

ggcagtaaca gatctgctga agcacagaaa cttggtaatg ggatcaacat cattgtggcc     1020

acaccaggcc gtctgctgga ccatatgcag aataccccag gatttatgta taaaaacctg     1080

cagtgtctgg ttattgatga agctgatcgt atcttggatg tggggtttga agaggaatta     1140

aagcaaatta ttaaactttt gccaacacgt agacagacta tgctcttttc tgccacccaa     1200

actcgaaaag ttgaagacct ggcaaggatt tctctgaaaa aggagccatt gtatgttggc     1260

gttgatgatg ataaagcgaa tgcaacagtg gatggtcttg aacagggata tgttgtttgt     1320

ccttctgaaa agagattcct tctgctcttt acattcctta agaagaaccg aaagaagaag     1380

cttatggtct tcttttcatc ttgtatgtct gtgaaatacc actatgagtt gctgaactac     1440

attgatttgc ccgtcttggc cattcatgga aagcaaaagc aaaataagcg tacaaccaca     1500

ttcttccagt tctgcaatgc agattcggga acactattgt gtacggatgt ggcagcgaga     1560

ggactagaca ttcctgaagt cgactggatt gttcagtatg accctccgga tgaccctaag     1620

gaatatattc atcgtgtggg tagaacagcc agaggcctaa atgggagagg gcatgccttg     1680

ctcattttgc gcccagaaga attgggtttt cttcgctact tgaaacaatc caaggttcca     1740

ttaagtgaat ttgacttttc ctggtctaaa atttctgaca ttcagtctca gcttgagaaa     1800

ttgattgaaa agaattactt tcttcataag tcagcccagg aagcatataa gtcatacata     1860

cgagcctatg attcccattc tctgaaacag atctttaatg ttaataacct aaatttgcct     1920

caggttgctc tgtcatttgg tttcaaggtg cctcccttcg ttgatctgaa cgtcaacagt     1980

aatgaaggca agcagaaaaa gcgaggaggt ggtggtggat ttggctacca gaaaaccaag     2040

aaagttgaga aatccaaaat ctttaaacac attagcaaga aatcatctga cagcaggcag     2100

ttctctcact gaacacatgc cttcctttca tcttgaataa ctttgtccta aaatgaattt     2160

tttttcccct tgatttaaca ggatttttgt agactttaga atttggactt acctaacaag     2220

agtataaatt gacttgggtt gcaagcactg agcactgtta cttctatcac gtctctcttt     2280

tatttctggg atataaaaca ggctttaagt ttcttggttg cccaagggca gagcaaggaa     2340

tatctggtgt ttcttgtgat gataatattt taattttaaa tatccctccc tcatacaagt     2400

gtatgttacc attttaatat aattcttttt gtacctttcc ttcttgtttt gcgaagattt     2460

ttgtggcatg gattgctgtg ctcactgctg taaaaggtga cctagtgtac tgggcagctg     2520

gtggcggtgc agaaaagagt ctcaggttat tttttgtttt tagttatttc ttggaccttg     2580

acagtatcta atgactcctc ctgaaaatgc tgcagtataa aagagcaaag agctttggga     2640

aatacctaag aagcacctta agattagggt ggcattgctt ttatagattc ttgattttaa     2700

agcaacaggc ctttctcagg tgttgcattt tttggagcaa aaactatggg ttgtaatttg     2760

aataaagtgt cactaagcag ttataacgtt tgatggctgg ggggtaggaa gaggatggaa     2820

ttgagatgtt tgagcctcat ttacatcaat agaggtgtaa tgtactgcat ttcttcattt     2880

ggtaacataa caaagacttt catacaaaga acgatgatgc tcctcattaa gatttgttta     2940

attcaaggtg gtttggattt ggtaagcctt tgcactctgt agagtactta gaagacaagg     3000

gcaacttact tggagttaga gccaagctgt cagacggtgc ccagcacaca ttaatgttag     3060

cttctttctg agaaaaaaat acctcttcca ggccctgaaa caaaaaatac atttgctgtg     3120

aagattgaaa atgaacaaag ttagaaaaaa aaacagcaaa atcagtgatt tagtcagatg     3180

agtttttcgt tgtaggagca cttgatttct agtgtgtttt gtacagtata taactacaag     3240

atagtacatt ttgtagcagt tcaaagccaa agttgctagc atcattttgc tgttgtgcca     3300

gttaatcata ggatcccatt aaataagtgt gctaacatcg aatatagaga aaactggtaa     3360

agaacattcc agtaggaaaa gaaaagaaca atcttccatt tctgggcttg gccaccatca     3420

ccctggtcgg acctgtcctg gacttccaac cttgactgct gagctcctgg cttagcttct     3480

tgggttccta attcctggtg tttaataatt ctctccacga tcatgttttt ctgatttttt     3540

ttttcagaaa taatgttttt taaaagacaa aaacaaaggg aagaatattt aattactgag     3600

cagaagtaaa tactgttggc attttgtaca taatctaatt tttatatgca tgttcatgct     3660

ttttaatttt tttatcaaaa attaagtcat ctacctacta cttgtaacca gcttgtttca     3720

taacatgtta ttttcctgtg tcattaaata attacttcaa tgttgaaaaa aaaaaaaaaa     3780

aaaaaaaaaa                                                            3790


<210> 206
<211> 670
<212> PRT
<213> Homo sapiens

<400> 206
Met Ser His Leu Pro Met Lys Leu Leu Arg Lys Lys Ile Glu Lys Arg 
1               5                   10                  15      


Asn Leu Lys Leu Arg Gln Arg Asn Leu Lys Phe Gln Gly Ala Ser Asn 
            20                  25                  30          


Leu Thr Leu Ser Glu Thr Gln Asn Gly Asp Val Ser Glu Glu Thr Met 
        35                  40                  45              


Gly Ser Arg Lys Val Lys Lys Ser Lys Gln Lys Pro Met Asn Val Gly 
    50                  55                  60                  


Leu Ser Glu Thr Gln Asn Gly Gly Met Ser Gln Glu Ala Val Gly Asn 
65                  70                  75                  80  


Ile Lys Val Thr Lys Ser Pro Gln Lys Ser Thr Val Leu Thr Asn Gly 
                85                  90                  95      


Glu Ala Ala Met Gln Ser Ser Asn Ser Glu Ser Lys Lys Lys Lys Lys 
            100                 105                 110         


Lys Lys Arg Lys Met Val Asn Asp Ala Glu Pro Asp Thr Lys Lys Ala 
        115                 120                 125             


Lys Thr Glu Asn Lys Gly Lys Ser Glu Glu Glu Ser Ala Glu Thr Thr 
    130                 135                 140                 


Lys Glu Thr Glu Asn Asn Val Glu Lys Pro Asp Asn Asp Glu Asp Glu 
145                 150                 155                 160 


Ser Glu Val Pro Ser Leu Pro Leu Gly Leu Thr Gly Ala Phe Glu Asp 
                165                 170                 175     


Thr Ser Phe Ala Ser Leu Cys Asn Leu Val Asn Glu Asn Thr Leu Lys 
            180                 185                 190         


Ala Ile Lys Glu Met Gly Phe Thr Asn Met Thr Glu Ile Gln His Lys 
        195                 200                 205             


Ser Ile Arg Pro Leu Leu Glu Gly Arg Asp Leu Leu Ala Ala Ala Lys 
    210                 215                 220                 


Thr Gly Ser Gly Lys Thr Leu Ala Phe Leu Ile Pro Ala Val Glu Leu 
225                 230                 235                 240 


Ile Val Lys Leu Arg Phe Met Pro Arg Asn Gly Thr Gly Val Leu Ile 
                245                 250                 255     


Leu Ser Pro Thr Arg Glu Leu Ala Met Gln Thr Phe Gly Val Leu Lys 
            260                 265                 270         


Glu Leu Met Thr His His Val His Thr Tyr Gly Leu Ile Met Gly Gly 
        275                 280                 285             


Ser Asn Arg Ser Ala Glu Ala Gln Lys Leu Gly Asn Gly Ile Asn Ile 
    290                 295                 300                 


Ile Val Ala Thr Pro Gly Arg Leu Leu Asp His Met Gln Asn Thr Pro 
305                 310                 315                 320 


Gly Phe Met Tyr Lys Asn Leu Gln Cys Leu Val Ile Asp Glu Ala Asp 
                325                 330                 335     


Arg Ile Leu Asp Val Gly Phe Glu Glu Glu Leu Lys Gln Ile Ile Lys 
            340                 345                 350         


Leu Leu Pro Thr Arg Arg Gln Thr Met Leu Phe Ser Ala Thr Gln Thr 
        355                 360                 365             


Arg Lys Val Glu Asp Leu Ala Arg Ile Ser Leu Lys Lys Glu Pro Leu 
    370                 375                 380                 


Tyr Val Gly Val Asp Asp Asp Lys Ala Asn Ala Thr Val Asp Gly Leu 
385                 390                 395                 400 


Glu Gln Gly Tyr Val Val Cys Pro Ser Glu Lys Arg Phe Leu Leu Leu 
                405                 410                 415     


Phe Thr Phe Leu Lys Lys Asn Arg Lys Lys Lys Leu Met Val Phe Phe 
            420                 425                 430         


Ser Ser Cys Met Ser Val Lys Tyr His Tyr Glu Leu Leu Asn Tyr Ile 
        435                 440                 445             


Asp Leu Pro Val Leu Ala Ile His Gly Lys Gln Lys Gln Asn Lys Arg 
    450                 455                 460                 


Thr Thr Thr Phe Phe Gln Phe Cys Asn Ala Asp Ser Gly Thr Leu Leu 
465                 470                 475                 480 


Cys Thr Asp Val Ala Ala Arg Gly Leu Asp Ile Pro Glu Val Asp Trp 
                485                 490                 495     


Ile Val Gln Tyr Asp Pro Pro Asp Asp Pro Lys Glu Tyr Ile His Arg 
            500                 505                 510         


Val Gly Arg Thr Ala Arg Gly Leu Asn Gly Arg Gly His Ala Leu Leu 
        515                 520                 525             


Ile Leu Arg Pro Glu Glu Leu Gly Phe Leu Arg Tyr Leu Lys Gln Ser 
    530                 535                 540                 


Lys Val Pro Leu Ser Glu Phe Asp Phe Ser Trp Ser Lys Ile Ser Asp 
545                 550                 555                 560 


Ile Gln Ser Gln Leu Glu Lys Leu Ile Glu Lys Asn Tyr Phe Leu His 
                565                 570                 575     


Lys Ser Ala Gln Glu Ala Tyr Lys Ser Tyr Ile Arg Ala Tyr Asp Ser 
            580                 585                 590         


His Ser Leu Lys Gln Ile Phe Asn Val Asn Asn Leu Asn Leu Pro Gln 
        595                 600                 605             


Val Ala Leu Ser Phe Gly Phe Lys Val Pro Pro Phe Val Asp Leu Asn 
    610                 615                 620                 


Val Asn Ser Asn Glu Gly Lys Gln Lys Lys Arg Gly Gly Gly Gly Gly 
625                 630                 635                 640 


Phe Gly Tyr Gln Lys Thr Lys Lys Val Glu Lys Ser Lys Ile Phe Lys 
                645                 650                 655     


His Ile Ser Lys Lys Ser Ser Asp Ser Arg Gln Phe Ser His 
            660                 665                 670 


<210> 207
<211> 4410
<212> DNA
<213> Homo sapiens

<400> 207
gtgctcgggg gttccctggc cctttcggca ggggtaaaac aataagaggg ggcggtggca       60

aagggggcgg gacgtccgtg gtccttgtcg cacgtcgcag cgcctggcgc ccgggaagag      120

gtggttgtga ggcagacgaa ctcgcggctc tccggcttcc gaggcttccg agttgtcgga      180

ggaagggggc ggcgagcaat aagaacccgc cgcacccggt cctcagcgac tcttctgacc      240

tccgcgcgac gtacccgccg ccgccgttgg ctggagcatt tgacattgtg cagcaaagaa      300

atggttatgg agaagcccag tccgctgctt gtagggcggg agtttgtgag gcaatattat      360

actttgctga ataaagctcc ggaatattta cacaggtttt atggcaggaa ttcttcctat      420

gttcatggtg gagtagatgc tagtggaaag ccccaggaag ctgtttatgg ccaaaatgat      480

atacaccaca aagtattatc tctgaacttc agtgaatgtc atactaaaat tcgtcatgtg      540

gatgctcatg caaccttgag tgatggagta gttgtccagg tcatgggttt gctgtctaac      600

agtggacaac cagaaagaaa gtttatgcaa acctttgttc tggctcctga aggatctgtt      660

ccaaataaat tttatgttca caatgatatg tttcgttatg aagatgaagt gtttggtgat      720

tctgagcctg aacttgatga agaatcagaa gatgaagtag aagaggaaca agaagaaaga      780

caaccatctc ctgaacctgt gcaagaaaat gctaacagtg gttactatga agctcaccct      840

gtgactaatg gcatagagga gcctttggaa gaatcctctc atgaacctga acctgagcca      900

gaatctgaaa caaagactga agagctgaaa ccacaagtgg aggagaagaa cttagaagaa      960

ctagaggaga aatctactac tcctcctccg gcagaacctg tttctctgcc acaagaacca     1020

ccaaaggctt tctcctgggc ttcagtgacc agtaaaaacc tgcctcctag tggtactgtt     1080

tcttcctctg gaattccacc ccatgttaaa gcaccagtct cacagccaag agtcgaagct     1140

aaaccagaag ttcaatctca gccacctcgt gtgcgtgaac aacgacctag agaacgacct     1200

ggttttcctc ctagaggacc aagaccaggc agaggagata tggaacagaa tgactctgac     1260

aaccgtagaa taattcgcta tccagatagt catcaacttt ttgttggtaa cttgccacat     1320

gatattgatg aaaatgagct aaaggaattc ttcatgagtt ttggaaacgt tgtggaactt     1380

cgcatcaata ccaagggtgt tgggggaaag cttccaaatt ttggttttgt ggtttttgat     1440

gactctgaac cagttcagag aatcttaatt gcaaaaccga ttatgtttcg aggggaagta     1500

cgtttaaatg tggaagagaa aaaaacaaga gctgcaagag agcgagaaac cagaggtggt     1560

ggtgatgatc gcagggatat taggcgcaat gatcgaggtc ccggtggtcc acgtggaatt     1620

gtgggtggtg gaatgatgcg tgatcgtgat ggaagaggac ctcctccaag gggtggcatg     1680

gcacagaaac ttggctctgg aagaggaacc gggcaaatgg agggccgctt cacaggacag     1740

cgtcgctgaa gctccactgt tggcaaagtc ttggcagtgg tacattattc atcgtgtttg     1800

cattcttgtt aatttttttt ttggctttgg aatgtgacac agcctttttg atcatttctt     1860

tgatgtgaaa agcatctttg gttatcagtt aaattgaggt ggacattatt tccccaattt     1920

cacaacagga ttcacattgt taatttataa atctagactt ggagaattaa ggactgagaa     1980

atgaccatat cttaaactat ctacgacaaa gtgaacttaa aaggacatgc ccactgaatt     2040

caggtccttt gagtaaaaaa aaaatcttct gctgcacatt ttgtttaagt gttactgttt     2100

ctgcctgtta atgctgggaa cacaaatagt gcaatttgtg caattggaga atcttgcctt     2160

ttttcttggc tccccccaaa aatacaaacc aacagaaact tgttatgcac tcatcaaaat     2220

gtactaatgg gtactctgaa ctcattaaca ttgacatctg caacaggagg caacagggaa     2280

aaaatctcat cttcttttcc agtagaaaat agtttgtgaa atgatgaggg cattttatct     2340

gcttgctgtg accagcgtgt gtacacataa accttaacaa gactacaagt atattccaga     2400

aggaaatcat tttagttatg aactaaataa taaaaattag aacttcaaat gcgatggtct     2460

tgactattag accagattta gtagctccat atctaagatt tttctacctg cccctcttca     2520

gtacagggat ggctggctgc tcaacacact cctcctcccc ttttttcctt tctttaagct     2580

gtgtacagtg aaaattgtct ttactgtatt tttgttctct ggtaatgtaa taagcatgat     2640

ggtgccttct attaatacat cattccagtc ttgctggtaa ttttgtacag tatagtgtat     2700

gaattgctgt gctgcaaagc caaacagctg caaaatgttg aaaaatcatc gaaatgtata     2760

aaaattgcag tatctttaaa atcagtaaaa tggactagca tattatttat cttgttcttc     2820

agttaacaac tttgtgttct ctgtgggagg gagggagtcc tgtgtgtttg tggggagagg     2880

gaaggaggaa gtcagttatt tgagtaagcc tctagttgac ttttctctta gcctgaatgt     2940

ggacgttgaa acatatcact tcagggcttg gaaaagtcag tcaacttgac gtacattttt     3000

agtgacattt taaaagcagt cagattctat aaatggcaag taagcctgaa gtgaggatac     3060

tgcaattttc ggagaaaaga acagcagctc tttaagtgtt tgcattttct atttgggggg     3120

cagggaactg tcattcattt tgcacaattc ttgaactgat gtcagcaccc gagtggctcc     3180

tgaatttaag tctgggacga catcttttat ttttacatga atctttaaac aattctgtga     3240

gcaaagtttg tagctgctgg attattgtct gtctttatag caagttccag taaaccacaa     3300

gtatggcaaa gcttatccaa ttttatgctt ggagcagtca gtacatacca gtttctgatg     3360

tttcaggcag gagtggggta aataagtgtg accacttaaa gctgctcgtt agcatggaag     3420

acttctccat tctatctttg taaaacagac aagatatgca cttgacatag tagcaaattg     3480

gttctgaatt atgcaactgt ttgctattta gtaaactagc aaatgatgca tgtattttgt     3540

ttttcatgta ctgggcaata tgagtaaaat ctgtcccttt ttcccccttt gaatgaggtc     3600

ttccatgttt gagggaaagt cttgcactat tgcatatatt ttggggacac agattttcat     3660

agtttccatt tttggggggc ttaaggattt tttttttttc tgtttgaaac agttttatac     3720

tttctgatat agtacttgaa attcttacca gaaaattact ttggagtttt gaagccttta     3780

ttaatactac ttttaaagaa gcagttgttt tattgtcaat gttttttttc ccccaagcat     3840

attttcttgt atttctgttt ccatatatat atatatatat ataatttcca attcaggata     3900

ttgccctgcc atccatgaaa actgttctgg caccaaaagt aatgacaaat gttaagtgta     3960

ataatagaaa agtagagcaa agagccattc agcttcagtc tttacatacc atgaataaaa     4020

cattaaaaca tcatatggag aagtttacat ggtgattgtt cacctgcagt actgtggagt     4080

tttaacattt tgtcctcttt tcagtgaaac agagtaaaaa tattcatcta ccattactgt     4140

tatttgctga ttttgtttta ttttttgatg gtaatattct atccttatga cactattgca     4200

accaaattgg ctttaccatc ttggctttag taggtataga agacaatgga ttaccatctt     4260

tattgctgta atgtgttaag cattatatgc tagtagaatc tagtttaatt gtttcaggtg     4320

gaaagtattc tttgagtttc catattgaat gtgtttggac taaacaaaca ataaactact     4380

gatgtctgca gcatttatct atgtccctaa                                      4410


<210> 208
<211> 482
<212> PRT
<213> Homo sapiens

<400> 208
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
    130                 135                 140                 


Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
145                 150                 155                 160 


Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                165                 170                 175     


Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
            180                 185                 190         


Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
        195                 200                 205             


Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
    210                 215                 220                 


Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
225                 230                 235                 240 


Pro Lys Ala Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro 
                245                 250                 255     


Ser Gly Thr Val Ser Ser Ser Gly Ile Pro Pro His Val Lys Ala Pro 
            260                 265                 270         


Val Ser Gln Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro 
        275                 280                 285             


Pro Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro 
    290                 295                 300                 


Arg Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp 
305                 310                 315                 320 


Asn Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly 
                325                 330                 335     


Asn Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met 
            340                 345                 350         


Ser Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly 
        355                 360                 365             


Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
    370                 375                 380                 


Val Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val 
385                 390                 395                 400 


Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu 
                405                 410                 415     


Thr Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg 
            420                 425                 430         


Gly Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp 
        435                 440                 445             


Arg Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu 
    450                 455                 460                 


Gly Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln 
465                 470                 475                 480 


Arg Arg 
        


<210> 209
<211> 4275
<212> DNA
<213> Homo sapiens

<400> 209
acattccatt cgcgctccgc ggcgcgaggc aatcgtccgg tgtgtgagcc cgggagccgg       60

aggtgtagcg gcagagacat tgttcttgcc ggctccctac ggtgccgtgt gtgcgtgaga      120

gaagaccagt ctttcctcta gcatttgaca ttgtgcagca aagaaatggt tatggagaag      180

cccagtccgc tgcttgtagg gcgggagttt gtgaggcaat attatacttt gctgaataaa      240

gctccggaat atttacacag gttttatggc aggaattctt cctatgttca tggtggagta      300

gatgctagtg gaaagcccca ggaagctgtt tatggccaaa atgatataca ccacaaagta      360

ttatctctga acttcagtga atgtcatact aaaattcgtc atgtggatgc tcatgcaacc      420

ttgagtgatg gagtagttgt ccaggtcatg ggtttgctgt ctaacagtgg acaaccagaa      480

agaaagttta tgcaaacctt tgttctggct cctgaaggat ctgttccaaa taaattttat      540

gttcacaatg atatgtttcg ttatgaagat gaagtgtttg gtgattctga gcctgaactt      600

gatgaagaat cagaagatga agtagaagag gaacaagaag aaagacaacc atctcctgaa      660

cctgtgcaag aaaatgctaa cagtggttac tatgaagctc accctgtgac taatggcata      720

gaggagcctt tggaagaatc ctctcatgaa cctgaacctg agccagaatc tgaaacaaag      780

actgaagagc tgaaaccaca agtggaggag aagaacttag aagaactaga ggagaaatct      840

actactcctc ctccggcaga acctgtttct ctgccacaag aaccaccaaa ggctttctcc      900

tgggcttcag tgaccagtaa aaacctgcct cctagtggta ctgtttcttc ctctggaatt      960

ccaccccatg ttaaagcacc agtctcacag ccaagagtcg aagctaaacc agaagttcaa     1020

tctcagccac ctcgtgtgcg tgaacaacga cctagagaac gacctggttt tcctcctaga     1080

ggaccaagac caggcagagg agatatggaa cagaatgact ctgacaaccg tagaataatt     1140

cgctatccag atagtcatca actttttgtt ggtaacttgc cacatgatat tgatgaaaat     1200

gagctaaagg aattcttcat gagttttgga aacgttgtgg aacttcgcat caataccaag     1260

ggtgttgggg gaaagcttcc aaattttggt tttgtggttt ttgatgactc tgaaccagtt     1320

cagagaatct taattgcaaa accgattatg tttcgagggg aagtacgttt aaatgtggaa     1380

gagaaaaaaa caagagctgc aagagagcga gaaaccagag gtggtggtga tgatcgcagg     1440

gatattaggc gcaatgatcg aggtcccggt ggtccacgtg gaattgtggg tggtggaatg     1500

atgcgtgatc gtgatggaag aggacctcct ccaaggggtg gcatggcaca gaaacttggc     1560

tctggaagag gaaccgggca aatggagggc cgcttcacag gacagcgtcg ctgaagctcc     1620

actgttggca aagtcttggc agtggtacat tattcatcgt gtttgcattc ttgttaattt     1680

tttttttggc tttggaatgt gacacagcct ttttgatcat ttctttgatg tgaaaagcat     1740

ctttggttat cagttaaatt gaggtggaca ttatttcccc aatttcacaa caggattcac     1800

attgttaatt tataaatcta gacttggaga attaaggact gagaaatgac catatcttaa     1860

actatctacg acaaagtgaa cttaaaagga catgcccact gaattcaggt cctttgagta     1920

aaaaaaaaat cttctgctgc acattttgtt taagtgttac tgtttctgcc tgttaatgct     1980

gggaacacaa atagtgcaat ttgtgcaatt ggagaatctt gccttttttc ttggctcccc     2040

ccaaaaatac aaaccaacag aaacttgtta tgcactcatc aaaatgtact aatgggtact     2100

ctgaactcat taacattgac atctgcaaca ggaggcaaca gggaaaaaat ctcatcttct     2160

tttccagtag aaaatagttt gtgaaatgat gagggcattt tatctgcttg ctgtgaccag     2220

cgtgtgtaca cataaacctt aacaagacta caagtatatt ccagaaggaa atcattttag     2280

ttatgaacta aataataaaa attagaactt caaatgcgat ggtcttgact attagaccag     2340

atttagtagc tccatatcta agatttttct acctgcccct cttcagtaca gggatggctg     2400

gctgctcaac acactcctcc tccccttttt tcctttcttt aagctgtgta cagtgaaaat     2460

tgtctttact gtatttttgt tctctggtaa tgtaataagc atgatggtgc cttctattaa     2520

tacatcattc cagtcttgct ggtaattttg tacagtatag tgtatgaatt gctgtgctgc     2580

aaagccaaac agctgcaaaa tgttgaaaaa tcatcgaaat gtataaaaat tgcagtatct     2640

ttaaaatcag taaaatggac tagcatatta tttatcttgt tcttcagtta acaactttgt     2700

gttctctgtg ggagggaggg agtcctgtgt gtttgtgggg agagggaagg aggaagtcag     2760

ttatttgagt aagcctctag ttgacttttc tcttagcctg aatgtggacg ttgaaacata     2820

tcacttcagg gcttggaaaa gtcagtcaac ttgacgtaca tttttagtga cattttaaaa     2880

gcagtcagat tctataaatg gcaagtaagc ctgaagtgag gatactgcaa ttttcggaga     2940

aaagaacagc agctctttaa gtgtttgcat tttctatttg gggggcaggg aactgtcatt     3000

cattttgcac aattcttgaa ctgatgtcag cacccgagtg gctcctgaat ttaagtctgg     3060

gacgacatct tttattttta catgaatctt taaacaattc tgtgagcaaa gtttgtagct     3120

gctggattat tgtctgtctt tatagcaagt tccagtaaac cacaagtatg gcaaagctta     3180

tccaatttta tgcttggagc agtcagtaca taccagtttc tgatgtttca ggcaggagtg     3240

gggtaaataa gtgtgaccac ttaaagctgc tcgttagcat ggaagacttc tccattctat     3300

ctttgtaaaa cagacaagat atgcacttga catagtagca aattggttct gaattatgca     3360

actgtttgct atttagtaaa ctagcaaatg atgcatgtat tttgtttttc atgtactggg     3420

caatatgagt aaaatctgtc cctttttccc cctttgaatg aggtcttcca tgtttgaggg     3480

aaagtcttgc actattgcat atattttggg gacacagatt ttcatagttt ccatttttgg     3540

ggggcttaag gatttttttt ttttctgttt gaaacagttt tatactttct gatatagtac     3600

ttgaaattct taccagaaaa ttactttgga gttttgaagc ctttattaat actactttta     3660

aagaagcagt tgttttattg tcaatgtttt ttttccccca agcatatttt cttgtatttc     3720

tgtttccata tatatatata tatatataat ttccaattca ggatattgcc ctgccatcca     3780

tgaaaactgt tctggcacca aaagtaatga caaatgttaa gtgtaataat agaaaagtag     3840

agcaaagagc cattcagctt cagtctttac ataccatgaa taaaacatta aaacatcata     3900

tggagaagtt tacatggtga ttgttcacct gcagtactgt ggagttttaa cattttgtcc     3960

tcttttcagt gaaacagagt aaaaatattc atctaccatt actgttattt gctgattttg     4020

ttttattttt tgatggtaat attctatcct tatgacacta ttgcaaccaa attggcttta     4080

ccatcttggc tttagtaggt atagaagaca atggattacc atctttattg ctgtaatgtg     4140

ttaagcatta tatgctagta gaatctagtt taattgtttc aggtggaaag tattctttga     4200

gtttccatat tgaatgtgtt tggactaaac aaacaataaa ctactgatgt ctgcagcatt     4260

tatctatgtc cctaa                                                      4275


<210> 210
<211> 482
<212> PRT
<213> Homo sapiens

<400> 210
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
    130                 135                 140                 


Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
145                 150                 155                 160 


Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                165                 170                 175     


Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
            180                 185                 190         


Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
        195                 200                 205             


Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
    210                 215                 220                 


Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
225                 230                 235                 240 


Pro Lys Ala Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro 
                245                 250                 255     


Ser Gly Thr Val Ser Ser Ser Gly Ile Pro Pro His Val Lys Ala Pro 
            260                 265                 270         


Val Ser Gln Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro 
        275                 280                 285             


Pro Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro 
    290                 295                 300                 


Arg Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp 
305                 310                 315                 320 


Asn Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly 
                325                 330                 335     


Asn Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met 
            340                 345                 350         


Ser Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly 
        355                 360                 365             


Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
    370                 375                 380                 


Val Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val 
385                 390                 395                 400 


Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu 
                405                 410                 415     


Thr Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg 
            420                 425                 430         


Gly Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp 
        435                 440                 445             


Arg Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu 
    450                 455                 460                 


Gly Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln 
465                 470                 475                 480 


Arg Arg 
        


<210> 211
<211> 4311
<212> DNA
<213> Homo sapiens

<400> 211
gtgctcgggg gttccctggc cctttcggca ggggtaaaac aataagaggg ggcggtggca       60

aagggggcgg gacgtccgtg gtccttgtcg cacgtcgcag cgcctggcgc ccgggaagag      120

gtggttgtga ggcagacgaa ctcgcggctc tccggcttcc gaggcttccg agttgtcgga      180

ggaagggggc ggcgagcaat aagaacccgc cgcacccggt cctcagcgac tcttctgacc      240

tccgcgcgac gtacccgccg ccgccgttgg ctggagcatt tgacattgtg cagcaaagaa      300

atggttatgg agaagcccag tccgctgctt gtagggcggg agtttgtgag gcaatattat      360

actttgctga ataaagctcc ggaatattta cacaggtttt atggcaggaa ttcttcctat      420

gttcatggtg gagtagatgc tagtggaaag ccccaggaag ctgtttatgg ccaaaatgat      480

atacaccaca aagtattatc tctgaacttc agtgaatgtc atactaaaat tcgtcatgtg      540

gatgctcatg caaccttgag tgatggagta gttgtccagg tcatgggttt gctgtctaac      600

agtggacaac cagaaagaaa gtttatgcaa acctttgttc tggctcctga aggatctgtt      660

ccaaataaat tttatgttca caatgatatg tttcgttatg aagatgaagt gtttggtgat      720

tctgagcctg aacttgatga agaatcagaa gatgaagtag aagaggaaca agaagaaaga      780

caaccatctc ctgaacctgt gcaagaaaat gctaacagtg gttactatga agctcaccct      840

gtgactaatg gcatagagga gcctttggaa gaatcctctc atgaacctga acctgagcca      900

gaatctgaaa caaagactga agagctgaaa ccacaagtgg aggagaagaa cttagaagaa      960

ctagaggaga aatctactac tcctcctccg gcagaacctg tttctctgcc acaagaacca     1020

ccaaagccaa gagtcgaagc taaaccagaa gttcaatctc agccacctcg tgtgcgtgaa     1080

caacgaccta gagaacgacc tggttttcct cctagaggac caagaccagg cagaggagat     1140

atggaacaga atgactctga caaccgtaga ataattcgct atccagatag tcatcaactt     1200

tttgttggta acttgccaca tgatattgat gaaaatgagc taaaggaatt cttcatgagt     1260

tttggaaacg ttgtggaact tcgcatcaat accaagggtg ttgggggaaa gcttccaaat     1320

tttggttttg tggtttttga tgactctgaa ccagttcaga gaatcttaat tgcaaaaccg     1380

attatgtttc gaggggaagt acgtttaaat gtggaagaga aaaaaacaag agctgcaaga     1440

gagcgagaaa ccagaggtgg tggtgatgat cgcagggata ttaggcgcaa tgatcgaggt     1500

cccggtggtc cacgtggaat tgtgggtggt ggaatgatgc gtgatcgtga tggaagagga     1560

cctcctccaa ggggtggcat ggcacagaaa cttggctctg gaagaggaac cgggcaaatg     1620

gagggccgct tcacaggaca gcgtcgctga agctccactg ttggcaaagt cttggcagtg     1680

gtacattatt catcgtgttt gcattcttgt taattttttt tttggctttg gaatgtgaca     1740

cagccttttt gatcatttct ttgatgtgaa aagcatcttt ggttatcagt taaattgagg     1800

tggacattat ttccccaatt tcacaacagg attcacattg ttaatttata aatctagact     1860

tggagaatta aggactgaga aatgaccata tcttaaacta tctacgacaa agtgaactta     1920

aaaggacatg cccactgaat tcaggtcctt tgagtaaaaa aaaaatcttc tgctgcacat     1980

tttgtttaag tgttactgtt tctgcctgtt aatgctggga acacaaatag tgcaatttgt     2040

gcaattggag aatcttgcct tttttcttgg ctccccccaa aaatacaaac caacagaaac     2100

ttgttatgca ctcatcaaaa tgtactaatg ggtactctga actcattaac attgacatct     2160

gcaacaggag gcaacaggga aaaaatctca tcttcttttc cagtagaaaa tagtttgtga     2220

aatgatgagg gcattttatc tgcttgctgt gaccagcgtg tgtacacata aaccttaaca     2280

agactacaag tatattccag aaggaaatca ttttagttat gaactaaata ataaaaatta     2340

gaacttcaaa tgcgatggtc ttgactatta gaccagattt agtagctcca tatctaagat     2400

ttttctacct gcccctcttc agtacaggga tggctggctg ctcaacacac tcctcctccc     2460

cttttttcct ttctttaagc tgtgtacagt gaaaattgtc tttactgtat ttttgttctc     2520

tggtaatgta ataagcatga tggtgccttc tattaataca tcattccagt cttgctggta     2580

attttgtaca gtatagtgta tgaattgctg tgctgcaaag ccaaacagct gcaaaatgtt     2640

gaaaaatcat cgaaatgtat aaaaattgca gtatctttaa aatcagtaaa atggactagc     2700

atattattta tcttgttctt cagttaacaa ctttgtgttc tctgtgggag ggagggagtc     2760

ctgtgtgttt gtggggagag ggaaggagga agtcagttat ttgagtaagc ctctagttga     2820

cttttctctt agcctgaatg tggacgttga aacatatcac ttcagggctt ggaaaagtca     2880

gtcaacttga cgtacatttt tagtgacatt ttaaaagcag tcagattcta taaatggcaa     2940

gtaagcctga agtgaggata ctgcaatttt cggagaaaag aacagcagct ctttaagtgt     3000

ttgcattttc tatttggggg gcagggaact gtcattcatt ttgcacaatt cttgaactga     3060

tgtcagcacc cgagtggctc ctgaatttaa gtctgggacg acatctttta tttttacatg     3120

aatctttaaa caattctgtg agcaaagttt gtagctgctg gattattgtc tgtctttata     3180

gcaagttcca gtaaaccaca agtatggcaa agcttatcca attttatgct tggagcagtc     3240

agtacatacc agtttctgat gtttcaggca ggagtggggt aaataagtgt gaccacttaa     3300

agctgctcgt tagcatggaa gacttctcca ttctatcttt gtaaaacaga caagatatgc     3360

acttgacata gtagcaaatt ggttctgaat tatgcaactg tttgctattt agtaaactag     3420

caaatgatgc atgtattttg tttttcatgt actgggcaat atgagtaaaa tctgtccctt     3480

tttccccctt tgaatgaggt cttccatgtt tgagggaaag tcttgcacta ttgcatatat     3540

tttggggaca cagattttca tagtttccat ttttgggggg cttaaggatt tttttttttt     3600

ctgtttgaaa cagttttata ctttctgata tagtacttga aattcttacc agaaaattac     3660

tttggagttt tgaagccttt attaatacta cttttaaaga agcagttgtt ttattgtcaa     3720

tgtttttttt cccccaagca tattttcttg tatttctgtt tccatatata tatatatata     3780

tataatttcc aattcaggat attgccctgc catccatgaa aactgttctg gcaccaaaag     3840

taatgacaaa tgttaagtgt aataatagaa aagtagagca aagagccatt cagcttcagt     3900

ctttacatac catgaataaa acattaaaac atcatatgga gaagtttaca tggtgattgt     3960

tcacctgcag tactgtggag ttttaacatt ttgtcctctt ttcagtgaaa cagagtaaaa     4020

atattcatct accattactg ttatttgctg attttgtttt attttttgat ggtaatattc     4080

tatccttatg acactattgc aaccaaattg gctttaccat cttggcttta gtaggtatag     4140

aagacaatgg attaccatct ttattgctgt aatgtgttaa gcattatatg ctagtagaat     4200

ctagtttaat tgtttcaggt ggaaagtatt ctttgagttt ccatattgaa tgtgtttgga     4260

ctaaacaaac aataaactac tgatgtctgc agcatttatc tatgtcccta a              4311


<210> 212
<211> 449
<212> PRT
<213> Homo sapiens

<400> 212
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
        35                  40                  45              


Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
    50                  55                  60                  


Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
    130                 135                 140                 


Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
145                 150                 155                 160 


Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                165                 170                 175     


Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
            180                 185                 190         


Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
        195                 200                 205             


Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
    210                 215                 220                 


Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
225                 230                 235                 240 


Pro Lys Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro Pro 
                245                 250                 255     


Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro Arg 
            260                 265                 270         


Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp Asn 
        275                 280                 285             


Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly Asn 
    290                 295                 300                 


Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met Ser 
305                 310                 315                 320 


Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly Gly 
                325                 330                 335     


Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro Val 
            340                 345                 350         


Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val Arg 
        355                 360                 365             


Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu Thr 
    370                 375                 380                 


Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg Gly 
385                 390                 395                 400 


Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp Arg 
                405                 410                 415     


Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu Gly 
            420                 425                 430         


Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln Arg 
        435                 440                 445             


Arg 
    


<210> 213
<211> 546
<212> DNA
<213> Homo sapiens

<400> 213
ctgaactggg ttaggtgccg ctgttgctgc tcgtgttgaa tctagaaccg tagccagaca       60

tgggactgga ggacgagcaa aagatgctta ccgaatccgg agatcctgag gaggaggaag      120

aggaagagga ggaattagtg gatcccctaa caacagtgag agagcaatgc gagcagttgg      180

agaaatgtgt aaaggcccgg gagcggctag agctctgtga tgagcgtgta tcctctcgat      240

cacatacaga agaggattgc acggaggagc tctttgactt cttgcatgcg agggaccatt      300

gcgtggccca caaactcttt aacaacttga aataaatgtg tggacttaat tcaccccagt      360

cttcatcatc tgggcatcag aatatttcct tatggttttg gatgtaccat ttgtttctta      420

tttgtgtaac tgtaagttca catgaacctc atgggtttgg cttaggctgg tagcttctat      480

gtaattcgca atgattccat ctaaataaaa gttctatgat ctgcaaaaaa aaaaaaaaaa      540

aaaaaa                                                                 546


<210> 214
<211> 91
<212> PRT
<213> Homo sapiens

<400> 214
Met Gly Leu Glu Asp Glu Gln Lys Met Leu Thr Glu Ser Gly Asp Pro 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu Val Asp Pro Leu Thr Thr 
            20                  25                  30          


Val Arg Glu Gln Cys Glu Gln Leu Glu Lys Cys Val Lys Ala Arg Glu 
        35                  40                  45              


Arg Leu Glu Leu Cys Asp Glu Arg Val Ser Ser Arg Ser His Thr Glu 
    50                  55                  60                  


Glu Asp Cys Thr Glu Glu Leu Phe Asp Phe Leu His Ala Arg Asp His 
65                  70                  75                  80  


Cys Val Ala His Lys Leu Phe Asn Asn Leu Lys 
                85                  90      


<210> 215
<211> 3385
<212> DNA
<213> Homo sapiens

<400> 215
gctctggtgc tgcggctccg ctctcgtcgc aacgagatct ttcgagatct tctccgcccc       60

cgctaccggc gcctcctctg cggccactga gccggagccg gcctgagcag cgctctcggt      120

tgcagtaccc actggaagga cttaggcgct cgcgtggaca ccgcaagccc ctcagtagcc      180

tcggcccaag aggcctgctt tccactcgct agccccgccg ggggtccgtg tcctgtctcg      240

gtggccggac ccgggcccga gcccgagcag tagccggcgc catgtcggtg gtgggcatag      300

acctgggctt ccagagctgc tacgtcgctg tggcccgcgc cggcggcatc gagactatcg      360

ctaatgagta tagcgaccgc tgcacgccgg cttgcatttc ttttggtcct aagaatcgtt      420

caattggagc agcagctaaa agccaggtaa tttctaatgc aaagaacaca gtccaaggat      480

ttaaaagatt ccatggccga gcattctctg atccatttgt ggaggcagaa aaatctaacc      540

ttgcatatga tattgtgcag ttgcctacag gattaacagg tataaaggtg acatatatgg      600

aggaagagcg aaattttacc actgagcaag tgactgccat gcttttgtcc aaactgaagg      660

agacagccga aagtgttctt aagaagcctg tagttgactg tgttgtttcg gttccttgtt      720

tctatactga tgcagaaaga cgatcagtga tggatgcaac acagattgct ggtcttaatt      780

gcttgcgatt aatgaatgaa accactgcag ttgctcttgc atatggaatc tataagcagg      840

atcttcctgc cttagaagag aaaccaagaa atgtagtttt tgtagacatg ggccactctg      900

cttatcaagt ttctgtatgt gcatttaata gaggaaaact gaaagttctg gccactgcat      960

ttgacacgac attgggaggt agaaaatttg atgaagtgtt agtaaatcac ttctgtgaag     1020

aatttgggaa gaaatacaag ctagacatta agtccaaaat ccgtgcatta ttacgactct     1080

ctcaggagtg tgagaaactc aagaaattga tgagtgcaaa tgcttcagat ctccctttga     1140

gcattgaatg ttttatgaat gatgttgatg tatctggaac tatgaataga ggcaaatttc     1200

tggagatgtg caatgatctc ttagctagag tggagccacc acttcgtagt gttttggaac     1260

aaaccaagtt aaagaaagaa gatatttatg cagtggagat agttggtggt gctacacgaa     1320

tccctgcggt aaaagagaag atcagcaaat ttttcggtaa agaacttagt acaacattaa     1380

atgctgatga agctgtcact cgaggctgtg cattgcagtg tgccatctta tcgcctgctt     1440

tcaaagtcag agaattttct atcactgatg tagtaccata tccaatatct ctgagatgga     1500

attctccagc tgaagaaggg tcaagtgact gtgaagtctt ttccaaaaat catgctgctc     1560

ctttctctaa agttcttaca ttttatagaa aggaaccttt cactcttgag gcctactaca     1620

gctctcctca ggatttgccc tatccagatc ctgctatagc tcagttttca gttcagaaag     1680

tcactcctca gtctgatggc tccagttcaa aagtgaaagt caaagttcga gtaaatgtcc     1740

atggcatttt cagtgtgtcc agtgcatctt tagtggaggt tcacaagtct gaggaaaatg     1800

aggagccaat ggaaacagat cagaatgcaa aggaggaaga gaagatgcaa gtggaccagg     1860

aggaaccaca tgttgaagag caacagcagc agacaccagc agaaaataag gcagagtctg     1920

aagaaatgga gacctctcaa gctggatcca aggataaaaa gatggaccaa ccaccccaag     1980

ccaagaaggc aaaagtgaag accagtactg tggacctgcc aatcgagaat cagctattat     2040

ggcagataga cagagagatg ctcaacttgt acattgaaaa tgagggtaag atgatcatgc     2100

aggataaact ggagaaggag cggaatgatg ctaagaacgc agtggaggaa tatgtgtatg     2160

aaatgagaga caagcttagt ggtgaatatg agaagtttgt gagtgaagat gatcgtaaca     2220

gttttacttt gaaactggaa gatactgaaa attggttgta tgaggatgga gaagaccagc     2280

caaagcaagt ttatgttgat aagttggctg aattaaaaaa tctaggtcaa cctattaaga     2340

tacgtttcca ggaatctgaa gaacgaccaa aattatttga agaactaggg aaacagatcc     2400

aacagtatat gaaaataatc agctctttca aaaacaagga ggaccagtat gatcatttgg     2460

atgctgctga catgacaaag gtagaaaaaa gcacaaatga agcaatggag tggatgaata     2520

acaagctaaa tctgcagaac aagcagagtt tgaccatgga tccagttgtc aagtcaaaag     2580

agattgaagc taaaattaag gagctgacaa gtacttgtag ccctataatt tcaaagccca     2640

aacccaaagt ggaacctcca aaagaggaac aaaaaaatgc agagcagaat ggaccagtgg     2700

atggacaagg agacaaccca ggcccccagg ctgctgagca gggtacagac acagctgtgc     2760

cttcggattc agacaagaag cttcctgaaa tggacattga ttgattccaa cacttgtttc     2820

tattaaaaca gactattata aagctttaag ttgtcaactt tgttctaaat atcaactagc     2880

gcaagtgaat actgaagatt tcttagtcag tttttagggg attttcgggg aggggaaata     2940

ggtaatgtat ggagcatttt cacttctaaa tagttagata cagaaattaa gtgcattgta     3000

tctttttcat aatggtacta tttagaagcc cagttagtct tactgagctt atgcttcact     3060

cctttatgtt taaccatgtg tctacaagaa taagtttgtt ttggaaagtt gagctatagc     3120

tacagctcta gctatccagc agacttttca ttatgactta catggcagga gctctaatta     3180

tgctttaaaa atctgttgtg gagattgctt taaatgctcc ctgcctggtg tggggatggg     3240

gtccccctct ttgtgagggc tggagcatgg cacggcatgg attaacacgg cagaggaaca     3300

aaggtgtgct ctgagcttct tcatatttca ccttcaccct cacctgtgtt ctcttccctc     3360

tctcccaata aaagggctcc catta                                           3385


<210> 216
<211> 840
<212> PRT
<213> Homo sapiens

<400> 216
Met Ser Val Val Gly Ile Asp Leu Gly Phe Gln Ser Cys Tyr Val Ala 
1               5                   10                  15      


Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ala Cys Ile Ser Phe Gly Pro Lys Asn Arg Ser Ile 
        35                  40                  45              


Gly Ala Ala Ala Lys Ser Gln Val Ile Ser Asn Ala Lys Asn Thr Val 
    50                  55                  60                  


Gln Gly Phe Lys Arg Phe His Gly Arg Ala Phe Ser Asp Pro Phe Val 
65                  70                  75                  80  


Glu Ala Glu Lys Ser Asn Leu Ala Tyr Asp Ile Val Gln Leu Pro Thr 
                85                  90                  95      


Gly Leu Thr Gly Ile Lys Val Thr Tyr Met Glu Glu Glu Arg Asn Phe 
            100                 105                 110         


Thr Thr Glu Gln Val Thr Ala Met Leu Leu Ser Lys Leu Lys Glu Thr 
        115                 120                 125             


Ala Glu Ser Val Leu Lys Lys Pro Val Val Asp Cys Val Val Ser Val 
    130                 135                 140                 


Pro Cys Phe Tyr Thr Asp Ala Glu Arg Arg Ser Val Met Asp Ala Thr 
145                 150                 155                 160 


Gln Ile Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                165                 170                 175     


Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ala Leu Glu 
            180                 185                 190         


Glu Lys Pro Arg Asn Val Val Phe Val Asp Met Gly His Ser Ala Tyr 
        195                 200                 205             


Gln Val Ser Val Cys Ala Phe Asn Arg Gly Lys Leu Lys Val Leu Ala 
    210                 215                 220                 


Thr Ala Phe Asp Thr Thr Leu Gly Gly Arg Lys Phe Asp Glu Val Leu 
225                 230                 235                 240 


Val Asn His Phe Cys Glu Glu Phe Gly Lys Lys Tyr Lys Leu Asp Ile 
                245                 250                 255     


Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Ser Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Ser Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Val Asp Val Ser Gly Thr Met Asn Arg Gly 
    290                 295                 300                 


Lys Phe Leu Glu Met Cys Asn Asp Leu Leu Ala Arg Val Glu Pro Pro 
305                 310                 315                 320 


Leu Arg Ser Val Leu Glu Gln Thr Lys Leu Lys Lys Glu Asp Ile Tyr 
                325                 330                 335     


Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Lys Ile Ser Lys Phe Phe Gly Lys Glu Leu Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Thr Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Val Val Pro Tyr 
385                 390                 395                 400 


Pro Ile Ser Leu Arg Trp Asn Ser Pro Ala Glu Glu Gly Ser Ser Asp 
                405                 410                 415     


Cys Glu Val Phe Ser Lys Asn His Ala Ala Pro Phe Ser Lys Val Leu 
            420                 425                 430         


Thr Phe Tyr Arg Lys Glu Pro Phe Thr Leu Glu Ala Tyr Tyr Ser Ser 
        435                 440                 445             


Pro Gln Asp Leu Pro Tyr Pro Asp Pro Ala Ile Ala Gln Phe Ser Val 
    450                 455                 460                 


Gln Lys Val Thr Pro Gln Ser Asp Gly Ser Ser Ser Lys Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Val His Gly Ile Phe Ser Val Ser Ser Ala Ser 
                485                 490                 495     


Leu Val Glu Val His Lys Ser Glu Glu Asn Glu Glu Pro Met Glu Thr 
            500                 505                 510         


Asp Gln Asn Ala Lys Glu Glu Glu Lys Met Gln Val Asp Gln Glu Glu 
        515                 520                 525             


Pro His Val Glu Glu Gln Gln Gln Gln Thr Pro Ala Glu Asn Lys Ala 
    530                 535                 540                 


Glu Ser Glu Glu Met Glu Thr Ser Gln Ala Gly Ser Lys Asp Lys Lys 
545                 550                 555                 560 


Met Asp Gln Pro Pro Gln Ala Lys Lys Ala Lys Val Lys Thr Ser Thr 
                565                 570                 575     


Val Asp Leu Pro Ile Glu Asn Gln Leu Leu Trp Gln Ile Asp Arg Glu 
            580                 585                 590         


Met Leu Asn Leu Tyr Ile Glu Asn Glu Gly Lys Met Ile Met Gln Asp 
        595                 600                 605             


Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu Tyr 
    610                 615                 620                 


Val Tyr Glu Met Arg Asp Lys Leu Ser Gly Glu Tyr Glu Lys Phe Val 
625                 630                 635                 640 


Ser Glu Asp Asp Arg Asn Ser Phe Thr Leu Lys Leu Glu Asp Thr Glu 
                645                 650                 655     


Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln Val Tyr Val 
            660                 665                 670         


Asp Lys Leu Ala Glu Leu Lys Asn Leu Gly Gln Pro Ile Lys Ile Arg 
        675                 680                 685             


Phe Gln Glu Ser Glu Glu Arg Pro Lys Leu Phe Glu Glu Leu Gly Lys 
    690                 695                 700                 


Gln Ile Gln Gln Tyr Met Lys Ile Ile Ser Ser Phe Lys Asn Lys Glu 
705                 710                 715                 720 


Asp Gln Tyr Asp His Leu Asp Ala Ala Asp Met Thr Lys Val Glu Lys 
                725                 730                 735     


Ser Thr Asn Glu Ala Met Glu Trp Met Asn Asn Lys Leu Asn Leu Gln 
            740                 745                 750         


Asn Lys Gln Ser Leu Thr Met Asp Pro Val Val Lys Ser Lys Glu Ile 
        755                 760                 765             


Glu Ala Lys Ile Lys Glu Leu Thr Ser Thr Cys Ser Pro Ile Ile Ser 
    770                 775                 780                 


Lys Pro Lys Pro Lys Val Glu Pro Pro Lys Glu Glu Gln Lys Asn Ala 
785                 790                 795                 800 


Glu Gln Asn Gly Pro Val Asp Gly Gln Gly Asp Asn Pro Gly Pro Gln 
                805                 810                 815     


Ala Ala Glu Gln Gly Thr Asp Thr Ala Val Pro Ser Asp Ser Asp Lys 
            820                 825                 830         


Lys Leu Pro Glu Met Asp Ile Asp 
        835                 840 


<210> 217
<211> 1050
<212> DNA
<213> Homo sapiens

<400> 217
gtcgccgcct gacgccgccc gtcgccggca gcgcaggaca cggcgccgag ggtggggcgc       60

gggcgtagtg gcgccgggag tcgcgggtgc gcgcgggccg tgagtgtgcg cttttgagag      120

tcgcggcgga aggagcccgg ccgccgcccg ccggcatgag ctacgaccgc gccatcaccg      180

tcttctcgcc cgacggccac ctcttccaag tggagtacgc gcaggaggcc gtcaagaagg      240

gctcgaccgc ggttggtgtt cgaggaagag acattgttgt tcttggtgtg gagaagaagt      300

cagtggccaa actgcaggat gaaagaacag tgcggaagat ctgtgctttg gatgacaacg      360

tctgcatggc ctttgcaggc ctcaccgccg atgcaaggat agtcatcaac agggcccggg      420

tggagtgcca gagccaccgg ctgactgtgg aggacccggt cactgtggag tacatcaccc      480

gctacatcgc cagtctgaag cagcgttata cgcagagcaa tgggcgcagg ccgtttggca      540

tctctgccct catcgtgggt ttcgactttg atggcactcc taggctctat cagactgacc      600

cctcgggcac ataccatgcc tggaaggcca atgccatagg tcggggtgcc aagtcagtgc      660

gcgagttcct ggagaagaac tatactgacg aagccattga aacagatgat ctgaccatta      720

agctggtgat caaggcactc ctggaagtgg ttcagtcagg tggcaaaaac attgaacttg      780

ctgtcatgag gcgagatcaa tccctcaaga ttttaaatcc tgaagaaatt gagaagtatg      840

ttgctgaaat tgaaaaagaa aaagaagaaa acgaaaagaa gaaacaaaag aaagcatcat      900

gatgaataaa atgtctttgc ttgtaatttt taaattcata tcaatcatgg atgagtctcg      960

atgtgtaggc ctttccattc catttattca cactgagtgt cctacaataa acttccgtat     1020

ttttaacctg ttaaaaaaaa aaaaaaaaaa                                      1050


<210> 218
<211> 248
<212> PRT
<213> Homo sapiens

<400> 218
Met Ser Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly His Leu 
1               5                   10                  15      


Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser Thr Ala 
            20                  25                  30          


Val Gly Val Arg Gly Arg Asp Ile Val Val Leu Gly Val Glu Lys Lys 
        35                  40                  45              


Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile Cys Ala 
    50                  55                  60                  


Leu Asp Asp Asn Val Cys Met Ala Phe Ala Gly Leu Thr Ala Asp Ala 
65                  70                  75                  80  


Arg Ile Val Ile Asn Arg Ala Arg Val Glu Cys Gln Ser His Arg Leu 
                85                  90                  95      


Thr Val Glu Asp Pro Val Thr Val Glu Tyr Ile Thr Arg Tyr Ile Ala 
            100                 105                 110         


Ser Leu Lys Gln Arg Tyr Thr Gln Ser Asn Gly Arg Arg Pro Phe Gly 
        115                 120                 125             


Ile Ser Ala Leu Ile Val Gly Phe Asp Phe Asp Gly Thr Pro Arg Leu 
    130                 135                 140                 


Tyr Gln Thr Asp Pro Ser Gly Thr Tyr His Ala Trp Lys Ala Asn Ala 
145                 150                 155                 160 


Ile Gly Arg Gly Ala Lys Ser Val Arg Glu Phe Leu Glu Lys Asn Tyr 
                165                 170                 175     


Thr Asp Glu Ala Ile Glu Thr Asp Asp Leu Thr Ile Lys Leu Val Ile 
            180                 185                 190         


Lys Ala Leu Leu Glu Val Val Gln Ser Gly Gly Lys Asn Ile Glu Leu 
        195                 200                 205             


Ala Val Met Arg Arg Asp Gln Ser Leu Lys Ile Leu Asn Pro Glu Glu 
    210                 215                 220                 


Ile Glu Lys Tyr Val Ala Glu Ile Glu Lys Glu Lys Glu Glu Asn Glu 
225                 230                 235                 240 


Lys Lys Lys Gln Lys Lys Ala Ser 
                245             


<210> 219
<211> 5905
<212> DNA
<213> Homo sapiens

<400> 219
ctcctcccgc accgccctgt cgcccaacgg cggcctcagg agtgatcggg cagcagtcgg       60

ccggccagcg gacggcagag cgggcggacg ggtaggcccg gcctgctctt cgcgaggagg      120

aagaaggtgg ccactctccc ggtccccaga acctccccag cccccgcagt ccgcccagac      180

cgtaaagggg gacgctgagg agccgcggac gctctccccg gtgccgccgc cgctgccgcc      240

gccatggctg ccatgatgga tcggaagtga gcattagggt taacggctgc cggcgccggc      300

tcttcaagtc ccggctcccc ggccgcctcc acccggggaa gcgcagcgcg gcgcagctga      360

ctgctgcctc tcacggccct cgcgaccaca agccctcagg tccggcgcgt tccctgcaag      420

actgagcggc ggggagtggc tcccggccgc cggccccggc tgcgagaaag atggcggacc      480

tggccgagtg caacatcaaa gtgatgtgtc gcttcagacc tctcaacgag tctgaagtga      540

accgcggcga caagtacatc gccaagtttc agggagaaga cacggtcgtg atcgcgtcca      600

agccttatgc atttgatcgg gtgttccagt caagcacatc tcaagagcaa gtgtataatg      660

actgtgcaaa gaagattgtt aaagatgtac ttgaaggata taatggaaca atatttgcat      720

atggacaaac atcctctggg aagacacaca caatggaggg taaacttcat gatccagaag      780

gcatgggaat tattccaaga atagtgcaag atatttttaa ttatatttac tccatggatg      840

aaaatttgga atttcatatt aaggtttcat attttgaaat atatttggat aagataaggg      900

acctgttaga tgtttcaaag accaaccttt cagttcatga agacaaaaac cgagttccct      960

atgtaaaggg gtgcacagag cgttttgtat gtagtccaga tgaagttatg gataccatag     1020

atgaaggaaa atccaacaga catgtagcag ttacaaatat gaatgaacat agctctagga     1080

gtcacagtat atttcttatt aatgtcaaac aagagaacac acaaacggaa caaaagctga     1140

gtggaaaact ttatctggtt gatttagctg gtagtgaaaa ggttagtaaa actggagctg     1200

aaggtgctgt gctggatgaa gctaaaaaca tcaacaagtc actttctgct cttggaaatg     1260

ttatttctgc tttggctgag ggtagtacat atgttccata tcgagatagt aaaatgacaa     1320

gaatccttca agattcatta ggtggcaact gtagaaccac tattgtaatt tgctgctctc     1380

catcatcata caatgagtct gaaacaaaat ctacactctt atttggccaa agggccaaaa     1440

caattaagaa cacagtttgt gtcaatgtgg agttaactgc agaacagtgg aaaaagaagt     1500

atgaaaaaga aaaagaaaaa aataagatcc tgcggaacac tattcagtgg cttgaaaatg     1560

agctcaacag atggcgtaat ggggagacgg tgcctattga tgaacagttt gacaaagaga     1620

aagccaactt ggaagctttc acagtggata aagatattac tcttaccaat gataaaccag     1680

caaccgcaat tggagttata ggaaatttta ctgatgctga aagaagaaag tgtgaagaag     1740

aaattgctaa attatacaaa cagcttgatg acaaggatga agaaattaac cagcaaagtc     1800

aactggtaga gaaactgaag acgcaaatgt tggatcagga ggagcttttg gcatctacca     1860

gaagggatca agacaatatg caagctgagc tgaatcgcct tcaagcagaa aatgatgcct     1920

ctaaagaaga agtgaaagaa gttttacagg ccctagaaga acttgctgtc aattatgatc     1980

agaagtctca ggaagttgaa gacaaaacta aggaatatga attgcttagt gatgaattga     2040

atcagaaatc ggcaacttta gcgagtatag atgctgagct tcagaaactt aaggaaatga     2100

ccaaccacca gaaaaaacga gcagctgaga tgatggcatc tttactaaaa gaccttgcag     2160

aaataggaat tgctgtggga aataatgatg taaagcagcc tgagggaact ggcatgatag     2220

atgaagagtt cactgttgca agactctaca ttagcaaaat gaagtcagaa gtaaaaacca     2280

tggtgaaacg ttgcaagcag ttagaaagca cacaaactga gagcaacaaa aaaatggaag     2340

aaaatgaaaa ggagttagca gcatgtcagc ttcgtatctc tcaacatgaa gccaaaatca     2400

agtcattgac tgaatacctt caaaatgtgg aacaaaagaa aagacagttg gaggaatctg     2460

tcgatgccct cagtgaagaa ctagtccagc ttcgagcaca agagaaagtc catgaaatgg     2520

aaaaggagca cttaaataag gttcagactg caaatgaagt taagcaagct gttgaacagc     2580

agatccagag ccatagagaa actcatcaaa aacagatcag tagtttgaga gatgaagtag     2640

aagcaaaagc aaaacttatt actgatcttc aagaccaaaa ccagaaaatg atgttagagc     2700

aggaacgtct aagagtagaa catgagaagt tgaaagccac agatcaggaa aagagcagaa     2760

aactacatga acttacggtt atgcaagata gacgagaaca agcaagacaa gacttgaagg     2820

gtttggaaga gacagtggca aaagaacttc agactttaca caacctgcgc aaactctttg     2880

ttcaggacct ggctacaaga gttaaaaaga gtgctgagat tgattctgat gacaccggag     2940

gcagcgctgc tcagaagcaa aaaatctcct ttcttgaaaa taatcttgaa cagctcacta     3000

aagtgcacaa acagttggta cgtgataatg cagatctccg ctgtgaactt cctaagttgg     3060

aaaagcgact tcgagctaca gctgagagag tgaaagcttt ggaatcagca ctgaaagaag     3120

ctaaagaaaa tgcatctcgt gatcgcaaac gctatcagca agaagtagat cgcataaagg     3180

aagcagtcag gtcaaagaat atggccagaa gagggcattc tgcacagatt gctaaaccta     3240

ttcgtcccgg gcaacatcca gcagcttctc caactcaccc aagtgcaatt cgtggaggag     3300

gtgcatttgt tcagaacagc cagccagtgg cagtgcgagg tggaggaggc aaacaagtgt     3360

aatcgtttat acatacccac aggtgttaaa aagtaatcga agtacgaaga ggacatggta     3420

tcaagcagtc attcaatgac tataacctct actcccttgg gattgtagaa ttataacttt     3480

taaaaaaaat gtataaatta tacctggcct gtacagctgt ttcctaccta ctcttcttgt     3540

aaactctgct gcttcccaac acaactagag tgcaattttg gcatcttagg agggaaaaag     3600

gacagtttac aactgtggcc ctatttatta cacagtttgt ctatcgtgtc ttaaatttag     3660

tctttactgt gccaagctaa ctgtacctta taggactgta ctttttgtat tttttgtgta     3720

tgtttatttt ttaatctcag tttaaattac ctagctgcta ctgcttcttg tttttctttt     3780

cctattaaaa cgtcttcctt tttttttctt aagagaaaat ggaacattta ggttaaatgt     3840

ctttaaattt taccacttaa caacactaca tgcccataaa atatatccag tcagtactgt     3900

attttaaaat cccttgaaat gatgatatca gggttaaaat tacttgtatt gtttctgaag     3960

tttgctcctg aaaactactg tttgagcact gaaacgttac aaatgcctaa taggcatttg     4020

agactgagca aggctacttg ttatctcatg aaatgcctgt tgccgagtta ttttgaatag     4080

aaatatttta aagtatcaaa agcagatctt agtttaaggg agtttggaaa aggaattata     4140

tttctctttt tcctgattct gtactcaaca agtcttgatg gaattaaaat actctgcttt     4200

attctggtga gcctgctagc taatataagt attggacagg taataatttg tcatctttaa     4260

tattagtaaa atgaattaag atattatagg attaaacata attttatacg gttagtactt     4320

tattggccga cctaaattta tagcgtgtgg aaattgagaa aaatgaagaa acaggacaga     4380

tatatgatga attaaaaata tatataggtc aattttggtc tgaaatccct gaggtgtttt     4440

taacctgcta cactaatttg tacactaatt tatttcttta gtctagaaat agtaaattgt     4500

ttgcaagtca ctaataatca ttagataaat tattttcttg gccatagccg ataattttgt     4560

aatcagtact aagtgtatac gtatttttgc cactttttcc tcagatgatt aaagtaagtc     4620

aacagcttat tttaggaaac tgtaaaagta atagggaaag agatttcact atttgcttca     4680

tcagtggtag gggggcggtg actgcaactg tgttagcaga aattcacaga gaatggggat     4740

ttaaggttag cagagaaact tggaaagttc tgtgttagga tcttgctggc agaattaact     4800

ttttgcaaaa gttttataca cagatatttg tattaaattt ggagccatag tcagaagact     4860

cagatcataa ttggcttatt tttctatttc cgtaactatt gtaatttcca cttttgtaat     4920

aattttgatt taaaatataa atttatttat ttattttttt aatagtcaaa aatctttgct     4980

gttgtagtct gcaacctcta aaatgattgt gttgctttta ggattgatca gaagaaacac     5040

tccaaaaatt gagatgaaat gttggtgcag ccagttataa gtaatatagt taacaagcaa     5100

aaaaagtgct gccacctttt atgatgattt tctaaatgga gaaacatttg gctgcatcca     5160

catagacctt tatgttttgt tttcagttga aaacttgcct cctttggcaa cattcgtaaa     5220

tgaagcagaa tttttttttc tcttttttcc aaatatgtta gttttgttct tgtaagatgt     5280

atcatgggta ttggtgctgt gtaatgaaca acgaatttta attagcatgt ggttcagaat     5340

atacaatgtt aggtttttaa aaagtatctt gatggttctt ttctatttat aatttcagac     5400

tttcataaag tgtaccaaga atttcataaa tttgttttca gtgaactgct ttttgctatg     5460

gtaggtcatt aaacacagca cttactctta aaaatgaaaa tttctgatca tctaggatat     5520

tgacacattt caatttgcag tgtctttttg actggatata ttaacgttcc tctgaatggc     5580

attgatagat ggttcagaag agaaactcaa tgaaataaag agaatattta ttcatggcga     5640

ttaattaaat tatttgccta acttaagaaa actactgtgc gtaactctca gtttgtgctt     5700

aactccattt gacatgaggt gacagaagag agtctgagtc tacctgtgga atatgttggt     5760

ttattttcag tgcttgaaga tacattcaca aatacttggt ttgggaagac accgtttaat     5820

tttaagttaa cttgcatgtt gtaaatgcgt tttatgttta aataaagagg aaaatttttt     5880

gaaatgtaaa aaaaaaaaaa aaaaa                                           5905


<210> 220
<211> 963
<212> PRT
<213> Homo sapiens

<400> 220
Met Ala Asp Leu Ala Glu Cys Asn Ile Lys Val Met Cys Arg Phe Arg 
1               5                   10                  15      


Pro Leu Asn Glu Ser Glu Val Asn Arg Gly Asp Lys Tyr Ile Ala Lys 
            20                  25                  30          


Phe Gln Gly Glu Asp Thr Val Val Ile Ala Ser Lys Pro Tyr Ala Phe 
        35                  40                  45              


Asp Arg Val Phe Gln Ser Ser Thr Ser Gln Glu Gln Val Tyr Asn Asp 
    50                  55                  60                  


Cys Ala Lys Lys Ile Val Lys Asp Val Leu Glu Gly Tyr Asn Gly Thr 
65                  70                  75                  80  


Ile Phe Ala Tyr Gly Gln Thr Ser Ser Gly Lys Thr His Thr Met Glu 
                85                  90                  95      


Gly Lys Leu His Asp Pro Glu Gly Met Gly Ile Ile Pro Arg Ile Val 
            100                 105                 110         


Gln Asp Ile Phe Asn Tyr Ile Tyr Ser Met Asp Glu Asn Leu Glu Phe 
        115                 120                 125             


His Ile Lys Val Ser Tyr Phe Glu Ile Tyr Leu Asp Lys Ile Arg Asp 
    130                 135                 140                 


Leu Leu Asp Val Ser Lys Thr Asn Leu Ser Val His Glu Asp Lys Asn 
145                 150                 155                 160 


Arg Val Pro Tyr Val Lys Gly Cys Thr Glu Arg Phe Val Cys Ser Pro 
                165                 170                 175     


Asp Glu Val Met Asp Thr Ile Asp Glu Gly Lys Ser Asn Arg His Val 
            180                 185                 190         


Ala Val Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ser Ile Phe 
        195                 200                 205             


Leu Ile Asn Val Lys Gln Glu Asn Thr Gln Thr Glu Gln Lys Leu Ser 
    210                 215                 220                 


Gly Lys Leu Tyr Leu Val Asp Leu Ala Gly Ser Glu Lys Val Ser Lys 
225                 230                 235                 240 


Thr Gly Ala Glu Gly Ala Val Leu Asp Glu Ala Lys Asn Ile Asn Lys 
                245                 250                 255     


Ser Leu Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Ala Glu Gly Ser 
            260                 265                 270         


Thr Tyr Val Pro Tyr Arg Asp Ser Lys Met Thr Arg Ile Leu Gln Asp 
        275                 280                 285             


Ser Leu Gly Gly Asn Cys Arg Thr Thr Ile Val Ile Cys Cys Ser Pro 
    290                 295                 300                 


Ser Ser Tyr Asn Glu Ser Glu Thr Lys Ser Thr Leu Leu Phe Gly Gln 
305                 310                 315                 320 


Arg Ala Lys Thr Ile Lys Asn Thr Val Cys Val Asn Val Glu Leu Thr 
                325                 330                 335     


Ala Glu Gln Trp Lys Lys Lys Tyr Glu Lys Glu Lys Glu Lys Asn Lys 
            340                 345                 350         


Ile Leu Arg Asn Thr Ile Gln Trp Leu Glu Asn Glu Leu Asn Arg Trp 
        355                 360                 365             


Arg Asn Gly Glu Thr Val Pro Ile Asp Glu Gln Phe Asp Lys Glu Lys 
    370                 375                 380                 


Ala Asn Leu Glu Ala Phe Thr Val Asp Lys Asp Ile Thr Leu Thr Asn 
385                 390                 395                 400 


Asp Lys Pro Ala Thr Ala Ile Gly Val Ile Gly Asn Phe Thr Asp Ala 
                405                 410                 415     


Glu Arg Arg Lys Cys Glu Glu Glu Ile Ala Lys Leu Tyr Lys Gln Leu 
            420                 425                 430         


Asp Asp Lys Asp Glu Glu Ile Asn Gln Gln Ser Gln Leu Val Glu Lys 
        435                 440                 445             


Leu Lys Thr Gln Met Leu Asp Gln Glu Glu Leu Leu Ala Ser Thr Arg 
    450                 455                 460                 


Arg Asp Gln Asp Asn Met Gln Ala Glu Leu Asn Arg Leu Gln Ala Glu 
465                 470                 475                 480 


Asn Asp Ala Ser Lys Glu Glu Val Lys Glu Val Leu Gln Ala Leu Glu 
                485                 490                 495     


Glu Leu Ala Val Asn Tyr Asp Gln Lys Ser Gln Glu Val Glu Asp Lys 
            500                 505                 510         


Thr Lys Glu Tyr Glu Leu Leu Ser Asp Glu Leu Asn Gln Lys Ser Ala 
        515                 520                 525             


Thr Leu Ala Ser Ile Asp Ala Glu Leu Gln Lys Leu Lys Glu Met Thr 
    530                 535                 540                 


Asn His Gln Lys Lys Arg Ala Ala Glu Met Met Ala Ser Leu Leu Lys 
545                 550                 555                 560 


Asp Leu Ala Glu Ile Gly Ile Ala Val Gly Asn Asn Asp Val Lys Gln 
                565                 570                 575     


Pro Glu Gly Thr Gly Met Ile Asp Glu Glu Phe Thr Val Ala Arg Leu 
            580                 585                 590         


Tyr Ile Ser Lys Met Lys Ser Glu Val Lys Thr Met Val Lys Arg Cys 
        595                 600                 605             


Lys Gln Leu Glu Ser Thr Gln Thr Glu Ser Asn Lys Lys Met Glu Glu 
    610                 615                 620                 


Asn Glu Lys Glu Leu Ala Ala Cys Gln Leu Arg Ile Ser Gln His Glu 
625                 630                 635                 640 


Ala Lys Ile Lys Ser Leu Thr Glu Tyr Leu Gln Asn Val Glu Gln Lys 
                645                 650                 655     


Lys Arg Gln Leu Glu Glu Ser Val Asp Ala Leu Ser Glu Glu Leu Val 
            660                 665                 670         


Gln Leu Arg Ala Gln Glu Lys Val His Glu Met Glu Lys Glu His Leu 
        675                 680                 685             


Asn Lys Val Gln Thr Ala Asn Glu Val Lys Gln Ala Val Glu Gln Gln 
    690                 695                 700                 


Ile Gln Ser His Arg Glu Thr His Gln Lys Gln Ile Ser Ser Leu Arg 
705                 710                 715                 720 


Asp Glu Val Glu Ala Lys Ala Lys Leu Ile Thr Asp Leu Gln Asp Gln 
                725                 730                 735     


Asn Gln Lys Met Met Leu Glu Gln Glu Arg Leu Arg Val Glu His Glu 
            740                 745                 750         


Lys Leu Lys Ala Thr Asp Gln Glu Lys Ser Arg Lys Leu His Glu Leu 
        755                 760                 765             


Thr Val Met Gln Asp Arg Arg Glu Gln Ala Arg Gln Asp Leu Lys Gly 
    770                 775                 780                 


Leu Glu Glu Thr Val Ala Lys Glu Leu Gln Thr Leu His Asn Leu Arg 
785                 790                 795                 800 


Lys Leu Phe Val Gln Asp Leu Ala Thr Arg Val Lys Lys Ser Ala Glu 
                805                 810                 815     


Ile Asp Ser Asp Asp Thr Gly Gly Ser Ala Ala Gln Lys Gln Lys Ile 
            820                 825                 830         


Ser Phe Leu Glu Asn Asn Leu Glu Gln Leu Thr Lys Val His Lys Gln 
        835                 840                 845             


Leu Val Arg Asp Asn Ala Asp Leu Arg Cys Glu Leu Pro Lys Leu Glu 
    850                 855                 860                 


Lys Arg Leu Arg Ala Thr Ala Glu Arg Val Lys Ala Leu Glu Ser Ala 
865                 870                 875                 880 


Leu Lys Glu Ala Lys Glu Asn Ala Ser Arg Asp Arg Lys Arg Tyr Gln 
                885                 890                 895     


Gln Glu Val Asp Arg Ile Lys Glu Ala Val Arg Ser Lys Asn Met Ala 
            900                 905                 910         


Arg Arg Gly His Ser Ala Gln Ile Ala Lys Pro Ile Arg Pro Gly Gln 
        915                 920                 925             


His Pro Ala Ala Ser Pro Thr His Pro Ser Ala Ile Arg Gly Gly Gly 
    930                 935                 940                 


Ala Phe Val Gln Asn Ser Gln Pro Val Ala Val Arg Gly Gly Gly Gly 
945                 950                 955                 960 


Lys Gln Val 
            


<210> 221
<211> 514
<212> DNA
<213> Homo sapiens

<400> 221
cttccttttt gtccgacatc ttgacgaggc tgcggtgtct gctgctattc tccgagcttc       60

gcaatgccgc ctaaggacga caagaagaag aaggacgctg gaaagtcggc caagaaagac      120

aaagacccag tgaacaaatc cgggggcaag gccaaaaaga agaagtggtc caaaggcaaa      180

gttcgggaca agctcaataa cttagtcttg tttgacaaag ctacctatga taaactctgt      240

aaggaagttc ccaactataa acttataacc ccagctgtgg tctctgagag actgaagatt      300

cgaggctccc tggccagggc agcccttcag gagctcctta gtaaaggact tatcaaactg      360

gtttcaaagc acagagctca agtaatttac accagaaata ccaagggtgg agatgctcca      420

gctgctggtg aagatgcatg aataggtcca accagctgta catttggaaa aataaaactt      480

tattaaatca aaaaaaaaaa aaaaaaaaaa aaaa                                  514


<210> 222
<211> 125
<212> PRT
<213> Homo sapiens

<400> 222
Met Pro Pro Lys Asp Asp Lys Lys Lys Lys Asp Ala Gly Lys Ser Ala 
1               5                   10                  15      


Lys Lys Asp Lys Asp Pro Val Asn Lys Ser Gly Gly Lys Ala Lys Lys 
            20                  25                  30          


Lys Lys Trp Ser Lys Gly Lys Val Arg Asp Lys Leu Asn Asn Leu Val 
        35                  40                  45              


Leu Phe Asp Lys Ala Thr Tyr Asp Lys Leu Cys Lys Glu Val Pro Asn 
    50                  55                  60                  


Tyr Lys Leu Ile Thr Pro Ala Val Val Ser Glu Arg Leu Lys Ile Arg 
65                  70                  75                  80  


Gly Ser Leu Ala Arg Ala Ala Leu Gln Glu Leu Leu Ser Lys Gly Leu 
                85                  90                  95      


Ile Lys Leu Val Ser Lys His Arg Ala Gln Val Ile Tyr Thr Arg Asn 
            100                 105                 110         


Thr Lys Gly Gly Asp Ala Pro Ala Ala Gly Glu Asp Ala 
        115                 120                 125 


<210> 223
<211> 2567
<212> DNA
<213> Homo sapiens

<400> 223
ctccggcgca gtgttgggac tgtctgggta tcggaaagca agcctacgtt gctcactatt       60

acgtataatc cttttctttt caagatgcct gaggaagtgc accatggaga ggaggaggtg      120

gagacttttg cctttcaggc agaaattgcc caactcatgt ccctcatcat caataccttc      180

tattccaaca aggagatttt ccttcgggag ttgatctcta atgcttctga tgccttggac      240

aagattcgct atgagagcct gacagaccct tcgaagttgg acagtggtaa agagctgaaa      300

attgacatca tccccaaccc tcaggaacgt accctgactt tggtagacac aggcattggc      360

atgaccaaag ctgatctcat aaataatttg ggaaccattg ccaagtctgg tactaaagca      420

ttcatggagg ctcttcaggc tggtgcagac atctccatga ttgggcagtt tggtgttggc      480

ttttattctg cctacttggt ggcagagaaa gtggttgtga tcacaaagca caacgatgat      540

gaacagtatg cttgggagtc ttctgctgga ggttccttca ctgtgcgtgc tgaccatggt      600

gagcccattg gcaggggtac caaagtgatc ctccatctta aagaagatca gacagagtac      660

ctagaagaga ggcgggtcaa agaagtagtg aagaagcatt ctcagttcat aggctatccc      720

atcacccttt atttggagaa ggaacgagag aaggaaatta gtgatgatga ggcagaggaa      780

gagaaaggtg agaaagaaga ggaagataaa gatgatgaag aaaaacccaa gatcgaagat      840

gtgggttcag atgaggagga tgacagcggt aaggataaga agaagaaaac taagaagatc      900

aaagagaaat acattgatca ggaagaacta aacaagacca agcctatttg gaccagaaac      960

cctgatgaca tcacccaaga ggagtatgga gaattctaca agagcctcac taatgactgg     1020

gaagaccact tggcagtcaa gcacttttct gtagaaggtc agttggaatt cagggcattg     1080

ctatttattc ctcgtcgggc tccctttgac ctttttgaga acaagaagaa aaagaacaac     1140

atcaaactct atgtccgccg tgtgttcatc atggacagct gtgatgagtt gataccagag     1200

tatctcaatt ttatccgtgg tgtggttgac tctgaggatc tgcccctgaa catctcccga     1260

gaaatgctcc agcagagcaa aatcttgaaa gtcattcgca aaaacattgt taagaagtgc     1320

cttgagctct tctctgagct ggcagaagac aaggagaatt acaagaaatt ctatgaggca     1380

ttctctaaaa atctcaagct tggaatccac gaagactcca ctaaccgccg ccgcctgtct     1440

gagctgctgc gctatcatac ctcccagtct ggagatgaga tgacatctct gtcagagtat     1500

gtttctcgca tgaaggagac acagaagtcc atctattaca tcactggtga gagcaaagag     1560

caggtggcca actcagcttt tgtggagcga gtgcggaaac ggggcttcga ggtggtatat     1620

atgaccgagc ccattgacga gtactgtgtg cagcagctca aggaatttga tgggaagagc     1680

ctggtctcag ttaccaagga gggtctggag ctgcctgagg atgaggagga gaagaagaag     1740

atggaagaga gcaaggcaaa gtttgagaac ctctgcaagc tcatgaaaga aatcttagat     1800

aagaaggttg agaaggtgac aatctccaat agacttgtgt cttcaccttg ctgcattgtg     1860

accagcacct acggctggac agccaatatg gagcggatca tgaaagccca ggcacttcgg     1920

gacaactcca ccatgggcta tatgatggcc aaaaagcacc tggagatcaa ccctgaccac     1980

cccattgtgg agacgctgcg gcagaaggct gaggccgaca agaatgataa ggcagttaag     2040

gacctggtgg tgctgctgtt tgaaaccgcc ctgctatctt ctggcttttc ccttgaggat     2100

ccccagaccc actccaaccg catctatcgc atgatcaagc taggtctagg tattgatgaa     2160

gatgaagtgg cagcagagga acccaatgct gcagttcctg atgagatccc ccctctcgag     2220

ggcgatgagg atgcgtctcg catggaagaa gtcgattagg ttaggagttc atagttggaa     2280

aacttgtgcc cttgtatagt gtccccatgg gctcccactg cagcctcgag tgcccctgtc     2340

ccacctggct ccccctgctg gtgtctagtg tttttttccc tctcctgtcc ttgtgttgaa     2400

ggcagtaaac taagggtgtc aagccccatt ccctctctac tcttgacagc aggattggat     2460

gttgtgtatt gtggtttatt ttattttctt cattttgttc tgaaattaaa gtatgcaaaa     2520

taaagaatat gccgttttaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   2567


<210> 224
<211> 724
<212> PRT
<213> Homo sapiens

<400> 224
Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala 
1               5                   10                  15      


Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe 
            20                  25                  30          


Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser 
        35                  40                  45              


Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys 
    50                  55                  60                  


Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala 
                85                  90                  95      


Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala 
            100                 105                 110         


Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln 
        115                 120                 125             


Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val 
    130                 135                 140                 


Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser 
145                 150                 155                 160 


Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly 
                165                 170                 175     


Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
            180                 185                 190         


Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe 
        195                 200                 205             


Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu 
    210                 215                 220                 


Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu 
225                 230                 235                 240 


Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp 
                245                 250                 255     


Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile 
            260                 265                 270         


Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile 
        275                 280                 285             


Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe 
    290                 295                 300                 


Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His 
305                 310                 315                 320 


Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro 
                325                 330                 335     


Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn 
            340                 345                 350         


Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu 
        355                 360                 365             


Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu 
    370                 375                 380                 


Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile 
385                 390                 395                 400 


Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe 
                405                 410                 415     


Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala 
            420                 425                 430         


Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg 
        435                 440                 445             


Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp 
    450                 455                 460                 


Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln 
465                 470                 475                 480 


Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn 
                485                 490                 495     


Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr 
            500                 505                 510         


Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe 
        515                 520                 525             


Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro 
    530                 535                 540                 


Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe 
545                 550                 555                 560 


Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu 
                565                 570                 575     


Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val 
            580                 585                 590         


Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
        595                 600                 605             


Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys 
    610                 615                 620                 


His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln 
625                 630                 635                 640 


Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val 
                645                 650                 655     


Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp 
            660                 665                 670         


Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu 
        675                 680                 685             


Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val 
    690                 695                 700                 


Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met 
705                 710                 715                 720 


Glu Glu Val Asp 
                


<210> 225
<211> 7253
<212> DNA
<213> Homo sapiens

<400> 225
ggaaagaagt ggaataatta ggaacctagg gtggggtagg gtagcaggac atttcaaaca       60

ttaatgagca tatgagattc caggtcttgt taaaatgcaa attctgattc agctggtagg      120

tgaggtctga gattgtgcat ttctaacaag cactcagata atcttaaggc tgttggcccc      180

agggtcacac ttatagtgat tttctagaac ccagttgggg aagtgaatct tgggcaggag      240

aaatacacac ctcttgcatt gagtttggag atctcatctg atataacttt ttaagaaaga      300

aaaataattt tccaaatatc caattgataa gctttcccac taagtggctt tcccactaag      360

tggctgcgtt atgaaaattg cttcactttg aaacttctgg tcttggtaat atagaatttc      420

tgtgttctca cagtgcttga ttgagaatat gatattgaga ttatggcata aaatatagtg      480

gctgtacaaa aaaaaataca ttattaggat ctctaacaat tatgtaaaag tcattgcttc      540

atgggtagag ctcaaacttt ggtgtgagac ctggttttat tcttggcact tactctgagt      600

tgtcttaggc aaattaatac cttaagcaaa aatattctca tgtacatttt acatgagaat      660

tataaatgaa gtacataaag tccagcagtc acaaatgtta tctattatta ccatcgtcct      720

aagactgcaa tcagctatag tgaaagtagt ctcaaagatt gtttcataaa tcatcagatt      780

cacctaattt tctaaagaat ttaaataagg agatggaatg aatagattgc attttgtttc      840

catgcacagg ggaactgtgc atatttcttc tgtgactcgg aaatggttta acttttaaaa      900

atcccaaaat agctgaagtt agcagacatg caatttacca aggatgattg gaatttttat      960

ctttcctgta ataatactat acccaagcac actgctcatg aggaaaacat ttttatgtga     1020

atcttttact cttgggggca aagaatgctg tttttctttt tgataactat gtttatagaa     1080

tctaaatcac cctgagcaat tatttcaaca tctaaagtta ttattaccat tcatgtttca     1140

tttatagcta tttgaatttt gatgaatttc aatatggtgc tacagtgata gggcaagtgc     1200

aaataagttc aatatatggg tacggtctaa agctatttta atttttttat tacaactgct     1260

atgaagaaaa ttaggatatg ccatattttc acgttttaca gttggatgtc ctatgatgtt     1320

ctcttccaga gaacagagct cggagctctg gaaatttgga ggcaactgat atgtgctcat     1380

gtctgcatct gtgtgggttg gctgtatctc agggacagag tctgcagcaa aaaagatata     1440

attttgagga ctgaacaaaa ttcaggaagg actattctca ttaaggcagt aacagagaag     1500

aattttgaaa caaaagattt tcgagcctct ctagaaaatg gtgttctgct gtgtgatttg     1560

attaataagc ttaaacctgg cgtcattaag aagatcaata gactgtctac accaatagca     1620

ggattggata atataaacgt tttcttgaaa gcttgtgaac agattggatt gaaagaagcc     1680

cagcttttcc atcctggaga tctacaggat ttatcaaatc gagtcactgt caagcaagaa     1740

gagactgaca ggagagtgaa aaatgttttg ataacattgt actggctggg aagaaaagca     1800

caaagcaacc cgtactataa tggtccccat cttaatttga aagcgtttga gaatctttta     1860

ggacaagcac tgacgaaggc actcgaagac tccagcttcc tgaaaagaag tggcagggac     1920

agtggctacg gtgacatctg gtgtcctgaa cgtggagaat ttcttgctcc tccaaggcac     1980

cataagagag aagattcctt tgaaagcttg gactctttgg gctcgaggtc attgacaagc     2040

tgctcctctg atatcacgtt gagagggggg cgtgaaggtt ttgaaagtga cacagattcg     2100

gaatttacat ttaagatgca ggattataat aaagatgata tgtcgtatcg aaggatttcg     2160

gctgttgagc caaagactgc gttacccttc aatcgttttt tacccaacaa aagtagacag     2220

ccatcctatg taccagcacc tctgagaaag aaaaagccag acaaacatga ggataacaga     2280

agaagttggg caagcccggt ttatacagaa gcagatggaa cattttcaag actctttcaa     2340

aagatttatg gtgagaatgg gagtaagtcc atgagtgatg tcagcgcaga agatgttcaa     2400

aacttgcgtc agctgcgtta cgaggagatg cagaaaataa aatcacaatt aaaagaacaa     2460

gatcagaaat ggcaggatga ccttgcaaaa tggaaagatc gtcgaaaaag ttacacttca     2520

gatctgcaga agaaaaaaga agagagagaa gaaattgaaa agcaggcact tgagaagtct     2580

aagagaagct ctaagacgtt taaggaaatg ctgcaggaca gggaatccca aaatcaaaag     2640

tctacagttc cgtcaagaag gagaatgtat tcttttgatg atgtgctgga ggaaggaaag     2700

cgacccccta caatgactgt gtcagaagca agttaccaga gtgagagagt agaagagaag     2760

ggagcaactt atccttcaga aattcccaaa gaagattcta ccacttttgc aaaaagagag     2820

gaccgtgtaa caactgaaat tcagcttcct tctcaaagtc ctgtggaaga acaaagccca     2880

gcctctttgt cttctctgcg ttcacggagc acacaaatgg aatcaactcg tgtttcagct     2940

tctctcccca gaagttaccg gaaaactgat acagtcaggt taacatctgt ggtcacacca     3000

agaccctttg gctctcagac aaggggaatc tcatcactcc ccagatctta cacgatggat     3060

gatgcttgga agtataatgg agatgttgaa gacattaaga gaactccaaa caatgtggtc     3120

agcacccctg caccaagccc ggacgcaagc caactggctt caagcttatc tagccagaaa     3180

gaggtagcag caacagaaga agatgtgaca aggctgccct ctcctacatc ccccttctca     3240

tctctttccc aagaccaggc tgccacttct aaagccacat tgtcttccac atctggtctt     3300

gatttaatgt ctgaatctgg agaaggggaa atctccccac aaagagaagt ctcaagatcc     3360

caggatcagt tcagtgatat gagaatcagc ataaaccaga cgcctgggaa gagtcttgac     3420

tttgggttta caataaaatg ggatattcct gggatcttcg tagcatcagt tgaagcaggt     3480

agcccagcag aattttctca gctacaagta gatgatgaaa ttattgctat taacaacacc     3540

aagttttcat ataacgattc aaaagagtgg gaggaagcca tggctaaggc tcaagaaact     3600

ggacacctag tgatggatgt gaggcgctat ggaaaggctg gttcacctga aacaaagtgg     3660

attgatgcaa cttctggaat ttacaactca gaaaaatctt caaatctatc tgtaacaact     3720

gatttctccg aaagccttca gagttctaat attgaatcca aagaaatcaa tggaattcat     3780

gatgaaagca atgcttttga atcaaaagca tctgaatcca tttctttgaa aaacttaaaa     3840

aggcgatcac aattttttga acaaggaagc tctgattcgg tggttcctga tcttccagtt     3900

ccaaccatca gtgccccgag tcgctgggtg tgggatcaag aggaggagcg gaagcggcag     3960

gagaggtggc agaaggagca ggaccgccta ctgcaggaaa aatatcaacg tgagcaggag     4020

aaactgaggg aagagtggca aagggccaaa caggaggcag agagagagaa ttccaagtac     4080

ttggatgagg aactgatggt cctaagctca aacagcatgt ctctgaccac acgggagccc     4140

tctcttgcca cctgggaagc tacctggagt gaagggtcca agtcttcaga cagagaagga     4200

acccgagcag gagaagagga gaggagacag ccacaagagg aagttgttca tgaggaccaa     4260

ggaaagaagc cgcaggatca gcttgttatt gagagagaga ggaaatggga gcaacagctt     4320

caggaagagc aagagcaaaa gcggcttcag gctgaggctg aggagcagaa gcgtcctgcg     4380

gaggagcaga agcgccaggc agagatagag cgggaaacat cagtcagaat ataccagtac     4440

aggaggcctg ttgattccta tgatatacca aagacagaag aagcatcttc aggttttctt     4500

cctggtgaca ggaataaatc cagatctact actgaactgg atgattactc cacaaataaa     4560

aatggaaaca ataaatattt agaccaaatt gggaacatga cctcttcaca gaggagatcc     4620

aagaaagaac aagtaccatc aggagcagaa ttggagaggc aacaaatcct tcaggaaatg     4680

aggaagagaa caccccttca caatgacaac agctggatcc gacagcgcag tgccagtgtc     4740

aacaaagagc ctgttagtct tcctgggatc atgagaagag gcgaatcttt agataacctg     4800

gactcccccc gatccaattc ttggagacag cctccttggc tcaatcagcc cacaggattc     4860

tatgcttctt cctctgtgca agactttagt cgcccaccac ctcagctggt gtccacatca     4920

aaccgtgcct acatgcggaa cccctcctcc agcgtgcccc caccttcagc tggctccgtg     4980

aagacctcca ccacaggtgt ggccaccaca cagtccccca ccccgagaag ccattcccct     5040

tcagcttcac agtcaggctc tcagctgcgt aacaggtcag tcagtgggaa gcgcatatgc     5100

tcctactgca ataacattct gggcaaagga gccgccatga tcatcgagtc cctgggtctt     5160

tgttatcatt tgcattgttt taagtgtgtt gcctgtgagt gtgacctcgg aggctcttcc     5220

tcaggagctg aagtcaggat cagaaaccac caactgtact gcaacgactg ctatctcaga     5280

ttcaaatctg gacggccaac cgccatgtga tgtaagcctc catacgaaag cactgttgca     5340

gatagaagaa gaggtggttg ctgctcatgt agatctataa atatgtgttg tatgtctttt     5400

ttgctttttt tttaaaaaaa agaataactt tttttgcctc tttagattac atagaagcat     5460

tgtagtcttg gtagaaccag tatttttgtt gtttatttat aaggtaattg tgtgtgggga     5520

aaagtgcagt atttacctgt tgaattcagc atcttgagag cacaagggaa aaaataagaa     5580

cctacgaata tttttgaggc agataatgat ctagtttgac tttctagtta gtggtgtttt     5640

gaagagggta ttttattgtt ttttaaaaaa aggttcttaa acattatttg aaatagttaa     5700

tataaataca taattgcatt tgctctgttt attgtaatgt attctaaatt aatgcagaac     5760

catatggaaa atttcattaa aatctatccc caaatgtgct ttctgtatcc ttccttctac     5820

ctattattct gatttttaaa aatgcagtta atgtaccatt tatttgcttg atgaagggag     5880

ctctattttc tttaccagaa atgttgctaa gtaattccca atagaaagct gcttattttc     5940

attaatgaaa aataaccatg gtttgtatac tagaagtctt cttcagaaac tggtgagcct     6000

ttctgttcaa ttgcatttgt aaataaactt gctgatgcat ttaacgagtg ggtcgtcttt     6060

ttcttaggtg tatgtgtctg acctcaggcc ttttagccat atttcagtat gtggcctttt     6120

ttgatgttat gttttatcca gtagctttac taaggtataa ttgatgtaat aaactgcata     6180

tatttaaagt gtatactttg acaaattttg acatggtgta taccttcgaa actatgccac     6240

agtctggatg tgtttactga aacattttaa taaggaagtt tatttttgat aaagttatgt     6300

ttttggatac aatatatttg tatggtgaga gtgatgaatt gttggatcat ttgaataaaa     6360

tcttttacta accccatgat aaaaggagaa gacaacagtg agcttagaat atctataaag     6420

caaaaaatgt agtctcttgt ttaaaaaatc tggagcggga atgcaaggat acaaaacttt     6480

agcatgcttt gagcaaaaat ttaaacttac tggaatcttt tataataatg taagtggaat     6540

ggaggattct aggaactgag aactgtattg gaataggttc aaaatatgta agaaatgcta     6600

atgtgggaga taaaaatttt atttagtact tattctgatt attattaaag taataatgtg     6660

ttccttgagg ataacttgtc aaatgcccca aagcataaag aatataattc tgaatcccaa     6720

attccaaaga caagaactct gtgtttgaat tcattctgca tataattatt tataagtata     6780

gattgtgaat ttttccatgt tcttaaaatt atttttatct tttttcatgg ttgcatagtg     6840

ctccattgtt tggccttggt aatatttagt tgataattcc attactgtgt atttttcact     6900

tgtttctaag atcaaacatt ttaatatgtg catgttatat ataaatatgt aaattctgtg     6960

atactctatg atcatctctt tctttatatt attttcatag acatgaaata gttgctcaga     7020

gattatgcat tttaagacac tcatagtata tattgccaaa gtggtttcca gaaaggcact     7080

gctggcttcg actcctataa gcagcacgtg ggcttgttca tctcactgca tgtttatgaa     7140

gatacagttc ttttgccttg ttctctgcct gatgtgtatg cagaggcagc cctcaatatg     7200

cagtggttga ataaatgaat gaagaaacca ctatcaaaaa aaaaaaaaaa aaa            7253


<210> 226
<211> 1349
<212> PRT
<213> Homo sapiens

<400> 226
Met Lys Lys Ile Arg Ile Cys His Ile Phe Thr Phe Tyr Ser Trp Met 
1               5                   10                  15      


Ser Tyr Asp Val Leu Phe Gln Arg Thr Glu Leu Gly Ala Leu Glu Ile 
            20                  25                  30          


Trp Arg Gln Leu Ile Cys Ala His Val Cys Ile Cys Val Gly Trp Leu 
        35                  40                  45              


Tyr Leu Arg Asp Arg Val Cys Ser Lys Lys Asp Ile Ile Leu Arg Thr 
    50                  55                  60                  


Glu Gln Asn Ser Gly Arg Thr Ile Leu Ile Lys Ala Val Thr Glu Lys 
65                  70                  75                  80  


Asn Phe Glu Thr Lys Asp Phe Arg Ala Ser Leu Glu Asn Gly Val Leu 
                85                  90                  95      


Leu Cys Asp Leu Ile Asn Lys Leu Lys Pro Gly Val Ile Lys Lys Ile 
            100                 105                 110         


Asn Arg Leu Ser Thr Pro Ile Ala Gly Leu Asp Asn Ile Asn Val Phe 
        115                 120                 125             


Leu Lys Ala Cys Glu Gln Ile Gly Leu Lys Glu Ala Gln Leu Phe His 
    130                 135                 140                 


Pro Gly Asp Leu Gln Asp Leu Ser Asn Arg Val Thr Val Lys Gln Glu 
145                 150                 155                 160 


Glu Thr Asp Arg Arg Val Lys Asn Val Leu Ile Thr Leu Tyr Trp Leu 
                165                 170                 175     


Gly Arg Lys Ala Gln Ser Asn Pro Tyr Tyr Asn Gly Pro His Leu Asn 
            180                 185                 190         


Leu Lys Ala Phe Glu Asn Leu Leu Gly Gln Ala Leu Thr Lys Ala Leu 
        195                 200                 205             


Glu Asp Ser Ser Phe Leu Lys Arg Ser Gly Arg Asp Ser Gly Tyr Gly 
    210                 215                 220                 


Asp Ile Trp Cys Pro Glu Arg Gly Glu Phe Leu Ala Pro Pro Arg His 
225                 230                 235                 240 


His Lys Arg Glu Asp Ser Phe Glu Ser Leu Asp Ser Leu Gly Ser Arg 
                245                 250                 255     


Ser Leu Thr Ser Cys Ser Ser Asp Ile Thr Leu Arg Gly Gly Arg Glu 
            260                 265                 270         


Gly Phe Glu Ser Asp Thr Asp Ser Glu Phe Thr Phe Lys Met Gln Asp 
        275                 280                 285             


Tyr Asn Lys Asp Asp Met Ser Tyr Arg Arg Ile Ser Ala Val Glu Pro 
    290                 295                 300                 


Lys Thr Ala Leu Pro Phe Asn Arg Phe Leu Pro Asn Lys Ser Arg Gln 
305                 310                 315                 320 


Pro Ser Tyr Val Pro Ala Pro Leu Arg Lys Lys Lys Pro Asp Lys His 
                325                 330                 335     


Glu Asp Asn Arg Arg Ser Trp Ala Ser Pro Val Tyr Thr Glu Ala Asp 
            340                 345                 350         


Gly Thr Phe Ser Arg Leu Phe Gln Lys Ile Tyr Gly Glu Asn Gly Ser 
        355                 360                 365             


Lys Ser Met Ser Asp Val Ser Ala Glu Asp Val Gln Asn Leu Arg Gln 
    370                 375                 380                 


Leu Arg Tyr Glu Glu Met Gln Lys Ile Lys Ser Gln Leu Lys Glu Gln 
385                 390                 395                 400 


Asp Gln Lys Trp Gln Asp Asp Leu Ala Lys Trp Lys Asp Arg Arg Lys 
                405                 410                 415     


Ser Tyr Thr Ser Asp Leu Gln Lys Lys Lys Glu Glu Arg Glu Glu Ile 
            420                 425                 430         


Glu Lys Gln Ala Leu Glu Lys Ser Lys Arg Ser Ser Lys Thr Phe Lys 
        435                 440                 445             


Glu Met Leu Gln Asp Arg Glu Ser Gln Asn Gln Lys Ser Thr Val Pro 
    450                 455                 460                 


Ser Arg Arg Arg Met Tyr Ser Phe Asp Asp Val Leu Glu Glu Gly Lys 
465                 470                 475                 480 


Arg Pro Pro Thr Met Thr Val Ser Glu Ala Ser Tyr Gln Ser Glu Arg 
                485                 490                 495     


Val Glu Glu Lys Gly Ala Thr Tyr Pro Ser Glu Ile Pro Lys Glu Asp 
            500                 505                 510         


Ser Thr Thr Phe Ala Lys Arg Glu Asp Arg Val Thr Thr Glu Ile Gln 
        515                 520                 525             


Leu Pro Ser Gln Ser Pro Val Glu Glu Gln Ser Pro Ala Ser Leu Ser 
    530                 535                 540                 


Ser Leu Arg Ser Arg Ser Thr Gln Met Glu Ser Thr Arg Val Ser Ala 
545                 550                 555                 560 


Ser Leu Pro Arg Ser Tyr Arg Lys Thr Asp Thr Val Arg Leu Thr Ser 
                565                 570                 575     


Val Val Thr Pro Arg Pro Phe Gly Ser Gln Thr Arg Gly Ile Ser Ser 
            580                 585                 590         


Leu Pro Arg Ser Tyr Thr Met Asp Asp Ala Trp Lys Tyr Asn Gly Asp 
        595                 600                 605             


Val Glu Asp Ile Lys Arg Thr Pro Asn Asn Val Val Ser Thr Pro Ala 
    610                 615                 620                 


Pro Ser Pro Asp Ala Ser Gln Leu Ala Ser Ser Leu Ser Ser Gln Lys 
625                 630                 635                 640 


Glu Val Ala Ala Thr Glu Glu Asp Val Thr Arg Leu Pro Ser Pro Thr 
                645                 650                 655     


Ser Pro Phe Ser Ser Leu Ser Gln Asp Gln Ala Ala Thr Ser Lys Ala 
            660                 665                 670         


Thr Leu Ser Ser Thr Ser Gly Leu Asp Leu Met Ser Glu Ser Gly Glu 
        675                 680                 685             


Gly Glu Ile Ser Pro Gln Arg Glu Val Ser Arg Ser Gln Asp Gln Phe 
    690                 695                 700                 


Ser Asp Met Arg Ile Ser Ile Asn Gln Thr Pro Gly Lys Ser Leu Asp 
705                 710                 715                 720 


Phe Gly Phe Thr Ile Lys Trp Asp Ile Pro Gly Ile Phe Val Ala Ser 
                725                 730                 735     


Val Glu Ala Gly Ser Pro Ala Glu Phe Ser Gln Leu Gln Val Asp Asp 
            740                 745                 750         


Glu Ile Ile Ala Ile Asn Asn Thr Lys Phe Ser Tyr Asn Asp Ser Lys 
        755                 760                 765             


Glu Trp Glu Glu Ala Met Ala Lys Ala Gln Glu Thr Gly His Leu Val 
    770                 775                 780                 


Met Asp Val Arg Arg Tyr Gly Lys Ala Gly Ser Pro Glu Thr Lys Trp 
785                 790                 795                 800 


Ile Asp Ala Thr Ser Gly Ile Tyr Asn Ser Glu Lys Ser Ser Asn Leu 
                805                 810                 815     


Ser Val Thr Thr Asp Phe Ser Glu Ser Leu Gln Ser Ser Asn Ile Glu 
            820                 825                 830         


Ser Lys Glu Ile Asn Gly Ile His Asp Glu Ser Asn Ala Phe Glu Ser 
        835                 840                 845             


Lys Ala Ser Glu Ser Ile Ser Leu Lys Asn Leu Lys Arg Arg Ser Gln 
    850                 855                 860                 


Phe Phe Glu Gln Gly Ser Ser Asp Ser Val Val Pro Asp Leu Pro Val 
865                 870                 875                 880 


Pro Thr Ile Ser Ala Pro Ser Arg Trp Val Trp Asp Gln Glu Glu Glu 
                885                 890                 895     


Arg Lys Arg Gln Glu Arg Trp Gln Lys Glu Gln Asp Arg Leu Leu Gln 
            900                 905                 910         


Glu Lys Tyr Gln Arg Glu Gln Glu Lys Leu Arg Glu Glu Trp Gln Arg 
        915                 920                 925             


Ala Lys Gln Glu Ala Glu Arg Glu Asn Ser Lys Tyr Leu Asp Glu Glu 
    930                 935                 940                 


Leu Met Val Leu Ser Ser Asn Ser Met Ser Leu Thr Thr Arg Glu Pro 
945                 950                 955                 960 


Ser Leu Ala Thr Trp Glu Ala Thr Trp Ser Glu Gly Ser Lys Ser Ser 
                965                 970                 975     


Asp Arg Glu Gly Thr Arg Ala Gly Glu Glu Glu Arg Arg Gln Pro Gln 
            980                 985                 990         


Glu Glu Val Val His Glu Asp Gln  Gly Lys Lys Pro Gln  Asp Gln Leu 
        995                 1000                 1005             


Val Ile  Glu Arg Glu Arg Lys  Trp Glu Gln Gln Leu  Gln Glu Glu 
    1010                 1015                 1020             


Gln Glu  Gln Lys Arg Leu Gln  Ala Glu Ala Glu Glu  Gln Lys Arg 
    1025                 1030                 1035             


Pro Ala  Glu Glu Gln Lys Arg  Gln Ala Glu Ile Glu  Arg Glu Thr 
    1040                 1045                 1050             


Ser Val  Arg Ile Tyr Gln Tyr  Arg Arg Pro Val Asp  Ser Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Lys Thr Glu Glu Ala  Ser Ser Gly Phe Leu  Pro Gly Asp 
    1070                 1075                 1080             


Arg Asn  Lys Ser Arg Ser Thr  Thr Glu Leu Asp Asp  Tyr Ser Thr 
    1085                 1090                 1095             


Asn Lys  Asn Gly Asn Asn Lys  Tyr Leu Asp Gln Ile  Gly Asn Met 
    1100                 1105                 1110             


Thr Ser  Ser Gln Arg Arg Ser  Lys Lys Glu Gln Val  Pro Ser Gly 
    1115                 1120                 1125             


Ala Glu  Leu Glu Arg Gln Gln  Ile Leu Gln Glu Met  Arg Lys Arg 
    1130                 1135                 1140             


Thr Pro  Leu His Asn Asp Asn  Ser Trp Ile Arg Gln  Arg Ser Ala 
    1145                 1150                 1155             


Ser Val  Asn Lys Glu Pro Val  Ser Leu Pro Gly Ile  Met Arg Arg 
    1160                 1165                 1170             


Gly Glu  Ser Leu Asp Asn Leu  Asp Ser Pro Arg Ser  Asn Ser Trp 
    1175                 1180                 1185             


Arg Gln  Pro Pro Trp Leu Asn  Gln Pro Thr Gly Phe  Tyr Ala Ser 
    1190                 1195                 1200             


Ser Ser  Val Gln Asp Phe Ser  Arg Pro Pro Pro Gln  Leu Val Ser 
    1205                 1210                 1215             


Thr Ser  Asn Arg Ala Tyr Met  Arg Asn Pro Ser Ser  Ser Val Pro 
    1220                 1225                 1230             


Pro Pro  Ser Ala Gly Ser Val  Lys Thr Ser Thr Thr  Gly Val Ala 
    1235                 1240                 1245             


Thr Thr  Gln Ser Pro Thr Pro  Arg Ser His Ser Pro  Ser Ala Ser 
    1250                 1255                 1260             


Gln Ser  Gly Ser Gln Leu Arg  Asn Arg Ser Val Ser  Gly Lys Arg 
    1265                 1270                 1275             


Ile Cys  Ser Tyr Cys Asn Asn  Ile Leu Gly Lys Gly  Ala Ala Met 
    1280                 1285                 1290             


Ile Ile  Glu Ser Leu Gly Leu  Cys Tyr His Leu His  Cys Phe Lys 
    1295                 1300                 1305             


Cys Val  Ala Cys Glu Cys Asp  Leu Gly Gly Ser Ser  Ser Gly Ala 
    1310                 1315                 1320             


Glu Val  Arg Ile Arg Asn His  Gln Leu Tyr Cys Asn  Asp Cys Tyr 
    1325                 1330                 1335             


Leu Arg  Phe Lys Ser Gly Arg  Pro Thr Ala Met 
    1340                 1345                 


<210> 227
<211> 6791
<212> DNA
<213> Homo sapiens

<400> 227
aacaggtaat gtttaacgtg ccagtcacaa agatcacaga aacagtgtat gcccgggcat       60

aagatagcac gactgtgtat gctctggagg actgaaaggc tgtacaagcc ctatgtattt      120

tttttcaaat atacatatgc atgggtcttg ctgctgcctc ttttgctgac tgtaattgga      180

ctttgaagct tcgaagttat atcataaaaa tttgtaacct ttgtctgaga gagagctcag      240

ctaagcaatc actttccact tcttttcaca ggataatata aacgttttct tgaaagcttg      300

tgaacagatt ggattgaaag aagcccagct tttccatcct ggagatctac aggatttatc      360

aaatcgagtc actgtcaagc aagaagagac tgacaggaga gtgaaaaatg ttttgataac      420

attgtactgg ctgggaagaa aagcacaaag caacccgtac tataatggtc cccatcttaa      480

tttgaaagcg tttgagaatc ttttaggaca agcactgacg aaggcactcg aagactccag      540

cttcctgaaa agaagtggca gggacagtgg ctacggtgac atctggtgtc ctgaacgtgg      600

agaatttctt gctcctccaa ggcaccataa gagagaagat tcctttgaaa gcttggactc      660

tttgggctcg aggtcattga caagctgctc ctctgatatc acgttgagag gggggcgtga      720

aggttttgaa agtgacacag attcggaatt tacatttaag atgcaggatt ataataaaga      780

tgatatgtcg tatcgaagga tttcggctgt tgagccaaag actgcgttac ccttcaatcg      840

ttttttaccc aacaaaagta gacagccatc ctatgtacca gcacctctga gaaagaaaaa      900

gccagacaaa catgaggata acagaagaag ttgggcaagc ccggtttata cagaagcaga      960

tggaacattt tcaagtaatc agaggaggat ttggggcacc aatgtggaga actggccaac     1020

tgtacaagga acttcaaagt cctcttgtta tttggaagag gaaaaagcaa agacaagaag     1080

catacccaac attgtaaagg atgatcttta tgtgcgcaag ctcagtccag tcatgccaaa     1140

cccagggaat gcttttgatc agtttcttcc caaatgttgg accccagaag atgtgaactg     1200

gaaaagaata aaaagggaaa cttataagcc atggtataaa gaatttcagg gattcagtca     1260

gtttttactg cttcaggccc tccaaacata ctctgatgac atcttgtctt ctgaaacaca     1320

taccaaaatt gatcccactt ctggcccaag gctcataacc cgcaggaaga atctctctta     1380

tgcaccaggc tatagaagag atgacctcga gatggcagcc ctggatcctg acttagagaa     1440

tgatgatttc tttgtcagaa agactggggc tttccatgca aatccatatg ttctccgagc     1500

ttttgaagac tttagaaagt tctctgagca agatgattct gtagagcgag atataatttt     1560

acagtgtaga gaaggtgaac ttgtacttcc ggatttggaa aaagatgata tgattgttcg     1620

ccgaattcca gcacagaaga aagaagtgcc gctgtctggg gccccagata gataccaccc     1680

agtccctttt cccgaaccct ggactcttcc tccagaaatt caagcaaaat ttctctgtgt     1740

acttgaaagg acatgcccat ccaaagaaaa aagtaatagc tgtagaatat tagttccttc     1800

atatcggcag aagaaagatg acatgctgac acgtaagatt cagtcctgga aactgggaac     1860

taccgtgcct cccatcagtt tcacccctgg cccctgcagt gaggctgact tgaagagatg     1920

ggaggccatc cgggaggcca gcagacttag gcacaagaaa aggctgatgg tggagagact     1980

ctttcaaaag atttatggtg agaatgggag taagtccatg agtgatgtca gcgcagaaga     2040

tgttcaaaac ttgcgtcagc tgcgttacga ggagatgcag aaaataaaat cacaattaaa     2100

agaacaagat cagaaatggc aggatgacct tgcaaaatgg aaagatcgtc gaaaaagtta     2160

cacttcagat ctgcagaaga aaaaagaaga gagagaagaa attgaaaagc aggcacttga     2220

gaagtctaag agaagctcta agacgtttaa ggaaatgctg caggacaggg aatcccaaaa     2280

tcaaaagtct acagttccgt caagaaggag aatgtattct tttgatgatg tgctggagga     2340

aggaaagcga ccccctacaa tgactgtgtc agaagcaagt taccagagtg agagagtaga     2400

agagaaggga gcaacttatc cttcagaaat tcccaaagaa gattctacca cttttgcaaa     2460

aagagaggac cgtgtaacaa ctgaaattca gcttccttct caaagtcctg tggaagaaca     2520

aagcccagcc tctttgtctt ctctgcgttc acggagcaca caaatggaat caactcgtgt     2580

ttcagcttct ctccccagaa gttaccggaa aactgataca gtcaggttaa catctgtggt     2640

cacaccaaga ccctttggct ctcagacaag gggaatctca tcactcccca gatcttacac     2700

gatggatgat gcttggaagt ataatggaga tgttgaagac attaagagaa ctccaaacaa     2760

tgtggtcagc acccctgcac caagcccgga cgcaagccaa ctggcttcaa gcttatctag     2820

ccagaaagag gtagcagcaa cagaagaaga tgtgacaagg ctgccctctc ctacatcccc     2880

cttctcatct ctttcccaag accaggctgc cacttctaaa gccacattgt cttccacatc     2940

tggtcttgat ttaatgtctg aatctggaga aggggaaatc tccccacaaa gagaagtctc     3000

aagatcccag gatcagttca gtgatatgag aatcagcata aaccagacgc ctgggaagag     3060

tcttgacttt gggtttacaa taaaatggga tattcctggg atcttcgtag catcagttga     3120

agcaggtagc ccagcagaat tttctcagct acaagtagat gatgaaatta ttgctattaa     3180

caacaccaag ttttcatata acgattcaaa agagtgggag gaagccatgg ctaaggctca     3240

agaaactgga cacctagtga tggatgtgag gcgctatgga aaggctggtt cacctgaaac     3300

aaagtggatt gatgcaactt ctggaattta caactcagaa aaatcttcaa atctatctgt     3360

aacaactgat ttctccgaaa gccttcagag ttctaatatt gaatccaaag aaatcaatgg     3420

aattcatgat gaaagcaatg cttttgaatc aaaagcatct gaatccattt ctttgaaaaa     3480

cttaaaaagg cgatcacaat tttttgaaca aggaagctct gattcggtgg ttcctgatct     3540

tccagttcca accatcagtg ccccgagtcg ctgggtgtgg gatcaagagg aggagcggaa     3600

gcggcaggag aggtggcaga aggagcagga ccgcctactg caggaaaaat atcaacgtga     3660

gcaggagaaa ctgagggaag agtggcaaag ggccaaacag gaggcagaga gagagaattc     3720

caagtacttg gatgaggaac tgatggtcct aagctcaaac agcatgtctc tgaccacacg     3780

ggagccctct cttgccacct gggaagctac ctggagtgaa gggtccaagt cttcagacag     3840

agaaggaacc cgagcaggag aagaggagag gagacagcca caagaggaag ttgttcatga     3900

ggaccaagga aagaagccgc aggatcagct tgttattgag agagagagga aatgggagca     3960

acagcttcag gaagagcaag agcaaaagcg gcttcaggct gaggctgagg agcagaagcg     4020

tcctgcggag gagcagaagc gccaggcaga gatagagcgg gaaacatcag tcagaatata     4080

ccagtacagg aggcctgttg attcctatga tataccaaag acagaagaag catcttcagg     4140

ttttcttcct ggtgacagga ataaatccag atctactact gaactggatg attactccac     4200

aaataaaaat ggaaacaata aatatttaga ccaaattggg aacatgacct cttcacagag     4260

gagatccaag aaagaacaag taccatcagg agcagaattg gagaggcaac aaatccttca     4320

ggaaatgagg aagagaacac cccttcacaa tgacaacagc tggatccgac agcgcagtgc     4380

cagtgtcaac aaagagcctg ttagtcttcc tgggatcatg agaagaggcg aatctttaga     4440

taacctggac tccccccgat ccaattcttg gagacagcct ccttggctca atcagcccac     4500

aggattctat gcttcttcct ctgtgcaaga ctttagtcgc ccaccacctc agctggtgtc     4560

cacatcaaac cgtgcctaca tgcggaaccc ctcctccagc gtgcccccac cttcagctgg     4620

ctccgtgaag acctccacca caggtgtggc caccacacag tcccccaccc cgagaagcca     4680

ttccccttca gcttcacagt caggctctca gctgcgtaac agtgtgttgc ctgtgagtgt     4740

gacctcggag gctcttcctc aggagctgaa gtcaggatca gaaaccacca actgtactgc     4800

aacgactgct atctcagatt caaatctgga cggccaaccg ccatgtgatg taagcctcca     4860

tacgaaagca ctgttgcaga tagaagaaga ggtggttgct gctcatgtag atctataaat     4920

atgtgttgta tgtctttttt gctttttttt taaaaaaaag aataactttt tttgcctctt     4980

tagattacat agaagcattg tagtcttggt agaaccagta tttttgttgt ttatttataa     5040

ggtaattgtg tgtggggaaa agtgcagtat ttacctgttg aattcagcat cttgagagca     5100

caagggaaaa aataagaacc tacgaatatt tttgaggcag ataatgatct agtttgactt     5160

tctagttagt ggtgttttga agagggtatt ttattgtttt ttaaaaaaag gttcttaaac     5220

attatttgaa atagttaata taaatacata attgcatttg ctctgtttat tgtaatgtat     5280

tctaaattaa tgcagaacca tatggaaaat ttcattaaaa tctatcccca aatgtgcttt     5340

ctgtatcctt ccttctacct attattctga tttttaaaaa tgcagttaat gtaccattta     5400

tttgcttgat gaagggagct ctattttctt taccagaaat gttgctaagt aattcccaat     5460

agaaagctgc ttattttcat taatgaaaaa taaccatggt ttgtatacta gaagtcttct     5520

tcagaaactg gtgagccttt ctgttcaatt gcatttgtaa ataaacttgc tgatgcattt     5580

aacgagtggg tcgtcttttt cttaggtgta tgtgtctgac ctcaggcctt ttagccatat     5640

ttcagtatgt ggcctttttt gatgttatgt tttatccagt agctttacta aggtataatt     5700

gatgtaataa actgcatata tttaaagtgt atactttgac aaattttgac atggtgtata     5760

ccttcgaaac tatgccacag tctggatgtg tttactgaaa cattttaata aggaagttta     5820

tttttgataa agttatgttt ttggatacaa tatatttgta tggtgagagt gatgaattgt     5880

tggatcattt gaataaaatc ttttactaac cccatgataa aaggagaaga caacagtgag     5940

cttagaatat ctataaagca aaaaatgtag tctcttgttt aaaaaatctg gagcgggaat     6000

gcaaggatac aaaactttag catgctttga gcaaaaattt aaacttactg gaatctttta     6060

taataatgta agtggaatgg aggattctag gaactgagaa ctgtattgga ataggttcaa     6120

aatatgtaag aaatgctaat gtgggagata aaaattttat ttagtactta ttctgattat     6180

tattaaagta ataatgtgtt ccttgaggat aacttgtcaa atgccccaaa gcataaagaa     6240

tataattctg aatcccaaat tccaaagaca agaactctgt gtttgaattc attctgcata     6300

taattattta taagtataga ttgtgaattt ttccatgttc ttaaaattat ttttatcttt     6360

tttcatggtt gcatagtgct ccattgtttg gccttggtaa tatttagttg ataattccat     6420

tactgtgtat ttttcacttg tttctaagat caaacatttt aatatgtgca tgttatatat     6480

aaatatgtaa attctgtgat actctatgat catctctttc tttatattat tttcatagac     6540

atgaaatagt tgctcagaga ttatgcattt taagacactc atagtatata ttgccaaagt     6600

ggtttccaga aaggcactgc tggcttcgac tcctataagc agcacgtggg cttgttcatc     6660

tcactgcatg tttatgaaga tacagttctt ttgccttgtt ctctgcctga tgtgtatgca     6720

gaggcagccc tcaatatgca gtggttgaat aaatgaatga agaaaccact atcaaaaaaa     6780

aaaaaaaaaa a                                                          6791


<210> 228
<211> 1385
<212> PRT
<213> Homo sapiens

<400> 228
Met Gln Asp Tyr Asn Lys Asp Asp Met Ser Tyr Arg Arg Ile Ser Ala 
1               5                   10                  15      


Val Glu Pro Lys Thr Ala Leu Pro Phe Asn Arg Phe Leu Pro Asn Lys 
            20                  25                  30          


Ser Arg Gln Pro Ser Tyr Val Pro Ala Pro Leu Arg Lys Lys Lys Pro 
        35                  40                  45              


Asp Lys His Glu Asp Asn Arg Arg Ser Trp Ala Ser Pro Val Tyr Thr 
    50                  55                  60                  


Glu Ala Asp Gly Thr Phe Ser Ser Asn Gln Arg Arg Ile Trp Gly Thr 
65                  70                  75                  80  


Asn Val Glu Asn Trp Pro Thr Val Gln Gly Thr Ser Lys Ser Ser Cys 
                85                  90                  95      


Tyr Leu Glu Glu Glu Lys Ala Lys Thr Arg Ser Ile Pro Asn Ile Val 
            100                 105                 110         


Lys Asp Asp Leu Tyr Val Arg Lys Leu Ser Pro Val Met Pro Asn Pro 
        115                 120                 125             


Gly Asn Ala Phe Asp Gln Phe Leu Pro Lys Cys Trp Thr Pro Glu Asp 
    130                 135                 140                 


Val Asn Trp Lys Arg Ile Lys Arg Glu Thr Tyr Lys Pro Trp Tyr Lys 
145                 150                 155                 160 


Glu Phe Gln Gly Phe Ser Gln Phe Leu Leu Leu Gln Ala Leu Gln Thr 
                165                 170                 175     


Tyr Ser Asp Asp Ile Leu Ser Ser Glu Thr His Thr Lys Ile Asp Pro 
            180                 185                 190         


Thr Ser Gly Pro Arg Leu Ile Thr Arg Arg Lys Asn Leu Ser Tyr Ala 
        195                 200                 205             


Pro Gly Tyr Arg Arg Asp Asp Leu Glu Met Ala Ala Leu Asp Pro Asp 
    210                 215                 220                 


Leu Glu Asn Asp Asp Phe Phe Val Arg Lys Thr Gly Ala Phe His Ala 
225                 230                 235                 240 


Asn Pro Tyr Val Leu Arg Ala Phe Glu Asp Phe Arg Lys Phe Ser Glu 
                245                 250                 255     


Gln Asp Asp Ser Val Glu Arg Asp Ile Ile Leu Gln Cys Arg Glu Gly 
            260                 265                 270         


Glu Leu Val Leu Pro Asp Leu Glu Lys Asp Asp Met Ile Val Arg Arg 
        275                 280                 285             


Ile Pro Ala Gln Lys Lys Glu Val Pro Leu Ser Gly Ala Pro Asp Arg 
    290                 295                 300                 


Tyr His Pro Val Pro Phe Pro Glu Pro Trp Thr Leu Pro Pro Glu Ile 
305                 310                 315                 320 


Gln Ala Lys Phe Leu Cys Val Leu Glu Arg Thr Cys Pro Ser Lys Glu 
                325                 330                 335     


Lys Ser Asn Ser Cys Arg Ile Leu Val Pro Ser Tyr Arg Gln Lys Lys 
            340                 345                 350         


Asp Asp Met Leu Thr Arg Lys Ile Gln Ser Trp Lys Leu Gly Thr Thr 
        355                 360                 365             


Val Pro Pro Ile Ser Phe Thr Pro Gly Pro Cys Ser Glu Ala Asp Leu 
    370                 375                 380                 


Lys Arg Trp Glu Ala Ile Arg Glu Ala Ser Arg Leu Arg His Lys Lys 
385                 390                 395                 400 


Arg Leu Met Val Glu Arg Leu Phe Gln Lys Ile Tyr Gly Glu Asn Gly 
                405                 410                 415     


Ser Lys Ser Met Ser Asp Val Ser Ala Glu Asp Val Gln Asn Leu Arg 
            420                 425                 430         


Gln Leu Arg Tyr Glu Glu Met Gln Lys Ile Lys Ser Gln Leu Lys Glu 
        435                 440                 445             


Gln Asp Gln Lys Trp Gln Asp Asp Leu Ala Lys Trp Lys Asp Arg Arg 
    450                 455                 460                 


Lys Ser Tyr Thr Ser Asp Leu Gln Lys Lys Lys Glu Glu Arg Glu Glu 
465                 470                 475                 480 


Ile Glu Lys Gln Ala Leu Glu Lys Ser Lys Arg Ser Ser Lys Thr Phe 
                485                 490                 495     


Lys Glu Met Leu Gln Asp Arg Glu Ser Gln Asn Gln Lys Ser Thr Val 
            500                 505                 510         


Pro Ser Arg Arg Arg Met Tyr Ser Phe Asp Asp Val Leu Glu Glu Gly 
        515                 520                 525             


Lys Arg Pro Pro Thr Met Thr Val Ser Glu Ala Ser Tyr Gln Ser Glu 
    530                 535                 540                 


Arg Val Glu Glu Lys Gly Ala Thr Tyr Pro Ser Glu Ile Pro Lys Glu 
545                 550                 555                 560 


Asp Ser Thr Thr Phe Ala Lys Arg Glu Asp Arg Val Thr Thr Glu Ile 
                565                 570                 575     


Gln Leu Pro Ser Gln Ser Pro Val Glu Glu Gln Ser Pro Ala Ser Leu 
            580                 585                 590         


Ser Ser Leu Arg Ser Arg Ser Thr Gln Met Glu Ser Thr Arg Val Ser 
        595                 600                 605             


Ala Ser Leu Pro Arg Ser Tyr Arg Lys Thr Asp Thr Val Arg Leu Thr 
    610                 615                 620                 


Ser Val Val Thr Pro Arg Pro Phe Gly Ser Gln Thr Arg Gly Ile Ser 
625                 630                 635                 640 


Ser Leu Pro Arg Ser Tyr Thr Met Asp Asp Ala Trp Lys Tyr Asn Gly 
                645                 650                 655     


Asp Val Glu Asp Ile Lys Arg Thr Pro Asn Asn Val Val Ser Thr Pro 
            660                 665                 670         


Ala Pro Ser Pro Asp Ala Ser Gln Leu Ala Ser Ser Leu Ser Ser Gln 
        675                 680                 685             


Lys Glu Val Ala Ala Thr Glu Glu Asp Val Thr Arg Leu Pro Ser Pro 
    690                 695                 700                 


Thr Ser Pro Phe Ser Ser Leu Ser Gln Asp Gln Ala Ala Thr Ser Lys 
705                 710                 715                 720 


Ala Thr Leu Ser Ser Thr Ser Gly Leu Asp Leu Met Ser Glu Ser Gly 
                725                 730                 735     


Glu Gly Glu Ile Ser Pro Gln Arg Glu Val Ser Arg Ser Gln Asp Gln 
            740                 745                 750         


Phe Ser Asp Met Arg Ile Ser Ile Asn Gln Thr Pro Gly Lys Ser Leu 
        755                 760                 765             


Asp Phe Gly Phe Thr Ile Lys Trp Asp Ile Pro Gly Ile Phe Val Ala 
    770                 775                 780                 


Ser Val Glu Ala Gly Ser Pro Ala Glu Phe Ser Gln Leu Gln Val Asp 
785                 790                 795                 800 


Asp Glu Ile Ile Ala Ile Asn Asn Thr Lys Phe Ser Tyr Asn Asp Ser 
                805                 810                 815     


Lys Glu Trp Glu Glu Ala Met Ala Lys Ala Gln Glu Thr Gly His Leu 
            820                 825                 830         


Val Met Asp Val Arg Arg Tyr Gly Lys Ala Gly Ser Pro Glu Thr Lys 
        835                 840                 845             


Trp Ile Asp Ala Thr Ser Gly Ile Tyr Asn Ser Glu Lys Ser Ser Asn 
    850                 855                 860                 


Leu Ser Val Thr Thr Asp Phe Ser Glu Ser Leu Gln Ser Ser Asn Ile 
865                 870                 875                 880 


Glu Ser Lys Glu Ile Asn Gly Ile His Asp Glu Ser Asn Ala Phe Glu 
                885                 890                 895     


Ser Lys Ala Ser Glu Ser Ile Ser Leu Lys Asn Leu Lys Arg Arg Ser 
            900                 905                 910         


Gln Phe Phe Glu Gln Gly Ser Ser Asp Ser Val Val Pro Asp Leu Pro 
        915                 920                 925             


Val Pro Thr Ile Ser Ala Pro Ser Arg Trp Val Trp Asp Gln Glu Glu 
    930                 935                 940                 


Glu Arg Lys Arg Gln Glu Arg Trp Gln Lys Glu Gln Asp Arg Leu Leu 
945                 950                 955                 960 


Gln Glu Lys Tyr Gln Arg Glu Gln Glu Lys Leu Arg Glu Glu Trp Gln 
                965                 970                 975     


Arg Ala Lys Gln Glu Ala Glu Arg Glu Asn Ser Lys Tyr Leu Asp Glu 
            980                 985                 990         


Glu Leu Met Val Leu Ser Ser Asn  Ser Met Ser Leu Thr  Thr Arg Glu 
        995                 1000                 1005             


Pro Ser  Leu Ala Thr Trp Glu  Ala Thr Trp Ser Glu  Gly Ser Lys 
    1010                 1015                 1020             


Ser Ser  Asp Arg Glu Gly Thr  Arg Ala Gly Glu Glu  Glu Arg Arg 
    1025                 1030                 1035             


Gln Pro  Gln Glu Glu Val Val  His Glu Asp Gln Gly  Lys Lys Pro 
    1040                 1045                 1050             


Gln Asp  Gln Leu Val Ile Glu  Arg Glu Arg Lys Trp  Glu Gln Gln 
    1055                 1060                 1065             


Leu Gln  Glu Glu Gln Glu Gln  Lys Arg Leu Gln Ala  Glu Ala Glu 
    1070                 1075                 1080             


Glu Gln  Lys Arg Pro Ala Glu  Glu Gln Lys Arg Gln  Ala Glu Ile 
    1085                 1090                 1095             


Glu Arg  Glu Thr Ser Val Arg  Ile Tyr Gln Tyr Arg  Arg Pro Val 
    1100                 1105                 1110             


Asp Ser  Tyr Asp Ile Pro Lys  Thr Glu Glu Ala Ser  Ser Gly Phe 
    1115                 1120                 1125             


Leu Pro  Gly Asp Arg Asn Lys  Ser Arg Ser Thr Thr  Glu Leu Asp 
    1130                 1135                 1140             


Asp Tyr  Ser Thr Asn Lys Asn  Gly Asn Asn Lys Tyr  Leu Asp Gln 
    1145                 1150                 1155             


Ile Gly  Asn Met Thr Ser Ser  Gln Arg Arg Ser Lys  Lys Glu Gln 
    1160                 1165                 1170             


Val Pro  Ser Gly Ala Glu Leu  Glu Arg Gln Gln Ile  Leu Gln Glu 
    1175                 1180                 1185             


Met Arg  Lys Arg Thr Pro Leu  His Asn Asp Asn Ser  Trp Ile Arg 
    1190                 1195                 1200             


Gln Arg  Ser Ala Ser Val Asn  Lys Glu Pro Val Ser  Leu Pro Gly 
    1205                 1210                 1215             


Ile Met  Arg Arg Gly Glu Ser  Leu Asp Asn Leu Asp  Ser Pro Arg 
    1220                 1225                 1230             


Ser Asn  Ser Trp Arg Gln Pro  Pro Trp Leu Asn Gln  Pro Thr Gly 
    1235                 1240                 1245             


Phe Tyr  Ala Ser Ser Ser Val  Gln Asp Phe Ser Arg  Pro Pro Pro 
    1250                 1255                 1260             


Gln Leu  Val Ser Thr Ser Asn  Arg Ala Tyr Met Arg  Asn Pro Ser 
    1265                 1270                 1275             


Ser Ser  Val Pro Pro Pro Ser  Ala Gly Ser Val Lys  Thr Ser Thr 
    1280                 1285                 1290             


Thr Gly  Val Ala Thr Thr Gln  Ser Pro Thr Pro Arg  Ser His Ser 
    1295                 1300                 1305             


Pro Ser  Ala Ser Gln Ser Gly  Ser Gln Leu Arg Asn  Ser Val Leu 
    1310                 1315                 1320             


Pro Val  Ser Val Thr Ser Glu  Ala Leu Pro Gln Glu  Leu Lys Ser 
    1325                 1330                 1335             


Gly Ser  Glu Thr Thr Asn Cys  Thr Ala Thr Thr Ala  Ile Ser Asp 
    1340                 1345                 1350             


Ser Asn  Leu Asp Gly Gln Pro  Pro Cys Asp Val Ser  Leu His Thr 
    1355                 1360                 1365             


Lys Ala  Leu Leu Gln Ile Glu  Glu Glu Val Val Ala  Ala His Val 
    1370                 1375                 1380             


Asp Leu  
    1385 


<210> 229
<211> 2558
<212> DNA
<213> Homo sapiens

<400> 229
gtggggcgcg acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca       60

gctgcgggtc cgggattccc agccatggca gattcctccg ggcagcaggg caaaggccgg      120

cgtgtgcagc cccagtggtc ccctcctgct gggacccagc catgcagact ccacctttac      180

aacagcctca ccaggaacaa ggaagtgttc atacctcaag atgggaaaaa ggtgacgtgg      240

tattgctgtg ggccaaccgt ctatgacgca tctcacatgg ggcacgccag gtcctacatc      300

tcttttgata tcttgagaag agtgttgaag gattacttca aatttgatgt cttttattgc      360

atgaacatta cggatattga tgacaagatc atcaagaggg cccggcagaa ccacctgttc      420

gagcagtatc gggagaagag gcctgaagcg gcacagctct tggaggatgt tcaggccgcc      480

ctgaagccat tttcagtaaa attaaatgag accacggatc ccgataaaaa gcagatgctc      540

gaacggattc agcacgcagt gcagcttgcc acagagccac ttgagaaagc tgtgcagtcc      600

agactcacgg gagaggaagt caacagctgt gtggaggtgt tgctggaaga agccaaggat      660

ttgctctctg actggctgga ttctacactt ggctgtgatg tcactgacaa ttccatcttc      720

tccaagctgc ccaagttctg ggagggggac ttccacagag acatggaagc tctgaatgtt      780

ctccctccag atgtcttaac ccgggttagt gagtatgtgc cagaaattgt gaactttgtc      840

cagaagattg tggacaacgg ttacggctat gtctccaatg ggtctgtcta ctttgataca      900

gcgaagtttg cttctagcga gaagcactcc tatgggaagc tggtgcctga ggccgttgga      960

gatcagaaag cccttcaaga aggggaaggt gacctgagca tctctgcaga ccgcctgagt     1020

gagaagcgct ctcccaacga ctttgcctta tggaaggcct ctaagcccgg agaaccgtcc     1080

tggccgtgcc cttggggaaa gggtcgtccg ggctggcata tcgagtgctc ggccatggca     1140

ggcaccctcc taggggcttc gatggacatt cacggaggtg ggttcgacct ccggttcccc     1200

caccatgaca atgagctggc acagtcggag gcctactttg aaaacgactg ctgggtcagg     1260

tacttcctgc acacaggcca cctgaccatt gcaggctgca aaatgtcaaa gtcactaaaa     1320

aacttcatca ccattaaaga tgccttgaaa aagcactcag cacggcagtt gcggctggcc     1380

ttcctcatgc actcgtggaa ggacaccctg gactactcca gcaacaccat ggagtcagcg     1440

cttcaatatg agaagttctt gaatgagttt ttcttaaatg tgaaagatat ccttcgcgct     1500

cctgttgaca tcactggtca gtttgagaag tggggagaag aagaagcaga actgaataag     1560

aacttttatg acaagaagac agcaattcac aaagccctct gtgacaatgt tgacacccgc     1620

accgtcatgg aagagatgcg ggccttggtc agtcagtgca acctctatat ggcagcccgg     1680

aaagccgtga ggaagaggcc caaccaggct ctgctggaga acatcgccct gtacctcacc     1740

catatgctga agatctttgg ggccgtagaa gaggacagct ccctgggatt cccggtcgga     1800

gggcctggaa ccagcctcag tctcgaggcc acagtcatgc cctaccttca ggtgttatca     1860

gaattccgag aaggagtgcg gaagattgcc cgagagcaaa aagtccctga gattctgcag     1920

ctcagcgatg ccctgcggga caacatcctg cccgagcttg gggtgcggtt tgaagaccac     1980

gaaggactgc ccacagtggt gaaactggta gacagaaaca ccttattaaa agagagagaa     2040

gaaaagagac gggttgaaga ggagaagagg aagaagaaag aggaggcggc ccggaggaaa     2100

caggaacaag aagcagcaaa gctggccaag atgaagattc cccccagtga gatgttcttg     2160

tcagaaaccg acaaatactc caagtttgat gaaaatgtaa gcatggtctg cccacacatg     2220

acatggaggg caaagagctc agcaaagggc aagccaagaa gctgaagaag ctcttcgagg     2280

ctcaggagaa gctctacaag gaatatctgc agatggccca gaatggaagc ttccagtgag     2340

ggggcacagg actgactttt taaaccattg tggactagtg gctgctgtct gcctcagtga     2400

caatgtccca gcgctcctat catgtttaca gtcacccttg ggtcctaaat taagagttgt     2460

gttcatgtag gttcgtgtcg tcgttggctc tgagacattg ataataaatt tttctcaaca     2520

gtgagaccct caaaaaaaaa aaaaaaaaaa aaaaaaaa                             2558


<210> 230
<211> 726
<212> PRT
<213> Homo sapiens

<400> 230
Met Ala Asp Ser Ser Gly Gln Gln Gly Lys Gly Arg Arg Val Gln Pro 
1               5                   10                  15      


Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu His Leu Tyr 
            20                  25                  30          


Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln Asp Gly Lys 
        35                  40                  45              


Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp Ala Ser His 
    50                  55                  60                  


Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu Arg Arg Val 
65                  70                  75                  80  


Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met Asn Ile Thr 
                85                  90                  95      


Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu Phe 
            100                 105                 110         


Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu Asp 
        115                 120                 125             


Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr Thr 
    130                 135                 140                 


Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln 
145                 150                 155                 160 


Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly 
                165                 170                 175     


Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp 
            180                 185                 190         


Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp 
        195                 200                 205             


Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His 
    210                 215                 220                 


Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg 
225                 230                 235                 240 


Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val 
                245                 250                 255     


Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr Phe Asp Thr 
            260                 265                 270         


Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro 
        275                 280                 285             


Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu 
    290                 295                 300                 


Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe 
305                 310                 315                 320 


Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro 
                325                 330                 335     


Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala 
            340                 345                 350         


Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp 
        355                 360                 365             


Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr 
    370                 375                 380                 


Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu 
385                 390                 395                 400 


Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr 
                405                 410                 415     


Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala 
            420                 425                 430         


Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr 
        435                 440                 445             


Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu 
    450                 455                 460                 


Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe 
465                 470                 475                 480 


Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp 
                485                 490                 495     


Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg 
            500                 505                 510         


Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr 
        515                 520                 525             


Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu 
    530                 535                 540                 


Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala 
545                 550                 555                 560 


Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr 
                565                 570                 575     


Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser 
            580                 585                 590         


Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro 
        595                 600                 605             


Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu 
    610                 615                 620                 


Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys 
625                 630                 635                 640 


Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg 
                645                 650                 655     


Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys 
            660                 665                 670         


Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser 
        675                 680                 685             


Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn 
    690                 695                 700                 


Val Ser Met Val Cys Pro His Met Thr Trp Arg Ala Lys Ser Ser Ala 
705                 710                 715                 720 


Lys Gly Lys Pro Arg Ser 
                725     


<210> 231
<211> 2550
<212> DNA
<213> Homo sapiens

<400> 231
gtggggcgcg acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca       60

gctgcgggtc cgggattccc agccatggca gattcctccg ggcagcaggg caaaggccgg      120

cgtgtgcagc cccagtggtc ccctcctgct gggacccagc catgcagact ccacctttac      180

aacagcctca ccaggaacaa ggaagtgttc atacctcaag atgggaaaaa ggtgacgtgg      240

tattgctgtg ggccaaccgt ctatgacgca tctcacatgg ggcacgccag gtcctacatc      300

tcttttgata tcttgagaag agtgttgaag gattacttca aatttgatgt cttttattgc      360

atgaacatta cggatattga tgacaagatc atcaagaggg cccggcagaa ccacctgttc      420

gagcagtatc gggagaagag gcctgaagcg gcacagctct tggaggatgt tcaggccgcc      480

ctgaagccat tttcagtaaa attaaatgag accacggatc ccgataaaaa gcagatgctc      540

gaacggattc agcacgcagt gcagcttgcc acagagccac ttgagaaagc tgtgcagtcc      600

agactcacgg gagaggaagt caacagctgt gtggaggtgt tgctggaaga agccaaggat      660

ttgctctctg actggctgga ttctacactt ggctgtgatg tcactgacaa ttccatcttc      720

tccaagctgc ccaagttctg ggagggggac ttccacagag acatggaagc tctgaatgtt      780

ctccctccag atgtcttaac ccgggttagt gagtatgtgc cagaaattgt gaactttgtc      840

cagaagattg tggacaacgg ttacggctat gtctccaatg ggtctgtcta ctttgataca      900

gcgaagtttg cttctagcga gaagcactcc tatgggaagc tggtgcctga ggccgttgga      960

gatcagaaag cccttcaaga aggggaaggt gacctgagca tctctgcaga ccgcctgagt     1020

gagaagcgct ctcccaacga ctttgcctta tggaaggcct ctaagcccgg agaaccgtcc     1080

tggccgtgcc cttggggaaa gggtcgtccg ggctggcata tcgagtgctc ggccatggca     1140

ggcaccctcc taggggcttc gatggacatt cacggaggtg ggttcgacct ccggttcccc     1200

caccatgaca atgagctggc acagtcggag gcctactttg aaaacgactg ctgggtcagg     1260

tacttcctgc acacaggcca cctgaccatt gcaggctgca aaatgtcaaa gtcactaaaa     1320

aacttcatca ccattaaaga tgccttgaaa aagcactcag cacggcagtt gcggctggcc     1380

ttcctcatgc actcgtggaa ggacaccctg gactactcca gcaacaccat ggagtcagcg     1440

cttcaatatg agaagttctt gaatgagttt ttcttaaatg tgaaagatat ccttcgcgct     1500

cctgttgaca tcactggtca gtttgagaag tggggagaag aagaagcaga actgaataag     1560

aacttttatg acaagaagac agcaattcac aaagccctct gtgacaatgt tgacacccgc     1620

accgtcatgg aagagatgcg ggccttggtc agtcagtgca acctctatat ggcagcccgg     1680

aaagccgtga ggaagaggcc caaccaggct ctgctggaga acatcgccct gtacctcacc     1740

catatgctga agatctttgg ggccgtagaa gaggacagct ccctgggatt cccggtcgga     1800

gggcctggaa ccagcctcag tctcgaggcc acagtcatgc cctaccttca ggtgttatca     1860

gaattccgag aaggagtgcg gaagattgcc cgagagcaaa aagtccctga gattctgcag     1920

ctcagcgatg ccctgcggga caacatcctg cccgagcttg gggtgcggtt tgaagaccac     1980

gaaggactgc ccacagtggt gaaactggta gacagaaaca ccttattaaa agagagagaa     2040

gaaaagagac gggttgaaga ggagaagagg aagaagaaag aggaggcggc ccggaggaaa     2100

caggaacaag aagcagcaaa gctggccaag atgaagattc cccccagtga gatgttcttg     2160

tcagaaaccg acaaatactc caagtttgat gaaaatggtc tgcccacaca tgacatggag     2220

ggcaaagagc tcagcaaagg gcaagccaag aagctgaaga agctcttcga ggctcaggag     2280

aagctctaca aggaatatct gcagatggcc cagaatggaa gcttccagtg agggggcaca     2340

ggactgactt tttaaaccat tgtggactag tggctgctgt ctgcctcagt gacaatgtcc     2400

cagcgctcct atcatgttta cagtcaccct tgggtcctaa attaagagtt gtgttcatgt     2460

aggttcgtgt cgtcgttggc tctgagacat tgataataaa tttttctcaa cagtgagacc     2520

ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      2550


<210> 232
<211> 748
<212> PRT
<213> Homo sapiens

<400> 232
Met Ala Asp Ser Ser Gly Gln Gln Gly Lys Gly Arg Arg Val Gln Pro 
1               5                   10                  15      


Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu His Leu Tyr 
            20                  25                  30          


Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln Asp Gly Lys 
        35                  40                  45              


Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp Ala Ser His 
    50                  55                  60                  


Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu Arg Arg Val 
65                  70                  75                  80  


Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met Asn Ile Thr 
                85                  90                  95      


Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu Phe 
            100                 105                 110         


Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu Asp 
        115                 120                 125             


Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr Thr 
    130                 135                 140                 


Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln 
145                 150                 155                 160 


Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly 
                165                 170                 175     


Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp 
            180                 185                 190         


Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp 
        195                 200                 205             


Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His 
    210                 215                 220                 


Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg 
225                 230                 235                 240 


Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val 
                245                 250                 255     


Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr Phe Asp Thr 
            260                 265                 270         


Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro 
        275                 280                 285             


Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu 
    290                 295                 300                 


Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe 
305                 310                 315                 320 


Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro 
                325                 330                 335     


Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala 
            340                 345                 350         


Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp 
        355                 360                 365             


Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr 
    370                 375                 380                 


Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu 
385                 390                 395                 400 


Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr 
                405                 410                 415     


Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala 
            420                 425                 430         


Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr 
        435                 440                 445             


Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu 
    450                 455                 460                 


Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe 
465                 470                 475                 480 


Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp 
                485                 490                 495     


Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg 
            500                 505                 510         


Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr 
        515                 520                 525             


Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu 
    530                 535                 540                 


Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala 
545                 550                 555                 560 


Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr 
                565                 570                 575     


Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser 
            580                 585                 590         


Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro 
        595                 600                 605             


Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu 
    610                 615                 620                 


Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys 
625                 630                 635                 640 


Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg 
                645                 650                 655     


Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys 
            660                 665                 670         


Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser 
        675                 680                 685             


Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn 
    690                 695                 700                 


Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser Lys Gly Gln 
705                 710                 715                 720 


Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys Leu Tyr Lys 
                725                 730                 735     


Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln 
            740                 745             


<210> 233
<211> 2799
<212> DNA
<213> Homo sapiens

<400> 233
gtggggcgcg acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca       60

gctgcgggtc cgggattccc agccatggca gattcctccg ggcagcaggc tcctgactac      120

aggtccattc tgagcattag tgacgaggca gccagggcac aagccctgaa cgagcacctc      180

agcacgcgta gctatgtcca ggggtactca ctgtcccagg cagacgtgga cgcgttcagg      240

cagctctcgg ccccgcccgc tgacccccag ctcttccacg tggctcggtg gttcaggcac      300

atagaagcgc tcctgggtag cccctgtggc aaaggccagc cctgcaggct ccaagcaagc      360

aaaggccggc gtgtgcagcc ccagtggtcc cctcctgctg ggacccagcc atgcagactc      420

cacctttaca acagcctcac caggaacaag gaagtgttca tacctcaaga tgggaaaaag      480

gtgacgtggt attgctgtgg gccaaccgtc tatgacgcat ctcacatggg gcacgccagg      540

tcctacatct cttttgatat cttgagaaga gtgttgaagg attacttcaa atttgatgtc      600

ttttattgca tgaacattac ggatattgat gacaagatca tcaagagggc ccggcagaac      660

cacctgttcg agcagtatcg ggagaagagg cctgaagcgg cacagctctt ggaggatgtt      720

caggccgccc tgaagccatt ttcagtaaaa ttaaatgaga ccacggatcc cgataaaaag      780

cagatgctcg aacggattca gcacgcagtg cagcttgcca cagagccact tgagaaagct      840

gtgcagtcca gactcacggg agaggaagtc aacagctgtg tggaggtgtt gctggaagaa      900

gccaaggatt tgctctctga ctggctggat tctacacttg gctgtgatgt cactgacaat      960

tccatcttct ccaagctgcc caagttctgg gagggggact tccacagaga catggaagct     1020

ctgaatgttc tccctccaga tgtcttaacc cgggttagtg agtatgtgcc agaaattgtg     1080

aactttgtcc agaagattgt ggacaacggt tacggctatg tctccaatgg gtctgtctac     1140

tttgatacag cgaagtttgc ttctagcgag aagcactcct atgggaagct ggtgcctgag     1200

gccgttggag atcagaaagc ccttcaagaa ggggaaggtg acctgagcat ctctgcagac     1260

cgcctgagtg agaagcgctc tcccaacgac tttgccttat ggaaggcctc taagcccgga     1320

gaaccgtcct ggccgtgccc ttggggaaag ggtcgtccgg gctggcatat cgagtgctcg     1380

gccatggcag gcaccctcct aggggcttcg atggacattc acggaggtgg gttcgacctc     1440

cggttccccc accatgacaa tgagctggca cagtcggagg cctactttga aaacgactgc     1500

tgggtcaggt acttcctgca cacaggccac ctgaccattg caggctgcaa aatgtcaaag     1560

tcactaaaaa acttcatcac cattaaagat gccttgaaaa agcactcagc acggcagttg     1620

cggctggcct tcctcatgca ctcgtggaag gacaccctgg actactccag caacaccatg     1680

gagtcagcgc ttcaatatga gaagttcttg aatgagtttt tcttaaatgt gaaagatatc     1740

cttcgcgctc ctgttgacat cactggtcag tttgagaagt ggggagaaga agaagcagaa     1800

ctgaataaga acttttatga caagaagaca gcaattcaca aagccctctg tgacaatgtt     1860

gacacccgca ccgtcatgga agagatgcgg gccttggtca gtcagtgcaa cctctatatg     1920

gcagcccgga aagccgtgag gaagaggccc aaccaggctc tgctggagaa catcgccctg     1980

tacctcaccc atatgctgaa gatctttggg gccgtagaag aggacagctc cctgggattc     2040

ccggtcggag ggcctggaac cagcctcagt ctcgaggcca cagtcatgcc ctaccttcag     2100

gtgttatcag aattccgaga aggagtgcgg aagattgccc gagagcaaaa agtccctgag     2160

attctgcagc tcagcgatgc cctgcgggac aacatcctgc ccgagcttgg ggtgcggttt     2220

gaagaccacg aaggactgcc cacagtggtg aaactggtag acagaaacac cttattaaaa     2280

gagagagaag aaaagagacg ggttgaagag gagaagagga agaagaaaga ggaggcggcc     2340

cggaggaaac aggaacaaga agcagcaaag ctggccaaga tgaagattcc ccccagtgag     2400

atgttcttgt cagaaaccga caaatactcc aagtttgatg aaaatggtct gcccacacat     2460

gacatggagg gcaaagagct cagcaaaggg caagccaaga agctgaagaa gctcttcgag     2520

gctcaggaga agctctacaa ggaatatctg cagatggccc agaatggaag cttccagtga     2580

gggggcacag gactgacttt ttaaaccatt gtggactagt ggctgctgtc tgcctcagtg     2640

acaatgtccc agcgctccta tcatgtttac agtcaccctt gggtcctaaa ttaagagttg     2700

tgttcatgta ggttcgtgtc gtcgttggct ctgagacatt gataataaat ttttctcaac     2760

agtgagaccc tcaaaaaaaa aaaaaaaaaa aaaaaaaaa                            2799


<210> 234
<211> 831
<212> PRT
<213> Homo sapiens

<400> 234
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu 
1               5                   10                  15      


Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu 
            20                  25                  30          


Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val 
        35                  40                  45              


Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe 
    50                  55                  60                  


His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro 
65                  70                  75                  80  


Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg 
                85                  90                  95      


Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu 
            100                 105                 110         


His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln 
        115                 120                 125             


Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp 
    130                 135                 140                 


Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu 
145                 150                 155                 160 


Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met 
                165                 170                 175     


Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn 
            180                 185                 190         


His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu 
        195                 200                 205             


Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn 
    210                 215                 220                 


Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His 
225                 230                 235                 240 


Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg 
                245                 250                 255     


Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu 
            260                 265                 270         


Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp 
        275                 280                 285             


Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly 
    290                 295                 300                 


Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val 
305                 310                 315                 320 


Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln 
                325                 330                 335     


Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr 
            340                 345                 350         


Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys 
        355                 360                 365             


Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu 
    370                 375                 380                 


Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro 
385                 390                 395                 400 


Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp 
                405                 410                 415     


Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser 
            420                 425                 430         


Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly 
        435                 440                 445             


Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser 
    450                 455                 460                 


Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr 
465                 470                 475                 480 


Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn 
                485                 490                 495     


Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu 
            500                 505                 510         


Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser 
        515                 520                 525             


Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu 
    530                 535                 540                 


Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr 
545                 550                 555                 560 


Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn 
                565                 570                 575     


Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val 
            580                 585                 590         


Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys 
        595                 600                 605             


Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln 
    610                 615                 620                 


Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile 
625                 630                 635                 640 


Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly 
                645                 650                 655     


Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln 
            660                 665                 670         


Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln 
        675                 680                 685             


Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile 
    690                 695                 700                 


Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr 
705                 710                 715                 720 


Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu 
                725                 730                 735     


Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala 
            740                 745                 750         


Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile 
        755                 760                 765             


Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe 
    770                 775                 780                 


Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser 
785                 790                 795                 800 


Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys 
                805                 810                 815     


Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln 
            820                 825                 830     


<210> 235
<211> 2807
<212> DNA
<213> Homo sapiens

<400> 235
gtggggcgcg acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca       60

gctgcgggtc cgggattccc agccatggca gattcctccg ggcagcaggc tcctgactac      120

aggtccattc tgagcattag tgacgaggca gccagggcac aagccctgaa cgagcacctc      180

agcacgcgta gctatgtcca ggggtactca ctgtcccagg cagacgtgga cgcgttcagg      240

cagctctcgg ccccgcccgc tgacccccag ctcttccacg tggctcggtg gttcaggcac      300

atagaagcgc tcctgggtag cccctgtggc aaaggccagc cctgcaggct ccaagcaagc      360

aaaggccggc gtgtgcagcc ccagtggtcc cctcctgctg ggacccagcc atgcagactc      420

cacctttaca acagcctcac caggaacaag gaagtgttca tacctcaaga tgggaaaaag      480

gtgacgtggt attgctgtgg gccaaccgtc tatgacgcat ctcacatggg gcacgccagg      540

tcctacatct cttttgatat cttgagaaga gtgttgaagg attacttcaa atttgatgtc      600

ttttattgca tgaacattac ggatattgat gacaagatca tcaagagggc ccggcagaac      660

cacctgttcg agcagtatcg ggagaagagg cctgaagcgg cacagctctt ggaggatgtt      720

caggccgccc tgaagccatt ttcagtaaaa ttaaatgaga ccacggatcc cgataaaaag      780

cagatgctcg aacggattca gcacgcagtg cagcttgcca cagagccact tgagaaagct      840

gtgcagtcca gactcacggg agaggaagtc aacagctgtg tggaggtgtt gctggaagaa      900

gccaaggatt tgctctctga ctggctggat tctacacttg gctgtgatgt cactgacaat      960

tccatcttct ccaagctgcc caagttctgg gagggggact tccacagaga catggaagct     1020

ctgaatgttc tccctccaga tgtcttaacc cgggttagtg agtatgtgcc agaaattgtg     1080

aactttgtcc agaagattgt ggacaacggt tacggctatg tctccaatgg gtctgtctac     1140

tttgatacag cgaagtttgc ttctagcgag aagcactcct atgggaagct ggtgcctgag     1200

gccgttggag atcagaaagc ccttcaagaa ggggaaggtg acctgagcat ctctgcagac     1260

cgcctgagtg agaagcgctc tcccaacgac tttgccttat ggaaggcctc taagcccgga     1320

gaaccgtcct ggccgtgccc ttggggaaag ggtcgtccgg gctggcatat cgagtgctcg     1380

gccatggcag gcaccctcct aggggcttcg atggacattc acggaggtgg gttcgacctc     1440

cggttccccc accatgacaa tgagctggca cagtcggagg cctactttga aaacgactgc     1500

tgggtcaggt acttcctgca cacaggccac ctgaccattg caggctgcaa aatgtcaaag     1560

tcactaaaaa acttcatcac cattaaagat gccttgaaaa agcactcagc acggcagttg     1620

cggctggcct tcctcatgca ctcgtggaag gacaccctgg actactccag caacaccatg     1680

gagtcagcgc ttcaatatga gaagttcttg aatgagtttt tcttaaatgt gaaagatatc     1740

cttcgcgctc ctgttgacat cactggtcag tttgagaagt ggggagaaga agaagcagaa     1800

ctgaataaga acttttatga caagaagaca gcaattcaca aagccctctg tgacaatgtt     1860

gacacccgca ccgtcatgga agagatgcgg gccttggtca gtcagtgcaa cctctatatg     1920

gcagcccgga aagccgtgag gaagaggccc aaccaggctc tgctggagaa catcgccctg     1980

tacctcaccc atatgctgaa gatctttggg gccgtagaag aggacagctc cctgggattc     2040

ccggtcggag ggcctggaac cagcctcagt ctcgaggcca cagtcatgcc ctaccttcag     2100

gtgttatcag aattccgaga aggagtgcgg aagattgccc gagagcaaaa agtccctgag     2160

attctgcagc tcagcgatgc cctgcgggac aacatcctgc ccgagcttgg ggtgcggttt     2220

gaagaccacg aaggactgcc cacagtggtg aaactggtag acagaaacac cttattaaaa     2280

gagagagaag aaaagagacg ggttgaagag gagaagagga agaagaaaga ggaggcggcc     2340

cggaggaaac aggaacaaga agcagcaaag ctggccaaga tgaagattcc ccccagtgag     2400

atgttcttgt cagaaaccga caaatactcc aagtttgatg aaaatgtaag catggtctgc     2460

ccacacatga catggagggc aaagagctca gcaaagggca agccaagaag ctgaagaagc     2520

tcttcgaggc tcaggagaag ctctacaagg aatatctgca gatggcccag aatggaagct     2580

tccagtgagg gggcacagga ctgacttttt aaaccattgt ggactagtgg ctgctgtctg     2640

cctcagtgac aatgtcccag cgctcctatc atgtttacag tcacccttgg gtcctaaatt     2700

aagagttgtg ttcatgtagg ttcgtgtcgt cgttggctct gagacattga taataaattt     2760

ttctcaacag tgagaccctc aaaaaaaaaa aaaaaaaaaa aaaaaaa                   2807


<210> 236
<211> 809
<212> PRT
<213> Homo sapiens

<400> 236
Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu 
1               5                   10                  15      


Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu 
            20                  25                  30          


Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val 
        35                  40                  45              


Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe 
    50                  55                  60                  


His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro 
65                  70                  75                  80  


Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg 
                85                  90                  95      


Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu 
            100                 105                 110         


His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln 
        115                 120                 125             


Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp 
    130                 135                 140                 


Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu 
145                 150                 155                 160 


Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met 
                165                 170                 175     


Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn 
            180                 185                 190         


His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu 
        195                 200                 205             


Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn 
    210                 215                 220                 


Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His 
225                 230                 235                 240 


Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg 
                245                 250                 255     


Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu 
            260                 265                 270         


Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp 
        275                 280                 285             


Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly 
    290                 295                 300                 


Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val 
305                 310                 315                 320 


Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln 
                325                 330                 335     


Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr 
            340                 345                 350         


Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys 
        355                 360                 365             


Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu 
    370                 375                 380                 


Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro 
385                 390                 395                 400 


Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp 
                405                 410                 415     


Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser 
            420                 425                 430         


Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly 
        435                 440                 445             


Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser 
    450                 455                 460                 


Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr 
465                 470                 475                 480 


Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn 
                485                 490                 495     


Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu 
            500                 505                 510         


Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser 
        515                 520                 525             


Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu 
    530                 535                 540                 


Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr 
545                 550                 555                 560 


Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn 
                565                 570                 575     


Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val 
            580                 585                 590         


Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys 
        595                 600                 605             


Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln 
    610                 615                 620                 


Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile 
625                 630                 635                 640 


Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly 
                645                 650                 655     


Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln 
            660                 665                 670         


Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln 
        675                 680                 685             


Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile 
    690                 695                 700                 


Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr 
705                 710                 715                 720 


Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu 
                725                 730                 735     


Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala 
            740                 745                 750         


Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile 
        755                 760                 765             


Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe 
    770                 775                 780                 


Asp Glu Asn Val Ser Met Val Cys Pro His Met Thr Trp Arg Ala Lys 
785                 790                 795                 800 


Ser Ser Ala Lys Gly Lys Pro Arg Ser 
                805                 


<210> 237
<211> 2755
<212> DNA
<213> Homo sapiens

<400> 237
ctaatcacca aacatctgct tccttctctg tagctgtgac cctgataccg cgtggtgtgc       60

tccgaacaca tggtgcccag aacgaaggcg gcgtccagaa gccctaggtc ccagaggtcc      120

gctcagcggc aggcgcataa ggcggggccg gcgcgggcct ttccttccat cggaaccgtt      180

ctcccggggc tgagtccctg cccggactcc gaacgccgaa gaccaggggc cggaagcgcg      240

cgccgccact gccacgccgt gtcagtcggg agggagggag cgagcaggcg aagccgcgga      300

ggacggggtg aagatggcgg ccttctccga gatgggtgta atgcctgaga ttgcacaagc      360

tgtggaagag atggattggc tcctcccaac tgatatccag gctgaatcta tcccattgat      420

cttaggagga ggtgatgtac ttatggctgc agaaacagga agtggcaaaa ctggtgcttt      480

tagtattcca gttatccaga tagtttatga aactctgaaa gaccaacagg aaggcaaaaa      540

aggaaaaaca acaattaaaa ctggtgcttc agtgctgaac aaatggcaga tgaacccata      600

tgacagagga tctgcttttg caattgggtc agatggtctt tgttgtcaaa gcagagaagt      660

aaaggaatgg catgggtgta gagctactaa aggattaatg aaagggaaac actactatga      720

agtatcctgt catgaccaag ggttatgcag ggtcgggtgg tctaccatgc aggcctcttt      780

ggacctaggt actgacaagt ttggatttgg ctttggtgga acaggaaaga aatcccataa      840

caaacaattt gataattatg gagaggaatt cactatgcat gataccattg gatgttacct      900

ggatatagat aagggacatg tcaagttctc caaaaatgga aaagatcttg gtctggcatt      960

tgaaatacca ccacatatga aaaaccaagc cctctttcct gcctgtgttt tgaagaatgc     1020

tgaactgaaa tttaacttcg gtgaagagga atttaagttt ccaccaaaag atggctttgt     1080

tgctctttcc aaggcaccgg atggttacat tgtcaaatca cagcactcag gtaatgcaca     1140

ggtgacacaa acaaagtttc tccccaatgc tccgaaagct ctcattgttg aaccttcccg     1200

ggagttagct gaacaaactt tgaacaacat caagcagttt aagaaataca ttgataatcc     1260

taaattaagg gagcttctga taattggagg tgttgcagcc cgggatcagc tctctgtttt     1320

ggaaaatgga gtagatatag ttgtaggtac tccgggaaga ctagatgact tggtgtcaac     1380

tggaaagctg aacttatctc aagttagatt cctggtcctg gatgaagctg atgggcttct     1440

ttctcaaggt tattctgatt ttataaatag gatgcacaat cagattcctc aggttacctc     1500

tgatggaaaa agacttcagg tgattgtttg ctctgccact ttgcattctt tcgatgtaaa     1560

gaaactgtcc gagaagataa tgcattttcc tacatgggtt gacttaaaag gagaagactc     1620

tgttccagat actgtacacc atgttgttgt cccagtaaat cccaaaactg acagactctg     1680

ggaaaggctt ggaaagagcc acattagaac tgatgatgta catgcaaaag ataacacaag     1740

acctggtgct aatagtccag agatgtggtc tgaagctatt aaaatcctga aaggggagta     1800

tgctgtccgg gcaatcaagg aacataagat ggatcaagca attatcttct gtagaaccaa     1860

aattgactgt gataacttgg agcagtactt tatacaacaa ggaggaggac ctgataaaaa     1920

aggacaccag ttctcatgtg tttgtcttca tggtgacaga aagcctcatg agagaaagca     1980

aaacttggaa agatttaaga aaggagatgt aagattcttg atttgcacag atgtagctgc     2040

tagaggaatt gatatccacg gtgttcctta tgttataaat gtcactctgc ccgatgaaaa     2100

gcaaaactac gtacatcgaa ttggcagagt aggaagagct gaaaggatgg gtctggcaat     2160

ttccctggtg gcaacagaaa aagaaaaggt ttggtaccat gtatgtagca gccgtggaaa     2220

agggtgttat aacacaagac tcaaggaaga tggaggctgt accatatggt acaacgagat     2280

gcagttacta tctgagatag aagaacacct gaactgtacc atttctcagg ttgagccgga     2340

tataaaggta ccagtggatg aatttgatgg gaaagttacc tacggtcaga aaagggctgc     2400

tggtggtgga agctataaag gccatgtgga tattttggca cctactgttc aagagttggc     2460

tgcccttgaa aaggaggcgc agacatcttt cctgcatctt ggctaccttc ctaaccagct     2520

gttcagaacc ttctgatttt tacatttact gaataagatt tgagtaatga aagtctgtag     2580

tcttaaaact ctaaaacagt tgtactgctt ccaagcagca gtatttatag taacgtaagc     2640

tattaatgct aactcttgca tgtcaagaaa cattagtctt aggaattctt caaaaaatgg     2700

catcccaatg aaaataaatt tgatgactat attttcatga aaaaaaaaaa aaaaa          2755


<210> 238
<211> 740
<212> PRT
<213> Homo sapiens

<400> 238
Met Ala Ala Phe Ser Glu Met Gly Val Met Pro Glu Ile Ala Gln Ala 
1               5                   10                  15      


Val Glu Glu Met Asp Trp Leu Leu Pro Thr Asp Ile Gln Ala Glu Ser 
            20                  25                  30          


Ile Pro Leu Ile Leu Gly Gly Gly Asp Val Leu Met Ala Ala Glu Thr 
        35                  40                  45              


Gly Ser Gly Lys Thr Gly Ala Phe Ser Ile Pro Val Ile Gln Ile Val 
    50                  55                  60                  


Tyr Glu Thr Leu Lys Asp Gln Gln Glu Gly Lys Lys Gly Lys Thr Thr 
65                  70                  75                  80  


Ile Lys Thr Gly Ala Ser Val Leu Asn Lys Trp Gln Met Asn Pro Tyr 
                85                  90                  95      


Asp Arg Gly Ser Ala Phe Ala Ile Gly Ser Asp Gly Leu Cys Cys Gln 
            100                 105                 110         


Ser Arg Glu Val Lys Glu Trp His Gly Cys Arg Ala Thr Lys Gly Leu 
        115                 120                 125             


Met Lys Gly Lys His Tyr Tyr Glu Val Ser Cys His Asp Gln Gly Leu 
    130                 135                 140                 


Cys Arg Val Gly Trp Ser Thr Met Gln Ala Ser Leu Asp Leu Gly Thr 
145                 150                 155                 160 


Asp Lys Phe Gly Phe Gly Phe Gly Gly Thr Gly Lys Lys Ser His Asn 
                165                 170                 175     


Lys Gln Phe Asp Asn Tyr Gly Glu Glu Phe Thr Met His Asp Thr Ile 
            180                 185                 190         


Gly Cys Tyr Leu Asp Ile Asp Lys Gly His Val Lys Phe Ser Lys Asn 
        195                 200                 205             


Gly Lys Asp Leu Gly Leu Ala Phe Glu Ile Pro Pro His Met Lys Asn 
    210                 215                 220                 


Gln Ala Leu Phe Pro Ala Cys Val Leu Lys Asn Ala Glu Leu Lys Phe 
225                 230                 235                 240 


Asn Phe Gly Glu Glu Glu Phe Lys Phe Pro Pro Lys Asp Gly Phe Val 
                245                 250                 255     


Ala Leu Ser Lys Ala Pro Asp Gly Tyr Ile Val Lys Ser Gln His Ser 
            260                 265                 270         


Gly Asn Ala Gln Val Thr Gln Thr Lys Phe Leu Pro Asn Ala Pro Lys 
        275                 280                 285             


Ala Leu Ile Val Glu Pro Ser Arg Glu Leu Ala Glu Gln Thr Leu Asn 
    290                 295                 300                 


Asn Ile Lys Gln Phe Lys Lys Tyr Ile Asp Asn Pro Lys Leu Arg Glu 
305                 310                 315                 320 


Leu Leu Ile Ile Gly Gly Val Ala Ala Arg Asp Gln Leu Ser Val Leu 
                325                 330                 335     


Glu Asn Gly Val Asp Ile Val Val Gly Thr Pro Gly Arg Leu Asp Asp 
            340                 345                 350         


Leu Val Ser Thr Gly Lys Leu Asn Leu Ser Gln Val Arg Phe Leu Val 
        355                 360                 365             


Leu Asp Glu Ala Asp Gly Leu Leu Ser Gln Gly Tyr Ser Asp Phe Ile 
    370                 375                 380                 


Asn Arg Met His Asn Gln Ile Pro Gln Val Thr Ser Asp Gly Lys Arg 
385                 390                 395                 400 


Leu Gln Val Ile Val Cys Ser Ala Thr Leu His Ser Phe Asp Val Lys 
                405                 410                 415     


Lys Leu Ser Glu Lys Ile Met His Phe Pro Thr Trp Val Asp Leu Lys 
            420                 425                 430         


Gly Glu Asp Ser Val Pro Asp Thr Val His His Val Val Val Pro Val 
        435                 440                 445             


Asn Pro Lys Thr Asp Arg Leu Trp Glu Arg Leu Gly Lys Ser His Ile 
    450                 455                 460                 


Arg Thr Asp Asp Val His Ala Lys Asp Asn Thr Arg Pro Gly Ala Asn 
465                 470                 475                 480 


Ser Pro Glu Met Trp Ser Glu Ala Ile Lys Ile Leu Lys Gly Glu Tyr 
                485                 490                 495     


Ala Val Arg Ala Ile Lys Glu His Lys Met Asp Gln Ala Ile Ile Phe 
            500                 505                 510         


Cys Arg Thr Lys Ile Asp Cys Asp Asn Leu Glu Gln Tyr Phe Ile Gln 
        515                 520                 525             


Gln Gly Gly Gly Pro Asp Lys Lys Gly His Gln Phe Ser Cys Val Cys 
    530                 535                 540                 


Leu His Gly Asp Arg Lys Pro His Glu Arg Lys Gln Asn Leu Glu Arg 
545                 550                 555                 560 


Phe Lys Lys Gly Asp Val Arg Phe Leu Ile Cys Thr Asp Val Ala Ala 
                565                 570                 575     


Arg Gly Ile Asp Ile His Gly Val Pro Tyr Val Ile Asn Val Thr Leu 
            580                 585                 590         


Pro Asp Glu Lys Gln Asn Tyr Val His Arg Ile Gly Arg Val Gly Arg 
        595                 600                 605             


Ala Glu Arg Met Gly Leu Ala Ile Ser Leu Val Ala Thr Glu Lys Glu 
    610                 615                 620                 


Lys Val Trp Tyr His Val Cys Ser Ser Arg Gly Lys Gly Cys Tyr Asn 
625                 630                 635                 640 


Thr Arg Leu Lys Glu Asp Gly Gly Cys Thr Ile Trp Tyr Asn Glu Met 
                645                 650                 655     


Gln Leu Leu Ser Glu Ile Glu Glu His Leu Asn Cys Thr Ile Ser Gln 
            660                 665                 670         


Val Glu Pro Asp Ile Lys Val Pro Val Asp Glu Phe Asp Gly Lys Val 
        675                 680                 685             


Thr Tyr Gly Gln Lys Arg Ala Ala Gly Gly Gly Ser Tyr Lys Gly His 
    690                 695                 700                 


Val Asp Ile Leu Ala Pro Thr Val Gln Glu Leu Ala Ala Leu Glu Lys 
705                 710                 715                 720 


Glu Ala Gln Thr Ser Phe Leu His Leu Gly Tyr Leu Pro Asn Gln Leu 
                725                 730                 735     


Phe Arg Thr Phe 
            740 


<210> 239
<211> 2333
<212> DNA
<213> Homo sapiens

<400> 239
ctcacatccg gcatgcgccg tgctcgctca cagaactaca ctttccaact ctccccacac       60

gacccgtgac actctgtgga ccgcgagcac ggagcagggt ttctacagct gctccccact      120

ttctcggacc cggtcctgga cccagccccc gactccgaca cggctccacc atggaggagg      180

cggaccgaat cctcatccat tcgctgcgcc aggccggcac ggcagttcct ccagatgtgc      240

agaccttgcg cgccttcacc actgagctgg ttgtagaggc tgtggtccgc tgcctgcgtg      300

tgatcaaccc tgcggtgggc tctggcctca gccctctgct gcctcttgcc atgtctgccc      360

ggttccgcct ggccatgagc ctggctcagg cctgcatgga cctgggctat cccttggagc      420

ttggctatca gaacttcctc taccccagtg agcctgacct ccgagacctg cttctcttct      480

tggctgagcg tctgcccacc gatgcctctg aggatgcaga ccagcctgca ggtgactcag      540

ctattctcct ccgggccatt gggagccaaa ttcgggacca gctggcactg ccttgggtcc      600

cgccccacct tcgcactccc aagctgcagc acctccaggg ctcggccctc cagaagcctt      660

tccatgccag caggctggtc gtgccagaat tgagttccag aggtgagcca cgggagttcc      720

aggcgagtcc cctgctgctt ccagtcccta cccaggtgcc tcagcctgtt ggaagggtgg      780

cctcgctcct cgaacaccat gccctgcagc tctgccagca gacgggccgg gaccggccag      840

gggatgagga ctgggtccac cggacatccc gcctcccacc ccaggaggac acacgggctc      900

agcggcagcg gctgcagaag caactgactg agcatctgcg ccaaagctgg ggcctgcttg      960

gggcccccat acaagcccgg gacctgggag aactgctgca ggcctggggt gctggggcca     1020

agactggtgc tcctaagggc tcccgcttca cgcactcaga gaagttcacc ttccatctgg     1080

agccccaggc ccaggccact caggtgtcag atgtgccagc cacctcccgg cggcctgaac     1140

aggtcacgtg ggcagctcag gaacaggagc tcgagtccct tcgggagcag ctggaaggag     1200

tgaaccgcag cattgaggag gttgaggccg acatgaagac cctgggcgtc agctttgtgc     1260

aggcagagtc tgagtgccgg cacagcaagc tcagtacagc agagcgtgag caggccctgc     1320

gcctgaagag ccgcgcggtg gagctgctgc ccgatgggac tgccaacctt gccaagctgc     1380

agcttgtggt ggagaatagt gcccagcggg tcatccactt ggcgggtcag tgggagaagc     1440

accgggtccc actcctcgct gagtaccgcc acctccgaaa gctgcaggat tgcagagagc     1500

tggaatcttc tcgacggctg gcagagatcc aagaactgca ccagagtgtc cgggcggctg     1560

ctgaagaggc ccgcaggaag gaggaggtct ataagcagct gatgtcagag ctggagactc     1620

tgcccagaga tgtgtcccgg ctggcctaca cccagcgcat cctggagatc gtgggcaaca     1680

tccggaagca gaaggaagag atcaccaaga tcttgtctga tacgaaggag cttcagaagg     1740

aaatcaactc cctatctggg aagctggacc ggacgtttgc ggtgactgat gagcttgtgt     1800

tcaaggatgc caagaaggac gatgctgttc ggaaggccta taagtatcta gctgctctgc     1860

acgagaactg cagccagctc atccagacca tcgaggacac aggcaccatc atgcgggagg     1920

ttcgagacct cgaggagcag atcgagacag agctgggcaa gaagaccctc agcaacctgg     1980

agaagatccg ggaggactac cgagccctcc gccaggagaa cgctggcctc ctaggccggg     2040

tccgggaggc ctgaggagcc gccggcagag gtctctcccc agcctcaggc agggatttgg     2100

ggtgctggag gcagtggcca agcacatgcc ctagctactt cctccgctgt ccagttcctc     2160

ctgctgcggc cttggaccca gacccctgcc cactgaccgc aacccttata tggggtgata     2220

gtccagcatg tggggagctc ggctgcagtt tattggggac ggtactgtgg gttgggggcc     2280

ttggatccca aataaatgag tagttcctct gcagtctaaa aaaaaaaaaa aaa            2333


<210> 240
<211> 627
<212> PRT
<213> Homo sapiens

<400> 240
Met Glu Glu Ala Asp Arg Ile Leu Ile His Ser Leu Arg Gln Ala Gly 
1               5                   10                  15      


Thr Ala Val Pro Pro Asp Val Gln Thr Leu Arg Ala Phe Thr Thr Glu 
            20                  25                  30          


Leu Val Val Glu Ala Val Val Arg Cys Leu Arg Val Ile Asn Pro Ala 
        35                  40                  45              


Val Gly Ser Gly Leu Ser Pro Leu Leu Pro Leu Ala Met Ser Ala Arg 
    50                  55                  60                  


Phe Arg Leu Ala Met Ser Leu Ala Gln Ala Cys Met Asp Leu Gly Tyr 
65                  70                  75                  80  


Pro Leu Glu Leu Gly Tyr Gln Asn Phe Leu Tyr Pro Ser Glu Pro Asp 
                85                  90                  95      


Leu Arg Asp Leu Leu Leu Phe Leu Ala Glu Arg Leu Pro Thr Asp Ala 
            100                 105                 110         


Ser Glu Asp Ala Asp Gln Pro Ala Gly Asp Ser Ala Ile Leu Leu Arg 
        115                 120                 125             


Ala Ile Gly Ser Gln Ile Arg Asp Gln Leu Ala Leu Pro Trp Val Pro 
    130                 135                 140                 


Pro His Leu Arg Thr Pro Lys Leu Gln His Leu Gln Gly Ser Ala Leu 
145                 150                 155                 160 


Gln Lys Pro Phe His Ala Ser Arg Leu Val Val Pro Glu Leu Ser Ser 
                165                 170                 175     


Arg Gly Glu Pro Arg Glu Phe Gln Ala Ser Pro Leu Leu Leu Pro Val 
            180                 185                 190         


Pro Thr Gln Val Pro Gln Pro Val Gly Arg Val Ala Ser Leu Leu Glu 
        195                 200                 205             


His His Ala Leu Gln Leu Cys Gln Gln Thr Gly Arg Asp Arg Pro Gly 
    210                 215                 220                 


Asp Glu Asp Trp Val His Arg Thr Ser Arg Leu Pro Pro Gln Glu Asp 
225                 230                 235                 240 


Thr Arg Ala Gln Arg Gln Arg Leu Gln Lys Gln Leu Thr Glu His Leu 
                245                 250                 255     


Arg Gln Ser Trp Gly Leu Leu Gly Ala Pro Ile Gln Ala Arg Asp Leu 
            260                 265                 270         


Gly Glu Leu Leu Gln Ala Trp Gly Ala Gly Ala Lys Thr Gly Ala Pro 
        275                 280                 285             


Lys Gly Ser Arg Phe Thr His Ser Glu Lys Phe Thr Phe His Leu Glu 
    290                 295                 300                 


Pro Gln Ala Gln Ala Thr Gln Val Ser Asp Val Pro Ala Thr Ser Arg 
305                 310                 315                 320 


Arg Pro Glu Gln Val Thr Trp Ala Ala Gln Glu Gln Glu Leu Glu Ser 
                325                 330                 335     


Leu Arg Glu Gln Leu Glu Gly Val Asn Arg Ser Ile Glu Glu Val Glu 
            340                 345                 350         


Ala Asp Met Lys Thr Leu Gly Val Ser Phe Val Gln Ala Glu Ser Glu 
        355                 360                 365             


Cys Arg His Ser Lys Leu Ser Thr Ala Glu Arg Glu Gln Ala Leu Arg 
    370                 375                 380                 


Leu Lys Ser Arg Ala Val Glu Leu Leu Pro Asp Gly Thr Ala Asn Leu 
385                 390                 395                 400 


Ala Lys Leu Gln Leu Val Val Glu Asn Ser Ala Gln Arg Val Ile His 
                405                 410                 415     


Leu Ala Gly Gln Trp Glu Lys His Arg Val Pro Leu Leu Ala Glu Tyr 
            420                 425                 430         


Arg His Leu Arg Lys Leu Gln Asp Cys Arg Glu Leu Glu Ser Ser Arg 
        435                 440                 445             


Arg Leu Ala Glu Ile Gln Glu Leu His Gln Ser Val Arg Ala Ala Ala 
    450                 455                 460                 


Glu Glu Ala Arg Arg Lys Glu Glu Val Tyr Lys Gln Leu Met Ser Glu 
465                 470                 475                 480 


Leu Glu Thr Leu Pro Arg Asp Val Ser Arg Leu Ala Tyr Thr Gln Arg 
                485                 490                 495     


Ile Leu Glu Ile Val Gly Asn Ile Arg Lys Gln Lys Glu Glu Ile Thr 
            500                 505                 510         


Lys Ile Leu Ser Asp Thr Lys Glu Leu Gln Lys Glu Ile Asn Ser Leu 
        515                 520                 525             


Ser Gly Lys Leu Asp Arg Thr Phe Ala Val Thr Asp Glu Leu Val Phe 
    530                 535                 540                 


Lys Asp Ala Lys Lys Asp Asp Ala Val Arg Lys Ala Tyr Lys Tyr Leu 
545                 550                 555                 560 


Ala Ala Leu His Glu Asn Cys Ser Gln Leu Ile Gln Thr Ile Glu Asp 
                565                 570                 575     


Thr Gly Thr Ile Met Arg Glu Val Arg Asp Leu Glu Glu Gln Ile Glu 
            580                 585                 590         


Thr Glu Leu Gly Lys Lys Thr Leu Ser Asn Leu Glu Lys Ile Arg Glu 
        595                 600                 605             


Asp Tyr Arg Ala Leu Arg Gln Glu Asn Ala Gly Leu Leu Gly Arg Val 
    610                 615                 620                 


Arg Glu Ala 
625         


<210> 241
<211> 4452
<212> DNA
<213> Homo sapiens

<400> 241
ttattttccc cggagagtcc cgaggcgccg cgccttggcc ctgcctacag cccgaggccc       60

cgcccccggc gcccctccca gccgtttgaa gcggctcggg ctgcggctgg ctcagagtgg      120

cgcggggggc gtggggcggt gctgaggagc tgaagccgtg gccagctcga cgccggacag      180

tccagcgagc agcacggcgg gaaccggcag ccggagcagt cccggagcag aagcagcagc      240

agcagcagca gccctcgccg ttcgcggagc gcagccgagc cggccatggc gttgtcgatg      300

ccgctgaatg ggctgaagga ggaggacaaa gagcccctca tcgagctctt cgtcaaggct      360

ggcagtgatg gtgaaagcat aggaaactgc cccttttccc agaggctctt catgattctt      420

tggctcaaag gagttgtatt tagtgtgacg actgttgacc tgaaaaggaa gccagcagac      480

ctgcagaact tggctcccgg gacccaccca ccatttataa ctttcaacag tgaagtcaaa      540

acggatgtaa ataagattga ggaatttctt gaagaagtct tatgccctcc caagtactta      600

aagctttcac caaaacaccc agaatcaaat actgctggaa tggacatctt tgccaaattc      660

tctgcatata tcaagaattc aaggccagag gctaatgaag cactggagag gggtctcctg      720

aaaaccctgc agaaactgga tgaatatctg aattctcctc tccctgatga aattgatgaa      780

aatagtatgg aggacataaa gttttctaca cgtaaatttc tggatggcaa tgaaatgaca      840

ttagctgatt gcaacctgct gcccaaactg catattgtca aggtggtggc caaaaaatat      900

cgcaactttg atattccaaa agaaatgact ggcatctgga gatacctaac taatgcatac      960

agtagggacg agttcaccaa tacctgtccc agtgataagg aggttgaaat agcatatagt     1020

gatgtagcca aaagactcac caagtaaaat cgcgtttgta aaagagatgt cttcatgtct     1080

tcccctaaga atacgctttt cctaacaggc tactccttcc tgtagagcag aaattgtatt     1140

ttgcacgaac atgcagttat tgaagattag gatcaaggat agacaaggta tagtagttat     1200

cttaaaatat acactcctaa gcagtattat tttaaaatcc tttaccctgg ctacctcccc     1260

tacccgggtt cccctctctt taatttggag acactccacc acaaactttt cactttagag     1320

gtagcttgcc atctctcagg agccctcacc attgtgtcca ttcactgtgt atagatggca     1380

gaacttttga ggtgcaatgt ttaattgtta aaaatagtag ccacgacttt atcaggcagc     1440

cccaaactgg tgcataatgc atggtacaag aaatatttat gtattttttg gaattttgta     1500

atatttagta agagtatatg aaaggattgc tactgtatca gaaatattgt ttcaatttag     1560

tctatcctgg atatgtacta acgaatatta ccaccagaga agagagcttt ctacaaaagt     1620

cactacagat tttgctatat tgctttgtag atagattttt acttttgcct aaaagcattt     1680

atccttcata ccaattgtaa catctgacac catgtagaag ctaaaagttt agagggagtg     1740

agggttttct caagaccttc ctcaagcatt ttatctttag aagagaaact gatgggcacc     1800

tgatactctg tctaaatacg tttgttatat gtgttttgcc ctgtgccatt catttggaac     1860

tttattgcat tctttatttt aaaaagcttg tttttacgta atcatagagc ttgctatttg     1920

tacatctgtt gagcaacact acataactga tttttagttg acttagctat agcagtacaa     1980

tgattagtaa tgtaaaaatt aacacagaaa ttaacctaag gaatgaaggg tgggtttgtc     2040

aaaatatcaa gtaaattttt gtttctaaag tacatttaat gtagatgacc taaagaatgc     2100

gttatccatc ctatataaaa gaaagataaa acacaggtca ccaattttct catttcaccc     2160

catttacctt gtatagagga ttgttcattc ctttgggact aagttatagt tatggtgagt     2220

gtgtatttac tgtagttttg cctgatctca ctcattgcac ttcctggagt taaattttcc     2280

aacagccatg ttgaggaata gcactctgca tgtttttgtt ttgtttttcg gggttttttt     2340

taattgaagc cctaaaccag gaattatttg tgttctaaca ggaggatgaa cttgctgaaa     2400

ataaaacttt gctatgtatt tactcttttt taaaagacaa aagcaaaacc agactttcta     2460

cgtactactc caaagactgt gattgtgact ataatacatt tttggtaatt tttttatacc     2520

taatttgtat aggaagtgct atttctcata ggctgtttct tgaaatttta agtttattgc     2580

tttaaaatgg cagtgtttct cccactttga tatgctaaca tttagtaagc actggcttta     2640

tgaaagcggc tttttataag tatactgcat tttttgagcc tatcattaat tagcttagta     2700

tgaaagataa gaaaatctcc atgttgtatc catttggctc aggaagattc tttgccttac     2760

ctttcttaga actctttatt gcttatcaaa agtttgagta cccgcttggt ttttttttgg     2820

taattaaata ttgtatgatt tatctggttc aaggaagatg cactattcag ttatctattg     2880

agaaattatt ttgcagtggt tttagtgggt gaaaatgtcc catctgcacc agtacacagg     2940

caggcattat cattcttcac ctacttttta aatagtggca acttgggatt cattctggtg     3000

attctgaacc ttgcctcata gcttaaagta taaaaaagat tcaagagcag tgaggtttgt     3060

tctttccagt gaatggtgga ctgagtggtg cgaggtggag ggctaacaag aggaaagaac     3120

tacattcttc agaatacagt gatgaaaatt cattttgaaa ctcaaatatt ttcattttgg     3180

atattctcct gtttttatta aaccagtgat tacacctggc catccctcta aatgttctag     3240

gaaggcatgt ctattgtgat tttgatgaag acagaattat ttttctctgt agaaacacag     3300

ataccacttt atcagggaag ttagtcaaat gaaatggaaa ttggtaaatg gacaaaagct     3360

agctagtaaa aaggacgacc cagcaacatg ctttaacccc attgtatgtt tgtggaaaga     3420

gcatagttta acatcttgag aaatttggga cataaagttt tcatggtaga cagttcatgc     3480

agtatatgaa ttgccataat ggaaataatc tgattttatt tttacaacta acatccattc     3540

cccttcattt aaacaccttt tgtgttttac ttcagtgagg agattggagt ctgaatggat     3600

ctgttttcca agagattctg agaaattttt gtattcagca gttggaaagc tctctattct     3660

agttgataaa acttcccttt tttgatgtag atgcagatat tctatacagt tctgttgtct     3720

tttactagga ctgtaaactt ttgtgataaa attcaaataa gattttattt cttggtaatt     3780

ttggctttca caatttatct ttaaatcctt gagcaatctg tatacaatta agagatttct     3840

gacatttatt cttacactaa atggatcaac tctaggattt aggcatgtta acttctgttg     3900

tgttttgaat ctctccagag ttgcatgtag atagcattta tttctgtgcc cttaaaccca     3960

tttagaaaat aactacaaag taaaaatgta gaggaaatag aaatgtattt tttcatgaac     4020

attttgatac aaatttcatc atttaatgat tcaccaattt cttgcattaa tttgaattta     4080

agcatttaat tcaaagagag gggagcatcc attattgata catgtgggct tttaaaaact     4140

ccatccttta taaatagtca aggtttgggc cacacaaagt atatttttat catggaaaaa     4200

tttcaactcc tcaagccgta atgttgaaca gaattggagt attttcttta taatttcttg     4260

aacaggcaaa tgaaagctta ttatagaatg catgtatttt cttttatctt tggaacatca     4320

gcaccagtat attgctggca gctattgtat taaaaaataa agtatatttt cactatcata     4380

aaggattctt ttttcccccc tcatgaaaat aaacaacaac ttggggtaaa agtgaaaaaa     4440

aaaaaaaaaa aa                                                         4452


<210> 242
<211> 253
<212> PRT
<213> Homo sapiens

<400> 242
Met Ala Leu Ser Met Pro Leu Asn Gly Leu Lys Glu Glu Asp Lys Glu 
1               5                   10                  15      


Pro Leu Ile Glu Leu Phe Val Lys Ala Gly Ser Asp Gly Glu Ser Ile 
            20                  25                  30          


Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met Ile Leu Trp Leu Lys 
        35                  40                  45              


Gly Val Val Phe Ser Val Thr Thr Val Asp Leu Lys Arg Lys Pro Ala 
    50                  55                  60                  


Asp Leu Gln Asn Leu Ala Pro Gly Thr His Pro Pro Phe Ile Thr Phe 
65                  70                  75                  80  


Asn Ser Glu Val Lys Thr Asp Val Asn Lys Ile Glu Glu Phe Leu Glu 
                85                  90                  95      


Glu Val Leu Cys Pro Pro Lys Tyr Leu Lys Leu Ser Pro Lys His Pro 
            100                 105                 110         


Glu Ser Asn Thr Ala Gly Met Asp Ile Phe Ala Lys Phe Ser Ala Tyr 
        115                 120                 125             


Ile Lys Asn Ser Arg Pro Glu Ala Asn Glu Ala Leu Glu Arg Gly Leu 
    130                 135                 140                 


Leu Lys Thr Leu Gln Lys Leu Asp Glu Tyr Leu Asn Ser Pro Leu Pro 
145                 150                 155                 160 


Asp Glu Ile Asp Glu Asn Ser Met Glu Asp Ile Lys Phe Ser Thr Arg 
                165                 170                 175     


Lys Phe Leu Asp Gly Asn Glu Met Thr Leu Ala Asp Cys Asn Leu Leu 
            180                 185                 190         


Pro Lys Leu His Ile Val Lys Val Val Ala Lys Lys Tyr Arg Asn Phe 
        195                 200                 205             


Asp Ile Pro Lys Glu Met Thr Gly Ile Trp Arg Tyr Leu Thr Asn Ala 
    210                 215                 220                 


Tyr Ser Arg Asp Glu Phe Thr Asn Thr Cys Pro Ser Asp Lys Glu Val 
225                 230                 235                 240 


Glu Ile Ala Tyr Ser Asp Val Ala Lys Arg Leu Thr Lys 
                245                 250             


<210> 243
<211> 3579
<212> DNA
<213> Homo sapiens

<400> 243
gatgacgtag gctgcgcctg tgcatgcgca gggaggggag accttggcgg agcggcggag       60

gcgcccagcg gaggtgaaag tattggcgga aaggaaaata cagcggaaaa atgcagagct      120

ggagtcgtgt gtactgctcc ttggccaaga gaggccattt caatcgaata tctcatggcc      180

tacagggact ttctgcagtg cctctgagaa cttacgcaga tcagccgatt gatgctgatg      240

taacagttat aggttctggt cctggaggat atgttgctgc tattaaagct gcccagttag      300

gcttcaagac agtctgcatt gagaaaaatg aaacacttgg tggaacatgc ttgaatgttg      360

gttgtattcc ttctaaggct ttattgaaca actctcatta ttaccatatg gcccatggaa      420

aagattttgc atctagagga attgaaatgt ccgaagttcg cttgaattta gacaagatga      480

tggagcagaa gagtactgca gtaaaagctt taacaggtgg aattgcccac ttattcaaac      540

agaataaggt tgttcatgtc aatggatatg gaaagataac tggcaaaaat caagtcactg      600

ctacgaaagc tgatggcggc actcaggtta ttgatacaaa gaacattctt atagccacgg      660

gttcagaagt tactcctttt cctggaatca cgatagatga agatacaata gtgtcatcta      720

caggtgcttt atctttaaaa aaagttccag aaaagatggt tgttattggt gcaggagtaa      780

taggtgtaga attgggttca gtttggcaaa gacttggtgc agatgtgaca gcagttgaat      840

ttttaggtca tgtaggtgga gttggaattg atatggagat atctaaaaac tttcaacgca      900

tccttcaaaa acaggggttt aaatttaaat tgaatacaaa ggttactggt gctaccaaga      960

agtcagatgg aaaaattgat gtttctattg aagctgcttc tggtggtaaa gctgaagtta     1020

tcacttgtga tgtactcttg gtttgcattg gccgacgacc ctttactaag aatttgggac     1080

tagaagagct gggaattgaa ctagatccca gaggtagaat tccagtcaat accagatttc     1140

aaactaaaat tccaaatatc tatgccattg gtgatgtagt tgctggtcca atgctggctc     1200

acaaagcaga ggatgaaggc attatctgtg ttgaaggaat ggctggtggt gctgtgcaca     1260

ttgactacaa ttgtgtgcca tcagtgattt acacacaccc tgaagttgct tgggttggca     1320

aatcagaaga gcagttgaaa gaagagggta ttgagtacaa agttgggaaa ttcccatttg     1380

ctgctaacag cagagctaag acaaatgctg acacagatgg catggtgaag atccttgggc     1440

agaaatcgac agacagagta ctgggagcac atattcttgg accaggtgct ggagaaatgg     1500

taaatgaagc tgctcttgct ttggaatatg gagcatcctg tgaagatata gctagagtct     1560

gtcatgcaca tccgacctta tcagaagctt ttagagaagc aaatcttgct gcgtcatttg     1620

gcaaatcaat caacttttga attagaagat tatatatatt tttttctgaa atttcctggg     1680

agcttttgta gaagtcacat tcctgaacag gatattctca cagctccaag aatttctagg     1740

actgaattat gaaacttttg gaaggtattt aataggtttg gacaaaatgg aatactctta     1800

tatctatatt ttacataaat ttagtatttt gtttcagtgc actaatgtgt aagacaaaaa     1860

gctacttatt gtagcatcct ggaatatctc cgtcaactca tattttcatg ctgttcatga     1920

aagattcaat gcccctgaat ttaaatagct tttttctctg atacagaaaa gttgaatttt     1980

acatggctgg agctagaatt tgatatgtga acagttgtgt ttgaagcaca gtgatcaagt     2040

tatttttaat ttggttttca cattggaaac aagtcagtca ttcagatatg attcaaatgt     2100

ctataaaccg aactgatgta agtaaacggt ctctcacttg ttttatttaa cctctaaatt     2160

ctttcatttt aggggtagca tttgtgttga agaggtttta aagcttccat tgttgtctgc     2220

aactctgaag ggtaattata tagttaccca aattaagaga gtctatttac ggaactcaaa     2280

tacgtgggca ttcaaatgta ttacagtggg gaatgaagat actgaaataa acgtcttaaa     2340

tattcattta ctggttatca tgagtacgtg ttgagatggt catagttttt tttatgacta     2400

cttctagtgt atattctaat ttcttttcta ggcctgaatg tatctttatt ttcatgttat     2460

aggacaatat taaggcattt taaaggtcat catcctttca tctattttag atacacctac     2520

taaatgttta atatatactt ttggagaagt acaacataag ggagtcttta atctgtgttt     2580

tccttggctg ggttaatgac tgtttattta aagagtgttg taaaattgga tgtgtggtgt     2640

ttaaaatggc catgtcctga ggaaacttaa gtaacaaagt actaaatgct aagtaggctt     2700

ttgcatattg taactaaatt taagaataat tcagattaag tagttctgaa atttggtata     2760

gatagcatag attgtctcat gctcatgagt gacataatga ccctggattc tgttacatac     2820

ttctaaagaa aattgattgt tgtcttagga ggcagttaac ttggctgaac accaactcca     2880

cactctgtct tgtttgtagg tggcagcagc tgaaatctct tctcagttgt tttagcttta     2940

gctatgctgc tggaagtctt tcccatgcaa gtgtgtagtt caggggtcaa ccagagtttg     3000

ggcagaagga agtctgcccc ttctgtgcct cctgtttttt gggggtttcc cctttatgtt     3060

ccagctgttg tggttgcccc atattctgcc ttctgatcct taaccaataa aacttggctt     3120

ttgtttcccc ctcaagtgag aacccgttaa aaatgagaca ttgagccagt gctgttcact     3180

ttttaagtgc caacttccct ctactttcca cttgtttata gttgtttcca gtgcctttag     3240

ttttttctaa aatatatttg ttcagagttt gcagttgcta tcagcaggag ggttggtctg     3300

atatctgtgt gctactttgc cattattgga agtgaactct gcatcttttt aaaaatttga     3360

aatcccggta tcatgtgaag tgctgtttat gtaaatctca acatatccct tactcaggga     3420

aaaaaaagtt tttagttagg gaatagtgaa atataattta atatggaatt ctagctgtag     3480

agttaaatcc atctttaagt gtttacattc agtatgagaa tgcaaattta tctgtatggg     3540

gaataaagtc ctaggaataa aacaagtttt aagtgttca                            3579


<210> 244
<211> 509
<212> PRT
<213> Homo sapiens

<400> 244
Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His 
1               5                   10                  15      


Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu 
            20                  25                  30          


Arg Thr Tyr Ala Asp Gln Pro Ile Asp Ala Asp Val Thr Val Ile Gly 
        35                  40                  45              


Ser Gly Pro Gly Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu Gly 
    50                  55                  60                  


Phe Lys Thr Val Cys Ile Glu Lys Asn Glu Thr Leu Gly Gly Thr Cys 
65                  70                  75                  80  


Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser His 
                85                  90                  95      


Tyr Tyr His Met Ala His Gly Lys Asp Phe Ala Ser Arg Gly Ile Glu 
            100                 105                 110         


Met Ser Glu Val Arg Leu Asn Leu Asp Lys Met Met Glu Gln Lys Ser 
        115                 120                 125             


Thr Ala Val Lys Ala Leu Thr Gly Gly Ile Ala His Leu Phe Lys Gln 
    130                 135                 140                 


Asn Lys Val Val His Val Asn Gly Tyr Gly Lys Ile Thr Gly Lys Asn 
145                 150                 155                 160 


Gln Val Thr Ala Thr Lys Ala Asp Gly Gly Thr Gln Val Ile Asp Thr 
                165                 170                 175     


Lys Asn Ile Leu Ile Ala Thr Gly Ser Glu Val Thr Pro Phe Pro Gly 
            180                 185                 190         


Ile Thr Ile Asp Glu Asp Thr Ile Val Ser Ser Thr Gly Ala Leu Ser 
        195                 200                 205             


Leu Lys Lys Val Pro Glu Lys Met Val Val Ile Gly Ala Gly Val Ile 
    210                 215                 220                 


Gly Val Glu Leu Gly Ser Val Trp Gln Arg Leu Gly Ala Asp Val Thr 
225                 230                 235                 240 


Ala Val Glu Phe Leu Gly His Val Gly Gly Val Gly Ile Asp Met Glu 
                245                 250                 255     


Ile Ser Lys Asn Phe Gln Arg Ile Leu Gln Lys Gln Gly Phe Lys Phe 
            260                 265                 270         


Lys Leu Asn Thr Lys Val Thr Gly Ala Thr Lys Lys Ser Asp Gly Lys 
        275                 280                 285             


Ile Asp Val Ser Ile Glu Ala Ala Ser Gly Gly Lys Ala Glu Val Ile 
    290                 295                 300                 


Thr Cys Asp Val Leu Leu Val Cys Ile Gly Arg Arg Pro Phe Thr Lys 
305                 310                 315                 320 


Asn Leu Gly Leu Glu Glu Leu Gly Ile Glu Leu Asp Pro Arg Gly Arg 
                325                 330                 335     


Ile Pro Val Asn Thr Arg Phe Gln Thr Lys Ile Pro Asn Ile Tyr Ala 
            340                 345                 350         


Ile Gly Asp Val Val Ala Gly Pro Met Leu Ala His Lys Ala Glu Asp 
        355                 360                 365             


Glu Gly Ile Ile Cys Val Glu Gly Met Ala Gly Gly Ala Val His Ile 
    370                 375                 380                 


Asp Tyr Asn Cys Val Pro Ser Val Ile Tyr Thr His Pro Glu Val Ala 
385                 390                 395                 400 


Trp Val Gly Lys Ser Glu Glu Gln Leu Lys Glu Glu Gly Ile Glu Tyr 
                405                 410                 415     


Lys Val Gly Lys Phe Pro Phe Ala Ala Asn Ser Arg Ala Lys Thr Asn 
            420                 425                 430         


Ala Asp Thr Asp Gly Met Val Lys Ile Leu Gly Gln Lys Ser Thr Asp 
        435                 440                 445             


Arg Val Leu Gly Ala His Ile Leu Gly Pro Gly Ala Gly Glu Met Val 
    450                 455                 460                 


Asn Glu Ala Ala Leu Ala Leu Glu Tyr Gly Ala Ser Cys Glu Asp Ile 
465                 470                 475                 480 


Ala Arg Val Cys His Ala His Pro Thr Leu Ser Glu Ala Phe Arg Glu 
                485                 490                 495     


Ala Asn Leu Ala Ala Ser Phe Gly Lys Ser Ile Asn Phe 
            500                 505                 


<210> 245
<211> 2656
<212> DNA
<213> Homo sapiens

<400> 245
gtgtgtgtgg cgcctgcgca gtggcggtga ccaccggctc gcggcgcgtg gaggctgctc       60

ccagccgcgc gcgagtcaga ctcgggtggg ggtcccggcg gcggtagcgg cggcggcggt      120

gcgagcatgt cgtggctctt cggcattaac aagggcccca agggtgaagg cgcggggccg      180

ccgccgcctt tgccgcccgc gcagcccggg gccgagggcg gcggggaccg cgggttggga      240

gaccggccgg cgcccaagga caaatggagc aacttcgacc ccaccggcct ggagcgcgcc      300

gccaaggcgg cgcgcgagct ggagcactcg cgttatgcca aggacgccct gaatctggca      360

cagatgcagg agcagacgct gcagttggag caacagtcca agctcaaaat gcggctggaa      420

gccctgagcc tgctgcacac actagtctgg gcatggagtc tctgccgtgc cggagccgtg      480

cagacacagg agcggctgtc aggcagtgcc agccctgagc aagtgccagc tggtgagtgc      540

tgtgctctgc aggagtatga ggccgccgtg gagcagctca agagcgagca gatccgggcg      600

caggctgagg agaggaggaa gaccctgagc gaggagaccc ggcagcacca ggccagggcc      660

cagtatcaag acaagctggc ccggcagcgc tacgaggacc aactgaagca gcagcaactt      720

ctcaatgagg agaatttacg gaagcaggag gagtccgtgc agaagcagga agccatgcgg      780

cgagccaccg tggagcggga gatggagctg cggcacaaga atgagatgct gcgagtggag      840

gccgaggccc gggcgcgcgc caaggccgag cgggagaatg cagacatcat ccgcgagcag      900

atccgcctga aggcggccga gcaccgtcag accgtcttgg agtccatcag gacggctggc      960

accttgtttg gggaaggatt ccgtgccttt gtgacagact gggacaaagt gacagccacg     1020

gtggctgggc tgacgctgct ggctgttggg gtctactcag ccaagaatgc cacgcttgtc     1080

gccggccgct tcatcgaggc tcggctgggg aagccgtccc tagtgaggga gacgtcccgc     1140

atcacggtgc ttgaggcgct gcggcacccc atccaggtca gccggcggct cctcagtcga     1200

ccccaggacg cgctggaggg tgttgtgctc agtcccagcc tggaagcacg ggtgcgcgac     1260

atcgccatag caacaaggaa caccaagaag aaccgcagcc tgtacaggaa catcctgatg     1320

tacgggccac caggcaccgg gaagacgctg tttgccaaga aactcgccct gcactcaggc     1380

atggactacg ccatcatgac aggcggggac gtggccccca tggggcggga aggcgtgacc     1440

gccatgcaca agctctttga ctgggccaat accagccggc gcggcctcct gctctttgtg     1500

gatgaagcgg acgccttcct tcggaagcga gccaccgaga agataagcga ggacctcagg     1560

gccacactga acgccttcct gtaccgcacg ggccagcaca gcaacaagtt catgctggtc     1620

ctggccagca accaaccaga gcagttcgac tgggccatca atgaccgcat caatgagatg     1680

gtccacttcg acctgccagg gcaggaggaa cgggagcgcc tggtgagaat gtattttgac     1740

aagtatgttc ttaagccggc cacagaagga aagcagcgcc tgaagctggc ccagtttgac     1800

tacgggagga agtgctcgga ggtcgctcgg ctgacggagg gcatgtcggg ccgggagatc     1860

gctcagctgg ccgtgtcctg gcaggccacg gcgtatgcct ccgaggacgg ggtcctgacc     1920

gaggccatga tggacacccg cgtgcaagat gctgtccagc agcaccagca gaagatgtgc     1980

tggctgaagg cggaagggcc tgggcgtggg gacgagccct ccccatcctg agtccacagg     2040

gagatccaca gctcacggag cctggccgcg gacccctccc acccctgcct tgccggcccc     2100

tgcacattta ggatatgctc ctgggtgggg actgggctgt gcccagggcc tctgtccccc     2160

aggatgtctt gtggtgcggg tcggccgttc tgccccccag ggcaccccct gttgtaggca     2220

ctggctaggg aggggcaggc ctccttcctg cccctcgaga cactcttggg agatgcattt     2280

tccgtctggc tcacaggggg agggtgaggc tttgcacccc agcccctgcc caggccactg     2340

tgagggtggg tgctggctga gcccccgggg cagcaggagc caggcaggtg atgtctttgt     2400

tctcggctcc cacagcagag ccaggtgagg gggcgcctgc cagggccaga cccaggtggg     2460

gcagcctgaa ccctgcttcc ccctgtggcc ggcatgcccc gatctttcac acactggtga     2520

ccctgagaga ggagggagga gggaacctgg cgggggtgtc tgaggccgca ctgtcagctg     2580

gccggtccaa gcctgtggct ggagctgggg tctgtttacc taataaagtc ccacaggtgc     2640

ctcattaaaa aaaaaa                                                     2656


<210> 246
<211> 634
<212> PRT
<213> Homo sapiens

<400> 246
Met Ser Trp Leu Phe Gly Ile Asn Lys Gly Pro Lys Gly Glu Gly Ala 
1               5                   10                  15      


Gly Pro Pro Pro Pro Leu Pro Pro Ala Gln Pro Gly Ala Glu Gly Gly 
            20                  25                  30          


Gly Asp Arg Gly Leu Gly Asp Arg Pro Ala Pro Lys Asp Lys Trp Ser 
        35                  40                  45              


Asn Phe Asp Pro Thr Gly Leu Glu Arg Ala Ala Lys Ala Ala Arg Glu 
    50                  55                  60                  


Leu Glu His Ser Arg Tyr Ala Lys Asp Ala Leu Asn Leu Ala Gln Met 
65                  70                  75                  80  


Gln Glu Gln Thr Leu Gln Leu Glu Gln Gln Ser Lys Leu Lys Met Arg 
                85                  90                  95      


Leu Glu Ala Leu Ser Leu Leu His Thr Leu Val Trp Ala Trp Ser Leu 
            100                 105                 110         


Cys Arg Ala Gly Ala Val Gln Thr Gln Glu Arg Leu Ser Gly Ser Ala 
        115                 120                 125             


Ser Pro Glu Gln Val Pro Ala Gly Glu Cys Cys Ala Leu Gln Glu Tyr 
    130                 135                 140                 


Glu Ala Ala Val Glu Gln Leu Lys Ser Glu Gln Ile Arg Ala Gln Ala 
145                 150                 155                 160 


Glu Glu Arg Arg Lys Thr Leu Ser Glu Glu Thr Arg Gln His Gln Ala 
                165                 170                 175     


Arg Ala Gln Tyr Gln Asp Lys Leu Ala Arg Gln Arg Tyr Glu Asp Gln 
            180                 185                 190         


Leu Lys Gln Gln Gln Leu Leu Asn Glu Glu Asn Leu Arg Lys Gln Glu 
        195                 200                 205             


Glu Ser Val Gln Lys Gln Glu Ala Met Arg Arg Ala Thr Val Glu Arg 
    210                 215                 220                 


Glu Met Glu Leu Arg His Lys Asn Glu Met Leu Arg Val Glu Ala Glu 
225                 230                 235                 240 


Ala Arg Ala Arg Ala Lys Ala Glu Arg Glu Asn Ala Asp Ile Ile Arg 
                245                 250                 255     


Glu Gln Ile Arg Leu Lys Ala Ala Glu His Arg Gln Thr Val Leu Glu 
            260                 265                 270         


Ser Ile Arg Thr Ala Gly Thr Leu Phe Gly Glu Gly Phe Arg Ala Phe 
        275                 280                 285             


Val Thr Asp Trp Asp Lys Val Thr Ala Thr Val Ala Gly Leu Thr Leu 
    290                 295                 300                 


Leu Ala Val Gly Val Tyr Ser Ala Lys Asn Ala Thr Leu Val Ala Gly 
305                 310                 315                 320 


Arg Phe Ile Glu Ala Arg Leu Gly Lys Pro Ser Leu Val Arg Glu Thr 
                325                 330                 335     


Ser Arg Ile Thr Val Leu Glu Ala Leu Arg His Pro Ile Gln Val Ser 
            340                 345                 350         


Arg Arg Leu Leu Ser Arg Pro Gln Asp Ala Leu Glu Gly Val Val Leu 
        355                 360                 365             


Ser Pro Ser Leu Glu Ala Arg Val Arg Asp Ile Ala Ile Ala Thr Arg 
    370                 375                 380                 


Asn Thr Lys Lys Asn Arg Ser Leu Tyr Arg Asn Ile Leu Met Tyr Gly 
385                 390                 395                 400 


Pro Pro Gly Thr Gly Lys Thr Leu Phe Ala Lys Lys Leu Ala Leu His 
                405                 410                 415     


Ser Gly Met Asp Tyr Ala Ile Met Thr Gly Gly Asp Val Ala Pro Met 
            420                 425                 430         


Gly Arg Glu Gly Val Thr Ala Met His Lys Leu Phe Asp Trp Ala Asn 
        435                 440                 445             


Thr Ser Arg Arg Gly Leu Leu Leu Phe Val Asp Glu Ala Asp Ala Phe 
    450                 455                 460                 


Leu Arg Lys Arg Ala Thr Glu Lys Ile Ser Glu Asp Leu Arg Ala Thr 
465                 470                 475                 480 


Leu Asn Ala Phe Leu Tyr Arg Thr Gly Gln His Ser Asn Lys Phe Met 
                485                 490                 495     


Leu Val Leu Ala Ser Asn Gln Pro Glu Gln Phe Asp Trp Ala Ile Asn 
            500                 505                 510         


Asp Arg Ile Asn Glu Met Val His Phe Asp Leu Pro Gly Gln Glu Glu 
        515                 520                 525             


Arg Glu Arg Leu Val Arg Met Tyr Phe Asp Lys Tyr Val Leu Lys Pro 
    530                 535                 540                 


Ala Thr Glu Gly Lys Gln Arg Leu Lys Leu Ala Gln Phe Asp Tyr Gly 
545                 550                 555                 560 


Arg Lys Cys Ser Glu Val Ala Arg Leu Thr Glu Gly Met Ser Gly Arg 
                565                 570                 575     


Glu Ile Ala Gln Leu Ala Val Ser Trp Gln Ala Thr Ala Tyr Ala Ser 
            580                 585                 590         


Glu Asp Gly Val Leu Thr Glu Ala Met Met Asp Thr Arg Val Gln Asp 
        595                 600                 605             


Ala Val Gln Gln His Gln Gln Lys Met Cys Trp Leu Lys Ala Glu Gly 
    610                 615                 620                 


Pro Gly Arg Gly Asp Glu Pro Ser Pro Ser 
625                 630                 


<210> 247
<211> 2512
<212> DNA
<213> Homo sapiens

<400> 247
gtgtgtgtgg cgcctgcgca gtggcggtga ccaccggctc gcggcgcgtg gaggctgctc       60

ccagccgcgc gcgagtcaga ctcgggtggg ggtcccggcg gcggtagcgg cggcggcggt      120

gcgagcatgt cgtggctctt cggcattaac aagggcccca agggtgaagg cgcggggccg      180

ccgccgcctt tgccgcccgc gcagcccggg gccgagggcg gcggggaccg cgggttggga      240

gaccggccgg cgcccaagga caaatggagc aacttcgacc ccaccggcct ggagcgcgcc      300

gccaaggcgg cgcgcgagct ggagcactcg cgttatgcca aggacgccct gaatctggca      360

cagatgcagg agcagacgct gcagttggag caacagtcca agctcaaaga gtatgaggcc      420

gccgtggagc agctcaagag cgagcagatc cgggcgcagg ctgaggagag gaggaagacc      480

ctgagcgagg agacccggca gcaccaggcc agggcccagt atcaagacaa gctggcccgg      540

cagcgctacg aggaccaact gaagcagcag caacttctca atgaggagaa tttacggaag      600

caggaggagt ccgtgcagaa gcaggaagcc atgcggcgag ccaccgtgga gcgggagatg      660

gagctgcggc acaagaatga gatgctgcga gtggaggccg aggcccgggc gcgcgccaag      720

gccgagcggg agaatgcaga catcatccgc gagcagatcc gcctgaaggc ggccgagcac      780

cgtcagaccg tcttggagtc catcaggacg gctggcacct tgtttgggga aggattccgt      840

gcctttgtga cagactggga caaagtgaca gccacggtgg ctgggctgac gctgctggct      900

gttggggtct actcagccaa gaatgccacg cttgtcgccg gccgcttcat cgaggctcgg      960

ctggggaagc cgtccctagt gagggagacg tcccgcatca cggtgcttga ggcgctgcgg     1020

caccccatcc aggtcagccg gcggctcctc agtcgacccc aggacgcgct ggagggtgtt     1080

gtgctcagtc ccagcctgga agcacgggtg cgcgacatcg ccatagcaac aaggaacacc     1140

aagaagaacc gcagcctgta caggaacatc ctgatgtacg ggccaccagg caccgggaag     1200

acgctgtttg ccaagaaact cgccctgcac tcaggcatgg actacgccat catgacaggc     1260

ggggacgtgg cccccatggg gcgggaaggc gtgaccgcca tgcacaagct ctttgactgg     1320

gccaatacca gccggcgcgg cctcctgctc tttgtggatg aagcggacgc cttccttcgg     1380

aagcgagcca ccgagaagat aagcgaggac ctcagggcca cactgaacgc cttcctgtac     1440

cgcacgggcc agcacagcaa caagttcatg ctggtcctgg ccagcaacca accagagcag     1500

ttcgactggg ccatcaatga ccgcatcaat gagatggtcc acttcgacct gccagggcag     1560

gaggaacggg agcgcctggt gagaatgtat tttgacaagt atgttcttaa gccggccaca     1620

gaaggaaagc agcgcctgaa gctggcccag tttgactacg ggaggaagtg ctcggaggtc     1680

gctcggctga cggagggcat gtcgggccgg gagatcgctc agctggccgt gtcctggcag     1740

gccacggcgt atgcctccga ggacggggtc ctgaccgagg ccatgatgga cacccgcgtg     1800

caagatgctg tccagcagca ccagcagaag atgtgctggc tgaaggcgga agggcctggg     1860

cgtggggacg agccctcccc atcctgagtc cacagggaga tccacagctc acggagcctg     1920

gccgcggacc cctcccaccc ctgccttgcc ggcccctgca catttaggat atgctcctgg     1980

gtggggactg ggctgtgccc agggcctctg tcccccagga tgtcttgtgg tgcgggtcgg     2040

ccgttctgcc ccccagggca ccccctgttg taggcactgg ctagggaggg gcaggcctcc     2100

ttcctgcccc tcgagacact cttgggagat gcattttccg tctggctcac agggggaggg     2160

tgaggctttg caccccagcc cctgcccagg ccactgtgag ggtgggtgct ggctgagccc     2220

ccggggcagc aggagccagg caggtgatgt ctttgttctc ggctcccaca gcagagccag     2280

gtgagggggc gcctgccagg gccagaccca ggtggggcag cctgaaccct gcttccccct     2340

gtggccggca tgccccgatc tttcacacac tggtgaccct gagagaggag ggaggaggga     2400

acctggcggg ggtgtctgag gccgcactgt cagctggccg gtccaagcct gtggctggag     2460

ctggggtctg tttacctaat aaagtcccac aggtgcctca ttaaaaaaaa aa             2512


<210> 248
<211> 586
<212> PRT
<213> Homo sapiens

<400> 248
Met Ser Trp Leu Phe Gly Ile Asn Lys Gly Pro Lys Gly Glu Gly Ala 
1               5                   10                  15      


Gly Pro Pro Pro Pro Leu Pro Pro Ala Gln Pro Gly Ala Glu Gly Gly 
            20                  25                  30          


Gly Asp Arg Gly Leu Gly Asp Arg Pro Ala Pro Lys Asp Lys Trp Ser 
        35                  40                  45              


Asn Phe Asp Pro Thr Gly Leu Glu Arg Ala Ala Lys Ala Ala Arg Glu 
    50                  55                  60                  


Leu Glu His Ser Arg Tyr Ala Lys Asp Ala Leu Asn Leu Ala Gln Met 
65                  70                  75                  80  


Gln Glu Gln Thr Leu Gln Leu Glu Gln Gln Ser Lys Leu Lys Glu Tyr 
                85                  90                  95      


Glu Ala Ala Val Glu Gln Leu Lys Ser Glu Gln Ile Arg Ala Gln Ala 
            100                 105                 110         


Glu Glu Arg Arg Lys Thr Leu Ser Glu Glu Thr Arg Gln His Gln Ala 
        115                 120                 125             


Arg Ala Gln Tyr Gln Asp Lys Leu Ala Arg Gln Arg Tyr Glu Asp Gln 
    130                 135                 140                 


Leu Lys Gln Gln Gln Leu Leu Asn Glu Glu Asn Leu Arg Lys Gln Glu 
145                 150                 155                 160 


Glu Ser Val Gln Lys Gln Glu Ala Met Arg Arg Ala Thr Val Glu Arg 
                165                 170                 175     


Glu Met Glu Leu Arg His Lys Asn Glu Met Leu Arg Val Glu Ala Glu 
            180                 185                 190         


Ala Arg Ala Arg Ala Lys Ala Glu Arg Glu Asn Ala Asp Ile Ile Arg 
        195                 200                 205             


Glu Gln Ile Arg Leu Lys Ala Ala Glu His Arg Gln Thr Val Leu Glu 
    210                 215                 220                 


Ser Ile Arg Thr Ala Gly Thr Leu Phe Gly Glu Gly Phe Arg Ala Phe 
225                 230                 235                 240 


Val Thr Asp Trp Asp Lys Val Thr Ala Thr Val Ala Gly Leu Thr Leu 
                245                 250                 255     


Leu Ala Val Gly Val Tyr Ser Ala Lys Asn Ala Thr Leu Val Ala Gly 
            260                 265                 270         


Arg Phe Ile Glu Ala Arg Leu Gly Lys Pro Ser Leu Val Arg Glu Thr 
        275                 280                 285             


Ser Arg Ile Thr Val Leu Glu Ala Leu Arg His Pro Ile Gln Val Ser 
    290                 295                 300                 


Arg Arg Leu Leu Ser Arg Pro Gln Asp Ala Leu Glu Gly Val Val Leu 
305                 310                 315                 320 


Ser Pro Ser Leu Glu Ala Arg Val Arg Asp Ile Ala Ile Ala Thr Arg 
                325                 330                 335     


Asn Thr Lys Lys Asn Arg Ser Leu Tyr Arg Asn Ile Leu Met Tyr Gly 
            340                 345                 350         


Pro Pro Gly Thr Gly Lys Thr Leu Phe Ala Lys Lys Leu Ala Leu His 
        355                 360                 365             


Ser Gly Met Asp Tyr Ala Ile Met Thr Gly Gly Asp Val Ala Pro Met 
    370                 375                 380                 


Gly Arg Glu Gly Val Thr Ala Met His Lys Leu Phe Asp Trp Ala Asn 
385                 390                 395                 400 


Thr Ser Arg Arg Gly Leu Leu Leu Phe Val Asp Glu Ala Asp Ala Phe 
                405                 410                 415     


Leu Arg Lys Arg Ala Thr Glu Lys Ile Ser Glu Asp Leu Arg Ala Thr 
            420                 425                 430         


Leu Asn Ala Phe Leu Tyr Arg Thr Gly Gln His Ser Asn Lys Phe Met 
        435                 440                 445             


Leu Val Leu Ala Ser Asn Gln Pro Glu Gln Phe Asp Trp Ala Ile Asn 
    450                 455                 460                 


Asp Arg Ile Asn Glu Met Val His Phe Asp Leu Pro Gly Gln Glu Glu 
465                 470                 475                 480 


Arg Glu Arg Leu Val Arg Met Tyr Phe Asp Lys Tyr Val Leu Lys Pro 
                485                 490                 495     


Ala Thr Glu Gly Lys Gln Arg Leu Lys Leu Ala Gln Phe Asp Tyr Gly 
            500                 505                 510         


Arg Lys Cys Ser Glu Val Ala Arg Leu Thr Glu Gly Met Ser Gly Arg 
        515                 520                 525             


Glu Ile Ala Gln Leu Ala Val Ser Trp Gln Ala Thr Ala Tyr Ala Ser 
    530                 535                 540                 


Glu Asp Gly Val Leu Thr Glu Ala Met Met Asp Thr Arg Val Gln Asp 
545                 550                 555                 560 


Ala Val Gln Gln His Gln Gln Lys Met Cys Trp Leu Lys Ala Glu Gly 
                565                 570                 575     


Pro Gly Arg Gly Asp Glu Pro Ser Pro Ser 
            580                 585     


<210> 249
<211> 2342
<212> DNA
<213> Homo sapiens

<400> 249
gggagccctg gcccttgccg ctcctcgccg ctgtcggcag ccacttcccg ggcgagactg       60

cgcccccgga gcacccccgg ccggagccgt gtcgcgtgcc gggaggatcg gactctttcc      120

gtcacccgtt tgcacctctg cagctgtcag gagcgggtca ggttatgcca aggacgccct      180

gaatctggca cagatgcagg agcagacgct gcagttggag caacagtcca agctcaaaga      240

gtatgaggcc gccgtggagc agctcaagag cgagcagatc cgggcgcagg ctgaggagag      300

gaggaagacc ctgagcgagg agacccggca gcaccaggcc agggcccagt atcaagacaa      360

gctggcccgg cagcgctacg aggaccaact gaagcagcag caacttctca atgaggagaa      420

tttacggaag caggaggagt ccgtgcagaa gcaggaagcc atgcggcgag ccaccgtgga      480

gcgggagatg gagctgcggc acaagaatga gatgctgcga gtggaggccg aggcccgggc      540

gcgcgccaag gccgagcggg agaatgcaga catcatccgc gagcagatcc gcctgaaggc      600

ggccgagcac cgtcagaccg tcttggagtc catcaggacg gctggcacct tgtttgggga      660

aggattccgt gcctttgtga cagactggga caaagtgaca gccacggtgg ctgggctgac      720

gctgctggct gttggggtct actcagccaa gaatgccacg cttgtcgccg gccgcttcat      780

cgaggctcgg ctggggaagc cgtccctagt gagggagacg tcccgcatca cggtgcttga      840

ggcgctgcgg caccccatcc aggtcagccg gcggctcctc agtcgacccc aggacgcgct      900

ggagggtgtt gtgctcagtc ccagcctgga agcacgggtg cgcgacatcg ccatagcaac      960

aaggaacacc aagaagaacc gcagcctgta caggaacatc ctgatgtacg ggccaccagg     1020

caccgggaag acgctgtttg ccaagaaact cgccctgcac tcaggcatgg actacgccat     1080

catgacaggc ggggacgtgg cccccatggg gcgggaaggc gtgaccgcca tgcacaagct     1140

ctttgactgg gccaatacca gccggcgcgg cctcctgctc tttgtggatg aagcggacgc     1200

cttccttcgg aagcgagcca ccgagaagat aagcgaggac ctcagggcca cactgaacgc     1260

cttcctgtac cgcacgggcc agcacagcaa caagttcatg ctggtcctgg ccagcaacca     1320

accagagcag ttcgactggg ccatcaatga ccgcatcaat gagatggtcc acttcgacct     1380

gccagggcag gaggaacggg agcgcctggt gagaatgtat tttgacaagt atgttcttaa     1440

gccggccaca gaaggaaagc agcgcctgaa gctggcccag tttgactacg ggaggaagtg     1500

ctcggaggtc gctcggctga cggagggcat gtcgggccgg gagatcgctc agctggccgt     1560

gtcctggcag gccacggcgt atgcctccga ggacggggtc ctgaccgagg ccatgatgga     1620

cacccgcgtg caagatgctg tccagcagca ccagcagaag atgtgctggc tgaaggcgga     1680

agggcctggg cgtggggacg agccctcccc atcctgagtc cacagggaga tccacagctc     1740

acggagcctg gccgcggacc cctcccaccc ctgccttgcc ggcccctgca catttaggat     1800

atgctcctgg gtggggactg ggctgtgccc agggcctctg tcccccagga tgtcttgtgg     1860

tgcgggtcgg ccgttctgcc ccccagggca ccccctgttg taggcactgg ctagggaggg     1920

gcaggcctcc ttcctgcccc tcgagacact cttgggagat gcattttccg tctggctcac     1980

agggggaggg tgaggctttg caccccagcc cctgcccagg ccactgtgag ggtgggtgct     2040

ggctgagccc ccggggcagc aggagccagg caggtgatgt ctttgttctc ggctcccaca     2100

gcagagccag gtgagggggc gcctgccagg gccagaccca ggtggggcag cctgaaccct     2160

gcttccccct gtggccggca tgccccgatc tttcacacac tggtgaccct gagagaggag     2220

ggaggaggga acctggcggg ggtgtctgag gccgcactgt cagctggccg gtccaagcct     2280

gtggctggag ctggggtctg tttacctaat aaagtcccac aggtgcctca ttaaaaaaaa     2340

aa                                                                    2342


<210> 250
<211> 507
<212> PRT
<213> Homo sapiens

<400> 250
Met Gln Glu Gln Thr Leu Gln Leu Glu Gln Gln Ser Lys Leu Lys Glu 
1               5                   10                  15      


Tyr Glu Ala Ala Val Glu Gln Leu Lys Ser Glu Gln Ile Arg Ala Gln 
            20                  25                  30          


Ala Glu Glu Arg Arg Lys Thr Leu Ser Glu Glu Thr Arg Gln His Gln 
        35                  40                  45              


Ala Arg Ala Gln Tyr Gln Asp Lys Leu Ala Arg Gln Arg Tyr Glu Asp 
    50                  55                  60                  


Gln Leu Lys Gln Gln Gln Leu Leu Asn Glu Glu Asn Leu Arg Lys Gln 
65                  70                  75                  80  


Glu Glu Ser Val Gln Lys Gln Glu Ala Met Arg Arg Ala Thr Val Glu 
                85                  90                  95      


Arg Glu Met Glu Leu Arg His Lys Asn Glu Met Leu Arg Val Glu Ala 
            100                 105                 110         


Glu Ala Arg Ala Arg Ala Lys Ala Glu Arg Glu Asn Ala Asp Ile Ile 
        115                 120                 125             


Arg Glu Gln Ile Arg Leu Lys Ala Ala Glu His Arg Gln Thr Val Leu 
    130                 135                 140                 


Glu Ser Ile Arg Thr Ala Gly Thr Leu Phe Gly Glu Gly Phe Arg Ala 
145                 150                 155                 160 


Phe Val Thr Asp Trp Asp Lys Val Thr Ala Thr Val Ala Gly Leu Thr 
                165                 170                 175     


Leu Leu Ala Val Gly Val Tyr Ser Ala Lys Asn Ala Thr Leu Val Ala 
            180                 185                 190         


Gly Arg Phe Ile Glu Ala Arg Leu Gly Lys Pro Ser Leu Val Arg Glu 
        195                 200                 205             


Thr Ser Arg Ile Thr Val Leu Glu Ala Leu Arg His Pro Ile Gln Val 
    210                 215                 220                 


Ser Arg Arg Leu Leu Ser Arg Pro Gln Asp Ala Leu Glu Gly Val Val 
225                 230                 235                 240 


Leu Ser Pro Ser Leu Glu Ala Arg Val Arg Asp Ile Ala Ile Ala Thr 
                245                 250                 255     


Arg Asn Thr Lys Lys Asn Arg Ser Leu Tyr Arg Asn Ile Leu Met Tyr 
            260                 265                 270         


Gly Pro Pro Gly Thr Gly Lys Thr Leu Phe Ala Lys Lys Leu Ala Leu 
        275                 280                 285             


His Ser Gly Met Asp Tyr Ala Ile Met Thr Gly Gly Asp Val Ala Pro 
    290                 295                 300                 


Met Gly Arg Glu Gly Val Thr Ala Met His Lys Leu Phe Asp Trp Ala 
305                 310                 315                 320 


Asn Thr Ser Arg Arg Gly Leu Leu Leu Phe Val Asp Glu Ala Asp Ala 
                325                 330                 335     


Phe Leu Arg Lys Arg Ala Thr Glu Lys Ile Ser Glu Asp Leu Arg Ala 
            340                 345                 350         


Thr Leu Asn Ala Phe Leu Tyr Arg Thr Gly Gln His Ser Asn Lys Phe 
        355                 360                 365             


Met Leu Val Leu Ala Ser Asn Gln Pro Glu Gln Phe Asp Trp Ala Ile 
    370                 375                 380                 


Asn Asp Arg Ile Asn Glu Met Val His Phe Asp Leu Pro Gly Gln Glu 
385                 390                 395                 400 


Glu Arg Glu Arg Leu Val Arg Met Tyr Phe Asp Lys Tyr Val Leu Lys 
                405                 410                 415     


Pro Ala Thr Glu Gly Lys Gln Arg Leu Lys Leu Ala Gln Phe Asp Tyr 
            420                 425                 430         


Gly Arg Lys Cys Ser Glu Val Ala Arg Leu Thr Glu Gly Met Ser Gly 
        435                 440                 445             


Arg Glu Ile Ala Gln Leu Ala Val Ser Trp Gln Ala Thr Ala Tyr Ala 
    450                 455                 460                 


Ser Glu Asp Gly Val Leu Thr Glu Ala Met Met Asp Thr Arg Val Gln 
465                 470                 475                 480 


Asp Ala Val Gln Gln His Gln Gln Lys Met Cys Trp Leu Lys Ala Glu 
                485                 490                 495     


Gly Pro Gly Arg Gly Asp Glu Pro Ser Pro Ser 
            500                 505         


<210> 251
<211> 3187
<212> DNA
<213> Homo sapiens

<400> 251
cccagaccag cagaggcagc agccggagca gccgcagcct gcgccctctc ccgcccgccc       60

gccctccgcc cgcccgcccg ccctccgccg ccctccaccc gccccggggt ctctttcccc      120

cttcctcctc ctcctcctcc accccccctt cctcctccgc ccgcccgcgg ggcccccctc      180

gccttcccgc ccgcccctat tgttccgccc ccggcctccc gcccttcccc ttcccgcccg      240

ctcccctttt cccctcagtc gcctcgcgcc tgcagttttt ggctttcacc cccaaccagt      300

gaccaaagac ttgaccactc aaagtccagc tccccagaac actgctcgac atggacaccg      360

gtgtgattga aggtggatta aatgtcactc tcaccatccg gctacttatg catggaaagg      420

aagttggcag tatcatcgga aagaaaggag aatcagttaa gaagatgcgc gaggagagtg      480

gtgcacgtat caacatctca gaagggaatt gtcctgagag aattatcact ttggctggac      540

ccactaatgc catcttcaaa gcctttgcta tgatcattga caaactggaa gaggacataa      600

gcagctctat gaccaatagc acagctgcca gtagaccccc ggtcaccctg aggctggtgg      660

tccctgctag tcagtgtggc tctctcattg gaaaaggtgg atgcaagatc aaggaaatac      720

gagagagtac aggggctcag gtccaggtgg caggggatat gctacccaac tcaactgagc      780

gggccatcac tattgctggc attccacaat ccatcattga gtgtgtcaaa cagatctgcg      840

tggtcatgtt ggagactctc tcccagtccc ccccgaaggg cgtgaccatc ccgtaccggc      900

ccaagccgtc cagctctccg gtcatctttg caggtggtca ggacaggtac agcacaggca      960

gcgacagtgc gagctttccc cacaccaccc cgtccatgtg cctcaaccct gacctggagg     1020

gaccacctct agaggcctat accattcaag gacagtatgc cattccacag ccagatttga     1080

ccaagctgca ccagttggca atgcaacagt ctcattttcc catgacgcat ggcaacaccg     1140

gattcagtgg cattgaatcc agctctccag aggtgaaagg ctattgggca ggtttggatg     1200

catctgctca gactacttct catgaactca ccattccaaa cgatttgatt ggctgcataa     1260

tcgggcgtca aggcgccaaa atcaatgaga tccgtcagat gtctggggcg cagatcaaaa     1320

ttgcgaaccc agtggaagga tctactgata ggcaggttac catcactgga tctgctgcca     1380

gcattagcct ggctcaatat ctaatcaatg tcaggctttc ctcggagacg ggtggcatgg     1440

ggagcagcta gaacaatgca gattcatcca taatcccttt ctgctgttca ccaccaccca     1500

tgatccatct gtgtagtttc tgaacagtca gcgattccag gttttaaata gtttgtaaat     1560

tttcagtttc tacacacttt atcatccact cgtgattttt taattaaagc gttttaattc     1620

ctttctctgt tcagctgttg atgctgagat ccatatttag ttttataagc ttctccctgg     1680

tttttttttt ttggctcatg aatttttctg tttgtcatgg aaatgtaaga gtggaatatt     1740

aatacatttc agtttagttc tgtaatgtca ggaatttttc aaaaaaatta aaagatggac     1800

tggagctttt tctttgtgaa tagaaactgg atgccacagt gattcatgtg ggttttattc     1860

ctcttgtctt gctgttattt ttgtaccttt tatccctcaa aggacccttc ttgggttttg     1920

aatggaagcc tttattccgg ttaagatgtt ttcttctatt ttaccacttc catctttttt     1980

tgtggccctc gatcctattt ttccctgact ccatgcttgg ttggccctta taaaacttgt     2040

gcccaaaaga ttgaggatta gactttccga ggacttacct gtcctagggg agtaggcaag     2100

cacttccact agggaggggg tgggggaaag gaatgacaca tgacatacat ggcatacaca     2160

ttaagcagtt gatcatatgt ctgactgggt tccagtttct tgggaatgtt ggtccccttg     2220

ttcaggcttg catattttaa actaaaaatt tcagtctatt gtttttagta acttcattta     2280

tagtcctcca taacaagtta gaaggatgta tctgctacca tttattccta taattttaga     2340

aagttggggc ttgacattat actcatttag tgagagtaga tgcaaaaaag tggaggggca     2400

ggagaacttc tccagacacc tcagataaag tccggagccc aaggctttat cttaaccatg     2460

tatggtaccc cattcattca tcaagaaaac cctcaacagc tgggcctgca tggagtgtta     2520

tatttcaagg tttttcacag gggttacagt aggacagtcc ccaccccaat caggcaccag     2580

gataaaagca gggacttaaa cagcaccccg gttcttcagc ctgagccatc acatgctatc     2640

agtctcctaa cctccccctg ggccttaaga cagggcttgg gcagagaaga taaatggtgg     2700

gacaaaaaaa tgagttacat tgccacctga gaaacctcag aggggaggac ccagccttag     2760

cctccctcct cccaagtgca aaatgtgtaa acagagtaaa cggaacagaa aagtgcagtc     2820

taagtggttt tctctcctgc ccctcccacc gcccctcccc ccacccccta ttatttgggg     2880

ataaagaata taaagacaac cctggctttt ctattgcctt gttgcttgct gaatataagg     2940

aatggggtgg ggcaggaagg ggcttgccct tagccacagc tctacggctg tgcctcattc     3000

atttccacag ctgccagtgt ccctagagtt tatcaggtga attggtcagg ggatcagtct     3060

ccctcgagcc tgacttacgg ctgggacagc cccatctttc tgttgattat gtggcgcata     3120

tatatatata tatgtatata tatataattt atataaatat ttctctatgt aaaaaaaaaa     3180

aaaaaaa                                                               3187


<210> 252
<211> 366
<212> PRT
<213> Homo sapiens

<400> 252
Met Asp Thr Gly Val Ile Glu Gly Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Ala Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Ser Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Val Val Met Leu Glu Thr Leu Ser Gln Ser Pro Pro Lys 
                165                 170                 175     


Gly Val Thr Ile Pro Tyr Arg Pro Lys Pro Ser Ser Ser Pro Val Ile 
            180                 185                 190         


Phe Ala Gly Gly Gln Asp Arg Tyr Ser Thr Gly Ser Asp Ser Ala Ser 
        195                 200                 205             


Phe Pro His Thr Thr Pro Ser Met Cys Leu Asn Pro Asp Leu Glu Gly 
    210                 215                 220                 


Pro Pro Leu Glu Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro Gln 
225                 230                 235                 240 


Pro Asp Leu Thr Lys Leu His Gln Leu Ala Met Gln Gln Ser His Phe 
                245                 250                 255     


Pro Met Thr His Gly Asn Thr Gly Phe Ser Gly Ile Glu Ser Ser Ser 
            260                 265                 270         


Pro Glu Val Lys Gly Tyr Trp Ala Gly Leu Asp Ala Ser Ala Gln Thr 
        275                 280                 285             


Thr Ser His Glu Leu Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile Ile 
    290                 295                 300                 


Gly Arg Gln Gly Ala Lys Ile Asn Glu Ile Arg Gln Met Ser Gly Ala 
305                 310                 315                 320 


Gln Ile Lys Ile Ala Asn Pro Val Glu Gly Ser Thr Asp Arg Gln Val 
                325                 330                 335     


Thr Ile Thr Gly Ser Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu Ile 
            340                 345                 350         


Asn Val Arg Leu Ser Ser Glu Thr Gly Gly Met Gly Ser Ser 
        355                 360                 365     


<210> 253
<211> 1709
<212> DNA
<213> Homo sapiens

<400> 253
agaacactgg cggccgatcc caacgaggct ccctggagcc cgacgcagag cagcgccctg       60

gccgggccaa gcaggagccg gcatcatgga ttccttcaaa gtagtgctgg aggggccagc      120

accttggggc ttccggctgc aagggggcaa ggacttcaat gtgcccctct ccatttcccg      180

gctcactcct gggggcaaag cggcgcaggc cggagtggcc gtgggtgact gggtgctgag      240

catcgatggc gagaatgcgg gtagcctcac acacatcgaa gctcagaaca agatccgggc      300

ctgcggggag cgcctcagcc tgggcctcag cagggcccag ccggttcaga gcaaaccgca      360

gaaggcctcc gcccccgccg cggaccctcc gcggtacacc tttgcaccca gcgtctccct      420

caacaagacg gcccggccct ttggggcgcc cccgcccgct gacagcgccc cgcagcagaa      480

tggacagccg ctccgaccgc tggtcccaga tgccagcaag cagcggctga tggagaacac      540

agaggactgg cggccgcggc cggggacagg ccagtcgcgt tccttccgca tccttgccca      600

cctcacaggc accgagttca tgcaagaccc ggatgaggag cacctgaaga aatcaagcca      660

ggtgcccagg acagaagccc cagccccagc ctcatctaca ccccaggagc cctggcctgg      720

ccctaccgcc cccagcccta ccagccgccc gccctgggct gtggaccctg cgtttgccga      780

gcgctatgcc ccggacaaaa cgagcacagt gctgacccgg cacagccagc cggccacgcc      840

cacgccgctg cagagccgca cctccattgt gcaggcagct gccggagggg tgccaggagg      900

gggcagcaac aacggcaaga ctcccgtgtg tcaccagtgc cacaaggtca tccggggccg      960

ctacctggtg gcgctgggcc acgcgtacca cccggaggag tttgtgtgta gccagtgtgg     1020

gaaggtcctg gaagagggtg gcttctttga ggagaagggc gccatcttct gcccaccatg     1080

ctatgacgtg cgctatgcac ccagctgtgc caagtgcaag aagaagatta caggcgagat     1140

catgcacgcc ctgaagatga cctggcacgt gcactgcttt acctgtgctg cctgcaagac     1200

gcccatccgg aacagggcct tctacatgga ggagggcgtg ccctattgcg agcgagacta     1260

tgagaagatg tttggcacga aatgccatgg ctgtgacttc aagatcgacg ctggggaccg     1320

cttcctggag gccctgggct tcagctggca tgacacctgc ttcgtctgtg cgatatgtca     1380

gatcaacctg gaaggaaaga ccttctactc caagaaggac aggcctctct gcaagagcca     1440

tgccttctct catgtgtgag ccccttctgc ccacagctgc cgcggtggcc cctagcctga     1500

ggggcctgga gtcgtggccc tgcatttctg ggtagggctg gcaatggttg ccttaaccct     1560

ggctcctggc ccgagcctgg ggctccctgg gccctgcccc acccacctta tcctcccacc     1620

ccactccctc caccaccaca gcacaccggt gctggccaca ccagccccct ttcacctcca     1680

gtgccacaat aaacctgtac ccagctgtg                                       1709


<210> 254
<211> 457
<212> PRT
<213> Homo sapiens

<400> 254
Met Asp Ser Phe Lys Val Val Leu Glu Gly Pro Ala Pro Trp Gly Phe 
1               5                   10                  15      


Arg Leu Gln Gly Gly Lys Asp Phe Asn Val Pro Leu Ser Ile Ser Arg 
            20                  25                  30          


Leu Thr Pro Gly Gly Lys Ala Ala Gln Ala Gly Val Ala Val Gly Asp 
        35                  40                  45              


Trp Val Leu Ser Ile Asp Gly Glu Asn Ala Gly Ser Leu Thr His Ile 
    50                  55                  60                  


Glu Ala Gln Asn Lys Ile Arg Ala Cys Gly Glu Arg Leu Ser Leu Gly 
65                  70                  75                  80  


Leu Ser Arg Ala Gln Pro Val Gln Ser Lys Pro Gln Lys Ala Ser Ala 
                85                  90                  95      


Pro Ala Ala Asp Pro Pro Arg Tyr Thr Phe Ala Pro Ser Val Ser Leu 
            100                 105                 110         


Asn Lys Thr Ala Arg Pro Phe Gly Ala Pro Pro Pro Ala Asp Ser Ala 
        115                 120                 125             


Pro Gln Gln Asn Gly Gln Pro Leu Arg Pro Leu Val Pro Asp Ala Ser 
    130                 135                 140                 


Lys Gln Arg Leu Met Glu Asn Thr Glu Asp Trp Arg Pro Arg Pro Gly 
145                 150                 155                 160 


Thr Gly Gln Ser Arg Ser Phe Arg Ile Leu Ala His Leu Thr Gly Thr 
                165                 170                 175     


Glu Phe Met Gln Asp Pro Asp Glu Glu His Leu Lys Lys Ser Ser Gln 
            180                 185                 190         


Val Pro Arg Thr Glu Ala Pro Ala Pro Ala Ser Ser Thr Pro Gln Glu 
        195                 200                 205             


Pro Trp Pro Gly Pro Thr Ala Pro Ser Pro Thr Ser Arg Pro Pro Trp 
    210                 215                 220                 


Ala Val Asp Pro Ala Phe Ala Glu Arg Tyr Ala Pro Asp Lys Thr Ser 
225                 230                 235                 240 


Thr Val Leu Thr Arg His Ser Gln Pro Ala Thr Pro Thr Pro Leu Gln 
                245                 250                 255     


Ser Arg Thr Ser Ile Val Gln Ala Ala Ala Gly Gly Val Pro Gly Gly 
            260                 265                 270         


Gly Ser Asn Asn Gly Lys Thr Pro Val Cys His Gln Cys His Lys Val 
        275                 280                 285             


Ile Arg Gly Arg Tyr Leu Val Ala Leu Gly His Ala Tyr His Pro Glu 
    290                 295                 300                 


Glu Phe Val Cys Ser Gln Cys Gly Lys Val Leu Glu Glu Gly Gly Phe 
305                 310                 315                 320 


Phe Glu Glu Lys Gly Ala Ile Phe Cys Pro Pro Cys Tyr Asp Val Arg 
                325                 330                 335     


Tyr Ala Pro Ser Cys Ala Lys Cys Lys Lys Lys Ile Thr Gly Glu Ile 
            340                 345                 350         


Met His Ala Leu Lys Met Thr Trp His Val His Cys Phe Thr Cys Ala 
        355                 360                 365             


Ala Cys Lys Thr Pro Ile Arg Asn Arg Ala Phe Tyr Met Glu Glu Gly 
    370                 375                 380                 


Val Pro Tyr Cys Glu Arg Asp Tyr Glu Lys Met Phe Gly Thr Lys Cys 
385                 390                 395                 400 


His Gly Cys Asp Phe Lys Ile Asp Ala Gly Asp Arg Phe Leu Glu Ala 
                405                 410                 415     


Leu Gly Phe Ser Trp His Asp Thr Cys Phe Val Cys Ala Ile Cys Gln 
            420                 425                 430         


Ile Asn Leu Glu Gly Lys Thr Phe Tyr Ser Lys Lys Asp Arg Pro Leu 
        435                 440                 445             


Cys Lys Ser His Ala Phe Ser His Val 
    450                 455         


<210> 255
<211> 1151
<212> DNA
<213> Homo sapiens

<400> 255
gataatgcca ggccctgccc ccggcagagg cggaagcgga gtcggcctga gaggtctctc       60

gtcgctgcag gcgcctcagc ccagccgcgt gccttggccc atggccgcct actcttaccg      120

ccccggccct ggggccggcc ctgggcctgc tgcaggcgcg gcgctgccgg accagagctt      180

cctgtggaac gttttccaga gggtcgataa agacaggagt ggagtgatat cagacaccga      240

gcttcagcaa gctctctcca acggcacgtg gactcccttt aatccagtga ctgtcaggtc      300

gatcatatcc atgtttgacc gtgagaacaa ggccggcgtg aacttcagcg agttcacggg      360

tgtgtggaag tacatcacgg actggcagaa cgtcttccgc acgtacgacc gggacaactc      420

cgggatgatc gataagaacg agctgaagca ggccctctca ggtttcggct accggctctc      480

tgaccagttc cacgacatcc tcattcgaaa gtttgacagg cagggacggg ggcagattgc      540

cttcgacgac ttcatccagg gctgcatcgt cctgcagagg ttgacggata tattcagacg      600

ttacgacacg gatcaggacg gctggattca ggtgtcgtac gaacagtacc tgtccatggt      660

cttcagtatc gtatgaccct ggcctctcgt gaagagcagc acaacatgga aagagccaaa      720

atgtcacagt tcctatctgt gagggaatgg agcacaggtg cagttagatg ctgttcttcc      780

tttagatttt gtcacgtggg gacccagctg tacatatgtg gataagctga ttaatggttt      840

tgcaactgta atagtagctg tatcgttcta atgcagacat tggatttggt gactgtctca      900

ttgtgccatg aggtaaatgt aatgtttcag gcattctgct tgcaaaaaaa tctatcatgt      960

gcttttctag atgtctctgg ttctatagtg caaatgcttt tattagccaa taggaatttt     1020

aaaataacat ggaacttaca caaaaggctt ttcatgtgcc ttactttttt aaaaaggagt     1080

ttattgtatt cattggaata tgtgacgtaa gcaataaagg gaatgttaga cgtgtaaaaa     1140

aaaaaaaaaa a                                                          1151


<210> 256
<211> 191
<212> PRT
<213> Homo sapiens

<400> 256
Met Ala Ala Tyr Ser Tyr Arg Pro Gly Pro Gly Ala Gly Pro Gly Pro 
1               5                   10                  15      


Ala Ala Gly Ala Ala Leu Pro Asp Gln Ser Phe Leu Trp Asn Val Phe 
            20                  25                  30          


Gln Arg Val Asp Lys Asp Arg Ser Gly Val Ile Ser Asp Thr Glu Leu 
        35                  40                  45              


Gln Gln Ala Leu Ser Asn Gly Thr Trp Thr Pro Phe Asn Pro Val Thr 
    50                  55                  60                  


Val Arg Ser Ile Ile Ser Met Phe Asp Arg Glu Asn Lys Ala Gly Val 
65                  70                  75                  80  


Asn Phe Ser Glu Phe Thr Gly Val Trp Lys Tyr Ile Thr Asp Trp Gln 
                85                  90                  95      


Asn Val Phe Arg Thr Tyr Asp Arg Asp Asn Ser Gly Met Ile Asp Lys 
            100                 105                 110         


Asn Glu Leu Lys Gln Ala Leu Ser Gly Phe Gly Tyr Arg Leu Ser Asp 
        115                 120                 125             


Gln Phe His Asp Ile Leu Ile Arg Lys Phe Asp Arg Gln Gly Arg Gly 
    130                 135                 140                 


Gln Ile Ala Phe Asp Asp Phe Ile Gln Gly Cys Ile Val Leu Gln Arg 
145                 150                 155                 160 


Leu Thr Asp Ile Phe Arg Arg Tyr Asp Thr Asp Gln Asp Gly Trp Ile 
                165                 170                 175     


Gln Val Ser Tyr Glu Gln Tyr Leu Ser Met Val Phe Ser Ile Val 
            180                 185                 190     


<210> 257
<211> 3944
<212> DNA
<213> Homo sapiens

<400> 257
gagctcaccg ctgccagtcg cgctgcctgc ccgtcccacc cttttcgtgc aggcattcag       60

ctaaatgacg ggcggagccc ggcggcggct tccggtcggg ggaaaaaagt tgggccgaag      120

gaggggccgg gaagacgcaa gaggaagaag agaaaacggc cgggcggcgg tggctgtagg      180

ttgtgcggct gcagcggctc ttccctgggc ggacgatgga cagccagggc aggaaggtgg      240

tggtgtgcga caacggcacc gggtttgtga agtgtggata tgcaggctct aactttccag      300

aacacatctt cccagctttg gttggaagac ctattatcag atcaaccacc aaagtgggaa      360

acattgaaat caagaataac aaaaagatgg atcttatggt tggtgatgag gcaagtgaat      420

tacgatcaat gttagaagtt aactacccta tggaaaatgg catagtacga aattgggatg      480

acatgaaaca cctgtgggac tacacatttg gaccagagaa acttaatata gataccagaa      540

attgtaaaat cttactcaca gaacctccta tgaacccaac caaaaacaga gagaagattg      600

tagaggtaat gtttgaaact taccagtttt ccggtgtata tgtagccatc caggcagttc      660

tgactttgta cgctcaaggt ttattgactg gtgtagtggt agactctgga gatggtgtga      720

ctcacatttg cccagtatat gaaggctttt ctctccctca tcttaccagg agactggata      780

ttgctgggag ggatataact agatatctta tcaagctact tctgttgcga ggatacgcct      840

tcaaccactc tgctgatttt gaaacggttc gcatgattaa agaaaaactg tgttacgtgg      900

gatataatat tgagcaagag cagaaactgg ccttagaaac cacagtatta gttgaatctt      960

atacactccc agatggacgt atcatcaaag ttgggggaga gagatttgaa gcaccagaag     1020

ctttatttca gcctcacttg atcaatgttg aaggagttgg tgttgctgaa ttgcttttta     1080

acacaattca ggcagctgac attgatacca gatctgaatt ctacaaacac attgtgcttt     1140

ctggagggtc tactatgtat cctggcctgc catcacggtt ggaacgagaa cttaaacagc     1200

tttacttaga acgagttttg aagggtgatg tggaaaaact ttctaaattt aagatccgca     1260

ttgaagaccc accccgcaga aagcacatgg tattcctggg tggtgcagtt ctagcggata     1320

tcatgaaaga caaagacaac ttttggatga cccgacaaga gtaccaagaa aagggtgtcc     1380

gtgtgctaga gaaacttggt gtgactgttc gataaactcc aaagcttgtt cccgtcatac     1440

ccgtaatgct ttcttttttc ctttattgcc aatctttgaa ctcattcaac tccaggacat     1500

ggaagaggcc tctctctgcc ctttgactgg aaaggtcaag ttttattctg gtgtcttggg     1560

gaagctttgt taaatttttg ttaatgtggg taaatctgag tttaattcaa ctgcttccct     1620

acatagacta gagggctaag gattctgtct gctgctttgt ttcttctaag taggcattta     1680

gatcattcct ataggcttcc tattttcact ttactgctct aatgctgcta gtcgtagtct     1740

ttagcacact aggtggtatg cctttattag cataaaacaa aaaaaacttt aacaggagct     1800

tttacatatt actgggatgg ggggtggttc gggatgggtg ggcagctgct gaacccttta     1860

gggcatttcc tctgtaatgt ggcgctttca actgtactgc tgcagcttta agtaccttaa     1920

agcttctcct gtgaacttct tagggaaatg ttaggttcag aactaaagtg ttttgggtgg     1980

gttttgttgc gggggggagg gtaacaatgg gtggtcttct gatttttatt tttgaggttt     2040

tgtcaactgg agtacgtaga ggaactttat ttacagtact ttgatttggc aggttttctt     2100

ctacttgtgc tctgcctgga gctgtttcca tatgatataa aaagcaagtg tagtattcca     2160

ttactatgtg gcttagggat ttatttgttt tttaaaatca accatgttag ctgggattag     2220

actccctaca gtccttcaat ggaaaagtaa catttaaaaa tcctttgggt aattcgaatt     2280

acagatttaa aagagcttaa gatctggtgt tttgttaatg cttctgttta ttccagaagc     2340

attaaggtaa cccattgcca agtatcattc ttgcaaatta ttcttttata taactgacca     2400

gtgcttaata aaacaagcag gtacttacaa ataattactg gcagtaggtt ataattggtg     2460

gtttaaaaat aacattggaa tacaggactt gttgccaatt gggtaatttt cattagttgt     2520

tttgtttgtt ttgatttgaa acctggaaat acagtaaaat ttgactgttt aaaatgttgg     2580

ccaaaaaaat caagatttaa tttttttatt tgtactgaaa aactaatcat aactgttaat     2640

tctcagccat ctttgaagct tgaaagaaga gtctttggta ttttgtaaac gttagcagac     2700

tttcctgcca gtgtcagaaa atcctattta tgaatcctgt cggtattcct tggtatctga     2760

aaaaaatacc aaatagtacc atacatgagt tatttctaag tttgaaaaat aaaaagaaat     2820

tgcatcacac taattacaaa atacaagttc tggaaaaaat atttttcttc attttaaaac     2880

ttttttttaa ctaataatag ctttgaaaga agaggcttaa tttgggggtg gtaactaaaa     2940

tcaaaagaaa tgattgactt gagggtctct gtttggtaag aatacatcat tagcttaaat     3000

aagcagcaga aggttagttt taattatgta gcttctgtta atattaagtg ttttttgtct     3060

gttttacctc aatttgaaca gataagtttg cctgcatgct ggacatgcct cagaaccctg     3120

aatagcccgt actagatctt gggaacatgg atcttagagt cactttggaa taagttctta     3180

tataaatacc cccagccttt tgagaacggg gcttgttaaa ggacgcgtat gtagggcccg     3240

tacctactgg cagttgggtt cagggaaatg ggattgactt ggccttcagg ctcctttggt     3300

cataatttta aaatatggga gtagaaaaca acaaagaatg gaatggactc ttaaaacaat     3360

gaaagagcat ttatcgtttg tcccttgaat gtagaatttg tttttgattt cataattctg     3420

ctggtaaatg tgacagttaa aatggtgcat tatgtatata tattataatt tagaaatacc     3480

attttataat tttactattc cagggtgaca taatgcattt aaatttggga tttgggtgga     3540

gtattatgtt taactggagt tgtcaagtat gagtccctca ggaaaaaaaa aaaattctgt     3600

tttaaaaagc aatctgattc ttagctcttg aaactattgc tacttaaatt tccaataatt     3660

aaaaatttaa aatttttaaa ttagaattgc caatacttct acatttgaga agggtttttt     3720

tagaaataca tttagtaaag tccccaagac attagtctta catttaaact tttttcttta     3780

aaacatggtt ttggtggtta acttttacac agttctgagt actgttaata tctggaaagt     3840

atcttgagat atcagtggaa agctaaacag tctaaattaa catgaaatac ttcattttga     3900

ttgagaaaat aaaatcagat tttttcaaag tcaaaaaaaa aaaa                      3944


<210> 258
<211> 399
<212> PRT
<213> Homo sapiens

<400> 258
Met Asp Ser Gln Gly Arg Lys Val Val Val Cys Asp Asn Gly Thr Gly 
1               5                   10                  15      


Phe Val Lys Cys Gly Tyr Ala Gly Ser Asn Phe Pro Glu His Ile Phe 
            20                  25                  30          


Pro Ala Leu Val Gly Arg Pro Ile Ile Arg Ser Thr Thr Lys Val Gly 
        35                  40                  45              


Asn Ile Glu Ile Lys Asn Asn Lys Lys Met Asp Leu Met Val Gly Asp 
    50                  55                  60                  


Glu Ala Ser Glu Leu Arg Ser Met Leu Glu Val Asn Tyr Pro Met Glu 
65                  70                  75                  80  


Asn Gly Ile Val Arg Asn Trp Asp Asp Met Lys His Leu Trp Asp Tyr 
                85                  90                  95      


Thr Phe Gly Pro Glu Lys Leu Asn Ile Asp Thr Arg Asn Cys Lys Ile 
            100                 105                 110         


Leu Leu Thr Glu Pro Pro Met Asn Pro Thr Lys Asn Arg Glu Lys Ile 
        115                 120                 125             


Val Glu Val Met Phe Glu Thr Tyr Gln Phe Ser Gly Val Tyr Val Ala 
    130                 135                 140                 


Ile Gln Ala Val Leu Thr Leu Tyr Ala Gln Gly Leu Leu Thr Gly Val 
145                 150                 155                 160 


Val Val Asp Ser Gly Asp Gly Val Thr His Ile Cys Pro Val Tyr Glu 
                165                 170                 175     


Gly Phe Ser Leu Pro His Leu Thr Arg Arg Leu Asp Ile Ala Gly Arg 
            180                 185                 190         


Asp Ile Thr Arg Tyr Leu Ile Lys Leu Leu Leu Leu Arg Gly Tyr Ala 
        195                 200                 205             


Phe Asn His Ser Ala Asp Phe Glu Thr Val Arg Met Ile Lys Glu Lys 
    210                 215                 220                 


Leu Cys Tyr Val Gly Tyr Asn Ile Glu Gln Glu Gln Lys Leu Ala Leu 
225                 230                 235                 240 


Glu Thr Thr Val Leu Val Glu Ser Tyr Thr Leu Pro Asp Gly Arg Ile 
                245                 250                 255     


Ile Lys Val Gly Gly Glu Arg Phe Glu Ala Pro Glu Ala Leu Phe Gln 
            260                 265                 270         


Pro His Leu Ile Asn Val Glu Gly Val Gly Val Ala Glu Leu Leu Phe 
        275                 280                 285             


Asn Thr Ile Gln Ala Ala Asp Ile Asp Thr Arg Ser Glu Phe Tyr Lys 
    290                 295                 300                 


His Ile Val Leu Ser Gly Gly Ser Thr Met Tyr Pro Gly Leu Pro Ser 
305                 310                 315                 320 


Arg Leu Glu Arg Glu Leu Lys Gln Leu Tyr Leu Glu Arg Val Leu Lys 
                325                 330                 335     


Gly Asp Val Glu Lys Leu Ser Lys Phe Lys Ile Arg Ile Glu Asp Pro 
            340                 345                 350         


Pro Arg Arg Lys His Met Val Phe Leu Gly Gly Ala Val Leu Ala Asp 
        355                 360                 365             


Ile Met Lys Asp Lys Asp Asn Phe Trp Met Thr Arg Gln Glu Tyr Gln 
    370                 375                 380                 


Glu Lys Gly Val Arg Val Leu Glu Lys Leu Gly Val Thr Val Arg 
385                 390                 395                 


<210> 259
<211> 2412
<212> DNA
<213> Homo sapiens

<400> 259
agtgctagtg gcggcaggtg caggtggccg cgcggcatcc tggggcttgc agtctcccga       60

gcgttctgtt gtgtccctgc ctacaatttt agggaaccta ataaaagggt ggtcggtatg      120

tttttatttg ggtgtgtact tttgttaggt cgctttttcg ctatgcatta agtacggact      180

ttaggactca actagtacca ggaagaaaaa gaccggacat tttcacctgt ttgttataca      240

gcgaagggga aaaattggga agaaatcctc aagctacaag aaaaataacc agaagcttta      300

cactttagcc tgcagtgact tatatcctgg tgtcctaagt ccacctaagt cagttttgca      360

ataagaggtc ccaagtttgg ttttcttgga gcttgcatca gttggttgca tcatccctga      420

gtagaagatt tgcggttgca aggaaaaata aggtacagag cttctccagc gggaaagtgc      480

atgtctgcac ggcacgagcc cacgcaccgc agaacaggct tgccaggtct cctcagagac      540

cctcgcagga acctaacaat gaaatccagt tgtccagtct tgatttgtgg aggggtaagg      600

agaatccgag gccagtgggc aatccgccca ctgttgggag cgactgacct cacgaatcaa      660

taatttgctt ttgactagga agtgcagcgg ttcttggggg gaggggctgg actgggtggc      720

ggacgcgagg agcaacggtt ctcccgaacc tctcccccgc ccctactatc ttggcctaca      780

ttttcccgct ccgtcccggg acctggacac ccagaatcca cgaaaagcaa ctcgcgctcg      840

agaacagctc tcgtaccctt ctacgtgatc tgcaccttta agctcactcc atcccaaacc      900

ggaccccgga ggcaccaccc acatccgtct aacatcactt ccttcagagt ttgaaaaaaa      960

aaaatctggg aagtagaggt gttgtgctga gcggcgctcg gcgaactgtg tggaccgtct     1020

gctgggactc cggccctgcg tccgctcagc cccgtggccc cgcgcaccta ctgccatgga     1080

gacgcggcct cgtctcgggg ccacctgttt gctgggcttc agtttcctgc tcctcgtcat     1140

ctcttctgat ggacataatg ggcttggaaa gggttttgga gatcatattc attggaggac     1200

actggaagat gggaagaaag aagcagctgc cagtggactg cccctgatgg tgattattca     1260

taaatcctgg tgtggagctt gcaaagctct aaagcccaaa tttgcagaat ctacggaaat     1320

ttcagaactc tcccataatt ttgttatggt aaatcttgag gatgaagagg aacccaaaga     1380

tgaagatttc agccctgacg ggggttatat tccacgaatc ctttttctgg atcccagtgg     1440

caaggtgcat cctgaaatca tcaatgagaa tggaaacccc agctacaagt atttttatgt     1500

cagtgccgag caagttgttc aggggatgaa ggaagctcag gaaaggctga cgggtgatgc     1560

cttcagaaag aaacatcttg aagatgaatt gtaacatgaa tgtgcccctt ctttcatcag     1620

agttagtgtt ctggaaggaa agcagcaggg aagggaatat tgaggaatca tctagaacaa     1680

ttaagccgac caggaaacct cattcctacc tacactggaa ggagcgctct cactgtggaa     1740

gagttctgct aacagaagct ggtctgcatg tttgtggatc cagcggagag tggcagactt     1800

tcttctcctt ttccctctca cctaaatgtc aacttgtcat tgaatgtaaa gaatgaaacc     1860

ttctgacaca aaacttgagc cacttggatg tttactcctc gcacttaagt atttgagtct     1920

tttcccattt cctcccactt tactcacctt agtggtgaaa ggagactagt agcatctttt     1980

ctacaacgtt aaaattgcag aagtagctta tcattaaaaa acaacaacaa caacaataac     2040

aataaatcct aagtgtaaat cagttattct accccctacc aaggatatca gcctgttttt     2100

tccctttttt ctcctgggaa taattgtggg cttcttccca aatttctaca gcctctttcc     2160

tcttctcatg cttgagcttc cctgtttgca cgcatgcgtg tgcaggactg gctgtgtgct     2220

tggactcggc tccaggtgga agcatgcttt cccttgttac tgttggagaa actcaaacct     2280

tcaagcccta ggtgtagcca ttttgtcaag tcatcaactg tatttttgta ctggcattaa     2340

caaaaaaaga gataaaatat tgtaccatta aactttaata aaactttaaa aggaaaaaaa     2400

aaaaaaaaaa aa                                                         2412


<210> 260
<211> 172
<212> PRT
<213> Homo sapiens

<400> 260
Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu Leu Gly Phe Ser 
1               5                   10                  15      


Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn Gly Leu Gly Lys 
            20                  25                  30          


Gly Phe Gly Asp His Ile His Trp Arg Thr Leu Glu Asp Gly Lys Lys 
        35                  40                  45              


Glu Ala Ala Ala Ser Gly Leu Pro Leu Met Val Ile Ile His Lys Ser 
    50                  55                  60                  


Trp Cys Gly Ala Cys Lys Ala Leu Lys Pro Lys Phe Ala Glu Ser Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Leu Ser His Asn Phe Val Met Val Asn Leu Glu Asp 
                85                  90                  95      


Glu Glu Glu Pro Lys Asp Glu Asp Phe Ser Pro Asp Gly Gly Tyr Ile 
            100                 105                 110         


Pro Arg Ile Leu Phe Leu Asp Pro Ser Gly Lys Val His Pro Glu Ile 
        115                 120                 125             


Ile Asn Glu Asn Gly Asn Pro Ser Tyr Lys Tyr Phe Tyr Val Ser Ala 
    130                 135                 140                 


Glu Gln Val Val Gln Gly Met Lys Glu Ala Gln Glu Arg Leu Thr Gly 
145                 150                 155                 160 


Asp Ala Phe Arg Lys Lys His Leu Glu Asp Glu Leu 
                165                 170         


<210> 261
<211> 2146
<212> DNA
<213> Homo sapiens

<400> 261
ccaccctggg cccgcccccg gctccatctt gcgggagacc gggttgggct gtgacgctgc       60

tgctggggtc agaatgtcat acccaggcta tcccccaaca ggctacccac ctttccctgg      120

atatcctcct gcaggtcagg agtcatcttt tcccccttct ggtcagtatc cttatcctag      180

tggctttcct ccaatgggag gaggtgccta cccacaagtg ccaagtagtg gctacccagg      240

agctggaggc taccctgcgc ctggaggtta tccagcccct ggaggctatc ctggtgcccc      300

acagccaggg ggagctccat cctatcccgg agttcctcca ggccaaggat ttggagtccc      360

accaggtgga gcaggctttt ctgggtatcc acagccacct tcacagtctt atggaggtgg      420

tccagcacag gttccactac ctggtggctt tcctggagga cagatgcctt ctcagtatcc      480

tggaggacaa cctacttacc ctagtcagcc tgccacagtg actcaggtca ctcaaggaac      540

tatccgacca gctgccaact tcgatgctat aagagatgca gaaattcttc gtaaggcaat      600

gaagggtttt gggacagatg agcaggcaat tgtggatgtg gtggccaacc gttccaatga      660

tcagaggcaa aaaattaaag cagcatttaa gacctcctat ggcaaggatt taatcaaaga      720

tctcaaatca gagttaagtg gaaatatgga agaactgatc ctggccctct tcatgcctcc      780

tacgtattac gatgcctgga gcttacggaa agcaatgcag ggagcaggaa ctcaggaacg      840

tgtattgatt gagattttgt gcacaagaac aaatcaggaa atccgagaaa ttgtcagatg      900

ttatcagtca gaatttggac gagaccttga aaaggacatt aggtcagata catcaggaca      960

ttttgaacgt ttacttgtgt ccatgtgcca gggaaatcgt gatgagaacc agagtataaa     1020

ccaccaaatg gctcaggaag atgctcagcg tctctatcaa gctggtgagg ggagactagg     1080

gaccgatgaa tcttgcttta acatgatcct tgccacaaga agctttcctc agctgagagc     1140

taccatggag gcttattcta ggatggctaa tcgagacttg ttaagcagtg tgagccgtga     1200

gttttccgga tatgtagaaa gtggtttgaa gaccatcttg cagtgtgccc tgaaccgccc     1260

tgccttcttt gctgagaggc tctactatgc tatgaaaggt gctggcacag atgactccac     1320

cctggtccgg attgtggtca ctcgaagtga gattgacctt gtacaaataa aacagatgtt     1380

cgctcagatg tatcagaaga ctctgggcac aatgattgca ggtgacacga gtggagatta     1440

ccgaagactt cttctggcta ttgtgggcca gtaggaggga tttttttttt tttaatgaaa     1500

aaaaatttct attcatagct tatccttcag agcaatgacc tgcatgcagc aatatcaaac     1560

atcagctaac cgaaagagct ttctgtcaag gaccgtatca gggtaatgtg cttggtttgc     1620

acatgttgtt attgccttaa ttctaatttt attttgttct ctacatacaa tcaatgtaaa     1680

gccatatcac aatgatacag taatattgca atgtttgtaa accttcattc ttactagttt     1740

cattctaatc aagatgtcaa attgaataaa aatcacagca atctctgatt ctgtgtaata     1800

atattgaata attttttaga aggttactga aagctctgcc ttccggaatc cctctaagtc     1860

tgcttgatag agtggatagt gtgttaaaac tgtgtacttt aaaaaaaaat tcaaccttta     1920

catctagaat aatttgcatc tcattttgcc taaattggtt ctgtattcat aaacactttc     1980

cacatagaaa atagattagt attacctgtg gcacctttta agaaagggtc aaatgtttat     2040

atgcttaaga tacatagcct actttttttt cgcagttgtt ttcttttttt aaattgagtt     2100

atgacaaata aaaaattgca tatatttaag gtgtacaaaa aaaaaa                    2146


<210> 262
<211> 466
<212> PRT
<213> Homo sapiens

<400> 262
Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln 
465     


<210> 263
<211> 3536
<212> DNA
<213> Homo sapiens

<400> 263
gtcccagggg gcggggcaga ggaaaaggcg ccggccccac agtgctcccc gcttccgccc       60

agtccagccc gggccggctg accgggtccg acacagtctc ctggaccagg ctccctccat      120

cctcacccct cccccagctt cccgccgcca ctcaccgaac cggaaccggc tgccatgcga      180

aggggtttcc ggccgggcgc ggaacgcaaa acccgggaac cgccgcgaac cggaaccgcc      240

ttcacagcac cggaagagtc gctaggaggc agccatgcat aaagacgagt ttcatctgaa      300

atttttcatg tgtgtgattc agtctcgcca gttagtcagg actcctcaga gaacagctgg      360

ggaagcttct acttccagca tgctcatacc aaagccacca ccaaagacag acatcttgaa      420

gagtctagat actatggatg atccagacac cgtgggaagc atacctgttt tcaaaactga      480

gtggatcatg acccatgaag agcaccatgc agccaaaacc ctggggattg gcaaagccat      540

tgctgtctta acctctggtg gagatgccca aggtatgaat gctgctgtca gggctgtggt      600

tcgagttggt atcttcaccg gtgcccgtgt cttctttgtc catgagggtt atcaaggcct      660

ggtggatggt ggagatcaca tcaaggaagc cacctgggag agcgtttcga tgatgcttca      720

gctgggaggc acggtgattg gaagtgcccg gtgcaaggac tttcgggaac gagaaggacg      780

actccgagct gcctacaacc tggtgaagcg tgggatcacc aatctctgtg tcattggggg      840

tgatggcagc ctcactgggg ctgacacctt ccgttctgag tggagtgact tgttgagtga      900

cctccagaaa gcaggtaaga tcacagatga ggaggctacg aagtccagct acctgaacat      960

tgtgggcctg gttgggtcaa ttgacaatga cttctgtggc accgatatga ccattggcac     1020

tgactctgcc ctgcatcgga tcatggaaat tgtagatgcc atcactacca ctgcccagag     1080

ccaccagagg acatttgtgt tagaagtaat gggccgccac tgtggatacc tggcccttgt     1140

cacctctctg tcctgtgggg ccgactgggt ttttattcct gaatgtccac cagatgacga     1200

ctgggaggaa cacctttgtc gccgactcag cgagacaagg acccgtggtt ctcgtctcaa     1260

catcatcatt gtggctgagg gtgcaattga caagaatgga aaaccaatca cctcagaaga     1320

catcaagaat ctggtggtta agcgtctggg atatgacacc cgggttactg tcttggggca     1380

tgtgcagagg ggtgggacgc catcagcctt tgacagaatt ctgggcagca ggatgggtgt     1440

ggaagcagtg atggcacttt tggaggggac cccagatacc ccagcctgtg tagtgagcct     1500

ctctggtaac caggctgtgc gcctgcccct catggaatgt gtccaggtga ccaaagatgt     1560

gaccaaggcc atggatgaga agaaatttga cgaagccctg aagctgagag gccggagctt     1620

catgaacaac tgggaggtgt acaagcttct agctcatgtc agacccccgg tatctaagag     1680

tggttcgcac acagtggctg tgatgaacgt gggggctccg gctgcaggca tgaatgctgc     1740

tgttcgctcc actgtgagga ttggccttat ccagggcaac cgagtgctcg ttgtccatga     1800

tggtttcgag ggcctggcca aggggcagat agaggaagct ggctggagct atgttggggg     1860

ctggactggc caaggtggct ctaaacttgg gactaaaagg actctaccca agaagagctt     1920

tgaacagatc agtgccaata taactaagtt taacattcag ggccttgtca tcattggggg     1980

ctttgaggct tacacagggg gcctggaact gatggagggc aggaagcagt ttgatgagct     2040

ctgcatccca tttgtggtca ttcctgctac agtctccaac aatgtccctg gctcagactt     2100

cagcgttggg gctgacacag cactcaatac tatctgcaca acctgtgacc gcatcaagca     2160

gtcagcagct ggcaccaagc gtcgggtgtt tatcattgag actatgggtg gctactgtgg     2220

ctacctggct accatggctg gactggcagc tggggccgat gctgcctaca tttttgagga     2280

gcccttcacc attcgagacc tgcaggcaaa tgttgaacat ctggtgcaaa agatgaaaac     2340

aactgtgaaa aggggcttgg tgttaaggaa tgaaaagtgc aatgagaact ataccactga     2400

cttcattttc aacctgtact ctgaggaggg gaagggcatc ttcgacagca ggaagaatgt     2460

gcttggtcac atgcagcagg gtgggagccc aaccccattt gataggaatt ttgccactaa     2520

gatgggcgcc aaggctatga actggatgtc tgggaaaatc aaagagagtt accgtaatgg     2580

gcggatcttt gccaatactc cagattcggg ctgtgttctg gggatgcgta agagggctct     2640

ggtcttccaa ccagtggctg agctgaagga ccagacagat tttgagcatc gaatccccaa     2700

ggaacagtgg tggctgaaac tgaggcccat cctcaaaatc ctagccaagt acgagattga     2760

cttggacact tcagaccatg cccacctgga gcacatcacc cggaagcggt ccggggaagc     2820

tgccgtctaa acctctctgg agtgagggga atagattacc tgatcatggt cagctcacac     2880

cctaataagt ccacatcttc tcagtgtttt agctgttttt ttcattaggt ttccttttat     2940

tctgtacctt gcagccatga ccagttctgg ccaggagctg gaggagcagg cagtgggtgg     3000

gagctccttt taggtagaat ttaacatgac ttctgcccca gctttatctg tcacacaagg     3060

ctgggcacct ctagtgctac tgctagatat cacttactca gttagaattt tcctaaaaat     3120

aagctttatt tatttctttg tgataacaaa gagtcttggt tcctctacta cttttactac     3180

agtgacaaat tgtaactaca ctaataaatg ccaactggtc actgtgcttt tgcttctcct     3240

gttatcatct tcctaagtgg aatgtaatac tgtcagcccc atgtatcaga cacttgtctg     3300

atgaagcagt aaagacgtta agggtatcac agggggtgga ggaagggatt atctctagta     3360

cactacttgc tggctgtctg aaaaattgtc actgccaaac tctaaaaaca gttctaaata     3420

gtgactgaga aggtttgttg ctggagtcag ggaataaggc agccaaatac tctttgcaca     3480

gttctttagt gggaagagaa attaacaata aatatcaagc actgtgaaaa aaaaaa         3536


<210> 264
<211> 851
<212> PRT
<213> Homo sapiens

<400> 264
Met His Lys Asp Glu Phe His Leu Lys Phe Phe Met Cys Val Ile Gln 
1               5                   10                  15      


Ser Arg Gln Leu Val Arg Thr Pro Gln Arg Thr Ala Gly Glu Ala Ser 
            20                  25                  30          


Thr Ser Ser Met Leu Ile Pro Lys Pro Pro Pro Lys Thr Asp Ile Leu 
        35                  40                  45              


Lys Ser Leu Asp Thr Met Asp Asp Pro Asp Thr Val Gly Ser Ile Pro 
    50                  55                  60                  


Val Phe Lys Thr Glu Trp Ile Met Thr His Glu Glu His His Ala Ala 
65                  70                  75                  80  


Lys Thr Leu Gly Ile Gly Lys Ala Ile Ala Val Leu Thr Ser Gly Gly 
                85                  90                  95      


Asp Ala Gln Gly Met Asn Ala Ala Val Arg Ala Val Val Arg Val Gly 
            100                 105                 110         


Ile Phe Thr Gly Ala Arg Val Phe Phe Val His Glu Gly Tyr Gln Gly 
        115                 120                 125             


Leu Val Asp Gly Gly Asp His Ile Lys Glu Ala Thr Trp Glu Ser Val 
    130                 135                 140                 


Ser Met Met Leu Gln Leu Gly Gly Thr Val Ile Gly Ser Ala Arg Cys 
145                 150                 155                 160 


Lys Asp Phe Arg Glu Arg Glu Gly Arg Leu Arg Ala Ala Tyr Asn Leu 
                165                 170                 175     


Val Lys Arg Gly Ile Thr Asn Leu Cys Val Ile Gly Gly Asp Gly Ser 
            180                 185                 190         


Leu Thr Gly Ala Asp Thr Phe Arg Ser Glu Trp Ser Asp Leu Leu Ser 
        195                 200                 205             


Asp Leu Gln Lys Ala Gly Lys Ile Thr Asp Glu Glu Ala Thr Lys Ser 
    210                 215                 220                 


Ser Tyr Leu Asn Ile Val Gly Leu Val Gly Ser Ile Asp Asn Asp Phe 
225                 230                 235                 240 


Cys Gly Thr Asp Met Thr Ile Gly Thr Asp Ser Ala Leu His Arg Ile 
                245                 250                 255     


Met Glu Ile Val Asp Ala Ile Thr Thr Thr Ala Gln Ser His Gln Arg 
            260                 265                 270         


Thr Phe Val Leu Glu Val Met Gly Arg His Cys Gly Tyr Leu Ala Leu 
        275                 280                 285             


Val Thr Ser Leu Ser Cys Gly Ala Asp Trp Val Phe Ile Pro Glu Cys 
    290                 295                 300                 


Pro Pro Asp Asp Asp Trp Glu Glu His Leu Cys Arg Arg Leu Ser Glu 
305                 310                 315                 320 


Thr Arg Thr Arg Gly Ser Arg Leu Asn Ile Ile Ile Val Ala Glu Gly 
                325                 330                 335     


Ala Ile Asp Lys Asn Gly Lys Pro Ile Thr Ser Glu Asp Ile Lys Asn 
            340                 345                 350         


Leu Val Val Lys Arg Leu Gly Tyr Asp Thr Arg Val Thr Val Leu Gly 
        355                 360                 365             


His Val Gln Arg Gly Gly Thr Pro Ser Ala Phe Asp Arg Ile Leu Gly 
    370                 375                 380                 


Ser Arg Met Gly Val Glu Ala Val Met Ala Leu Leu Glu Gly Thr Pro 
385                 390                 395                 400 


Asp Thr Pro Ala Cys Val Val Ser Leu Ser Gly Asn Gln Ala Val Arg 
                405                 410                 415     


Leu Pro Leu Met Glu Cys Val Gln Val Thr Lys Asp Val Thr Lys Ala 
            420                 425                 430         


Met Asp Glu Lys Lys Phe Asp Glu Ala Leu Lys Leu Arg Gly Arg Ser 
        435                 440                 445             


Phe Met Asn Asn Trp Glu Val Tyr Lys Leu Leu Ala His Val Arg Pro 
    450                 455                 460                 


Pro Val Ser Lys Ser Gly Ser His Thr Val Ala Val Met Asn Val Gly 
465                 470                 475                 480 


Ala Pro Ala Ala Gly Met Asn Ala Ala Val Arg Ser Thr Val Arg Ile 
                485                 490                 495     


Gly Leu Ile Gln Gly Asn Arg Val Leu Val Val His Asp Gly Phe Glu 
            500                 505                 510         


Gly Leu Ala Lys Gly Gln Ile Glu Glu Ala Gly Trp Ser Tyr Val Gly 
        515                 520                 525             


Gly Trp Thr Gly Gln Gly Gly Ser Lys Leu Gly Thr Lys Arg Thr Leu 
    530                 535                 540                 


Pro Lys Lys Ser Phe Glu Gln Ile Ser Ala Asn Ile Thr Lys Phe Asn 
545                 550                 555                 560 


Ile Gln Gly Leu Val Ile Ile Gly Gly Phe Glu Ala Tyr Thr Gly Gly 
                565                 570                 575     


Leu Glu Leu Met Glu Gly Arg Lys Gln Phe Asp Glu Leu Cys Ile Pro 
            580                 585                 590         


Phe Val Val Ile Pro Ala Thr Val Ser Asn Asn Val Pro Gly Ser Asp 
        595                 600                 605             


Phe Ser Val Gly Ala Asp Thr Ala Leu Asn Thr Ile Cys Thr Thr Cys 
    610                 615                 620                 


Asp Arg Ile Lys Gln Ser Ala Ala Gly Thr Lys Arg Arg Val Phe Ile 
625                 630                 635                 640 


Ile Glu Thr Met Gly Gly Tyr Cys Gly Tyr Leu Ala Thr Met Ala Gly 
                645                 650                 655     


Leu Ala Ala Gly Ala Asp Ala Ala Tyr Ile Phe Glu Glu Pro Phe Thr 
            660                 665                 670         


Ile Arg Asp Leu Gln Ala Asn Val Glu His Leu Val Gln Lys Met Lys 
        675                 680                 685             


Thr Thr Val Lys Arg Gly Leu Val Leu Arg Asn Glu Lys Cys Asn Glu 
    690                 695                 700                 


Asn Tyr Thr Thr Asp Phe Ile Phe Asn Leu Tyr Ser Glu Glu Gly Lys 
705                 710                 715                 720 


Gly Ile Phe Asp Ser Arg Lys Asn Val Leu Gly His Met Gln Gln Gly 
                725                 730                 735     


Gly Ser Pro Thr Pro Phe Asp Arg Asn Phe Ala Thr Lys Met Gly Ala 
            740                 745                 750         


Lys Ala Met Asn Trp Met Ser Gly Lys Ile Lys Glu Ser Tyr Arg Asn 
        755                 760                 765             


Gly Arg Ile Phe Ala Asn Thr Pro Asp Ser Gly Cys Val Leu Gly Met 
    770                 775                 780                 


Arg Lys Arg Ala Leu Val Phe Gln Pro Val Ala Glu Leu Lys Asp Gln 
785                 790                 795                 800 


Thr Asp Phe Glu His Arg Ile Pro Lys Glu Gln Trp Trp Leu Lys Leu 
                805                 810                 815     


Arg Pro Ile Leu Lys Ile Leu Ala Lys Tyr Glu Ile Asp Leu Asp Thr 
            820                 825                 830         


Ser Asp His Ala His Leu Glu His Ile Thr Arg Lys Arg Ser Gly Glu 
        835                 840                 845             


Ala Ala Val 
    850     


<210> 265
<211> 3522
<212> DNA
<213> Homo sapiens

<400> 265
gccccatcac gtgaccgcag ccccagcgcg gcggggccgg cgtctcctgg ctgccgtcac       60

ttccggttct ctgtcagtcg cgagcgaacg accaagaggg tgttcgactg ctagagccga      120

gcgaagcgat gcctaaatca aaggaacttg tttcttcaag ctcttctggc agtgattctg      180

acagtgaggt tgacaaaaag ttaaagagga aaaagcaagt tgctccagaa aaacctgtaa      240

agaaacaaaa gacaggtgag acttcgagag ccctgtcatc ttctaaacag agcagcagca      300

gcagagatga taacatgttt cagattggga aaatgaggta cgttagtgtt cgcgatttta      360

aaggcaaagt gctaattgat attagagaat attggatgga tcctgaaggt gaaatgaaac      420

caggaagaaa aggtatttct ttaaatccag aacaatggag ccagctgaag gaacagattt      480

ctgacattga tgatgcagta agaaaactgt aaaattcgag ccatataaat aaaacctgta      540

ctgttctagt tgttttaatc tgtcttttta cattggcttt tgttttctaa atgttctcca      600

agctattgta tgtttggatt gcagaagaat ttgtaagatg aatacttttt tttaatgtgc      660

attattaaaa atattgagtg aagctaattg tcaactttat taaggattac tttgtctgcc      720

caccacctag tgtaaaataa aatcaagtaa tacaatctta actgttgtgg ccttttttga      780

tcataagagt tggtactgtt taaggccaaa agtaacagtt tttatagatc ttttagtttc      840

aactcagctt ttacaataaa aaggatttgt attgcattga gtttataaac ttttggtttg      900

tgaacttcat atttgatctt ttctcttcca atcaaatgtc taggcttgtt tgacttccac      960

ccccaatggt ttttcactct ttttatttac ttcattttcc tttaataact taatctcttc     1020

atgttcagtt tttacttcac tctttattct tttctttgat tatggtatgc ttatttggaa     1080

agtcagtgaa actgtcaaaa tgttatctca ataagatact tatatgagaa ctacaatcac     1140

cgaatctact gtattcaata ttagcagatc taatttgata aacaacatgg cttgtgtgaa     1200

aactgagcag gtgtttgttt acccatagtg ttctgtgtag ttattgctta gtctgcagaa     1260

aataatgact tagatgagat gtctgacttg ctttcactta ttaaacatgt tcaccatggg     1320

atgatgtctg taacatcaga tattgttcaa ctagactagg atttaataaa aattgtgaaa     1380

gcttactggc ctaacatttt attttataat attgggtatg aattatatgt agccagagat     1440

gtcattaagc tttactgtta tagtaggtaa tatggttagt ttgtagggaa aagagcatat     1500

gagcacatgc ttgtgtattt tggcctttgc cccagtagaa cagaccaatg gcattctaga     1560

cttgatgata ctaagtttta gcagacacta gtaagtggtt tgtatttaac catactgatg     1620

aagcagacag attgaggcac agattttagt ggctttgtgg caataaatag ggcatggtgt     1680

gccttaggaa aagaatgttt ataaagggaa ttataactga aattaaagga ggcggcagtg     1740

aagaggaaat aattctcttc tatctaaatg atatacatat gatattttga gatttttata     1800

acagcagtgg aacacaattc taggtagagt agaaaaagga aagttttaaa gacatataaa     1860

agattcttgt tgacaaatta tttttggtag caaatctcaa atggttacct gctattaagg     1920

tctgccatat tagagttttg cactattttg ctaccaagtt tgattcatac atctaaaaca     1980

ttttgtagtt acttgtcaag gacttaattt gaaaatcatt tgccaggcca catagttatc     2040

aatttttttt tctatcagct attctgttgt atttctaaaa cattttttag atgacttttt     2100

aaagtatatt tagcagtaac cttatgaggt tcaaattggt aaatctcttg taatttagcc     2160

ttcatcgaat aataggtacc agtgtattaa aaatgtgtat tttttgcagc cccttgaacc     2220

agagtaggtt cagagaaact cccaaagttt gtactttaga cacatcatgc ttgattggta     2280

acttccctcc ttttttgggg aacatgtttg tgtcctatta acttaattgg atagattttt     2340

aaatatttct tatttttggc acacggaaag ggtagttcga gtacagaact ttgatttttg     2400

gtgtagatgc agagggaatg atgggtaaat ttcctaggtt tatgtgaatt tagggggtgt     2460

atgcattttg aaacaatcta ctaacagatg gtgctgaaat ctattaccta catgttttct     2520

agttgttcag cattatgtta atgaagcctc catataagga gtgtttctct ggcacagttg     2580

gtaagttgac tgctaacttc atttaaatgt gttactggat atgcagtata ctgaaattat     2640

taatcagttt gtgtatagga aaagagaact gggttaaaag caaattaact tgttctgaaa     2700

agaaagtata gattaatttt gttttctgtt taaattttat ctccttggta aagatttttt     2760

tttcctgggc agaaaacttg gcatttttag gcgtagatac cttaccttac aatgccaaaa     2820

tgaatttaat tccagtactc aggtttttcc ctttaacaga ctctatgtgt atcagggctt     2880

tctaatgggt ttttcctctt cgtttttaaa atgtgagtag catttgacca atttccagtg     2940

ctcttagcat tttacttaaa gaacaaccac tacaaaagaa aatctttgta atttgattgt     3000

cttttgcttt gcttcattaa tgcctaagaa cttaagaata ctcctacctc attagctact     3060

caagatgctg tgacgatcaa atctattcta cataatgcgt ttagaaacaa agacttgggt     3120

gaaaaatgaa ataagtatat tctgacttgg ctattgaggg gaaaattcag tattaagtgt     3180

tcctcacagg agatatgtta gcagaatact ataaaagttt gaaattttta aaaagtaaaa     3240

gtacttaaat ttaggtatct ctcctgaaat tctttgcagt tcatttttta tggcagttaa     3300

tccagtgaaa cactcaaaag tttttttttt tttaaaagtg tttttccaga taaactgtag     3360

ggtgaacatt cacataatca caaatatgta attctgtaat tgtggaatgc ttgtatgctt     3420

tgttttcgta catcttccat ggagatgtct gaatataata ctccatctgt gaatatttta     3480

aatgttgaaa taaaagtaag aaatgtgaaa aaaaaaaaaa aa                        3522


<210> 266
<211> 127
<212> PRT
<213> Homo sapiens

<400> 266
Met Pro Lys Ser Lys Glu Leu Val Ser Ser Ser Ser Ser Gly Ser Asp 
1               5                   10                  15      


Ser Asp Ser Glu Val Asp Lys Lys Leu Lys Arg Lys Lys Gln Val Ala 
            20                  25                  30          


Pro Glu Lys Pro Val Lys Lys Gln Lys Thr Gly Glu Thr Ser Arg Ala 
        35                  40                  45              


Leu Ser Ser Ser Lys Gln Ser Ser Ser Ser Arg Asp Asp Asn Met Phe 
    50                  55                  60                  


Gln Ile Gly Lys Met Arg Tyr Val Ser Val Arg Asp Phe Lys Gly Lys 
65                  70                  75                  80  


Val Leu Ile Asp Ile Arg Glu Tyr Trp Met Asp Pro Glu Gly Glu Met 
                85                  90                  95      


Lys Pro Gly Arg Lys Gly Ile Ser Leu Asn Pro Glu Gln Trp Ser Gln 
            100                 105                 110         


Leu Lys Glu Gln Ile Ser Asp Ile Asp Asp Ala Val Arg Lys Leu 
        115                 120                 125         


<210> 267
<211> 3581
<212> DNA
<213> Homo sapiens

<400> 267
atacgtggct gccgtctgtc cccgctgagg aggtgcagca gccggagatg gcggcggtgc       60

tgaacgcaga gcgactcgag gtgtccgtcg acggcctcac gctcagcccg gacccggagg      120

agcggcctgg ggcggagggc gccccgctgc tgccgccacc gctgccaccg ccctcgccac      180

ctggatccgg tcgcggcccg ggcgcctcag gggagcagcc cgagcccggg gaggcggcgg      240

ctgggggcgc ggcggaggag gcgcggcggc tggagcagcg ctggggtttc ggcctggagg      300

agttgtacgg cctggcactg cgcttcttca aagaaaaaga tggcaaagca tttcatccaa      360

cttatgaaga aaaattgaag cttgtggcac tgcataagca agttcttatg ggcccatata      420

atccagacac ttgtcctgag gttggattct ttgatgtgtt ggggaatgac aggaggagag      480

aatgggcagc cctgggaaac atgtctaaag aggatgccat ggtggagttt gtcaagctct      540

taaataggtg ttgccatctc ttttcaacat atgttgcgtc ccacaaaata gagaaggaag      600

agcaagaaaa aaaaaggaag gaggaagagg agcgaaggcg gcgtgaagag gaagaaagag      660

aacgtctgca aaaggaggaa gagaaacgta ggagagaaga agaggaaagg cttcgacggg      720

aggaagagga aaggagacgg atagaagaag aaaggcttcg gttggagcag caaaagcagc      780

agataatggc agctttaaac tcccagactg ccgtgcagtt ccagcagtat gcagcccaac      840

agtatccagg gaactacgaa cagcagcaaa ttctcatccg ccagttgcag gagcaacact      900

atcagcagta catgcagcag ttgtatcaag tccagcttgc acagcaacag gcagcattac      960

agaaacaaca ggaagtagta gtggctgggt cttccttgcc tacatcatca aaagtgaatg     1020

caactgtacc aagtaatatg atgtcagtta atggacaggc caaaacacac actgacagct     1080

ccgaaaaaga actggaacca gaagctgcag aagaagccct ggagaatgga ccaaaagaat     1140

ctcttccagt aatagcagct ccatccatgt ggacacgacc tcagatcaaa gacttcaaag     1200

agaagattca gcaggatgca gattccgtga ttacagtggg ccgaggagaa gtggtcactg     1260

ttcgagtacc cacccatgaa gaaggatcat atctcttttg ggaatttgcc acagacaatt     1320

atgacattgg gtttggggtg tattttgaat ggacagactc tccaaacact gctgtcagcg     1380

tgcatgtcag tgagtccagc gatgacgacg aggaggaaga agaaaacatc ggttgtgaag     1440

agaaagccaa aaagaatgcc aacaagcctt tgctggatga gattgtgcct gtgtaccgac     1500

gggactgtca tgaggaggtg tatgctggca gccatcaata tccagggaga ggagtctatc     1560

tcctcaagtt tgacaactcc tactctttgt ggcggtcaaa atcagtctac tacagagtct     1620

attatactag ataaaaatgt tgttacaaag tctggagtct agggttgggc agaagatgac     1680

atttaatttg gaaatttctt tttacttttg tggagcatta gagtcacagt ttaccttatt     1740

gatattggtc tgatggtttg tgaactcttg ctgggaatca aaatttcctt gagactcttt     1800

agcattcata ctttggggtt aaaggagatt cctcagactc atccagccct tgggtgctga     1860

ccagcagagt cactagtgga tgctgaagtt acatgagcta catgttaaat atttaaagtc     1920

tccaaaataa aacaccccaa cgttgacctt acccggctga tggttagccc cttgctgcct     1980

gctccatgtg tcttatgaga gcccgtagtt acagtgtcct ctaatttgaa atccataagt     2040

taacaagtct atatcaggtg cagctggctt tgattaaagg ccatttttaa aacttaaaaa     2100

ctcaacacct cacagattat aatagaaaaa gaaatggcct cagtttgatc tcgttcagaa     2160

tgacccagat tgtttctgct ttgggtgcag ctgtttagtt cagagttata ttacagagaa     2220

ttattttctg agataatctt aaactagaat gttcaaaact aattgataat tgaagtatca     2280

agatacgtag aacacctcag agatttttct tcaggaactt ccacaaactt tgaatccttg     2340

tatctttatt tggtattcat actactagta gcaaaataca ggttttttgt tttgttttgt     2400

tttgttttgg cttcatagag tatctcaaat tgaaactttt ctgcacaaag aataaaatta     2460

aggattttat aaactcaaat tggcacctac tgaattaaaa tacataaaat catttaaata     2520

taattcagca tatgggaagt aacattgcac taatatggaa atcactgcca gagacagtct     2580

attttctttt aatttgttac tacttagtca caaaccccac attattccag tttggaatta     2640

cttattaagg agaattggaa atacatatgc ccatgcttaa attttatagc tttaatttgt     2700

gttatttctt tattgacggg aagaggtaca tctttttttc cttactgaaa acaaatatgg     2760

attaattgcc tcaaatttgt ataagtgatt ggctagtgat tcttgttttc agaagggaga     2820

gtggtataga tagaaaatga caaagatggc aatatacact taatgttgtt attgtatgtt     2880

gttactgaag tacttagatt tttaaaattt caaatcctaa atcacttctt gtaggagggt     2940

tttcattaac tgcagtatat acagttcact acatatgggt tgtttgagtt ttttgtgtgc     3000

tgtatttctt tctgtttttt aatacctggt tttgtacata tctaactctg ttctcttttg     3060

gttgttcaga aactggattt tttttttctt aagcagtgct taatttgtgt tttttaattt     3120

tgattcagaa gtagtcccag ctcataggtg ttcatactgt tacatccaga acatttgtca     3180

ggctctctgt cagctttcat gtacatatgg tatagaaacc atggagttag gcacttcctg     3240

gatttttttt ttatgagaaa aatactgtat ttaaaatgta aaataaactt ttaaaaagca     3300

ggcactaata tatatttctt ccagcctttg attacaaatt tgtccttgca catgttaaga     3360

tgaattatct cctaaaaata tcattgttct tgggagcagt gtatgttact ttacatagca     3420

gcggttcctg tcatgtgttc atgtcagaat atttttggtt ttaaactttc ttattgcctt     3480

tggctgttga ttagtacagt acaagtgcga tttcaaaaag atcttgaaag taatatattt     3540

aatcaattaa aatgtttatc tgtaaaaaaa aaaaaaaaaa a                         3581


<210> 268
<211> 528
<212> PRT
<213> Homo sapiens

<400> 268
Met Ala Ala Val Leu Asn Ala Glu Arg Leu Glu Val Ser Val Asp Gly 
1               5                   10                  15      


Leu Thr Leu Ser Pro Asp Pro Glu Glu Arg Pro Gly Ala Glu Gly Ala 
            20                  25                  30          


Pro Leu Leu Pro Pro Pro Leu Pro Pro Pro Ser Pro Pro Gly Ser Gly 
        35                  40                  45              


Arg Gly Pro Gly Ala Ser Gly Glu Gln Pro Glu Pro Gly Glu Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Ala Glu Glu Ala Arg Arg Leu Glu Gln Arg Trp Gly 
65                  70                  75                  80  


Phe Gly Leu Glu Glu Leu Tyr Gly Leu Ala Leu Arg Phe Phe Lys Glu 
                85                  90                  95      


Lys Asp Gly Lys Ala Phe His Pro Thr Tyr Glu Glu Lys Leu Lys Leu 
            100                 105                 110         


Val Ala Leu His Lys Gln Val Leu Met Gly Pro Tyr Asn Pro Asp Thr 
        115                 120                 125             


Cys Pro Glu Val Gly Phe Phe Asp Val Leu Gly Asn Asp Arg Arg Arg 
    130                 135                 140                 


Glu Trp Ala Ala Leu Gly Asn Met Ser Lys Glu Asp Ala Met Val Glu 
145                 150                 155                 160 


Phe Val Lys Leu Leu Asn Arg Cys Cys His Leu Phe Ser Thr Tyr Val 
                165                 170                 175     


Ala Ser His Lys Ile Glu Lys Glu Glu Gln Glu Lys Lys Arg Lys Glu 
            180                 185                 190         


Glu Glu Glu Arg Arg Arg Arg Glu Glu Glu Glu Arg Glu Arg Leu Gln 
        195                 200                 205             


Lys Glu Glu Glu Lys Arg Arg Arg Glu Glu Glu Glu Arg Leu Arg Arg 
    210                 215                 220                 


Glu Glu Glu Glu Arg Arg Arg Ile Glu Glu Glu Arg Leu Arg Leu Glu 
225                 230                 235                 240 


Gln Gln Lys Gln Gln Ile Met Ala Ala Leu Asn Ser Gln Thr Ala Val 
                245                 250                 255     


Gln Phe Gln Gln Tyr Ala Ala Gln Gln Tyr Pro Gly Asn Tyr Glu Gln 
            260                 265                 270         


Gln Gln Ile Leu Ile Arg Gln Leu Gln Glu Gln His Tyr Gln Gln Tyr 
        275                 280                 285             


Met Gln Gln Leu Tyr Gln Val Gln Leu Ala Gln Gln Gln Ala Ala Leu 
    290                 295                 300                 


Gln Lys Gln Gln Glu Val Val Val Ala Gly Ser Ser Leu Pro Thr Ser 
305                 310                 315                 320 


Ser Lys Val Asn Ala Thr Val Pro Ser Asn Met Met Ser Val Asn Gly 
                325                 330                 335     


Gln Ala Lys Thr His Thr Asp Ser Ser Glu Lys Glu Leu Glu Pro Glu 
            340                 345                 350         


Ala Ala Glu Glu Ala Leu Glu Asn Gly Pro Lys Glu Ser Leu Pro Val 
        355                 360                 365             


Ile Ala Ala Pro Ser Met Trp Thr Arg Pro Gln Ile Lys Asp Phe Lys 
    370                 375                 380                 


Glu Lys Ile Gln Gln Asp Ala Asp Ser Val Ile Thr Val Gly Arg Gly 
385                 390                 395                 400 


Glu Val Val Thr Val Arg Val Pro Thr His Glu Glu Gly Ser Tyr Leu 
                405                 410                 415     


Phe Trp Glu Phe Ala Thr Asp Asn Tyr Asp Ile Gly Phe Gly Val Tyr 
            420                 425                 430         


Phe Glu Trp Thr Asp Ser Pro Asn Thr Ala Val Ser Val His Val Ser 
        435                 440                 445             


Glu Ser Ser Asp Asp Asp Glu Glu Glu Glu Glu Asn Ile Gly Cys Glu 
    450                 455                 460                 


Glu Lys Ala Lys Lys Asn Ala Asn Lys Pro Leu Leu Asp Glu Ile Val 
465                 470                 475                 480 


Pro Val Tyr Arg Arg Asp Cys His Glu Glu Val Tyr Ala Gly Ser His 
                485                 490                 495     


Gln Tyr Pro Gly Arg Gly Val Tyr Leu Leu Lys Phe Asp Asn Ser Tyr 
            500                 505                 510         


Ser Leu Trp Arg Ser Lys Ser Val Tyr Tyr Arg Val Tyr Tyr Thr Arg 
        515                 520                 525             


<210> 269
<211> 1298
<212> DNA
<213> Homo sapiens

<400> 269
gagccagttc caaaatggcg gcaggggtgg ccgggtgggg ggttgaggca gaggagttcg       60

aagatgctcc tgatgtggag ccgctggagc ctacacttag caacatcatc gagcagcgca      120

gcctgaagtg gatcttcgtc gggggcaagg gtggtgtggg caagaccacc tgcagctgca      180

gcctggcagt ccagctctcc aaggggcgtg agagtgttct gatcatctcc acagacccag      240

cacacaacat ctcagatgct tttgaccaga agttctcaaa ggtgcctacc aaggtcaaag      300

gctatgacaa cctctttgct atggagattg accccagcct gggcgtggcg gagctgcctg      360

acgagttctt cgaggaggac aacatgctga gcatgggcaa gaagatgatg caggaggcca      420

tgagcgcatt tcccggcatc gatgaggcca tgagctatgc cgaggtcatg aggctggtga      480

agggcatgaa cttctcggtg gtggtatttg acacggcacc cacgggccac accctgaggc      540

tgctcaactt ccccaccatc gtggagcggg gcctgggccg gcttatgcag atcaagaacc      600

agatcagccc tttcatctca cagatgtgca acatgctggg cctgggggac atgaacgcag      660

accagctggc ctccaagctg gaggagacgc tgcccgtcat ccgctcagtc agcgaacagt      720

tcaaggaccc tgagcagaca actttcatct gcgtatgcat tgctgagttc ctgtccctgt      780

atgagacaga gaggctgatc caggagctgg ccaagtgcaa gattgacaca cacaatataa      840

ttgtcaacca gctcgtcttc cccgaccccg agaagccctg caagatgtgt gaggcccgtc      900

acaagatcca ggccaagtat ctggaccaga tggaggacct gtatgaagac ttccacatcg      960

tgaagctgcc gctgttaccc catgaggtgc ggggggcaga caaggtcaac accttctcgg     1020

ccctcctcct ggagccctac aagcccccca gtgcccagta gcacagctgc cagccccaac     1080

cgctgccatt tcacactcac cctccaccct ccccaccccc tcggggcaga gtttgcacaa     1140

agtccccccc ataatacagg gggagccact tgggcaggag gcagggaggg gtccattccc     1200

cctggtgggg ctggtgggga gctgtagttg ccccctacct ctcccacctc ttgctcttca     1260

ataaaatgat cttaaactgc aaaaaaaaaa aaaaaaaa                             1298


<210> 270
<211> 348
<212> PRT
<213> Homo sapiens

<400> 270
Met Ala Ala Gly Val Ala Gly Trp Gly Val Glu Ala Glu Glu Phe Glu 
1               5                   10                  15      


Asp Ala Pro Asp Val Glu Pro Leu Glu Pro Thr Leu Ser Asn Ile Ile 
            20                  25                  30          


Glu Gln Arg Ser Leu Lys Trp Ile Phe Val Gly Gly Lys Gly Gly Val 
        35                  40                  45              


Gly Lys Thr Thr Cys Ser Cys Ser Leu Ala Val Gln Leu Ser Lys Gly 
    50                  55                  60                  


Arg Glu Ser Val Leu Ile Ile Ser Thr Asp Pro Ala His Asn Ile Ser 
65                  70                  75                  80  


Asp Ala Phe Asp Gln Lys Phe Ser Lys Val Pro Thr Lys Val Lys Gly 
                85                  90                  95      


Tyr Asp Asn Leu Phe Ala Met Glu Ile Asp Pro Ser Leu Gly Val Ala 
            100                 105                 110         


Glu Leu Pro Asp Glu Phe Phe Glu Glu Asp Asn Met Leu Ser Met Gly 
        115                 120                 125             


Lys Lys Met Met Gln Glu Ala Met Ser Ala Phe Pro Gly Ile Asp Glu 
    130                 135                 140                 


Ala Met Ser Tyr Ala Glu Val Met Arg Leu Val Lys Gly Met Asn Phe 
145                 150                 155                 160 


Ser Val Val Val Phe Asp Thr Ala Pro Thr Gly His Thr Leu Arg Leu 
                165                 170                 175     


Leu Asn Phe Pro Thr Ile Val Glu Arg Gly Leu Gly Arg Leu Met Gln 
            180                 185                 190         


Ile Lys Asn Gln Ile Ser Pro Phe Ile Ser Gln Met Cys Asn Met Leu 
        195                 200                 205             


Gly Leu Gly Asp Met Asn Ala Asp Gln Leu Ala Ser Lys Leu Glu Glu 
    210                 215                 220                 


Thr Leu Pro Val Ile Arg Ser Val Ser Glu Gln Phe Lys Asp Pro Glu 
225                 230                 235                 240 


Gln Thr Thr Phe Ile Cys Val Cys Ile Ala Glu Phe Leu Ser Leu Tyr 
                245                 250                 255     


Glu Thr Glu Arg Leu Ile Gln Glu Leu Ala Lys Cys Lys Ile Asp Thr 
            260                 265                 270         


His Asn Ile Ile Val Asn Gln Leu Val Phe Pro Asp Pro Glu Lys Pro 
        275                 280                 285             


Cys Lys Met Cys Glu Ala Arg His Lys Ile Gln Ala Lys Tyr Leu Asp 
    290                 295                 300                 


Gln Met Glu Asp Leu Tyr Glu Asp Phe His Ile Val Lys Leu Pro Leu 
305                 310                 315                 320 


Leu Pro His Glu Val Arg Gly Ala Asp Lys Val Asn Thr Phe Ser Ala 
                325                 330                 335     


Leu Leu Leu Glu Pro Tyr Lys Pro Pro Ser Ala Gln 
            340                 345             


<210> 271
<211> 2187
<212> DNA
<213> Homo sapiens

<400> 271
gttgactcgg ccatcggcct gccgggcctg gcgtttccca gaaggcccag cgccgggaag       60

gggtttgcag ctgctccgtc atcgtgcggc ccgacgctat ctcgcgctcg tgtgcaggcc      120

cggctcggct cctggtcccc ggtgcgaggg ttaacgcgag gccccggcct cggtccccgg      180

actaggccgt gaccccgggt gccatgaagc aggagggctc ggcgcggcgc cgcggcgcgg      240

acaaggcgaa accgccgccc ggcggaggag aacaagaacc cccaccgccg ccggcccccc      300

aggatgtgga gatgaaagag gaggcagcga cgggtggcgg gtcgacgggg gaggcagacg      360

gcaagacggc ggcggcagcg gctgagcact cccagcgaga gctggacaca gtcaccttgg      420

aggacatcaa ggagcacgtg aaacagctag agaaagcggt ttcaggcaag gagccgagat      480

tcgtgctgcg ggccctgcgg atgctgcctt ccacatcacg ccgcctcaac cactatgttc      540

tgtataaggc tgtgcagggc ttcttcactt caaataatgc cactcgagac tttttgctcc      600

ccttcctgga agagcccatg gacacagagg ctgatttaca gttccgtccc cgcacgggaa      660

aagctgcgtc gacacccctc ctgcctgaag tggaagccta tctccaactc ctcgtggtca      720

tcttcatgat gaacagcaag cgctacaaag aggcacagaa gatctctgat gatctgatgc      780

agaagatcag tactcagaac cgccgggccc tagaccttgt agccgcaaag tgttactatt      840

atcacgcccg ggtctatgag ttcctggaca agctggatgt ggtgcgcagc ttcttgcatg      900

ctcggctccg gacagctacg cttcggcatg acgcagacgg gcaggccacc ctgttgaacc      960

tcctgctgcg gaattaccta cactacagct tgtacgacca ggctgagaag ctggtgtcca     1020

agtctgtgtt cccagagcag gccaacaaca atgagtgggc caggtacctc tactacacag     1080

ggcgaatcaa agccatccag ctggagtact cagaggcccg gagaacgatg accaacgccc     1140

ttcgcaaggc ccctcagcac acagctgtcg gcttcaaaca gacggtgcac aagcttctca     1200

tcgtggtgga gctgttgctg ggggagatcc ctgaccggct gcagttccgc cagccctccc     1260

tcaagcgctc actcatgccc tatttccttc tgactcaagc tgtcaggaca ggaaacctag     1320

ccaagttcaa ccaggtcctg gatcagtttg gggagaagtt tcaagcagat gggacctaca     1380

ccctaattat ccggctgcgg cacaacgtga ttaagacagg tgtacgcatg atcagcctct     1440

cctattcccg aatctccttg gctgacatcg cccagaagct gcagttggat agccccgaag     1500

atgcagagtt cattgttgcc aaggccatcc gggatggtgt cattgaggcc agcatcaacc     1560

acgagaaggg ctatgtccaa tccaaggaga tgattgacat ctattccacc cgagagcccc     1620

agctagcctt ccaccagcgc atctccttct gcctagatat ccacaacatg tctgtcaagg     1680

ccatgaggtt tcctcccaaa tcgtacaaca aggacttgga gtctgcagag gaacggcgtg     1740

agcgagaaca gcaggacttg gagtttgcca aggagatggc agaagatgat gatgacagct     1800

tcccttgagc tggggggctg gggaggggta gggggaatgg ggacaggctc tttccccctt     1860

gggggtcccc tgcccagggc actgtcccca ttttcccaca cacagctcat atgctgcatt     1920

cgtgcagggg gtgggggtgc tgggagccag ccaccctgac ctcccccagg gctcctcccc     1980

agccggtgac ttactgtaca gcaggcagga gggtgggcag gcaacctccc cgggcagggt     2040

cctggccagc agtgtgggag caggagggga aggatagttc tgtgtactcc tttagggagt     2100

gggggactag aactgggatg tcttggcttg tatgtttttt gaagcttcga ttatgatttt     2160

taaacaataa aaagttctcc acagtgc                                         2187


<210> 272
<211> 534
<212> PRT
<213> Homo sapiens

<400> 272
Met Lys Gln Glu Gly Ser Ala Arg Arg Arg Gly Ala Asp Lys Ala Lys 
1               5                   10                  15      


Pro Pro Pro Gly Gly Gly Glu Gln Glu Pro Pro Pro Pro Pro Ala Pro 
            20                  25                  30          


Gln Asp Val Glu Met Lys Glu Glu Ala Ala Thr Gly Gly Gly Ser Thr 
        35                  40                  45              


Gly Glu Ala Asp Gly Lys Thr Ala Ala Ala Ala Ala Glu His Ser Gln 
    50                  55                  60                  


Arg Glu Leu Asp Thr Val Thr Leu Glu Asp Ile Lys Glu His Val Lys 
65                  70                  75                  80  


Gln Leu Glu Lys Ala Val Ser Gly Lys Glu Pro Arg Phe Val Leu Arg 
                85                  90                  95      


Ala Leu Arg Met Leu Pro Ser Thr Ser Arg Arg Leu Asn His Tyr Val 
            100                 105                 110         


Leu Tyr Lys Ala Val Gln Gly Phe Phe Thr Ser Asn Asn Ala Thr Arg 
        115                 120                 125             


Asp Phe Leu Leu Pro Phe Leu Glu Glu Pro Met Asp Thr Glu Ala Asp 
    130                 135                 140                 


Leu Gln Phe Arg Pro Arg Thr Gly Lys Ala Ala Ser Thr Pro Leu Leu 
145                 150                 155                 160 


Pro Glu Val Glu Ala Tyr Leu Gln Leu Leu Val Val Ile Phe Met Met 
                165                 170                 175     


Asn Ser Lys Arg Tyr Lys Glu Ala Gln Lys Ile Ser Asp Asp Leu Met 
            180                 185                 190         


Gln Lys Ile Ser Thr Gln Asn Arg Arg Ala Leu Asp Leu Val Ala Ala 
        195                 200                 205             


Lys Cys Tyr Tyr Tyr His Ala Arg Val Tyr Glu Phe Leu Asp Lys Leu 
    210                 215                 220                 


Asp Val Val Arg Ser Phe Leu His Ala Arg Leu Arg Thr Ala Thr Leu 
225                 230                 235                 240 


Arg His Asp Ala Asp Gly Gln Ala Thr Leu Leu Asn Leu Leu Leu Arg 
                245                 250                 255     


Asn Tyr Leu His Tyr Ser Leu Tyr Asp Gln Ala Glu Lys Leu Val Ser 
            260                 265                 270         


Lys Ser Val Phe Pro Glu Gln Ala Asn Asn Asn Glu Trp Ala Arg Tyr 
        275                 280                 285             


Leu Tyr Tyr Thr Gly Arg Ile Lys Ala Ile Gln Leu Glu Tyr Ser Glu 
    290                 295                 300                 


Ala Arg Arg Thr Met Thr Asn Ala Leu Arg Lys Ala Pro Gln His Thr 
305                 310                 315                 320 


Ala Val Gly Phe Lys Gln Thr Val His Lys Leu Leu Ile Val Val Glu 
                325                 330                 335     


Leu Leu Leu Gly Glu Ile Pro Asp Arg Leu Gln Phe Arg Gln Pro Ser 
            340                 345                 350         


Leu Lys Arg Ser Leu Met Pro Tyr Phe Leu Leu Thr Gln Ala Val Arg 
        355                 360                 365             


Thr Gly Asn Leu Ala Lys Phe Asn Gln Val Leu Asp Gln Phe Gly Glu 
    370                 375                 380                 


Lys Phe Gln Ala Asp Gly Thr Tyr Thr Leu Ile Ile Arg Leu Arg His 
385                 390                 395                 400 


Asn Val Ile Lys Thr Gly Val Arg Met Ile Ser Leu Ser Tyr Ser Arg 
                405                 410                 415     


Ile Ser Leu Ala Asp Ile Ala Gln Lys Leu Gln Leu Asp Ser Pro Glu 
            420                 425                 430         


Asp Ala Glu Phe Ile Val Ala Lys Ala Ile Arg Asp Gly Val Ile Glu 
        435                 440                 445             


Ala Ser Ile Asn His Glu Lys Gly Tyr Val Gln Ser Lys Glu Met Ile 
    450                 455                 460                 


Asp Ile Tyr Ser Thr Arg Glu Pro Gln Leu Ala Phe His Gln Arg Ile 
465                 470                 475                 480 


Ser Phe Cys Leu Asp Ile His Asn Met Ser Val Lys Ala Met Arg Phe 
                485                 490                 495     


Pro Pro Lys Ser Tyr Asn Lys Asp Leu Glu Ser Ala Glu Glu Arg Arg 
            500                 505                 510         


Glu Arg Glu Gln Gln Asp Leu Glu Phe Ala Lys Glu Met Ala Glu Asp 
        515                 520                 525             


Asp Asp Asp Ser Phe Pro 
    530                 


<210> 273
<211> 2339
<212> DNA
<213> Homo sapiens

<400> 273
cctgtggtcc cgggtttctg cagagtctac ttcagaagcg gaggcactgg gagtccggtt       60

tgggattgcc aggctgtggt tgtgagtctg agcttgtgag cggctgtggc gccccaactc      120

ttcgccagca tatcatcccg gcaggcgata aactacattc agttgagtct gcaagactgg      180

gaggaactgg ggtgataaga aatctattca ctgtcaaggt ttattgaagt caaaatgtcc      240

aaaaaaatca gtggcggttc tgtggtagag atgcaaggag atgaaatgac acgaatcatt      300

tgggaattga ttaaagagaa actcattttt ccctacgtgg aattggatct acatagctat      360

gatttaggca tagagaatcg tgatgccacc aacgaccaag tcaccaagga tgctgcagaa      420

gctataaaga agcataatgt tggcgtcaaa tgtgccacta tcactcctga tgagaagagg      480

gttgaggagt tcaagttgaa acaaatgtgg aaatcaccaa atggcaccat acgaaatatt      540

ctgggtggca cggtcttcag agaagccatt atctgcaaaa atatcccccg gcttgtgagt      600

ggatgggtaa aacctatcat cataggtcgt catgcttatg gggatcaata cagagcaact      660

gattttgttg ttcctgggcc tggaaaagta gagataacct acacaccaag tgacggaacc      720

caaaaggtga catacctggt acataacttt gaagaaggtg gtggtgttgc catggggatg      780

tataatcaag ataagtcaat tgaagatttt gcacacagtt ccttccaaat ggctctgtct      840

aagggttggc ctttgtatct gagcaccaaa aacactattc tgaagaaata tgatgggcgt      900

tttaaagaca tctttcagga gatatatgac aagcagtaca agtcccagtt tgaagctcaa      960

aagatctggt atgagcatag gctcatcgac gacatggtgg cccaagctat gaaatcagag     1020

ggaggcttca tctgggcctg taaaaactat gatggtgacg tgcagtcgga ctctgtggcc     1080

caagggtatg gctctctcgg catgatgacc agcgtgctgg tttgtccaga tggcaagaca     1140

gtagaagcag aggctgccca cgggactgta acccgtcact accgcatgta ccagaaagga     1200

caggagacgt ccaccaatcc cattgcttcc atttttgcct ggaccagagg gttagcccac     1260

agagcaaagc ttgataacaa taaagagctt gccttctttg caaatgcttt ggaagaagtc     1320

tctattgaga caattgaggc tggcttcatg accaaggact tggctgcttg cattaaaggt     1380

ttacccaatg tgcaacgttc tgactacttg aatacatttg agttcatgga taaacttgga     1440

gaaaacttga agatcaaact agctcaggcc aaactttaag ttcatacctg agctaagaag     1500

gataattgtc ttttggtaac taggtctaca ggtttacatt tttctgtgtt acactcaagg     1560

ataaaggcaa aatcaatttt gtaatttgtt tagaagccag agtttatctt ttctataagt     1620

ttacagcctt tttcttatat atacagttat tgccaccttt gtgaacatgg caagggactt     1680

ttttacaatt tttattttat tttctagtac cagcctagga attcggttag tactcatttg     1740

tattcactgt cactttttct catgttctaa ttataaatga ccaaaatcaa gattgctcaa     1800

aagggtaaat gatagccaca gtattgctcc ctaaaatatg cataaagtag aaattcactg     1860

ccttcccctc ctgtccatga ccttgggcac agggaagttc tggtgtcata gatatcccgt     1920

tttgtgaggt agagctgtgc attaaacttg cacatgactg gaacgaagta tgagtgcaac     1980

tcaaatgtgt tgaagatact gcagtcattt ttgtaaagac cttgctgaat gtttccaata     2040

gactaaatac tgtttaggcc gcaggagagt ttggaatccg gaataaatac tacctggagg     2100

tttgtcctct ccatttttct ctttctcctc ctggcctggc ctgaatatta tactactcta     2160

aatagcatat ttcatccaag tgcaataatg taagctgaat cttttttgga cttctgctgg     2220

cctgttttat ttcttttata taaatgtgat ttctcagaaa ttgatattaa acactatctt     2280

atcttctcct gaactgttga ttttaattaa aattaagtgc taattaccaa aaaaaaaaa      2339


<210> 274
<211> 414
<212> PRT
<213> Homo sapiens

<400> 274
Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 
1               5                   10                  15      


Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 
            20                  25                  30          


Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 
        35                  40                  45              


Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 
    50                  55                  60                  


Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 
            100                 105                 110         


Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 
    130                 135                 140                 


Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp 
145                 150                 155                 160 


Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 
                165                 170                 175     


Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 
            180                 185                 190         


Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 
        195                 200                 205             


Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 
    210                 215                 220                 


Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 
225                 230                 235                 240 


Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 
        275                 280                 285             


Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 
    290                 295                 300                 


Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 
305                 310                 315                 320 


Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 
            340                 345                 350         


Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 
        355                 360                 365             


Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 
    370                 375                 380                 


Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 
385                 390                 395                 400 


Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 
                405                 410                 


<210> 275
<211> 4205
<212> DNA
<213> Homo sapiens

<400> 275
ctccctcgct ccctccctgc gcgccgcctc tcactcacag cctcccttcc ttctttctcc       60

ctccgcctcc cgagcaccag cgcgctctga gctgccccca gggtccctcc cccgccgcca      120

gcagcccatt tggagggagg aagtaaggga agaggagagg aaggggagcc ggaccgacta      180

cccagacaga gccggtgaat gggtttgtgg tgacccccgc cccccacccc accctccctt      240

cccacccgac ccccaacccc catccccagt tcgagccgcc gcccgaaagg ccgggccgtc      300

gtcttaggag gagtcgccgc cgccgccacc tccgccatgg agctgatcac cattctcgag      360

aagaccgtgt ctcccgatcg gctggagctg gaagcggcgc agaagttcct ggagcgtgcg      420

gccgtggaga acctgcccac tttccttgtg gaactgtcca gagtgctggc aaatccagga      480

aacagtcagg ttgccagagt tgcagctggt ctacaaatca agaactcttt gacatctaaa      540

gatccagata tcaaggcaca atatcagcag aggtggcttg ctattgatgc taatgctcga      600

cgagaagtca agaactatgt tttgcagaca ttgggtacag aaacttaccg gcctagttct      660

gcctcacagt gtgtggctgg tattgcttgt gcagagatcc cagtaaacca gtggccagaa      720

ctcattcctc agctggtggc caatgtcaca aaccccaaca gcacagagca catgaaggag      780

tcgacattgg aagccatcgg ttatatttgc caagatatag acccagagca gctacaagat      840

aaatccaatg agattctgac tgccataatc caggggatga ggaaagaaga gcctagtaat      900

aatgtgaagc tagctgctac gaatgcactc ctgaactcat tggagttcac caaagcaaac      960

tttgataaag agtctgaaag gcactttatt atgcaggtgg tctgtgaagc cacacagtgt     1020

ccagatacga gggtacgagt ggctgcttta cagaatctgg tgaagataat gtccttatat     1080

tatcagtaca tggagacata tatgggtcct gctctttttg caatcacaat cgaagcaatg     1140

aaaagtgaca ttgatgaggt ggctttacaa gggatagaat tctggtccaa tgtctgtgat     1200

gaggaaatgg atttggccat tgaagcttca gaggcagcag aacaaggacg gccccctgag     1260

cacaccagca agttttatgc gaagggagca ctacagtatc tggttccaat cctcacacag     1320

acactaacta aacaggacga aaatgatgat gacgatgact ggaacccctg caaagcagca     1380

ggggtgtgcc tcatgcttct ggccacctgc tgtgaagatg acattgtccc acatgtcctc     1440

cccttcatta aagaacacat caagaaccca gattggcggt accgggatgc agcagtgatg     1500

gcttttggtt gtatcttgga aggaccagag cccagtcagc tcaaaccact agttatacag     1560

gctatgccca ccctaataga attaatgaaa gaccccagtg tagttgttcg agatacagct     1620

gcatggactg taggcagaat ttgtgagctg cttcctgaag ctgccatcaa tgatgtctac     1680

ttggctcccc tgctacagtg tctgattgag ggtctcagtg ctgaacccag agtggcttca     1740

aatgtgtgct gggctttctc cagtctggct gaagctgctt atgaagctgc agacgttgct     1800

gatgatcagg aagaaccagc tacttactgc ttatcttctt catttgaact catagttcag     1860

aagctcctag agactacaga cagacctgat ggacaccaga acaacctgag gagttctgca     1920

tatgaatctc tgatggaaat tgtgaaaaac agtgccaagg attgttatcc tgctgtccag     1980

aaaacgactt tggtcatcat ggaacgactg caacaggttc ttcagatgga gtcacatatc     2040

cagagcacat ccgatagaat ccagttcaat gaccttcagt ctttactctg tgcaactctt     2100

cagaatgttc ttcggaaagt gcaacatcaa gatgctttgc agatctctga tgtggttatg     2160

gcctccctgt taaggatgtt ccaaagcaca gctgggtctg ggggagtaca agaggatgcc     2220

ctgatggcag ttagcacact ggtggaagtg ttgggtggtg aattcctcaa gtacatggag     2280

gcctttaaac ccttcctggg cattggatta aaaaattatg ctgaatacca ggtttgtttg     2340

gcagctgtgg gcttagtggg agacttgtgc cgtgccctgc aatccaacat catacctttc     2400

tgtgacgagg tgatgcagct gcttctggaa aatttgggga atgagaacgt ccacaggtct     2460

gtgaagccgc agattctgtc agtgtttggt gatattgccc ttgctattgg aggagagttt     2520

aaaaaatact tagaggttgt attgaatact cttcagcagg cctcccaagc ccaggtggac     2580

aagtcagact atgacatggt ggattatctg aatgagctaa gggaaagctg cttggaagcc     2640

tatactggaa tcgtccaggg attaaagggg gatcaggaga acgtacaccc ggatgtgatg     2700

ctggtacaac ccagagtaga atttattctg tctttcattg accacattgc tggagatgag     2760

gatcacacag atggagtagt agcttgtgct gctggactaa taggggactt atgtacagca     2820

tttgggaagg atgtactgaa attagtagaa gctaggccaa tgatccatga attgttaact     2880

gaagggcgga gatcgaagac taacaaagca aaaacccttg ctacatgggc aacaaaagaa     2940

ctgaggaaac tgaagaacca agcttgatct gttaccattg ggatgataac ctgaggaccc     3000

ccactggaaa tctcccatct tttgaaaaac ctggaagtga ggagtgtgca cggatgctga     3060

atgtttggga atgagaggat gagtgagtga ggcttgaaaa cacaccacat tgaaaatcct     3120

gccacagcag cagccgcagc cgccaacagc agcgctgtta gtgagctaag taagcactga     3180

cttcgtagaa aaccataaca tcggccatct tggaaaagag aaaaacaatg gagttactta     3240

tttaaaaaaa aagaaagaaa gttatctctt cccaggagag gctagaagta gcttttctgt     3300

cttttggcca gtgccgagtg gaatgcctgg tttgggggag gaggagggac tgggttcagc     3360

tgtggtgctt tgttgtaaaa ggcagcctgg cctttgctac tgaggagaaa gatggagcct     3420

gggtctcaag cccaccttcg ctgtaccttt gccacatggt actgtatgct tgccagctag     3480

aaggagggtc agggattttt tacagtctga gaatgagtgt gtgtgagtga ggcggtatcc     3540

acattctcaa cttcaagtca ttgcagtttc tttttcccag aaaacaaggg gttagatgtt     3600

gcatttcata aaactaaccg aagttctgtc tactgatgca gcacaagaga tgtaaaaaaa     3660

aaaaaaaaaa aaaaaaaaaa aacacacaca cagaggaaag acgctcttta ggttttgttt     3720

tgtttttttt ttttggtttt gttttttgtt ttttttactc tagggaaaac actgacgaat     3780

ggtcagagct cctatcctga tcttttcatc aaggcgcctt tcctaataat atggttcaac     3840

tgtgaatgta gaagtggggg ggagggggga gaaaaagaaa actctggcgt tagaggatat     3900

agaaaaatat aagtacaatt gttacaaata acgcagactt caaaaacaaa aaaatcacaa     3960

cccaaacaaa ccaaaattta aatgatcaga attggcagca caaagaaaac gccctctcct     4020

gacttgtatt gtggcagtct gaacgccccc agaaaattgt gccaaagagt ttagaaaaat     4080

aaatatacaa taaaagtaaa cacatacaca caaaacagca aacttcaggt aactattttg     4140

gattgcaaac aggataaatt aaatgttcaa acaatctgat aaaataacca tttggaaact     4200

gaaaa                                                                 4205


<210> 276
<211> 876
<212> PRT
<213> Homo sapiens

<400> 276
Met Glu Leu Ile Thr Ile Leu Glu Lys Thr Val Ser Pro Asp Arg Leu 
1               5                   10                  15      


Glu Leu Glu Ala Ala Gln Lys Phe Leu Glu Arg Ala Ala Val Glu Asn 
            20                  25                  30          


Leu Pro Thr Phe Leu Val Glu Leu Ser Arg Val Leu Ala Asn Pro Gly 
        35                  40                  45              


Asn Ser Gln Val Ala Arg Val Ala Ala Gly Leu Gln Ile Lys Asn Ser 
    50                  55                  60                  


Leu Thr Ser Lys Asp Pro Asp Ile Lys Ala Gln Tyr Gln Gln Arg Trp 
65                  70                  75                  80  


Leu Ala Ile Asp Ala Asn Ala Arg Arg Glu Val Lys Asn Tyr Val Leu 
                85                  90                  95      


Gln Thr Leu Gly Thr Glu Thr Tyr Arg Pro Ser Ser Ala Ser Gln Cys 
            100                 105                 110         


Val Ala Gly Ile Ala Cys Ala Glu Ile Pro Val Asn Gln Trp Pro Glu 
        115                 120                 125             


Leu Ile Pro Gln Leu Val Ala Asn Val Thr Asn Pro Asn Ser Thr Glu 
    130                 135                 140                 


His Met Lys Glu Ser Thr Leu Glu Ala Ile Gly Tyr Ile Cys Gln Asp 
145                 150                 155                 160 


Ile Asp Pro Glu Gln Leu Gln Asp Lys Ser Asn Glu Ile Leu Thr Ala 
                165                 170                 175     


Ile Ile Gln Gly Met Arg Lys Glu Glu Pro Ser Asn Asn Val Lys Leu 
            180                 185                 190         


Ala Ala Thr Asn Ala Leu Leu Asn Ser Leu Glu Phe Thr Lys Ala Asn 
        195                 200                 205             


Phe Asp Lys Glu Ser Glu Arg His Phe Ile Met Gln Val Val Cys Glu 
    210                 215                 220                 


Ala Thr Gln Cys Pro Asp Thr Arg Val Arg Val Ala Ala Leu Gln Asn 
225                 230                 235                 240 


Leu Val Lys Ile Met Ser Leu Tyr Tyr Gln Tyr Met Glu Thr Tyr Met 
                245                 250                 255     


Gly Pro Ala Leu Phe Ala Ile Thr Ile Glu Ala Met Lys Ser Asp Ile 
            260                 265                 270         


Asp Glu Val Ala Leu Gln Gly Ile Glu Phe Trp Ser Asn Val Cys Asp 
        275                 280                 285             


Glu Glu Met Asp Leu Ala Ile Glu Ala Ser Glu Ala Ala Glu Gln Gly 
    290                 295                 300                 


Arg Pro Pro Glu His Thr Ser Lys Phe Tyr Ala Lys Gly Ala Leu Gln 
305                 310                 315                 320 


Tyr Leu Val Pro Ile Leu Thr Gln Thr Leu Thr Lys Gln Asp Glu Asn 
                325                 330                 335     


Asp Asp Asp Asp Asp Trp Asn Pro Cys Lys Ala Ala Gly Val Cys Leu 
            340                 345                 350         


Met Leu Leu Ala Thr Cys Cys Glu Asp Asp Ile Val Pro His Val Leu 
        355                 360                 365             


Pro Phe Ile Lys Glu His Ile Lys Asn Pro Asp Trp Arg Tyr Arg Asp 
    370                 375                 380                 


Ala Ala Val Met Ala Phe Gly Cys Ile Leu Glu Gly Pro Glu Pro Ser 
385                 390                 395                 400 


Gln Leu Lys Pro Leu Val Ile Gln Ala Met Pro Thr Leu Ile Glu Leu 
                405                 410                 415     


Met Lys Asp Pro Ser Val Val Val Arg Asp Thr Ala Ala Trp Thr Val 
            420                 425                 430         


Gly Arg Ile Cys Glu Leu Leu Pro Glu Ala Ala Ile Asn Asp Val Tyr 
        435                 440                 445             


Leu Ala Pro Leu Leu Gln Cys Leu Ile Glu Gly Leu Ser Ala Glu Pro 
    450                 455                 460                 


Arg Val Ala Ser Asn Val Cys Trp Ala Phe Ser Ser Leu Ala Glu Ala 
465                 470                 475                 480 


Ala Tyr Glu Ala Ala Asp Val Ala Asp Asp Gln Glu Glu Pro Ala Thr 
                485                 490                 495     


Tyr Cys Leu Ser Ser Ser Phe Glu Leu Ile Val Gln Lys Leu Leu Glu 
            500                 505                 510         


Thr Thr Asp Arg Pro Asp Gly His Gln Asn Asn Leu Arg Ser Ser Ala 
        515                 520                 525             


Tyr Glu Ser Leu Met Glu Ile Val Lys Asn Ser Ala Lys Asp Cys Tyr 
    530                 535                 540                 


Pro Ala Val Gln Lys Thr Thr Leu Val Ile Met Glu Arg Leu Gln Gln 
545                 550                 555                 560 


Val Leu Gln Met Glu Ser His Ile Gln Ser Thr Ser Asp Arg Ile Gln 
                565                 570                 575     


Phe Asn Asp Leu Gln Ser Leu Leu Cys Ala Thr Leu Gln Asn Val Leu 
            580                 585                 590         


Arg Lys Val Gln His Gln Asp Ala Leu Gln Ile Ser Asp Val Val Met 
        595                 600                 605             


Ala Ser Leu Leu Arg Met Phe Gln Ser Thr Ala Gly Ser Gly Gly Val 
    610                 615                 620                 


Gln Glu Asp Ala Leu Met Ala Val Ser Thr Leu Val Glu Val Leu Gly 
625                 630                 635                 640 


Gly Glu Phe Leu Lys Tyr Met Glu Ala Phe Lys Pro Phe Leu Gly Ile 
                645                 650                 655     


Gly Leu Lys Asn Tyr Ala Glu Tyr Gln Val Cys Leu Ala Ala Val Gly 
            660                 665                 670         


Leu Val Gly Asp Leu Cys Arg Ala Leu Gln Ser Asn Ile Ile Pro Phe 
        675                 680                 685             


Cys Asp Glu Val Met Gln Leu Leu Leu Glu Asn Leu Gly Asn Glu Asn 
    690                 695                 700                 


Val His Arg Ser Val Lys Pro Gln Ile Leu Ser Val Phe Gly Asp Ile 
705                 710                 715                 720 


Ala Leu Ala Ile Gly Gly Glu Phe Lys Lys Tyr Leu Glu Val Val Leu 
                725                 730                 735     


Asn Thr Leu Gln Gln Ala Ser Gln Ala Gln Val Asp Lys Ser Asp Tyr 
            740                 745                 750         


Asp Met Val Asp Tyr Leu Asn Glu Leu Arg Glu Ser Cys Leu Glu Ala 
        755                 760                 765             


Tyr Thr Gly Ile Val Gln Gly Leu Lys Gly Asp Gln Glu Asn Val His 
    770                 775                 780                 


Pro Asp Val Met Leu Val Gln Pro Arg Val Glu Phe Ile Leu Ser Phe 
785                 790                 795                 800 


Ile Asp His Ile Ala Gly Asp Glu Asp His Thr Asp Gly Val Val Ala 
                805                 810                 815     


Cys Ala Ala Gly Leu Ile Gly Asp Leu Cys Thr Ala Phe Gly Lys Asp 
            820                 825                 830         


Val Leu Lys Leu Val Glu Ala Arg Pro Met Ile His Glu Leu Leu Thr 
        835                 840                 845             


Glu Gly Arg Arg Ser Lys Thr Asn Lys Ala Lys Thr Leu Ala Thr Trp 
    850                 855                 860                 


Ala Thr Lys Glu Leu Arg Lys Leu Lys Asn Gln Ala 
865                 870                 875     


<210> 277
<211> 4805
<212> DNA
<213> Homo sapiens

<400> 277
gttaagttgg agccgactca gcggcggccg ccattttgtg cagtcgctgg gaaggaagga       60

gacgcctaaa ccgcggcact gcccggtttg agcgtagcca aacctgccca ccggctttgt      120

agccccgatt ctctgtgttt tgctcccgtc tccgacgaga gaggcggcga cggtggcgtc      180

tgcgacggga gacagcgcgt cggagcgaga gagcgctgcg cctgccgccg ccccaacagc      240

ggaggcgccg ccgccatcgg tcgtcaccag accggagccg caggccctcc cgagcccggc      300

catccgtgcc ccgctcccag atctctatcc ttttgggacc atgcgcggag gaggctttgg      360

ggaccgggac cgggatcgtg accgtggagg atttggagca agaggtggtg gtggccttcc      420

cccgaagaaa tttggtaatc ctggggagcg tttgcgtaaa aaaaagtggg atttgagtga      480

gctccccaag tttgagaaaa atttttatgt ggaacatccg gaagtagcaa ggctgacacc      540

atatgaggtt gatgagctac gccgaaagaa ggagattaca gtgagggggg gagatgtttg      600

tcctaaaccc gtgtttgcct tccatcatgc taacttccca caatatgtaa tggatgtgtt      660

gatggatcag cactttacag aaccaactcc aattcagtgc cagggatttc cgttggctct      720

tagtggccgg gatatggtgg gcattgctca gactggctct gggaagacgt tggcgtatct      780

cctgcctgca attgttcata ttaaccacca gccatacttg gaaaggggag atggcccaat      840

ctgtctagtt ctggctccta ccagagagct tgcccagcaa gtacagcagg tggccgatga      900

ctatggcaaa tgttctagat tgaagagtac ttgtatttat ggaggtgctc ctaaaggtcc      960

ccagattcga gacttggaaa gaggtgttga gatctgcata gccactcctg gacgtctgat     1020

agatttcctg gagtcaggaa agacaaatct tcgccgatgt acttaccttg tattggacga     1080

agctgacaga atgcttgata tggggtttga accccagatc cgtaaaattg ttgaccaaat     1140

caggcctgat aggcagacac tgatgtggag tgcaacctgg ccaaaagaag taagacagct     1200

tgcagaggat ttccttcgtg attacaccca gatcaacgta ggcaatctgg agttgagtgc     1260

caaccacaac atcctccaga tagtggatgt ctgcatggaa agtgaaaaag accacaagtt     1320

gatccaacta atggaagaaa taatggctga aaaggaaaac aaaacaataa tatttgtgga     1380

gacaaagaga cgctgtgatg atctgactcg aaggatgcgc agagatggtt ggccagctat     1440

gtgtatccat ggagacaaga gtcaaccaga aagagattgg gtacttaatg agttccgttc     1500

tggaaaggca cccatcctta ttgctacaga tgtagcctcc cgtgggctag atgtggaaga     1560

tgtcaagttt gtgatcaact atgactatcc aaacagctca gaggattatg tgcaccgtat     1620

tggccgaaca gcccgtagca ccaacaaggg taccgcctat accttcttca ccccagggaa     1680

cctaaaacag gccagagagc ttatcaaagt gctggaagag gccaatcagg ctatcaatcc     1740

aaaactgatg cagcttgtgg accacagagg aggcggcgga ggcgggggtg gtcgttctcg     1800

ttaccggacc acttcttcag ccaacaatcc caatctgatg tatcaggatg agtgtgaccg     1860

aaggcttcga ggagtcaagg atggtggccg gagagactct gcaagctatc gggatcgtag     1920

tgaaaccgat agagctggtt atgctaatgg cagtggctat ggaagtccaa attctgcctt     1980

tggagcacaa gcaggccaat acacctatgg tcaaggcacc tatggggcag ctgcttatgg     2040

caccagtagc tatacagctc aagaatatgg tgctggcact tatggagcta gtagcaccac     2100

ctcaactggg agaagttcac agagctctag ccagcagttt agtgggatag gccggtctgg     2160

gcagcagcca cagccactga tgtcacaaca gtttgcacag cctccgggag ctaccaatat     2220

gataggttac atggggcaga ctgcctacca ataccctcct cctcctcccc ctcctcctcc     2280

ttcacgtaaa tgaaaccact caagtggtag tgactccagc agacttaatt acattttaag     2340

gaacactgtc tttccttttt ttttcctctt cgccttttct ttttttttcc ttttttcttt     2400

tttttttttt aatttttccc cccaaccatc gtgatttgtc ttttcatgca gattagttag     2460

aattcactgc caggtttctt ctgcccacca aaatgatcca gtctggaata acattttgta     2520

aaaaaaaaaa aaatatatat atatatatat agctgactgg aagagattaa tttcttcccc     2580

caacttcttg catgttgaag atatttgagc tatttttcat ctaaaagagt aaggtattag     2640

gcccttttgt gggagcccca tgttttgttt ttctgagttg gtggggaggg agggaggggg     2700

agggctgaat tgttttgcag aggaagatgg catctgtgct ttaaatttct cattactggg     2760

ttagaaaaca aagagggatt gccctgcaca ttttcttttg tgcttttaaa tgtttcttaa     2820

gttggaacag gtttcctcgg gcctgttttg actgattgct ggagtgcatt tgatagttaa     2880

aaattactaa ttggttttat ttcccttcac actctgcctc cccacttctc cccccgttac     2940

tgaaaaataa ccattttagt gtcaggctag aaattgaatt gctgagtttt gtgtatcctt     3000

taaattaaaa accacaagtg tttattgtag tggttaaact gtagcatctc agcatctggg     3060

tggaagctgc ctatatttct tcccagttta actggggacc atctgtgaaa ttaattttcc     3120

atccagacag ctgctgtgag caaatgaaca taaatgctcg ctggaaattt actaaccagt     3180

ttttatattg acctgcagtg taaaaagcac atttaattat aaacaatata ttcaaaatgg     3240

gcaaatttta ttttcaaatg cagtgtagag ctagattaaa agcaactctt tgccacctac     3300

tctgcccttt tggcaaagtt accttgaaca aagaatctta agggtttatt aagaactctt     3360

tattttcttc ataccctgtt ctctgcagtg ctttctaaca gcttctgggt gcagattttc     3420

ttcggcatcc ttttgcactc agcttattac aggtaggtag tgcttaagaa aagtcatgga     3480

ggactaaagc ctaagtcctt ttcacttttc ctccatctga aggtaggtga gttcatcctc     3540

ttcatggtaa tgctgtttta ccaagacttt atagcagatg gacccagaaa gaattttctg     3600

ctattgtgtt cactacaaca ggatagggac atcagacagc cccagaaacc ccttccagat     3660

ctgatatggg actattaatt tttatgctgt taattggtat tcattcacaa tgcagttgaa     3720

gggggaaggc tccactgcat tctttggcta aggcctgaat gcttgctcat ctgtaagatc     3780

tatactcgag gttttgtttt ccttttaaaa ttctttaggg agagagggat ggtttctgag     3840

gggttctgaa agtatgattc aatgtgcaac atacaggtag gtcttcagca taagctgaaa     3900

tatatgcatg taaaaacttt gacatctttt tttttaattt tccactttct tcttaacttt     3960

acttctcttt ttgtcccccc cccatcttac agaagttgag gccaagggag aatggtaggc     4020

acagaagaaa catggcaaac tgctctgtgc tttcaaacca aagtgttccc cccaacccca     4080

aatttgtcta agcactggcc agtctgttgt gggcattgtt ttctacaacc aaattctggg     4140

tttttttctt ctttctttaa acatagaggt accaccacaa gggatgccct actctctcgc     4200

agctcttgaa agcatctgtt tgagggaaag gtctctgggc aagcaagtgg ttatttggat     4260

tgcttgcttc cctttttcca cctgggacat tgtaatcata aaataacagt aaattccaaa     4320

cctcaaaaac tattatggcc tgagcacagc tgaaatctag cagagtttaa ctcttctgcc     4380

tccatgtctg tcacttataa ttcaggttct gctgttggct tcagaacatg agcagaagaa     4440

tcgttttatg ctagttattg cattcatggt tgaaactcaa cttagggaaa gggttccaat     4500

gtattaagca atgggctgct tctccccaat cctccctaac aattcgttgt gtggacttct     4560

catctaaaag gttagtggct tttgcttggg atcagtgctc tctattgatg ttcttgctgg     4620

tctccagaca cattcctgtt gcattaagac ttgaaagact tgtagatgtg tgatgttcag     4680

gcacaggatg ctgaaagcta tgttactatt cttagtttgt aaattgtcct tttgatacca     4740

tcatcttgtt ttctttttgt aggtataaat aaaaacactg ttgacaataa aaaaaaaaaa     4800

aaaaa                                                                 4805


<210> 278
<211> 729
<212> PRT
<213> Homo sapiens

<400> 278
Met Pro Thr Gly Phe Val Ala Pro Ile Leu Cys Val Leu Leu Pro Ser 
1               5                   10                  15      


Pro Thr Arg Glu Ala Ala Thr Val Ala Ser Ala Thr Gly Asp Ser Ala 
            20                  25                  30          


Ser Glu Arg Glu Ser Ala Ala Pro Ala Ala Ala Pro Thr Ala Glu Ala 
        35                  40                  45              


Pro Pro Pro Ser Val Val Thr Arg Pro Glu Pro Gln Ala Leu Pro Ser 
    50                  55                  60                  


Pro Ala Ile Arg Ala Pro Leu Pro Asp Leu Tyr Pro Phe Gly Thr Met 
65                  70                  75                  80  


Arg Gly Gly Gly Phe Gly Asp Arg Asp Arg Asp Arg Asp Arg Gly Gly 
                85                  90                  95      


Phe Gly Ala Arg Gly Gly Gly Gly Leu Pro Pro Lys Lys Phe Gly Asn 
            100                 105                 110         


Pro Gly Glu Arg Leu Arg Lys Lys Lys Trp Asp Leu Ser Glu Leu Pro 
        115                 120                 125             


Lys Phe Glu Lys Asn Phe Tyr Val Glu His Pro Glu Val Ala Arg Leu 
    130                 135                 140                 


Thr Pro Tyr Glu Val Asp Glu Leu Arg Arg Lys Lys Glu Ile Thr Val 
145                 150                 155                 160 


Arg Gly Gly Asp Val Cys Pro Lys Pro Val Phe Ala Phe His His Ala 
                165                 170                 175     


Asn Phe Pro Gln Tyr Val Met Asp Val Leu Met Asp Gln His Phe Thr 
            180                 185                 190         


Glu Pro Thr Pro Ile Gln Cys Gln Gly Phe Pro Leu Ala Leu Ser Gly 
        195                 200                 205             


Arg Asp Met Val Gly Ile Ala Gln Thr Gly Ser Gly Lys Thr Leu Ala 
    210                 215                 220                 


Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro Tyr Leu Glu 
225                 230                 235                 240 


Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr Arg Glu Leu 
                245                 250                 255     


Ala Gln Gln Val Gln Gln Val Ala Asp Asp Tyr Gly Lys Cys Ser Arg 
            260                 265                 270         


Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly Pro Gln Ile 
        275                 280                 285             


Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr Pro Gly Arg 
    290                 295                 300                 


Leu Ile Asp Phe Leu Glu Ser Gly Lys Thr Asn Leu Arg Arg Cys Thr 
305                 310                 315                 320 


Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe Glu 
                325                 330                 335     


Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp Arg Gln Thr 
            340                 345                 350         


Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln Leu Ala Glu 
        355                 360                 365             


Asp Phe Leu Arg Asp Tyr Thr Gln Ile Asn Val Gly Asn Leu Glu Leu 
    370                 375                 380                 


Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys Met Glu Ser 
385                 390                 395                 400 


Glu Lys Asp His Lys Leu Ile Gln Leu Met Glu Glu Ile Met Ala Glu 
                405                 410                 415     


Lys Glu Asn Lys Thr Ile Ile Phe Val Glu Thr Lys Arg Arg Cys Asp 
            420                 425                 430         


Asp Leu Thr Arg Arg Met Arg Arg Asp Gly Trp Pro Ala Met Cys Ile 
        435                 440                 445             


His Gly Asp Lys Ser Gln Pro Glu Arg Asp Trp Val Leu Asn Glu Phe 
    450                 455                 460                 


Arg Ser Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val Ala Ser Arg 
465                 470                 475                 480 


Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr Pro 
                485                 490                 495     


Asn Ser Ser Glu Asp Tyr Val His Arg Ile Gly Arg Thr Ala Arg Ser 
            500                 505                 510         


Thr Asn Lys Gly Thr Ala Tyr Thr Phe Phe Thr Pro Gly Asn Leu Lys 
        515                 520                 525             


Gln Ala Arg Glu Leu Ile Lys Val Leu Glu Glu Ala Asn Gln Ala Ile 
    530                 535                 540                 


Asn Pro Lys Leu Met Gln Leu Val Asp His Arg Gly Gly Gly Gly Gly 
545                 550                 555                 560 


Gly Gly Gly Arg Ser Arg Tyr Arg Thr Thr Ser Ser Ala Asn Asn Pro 
                565                 570                 575     


Asn Leu Met Tyr Gln Asp Glu Cys Asp Arg Arg Leu Arg Gly Val Lys 
            580                 585                 590         


Asp Gly Gly Arg Arg Asp Ser Ala Ser Tyr Arg Asp Arg Ser Glu Thr 
        595                 600                 605             


Asp Arg Ala Gly Tyr Ala Asn Gly Ser Gly Tyr Gly Ser Pro Asn Ser 
    610                 615                 620                 


Ala Phe Gly Ala Gln Ala Gly Gln Tyr Thr Tyr Gly Gln Gly Thr Tyr 
625                 630                 635                 640 


Gly Ala Ala Ala Tyr Gly Thr Ser Ser Tyr Thr Ala Gln Glu Tyr Gly 
                645                 650                 655     


Ala Gly Thr Tyr Gly Ala Ser Ser Thr Thr Ser Thr Gly Arg Ser Ser 
            660                 665                 670         


Gln Ser Ser Ser Gln Gln Phe Ser Gly Ile Gly Arg Ser Gly Gln Gln 
        675                 680                 685             


Pro Gln Pro Leu Met Ser Gln Gln Phe Ala Gln Pro Pro Gly Ala Thr 
    690                 695                 700                 


Asn Met Ile Gly Tyr Met Gly Gln Thr Ala Tyr Gln Tyr Pro Pro Pro 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Pro Ser Arg Lys 
                725                 


<210> 279
<211> 2345
<212> DNA
<213> Homo sapiens

<400> 279
tggcgcgggc aatccctcaa cctgattggt cccctcgccc gtcactccag tgcgccccca       60

acctaccacg cagtaaaagc cacccccgcc tcggcccgga cggtttccaa gctggttttg      120

aagtcgcggc agctgttcct gggacgtccg gttgaccgcg cgtctgctgc agagaccatg      180

tctgccgacg gggcagaggc tgatggcagc acccaggtga cagtggaaga accggtacag      240

cagcccagtg tggtggaccg tgtggccagc atgcctctga tcagctccac ctgcgacatg      300

gtgtccgcag cctatgcctc caccaaggag agctacccgc acatcaagac tgtctgcgac      360

gcagcagaga agggagtgag gaccctcacg gcggctgctg tcagcggggc tcagccgatc      420

ctctccaagc tggagcccca gattgcatca gccagcgaat acgcccacag ggggctggac      480

aagttggagg agaacctccc catcctgcag cagcccacgg agaaggtcct ggcggacacc      540

aaggagcttg tgtcgtctaa ggtgtcgggg gcccaagaga tggtgtctag cgccaaggac      600

acggtggcca cccaattgtc ggaggcggtg gacgcgaccc gcggtgctgt gcagagcggc      660

gtggacaaga caaagtccgt agtgaccggc ggcgtccaat cggtcatggg ctcccgcttg      720

ggccagatgg tgttgagtgg ggtcgacacg gtgctgggga agtcggagga gtgggcggac      780

aaccacctgc cccttacgga tgccgaactg gcccgcatcg ccacatccct ggatggcttt      840

gacgtcgcgt ccgtgcagca gcagcggcag gaacagagct acttcgtacg tctgggctcc      900

ctgtcggaga ggctgcggca gcacgcctat gagcactcgc tgggcaagct tcgagccacc      960

aagcagaggg cacaggaggc tctgctgcag ctgtcgcagg tcctaagcct gatggaaact     1020

gtcaagcaag gcgttgatca gaagctggtg gaaggccagg agaagctgca ccagatgtgg     1080

ctcagctgga accagaagca gctccagggc cccgagaagg agccgcccaa gccagagcag     1140

gtcgagtccc gggcgctcac catgttccgg gacattgccc agcaactgca ggccacctgt     1200

acctccctgg ggtccagcat tcagggcctc cccaccaatg tgaaggacca ggtgcagcag     1260

gcccgccgcc aggtggagga cctccaggcc acgttttcca gcatccactc cttccaggac     1320

ctgtccagca gcattctggc ccagagccgt gagcgtgtcg ccagcgcccg cgaggccctg     1380

gaccacatgg tggaatatgt ggcccagaac acacctgtca cgtggctcgt gggacccttt     1440

gcccctggaa tcactgagaa agccccggag gagaagaagt agggggagag gagaggactc     1500

agcgggcccc gtctctataa tgcagctgtg ctctggagtc ctcaacccgg ggctcatttc     1560

aaacttattt tctagccact cctcccagct cttctgtgct gtccacttgg gaagctaagg     1620

ctctcaaaac gggcatcacc cagttgaccc atctctcagc ctctctgagc ttggaagaag     1680

cctgttctga gcctcaccct atcagtcagt agagagagat gtccagaaaa aatatctttc     1740

aggaaagttc tcccctgcag aatttttttt ccttgttaaa tatcaggaat ataggccggg     1800

tgcggtggct cacacctgta atcccagcac tttgggaggc tgaggcgggc ggaacacctg     1860

aggtcaggtg ttcgagacca gccaggccaa catggtgaaa ccccgtctct actaaaaata     1920

caaaaaaaaa tgagccgggc atggtagcag gtgtctgtta tcccagttag gaggctgagg     1980

caagagaatc tcttgaacct gagaggcgga ggttgcagtg agccaagatc gcgccattgc     2040

actccagcct gggggacaag agtgagactt agtctcaaaa aaaaaaaaaa agaaaaaaaa     2100

atcagggata tagttcatat cccacttctt tgtttacacc gatgtccctg aatatcagcc     2160

tgtagctaat ggacttggga tttctggtct aagtgggcct cctggggatg gggtggtaca     2220

ctgagcttct gagcctcatt gtagagtaga aaggtactgg ggcctgtgtg gtaagccttg     2280

ttgaaatgct ctggtattca gtattgcctt aataaacttc acccacaact gcatacaggc     2340

aaaaa                                                                 2345


<210> 280
<211> 434
<212> PRT
<213> Homo sapiens

<400> 280
Met Ser Ala Asp Gly Ala Glu Ala Asp Gly Ser Thr Gln Val Thr Val 
1               5                   10                  15      


Glu Glu Pro Val Gln Gln Pro Ser Val Val Asp Arg Val Ala Ser Met 
            20                  25                  30          


Pro Leu Ile Ser Ser Thr Cys Asp Met Val Ser Ala Ala Tyr Ala Ser 
        35                  40                  45              


Thr Lys Glu Ser Tyr Pro His Ile Lys Thr Val Cys Asp Ala Ala Glu 
    50                  55                  60                  


Lys Gly Val Arg Thr Leu Thr Ala Ala Ala Val Ser Gly Ala Gln Pro 
65                  70                  75                  80  


Ile Leu Ser Lys Leu Glu Pro Gln Ile Ala Ser Ala Ser Glu Tyr Ala 
                85                  90                  95      


His Arg Gly Leu Asp Lys Leu Glu Glu Asn Leu Pro Ile Leu Gln Gln 
            100                 105                 110         


Pro Thr Glu Lys Val Leu Ala Asp Thr Lys Glu Leu Val Ser Ser Lys 
        115                 120                 125             


Val Ser Gly Ala Gln Glu Met Val Ser Ser Ala Lys Asp Thr Val Ala 
    130                 135                 140                 


Thr Gln Leu Ser Glu Ala Val Asp Ala Thr Arg Gly Ala Val Gln Ser 
145                 150                 155                 160 


Gly Val Asp Lys Thr Lys Ser Val Val Thr Gly Gly Val Gln Ser Val 
                165                 170                 175     


Met Gly Ser Arg Leu Gly Gln Met Val Leu Ser Gly Val Asp Thr Val 
            180                 185                 190         


Leu Gly Lys Ser Glu Glu Trp Ala Asp Asn His Leu Pro Leu Thr Asp 
        195                 200                 205             


Ala Glu Leu Ala Arg Ile Ala Thr Ser Leu Asp Gly Phe Asp Val Ala 
    210                 215                 220                 


Ser Val Gln Gln Gln Arg Gln Glu Gln Ser Tyr Phe Val Arg Leu Gly 
225                 230                 235                 240 


Ser Leu Ser Glu Arg Leu Arg Gln His Ala Tyr Glu His Ser Leu Gly 
                245                 250                 255     


Lys Leu Arg Ala Thr Lys Gln Arg Ala Gln Glu Ala Leu Leu Gln Leu 
            260                 265                 270         


Ser Gln Val Leu Ser Leu Met Glu Thr Val Lys Gln Gly Val Asp Gln 
        275                 280                 285             


Lys Leu Val Glu Gly Gln Glu Lys Leu His Gln Met Trp Leu Ser Trp 
    290                 295                 300                 


Asn Gln Lys Gln Leu Gln Gly Pro Glu Lys Glu Pro Pro Lys Pro Glu 
305                 310                 315                 320 


Gln Val Glu Ser Arg Ala Leu Thr Met Phe Arg Asp Ile Ala Gln Gln 
                325                 330                 335     


Leu Gln Ala Thr Cys Thr Ser Leu Gly Ser Ser Ile Gln Gly Leu Pro 
            340                 345                 350         


Thr Asn Val Lys Asp Gln Val Gln Gln Ala Arg Arg Gln Val Glu Asp 
        355                 360                 365             


Leu Gln Ala Thr Phe Ser Ser Ile His Ser Phe Gln Asp Leu Ser Ser 
    370                 375                 380                 


Ser Ile Leu Ala Gln Ser Arg Glu Arg Val Ala Ser Ala Arg Glu Ala 
385                 390                 395                 400 


Leu Asp His Met Val Glu Tyr Val Ala Gln Asn Thr Pro Val Thr Trp 
                405                 410                 415     


Leu Val Gly Pro Phe Ala Pro Gly Ile Thr Glu Lys Ala Pro Glu Glu 
            420                 425                 430         


Lys Lys 
        


<210> 281
<211> 1734
<212> DNA
<213> Homo sapiens

<400> 281
acgcacgcac gtctctcgct ttcgcatact taaggcgtct gttctcggca gcggcacagc       60

gaggtcggca gcggcacagc gaggtcggca gcggcacagc gaggtcggca gcggcacagc      120

gaggtcggca gcggcagcga ggtcggcagc ggcacagcga ggtcggcagc ggcagcgagg      180

tcggcagcgg cgcgcgctgt gctcttccgc ggactctgaa tcatggcgac cacggccacg      240

atggcgacct cgggctcggc gcgaaagcgg ctgctcaaag aggaagacat gactaaagtg      300

gaattcgaga ccagcgagga ggtggatgtg acccccacgt tcgacaccat gggcctgcgg      360

gaggacctgc tgcggggcat ctacgcttac ggttttgaaa aaccatcagc aatccagcaa      420

cgagcaatca agcagatcat caaagggaga gatgtcatcg cacagtctca gtccggcaca      480

ggaaaaacag ccaccttcag tatctcagtc ctccagtgtt tggatattca ggttcgtgaa      540

actcaagctt tgatcttggc tcccacaaga gagttggctg tgcagatcca gaaggggctg      600

cttgctctcg gtgactacat gaatgtccag tgccatgcct gcattggagg caccaatgtt      660

ggcgaggaca tcaggaagct ggattacgga cagcatgttg tcgcgggcac tccagggcgt      720

gtttttgata tgattcgtcg cagaagccta aggacacgtg ctatcaaaat gttggttttg      780

gatgaagctg atgaaatgtt gaataaaggt ttcaaagagc agatttacga tgtatacagg      840

tacctgcctc cagccacaca ggtggttctc atcagtgcca cgctgccaca cgagattctg      900

gagatgacca acaagttcat gaccgaccca atccgcatct tggtgaaacg tgatgaattg      960

actctggaag gcatcaagca atttttcgtg gcagtggaga gggaagagtg gaaatttgac     1020

actctgtgtg acctctacga cacactgacc atcactcagg cggtcatctt ctgcaacacc     1080

aaaagaaagg tggactggct gacggagaaa atgagggaag ccaacttcac tgtatcctca     1140

atgcatggag acatgcccca gaaagagcgg gagtccatca tgaaggagtt ccggtcgggc     1200

gccagccgag tgcttatttc tacagatgtc tgggccaggg ggttggatgt ccctcaggtg     1260

tccctcatca ttaactatga tctccctaat aacagagaat tgtacataca cagaattggg     1320

agatcaggtc gatacggccg gaagggtgtg gccattaact ttgtaaagaa tgacgacatc     1380

cgcatcctca gagatatcga gcagtactat tccactcaga ttgatgagat gccgatgaac     1440

gttgctgatc ttatctgaag cagcagatca gtgggatgag ggagactgtt cacctgctgt     1500

gtactcctgt ttggaagtat ttagatccag attctactta atggggttta tatggacttt     1560

cttctcataa atggcctgcc gtctcccttc ctttgaagag gatatgggga ttctgctctc     1620

ttttcttatt tacatgtaaa taatacattg ttctaagtct ttttcattaa aaatttaaaa     1680

cttttcccat aaactctata cttctaaggt gccaccacct tctctagtaa ctta           1734


<210> 282
<211> 411
<212> PRT
<213> Homo sapiens

<400> 282
Met Ala Thr Thr Ala Thr Met Ala Thr Ser Gly Ser Ala Arg Lys Arg 
1               5                   10                  15      


Leu Leu Lys Glu Glu Asp Met Thr Lys Val Glu Phe Glu Thr Ser Glu 
            20                  25                  30          


Glu Val Asp Val Thr Pro Thr Phe Asp Thr Met Gly Leu Arg Glu Asp 
        35                  40                  45              


Leu Leu Arg Gly Ile Tyr Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile 
    50                  55                  60                  


Gln Gln Arg Ala Ile Lys Gln Ile Ile Lys Gly Arg Asp Val Ile Ala 
65                  70                  75                  80  


Gln Ser Gln Ser Gly Thr Gly Lys Thr Ala Thr Phe Ser Ile Ser Val 
                85                  90                  95      


Leu Gln Cys Leu Asp Ile Gln Val Arg Glu Thr Gln Ala Leu Ile Leu 
            100                 105                 110         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Gln Lys Gly Leu Leu Ala 
        115                 120                 125             


Leu Gly Asp Tyr Met Asn Val Gln Cys His Ala Cys Ile Gly Gly Thr 
    130                 135                 140                 


Asn Val Gly Glu Asp Ile Arg Lys Leu Asp Tyr Gly Gln His Val Val 
145                 150                 155                 160 


Ala Gly Thr Pro Gly Arg Val Phe Asp Met Ile Arg Arg Arg Ser Leu 
                165                 170                 175     


Arg Thr Arg Ala Ile Lys Met Leu Val Leu Asp Glu Ala Asp Glu Met 
            180                 185                 190         


Leu Asn Lys Gly Phe Lys Glu Gln Ile Tyr Asp Val Tyr Arg Tyr Leu 
        195                 200                 205             


Pro Pro Ala Thr Gln Val Val Leu Ile Ser Ala Thr Leu Pro His Glu 
    210                 215                 220                 


Ile Leu Glu Met Thr Asn Lys Phe Met Thr Asp Pro Ile Arg Ile Leu 
225                 230                 235                 240 


Val Lys Arg Asp Glu Leu Thr Leu Glu Gly Ile Lys Gln Phe Phe Val 
                245                 250                 255     


Ala Val Glu Arg Glu Glu Trp Lys Phe Asp Thr Leu Cys Asp Leu Tyr 
            260                 265                 270         


Asp Thr Leu Thr Ile Thr Gln Ala Val Ile Phe Cys Asn Thr Lys Arg 
        275                 280                 285             


Lys Val Asp Trp Leu Thr Glu Lys Met Arg Glu Ala Asn Phe Thr Val 
    290                 295                 300                 


Ser Ser Met His Gly Asp Met Pro Gln Lys Glu Arg Glu Ser Ile Met 
305                 310                 315                 320 


Lys Glu Phe Arg Ser Gly Ala Ser Arg Val Leu Ile Ser Thr Asp Val 
                325                 330                 335     


Trp Ala Arg Gly Leu Asp Val Pro Gln Val Ser Leu Ile Ile Asn Tyr 
            340                 345                 350         


Asp Leu Pro Asn Asn Arg Glu Leu Tyr Ile His Arg Ile Gly Arg Ser 
        355                 360                 365             


Gly Arg Tyr Gly Arg Lys Gly Val Ala Ile Asn Phe Val Lys Asn Asp 
    370                 375                 380                 


Asp Ile Arg Ile Leu Arg Asp Ile Glu Gln Tyr Tyr Ser Thr Gln Ile 
385                 390                 395                 400 


Asp Glu Met Pro Met Asn Val Ala Asp Leu Ile 
                405                 410     


<210> 283
<211> 7219
<212> DNA
<213> Homo sapiens

<400> 283
ggaccccggc aagcccgcgc acttggcagg agctgtagct accgccgtcc gcgcctccaa       60

ggtttcacgg cttcctcagc agagactcgg gctcgtccgc catgtccgcc gcagacgagg      120

ttgacgggct gggcgtggcc cggccgcact atggctctgt cctggataat gaaagactta      180

ctgcagagga gatggatgaa aggagacgtc agaacgtggc ttatgagtac ctttgtcatt      240

tggaagaagc gaagaggtgg atggaagcat gcctagggga agatctgcct cccaccacag      300

aactggagga ggggcttagg aatggggtct accttgccaa actggggaac ttcttctctc      360

ccaaagtagt gtccctgaaa aaaatctatg atcgagaaca gaccagatac aaggcgactg      420

gcctccactt tagacacact gataatgtga ttcagtggtt gaatgccatg gatgagattg      480

gattgcctaa gattttttac ccagaaacta cagatatcta tgatcgaaag aacatgccaa      540

gatgtatcta ctgtatccat gcactcagtt tgtacctgtt caagctaggc ctggcccctc      600

agattcaaga cctatatgga aaggttgact tcacagaaga agaaatcaac aacatgaaga      660

ctgagttgga gaagtatggc atccagatgc ctgcctttag caagattggg ggcatcttgg      720

ctaatgaact gtcagtggat gaagccgcat tacatgctgc tgttattgct attaatgaag      780

ctattgaccg tagaattcca gccgacacat ttgcagcttt gaaaaatccg aatgccatgc      840

ttgtaaatct tgaagagccc ttggcatcca cttaccagga tatactttac caggctaagc      900

aggacaaaat gacaaatgct aaaaacagga cagaaaactc agagagagaa agagatgttt      960

atgaggagct gctcacgcaa gctgaaattc aaggcaatat aaacaaagtc aatacatttt     1020

ctgcattagc aaatatcgac ctggctttag aacaaggaga tgcactggcc ttgttcaggg     1080

ctctgcagtc accagccctg gggcttcgag gactgcagca acagaatagc gactggtact     1140

tgaagcagct cctgagtgat aaacagcaga agagacagag tggtcagact gaccccctgc     1200

agaaggagga gctgcagtct ggagtggatg ctgcaaacag tgctgcccag caatatcaga     1260

gaagattggc agcagtagca ctgattaatg ctgcaatcca gaagggtgtt gctgagaaga     1320

ctgttttgga actgatgaat cccgaagccc agctgcccca ggtgtatcca tttgccgccg     1380

atctctatca gaaggagctg gctaccctgc agcgacaaag tcctgaacat aatctcaccc     1440

acccagagct ctctgtcgca gtggagatgt tgtcatcggt ggccctgatc aacagggcat     1500

tggaatcagg agatgtgaat acagtgtgga agcaattgag cagttcagtt actggtctta     1560

ccaatattga ggaagaaaac tgtcagaggt atctcgatga gttgatgaaa ctgaaggctc     1620

aggcacatgc agagaataat gaattcatta catggaatga tatccaagct tgcgtggacc     1680

atgtgaacct ggtggtgcaa gaggaacatg agaggatttt agccattggt ttaattaatg     1740

aagccctgga tgaaggtgat gcccaaaaga ctctgcaggc cctacagatt cctgcagcta     1800

aacttgaggg agtccttgca gaagtggccc agcattacca agacacgctg attagagcga     1860

agagagagaa agcccaggaa atccaggatg agtcagctgt gttatggttg gatgaaattc     1920

aaggtggaat ctggcagtcc aacaaagaca cccaagaagc acagaagttt gccttaggaa     1980

tctttgccat taatgaggca gtagaaagtg gtgatgttgg caaaacactg agtgcccttc     2040

gctcccctga tgttggcttg tatggagtca tccctgagtg tggtgaaact taccacagtg     2100

atcttgctga agccaagaag aaaaaactgg cagtaggaga taataacagc aagtgggtga     2160

agcactgggt aaaaggtgga tattattatt accacaatct ggagacccag gaaggaggat     2220

gggatgaacc tccaaatttt gtgcaaaatt ctatgcagct ttctcgggag gagatccaga     2280

gttctatctc tggggtgact gccgcatata accgagaaca gctgtggctg gccaatgaag     2340

gcctgatcac caggctgcag gctcgctgcc gtggatactt agttcgacag gaattccgat     2400

ccaggatgaa tttcctgaag aaacaaatcc ctgccatcac ctgcattcag tcacagtgga     2460

gaggatacaa gcagaagaag gcatatcaag atcggttagc ttacctgcgc tcccacaaag     2520

atgaagttgt aaagattcag tccctggcaa ggatgcacca agctcgaaag cgctatcgag     2580

atcgcctgca gtacttccgg gaccatataa atgacattat caaaatccag gcttttattc     2640

gggcaaacaa agctcgggat gactacaaga ctctcatcaa tgctgaggat cctcctatgg     2700

ttgtggtccg aaaatttgtc cacctgctgg accaaagtga ccaggatttt caggaggagc     2760

ttgaccttat gaagatgcgg gaagaggtta tcaccctcat tcgttctaac cagcagctgg     2820

agaatgacct caatctcatg gatatcaaaa ttggactgct agtgaaaaat aagattacgt     2880

tgcaggatgt ggtttcccac agtaaaaaac ttaccaaaaa aaataaggaa cagttgtctg     2940

atatgatgat gataaataaa cagaagggag gtctcaaggc tttgagcaag gagaagagag     3000

agaagttgga agcttaccag cacctgtttt atttattgca aaccaatccc acctatctgg     3060

ccaagctcat ttttcagatg ccccagaaca agtccaccaa gttcatggac tctgtaatct     3120

tcacactcta caactacgcg tccaaccagc gagaggagta cctgctcctg cggctcttta     3180

agacagcact ccaagaggaa atcaagtcga aggtagatca gattcaagag attgtgacag     3240

gaaatcctac ggttattaaa atggttgtaa gtttcaaccg tggtgcccgt ggccagaatg     3300

ccctgagaca gatcttggcc ccagtcgtga aggaaattat ggatgacaaa tctctcaaca     3360

tcaaaactga ccctgtggat atttacaaat cttgggttaa tcagatggag tctcagacag     3420

gagaggcaag caaactgccc tatgatgtga cccctgagca ggcgctagct catgaagaag     3480

tgaagacacg gctagacagc tccatcagga acatgcgggc tgtgacagac aagtttctct     3540

cagccattgt cagctctgtg gacaaaatcc cttatgggat gcgcttcatt gccaaagtgc     3600

tgaaggactc gttgcatgag aagttccctg atgctggtga ggatgagctg ctgaagatta     3660

ttggtaactt gctttattat cgatacatga atccagccat tgttgctcct gatgcctttg     3720

acatcattga cctgtcagca ggaggccagc ttaccacaga ccaacgccga aatctgggct     3780

ccattgcaaa aatgcttcag catgctgctt ccaataagat gtttctggga gataatgccc     3840

acttaagcat cattaatgaa tatctttccc agtcctacca gaaattcaga cggtttttcc     3900

aaactgcttg tgatgtccca gagcttcagg ataaatttaa tgtggatgag tactctgatt     3960

tagtaaccct caccaaacca gtaatctaca tttccattgg tgaaatcatc aacacccaca     4020

ctctcctgtt ggatcaccag gatgccattg ctccggagca caatgatcca atccacgaac     4080

tgctggacga cctcggcgag gtgcccacca tcgagtccct gataggggaa agctctggca     4140

atttaaatga cccaaataag gaggcactgg ctaagacgga agtgtctctc accctgacca     4200

acaagttcga cgtgcctgga gatgagaatg cagaaatgga tgctcgaacc atcttactga     4260

atacaaaacg tttaattgtg gatgtcatcc ggttccagcc aggagagacc ttgactgaaa     4320

tcctagaaac accagccacc agtgaacagg aagcagaaca tcagagagcc atgcagagac     4380

gtgctatccg tgatgccaaa acacctgaca agatgaaaaa gtcaaaatct gtaaaggaag     4440

acagcaacct cactcttcaa gagaagaaag agaagatcca gacaggttta aagaagctaa     4500

cagagcttgg aaccgtggac ccaaagaaca aataccagga actgatcaac gacattgcca     4560

gggatattcg gaatcagcgg aggtaccgac agaggagaaa ggccgaacta gtgaaactgc     4620

aacagacata cgctgctctg aactctaagg ccacctttta tggggagcag gtggattact     4680

ataaaagcta tatcaaaacc tgcttggata acttagccag caagggcaaa gtctccaaaa     4740

agcctaggga aatgaaagga aagaaaagca aaaagatttc tctgaaatat acagcagcaa     4800

gactacatga aaaaggagtt cttctggaaa ttgaggacct gcaagtgaat cagtttaaaa     4860

atgttatatt tgaaatcagt ccaacagaag aagttggaga cttcgaagtg aaagccaaat     4920

tcatgggagt tcaaatggag acttttatgt tacattatca ggacctgctg cagctacagt     4980

atgaaggagt tgcagtcatg aaattatttg atagagctaa agtaaatgtc aacctcctga     5040

tcttccttct caacaaaaag ttctacggga agtaattgat cgtttgctgc cagcccagaa     5100

ggatgaagga aagaagcacc tcacagctcc tttctaggtc cttctttcct cattggaagc     5160

aaagacctag ccaacaacag cacctcaatc tgatacactc ccgatgccac atttttaact     5220

cctctcgctc tgatgggaca tttgttaccc ttttttcata gtgaaattgt gtttcaggct     5280

tagtctgacc tttctggttt cttcattttc ttccattact taggaaagag tggaaactcc     5340

actaaaattt ctctgtgttg ttacagtctt agaggttgca gtactatatt gtaagctttg     5400

gtgtttgttt aattagcaat agggatggta ggattcaaat gtgtgtcatt tagaagtgga     5460

agctattagc accaatgaca taaatacata caagacacac aactaaaatg tcatgttatt     5520

aacagttatt aggttgtcat ttaaaaataa agttccttta tatttctgtc ccatcaggaa     5580

aactgaagga tatggggaat cattggttat cttccattgt gtttttcttt atggacagga     5640

gctaatggaa gtgacagtca tgttcaaagg aagcatttct agaaaaaagg agataatgtt     5700

tttaaatttc attatcaaac ttgggcaatt ctgtttgtgt aactccccga ctagtggatg     5760

ggagagtccc attgctaaaa ttcagctact cagataaatt cagaatgggt caaggcacct     5820

gcctgttttt gttggtgcac agagattgac ttgattcaga gagacaattc actccatccc     5880

tatggcagag gaatgggtta gccctaatgt agaatgtcat tgtttttaaa actgttttat     5940

atcttaagag tgccttatta aagtatagat gtatgtctta aaatgtgggt gataggaatt     6000

ttaaagattt atataatgca tcaaaagcct tagaataaga aaagcttttt ttaaattgct     6060

ttatctgtat atctgaactc ttgaaactta tagctaaaac actaggattt atctgcagtg     6120

ttcagggaga taattctgcc tttaattgtc taaaacaaaa acaaaaccag ccaacctatg     6180

ttacacgtga gattaaaacc aattttttcc ccattttttc tccttttttc tcttgctgcc     6240

cacattgtgc ctttatttta tgagccccag ttttctgggc ttagtttaaa aaaaaaatca     6300

agtctaaaca ttgcatttag aaagcttttg ttcttggata aaaagtcata cactttaaaa     6360

aaaaaaaaaa ctttttccag gaaaatatat tgaaatcatg ctgctgagcc tctattttct     6420

ttctttgatg ttttgattca gtattctttt atcataaatt tttagcattt aaaaattcac     6480

tgatgtacat taagccaata aactgcttta atgaataaca aactatgtag tgtgtcccta     6540

ttataaatgc attggagaag tatttttatg agactcttta ctcaggtgca tggttacagc     6600

ccacagggag gcatggagtg ccatggaagg attcgccact acccagacct tgttttttgt     6660

tgtattttgg aagacaggtt ttttaaagaa acattttcct cagattaaaa gatgatgcta     6720

ttacaactag cattgcctca aaaactggga ccaaccaaag tgtgtcaacc ctgtttcctt     6780

aaaagaggct atgaatccca aaggccacat ccaagacagg caataatgag cagagtttac     6840

agctccttta ataaaatgtg tcagtaattt taaggtttat agttccctca acacaattgc     6900

taatgcagaa tagtgtaaaa tgcgcttcaa gaatgttgat gatgatgata tagaattgtg     6960

gctttagtag cacagaggat gccccaacaa actcatggcg ttgaaaccac acagttctca     7020

ttactgttat ttattagctg tagcattctc tgtctcctct ctctcctcct ttgaccttct     7080

cctcgaccag ccatcatgac atttaccatg aatttacttc ctcccaagag tttggactgc     7140

ccgtcagatt gttgctgcac atagttgcct ttgtatctct gtatgaaata aaaggtcatt     7200

tgttcatgtt aaaaaaaaa                                                  7219


<210> 284
<211> 1657
<212> PRT
<213> Homo sapiens

<400> 284
Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His 
1               5                   10                  15      


Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp 
            20                  25                  30          


Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu 
        35                  40                  45              


Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys 
65                  70                  75                  80  


Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr 
                85                  90                  95      


Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His 
            100                 105                 110         


Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu 
        115                 120                 125             


Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn 
    130                 135                 140                 


Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe 
145                 150                 155                 160 


Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp 
                165                 170                 175     


Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr 
            180                 185                 190         


Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn 
        195                 200                 205             


Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile 
    210                 215                 220                 


Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu 
225                 230                 235                 240 


Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser 
                245                 250                 255     


Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn 
            260                 265                 270         


Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu 
        275                 280                 285             


Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn 
    290                 295                 300                 


Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp 
305                 310                 315                 320 


Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg 
                325                 330                 335     


Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser 
            340                 345                 350         


Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys 
        355                 360                 365             


Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln 
    370                 375                 380                 


Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln 
385                 390                 395                 400 


Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala 
                405                 410                 415     


Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu 
            420                 425                 430         


Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro 
        435                 440                 445             


Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn 
    450                 455                 460                 


Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser 
465                 470                 475                 480 


Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg 
                485                 490                 495     


Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn 
            500                 505                 510         


Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val 
        515                 520                 525             


Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu 
    530                 535                 540                 


Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala 
545                 550                 555                 560 


Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala 
                565                 570                 575     


Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln 
            580                 585                 590         


Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly 
        595                 600                 605             


Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala 
    610                 615                 620                 


Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly 
625                 630                 635                 640 


Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val 
                645                 650                 655     


Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys 
            660                 665                 670         


Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His 
        675                 680                 685             


Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu 
    690                 695                 700                 


Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu 
705                 710                 715                 720 


Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr 
                725                 730                 735     


Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu 
            740                 745                 750         


Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg 
        755                 760                 765             


Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser 
    770                 775                 780                 


Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala 
785                 790                 795                 800 


Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala 
                805                 810                 815     


Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe 
            820                 825                 830         


Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala 
        835                 840                 845             


Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro 
    850                 855                 860                 


Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp 
865                 870                 875                 880 


Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val 
                885                 890                 895     


Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu 
            900                 905                 910         


Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln 
        915                 920                 925             


Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln 
    930                 935                 940                 


Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala 
945                 950                 955                 960 


Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe 
                965                 970                 975     


Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln 
            980                 985                 990         


Met Pro Gln Asn Lys Ser Thr Lys  Phe Met Asp Ser Val  Ile Phe Thr 
        995                 1000                 1005             


Leu Tyr  Asn Tyr Ala Ser Asn  Gln Arg Glu Glu Tyr  Leu Leu Leu 
    1010                 1015                 1020             


Arg Leu  Phe Lys Thr Ala Leu  Gln Glu Glu Ile Lys  Ser Lys Val 
    1025                 1030                 1035             


Asp Gln  Ile Gln Glu Ile Val  Thr Gly Asn Pro Thr  Val Ile Lys 
    1040                 1045                 1050             


Met Val  Val Ser Phe Asn Arg  Gly Ala Arg Gly Gln  Asn Ala Leu 
    1055                 1060                 1065             


Arg Gln  Ile Leu Ala Pro Val  Val Lys Glu Ile Met  Asp Asp Lys 
    1070                 1075                 1080             


Ser Leu  Asn Ile Lys Thr Asp  Pro Val Asp Ile Tyr  Lys Ser Trp 
    1085                 1090                 1095             


Val Asn  Gln Met Glu Ser Gln  Thr Gly Glu Ala Ser  Lys Leu Pro 
    1100                 1105                 1110             


Tyr Asp  Val Thr Pro Glu Gln  Ala Leu Ala His Glu  Glu Val Lys 
    1115                 1120                 1125             


Thr Arg  Leu Asp Ser Ser Ile  Arg Asn Met Arg Ala  Val Thr Asp 
    1130                 1135                 1140             


Lys Phe  Leu Ser Ala Ile Val  Ser Ser Val Asp Lys  Ile Pro Tyr 
    1145                 1150                 1155             


Gly Met  Arg Phe Ile Ala Lys  Val Leu Lys Asp Ser  Leu His Glu 
    1160                 1165                 1170             


Lys Phe  Pro Asp Ala Gly Glu  Asp Glu Leu Leu Lys  Ile Ile Gly 
    1175                 1180                 1185             


Asn Leu  Leu Tyr Tyr Arg Tyr  Met Asn Pro Ala Ile  Val Ala Pro 
    1190                 1195                 1200             


Asp Ala  Phe Asp Ile Ile Asp  Leu Ser Ala Gly Gly  Gln Leu Thr 
    1205                 1210                 1215             


Thr Asp  Gln Arg Arg Asn Leu  Gly Ser Ile Ala Lys  Met Leu Gln 
    1220                 1225                 1230             


His Ala  Ala Ser Asn Lys Met  Phe Leu Gly Asp Asn  Ala His Leu 
    1235                 1240                 1245             


Ser Ile  Ile Asn Glu Tyr Leu  Ser Gln Ser Tyr Gln  Lys Phe Arg 
    1250                 1255                 1260             


Arg Phe  Phe Gln Thr Ala Cys  Asp Val Pro Glu Leu  Gln Asp Lys 
    1265                 1270                 1275             


Phe Asn  Val Asp Glu Tyr Ser  Asp Leu Val Thr Leu  Thr Lys Pro 
    1280                 1285                 1290             


Val Ile  Tyr Ile Ser Ile Gly  Glu Ile Ile Asn Thr  His Thr Leu 
    1295                 1300                 1305             


Leu Leu  Asp His Gln Asp Ala  Ile Ala Pro Glu His  Asn Asp Pro 
    1310                 1315                 1320             


Ile His  Glu Leu Leu Asp Asp  Leu Gly Glu Val Pro  Thr Ile Glu 
    1325                 1330                 1335             


Ser Leu  Ile Gly Glu Ser Ser  Gly Asn Leu Asn Asp  Pro Asn Lys 
    1340                 1345                 1350             


Glu Ala  Leu Ala Lys Thr Glu  Val Ser Leu Thr Leu  Thr Asn Lys 
    1355                 1360                 1365             


Phe Asp  Val Pro Gly Asp Glu  Asn Ala Glu Met Asp  Ala Arg Thr 
    1370                 1375                 1380             


Ile Leu  Leu Asn Thr Lys Arg  Leu Ile Val Asp Val  Ile Arg Phe 
    1385                 1390                 1395             


Gln Pro  Gly Glu Thr Leu Thr  Glu Ile Leu Glu Thr  Pro Ala Thr 
    1400                 1405                 1410             


Ser Glu  Gln Glu Ala Glu His  Gln Arg Ala Met Gln  Arg Arg Ala 
    1415                 1420                 1425             


Ile Arg  Asp Ala Lys Thr Pro  Asp Lys Met Lys Lys  Ser Lys Ser 
    1430                 1435                 1440             


Val Lys  Glu Asp Ser Asn Leu  Thr Leu Gln Glu Lys  Lys Glu Lys 
    1445                 1450                 1455             


Ile Gln  Thr Gly Leu Lys Lys  Leu Thr Glu Leu Gly  Thr Val Asp 
    1460                 1465                 1470             


Pro Lys  Asn Lys Tyr Gln Glu  Leu Ile Asn Asp Ile  Ala Arg Asp 
    1475                 1480                 1485             


Ile Arg  Asn Gln Arg Arg Tyr  Arg Gln Arg Arg Lys  Ala Glu Leu 
    1490                 1495                 1500             


Val Lys  Leu Gln Gln Thr Tyr  Ala Ala Leu Asn Ser  Lys Ala Thr 
    1505                 1510                 1515             


Phe Tyr  Gly Glu Gln Val Asp  Tyr Tyr Lys Ser Tyr  Ile Lys Thr 
    1520                 1525                 1530             


Cys Leu  Asp Asn Leu Ala Ser  Lys Gly Lys Val Ser  Lys Lys Pro 
    1535                 1540                 1545             


Arg Glu  Met Lys Gly Lys Lys  Ser Lys Lys Ile Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Thr Ala  Ala Arg Leu His Glu  Lys Gly Val Leu Leu  Glu Ile Glu 
    1565                 1570                 1575             


Asp Leu  Gln Val Asn Gln Phe  Lys Asn Val Ile Phe  Glu Ile Ser 
    1580                 1585                 1590             


Pro Thr  Glu Glu Val Gly Asp  Phe Glu Val Lys Ala  Lys Phe Met 
    1595                 1600                 1605             


Gly Val  Gln Met Glu Thr Phe  Met Leu His Tyr Gln  Asp Leu Leu 
    1610                 1615                 1620             


Gln Leu  Gln Tyr Glu Gly Val  Ala Val Met Lys Leu  Phe Asp Arg 
    1625                 1630                 1635             


Ala Lys  Val Asn Val Asn Leu  Leu Ile Phe Leu Leu  Asn Lys Lys 
    1640                 1645                 1650             


Phe Tyr  Gly Lys 
    1655         


<210> 285
<211> 3003
<212> DNA
<213> Homo sapiens

<400> 285
agaaggtttc atttccgggt ggcgcgggcg ccattttgtg aggagcgata taaacgggcg       60

cagaggccgg ctgcccgccc agttgttact caggtgcgct agcctgcgga gcccgtccgt      120

gctgttctgc ggcaaggcct ttcccagtgt ccccacgcgg aaggcaactg cctgagaggc      180

gcggcgtcgc accgcccaga gctgaggaag ccggcgccag ttcgcggggc tccgggccgc      240

cactcagagc tatgagctac ggccgccccc ctcccgatgt ggagggtatg acctccctca      300

aggtggacaa cctgacctac cgcacctcgc ccgacacgct gaggcgcgtc ttcgagaagt      360

acgggcgcgt cggcgacgtg tacatcccgc gggaccgcta caccaaggag tcccgcggct      420

tcgccttcgt tcgctttcac gacaagcgcg acgctgagga cgctatggat gccatggacg      480

gggccgtgct ggacggccgc gagctgcggg tgcaaatggc gcgctacggc cgccccccgg      540

actcacacca cagccgccgg ggaccgccac cccgcaggta cgggggcggt ggctacggac      600

gccggagccg cagccctagg cggcgtcgcc gcagccgatc ccggagtcgg agccgttcca      660

ggtctcgcag ccgatctcgc tacagccgct cgaagtctcg gtcccgcact cgttctcgat      720

ctcggtcgac ctccaagtcc agatccgcac gaaggtccaa gtccaagtcc tcgtcggtct      780

ccagatctcg ttcgcggtcc aggtcccggt ctcggtccag gagtcctccc ccagtgtcca      840

agagggaatc caaatccagg tcgcgatcga agagtccccc caagtctcct gaagaggaag      900

gagcggtgtc ctcttaagaa aatggtaatg tctgggaatc cgagacacat aaccctaatt      960

cataaatggg atttggggta ggtctttttg agtcgtgtta atgtaagaat gactcctatc     1020

attaggagtg ctgctcggag gttactcacc tttgggagta atactgaaga gaggggtctg     1080

cagaaaggat gtgtatgaag cttagataat aatggctgtt tcgtaaactg tttgagacct     1140

attaatgaaa atgactattt cttgctgttt ttatccaacg tctgcatttt ccccctttaa     1200

agctgcggtc tcctgtttga taaaagaata ttggccagta ttgcagattt taactgattt     1260

ggctgatcct ccagggacca gtttctgtgg gcgtgtattg gagcaggttt gtctttaaat     1320

gttaaagatg cactatcctc ttagagaaac aatcagttca actattgttg tactgactgg     1380

gacttcatat tctaatggat gtggcaaaag aattgcaata agaagcagtg aacatttgga     1440

accccaaaag aaagttacag gtattgcact gggtggggaa aggatagtgt gtctttaact     1500

cttaaattgt ttggtcctat tttttaaaaa ggaaagggcc ctaagtagct cagatattaa     1560

agtagtattc tcaattacca aatgtttcat ttgaaacaat ttatcttaat gaaatataga     1620

ccaattctct gatctcgagt tgtttttgtt tggatacagc cctttttttt ttcttttttt     1680

ttcttcccct tacctttctt caccttggtt atttggccag gaatacgtaa attcaaactt     1740

gtacatgctg atggtagcct ttgtgaaatt ttcctaattg ggccttttaa aaacatggct     1800

gggtggaaca tttctgtacc ctactggttt gaccagagcc ttagtaagta cgtgcctgaa     1860

actgaaacca tgtgcacttt aatggaaggt aagctgaact tctttctttt caaacctaga     1920

tgtatcggca agcagtgtaa acggaggact tggggaaaaa ggaccacata gtccatcgaa     1980

gaagagtcct tggaacaagc aactggctat tgaaaaggtt attttgtaac atttgtctaa     2040

ctttttactt gtttaagctt tgcctcagtt ggcaaacttc attttatgtg ccattttgtt     2100

gctgttattc aaatttcttg taatttagtg aggtgaacga cttcagattt cattattgga     2160

tttggatatt tgaggtaaaa tttcattttg ttatatagtg ctgacttttt ttgtttgaaa     2220

ttaaacagat tggtaaccta atttgtggcc tcctgacttt taaggaaaac gtgtgcagcc     2280

attacacaca gcctaaagct gtcaagagat tgactcggca ttgccttcat tccttaaaat     2340

taaaaaccta caaaagttgg tgtaaatttg tatatgttat ttaccttcag atctaaatgg     2400

taatctgaac ccaaatttgt ataaagactt ttcaggtgaa aagacttgat tttttgaaag     2460

gattgtttat caaacacaat tctaatctct tctcttatgt atttttgtgc actaggcgca     2520

gttgtgtagc agttgagtaa tgctggttag ctgttaaggt ggcgtgttgc agtgcagagt     2580

gcttggctgt ttcctgtttt ctcccgattg ctcctgtgta aagatgcctt gtcgtgcaga     2640

aacaaatggc tgtccagttt attaaaatgc ctgacaactg cacttccagt cacccgggcc     2700

ttgcatataa ataacggagc atacagtgag cacatctagc tgatgataaa tacacctttt     2760

tttccctctt ccccctaaaa atggtaaatc tgatcatatc tacatgtatg aacttaacat     2820

ggaaaatgtt aaggaagcaa atggttgtaa ctttgtaagt acttataaca tggtgtatct     2880

ttttgcttat gaatattctg tattataacc attgtttctg tagtttaatt aaaacatttt     2940

cttggtgtta gcttttctca gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3000

aaa                                                                   3003


<210> 286
<211> 221
<212> PRT
<213> Homo sapiens

<400> 286
Met Ser Tyr Gly Arg Pro Pro Pro Asp Val Glu Gly Met Thr Ser Leu 
1               5                   10                  15      


Lys Val Asp Asn Leu Thr Tyr Arg Thr Ser Pro Asp Thr Leu Arg Arg 
            20                  25                  30          


Val Phe Glu Lys Tyr Gly Arg Val Gly Asp Val Tyr Ile Pro Arg Asp 
        35                  40                  45              


Arg Tyr Thr Lys Glu Ser Arg Gly Phe Ala Phe Val Arg Phe His Asp 
    50                  55                  60                  


Lys Arg Asp Ala Glu Asp Ala Met Asp Ala Met Asp Gly Ala Val Leu 
65                  70                  75                  80  


Asp Gly Arg Glu Leu Arg Val Gln Met Ala Arg Tyr Gly Arg Pro Pro 
                85                  90                  95      


Asp Ser His His Ser Arg Arg Gly Pro Pro Pro Arg Arg Tyr Gly Gly 
            100                 105                 110         


Gly Gly Tyr Gly Arg Arg Ser Arg Ser Pro Arg Arg Arg Arg Arg Ser 
        115                 120                 125             


Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Tyr 
    130                 135                 140                 


Ser Arg Ser Lys Ser Arg Ser Arg Thr Arg Ser Arg Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Lys Ser Arg Ser Ala Arg Arg Ser Lys Ser Lys Ser Ser Ser Val 
                165                 170                 175     


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Pro 
            180                 185                 190         


Pro Pro Val Ser Lys Arg Glu Ser Lys Ser Arg Ser Arg Ser Lys Ser 
        195                 200                 205             


Pro Pro Lys Ser Pro Glu Glu Glu Gly Ala Val Ser Ser 
    210                 215                 220     


<210> 287
<211> 9252
<212> DNA
<213> Homo sapiens

<400> 287
ggcctgggcg cgtccctgca gcgtggcggg acggccccgt tccagtcacc cccgcctcgc       60

tgcggtggcc tcgggcctgg gcgcccgcct tcagctgcgg cggagctggc tctgtaaatg      120

ccggtgcccg cgagccctcc tgaatgcttg tctgcgcccg acgagcgcgg cctgtcccga      180

agctgtccac tgccaccact cgggcagtgc ttgctttagc ctggcccttt gcagctgaaa      240

ggcgtgacat ggtgtcgggt ggttcgtggg aagtcggggt ttcaggagtc cgtgtacttc      300

cttgtttgtc tttgtcgctg gccgacttgt cttcattcca ggtggccaga gcgagtgggg      360

ccgggcgttg tcacgggtat catgatatta gctggtttga catcaagtca tttgtgagtc      420

atcagatctt ctcctgaaaa tgggagacac agtagggccc ctcccaggag ctcttggctg      480

ttgctgatgg cagaagccaa gcttgtccaa ggttcacttg tagcccctca gcgtcagctc      540

agctggtgtc gtcctgacca tggacggcgc gtcggccgag caagatggcc tccaggagga      600

cagatcccac agtggcccct cgtctctccc cgaggcccca ctgaagcccc cgggcccact      660

ggtgccacct gaccagcagg acaaagtcca gtgtgccgag gtaaacagag catccacgga      720

aggggaaagc ccggatggac ctggccaggg aggcctctgt cagaacgggc caacgccacc      780

cttcccagac cctccgtcgt ctctcgatcc caccacaagc ccagtgggcc ctgatgcctc      840

tccaggtgtg gctggtttcc atgacaacct aaggaagtct cagggaacta gtgctgaggg      900

cagtgttaga aaagaagctt tgcagtctct cagactcagt cttcctatgc aagaaacgca      960

actgtgctct acagattctc ccctgcccct ggagaaggag gagcaggtcc gacttcaggc     1020

tcggaagtgg ctggaagagc agctcaaaca gtacagggtg aagcgccagc aggagaggtc     1080

cagtcaacct gcaaccaaaa cgagactttt tagcacgctt gatcctgagc tcatgttaaa     1140

cccagaaaac ttaccaaggg ccagtaccct ggctatgaca aaagaatatt ccttcctgcg     1200

caccagtgtc cctcgggggc ctaaggtggg cagcctgggg cttccggcac atcctaggga     1260

gaaaaaaact tccaaatcaa gcaaaatccg gtctctggcc gattacagaa ctgaagattc     1320

aaatgcgggg aattctgggg gaaatgtccc ggctcccgat tctaccaagg gttccctgaa     1380

gcagaacaga agcagtgcgg cgtccgttgt gtctgagatc agcctgtccc ccgacactga     1440

cgaccgtctg gagaacacct ccctggctgg agacagcgtg tctgaggtgg atggaaatga     1500

cagcgacagc tcatcgtaca gcagcgcctc cacccgaggg acctatggca ttctgtcgaa     1560

gacagtgggc acgcaggaca ccccctatat ggtcaacggc caggagattc ctgcggatac     1620

cctgggccag ttcccctcca ttaaggacgt cctccaggcc gcagccgctg agcaccaaga     1680

ccaggggcag gaggtcaacg gggaggtgcg gagtcggaga gacagcatct gcagcagcgt     1740

gtccttggag agctctgcag cagaaacaca ggaggagatg ctgcaggtgc tcaaagagaa     1800

aatgcgactc gaaggacagc tggaagcctt gtcactggag gcgagtcagg cacttaaaga     1860

gaaggctgag ctgcaggccc agctggccgc cctcagcacg aagctgcagg cgcaggtgga     1920

gtgcagccac agcagccagc agcggcagga ttcgctgagc tcggaggtgg acaccctgaa     1980

gcagtcgtgc tgggacctgg agcgagccat gactgacctg cagaacatgc tggaggcaaa     2040

aaatgccagc ctggcgtcgt ccaacaacga cttgcaggtg gccgaggagc agtaccagag     2100

gcttatggcc aaggtagagg acatgcagag gagcatgctc agcaaggaca acacagtgca     2160

cgacctgcga cagcagatga cagccttgca gagccagctt cagcaggtgc agctggagcg     2220

gacgacgctg accagcaagc tgaaggcgtc gcaggcggag atctcgtccc tgcagagtgt     2280

ccggcagtgg taccagcagc agctcgccct ggcacaggag gcccgcgtca ggctgcaggg     2340

tgagatggcc cacatccagg ttggacagat gacccaggca ggtctcctgg agcacctgaa     2400

actcgagaat gtgtccctgt cccagcagct gacggaaact cagcacaggt ccatgaagga     2460

gaaggggcgc atcgcggcac agctgcaggg cattgaggct gacatgttgg atcaggaagc     2520

agccttcatg cagattcagg aggcaaagac gatggtggag gaggaccttc agaggaggct     2580

ggaagagttt gaaggtgaga gggagcggct gcagaggatg gcggactcgg cggcatccct     2640

ggagcagcag ctggagcagg tgaagttgac tttactccag cgagaccagc agcttgaggc     2700

tttgcagcag gagcacctgg acctgatgaa acagctcacc ttgactcagg aggctctgca     2760

gagcagggag cagtccctcg atgccctgca gacacactac gatgagctgc aggccaggct     2820

gggggagctg cagggcgagg ccgcctccag ggaggacacg atctgcctcc tgcagaacga     2880

gaagatcatc ttggaggcgg ctttgcaggc ggccaagagt ggcaaggagg agcttgacag     2940

aggagcaaga cgcttggaag aaggtaccga ggaaacgtcg gaaactttag agaagttaag     3000

agaagaatta gctatcaaat ccggccaggt ggaacacctg cagcaggaga ctgctgctct     3060

gaaaaagcaa atgcaaaaaa taaaggaaca gtttctccaa caaaaggtga tggtggaggc     3120

ctaccggcgc gacgccacct ccaaagacca gctcatcagt gagctgaaag ccaccaggaa     3180

gaggctggac tcggagctga aggagctgcg gcaggagctg atgcaagtgc acggggagaa     3240

gcggactgcc gaggcggagc tctcgcgcct gcacagagag gtggcccagg tccgtcagca     3300

catggcggac cttgaagggc atctccagtc ggcgcagaag gagcgagacg agatggaaac     3360

acacttgcag tcgttgcagt tcgataagga gcagatggtc gcggtcacag aggccaatga     3420

ggcgctgaag aaacaaatcg aagagttgca gcaagaggcc cggaaggcca tcacggaaca     3480

gaagcagaag atgaggcggc tgggctcaga cttgaccagc gcccagaagg agatgaagac     3540

caaacataag gcctacgaga acgccgtggg catcctcagc cgccgcctgc aggaggccct     3600

cgcggccaag gaggctgcgg acgcggagct gggccagctc cgagcccagg gtggcagcag     3660

tgacagcagc ctggctctac atgaaaggat ccaggccctg gaggcggagc tgcaggctgt     3720

cagtcatagc aagacgctgc tggaaaagga actgcaggag gtcatagcgc tgaccagcca     3780

ggagctggag gagtcccggg agaaggtgct ggagctggag gacgagcttc aagaatccag     3840

aggctttagg aagaagataa aacgccttga ggagtcaaac aagaagttgg ctcttgaatt     3900

agagcacgag aaagggaagc ttacgggcct cggtcagtcc aacgcagctc tgcgggaaca     3960

caacagcatc ctagaaacag ctttggccaa gagggaggca gacctagtcc agttgaacct     4020

tcaggtgcag gcagttttgc agcgcaaaga agaggaggat cgccagatga agcatcttgt     4080

ccaggccctg caggcctcac tagagaagga gaaggagaag gtgaacagcc tcaaggagca     4140

ggtggctgct gccaaggtgg aagccgggca taaccgccgc cacttcaagg cggcctcctt     4200

ggagctgagt gaggtgaaga aggagctgca ggccaaggaa cacctggtgc agaagctgca     4260

ggccgaggcc gacgaccttc agattcggga ggggaaacat tcccaggaga tagcacagtt     4320

ccaagcagag ctggccgagg cccgggcaca gctccagctc ctgcagaagc agctggacga     4380

gcagctcagc aaacagcccg tgggaaacca agagatggaa aatctcaaat gggaggtgga     4440

tcagaaagaa agagaaatcc agtccttgaa gcagcagctg gacttgacgg agcagcaggg     4500

caggaaggaa ctggaagggc tacagcagct gctgcagaac gtcaagtctg agttggagat     4560

ggcccaggaa gacctgtcca tgacccagaa ggataaattt atgctccagg caaaagtgtc     4620

ggagctgaag aacaacatga agaccctgct ccagcagaac cagcagctca agctggacct     4680

acgccgcggc gcggccaaga cgagaaagga gccgaaaggc gaggccagct cttccaaccc     4740

tgccacgccc atcaagatcc cggactgccc agttcccgcc tcgctgctgg aggagctgct     4800

gagaccaccg cccgccgtga gcaaggagcc cctcaagaac ctgaacagct gcctccagca     4860

gctcaagcag gagatggaca gcctgcagcg ccagatggag gagcacgccc tgacggtgca     4920

cgagtctctg tcctcgtgga cgccgctgga gccagccact gccagccctg tgcccccggg     4980

gggtcacgcc ggcccacgcg gcgacccaca gagacacagt cagagcaggg cttccaaaga     5040

agggccggga gagtgactgc tgtggactcg cctccgtgcg ccgctgcccc agaaggctct     5100

tatcaatgtt atttatttga ttgtgtggtc gatgtttttc taagacatga aatttaagtt     5160

ttgttttgcc tttaacaaga agtaaaatat atagcagaat gagagccaag gactagaaaa     5220

acattcgaag atcacaatta gcttttcaca tggaatgacc aactcttaaa agcctgatag     5280

gctctcggcg aggagctttg aacgtgtctg aagggttact tgtaggtcgt ggcttctgag     5340

cggccaccga tgctgctctc tgcgggtgac agggagaggc tgcgtaactg ggagcagctg     5400

tgtgacaggg tctgcggcac cgcgcctggc caggccggct gcagtttctc acttccctgt     5460

tccattcagt aagagcttta cttttccgca gaaatgaaat tttatctgta cctttggctt     5520

tttacttgtt tttttggata gccatcccac cataggatgt gtacatagat actgaatatc     5580

ataatccaat ctttgttttt tttttttttt tttttttgag acagagtctc gctttgttgc     5640

ccaggctgga gtgcagtggc acactctccg ctcactgcaa gctccgcctc ccaggttcat     5700

gcgattctcc tgcctcagcc tctcgagtag ctgggattac aggcgtgcgc cactatgcca     5760

ggctaatgtt tgtattttta gtagcaatgg ggtttcacca tgttggccag gatggtctcg     5820

atctcctgac ctcaagtgat ctgcccatct cagcctccca aagtgctggg attacaggcg     5880

tgagcccctg cgcccggcct gtcacccagt ctttaagaag catatgctca tgttattgaa     5940

gaagaaccta cttattattg attgcctttt gaaaatttgt tgggaataat ttacctgcag     6000

gatttaggga tagtcagaaa attctaagaa atataattat tttatttacc ttctaaagcc     6060

aaatattctt acacagaaag gtcctctgtt gttctggttt tactttgttg ctgaggatct     6120

ttccttcctg ctggtctctt cctctcaggc cactggccct gtgtgattcc accgtggctg     6180

gccactggga aggggcagct tggacccttg gtcaggcctg acggccatca ggaggcacaa     6240

ggacactgag gccccatatc tgatctgacc tttggggggg cacagggaga ggccggtgga     6300

ggaggaggag gagagcagac caggggctcc ctgcagcgac tcccgcggtt tcccctggag     6360

tcagccaggt gtaggtcgca ggcggtaaca aacctcacac tcctgttccc caagtgaaaa     6420

tctttaccat tgtctgtggg agcgcctgta ctcgtgtgta ggagcacctg tacttctgca     6480

gtcatcgaga agtcctggat cttttgtggt tacaccagca tcatgtggca agcagaggcg     6540

acttccggaa gagacaggca ggcaccgtga ggaaggtggc tgtgctctcc caggtgtctc     6600

agagacagat gccttattta aaatcagcac gacatgtgtg agatcttctg tttcctaccc     6660

caaatcctga aaccctgcag acactggctg actgggagag gtggggtctg taagttgtcc     6720

cctagtttgc taagaaaatc taaaataata tttattatat gagttaggag agagagaatg     6780

ggtccgcgtg gcctcctctg cagatgtact ggtctgaaat gaggttctga gtcactggcc     6840

aggccagatg tgctcatgtc ggtgtctggt gtctgttttg tggagaaaac agtatggtgt     6900

gttttaagct atttgtgttc tgttgtaata tacttttaga aggttaattg gtaaggttaa     6960

ggtagcatta accacaaaga tgtttggtat ttaaaaaata ttctctagca aatattggaa     7020

tttccaaaat atatcatttg tacagggtta attttgaaat aatacttgaa aatttcatta     7080

taaatatatc ctacttttta tcttaagttg aagatgttat ttactaaatt gttcttgtac     7140

cattagaaaa aaaaatacgg caatttacgt tcttatttat tttggctgta ctaccccttt     7200

gttttaattt taaaatcaag aaatcgggcc gggcgcggtg gctcatgcct gtaatcccag     7260

cactttggga ggccgaggcg ggtggatcac ctgaggtcaa gaggtccaga ccatcctggc     7320

caacatggca aaaccccgtc tttactaaac atacaaaaat tagccgggtg tcgtagtgcg     7380

cacctataat cccagctact tgggaggctg aggcaggaga atcacttgaa cccaggaggc     7440

ggagcttgca gtgagccgag atcgcgccac tgccctccag cctgggcaac agagcgagac     7500

tccgtctcaa aaataaataa atgattttaa aaaatctaaa atcgagaaat cacacattca     7560

gtggggagcg acttctcctt gcttatggga agtcctcaag tgagtgatgt tcaccatgta     7620

tttttttttc tcttaggaca gactaattct gaaaataccg aaggaaaagt agctctatgt     7680

tctcaccccg gttttcctgc gtgtgtgccc ttgggtgcga tgcctccccc agcgctctgt     7740

ggtcgccggt gccagggccc cctctggttt ggcagggcct ggctgccttt gctccctgca     7800

gtgagtcttt tggtgttttc atgcacggct tgtgcttctg gatctgaggc ctctcgtgtt     7860

cacgcggaca cttccttcct taagaagacg cctaaaagag gaagttggaa tttttttttt     7920

ttttttttga gacagagtct cgctctgtcg cccaggctgg agtgcagtgg cgtgatctct     7980

gctcactgca agctccgcca tctgggttca agcgattctc ctgcctcatt ctccccagta     8040

gctgggatta caggtgcccg ccaccacacc agcctaattt ttgtattttt agaggggtgg     8100

agttccacca tgttggccag gctggtcttg aactcttgac ctcaggtgat cctgagcctc     8160

agcctcccaa agtgctggaa ttataggcgt gaaccaccgc ccccggctgc agttggattt     8220

ttaaattgct tttttttatt gttgaggttt ttttatctcc aagggactct cccggcactt     8280

ctaccttcca gagttacttc agtgcataaa gtttgaatta ttttgttctt gtgggcagaa     8340

gtgggaatga tggaatatcc tcacggaaaa ggcagtgaag ttgggagtac tgcttacaaa     8400

acagggtcac cagtgcatta tgtggcgtgt tcatccccac gccgtgtgtc acgggctagg     8460

gcggcgtgtt catccccaca ccgtgtgtca caacaggcta gggcacttca cgatgtcact     8520

acttgttttt ctgatgttcc aaaaacaacg taacttggtt ttcatgtgtt tttccgtggt     8580

atatgtgaga ttgatgctac gggtcttacg gactcacacc cgttcccact ctctgcaata     8640

tggatcaggc agtgtttctg ataggatgtg aaatggactc tcctcgggtg ggtccagcag     8700

gggccctgcc caccagaaca cagtccgtgc tgtgctgcgc taaggagctg gccctcaact     8760

ctccttggtg cagggttccc acaaccgagt tctagttccc tgaggtcttt aaaaacaaaa     8820

acagaatgtt gtacgtgaag attctaggag gggagggacc agcaaatctg agagaaccgt     8880

cctggggcct cccttcgagg agccctctga tgtgaggagg gacttgagtt gagtgacgct     8940

gtggtgtgag gtgttctgag ctcactgacc ggaaggtcca ggtgaatctc gtcataagtg     9000

atctcaggct ctcacaggat ccggagggaa atgtgttaga gggtctggaa aattcagtgc     9060

ttttgagtta cttgttttta ttaaaaattt cctcacaaaa gagagtcctc aagttgtggc     9120

tgttcttggg aaaggggtca ccgtgtctga caaagtgtaa ctttaaaaag cacgttgatt     9180

ttttacaaat gtaagtgtgc ttgggaattc cttaaatttt gtgcaataaa ctattttttg     9240

gtaaagattt tc                                                         9252


<210> 288
<211> 1498
<212> PRT
<213> Homo sapiens

<400> 288
Met Asp Gly Ala Ser Ala Glu Gln Asp Gly Leu Gln Glu Asp Arg Ser 
1               5                   10                  15      


His Ser Gly Pro Ser Ser Leu Pro Glu Ala Pro Leu Lys Pro Pro Gly 
            20                  25                  30          


Pro Leu Val Pro Pro Asp Gln Gln Asp Lys Val Gln Cys Ala Glu Val 
        35                  40                  45              


Asn Arg Ala Ser Thr Glu Gly Glu Ser Pro Asp Gly Pro Gly Gln Gly 
    50                  55                  60                  


Gly Leu Cys Gln Asn Gly Pro Thr Pro Pro Phe Pro Asp Pro Pro Ser 
65                  70                  75                  80  


Ser Leu Asp Pro Thr Thr Ser Pro Val Gly Pro Asp Ala Ser Pro Gly 
                85                  90                  95      


Val Ala Gly Phe His Asp Asn Leu Arg Lys Ser Gln Gly Thr Ser Ala 
            100                 105                 110         


Glu Gly Ser Val Arg Lys Glu Ala Leu Gln Ser Leu Arg Leu Ser Leu 
        115                 120                 125             


Pro Met Gln Glu Thr Gln Leu Cys Ser Thr Asp Ser Pro Leu Pro Leu 
    130                 135                 140                 


Glu Lys Glu Glu Gln Val Arg Leu Gln Ala Arg Lys Trp Leu Glu Glu 
145                 150                 155                 160 


Gln Leu Lys Gln Tyr Arg Val Lys Arg Gln Gln Glu Arg Ser Ser Gln 
                165                 170                 175     


Pro Ala Thr Lys Thr Arg Leu Phe Ser Thr Leu Asp Pro Glu Leu Met 
            180                 185                 190         


Leu Asn Pro Glu Asn Leu Pro Arg Ala Ser Thr Leu Ala Met Thr Lys 
        195                 200                 205             


Glu Tyr Ser Phe Leu Arg Thr Ser Val Pro Arg Gly Pro Lys Val Gly 
    210                 215                 220                 


Ser Leu Gly Leu Pro Ala His Pro Arg Glu Lys Lys Thr Ser Lys Ser 
225                 230                 235                 240 


Ser Lys Ile Arg Ser Leu Ala Asp Tyr Arg Thr Glu Asp Ser Asn Ala 
                245                 250                 255     


Gly Asn Ser Gly Gly Asn Val Pro Ala Pro Asp Ser Thr Lys Gly Ser 
            260                 265                 270         


Leu Lys Gln Asn Arg Ser Ser Ala Ala Ser Val Val Ser Glu Ile Ser 
        275                 280                 285             


Leu Ser Pro Asp Thr Asp Asp Arg Leu Glu Asn Thr Ser Leu Ala Gly 
    290                 295                 300                 


Asp Ser Val Ser Glu Val Asp Gly Asn Asp Ser Asp Ser Ser Ser Tyr 
305                 310                 315                 320 


Ser Ser Ala Ser Thr Arg Gly Thr Tyr Gly Ile Leu Ser Lys Thr Val 
                325                 330                 335     


Gly Thr Gln Asp Thr Pro Tyr Met Val Asn Gly Gln Glu Ile Pro Ala 
            340                 345                 350         


Asp Thr Leu Gly Gln Phe Pro Ser Ile Lys Asp Val Leu Gln Ala Ala 
        355                 360                 365             


Ala Ala Glu His Gln Asp Gln Gly Gln Glu Val Asn Gly Glu Val Arg 
    370                 375                 380                 


Ser Arg Arg Asp Ser Ile Cys Ser Ser Val Ser Leu Glu Ser Ser Ala 
385                 390                 395                 400 


Ala Glu Thr Gln Glu Glu Met Leu Gln Val Leu Lys Glu Lys Met Arg 
                405                 410                 415     


Leu Glu Gly Gln Leu Glu Ala Leu Ser Leu Glu Ala Ser Gln Ala Leu 
            420                 425                 430         


Lys Glu Lys Ala Glu Leu Gln Ala Gln Leu Ala Ala Leu Ser Thr Lys 
        435                 440                 445             


Leu Gln Ala Gln Val Glu Cys Ser His Ser Ser Gln Gln Arg Gln Asp 
    450                 455                 460                 


Ser Leu Ser Ser Glu Val Asp Thr Leu Lys Gln Ser Cys Trp Asp Leu 
465                 470                 475                 480 


Glu Arg Ala Met Thr Asp Leu Gln Asn Met Leu Glu Ala Lys Asn Ala 
                485                 490                 495     


Ser Leu Ala Ser Ser Asn Asn Asp Leu Gln Val Ala Glu Glu Gln Tyr 
            500                 505                 510         


Gln Arg Leu Met Ala Lys Val Glu Asp Met Gln Arg Ser Met Leu Ser 
        515                 520                 525             


Lys Asp Asn Thr Val His Asp Leu Arg Gln Gln Met Thr Ala Leu Gln 
    530                 535                 540                 


Ser Gln Leu Gln Gln Val Gln Leu Glu Arg Thr Thr Leu Thr Ser Lys 
545                 550                 555                 560 


Leu Lys Ala Ser Gln Ala Glu Ile Ser Ser Leu Gln Ser Val Arg Gln 
                565                 570                 575     


Trp Tyr Gln Gln Gln Leu Ala Leu Ala Gln Glu Ala Arg Val Arg Leu 
            580                 585                 590         


Gln Gly Glu Met Ala His Ile Gln Val Gly Gln Met Thr Gln Ala Gly 
        595                 600                 605             


Leu Leu Glu His Leu Lys Leu Glu Asn Val Ser Leu Ser Gln Gln Leu 
    610                 615                 620                 


Thr Glu Thr Gln His Arg Ser Met Lys Glu Lys Gly Arg Ile Ala Ala 
625                 630                 635                 640 


Gln Leu Gln Gly Ile Glu Ala Asp Met Leu Asp Gln Glu Ala Ala Phe 
                645                 650                 655     


Met Gln Ile Gln Glu Ala Lys Thr Met Val Glu Glu Asp Leu Gln Arg 
            660                 665                 670         


Arg Leu Glu Glu Phe Glu Gly Glu Arg Glu Arg Leu Gln Arg Met Ala 
        675                 680                 685             


Asp Ser Ala Ala Ser Leu Glu Gln Gln Leu Glu Gln Val Lys Leu Thr 
    690                 695                 700                 


Leu Leu Gln Arg Asp Gln Gln Leu Glu Ala Leu Gln Gln Glu His Leu 
705                 710                 715                 720 


Asp Leu Met Lys Gln Leu Thr Leu Thr Gln Glu Ala Leu Gln Ser Arg 
                725                 730                 735     


Glu Gln Ser Leu Asp Ala Leu Gln Thr His Tyr Asp Glu Leu Gln Ala 
            740                 745                 750         


Arg Leu Gly Glu Leu Gln Gly Glu Ala Ala Ser Arg Glu Asp Thr Ile 
        755                 760                 765             


Cys Leu Leu Gln Asn Glu Lys Ile Ile Leu Glu Ala Ala Leu Gln Ala 
    770                 775                 780                 


Ala Lys Ser Gly Lys Glu Glu Leu Asp Arg Gly Ala Arg Arg Leu Glu 
785                 790                 795                 800 


Glu Gly Thr Glu Glu Thr Ser Glu Thr Leu Glu Lys Leu Arg Glu Glu 
                805                 810                 815     


Leu Ala Ile Lys Ser Gly Gln Val Glu His Leu Gln Gln Glu Thr Ala 
            820                 825                 830         


Ala Leu Lys Lys Gln Met Gln Lys Ile Lys Glu Gln Phe Leu Gln Gln 
        835                 840                 845             


Lys Val Met Val Glu Ala Tyr Arg Arg Asp Ala Thr Ser Lys Asp Gln 
    850                 855                 860                 


Leu Ile Ser Glu Leu Lys Ala Thr Arg Lys Arg Leu Asp Ser Glu Leu 
865                 870                 875                 880 


Lys Glu Leu Arg Gln Glu Leu Met Gln Val His Gly Glu Lys Arg Thr 
                885                 890                 895     


Ala Glu Ala Glu Leu Ser Arg Leu His Arg Glu Val Ala Gln Val Arg 
            900                 905                 910         


Gln His Met Ala Asp Leu Glu Gly His Leu Gln Ser Ala Gln Lys Glu 
        915                 920                 925             


Arg Asp Glu Met Glu Thr His Leu Gln Ser Leu Gln Phe Asp Lys Glu 
    930                 935                 940                 


Gln Met Val Ala Val Thr Glu Ala Asn Glu Ala Leu Lys Lys Gln Ile 
945                 950                 955                 960 


Glu Glu Leu Gln Gln Glu Ala Arg Lys Ala Ile Thr Glu Gln Lys Gln 
                965                 970                 975     


Lys Met Arg Arg Leu Gly Ser Asp Leu Thr Ser Ala Gln Lys Glu Met 
            980                 985                 990         


Lys Thr Lys His Lys Ala Tyr Glu  Asn Ala Val Gly Ile  Leu Ser Arg 
        995                 1000                 1005             


Arg Leu  Gln Glu Ala Leu Ala  Ala Lys Glu Ala Ala  Asp Ala Glu 
    1010                 1015                 1020             


Leu Gly  Gln Leu Arg Ala Gln  Gly Gly Ser Ser Asp  Ser Ser Leu 
    1025                 1030                 1035             


Ala Leu  His Glu Arg Ile Gln  Ala Leu Glu Ala Glu  Leu Gln Ala 
    1040                 1045                 1050             


Val Ser  His Ser Lys Thr Leu  Leu Glu Lys Glu Leu  Gln Glu Val 
    1055                 1060                 1065             


Ile Ala  Leu Thr Ser Gln Glu  Leu Glu Glu Ser Arg  Glu Lys Val 
    1070                 1075                 1080             


Leu Glu  Leu Glu Asp Glu Leu  Gln Glu Ser Arg Gly  Phe Arg Lys 
    1085                 1090                 1095             


Lys Ile  Lys Arg Leu Glu Glu  Ser Asn Lys Lys Leu  Ala Leu Glu 
    1100                 1105                 1110             


Leu Glu  His Glu Lys Gly Lys  Leu Thr Gly Leu Gly  Gln Ser Asn 
    1115                 1120                 1125             


Ala Ala  Leu Arg Glu His Asn  Ser Ile Leu Glu Thr  Ala Leu Ala 
    1130                 1135                 1140             


Lys Arg  Glu Ala Asp Leu Val  Gln Leu Asn Leu Gln  Val Gln Ala 
    1145                 1150                 1155             


Val Leu  Gln Arg Lys Glu Glu  Glu Asp Arg Gln Met  Lys His Leu 
    1160                 1165                 1170             


Val Gln  Ala Leu Gln Ala Ser  Leu Glu Lys Glu Lys  Glu Lys Val 
    1175                 1180                 1185             


Asn Ser  Leu Lys Glu Gln Val  Ala Ala Ala Lys Val  Glu Ala Gly 
    1190                 1195                 1200             


His Asn  Arg Arg His Phe Lys  Ala Ala Ser Leu Glu  Leu Ser Glu 
    1205                 1210                 1215             


Val Lys  Lys Glu Leu Gln Ala  Lys Glu His Leu Val  Gln Lys Leu 
    1220                 1225                 1230             


Gln Ala  Glu Ala Asp Asp Leu  Gln Ile Arg Glu Gly  Lys His Ser 
    1235                 1240                 1245             


Gln Glu  Ile Ala Gln Phe Gln  Ala Glu Leu Ala Glu  Ala Arg Ala 
    1250                 1255                 1260             


Gln Leu  Gln Leu Leu Gln Lys  Gln Leu Asp Glu Gln  Leu Ser Lys 
    1265                 1270                 1275             


Gln Pro  Val Gly Asn Gln Glu  Met Glu Asn Leu Lys  Trp Glu Val 
    1280                 1285                 1290             


Asp Gln  Lys Glu Arg Glu Ile  Gln Ser Leu Lys Gln  Gln Leu Asp 
    1295                 1300                 1305             


Leu Thr  Glu Gln Gln Gly Arg  Lys Glu Leu Glu Gly  Leu Gln Gln 
    1310                 1315                 1320             


Leu Leu  Gln Asn Val Lys Ser  Glu Leu Glu Met Ala  Gln Glu Asp 
    1325                 1330                 1335             


Leu Ser  Met Thr Gln Lys Asp  Lys Phe Met Leu Gln  Ala Lys Val 
    1340                 1345                 1350             


Ser Glu  Leu Lys Asn Asn Met  Lys Thr Leu Leu Gln  Gln Asn Gln 
    1355                 1360                 1365             


Gln Leu  Lys Leu Asp Leu Arg  Arg Gly Ala Ala Lys  Thr Arg Lys 
    1370                 1375                 1380             


Glu Pro  Lys Gly Glu Ala Ser  Ser Ser Asn Pro Ala  Thr Pro Ile 
    1385                 1390                 1395             


Lys Ile  Pro Asp Cys Pro Val  Pro Ala Ser Leu Leu  Glu Glu Leu 
    1400                 1405                 1410             


Leu Arg  Pro Pro Pro Ala Val  Ser Lys Glu Pro Leu  Lys Asn Leu 
    1415                 1420                 1425             


Asn Ser  Cys Leu Gln Gln Leu  Lys Gln Glu Met Asp  Ser Leu Gln 
    1430                 1435                 1440             


Arg Gln  Met Glu Glu His Ala  Leu Thr Val His Glu  Ser Leu Ser 
    1445                 1450                 1455             


Ser Trp  Thr Pro Leu Glu Pro  Ala Thr Ala Ser Pro  Val Pro Pro 
    1460                 1465                 1470             


Gly Gly  His Ala Gly Pro Arg  Gly Asp Pro Gln Arg  His Ser Gln 
    1475                 1480                 1485             


Ser Arg  Ala Ser Lys Glu Gly  Pro Gly Glu 
    1490                 1495             


<210> 289
<211> 2596
<212> DNA
<213> Homo sapiens

<400> 289
gagcctcgaa gtccgccggc caatcgaagg cgggccccag cggcgcgtgc gcgccgcggc       60

cagcgcgcgc gggcgggggg gcaggcgcgc cccggaccca ggatttataa aggcgaggcc      120

gggaccggcg cgcgctctcg tcgcccccgc tgtcccggcg gcgccaaccg aagcgccccg      180

cctgatccgt gtccgacatg ctgcgccgcg ctctgctgtg cctggccgtg gccgccctgg      240

tgcgcgccga cgcccccgag gaggaggacc acgtcctggt gctgcggaaa agcaacttcg      300

cggaggcgct ggcggcccac aagtacctgc tggtggagtt ctatgcccct tggtgtggcc      360

actgcaaggc tctggcccct gagtatgcca aagccgctgg gaagctgaag gcagaaggtt      420

ccgagatcag gttggccaag gtggacgcca cggaggagtc tgacctggcc cagcagtacg      480

gcgtgcgcgg ctatcccacc atcaagttct tcaggaatgg agacacggct tcccccaagg      540

aatatacagc tggcagagag gctgatgaca tcgtgaactg gctgaagaag cgcacgggcc      600

cggctgccac caccctgcct gacggcgcag ctgcagagtc cttggtggag tccagcgagg      660

tggctgtcat cggcttcttc aaggacgtgg agtcggactc tgccaagcag tttttgcagg      720

cagcagaggc catcgatgac ataccatttg ggatcacttc caacagtgac gtgttctcca      780

aataccagct cgacaaagat ggggttgtcc tctttaagaa gtttgatgaa ggccggaaca      840

actttgaagg ggaggtcacc aaggagaacc tgctggactt tatcaaacac aaccagctgc      900

cccttgtcat cgagttcacc gagcagacag ccccgaagat ttttggaggt gaaatcaaga      960

ctcacatcct gctgttcttg cccaagagtg tgtctgacta tgacggcaaa ctgagcaact     1020

tcaaaacagc agccgagagc ttcaagggca agatcctgtt catcttcatc gacagcgacc     1080

acaccgacaa ccagcgcatc ctcgagttct ttggcctgaa gaaggaagag tgcccggccg     1140

tgcgcctcat caccctggag gaggagatga ccaagtacaa gcccgaatcg gaggagctga     1200

cggcagagag gatcacagag ttctgccacc gcttcctgga gggcaaaatc aagccccacc     1260

tgatgagcca ggagctgccg gaggactggg acaagcagcc tgtcaaggtg cttgttggga     1320

agaactttga agacgtggct tttgatgaga aaaaaaacgt ctttgtggag ttctatgccc     1380

catggtgtgg tcactgcaaa cagttggctc ccatttggga taaactggga gagacgtaca     1440

aggaccatga gaacatcgtc atcgccaaga tggactcgac tgccaacgag gtggaggccg     1500

tcaaagtgca cagcttcccc acactcaagt tctttcctgc cagtgccgac aggacggtca     1560

ttgattacaa cggggaacgc acgctggatg gttttaagaa attcctggag agcggtggcc     1620

aggatggggc aggggatgat gacgatctcg aggacctgga agaagcagag gagccagaca     1680

tggaggaaga cgatgatcag aaagctgtga aagatgaact gtaatacgca aagccagacc     1740

cgggcgctgc cgagacccct cgggggctgc acacccagca gcagcgcacg cctccgaagc     1800

ctgcggcctc gcttgaagga gggcgtcgcc ggaaacccag ggaacctctc tgaagtgaca     1860

cctcacccct acacaccgtc cgttcacccc cgtctcttcc ttctgctttt cggtttttgg     1920

aaagggatcc atctccaggc agcccaccct ggtggggctt gtttcctgaa accatgatgt     1980

actttttcat acatgagtct gtccagagtg cttgctaccg tgttcggagt ctcgctgcct     2040

ccctcccgcg ggaggtttct cctctttttg aaaattccgt ctgtgggatt tttagacatt     2100

tttcgacatc agggtatttg ttccaccttg gccaggcctc ctcggagaag cttgtccccc     2160

gtgtgggagg gacggagccg gactggacat ggtcactcag taccgcctgc agtgtcgcca     2220

tgactgatca tggctcttgc atttttgggt aaatggagac ttccggatcc tgtcagggtg     2280

tcccccatgc ctggaagagg agctggtggc tgccagccct ggggcccggc acaggcctgg     2340

gccttcccct tccctcaagc cagggctcct cctcctgtcg tgggctcatt gtgaccactg     2400

gcctctctac agcacggcct gtggcctgtt caaggcagaa ccacgaccct tgactcccgg     2460

gtggggaggt ggccaaggat gctggagctg aatcagacgc tgacagttct tcaggcattt     2520

ctatttcaca atcgaattga acacattggc caaataaagt tgaaatttta ccacctgtaa     2580

aaaaaaaaaa aaaaaa                                                     2596


<210> 290
<211> 508
<212> PRT
<213> Homo sapiens

<400> 290
Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210> 291
<211> 2445
<212> DNA
<213> Homo sapiens

<400> 291
ataaaagccc aggggcaagc ggtccggata acggctagcc tgaggagctg ctgcgacagt       60

ccactacctt tttcgagagt gactcccgtt gtcccaaggc ttcccagagc gaacctgtgc      120

ggctgcaggc accggcgcgt cgagtttccg gcgtccggaa ggaccgagct cttctcgcgg      180

atccagtgtt ccgtttccag cccccaatct cagagcggag ccgacagaga gcagggaacc      240

ggcatggcca aagccgcggc gatcggcatc gacctgggca ccacctactc ctgcgtgggg      300

gtgttccaac acggcaaggt ggagatcatc gccaacgacc agggcaaccg caccaccccc      360

agctacgtgg ccttcacgga caccgagcgg ctcatcgggg atgcggccaa gaaccaggtg      420

gcgctgaacc cgcagaacac cgtgtttgac gcgaagcggc tgattggccg caagttcggc      480

gacccggtgg tgcagtcgga catgaagcac tggcctttcc aggtgatcaa cgacggagac      540

aagcccaagg tgcaggtgag ctacaagggg gagaccaagg cattctaccc cgaggagatc      600

tcgtccatgg tgctgaccaa gatgaaggag atcgccgagg cgtacctggg ctacccggtg      660

accaacgcgg tgatcaccgt gccggcctac ttcaacgact cgcagcgcca ggccaccaag      720

gatgcgggtg tgatcgcggg gctcaacgtg ctgcggatca tcaacgagcc cacggccgcc      780

gccatcgcct acggcctgga cagaacgggc aagggggagc gcaacgtgct catctttgac      840

ctgggcgggg gcaccttcga cgtgtccatc ctgacgatcg acgacggcat cttcgaggtg      900

aaggccacgg ccggggacac ccacctgggt ggggaggact ttgacaacag gctggtgaac      960

cacttcgtgg aggagttcaa gagaaaacac aagaaggaca tcagccagaa caagcgagcc     1020

gtgaggcggc tgcgcaccgc ctgcgagagg gccaagagga ccctgtcgtc cagcacccag     1080

gccagcctgg agatcgactc cctgtttgag ggcatcgact tctacacgtc catcaccagg     1140

gcgaggttcg aggagctgtg ctccgacctg ttccgaagca ccctggagcc cgtggagaag     1200

gctctgcgcg acgccaagct ggacaaggcc cagattcacg acctggtcct ggtcgggggc     1260

tccacccgca tccccaaggt gcagaagctg ctgcaggact tcttcaacgg gcgcgacctg     1320

aacaagagca tcaaccccga cgaggctgtg gcctacgggg cggcggtgca ggcggccatc     1380

ctgatggggg acaagtccga gaacgtgcag gacctgctgc tgctggacgt ggctcccctg     1440

tcgctggggc tggagacggc cggaggcgtg atgactgccc tgatcaagcg caactccacc     1500

atccccacca agcagacgca gatcttcacc acctactccg acaaccaacc cggggtgctg     1560

atccaggtgt acgagggcga gagggccatg acgaaagaca acaatctgtt ggggcgcttc     1620

gagctgagcg gcatccctcc ggcccccagg ggcgtgcccc agatcgaggt gaccttcgac     1680

atcgatgcca acggcatcct gaacgtcacg gccacggaca agagcaccgg caaggccaac     1740

aagatcacca tcaccaacga caagggccgc ctgagcaagg aggagatcga gcgcatggtg     1800

caggaggcgg agaagtacaa agcggaggac gaggtgcagc gcgagagggt gtcagccaag     1860

aacgccctgg agtcctacgc cttcaacatg aagagcgccg tggaggatga ggggctcaag     1920

ggcaagatca gcgaggcgga caagaagaag gtgctggaca agtgtcaaga ggtcatctcg     1980

tggctggacg ccaacacctt ggccgagaag gacgagtttg agcacaagag gaaggagctg     2040

gagcaggtgt gtaaccccat catcagcgga ctgtaccagg gtgccggtgg tcccgggcct     2100

gggggcttcg gggctcaggg tcccaaggga gggtctgggt caggccccac cattgaggag     2160

gtagattagg ggcctttcca agattgctgt ttttgttttg gagcttcaag actttgcatt     2220

tcctagtatt tctgtttgtc agttctcaat ttcctgtgtt tgcaatgttg aaattttttg     2280

gtgaagtact gaacttgctt tttttccggt ttctacatgc agagatgaat ttatactgcc     2340

atcttacgac tatttcttct ttttaataca cttaactcag gccatttttt aagttggtta     2400

cttcaaagta aataaacttt aaaattcaaa aaaaaaaaaa aaaaa                     2445


<210> 292
<211> 641
<212> PRT
<213> Homo sapiens

<400> 292
Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210> 293
<211> 2053
<212> DNA
<213> Homo sapiens

<400> 293
cttccgtcgg ccattttagg tggtccgcgg cggcgccatt aaagcgagga ggaggcgaga       60

gcggccgccg ctggtgctta ttctttttta gtgcagcggg agagagcggg agtgtgcgcc      120

gcgcgagagt gggaggcgaa gggggcaggc cagggagagg cgcaggagcc tttgcagcca      180

cgcgcgcgcc ttccctgtct tgtgtgcttc gcgaggtaga gcgggcgcgc ggcagcggcg      240

gggattactt tgctgctagt ttcggttcgc ggcagcggcg ggtgtagtct cggcggcagc      300

ggcggagaca ctagcactat gtcggaggag cagttcggcg gggacggggc ggcggcagcg      360

gcaacggcgg cggtaggcgg ctcggcgggc gagcaggagg gagccatggt ggcggcgaca      420

cagggggcag cggcggcggc gggaagcgga gccgggaccg ggggcggaac cgcgtctgga      480

ggcaccgaag ggggcagcgc cgagtcggag ggggcgaaga ttgacgccag taagaacgag      540

gaggatgaag ggaaaatgtt tataggaggc cttagctggg acactacaaa gaaagatctg      600

aaggactact tttccaaatt tggtgaagtt gtagactgca ctctgaagtt agatcctatc      660

acagggcgat caaggggttt tggctttgtg ctatttaaag aatcggagag tgtagataag      720

gtcatggatc aaaaagaaca taaattgaat gggaaggtga ttgatcctaa aagggccaaa      780

gccatgaaaa caaaagagcc ggttaaaaaa atttttgttg gtggcctttc tccagataca      840

cctgaagaga aaataaggga gtactttggt ggttttggtg aggtggaatc catagagctc      900

cccatggaca acaagaccaa taagaggcgt gggttctgct ttattacctt taaggaagaa      960

gaaccagtga agaagataat ggaaaagaaa taccacaatg ttggtcttag taaatgtgaa     1020

ataaaagtag ccatgtcgaa ggaacaatat cagcaacagc aacagtgggg atctagagga     1080

ggatttgcag gaagagctcg tggaagaggt ggtgaccagc agagtggtta tgggaaggta     1140

tccaggcgag gtggtcatca aaatagctac aaaccatact aaattattcc atttgcaact     1200

tatccccaac aggtggtgaa gcagtatttt ccaatttgaa gattcatttg aaggtggctc     1260

ctgccacctg ctaatagcag ttcaaactaa attttttgta tcaagtccct gaatggaagt     1320

atgacgttgg gtccctctga agtttaattc tgagttctca ttaaaagaaa tttgctttca     1380

ttgttttatt tcttaattgc tatgcttcag aatcaatttg tgttttatgc cctttccccc     1440

agtattgtag agcaagtctt gtgttaaaag cccagtgtga cagtgtcatg atgtagtagt     1500

gtcttactgg ttttttaata aatccttttg tataaaaatg tattggctct tttatcatca     1560

gaataggaaa aattgtcatg gattcaagtt attaaaagca taagtttgga agacaggctt     1620

gccgaaattg aggacatgat taaaattgca gtgaagtttg aaatgttttt agcaaaatct     1680

aatttttgcc ataatgtgtc ctccctgtcc aaattgggaa tgacttaatg tcaatttgtt     1740

tgttggttgt tttaataata cttccttatg tagccattaa gatttatatg aatattttcc     1800

caaatgccca gtttttgctt aatatgtatt gtgcttttta gaacaaatct ggataaatgt     1860

gcaaaagtac ccctttgcac agatagttaa tgttttatgc ttccattaaa taaaaaggac     1920

ttaaaatctg ttaattataa tagaaatgcg gctagttcag agagattttt agagctgtgg     1980

tggacttcat agatgaattc aagtgttgag ggaggattaa agaaatatat accgtgttta     2040

tgtgtgtgtg ctt                                                        2053


<210> 294
<211> 287
<212> PRT
<213> Homo sapiens

<400> 294
Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly Lys Met 
65                  70                  75                  80  


Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp Leu Lys Asp 
                85                  90                  95      


Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu Lys Leu Asp 
            100                 105                 110         


Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu Phe Lys Glu 
        115                 120                 125             


Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His Lys Leu Asn 
    130                 135                 140                 


Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys Thr Lys Glu 
145                 150                 155                 160 


Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp Thr Pro Glu 
                165                 170                 175     


Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val Glu Ser Ile 
            180                 185                 190         


Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly Phe Cys Phe 
        195                 200                 205             


Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met Glu Lys Lys 
    210                 215                 220                 


Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val Ala Met Ser 
225                 230                 235                 240 


Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg Gly Gly Phe 
                245                 250                 255     


Ala Gly Arg Ala Arg Gly Arg Gly Gly Asp Gln Gln Ser Gly Tyr Gly 
            260                 265                 270         


Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr Lys Pro Tyr 
        275                 280                 285         


<210> 295
<211> 2110
<212> DNA
<213> Homo sapiens

<400> 295
cttccgtcgg ccattttagg tggtccgcgg cggcgccatt aaagcgagga ggaggcgaga       60

gcggccgccg ctggtgctta ttctttttta gtgcagcggg agagagcggg agtgtgcgcc      120

gcgcgagagt gggaggcgaa gggggcaggc cagggagagg cgcaggagcc tttgcagcca      180

cgcgcgcgcc ttccctgtct tgtgtgcttc gcgaggtaga gcgggcgcgc ggcagcggcg      240

gggattactt tgctgctagt ttcggttcgc ggcagcggcg ggtgtagtct cggcggcagc      300

ggcggagaca ctagcactat gtcggaggag cagttcggcg gggacggggc ggcggcagcg      360

gcaacggcgg cggtaggcgg ctcggcgggc gagcaggagg gagccatggt ggcggcgaca      420

cagggggcag cggcggcggc gggaagcgga gccgggaccg ggggcggaac cgcgtctgga      480

ggcaccgaag ggggcagcgc cgagtcggag ggggcgaaga ttgacgccag taagaacgag      540

gaggatgaag gccattcaaa ctcctcccca cgacactctg aagcagcgac ggcacagcgg      600

gaagaatgga aaatgtttat aggaggcctt agctgggaca ctacaaagaa agatctgaag      660

gactactttt ccaaatttgg tgaagttgta gactgcactc tgaagttaga tcctatcaca      720

gggcgatcaa ggggttttgg ctttgtgcta tttaaagaat cggagagtgt agataaggtc      780

atggatcaaa aagaacataa attgaatggg aaggtgattg atcctaaaag ggccaaagcc      840

atgaaaacaa aagagccggt taaaaaaatt tttgttggtg gcctttctcc agatacacct      900

gaagagaaaa taagggagta ctttggtggt tttggtgagg tggaatccat agagctcccc      960

atggacaaca agaccaataa gaggcgtggg ttctgcttta ttacctttaa ggaagaagaa     1020

ccagtgaaga agataatgga aaagaaatac cacaatgttg gtcttagtaa atgtgaaata     1080

aaagtagcca tgtcgaagga acaatatcag caacagcaac agtggggatc tagaggagga     1140

tttgcaggaa gagctcgtgg aagaggtggt gaccagcaga gtggttatgg gaaggtatcc     1200

aggcgaggtg gtcatcaaaa tagctacaaa ccatactaaa ttattccatt tgcaacttat     1260

ccccaacagg tggtgaagca gtattttcca atttgaagat tcatttgaag gtggctcctg     1320

ccacctgcta atagcagttc aaactaaatt ttttgtatca agtccctgaa tggaagtatg     1380

acgttgggtc cctctgaagt ttaattctga gttctcatta aaagaaattt gctttcattg     1440

ttttatttct taattgctat gcttcagaat caatttgtgt tttatgccct ttcccccagt     1500

attgtagagc aagtcttgtg ttaaaagccc agtgtgacag tgtcatgatg tagtagtgtc     1560

ttactggttt tttaataaat ccttttgtat aaaaatgtat tggctctttt atcatcagaa     1620

taggaaaaat tgtcatggat tcaagttatt aaaagcataa gtttggaaga caggcttgcc     1680

gaaattgagg acatgattaa aattgcagtg aagtttgaaa tgtttttagc aaaatctaat     1740

ttttgccata atgtgtcctc cctgtccaaa ttgggaatga cttaatgtca atttgtttgt     1800

tggttgtttt aataatactt ccttatgtag ccattaagat ttatatgaat attttcccaa     1860

atgcccagtt tttgcttaat atgtattgtg ctttttagaa caaatctgga taaatgtgca     1920

aaagtacccc tttgcacaga tagttaatgt tttatgcttc cattaaataa aaaggactta     1980

aaatctgtta attataatag aaatgcggct agttcagaga gatttttaga gctgtggtgg     2040

acttcataga tgaattcaag tgttgaggga ggattaaaga aatatatacc gtgtttatgt     2100

gtgtgtgctt                                                            2110


<210> 296
<211> 306
<212> PRT
<213> Homo sapiens

<400> 296
Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly His Ser 
65                  70                  75                  80  


Asn Ser Ser Pro Arg His Ser Glu Ala Ala Thr Ala Gln Arg Glu Glu 
                85                  90                  95      


Trp Lys Met Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp 
            100                 105                 110         


Leu Lys Asp Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu 
        115                 120                 125             


Lys Leu Asp Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu 
    130                 135                 140                 


Phe Lys Glu Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His 
145                 150                 155                 160 


Lys Leu Asn Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys 
                165                 170                 175     


Thr Lys Glu Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp 
            180                 185                 190         


Thr Pro Glu Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val 
        195                 200                 205             


Glu Ser Ile Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly 
    210                 215                 220                 


Phe Cys Phe Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met 
225                 230                 235                 240 


Glu Lys Lys Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val 
                245                 250                 255     


Ala Met Ser Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg 
            260                 265                 270         


Gly Gly Phe Ala Gly Arg Ala Arg Gly Arg Gly Gly Asp Gln Gln Ser 
        275                 280                 285             


Gly Tyr Gly Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr Lys 
    290                 295                 300                 


Pro Tyr 
305     


<210> 297
<211> 2200
<212> DNA
<213> Homo sapiens

<400> 297
cttccgtcgg ccattttagg tggtccgcgg cggcgccatt aaagcgagga ggaggcgaga       60

gcggccgccg ctggtgctta ttctttttta gtgcagcggg agagagcggg agtgtgcgcc      120

gcgcgagagt gggaggcgaa gggggcaggc cagggagagg cgcaggagcc tttgcagcca      180

cgcgcgcgcc ttccctgtct tgtgtgcttc gcgaggtaga gcgggcgcgc ggcagcggcg      240

gggattactt tgctgctagt ttcggttcgc ggcagcggcg ggtgtagtct cggcggcagc      300

ggcggagaca ctagcactat gtcggaggag cagttcggcg gggacggggc ggcggcagcg      360

gcaacggcgg cggtaggcgg ctcggcgggc gagcaggagg gagccatggt ggcggcgaca      420

cagggggcag cggcggcggc gggaagcgga gccgggaccg ggggcggaac cgcgtctgga      480

ggcaccgaag ggggcagcgc cgagtcggag ggggcgaaga ttgacgccag taagaacgag      540

gaggatgaag ggaaaatgtt tataggaggc cttagctggg acactacaaa gaaagatctg      600

aaggactact tttccaaatt tggtgaagtt gtagactgca ctctgaagtt agatcctatc      660

acagggcgat caaggggttt tggctttgtg ctatttaaag aatcggagag tgtagataag      720

gtcatggatc aaaaagaaca taaattgaat gggaaggtga ttgatcctaa aagggccaaa      780

gccatgaaaa caaaagagcc ggttaaaaaa atttttgttg gtggcctttc tccagataca      840

cctgaagaga aaataaggga gtactttggt ggttttggtg aggtggaatc catagagctc      900

cccatggaca acaagaccaa taagaggcgt gggttctgct ttattacctt taaggaagaa      960

gaaccagtga agaagataat ggaaaagaaa taccacaatg ttggtcttag taaatgtgaa     1020

ataaaagtag ccatgtcgaa ggaacaatat cagcaacagc aacagtgggg atctagagga     1080

ggatttgcag gaagagctcg tggaagaggt ggtggcccca gtcaaaactg gaaccaggga     1140

tatagtaact attggaatca aggctatggc aactatggat ataacagcca aggttacggt     1200

ggttatggag gatatgacta cactggttac aacaactact atggatatgg tgattatagc     1260

aaccagcaga gtggttatgg gaaggtatcc aggcgaggtg gtcatcaaaa tagctacaaa     1320

ccatactaaa ttattccatt tgcaacttat ccccaacagg tggtgaagca gtattttcca     1380

atttgaagat tcatttgaag gtggctcctg ccacctgcta atagcagttc aaactaaatt     1440

ttttgtatca agtccctgaa tggaagtatg acgttgggtc cctctgaagt ttaattctga     1500

gttctcatta aaagaaattt gctttcattg ttttatttct taattgctat gcttcagaat     1560

caatttgtgt tttatgccct ttcccccagt attgtagagc aagtcttgtg ttaaaagccc     1620

agtgtgacag tgtcatgatg tagtagtgtc ttactggttt tttaataaat ccttttgtat     1680

aaaaatgtat tggctctttt atcatcagaa taggaaaaat tgtcatggat tcaagttatt     1740

aaaagcataa gtttggaaga caggcttgcc gaaattgagg acatgattaa aattgcagtg     1800

aagtttgaaa tgtttttagc aaaatctaat ttttgccata atgtgtcctc cctgtccaaa     1860

ttgggaatga cttaatgtca atttgtttgt tggttgtttt aataatactt ccttatgtag     1920

ccattaagat ttatatgaat attttcccaa atgcccagtt tttgcttaat atgtattgtg     1980

ctttttagaa caaatctgga taaatgtgca aaagtacccc tttgcacaga tagttaatgt     2040

tttatgcttc cattaaataa aaaggactta aaatctgtta attataatag aaatgcggct     2100

agttcagaga gatttttaga gctgtggtgg acttcataga tgaattcaag tgttgaggga     2160

ggattaaaga aatatatacc gtgtttatgt gtgtgtgctt                           2200


<210> 298
<211> 336
<212> PRT
<213> Homo sapiens

<400> 298
Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly Lys Met 
65                  70                  75                  80  


Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp Leu Lys Asp 
                85                  90                  95      


Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu Lys Leu Asp 
            100                 105                 110         


Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu Phe Lys Glu 
        115                 120                 125             


Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His Lys Leu Asn 
    130                 135                 140                 


Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys Thr Lys Glu 
145                 150                 155                 160 


Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp Thr Pro Glu 
                165                 170                 175     


Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val Glu Ser Ile 
            180                 185                 190         


Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly Phe Cys Phe 
        195                 200                 205             


Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met Glu Lys Lys 
    210                 215                 220                 


Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val Ala Met Ser 
225                 230                 235                 240 


Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg Gly Gly Phe 
                245                 250                 255     


Ala Gly Arg Ala Arg Gly Arg Gly Gly Gly Pro Ser Gln Asn Trp Asn 
            260                 265                 270         


Gln Gly Tyr Ser Asn Tyr Trp Asn Gln Gly Tyr Gly Asn Tyr Gly Tyr 
        275                 280                 285             


Asn Ser Gln Gly Tyr Gly Gly Tyr Gly Gly Tyr Asp Tyr Thr Gly Tyr 
    290                 295                 300                 


Asn Asn Tyr Tyr Gly Tyr Gly Asp Tyr Ser Asn Gln Gln Ser Gly Tyr 
305                 310                 315                 320 


Gly Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr Lys Pro Tyr 
                325                 330                 335     


<210> 299
<211> 2257
<212> DNA
<213> Homo sapiens

<400> 299
cttccgtcgg ccattttagg tggtccgcgg cggcgccatt aaagcgagga ggaggcgaga       60

gcggccgccg ctggtgctta ttctttttta gtgcagcggg agagagcggg agtgtgcgcc      120

gcgcgagagt gggaggcgaa gggggcaggc cagggagagg cgcaggagcc tttgcagcca      180

cgcgcgcgcc ttccctgtct tgtgtgcttc gcgaggtaga gcgggcgcgc ggcagcggcg      240

gggattactt tgctgctagt ttcggttcgc ggcagcggcg ggtgtagtct cggcggcagc      300

ggcggagaca ctagcactat gtcggaggag cagttcggcg gggacggggc ggcggcagcg      360

gcaacggcgg cggtaggcgg ctcggcgggc gagcaggagg gagccatggt ggcggcgaca      420

cagggggcag cggcggcggc gggaagcgga gccgggaccg ggggcggaac cgcgtctgga      480

ggcaccgaag ggggcagcgc cgagtcggag ggggcgaaga ttgacgccag taagaacgag      540

gaggatgaag gccattcaaa ctcctcccca cgacactctg aagcagcgac ggcacagcgg      600

gaagaatgga aaatgtttat aggaggcctt agctgggaca ctacaaagaa agatctgaag      660

gactactttt ccaaatttgg tgaagttgta gactgcactc tgaagttaga tcctatcaca      720

gggcgatcaa ggggttttgg ctttgtgcta tttaaagaat cggagagtgt agataaggtc      780

atggatcaaa aagaacataa attgaatggg aaggtgattg atcctaaaag ggccaaagcc      840

atgaaaacaa aagagccggt taaaaaaatt tttgttggtg gcctttctcc agatacacct      900

gaagagaaaa taagggagta ctttggtggt tttggtgagg tggaatccat agagctcccc      960

atggacaaca agaccaataa gaggcgtggg ttctgcttta ttacctttaa ggaagaagaa     1020

ccagtgaaga agataatgga aaagaaatac cacaatgttg gtcttagtaa atgtgaaata     1080

aaagtagcca tgtcgaagga acaatatcag caacagcaac agtggggatc tagaggagga     1140

tttgcaggaa gagctcgtgg aagaggtggt ggccccagtc aaaactggaa ccagggatat     1200

agtaactatt ggaatcaagg ctatggcaac tatggatata acagccaagg ttacggtggt     1260

tatggaggat atgactacac tggttacaac aactactatg gatatggtga ttatagcaac     1320

cagcagagtg gttatgggaa ggtatccagg cgaggtggtc atcaaaatag ctacaaacca     1380

tactaaatta ttccatttgc aacttatccc caacaggtgg tgaagcagta ttttccaatt     1440

tgaagattca tttgaaggtg gctcctgcca cctgctaata gcagttcaaa ctaaattttt     1500

tgtatcaagt ccctgaatgg aagtatgacg ttgggtccct ctgaagttta attctgagtt     1560

ctcattaaaa gaaatttgct ttcattgttt tatttcttaa ttgctatgct tcagaatcaa     1620

tttgtgtttt atgccctttc ccccagtatt gtagagcaag tcttgtgtta aaagcccagt     1680

gtgacagtgt catgatgtag tagtgtctta ctggtttttt aataaatcct tttgtataaa     1740

aatgtattgg ctcttttatc atcagaatag gaaaaattgt catggattca agttattaaa     1800

agcataagtt tggaagacag gcttgccgaa attgaggaca tgattaaaat tgcagtgaag     1860

tttgaaatgt ttttagcaaa atctaatttt tgccataatg tgtcctccct gtccaaattg     1920

ggaatgactt aatgtcaatt tgtttgttgg ttgttttaat aatacttcct tatgtagcca     1980

ttaagattta tatgaatatt ttcccaaatg cccagttttt gcttaatatg tattgtgctt     2040

tttagaacaa atctggataa atgtgcaaaa gtaccccttt gcacagatag ttaatgtttt     2100

atgcttccat taaataaaaa ggacttaaaa tctgttaatt ataatagaaa tgcggctagt     2160

tcagagagat ttttagagct gtggtggact tcatagatga attcaagtgt tgagggagga     2220

ttaaagaaat atataccgtg tttatgtgtg tgtgctt                              2257


<210> 300
<211> 355
<212> PRT
<213> Homo sapiens

<400> 300
Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly His Ser 
65                  70                  75                  80  


Asn Ser Ser Pro Arg His Ser Glu Ala Ala Thr Ala Gln Arg Glu Glu 
                85                  90                  95      


Trp Lys Met Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp 
            100                 105                 110         


Leu Lys Asp Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu 
        115                 120                 125             


Lys Leu Asp Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu 
    130                 135                 140                 


Phe Lys Glu Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His 
145                 150                 155                 160 


Lys Leu Asn Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys 
                165                 170                 175     


Thr Lys Glu Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp 
            180                 185                 190         


Thr Pro Glu Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val 
        195                 200                 205             


Glu Ser Ile Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly 
    210                 215                 220                 


Phe Cys Phe Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met 
225                 230                 235                 240 


Glu Lys Lys Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val 
                245                 250                 255     


Ala Met Ser Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg 
            260                 265                 270         


Gly Gly Phe Ala Gly Arg Ala Arg Gly Arg Gly Gly Gly Pro Ser Gln 
        275                 280                 285             


Asn Trp Asn Gln Gly Tyr Ser Asn Tyr Trp Asn Gln Gly Tyr Gly Asn 
    290                 295                 300                 


Tyr Gly Tyr Asn Ser Gln Gly Tyr Gly Gly Tyr Gly Gly Tyr Asp Tyr 
305                 310                 315                 320 


Thr Gly Tyr Asn Asn Tyr Tyr Gly Tyr Gly Asp Tyr Ser Asn Gln Gln 
                325                 330                 335     


Ser Gly Tyr Gly Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr 
            340                 345                 350         


Lys Pro Tyr 
        355 


<210> 301
<211> 1668
<212> DNA
<213> Homo sapiens

<400> 301
aggggttacg acccatcagc ccttgcgcgc caccgtccct tctctcttcc tcggcgctgc       60

ctacggaggt ggcagccatc tccttctcgg catcatggcc gccctcagac cccttgtgaa      120

gcccaagatc gtcaaaaaga gaaccaagaa gttcatccgg caccagtcag accgatatgt      180

caaaattaag cgtaactggc ggaaacccag aggcattgac aacagggttc gtagaagatt      240

caagggccag atcttgatgc ccaacattgg ttatggaagc aacaaaaaaa caaagcacat      300

gctgcccagt ggcttccgga agttcctggt ccacaacgtc aaggagctgg aagtgctgct      360

gatgtgcaac aaatcttact gtgccgagat cgctcacaat gtttcctcca agaaccgcaa      420

agccatcgtg gaaagagctg cccaactggc catcagagtc accaacccca atgccaggct      480

gcgcagtgaa gaaaatgagt aggcagctca tgtgcacgtt ttctgtttaa ataaatgtaa      540

aaactgccat ctggcatctt ccttccttga ttttaagtct tcagcttctt ggccaactta      600

gtttgccaca gagattgttc ttttgcttaa gcccctttgg aatctcccat ttggagggga      660

tttgtaaagg acactcagtc cttgaacagg ggaatgtggc ctcaagtgca cagactagcc      720

ttagtcatct ccagttgagg ctgggtatga ggggtacaga cttggccctc acaccaggta      780

ggttctgaga cacttgaaga agcttgtggc tcccaagcca caagtagtca ttcttagcct      840

tgcttttgta aagttaggtg acaagttatt ccatgtgatg cttgtgagaa ttgagaaaat      900

atgcatggaa atatccagat gaatttctta cacagattct tacgggatgc ctaaattgca      960

tcctgtaact tctgtccaaa aagaacagga tgatgtacaa attgctcttc caggtaatcc     1020

accacggtta actggaaaag cactttcagt ctcctataac cctcccacca gctgctgctt     1080

caggtataat gttacagcag tttgccaagg cggggaccta actggtgaca attgagcctc     1140

ttgactggta ctcagaattt agtgacacgt ggtcctgatt ttttttggag acggggtctt     1200

gctctcaccc aggctgggag tgcagtggca cactgactac agccttgacc tccccaggct     1260

caggtgatct tcccacctca gccttccaag tagctgggac tacagatgca cacctccaaa     1320

cctgggtagt ttttgaagtt tttttgtaga ggtggtctag ccatgttgcc taggctcccg     1380

aactcctgag ctcaagcaat cctgcttcag cctcccaaag tactgggatt acaggcatct     1440

tctgtagtat ataggtcatg agggatatgg gatgtggtac ttatgagaca gaaatgctta     1500

caggatgttt ttctgtaacc atcctggtca acttagcaga aatgctgcgc tgggtataat     1560

aaagcttttc tacttctagt ctagacagga atcttacaga ttgtctcctg ttcaaaacct     1620

agtcataaat atttataatg caaactggtc aaaaaaaaaa aaaaaaaa                  1668


<210> 302
<211> 135
<212> PRT
<213> Homo sapiens

<400> 302
Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Arg His Gln Ser Asp Arg Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Ile Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Val Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Arg Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu Asn Glu 
    130                 135 


<210> 303
<211> 1767
<212> DNA
<213> Homo sapiens

<400> 303
aggggttacg acccatcagc ccttgcgcgc caccgtccct tctctcttcc tcggcgctgc       60

ctacggaggt ggcagccatc tccttctcgc tggcgattgg aagacactct gcgacagtgt      120

tcagtccctg ggcaggaaag cctccttcca ggattcttcc tcacctgggg ccgcttcttc      180

cccaaaaggc atcatggccg ccctcagacc ccttgtgaag cccaagatcg tcaaaaagag      240

aaccaagaag ttcatccggc accagtcaga ccgatatgtc aaaattaagc gtaactggcg      300

gaaacccaga ggcattgaca acagggttcg tagaagattc aagggccaga tcttgatgcc      360

caacattggt tatggaagca acaaaaaaac aaagcacatg ctgcccagtg gcttccggaa      420

gttcctggtc cacaacgtca aggagctgga agtgctgctg atgtgcaaca aatcttactg      480

tgccgagatc gctcacaatg tttcctccaa gaaccgcaaa gccatcgtgg aaagagctgc      540

ccaactggcc atcagagtca ccaaccccaa tgccaggctg cgcagtgaag aaaatgagta      600

ggcagctcat gtgcacgttt tctgtttaaa taaatgtaaa aactgccatc tggcatcttc      660

cttccttgat tttaagtctt cagcttcttg gccaacttag tttgccacag agattgttct      720

tttgcttaag cccctttgga atctcccatt tggaggggat ttgtaaagga cactcagtcc      780

ttgaacaggg gaatgtggcc tcaagtgcac agactagcct tagtcatctc cagttgaggc      840

tgggtatgag gggtacagac ttggccctca caccaggtag gttctgagac acttgaagaa      900

gcttgtggct cccaagccac aagtagtcat tcttagcctt gcttttgtaa agttaggtga      960

caagttattc catgtgatgc ttgtgagaat tgagaaaata tgcatggaaa tatccagatg     1020

aatttcttac acagattctt acgggatgcc taaattgcat cctgtaactt ctgtccaaaa     1080

agaacaggat gatgtacaaa ttgctcttcc aggtaatcca ccacggttaa ctggaaaagc     1140

actttcagtc tcctataacc ctcccaccag ctgctgcttc aggtataatg ttacagcagt     1200

ttgccaaggc ggggacctaa ctggtgacaa ttgagcctct tgactggtac tcagaattta     1260

gtgacacgtg gtcctgattt tttttggaga cggggtcttg ctctcaccca ggctgggagt     1320

gcagtggcac actgactaca gccttgacct ccccaggctc aggtgatctt cccacctcag     1380

ccttccaagt agctgggact acagatgcac acctccaaac ctgggtagtt tttgaagttt     1440

ttttgtagag gtggtctagc catgttgcct aggctcccga actcctgagc tcaagcaatc     1500

ctgcttcagc ctcccaaagt actgggatta caggcatctt ctgtagtata taggtcatga     1560

gggatatggg atgtggtact tatgagacag aaatgcttac aggatgtttt tctgtaacca     1620

tcctggtcaa cttagcagaa atgctgcgct gggtataata aagcttttct acttctagtc     1680

tagacaggaa tcttacagat tgtctcctgt tcaaaaccta gtcataaata tttataatgc     1740

aaactggtca aaaaaaaaaa aaaaaaa                                         1767


<210> 304
<211> 135
<212> PRT
<213> Homo sapiens

<400> 304
Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Arg His Gln Ser Asp Arg Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Ile Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Val Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Arg Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu Asn Glu 
    130                 135 


<210> 305
<211> 1787
<212> DNA
<213> Homo sapiens

<400> 305
gacctcctgg gatcgcatct ggagagtgcc tagtattctg ccagcttcgg aaagggaggg       60

aaagcaagcc tggcagaggc acccattcca ttcccagctt gctccgtagc tggcgattgg      120

aagacactct gcgacagtgt tcagtccctg ggcaggaaag cctccttcca ggattcttcc      180

tcacctgggg ccgcttcttc cccaaaaggc atcatggccg ccctcagacc ccttgtgaag      240

cccaagatcg tcaaaaagag aaccaagaag ttcatccggc accagtcaga ccgatatgtc      300

aaaattaagc gtaactggcg gaaacccaga ggcattgaca acagggttcg tagaagattc      360

aagggccaga tcttgatgcc caacattggt tatggaagca acaaaaaaac aaagcacatg      420

ctgcccagtg gcttccggaa gttcctggtc cacaacgtca aggagctgga agtgctgctg      480

atgtgcaaca aatcttactg tgccgagatc gctcacaatg tttcctccaa gaaccgcaaa      540

gccatcgtgg aaagagctgc ccaactggcc atcagagtca ccaaccccaa tgccaggctg      600

cgcagtgaag aaaatgagta ggcagctcat gtgcacgttt tctgtttaaa taaatgtaaa      660

aactgccatc tggcatcttc cttccttgat tttaagtctt cagcttcttg gccaacttag      720

tttgccacag agattgttct tttgcttaag cccctttgga atctcccatt tggaggggat      780

ttgtaaagga cactcagtcc ttgaacaggg gaatgtggcc tcaagtgcac agactagcct      840

tagtcatctc cagttgaggc tgggtatgag gggtacagac ttggccctca caccaggtag      900

gttctgagac acttgaagaa gcttgtggct cccaagccac aagtagtcat tcttagcctt      960

gcttttgtaa agttaggtga caagttattc catgtgatgc ttgtgagaat tgagaaaata     1020

tgcatggaaa tatccagatg aatttcttac acagattctt acgggatgcc taaattgcat     1080

cctgtaactt ctgtccaaaa agaacaggat gatgtacaaa ttgctcttcc aggtaatcca     1140

ccacggttaa ctggaaaagc actttcagtc tcctataacc ctcccaccag ctgctgcttc     1200

aggtataatg ttacagcagt ttgccaaggc ggggacctaa ctggtgacaa ttgagcctct     1260

tgactggtac tcagaattta gtgacacgtg gtcctgattt tttttggaga cggggtcttg     1320

ctctcaccca ggctgggagt gcagtggcac actgactaca gccttgacct ccccaggctc     1380

aggtgatctt cccacctcag ccttccaagt agctgggact acagatgcac acctccaaac     1440

ctgggtagtt tttgaagttt ttttgtagag gtggtctagc catgttgcct aggctcccga     1500

actcctgagc tcaagcaatc ctgcttcagc ctcccaaagt actgggatta caggcatctt     1560

ctgtagtata taggtcatga gggatatggg atgtggtact tatgagacag aaatgcttac     1620

aggatgtttt tctgtaacca tcctggtcaa cttagcagaa atgctgcgct gggtataata     1680

aagcttttct acttctagtc tagacaggaa tcttacagat tgtctcctgt tcaaaaccta     1740

gtcataaata tttataatgc aaactggtca aaaaaaaaaa aaaaaaa                   1787


<210> 306
<211> 135
<212> PRT
<213> Homo sapiens

<400> 306
Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Arg His Gln Ser Asp Arg Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Ile Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Val Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Arg Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu Asn Glu 
    130                 135 


<210> 307
<211> 556
<212> DNA
<213> Homo sapiens

<400> 307
tgacccactt ccgttacttg ctgcggagga ccgtgggcag ccagggtcgg tgaaggatcc       60

caaaatggct gggcgaaaac ttgctctaaa aaccattgac tgggtagctt ttgcagagat      120

cataccccag aaccaaaagg ccattgctag ttccctgaaa tcctggaatg agaccctcac      180

ctccaggttg gctgctttac ctgagaatcc accagctatc gactgggctt actacaaggc      240

caatgtggcc aaggctggct tggtggatga ctttgagaag aaggtgaaat cttgtgctga      300

gtgggtgtct ctctcaaagg ccaggattgt agaatatgag aaagagatgg agaagatgaa      360

gaacttaatt ccatttgatc agatgaccat tgaggacttg aatgaagctt tcccagaaac      420

caaattagac aagaaaaagt atccctattg gcctcaccaa ccaattgaga atttataaaa      480

ttgagtccag gaggaagctc tggcccttgt attacacatt ctggacatta aaaataataa      540

ttatacagtt aaaaaa                                                      556


<210> 308
<211> 137
<212> PRT
<213> Homo sapiens

<400> 308
Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ala Phe 
1               5                   10                  15      


Ala Glu Ile Ile Pro Gln Asn Gln Lys Ala Ile Ala Ser Ser Leu Lys 
            20                  25                  30          


Ser Trp Asn Glu Thr Leu Thr Ser Arg Leu Ala Ala Leu Pro Glu Asn 
        35                  40                  45              


Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Lys Ala Asn Val Ala Lys Ala 
    50                  55                  60                  


Gly Leu Val Asp Asp Phe Glu Lys Lys Val Lys Ser Cys Ala Glu Trp 
65                  70                  75                  80  


Val Ser Leu Ser Lys Ala Arg Ile Val Glu Tyr Glu Lys Glu Met Glu 
                85                  90                  95      


Lys Met Lys Asn Leu Ile Pro Phe Asp Gln Met Thr Ile Glu Asp Leu 
            100                 105                 110         


Asn Glu Ala Phe Pro Glu Thr Lys Leu Asp Lys Lys Lys Tyr Pro Tyr 
        115                 120                 125             


Trp Pro His Gln Pro Ile Glu Asn Leu 
    130                 135         


<210> 309
<211> 628
<212> DNA
<213> Homo sapiens

<400> 309
tgacccactt ccgttacttg ctgcggagga ccgtgggcag ccagggtcgg tgaaggatcc       60

caaaatggct gggcgaaaac ttgctctaaa aaccattgac tgggtagctt ttgcagagat      120

cataccccag aaccaaaagg ccattgctag ttccctgaaa tcctggaatg agaccctcac      180

ctccaggttg gctgctttac ctgagaatcc accagctatc gactgggctt actacaaggc      240

caatgtggcc aaggctggct tggtggatga ctttgagaag aagtttaatg cgctgaaggt      300

tcccgtgcca gaggataaat atactgccca ggtggatgcc gaagaaaaag aagatgtgaa      360

atcttgtgct gagtgggtgt ctctctcaaa ggccaggatt gtagaatatg agaaagagat      420

ggagaagatg aagaacttaa ttccatttga tcagatgacc attgaggact tgaatgaagc      480

tttcccagaa accaaattag acaagaaaaa gtatccctat tggcctcacc aaccaattga      540

gaatttataa aattgagtcc aggaggaagc tctggccctt gtattacaca ttctggacat      600

taaaaataat aattatacag ttaaaaaa                                         628


<210> 310
<211> 161
<212> PRT
<213> Homo sapiens

<400> 310
Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ala Phe 
1               5                   10                  15      


Ala Glu Ile Ile Pro Gln Asn Gln Lys Ala Ile Ala Ser Ser Leu Lys 
            20                  25                  30          


Ser Trp Asn Glu Thr Leu Thr Ser Arg Leu Ala Ala Leu Pro Glu Asn 
        35                  40                  45              


Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Lys Ala Asn Val Ala Lys Ala 
    50                  55                  60                  


Gly Leu Val Asp Asp Phe Glu Lys Lys Phe Asn Ala Leu Lys Val Pro 
65                  70                  75                  80  


Val Pro Glu Asp Lys Tyr Thr Ala Gln Val Asp Ala Glu Glu Lys Glu 
                85                  90                  95      


Asp Val Lys Ser Cys Ala Glu Trp Val Ser Leu Ser Lys Ala Arg Ile 
            100                 105                 110         


Val Glu Tyr Glu Lys Glu Met Glu Lys Met Lys Asn Leu Ile Pro Phe 
        115                 120                 125             


Asp Gln Met Thr Ile Glu Asp Leu Asn Glu Ala Phe Pro Glu Thr Lys 
    130                 135                 140                 


Leu Asp Lys Lys Lys Tyr Pro Tyr Trp Pro His Gln Pro Ile Glu Asn 
145                 150                 155                 160 


Leu 
    


<210> 311
<211> 926
<212> DNA
<213> Homo sapiens

<400> 311
gatatctctg gaatagactg cgctaccctg cgccgccgcc gtcaaactcc cgcagacttc       60

tctgtagatc gctgagcgat actttcggca gcacctcctt gattctcagt tttgctggag      120

gccgcaacca ggcccgcgcc gccaccatgt ttcgaaatca gtatgacaat gatgtcactg      180

tttggagccc ccagggcagg attcatcaaa ttgaatatgc aatggaagct gttaaacaag      240

gttcagccac agttggtctg aaatcaaaaa ctcatgcagt tttggttgca ttgaaaaggg      300

cgcaatcaga gcttgcagct catcagaaaa aaattctcca tgttgacaac catattggta      360

tctcaattgc ggggcttact gctgatgcta gactgttatg taattttatg cgtcaggagt      420

gtttggattc cagatttgta ttcgatagac cactgcctgt gtctcgtctt gtatctctaa      480

ttggaagcag tatccttttt atgttagcat ttatggatat gaactttgaa gggttttgat      540

acttgtgtta attattagga atataataat aatatgacat aggtaagatt gtgaaaactt      600

taaaacaaca aattggattg ctctttcatt agcctttata agcaatttat atttgctaga      660

cacaaataag cccaacttca ggaaaatcat ctaagcatct ttttagaggg gatttaaagt      720

ttcttaatgg ttctagatgt cccaagaaat cctagacccc ttgtatccaa aacaaatcag      780

gttttagatg ggaagaaatt attttgctgg cactctttct taggttcggt agaaagtcaa      840

acattttata ttaggccaaa gaaatagtgt cctattgcat tatttctctg gtggattatg      900

caacaattaa agaataagcc agagac                                           926


<210> 312
<211> 130
<212> PRT
<213> Homo sapiens

<400> 312
Met Phe Arg Asn Gln Tyr Asp Asn Asp Val Thr Val Trp Ser Pro Gln 
1               5                   10                  15      


Gly Arg Ile His Gln Ile Glu Tyr Ala Met Glu Ala Val Lys Gln Gly 
            20                  25                  30          


Ser Ala Thr Val Gly Leu Lys Ser Lys Thr His Ala Val Leu Val Ala 
        35                  40                  45              


Leu Lys Arg Ala Gln Ser Glu Leu Ala Ala His Gln Lys Lys Ile Leu 
    50                  55                  60                  


His Val Asp Asn His Ile Gly Ile Ser Ile Ala Gly Leu Thr Ala Asp 
65                  70                  75                  80  


Ala Arg Leu Leu Cys Asn Phe Met Arg Gln Glu Cys Leu Asp Ser Arg 
                85                  90                  95      


Phe Val Phe Asp Arg Pro Leu Pro Val Ser Arg Leu Val Ser Leu Ile 
            100                 105                 110         


Gly Ser Ser Ile Leu Phe Met Leu Ala Phe Met Asp Met Asn Phe Glu 
        115                 120                 125             


Gly Phe 
    130 


<210> 313
<211> 1281
<212> DNA
<213> Homo sapiens

<400> 313
gatatctctg gaatagactg cgctaccctg cgccgccgcc gtcaaactcc cgcagacttc       60

tctgtagatc gctgagcgat actttcggca gcacctcctt gattctcagt tttgctggag      120

gccgcaacca ggcccgcgcc gccaccatgt ttcgaaatca gtatgacaat gatgtcactg      180

tttggagccc ccagggcagg attcatcaaa ttgaatatgc aatggaagct gttaaacaag      240

gttcagccac agttggtctg aaatcaaaaa ctcatgcagt tttggttgca ttgaaaaggg      300

cgcaatcaga gcttgcagct catcagaaaa aaattctcca tgttgacaac catattggta      360

tctcaattgc ggggcttact gctgatgcta gactgttatg taattttatg cgtcaggagt      420

gtttggattc cagatttgta ttcgatagac cactgcctgt gtctcgtctt gtatctctaa      480

ttggaagcaa gacccagata ccaacacaac gatatggccg gagaccatat ggtgttggtc      540

tccttattgc tggttatgat gatatgggcc ctcacatttt ccaaacctgt ccatctgcta      600

actattttga ctgcagagcc atgtccattg gagcccgttc ccaatcagct cgtacttact      660

tggagagaca tatgtctgaa tttatggagt gtaatttaaa tgaactagtt aaacatggtc      720

tgcgtgcctt aagagagacg cttcctgcag aacaggacct gactacaaag aatgtttcca      780

ttggaattgt tggtaaagac ttggagttta caatctatga tgatgatgat gtgtctccat      840

tcctggaagg tcttgaagaa agaccacaga gaaaggcaca gcctgctcaa cctgctgatg      900

aacctgcaga aaaggctgat gaaccaatgg aacattaagt gataagccag tctatatatg      960

tattatcaaa tatgtaagaa tacaggcacc acatactgat gacaataatc tatactttga     1020

accaaaagtt gcagagtggt ggaatgctat gttttaggaa tcagtccaga tgtgagtttt     1080

ttccaagcaa cctcactgaa acctatataa tggaatacat ttttctttga aagggtctgt     1140

ataatcattt tctagaaagt atgggtatct atactaatgt ttttatatga agaacatagg     1200

tgtctttgtg gttttaaaga caactgtgaa ataaaattgt ttcaccgcct ggtaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa a                                               1281


<210> 314
<211> 263
<212> PRT
<213> Homo sapiens

<400> 314
Met Phe Arg Asn Gln Tyr Asp Asn Asp Val Thr Val Trp Ser Pro Gln 
1               5                   10                  15      


Gly Arg Ile His Gln Ile Glu Tyr Ala Met Glu Ala Val Lys Gln Gly 
            20                  25                  30          


Ser Ala Thr Val Gly Leu Lys Ser Lys Thr His Ala Val Leu Val Ala 
        35                  40                  45              


Leu Lys Arg Ala Gln Ser Glu Leu Ala Ala His Gln Lys Lys Ile Leu 
    50                  55                  60                  


His Val Asp Asn His Ile Gly Ile Ser Ile Ala Gly Leu Thr Ala Asp 
65                  70                  75                  80  


Ala Arg Leu Leu Cys Asn Phe Met Arg Gln Glu Cys Leu Asp Ser Arg 
                85                  90                  95      


Phe Val Phe Asp Arg Pro Leu Pro Val Ser Arg Leu Val Ser Leu Ile 
            100                 105                 110         


Gly Ser Lys Thr Gln Ile Pro Thr Gln Arg Tyr Gly Arg Arg Pro Tyr 
        115                 120                 125             


Gly Val Gly Leu Leu Ile Ala Gly Tyr Asp Asp Met Gly Pro His Ile 
    130                 135                 140                 


Phe Gln Thr Cys Pro Ser Ala Asn Tyr Phe Asp Cys Arg Ala Met Ser 
145                 150                 155                 160 


Ile Gly Ala Arg Ser Gln Ser Ala Arg Thr Tyr Leu Glu Arg His Met 
                165                 170                 175     


Ser Glu Phe Met Glu Cys Asn Leu Asn Glu Leu Val Lys His Gly Leu 
            180                 185                 190         


Arg Ala Leu Arg Glu Thr Leu Pro Ala Glu Gln Asp Leu Thr Thr Lys 
        195                 200                 205             


Asn Val Ser Ile Gly Ile Val Gly Lys Asp Leu Glu Phe Thr Ile Tyr 
    210                 215                 220                 


Asp Asp Asp Asp Val Ser Pro Phe Leu Glu Gly Leu Glu Glu Arg Pro 
225                 230                 235                 240 


Gln Arg Lys Ala Gln Pro Ala Gln Pro Ala Asp Glu Pro Ala Glu Lys 
                245                 250                 255     


Ala Asp Glu Pro Met Glu His 
            260             


<210> 315
<211> 1498
<212> DNA
<213> Homo sapiens

<400> 315
cggccgccca acagggacgc gagccgggac cacgccgacc cagcgtgccc aggccgagga       60

aagcgcggcg gcggcagtcc gaagacccac cgggactgaa agagaaggac gaggtcatct      120

tcggacggga ggggcaagcc agccatcctg ggaccccagg cgtgcaggtt ctctttgagg      180

gtattccacc ctgcaaaaag catgtattca tggtcagctc tcagcaaggc cagtagcaga      240

gtggtaaagg ccttggccct ccaaggctgg gaaaagacaa tgacaagtca aatccagacc      300

tatgttgtat gttggtctac taggtgactg tctcctggaa atgttatgca gctcagcaag      360

gtgaagtttc gaaatcagta tgacaatgat gtcactgttt ggagccccca gggcaggatt      420

catcaaattg aatatgcaat ggaagctgtt aaacaaggtt cagccacagt tggtctgaaa      480

tcaaaaactc atgcagtttt ggttgcattg aaaagggcgc aatcagagct tgcagctcat      540

cagaaaaaaa ttctccatgt tgacaaccat attggtatct caattgcggg gcttactgct      600

gatgctagac tgttatgtaa ttttatgcgt caggagtgtt tggattccag atttgtattc      660

gatagaccac tgcctgtgtc tcgtcttgta tctctaattg gaagcaagac ccagatacca      720

acacaacgat atggccggag accatatggt gttggtctcc ttattgctgg ttatgatgat      780

atgggccctc acattttcca aacctgtcca tctgctaact attttgactg cagagccatg      840

tccattggag cccgttccca atcagctcgt acttacttgg agagacatat gtctgaattt      900

atggagtgta atttaaatga actagttaaa catggtctgc gtgccttaag agagacgctt      960

cctgcagaac aggacctgac tacaaagaat gtttccattg gaattgttgg taaagacttg     1020

gagtttacaa tctatgatga tgatgatgtg tctccattcc tggaaggtct tgaagaaaga     1080

ccacagagaa aggcacagcc tgctcaacct gctgatgaac ctgcagaaaa ggctgatgaa     1140

ccaatggaac attaagtgat aagccagtct atatatgtat tatcaaatat gtaagaatac     1200

aggcaccaca tactgatgac aataatctat actttgaacc aaaagttgca gagtggtgga     1260

atgctatgtt ttaggaatca gtccagatgt gagttttttc caagcaacct cactgaaacc     1320

tatataatgg aatacatttt tctttgaaag ggtctgtata atcattttct agaaagtatg     1380

ggtatctata ctaatgtttt tatatgaaga acataggtgt ctttgtggtt ttaaagacaa     1440

ctgtgaaata aaattgtttc accgcctggt aaaaaaaaaa aaaaaaaaaa aaaaaaaa       1498


<210> 316
<211> 269
<212> PRT
<213> Homo sapiens

<400> 316
Met Gln Leu Ser Lys Val Lys Phe Arg Asn Gln Tyr Asp Asn Asp Val 
1               5                   10                  15      


Thr Val Trp Ser Pro Gln Gly Arg Ile His Gln Ile Glu Tyr Ala Met 
            20                  25                  30          


Glu Ala Val Lys Gln Gly Ser Ala Thr Val Gly Leu Lys Ser Lys Thr 
        35                  40                  45              


His Ala Val Leu Val Ala Leu Lys Arg Ala Gln Ser Glu Leu Ala Ala 
    50                  55                  60                  


His Gln Lys Lys Ile Leu His Val Asp Asn His Ile Gly Ile Ser Ile 
65                  70                  75                  80  


Ala Gly Leu Thr Ala Asp Ala Arg Leu Leu Cys Asn Phe Met Arg Gln 
                85                  90                  95      


Glu Cys Leu Asp Ser Arg Phe Val Phe Asp Arg Pro Leu Pro Val Ser 
            100                 105                 110         


Arg Leu Val Ser Leu Ile Gly Ser Lys Thr Gln Ile Pro Thr Gln Arg 
        115                 120                 125             


Tyr Gly Arg Arg Pro Tyr Gly Val Gly Leu Leu Ile Ala Gly Tyr Asp 
    130                 135                 140                 


Asp Met Gly Pro His Ile Phe Gln Thr Cys Pro Ser Ala Asn Tyr Phe 
145                 150                 155                 160 


Asp Cys Arg Ala Met Ser Ile Gly Ala Arg Ser Gln Ser Ala Arg Thr 
                165                 170                 175     


Tyr Leu Glu Arg His Met Ser Glu Phe Met Glu Cys Asn Leu Asn Glu 
            180                 185                 190         


Leu Val Lys His Gly Leu Arg Ala Leu Arg Glu Thr Leu Pro Ala Glu 
        195                 200                 205             


Gln Asp Leu Thr Thr Lys Asn Val Ser Ile Gly Ile Val Gly Lys Asp 
    210                 215                 220                 


Leu Glu Phe Thr Ile Tyr Asp Asp Asp Asp Val Ser Pro Phe Leu Glu 
225                 230                 235                 240 


Gly Leu Glu Glu Arg Pro Gln Arg Lys Ala Gln Pro Ala Gln Pro Ala 
                245                 250                 255     


Asp Glu Pro Ala Glu Lys Ala Asp Glu Pro Met Glu His 
            260                 265                 


<210> 317
<211> 3340
<212> DNA
<213> Homo sapiens

<400> 317
tgcgggcgtc tccgccattt tgtgagtcta taactcggag ccgttgggtc ggttcctgct       60

attccggcgc ctccactccg tcccccgcgg gtctgctctg tgtgccatgg acggcattgt      120

cccagatata gccgttggta caaagcgggg atctgacgag cttttctcta cttgtgtcac      180

taacggaccg tttatcatga gcagcaactc ggcttctgca gcaaacggaa atgacagcaa      240

gaagttcaaa ggtgacagcc gaagtgcagg cgtcccctct agagtgatcc acatccggaa      300

gctccccatc gacgtcacgg agggggaagt catctccctg gggctgccct ttgggaaggt      360

caccaacctc ctgatgctga aggggaaaaa ccaggccttc atcgagatga acacggagga      420

ggctgccaac accatggtga actactacac ctcggtgacc cctgtgctgc gcggccagcc      480

catctacatc cagttctcca accacaagga gctgaagacc gacagctctc ccaaccaggc      540

gcgggcccag gcggccctgc aggcggtgaa ctcggtccag tcggggaacc tggccttggc      600

tgcctcggcg gcggccgtgg acgcagggat ggcgatggcc gggcagagcc ccgtgctcag      660

gatcatcgtg gagaacctct tctaccctgt gaccctggat gtgctgcacc agattttctc      720

caagttcggc acagtgttga agatcatcac cttcaccaag aacaaccagt tccaggccct      780

gctgcagtat gcggaccccg tgagcgccca gcacgccaag ctgtcgctgg acgggcagaa      840

catctacaac gcctgctgca cgctgcgcat cgacttttcc aagctcacca gcctcaacgt      900

caagtacaac aatgacaaga gccgtgacta cacacgccca gacctgcctt ccggggacag      960

ccagccctcg ctggaccaga ccatggccgc ggccttcggt gcacctggta taatctcagc     1020

ctctccgtat gcaggagctg gtttccctcc cacctttgcc attcctcaag ctgcaggcct     1080

ttccgttccg aacgtccacg gcgccctggc ccccctggcc atcccctcgg cggcggcggc     1140

agctgcggcg gcaggtcgga tcgccatccc gggcctggcg ggggcaggaa attctgtatt     1200

gctggtcagc aacctcaacc cagagagagt cacaccccaa agcctcttta ttcttttcgg     1260

cgtctacggt gacgtgcagc gcgtgaagat cctgttcaat aagaaggaga acgccctagt     1320

gcagatggcg gacggcaacc aggcccagct ggccatgagc cacctgaacg ggcacaagct     1380

gcacgggaag cccatccgca tcacgctctc gaagcaccag aacgtgcagc tgccccgcga     1440

gggccaggag gaccagggcc tgaccaagga ctacggcaac tcacccctgc accgcttcaa     1500

gaagccgggc tccaagaact tccagaacat attcccgccc tcggccacgc tgcacctctc     1560

caacatcccg ccctcagtct ccgaggagga tctcaaggtc ctgttttcca gcaatggggg     1620

cgtcgtcaaa ggattcaagt tcttccagaa ggaccgcaag atggcactga tccagatggg     1680

ctccgtggag gaggcggtcc aggccctcat tgacctgcac aaccacgacc tcggggagaa     1740

ccaccacctg cgggtctcct tctccaagtc caccatctag gggcacaggc ccccacggcc     1800

gggccccctg gcgacaactt ccatcattcc agagaaaagc cactttaaaa acagctgaag     1860

tgaccttagc agaccagaga ttttattttt ttaaagagaa atcagtttac ctgtttttaa     1920

aaaaattaaa tctagttcac cttgctcacc ctgcggtgac agggacagct caggctcttg     1980

gtgactgtgg cagcgggagt tcccggccct ccacacccgg ggccagaccc tcggggccat     2040

gccttggtgg ggcctgtgtc gggcgtgggg cctgcaggtg ggcgccccga ccacgacttg     2100

gcttccttgt gccttaaaaa acctgccttc ctgcagccac acacccaccc ggggtgtcct     2160

ggggacccaa ggggtggggg ggtcacacca gagagaggca gggggcctgg ccggctcctg     2220

caggatcatg cagctggggc gcggcggccg cggctgcgac accccaaccc cagccctcta     2280

atcaagtcac gtgattctcc cttcaccccg cccccagggc cttcccttct gcccccaggc     2340

gggctccccg ctgctccagc tgcggagctg gtcgacataa tctctgtatt atatactttg     2400

cagttgcaga cgtctgtgcc tagcaatatt tccagttgac caaatattct aatctttttt     2460

catttatatg caaaagaaat agttttaagt aactttttat agcaagatga tacaatggta     2520

tgagtgtaat ctaaacttcc ttgtggtatt accttgtatg ctgttacttt tattttattc     2580

cttgtaatta agtcacaggc aggacccagt ttccagagag caggcggggc cgcccagtgg     2640

gtcaggcaca gggagccccg gtcctatctt agagcccctg agcttcaggg aaggggcggg     2700

cgtgtcgccg cctctggcat cgcctccggt tgccttacac cacgccttca cctgcagtcg     2760

cctagaaaac ttgctctcaa acttcagggt tttttcttcc ttcaaatttt ggaccaaagt     2820

ctcatttctg tgttttgcct gcctctgatg ctgggacccg gaaggcgggc gctcctcctg     2880

tcttctctgt gctctttcta ccgcccccgc gtcctgtccc gggggctctc ctaggatccc     2940

ctttccgtaa aagcgtgtaa caagggtgta aatatttata attttttata cctgttgtga     3000

gacccgaggg gcggcggcgc ggttttttat ggtgacacaa atgtatattt tgctaacagc     3060

aattccaggc tcagtattgt gaccgcggag ccacagggga ccccacgcac attccgttgc     3120

cttacccgat ggcttgtgac gcggagagaa ccgattaaaa ccgtttgaga aactcctccc     3180

ttgtctagcc ctgtgttcgc tgtggacgct gtagaggcag gttggccagt ctgtacctgg     3240

acttcgaata aatcttctgt atcctcgctc cgttccgcct taaaaaaaaa aaaaaaaaaa     3300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           3340


<210> 318
<211> 557
<212> PRT
<213> Homo sapiens

<400> 318
Met Asp Gly Ile Val Pro Asp Ile Ala Val Gly Thr Lys Arg Gly Ser 
1               5                   10                  15      


Asp Glu Leu Phe Ser Thr Cys Val Thr Asn Gly Pro Phe Ile Met Ser 
            20                  25                  30          


Ser Asn Ser Ala Ser Ala Ala Asn Gly Asn Asp Ser Lys Lys Phe Lys 
        35                  40                  45              


Gly Asp Ser Arg Ser Ala Gly Val Pro Ser Arg Val Ile His Ile Arg 
    50                  55                  60                  


Lys Leu Pro Ile Asp Val Thr Glu Gly Glu Val Ile Ser Leu Gly Leu 
65                  70                  75                  80  


Pro Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Asn Gln 
                85                  90                  95      


Ala Phe Ile Glu Met Asn Thr Glu Glu Ala Ala Asn Thr Met Val Asn 
            100                 105                 110         


Tyr Tyr Thr Ser Val Thr Pro Val Leu Arg Gly Gln Pro Ile Tyr Ile 
        115                 120                 125             


Gln Phe Ser Asn His Lys Glu Leu Lys Thr Asp Ser Ser Pro Asn Gln 
    130                 135                 140                 


Ala Arg Ala Gln Ala Ala Leu Gln Ala Val Asn Ser Val Gln Ser Gly 
145                 150                 155                 160 


Asn Leu Ala Leu Ala Ala Ser Ala Ala Ala Val Asp Ala Gly Met Ala 
                165                 170                 175     


Met Ala Gly Gln Ser Pro Val Leu Arg Ile Ile Val Glu Asn Leu Phe 
            180                 185                 190         


Tyr Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys Phe Gly 
        195                 200                 205             


Thr Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe Gln Ala 
    210                 215                 220                 


Leu Leu Gln Tyr Ala Asp Pro Val Ser Ala Gln His Ala Lys Leu Ser 
225                 230                 235                 240 


Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg Ile Asp 
                245                 250                 255     


Phe Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser 
            260                 265                 270         


Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Ser Gln Pro Ser 
        275                 280                 285             


Leu Asp Gln Thr Met Ala Ala Ala Phe Gly Ala Pro Gly Ile Ile Ser 
    290                 295                 300                 


Ala Ser Pro Tyr Ala Gly Ala Gly Phe Pro Pro Thr Phe Ala Ile Pro 
305                 310                 315                 320 


Gln Ala Ala Gly Leu Ser Val Pro Asn Val His Gly Ala Leu Ala Pro 
                325                 330                 335     


Leu Ala Ile Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Ile 
            340                 345                 350         


Ala Ile Pro Gly Leu Ala Gly Ala Gly Asn Ser Val Leu Leu Val Ser 
        355                 360                 365             


Asn Leu Asn Pro Glu Arg Val Thr Pro Gln Ser Leu Phe Ile Leu Phe 
    370                 375                 380                 


Gly Val Tyr Gly Asp Val Gln Arg Val Lys Ile Leu Phe Asn Lys Lys 
385                 390                 395                 400 


Glu Asn Ala Leu Val Gln Met Ala Asp Gly Asn Gln Ala Gln Leu Ala 
                405                 410                 415     


Met Ser His Leu Asn Gly His Lys Leu His Gly Lys Pro Ile Arg Ile 
            420                 425                 430         


Thr Leu Ser Lys His Gln Asn Val Gln Leu Pro Arg Glu Gly Gln Glu 
        435                 440                 445             


Asp Gln Gly Leu Thr Lys Asp Tyr Gly Asn Ser Pro Leu His Arg Phe 
    450                 455                 460                 


Lys Lys Pro Gly Ser Lys Asn Phe Gln Asn Ile Phe Pro Pro Ser Ala 
465                 470                 475                 480 


Thr Leu His Leu Ser Asn Ile Pro Pro Ser Val Ser Glu Glu Asp Leu 
                485                 490                 495     


Lys Val Leu Phe Ser Ser Asn Gly Gly Val Val Lys Gly Phe Lys Phe 
            500                 505                 510         


Phe Gln Lys Asp Arg Lys Met Ala Leu Ile Gln Met Gly Ser Val Glu 
        515                 520                 525             


Glu Ala Val Gln Ala Leu Ile Asp Leu His Asn His Asp Leu Gly Glu 
    530                 535                 540                 


Asn His His Leu Arg Val Ser Phe Ser Lys Ser Thr Ile 
545                 550                 555         


<210> 319
<211> 3319
<212> DNA
<213> Homo sapiens

<400> 319
tgcgggcgtc tccgccattt tgtgagtcta taactcggag ccgttgggtc ggttcctgct       60

attccggcgc ctccactccg tcccccgcgg gtctgctctg tgtgccatgg acggcattgt      120

cccagatata gccgttggta caaagcgggg atctgacgag cttttctcta cttgtgtcac      180

taacggaccg tttatcatga gcagcaactc ggcttctgca gcaaacggaa atgacagcaa      240

gaagttcaaa ggtgacagcc gaagtgcagg cgtcccctct agagtgatcc acatccggaa      300

gctccccatc gacgtcacgg agggggaagt catctccctg gggctgccct ttgggaaggt      360

caccaacctc ctgatgctga aggggaaaaa ccaggccttc atcgagatga acacggagga      420

ggctgccaac accatggtga actactacac ctcggtgacc cctgtgctgc gcggccagcc      480

catctacatc cagttctcca accacaagga gctgaagacc gacagctctc ccaaccaggc      540

gcgggcccag gcggccctgc aggcggtgaa ctcggtccag tcggggaacc tggccttggc      600

tgcctcggcg gcggccgtgg acgcagggat ggcgatggcc gggcagagcc ccgtgctcag      660

gatcatcgtg gagaacctct tctaccctgt gaccctggat gtgctgcacc agattttctc      720

caagttcggc acagtgttga agatcatcac cttcaccaag aacaaccagt tccaggccct      780

gctgcagtat gcggaccccg tgagcgccca gcacgccaag ctgtcgctgg acgggcagaa      840

catctacaac gcctgctgca cgctgcgcat cgacttttcc aagctcacca gcctcaacgt      900

caagtacaac aatgacaaga gccgtgacta cacacgccca gacctgcctt ccggggacag      960

ccagccctcg ctggaccaga ccatggccgc ggccttcgcc tctccgtatg caggagctgg     1020

tttccctccc acctttgcca ttcctcaagc tgcaggcctt tccgttccga acgtccacgg     1080

cgccctggcc cccctggcca tcccctcggc ggcggcggca gctgcggcgg caggtcggat     1140

cgccatcccg ggcctggcgg gggcaggaaa ttctgtattg ctggtcagca acctcaaccc     1200

agagagagtc acaccccaaa gcctctttat tcttttcggc gtctacggtg acgtgcagcg     1260

cgtgaagatc ctgttcaata agaaggagaa cgccctagtg cagatggcgg acggcaacca     1320

ggcccagctg gccatgagcc acctgaacgg gcacaagctg cacgggaagc ccatccgcat     1380

cacgctctcg aagcaccaga acgtgcagct gccccgcgag ggccaggagg accagggcct     1440

gaccaaggac tacggcaact cacccctgca ccgcttcaag aagccgggct ccaagaactt     1500

ccagaacata ttcccgccct cggccacgct gcacctctcc aacatcccgc cctcagtctc     1560

cgaggaggat ctcaaggtcc tgttttccag caatgggggc gtcgtcaaag gattcaagtt     1620

cttccagaag gaccgcaaga tggcactgat ccagatgggc tccgtggagg aggcggtcca     1680

ggccctcatt gacctgcaca accacgacct cggggagaac caccacctgc gggtctcctt     1740

ctccaagtcc accatctagg ggcacaggcc cccacggccg ggccccctgg cgacaacttc     1800

catcattcca gagaaaagcc actttaaaaa cagctgaagt gaccttagca gaccagagat     1860

tttatttttt taaagagaaa tcagtttacc tgtttttaaa aaaattaaat ctagttcacc     1920

ttgctcaccc tgcggtgaca gggacagctc aggctcttgg tgactgtggc agcgggagtt     1980

cccggccctc cacacccggg gccagaccct cggggccatg ccttggtggg gcctgtgtcg     2040

ggcgtggggc ctgcaggtgg gcgccccgac cacgacttgg cttccttgtg ccttaaaaaa     2100

cctgccttcc tgcagccaca cacccacccg gggtgtcctg gggacccaag gggtgggggg     2160

gtcacaccag agagaggcag ggggcctggc cggctcctgc aggatcatgc agctggggcg     2220

cggcggccgc ggctgcgaca ccccaacccc agccctctaa tcaagtcacg tgattctccc     2280

ttcaccccgc ccccagggcc ttcccttctg cccccaggcg ggctccccgc tgctccagct     2340

gcggagctgg tcgacataat ctctgtatta tatactttgc agttgcagac gtctgtgcct     2400

agcaatattt ccagttgacc aaatattcta atcttttttc atttatatgc aaaagaaata     2460

gttttaagta actttttata gcaagatgat acaatggtat gagtgtaatc taaacttcct     2520

tgtggtatta ccttgtatgc tgttactttt attttattcc ttgtaattaa gtcacaggca     2580

ggacccagtt tccagagagc aggcggggcc gcccagtggg tcaggcacag ggagccccgg     2640

tcctatctta gagcccctga gcttcaggga aggggcgggc gtgtcgccgc ctctggcatc     2700

gcctccggtt gccttacacc acgccttcac ctgcagtcgc ctagaaaact tgctctcaaa     2760

cttcagggtt ttttcttcct tcaaattttg gaccaaagtc tcatttctgt gttttgcctg     2820

cctctgatgc tgggacccgg aaggcgggcg ctcctcctgt cttctctgtg ctctttctac     2880

cgcccccgcg tcctgtcccg ggggctctcc taggatcccc tttccgtaaa agcgtgtaac     2940

aagggtgtaa atatttataa ttttttatac ctgttgtgag acccgagggg cggcggcgcg     3000

gttttttatg gtgacacaaa tgtatatttt gctaacagca attccaggct cagtattgtg     3060

accgcggagc cacaggggac cccacgcaca ttccgttgcc ttacccgatg gcttgtgacg     3120

cggagagaac cgattaaaac cgtttgagaa actcctccct tgtctagccc tgtgttcgct     3180

gtggacgctg tagaggcagg ttggccagtc tgtacctgga cttcgaataa atcttctgta     3240

tcctcgctcc gttccgcctt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3300

aaaaaaaaaa aaaaaaaaa                                                  3319


<210> 320
<211> 550
<212> PRT
<213> Homo sapiens

<400> 320
Met Asp Gly Ile Val Pro Asp Ile Ala Val Gly Thr Lys Arg Gly Ser 
1               5                   10                  15      


Asp Glu Leu Phe Ser Thr Cys Val Thr Asn Gly Pro Phe Ile Met Ser 
            20                  25                  30          


Ser Asn Ser Ala Ser Ala Ala Asn Gly Asn Asp Ser Lys Lys Phe Lys 
        35                  40                  45              


Gly Asp Ser Arg Ser Ala Gly Val Pro Ser Arg Val Ile His Ile Arg 
    50                  55                  60                  


Lys Leu Pro Ile Asp Val Thr Glu Gly Glu Val Ile Ser Leu Gly Leu 
65                  70                  75                  80  


Pro Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Asn Gln 
                85                  90                  95      


Ala Phe Ile Glu Met Asn Thr Glu Glu Ala Ala Asn Thr Met Val Asn 
            100                 105                 110         


Tyr Tyr Thr Ser Val Thr Pro Val Leu Arg Gly Gln Pro Ile Tyr Ile 
        115                 120                 125             


Gln Phe Ser Asn His Lys Glu Leu Lys Thr Asp Ser Ser Pro Asn Gln 
    130                 135                 140                 


Ala Arg Ala Gln Ala Ala Leu Gln Ala Val Asn Ser Val Gln Ser Gly 
145                 150                 155                 160 


Asn Leu Ala Leu Ala Ala Ser Ala Ala Ala Val Asp Ala Gly Met Ala 
                165                 170                 175     


Met Ala Gly Gln Ser Pro Val Leu Arg Ile Ile Val Glu Asn Leu Phe 
            180                 185                 190         


Tyr Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys Phe Gly 
        195                 200                 205             


Thr Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe Gln Ala 
    210                 215                 220                 


Leu Leu Gln Tyr Ala Asp Pro Val Ser Ala Gln His Ala Lys Leu Ser 
225                 230                 235                 240 


Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg Ile Asp 
                245                 250                 255     


Phe Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser 
            260                 265                 270         


Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Ser Gln Pro Ser 
        275                 280                 285             


Leu Asp Gln Thr Met Ala Ala Ala Phe Ala Ser Pro Tyr Ala Gly Ala 
    290                 295                 300                 


Gly Phe Pro Pro Thr Phe Ala Ile Pro Gln Ala Ala Gly Leu Ser Val 
305                 310                 315                 320 


Pro Asn Val His Gly Ala Leu Ala Pro Leu Ala Ile Pro Ser Ala Ala 
                325                 330                 335     


Ala Ala Ala Ala Ala Ala Gly Arg Ile Ala Ile Pro Gly Leu Ala Gly 
            340                 345                 350         


Ala Gly Asn Ser Val Leu Leu Val Ser Asn Leu Asn Pro Glu Arg Val 
        355                 360                 365             


Thr Pro Gln Ser Leu Phe Ile Leu Phe Gly Val Tyr Gly Asp Val Gln 
    370                 375                 380                 


Arg Val Lys Ile Leu Phe Asn Lys Lys Glu Asn Ala Leu Val Gln Met 
385                 390                 395                 400 


Ala Asp Gly Asn Gln Ala Gln Leu Ala Met Ser His Leu Asn Gly His 
                405                 410                 415     


Lys Leu His Gly Lys Pro Ile Arg Ile Thr Leu Ser Lys His Gln Asn 
            420                 425                 430         


Val Gln Leu Pro Arg Glu Gly Gln Glu Asp Gln Gly Leu Thr Lys Asp 
        435                 440                 445             


Tyr Gly Asn Ser Pro Leu His Arg Phe Lys Lys Pro Gly Ser Lys Asn 
    450                 455                 460                 


Phe Gln Asn Ile Phe Pro Pro Ser Ala Thr Leu His Leu Ser Asn Ile 
465                 470                 475                 480 


Pro Pro Ser Val Ser Glu Glu Asp Leu Lys Val Leu Phe Ser Ser Asn 
                485                 490                 495     


Gly Gly Val Val Lys Gly Phe Lys Phe Phe Gln Lys Asp Arg Lys Met 
            500                 505                 510         


Ala Leu Ile Gln Met Gly Ser Val Glu Glu Ala Val Gln Ala Leu Ile 
        515                 520                 525             


Asp Leu His Asn His Asp Leu Gly Glu Asn His His Leu Arg Val Ser 
    530                 535                 540                 


Phe Ser Lys Ser Thr Ile 
545                 550 


<210> 321
<211> 3262
<212> DNA
<213> Homo sapiens

<400> 321
tgcgggcgtc tccgccattt tgtgagtcta taactcggag ccgttgggtc ggttcctgct       60

attccggcgc ctccactccg tcccccgcgg gtctgctctg tgtgccatgg acggcattgt      120

cccagatata gccgttggta caaagcgggg atctgacgag cttttctcta cttgtgtcac      180

taacggaccg tttatcatga gcagcaactc ggcttctgca gcaaacggaa atgacagcaa      240

gaagttcaaa ggtgacagcc gaagtgcagg cgtcccctct agagtgatcc acatccggaa      300

gctccccatc gacgtcacgg agggggaagt catctccctg gggctgccct ttgggaaggt      360

caccaacctc ctgatgctga aggggaaaaa ccaggccttc atcgagatga acacggagga      420

ggctgccaac accatggtga actactacac ctcggtgacc cctgtgctgc gcggccagcc      480

catctacatc cagttctcca accacaagga gctgaagacc gacagctctc ccaaccaggc      540

gcgggcccag gcggccctgc aggcggtgaa ctcggtccag tcggggaacc tggccttggc      600

tgcctcggcg gcggccgtgg acgcagggat ggcgatggcc gggcagagcc ccgtgctcag      660

gatcatcgtg gagaacctct tctaccctgt gaccctggat gtgctgcacc agattttctc      720

caagttcggc acagtgttga agatcatcac cttcaccaag aacaaccagt tccaggccct      780

gctgcagtat gcggaccccg tgagcgccca gcacgccaag ctgtcgctgg acgggcagaa      840

catctacaac gcctgctgca cgctgcgcat cgacttttcc aagctcacca gcctcaacgt      900

caagtacaac aatgacaaga gccgtgacta cacacgccca gacctgcctt ccggggacag      960

ccagccctcg ctggaccaga ccatggccgc ggccttcggc ctttccgttc cgaacgtcca     1020

cggcgccctg gcccccctgg ccatcccctc ggcggcggcg gcagctgcgg cggcaggtcg     1080

gatcgccatc ccgggcctgg cgggggcagg aaattctgta ttgctggtca gcaacctcaa     1140

cccagagaga gtcacacccc aaagcctctt tattcttttc ggcgtctacg gtgacgtgca     1200

gcgcgtgaag atcctgttca ataagaagga gaacgcccta gtgcagatgg cggacggcaa     1260

ccaggcccag ctggccatga gccacctgaa cgggcacaag ctgcacggga agcccatccg     1320

catcacgctc tcgaagcacc agaacgtgca gctgccccgc gagggccagg aggaccaggg     1380

cctgaccaag gactacggca actcacccct gcaccgcttc aagaagccgg gctccaagaa     1440

cttccagaac atattcccgc cctcggccac gctgcacctc tccaacatcc cgccctcagt     1500

ctccgaggag gatctcaagg tcctgttttc cagcaatggg ggcgtcgtca aaggattcaa     1560

gttcttccag aaggaccgca agatggcact gatccagatg ggctccgtgg aggaggcggt     1620

ccaggccctc attgacctgc acaaccacga cctcggggag aaccaccacc tgcgggtctc     1680

cttctccaag tccaccatct aggggcacag gcccccacgg ccgggccccc tggcgacaac     1740

ttccatcatt ccagagaaaa gccactttaa aaacagctga agtgacctta gcagaccaga     1800

gattttattt ttttaaagag aaatcagttt acctgttttt aaaaaaatta aatctagttc     1860

accttgctca ccctgcggtg acagggacag ctcaggctct tggtgactgt ggcagcggga     1920

gttcccggcc ctccacaccc ggggccagac cctcggggcc atgccttggt ggggcctgtg     1980

tcgggcgtgg ggcctgcagg tgggcgcccc gaccacgact tggcttcctt gtgccttaaa     2040

aaacctgcct tcctgcagcc acacacccac ccggggtgtc ctggggaccc aaggggtggg     2100

ggggtcacac cagagagagg cagggggcct ggccggctcc tgcaggatca tgcagctggg     2160

gcgcggcggc cgcggctgcg acaccccaac cccagccctc taatcaagtc acgtgattct     2220

cccttcaccc cgcccccagg gccttccctt ctgcccccag gcgggctccc cgctgctcca     2280

gctgcggagc tggtcgacat aatctctgta ttatatactt tgcagttgca gacgtctgtg     2340

cctagcaata tttccagttg accaaatatt ctaatctttt ttcatttata tgcaaaagaa     2400

atagttttaa gtaacttttt atagcaagat gatacaatgg tatgagtgta atctaaactt     2460

ccttgtggta ttaccttgta tgctgttact tttattttat tccttgtaat taagtcacag     2520

gcaggaccca gtttccagag agcaggcggg gccgcccagt gggtcaggca cagggagccc     2580

cggtcctatc ttagagcccc tgagcttcag ggaaggggcg ggcgtgtcgc cgcctctggc     2640

atcgcctccg gttgccttac accacgcctt cacctgcagt cgcctagaaa acttgctctc     2700

aaacttcagg gttttttctt ccttcaaatt ttggaccaaa gtctcatttc tgtgttttgc     2760

ctgcctctga tgctgggacc cggaaggcgg gcgctcctcc tgtcttctct gtgctctttc     2820

taccgccccc gcgtcctgtc ccgggggctc tcctaggatc ccctttccgt aaaagcgtgt     2880

aacaagggtg taaatattta taatttttta tacctgttgt gagacccgag gggcggcggc     2940

gcggtttttt atggtgacac aaatgtatat tttgctaaca gcaattccag gctcagtatt     3000

gtgaccgcgg agccacaggg gaccccacgc acattccgtt gccttacccg atggcttgtg     3060

acgcggagag aaccgattaa aaccgtttga gaaactcctc ccttgtctag ccctgtgttc     3120

gctgtggacg ctgtagaggc aggttggcca gtctgtacct ggacttcgaa taaatcttct     3180

gtatcctcgc tccgttccgc cttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3240

aaaaaaaaaa aaaaaaaaaa aa                                              3262


<210> 322
<211> 531
<212> PRT
<213> Homo sapiens

<400> 322
Met Asp Gly Ile Val Pro Asp Ile Ala Val Gly Thr Lys Arg Gly Ser 
1               5                   10                  15      


Asp Glu Leu Phe Ser Thr Cys Val Thr Asn Gly Pro Phe Ile Met Ser 
            20                  25                  30          


Ser Asn Ser Ala Ser Ala Ala Asn Gly Asn Asp Ser Lys Lys Phe Lys 
        35                  40                  45              


Gly Asp Ser Arg Ser Ala Gly Val Pro Ser Arg Val Ile His Ile Arg 
    50                  55                  60                  


Lys Leu Pro Ile Asp Val Thr Glu Gly Glu Val Ile Ser Leu Gly Leu 
65                  70                  75                  80  


Pro Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Asn Gln 
                85                  90                  95      


Ala Phe Ile Glu Met Asn Thr Glu Glu Ala Ala Asn Thr Met Val Asn 
            100                 105                 110         


Tyr Tyr Thr Ser Val Thr Pro Val Leu Arg Gly Gln Pro Ile Tyr Ile 
        115                 120                 125             


Gln Phe Ser Asn His Lys Glu Leu Lys Thr Asp Ser Ser Pro Asn Gln 
    130                 135                 140                 


Ala Arg Ala Gln Ala Ala Leu Gln Ala Val Asn Ser Val Gln Ser Gly 
145                 150                 155                 160 


Asn Leu Ala Leu Ala Ala Ser Ala Ala Ala Val Asp Ala Gly Met Ala 
                165                 170                 175     


Met Ala Gly Gln Ser Pro Val Leu Arg Ile Ile Val Glu Asn Leu Phe 
            180                 185                 190         


Tyr Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys Phe Gly 
        195                 200                 205             


Thr Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe Gln Ala 
    210                 215                 220                 


Leu Leu Gln Tyr Ala Asp Pro Val Ser Ala Gln His Ala Lys Leu Ser 
225                 230                 235                 240 


Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg Ile Asp 
                245                 250                 255     


Phe Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser 
            260                 265                 270         


Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Ser Gln Pro Ser 
        275                 280                 285             


Leu Asp Gln Thr Met Ala Ala Ala Phe Gly Leu Ser Val Pro Asn Val 
    290                 295                 300                 


His Gly Ala Leu Ala Pro Leu Ala Ile Pro Ser Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Gly Arg Ile Ala Ile Pro Gly Leu Ala Gly Ala Gly Asn 
                325                 330                 335     


Ser Val Leu Leu Val Ser Asn Leu Asn Pro Glu Arg Val Thr Pro Gln 
            340                 345                 350         


Ser Leu Phe Ile Leu Phe Gly Val Tyr Gly Asp Val Gln Arg Val Lys 
        355                 360                 365             


Ile Leu Phe Asn Lys Lys Glu Asn Ala Leu Val Gln Met Ala Asp Gly 
    370                 375                 380                 


Asn Gln Ala Gln Leu Ala Met Ser His Leu Asn Gly His Lys Leu His 
385                 390                 395                 400 


Gly Lys Pro Ile Arg Ile Thr Leu Ser Lys His Gln Asn Val Gln Leu 
                405                 410                 415     


Pro Arg Glu Gly Gln Glu Asp Gln Gly Leu Thr Lys Asp Tyr Gly Asn 
            420                 425                 430         


Ser Pro Leu His Arg Phe Lys Lys Pro Gly Ser Lys Asn Phe Gln Asn 
        435                 440                 445             


Ile Phe Pro Pro Ser Ala Thr Leu His Leu Ser Asn Ile Pro Pro Ser 
    450                 455                 460                 


Val Ser Glu Glu Asp Leu Lys Val Leu Phe Ser Ser Asn Gly Gly Val 
465                 470                 475                 480 


Val Lys Gly Phe Lys Phe Phe Gln Lys Asp Arg Lys Met Ala Leu Ile 
                485                 490                 495     


Gln Met Gly Ser Val Glu Glu Ala Val Gln Ala Leu Ile Asp Leu His 
            500                 505                 510         


Asn His Asp Leu Gly Glu Asn His His Leu Arg Val Ser Phe Ser Lys 
        515                 520                 525             


Ser Thr Ile 
    530     


<210> 323
<211> 3499
<212> DNA
<213> Homo sapiens

<400> 323
cggctcagag ctccggaccg cgggcggagg ggaggggcag ggggcggtgc cacggcctgc       60

cagcccgccc gcccgcccgc cagccagccc tccccgcggc cggctcggct ccttggcgct      120

gcctggggtc ctttccgccc ggtccccgct tgccagcccc cgctgctctg tgccctgtcc      180

ggccaggcct ggagccgaca ccaccgccat catgccggcc gtgtccaagg gcgatgggat      240

gcgggggctc gcggtgttca tctccgacat ccggaactgt aagagcaaag aggcggaaat      300

taagagaatc aacaaggaac tggccaacat ccgctccaag ttcaaaggag acaaagcctt      360

ggatggctac agtaagaaaa aatatgtgtg taaactgctt ttcatcttcc tgcttggcca      420

tgacattgac tttgggcaca tggaggctgt gaatctgttg agttccaata aatacacaga      480

gaagcaaata ggttacctgt tcatttctgt gctggtgaac tcgaactcgg agctgatccg      540

cctcatcaac aacgccatca agaatgacct ggccagccgc aaccccacct tcatgtgcct      600

ggccctgcac tgcatcgcca acgtgggcag ccgggagatg ggcgaggcct ttgccgctga      660

catcccccgc atcctggtgg ccggggacag catggacagt gtcaagcaga gtgcggccct      720

gtgcctcctt cgactgtaca aggcctcgcc tgacctggtg cccatgggcg agtggacggc      780

gcgtgtggta cacctgctca atgaccagca catgggtgtg gtcacggccg ccgtcagcct      840

catcacctgt ctctgcaaga agaacccaga tgacttcaag acgtgcgtct ctctggctgt      900

gtcgcgcctg agccggatcg tctcctctgc ctccaccgac ctccaggact acacctacta      960

cttcgtccca gcaccctggc tctcggtgaa gctcctgcgg ctgctgcagt gctacccgcc     1020

tccagaggat gcggctgtga aggggcggct ggtggaatgt ctggagactg tgctcaacaa     1080

ggcccaggag ccccccaaat ccaagaaggt gcagcattcc aacgccaaga acgccatcct     1140

cttcgagacc atcagcctca tcatccacta tgacagtgag cccaacctcc tggttcgggc     1200

ctgcaaccag ctgggccagt tcctgcagca ccgggagacc aacctgcgct acctggccct     1260

ggagagcatg tgcacgctgg ccagctccga gttctcccat gaagccgtca agacgcacat     1320

tgacaccgtc atcaatgccc tcaagacgga gcgggacgtc agcgtgcggc agcgggcggc     1380

tgacctcctc tacgccatgt gtgaccggag caatgccaag cagatcgtgt cggagatgct     1440

gcggtacctg gagacggcag actacgccat ccgcgaggag atcgtcctga aggtggccat     1500

cctggccgag aagtacgccg tggactacag ctggtacgtg gacaccatcc tcaacctcat     1560

ccgcattgcg ggcgactacg tgagtgagga ggtgtggtac cgtgtgctac agatcgtcac     1620

caaccgtgat gacgtccagg gctatgccgc caagaccgtc tttgaggcgc tccaggcccc     1680

tgcctgtcac gagaacatgg tgaaggttgg cggctacatc cttggggagt ttgggaacct     1740

gattgctggg gacccccgct ccagcccccc agtgcagttc tccctgctcc actccaagtt     1800

ccatctgtgc agcgtggcca cgcgggcgct gctgctgtcc acctacatca agttcatcaa     1860

cctcttcccc gagaccaagg ccaccatcca gggcgtcctg cgggccggct cccagctgcg     1920

caatgctgac gtggagctgc agcagcgagc cgtggagtac ctcaccctca gctcagtggc     1980

cagcaccgac gtcctggcca cggtgctgga ggagatgccg cccttccccg agcgcgagtc     2040

gtccatcctg gccaagctga aacgcaagaa ggggccaggg gccggcagcg ccctggacga     2100

tggccggagg gaccccagca gcaacgacat caacgggggc atggagccca cccccagcac     2160

tgtgtcgacg ccctcgccct ccgccgacct cctggggctg cgggcagccc ctcccccggc     2220

agcacccccg gcttctgcag gagcagggaa ccttctggtg gacgtcttcg atggcccggc     2280

cgcccagccc agcctggggc ccacccccga ggaggccttc ctcagcgagc tggagccgcc     2340

tgcccccgag agccccatgg ctttgctggc tgacccagct ccagctgctg acccaggtcc     2400

tgaggacatc ggccctccca ttccggaagc cgatgagttg ctgaataagt ttgtgtgtaa     2460

gaacaacggg gtcctgttcg agaaccagct gctgcagatc ggagtcaagt cagagttccg     2520

acagaacctg ggccgcatgt atctcttcta tggcaacaag acctcggtgc agttccagaa     2580

tttctcaccc actgtggttc acccgggaga cctccagact cagctggctg tgcagaccaa     2640

gcgcgtggcg gcgcaggtgg acggcggcgc gcaggtgcag caggtgctca atatcgagtg     2700

cctgcgggac ttcctgacgc ccccgctgct gtccgtgcgc ttccggtacg gtggcgcccc     2760

ccaggccctc accctgaagc tcccagtgac catcaacaag ttcttccagc ccaccgagat     2820

ggcggcccag gatttcttcc agcgctggaa gcagctgagc ctccctcaac aggaggcgca     2880

gaaaatcttc aaagccaacc accccatgga cgcagaagtt actaaggcca agcttctggg     2940

gtttggctct gctctcctgg acaatgtgga ccccaaccct gagaacttcg tgggggcggg     3000

gatcatccag actaaagccc tgcaggtggg ctgtctgctt cggctggagc ccaatgccca     3060

ggcccagatg taccggctga ccctgcgcac cagcaaggag cccgtctccc gtcacctgtg     3120

tgagctgctg gcacagcagt tctgagccct ggactctgcc ccgggggatg tggccggcac     3180

tgggcagccc cttggactga ggcagttttg gtggatgggg gacctccact ggtgacagag     3240

aagacaccag ggtttggggg atgcctggga ctttcctccg gccttttgta tttttatttt     3300

tgttcatctg ctgctgttta cattctgggg ggttaggggg agtccccctc cctccctttc     3360

ccccccaagc acagagggga gaggggccag ggaagtggat gtctcctccc ctcccacccc     3420

accctgttgt agcccctcct accccctccc catccagggg ctgtgtatta ttgtgagcga     3480

ataaacagag agacgctaa                                                  3499


<210> 324
<211> 977
<212> PRT
<213> Homo sapiens

<400> 324
Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
    50                  55                  60                  


Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
65                  70                  75                  80  


Asn Leu Leu Ser Ser Asn Lys Tyr Thr Glu Lys Gln Ile Gly Tyr Leu 
                85                  90                  95      


Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
            100                 105                 110         


Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Thr Phe Met 
        115                 120                 125             


Cys Leu Ala Leu His Cys Ile Ala Asn Val Gly Ser Arg Glu Met Gly 
    130                 135                 140                 


Glu Ala Phe Ala Ala Asp Ile Pro Arg Ile Leu Val Ala Gly Asp Ser 
145                 150                 155                 160 


Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                165                 170                 175     


Lys Ala Ser Pro Asp Leu Val Pro Met Gly Glu Trp Thr Ala Arg Val 
            180                 185                 190         


Val His Leu Leu Asn Asp Gln His Met Gly Val Val Thr Ala Ala Val 
        195                 200                 205             


Ser Leu Ile Thr Cys Leu Cys Lys Lys Asn Pro Asp Asp Phe Lys Thr 
    210                 215                 220                 


Cys Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Ser Ser Ala 
225                 230                 235                 240 


Ser Thr Asp Leu Gln Asp Tyr Thr Tyr Tyr Phe Val Pro Ala Pro Trp 
                245                 250                 255     


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Glu 
            260                 265                 270         


Asp Ala Ala Val Lys Gly Arg Leu Val Glu Cys Leu Glu Thr Val Leu 
        275                 280                 285             


Asn Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn 
    290                 295                 300                 


Ala Lys Asn Ala Ile Leu Phe Glu Thr Ile Ser Leu Ile Ile His Tyr 
305                 310                 315                 320 


Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln 
                325                 330                 335     


Phe Leu Gln His Arg Glu Thr Asn Leu Arg Tyr Leu Ala Leu Glu Ser 
            340                 345                 350         


Met Cys Thr Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Thr 
        355                 360                 365             


His Ile Asp Thr Val Ile Asn Ala Leu Lys Thr Glu Arg Asp Val Ser 
    370                 375                 380                 


Val Arg Gln Arg Ala Ala Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser 
385                 390                 395                 400 


Asn Ala Lys Gln Ile Val Ser Glu Met Leu Arg Tyr Leu Glu Thr Ala 
                405                 410                 415     


Asp Tyr Ala Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala 
            420                 425                 430         


Glu Lys Tyr Ala Val Asp Tyr Ser Trp Tyr Val Asp Thr Ile Leu Asn 
        435                 440                 445             


Leu Ile Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg 
    450                 455                 460                 


Val Leu Gln Ile Val Thr Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala 
465                 470                 475                 480 


Lys Thr Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Met 
                485                 490                 495     


Val Lys Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala 
            500                 505                 510         


Gly Asp Pro Arg Ser Ser Pro Pro Val Gln Phe Ser Leu Leu His Ser 
        515                 520                 525             


Lys Phe His Leu Cys Ser Val Ala Thr Arg Ala Leu Leu Leu Ser Thr 
    530                 535                 540                 


Tyr Ile Lys Phe Ile Asn Leu Phe Pro Glu Thr Lys Ala Thr Ile Gln 
545                 550                 555                 560 


Gly Val Leu Arg Ala Gly Ser Gln Leu Arg Asn Ala Asp Val Glu Leu 
                565                 570                 575     


Gln Gln Arg Ala Val Glu Tyr Leu Thr Leu Ser Ser Val Ala Ser Thr 
            580                 585                 590         


Asp Val Leu Ala Thr Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg 
        595                 600                 605             


Glu Ser Ser Ile Leu Ala Lys Leu Lys Arg Lys Lys Gly Pro Gly Ala 
    610                 615                 620                 


Gly Ser Ala Leu Asp Asp Gly Arg Arg Asp Pro Ser Ser Asn Asp Ile 
625                 630                 635                 640 


Asn Gly Gly Met Glu Pro Thr Pro Ser Thr Val Ser Thr Pro Ser Pro 
                645                 650                 655     


Ser Ala Asp Leu Leu Gly Leu Arg Ala Ala Pro Pro Pro Ala Ala Pro 
            660                 665                 670         


Pro Ala Ser Ala Gly Ala Gly Asn Leu Leu Val Asp Val Phe Asp Gly 
        675                 680                 685             


Pro Ala Ala Gln Pro Ser Leu Gly Pro Thr Pro Glu Glu Ala Phe Leu 
    690                 695                 700                 


Ser Glu Leu Glu Pro Pro Ala Pro Glu Ser Pro Met Ala Leu Leu Ala 
705                 710                 715                 720 


Asp Pro Ala Pro Ala Ala Asp Pro Gly Pro Glu Asp Ile Gly Pro Pro 
                725                 730                 735     


Ile Pro Glu Ala Asp Glu Leu Leu Asn Lys Phe Val Cys Lys Asn Asn 
            740                 745                 750         


Gly Val Leu Phe Glu Asn Gln Leu Leu Gln Ile Gly Val Lys Ser Glu 
        755                 760                 765             


Phe Arg Gln Asn Leu Gly Arg Met Tyr Leu Phe Tyr Gly Asn Lys Thr 
    770                 775                 780                 


Ser Val Gln Phe Gln Asn Phe Ser Pro Thr Val Val His Pro Gly Asp 
785                 790                 795                 800 


Leu Gln Thr Gln Leu Ala Val Gln Thr Lys Arg Val Ala Ala Gln Val 
                805                 810                 815     


Asp Gly Gly Ala Gln Val Gln Gln Val Leu Asn Ile Glu Cys Leu Arg 
            820                 825                 830         


Asp Phe Leu Thr Pro Pro Leu Leu Ser Val Arg Phe Arg Tyr Gly Gly 
        835                 840                 845             


Ala Pro Gln Ala Leu Thr Leu Lys Leu Pro Val Thr Ile Asn Lys Phe 
    850                 855                 860                 


Phe Gln Pro Thr Glu Met Ala Ala Gln Asp Phe Phe Gln Arg Trp Lys 
865                 870                 875                 880 


Gln Leu Ser Leu Pro Gln Gln Glu Ala Gln Lys Ile Phe Lys Ala Asn 
                885                 890                 895     


His Pro Met Asp Ala Glu Val Thr Lys Ala Lys Leu Leu Gly Phe Gly 
            900                 905                 910         


Ser Ala Leu Leu Asp Asn Val Asp Pro Asn Pro Glu Asn Phe Val Gly 
        915                 920                 925             


Ala Gly Ile Ile Gln Thr Lys Ala Leu Gln Val Gly Cys Leu Leu Arg 
    930                 935                 940                 


Leu Glu Pro Asn Ala Gln Ala Gln Met Tyr Arg Leu Thr Leu Arg Thr 
945                 950                 955                 960 


Ser Lys Glu Pro Val Ser Arg His Leu Cys Glu Leu Leu Ala Gln Gln 
                965                 970                 975     


Phe 
    


<210> 325
<211> 3433
<212> DNA
<213> Homo sapiens

<400> 325
cggctcagag ctccggaccg cgggcggagg ggaggggcag ggggcggtgc cacggcctgc       60

cagcccgccc gcccgcccgc cagccagccc tccccgcggc cggctcggct ccttggcgct      120

gcctggggtc ctttccgccc ggtccccgct tgccagcccc cgctgctctg tgccctgtcc      180

ggccaggcct ggagccgaca ccaccgccat catgccggcc gtgtccaagg gcgatgggat      240

gcgggggctc gcggtgttca tctccgacat ccggaactgt aagagcaaag aggcggaaat      300

taagagaatc aacaaggaac tggccaacat ccgctccaag ttcaaaggag acaaagcctt      360

ggatggctac agtaagaaaa aatatgtgtg taaactgctt ttcatcttcc tgcttggcca      420

tgacattgac tttgggcaca tggaggctgt gaatctgttg agttccaata aatacacaga      480

gaagcaaata ggttacctgt tcatttctgt gctggtgaac tcgaactcgg agctgatccg      540

cctcatcaac aacgccatca agaatgacct ggccagccgc aaccccacct tcatgtgcct      600

ggccctgcac tgcatcgcca acgtgggcag ccgggagatg ggcgaggcct ttgccgctga      660

catcccccgc atcctggtgg ccggggacag catggacagt gtcaagcaga gtgcggccct      720

gtgcctcctt cgactgtaca aggcctcgcc tgacctggtg cccatgggcg agtggacggc      780

gcgtgtggta cacctgctca atgaccagca catgggtgtg gtcacggccg ccgtcagcct      840

catcacctgt ctctgcaaga agaacccaga tgacttcaag acgtgcgtct ctctggctgt      900

gtcgcgcctg agccggatcg tctcctctgc ctccaccgac ctccaggact acacctacta      960

cttcgtccca gcaccctggc tctcggtgaa gctcctgcgg ctgctgcagt gctacccgcc     1020

tccagaggat gcggctgtga aggggcggct ggtggaatgt ctggagactg tgctcaacaa     1080

ggcccaggag ccccccaaat ccaagaaggt gcagcattcc aacgccaaga acgccatcct     1140

cttcgagacc atcagcctca tcatccacta tgacagtgag cccaacctcc tggttcgggc     1200

ctgcaaccag ctgggccagt tcctgcagca ccgggagacc aacctgcgct acctggccct     1260

ggagagcatg tgcacgctgg ccagctccga gttctcccat gaagccgtca agacgcacat     1320

tgacaccgtc atcaatgccc tcaagacgga gcgggacgtc agcgtgcggc agcgggcggc     1380

tgacctcctc tacgccatgt gtgaccggag caatgccaag cagatcgtgt cggagatgct     1440

gcggtacctg gagacggcag actacgccat ccgcgaggag atcgtcctga aggtggccat     1500

cctggccgag aagtacgccg tggactacag ctggtacgtg gacaccatcc tcaacctcat     1560

ccgcattgcg ggcgactacg tgagtgagga ggtgtggtac cgtgtgctac agatcgtcac     1620

caaccgtgat gacgtccagg gctatgccgc caagaccgtc tttgaggcgc tccaggcccc     1680

tgcctgtcac gagaacatgg tgaaggttgg cggctacatc cttggggagt ttgggaacct     1740

gattgctggg gacccccgct ccagcccccc agtgcagttc tccctgctcc actccaagtt     1800

ccatctgtgc agcgtggcca cgcgggcgct gctgctgtcc acctacatca agttcatcaa     1860

cctcttcccc gagaccaagg ccaccatcca gggcgtcctg cgggccggct cccagctgcg     1920

caatgctgac gtggagctgc agcagcgagc cgtggagtac ctcaccctca gctcagtggc     1980

cagcaccgac gtcctggcca cggtgctgga ggagatgccg cccttccccg agcgcgagtc     2040

gtccatcctg gccaagctga aacgcaagaa ggggccaggg gccggcagcg ccctggacga     2100

tggccggagg gaccccagca gcaacgacat caacgggggc atggagccca cccccagcac     2160

tgtgtcgacg ccctcgccct ccgccgacct cctggggctg cgggcagccc ctcccccggc     2220

agcacccccg gcttctgcag gagcagggaa ccttctggtg gacgtcttcg atggcccggc     2280

cgcccagccc agcctggggc ccacccccga ggaggccttc ctcagcccag gtcctgagga     2340

catcggccct cccattccgg aagccgatga gttgctgaat aagtttgtgt gtaagaacaa     2400

cggggtcctg ttcgagaacc agctgctgca gatcggagtc aagtcagagt tccgacagaa     2460

cctgggccgc atgtatctct tctatggcaa caagacctcg gtgcagttcc agaatttctc     2520

acccactgtg gttcacccgg gagacctcca gactcagctg gctgtgcaga ccaagcgcgt     2580

ggcggcgcag gtggacggcg gcgcgcaggt gcagcaggtg ctcaatatcg agtgcctgcg     2640

ggacttcctg acgcccccgc tgctgtccgt gcgcttccgg tacggtggcg ccccccaggc     2700

cctcaccctg aagctcccag tgaccatcaa caagttcttc cagcccaccg agatggcggc     2760

ccaggatttc ttccagcgct ggaagcagct gagcctccct caacaggagg cgcagaaaat     2820

cttcaaagcc aaccacccca tggacgcaga agttactaag gccaagcttc tggggtttgg     2880

ctctgctctc ctggacaatg tggaccccaa ccctgagaac ttcgtggggg cggggatcat     2940

ccagactaaa gccctgcagg tgggctgtct gcttcggctg gagcccaatg cccaggccca     3000

gatgtaccgg ctgaccctgc gcaccagcaa ggagcccgtc tcccgtcacc tgtgtgagct     3060

gctggcacag cagttctgag ccctggactc tgccccgggg gatgtggccg gcactgggca     3120

gccccttgga ctgaggcagt tttggtggat gggggacctc cactggtgac agagaagaca     3180

ccagggtttg ggggatgcct gggactttcc tccggccttt tgtattttta tttttgttca     3240

tctgctgctg tttacattct ggggggttag ggggagtccc cctccctccc tttccccccc     3300

aagcacagag gggagagggg ccagggaagt ggatgtctcc tcccctccca ccccaccctg     3360

ttgtagcccc tcctaccccc tccccatcca ggggctgtgt attattgtga gcgaataaac     3420

agagagacgc taa                                                        3433


<210> 326
<211> 955
<212> PRT
<213> Homo sapiens

<400> 326
Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
    50                  55                  60                  


Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
65                  70                  75                  80  


Asn Leu Leu Ser Ser Asn Lys Tyr Thr Glu Lys Gln Ile Gly Tyr Leu 
                85                  90                  95      


Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
            100                 105                 110         


Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Thr Phe Met 
        115                 120                 125             


Cys Leu Ala Leu His Cys Ile Ala Asn Val Gly Ser Arg Glu Met Gly 
    130                 135                 140                 


Glu Ala Phe Ala Ala Asp Ile Pro Arg Ile Leu Val Ala Gly Asp Ser 
145                 150                 155                 160 


Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                165                 170                 175     


Lys Ala Ser Pro Asp Leu Val Pro Met Gly Glu Trp Thr Ala Arg Val 
            180                 185                 190         


Val His Leu Leu Asn Asp Gln His Met Gly Val Val Thr Ala Ala Val 
        195                 200                 205             


Ser Leu Ile Thr Cys Leu Cys Lys Lys Asn Pro Asp Asp Phe Lys Thr 
    210                 215                 220                 


Cys Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Ser Ser Ala 
225                 230                 235                 240 


Ser Thr Asp Leu Gln Asp Tyr Thr Tyr Tyr Phe Val Pro Ala Pro Trp 
                245                 250                 255     


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Glu 
            260                 265                 270         


Asp Ala Ala Val Lys Gly Arg Leu Val Glu Cys Leu Glu Thr Val Leu 
        275                 280                 285             


Asn Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn 
    290                 295                 300                 


Ala Lys Asn Ala Ile Leu Phe Glu Thr Ile Ser Leu Ile Ile His Tyr 
305                 310                 315                 320 


Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln 
                325                 330                 335     


Phe Leu Gln His Arg Glu Thr Asn Leu Arg Tyr Leu Ala Leu Glu Ser 
            340                 345                 350         


Met Cys Thr Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Thr 
        355                 360                 365             


His Ile Asp Thr Val Ile Asn Ala Leu Lys Thr Glu Arg Asp Val Ser 
    370                 375                 380                 


Val Arg Gln Arg Ala Ala Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser 
385                 390                 395                 400 


Asn Ala Lys Gln Ile Val Ser Glu Met Leu Arg Tyr Leu Glu Thr Ala 
                405                 410                 415     


Asp Tyr Ala Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala 
            420                 425                 430         


Glu Lys Tyr Ala Val Asp Tyr Ser Trp Tyr Val Asp Thr Ile Leu Asn 
        435                 440                 445             


Leu Ile Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg 
    450                 455                 460                 


Val Leu Gln Ile Val Thr Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala 
465                 470                 475                 480 


Lys Thr Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Met 
                485                 490                 495     


Val Lys Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala 
            500                 505                 510         


Gly Asp Pro Arg Ser Ser Pro Pro Val Gln Phe Ser Leu Leu His Ser 
        515                 520                 525             


Lys Phe His Leu Cys Ser Val Ala Thr Arg Ala Leu Leu Leu Ser Thr 
    530                 535                 540                 


Tyr Ile Lys Phe Ile Asn Leu Phe Pro Glu Thr Lys Ala Thr Ile Gln 
545                 550                 555                 560 


Gly Val Leu Arg Ala Gly Ser Gln Leu Arg Asn Ala Asp Val Glu Leu 
                565                 570                 575     


Gln Gln Arg Ala Val Glu Tyr Leu Thr Leu Ser Ser Val Ala Ser Thr 
            580                 585                 590         


Asp Val Leu Ala Thr Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg 
        595                 600                 605             


Glu Ser Ser Ile Leu Ala Lys Leu Lys Arg Lys Lys Gly Pro Gly Ala 
    610                 615                 620                 


Gly Ser Ala Leu Asp Asp Gly Arg Arg Asp Pro Ser Ser Asn Asp Ile 
625                 630                 635                 640 


Asn Gly Gly Met Glu Pro Thr Pro Ser Thr Val Ser Thr Pro Ser Pro 
                645                 650                 655     


Ser Ala Asp Leu Leu Gly Leu Arg Ala Ala Pro Pro Pro Ala Ala Pro 
            660                 665                 670         


Pro Ala Ser Ala Gly Ala Gly Asn Leu Leu Val Asp Val Phe Asp Gly 
        675                 680                 685             


Pro Ala Ala Gln Pro Ser Leu Gly Pro Thr Pro Glu Glu Ala Phe Leu 
    690                 695                 700                 


Ser Pro Gly Pro Glu Asp Ile Gly Pro Pro Ile Pro Glu Ala Asp Glu 
705                 710                 715                 720 


Leu Leu Asn Lys Phe Val Cys Lys Asn Asn Gly Val Leu Phe Glu Asn 
                725                 730                 735     


Gln Leu Leu Gln Ile Gly Val Lys Ser Glu Phe Arg Gln Asn Leu Gly 
            740                 745                 750         


Arg Met Tyr Leu Phe Tyr Gly Asn Lys Thr Ser Val Gln Phe Gln Asn 
        755                 760                 765             


Phe Ser Pro Thr Val Val His Pro Gly Asp Leu Gln Thr Gln Leu Ala 
    770                 775                 780                 


Val Gln Thr Lys Arg Val Ala Ala Gln Val Asp Gly Gly Ala Gln Val 
785                 790                 795                 800 


Gln Gln Val Leu Asn Ile Glu Cys Leu Arg Asp Phe Leu Thr Pro Pro 
                805                 810                 815     


Leu Leu Ser Val Arg Phe Arg Tyr Gly Gly Ala Pro Gln Ala Leu Thr 
            820                 825                 830         


Leu Lys Leu Pro Val Thr Ile Asn Lys Phe Phe Gln Pro Thr Glu Met 
        835                 840                 845             


Ala Ala Gln Asp Phe Phe Gln Arg Trp Lys Gln Leu Ser Leu Pro Gln 
    850                 855                 860                 


Gln Glu Ala Gln Lys Ile Phe Lys Ala Asn His Pro Met Asp Ala Glu 
865                 870                 875                 880 


Val Thr Lys Ala Lys Leu Leu Gly Phe Gly Ser Ala Leu Leu Asp Asn 
                885                 890                 895     


Val Asp Pro Asn Pro Glu Asn Phe Val Gly Ala Gly Ile Ile Gln Thr 
            900                 905                 910         


Lys Ala Leu Gln Val Gly Cys Leu Leu Arg Leu Glu Pro Asn Ala Gln 
        915                 920                 925             


Ala Gln Met Tyr Arg Leu Thr Leu Arg Thr Ser Lys Glu Pro Val Ser 
    930                 935                 940                 


Arg His Leu Cys Glu Leu Leu Ala Gln Gln Phe 
945                 950                 955 


<210> 327
<211> 3421
<212> DNA
<213> Homo sapiens

<400> 327
gccgacggac ggcgggcggc ggcggcggtg gcggcgctgg agtcggcgcg ggtgctggcg       60

ccatggaggc cgagcggggt cccgagcgcc ggcctgcgga gcgtagcagc ccgggccaga      120

cgccggagga gggcgcgcag gccttggccg agttcgcggc gctgcacggc ccggcgctgc      180

gcgcttcggg ggtccccgaa cgttactggg gccgcctcct gcacaagctg gagcacgagg      240

ttttcgacgc tggggaagtg tttgggatca tgcaagtgga ggaggtagaa gaggaggagg      300

acgaggcagc ccgggaggtg cggaagcagc agcccaaccc ggggaacgag ctgtgctaca      360

aggtcatcgt gaccagggag agcgggctcc aggcagccca ccccaacagc atcttcctca      420

tcgaccacgc ctggacgtgc cgtgtggagc acgcgcgcca gcagctgcag caggtgcccg      480

ggctgctgca ccgcatggcc aacctgatgg gcattgagtt ccacggtgag ctgcccagta      540

cagaggctgt ggccctggtg ctggaggaga tgtggaagtt caaccagacc taccagctgg      600

cccatgggac agctgaggag aagatgccgg tgtggtatat catggacgag ttcggttcgc      660

ggatccagca cgcggacgtg cccagcttcg ccacggcacc cttcttctac atgccgcagc      720

aggtggccta cacgctgctg tggcccctga gggacctgga cactggcgag gaggtgaccc      780

gagactttgc ctacggagag acggaccccc tgatccggaa gtgcatgctg ctgccctggg      840

cccccaccga catgctggac ctcagctctt gcacacccga gccgcccgcc gagcactacc      900

aggccattct ggaggaaaac aaggagaagc tgccacttga catcaacccc gtggtgcacc      960

cccacggcca catcttcaag gtctacacgg acgtgcagca ggtggccagc agcctcaccc     1020

acccgcgctt caccctcacc cagagtgagg cggacgccga catcctcttc aacttctcac     1080

acttcaagga ctacaggaaa ctcagccagg agaggccagg cgtgctgctg aaccagttcc     1140

cctgcgagaa cctgctgact gtcaaggact gcctggcctc catcgcgcgc cgggcaggtg     1200

gccccgaggg cccaccctgg ctgccccgaa ccttcaacct gcgcactgag ctgccccagt     1260

ttgtcagcta cttccagcag cgggaaaggt ggggcgagga caaccactgg atctgcaagc     1320

cctggaacct ggcgcgcagc ctggacaccc acgtcaccaa gagcctgcac agcatcatcc     1380

ggcaccgaga gagcaccccc aaggttgtgt ccaagtacat cgaaagtccc gtgttgttcc     1440

ttcgagaaga cgtgggaaag gtcaagttcg acatccgcta catcgtgctg ctgcggtcag     1500

tgaggcccct acggttgttc gtgtatgatg tgttctggct gcggttctcc aaccgggcct     1560

ttgcactcaa cgacctggat gactacgaga agcacttcac ggtcatgaac tatgacccgg     1620

atgtggtgct gaagcaggtg cactgtgaag agttcatccc cgagtttgag aagcaatacc     1680

cagaatttcc ctggacggac gtccaggctg agatcttccg ggccttcacg gagctgttcc     1740

aggtggcctg tgccaagcca ccacccctgg gcctctgcga ctacccctca tcccgggcca     1800

tgtatgccgt cgacctcatg ctgaagtggg acaacggccc agatggaagg cgggtgatgc     1860

agccgcagat cctggaggtg aacttcaacc ccgactgtga gcgagcctgc aggtaccacc     1920

ccaccttctt caacgacgtc ttcagcacct tgtttctgga ccagcccggt ggctgccacg     1980

ttacctgcct tgtctaggca ctcgctgtcc ccaaaacctg tgcttggggc aggattccaa     2040

cctcagttct ctgagctgct tctgcaaagg cccccatgtc cctccccaca ccggccctgg     2100

gcatagcctc agccccaggc ctctgtcctg ccgagccatc ctcccggcgc cacactccgg     2160

gagcacagca tcctcctctc acctgtgggt cagagcagga cagtgatggt gtccccaggg     2220

ctgagcacca ccccacgccc tgccctcacc cctcaccacc atctgtgcac tgatgagtct     2280

ccagtttagc caagggcttt gttcctggca tggagaattt gttcctggct gctgtgtttc     2340

cagggggtgc tgggggaagg gttccgtgga gcgagacaag gtgtcctcgg gagcagggtt     2400

ccaccgggaa gcgtttggga gccctgtatc acacggggca ggcgggtttc tcttccgggg     2460

tctctgctct tatgcatcag gacgaccccg ggacggctgt ggggccccac actgcaccca     2520

cagggctcta tgcgacaggg gcccaggaac agcctgaggc caccacccag caagcccgcc     2580

ttatcaccca ttccagctca cccagaacct tcaccagcaa acctcctgct gaggtcctgg     2640

caggaggcca ccgtcttgtt accgtttcct tttcgtttgc tgagggtcac agaccccaac     2700

agggaaatca gtatctgtct tcccagtggt tgccctgctc gccgggcact ccacggggtc     2760

ccgcccttgt gtgagatggg ccaggatcct tcggcaaggg gcgcctgggg ctggggctga     2820

ttgtgggcgg tggagcgcca gacagaaaag gattccaatg agaacttcag gttaaagtca     2880

gatgccacct accagggtct acagtcaaaa tgttggcttt ttcttatttt ttaatgtatg     2940

ggagaaaaat gtaaaattcc agttcttttc taattgtgtt tctgaaatta ggagtcagct     3000

gccagcgttt ttgtgtggct gcagtgtgcc tgggcccagc tcacgggcag tgggtggacc     3060

taactgccca ggcaggcgag agctacttcc agagccttcc agtgcatggg agggcagggc     3120

taggtgtagc ggtgtctcct ctttgaaatt aagaactatc tttcttgtag caaagctgca     3180

cctgatgatg ctgcctctcc tctctgtgtt gtctgggccc ttgtttacaa gcacgcgtta     3240

cccttcctga ggggagccat gctctagccc ctggagggcc tgttgcaggg gcagggcggg     3300

cccgtcgcct ttggcagctc ctggagagct gtggacatgc agtccccctc agttcgtgct     3360

gcaataaagg ccatcttctc ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3420

a                                                                     3421


<210> 328
<211> 644
<212> PRT
<213> Homo sapiens

<400> 328
Met Glu Ala Glu Arg Gly Pro Glu Arg Arg Pro Ala Glu Arg Ser Ser 
1               5                   10                  15      


Pro Gly Gln Thr Pro Glu Glu Gly Ala Gln Ala Leu Ala Glu Phe Ala 
            20                  25                  30          


Ala Leu His Gly Pro Ala Leu Arg Ala Ser Gly Val Pro Glu Arg Tyr 
        35                  40                  45              


Trp Gly Arg Leu Leu His Lys Leu Glu His Glu Val Phe Asp Ala Gly 
    50                  55                  60                  


Glu Val Phe Gly Ile Met Gln Val Glu Glu Val Glu Glu Glu Glu Asp 
65                  70                  75                  80  


Glu Ala Ala Arg Glu Val Arg Lys Gln Gln Pro Asn Pro Gly Asn Glu 
                85                  90                  95      


Leu Cys Tyr Lys Val Ile Val Thr Arg Glu Ser Gly Leu Gln Ala Ala 
            100                 105                 110         


His Pro Asn Ser Ile Phe Leu Ile Asp His Ala Trp Thr Cys Arg Val 
        115                 120                 125             


Glu His Ala Arg Gln Gln Leu Gln Gln Val Pro Gly Leu Leu His Arg 
    130                 135                 140                 


Met Ala Asn Leu Met Gly Ile Glu Phe His Gly Glu Leu Pro Ser Thr 
145                 150                 155                 160 


Glu Ala Val Ala Leu Val Leu Glu Glu Met Trp Lys Phe Asn Gln Thr 
                165                 170                 175     


Tyr Gln Leu Ala His Gly Thr Ala Glu Glu Lys Met Pro Val Trp Tyr 
            180                 185                 190         


Ile Met Asp Glu Phe Gly Ser Arg Ile Gln His Ala Asp Val Pro Ser 
        195                 200                 205             


Phe Ala Thr Ala Pro Phe Phe Tyr Met Pro Gln Gln Val Ala Tyr Thr 
    210                 215                 220                 


Leu Leu Trp Pro Leu Arg Asp Leu Asp Thr Gly Glu Glu Val Thr Arg 
225                 230                 235                 240 


Asp Phe Ala Tyr Gly Glu Thr Asp Pro Leu Ile Arg Lys Cys Met Leu 
                245                 250                 255     


Leu Pro Trp Ala Pro Thr Asp Met Leu Asp Leu Ser Ser Cys Thr Pro 
            260                 265                 270         


Glu Pro Pro Ala Glu His Tyr Gln Ala Ile Leu Glu Glu Asn Lys Glu 
        275                 280                 285             


Lys Leu Pro Leu Asp Ile Asn Pro Val Val His Pro His Gly His Ile 
    290                 295                 300                 


Phe Lys Val Tyr Thr Asp Val Gln Gln Val Ala Ser Ser Leu Thr His 
305                 310                 315                 320 


Pro Arg Phe Thr Leu Thr Gln Ser Glu Ala Asp Ala Asp Ile Leu Phe 
                325                 330                 335     


Asn Phe Ser His Phe Lys Asp Tyr Arg Lys Leu Ser Gln Glu Arg Pro 
            340                 345                 350         


Gly Val Leu Leu Asn Gln Phe Pro Cys Glu Asn Leu Leu Thr Val Lys 
        355                 360                 365             


Asp Cys Leu Ala Ser Ile Ala Arg Arg Ala Gly Gly Pro Glu Gly Pro 
    370                 375                 380                 


Pro Trp Leu Pro Arg Thr Phe Asn Leu Arg Thr Glu Leu Pro Gln Phe 
385                 390                 395                 400 


Val Ser Tyr Phe Gln Gln Arg Glu Arg Trp Gly Glu Asp Asn His Trp 
                405                 410                 415     


Ile Cys Lys Pro Trp Asn Leu Ala Arg Ser Leu Asp Thr His Val Thr 
            420                 425                 430         


Lys Ser Leu His Ser Ile Ile Arg His Arg Glu Ser Thr Pro Lys Val 
        435                 440                 445             


Val Ser Lys Tyr Ile Glu Ser Pro Val Leu Phe Leu Arg Glu Asp Val 
    450                 455                 460                 


Gly Lys Val Lys Phe Asp Ile Arg Tyr Ile Val Leu Leu Arg Ser Val 
465                 470                 475                 480 


Arg Pro Leu Arg Leu Phe Val Tyr Asp Val Phe Trp Leu Arg Phe Ser 
                485                 490                 495     


Asn Arg Ala Phe Ala Leu Asn Asp Leu Asp Asp Tyr Glu Lys His Phe 
            500                 505                 510         


Thr Val Met Asn Tyr Asp Pro Asp Val Val Leu Lys Gln Val His Cys 
        515                 520                 525             


Glu Glu Phe Ile Pro Glu Phe Glu Lys Gln Tyr Pro Glu Phe Pro Trp 
    530                 535                 540                 


Thr Asp Val Gln Ala Glu Ile Phe Arg Ala Phe Thr Glu Leu Phe Gln 
545                 550                 555                 560 


Val Ala Cys Ala Lys Pro Pro Pro Leu Gly Leu Cys Asp Tyr Pro Ser 
                565                 570                 575     


Ser Arg Ala Met Tyr Ala Val Asp Leu Met Leu Lys Trp Asp Asn Gly 
            580                 585                 590         


Pro Asp Gly Arg Arg Val Met Gln Pro Gln Ile Leu Glu Val Asn Phe 
        595                 600                 605             


Asn Pro Asp Cys Glu Arg Ala Cys Arg Tyr His Pro Thr Phe Phe Asn 
    610                 615                 620                 


Asp Val Phe Ser Thr Leu Phe Leu Asp Gln Pro Gly Gly Cys His Val 
625                 630                 635                 640 


Thr Cys Leu Val 
                


<210> 329
<211> 3372
<212> DNA
<213> Homo sapiens

<400> 329
gggtggagcg cggggagcca ggcgaggggc cgcgacgacg ggactccatt agccgctccg       60

gccacaggca gcgcttcgcc agccgaggaa ccggacgcgg acaccgccgc cccgcgagcc      120

tccagcccct cgcctgttgc cgcgcgagtc ccgggcccgg agcgctagga gcgcgcggaa      180

ggagccatgg ctctggacgg gataaggatg ccagatggct gctacgcgga cgggacgtgg      240

gaactgagtg tccatgtgac ggacctgaac cgcgatgtca ccctgagagt gaccggcgag      300

gtgcacattg gaggcgtgat gcttaagctg gtggagaaac tcgatgtaaa aaaagattgg      360

tctgaccatg ctctctggtg ggaaaagaag agaacttggc ttctgaagac acattggacc      420

ttagataagt atggtattca ggcagatgct aagcttcagt tcacccctca gcacaaactg      480

ctccgcctgc agcttcccaa catgaagtat gtgaaggtga aagtgaattt ctctgataga      540

gtcttcaaag ctgtttctga catctgtaag acttttaata tcagacaccc cgaagaactt      600

tctctcttaa agaaacccag agatccaaca aagaaaaaaa agaagaagct agatgaccag      660

tctgaagatg aggcacttga attagagggg cctcttatca ctcctggatc aggaagtata      720

tattcaagcc caggactgta tagtaaaaca atgaccccca cttatgatgc tcatgatgga      780

agccccttgt caccaacttc tgcttggttt ggtgacagtg ctttgtcaga aggcaatcct      840

ggtatacttg ctgtcagtca accaatcacg tcaccagaaa tcttggcaaa aatgttcaag      900

cctcaagctc ttcttgataa agcaaaaatc aaccaaggat ggcttgattc ctcaagatct      960

ctcatggaac aagatgtgaa ggaaaatgag gccttgctgc tccgattcaa gtattacagc     1020

ttttttgatt tgaatccaaa gtatgatgca atcagaatca atcagcttta cgagcaggcc     1080

aaatgggcca ttctcctgga agagattgaa tgcacagaag aagaaatgat gatgtttgca     1140

gccctgcagt atcatatcaa taagctgtca atcatgacat cagagaatca tttgaacaac     1200

agtgacaaag aagttgatga agttgatgct gccctttcag acctggagat tactctggaa     1260

gggggtaaaa cgtcaacaat tttgggtgac attacttcca ttcctgaact tgctgactac     1320

attaaagttt tcaagccaaa aaagctgact ctgaaaggtt acaaacaata ttggtgcacc     1380

ttcaaagaca catccatttc ttgttataag agcaaagaag aatccagtgg cacaccagct     1440

catcagatga acctcagggg atgtgaagtt accccagatg taaacatttc aggccaaaaa     1500

tttaacatta aactcctgat tccagttgca gaaggcatga atgaaatctg gcttcgttgt     1560

gacaatgaaa aacagtatgc acactggatg gcagcctgca gattagcctc caaaggcaag     1620

accatggcgg acagttctta caacttagaa gttcagaata ttctttcctt tctgaagatg     1680

cagcatttaa acccagatcc tcagttaata ccagagcaga tcacgactga tataactcct     1740

gaatgtttgg tgtctccccg ctatctaaaa aagtataaga acaagcagcc aggctatata     1800

agagatttga taacagcgag aatcttggag gcccatcaga atgtagctca gatgagtcta     1860

attgaagcca agatgagatt tattcaagct tggcagtcac tacctgaatt tggcatcact     1920

cacttcattg caaggttcca agggggcaaa aaagaagaac ttattggaat tgcatacaac     1980

agactgattc ggatggatgc cagcactgga gatgcaatta aaacatggcg tttcagcaac     2040

atgaaacagt ggaatgtcaa ctgggaaatc aaaatggtca ccgtagagtt tgcagatgaa     2100

gtacgattgt ccttcatttg tactgaagta gattgcaaag tggttcatga attcattggt     2160

ggctacatat ttctctcaac acgtgcaaaa gaccaaaacg agagtttaga tgaagagatg     2220

ttctacaaac ttaccagtgg ttgggtgtga ataggaatac tgtttaatga aactccacgg     2280

ccataacaat atttaacttt aaaagctgtt tgttatatgc tgcttaataa agtaagcttg     2340

aaatttatca ttttatcatg aaaacttctt tgccttacca gaccagttaa tatgtgcact     2400

aaacaagcac gactattaat ctatcatgtt atgatataat aaacttgaat ttgtcacaca     2460

ttccttaggg ccatgaattg aaaactgaaa tagtgggcaa atcaggaaca aaccatcact     2520

gatttactga tttaagctag ccaaactgta agaaacaagc catctatttt aaagctatcc     2580

agggcttaac ctatatgaac tctatttatc atgtctaatg catgtgattt aatgtatgtt     2640

taatttgata tcatgtttta aaatatccta cttctggtag ccatttaatt cctcccccta     2700

cccccaaata aatcaggcat gcaggaggcc tgatatttag taatgtcatt gtgtttgacc     2760

ttgaaggaaa atgctattag tccgtcgtgc ttgatttgtt tttgtccttg aataagcatg     2820

ttatgtatat tgtctcgtgt ttttattttt acaccatatt gtattacact tttagtattc     2880

accagcataa tcactgtctg cctaaaatat gcaactcttt gcattacaat atgaagtaaa     2940

gttctatgaa gtatgcattt tgtgtaacta atgtaaaaac acaaatttta taaaattgta     3000

cagtttttta aaaactactc acaactagca gatggcttaa atgtagcaat ctctgcgtta     3060

attaaatgcc tttaagagat ataattaacg tgcagtttta atatctacta aattaagaat     3120

gacttcatta tgatcatgat ttgccacaat gtccttaact ctaatgcctg gactggccat     3180

gttctagtct gttgcgctgt tacaatctgt attggtgcta gtcagaaaat tcctagctca     3240

catagcccaa aagggtgcga gggagaggtg gattaccagt attgttcaat aatccatggt     3300

tcaaagactg tataaatgca ttttatttta aataaaagca aaacttttat ttaataaaaa     3360

aaaaaaaaaa aa                                                         3372


<210> 330
<211> 687
<212> PRT
<213> Homo sapiens

<400> 330
Met Ala Leu Asp Gly Ile Arg Met Pro Asp Gly Cys Tyr Ala Asp Gly 
1               5                   10                  15      


Thr Trp Glu Leu Ser Val His Val Thr Asp Leu Asn Arg Asp Val Thr 
            20                  25                  30          


Leu Arg Val Thr Gly Glu Val His Ile Gly Gly Val Met Leu Lys Leu 
        35                  40                  45              


Val Glu Lys Leu Asp Val Lys Lys Asp Trp Ser Asp His Ala Leu Trp 
    50                  55                  60                  


Trp Glu Lys Lys Arg Thr Trp Leu Leu Lys Thr His Trp Thr Leu Asp 
65                  70                  75                  80  


Lys Tyr Gly Ile Gln Ala Asp Ala Lys Leu Gln Phe Thr Pro Gln His 
                85                  90                  95      


Lys Leu Leu Arg Leu Gln Leu Pro Asn Met Lys Tyr Val Lys Val Lys 
            100                 105                 110         


Val Asn Phe Ser Asp Arg Val Phe Lys Ala Val Ser Asp Ile Cys Lys 
        115                 120                 125             


Thr Phe Asn Ile Arg His Pro Glu Glu Leu Ser Leu Leu Lys Lys Pro 
    130                 135                 140                 


Arg Asp Pro Thr Lys Lys Lys Lys Lys Lys Leu Asp Asp Gln Ser Glu 
145                 150                 155                 160 


Asp Glu Ala Leu Glu Leu Glu Gly Pro Leu Ile Thr Pro Gly Ser Gly 
                165                 170                 175     


Ser Ile Tyr Ser Ser Pro Gly Leu Tyr Ser Lys Thr Met Thr Pro Thr 
            180                 185                 190         


Tyr Asp Ala His Asp Gly Ser Pro Leu Ser Pro Thr Ser Ala Trp Phe 
        195                 200                 205             


Gly Asp Ser Ala Leu Ser Glu Gly Asn Pro Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Gln Pro Ile Thr Ser Pro Glu Ile Leu Ala Lys Met Phe Lys Pro Gln 
225                 230                 235                 240 


Ala Leu Leu Asp Lys Ala Lys Ile Asn Gln Gly Trp Leu Asp Ser Ser 
                245                 250                 255     


Arg Ser Leu Met Glu Gln Asp Val Lys Glu Asn Glu Ala Leu Leu Leu 
            260                 265                 270         


Arg Phe Lys Tyr Tyr Ser Phe Phe Asp Leu Asn Pro Lys Tyr Asp Ala 
        275                 280                 285             


Ile Arg Ile Asn Gln Leu Tyr Glu Gln Ala Lys Trp Ala Ile Leu Leu 
    290                 295                 300                 


Glu Glu Ile Glu Cys Thr Glu Glu Glu Met Met Met Phe Ala Ala Leu 
305                 310                 315                 320 


Gln Tyr His Ile Asn Lys Leu Ser Ile Met Thr Ser Glu Asn His Leu 
                325                 330                 335     


Asn Asn Ser Asp Lys Glu Val Asp Glu Val Asp Ala Ala Leu Ser Asp 
            340                 345                 350         


Leu Glu Ile Thr Leu Glu Gly Gly Lys Thr Ser Thr Ile Leu Gly Asp 
        355                 360                 365             


Ile Thr Ser Ile Pro Glu Leu Ala Asp Tyr Ile Lys Val Phe Lys Pro 
    370                 375                 380                 


Lys Lys Leu Thr Leu Lys Gly Tyr Lys Gln Tyr Trp Cys Thr Phe Lys 
385                 390                 395                 400 


Asp Thr Ser Ile Ser Cys Tyr Lys Ser Lys Glu Glu Ser Ser Gly Thr 
                405                 410                 415     


Pro Ala His Gln Met Asn Leu Arg Gly Cys Glu Val Thr Pro Asp Val 
            420                 425                 430         


Asn Ile Ser Gly Gln Lys Phe Asn Ile Lys Leu Leu Ile Pro Val Ala 
        435                 440                 445             


Glu Gly Met Asn Glu Ile Trp Leu Arg Cys Asp Asn Glu Lys Gln Tyr 
    450                 455                 460                 


Ala His Trp Met Ala Ala Cys Arg Leu Ala Ser Lys Gly Lys Thr Met 
465                 470                 475                 480 


Ala Asp Ser Ser Tyr Asn Leu Glu Val Gln Asn Ile Leu Ser Phe Leu 
                485                 490                 495     


Lys Met Gln His Leu Asn Pro Asp Pro Gln Leu Ile Pro Glu Gln Ile 
            500                 505                 510         


Thr Thr Asp Ile Thr Pro Glu Cys Leu Val Ser Pro Arg Tyr Leu Lys 
        515                 520                 525             


Lys Tyr Lys Asn Lys Gln Pro Gly Tyr Ile Arg Asp Leu Ile Thr Ala 
    530                 535                 540                 


Arg Ile Leu Glu Ala His Gln Asn Val Ala Gln Met Ser Leu Ile Glu 
545                 550                 555                 560 


Ala Lys Met Arg Phe Ile Gln Ala Trp Gln Ser Leu Pro Glu Phe Gly 
                565                 570                 575     


Ile Thr His Phe Ile Ala Arg Phe Gln Gly Gly Lys Lys Glu Glu Leu 
            580                 585                 590         


Ile Gly Ile Ala Tyr Asn Arg Leu Ile Arg Met Asp Ala Ser Thr Gly 
        595                 600                 605             


Asp Ala Ile Lys Thr Trp Arg Phe Ser Asn Met Lys Gln Trp Asn Val 
    610                 615                 620                 


Asn Trp Glu Ile Lys Met Val Thr Val Glu Phe Ala Asp Glu Val Arg 
625                 630                 635                 640 


Leu Ser Phe Ile Cys Thr Glu Val Asp Cys Lys Val Val His Glu Phe 
                645                 650                 655     


Ile Gly Gly Tyr Ile Phe Leu Ser Thr Arg Ala Lys Asp Gln Asn Glu 
            660                 665                 670         


Ser Leu Asp Glu Glu Met Phe Tyr Lys Leu Thr Ser Gly Trp Val 
        675                 680                 685         


<210> 331
<211> 3002
<212> DNA
<213> Homo sapiens

<400> 331
agaggggtgg ggtggaggag ggaggcgggc gcgccggatt ggcctctgcg cgccacgtgt       60

ccggctcgga gcccacggct gtcctcccgg tccgccccgc gctgcggttg ctgctgggct      120

aacgggctcc gatccagcga gcgctgcgtc ctcgagtccc tgcgcccgtg cgtccgtctg      180

cgacccgagg cctccgctgc gcgtggattc tgctgcgaac cggagaccat ggccaaacca      240

gcacagggtg ccaagtaccg gggctccatc catgacttcc caggctttga ccccaaccag      300

gatgccgagg ctctgtacac tgccatgaag ggctttggca gtgacaagga ggccatactg      360

gacataatca cctcacggag caacaggcag aggcaggagg tctgccagag ctacaagtcc      420

ctctacggca aggacctcat tgctgattta aagtatgaat tgacgggcaa gtttgaacgg      480

ttgattgtgg gcctgatgag gccacctgcc tattgtgatg ccaaagaaat taaagatgcc      540

atctcgggca ttggcactga tgagaagtgc ctcattgaga tcttggcttc ccggaccaat      600

gagcagatgc accagctggt ggcagcatac aaagatgcct acgagcggga cctggaggct      660

gacatcatcg gcgacacctc tggccacttc cagaagatgc ttgtggtcct gctccaggga      720

accagggagg aggatgacgt agtgagcgag gacctggtac aacaggatgt ccaggaccta      780

tacgaggcag gggaactgaa atggggaaca gatgaagccc agttcattta catcttggga      840

aatcgcagca agcagcatct tcggttggtg ttcgatgagt atctgaagac cacagggaag      900

ccgattgaag ccagcatccg aggggagctg tctggggact ttgagaagct aatgctggcc      960

gtagtgaagt gtatccggag caccccggaa tattttgctg aaaggctctt caaggctatg     1020

aagggcctgg ggactcggga caacaccctg atccgcatca tggtctcccg tagtgagttg     1080

gacatgctcg acattcggga gatcttccgg accaagtatg agaagtccct ctacagcatg     1140

atcaagaatg acacctctgg cgagtacaag aagactctgc tgaagctgtc tgggggagat     1200

gatgatgctg ctggccagtt cttcccggag gcagcgcagg tggcctatca gatgtgggaa     1260

cttagtgcag tggcccgagt agagctgaag ggaactgtgc gcccagccaa tgacttcaac     1320

cctgacgcag atgccaaagc gctgcggaaa gccatgaagg gactcgggac tgacgaagac     1380

acaatcatcg atatcatcac gcaccgcagc aatgtccagc ggcagcagat ccggcagacc     1440

ttcaagtctc actttggccg ggacttaatg actgacctga agtctgagat ctctggagac     1500

ctggcaaggc tgattctggg gctcatgatg ccaccggccc attacgatgc caagcagttg     1560

aagaaggcca tggagggagc cggcacagat gaaaaggctc ttattgaaat cctggccact     1620

cggaccaatg ctgaaatccg ggccatcaat gaggcctata aggaggacta tcacaagtcc     1680

ctggaggatg ctctgagctc agacacatct ggccacttca ggaggatcct catttctctg     1740

gccacggggc atcgtgagga gggaggagaa aacctggacc aggcacggga agatgcccag     1800

gtggctgctg agatcttgga aatagcagac acacctagtg gagacaaaac ttccttggag     1860

acacgtttca tgacgatcct gtgtacccgg agctatccgc acctccggag agtcttccag     1920

gagttcatca agatgaccaa ctatgacgtg gagcacacca tcaagaagga gatgtctggg     1980

gatgtcaggg atgcatttgt ggccattgtt caaagtgtca agaacaagcc tctcttcttt     2040

gccgacaaac tttacaaatc catgaagggt gctggcacag atgagaagac tctgaccagg     2100

atcatggtat cccgcagtga gattgacctg ctcaacatcc ggagggaatt cattgagaaa     2160

tatgacaagt ctctccacca agccattgag ggtgacacct ccggagactt cctgaaggcc     2220

ttgctggctc tctgtggtgg tgaggactag ggccacagct ttggcgggca cttctgccaa     2280

gaaatggtta tcagcaccag ccgccatggc caagcctgat tgttccagct ccagagacta     2340

aggaaggggc aggggtgggg ggaggggttg ggttgggctc ttatcttcag tggagcttag     2400

gaaacgctcc cactcccacg ggccatcgag ggcccagcac ggctgagcgg ctgaaaaacc     2460

gtagccatag atcctgtcca cctccactcc cctctgaccc tcaggctttc ccagcttcct     2520

ccccttgcta cagcctctgc cctggtttgg gctatgtcag atccaaaaac atcctgaacc     2580

tctgtctgta aaatgagtag tgtctgtact ttgaatgagg gggttggtgg caggggccag     2640

ttgaatgtgc tgggcggggt ggtgggaagg atagtaaatg tgctggggca aactgacaaa     2700

tcttcccatc catttcacca cccatctcca tccaggccgc gctagagtac tggaccagga     2760

atttggatgc ctgggttcaa atctgcatct gccatgcact tgtttctgac cttaggccag     2820

cccctttccc tccctgagtc tctattttct tatctacaat gagacagttg gacaaaaaaa     2880

tcttggcttc ccttctaaca ttaacttcct aaagtatgcc tccgattcat tcccttgaca     2940

ctttttattt ctaaggaaga aataaaaaga gatacacaaa cacataaaca caaaaaaaaa     3000

aa                                                                    3002


<210> 332
<211> 673
<212> PRT
<213> Homo sapiens

<400> 332
Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp 
    


<210> 333
<211> 1332
<212> DNA
<213> Homo sapiens

<400> 333
aattggagga gttgttgtta ggccgtcccg gagacccggt cgggagggag gaaggtggca       60

agatggtgtt ggaaagcact atggtgtgtg tggacaacag tgagtatatg cggaatggag      120

acttcttacc caccaggctg caggcccagc aggatgctgt caacatagtt tgtcattcaa      180

agacccgcag caaccctgag aacaacgtgg gccttatcac actggctaat gactgtgaag      240

tgctgaccac actcacccca gacactggcc gtatcctgtc caagctacat actgtccaac      300

ccaagggcaa gatcaccttc tgcacgggca tccgcgtggc ccatctggct ctgaagcacc      360

gacaaggcaa gaatcacaag atgcgcatca ttgcctttgt gggaagccca gtggaggaca      420

atgagaagga tctggtgaaa ctggctaaac gcctcaagaa ggagaaagta aatgttgaca      480

ttatcaattt tggggaagag gaggtgaaca cagaaaagct gacagccttt gtaaacacgt      540

tgaatggcaa agatggaacc ggttctcatc tggtgacagt gcctcctggg cccagtttgg      600

ctgatgctct catcagttct ccgattttgg ctggtgaagg tggtgccatg ctgggtcttg      660

gtgccagtga ctttgaattt ggagtagatc ccagtgctga tcctgagctg gccttggccc      720

ttcgtgtatc tatggaagag cagcggcagc ggcaggagga ggaggcccgg cgggcagctg      780

cagcttctgc tgctgaggcc gggattgcta cgactgggac tgaagactca gacgatgccc      840

tgctgaagat gaccatcagc cagcaagagt ttggccgcac tgggcttcct gacctaagca      900

gtatgactga ggaagagcag attgcttatg ccatgcagat gtccctgcag ggagcagagt      960

ttggccaggc ggaatcagca gacattgatg ccagctcagc tatggacaca tctgagccag     1020

ccaaggagga ggatgattac gacgtgatgc aggaccccga gttccttcag agtgtcctag     1080

agaacctccc aggtgtggat cccaacaatg aagccattcg aaatgctatg ggctccctgg     1140

cctcccaggc caccaaggac ggcaagaagg acaagaagga ggaagacaag aagtgagact     1200

ggagggaaag ggtagctgag tctgcttagg ggactgcatg ggaagcacgg aatatagggt     1260

tagatgtgtg ttatctgtaa ccattacagc ctaaataaag cttggcaact ttttttcctt     1320

ttttgcttca aa                                                         1332


<210> 334
<211> 377
<212> PRT
<213> Homo sapiens

<400> 334
Met Val Leu Glu Ser Thr Met Val Cys Val Asp Asn Ser Glu Tyr Met 
1               5                   10                  15      


Arg Asn Gly Asp Phe Leu Pro Thr Arg Leu Gln Ala Gln Gln Asp Ala 
            20                  25                  30          


Val Asn Ile Val Cys His Ser Lys Thr Arg Ser Asn Pro Glu Asn Asn 
        35                  40                  45              


Val Gly Leu Ile Thr Leu Ala Asn Asp Cys Glu Val Leu Thr Thr Leu 
    50                  55                  60                  


Thr Pro Asp Thr Gly Arg Ile Leu Ser Lys Leu His Thr Val Gln Pro 
65                  70                  75                  80  


Lys Gly Lys Ile Thr Phe Cys Thr Gly Ile Arg Val Ala His Leu Ala 
                85                  90                  95      


Leu Lys His Arg Gln Gly Lys Asn His Lys Met Arg Ile Ile Ala Phe 
            100                 105                 110         


Val Gly Ser Pro Val Glu Asp Asn Glu Lys Asp Leu Val Lys Leu Ala 
        115                 120                 125             


Lys Arg Leu Lys Lys Glu Lys Val Asn Val Asp Ile Ile Asn Phe Gly 
    130                 135                 140                 


Glu Glu Glu Val Asn Thr Glu Lys Leu Thr Ala Phe Val Asn Thr Leu 
145                 150                 155                 160 


Asn Gly Lys Asp Gly Thr Gly Ser His Leu Val Thr Val Pro Pro Gly 
                165                 170                 175     


Pro Ser Leu Ala Asp Ala Leu Ile Ser Ser Pro Ile Leu Ala Gly Glu 
            180                 185                 190         


Gly Gly Ala Met Leu Gly Leu Gly Ala Ser Asp Phe Glu Phe Gly Val 
        195                 200                 205             


Asp Pro Ser Ala Asp Pro Glu Leu Ala Leu Ala Leu Arg Val Ser Met 
    210                 215                 220                 


Glu Glu Gln Arg Gln Arg Gln Glu Glu Glu Ala Arg Arg Ala Ala Ala 
225                 230                 235                 240 


Ala Ser Ala Ala Glu Ala Gly Ile Ala Thr Thr Gly Thr Glu Asp Ser 
                245                 250                 255     


Asp Asp Ala Leu Leu Lys Met Thr Ile Ser Gln Gln Glu Phe Gly Arg 
            260                 265                 270         


Thr Gly Leu Pro Asp Leu Ser Ser Met Thr Glu Glu Glu Gln Ile Ala 
        275                 280                 285             


Tyr Ala Met Gln Met Ser Leu Gln Gly Ala Glu Phe Gly Gln Ala Glu 
    290                 295                 300                 


Ser Ala Asp Ile Asp Ala Ser Ser Ala Met Asp Thr Ser Glu Pro Ala 
305                 310                 315                 320 


Lys Glu Glu Asp Asp Tyr Asp Val Met Gln Asp Pro Glu Phe Leu Gln 
                325                 330                 335     


Ser Val Leu Glu Asn Leu Pro Gly Val Asp Pro Asn Asn Glu Ala Ile 
            340                 345                 350         


Arg Asn Ala Met Gly Ser Leu Ala Ser Gln Ala Thr Lys Asp Gly Lys 
        355                 360                 365             


Lys Asp Lys Lys Glu Glu Asp Lys Lys 
    370                 375         


<210> 335
<211> 1850
<212> DNA
<213> Homo sapiens

<400> 335
cgcgctcgca gctcgcaggc gccgcgtagc cgtcgccacc gccgccagcc cgtgcgccct       60

cggcgcgtac ccgccgcgct cccatccccg ccgccggcca ggggcgcgct cggccgcccc      120

ggacagtgtc ccgctgcggc tccgcggcga tggccaccaa gatcgacaaa gaggcttgcc      180

gggcggcgta caacctggtg cgcgacgacg gctcggccgt catctgggtg acttttaaat      240

atgacggctc caccatcgtc cccggcgagc agggagcgga gtaccagcac ttcatccagc      300

agtgcacaga tgacgtccgg ttgtttgcct tcgtgcgctt caccaccggg gatgccatga      360

gcaagaggtc caagtttgcc ctcatcacgt ggatcggtga gaacgtcagc gggctgcagc      420

gcgccaaaac cgggacggac aagaccctgg tgaaggaggt cgtacagaat ttcgctaagg      480

agtttgtgat cagtgatcgg aaggagctgg aggaagattt catcaagagc gagctgaaga      540

aggcgggggg agccaattac gacgcccaga cggagtaacc ccagcccccg ccacaccacc      600

ccttgccaaa gtcatctgcc tgctccccgg gggagaggac cgccggcctc agctactagc      660

ccaccagccc accagggaga aaagaagcca tgagaggcag cgcccgccac cctgtgtcca      720

cagcccccac cttcccgctt cccttagaac cctgccgtgt cctatctcat gacgctcatg      780

gaacctcttt ctttgatctt ctttttcttt tctccccctc ttttttgttc taaagaaaag      840

tcattttgat gcaaggtcct gcctgccatc agatccgagg tgcctcctgc agtgacccct      900

tttcctggca tttctcttcc acgcgacgag gtctgcctag tgagatctgc atgacctcac      960

gttgctttcc agagcccggg cctattttgc catctcagtt ttcctggacc ctgcttcctg     1020

tgtaccactg aggggcagct gggccaggag ctgtgcccgg tgcctgcagc cttcataagc     1080

acacacgtcc attccctact aaggcccaga cctcctggta tctgccccgg gctccctcat     1140

cccacctcca tccggagttg cctaagatgc atgtccagca taggcaggat tgctcggtgg     1200

tgagaaggtt aggtccggct cagactgaat aagaagagat aaaatttgcc ttaaaactta     1260

cctggcagtg gctttgctgc acggtctgaa accacctgtt cccaccctct tgaccgaaat     1320

ttccttgtga cacagagaag ggcaaaggtc tgagcccaga gttgacggag ggagtatttc     1380

agggttcact tcaggggctc ccaaagcgac aagatcgtta gggagagagg cccagggtgg     1440

ggactgggaa tttaaggaga gctgggaacg gatcccttag gttcaggaag cttctgtgta     1500

agctgcgagg atggcttggg ccgaagggtt gctctgcccg ccgcgctagc tgtgagctga     1560

gcaaagccct gggctcacag caccccaaaa gcctgtggct tcagtcctgc gtctgcacca     1620

cacattcaaa aggatcgttt tgttttgttt ttaaagaaag gtgagattgg cttggttctt     1680

catgagcaca tttgatatag ctctttttct gtttttcctt gctcatttcg ttttggggaa     1740

gaaatctgta ctgtattggg attgtaaaga acatctctgc actcagacag tttacagaaa     1800

taaatgtttt ttttgttttt cagaaaaaaa aaaaaaaaaa aaaaaaaaaa                1850


<210> 336
<211> 142
<212> PRT
<213> Homo sapiens

<400> 336
Met Ala Thr Lys Ile Asp Lys Glu Ala Cys Arg Ala Ala Tyr Asn Leu 
1               5                   10                  15      


Val Arg Asp Asp Gly Ser Ala Val Ile Trp Val Thr Phe Lys Tyr Asp 
            20                  25                  30          


Gly Ser Thr Ile Val Pro Gly Glu Gln Gly Ala Glu Tyr Gln His Phe 
        35                  40                  45              


Ile Gln Gln Cys Thr Asp Asp Val Arg Leu Phe Ala Phe Val Arg Phe 
    50                  55                  60                  


Thr Thr Gly Asp Ala Met Ser Lys Arg Ser Lys Phe Ala Leu Ile Thr 
65                  70                  75                  80  


Trp Ile Gly Glu Asn Val Ser Gly Leu Gln Arg Ala Lys Thr Gly Thr 
                85                  90                  95      


Asp Lys Thr Leu Val Lys Glu Val Val Gln Asn Phe Ala Lys Glu Phe 
            100                 105                 110         


Val Ile Ser Asp Arg Lys Glu Leu Glu Glu Asp Phe Ile Lys Ser Glu 
        115                 120                 125             


Leu Lys Lys Ala Gly Gly Ala Asn Tyr Asp Ala Gln Thr Glu 
    130                 135                 140         


<210> 337
<211> 3214
<212> DNA
<213> Homo sapiens

<400> 337
gggtgggagg agccagcggc cggggaggtt ctagtctgtt ctgtcttgcg gcagccgccc       60

ccttctgcgc ggtcacgccg agccagcgcc tgggcctgga accgggccgt agccccccca      120

gtttcgccca ccacctccct accatggacc cccgcaaagt gaacgagctt cgggcctttg      180

tgaaaatgtg taagcaggat ccgagcgttc tgcacaccga ggaaatgcgc ttcctgaggg      240

agtgggtgga gagcatgggt ggtaaagtac cacctgctac tcagaaagct aaatcagaag      300

aaaataccaa ggaagaaaaa cctgatagta agaaggtgga ggaagactta aaggcagacg      360

aaccatcaag tgaggaaagt gatctagaaa ttgataaaga aggtgtgatt gaaccagaca      420

ctgatgctcc tcaagaaatg ggagatgaaa atgcggagat aacggaggag atgatggatc      480

aggcaaatga taaaaaagtg gctgctattg aagccctaaa tgatggtgaa ctccagaaag      540

ccattgactt attcacagat gccatcaagc tgaatcctcg cttggccatt ttgtatgcca      600

agagggccag tgtcttcgtc aaattacaga agccaaatgc tgccatccga gactgtgaca      660

gagccattga aataaatcct gattcagctc agccttacaa gtggcggggg aaagcacaca      720

gacttctagg ccactgggaa gaagcagccc atgatcttgc ccttgcctgt aaattggatt      780

atgatgaaga tgctagtgca atgctgaaag aagttcaacc tagggcacag aaaattgcag      840

aacatcggag aaagtatgag cgaaaacgtg aagagcgaga gatcaaagaa agaatagaac      900

gagttaagaa ggctcgagaa gagcatgaga gagcccagag ggaggaagaa gccagacgac      960

agtcaggagc tcagtatggc tcttttccag gtggctttcc tgggggaatg cctggtaatt     1020

ttcccggagg aatgcctgga atgggagggg gcatgcctgg aatggctgga atgcctggac     1080

tcaatgaaat tcttagtgat ccagaggttc ttgcagccat gcaggatcca gaagttatgg     1140

tggctttcca ggatgtggct cagaacccag caaatatgtc aaaataccag agcaacccaa     1200

aggttatgaa tctcatcagt aaattgtcag ccaaatttgg aggtcaagcg taatgtcctt     1260

ctgataaata aagcccttgc tgaaggaaaa gcaacctaga tcaccttatg gatgtcgcaa     1320

taatacaaac cagtgtacct ctgaccttct catcaagaga gctggggtgc tttgaagata     1380

atccctaccc ctctccccca aatgcagctg aagcatttta cagtggtttg ccattagggt     1440

attcattcag ataatgtttt cctactagga attacaaact ttaaacactt tttaaatctt     1500

caaaatattt aaaacaaatt taaagggcct gttaattctt atatttttct ttactaatca     1560

ttttggattt ttttctttga attattggca gggaatatac ttatgtatgg aagattactg     1620

ctctgagtga aataaaagtt attagtgcga ggcaaacata actcatttga ggataaagtt     1680

tgtgttggat atgtggttcc tgatgcattt tgacttgtct ttttaaatgc tttatctttt     1740

tctttaaaga tttatttcaa taaaactaat tgggaccacc cgtatttcag taggacctgg     1800

gtagggattg gaagtacttg gcagggcagc agcaatcttg ctgtgtttga tataacatgc     1860

atccttgggc aggttgccct taaatcttac actgtggtga agggatgttt tttttgtaat     1920

gctgcagtag agttggagta cttagttctc ttgttgtcca gtatatctaa taagtgtttt     1980

tcatattatt tccacgtaag ggaaataagg tagtactttt ctttttatat ttctatgctt     2040

aaaattctct ttcctagtca aaaattgccc aaatctgtgt ttgctttctg cttgctacat     2100

ttgtctccct tacttttctt gagctaaaga caggcttttt ccaccggcat catcactgct     2160

atcatcatta acagcgtaat tatacaagca tatttaatgc tgagtttaat ttaatatgta     2220

atacatatgg taattgtagg gtaataccca caacaactgt agtttcttac ttggccaaga     2280

gaatgcttat ttaagtgtta gacttccatt ctggcaaaat cttgccttat cagaagacat     2340

tggaaagagg gattcccttt ggtgtttggt cttctactta gaaaaaccta ttgcagttag     2400

tttatcttgt agtattcatc tttgtattct gaagataagg tttgaattaa attgatacac     2460

acagagggga accgattttt tttatccaat gtgaattata aatgagataa tccacagtta     2520

ttcattgtgg agttgttgag actatgaaag actcattgtc tttgtattca gctcttaaat     2580

agtgtaacta tatccccacc tctgcttgct ttctttccct cccctccaat gataaagaaa     2640

atgataaatt ttctgttgtg cattcaattc ttattttaaa taagactaag tataggcatt     2700

gtacctgaca ttgctacgtt tctaccagtg tttcaattta aagtgctagt gtttaaaaac     2760

attttcaagg gataaggcct tctgtacttt gcttatttga agaatcagtg gtaggagcag     2820

tgaagtaaat tctatggagt acatttctaa aataccacat ttctgaaatc ataaataagt     2880

ttattcaggt tctaaccctt tgctgtacac aagcagacag aaatgcatct gttacataaa     2940

tgagaaaaag ctattatgct gatggagcat gctttttaaa tcctttaaaa acactcacca     3000

tataaacttg catttgagct tgtgtgttct tttgttaatg tgtagagttc tcctttctcg     3060

aaattgccag tgtgtacttg gcttaactca agaacagttt cttctggatt ccttatttga     3120

tttatttaac ctaattatat tctaatattg caaatattac cataagtggg taaaagtaaa     3180

attcctcttc tgaaaaaaaa aaaaaaaaaa aaaa                                 3214


<210> 338
<211> 369
<212> PRT
<213> Homo sapiens

<400> 338
Met Asp Pro Arg Lys Val Asn Glu Leu Arg Ala Phe Val Lys Met Cys 
1               5                   10                  15      


Lys Gln Asp Pro Ser Val Leu His Thr Glu Glu Met Arg Phe Leu Arg 
            20                  25                  30          


Glu Trp Val Glu Ser Met Gly Gly Lys Val Pro Pro Ala Thr Gln Lys 
        35                  40                  45              


Ala Lys Ser Glu Glu Asn Thr Lys Glu Glu Lys Pro Asp Ser Lys Lys 
    50                  55                  60                  


Val Glu Glu Asp Leu Lys Ala Asp Glu Pro Ser Ser Glu Glu Ser Asp 
65                  70                  75                  80  


Leu Glu Ile Asp Lys Glu Gly Val Ile Glu Pro Asp Thr Asp Ala Pro 
                85                  90                  95      


Gln Glu Met Gly Asp Glu Asn Ala Glu Ile Thr Glu Glu Met Met Asp 
            100                 105                 110         


Gln Ala Asn Asp Lys Lys Val Ala Ala Ile Glu Ala Leu Asn Asp Gly 
        115                 120                 125             


Glu Leu Gln Lys Ala Ile Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn 
    130                 135                 140                 


Pro Arg Leu Ala Ile Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys 
145                 150                 155                 160 


Leu Gln Lys Pro Asn Ala Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu 
                165                 170                 175     


Ile Asn Pro Asp Ser Ala Gln Pro Tyr Lys Trp Arg Gly Lys Ala His 
            180                 185                 190         


Arg Leu Leu Gly His Trp Glu Glu Ala Ala His Asp Leu Ala Leu Ala 
        195                 200                 205             


Cys Lys Leu Asp Tyr Asp Glu Asp Ala Ser Ala Met Leu Lys Glu Val 
    210                 215                 220                 


Gln Pro Arg Ala Gln Lys Ile Ala Glu His Arg Arg Lys Tyr Glu Arg 
225                 230                 235                 240 


Lys Arg Glu Glu Arg Glu Ile Lys Glu Arg Ile Glu Arg Val Lys Lys 
                245                 250                 255     


Ala Arg Glu Glu His Glu Arg Ala Gln Arg Glu Glu Glu Ala Arg Arg 
            260                 265                 270         


Gln Ser Gly Ala Gln Tyr Gly Ser Phe Pro Gly Gly Phe Pro Gly Gly 
        275                 280                 285             


Met Pro Gly Asn Phe Pro Gly Gly Met Pro Gly Met Gly Gly Gly Met 
    290                 295                 300                 


Pro Gly Met Ala Gly Met Pro Gly Leu Asn Glu Ile Leu Ser Asp Pro 
305                 310                 315                 320 


Glu Val Leu Ala Ala Met Gln Asp Pro Glu Val Met Val Ala Phe Gln 
                325                 330                 335     


Asp Val Ala Gln Asn Pro Ala Asn Met Ser Lys Tyr Gln Ser Asn Pro 
            340                 345                 350         


Lys Val Met Asn Leu Ile Ser Lys Leu Ser Ala Lys Phe Gly Gly Gln 
        355                 360                 365             


Ala 
    


<210> 339
<211> 2008
<212> DNA
<213> Homo sapiens

<400> 339
agaaggtttc atttccgggt ggcgcgggcg ccattttgtg aggagcgata taaacgggcg       60

cagaggccgg ctgcccgccc agttgttact caggtgcgct agcctgcgga gcccgtccgt      120

gctgttctgc ggcaaggcct ttcccagtgt ccccacgcgg aaggcaactg cctgagaggc      180

gcggcgtcgc accgcccaga gctgaggaag ccggcgccag ttcgcggggc tccgggccgc      240

cactcagagc tatgagctac ggccgccccc ctcccgatgt ggagggtatg acctccctca      300

aggtggacaa cctgacctac cgcacctcgc ccgacacgct gaggcgcgtc ttcgagaagt      360

acgggcgcgt cggcgacgtg tacatcccgc gggaccgcta caccaaggag tcccgcggct      420

tcgccttcgt tcgctttcac gacaagcgcg acgctgagga cgctatggat gccatggacg      480

gggccgtgct ggacggccgc gagctgcggg tgcaaatggc gcgctacggc cgccccccgg      540

actcacacca cagccgccgg ggaccgccac cccgcaggta cgggggcggt ggctacggac      600

gccggagccg cagccctagg cggcgtcgcc gcagccgatc ccggagtcgg agccgttcca      660

ggtctcgcag ccgatctcgc tacagccgct cgaagtctcg gtcccgcact cgttctcgat      720

ctcggtcgac ctccaagtcc agatccgcac gaaggtccaa gtccaagtcc tcgtcggtct      780

ccagatctcg ttcgcggtcc aggtcccggt ctcggtccag gagtcctccc ccagtgtcca      840

agagggaatc caaatccagg tcgcgatcga agagtccccc caagtctcct gaagaggaag      900

gagcggtgtc ctcttaagaa aatgatgtat cggcaagcag tgtaaacgga ggacttgggg      960

aaaaaggacc acatagtcca tcgaagaaga gtccttggaa caagcaactg gctattgaaa     1020

aggttatttt gtaacatttg tctaactttt tacttgttta agctttgcct cagttggcaa     1080

acttcatttt atgtgccatt ttgttgctgt tattcaaatt tcttgtaatt tagtgaggtg     1140

aacgacttca gatttcatta ttggatttgg atatttgagg taaaatttca ttttgttata     1200

tagtgctgac tttttttgtt tgaaattaaa cagattggta acctaatttg tggcctcctg     1260

acttttaagg aaaacgtgtg cagccattac acacagccta aagctgtcaa gagattgact     1320

cggcattgcc ttcattcctt aaaattaaaa acctacaaaa gttggtgtaa atttgtatat     1380

gttatttacc ttcagatcta aatggtaatc tgaacccaaa tttgtataaa gacttttcag     1440

gtgaaaagac ttgatttttt gaaaggattg tttatcaaac acaattctaa tctcttctct     1500

tatgtatttt tgtgcactag gcgcagttgt gtagcagttg agtaatgctg gttagctgtt     1560

aaggtggcgt gttgcagtgc agagtgcttg gctgtttcct gttttctccc gattgctcct     1620

gtgtaaagat gccttgtcgt gcagaaacaa atggctgtcc agtttattaa aatgcctgac     1680

aactgcactt ccagtcaccc gggccttgca tataaataac ggagcataca gtgagcacat     1740

ctagctgatg ataaatacac ctttttttcc ctcttccccc taaaaatggt aaatctgatc     1800

atatctacat gtatgaactt aacatggaaa atgttaagga agcaaatggt tgtaactttg     1860

taagtactta taacatggtg tatctttttg cttatgaata ttctgtatta taaccattgt     1920

ttctgtagtt taattaaaac attttcttgg tgttagcttt tctcagaaaa aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                        2008


<210> 340
<211> 221
<212> PRT
<213> Homo sapiens

<400> 340
Met Ser Tyr Gly Arg Pro Pro Pro Asp Val Glu Gly Met Thr Ser Leu 
1               5                   10                  15      


Lys Val Asp Asn Leu Thr Tyr Arg Thr Ser Pro Asp Thr Leu Arg Arg 
            20                  25                  30          


Val Phe Glu Lys Tyr Gly Arg Val Gly Asp Val Tyr Ile Pro Arg Asp 
        35                  40                  45              


Arg Tyr Thr Lys Glu Ser Arg Gly Phe Ala Phe Val Arg Phe His Asp 
    50                  55                  60                  


Lys Arg Asp Ala Glu Asp Ala Met Asp Ala Met Asp Gly Ala Val Leu 
65                  70                  75                  80  


Asp Gly Arg Glu Leu Arg Val Gln Met Ala Arg Tyr Gly Arg Pro Pro 
                85                  90                  95      


Asp Ser His His Ser Arg Arg Gly Pro Pro Pro Arg Arg Tyr Gly Gly 
            100                 105                 110         


Gly Gly Tyr Gly Arg Arg Ser Arg Ser Pro Arg Arg Arg Arg Arg Ser 
        115                 120                 125             


Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Tyr 
    130                 135                 140                 


Ser Arg Ser Lys Ser Arg Ser Arg Thr Arg Ser Arg Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Lys Ser Arg Ser Ala Arg Arg Ser Lys Ser Lys Ser Ser Ser Val 
                165                 170                 175     


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Pro 
            180                 185                 190         


Pro Pro Val Ser Lys Arg Glu Ser Lys Ser Arg Ser Arg Ser Lys Ser 
        195                 200                 205             


Pro Pro Lys Ser Pro Glu Glu Glu Gly Ala Val Ser Ser 
    210                 215                 220     


<210> 341
<211> 2304
<212> DNA
<213> Homo sapiens

<400> 341
acaagggacc ttatttaggt tgcgcaggcg cccgctggcc atttcgtctt agccacgcag       60

aagtcgcgtg tctaggtgag tcgcggtggg tcctcgcttg cagttcagcg accacgtttg      120

tttcgacgcc ggaccgcgta agagacgatg atgttgggca cggaaggtgg agagggattc      180

gtggtgaagg tccggggctt gccctggtct tgctcggccg atgaagtgca gaggtttttt      240

tctgactgca aaattcaaaa tggggctcaa ggtattcgtt tcatctacac cagagaaggc      300

agaccaagtg gcgaggcttt tgttgaactt gaatcagaag atgaagtcaa attggccctg      360

aaaaaagaca gagaaactat gggacacaga tatgttgaag tattcaagtc aaacaacgtt      420

gaaatggatt gggtgttgaa gcatactggt ccaaatagtc ctgacacggc caatgatggc      480

tttgtacggc ttagaggact tccctttgga tgtagcaagg aagaaattgt tcagttcttc      540

tcagggttgg aaatcgtgcc aaatgggata acattgccgg tggacttcca ggggaggagt      600

acgggggagg ccttcgtgca gtttgcttca caggaaatag ctgaaaaggc tctaaagaaa      660

cacaaggaaa gaatagggca caggtatatt gaaatcttta agagcagtag agctgaagtt      720

agaactcatt atgatccacc acgaaagctt atggccatgc agcggccagg tccttatgac      780

agacctgggg ctggtagagg gtataacagc attggcagag gagctggctt tgagaggatg      840

aggcgtggtg cttatggtgg aggctatgga ggctatgatg attacaatgg ctataatgat      900

ggctatggat ttgggtcaga tagatttgga agagacctca attactgttt ttcaggaatg      960

tctgatcaca gatacgggga tggtggctct actttccaga gcacaacagg acactgtgta     1020

cacatgcggg gattacctta cagagctact gagaatgaca tttataattt tttttcaccg     1080

ctcaaccctg tgagagtaca cattgaaatt ggtcctgatg gcagagtaac tggtgaagca     1140

gatgtcgagt tcgcaactca tgaagatgct gtggcagcta tgtcaaaaga caaagcaaat     1200

atgcaacaca gatatgtaga actcttcttg aattctacag caggagcaag cggtggtgct     1260

tacgaacaca gatatgtaga actcttcttg aattctacag caggagcaag cggtggtgct     1320

tatggtagcc aaatgatggg aggcatgggc ttgtcaaacc agtccagcta cgggggccca     1380

gccagccagc agctgagtgg gggttacgga ggcggctacg gtggccagag cagcatgagt     1440

ggatacgacc aagttttaca ggaaaactcc agtgattttc aatcaaacat tgcataggta     1500

accaaggagc agtgaacagc agctactaca gtagtggaag ccgtgcatct atgggcgtga     1560

acggaatggg agggttgtct agcatgtcca gtatgagtgg tggatgggga atgtaattga     1620

tcgatcctga tcactgactc ttggtcaacc tttttttttt tttttttttt ttctttaaga     1680

aaacttcagt ttaacagttt ctgcaataca agcttgtgat ttatgcttac tctaagtgga     1740

aatcaggatt gttatgaaga cttaaggccc agtatttttg aatacaatac tcatctagga     1800

tgtaacagtg aagctgagta aactataact gttaaactta agttccagct tttctcaagt     1860

tagttatagg atgtacttaa gcagtaagcg tatttaggta aaagcagttg aattatgtta     1920

aatgttgccc tttgccacgt taaattgaac actgttttgg atgcatgttg aaagacatgc     1980

ttttattttt ttgtaaaaca atataggagc tgtgtctact attaaaagtg aaacattttg     2040

gcatgtttgt taattctagt ttcatttaat aacctgtaag gcacgtaagt ttaagctttt     2100

ttttttttta agttaatggg aaaaatttga gacgcaatac caatacttag gattttggtc     2160

ttggtgtttg tatgaaattc tgaggccttg atttaaatct ttcattgtat tgtgatttcc     2220

ttttaggtat attgcgctaa gtgaaacttg tcaaataaat cctcctttta aaaactgcaa     2280

aaaaaaaaaa aaaaaaaaaa aaaa                                            2304


<210> 342
<211> 449
<212> PRT
<213> Homo sapiens

<400> 342
Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
    210                 215                 220                 


Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                245                 250                 255     


Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
        355                 360                 365             


Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
    370                 375                 380                 


Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
385                 390                 395                 400 


Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                405                 410                 415     


Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
            420                 425                 430         


Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
        435                 440                 445             


Ala 
    


<210> 343
<211> 7219
<212> DNA
<213> Homo sapiens

<400> 343
ggaccccggc aagcccgcgc acttggcagg agctgtagct accgccgtcc gcgcctccaa       60

ggtttcacgg cttcctcagc agagactcgg gctcgtccgc catgtccgcc gcagacgagg      120

ttgacgggct gggcgtggcc cggccgcact atggctctgt cctggataat gaaagactta      180

ctgcagagga gatggatgaa aggagacgtc agaacgtggc ttatgagtac ctttgtcatt      240

tggaagaagc gaagaggtgg atggaagcat gcctagggga agatctgcct cccaccacag      300

aactggagga ggggcttagg aatggggtct accttgccaa actggggaac ttcttctctc      360

ccaaagtagt gtccctgaaa aaaatctatg atcgagaaca gaccagatac aaggcgactg      420

gcctccactt tagacacact gataatgtga ttcagtggtt gaatgccatg gatgagattg      480

gattgcctaa gattttttac ccagaaacta cagatatcta tgatcgaaag aacatgccaa      540

gatgtatcta ctgtatccat gcactcagtt tgtacctgtt caagctaggc ctggcccctc      600

agattcaaga cctatatgga aaggttgact tcacagaaga agaaatcaac aacatgaaga      660

ctgagttgga gaagtatggc atccagatgc ctgcctttag caagattggg ggcatcttgg      720

ctaatgaact gtcagtggat gaagccgcat tacatgctgc tgttattgct attaatgaag      780

ctattgaccg tagaattcca gccgacacat ttgcagcttt gaaaaatccg aatgccatgc      840

ttgtaaatct tgaagagccc ttggcatcca cttaccagga tatactttac caggctaagc      900

aggacaaaat gacaaatgct aaaaacagga cagaaaactc agagagagaa agagatgttt      960

atgaggagct gctcacgcaa gctgaaattc aaggcaatat aaacaaagtc aatacatttt     1020

ctgcattagc aaatatcgac ctggctttag aacaaggaga tgcactggcc ttgttcaggg     1080

ctctgcagtc accagccctg gggcttcgag gactgcagca acagaatagc gactggtact     1140

tgaagcagct cctgagtgat aaacagcaga agagacagag tggtcagact gaccccctgc     1200

agaaggagga gctgcagtct ggagtggatg ctgcaaacag tgctgcccag caatatcaga     1260

gaagattggc agcagtagca ctgattaatg ctgcaatcca gaagggtgtt gctgagaaga     1320

ctgttttgga actgatgaat cccgaagccc agctgcccca ggtgtatcca tttgccgccg     1380

atctctatca gaaggagctg gctaccctgc agcgacaaag tcctgaacat aatctcaccc     1440

acccagagct ctctgtcgca gtggagatgt tgtcatcggt ggccctgatc aacagggcat     1500

tggaatcagg agatgtgaat acagtgtgga agcaattgag cagttcagtt actggtctta     1560

ccaatattga ggaagaaaac tgtcagaggt atctcgatga gttgatgaaa ctgaaggctc     1620

aggcacatgc agagaataat gaattcatta catggaatga tatccaagct tgcgtggacc     1680

atgtgaacct ggtggtgcaa gaggaacatg agaggatttt agccattggt ttaattaatg     1740

aagccctgga tgaaggtgat gcccaaaaga ctctgcaggc cctacagatt cctgcagcta     1800

aacttgaggg agtccttgca gaagtggccc agcattacca agacacgctg attagagcga     1860

agagagagaa agcccaggaa atccaggatg agtcagctgt gttatggttg gatgaaattc     1920

aaggtggaat ctggcagtcc aacaaagaca cccaagaagc acagaagttt gccttaggaa     1980

tctttgccat taatgaggca gtagaaagtg gtgatgttgg caaaacactg agtgcccttc     2040

gctcccctga tgttggcttg tatggagtca tccctgagtg tggtgaaact taccacagtg     2100

atcttgctga agccaagaag aaaaaactgg cagtaggaga taataacagc aagtgggtga     2160

agcactgggt aaaaggtgga tattattatt accacaatct ggagacccag gaaggaggat     2220

gggatgaacc tccaaatttt gtgcaaaatt ctatgcagct ttctcgggag gagatccaga     2280

gttctatctc tggggtgact gccgcatata accgagaaca gctgtggctg gccaatgaag     2340

gcctgatcac caggctgcag gctcgctgcc gtggatactt agttcgacag gaattccgat     2400

ccaggatgaa tttcctgaag aaacaaatcc ctgccatcac ctgcattcag tcacagtgga     2460

gaggatacaa gcagaagaag gcatatcaag atcggttagc ttacctgcgc tcccacaaag     2520

atgaagttgt aaagattcag tccctggcaa ggatgcacca agctcgaaag cgctatcgag     2580

atcgcctgca gtacttccgg gaccatataa atgacattat caaaatccag gcttttattc     2640

gggcaaacaa agctcgggat gactacaaga ctctcatcaa tgctgaggat cctcctatgg     2700

ttgtggtccg aaaatttgtc cacctgctgg accaaagtga ccaggatttt caggaggagc     2760

ttgaccttat gaagatgcgg gaagaggtta tcaccctcat tcgttctaac cagcagctgg     2820

agaatgacct caatctcatg gatatcaaaa ttggactgct agtgaaaaat aagattacgt     2880

tgcaggatgt ggtttcccac agtaaaaaac ttaccaaaaa aaataaggaa cagttgtctg     2940

atatgatgat gataaataaa cagaagggag gtctcaaggc tttgagcaag gagaagagag     3000

agaagttgga agcttaccag cacctgtttt atttattgca aaccaatccc acctatctgg     3060

ccaagctcat ttttcagatg ccccagaaca agtccaccaa gttcatggac tctgtaatct     3120

tcacactcta caactacgcg tccaaccagc gagaggagta cctgctcctg cggctcttta     3180

agacagcact ccaagaggaa atcaagtcga aggtagatca gattcaagag attgtgacag     3240

gaaatcctac ggttattaaa atggttgtaa gtttcaaccg tggtgcccgt ggccagaatg     3300

ccctgagaca gatcttggcc ccagtcgtga aggaaattat ggatgacaaa tctctcaaca     3360

tcaaaactga ccctgtggat atttacaaat cttgggttaa tcagatggag tctcagacag     3420

gagaggcaag caaactgccc tatgatgtga cccctgagca ggcgctagct catgaagaag     3480

tgaagacacg gctagacagc tccatcagga acatgcgggc tgtgacagac aagtttctct     3540

cagccattgt cagctctgtg gacaaaatcc cttatgggat gcgcttcatt gccaaagtgc     3600

tgaaggactc gttgcatgag aagttccctg atgctggtga ggatgagctg ctgaagatta     3660

ttggtaactt gctttattat cgatacatga atccagccat tgttgctcct gatgcctttg     3720

acatcattga cctgtcagca ggaggccagc ttaccacaga ccaacgccga aatctgggct     3780

ccattgcaaa aatgcttcag catgctgctt ccaataagat gtttctggga gataatgccc     3840

acttaagcat cattaatgaa tatctttccc agtcctacca gaaattcaga cggtttttcc     3900

aaactgcttg tgatgtccca gagcttcagg ataaatttaa tgtggatgag tactctgatt     3960

tagtaaccct caccaaacca gtaatctaca tttccattgg tgaaatcatc aacacccaca     4020

ctctcctgtt ggatcaccag gatgccattg ctccggagca caatgatcca atccacgaac     4080

tgctggacga cctcggcgag gtgcccacca tcgagtccct gataggggaa agctctggca     4140

atttaaatga cccaaataag gaggcactgg ctaagacgga agtgtctctc accctgacca     4200

acaagttcga cgtgcctgga gatgagaatg cagaaatgga tgctcgaacc atcttactga     4260

atacaaaacg tttaattgtg gatgtcatcc ggttccagcc aggagagacc ttgactgaaa     4320

tcctagaaac accagccacc agtgaacagg aagcagaaca tcagagagcc atgcagagac     4380

gtgctatccg tgatgccaaa acacctgaca agatgaaaaa gtcaaaatct gtaaaggaag     4440

acagcaacct cactcttcaa gagaagaaag agaagatcca gacaggttta aagaagctaa     4500

cagagcttgg aaccgtggac ccaaagaaca aataccagga actgatcaac gacattgcca     4560

gggatattcg gaatcagcgg aggtaccgac agaggagaaa ggccgaacta gtgaaactgc     4620

aacagacata cgctgctctg aactctaagg ccacctttta tggggagcag gtggattact     4680

ataaaagcta tatcaaaacc tgcttggata acttagccag caagggcaaa gtctccaaaa     4740

agcctaggga aatgaaagga aagaaaagca aaaagatttc tctgaaatat acagcagcaa     4800

gactacatga aaaaggagtt cttctggaaa ttgaggacct gcaagtgaat cagtttaaaa     4860

atgttatatt tgaaatcagt ccaacagaag aagttggaga cttcgaagtg aaagccaaat     4920

tcatgggagt tcaaatggag acttttatgt tacattatca ggacctgctg cagctacagt     4980

atgaaggagt tgcagtcatg aaattatttg atagagctaa agtaaatgtc aacctcctga     5040

tcttccttct caacaaaaag ttctacggga agtaattgat cgtttgctgc cagcccagaa     5100

ggatgaagga aagaagcacc tcacagctcc tttctaggtc cttctttcct cattggaagc     5160

aaagacctag ccaacaacag cacctcaatc tgatacactc ccgatgccac atttttaact     5220

cctctcgctc tgatgggaca tttgttaccc ttttttcata gtgaaattgt gtttcaggct     5280

tagtctgacc tttctggttt cttcattttc ttccattact taggaaagag tggaaactcc     5340

actaaaattt ctctgtgttg ttacagtctt agaggttgca gtactatatt gtaagctttg     5400

gtgtttgttt aattagcaat agggatggta ggattcaaat gtgtgtcatt tagaagtgga     5460

agctattagc accaatgaca taaatacata caagacacac aactaaaatg tcatgttatt     5520

aacagttatt aggttgtcat ttaaaaataa agttccttta tatttctgtc ccatcaggaa     5580

aactgaagga tatggggaat cattggttat cttccattgt gtttttcttt atggacagga     5640

gctaatggaa gtgacagtca tgttcaaagg aagcatttct agaaaaaagg agataatgtt     5700

tttaaatttc attatcaaac ttgggcaatt ctgtttgtgt aactccccga ctagtggatg     5760

ggagagtccc attgctaaaa ttcagctact cagataaatt cagaatgggt caaggcacct     5820

gcctgttttt gttggtgcac agagattgac ttgattcaga gagacaattc actccatccc     5880

tatggcagag gaatgggtta gccctaatgt agaatgtcat tgtttttaaa actgttttat     5940

atcttaagag tgccttatta aagtatagat gtatgtctta aaatgtgggt gataggaatt     6000

ttaaagattt atataatgca tcaaaagcct tagaataaga aaagcttttt ttaaattgct     6060

ttatctgtat atctgaactc ttgaaactta tagctaaaac actaggattt atctgcagtg     6120

ttcagggaga taattctgcc tttaattgtc taaaacaaaa acaaaaccag ccaacctatg     6180

ttacacgtga gattaaaacc aattttttcc ccattttttc tccttttttc tcttgctgcc     6240

cacattgtgc ctttatttta tgagccccag ttttctgggc ttagtttaaa aaaaaaatca     6300

agtctaaaca ttgcatttag aaagcttttg ttcttggata aaaagtcata cactttaaaa     6360

aaaaaaaaaa ctttttccag gaaaatatat tgaaatcatg ctgctgagcc tctattttct     6420

ttctttgatg ttttgattca gtattctttt atcataaatt tttagcattt aaaaattcac     6480

tgatgtacat taagccaata aactgcttta atgaataaca aactatgtag tgtgtcccta     6540

ttataaatgc attggagaag tatttttatg agactcttta ctcaggtgca tggttacagc     6600

ccacagggag gcatggagtg ccatggaagg attcgccact acccagacct tgttttttgt     6660

tgtattttgg aagacaggtt ttttaaagaa acattttcct cagattaaaa gatgatgcta     6720

ttacaactag cattgcctca aaaactggga ccaaccaaag tgtgtcaacc ctgtttcctt     6780

aaaagaggct atgaatccca aaggccacat ccaagacagg caataatgag cagagtttac     6840

agctccttta ataaaatgtg tcagtaattt taaggtttat agttccctca acacaattgc     6900

taatgcagaa tagtgtaaaa tgcgcttcaa gaatgttgat gatgatgata tagaattgtg     6960

gctttagtag cacagaggat gccccaacaa actcatggcg ttgaaaccac acagttctca     7020

ttactgttat ttattagctg tagcattctc tgtctcctct ctctcctcct ttgaccttct     7080

cctcgaccag ccatcatgac atttaccatg aatttacttc ctcccaagag tttggactgc     7140

ccgtcagatt gttgctgcac atagttgcct ttgtatctct gtatgaaata aaaggtcatt     7200

tgttcatgtt aaaaaaaaa                                                  7219


<210> 344
<211> 1657
<212> PRT
<213> Homo sapiens

<400> 344
Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His 
1               5                   10                  15      


Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp 
            20                  25                  30          


Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu 
        35                  40                  45              


Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys 
65                  70                  75                  80  


Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr 
                85                  90                  95      


Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His 
            100                 105                 110         


Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu 
        115                 120                 125             


Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn 
    130                 135                 140                 


Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe 
145                 150                 155                 160 


Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp 
                165                 170                 175     


Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr 
            180                 185                 190         


Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn 
        195                 200                 205             


Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile 
    210                 215                 220                 


Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu 
225                 230                 235                 240 


Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser 
                245                 250                 255     


Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn 
            260                 265                 270         


Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu 
        275                 280                 285             


Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn 
    290                 295                 300                 


Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp 
305                 310                 315                 320 


Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg 
                325                 330                 335     


Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser 
            340                 345                 350         


Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys 
        355                 360                 365             


Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln 
    370                 375                 380                 


Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln 
385                 390                 395                 400 


Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala 
                405                 410                 415     


Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu 
            420                 425                 430         


Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro 
        435                 440                 445             


Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn 
    450                 455                 460                 


Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser 
465                 470                 475                 480 


Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg 
                485                 490                 495     


Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn 
            500                 505                 510         


Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val 
        515                 520                 525             


Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu 
    530                 535                 540                 


Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala 
545                 550                 555                 560 


Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala 
                565                 570                 575     


Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln 
            580                 585                 590         


Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly 
        595                 600                 605             


Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala 
    610                 615                 620                 


Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly 
625                 630                 635                 640 


Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val 
                645                 650                 655     


Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys 
            660                 665                 670         


Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His 
        675                 680                 685             


Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu 
    690                 695                 700                 


Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu 
705                 710                 715                 720 


Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr 
                725                 730                 735     


Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu 
            740                 745                 750         


Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg 
        755                 760                 765             


Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser 
    770                 775                 780                 


Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala 
785                 790                 795                 800 


Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala 
                805                 810                 815     


Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe 
            820                 825                 830         


Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala 
        835                 840                 845             


Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro 
    850                 855                 860                 


Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp 
865                 870                 875                 880 


Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val 
                885                 890                 895     


Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu 
            900                 905                 910         


Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln 
        915                 920                 925             


Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln 
    930                 935                 940                 


Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala 
945                 950                 955                 960 


Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe 
                965                 970                 975     


Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln 
            980                 985                 990         


Met Pro Gln Asn Lys Ser Thr Lys  Phe Met Asp Ser Val  Ile Phe Thr 
        995                 1000                 1005             


Leu Tyr  Asn Tyr Ala Ser Asn  Gln Arg Glu Glu Tyr  Leu Leu Leu 
    1010                 1015                 1020             


Arg Leu  Phe Lys Thr Ala Leu  Gln Glu Glu Ile Lys  Ser Lys Val 
    1025                 1030                 1035             


Asp Gln  Ile Gln Glu Ile Val  Thr Gly Asn Pro Thr  Val Ile Lys 
    1040                 1045                 1050             


Met Val  Val Ser Phe Asn Arg  Gly Ala Arg Gly Gln  Asn Ala Leu 
    1055                 1060                 1065             


Arg Gln  Ile Leu Ala Pro Val  Val Lys Glu Ile Met  Asp Asp Lys 
    1070                 1075                 1080             


Ser Leu  Asn Ile Lys Thr Asp  Pro Val Asp Ile Tyr  Lys Ser Trp 
    1085                 1090                 1095             


Val Asn  Gln Met Glu Ser Gln  Thr Gly Glu Ala Ser  Lys Leu Pro 
    1100                 1105                 1110             


Tyr Asp  Val Thr Pro Glu Gln  Ala Leu Ala His Glu  Glu Val Lys 
    1115                 1120                 1125             


Thr Arg  Leu Asp Ser Ser Ile  Arg Asn Met Arg Ala  Val Thr Asp 
    1130                 1135                 1140             


Lys Phe  Leu Ser Ala Ile Val  Ser Ser Val Asp Lys  Ile Pro Tyr 
    1145                 1150                 1155             


Gly Met  Arg Phe Ile Ala Lys  Val Leu Lys Asp Ser  Leu His Glu 
    1160                 1165                 1170             


Lys Phe  Pro Asp Ala Gly Glu  Asp Glu Leu Leu Lys  Ile Ile Gly 
    1175                 1180                 1185             


Asn Leu  Leu Tyr Tyr Arg Tyr  Met Asn Pro Ala Ile  Val Ala Pro 
    1190                 1195                 1200             


Asp Ala  Phe Asp Ile Ile Asp  Leu Ser Ala Gly Gly  Gln Leu Thr 
    1205                 1210                 1215             


Thr Asp  Gln Arg Arg Asn Leu  Gly Ser Ile Ala Lys  Met Leu Gln 
    1220                 1225                 1230             


His Ala  Ala Ser Asn Lys Met  Phe Leu Gly Asp Asn  Ala His Leu 
    1235                 1240                 1245             


Ser Ile  Ile Asn Glu Tyr Leu  Ser Gln Ser Tyr Gln  Lys Phe Arg 
    1250                 1255                 1260             


Arg Phe  Phe Gln Thr Ala Cys  Asp Val Pro Glu Leu  Gln Asp Lys 
    1265                 1270                 1275             


Phe Asn  Val Asp Glu Tyr Ser  Asp Leu Val Thr Leu  Thr Lys Pro 
    1280                 1285                 1290             


Val Ile  Tyr Ile Ser Ile Gly  Glu Ile Ile Asn Thr  His Thr Leu 
    1295                 1300                 1305             


Leu Leu  Asp His Gln Asp Ala  Ile Ala Pro Glu His  Asn Asp Pro 
    1310                 1315                 1320             


Ile His  Glu Leu Leu Asp Asp  Leu Gly Glu Val Pro  Thr Ile Glu 
    1325                 1330                 1335             


Ser Leu  Ile Gly Glu Ser Ser  Gly Asn Leu Asn Asp  Pro Asn Lys 
    1340                 1345                 1350             


Glu Ala  Leu Ala Lys Thr Glu  Val Ser Leu Thr Leu  Thr Asn Lys 
    1355                 1360                 1365             


Phe Asp  Val Pro Gly Asp Glu  Asn Ala Glu Met Asp  Ala Arg Thr 
    1370                 1375                 1380             


Ile Leu  Leu Asn Thr Lys Arg  Leu Ile Val Asp Val  Ile Arg Phe 
    1385                 1390                 1395             


Gln Pro  Gly Glu Thr Leu Thr  Glu Ile Leu Glu Thr  Pro Ala Thr 
    1400                 1405                 1410             


Ser Glu  Gln Glu Ala Glu His  Gln Arg Ala Met Gln  Arg Arg Ala 
    1415                 1420                 1425             


Ile Arg  Asp Ala Lys Thr Pro  Asp Lys Met Lys Lys  Ser Lys Ser 
    1430                 1435                 1440             


Val Lys  Glu Asp Ser Asn Leu  Thr Leu Gln Glu Lys  Lys Glu Lys 
    1445                 1450                 1455             


Ile Gln  Thr Gly Leu Lys Lys  Leu Thr Glu Leu Gly  Thr Val Asp 
    1460                 1465                 1470             


Pro Lys  Asn Lys Tyr Gln Glu  Leu Ile Asn Asp Ile  Ala Arg Asp 
    1475                 1480                 1485             


Ile Arg  Asn Gln Arg Arg Tyr  Arg Gln Arg Arg Lys  Ala Glu Leu 
    1490                 1495                 1500             


Val Lys  Leu Gln Gln Thr Tyr  Ala Ala Leu Asn Ser  Lys Ala Thr 
    1505                 1510                 1515             


Phe Tyr  Gly Glu Gln Val Asp  Tyr Tyr Lys Ser Tyr  Ile Lys Thr 
    1520                 1525                 1530             


Cys Leu  Asp Asn Leu Ala Ser  Lys Gly Lys Val Ser  Lys Lys Pro 
    1535                 1540                 1545             


Arg Glu  Met Lys Gly Lys Lys  Ser Lys Lys Ile Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Thr Ala  Ala Arg Leu His Glu  Lys Gly Val Leu Leu  Glu Ile Glu 
    1565                 1570                 1575             


Asp Leu  Gln Val Asn Gln Phe  Lys Asn Val Ile Phe  Glu Ile Ser 
    1580                 1585                 1590             


Pro Thr  Glu Glu Val Gly Asp  Phe Glu Val Lys Ala  Lys Phe Met 
    1595                 1600                 1605             


Gly Val  Gln Met Glu Thr Phe  Met Leu His Tyr Gln  Asp Leu Leu 
    1610                 1615                 1620             


Gln Leu  Gln Tyr Glu Gly Val  Ala Val Met Lys Leu  Phe Asp Arg 
    1625                 1630                 1635             


Ala Lys  Val Asn Val Asn Leu  Leu Ile Phe Leu Leu  Asn Lys Lys 
    1640                 1645                 1650             


Phe Tyr  Gly Lys 
    1655         


<210> 345
<211> 1180
<212> DNA
<213> Homo sapiens

<400> 345
ggaggggcgg ggcggacgca gagccgcgtt tagtctatcg ctgcggttgc gagcgctgta       60

gggagcctgt gctgtgccgc gcagttaggc agcagcagcc gcggagcagt agccgccgtg      120

ggagggagcc atgaagcatt acgaggtgga gattctggac gcaaagacaa gggagaagct      180

gtgtttcttg gacaaggtgg agccccacgc caccattgcg gagatcaaga acctcttcac      240

taagacccat ccgcagtggt accccgcccg ccagtccctc cgcctggacc ccaagggcaa      300

gtccctgaag gatgaggatg ttctgcagaa gctgcccgtg ggcaccacgg ccacactgta      360

cttccgggac ctgggggccc agatcagctg ggtgacggtc ttcctaacag agtacgcggg      420

gccccttttc atctacctgc tcttctactt ccgagtgccc ttcatctatg gccacaaata      480

tgactttacg tccagtcggc atacagtggt gcacctcgcc tgcatctgtc actcattcca      540

ctacatcaag cgcctgctgg agacgctctt cgtgcaccgc ttctcccatg gcactatgcc      600

tttgcgcaac atcttcaaga actgcaccta ctactggggc ttcgccgcgt ggatggccta      660

ttacatcaat caccctctct acactccccc tacctacgga gctcagcagg tgaaactggc      720

gctcgccatc tttgtgatct gccagctcgg caacttctcc atccacatgg ccctgcggga      780

cctgcggccc gctgggtcca agacgcggaa gatcccatac cccaccaaga accccttcac      840

gtggctcttc ctgctggtgt cctgccccaa ctacacctac gaggtggggt cctggatcgg      900

tttcgccatc atgacgcagt gtctcccagt ggccctgttc tccctggtgg gcttcaccca      960

gatgaccatc tgggccaagg gcaagcaccg cagctacctg aaggagttcc gggactaccc     1020

gcccctgcgc atgcccatca tccccttcct gctctgagcg ctcacccctg ctgaggctca     1080

gcccctcaac ccggtggcat tctgggggag gagtggggcc cacagctctc cagcacccgg     1140

aataaagccc gcctgcccca gtcggaaaaa aaaaaaaaaa                           1180


<210> 346
<211> 308
<212> PRT
<213> Homo sapiens

<400> 346
Met Lys His Tyr Glu Val Glu Ile Leu Asp Ala Lys Thr Arg Glu Lys 
1               5                   10                  15      


Leu Cys Phe Leu Asp Lys Val Glu Pro His Ala Thr Ile Ala Glu Ile 
            20                  25                  30          


Lys Asn Leu Phe Thr Lys Thr His Pro Gln Trp Tyr Pro Ala Arg Gln 
        35                  40                  45              


Ser Leu Arg Leu Asp Pro Lys Gly Lys Ser Leu Lys Asp Glu Asp Val 
    50                  55                  60                  


Leu Gln Lys Leu Pro Val Gly Thr Thr Ala Thr Leu Tyr Phe Arg Asp 
65                  70                  75                  80  


Leu Gly Ala Gln Ile Ser Trp Val Thr Val Phe Leu Thr Glu Tyr Ala 
                85                  90                  95      


Gly Pro Leu Phe Ile Tyr Leu Leu Phe Tyr Phe Arg Val Pro Phe Ile 
            100                 105                 110         


Tyr Gly His Lys Tyr Asp Phe Thr Ser Ser Arg His Thr Val Val His 
        115                 120                 125             


Leu Ala Cys Ile Cys His Ser Phe His Tyr Ile Lys Arg Leu Leu Glu 
    130                 135                 140                 


Thr Leu Phe Val His Arg Phe Ser His Gly Thr Met Pro Leu Arg Asn 
145                 150                 155                 160 


Ile Phe Lys Asn Cys Thr Tyr Tyr Trp Gly Phe Ala Ala Trp Met Ala 
                165                 170                 175     


Tyr Tyr Ile Asn His Pro Leu Tyr Thr Pro Pro Thr Tyr Gly Ala Gln 
            180                 185                 190         


Gln Val Lys Leu Ala Leu Ala Ile Phe Val Ile Cys Gln Leu Gly Asn 
        195                 200                 205             


Phe Ser Ile His Met Ala Leu Arg Asp Leu Arg Pro Ala Gly Ser Lys 
    210                 215                 220                 


Thr Arg Lys Ile Pro Tyr Pro Thr Lys Asn Pro Phe Thr Trp Leu Phe 
225                 230                 235                 240 


Leu Leu Val Ser Cys Pro Asn Tyr Thr Tyr Glu Val Gly Ser Trp Ile 
                245                 250                 255     


Gly Phe Ala Ile Met Thr Gln Cys Leu Pro Val Ala Leu Phe Ser Leu 
            260                 265                 270         


Val Gly Phe Thr Gln Met Thr Ile Trp Ala Lys Gly Lys His Arg Ser 
        275                 280                 285             


Tyr Leu Lys Glu Phe Arg Asp Tyr Pro Pro Leu Arg Met Pro Ile Ile 
    290                 295                 300                 


Pro Phe Leu Leu 
305             


<210> 347
<211> 3601
<212> DNA
<213> Homo sapiens

<400> 347
ttttgagggg ggcgcctcgt cccgcccctc cctcctgtcc tccctcccgt cctccccgct       60

ccgggcccca cccggctcag acggctccgg acgggaccgc gagcacaggc cgctccgcgg      120

gcgcttcgga tcctcgcggg accccaccct ctcccagcct gcccagcccg ctgcagccgc      180

cagcgcgccc cgtcggcagc tctccatctg cacgtctctc cgtgaacccc gtgagcggtg      240

tgcagccacc atgttcagct ggctgaagcg gggcggggca cggggccagc agcccgaggc      300

catccgcacg gtgacctcgg ccctcaagga gctgtaccgc acgaagctgc tgccgctgga      360

ggagcactac cgctttgggg ccttccactc gccggccctg gaggacgcag acttcgacgg      420

caagcccatg gtgctggtgg ccggccagta cagcacgggc aagaccagct tcatccagta      480

cctgctggag caggaggtgc ccggctcccg cgtggggcct gagcccacca ccgactgctt      540

tgtggccgtc atgcacgggg acactgaggg caccgtgccc ggcaacgccc tcgtcgtgga      600

cccggacaag cccttccgca aactcaaccc tttcggaaac accttcctca acaggttcat      660

gtgtgcccag ctccctaatc aggtcctgga gagcatcagc atcatcgaca ccccgggtat      720

cctgtcgggt gccaagcaga gagtgagccg cggctacgac ttcccggccg tgctgcgctg      780

gttcgcggag cgcgtggacc tcatcatcct gctctttgat gcgcacaagc tggagatctc      840

ggacgagttc tcagaggcca tcggcgcgtt gcggggccat gaggacaaga tccgcgtggt      900

gctcaacaag gccgacatgg tggagacgca gcagctgatg cgcgtctacg gcgcgctcat      960

gtgggcgctg ggcaaggtgg tgggcacgcc cgaggtgctg cgcgtctaca tcggctcctt     1020

ctggtcccag cccctcctcg tgcccgacaa ccggcgcctc ttcgagctgg aggagcagga     1080

cctcttccgc gacatccagg gcctgccccg gcacgcagcc ttgcgcaagc tcaacgacct     1140

ggtgaagagg gcccggctgg tgcgagttca cgcttacatc atcagctacc tgaagaagga     1200

gatgccctct gtgtttggga aggagaacaa gaagaagcag ctgatcctca aactgcccgt     1260

catctttgcg aagattcagc tggaacatca catctcccct ggggactttc ctgattgcca     1320

gaaaatgcag gagctgctga tggcgcacga cttcaccaag tttcactcgc tgaagccgaa     1380

gctgctagag gcactggacg agatgctgac gcacgacatc gccaagctca tgcccctgct     1440

gcggcaggag gagctggaga gcaccgaggt gggcgtgcag gggggcgctt ttgagggcac     1500

ccacatgggc ccgtttgtgg agcggggacc tgacgaggcc atggaggacg gcgaggaggg     1560

ctcggacgac gaggccgagt gggtggtgac caaggacaag tccaaatacg acgagatctt     1620

ctacaacctg gcgcctgccg acggcaagct gagcggctcc aaggccaaga cctggatggt     1680

ggggaccaag ctccccaact cagtgctggg gcgcatctgg aagctcagcg atgtggaccg     1740

cgacggcatg ctggatgatg aggagttcgc gctggccagc cacctcatcg aggccaagct     1800

ggaaggccac gggctgcccg ccaacctgcc ccgtcgcctg gtgccaccct ccaagcgacg     1860

ccacaagggc tccgccgagt gagccggccc ccctcccatg gccctgctgt ggctccccag     1920

ctccagtcgg ctgcacgcac acccctgctc cggctcacac acgccctgcc tgccctccct     1980

gcccagctgt aaggaccggg ggtctccctc ctcactaccg ccagacaccc cggtggaagc     2040

atttagaggg gaccacggga gggacaaggc ttctctgtcc gcccttcaca cctccagcct     2100

cacgttcact taggcacatc acacacacac tggcacacgc aggcatccat ccatccgtca     2160

ttcattcaaa tatttattga gcacctacta tgtgcccagc cctgttctag gcactgggca     2220

ttaccataga gaacaaaata gacaaataca tctgccctca tggaaggtga cgttcccagg     2280

agagggcacc tacacagtca cgcaaacaca cactaattcc tggcagggcc cccagcccct     2340

cccctggctg agcagccctg tggctgaaat gactagcaga taaacagacc cccttctgct     2400

ccgcttcctc ctgcccagcc aggcaacacc ctcaaccggc tccatcacat cctcaggtct     2460

cgggaccatg gggggctcag aggggagaca cacctactgc ttcctcagat gggcccctcc     2520

gcagcccctt cccttgctcg gggaaagccc ccaattctgc ccacacccat ttatttcctt     2580

ccttccttcc ttcttttctt tccttccttc cttctttttt gtttttgccc ccaattctgc     2640

ccatacccat ttctttcttt ccttccttcc ttcttttttg tttttgcccc cagttctgtc     2700

cacacccctt ccctttcctg tcctgtcctt tctttctttt ttgatagaat cttgctctgt     2760

cgcccaggct ggagtgcagt ggtgagatct cagctcactg caacctccac ctcctgggtt     2820

gaagtgattc tcgtgcctca gcctcctgag tagctgggac tgcaggcacg cgccaccacg     2880

cccagctaat ttttgtattt gagtagagac ggggtttcac catgttggcc aggctggtct     2940

cgaactccgc atctcaggtg atctgctcgc cttggcctcc caaagtgatg ggattacagg     3000

catgagccac cgtgcccggc ttcacaccca tttctttaaa aaggatcccg tagcaggcag     3060

aaaagcccct tccatcctgc tcctctgata ctgtgccccc ttggagatat ttccgtcctc     3120

cacccacgtg tctgtggctg gaactgccca gcctgctcct ggccccctgg aagcctcccc     3180

acagctggta atctggactt aaggattgct gggccaccgc ctctctgcct accaccattc     3240

catatttaag tggagcccct acgtagaaag gccccggggc tttattttag tctccttttc     3300

agggatgtcg tgggcggggg agggggttct tggtgctaca gccctctccc cacccctaaa     3360

gggacgccga cgctgtttgc tgccttcacc acatattagt gcttgaccct ggcaggggac     3420

cccatggaaa agatggggaa gagcaaaata catggagacg acgcaccctc caggatgctc     3480

gctgggattc ccacgcccac cactgtcccc caccccatgg ctgggagggg cctctgaacg     3540

gaacagtgtc cccacagagc gaataaagcc aaggcttctt cccaaaaaaa aaaaaaaaaa     3600

a                                                                     3601


<210> 348
<211> 543
<212> PRT
<213> Homo sapiens

<400> 348
Met Phe Ser Trp Leu Lys Arg Gly Gly Ala Arg Gly Gln Gln Pro Glu 
1               5                   10                  15      


Ala Ile Arg Thr Val Thr Ser Ala Leu Lys Glu Leu Tyr Arg Thr Lys 
            20                  25                  30          


Leu Leu Pro Leu Glu Glu His Tyr Arg Phe Gly Ala Phe His Ser Pro 
        35                  40                  45              


Ala Leu Glu Asp Ala Asp Phe Asp Gly Lys Pro Met Val Leu Val Ala 
    50                  55                  60                  


Gly Gln Tyr Ser Thr Gly Lys Thr Ser Phe Ile Gln Tyr Leu Leu Glu 
65                  70                  75                  80  


Gln Glu Val Pro Gly Ser Arg Val Gly Pro Glu Pro Thr Thr Asp Cys 
                85                  90                  95      


Phe Val Ala Val Met His Gly Asp Thr Glu Gly Thr Val Pro Gly Asn 
            100                 105                 110         


Ala Leu Val Val Asp Pro Asp Lys Pro Phe Arg Lys Leu Asn Pro Phe 
        115                 120                 125             


Gly Asn Thr Phe Leu Asn Arg Phe Met Cys Ala Gln Leu Pro Asn Gln 
    130                 135                 140                 


Val Leu Glu Ser Ile Ser Ile Ile Asp Thr Pro Gly Ile Leu Ser Gly 
145                 150                 155                 160 


Ala Lys Gln Arg Val Ser Arg Gly Tyr Asp Phe Pro Ala Val Leu Arg 
                165                 170                 175     


Trp Phe Ala Glu Arg Val Asp Leu Ile Ile Leu Leu Phe Asp Ala His 
            180                 185                 190         


Lys Leu Glu Ile Ser Asp Glu Phe Ser Glu Ala Ile Gly Ala Leu Arg 
        195                 200                 205             


Gly His Glu Asp Lys Ile Arg Val Val Leu Asn Lys Ala Asp Met Val 
    210                 215                 220                 


Glu Thr Gln Gln Leu Met Arg Val Tyr Gly Ala Leu Met Trp Ala Leu 
225                 230                 235                 240 


Gly Lys Val Val Gly Thr Pro Glu Val Leu Arg Val Tyr Ile Gly Ser 
                245                 250                 255     


Phe Trp Ser Gln Pro Leu Leu Val Pro Asp Asn Arg Arg Leu Phe Glu 
            260                 265                 270         


Leu Glu Glu Gln Asp Leu Phe Arg Asp Ile Gln Gly Leu Pro Arg His 
        275                 280                 285             


Ala Ala Leu Arg Lys Leu Asn Asp Leu Val Lys Arg Ala Arg Leu Val 
    290                 295                 300                 


Arg Val His Ala Tyr Ile Ile Ser Tyr Leu Lys Lys Glu Met Pro Ser 
305                 310                 315                 320 


Val Phe Gly Lys Glu Asn Lys Lys Lys Gln Leu Ile Leu Lys Leu Pro 
                325                 330                 335     


Val Ile Phe Ala Lys Ile Gln Leu Glu His His Ile Ser Pro Gly Asp 
            340                 345                 350         


Phe Pro Asp Cys Gln Lys Met Gln Glu Leu Leu Met Ala His Asp Phe 
        355                 360                 365             


Thr Lys Phe His Ser Leu Lys Pro Lys Leu Leu Glu Ala Leu Asp Glu 
    370                 375                 380                 


Met Leu Thr His Asp Ile Ala Lys Leu Met Pro Leu Leu Arg Gln Glu 
385                 390                 395                 400 


Glu Leu Glu Ser Thr Glu Val Gly Val Gln Gly Gly Ala Phe Glu Gly 
                405                 410                 415     


Thr His Met Gly Pro Phe Val Glu Arg Gly Pro Asp Glu Ala Met Glu 
            420                 425                 430         


Asp Gly Glu Glu Gly Ser Asp Asp Glu Ala Glu Trp Val Val Thr Lys 
        435                 440                 445             


Asp Lys Ser Lys Tyr Asp Glu Ile Phe Tyr Asn Leu Ala Pro Ala Asp 
    450                 455                 460                 


Gly Lys Leu Ser Gly Ser Lys Ala Lys Thr Trp Met Val Gly Thr Lys 
465                 470                 475                 480 


Leu Pro Asn Ser Val Leu Gly Arg Ile Trp Lys Leu Ser Asp Val Asp 
                485                 490                 495     


Arg Asp Gly Met Leu Asp Asp Glu Glu Phe Ala Leu Ala Ser His Leu 
            500                 505                 510         


Ile Glu Ala Lys Leu Glu Gly His Gly Leu Pro Ala Asn Leu Pro Arg 
        515                 520                 525             


Arg Leu Val Pro Pro Ser Lys Arg Arg His Lys Gly Ser Ala Glu 
    530                 535                 540             


<210> 349
<211> 2129
<212> DNA
<213> Homo sapiens

<400> 349
tttccgcatt gaaggggctg ctccgaatgg agggggaggg gaggtgttta ggagaaagta       60

ggggctgtgg gtgtcgggag ccggctgacg ggtggacaag ggggggttag cagctgggct      120

gcgaccgtta gggaggggct caaggtgtgc atgtgtgagg gaagagagag agagagaagg      180

gcgcctcaga ggtgactttc agcctgcgag ccttcttccc ggggcgccat aaacgccccc      240

aatttcccag ctgctaaagg aagaggaaga tcttagcaaa gcaatgtctc aagatggtgc      300

ttctcagttc caagaagtca ttcggcaaga gctagaatta tctgtgaaga aggaactaga      360

aaaaatactc accacagcat catcacatga atttgagcac accaaaaaag acctggatgg      420

atttcggaag ctatttcata gatttttgca agaaaagggg ccttctgtgg attggggaaa      480

aatccagaga ccccctgaag attcgattca accctatgaa aagataaagg ccaggggctt      540

gcctgataat atatcttccg tgttgaacaa actagtggtg gtgaaactca atggtggttt      600

gggaaccagc atgggctgca aaggccctaa aagtctgatt ggtgtgagga atgagaatac      660

ctttctggat ctgactgttc agcaaattga acatttgaat aaaacctaca atacagatgt      720

tcctcttgtt ttaatgaact cttttaacac ggatgaagat accaaaaaaa tactacagaa      780

gtacaatcat tgtcgtgtga aaatctacac tttcaatcaa agcaggtacc cgaggattaa      840

taaagaatct ttacttcctg tagcaaagga cgtgtcttac tcaggggaaa atacagaagc      900

ttggtaccct ccaggtcatg gtgatattta cgccagtttc tacaactctg gattgcttga      960

tacctttata ggagaaggca aagagtatat ttttgtgtct aacatagata atctgggtgc     1020

cacagtggat ctgtatattc ttaatcatct aatgaaccca cccaatggaa aacgctgtga     1080

atttgtcatg gaagtcacaa ataaaacacg tgcagatgta aagggcggga cactcactca     1140

atatgaaggc aaactgagac tggtggaaat tgctcaagtg ccaaaagcac atgtagacga     1200

gttcaagtct gtatcaaagt tcaaaatatt taatacaaac aacctatgga tttctcttgc     1260

agcagttaaa agactgcagg agcaaaatgc cattgacatg gaaatcattg tgaatgcaaa     1320

gactttggat ggaggcctga atgtcattca attagaaact gcagtagggg ctgccatcaa     1380

aagttttgag aattctctag gtattaatgt gccaaggagc cgttttctgc ctgtcaaaac     1440

cacatcagat ctcttgctgg tgatgtcaaa cctctatagt cttaatgcag gatctctgac     1500

aatgagtgaa aagcgggaat ttcctacagt gcccttggtt aaattaggca gttcttttac     1560

gaaggttcaa gattatctaa gaagatttga aagtatacca gatatgcttg aattggatca     1620

cctcacagtt tcaggagatg tgacatttgg aaaaaatgtt tcattaaagg gaacggttat     1680

catcattgca aatcatggtg acagaattga tatcccacct ggagcagtat tagagaacaa     1740

gattgtgtct ggaaaccttc gcatcttgga ccactgaaat gaaaaatact gtggacactt     1800

aaataatggg ctagtttctt acaatgaaat gttctctagg attctaaaat aggcaggtac     1860

tttactatgt tactgtaccc tgcagtgttg atttttaaaa tagagttttc tgcagtatgc     1920

ttttagtcta agaaaagcac agatggagca atactttcct tctttgaaga gaatcccaaa     1980

agttagttca tcttaaagtg caatattgtt taatcttaaa actgggcaac tttggaagaa     2040

cttttaacag aagcctcaat gatgatcact ttgaattgct tgtgatttca aaaataaagc     2100

agtgaagcaa taaaaaaaaa aaaaaaaaa                                       2129


<210> 350
<211> 497
<212> PRT
<213> Homo sapiens

<400> 350
Met Ser Gln Asp Gly Ala Ser Gln Phe Gln Glu Val Ile Arg Gln Glu 
1               5                   10                  15      


Leu Glu Leu Ser Val Lys Lys Glu Leu Glu Lys Ile Leu Thr Thr Ala 
            20                  25                  30          


Ser Ser His Glu Phe Glu His Thr Lys Lys Asp Leu Asp Gly Phe Arg 
        35                  40                  45              


Lys Leu Phe His Arg Phe Leu Gln Glu Lys Gly Pro Ser Val Asp Trp 
    50                  55                  60                  


Gly Lys Ile Gln Arg Pro Pro Glu Asp Ser Ile Gln Pro Tyr Glu Lys 
65                  70                  75                  80  


Ile Lys Ala Arg Gly Leu Pro Asp Asn Ile Ser Ser Val Leu Asn Lys 
                85                  90                  95      


Leu Val Val Val Lys Leu Asn Gly Gly Leu Gly Thr Ser Met Gly Cys 
            100                 105                 110         


Lys Gly Pro Lys Ser Leu Ile Gly Val Arg Asn Glu Asn Thr Phe Leu 
        115                 120                 125             


Asp Leu Thr Val Gln Gln Ile Glu His Leu Asn Lys Thr Tyr Asn Thr 
    130                 135                 140                 


Asp Val Pro Leu Val Leu Met Asn Ser Phe Asn Thr Asp Glu Asp Thr 
145                 150                 155                 160 


Lys Lys Ile Leu Gln Lys Tyr Asn His Cys Arg Val Lys Ile Tyr Thr 
                165                 170                 175     


Phe Asn Gln Ser Arg Tyr Pro Arg Ile Asn Lys Glu Ser Leu Leu Pro 
            180                 185                 190         


Val Ala Lys Asp Val Ser Tyr Ser Gly Glu Asn Thr Glu Ala Trp Tyr 
        195                 200                 205             


Pro Pro Gly His Gly Asp Ile Tyr Ala Ser Phe Tyr Asn Ser Gly Leu 
    210                 215                 220                 


Leu Asp Thr Phe Ile Gly Glu Gly Lys Glu Tyr Ile Phe Val Ser Asn 
225                 230                 235                 240 


Ile Asp Asn Leu Gly Ala Thr Val Asp Leu Tyr Ile Leu Asn His Leu 
                245                 250                 255     


Met Asn Pro Pro Asn Gly Lys Arg Cys Glu Phe Val Met Glu Val Thr 
            260                 265                 270         


Asn Lys Thr Arg Ala Asp Val Lys Gly Gly Thr Leu Thr Gln Tyr Glu 
        275                 280                 285             


Gly Lys Leu Arg Leu Val Glu Ile Ala Gln Val Pro Lys Ala His Val 
    290                 295                 300                 


Asp Glu Phe Lys Ser Val Ser Lys Phe Lys Ile Phe Asn Thr Asn Asn 
305                 310                 315                 320 


Leu Trp Ile Ser Leu Ala Ala Val Lys Arg Leu Gln Glu Gln Asn Ala 
                325                 330                 335     


Ile Asp Met Glu Ile Ile Val Asn Ala Lys Thr Leu Asp Gly Gly Leu 
            340                 345                 350         


Asn Val Ile Gln Leu Glu Thr Ala Val Gly Ala Ala Ile Lys Ser Phe 
        355                 360                 365             


Glu Asn Ser Leu Gly Ile Asn Val Pro Arg Ser Arg Phe Leu Pro Val 
    370                 375                 380                 


Lys Thr Thr Ser Asp Leu Leu Leu Val Met Ser Asn Leu Tyr Ser Leu 
385                 390                 395                 400 


Asn Ala Gly Ser Leu Thr Met Ser Glu Lys Arg Glu Phe Pro Thr Val 
                405                 410                 415     


Pro Leu Val Lys Leu Gly Ser Ser Phe Thr Lys Val Gln Asp Tyr Leu 
            420                 425                 430         


Arg Arg Phe Glu Ser Ile Pro Asp Met Leu Glu Leu Asp His Leu Thr 
        435                 440                 445             


Val Ser Gly Asp Val Thr Phe Gly Lys Asn Val Ser Leu Lys Gly Thr 
    450                 455                 460                 


Val Ile Ile Ile Ala Asn His Gly Asp Arg Ile Asp Ile Pro Pro Gly 
465                 470                 475                 480 


Ala Val Leu Glu Asn Lys Ile Val Ser Gly Asn Leu Arg Ile Leu Asp 
                485                 490                 495     


His 
    


<210> 351
<211> 3013
<212> DNA
<213> Homo sapiens

<400> 351
gtgaaggaaa tagggacctg gccctgggcc ttgtgtagcg ggagggggag ctaggaagca       60

gctgagggca gaatccagga gggcctggct gcgggggaat gaagcctccg ccttcgcagg      120

caaaagcctt taaatacggg ctcaggcccg ggactcagag tgtaacgcgt ggcagcctga      180

gggaggggcg tgcgccgaga gggagctcag atcgagcggg gcgcgggtgg agaagctgcg      240

gcggcgcggc ccgtaggaag gtgctgtccg aacgatcggg ataggagcgg tccctgcgct      300

tgctgctggg aagtggtaca atcatgtttg aaattaagaa gatctgttgc atcggtgcag      360

gctatgttgg aggacccaca tgtagtgtca ttgctcatat gtgtcctgaa atcagggtaa      420

cggttgttga tgtcaatgaa tcaagaatca atgcgtggaa ttctcctaca cttcctattt      480

atgagccagg actaaaagaa gtggtagaat cctgtcgagg aaaaaatctt tttttttcta      540

ccaatattga tgatgccatc aaagaagctg atcttgtatt tatttctgtg ctgtccaacc      600

ctgagtttct ggcagaggga acagccatca aggacctaaa gaacccagac agagtactga      660

ttggagggga tgaaactcca gagggccaga gagctgtgca ggccctgtgt gctgtatatg      720

agcactgggt tcccagagaa aagatcctca ccactaatac ttggtcttca gagctttcca      780

aactggcagc aaatgctttt cttgcccaga gaataagcag cattaactcc ataagtgctc      840

tgtgtgaagc aacaggagct gatgtagaag aggtagcaac agcgattgga atggaccaga      900

gaattggaaa caagtttcta aaagccagtg ttgggtttgg tgggagctgt ttccaaaagg      960

atgttctgaa tttggtttat ctctgtgagg ctctgaattt gccagaagta gctcgttatt     1020

ggcagcaggt catagacatg aatgactacc agaggaggag gtttgcttcc cggatcatag     1080

atagtctgtt taatacagta actgataaga agatagctat tttgggattt gcattcaaaa     1140

aggacactgg tgatacaaga gaatcttcta gtatatatat tagcaaatat ttgatggatg     1200

aaggtgcaca tctacatata tatgatccaa aagtacctag ggaacaaata gttgtggatc     1260

tttctcatcc aggtgtttca gaggatgacc aagtgtcccg gctcgtgacc atttccaagg     1320

atccatatga agcatgtgat ggtgcccatg ctgttgttat ttgcactgag tgggacatgt     1380

ttaaggaatt ggattatgaa cgcattcata aaaaaatgct aaagccagcc tttatcttcg     1440

atggacggcg tgtcctggat gggctccaca atgaactaca aaccattggc ttccagattg     1500

aaacaattgg caaaaaggtg tcttcaaaga gaattccata tgctccttct ggtgaaattc     1560

cgaagtttag tcttcaagat ccacctaaca agaaacctaa agtgtagaga ttgccatttt     1620

tatttgtgat tttttttttt tttttttggt acttcaggat agcaaatatc tatctgctat     1680

taaatggtaa atgaaccaag tgtttttttt tgtttttttt ttgagacaga gtctcactgt     1740

tgcccaggct ggagtgcagt ggtgcaatct cggctcactg caagctctgc ttcccaggtt     1800

cacgccattc tcctggctca gcctcccaag tagctgggac tacaggcacc cgccacagtg     1860

cctggctaat tttttgtatt tttagtagag acagggtttc accatgtgag ccaggatggt     1920

ctcaatctcc tgaccttgtg aaccacccgt ctcggcctcc caaagtgctg ggattacagg     1980

tgtgagccac cacgcctggc ccatgaacca agtgttttta aggaaacaaa actatttttt     2040

taatcatcag atttatacta gctatatgga tattagcata tctggtaatt atgaatctag     2100

aattttttta catattttta taatactgtt agctcagtta ttggatgagt gaaagataat     2160

catgttggtt ttaatagtgt caatttttgt aaaataaaaa ttaaacttca aactctttac     2220

tttataaatt gtccataggc cacactttaa tatcacatta taaagggaag gacagtcttc     2280

attcctcctg gttattggtt tgtttgtcat taaagatata ttttgaatcc atgaaattgc     2340

tatgctaaac agcctttaca tgtatggtct ggttaaagtt cctttgttcc ttttgtttta     2400

ataaaatgtg tcactgattt tttagctcaa aatcatcact gttaatttcc agtcacccca     2460

aatatggtta aaagattttt tttttaatca tgaagagaaa attagtagca tttctttctc     2520

tccccattat ttattggttt tcctcactaa tctttttttt tttagtccaa aagccaaaaa     2580

tatttatctt ggttttacat tttaatttcc attcttaatt gtaatttttt tctttaaata     2640

aggaaaccaa tataatctca tgtataaaaa cttaaatatt ttacaagtta catatagcat     2700

cattctaaaa taagaatttt ttttgttttc tgtctgcttt tttcttatgt ctcttgttga     2760

gttttatatt ttcagtggtt atttttgctt gtgttagatc attattaaaa tatatccaat     2820

gtccctttga tacttgtgct ctgctgagaa tgtacagttt gcattaaaca tcccaggtct     2880

catccttcag gaattttgca gttcaatgag aagagggaga caaatataaa gatgaggaca     2940

gaagcatctc tacagatgaa aattacataa ataaaacatt ctccatcaac aactaaaaaa     3000

aaaaaaaaaa aaa                                                        3013


<210> 352
<211> 427
<212> PRT
<213> Homo sapiens

<400> 352
Met Phe Glu Ile Lys Lys Ile Cys Cys Ile Gly Ala Gly Tyr Val Gly 
1               5                   10                  15      


Gly Pro Thr Cys Ser Val Ile Ala His Met Cys Pro Glu Ile Arg Val 
            20                  25                  30          


Thr Val Val Asp Val Asn Glu Ser Arg Ile Asn Ala Trp Asn Ser Pro 
        35                  40                  45              


Thr Leu Pro Ile Tyr Glu Pro Gly Leu Lys Glu Val Val Glu Ser Cys 
    50                  55                  60                  


Arg Gly Lys Asn Leu Phe Phe Ser Thr Asn Ile Asp Asp Ala Ile Lys 
65                  70                  75                  80  


Glu Ala Asp Leu Val Phe Ile Ser Val Leu Ser Asn Pro Glu Phe Leu 
                85                  90                  95      


Ala Glu Gly Thr Ala Ile Lys Asp Leu Lys Asn Pro Asp Arg Val Leu 
            100                 105                 110         


Ile Gly Gly Asp Glu Thr Pro Glu Gly Gln Arg Ala Val Gln Ala Leu 
        115                 120                 125             


Cys Ala Val Tyr Glu His Trp Val Pro Arg Glu Lys Ile Leu Thr Thr 
    130                 135                 140                 


Asn Thr Trp Ser Ser Glu Leu Ser Lys Leu Ala Ala Asn Ala Phe Leu 
145                 150                 155                 160 


Ala Gln Arg Ile Ser Ser Ile Asn Ser Ile Ser Ala Leu Cys Glu Ala 
                165                 170                 175     


Thr Gly Ala Asp Val Glu Glu Val Ala Thr Ala Ile Gly Met Asp Gln 
            180                 185                 190         


Arg Ile Gly Asn Lys Phe Leu Lys Ala Ser Val Gly Phe Gly Gly Ser 
        195                 200                 205             


Cys Phe Gln Lys Asp Val Leu Asn Leu Val Tyr Leu Cys Glu Ala Leu 
    210                 215                 220                 


Asn Leu Pro Glu Val Ala Arg Tyr Trp Gln Gln Val Ile Asp Met Asn 
225                 230                 235                 240 


Asp Tyr Gln Arg Arg Arg Phe Ala Ser Arg Ile Ile Asp Ser Leu Phe 
                245                 250                 255     


Asn Thr Val Thr Asp Lys Lys Ile Ala Ile Leu Gly Phe Ala Phe Lys 
            260                 265                 270         


Lys Asp Thr Gly Asp Thr Arg Glu Ser Ser Ser Ile Tyr Ile Ser Lys 
        275                 280                 285             


Tyr Leu Met Asp Glu Gly Ala His Leu His Ile Tyr Asp Pro Lys Val 
    290                 295                 300                 


Pro Arg Glu Gln Ile Val Val Asp Leu Ser His Pro Gly Val Ser Glu 
305                 310                 315                 320 


Asp Asp Gln Val Ser Arg Leu Val Thr Ile Ser Lys Asp Pro Tyr Glu 
                325                 330                 335     


Ala Cys Asp Gly Ala His Ala Val Val Ile Cys Thr Glu Trp Asp Met 
            340                 345                 350         


Phe Lys Glu Leu Asp Tyr Glu Arg Ile His Lys Lys Met Leu Lys Pro 
        355                 360                 365             


Ala Phe Ile Phe Asp Gly Arg Arg Val Leu Asp Gly Leu His Asn Glu 
    370                 375                 380                 


Leu Gln Thr Ile Gly Phe Gln Ile Glu Thr Ile Gly Lys Lys Val Ser 
385                 390                 395                 400 


Ser Lys Arg Ile Pro Tyr Ala Pro Ser Gly Glu Ile Pro Lys Phe Ser 
                405                 410                 415     


Leu Gln Asp Pro Pro Asn Lys Lys Pro Lys Val 
            420                 425         


<210> 353
<211> 2342
<212> DNA
<213> Homo sapiens

<400> 353
tggcgcgggc aatccctcaa cctgattggt cccctcgccc gtcactccag tgcgccccca       60

acctaccacg cagtaaaagc cacccccgcc tcggcccgga cggtttccaa gctggttttg      120

aagtcgcggc agctgttcct gggacgtccg gttgaccgcg cgtctgctgc agagaccatg      180

tctgccgacg gggcagaggc tgatggcagc acccaggtga cagtggaaga accggtacag      240

cagcccagtg tggtggaccg tgtggccagc atgcctctga tcagctccac ctgcgacatg      300

gtgtccgcag cctatgcctc caccaaggag agctacccgc acatcaagac tgtctgcgac      360

gcagcagaga agggagtgag gaccctcacg gcggctgctg tcagcggggc tcagccgatc      420

ctctccaagc tggagcccca gattgcatca gccagcgaat acgcccacag ggggctggac      480

aagttggagg agaacctccc catcctgcag cagcccacgg agaaggtcct ggcggacacc      540

aaggagcttg tgtcgtctaa ggtgtcgggg gcccaagaga tggtgtctag cgccaaggac      600

acggtggcca cccaattgtc ggaggcggtg gacgcgaccc gcggtgctgt gcagagcggc      660

gtggacaaga caaagtccgt agtgaccggc ggcgtccaat cggtcatggg ctcccgcttg      720

ggccagatgg tgttgagtgg ggtcgacacg gtgctgggga agtcggagga gtgggcggac      780

aaccacctgc cccttacgga tgccgaactg gcccgcatcg ccacatccct ggatggcttt      840

gacgtcgcgt ccgtgcagca gcagcggcag gaacagagct acttcgtacg tctgggctcc      900

ctgtcggaga ggctgcggca gcacgcctat gagcactcgc tgggcaagct tcgagccacc      960

aagcagaggg cacaggaggc tctgctgcag ctgtcgcagg tcctaagcct gatggaaact     1020

gtcaagcaag gcgttgatca gaagctggtg gaaggccagg agaagctgca ccagatgtgg     1080

ctcagctgga accagaagca gctccagggc cccgagaagg agccgcccaa gccagaggtc     1140

gagtcccggg cgctcaccat gttccgggac attgcccagc aactgcaggc cacctgtacc     1200

tccctggggt ccagcattca gggcctcccc accaatgtga aggaccaggt gcagcaggcc     1260

cgccgccagg tggaggacct ccaggccacg ttttccagca tccactcctt ccaggacctg     1320

tccagcagca ttctggccca gagccgtgag cgtgtcgcca gcgcccgcga ggccctggac     1380

cacatggtgg aatatgtggc ccagaacaca cctgtcacgt ggctcgtggg accctttgcc     1440

cctggaatca ctgagaaagc cccggaggag aagaagtagg gggagaggag aggactcagc     1500

gggccccgtc tctataatgc agctgtgctc tggagtcctc aacccggggc tcatttcaaa     1560

cttattttct agccactcct cccagctctt ctgtgctgtc cacttgggaa gctaaggctc     1620

tcaaaacggg catcacccag ttgacccatc tctcagcctc tctgagcttg gaagaagcct     1680

gttctgagcc tcaccctatc agtcagtaga gagagatgtc cagaaaaaat atctttcagg     1740

aaagttctcc cctgcagaat tttttttcct tgttaaatat caggaatata ggccgggtgc     1800

ggtggctcac acctgtaatc ccagcacttt gggaggctga ggcgggcgga acacctgagg     1860

tcaggtgttc gagaccagcc aggccaacat ggtgaaaccc cgtctctact aaaaatacaa     1920

aaaaaaatga gccgggcatg gtagcaggtg tctgttatcc cagttaggag gctgaggcaa     1980

gagaatctct tgaacctgag aggcggaggt tgcagtgagc caagatcgcg ccattgcact     2040

ccagcctggg ggacaagagt gagacttagt ctcaaaaaaa aaaaaaaaga aaaaaaaatc     2100

agggatatag ttcatatccc acttctttgt ttacaccgat gtccctgaat atcagcctgt     2160

agctaatgga cttgggattt ctggtctaag tgggcctcct ggggatgggg tggtacactg     2220

agcttctgag cctcattgta gagtagaaag gtactggggc ctgtgtggta agccttgttg     2280

aaatgctctg gtattcagta ttgccttaat aaacttcacc cacaactgca tacaggcaaa     2340

aa                                                                    2342


<210> 354
<211> 433
<212> PRT
<213> Homo sapiens

<400> 354
Met Ser Ala Asp Gly Ala Glu Ala Asp Gly Ser Thr Gln Val Thr Val 
1               5                   10                  15      


Glu Glu Pro Val Gln Gln Pro Ser Val Val Asp Arg Val Ala Ser Met 
            20                  25                  30          


Pro Leu Ile Ser Ser Thr Cys Asp Met Val Ser Ala Ala Tyr Ala Ser 
        35                  40                  45              


Thr Lys Glu Ser Tyr Pro His Ile Lys Thr Val Cys Asp Ala Ala Glu 
    50                  55                  60                  


Lys Gly Val Arg Thr Leu Thr Ala Ala Ala Val Ser Gly Ala Gln Pro 
65                  70                  75                  80  


Ile Leu Ser Lys Leu Glu Pro Gln Ile Ala Ser Ala Ser Glu Tyr Ala 
                85                  90                  95      


His Arg Gly Leu Asp Lys Leu Glu Glu Asn Leu Pro Ile Leu Gln Gln 
            100                 105                 110         


Pro Thr Glu Lys Val Leu Ala Asp Thr Lys Glu Leu Val Ser Ser Lys 
        115                 120                 125             


Val Ser Gly Ala Gln Glu Met Val Ser Ser Ala Lys Asp Thr Val Ala 
    130                 135                 140                 


Thr Gln Leu Ser Glu Ala Val Asp Ala Thr Arg Gly Ala Val Gln Ser 
145                 150                 155                 160 


Gly Val Asp Lys Thr Lys Ser Val Val Thr Gly Gly Val Gln Ser Val 
                165                 170                 175     


Met Gly Ser Arg Leu Gly Gln Met Val Leu Ser Gly Val Asp Thr Val 
            180                 185                 190         


Leu Gly Lys Ser Glu Glu Trp Ala Asp Asn His Leu Pro Leu Thr Asp 
        195                 200                 205             


Ala Glu Leu Ala Arg Ile Ala Thr Ser Leu Asp Gly Phe Asp Val Ala 
    210                 215                 220                 


Ser Val Gln Gln Gln Arg Gln Glu Gln Ser Tyr Phe Val Arg Leu Gly 
225                 230                 235                 240 


Ser Leu Ser Glu Arg Leu Arg Gln His Ala Tyr Glu His Ser Leu Gly 
                245                 250                 255     


Lys Leu Arg Ala Thr Lys Gln Arg Ala Gln Glu Ala Leu Leu Gln Leu 
            260                 265                 270         


Ser Gln Val Leu Ser Leu Met Glu Thr Val Lys Gln Gly Val Asp Gln 
        275                 280                 285             


Lys Leu Val Glu Gly Gln Glu Lys Leu His Gln Met Trp Leu Ser Trp 
    290                 295                 300                 


Asn Gln Lys Gln Leu Gln Gly Pro Glu Lys Glu Pro Pro Lys Pro Glu 
305                 310                 315                 320 


Val Glu Ser Arg Ala Leu Thr Met Phe Arg Asp Ile Ala Gln Gln Leu 
                325                 330                 335     


Gln Ala Thr Cys Thr Ser Leu Gly Ser Ser Ile Gln Gly Leu Pro Thr 
            340                 345                 350         


Asn Val Lys Asp Gln Val Gln Gln Ala Arg Arg Gln Val Glu Asp Leu 
        355                 360                 365             


Gln Ala Thr Phe Ser Ser Ile His Ser Phe Gln Asp Leu Ser Ser Ser 
    370                 375                 380                 


Ile Leu Ala Gln Ser Arg Glu Arg Val Ala Ser Ala Arg Glu Ala Leu 
385                 390                 395                 400 


Asp His Met Val Glu Tyr Val Ala Gln Asn Thr Pro Val Thr Trp Leu 
                405                 410                 415     


Val Gly Pro Phe Ala Pro Gly Ile Thr Glu Lys Ala Pro Glu Glu Lys 
            420                 425                 430         


Lys 
    


<210> 355
<211> 1064
<212> DNA
<213> Homo sapiens

<400> 355
cgccgtcatt tcggagcgac tcagcgcctg cccgccctct cgccgcgtcg ccggtgcctg       60

cgcctcccgc tccacctcgc ttcttctctc ccggccgagg cccgggggac cagagcgaga      120

agcggggacc atgttccgac gcaagttgac ggctctcgac taccacaacc ccgccggctt      180

caactgcaaa gatgaaacag aatttagaaa cttcatcgtt tggcttgaag accagaaaat      240

caggcactac aagattgaag acagagggaa tttaagaaac atccacagca gcgactggcc      300

caagttcttt gaaaagtatc tcagagatgt taactgtcct ttcaagattc aagatcgaca      360

agaagctatt gactggcttc ttggtttagc tgttagactt gaatatggag ataatgctga      420

aaaatacaag gatttagtac ctgataattc aaaaactgct gacaatgcaa ctaaaaatgc      480

agaaccattg atcaatttgg atgtaaataa tcctgatttt aaggctggtg tgatggcttt      540

ggctaacctg cttcagattc agcgtcatga tgattacctg gtaatgctta aggcaattcg      600

gattttggtt caggagcgcc tgacacagga tgcagttgct aaggcaaatc aaacaaaaga      660

gggcttacct gttgctttag acaaacatat tcttggtttt gacacaggag atgcagttct      720

taatgaagct gctcaaattc tgcgattgct gcacatagag gagctcagag agctacagac      780

aaaaatcaac gaagccatag tagctgttca ggcaattatt gctgatccaa agacagacca      840

cagactggga aaagttggaa gatgaacact tgaggacttc agcttctcac ctacttagta      900

cagttgggaa ccatacactt ctggcatgtt tggaaatcaa aatgtcacat tctcggggga      960

ggaagcccag aaaattgggt atgttctaga gatttaccac cattgcttat tgcttttttc     1020

tttaataaag tttaggaaag tagaattttt aaaaaaaaaa aaaa                      1064


<210> 356
<211> 244
<212> PRT
<213> Homo sapiens

<400> 356
Met Phe Arg Arg Lys Leu Thr Ala Leu Asp Tyr His Asn Pro Ala Gly 
1               5                   10                  15      


Phe Asn Cys Lys Asp Glu Thr Glu Phe Arg Asn Phe Ile Val Trp Leu 
            20                  25                  30          


Glu Asp Gln Lys Ile Arg His Tyr Lys Ile Glu Asp Arg Gly Asn Leu 
        35                  40                  45              


Arg Asn Ile His Ser Ser Asp Trp Pro Lys Phe Phe Glu Lys Tyr Leu 
    50                  55                  60                  


Arg Asp Val Asn Cys Pro Phe Lys Ile Gln Asp Arg Gln Glu Ala Ile 
65                  70                  75                  80  


Asp Trp Leu Leu Gly Leu Ala Val Arg Leu Glu Tyr Gly Asp Asn Ala 
                85                  90                  95      


Glu Lys Tyr Lys Asp Leu Val Pro Asp Asn Ser Lys Thr Ala Asp Asn 
            100                 105                 110         


Ala Thr Lys Asn Ala Glu Pro Leu Ile Asn Leu Asp Val Asn Asn Pro 
        115                 120                 125             


Asp Phe Lys Ala Gly Val Met Ala Leu Ala Asn Leu Leu Gln Ile Gln 
    130                 135                 140                 


Arg His Asp Asp Tyr Leu Val Met Leu Lys Ala Ile Arg Ile Leu Val 
145                 150                 155                 160 


Gln Glu Arg Leu Thr Gln Asp Ala Val Ala Lys Ala Asn Gln Thr Lys 
                165                 170                 175     


Glu Gly Leu Pro Val Ala Leu Asp Lys His Ile Leu Gly Phe Asp Thr 
            180                 185                 190         


Gly Asp Ala Val Leu Asn Glu Ala Ala Gln Ile Leu Arg Leu Leu His 
        195                 200                 205             


Ile Glu Glu Leu Arg Glu Leu Gln Thr Lys Ile Asn Glu Ala Ile Val 
    210                 215                 220                 


Ala Val Gln Ala Ile Ile Ala Asp Pro Lys Thr Asp His Arg Leu Gly 
225                 230                 235                 240 


Lys Val Gly Arg 
                


<210> 357
<211> 1940
<212> DNA
<213> Homo sapiens

<400> 357
gcggttcggc gcggaaagcg ggaggtggag gggcggcttg gggcaagcgc gcgcgcgcag       60

tgcagaagcc agccccccgc ggctgaggta ctcaaggtgc ccaaaggcgg ggtagtgacc      120

tcgcgcgtgc gctgtgcccg cggcagcgcc gggtcctagt gtgtgggttg ttgttggcac      180

cgcacggcgc gtgcgcagtg aggacggcgg agggatttgc ggccgggacc caccccctgc      240

tccagtcgct atcggaggcc gcgcgggtgg ctgagcagcg gcctggtgcg ctcgcttagc      300

gggcgacgga atcagacgga cgtggacgcc cccggagtgg aagccgaagc aggagttgtt      360

gttgctgagg ggctgccgca gccgccgcga gcctccggac agacgccaga gcgaggaggg      420

cgctacgcga cttggcaaga tgacccagtt cctgccgccc aaccttctgg ccctctttgc      480

cccccgtgac cctattccat acctgccacc cctggagaaa ctgccacatg aaaaacacca      540

caatcaacct tattgtggca ttgcgccgta cattcgagag tttgaggacc ctcgagatgc      600

ccctcctcca actcgtgctg aaacccgaga ggagcgcatg gagaggaaaa gacgggaaaa      660

gattgagcgg cgacagcaag aagtggagac agagcttaaa atgtgggacc ctcacaatga      720

tcccaatgct cagggggatg ccttcaagac tctcttcgtg gcgagagtga attatgacac      780

aacagaatcc aagctccgga gagagtttga ggtgtacgga cctatcaaaa gaatacacat      840

ggtctacagt aagcggtcag gaaagccccg tggctatgcc ttcatcgagt acgaacacga      900

gcgagacatg cactccgctt acaaacacgc agatggcaag aagattgatg gcaggagggt      960

ccttgtggac gtggagaggg gccgaaccgt gaagggctgg aggccccggc ggctaggagg     1020

aggcctcggt ggtaccagaa gaggaggggc tgatgtgaac atccggcatt caggccgcga     1080

tgacacctcc cgctacgatg agaggcccgg cccctccccg cttccgcaca gggaccggga     1140

ccgggaccgt gagcgggagc gcagagagcg gagccgggag cgagacaagg agcgagaacg     1200

gcgacgctcc cgctcccggg accggcggag gcgctcacgg agtcgcgaca aggaggagcg     1260

gaggcgctcc agggagcgga gcaaggacaa ggaccgggac cggaagcggc gaagcagccg     1320

gagtcgggag cgggcccggc gggagcggga gcgcaaggag gagctgcgtg gcggcggtgg     1380

cgacatggcg gagccctccg aggcgggtga cgcgccccct gatgatgggc ctccagggga     1440

gctcgggcct gacggccctg acggtccaga ggaaaagggc cgggatcgtg accgggagcg     1500

acggcggagc caccggagcg agcgcgagcg gcgccgggac cgggatcgtg accgtgaccg     1560

tgaccgcgag cacaaacggg gggagcgggg cagtgagcgg ggcagggatg aggcccgagg     1620

tgggggcggt ggccaggaca acgggctgga gggtctgggc aacgacagcc gagacatgta     1680

catggagtct gagggcggcg acggctacct ggctccggag aatgggtatt tgatggaggc     1740

tgcgccggag tgaagaggtc gtcctctcca tctgctgtgt ttggacgcgt tcctgcccag     1800

ccccttgctg tcatcccctc ccccaacctt ggccacttga gtttgtcctc caagggtagg     1860

tgtctcattt gttctggccc cttggattta aaaataaaat taatttcctg ttgatagtgg     1920

gcaaaaaaaa aaaaaaaaaa                                                 1940


<210> 358
<211> 437
<212> PRT
<213> Homo sapiens

<400> 358
Met Thr Gln Phe Leu Pro Pro Asn Leu Leu Ala Leu Phe Ala Pro Arg 
1               5                   10                  15      


Asp Pro Ile Pro Tyr Leu Pro Pro Leu Glu Lys Leu Pro His Glu Lys 
            20                  25                  30          


His His Asn Gln Pro Tyr Cys Gly Ile Ala Pro Tyr Ile Arg Glu Phe 
        35                  40                  45              


Glu Asp Pro Arg Asp Ala Pro Pro Pro Thr Arg Ala Glu Thr Arg Glu 
    50                  55                  60                  


Glu Arg Met Glu Arg Lys Arg Arg Glu Lys Ile Glu Arg Arg Gln Gln 
65                  70                  75                  80  


Glu Val Glu Thr Glu Leu Lys Met Trp Asp Pro His Asn Asp Pro Asn 
                85                  90                  95      


Ala Gln Gly Asp Ala Phe Lys Thr Leu Phe Val Ala Arg Val Asn Tyr 
            100                 105                 110         


Asp Thr Thr Glu Ser Lys Leu Arg Arg Glu Phe Glu Val Tyr Gly Pro 
        115                 120                 125             


Ile Lys Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg 
    130                 135                 140                 


Gly Tyr Ala Phe Ile Glu Tyr Glu His Glu Arg Asp Met His Ser Ala 
145                 150                 155                 160 


Tyr Lys His Ala Asp Gly Lys Lys Ile Asp Gly Arg Arg Val Leu Val 
                165                 170                 175     


Asp Val Glu Arg Gly Arg Thr Val Lys Gly Trp Arg Pro Arg Arg Leu 
            180                 185                 190         


Gly Gly Gly Leu Gly Gly Thr Arg Arg Gly Gly Ala Asp Val Asn Ile 
        195                 200                 205             


Arg His Ser Gly Arg Asp Asp Thr Ser Arg Tyr Asp Glu Arg Pro Gly 
    210                 215                 220                 


Pro Ser Pro Leu Pro His Arg Asp Arg Asp Arg Asp Arg Glu Arg Glu 
225                 230                 235                 240 


Arg Arg Glu Arg Ser Arg Glu Arg Asp Lys Glu Arg Glu Arg Arg Arg 
                245                 250                 255     


Ser Arg Ser Arg Asp Arg Arg Arg Arg Ser Arg Ser Arg Asp Lys Glu 
            260                 265                 270         


Glu Arg Arg Arg Ser Arg Glu Arg Ser Lys Asp Lys Asp Arg Asp Arg 
        275                 280                 285             


Lys Arg Arg Ser Ser Arg Ser Arg Glu Arg Ala Arg Arg Glu Arg Glu 
    290                 295                 300                 


Arg Lys Glu Glu Leu Arg Gly Gly Gly Gly Asp Met Ala Glu Pro Ser 
305                 310                 315                 320 


Glu Ala Gly Asp Ala Pro Pro Asp Asp Gly Pro Pro Gly Glu Leu Gly 
                325                 330                 335     


Pro Asp Gly Pro Asp Gly Pro Glu Glu Lys Gly Arg Asp Arg Asp Arg 
            340                 345                 350         


Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu Arg Arg Arg Asp Arg 
        355                 360                 365             


Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly Glu Arg Gly 
    370                 375                 380                 


Ser Glu Arg Gly Arg Asp Glu Ala Arg Gly Gly Gly Gly Gly Gln Asp 
385                 390                 395                 400 


Asn Gly Leu Glu Gly Leu Gly Asn Asp Ser Arg Asp Met Tyr Met Glu 
                405                 410                 415     


Ser Glu Gly Gly Asp Gly Tyr Leu Ala Pro Glu Asn Gly Tyr Leu Met 
            420                 425                 430         


Glu Ala Ala Pro Glu 
        435         


<210> 359
<211> 2478
<212> DNA
<213> Homo sapiens

<400> 359
gaaagagtga gagccgccca cgagctctga gcagagagcc cgcaggagtg ccacgtcccg       60

gcggcctcgg cccctccctg cctcagtttc ccgtggcatc aaagggggcg aggggcccct      120

ccaggcctct ggtgacgggg gtgctgtgcc caggcggggg tccgggggcg accgaggggg      180

ctcaggaagt ccgcggccgc aggaattcgg cgcctccagg ccttataagg acatttgcgc      240

tccgggccaa tcagcggcgg gggcgtggcg cgcggagccc ggcgcgtccc aaccccgcgc      300

cagcccggcg gtcccgtccc gtcccgtcct gtgcggcccc gtcccgccgc ccgcccgcca      360

gccatgagct ccacgcagtt caacaagggc ccctcgtacg ggctgtcggc cgaggtcaag      420

aaccggctcc tgtccaaata tgacccccag aaggaggcag agctccgcac ctggatcgag      480

ggactcaccg gcctctccat cggccccgac ttccagaagg gcctgaagga tggaactatc      540

ttatgcacac tcatgaacaa gctacagccg ggctccgtcc ccaagatcaa ccgctccatg      600

cagaactggc accagctaga aaacctgtcc aacttcatca aggccatggt cagctacggc      660

atgaaccctg tggacctgtt cgaggccaac gacctgtttg agagtgggaa catgacgcag      720

gtgcaggtgt ctcttctcgc cctggcgggg aaggccaaga ctaaggggct gcagagcggg      780

gtggacattg gcgtcaagta ctcggagaag caggagcgga atttcgacga tgccaccatg      840

aaggctggcc agtgcgtcat cgggctgcag atgggcacca acaaatgcgc cagccagtcg      900

ggcatgactg cctacggcac gagaaggcat ctctatgacc ccaagaacca tatcctgccc      960

cccatggacc actcgaccat cagcctccag atgggcacga acaagtgtgc cagccaggtg     1020

ggcatgacgg ctcccgggac ccggcggcac atctatgata ccaagctggg aaccgacaag     1080

tgtgacaact cctccatgtc cctgcagatg ggctacacgc agggcgccaa ccagagcggc     1140

caggtcttcg gcctgggccg gcagatatat gaccccaagt actgcccgca aggcacagtg     1200

gccgatgggg ctccctcggg caccggcgac tgcccggacc cgggggaggt ccctgaatat     1260

cccccttact accaggagga ggccggctac tgaggctccc agcacgctct ctccccacat     1320

cgtctgccca tctgggtttt tgggtttttc tgtgttttca tctttttttt ttttttctta     1380

acccgttcag tgctgccagt caaccaaggg tctgtgagtg tcagcgtggg atcaggcagc     1440

agagcttttt tcccctttgc cttgatcctt cgcaaggctg agccactggg ctgtggggga     1500

aggggtcaag gccatatccc aatacgtgta gggcgagggt ccctgctggc acattcaggc     1560

tgtgctggga agaagagacc tgggcttgga aggaaccggt ccccgacggt ttctgcttgc     1620

ctcgcctctt cccccttttg tcagctgagc agtttgtggt ttctatgccc gcaagtttca     1680

ggaagtattc acaaaagaaa aatacatttt ttcccccagg ggtggggcaa ggacagtgga     1740

gagagtgcta ggaaatgagt cccctgggaa aggggaccgg gccgtgatgt taaatatctc     1800

cggctcccaa gtgactggat ttgcctagga ccttcagatc aacagacttc agaccctcag     1860

acctgccccg gggccaggtg gagaaagtga gggccgtaca aggaagtgaa attctgagtt     1920

gttggggcta agcctgaccc cctctccatg ctccccgccc caactcactc tggcctcagt     1980

agattttttt ttcagttgtg gttgttgccc aggctggagt gcagtggcgc catcttggct     2040

cactgcacct ccaccttccg ggctcaagcg attctccagc ctcagcctcc tgagtagcta     2100

ggactgcagg tgctccacca cgcccggcta atttttgtat ttttagtaga gatggggttt     2160

ccccatgttg gccaggctgg tctcgaactc ctggcctcag gtgtgatccg cccgcctccg     2220

cctccccaag cgctgagatt acaggtgtga gccaccgtgc ccaggccctc agtaggtttt     2280

aaggagtccc cagccctcct cccttctggg cccgaccagc ttatactgct ccatcttccc     2340

cggccacatg ccccgccaag tactgcacag ggacccccca cccaggggcc ctgctccgtg     2400

agataatgtg aaatacgact gtggaccaaa cgcaataaaa cctctgtttg tacgaagaaa     2460

aaaaaaaaaa aaaaaaaa                                                   2478


<210> 360
<211> 309
<212> PRT
<213> Homo sapiens

<400> 360
Met Ser Ser Thr Gln Phe Asn Lys Gly Pro Ser Tyr Gly Leu Ser Ala 
1               5                   10                  15      


Glu Val Lys Asn Arg Leu Leu Ser Lys Tyr Asp Pro Gln Lys Glu Ala 
            20                  25                  30          


Glu Leu Arg Thr Trp Ile Glu Gly Leu Thr Gly Leu Ser Ile Gly Pro 
        35                  40                  45              


Asp Phe Gln Lys Gly Leu Lys Asp Gly Thr Ile Leu Cys Thr Leu Met 
    50                  55                  60                  


Asn Lys Leu Gln Pro Gly Ser Val Pro Lys Ile Asn Arg Ser Met Gln 
65                  70                  75                  80  


Asn Trp His Gln Leu Glu Asn Leu Ser Asn Phe Ile Lys Ala Met Val 
                85                  90                  95      


Ser Tyr Gly Met Asn Pro Val Asp Leu Phe Glu Ala Asn Asp Leu Phe 
            100                 105                 110         


Glu Ser Gly Asn Met Thr Gln Val Gln Val Ser Leu Leu Ala Leu Ala 
        115                 120                 125             


Gly Lys Ala Lys Thr Lys Gly Leu Gln Ser Gly Val Asp Ile Gly Val 
    130                 135                 140                 


Lys Tyr Ser Glu Lys Gln Glu Arg Asn Phe Asp Asp Ala Thr Met Lys 
145                 150                 155                 160 


Ala Gly Gln Cys Val Ile Gly Leu Gln Met Gly Thr Asn Lys Cys Ala 
                165                 170                 175     


Ser Gln Ser Gly Met Thr Ala Tyr Gly Thr Arg Arg His Leu Tyr Asp 
            180                 185                 190         


Pro Lys Asn His Ile Leu Pro Pro Met Asp His Ser Thr Ile Ser Leu 
        195                 200                 205             


Gln Met Gly Thr Asn Lys Cys Ala Ser Gln Val Gly Met Thr Ala Pro 
    210                 215                 220                 


Gly Thr Arg Arg His Ile Tyr Asp Thr Lys Leu Gly Thr Asp Lys Cys 
225                 230                 235                 240 


Asp Asn Ser Ser Met Ser Leu Gln Met Gly Tyr Thr Gln Gly Ala Asn 
                245                 250                 255     


Gln Ser Gly Gln Val Phe Gly Leu Gly Arg Gln Ile Tyr Asp Pro Lys 
            260                 265                 270         


Tyr Cys Pro Gln Gly Thr Val Ala Asp Gly Ala Pro Ser Gly Thr Gly 
        275                 280                 285             


Asp Cys Pro Asp Pro Gly Glu Val Pro Glu Tyr Pro Pro Tyr Tyr Gln 
    290                 295                 300                 


Glu Glu Ala Gly Tyr 
305                 


<210> 361
<211> 1507
<212> DNA
<213> Homo sapiens

<400> 361
tgggcggcgg ctgaggcgcg tgctctcgcg tggtcgctgg gtctgcgtct tcccgagcca       60

gtgtgctgag ctctccgcgt cgcctctgtc gcccgcgcct ggcctaccgc ggcactcccg      120

gctgcacgct ctgcttggcc tcgccatgcc ggtggacctc agcaagtggt ccgggccctt      180

gagcctgcaa gaagtggacg agcagccgca gcacccgctg catgtcacct acgccggggc      240

ggcggtggac gagctgggca aagtgctgac gcccacccag gttaagaata gacccaccag      300

catttcgtgg gatggtcttg attcagggaa gctctacacc ttggtcctga cagacccgga      360

tgctcccagc aggaaggatc ccaaatacag agaatggcat catttcctgg tggtcaacat      420

gaagggcaat gacatcagca gtggcacagt cctctccgat tatgtgggct cggggcctcc      480

caagggcaca ggcctccacc gctatgtctg gctggtttac gagcaggaca ggccgctaaa      540

gtgtgacgag cccatcctca gcaaccgatc tggagaccac cgtggcaaat tcaaggtggc      600

gtccttccgt aaaaagtatg agctcagggc cccggtggct ggcacgtgtt accaggccga      660

gtgggatgac tatgtgccca aactgtacga gcagctgtct gggaagtagg gggttagctt      720

ggggacctga actgtcctgg aggccccaag ccatgttccc cagttcagtg ttgcatgtat      780

aatagatttc tcctcttcct gccccccttg gcatgggtga gacctgacca gtcagatggt      840

agttgagggt gacttttcct gctgcctggc ctttataatt ttactcactc actctgattt      900

atgttttgat caaatttgaa cttcattttg gggggtattt tggtactgtg atggggtcat      960

caaattatta atctgaaaat agcaacccag aatgtaaaaa agaaaaaact ggggggaaaa     1020

agaccaggtc tacagtgata gagcaaagca tcaaagaatc tttaagggag gtttaaaaaa     1080

aaaaaaaaaa aaaaagattg gttgcctctg cctttgtgat cctgagtcca gaatggtaca     1140

caatgtgatt ttatggtgat gtcactcacc tagacaacca gaggctggca ttgaggctaa     1200

cctccaacac agtgcatctc agatgcctca gtaggcatca gtatgtcact ctggtccctt     1260

taaagagcaa tcctggaaga agcaggaggg agggtggctt tgctgttgtt gggacatggc     1320

aatctagacc ggtagcagcg ctcgctgaca gcttgggagg aaacctgaga tctgtgtttt     1380

ttaaattgat cgttcttcat gggggtaaga aaagctggtc tggagttgct gaatgttgca     1440

ttaattgtgc tgtttgcttg tagttgaata aaaatagaaa cctgaatgaa gaaaaaaaaa     1500

aaaaaaa                                                               1507


<210> 362
<211> 187
<212> PRT
<213> Homo sapiens

<400> 362
Met Pro Val Asp Leu Ser Lys Trp Ser Gly Pro Leu Ser Leu Gln Glu 
1               5                   10                  15      


Val Asp Glu Gln Pro Gln His Pro Leu His Val Thr Tyr Ala Gly Ala 
            20                  25                  30          


Ala Val Asp Glu Leu Gly Lys Val Leu Thr Pro Thr Gln Val Lys Asn 
        35                  40                  45              


Arg Pro Thr Ser Ile Ser Trp Asp Gly Leu Asp Ser Gly Lys Leu Tyr 
    50                  55                  60                  


Thr Leu Val Leu Thr Asp Pro Asp Ala Pro Ser Arg Lys Asp Pro Lys 
65                  70                  75                  80  


Tyr Arg Glu Trp His His Phe Leu Val Val Asn Met Lys Gly Asn Asp 
                85                  90                  95      


Ile Ser Ser Gly Thr Val Leu Ser Asp Tyr Val Gly Ser Gly Pro Pro 
            100                 105                 110         


Lys Gly Thr Gly Leu His Arg Tyr Val Trp Leu Val Tyr Glu Gln Asp 
        115                 120                 125             


Arg Pro Leu Lys Cys Asp Glu Pro Ile Leu Ser Asn Arg Ser Gly Asp 
    130                 135                 140                 


His Arg Gly Lys Phe Lys Val Ala Ser Phe Arg Lys Lys Tyr Glu Leu 
145                 150                 155                 160 


Arg Ala Pro Val Ala Gly Thr Cys Tyr Gln Ala Glu Trp Asp Asp Tyr 
                165                 170                 175     


Val Pro Lys Leu Tyr Glu Gln Leu Ser Gly Lys 
            180                 185         


<210> 363
<211> 4450
<212> DNA
<213> Homo sapiens

<400> 363
agccgatggg ggcggggaaa agtccggctg ggccgggaca aaagccggat cccgggaagc       60

taccggctgc tggggtgctc cggattttgc ggggttcgtc gggcctgtgg aagaagcgcc      120

gcgcacggac ttcggcagag gtagagcagg tctctctgca gccatgtcgg ccaaggcaat      180

ttcagagcag acgggcaaag aactccttta caagttcatc tgtaccacct cagccatcca      240

gaatcggttc aagtatgctc gggtcactcc tgacacagac tgggcccgct tgctgcagga      300

ccacccctgg ctgctcagcc agaacttggt agtcaagcca gaccagctga tcaaacgtcg      360

tggaaaactt ggtctcgttg gggtcaacct cactctggat ggggtcaagt cctggctgaa      420

gccacggctg ggacaggaag ccacagttgg caaggccaca ggcttcctca agaactttct      480

gatcgagccc ttcgtccccc acagtcaggc tgaggagttc tatgtctgca tctatgccac      540

ccgagaaggg gactacgtcc tgttccacca cgaggggggt gtggacgtgg gtgatgtgga      600

cgccaaggcc cagaagctgc ttgttggcgt ggatgagaaa ctgaatcctg aggacatcaa      660

aaaacacctg ttggtccacg cccctgaaga caagaaagaa attctggcca gttttatctc      720

cggcctcttc aatttctacg aggacttgta cttcacctac ctcgagatca atccccttgt      780

agtgaccaaa gatggagtct atgtccttga cttggcggcc aaggtggacg ccactgccga      840

ctacatctgc aaagtgaagt ggggtgacat cgagttccct ccccccttcg ggcgggaggc      900

atatccagag gaagcctaca ttgcagacct cgatgccaaa agtggggcaa gcctgaagct      960

gaccttgctg aaccccaaag ggaggatctg gaccatggtg gccgggggtg gcgcctctgt     1020

cgtgtacagc gataccatct gtgatctagg gggtgtcaac gagctggcaa actatgggga     1080

gtactcaggc gcccccagcg agcagcagac ctatgactat gccaagacta tcctctccct     1140

catgacccga gagaagcacc cagatggcaa gatcctcatc attggaggca gcatcgcaaa     1200

cttcaccaac gtggctgcca cgttcaaggg catcgtgaga gcaattcgag attaccaggg     1260

ccccctgaag gagcacgaag tcacaatctt tgtccgaaga ggtggcccca actatcagga     1320

gggcttacgg gtgatgggag aagtcgggaa gaccactggg atccccatcc atgtctttgg     1380

cacagagact cacatgacgg ccattgtggg catggccctg ggccaccggc ccatccccaa     1440

ccagccaccc acagcggccc acactgcaaa cttcctcctc aacgccagcg ggagcacatc     1500

gacgccagcc cccagcagga cagcatcttt ttctgagtcc agggccgatg aggtggcgcc     1560

tgcaaagaag gccaagcctg ccatgccaca agattcagtc ccaagtccaa gatccctgca     1620

aggaaagagc accaccctct tcagccgcca caccaaggcc attgtgtggg gcatgcagac     1680

ccgggccgtg caaggcatgc tggactttga ctatgtctgc tcccgagacg agccctcagt     1740

ggctgccatg gtctaccctt tcactgggga ccacaagcag aagttttact gggggcacaa     1800

agagatcctg atccctgtct tcaagaacat ggctgatgcc atgaggaagc atccggaggt     1860

agatgtgctc atcaactttg cctctctccg ctctgcctat gacagcacca tggagaccat     1920

gaactatgcc cagatccgga ccatcgccat catagctgaa ggcatccctg aggccctcac     1980

gagaaagctg atcaagaagg cggaccagaa gggagtgacc atcatcggac ctgccactgt     2040

tggaggcatc aagcctgggt gctttaagat tggcaacaca ggtgggatgc tggacaacat     2100

cctggcctcc aaactgtacc gcccaggcag cgtggcctat gtctcacgtt ccggaggcat     2160

gtccaacgag ctcaacaata tcatctctcg gaccacggat ggcgtctatg agggcgtggc     2220

cattggtggg gacaggtacc cgggctccac attcatggat catgtgttac gctatcagga     2280

cactccagga gtcaaaatga ttgtggttct tggagagatt gggggcactg aggaatataa     2340

gatttgccgg ggcatcaagg agggccgcct cactaagccc atcgtctgct ggtgcatcgg     2400

gacgtgtgcc accatgttct cctctgaggt ccagtttggc catgctggag cttgtgccaa     2460

ccaggcttct gaaactgcag tagccaagaa ccaggctttg aaggaagcag gagtgtttgt     2520

gccccggagc tttgatgagc ttggagagat catccagtct gtatacgaag atctcgtggc     2580

caatggagtc attgtacctg cccaggaggt gccgccccca accgtgccca tggactactc     2640

ctgggccagg gagcttggtt tgatccgcaa acctgcctcg ttcatgacca gcatctgcga     2700

tgagcgagga caggagctca tctacgcggg catgcccatc actgaggtct tcaaggaaga     2760

gatgggcatt ggcggggtcc tcggcctcct ctggttccag aaaaggttgc ctaagtactc     2820

ttgccagttc attgagatgt gtctgatggt gacagctgat cacgggccag ccgtctctgg     2880

agcccacaac accatcattt gtgcgcgagc tgggaaagac ctggtctcca gcctcacctc     2940

ggggctgctc accatcgggg atcggtttgg gggtgccttg gatgcagcag ccaagatgtt     3000

cagtaaagcc tttgacagtg gcattatccc catggagttt gtgaacaaga tgaagaagga     3060

agggaagctg atcatgggca ttggtcaccg agtgaagtcg ataaacaacc cagacatgcg     3120

agtgcagatc ctcaaagatt acgtcaggca gcacttccct gccactcctc tgctcgatta     3180

tgcactggaa gtagagaaga ttaccacctc gaagaagcca aatcttatcc tgaatgtaga     3240

tggtctcatc ggagtcgcat ttgtagacat gcttagaaac tgtgggtcct ttactcggga     3300

ggaagctgat gaatatattg acattggagc cctcaatggc atctttgtgc tgggaaggag     3360

tatggggttc attggacact atcttgatca gaagaggctg aagcaggggc tgtatcgtca     3420

tccgtgggat gatatttcat atgttcttcc ggaacacatg agcatgtaac agagccagga     3480

accctactgc agtaaactga agacaagatc tcttccccca agaaaaagtg tacagacagc     3540

tggcagtgga gcctgcttta tttagcaggg gcctggaatg taaacagcca ctggggtaca     3600

ggcaccgaag accaacatcc acaggctaac accccttcag tccacacaaa gaagcttcat     3660

atttttttta taagcataga aataaaaacc aagccaatat ttgtgacttt gctctgctac     3720

ctgctgtatt tattatatgg aagcatctaa gtactgtcag gatggggtct tcctcattgt     3780

agggcgttag gatgttgctt tctttttcca ttagttaaac atttttttct cctttggagg     3840

aagggaatga aacatttatg gcctcaagat actatacatt taaagcaccc caatgtctct     3900

cttttttttt ttttacttcc ctttcttctt ccttatataa catgaagaac attgtattaa     3960

tctgattttt aaagatcttt ttgtatgtta cgtgttaagg gcttgtttgg tatcccactg     4020

aaatgttctg tgttgcagac cagagtctgt ttatgtcagg gggatggggc cattgcatcc     4080

ttagccattg tcacaaaata tgtggagtag taacttaata tgtaaagttg taacatacat     4140

acatttaaaa tggaaatgca gaaagctgtg aaatgtcttg tgtcttatgt tctctgtatt     4200

tatgcagctg atttgtctgt ctgtaactga agtgtgggtc caaggactcc taactacttt     4260

gcatctgtaa tccacaaaga ttctgggcag ctgccacctc agtctcttct ctgtattatc     4320

atagtctggt ttaaataaac tatatagtaa caaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4440

aaaaaaaaaa                                                            4450


<210> 364
<211> 1101
<212> PRT
<213> Homo sapiens

<400> 364
Met Ser Ala Lys Ala Ile Ser Glu Gln Thr Gly Lys Glu Leu Leu Tyr 
1               5                   10                  15      


Lys Phe Ile Cys Thr Thr Ser Ala Ile Gln Asn Arg Phe Lys Tyr Ala 
            20                  25                  30          


Arg Val Thr Pro Asp Thr Asp Trp Ala Arg Leu Leu Gln Asp His Pro 
        35                  40                  45              


Trp Leu Leu Ser Gln Asn Leu Val Val Lys Pro Asp Gln Leu Ile Lys 
    50                  55                  60                  


Arg Arg Gly Lys Leu Gly Leu Val Gly Val Asn Leu Thr Leu Asp Gly 
65                  70                  75                  80  


Val Lys Ser Trp Leu Lys Pro Arg Leu Gly Gln Glu Ala Thr Val Gly 
                85                  90                  95      


Lys Ala Thr Gly Phe Leu Lys Asn Phe Leu Ile Glu Pro Phe Val Pro 
            100                 105                 110         


His Ser Gln Ala Glu Glu Phe Tyr Val Cys Ile Tyr Ala Thr Arg Glu 
        115                 120                 125             


Gly Asp Tyr Val Leu Phe His His Glu Gly Gly Val Asp Val Gly Asp 
    130                 135                 140                 


Val Asp Ala Lys Ala Gln Lys Leu Leu Val Gly Val Asp Glu Lys Leu 
145                 150                 155                 160 


Asn Pro Glu Asp Ile Lys Lys His Leu Leu Val His Ala Pro Glu Asp 
                165                 170                 175     


Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser Gly Leu Phe Asn Phe Tyr 
            180                 185                 190         


Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile Asn Pro Leu Val Val Thr 
        195                 200                 205             


Lys Asp Gly Val Tyr Val Leu Asp Leu Ala Ala Lys Val Asp Ala Thr 
    210                 215                 220                 


Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly Asp Ile Glu Phe Pro Pro 
225                 230                 235                 240 


Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu Ala Tyr Ile Ala Asp Leu 
                245                 250                 255     


Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu Thr Leu Leu Asn Pro Lys 
            260                 265                 270         


Gly Arg Ile Trp Thr Met Val Ala Gly Gly Gly Ala Ser Val Val Tyr 
        275                 280                 285             


Ser Asp Thr Ile Cys Asp Leu Gly Gly Val Asn Glu Leu Ala Asn Tyr 
    290                 295                 300                 


Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln Gln Thr Tyr Asp Tyr Ala 
305                 310                 315                 320 


Lys Thr Ile Leu Ser Leu Met Thr Arg Glu Lys His Pro Asp Gly Lys 
                325                 330                 335     


Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn Phe Thr Asn Val Ala Ala 
            340                 345                 350         


Thr Phe Lys Gly Ile Val Arg Ala Ile Arg Asp Tyr Gln Gly Pro Leu 
        355                 360                 365             


Lys Glu His Glu Val Thr Ile Phe Val Arg Arg Gly Gly Pro Asn Tyr 
    370                 375                 380                 


Gln Glu Gly Leu Arg Val Met Gly Glu Val Gly Lys Thr Thr Gly Ile 
385                 390                 395                 400 


Pro Ile His Val Phe Gly Thr Glu Thr His Met Thr Ala Ile Val Gly 
                405                 410                 415     


Met Ala Leu Gly His Arg Pro Ile Pro Asn Gln Pro Pro Thr Ala Ala 
            420                 425                 430         


His Thr Ala Asn Phe Leu Leu Asn Ala Ser Gly Ser Thr Ser Thr Pro 
        435                 440                 445             


Ala Pro Ser Arg Thr Ala Ser Phe Ser Glu Ser Arg Ala Asp Glu Val 
    450                 455                 460                 


Ala Pro Ala Lys Lys Ala Lys Pro Ala Met Pro Gln Asp Ser Val Pro 
465                 470                 475                 480 


Ser Pro Arg Ser Leu Gln Gly Lys Ser Thr Thr Leu Phe Ser Arg His 
                485                 490                 495     


Thr Lys Ala Ile Val Trp Gly Met Gln Thr Arg Ala Val Gln Gly Met 
            500                 505                 510         


Leu Asp Phe Asp Tyr Val Cys Ser Arg Asp Glu Pro Ser Val Ala Ala 
        515                 520                 525             


Met Val Tyr Pro Phe Thr Gly Asp His Lys Gln Lys Phe Tyr Trp Gly 
    530                 535                 540                 


His Lys Glu Ile Leu Ile Pro Val Phe Lys Asn Met Ala Asp Ala Met 
545                 550                 555                 560 


Arg Lys His Pro Glu Val Asp Val Leu Ile Asn Phe Ala Ser Leu Arg 
                565                 570                 575     


Ser Ala Tyr Asp Ser Thr Met Glu Thr Met Asn Tyr Ala Gln Ile Arg 
            580                 585                 590         


Thr Ile Ala Ile Ile Ala Glu Gly Ile Pro Glu Ala Leu Thr Arg Lys 
        595                 600                 605             


Leu Ile Lys Lys Ala Asp Gln Lys Gly Val Thr Ile Ile Gly Pro Ala 
    610                 615                 620                 


Thr Val Gly Gly Ile Lys Pro Gly Cys Phe Lys Ile Gly Asn Thr Gly 
625                 630                 635                 640 


Gly Met Leu Asp Asn Ile Leu Ala Ser Lys Leu Tyr Arg Pro Gly Ser 
                645                 650                 655     


Val Ala Tyr Val Ser Arg Ser Gly Gly Met Ser Asn Glu Leu Asn Asn 
            660                 665                 670         


Ile Ile Ser Arg Thr Thr Asp Gly Val Tyr Glu Gly Val Ala Ile Gly 
        675                 680                 685             


Gly Asp Arg Tyr Pro Gly Ser Thr Phe Met Asp His Val Leu Arg Tyr 
    690                 695                 700                 


Gln Asp Thr Pro Gly Val Lys Met Ile Val Val Leu Gly Glu Ile Gly 
705                 710                 715                 720 


Gly Thr Glu Glu Tyr Lys Ile Cys Arg Gly Ile Lys Glu Gly Arg Leu 
                725                 730                 735     


Thr Lys Pro Ile Val Cys Trp Cys Ile Gly Thr Cys Ala Thr Met Phe 
            740                 745                 750         


Ser Ser Glu Val Gln Phe Gly His Ala Gly Ala Cys Ala Asn Gln Ala 
        755                 760                 765             


Ser Glu Thr Ala Val Ala Lys Asn Gln Ala Leu Lys Glu Ala Gly Val 
    770                 775                 780                 


Phe Val Pro Arg Ser Phe Asp Glu Leu Gly Glu Ile Ile Gln Ser Val 
785                 790                 795                 800 


Tyr Glu Asp Leu Val Ala Asn Gly Val Ile Val Pro Ala Gln Glu Val 
                805                 810                 815     


Pro Pro Pro Thr Val Pro Met Asp Tyr Ser Trp Ala Arg Glu Leu Gly 
            820                 825                 830         


Leu Ile Arg Lys Pro Ala Ser Phe Met Thr Ser Ile Cys Asp Glu Arg 
        835                 840                 845             


Gly Gln Glu Leu Ile Tyr Ala Gly Met Pro Ile Thr Glu Val Phe Lys 
    850                 855                 860                 


Glu Glu Met Gly Ile Gly Gly Val Leu Gly Leu Leu Trp Phe Gln Lys 
865                 870                 875                 880 


Arg Leu Pro Lys Tyr Ser Cys Gln Phe Ile Glu Met Cys Leu Met Val 
                885                 890                 895     


Thr Ala Asp His Gly Pro Ala Val Ser Gly Ala His Asn Thr Ile Ile 
            900                 905                 910         


Cys Ala Arg Ala Gly Lys Asp Leu Val Ser Ser Leu Thr Ser Gly Leu 
        915                 920                 925             


Leu Thr Ile Gly Asp Arg Phe Gly Gly Ala Leu Asp Ala Ala Ala Lys 
    930                 935                 940                 


Met Phe Ser Lys Ala Phe Asp Ser Gly Ile Ile Pro Met Glu Phe Val 
945                 950                 955                 960 


Asn Lys Met Lys Lys Glu Gly Lys Leu Ile Met Gly Ile Gly His Arg 
                965                 970                 975     


Val Lys Ser Ile Asn Asn Pro Asp Met Arg Val Gln Ile Leu Lys Asp 
            980                 985                 990         


Tyr Val Arg Gln His Phe Pro Ala  Thr Pro Leu Leu Asp  Tyr Ala Leu 
        995                 1000                 1005             


Glu Val  Glu Lys Ile Thr Thr  Ser Lys Lys Pro Asn  Leu Ile Leu 
    1010                 1015                 1020             


Asn Val  Asp Gly Leu Ile Gly  Val Ala Phe Val Asp  Met Leu Arg 
    1025                 1030                 1035             


Asn Cys  Gly Ser Phe Thr Arg  Glu Glu Ala Asp Glu  Tyr Ile Asp 
    1040                 1045                 1050             


Ile Gly  Ala Leu Asn Gly Ile  Phe Val Leu Gly Arg  Ser Met Gly 
    1055                 1060                 1065             


Phe Ile  Gly His Tyr Leu Asp  Gln Lys Arg Leu Lys  Gln Gly Leu 
    1070                 1075                 1080             


Tyr Arg  His Pro Trp Asp Asp  Ile Ser Tyr Val Leu  Pro Glu His 
    1085                 1090                 1095             


Met Ser  Met 
    1100     


<210> 365
<211> 2440
<212> DNA
<213> Homo sapiens

<400> 365
ttttgattgc catttccttg ggacagcctg aagagagaat cgaaagaagt tcttttcagt       60

atggttgcat aacatcgagt cggagattgt gaaatgtcct ttgagaaaaa tgtacgggca      120

ggaagatgaa taggtgtctg tttgattaag gctctccttc ggaaagatgt cggacacggc      180

agtagctgat acccggcgcc ttaactcgaa gccgcaggac ctgaccgacg cttacgggcc      240

gccaagtaac ttcctggaga tcgacatctt taatcctcag acggtgggcg tgggacgcgc      300

gcgcttcacc acctatgagg ttcgcatgcg gacaaaccta cctatcttca agctaaagga      360

gtcctgcgta cggcggcgct acagtgactt tgagtggctg aaaaatgagc tggagagaga      420

tagcaagatt gtagtaccac cactgcctgg gaaagccttg aagcggcagc tccctttccg      480

aggagatgaa gggatctttg aggagtcttt catcgaagaa aggaggcagg gcctcgagca      540

gtttattaac aaaattgctg ggcacccact ggctcagaat gaacgctgcc tacacatgtt      600

cctgcaagag gaggcaattg acaggaacta cgtcccgggg aaggtgcgcc agtaggagcc      660

cctctcacca cctgccctct actttcctgc tgaaatgaca ttggttttta cactaagcct      720

ctctctgtct ttgatctgaa gttggctgcc catctcctgg cctgatagac tgtctggcat      780

tgtgctccct ggtacctgac tacaccatgt gggcactctg ctaggatcct cttctctgag      840

gagaggtggg aacccacagg cagatgccct ttgcttgggg ttggggtggg tgggtggggg      900

gattagactg gaaggcaatt tcttgggcat ttacccatgc cagaaggcta acctgggggg      960

aggggggcgc ttgtgctggt gaggcacttg gatacatact gatgctgcaa gttcagggga     1020

tttttcttac tcttaggttt aaccaagaac actgagcagg gaaaaaccct gcctttccta     1080

actgcatgta ttttttcctt tttggaaagg tggtagagac tcagaagctt tccttgtttt     1140

cttcaggcct gctcccagtt ttcttaacag tttcttttgt tgctttctct ctcccttgtt     1200

gctttccatg gcagtaatcc tcctagagtc caagcagtct gttgtatgga gcagggtgtg     1260

tgggttttct gggcccatca ttatggctgc ttcagagtca gaagaaagcc atagggcagt     1320

aggggagctc ctattgccta gcccctctcc ctttgtggct cccactctag ctgcctattt     1380

ttgctcatca gctggtgagt cagtatgggc cagcagttct ccctccctaa gcccttgcta     1440

ctttatgggt tagctttgca ggtttggtgg cttgaggggt gggggcaact caccactgcc     1500

aggtaactcc ctgaagggtg ggagtggatt atcttctagg ctcttacccg cggtagggaa     1560

gggcatcaac actgtcttcc ttccattctc ctttccccca tcccatttag tgctgccaca     1620

gggcagaagc acacaaacca accacacagt ctctgacttc tcctaagcac tttgagttgt     1680

tgaatggggc tcaggggcaa gagtttttgc tgccctcccc agcgtggtca cagggttatt     1740

gaactgcctg cacttgtttc tcatgcaact ccagcatttt ccccagaagt tgaactatgg     1800

atagcagctt ggtatggatt tcctaaatct taacatttga agcagcttct tgaggctggc     1860

aactatcctg gtttctgtct tggagggggt ggtttgtttg ctggggccca acgtctgtcc     1920

caagtggtgg ggtgagagta agttaacttt ggtgccaggt gagaggtggg ggctctttgc     1980

ttagactccc tatcatggaa agattggagt tttctatgca gggcactgtg gaaaaggatt     2040

gctgattctg actgaccctg atcagagaga ttaggattgt attttgacat aggatttgga     2100

acccatctaa atgttgaagt tccctgagac agctctccag ctgctgagcc tgcgccaggg     2160

gctaagcagc ccctaatgag aggctctgct ccctttccca cctcgccaat gttgttgttg     2220

ctgccttttt gatttgtatc ctctgttata gacatttttt aaaaacgatt tcctctttca     2280

ttgtgcacaa gtgctgagag tctgaggccc catttctgct gtgtatatat atcctgactc     2340

ggggctttta ttcagcaaac tgttcattct tctgtcagac aatgtcatat tcaactctgt     2400

tcatattaaa ccactgtgaa gcaaaaaaaa aaaaaaaaaa                           2440


<210> 366
<211> 162
<212> PRT
<213> Homo sapiens

<400> 366
Met Ser Asp Thr Ala Val Ala Asp Thr Arg Arg Leu Asn Ser Lys Pro 
1               5                   10                  15      


Gln Asp Leu Thr Asp Ala Tyr Gly Pro Pro Ser Asn Phe Leu Glu Ile 
            20                  25                  30          


Asp Ile Phe Asn Pro Gln Thr Val Gly Val Gly Arg Ala Arg Phe Thr 
        35                  40                  45              


Thr Tyr Glu Val Arg Met Arg Thr Asn Leu Pro Ile Phe Lys Leu Lys 
    50                  55                  60                  


Glu Ser Cys Val Arg Arg Arg Tyr Ser Asp Phe Glu Trp Leu Lys Asn 
65                  70                  75                  80  


Glu Leu Glu Arg Asp Ser Lys Ile Val Val Pro Pro Leu Pro Gly Lys 
                85                  90                  95      


Ala Leu Lys Arg Gln Leu Pro Phe Arg Gly Asp Glu Gly Ile Phe Glu 
            100                 105                 110         


Glu Ser Phe Ile Glu Glu Arg Arg Gln Gly Leu Glu Gln Phe Ile Asn 
        115                 120                 125             


Lys Ile Ala Gly His Pro Leu Ala Gln Asn Glu Arg Cys Leu His Met 
    130                 135                 140                 


Phe Leu Gln Glu Glu Ala Ile Asp Arg Asn Tyr Val Pro Gly Lys Val 
145                 150                 155                 160 


Arg Gln 
        


<210> 367
<211> 6774
<212> DNA
<213> Homo sapiens

<400> 367
cggcgtgagc ttcggccgcc attttacaac agctccactc gcgccggaca cagggagcag       60

cgagcacgcg tttcccgcaa cccgatacca tcggacagga tttctccgcc tcagcccaac      120

ggggagggct agttgcacat agtgatttag atgaaagagc tattgaagct ttaaaagaat      180

tcaatgaaga cggtgcattg gcagttcttc aacagtttaa agacagtgat ctctctcatg      240

ttcagaacaa aagtgccttt ttatgtggag tcatgaagac ttacaggcag agagaaaaac      300

aagggaccaa agtagcagat tctagtaaag gaccagatga ggcaaaaatt aaggcactct      360

tggaaagaac aggctacaca cttgatgtga ccactggaca gaggaagtat ggaggaccac      420

ctccagattc cgtttattca ggtcagcagc cttctgttgg cactgagata tttgtgggaa      480

agatcccaag agatctattt gaggatgaac ttgttccatt atttgagaaa gctggaccta      540

tatgggatct tcgtctaatg atggatccac tcactggtct caatagaggt tatgcgtttg      600

tcactttttg tacaaaagaa gcagctcagg aggctgttaa actgtataat aatcatgaaa      660

ttcgttctgg aaaacatatt ggtgtctgca tctcagttgc caacaatagg ctttttgtgg      720

gctctattcc taagagtaaa accaaggaac agattcttga agaatttagc aaagtaacag      780

agggtcttac agacgtcatt ttataccacc aaccggatga caagaaaaaa aacagaggct      840

tttgctttct tgaatatgaa gatcacaaaa cagctgccca ggcaaggcgt aggttaatga      900

gtggtaaagt caaggtctgg gggaatgttg gaactgttga atgggctgat cctatagaag      960

atcctgatcc tgaggttatg gcaaaggtaa aagtgctgtt tgtacgcaac cttgccaata     1020

ctgtaacaga agagatttta gaaaaggcat ttagtcagtt tgggaaactg gaacgagtga     1080

agaagttaaa agattatgcg ttcattcatt ttgatgagcg agatggtgct gtcaaggcta     1140

tggaagaaat gaatggcaaa gacttggagg gagaaaatat tgaaattgtt tttgccaagc     1200

caccagatca gaaaaggaaa gaaagaaaag ctcagaggca agcagcaaaa aatcaaatgt     1260

atgacgatta ctactattat ggtccacctc atatgccccc tccaacaaga ggtcgagggc     1320

gtggaggtag aggtggttat ggatatcctc cagattatta tggatatgaa gattattatg     1380

attattatgg ttatgattac cataactatc gtggtggata tgaagatcca tactatggtt     1440

atgaagattt tcaagttgga gctagaggaa ggggtggtag aggagcaagg ggtgctgctc     1500

catccagagg tcgtggggct gctcctcccc gcggtagagc cggttattca cagagaggag     1560

gtcctggatc agcaagaggc gttcgaggtg cgagaggagg tgcccaacaa caaagaggcc     1620

gcgggcaggg aaaaggggtc gaggccggtc ctgacctgtt acaatgaaga ctgacttgct     1680

atgtgggatt acaccagaag cttgcagtgg agtaatggta aggaaatcaa gcaaccttaa     1740

atatgtcggc tgtataggag catattctat tgcagaagac cttcctatga agatcatgga     1800

atcaaatacg ggacattgaa ctaatacttg gactttgata tgaatttctt taacaatttt     1860

ctctgcagtg caagttatta aactaaagct actctatttt caaaatgtgt tccaacagaa     1920

atccttcata actcctagca tggtatctta ataaagaata aagttctttt aaaaatctgc     1980

tctaagtaga tttttcccct tttttaaatt aaggatccca acagtggtat tttgaaatat     2040

tctcttgaat ttgtgcattt aaattttatt gcagtggtat agatgaatgc cactgatggt     2100

atccttaaat tttatttctg ctcaccaagg ttaatcatga ttgtctatat cttttttata     2160

gtgatcactt ttgaattgtg ttcagatatg cagtttcagg tgtaatcatc agagctggtt     2220

agtcaggcat tccagatagt ggttcttttc agaacctttt taaaagggtt ggttaactac     2280

ctcagtagca gaggattgaa ctataccctg tctgtactgt acatagaaaa tctttgtaga     2340

taaaagcaag gcttgttaaa tatgatatga gggtaagatt ttaatatacc aaatgtaaca     2400

ttcttagttg cctttagttt cagaggcttg taagacttcc tcatgaccat cataacaggc     2460

cttgcttttg tcgtattttg tggctgaaaa agcagccttg cttcttcaga tattgtagtt     2520

atttggatgt ataatagttt agcaagatgt tacttttgta agacatcaga tgttcaaaaa     2580

agtgcatccg aacttgtact aaatactgca gtgtcccttt ataaaaagtc agactaaaac     2640

tgacaattgt acagcgaagc ctgacatttg gatattttga agttttttca taaatcatag     2700

aaattagtat atggctgtag tttagctttt taggtaaaag gtatgtttca ttagtgcatt     2760

tcttcctgct gatcactgta aacatgtgaa tcagctttcc atttcttatg caggtcatga     2820

taacttgtag agtagagtac aatcatttgt gctatgtttt taattttcta aagcaccttg     2880

atgacagtga gtgtccagtg gtgaagcatc ctctattgaa ccaccctcaa aaattttttt     2940

gccaagtcct aagttgatag cttaaagtaa aaagtgaaaa ttatagtttc attaggactt     3000

ggtgtaaaga aatcccctcc ccccttcccc aaagggatac tgcagttata tcacataccc     3060

aataggcacc acgatgaaga tcagagctta tacttaatta aggttttata cacaccagtt     3120

ccccagtaaa tgcaaattta acaagaaaat cagacatgtc atatgttcaa aatgctcatg     3180

gcaaacaatc attttgcatt cctgcaaata aaattgtttt atactgtaag ctggaggcga     3240

gtgtaactta tttttgtaat aaagttttta ttttttttat gtgtcattaa tataaatgtg     3300

tgttagtgta gaaatcttct ggtttaaaaa cttagaattg cacacatttc agtatgttta     3360

tttgtactta cataatttta gaatagtggt tgccaatagc ctgtatgttt cacattaatt     3420

ggttttttgt tatctaaata aatcatttta gtatgttgta tgtcagttac tgggatagct     3480

gggacataga gtgtaattta aaatttgtca ataagtattc attggaatat atgtaaatgt     3540

gccttgccgg ttattgaaac ttatctacaa aatgagtatg gggtgacaaa aattagttcc     3600

tggtgcttaa tgaaactttc tgccactgat tttatatatt accccgtgct tttttaaagt     3660

acatctctct caaaacttag tgtaagtttg agggctacac aaaacattta catttcattc     3720

taacataatg aatataatag gttgtggaaa gtgggtaaac taaatgtagc cttcagtaaa     3780

attgaatctc agtgtaatcc ttggtgctgg catttctcag ttccgaggag ttaaatgatc     3840

ccatctaaga ggtcattgcc atgcctattg gcactttact gtcatagcat ttttaaggga     3900

cactgtcaag gtgtttaagt tctcagaatt acttgttggg attttaggac aggtttgttt     3960

acttaaagta agaactgcat tgtcaaagtt gaaagaggaa cacttttgtg agttcacaaa     4020

tgtgttctta agaaaacatt aaaatatgga gctctgggtt ttcaagacta tttggcattc     4080

ttaatttggg gacttgggag ggaaactgat aaaaagaaat tgaagaattg atggttatac     4140

ttaaagaagg gtaatgtaaa cagtggtgat gaaatatata cacatcaagt gaaattactt     4200

gacagtgttc atttgaatga ctttgaattc aagccattat aattactttt aaaattaaat     4260

atcatttgca ctgttctgat aatgggtgca gtttttgagc aatataatca gagctaaata     4320

tgcatgtagt gattagtgat gtgaacaatt aacgttctga gaagaaatac taactgtggt     4380

attttcaaac ttaaatttct gtagtaaaat cagtatcaaa gtcttatcag atcaaggaaa     4440

aacaggcaat gcatataaac atacttttga atgttgtgtg gcctataaag caataatgca     4500

atttatatgg aatgtcatgg gatatgagaa atggaaatgc aaaaataact aatcctttag     4560

taaaaatgtc aacatgttaa agggggaatg ttaactaatg taggttattg ctatttgtga     4620

tttgtttatg ggttcttggc tttgacagct tcaaagaatg gacagtgata agttaaaaga     4680

aattttgtat attgtcaagg aaagggtctt aaatccgagt caagtccctt ccttggggta     4740

aaaaatgtat tcttaaagca ttctgatgtt aaaaagaaaa cttaagttat ctaaccaaaa     4800

cagacgcaag attttgtttc tgcagactac ttggcaatca aaagtgatca taaatttagg     4860

ttatcagttt tcagaaagtt gctttgtgag aaaattttgt tagatatatt ctcccaagca     4920

tgctttttgt ggaaggtttt cagccattgc cactgaatca gatgttaaaa atgaagggaa     4980

aattgagtgt gcacacacac aactgttgta cactcatgat tgcagttttt agcttaagaa     5040

acttttctac cagttactgt gaatctgact taaaatgtaa agtttcctca tgataaaata     5100

ggaacaacat agaaatggat tgatggggtg atctgagtta ttgtatataa aagtttttaa     5160

agaatagaat gaacatcaag ctagataggc aaaaattgac acattcagaa cagctttttt     5220

gactgcgaag ccaaaagttg tcagaaacag caaaagatcc cttattatta cagagtattt     5280

tacgtagtct ctattttaag gagagaaatt aaatagaagg gcttcatgca tttaggggag     5340

ggtgctaaaa cttctcaagt tcgtcaaact tacaggaata cccaccatga tcattttctc     5400

tctaattatg tataccacaa aattttcatc tggccatagg aattcactgg tgggtgtaaa     5460

attaatgact aaagaaatta agtgacaaat acataaaaga aacagacttg tggggatatt     5520

gttttaaggt gtattaatta ctcagtgatg ataccactca atagggcatg ccactacttt     5580

tcttaagatg ctaattatga agcagtgctc acaggcattt tttaactagc aaattagtag     5640

atggactttt ggggtctgtc actttttaaa agtatttaag acttaaattc tattagcacc     5700

acagtctgcc ttcagtaata cacctaaaat atttttcagg accagaagca ttcagtttga     5760

aaatttgcag atgcaaacca gtattattac taacgctctg ggtcaaagat taggttttta     5820

atattaacag tagtctggta aatatttaga agtctggcat tgagaaacaa aagcttgtac     5880

ctgactagta tttttattta aaaaaattag ttctgttagc ttatttaaat tgtgttttat     5940

ttatccgtag aatttatatt tatttcattc ctttcatctc actgaaaact gtctgcaggc     6000

cctttgattt ggattagatg tgtgaagtac tgtcttttgc caaaaacctc aaattacctg     6060

ttcttttcaa cgtagtgggt ttgtgcttgt ttggagatca gttcaaaaac tatctgtact     6120

atctgtactg cctctgatgt taagatttta tgtatagcat aaggaagcta gctctgacta     6180

tattttccta agaataaaga cctatttttg tagcatgtct taggatctcc aggagtccaa     6240

gaattattgt gggtgtcctc caattcatca ctcttcactt aacagctttt aagtagacac     6300

ttggaatctt tagaggtctg tcgccctttg attatccata cattcgaagt aactagccaa     6360

tggtgaaaaa ttcctcaaga tatcctcagt tgcaatcaca ttactggaag atgaatagaa     6420

taaatgtatt aggctggtct taatttttga tggaaatatt ctgttgtccc gtacttgcca     6480

ttggatttga taaagttagt ggtaatttgg aaagaatcgg ggacttgcca atatatttgt     6540

gggttttagc ttatacccct aggatttctt ggttgcggga cgagcagttt tggccacttc     6600

catcaggaca agacttttta ggtcacttag tgcaggtttt agtttctatt ttggattaac     6660

aacatttata ttgattatcg aaaagaagct ttcatcattt cagaacagtc ctggaagttt     6720

gactttgagt gtgggagaag tcctaataaa ccattttgga aattaaaaaa aaaa           6774


<210> 368
<211> 464
<212> PRT
<213> Homo sapiens

<400> 368
Met Lys Thr Tyr Arg Gln Arg Glu Lys Gln Gly Thr Lys Val Ala Asp 
1               5                   10                  15      


Ser Ser Lys Gly Pro Asp Glu Ala Lys Ile Lys Ala Leu Leu Glu Arg 
            20                  25                  30          


Thr Gly Tyr Thr Leu Asp Val Thr Thr Gly Gln Arg Lys Tyr Gly Gly 
        35                  40                  45              


Pro Pro Pro Asp Ser Val Tyr Ser Gly Gln Gln Pro Ser Val Gly Thr 
    50                  55                  60                  


Glu Ile Phe Val Gly Lys Ile Pro Arg Asp Leu Phe Glu Asp Glu Leu 
65                  70                  75                  80  


Val Pro Leu Phe Glu Lys Ala Gly Pro Ile Trp Asp Leu Arg Leu Met 
                85                  90                  95      


Met Asp Pro Leu Thr Gly Leu Asn Arg Gly Tyr Ala Phe Val Thr Phe 
            100                 105                 110         


Cys Thr Lys Glu Ala Ala Gln Glu Ala Val Lys Leu Tyr Asn Asn His 
        115                 120                 125             


Glu Ile Arg Ser Gly Lys His Ile Gly Val Cys Ile Ser Val Ala Asn 
    130                 135                 140                 


Asn Arg Leu Phe Val Gly Ser Ile Pro Lys Ser Lys Thr Lys Glu Gln 
145                 150                 155                 160 


Ile Leu Glu Glu Phe Ser Lys Val Thr Glu Gly Leu Thr Asp Val Ile 
                165                 170                 175     


Leu Tyr His Gln Pro Asp Asp Lys Lys Lys Asn Arg Gly Phe Cys Phe 
            180                 185                 190         


Leu Glu Tyr Glu Asp His Lys Thr Ala Ala Gln Ala Arg Arg Arg Leu 
        195                 200                 205             


Met Ser Gly Lys Val Lys Val Trp Gly Asn Val Gly Thr Val Glu Trp 
    210                 215                 220                 


Ala Asp Pro Ile Glu Asp Pro Asp Pro Glu Val Met Ala Lys Val Lys 
225                 230                 235                 240 


Val Leu Phe Val Arg Asn Leu Ala Asn Thr Val Thr Glu Glu Ile Leu 
                245                 250                 255     


Glu Lys Ala Phe Ser Gln Phe Gly Lys Leu Glu Arg Val Lys Lys Leu 
            260                 265                 270         


Lys Asp Tyr Ala Phe Ile His Phe Asp Glu Arg Asp Gly Ala Val Lys 
        275                 280                 285             


Ala Met Glu Glu Met Asn Gly Lys Asp Leu Glu Gly Glu Asn Ile Glu 
    290                 295                 300                 


Ile Val Phe Ala Lys Pro Pro Asp Gln Lys Arg Lys Glu Arg Lys Ala 
305                 310                 315                 320 


Gln Arg Gln Ala Ala Lys Asn Gln Met Tyr Asp Asp Tyr Tyr Tyr Tyr 
                325                 330                 335     


Gly Pro Pro His Met Pro Pro Pro Thr Arg Gly Arg Gly Arg Gly Gly 
            340                 345                 350         


Arg Gly Gly Tyr Gly Tyr Pro Pro Asp Tyr Tyr Gly Tyr Glu Asp Tyr 
        355                 360                 365             


Tyr Asp Tyr Tyr Gly Tyr Asp Tyr His Asn Tyr Arg Gly Gly Tyr Glu 
    370                 375                 380                 


Asp Pro Tyr Tyr Gly Tyr Glu Asp Phe Gln Val Gly Ala Arg Gly Arg 
385                 390                 395                 400 


Gly Gly Arg Gly Ala Arg Gly Ala Ala Pro Ser Arg Gly Arg Gly Ala 
                405                 410                 415     


Ala Pro Pro Arg Gly Arg Ala Gly Tyr Ser Gln Arg Gly Gly Pro Gly 
            420                 425                 430         


Ser Ala Arg Gly Val Arg Gly Ala Arg Gly Gly Ala Gln Gln Gln Arg 
        435                 440                 445             


Gly Arg Gly Gln Gly Lys Gly Val Glu Ala Gly Pro Asp Leu Leu Gln 
    450                 455                 460                 


<210> 369
<211> 6651
<212> DNA
<213> Homo sapiens

<400> 369
gccggcccgg aaggggctga tgcgaactgg ggccacggca gccatcgcgc tttgcagttc       60

ggtctcctgg tgtacggcca acgccaagta ggggattgcg ttccctccag tcgcagagtt      120

tccctcttgt cgcccaggct ggagtgaagt ggcacgatct cggcttactg caagctccgc      180

ctcccgggtt cacgccattc tcctgcctca gcctcccgag tagctgggac tacagaccct      240

atcagatttg gatatgtcct tcatatttga ttggatttac agtggtttca gcagtgtgct      300

acagttttta ggattatata agaaaactgg taaactggta tttcttggat tggataatgc      360

aggaaaaaca acattgctac acatgctaaa agatgacaga cttggacaac atgtcccaac      420

attacatccc acttccgaag aactgaccat tgctggcatg acgtttacaa cttttgatct      480

gggtggacat gttcaagctc gaagagtgtg gaaaaactac cttcctgcta tcaatggcat      540

tgtatttctg gtggattgtg cagaccacga aaggctgtta gagtcaaaag aagaacttga      600

ttcactaatg acagatgaaa ccattgctaa tgtgcctata ctgattcttg ggaataagat      660

cgacagacct gaagccatca gtgaagagag gttgcgagag atgtttggtt tatatggtca      720

gacaacagga aaggggagta tatctctgaa agaactgaat gcccgaccct tagaagtttt      780

catgtgtagt gtgctcaaaa gacaaggtta cggagaaggc ttccgctgga tggcacagta      840

cattgattaa cacaaactca cattggttcc aggtctcaac gttcaggctt actcagagat      900

ttgattgctc aacatgcata acttgaattc aatagacttt tgctggttat aaaacagatg      960

ttttttagat tattaatatt aaatcaactt aatttgaatg agaattgaaa actgattcaa     1020

gtaagtttga gtatcacaat gttagctttc taattccata aaagtacttg gtttttacag     1080

tttataatct gacatcaccc cagcgccatt tgtaaagagc aactttccag cagtacattt     1140

gaagcacttt ttaacaacat gaaactataa accatattta aaagctcatc atgttaaatt     1200

ttttatgtac ttttctggaa ctagttttta aattttagat tatatgtcca cctatcttaa     1260

gtgtacagtt aataattagc ttattcaatg attgcatgat gccttacagt tttcaataac     1320

tttttttctt atgcaaacgt catgcaataa aacaaactct aatgtttggc atccttgttg     1380

ggcaaatgtt tcatttaaat gtgtcttatc tagctagtat actctgaaaa tttgagtatt     1440

taatattagg catatgaagt ggttgttggg aaaggagatt ccttcagaat atttagaata     1500

gcgtttaagg ctctcaaggc ttaggtattt accatgagat ggttgtggtc agttgcacct     1560

gataccatgt atccctgaat catgtgtatt tttattagta atgcagccac taccattgct     1620

gatggggtct gtgtcctagt ccctgtggga ttggccttct gaagaaaagc acatttatgg     1680

tacacaaggt tgattctcag tttggtaggc tctatagttc catcccagct gtctaattct     1740

gaagtgctcc agtcttattg gtgcccaatg gggtaatctg tgcctcttcc ccaaaagcaa     1800

tgacaggcac cagtgtctcc acatttagat atattcccag tctctgtaca tttaacagta     1860

ctctctgggg caagcaataa gtaggacctt gtgtgcagtt tcattgtaga gacatgtata     1920

tctgaggaat aaaacagctt gttctgtgtc agtctgagat atgtggagat tttgttccta     1980

tcctatagct cttttgtatt ctttggcata ttttatatcc tggtagaaga aaacaagtgc     2040

ttgtttccaa ttttcttttt tcttatttgc tctcaggtag ttcttactcc atacaacaaa     2100

gactttttgt ttgttgggct tttttttttt tttttttttt gctctgtttc attttgtttt     2160

agagacgggg tttcaccatg ttgtccaggc tggtctcaaa ctcctgacct caagtgatct     2220

gcccgccttg gcctcccaaa gttctgggat tataggcgtg agctaccatg cctgacctga     2280

cttttgtttt tagatattat gcttgccatg tgatagggcc tgcaagcctc attgctaggc     2340

ttactaagaa aattttagtt tttcaaaagc attataattt cctaagaaac tgaattcttt     2400

ttttatatgt ttgagattcc catcattagt aatataagat gaaaggtaag tgccaaaaat     2460

gtatttttaa agaccctcaa gtttaagatt tatcctgatt ataagccaag ttttatagta     2520

tatttaacca attccatcaa gaataatttt aatatcaaaa attagtgttt tctgtagcca     2580

ttgtccatgt cagagttaca gtcctttttg tcattgataa tataacctat gaagcagata     2640

aggattgagg aatatgactg gaaggaatta ctatttagct aagctgacaa ggtcgcttct     2700

taagatgaca tttggtttca gtaatctgac tattctgttt tcactttcat cttctttcta     2760

aatgaaaaca aaagtgctcc ctcccttcct ggaaacctca gtaacactat gggaaaagta     2820

gaacatgaca ttgcagccta ttgatttctt cttccagata ggtttaaagt actccttaag     2880

ttctgactaa atagaactaa gccttattaa aaataactgc ctcttgttca tgttatctgt     2940

accttcaggg acctgccttt cttcaagtat ttcctagagt atctattatg atactgaaga     3000

agctaattat ttgtgttgta aatgggtata aatgaaaaaa aaacatactg gtttctctag     3060

ccaggaaaaa tgctttctgg tgtaatatat cttgctccag aaccctcatt ctaattgtaa     3120

cactaggatc aaagaaacaa agtcactttg tggaccacag ctaaactgtg gatattttcc     3180

caaagacata agatttttat ggcccgagcc tctagaaagg aagccatgtt taggagcaac     3240

cagctttcct cccagcttta gggggcagag ttcctgagcc agaggactta ctgtccagct     3300

ttgagaacct ctccagagta tatgcactgg gtactgctct ttttcaagag aaccaaatta     3360

agaggatggc aagaaacagt agaagcacag aggaaagaca actctgcatg tgcctgtgtg     3420

aatgtgtgca tccatggagt atttcccagg taaatactag tactggggac ataggctaat     3480

tgtgtgtccc acactgcaag atgctagggc gtagttaaca ctgtggtata catacaaatc     3540

aggcactgtc caaaagattt tttaaaatct aaagtctgaa atgtaaaaat ataaggtctc     3600

aacccacttt tacactttta aagagatccc atacctgttt cactgactgc cgttaattac     3660

acttttggat cacagctggt taaattgata gatttcagtt tatctcagtg aatttttaga     3720

atggagatta tagcattttt taattggaga acagacattt cctaaagtat atgaaaaaaa     3780

attattcact gttggtttaa accagtatct ttgtatgagt gccaaagata tatgaacaca     3840

gatactgcct gtgcagacct aaattttagt tttgtgtacc tggatccata tacaaatttt     3900

ttgtggttta tagcataaaa gcagaacgtt gtttctttct tagttttcaa ccggctcatc     3960

ttttgttttt gttttttgtt tttttgtttt ttgttttttt tgagatggag tcttgctttg     4020

ttgcccaggc tagagtgcag tggcacaatc tctgcttact gcaacctcca cctccggggt     4080

tcaagtgatt ctcctgcctc agcctcctga gtagctggga ctacaggcgc gcaccaccat     4140

gcccggctaa tttttgtatt tttagtagag atggggtttc actatgttgg ccaggctggt     4200

ctcgaactcc tgacctcgtg atctgcccac ctcagcctcc caaagtgctg ggattacagg     4260

cgtgagccgc catgcccggc caattttcaa ctggcccata ctttatagtg atggaaagcg     4320

cataaactac ttgtaaatca ttaaaatagg gtgataactg tgataatagt gtttcttgca     4380

ttctagaaaa ttattttatt aactacattc aaaacccagc atttcacagg ttccatcatt     4440

agaaacagta tagttctagt taacatgatt ggagagtttc aggggaaagg tttacatttt     4500

ctgaaactgt atttggtatg tgactcaatg tggtatttca gtcttgttag tcacttacat     4560

gactgacgtt tgcaaggatt tattgccaag taaaatttga ccagagtgca ctgagaatag     4620

ctacataagg ggaaatctct caaaattcct tctgttcatt taatttggag catattgttt     4680

aaatcatttt aaacatatgt aaaaagttga agcattaaaa aatcttcaag aaacaatgaa     4740

aaaatagaaa ttagcaaaca taagtttctt aatgcaaaat taatagtgaa taaaatatag     4800

cctacattaa aagccagagg ctttgctata aatataagag tttagaaaaa cagtgtgctt     4860

caattaagga ctaaattatc aaaactgcat gtttgttttt tcttttcttt tctttttttt     4920

ttgagatgaa gtctcactct gttgcccagg ctggagtgca gtggtgcgat cttggctcac     4980

tgcaacctct gcttcccagg ttcaagcgat tctcgtgcct caccatcccg agtagctggg     5040

attacaggtg caccacacca tgcccagtta atttttgtat ttttagtaga gacagggttt     5100

cattatttgg ccaggctggt ctcgagctcc tgatcttaag tgatccactc gcctcggcct     5160

cccaaagtgc tgggattata cacatgagcc actgtgccca gcctaaaact acatgttgaa     5220

gcttccggtc atttccatta ttatccttct tttgaaattc aagttagtgc tttttaacca     5280

aataaaagaa gaaccagctc ttgggatatg tgactctgcc tctgtataaa gtgactggaa     5340

ttttgttaaa accgtgtttc cacttctgaa ccctgttacc attccccctc acaaatcccc     5400

acccaacacc tggattttaa agatcctcca gtgtcaaggg aagccacaga gtctattaaa     5460

gaggcagttc tgaaccaatt aatttttgtc cttataattt agagcattaa atagctaata     5520

tatttaatgg cactaattgt tgttcacggc tttcatcata cttttaaaca gaatccaaag     5580

tattcaaagg aaagtaagcg aagttatcca aagccaactt tgtttcaggt gtgtcccctg     5640

ccccaaatag attttagggc agaaatagaa aactgagttt acacagaact atttttggaa     5700

aagctgcact ggagtagatg gattcttctt cagcatactt ttttgtttgt ttgtttgaga     5760

tggagtcttg ctttgtcacc caggctggag tgcagtggtg tgatctccac tcactgcaac     5820

ctccacctcc cagcttcaag tgattctcct gcctcaacct tccaagtagc ttggattaca     5880

ggcgtgcgcc accacagctg gctaatattt gtattgttag tagagacagg gtttcaccat     5940

gttgtccagg cttgtcgaac ttctgacctc acgtgatcca cctgcctcag cctcccaaag     6000

tgctagatta taggcgtgaa ccactgcgcc cggccagcat gcattttaaa agtggcttag     6060

atttagtttt aaatattttg gggtgaaagg caggaacagt tctgtttttg acatacaggt     6120

tttctttggg attgttttca ttttcaagta tagattcatg tcagaatggc caacttaacg     6180

tgggtttctg tattccctgg tgttgctctt aacctgaact cataatcagt tgccatactg     6240

aggcaagagc actcagggtg aacatagtca agttacttta aaagtgataa aagtgttttt     6300

ccatggtgaa accttcagta tttggctgaa tgtaaagtat gttgaagtgg tatattgatg     6360

gtaagttgtt aatcactaac cttgtttgca cttttgtaca ccactgcttg cactaggatc     6420

ttggtgtgaa ttttcaattg ttttacagtg tatacagatt attaaggata atttatataa     6480

agatgtttct gtttaacttt gtgtgtttta caacaaagag ctataataga tggttaaacg     6540

tttttgaatt gtgtttatat gttagtttga ttatgttcta ttatcttttc acctgccatg     6600

aatttgagtg ttaggaaggg aaaaataaaa tactaatctg gtcttgaaga a              6651


<210> 370
<211> 198
<212> PRT
<213> Homo sapiens

<400> 370
Met Ser Phe Ile Phe Asp Trp Ile Tyr Ser Gly Phe Ser Ser Val Leu 
1               5                   10                  15      


Gln Phe Leu Gly Leu Tyr Lys Lys Thr Gly Lys Leu Val Phe Leu Gly 
            20                  25                  30          


Leu Asp Asn Ala Gly Lys Thr Thr Leu Leu His Met Leu Lys Asp Asp 
        35                  40                  45              


Arg Leu Gly Gln His Val Pro Thr Leu His Pro Thr Ser Glu Glu Leu 
    50                  55                  60                  


Thr Ile Ala Gly Met Thr Phe Thr Thr Phe Asp Leu Gly Gly His Val 
65                  70                  75                  80  


Gln Ala Arg Arg Val Trp Lys Asn Tyr Leu Pro Ala Ile Asn Gly Ile 
                85                  90                  95      


Val Phe Leu Val Asp Cys Ala Asp His Glu Arg Leu Leu Glu Ser Lys 
            100                 105                 110         


Glu Glu Leu Asp Ser Leu Met Thr Asp Glu Thr Ile Ala Asn Val Pro 
        115                 120                 125             


Ile Leu Ile Leu Gly Asn Lys Ile Asp Arg Pro Glu Ala Ile Ser Glu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Met Phe Gly Leu Tyr Gly Gln Thr Thr Gly Lys 
145                 150                 155                 160 


Gly Ser Ile Ser Leu Lys Glu Leu Asn Ala Arg Pro Leu Glu Val Phe 
                165                 170                 175     


Met Cys Ser Val Leu Lys Arg Gln Gly Tyr Gly Glu Gly Phe Arg Trp 
            180                 185                 190         


Met Ala Gln Tyr Ile Asp 
        195             


<210> 371
<211> 3445
<212> DNA
<213> Homo sapiens

<400> 371
attatgtaat tttcccaaaa gccccacctc gcctcagccg ggcgggagag agggaggtct       60

cgcgctttcc ccggggttgc gtcccgcccc gcaggctgcg cgcaggcgct gacgagccgc      120

tcgcattcta cgtaacggac ggcggaggct acgtgaagag aggcgcggcg tgactgagct      180

acggttctgg ctgcgtccta gaggcatccg gggcagtaaa accgctgcga tcgcggaggc      240

ggcggccagg ccgagaggca ggccgggcag gggtgtcgga cgcagggcgc tgggccgggt      300

ttcggcttcg gccacagctt tttttctcaa ggtgcaatga aagccttcca cactttctgt      360

gttgtccttc tggtgtttgg gagtgtctct gaagccaagt ttgatgattt tgaggatgag      420

gaggacatag tagagtatga tgataatgac ttcgctgaat ttgaggatgt catggaagac      480

tctgttactg aatctcctca acgggtcata atcactgaag atgatgaaga tgagaccact      540

gtggagttgg aagggcagga tgaaaaccaa gaaggagatt ttgaagatgc agatacccag      600

gagggagata ctgagagtga accatatgat gatgaagaat ttgaaggtta tgaagacaaa      660

ccagatactt cttctagcaa aaataaagac ccaataacga ttgttgatgt tcctgcacac      720

ctccagaaca gctgggagag ttattatcta gaaattttga tggtgactgg tctgcttgct      780

tatatcatga attacatcat tgggaagaat aaaaacagtc gccttgcaca ggcctggttt      840

aacactcata gggagctttt ggagagcaac tttactttag tgggggatga tggaactaac      900

aaagaagcca caagcacagg aaagttgaac caggagaatg agcacatcta taacctgtgg      960

tgttctggtc gagtgtgctg tgagggcatg cttatccagc tgaggttcct caagagacaa     1020

gacttactga atgtcctggc ccggatgatg aggccagtga gtgatcaagt gcaaataaaa     1080

gtaaccatga atgatgaaga catggatacc tacgtatttg ctgttggcac acggaaagcc     1140

ttggtgcgac tacagaaaga gatgcaggat ttgagtgagt tttgtagtga taaacctaag     1200

tctggagcaa agtatggact gccggactct ttggccatcc tgtcagagat gggagaagtc     1260

acagacggaa tgatggatac aaagatggtt cactttctta cacactatgc tgacaagatt     1320

gaatctgttc atttttcaga ccagttctct ggtccaaaaa ttatgcaaga ggaaggtcag     1380

cctttaaagc tacctgacac taagaggaca ctgttgttta catttaatgt gcctggctca     1440

ggtaacactt acccaaagga tatggaggca ctgctacccc tgatgaacat ggtgatttat     1500

tctattgata aagccaaaaa gttccgactc aacagagaag gcaaacaaaa agcagataag     1560

aaccgtgccc gagtagaaga gaacttcttg aaactgacac atgtgcaaag acaggaagca     1620

gcacagtctc ggcgggagga gaaaaaaaga gcagagaagg agcgaatcat gaatgaggaa     1680

gatcctgaga aacagcgcag gctggaggag gctgcattga ggcgtgagca aaagaagttg     1740

gaaaagaagc aaatgaaaat gaaacaaatc aaagtgaaag ccatgtaaag ccatcccaga     1800

gatttgagtt ctgatgccac ctgtaagctc tgaattcaca ggaaacatga aaaacgccag     1860

tccatttctc aaccttaaat ttcagacagt cttgggcaac tgagaaatcc ttatttcatc     1920

atctactctg tttggggttt ggggttttac agagattgaa gatacctgga aagggctctg     1980

tttcaagaat ttttttttcc agataatcaa attattttga ttattttata aaaggaatga     2040

tctatgaaat ctgtgtaggt tttaaatatt ttaaaaatta taatacaaat catcagtgct     2100

tttagtactt cagtgtttaa agaaataccg tgaaatttat aggtagataa ccagattgtt     2160

gctttttgtt taaaccaagc agttgaaatg gctataaaga ctgactctaa accaagattc     2220

tgcaaataat gattggaatt gcacaataaa cattgcttga tgttttcttg tatgtctaca     2280

ttaaacttga gaaaaagtaa aaattagaac actgtatgta gtaatgaaat ttcagggacc     2340

cagaacataa tgtagtatat gtttttaggt gggagatgct gataacaaaa ttaataggaa     2400

gtctgtaggc attaggatac tgacatgtac atggaaaatt ctagggacag gagcatcatt     2460

ttttccttac ctgataccac gaaccagtga caacgtgaat gctgtatttt aagtggttgt     2520

atgtttattt tcttgagtaa caaatgcatg aaaaattaat gcttcaccta ggtaagatca     2580

ttggtctgtg tgaaatcaca aatgtttttt ccttcttggt tgctgcagcc tggtggatgt     2640

tcatggagaa gctctgttct ctatattatg gctgtgtgcc gttgcttctc cctctgcttt     2700

tatcttttcc acagttgagg ctgggtatgt tctttcaaag aaatggccat gaatatgtgt     2760

aagtatactt ttgaaaatga gctttcctaa actattgaga gttctttcca cctcttgcgg     2820

aaccaactct tggaggagag gcccatgtat ctgcacgagc acttagcttg ttcagatctc     2880

tgcattttat aaatgcttct taccaagaaa gcatttttag gtcattgctt gtaccaggta     2940

atttttgccg gggatgggta agggttgggt tttctggtgg gagtggggtg gtgggtattt     3000

tttgttgatg ctttagtgca ggcctgttct gaggcaataa caagttgctg tgaaaacagc     3060

atgtgctgct gcctttgtaa ctgcatggaa acttttcaca tgggtttttc tccaagttaa     3120

tacagaaata tgtaaactga gagatgcaaa tgtaatattt ttaacagttc atgaagttgt     3180

tattaaaata actaacataa aacttaatta ctttaatatt atataattat agtagtggcc     3240

ttgttttaca aacctttaaa ttacatttta gaaatcaaag ttgatagtct tagttatctt     3300

ttgagtaaga aaagctttcc taaagtccca tacatttgga ccatggcagc taattttgta     3360

acttaagcat tcatatgaac tacctatgga catctattaa agtgattgac aaaatctcaa     3420

aaaaaaaaaa aaaaaaaaaa aaaaa                                           3445


<210> 372
<211> 483
<212> PRT
<213> Homo sapiens

<400> 372
Met Lys Ala Phe His Thr Phe Cys Val Val Leu Leu Val Phe Gly Ser 
1               5                   10                  15      


Val Ser Glu Ala Lys Phe Asp Asp Phe Glu Asp Glu Glu Asp Ile Val 
            20                  25                  30          


Glu Tyr Asp Asp Asn Asp Phe Ala Glu Phe Glu Asp Val Met Glu Asp 
        35                  40                  45              


Ser Val Thr Glu Ser Pro Gln Arg Val Ile Ile Thr Glu Asp Asp Glu 
    50                  55                  60                  


Asp Glu Thr Thr Val Glu Leu Glu Gly Gln Asp Glu Asn Gln Glu Gly 
65                  70                  75                  80  


Asp Phe Glu Asp Ala Asp Thr Gln Glu Gly Asp Thr Glu Ser Glu Pro 
                85                  90                  95      


Tyr Asp Asp Glu Glu Phe Glu Gly Tyr Glu Asp Lys Pro Asp Thr Ser 
            100                 105                 110         


Ser Ser Lys Asn Lys Asp Pro Ile Thr Ile Val Asp Val Pro Ala His 
        115                 120                 125             


Leu Gln Asn Ser Trp Glu Ser Tyr Tyr Leu Glu Ile Leu Met Val Thr 
    130                 135                 140                 


Gly Leu Leu Ala Tyr Ile Met Asn Tyr Ile Ile Gly Lys Asn Lys Asn 
145                 150                 155                 160 


Ser Arg Leu Ala Gln Ala Trp Phe Asn Thr His Arg Glu Leu Leu Glu 
                165                 170                 175     


Ser Asn Phe Thr Leu Val Gly Asp Asp Gly Thr Asn Lys Glu Ala Thr 
            180                 185                 190         


Ser Thr Gly Lys Leu Asn Gln Glu Asn Glu His Ile Tyr Asn Leu Trp 
        195                 200                 205             


Cys Ser Gly Arg Val Cys Cys Glu Gly Met Leu Ile Gln Leu Arg Phe 
    210                 215                 220                 


Leu Lys Arg Gln Asp Leu Leu Asn Val Leu Ala Arg Met Met Arg Pro 
225                 230                 235                 240 


Val Ser Asp Gln Val Gln Ile Lys Val Thr Met Asn Asp Glu Asp Met 
                245                 250                 255     


Asp Thr Tyr Val Phe Ala Val Gly Thr Arg Lys Ala Leu Val Arg Leu 
            260                 265                 270         


Gln Lys Glu Met Gln Asp Leu Ser Glu Phe Cys Ser Asp Lys Pro Lys 
        275                 280                 285             


Ser Gly Ala Lys Tyr Gly Leu Pro Asp Ser Leu Ala Ile Leu Ser Glu 
    290                 295                 300                 


Met Gly Glu Val Thr Asp Gly Met Met Asp Thr Lys Met Val His Phe 
305                 310                 315                 320 


Leu Thr His Tyr Ala Asp Lys Ile Glu Ser Val His Phe Ser Asp Gln 
                325                 330                 335     


Phe Ser Gly Pro Lys Ile Met Gln Glu Glu Gly Gln Pro Leu Lys Leu 
            340                 345                 350         


Pro Asp Thr Lys Arg Thr Leu Leu Phe Thr Phe Asn Val Pro Gly Ser 
        355                 360                 365             


Gly Asn Thr Tyr Pro Lys Asp Met Glu Ala Leu Leu Pro Leu Met Asn 
    370                 375                 380                 


Met Val Ile Tyr Ser Ile Asp Lys Ala Lys Lys Phe Arg Leu Asn Arg 
385                 390                 395                 400 


Glu Gly Lys Gln Lys Ala Asp Lys Asn Arg Ala Arg Val Glu Glu Asn 
                405                 410                 415     


Phe Leu Lys Leu Thr His Val Gln Arg Gln Glu Ala Ala Gln Ser Arg 
            420                 425                 430         


Arg Glu Glu Lys Lys Arg Ala Glu Lys Glu Arg Ile Met Asn Glu Glu 
        435                 440                 445             


Asp Pro Glu Lys Gln Arg Arg Leu Glu Glu Ala Ala Leu Arg Arg Glu 
    450                 455                 460                 


Gln Lys Lys Leu Glu Lys Lys Gln Met Lys Met Lys Gln Ile Lys Val 
465                 470                 475                 480 


Lys Ala Met 
            


<210> 373
<211> 1814
<212> DNA
<213> Homo sapiens

<400> 373
ctgagcgggt gcgcgggcaa cttccggtgt gggtgacgag tggtggccga agcaggggga       60

cagcaaggga cgctcaggcg gggaccatgg cggacggcgg ctcggagcgg gctgacgggc      120

gcatcgtcaa gatggaggtg gactacagcg ccacggtgga tcagcgccta cccgagtgtg      180

cgaagctagc caaggaagga agacttcaag aagtcattga aacccttctc tctctggaaa      240

agcagactcg tactgcttcc gatatggtat cgacatcccg tatcttagtt gcagtagtga      300

agatgtgcta tgaggctaaa gaatgggatt tacttaatga aaatattatg cttttgtcca      360

aaaggcggag tcagttaaaa caagctgttg ccaaaatggt tcaacagtgc tgtacttatg      420

ttgaggaaat cacagacctt cctatcaaac ttcgattaat tgatactcta cgaatggtta      480

ccgaaggcaa gatttatgtt gaaattgagc gtgcgcgact gactaaaaca ttagcaacta      540

taaaagaaca aaatggtgat gtgaaagagg cagcctccat tttacaggag ttacaggtgg      600

aaacctacgg gtcaatggaa aagaaagagc gagtggaatt tattttggag caaatgaggc      660

tctgcctagc tgtgaaggat tacattcgaa cacaaatcat cagcaagaaa attaacacca      720

aatttttcca ggaagaaaat acagagaaat taaagttgaa gtactataat ttaatgattc      780

agctggatca acatgaggga tcctatttgt ctatttgtaa gcactacaga gcaatatatg      840

atactccctg tatacaggca gaaagtgaaa aatggcagca ggctctgaag agtgttgtac      900

tctatgttat cctggctcct tttgacaatg aacagtcaga tttggttcac cgaataagtg      960

gtgacaagaa gttagaagaa attcccaaat acaaggatct tttaaagctt tttaccacaa     1020

tggagttgat gcgttggtcc acacttgttg aggactatgg aatggaatta agaaaaggtt     1080

cccttgagag tcctgcaacg gatgtttttg gttctacaga ggaaggtgaa aaaaggtgga     1140

aagacttgaa gaacagagtt gttgaacata atattagaat aatggccaag tattatactc     1200

ggataacaat gaaaaggatg gcacagcttc tggatctatc tgttgatgag tccgaagcct     1260

ttctctcaaa tctagtagtt aacaagacca tctttgctaa agtagacaga ttagcaggaa     1320

ttatcaactt ccagagaccc aaggatccaa ataatttatt aaatgactgg tctcagaaac     1380

tgaactcatt aatgtctctg gttaacaaaa ctacgcatct catagccaaa gaggagatga     1440

tacataatct acaataaggg tcttagtgct ttagaaaaaa gttaaaattg gaagtcatta     1500

aaaaaagact gttataatgg tgtatatgtt ggggtttttt ttctaagctt ctttgtctta     1560

aattttaaaa tagtgaatat gtttgagact ccctttgacc tttcagttcc ccaagttcat     1620

tgttaacttt gcatttgcaa ttggtgcaaa aatacagatt tctgtcgtct gaatacacaa     1680

aaagttgtgt cataacttac ccagatatgt ttttctatca tttgaaacct ttttagctac     1740

tgtttgtttt cattcaacta acaaacatat tccaataata aaagcagtat atacataaaa     1800

aaaaaaaaaa aaaa                                                       1814


<210> 374
<211> 456
<212> PRT
<213> Homo sapiens

<400> 374
Met Ala Asp Gly Gly Ser Glu Arg Ala Asp Gly Arg Ile Val Lys Met 
1               5                   10                  15      


Glu Val Asp Tyr Ser Ala Thr Val Asp Gln Arg Leu Pro Glu Cys Ala 
            20                  25                  30          


Lys Leu Ala Lys Glu Gly Arg Leu Gln Glu Val Ile Glu Thr Leu Leu 
        35                  40                  45              


Ser Leu Glu Lys Gln Thr Arg Thr Ala Ser Asp Met Val Ser Thr Ser 
    50                  55                  60                  


Arg Ile Leu Val Ala Val Val Lys Met Cys Tyr Glu Ala Lys Glu Trp 
65                  70                  75                  80  


Asp Leu Leu Asn Glu Asn Ile Met Leu Leu Ser Lys Arg Arg Ser Gln 
                85                  90                  95      


Leu Lys Gln Ala Val Ala Lys Met Val Gln Gln Cys Cys Thr Tyr Val 
            100                 105                 110         


Glu Glu Ile Thr Asp Leu Pro Ile Lys Leu Arg Leu Ile Asp Thr Leu 
        115                 120                 125             


Arg Met Val Thr Glu Gly Lys Ile Tyr Val Glu Ile Glu Arg Ala Arg 
    130                 135                 140                 


Leu Thr Lys Thr Leu Ala Thr Ile Lys Glu Gln Asn Gly Asp Val Lys 
145                 150                 155                 160 


Glu Ala Ala Ser Ile Leu Gln Glu Leu Gln Val Glu Thr Tyr Gly Ser 
                165                 170                 175     


Met Glu Lys Lys Glu Arg Val Glu Phe Ile Leu Glu Gln Met Arg Leu 
            180                 185                 190         


Cys Leu Ala Val Lys Asp Tyr Ile Arg Thr Gln Ile Ile Ser Lys Lys 
        195                 200                 205             


Ile Asn Thr Lys Phe Phe Gln Glu Glu Asn Thr Glu Lys Leu Lys Leu 
    210                 215                 220                 


Lys Tyr Tyr Asn Leu Met Ile Gln Leu Asp Gln His Glu Gly Ser Tyr 
225                 230                 235                 240 


Leu Ser Ile Cys Lys His Tyr Arg Ala Ile Tyr Asp Thr Pro Cys Ile 
                245                 250                 255     


Gln Ala Glu Ser Glu Lys Trp Gln Gln Ala Leu Lys Ser Val Val Leu 
            260                 265                 270         


Tyr Val Ile Leu Ala Pro Phe Asp Asn Glu Gln Ser Asp Leu Val His 
        275                 280                 285             


Arg Ile Ser Gly Asp Lys Lys Leu Glu Glu Ile Pro Lys Tyr Lys Asp 
    290                 295                 300                 


Leu Leu Lys Leu Phe Thr Thr Met Glu Leu Met Arg Trp Ser Thr Leu 
305                 310                 315                 320 


Val Glu Asp Tyr Gly Met Glu Leu Arg Lys Gly Ser Leu Glu Ser Pro 
                325                 330                 335     


Ala Thr Asp Val Phe Gly Ser Thr Glu Glu Gly Glu Lys Arg Trp Lys 
            340                 345                 350         


Asp Leu Lys Asn Arg Val Val Glu His Asn Ile Arg Ile Met Ala Lys 
        355                 360                 365             


Tyr Tyr Thr Arg Ile Thr Met Lys Arg Met Ala Gln Leu Leu Asp Leu 
    370                 375                 380                 


Ser Val Asp Glu Ser Glu Ala Phe Leu Ser Asn Leu Val Val Asn Lys 
385                 390                 395                 400 


Thr Ile Phe Ala Lys Val Asp Arg Leu Ala Gly Ile Ile Asn Phe Gln 
                405                 410                 415     


Arg Pro Lys Asp Pro Asn Asn Leu Leu Asn Asp Trp Ser Gln Lys Leu 
            420                 425                 430         


Asn Ser Leu Met Ser Leu Val Asn Lys Thr Thr His Leu Ile Ala Lys 
        435                 440                 445             


Glu Glu Met Ile His Asn Leu Gln 
    450                 455     


<210> 375
<211> 2116
<212> DNA
<213> Homo sapiens

<400> 375
actcccgggc cgccgggggc actagggggg gtggggtttc cttccgcatc tccacggttc       60

caactccaac ctagactcaa actggacgcc ggccggagac tccgctccgg cagcaaaccc      120

cacgtggtgc acctctgagc ctccgcccct ctcccgaggg aaccgcaact ctacttctcg      180

cgagaattgc ttctatggct ccatcctgct ttccggctgt cgccctcatg cgataggctc      240

tcagcgttac ttgactcttc tcgcgataat tttttttaaa aatctcccaa ggaaagttga      300

aggaagagta caaaattttc atctcgcgag acttgtgagc ggccatcttg gtcctgccct      360

gacagattct cctatcgggg tcacagggac gctaagattg ctacctggac tttcgttgac      420

catgctgtcc cgggtggtac tttccgccgc cgccacagcg gccccctctc tgaagaatgc      480

agccttccta ggtccagggg tattgcaggc aacaaggacc tttcatacag ggcagccaca      540

ccttgtccct gtaccacctc ttcctgaata cggaggaaaa gttcgttatg gactgatccc      600

tgaggaattc ttccagtttc tttatcctaa aactggtgta acaggaccct atgtactcgg      660

aactgggctt atcttgtacg ctttatccaa agaaatatat gtgattagcg cagagacctt      720

cactgcccta tcagtactag gtgtaatggt ctatggaatt aaaaaatatg gtccctttgt      780

tgcagacttt gctgataaac tcaatgagca aaaacttgcc caactagaag aggcgaagca      840

ggcttccatc caacacatcc agaatgcaat tgatacggag aagtcacaac aggcactggt      900

tcagaagcgc cattaccttt ttgatgtgca aaggaataac attgctatgg ctttggaagt      960

tacttaccgg gaacgactgt atagagtata taaggaagta aagaatcgcc tggactatca     1020

tatatctgtg cagaacatga tgcgtcgaaa ggaacaagaa cacatgataa attgggtgga     1080

gaagcacgtg gtgcaaagca tctccacaca gcaggaaaag gagacaattg ccaagtgcat     1140

tgcggaccta aagctgctgg caaagaaggc tcaagcacag ccagttatgt aaatgtatct     1200

atcccaattg agacagctag aaacagttga ctgactaaat ggaaactagt ctatttgaca     1260

aagtctttct gtgttggtgt ctactgaagt tatagtttac ccttcctaaa aatgaaaagt     1320

ttgtttcata tagtgagaga acgaaatctc tatcggccag tcagatgttt ctcatccttc     1380

ttgctctgcc tttgagttgt tccgtgatca cttctgaata agcagtttgc ctttataaaa     1440

acttgctgcc tgactaaaga ttaacaggtt atagtttaaa tttgtaatta attctaccat     1500

cttgcaataa agtgacaatt gaatgaaaca gggtttttca agttgtataa ttctctgaaa     1560

tactcagctt ttgtcatatg ggtaaaaatt aaagatgtca ttgaactact gtcttgttta     1620

tgagaccatt cagtggtgaa ctgtttctgg ctgataggtt atgagatatg taaagctttc     1680

tagtactctt aaaataacta aatggagtat tatatatcaa ttcatatcat tgactttatt     1740

attttagtag tatgcctata gaaaatatta tggactcaga gtgtcataaa atcactctta     1800

agaatccatg cagcaggcca ggcacagtgg ctcacacctg taatgcctgc actttggaag     1860

gccgagacag gcggatcact tgaggtcagg agtttgaaac cagccaggcc aacacagtga     1920

aaccctgtct ctactaaaaa tacaaaaggt tagccgggca tggtggcagg cgcctgtaat     1980

cccagctact caggaggctg aggcaggaga attgcttgaa cgcaggaggc aaaggttgca     2040

gtgagctgag atcacgccac tgcactccag cctgggcaac agacctcgac tccatctaga     2100

aaaaaaaaaa aaaaaa                                                     2116


<210> 376
<211> 256
<212> PRT
<213> Homo sapiens

<400> 376
Met Leu Ser Arg Val Val Leu Ser Ala Ala Ala Thr Ala Ala Pro Ser 
1               5                   10                  15      


Leu Lys Asn Ala Ala Phe Leu Gly Pro Gly Val Leu Gln Ala Thr Arg 
            20                  25                  30          


Thr Phe His Thr Gly Gln Pro His Leu Val Pro Val Pro Pro Leu Pro 
        35                  40                  45              


Glu Tyr Gly Gly Lys Val Arg Tyr Gly Leu Ile Pro Glu Glu Phe Phe 
    50                  55                  60                  


Gln Phe Leu Tyr Pro Lys Thr Gly Val Thr Gly Pro Tyr Val Leu Gly 
65                  70                  75                  80  


Thr Gly Leu Ile Leu Tyr Ala Leu Ser Lys Glu Ile Tyr Val Ile Ser 
                85                  90                  95      


Ala Glu Thr Phe Thr Ala Leu Ser Val Leu Gly Val Met Val Tyr Gly 
            100                 105                 110         


Ile Lys Lys Tyr Gly Pro Phe Val Ala Asp Phe Ala Asp Lys Leu Asn 
        115                 120                 125             


Glu Gln Lys Leu Ala Gln Leu Glu Glu Ala Lys Gln Ala Ser Ile Gln 
    130                 135                 140                 


His Ile Gln Asn Ala Ile Asp Thr Glu Lys Ser Gln Gln Ala Leu Val 
145                 150                 155                 160 


Gln Lys Arg His Tyr Leu Phe Asp Val Gln Arg Asn Asn Ile Ala Met 
                165                 170                 175     


Ala Leu Glu Val Thr Tyr Arg Glu Arg Leu Tyr Arg Val Tyr Lys Glu 
            180                 185                 190         


Val Lys Asn Arg Leu Asp Tyr His Ile Ser Val Gln Asn Met Met Arg 
        195                 200                 205             


Arg Lys Glu Gln Glu His Met Ile Asn Trp Val Glu Lys His Val Val 
    210                 215                 220                 


Gln Ser Ile Ser Thr Gln Gln Glu Lys Glu Thr Ile Ala Lys Cys Ile 
225                 230                 235                 240 


Ala Asp Leu Lys Leu Leu Ala Lys Lys Ala Gln Ala Gln Pro Val Met 
                245                 250                 255     


<210> 377
<211> 2956
<212> DNA
<213> Homo sapiens

<400> 377
gacagggccg cggacgcccg ggcagccacg gcggcggggc cgcggcgggc gccggctcag       60

cccgcccctt tctcccgccg cctccccgcc ccgccccgcg ccgcgccggc cgctgtcagc      120

tccctcagcg tccggccgag gcgcggtgta tgctgagccg ctgccgcagc gggctgctcc      180

acgtcctggg ccttagcttc ctgctgcaga cccgccggcc gattctcctc tgctctccac      240

gtctcatgaa gccgctggtc gtgttcgtcc tcggcggccc cggcgccggc aaggggaccc      300

agtgcgcccg catcgtcgag aaatatggct acacacacct ttctgcagga gagctgcttc      360

gtgatgaaag gaagaaccca gattcacagt atggtgaact tattgaaaag tacattaaag      420

aaggaaagat tgtaccagtt gagataacca tcagtttatt aaagagggaa atggatcaga      480

caatggctgc caatgctcag aagaataaat tcttgattga tgggtttcca agaaatcaag      540

acaaccttca aggatggaac aagaccatgg atgggaaggc agatgtatct ttcgttctct      600

tttttgactg taataatgag atttgtattg aacgatgtct tgagagggga aagagtagtg      660

gtaggagtga tgacaacaga gagagcttgg aaaagagaat tcagacctac cttcagtcaa      720

caaagccaat tattgactta tatgaagaaa tggggaaagt caagaaaata gatgcttcta      780

aatctgttga tgaagttttt gatgaagttg tgcagatttt tgacaaggaa ggctaattct      840

aaacctgaag gcatccttga aatcatgctt gaatattgct ttgatagctg ctatcatgac      900

ccctttttaa ggcaattcta atctttcata actacatctc aattagtggc tggaaagtac      960

atggtaaaac aaagtaaatt tttttatgtt cttttttttg gtcacaggag tagacagtga     1020

attcaggttt aacttcacct tagttatggt gctcaccaaa cgaagggtat cagctatttt     1080

ttttaaaatt caaaaagaat atccctttta tagtttgtgc cttctgtgag caaaactttt     1140

tagtacgcgt atatatccct ctagtaatca caacatttta ggatttaggg atacccgctt     1200

cctctttttc ttgcaagttt taaatttcca accttaagtg aatttgtgga ccaaatttca     1260

aaggaacttt ttgtgtagtc agttcttgca caatgtgttt ggtaaacaaa ctcaaaatgg     1320

attcttagga gcattttagt gtttattaaa taactgacca tttgctgtag aaagatgaga     1380

aaacttaagc tttgttttac tacaacttgt acaaagttgt atgacagggc atattctttg     1440

cttccaagat ttgggttggg ggcactaggg gttcagagcc tggcagaatt gtcagcttta     1500

gtctgacata atctaagggt atggggcaag gatcacatct aatgcttgtg ttccttatac     1560

tctattatat agtgttattc atgattcagc tgatcttaac aaaattcgta gcagtggaac     1620

cttgaaatgc atgtggctag atttatgcta aaatgattct cagttagcat tttagtaaca     1680

cttcaaaggt ttttttttgt ttgttttcta gacttaataa aagcttagga ttaattagaa     1740

gaagcaatct agttaaattt cccatttgta ttttattttc ttgaatactt ttttcatagt     1800

tatttgttta aaaagattta aaaatcattg cactttggtc agaaaaataa taaatatatc     1860

ttataaatgt ttgattccct tccttgctat ttttattcag tagatttttg tttggcatca     1920

tgttgaagca ccgaaagata aatgattttt aaaaggctat agagtccaaa ggaatattct     1980

tttacaccaa ttcttccttt aaaaatctct gaggaatttg ttttcgcctt actttttttt     2040

cttctgtcac aatgctaagt ggtatccgag gttcttaata tgagatttaa aatcttaaaa     2100

tgtttcttat tttcagcact tacatcattt ggtacacagg gtcaaatagg gcaaataatt     2160

ttgtctttgt ataatagatt tgatatttaa agtcactgga aataggacaa gttaatggat     2220

gtttttatat tttaatagaa tcatttattt ctatgtgtta tgaaattcac ttaatgataa     2280

atttttcaac atacttgcca ttagaaaaca aagtattgct aagtactata acatattggc     2340

cactaaaatt catattgaga ttatcttggt ttcttggaag agataggaat gagttcttat     2400

ctagtgttgc aggccagcaa atacagaggt ggtttaatca aacagctcta gtatgaagca     2460

agagtaaaga ctaaggtttc gagagcattc ctactcacat aagtgaagaa atctgtcaga     2520

taggaatcta aatatttata gtgagattgt gaaagcaacc ttaaagtttt gaagaagact     2580

gatgagacta ggtgctttgc ttcctttcat caggtatctt tctgtggcat ttgagaacag     2640

aaaccaagaa acatggtaat tactaaatta tgaggctttg ctttttgttt gcttttaagt     2700

agaaaaacat gttggcaaca ttgagttttg gagttgattg agataatatg acttaactag     2760

ttttgtcatt ccatttgtta aagatacagt caccaagaat gttttgagtt ttttgaaaga     2820

ccccaattta agccttgctt atttttaaat tatttccatt cagtgatgtt ggatgtatat     2880

cagttattta gtaaataatc tcaataaatt ttgtgctgtg gcctttgcta aaaaaaaaaa     2940

aaaaaaaaaa aaaaaa                                                     2956


<210> 378
<211> 228
<212> PRT
<213> Homo sapiens

<400> 378
Met Leu Ser Arg Cys Arg Ser Gly Leu Leu His Val Leu Gly Leu Ser 
1               5                   10                  15      


Phe Leu Leu Gln Thr Arg Arg Pro Ile Leu Leu Cys Ser Pro Arg Leu 
            20                  25                  30          


Met Lys Pro Leu Val Val Phe Val Leu Gly Gly Pro Gly Ala Gly Lys 
        35                  40                  45              


Gly Thr Gln Cys Ala Arg Ile Val Glu Lys Tyr Gly Tyr Thr His Leu 
    50                  55                  60                  


Ser Ala Gly Glu Leu Leu Arg Asp Glu Arg Lys Asn Pro Asp Ser Gln 
65                  70                  75                  80  


Tyr Gly Glu Leu Ile Glu Lys Tyr Ile Lys Glu Gly Lys Ile Val Pro 
                85                  90                  95      


Val Glu Ile Thr Ile Ser Leu Leu Lys Arg Glu Met Asp Gln Thr Met 
            100                 105                 110         


Ala Ala Asn Ala Gln Lys Asn Lys Phe Leu Ile Asp Gly Phe Pro Arg 
        115                 120                 125             


Asn Gln Asp Asn Leu Gln Gly Trp Asn Lys Thr Met Asp Gly Lys Ala 
    130                 135                 140                 


Asp Val Ser Phe Val Leu Phe Phe Asp Cys Asn Asn Glu Ile Cys Ile 
145                 150                 155                 160 


Glu Arg Cys Leu Glu Arg Gly Lys Ser Ser Gly Arg Ser Asp Asp Asn 
                165                 170                 175     


Arg Glu Ser Leu Glu Lys Arg Ile Gln Thr Tyr Leu Gln Ser Thr Lys 
            180                 185                 190         


Pro Ile Ile Asp Leu Tyr Glu Glu Met Gly Lys Val Lys Lys Ile Asp 
        195                 200                 205             


Ala Ser Lys Ser Val Asp Glu Val Phe Asp Glu Val Val Gln Ile Phe 
    210                 215                 220                 


Asp Lys Glu Gly 
225             


<210> 379
<211> 590
<212> DNA
<213> Homo sapiens

<400> 379
tgggcgtggc ttgaatgact tcagtggcct cctcctggga gggagctgaa gccgctcgca       60

agactcccgt agtccccacc tctctcagct tccggctggt agtagttccg cttcctgtcc      120

gactgtggtg tctttgctga gggtcacatt gagctgcagg ttgaatccgg ggtgccttta      180

ggattcagca ccatggcgga agacatggag accaaaatca agaactacaa gaccgcccct      240

tttgacagcc gcttccccaa ccagaaccag actagaaact gctggcagaa ctacctggac      300

ttccaccgct gtcagaaggc aatgaccgct aaaggaggcg atatctctgt gtgcgaatgg      360

taccagcgtg tgtaccagtc cctctgcccc acatcctggg tcacagactg ggatgagcaa      420

cgggctgaag gcacgtttcc cgggaagatc tgaactggct gcatctccct ttcctctgtc      480

ctccatcctt ctcccaggat ggtgaagggg gacctggtac ccagtgatcc ccaccccagg      540

atcctaaatc atgacttacc tgctaataaa aactcattgg aaaagtgaga                 590


<210> 380
<211> 86
<212> PRT
<213> Homo sapiens

<400> 380
Met Ala Glu Asp Met Glu Thr Lys Ile Lys Asn Tyr Lys Thr Ala Pro 
1               5                   10                  15      


Phe Asp Ser Arg Phe Pro Asn Gln Asn Gln Thr Arg Asn Cys Trp Gln 
            20                  25                  30          


Asn Tyr Leu Asp Phe His Arg Cys Gln Lys Ala Met Thr Ala Lys Gly 
        35                  40                  45              


Gly Asp Ile Ser Val Cys Glu Trp Tyr Gln Arg Val Tyr Gln Ser Leu 
    50                  55                  60                  


Cys Pro Thr Ser Trp Val Thr Asp Trp Asp Glu Gln Arg Ala Glu Gly 
65                  70                  75                  80  


Thr Phe Pro Gly Lys Ile 
                85      


<210> 381
<211> 2254
<212> DNA
<213> Homo sapiens

<400> 381
agagtgcacc cgaatccacg ggctcggagg cagcagccat ctctcggcca tagggcaggc       60

cagctggcgc cgggggctat tttgggcggc gggcaatgat ggtgaccgca aggcgacctt      120

gtaaggcatt tcccccctga ctcccttccc cgagcctctg cccgggggtc ctagcgccgc      180

tttctcagcc atcccgccta caacttagcc gtccacaaca ggatcatctg atcgcgtgcg      240

cccgggctac gatctgcgag gcccgcggac cttgacccgg cattgaccgc caccgccccc      300

caggtccgta gggaccaaag aaggggcggg aggaagactg tcacgtggcg ccggagttca      360

cgtgactcgt acacatgact tccagtcccc gggcgcctcc tggagagcaa ggacgcgggg      420

gagcagagat gatccgagcc gcgccgccgc cgctgttcct gctgctgctg ctgctgctgc      480

tgctagtgtc ctgggcgtcc cgaggcgagg cagcccccga ccaggacgag atccagcgcc      540

tccccgggct ggccaagcag ccgtctttcc gccagtactc cggctacctc aaaggctccg      600

gctccaagca cctccactac tggtttgtgg agtcccagaa ggatcccgag aacagccctg      660

tggtgctttg gctcaatggg ggtcccggct gcagctcact agatgggctc ctcacagagc      720

atggcccctt cctggtccag ccagatggtg tcaccctgga gtacaacccc tattcttgga      780

atctgattgc caatgtgtta tacctggagt ccccagctgg ggtgggcttc tcctactccg      840

atgacaagtt ttatgcaact aatgacactg aggtcgccca gagcaatttt gaggcccttc      900

aagatttctt ccgcctcttt ccggagtaca agaacaacaa acttttcctg accggggaga      960

gctatgctgg catctacatc cccaccctgg ccgtgctggt catgcaggat cccagcatga     1020

accttcaggg gctggctgtg ggcaatggac tctcctccta tgagcagaat gacaactccc     1080

tggtctactt tgcctactac catggccttc tggggaacag gctttggtct tctctccaga     1140

cccactgctg ctctcaaaac aagtgtaact tctatgacaa caaagacctg gaatgcgtga     1200

ccaatcttca ggaagtggcc cgcatcgtgg gcaactctgg cctcaacatc tacaatctct     1260

atgccccgtg tgctggaggg gtgcccagcc attttaggta tgagaaggac actgttgtgg     1320

tccaggattt gggcaacatc ttcactcgcc tgccactcaa gcggatgtgg catcaggcac     1380

tgctgcgctc aggggataaa gtgcgcatgg accccccctg caccaacaca acagctgctt     1440

ccacctacct caacaacccg tacgtgcgga aggccctcaa catcccggag cagctgccac     1500

aatgggacat gtgcaacttt ctggtaaact tacagtaccg ccgtctctac cgaagcatga     1560

actcccagta tctgaagctg cttagctcac agaaatacca gatcctatta tataatggag     1620

atgtagacat ggcctgcaat ttcatggggg atgagtggtt tgtggattcc ctcaaccaga     1680

agatggaggt gcagcgccgg ccctggttag tgaagtacgg ggacagcggg gagcagattg     1740

ccggcttcgt gaaggagttc tcccacatcg cctttctcac gatcaagggc gccggccaca     1800

tggttcccac cgacaagccc ctcgctgcct tcaccatgtt ctcccgcttc ctgaacaagc     1860

agccatactg atgaccacag caaccagctc cacggcctga tgcagcccct cccagcctct     1920

cccgctagga gagtcctctt ctaagcaaag tgcccctgca ggccgggttc tgccgccagg     1980

actgccccct tcccagagcc ctgtacatcc cagactgggc ccagggtctc ccatagacag     2040

cctgggggca agttagcact ttattcccgc agcagttcct gaatggggtg gcctggcccc     2100

ttctctgctt aaagaatgcc ctttatgatg cactgattcc atcccaggaa cccaacagag     2160

ctcaggacag cccacaggga ggtggtggac ggactgtaat tgatagattg attatggaat     2220

taaattgggt acagcttcaa aaaaaaaaaa aaaa                                 2254


<210> 382
<211> 498
<212> PRT
<213> Homo sapiens

<400> 382
Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu 
        115                 120                 125             


Glu Tyr Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu 
    130                 135                 140                 


Glu Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr 
145                 150                 155                 160 


Ala Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln 
                165                 170                 175     


Asp Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu 
            180                 185                 190         


Thr Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu 
        195                 200                 205             


Val Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn 
    210                 215                 220                 


Gly Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala 
225                 230                 235                 240 


Tyr Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr 
                245                 250                 255     


His Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu 
            260                 265                 270         


Glu Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser 
        275                 280                 285             


Gly Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro 
    290                 295                 300                 


Ser His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly 
305                 310                 315                 320 


Asn Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu 
                325                 330                 335     


Leu Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr 
            340                 345                 350         


Thr Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu 
        355                 360                 365             


Asn Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val 
    370                 375                 380                 


Asn Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu 
385                 390                 395                 400 


Lys Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp 
                405                 410                 415     


Val Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser 
            420                 425                 430         


Leu Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr 
        435                 440                 445             


Gly Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His 
    450                 455                 460                 


Ile Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp 
465                 470                 475                 480 


Lys Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln 
                485                 490                 495     


Pro Tyr 
        


<210> 383
<211> 1847
<212> DNA
<213> Homo sapiens

<400> 383
cagaaggccg tggggagtgg gggccagtgc ctgcagcctg ccctgcctct ctcacaggcc       60

cttagagcat cgccaggtgc agagctccac agctctcttt cccaaggagt aatcagaggg      120

tgagaacgtg gagcctggtg gacaggtgaa agcactggga tctttctgcc cagaaagggg      180

aaagttgcac atttatatcc tagagggaag cgacagcagt gcttctccct gtgctgaggt      240

acaggagcca tgtggctaga aatcctcctc acttcagtgc tgggctttgc catctactgg      300

ttcatctccc gggacaaaga ggaaactttg ccacttgaag atgggtggtg ggggccaggc      360

acgaggtccg cagccaggga ggacgacagc atccgccctt tcaaggtgga aacgtcagat      420

gaggagatcc acgacttaca ccagaggatc gataagttcc gtttcacccc acctttggag      480

gacagctgct tccactatgg cttcaactcc aactacctga agaaagtcat ctcctactgg      540

cggaatgaat ttgactggaa gaagcaggtg gagattctca acagataccc tcacttcaag      600

actaagattg aagggctgga catccacttc atccacgtga agccccccca gctgcccgca      660

ggccataccc cgaagccctt gctgatggtg cacggctggc ccggctcttt ctacgagttt      720

tataagatca tcccactcct gactgacccc aagaaccatg gcctgagcga tgagcacgtt      780

tttgaagtca tctgcccttc catccctggc tatggcttct cagaggcatc ctccaagaag      840

gggttcaact cggtggccac cgccaggatc ttttacaagc tgatgctgcg gctgggcttc      900

caggaattct acattcaagg aggggactgg gggtccctga tctgcactaa tatggcccag      960

ctggtgccca gccacgtgaa aggcctgcac ttgaacatgg ctttggtttt aagcaacttc     1020

tctaccctga ccctcctcct gggacagcgt ttcgggaggt ttcttggcct cactgagagg     1080

gatgtggagc tgctgtaccc cgtcaaggag aaggtattct acagcctgat gagggagagc     1140

ggctacatgc acatccagtg caccaagcct gacaccgtag gctctgctct gaatgactct     1200

cctgtgggtc tggctgccta tattctagag aagttttcca cctggaccaa tacggaattc     1260

cgatacctgg aggatggagg cctggaaagg aagttctccc tggacgacct gctgaccaac     1320

gtcatgctct actggacaac aggcaccatc atctcctccc agcgcttcta caaggagaac     1380

ctgggacagg gctggatgac ccagaagcat gagcggatga aggtctatgt gcccactggc     1440

ttctctgcct tcccttttga gctattgcac acgcctgaaa agtgggtgag gttcaagtac     1500

ccaaagctca tctcctattc ctacatggtt cgtgggggcc actttgcggc ctttgaggag     1560

ccggagctgc tcgcccagga catccgcaag ttcctgtcgg tgctggagcg gcaatgaccc     1620

acccctctcc ccccgcctgc cacctccccc cacaagtgcc ctccaggctt ttcttgggga     1680

agatacccct tttctgagga atgagtttgc ctccgtcccc tgcccatgct gggagcccac     1740

gctcaccccc tcacccctcc aagctcactc cccaaccccc aactccgtgt ggtaagcaac     1800

atggctttga tgataaacga ctttactcta aaaaaaaaaa aaaaaaa                   1847


<210> 384
<211> 455
<212> PRT
<213> Homo sapiens

<400> 384
Met Trp Leu Glu Ile Leu Leu Thr Ser Val Leu Gly Phe Ala Ile Tyr 
1               5                   10                  15      


Trp Phe Ile Ser Arg Asp Lys Glu Glu Thr Leu Pro Leu Glu Asp Gly 
            20                  25                  30          


Trp Trp Gly Pro Gly Thr Arg Ser Ala Ala Arg Glu Asp Asp Ser Ile 
        35                  40                  45              


Arg Pro Phe Lys Val Glu Thr Ser Asp Glu Glu Ile His Asp Leu His 
    50                  55                  60                  


Gln Arg Ile Asp Lys Phe Arg Phe Thr Pro Pro Leu Glu Asp Ser Cys 
65                  70                  75                  80  


Phe His Tyr Gly Phe Asn Ser Asn Tyr Leu Lys Lys Val Ile Ser Tyr 
                85                  90                  95      


Trp Arg Asn Glu Phe Asp Trp Lys Lys Gln Val Glu Ile Leu Asn Arg 
            100                 105                 110         


Tyr Pro His Phe Lys Thr Lys Ile Glu Gly Leu Asp Ile His Phe Ile 
        115                 120                 125             


His Val Lys Pro Pro Gln Leu Pro Ala Gly His Thr Pro Lys Pro Leu 
    130                 135                 140                 


Leu Met Val His Gly Trp Pro Gly Ser Phe Tyr Glu Phe Tyr Lys Ile 
145                 150                 155                 160 


Ile Pro Leu Leu Thr Asp Pro Lys Asn His Gly Leu Ser Asp Glu His 
                165                 170                 175     


Val Phe Glu Val Ile Cys Pro Ser Ile Pro Gly Tyr Gly Phe Ser Glu 
            180                 185                 190         


Ala Ser Ser Lys Lys Gly Phe Asn Ser Val Ala Thr Ala Arg Ile Phe 
        195                 200                 205             


Tyr Lys Leu Met Leu Arg Leu Gly Phe Gln Glu Phe Tyr Ile Gln Gly 
    210                 215                 220                 


Gly Asp Trp Gly Ser Leu Ile Cys Thr Asn Met Ala Gln Leu Val Pro 
225                 230                 235                 240 


Ser His Val Lys Gly Leu His Leu Asn Met Ala Leu Val Leu Ser Asn 
                245                 250                 255     


Phe Ser Thr Leu Thr Leu Leu Leu Gly Gln Arg Phe Gly Arg Phe Leu 
            260                 265                 270         


Gly Leu Thr Glu Arg Asp Val Glu Leu Leu Tyr Pro Val Lys Glu Lys 
        275                 280                 285             


Val Phe Tyr Ser Leu Met Arg Glu Ser Gly Tyr Met His Ile Gln Cys 
    290                 295                 300                 


Thr Lys Pro Asp Thr Val Gly Ser Ala Leu Asn Asp Ser Pro Val Gly 
305                 310                 315                 320 


Leu Ala Ala Tyr Ile Leu Glu Lys Phe Ser Thr Trp Thr Asn Thr Glu 
                325                 330                 335     


Phe Arg Tyr Leu Glu Asp Gly Gly Leu Glu Arg Lys Phe Ser Leu Asp 
            340                 345                 350         


Asp Leu Leu Thr Asn Val Met Leu Tyr Trp Thr Thr Gly Thr Ile Ile 
        355                 360                 365             


Ser Ser Gln Arg Phe Tyr Lys Glu Asn Leu Gly Gln Gly Trp Met Thr 
    370                 375                 380                 


Gln Lys His Glu Arg Met Lys Val Tyr Val Pro Thr Gly Phe Ser Ala 
385                 390                 395                 400 


Phe Pro Phe Glu Leu Leu His Thr Pro Glu Lys Trp Val Arg Phe Lys 
                405                 410                 415     


Tyr Pro Lys Leu Ile Ser Tyr Ser Tyr Met Val Arg Gly Gly His Phe 
            420                 425                 430         


Ala Ala Phe Glu Glu Pro Glu Leu Leu Ala Gln Asp Ile Arg Lys Phe 
        435                 440                 445             


Leu Ser Val Leu Glu Arg Gln 
    450                 455 


<210> 385
<211> 1857
<212> DNA
<213> Homo sapiens

<400> 385
agttcaccca atggacctgc ctactgcagc gtaggcctcg cctcaacggc aggagagcag       60

gcggctgcgg ttgctgcagc cttcagtctc cacccggact acgccatgtt ggggtttgtg      120

ggtcgggtgg ccgctgctcc ggcctccggg gccttgcgga gactcacccc ttcagcgtcg      180

ctgcccccag ctcagctctt actgcgggcc gctccgacgg cggtccatcc tgtcagggac      240

tatgcggcgc aaacatctcc ttcgccaaaa gcaggcgccg ccaccgggcg catcgtggcg      300

gtcattggcg cagtggtgga cgtccagttt gatgagggac taccaccaat tctaaatgcc      360

ctggaagtgc aaggcaggga gaccagactg gttttggagg tggcccagca tttgggtgag      420

agcacagtaa ggactattgc tatggatggt acagaaggct tggttagagg ccagaaagta      480

ctggattctg gtgcaccaat caaaattcct gttggtcctg agactttggg cagaatcatg      540

aatgtcattg gagaacctat tgatgaaaga ggtcccatca aaaccaaaca atttgctccc      600

attcatgctg aggctccaga gttcatggaa atgagtgttg agcaggaaat tctggtgact      660

ggtatcaagg ttgtcgatct gctagctccc tatgccaagg gtggcaaaat tgggcttttt      720

ggtggtgctg gagttggcaa gactgtactg atcatggagt taatcaacaa tgtcgccaaa      780

gcccatggtg gttactctgt gtttgctggt gttggtgaga ggacccgtga aggcaatgat      840

ttataccatg aaatgattga atctggtgtt atcaacttaa aagatgccac ctctaaggta      900

gcgctggtat atggtcaaat gaatgaacca cctggtgctc gtgcccgggt agctctgact      960

gggctgactg tggctgaata cttcagagac caagaaggtc aagatgtact gctatttatt     1020

gataacatct ttcgcttcac ccaggctggt tcagaggtgt ctgcattatt gggccgaatc     1080

ccttctgctg tgggctatca gcctaccctg gccactgaca tgggtactat gcaggaaaga     1140

attaccacta ccaagaaggg atctatcacc tctgtacagg ctatctatgt gcctgctgat     1200

gacttgactg accctgcccc tgctactacg tttgcccatt tggatgctac cactgtactg     1260

tcgcgtgcca ttgctgagct gggcatctat ccagctgtgg atcctctaga ctccacctct     1320

cgtatcatgg atcccaacat tgttggcagt gagcattacg atgttgcccg tggggtgcaa     1380

aagatcctgc aggactacaa atccctccag gatatcattg ccatcctggg tatggatgaa     1440

ctttctgagg aagacaagtt gaccgtgtcc cgtgcacgga aaatacagcg tttcttgtct     1500

cagccattcc aggttgctga ggtcttcaca ggtcatatgg ggaagctggt acccctgaag     1560

gagaccatca aaggattcca gcagattttg gcaggtgaat atgaccatct cccagaacag     1620

gccttctata tggtgggacc cattgaagaa gctgtggcaa aagctgataa gctggctgaa     1680

gagcattcat cgtgaggggt ctttgtcctc tgtactgtct ctctccttgc ccctaaccca     1740

aaaagcttca tttttctgtg taggctgcac aagagccttg attgaagata tattctttct     1800

gaacagtatt taaggtttcc aataaaatgt acacccctca gaaaaaaaaa aaaaaaa        1857


<210> 386
<211> 529
<212> PRT
<213> Homo sapiens

<400> 386
Met Leu Gly Phe Val Gly Arg Val Ala Ala Ala Pro Ala Ser Gly Ala 
1               5                   10                  15      


Leu Arg Arg Leu Thr Pro Ser Ala Ser Leu Pro Pro Ala Gln Leu Leu 
            20                  25                  30          


Leu Arg Ala Ala Pro Thr Ala Val His Pro Val Arg Asp Tyr Ala Ala 
        35                  40                  45              


Gln Thr Ser Pro Ser Pro Lys Ala Gly Ala Ala Thr Gly Arg Ile Val 
    50                  55                  60                  


Ala Val Ile Gly Ala Val Val Asp Val Gln Phe Asp Glu Gly Leu Pro 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Leu Glu Val Gln Gly Arg Glu Thr Arg Leu Val 
                85                  90                  95      


Leu Glu Val Ala Gln His Leu Gly Glu Ser Thr Val Arg Thr Ile Ala 
            100                 105                 110         


Met Asp Gly Thr Glu Gly Leu Val Arg Gly Gln Lys Val Leu Asp Ser 
        115                 120                 125             


Gly Ala Pro Ile Lys Ile Pro Val Gly Pro Glu Thr Leu Gly Arg Ile 
    130                 135                 140                 


Met Asn Val Ile Gly Glu Pro Ile Asp Glu Arg Gly Pro Ile Lys Thr 
145                 150                 155                 160 


Lys Gln Phe Ala Pro Ile His Ala Glu Ala Pro Glu Phe Met Glu Met 
                165                 170                 175     


Ser Val Glu Gln Glu Ile Leu Val Thr Gly Ile Lys Val Val Asp Leu 
            180                 185                 190         


Leu Ala Pro Tyr Ala Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
        195                 200                 205             


Gly Val Gly Lys Thr Val Leu Ile Met Glu Leu Ile Asn Asn Val Ala 
    210                 215                 220                 


Lys Ala His Gly Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
225                 230                 235                 240 


Arg Glu Gly Asn Asp Leu Tyr His Glu Met Ile Glu Ser Gly Val Ile 
                245                 250                 255     


Asn Leu Lys Asp Ala Thr Ser Lys Val Ala Leu Val Tyr Gly Gln Met 
            260                 265                 270         


Asn Glu Pro Pro Gly Ala Arg Ala Arg Val Ala Leu Thr Gly Leu Thr 
        275                 280                 285             


Val Ala Glu Tyr Phe Arg Asp Gln Glu Gly Gln Asp Val Leu Leu Phe 
    290                 295                 300                 


Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu Val Ser Ala 
305                 310                 315                 320 


Leu Leu Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala 
                325                 330                 335     


Thr Asp Met Gly Thr Met Gln Glu Arg Ile Thr Thr Thr Lys Lys Gly 
            340                 345                 350         


Ser Ile Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp Leu Thr 
        355                 360                 365             


Asp Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp Ala Thr Thr Val 
    370                 375                 380                 


Leu Ser Arg Ala Ile Ala Glu Leu Gly Ile Tyr Pro Ala Val Asp Pro 
385                 390                 395                 400 


Leu Asp Ser Thr Ser Arg Ile Met Asp Pro Asn Ile Val Gly Ser Glu 
                405                 410                 415     


His Tyr Asp Val Ala Arg Gly Val Gln Lys Ile Leu Gln Asp Tyr Lys 
            420                 425                 430         


Ser Leu Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser Glu 
        435                 440                 445             


Glu Asp Lys Leu Thr Val Ser Arg Ala Arg Lys Ile Gln Arg Phe Leu 
    450                 455                 460                 


Ser Gln Pro Phe Gln Val Ala Glu Val Phe Thr Gly His Met Gly Lys 
465                 470                 475                 480 


Leu Val Pro Leu Lys Glu Thr Ile Lys Gly Phe Gln Gln Ile Leu Ala 
                485                 490                 495     


Gly Glu Tyr Asp His Leu Pro Glu Gln Ala Phe Tyr Met Val Gly Pro 
            500                 505                 510         


Ile Glu Glu Ala Val Ala Lys Ala Asp Lys Leu Ala Glu Glu His Ser 
        515                 520                 525             


Ser 
    


<210> 387
<211> 1005
<212> DNA
<213> Homo sapiens

<400> 387
cagacgtccc tgcgcgtcgt cctcctcgcc ctccaggccg cccgcgccgc gccggagtcc       60

gctgtccgcc agctacccgc ttcctgccgc ccgccgctgc catgctgccc gccgcgctgc      120

tccgccgccc gggacttggc cgcctcgtcc gccacgcccg tgcctatgcc gaggccgccg      180

ccgccccggc tgccgcctct ggccccaacc agatgtcctt caccttcgcc tctcccacgc      240

aggtgttctt caacggtgcc aacgtccggc aggtggacgt gcccacgctg accggagcct      300

tcggcatcct ggcggcccac gtgcccacgc tgcaggtcct gcggccgggg ctggtcgtgg      360

tgcatgcaga ggacggcacc acctccaaat actttgtgag cagcggttcc atcgcagtga      420

acgccgactc ttcggtgcag ttgttggccg aagaggccgt gacgctggac atgttggacc      480

tgggggcagc caaggcaaac ttggagaagg cccaggcgga gctggtgggg acagctgacg      540

aggccacgcg ggcagagatc cagatccgaa tcgaggccaa cgaggccctg gtgaaggccc      600

tggagtaggc ggtgcgtacc cggtgtcccg aggcccggcc aggggctggg cagggatgcc      660

aggtgggccc agccagctcc tggggtcccg gccacctggg gaagccgcgc ctgccaagga      720

ggccaccaga gggcagtgca ggcttctgcc tgggccccag gccctgcctg tgttgaaagc      780

tctggggact gggccaggga agctcctcct cagctttgag ctgtggctgc cacccatggg      840

gctctccttc cgcctctcaa gatcccccca gcctgacggg ccgcttacca tcccctctgc      900

cctgcagagc cagccgccaa ggttgacctc agcttcggag ccacctctgg atgaactgcc      960

cccagccccc gccccattaa agacccggaa gcctgaaaaa aaaaa                     1005


<210> 388
<211> 168
<212> PRT
<213> Homo sapiens

<400> 388
Met Leu Pro Ala Ala Leu Leu Arg Arg Pro Gly Leu Gly Arg Leu Val 
1               5                   10                  15      


Arg His Ala Arg Ala Tyr Ala Glu Ala Ala Ala Ala Pro Ala Ala Ala 
            20                  25                  30          


Ser Gly Pro Asn Gln Met Ser Phe Thr Phe Ala Ser Pro Thr Gln Val 
        35                  40                  45              


Phe Phe Asn Gly Ala Asn Val Arg Gln Val Asp Val Pro Thr Leu Thr 
    50                  55                  60                  


Gly Ala Phe Gly Ile Leu Ala Ala His Val Pro Thr Leu Gln Val Leu 
65                  70                  75                  80  


Arg Pro Gly Leu Val Val Val His Ala Glu Asp Gly Thr Thr Ser Lys 
                85                  90                  95      


Tyr Phe Val Ser Ser Gly Ser Ile Ala Val Asn Ala Asp Ser Ser Val 
            100                 105                 110         


Gln Leu Leu Ala Glu Glu Ala Val Thr Leu Asp Met Leu Asp Leu Gly 
        115                 120                 125             


Ala Ala Lys Ala Asn Leu Glu Lys Ala Gln Ala Glu Leu Val Gly Thr 
    130                 135                 140                 


Ala Asp Glu Ala Thr Arg Ala Glu Ile Gln Ile Arg Ile Glu Ala Asn 
145                 150                 155                 160 


Glu Ala Leu Val Lys Ala Leu Glu 
                165             


<210> 389
<211> 3125
<212> DNA
<213> Homo sapiens

<400> 389
agggacttac ccaaggtcac gcagcgagcc cggtccccct gcgttccccg gggagcgctg       60

agccgggacg cggcggtggg gtggggaagg ggagtggcgc ggccctgcgg ggtgaggctg      120

ccgtttgctg agtgtccggc aggggtctgc tcgctgccag cccggcccct cctcagagca      180

gctgccgcag cccgaggatg tcggaggaga tcatcacgcc ggtgtactgc actggggtgt      240

cagcccaagt gcagaagcag cgggccaggg agctgggcct gggccgccat gagaatgcca      300

tcaagtacct gggccaggat tatgagcagc tgcgggtgcg atgcctgcag agtgggaccc      360

tcttccgtga tgaggccttc cccccggtac cccagagcct gggttacaag gacctgggtc      420

ccaattcctc caagacctat ggcatcaagt ggaagcgtcc cacggaactg ctgtcaaacc      480

cccagttcat tgtggatgga gctacccgca cagacatctg ccagggagca ctgggggact      540

gctggctctt ggcggccatc gcctccctca ctctcaacga caccctcctg caccgagtgg      600

ttccgcacgg ccagagcttc cagaatggct atgccggcat cttccatttc cagctgtggc      660

aatttgggga gtgggtggac gtggtcgtgg atgacctgct gcccatcaag gacgggaagc      720

tagtgttcgt gcactctgcc gaaggcaacg agttctggag cgccctgctt gagaaggcct      780

atgccaaggt aaatggcagc tacgaggccc tgtcaggggg cagcacctca gagggctttg      840

aggacttcac aggcggggtt accgagtggt acgagttgcg caaggctccc agtgacctct      900

accagatcat cctcaaggcg ctggagcggg gctccctgct gggctgctcc atagacatct      960

ccagcgttct agacatggag gccatcactt tcaagaagtt ggtgaagggc catgcctact     1020

ctgtgaccgg ggccaagcag gtgaactacc gaggccaggt ggtgagcctg atccggatgc     1080

ggaacccctg gggcgaggtg gagtggacgg gagcctggag cgacagctcc tcagagtgga     1140

acaacgtgga cccatatgaa cgggaccagc tccgggtcaa gatggaggac ggggagttct     1200

ggatgtcatt ccgagacttc atgcgggagt tcacccgcct ggagatctgc aacctcacac     1260

ccgacgccct caagagccgg accatccgca aatggaacac cacactctac gaaggcacct     1320

ggcggcgggg gagcaccgcg gggggctgcc gaaactaccc agccaccttc tgggtgaacc     1380

ctcagttcaa gatccggctg gatgagacgg atgacccgga cgactacggg gaccgcgagt     1440

caggctgcag cttcgtgctc gcccttatgc agaagcaccg tcgccgcgag cgccgcttcg     1500

gccgcgacat ggagactatt ggcttcgcgg tctacgaggt ccctccggag ctggtgggcc     1560

agccggccgt acacttgaag cgtgacttct tcctggccaa tgcgtctcgg gcgcgctcag     1620

agcagttcat caacctgcga gaggtcagca cccgcttccg cctgccaccc ggggagtatg     1680

tggtggtgcc ctccaccttc gagcccaaca aggagggcga cttcgtgctg cgcttcttct     1740

cagagaagag tgctgggact gtggagctgg atgaccagat ccaggccaat ctccccgatg     1800

agcaagtgct ctcagaagag gagattgacg agaacttcaa ggccctcttc aggcagctgg     1860

caggggagga catggagatc agcgtgaagg agttgcggac aatcctcaat aggatcatca     1920

gcaaacacaa agacctgcgg accaagggct tcagcctaga gtcgtgccgc agcatggtga     1980

acctcatgga tcgtgatggc aatgggaagc tgggcctggt ggagttcaac atcctgtgga     2040

accgcatccg gaattacctg tccatcttcc ggaagtttga cctggacaag tcgggcagca     2100

tgagtgccta cgagatgcgg atggccattg agtcggcagg cttcaagctc aacaagaagc     2160

tgtacgagct catcatcacc cgctactcgg agcccgacct ggcggtcgac tttgacaatt     2220

tcgtttgctg cctggtgcgg ctagagacca tgttccgatt tttcaaaact ctggacacag     2280

atctggatgg agttgtgacc tttgacttgt ttaagtggtt gcagctgacc atgtttgcat     2340

gaggcaggga ctcggtcccc cttgccgtgc tcccctccct cctcgtctgc caagcctcgc     2400

ctcctaccac accacaccag gccaccccag ctgcaagtgc cttccttgga gcagagaggc     2460

agcctcgtcc tcctgtcccc tctcctccca gccaccatcg ttcatctgct ccgggcagaa     2520

ctgtgtggcc cctgcctgtg ccagccatgg gctcgggatg gactccctgg gccccaccca     2580

ttgccaagcc aggaaggcag ctttcgcttg ttcctgcctc gggacagccc cgggtttccc     2640

cagcatcctg atgtgtcccc tctccccact tcagaggcca cccactcagc accaccggcc     2700

tggccttgcc tgcagactat aaactataac cactagctcg acacagtctg cagtccaggc     2760

gtgtggagcc gcctcccggc tcggggaggc cccggggctg ggaacgcctg tgccttcctg     2820

cgccgaagcc aacgccccct ctgtccttcc ctggccctgc tgccgaccag gagctgccca     2880

gcctgtgggc ggtcggcctt ccctccttcg ctcctttttt atattagtga ttttaaaggg     2940

gactcttcag ggacttgtgt actggttatg ggggtgccag aggcactagg cttggggtgg     3000

ggaggtcccg tgttccatat agaggaaccc caaataataa aaggccccac atctgtctgt     3060

gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3120

aaaaa                                                                 3125


<210> 390
<211> 714
<212> PRT
<213> Homo sapiens

<400> 390
Met Ser Glu Glu Ile Ile Thr Pro Val Tyr Cys Thr Gly Val Ser Ala 
1               5                   10                  15      


Gln Val Gln Lys Gln Arg Ala Arg Glu Leu Gly Leu Gly Arg His Glu 
            20                  25                  30          


Asn Ala Ile Lys Tyr Leu Gly Gln Asp Tyr Glu Gln Leu Arg Val Arg 
        35                  40                  45              


Cys Leu Gln Ser Gly Thr Leu Phe Arg Asp Glu Ala Phe Pro Pro Val 
    50                  55                  60                  


Pro Gln Ser Leu Gly Tyr Lys Asp Leu Gly Pro Asn Ser Ser Lys Thr 
65                  70                  75                  80  


Tyr Gly Ile Lys Trp Lys Arg Pro Thr Glu Leu Leu Ser Asn Pro Gln 
                85                  90                  95      


Phe Ile Val Asp Gly Ala Thr Arg Thr Asp Ile Cys Gln Gly Ala Leu 
            100                 105                 110         


Gly Asp Cys Trp Leu Leu Ala Ala Ile Ala Ser Leu Thr Leu Asn Asp 
        115                 120                 125             


Thr Leu Leu His Arg Val Val Pro His Gly Gln Ser Phe Gln Asn Gly 
    130                 135                 140                 


Tyr Ala Gly Ile Phe His Phe Gln Leu Trp Gln Phe Gly Glu Trp Val 
145                 150                 155                 160 


Asp Val Val Val Asp Asp Leu Leu Pro Ile Lys Asp Gly Lys Leu Val 
                165                 170                 175     


Phe Val His Ser Ala Glu Gly Asn Glu Phe Trp Ser Ala Leu Leu Glu 
            180                 185                 190         


Lys Ala Tyr Ala Lys Val Asn Gly Ser Tyr Glu Ala Leu Ser Gly Gly 
        195                 200                 205             


Ser Thr Ser Glu Gly Phe Glu Asp Phe Thr Gly Gly Val Thr Glu Trp 
    210                 215                 220                 


Tyr Glu Leu Arg Lys Ala Pro Ser Asp Leu Tyr Gln Ile Ile Leu Lys 
225                 230                 235                 240 


Ala Leu Glu Arg Gly Ser Leu Leu Gly Cys Ser Ile Asp Ile Ser Ser 
                245                 250                 255     


Val Leu Asp Met Glu Ala Ile Thr Phe Lys Lys Leu Val Lys Gly His 
            260                 265                 270         


Ala Tyr Ser Val Thr Gly Ala Lys Gln Val Asn Tyr Arg Gly Gln Val 
        275                 280                 285             


Val Ser Leu Ile Arg Met Arg Asn Pro Trp Gly Glu Val Glu Trp Thr 
    290                 295                 300                 


Gly Ala Trp Ser Asp Ser Ser Ser Glu Trp Asn Asn Val Asp Pro Tyr 
305                 310                 315                 320 


Glu Arg Asp Gln Leu Arg Val Lys Met Glu Asp Gly Glu Phe Trp Met 
                325                 330                 335     


Ser Phe Arg Asp Phe Met Arg Glu Phe Thr Arg Leu Glu Ile Cys Asn 
            340                 345                 350         


Leu Thr Pro Asp Ala Leu Lys Ser Arg Thr Ile Arg Lys Trp Asn Thr 
        355                 360                 365             


Thr Leu Tyr Glu Gly Thr Trp Arg Arg Gly Ser Thr Ala Gly Gly Cys 
    370                 375                 380                 


Arg Asn Tyr Pro Ala Thr Phe Trp Val Asn Pro Gln Phe Lys Ile Arg 
385                 390                 395                 400 


Leu Asp Glu Thr Asp Asp Pro Asp Asp Tyr Gly Asp Arg Glu Ser Gly 
                405                 410                 415     


Cys Ser Phe Val Leu Ala Leu Met Gln Lys His Arg Arg Arg Glu Arg 
            420                 425                 430         


Arg Phe Gly Arg Asp Met Glu Thr Ile Gly Phe Ala Val Tyr Glu Val 
        435                 440                 445             


Pro Pro Glu Leu Val Gly Gln Pro Ala Val His Leu Lys Arg Asp Phe 
    450                 455                 460                 


Phe Leu Ala Asn Ala Ser Arg Ala Arg Ser Glu Gln Phe Ile Asn Leu 
465                 470                 475                 480 


Arg Glu Val Ser Thr Arg Phe Arg Leu Pro Pro Gly Glu Tyr Val Val 
                485                 490                 495     


Val Pro Ser Thr Phe Glu Pro Asn Lys Glu Gly Asp Phe Val Leu Arg 
            500                 505                 510         


Phe Phe Ser Glu Lys Ser Ala Gly Thr Val Glu Leu Asp Asp Gln Ile 
        515                 520                 525             


Gln Ala Asn Leu Pro Asp Glu Gln Val Leu Ser Glu Glu Glu Ile Asp 
    530                 535                 540                 


Glu Asn Phe Lys Ala Leu Phe Arg Gln Leu Ala Gly Glu Asp Met Glu 
545                 550                 555                 560 


Ile Ser Val Lys Glu Leu Arg Thr Ile Leu Asn Arg Ile Ile Ser Lys 
                565                 570                 575     


His Lys Asp Leu Arg Thr Lys Gly Phe Ser Leu Glu Ser Cys Arg Ser 
            580                 585                 590         


Met Val Asn Leu Met Asp Arg Asp Gly Asn Gly Lys Leu Gly Leu Val 
        595                 600                 605             


Glu Phe Asn Ile Leu Trp Asn Arg Ile Arg Asn Tyr Leu Ser Ile Phe 
    610                 615                 620                 


Arg Lys Phe Asp Leu Asp Lys Ser Gly Ser Met Ser Ala Tyr Glu Met 
625                 630                 635                 640 


Arg Met Ala Ile Glu Ser Ala Gly Phe Lys Leu Asn Lys Lys Leu Tyr 
                645                 650                 655     


Glu Leu Ile Ile Thr Arg Tyr Ser Glu Pro Asp Leu Ala Val Asp Phe 
            660                 665                 670         


Asp Asn Phe Val Cys Cys Leu Val Arg Leu Glu Thr Met Phe Arg Phe 
        675                 680                 685             


Phe Lys Thr Leu Asp Thr Asp Leu Asp Gly Val Val Thr Phe Asp Leu 
    690                 695                 700                 


Phe Lys Trp Leu Gln Leu Thr Met Phe Ala 
705                 710                 


<210> 391
<211> 2373
<212> DNA
<213> Homo sapiens

<400> 391
cccctccctt agcgggggcg cgcggcgctg aggaccgcac ggaaacgggg aagtcaggtg       60

gccgctgccg ccgccgccgc cgcggtttgt cgccagaagg aagatggcgg atctggagga      120

gcagttgtct gatgaagaga aggtgcgtat agcagcaaaa ttcatcattc atgcccctcc      180

tggagaattt aatgaggttt tcaatgatgt tcggttactg cttaataatg acaatcttct      240

cagggaagga gcagcccatg catttgcaca gtataacttg gaccagttta ctccagtaaa      300

aattgaaggt tatgaagatc aggtattgat aacagaacat ggcgacttgg gaaatggaaa      360

gtttttggat ccaaagaaca gaatctgttt taaatttgat cacttaagga aggaggcaac      420

tgatccaaga ccctgtgaag tagaaaatgc agttgaatca tggagaactt cagtagaaac      480

tgctctgaga gcttacgtaa aagaacatta cccgaatgga gtctgcactg tgtatggcaa      540

aaaaatagat ggacagcaaa ccattattgc atgcatagaa agccatcagt tccaagcaaa      600

aaatttttgg aatggtcgtt ggaggtcaga atggaagttt acaatcactc cttcaaccac      660

tcaagtggtt ggcatcttga aaattcaggt tcattattat gaagatggta atgttcagct      720

agtgagtcat aaagatatac aagattccct aacagtgtct aatgaagtgc aaacagcaaa      780

agaatttata aagattgtag aagctgcaga aaatgaatac cagactgcca tcagtgagaa      840

ttatcagaca atgtcggaca ctactttcaa agccttacgt cgacagttgc cagttacacg      900

cactaagatt gattggaaca agatccttag ctacaagatt ggcaaagaga tgcagaatgc      960

ataagatgaa cattgcatga ccggatcatt ttagtgtctt tgcgttaaaa aatcattgca     1020

aaagtattct gaactgtcaa gctgcccagt cagatgggct gttgccattt aaaatcactg     1080

taattaatta gtttgattag agcacaaagc ttagctaatc aaccattatt tttcattttg     1140

tttgttctaa gaggattgaa aatcagttta gtttaaatgt ctttctgtta ggcctttctt     1200

tcttacaatg aagagatgat tcttctagtt tatggttaaa agtttttgaa gtgtctcaaa     1260

aatattttac taactgtaac cctaaaattg atgtcttttg gtttatgaaa tcagtaattt     1320

ttgatatttc cccagttctt tttaatgggg tcaataatgg acattctagt ttaaggtggt     1380

tgatggattt agccatatat gctgctaaag aaattgtcta ccttttcttc ctcacctgtt     1440

ccatttatgt aaagttgaga ttagagggaa agcattttct atatcaattg tgtttaaacc     1500

tttcaagaag gttatttagc tagcttagtg ttgaactaaa ttttttttaa acaaggcaag     1560

gtctaatgct gttttgagat tctgaaatta atgaaaatac ttatttcaga aatgcattta     1620

atgctttttt tcttgtgaca gttacgcaaa tcagcttgaa ttccatatgt ccctgagtta     1680

tttttatcat aaagccacaa atgtattata acaaggcaaa ttgtaatata tataatcctg     1740

aactcatgac catgtctcgg tttatttttt ttttcttgga ttgaaaagta ctgaaattca     1800

atgtgacatt aaaatgcaaa ttttcctatt tatttgagta gaaaatcact taccagtgag     1860

catatatatt ttaaaatact ttctttggat attgtaattc ttaactggtt gtaaattaga     1920

aaagctggga ttacatatgg tgtgcggtta cagtctaaat tttttcatcc tcctatgcat     1980

cataagcatg tttgtaatat tttcaaaaat agttctactg atgctacagg aatttcaagc     2040

ctgtggtgaa tgttagtatt taccataggg agtgaagtgg agttatggtt tcattcaata     2100

gagtattgct gattatactt gagtggaatc ctttcctcac gtactcccac agacgtctgg     2160

gcctggaaat ttttttttta ttttatttta ttgttttttt ttttagaaaa acaccacttt     2220

tattatgtac aataaaatat ttcattagct tgaattgtat agatttttaa aaattcaatg     2280

aaagcatgtt gtttaatttc tttttaaaat cactgttggg ctttgaaagc attgagaata     2340

taatatgaaa ttatgaaaaa aaaaaaaaaa aaa                                  2373


<210> 392
<211> 286
<212> PRT
<213> Homo sapiens

<400> 392
Met Ala Asp Leu Glu Glu Gln Leu Ser Asp Glu Glu Lys Val Arg Ile 
1               5                   10                  15      


Ala Ala Lys Phe Ile Ile His Ala Pro Pro Gly Glu Phe Asn Glu Val 
            20                  25                  30          


Phe Asn Asp Val Arg Leu Leu Leu Asn Asn Asp Asn Leu Leu Arg Glu 
        35                  40                  45              


Gly Ala Ala His Ala Phe Ala Gln Tyr Asn Leu Asp Gln Phe Thr Pro 
    50                  55                  60                  


Val Lys Ile Glu Gly Tyr Glu Asp Gln Val Leu Ile Thr Glu His Gly 
65                  70                  75                  80  


Asp Leu Gly Asn Gly Lys Phe Leu Asp Pro Lys Asn Arg Ile Cys Phe 
                85                  90                  95      


Lys Phe Asp His Leu Arg Lys Glu Ala Thr Asp Pro Arg Pro Cys Glu 
            100                 105                 110         


Val Glu Asn Ala Val Glu Ser Trp Arg Thr Ser Val Glu Thr Ala Leu 
        115                 120                 125             


Arg Ala Tyr Val Lys Glu His Tyr Pro Asn Gly Val Cys Thr Val Tyr 
    130                 135                 140                 


Gly Lys Lys Ile Asp Gly Gln Gln Thr Ile Ile Ala Cys Ile Glu Ser 
145                 150                 155                 160 


His Gln Phe Gln Ala Lys Asn Phe Trp Asn Gly Arg Trp Arg Ser Glu 
                165                 170                 175     


Trp Lys Phe Thr Ile Thr Pro Ser Thr Thr Gln Val Val Gly Ile Leu 
            180                 185                 190         


Lys Ile Gln Val His Tyr Tyr Glu Asp Gly Asn Val Gln Leu Val Ser 
        195                 200                 205             


His Lys Asp Ile Gln Asp Ser Leu Thr Val Ser Asn Glu Val Gln Thr 
    210                 215                 220                 


Ala Lys Glu Phe Ile Lys Ile Val Glu Ala Ala Glu Asn Glu Tyr Gln 
225                 230                 235                 240 


Thr Ala Ile Ser Glu Asn Tyr Gln Thr Met Ser Asp Thr Thr Phe Lys 
                245                 250                 255     


Ala Leu Arg Arg Gln Leu Pro Val Thr Arg Thr Lys Ile Asp Trp Asn 
            260                 265                 270         


Lys Ile Leu Ser Tyr Lys Ile Gly Lys Glu Met Gln Asn Ala 
        275                 280                 285     


<210> 393
<211> 1948
<212> DNA
<213> Homo sapiens

<400> 393
atagagtagc ggaagtggtc cgttctcttc ctctcccggc ccaagcttct gggtatttct       60

attgcgcgag gcattgtggg ttgctgggcg gcccggtctc ggagaagagg ggagagtggc      120

gggccgctga ataagcttcc aaaatgatgc ccacaccagt tatcctattg aaagagggga      180

ctgatagctc ccaaggcatc ccccagcttg tgagtaacat cagtgcctgc caggtgattg      240

ctgaggctgt aagaactacc ctgggtcccc gtggcatgga caagcttatt gtagatggca      300

gaggcaaagc aacaatttct aatgatgggg ccacaattct gaaacttctt gatgttgtcc      360

atcctgcagc aaagactttg gtagacattg ccaaatccca agatgctgag gtgggtgatg      420

gcaccacctc agtgaccttg ctggctgcag agtttctgaa gcaggtgaaa ccctatgtgg      480

aggaaggttt acacccccag atcatcattc gagctttccg cacagccacc cagctggcag      540

ttaacaagat caaagagatt gctgtgaccg tgaagaaggc agataaagtg gagcagagga      600

agctgctgga aaagtgtgcc atgaccgctc tgagctccaa gctgatctcc cagcagaaag      660

ctttctttgc taagatggtg gtggatgcag tgatgatgct cgatgatttg ctgcagctta      720

aaatgattgg aatcaagaag gtacagggtg gagccctcga ggattctcag ctggtagctg      780

gtgttgcatt caagaagact ttctcttacg ctgggtttga aatgcaaccc aaaaagtacc      840

acaatcccaa gattgccctt ttgaatgtcg agctcgagtt gaaagctgag aaagacaatg      900

ctgagataag agtccacaca gttgaggatt atcaggcaat tgttgatgct gagtggaaca      960

ttctctatga caagttagag aagatccatc attctggagc caaagttgtc ttgtccaaac     1020

tccccattgg ggatgtggcc acccagtact ttgctgacag ggacatgttc tgtgctggcc     1080

gagtacctga ggaggatctg aagaggacaa tgatggcctg tggaggctca atccagacca     1140

gtgtgaatgc tctgtcagca gatgtgctgg gtcgatgcca ggtgtttgaa gagacccaga     1200

ttggaggcga gaggtacaat ttttttactg gctgccccaa ggccaagaca tgcaccttca     1260

ttctccgtgg cggcgccgag cagtttatgg aggagacaga gcggtccctg catgatgcca     1320

tcatgatcgt caggagggcc atcaagaatg attcagtggt ggctggtggc ggggccattg     1380

agatggaact ctccaagtac ctgcgggatt actcaaggac tattccagga aaacagcagc     1440

tgttgattgg ggcatatgcc aaggccttgg agattatccc acgccagctg tgtgacaatg     1500

ctggctttga tgccacaaac attctcaaca agctgcgggc tcggcatgcc caggggggta     1560

catggtatgg agtagacatc aacaacgagg acattgctga caactttgaa gctttcgtgt     1620

gggagccagc tatggtgcgg atcaatgcgc tgacagcagc ctctgaggct gcgtgcctga     1680

tcgtgtctgt agatgaaacc atcaagaacc cccgctcgac tgtggatgct cccacagcag     1740

caggccgggg ccgtggtcgt ggccgccccc actgagaggc accccaccca tcacatggct     1800

ggctggctgc tgggtgcact taccctcctt ggcttggtta cttcatttta caaggaaggg     1860

gtagtaattg gcccactctc ttcttactgg aggctattta aataaaatgt aagacttcag     1920

ataactttgt aaattaaaaa aaaaaaaa                                        1948


<210> 394
<211> 543
<212> PRT
<213> Homo sapiens

<400> 394
Met Met Pro Thr Pro Val Ile Leu Leu Lys Glu Gly Thr Asp Ser Ser 
1               5                   10                  15      


Gln Gly Ile Pro Gln Leu Val Ser Asn Ile Ser Ala Cys Gln Val Ile 
            20                  25                  30          


Ala Glu Ala Val Arg Thr Thr Leu Gly Pro Arg Gly Met Asp Lys Leu 
        35                  40                  45              


Ile Val Asp Gly Arg Gly Lys Ala Thr Ile Ser Asn Asp Gly Ala Thr 
    50                  55                  60                  


Ile Leu Lys Leu Leu Asp Val Val His Pro Ala Ala Lys Thr Leu Val 
65                  70                  75                  80  


Asp Ile Ala Lys Ser Gln Asp Ala Glu Val Gly Asp Gly Thr Thr Ser 
                85                  90                  95      


Val Thr Leu Leu Ala Ala Glu Phe Leu Lys Gln Val Lys Pro Tyr Val 
            100                 105                 110         


Glu Glu Gly Leu His Pro Gln Ile Ile Ile Arg Ala Phe Arg Thr Ala 
        115                 120                 125             


Thr Gln Leu Ala Val Asn Lys Ile Lys Glu Ile Ala Val Thr Val Lys 
    130                 135                 140                 


Lys Ala Asp Lys Val Glu Gln Arg Lys Leu Leu Glu Lys Cys Ala Met 
145                 150                 155                 160 


Thr Ala Leu Ser Ser Lys Leu Ile Ser Gln Gln Lys Ala Phe Phe Ala 
                165                 170                 175     


Lys Met Val Val Asp Ala Val Met Met Leu Asp Asp Leu Leu Gln Leu 
            180                 185                 190         


Lys Met Ile Gly Ile Lys Lys Val Gln Gly Gly Ala Leu Glu Asp Ser 
        195                 200                 205             


Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe Ser Tyr Ala Gly 
    210                 215                 220                 


Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys Ile Ala Leu Leu 
225                 230                 235                 240 


Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn Ala Glu Ile Arg 
                245                 250                 255     


Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp Ala Glu Trp Asn 
            260                 265                 270         


Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser Gly Ala Lys Val 
        275                 280                 285             


Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr Gln Tyr Phe Ala 
    290                 295                 300                 


Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu Glu Asp Leu Lys 
305                 310                 315                 320 


Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr Ser Val Asn Ala 
                325                 330                 335     


Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe Glu Glu Thr Gln 
            340                 345                 350         


Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys Pro Lys Ala Lys 
        355                 360                 365             


Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln Phe Met Glu Glu 
    370                 375                 380                 


Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val Arg Arg Ala Ile 
385                 390                 395                 400 


Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile Glu Met Glu Leu 
                405                 410                 415     


Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro Gly Lys Gln Gln 
            420                 425                 430         


Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile Ile Pro Arg Gln 
        435                 440                 445             


Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile Leu Asn Lys Leu 
    450                 455                 460                 


Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly Val Asp Ile Asn 
465                 470                 475                 480 


Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val Trp Glu Pro Ala 
                485                 490                 495     


Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu Ala Ala Cys Leu 
            500                 505                 510         


Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg Ser Thr Val Asp 
        515                 520                 525             


Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly Arg Pro His 
    530                 535                 540             


<210> 395
<211> 3783
<212> DNA
<213> Homo sapiens

<400> 395
ggggcggggc cgggagggta cttagggccg gggctggccc aggctacggc ggctgcaggg       60

ctccggcaac cgctccggca acgccaaccg ctccgctgcg cgcaggctgg gctgcaggct      120

ctcggctgca gcgctgggtg gatctaggat ccggcttcca acatgtggca gctctgggcc      180

tccctctgct gcctgctggt gttggccaat gcccggagca ggccctcttt ccatcccctg      240

tcggatgagc tggtcaacta tgtcaacaaa cggaatacca cgtggcaggc cgggcacaac      300

ttctacaacg tggacatgag ctacttgaag aggctatgtg gtaccttcct gggtgggccc      360

aagccacccc agagagttat gtttaccgag gacctgaagc tgcctgcaag cttcgatgca      420

cgggaacaat ggccacagtg tcccaccatc aaagagatca gagaccaggg ctcctgtggc      480

tcctgctggg ccttcggggc tgtggaagcc atctctgacc ggatctgcat ccacaccaat      540

gcgcacgtca gcgtggaggt gtcggcggag gacctgctca catgctgtgg cagcatgtgt      600

ggggacggct gtaatggtgg ctatcctgct gaagcttgga acttctggac aagaaaaggc      660

ctggtttctg gtggcctcta tgaatcccat gtagggtgca gaccgtactc catccctccc      720

tgtgagcacc acgtcaacgg ctcccggccc ccatgcacgg gggagggaga tacccccaag      780

tgtagcaaga tctgtgagcc tggctacagc ccgacctaca aacaggacaa gcactacgga      840

tacaattcct acagcgtctc caatagcgag aaggacatca tggccgagat ctacaaaaac      900

ggccccgtgg agggagcttt ctctgtgtat tcggacttcc tgctctacaa gtcaggagtg      960

taccaacacg tcaccggaga gatgatgggt ggccatgcca tccgcatcct gggctgggga     1020

gtggagaatg gcacacccta ctggctggtt gccaactcct ggaacactga ctggggtgac     1080

aatggcttct ttaaaatact cagaggacag gatcactgtg gaatcgaatc agaagtggtg     1140

gctggaattc cacgcaccga tcagtactgg gaaaagatct aatctgccgt gggcctgtcg     1200

tgccagtcct gggggcgaga tcggggtaga aatgcatttt attctttaag ttcacgtaag     1260

atacaagttt cagacagggt ctgaaggact ggattggcca aacatcagac ctgtcttcca     1320

aggagaccaa gtcctggcta catcccagcc tgtggttaca gtgcagacag gccatgtgag     1380

ccaccgctgc cagcacagag cgtccttccc cctgtagact agtgccgtag ggagtacctg     1440

ctgccccagc tgactgtggc cccctccgtg atccatccat ctccagggag caagacagag     1500

acgcaggaat ggaaagcgga gttcctaaca ggatgaaagt tcccccatca gttcccccag     1560

tacctccaag caagtagctt tccacatttg tcacagaaat cagaggagag acggtgttgg     1620

gagccctttg gagaacgcca gtctcccagg ccccctgcat ctatcgagtt tgcaatgtca     1680

caacctctct gatcttgtgc tcagcatgat tctttaatag aagttttatt ttttcgtgca     1740

ctctgctaat catgtgggtg agccagtgga acagcgggag acctgtgcta gttttacaga     1800

ttgcctcctt atgacgcggc tcaaaaggaa accaagtggt caggagttgt ttctgaccca     1860

ctgatctcta ctaccacaag gaaaatagtt taggagaaac cagcttttac tgtttttgaa     1920

aaattacagc ttcaccctgt caagttaaca aggaatgcct gtgccaataa aagttttctc     1980

caacttgaag tctactctga tgggatctca gatcctttgt cactgcctat agacttgtag     2040

ctgctgtctc tctttgtccc tgcagagaat cacgtcctgg aactgcatgt tcttgcgact     2100

cttgggactt catcttaact tctcgctgcc ccagccatgt tttcaaccat ggcatccctc     2160

ccccaattag ttccctgtca tcctcgtcaa ccttctctgt aagtgcctgg taagcttgcc     2220

cttgcttaag aactcaaaac atagctgtgc tctatttttt tgttgttgtt gtgactgaca     2280

gagtgagatt ccgtctccca ggctggagtg cagtggcgcc ttctcagctc actgcaacct     2340

gcagcctcct agattcaagc gattctcctg cttcagcctt ccgagtagct gggatgacag     2400

gcactcacca atatgcctgg gtaatttttg tatttttaag tacatacagg atttcaccat     2460

gttggccagg ctagtttcaa actcccggcc tcaggtggtc tgcctgcctc agcctcccaa     2520

agtgttggga ttacaggcgt gagccactgg gccctgcctg tattttttat cagccacaaa     2580

tccagcaaca agctgaggat tcagctcata aaacaggctt ggtgtcttgg tgatctcaca     2640

taaccaagat gctaccccgt ggggaaccac atccccctgg atgccctcca gccttggttt     2700

gggctggagt cagggcctgt atacagtatt ttgaatttgt atgccactgg tttgcattgc     2760

tggtcaggaa ctctagtgct ttgcatagcc ctggtttaga aacatgttat agcagttctt     2820

ggtatagagc aaactagaag aaccagcaat cattccactg tcctgccaag gtacacctca     2880

gtactcccct tcccaactga agtggtatga ggctagctct ttccaaaagc attcaagttt     2940

ggcttctgat gtgactcaga atttaggaac cagatgctag atcaaataag ctctgaaaat     3000

ctgaggaaca ttgtaggaaa ggtttgttaa gcatctctta agtgccatga tgagcataac     3060

agccggccgt cgtggctcac gcctgtaatc ccagcacttt gggaggccaa ggtgggagga     3120

tgacaaggtc aggagttcaa gaccagcctg gccaacatgc tgaaacctca cctctactaa     3180

aaatacaaaa attagctggg catggtggca catgcctgta atcccagcta cttgggaggc     3240

tgaggcagga gaatcgcttg aacccgggag gcggaggttg cagtgagcca agacagtgcc     3300

agtgcactcc agcctcggtg acagcgcaag gctccgtctc aataattaaa aaaaaaaaaa     3360

aaaaaaaaaa ggccgggcgc agtggctcaa gcctgtaatc ccagcacttt gggaggctga     3420

ggcgggcaga tcacctgagg tcaggagttt tgagatcagc cttggcaaca cggtgaaacc     3480

ccatctctac taaaaataca aaattagcca agcatgctgg cacatgcctg taatcccagc     3540

tactcgggag gctgaggtac gagaatcgct tgaacctggg aggcagagga tgcagtgagc     3600

cgagatcacg ccattgcact ccagcctggg ggacaagagt gaatctgtgt ctcaccaaaa     3660

aaaaaaagaa aaagaaagat gcttaacaaa ggttaccata agccacaaat tcataaccac     3720

ttatccttcc agtttcaagt agaatatatt cataacctca ataaagttct ccctgctccc     3780

aaa                                                                   3783


<210> 396
<211> 339
<212> PRT
<213> Homo sapiens

<400> 396
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210> 397
<211> 747
<212> DNA
<213> Homo sapiens

<400> 397
gccggaagtg acgcagggca gcggcgtcgc gggggcgggg ctcgggaaag acccgtgcca       60

gcgggcgtgt ggccgcgggt ttcgcacggt ccaataaggg agggcggcgt ggcccggcct      120

ggtagcgacg aggacgcgcc tgcgcagagg cggcagcacc accggggttg actccggggg      180

cgcggcgagg agagacatga ggctgagctg gttccgggtc ctgacagtac tgtccatctg      240

cctgagcgcc gtggccacgg ccacgggggc cgagggcaaa aggaagctgc agatcggggt      300

caagaagcgg gtggaccact gtcccatcaa atcgcgcaaa ggggatgtcc tgcacatgca      360

ctacacgggg aagctggaag atgggacaga gtttgacagc agcctgcccc agaaccagcc      420

ctttgtcttc tcccttggca caggccaggt catcaagggc tgggaccagg ggctgctggg      480

gatgtgtgag ggggaaaagc gcaagctggt gatcccatcc gagctagggt atggagagcg      540

gggagctccc ccaaagattc caggcggtgc aaccctggtg ttcgaggtgg agctgctcaa      600

aatagagcga cgaactgagc tgtaaccaga ctggggaggg gcagggggag aggcccccat      660

cagggaccag actgttccaa aaaaaaaaca aaaaacaaaa acaaacaaaa aaacacttaa      720

aagcccaagg aaaaaaaaaa aaaaaaa                                          747


<210> 398
<211> 142
<212> PRT
<213> Homo sapiens

<400> 398
Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu 
1               5                   10                  15      


Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys Arg Lys Leu Gln 
            20                  25                  30          


Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys 
        35                  40                  45              


Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr 
    50                  55                  60                  


Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu 
65                  70                  75                  80  


Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met 
                85                  90                  95      


Cys Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser Glu Leu Gly Tyr 
            100                 105                 110         


Gly Glu Arg Gly Ala Pro Pro Lys Ile Pro Gly Gly Ala Thr Leu Val 
        115                 120                 125             


Phe Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr Glu Leu 
    130                 135                 140         


<210> 399
<211> 9149
<212> DNA
<213> Homo sapiens

<400> 399
ccctggaggg agagagagcc agagagcggc cgagcgccta ggaggcccgc cgagcctcgc       60

cgagccccgc cagccccggc gcgagagaag ttggagagga gagcagcgca gcgcagcgag      120

tcccgtggtc gcgccccaac agcgcccgac agcccccgat agcccaaacc gcggccctag      180

ccccggccgc acccccagcc cgcgccagca tgatgaacaa cagcggctac tcagacgccg      240

gcctcggcct gggcgatgag acagacgaga tgccgtccac ggagaaggac ctggcggagg      300

acgcgccgtg gaagaagatc cagcagaaca cattcacgcg ctggtgcaat gagcacctca      360

agtgcgtggg caagcgcctg accgacctgc agcgcgacct cagcgacggg ctccggctca      420

tcgcgctgct cgaggtgctc agccagaagc gcatgtaccg caagttccat ccgcgcccca      480

acttccgcca aatgaagctg gagaacgtgt ccgtggccct cgagttcctc gagcgcgagc      540

acatcaagct cgtgtccata gacagcaagg ccatcgtgga tgggaacctg aagctgatcc      600

tgggcctgat ctggacgctg atcctgcact actccatctc catgcccatg tgggaggatg      660

aagatgatga ggatgcccgc aaacagacgc ccaagcagcg gctgcttggc tggatccaga      720

acaaggtgcc ccagctgccc atcaccaact tcaaccgtga ctggcaggac ggcaaagctc      780

tgggcgccct ggtggacaac tgcgcccccg gtctctgccc cgactgggag gcctgggacc      840

ccaaccagcc cgtggagaac gcccgggagg ccatgcagca ggccgacgac tggcttgggg      900

tgccccaggt cattgcccct gaggagattg tggaccccaa cgtggatgag cattctgtta      960

tgacctacct gtcccagttc cccaaggcca agctcaaacc tggtgcccct gttcgatcca     1020

agcagctgaa ccccaagaaa gccatcgcct atgggcctgg catcgagcca cagggcaaca     1080

ccgtgctgca gcctgcccac ttcaccgtgc agacggtgga cgcgggcgtg ggcgaggtgc     1140

tggtctacat cgaggaccct gaaggccaca ccgaggaggc taaggtggtt cccaacaatg     1200

acaaggatcg cacctatgct gtctcctatg tgcccaaggt cgctgggtta cacaaggtga     1260

ccgtgctctt tgctggccag aacattgaac gcagtccctt tgaggtgaac gtgggcatgg     1320

ccctgggaga tgccaacaag gtgtcagccc gtggccctgg cctggaacct gtgggcaatg     1380

tggccaacaa acccacctac tttgacatct acactgcggg ggccggcact ggcgatgttg     1440

ctgtggtgat cgtggaccca cagggccggc gggacacagt ggaggtggcc ctggaggaca     1500

agggtgacag cacgttccgc tgcacataca gacctgccat ggaggggcca cataccgtgc     1560

atgtggcctt tgcgggtgcc cccatcaccc gcagtccctt ccctgtccat gtgtcggaag     1620

cctgtaaccc caacgcctgc cgcgcctctg ggcgaggcct gcagcccaag ggtgttcgcg     1680

tgaaagaggt ggctgacttc aaggtgttta ccaagggtgc cggcagcggg gagctcaagg     1740

tcacggtcaa ggggccaaag ggcacagagg agccagtgaa ggtgcgggag gctggggatg     1800

gtgtgttcga gtgcgagtac tacccggtgg tgcctgggaa gtatgtggtg accatcacgt     1860

ggggcggcta cgccatccct cgcagcccct ttgaggtaca ggtgagccca gaggcaggag     1920

tgcaaaaggt ccgggcctgg ggtcctggtt tggagactgg ccaggtgggc aagtcagccg     1980

attttgtggt ggaagccatt ggcaccgagg tggggacact gggcttctcc atcgaggggc     2040

cctcacaagc caagatcgaa tgtgacgaca agggggatgg ctcctgcgat gtgcggtact     2100

ggcccacgga gcctggggag tacgctgtgc acgtcatctg tgacgatgag gacatccgag     2160

actcaccctt cattgcccac atcctgcccg ccccacctga ctgcttccca gataaggtga     2220

aggcctttgg gcctggcctg gagcctaccg gctgcatcgt ggacaagccc gctgagttca     2280

ccattgatgc tcgtgcagct ggcaagggag acctgaagct ctatgcccag gacgccgacg     2340

gctgtcccat cgacatcaag gtgatcccca acggcgacgg caccttccgc tgctcctacg     2400

tgcccaccaa gcccattaag cacaccatca tcatctcctg gggaggcgta aacgtgccca     2460

agagcccctt ccgggtgaac gtgggcgagg gcagccaccc cgagcgggta aaggtgtacg     2520

gccccggagt ggagaagaca ggcctcaagg ccaatgagcc cacctacttc acggtggact     2580

gcagcgaggc ggggcaaggc gacgtgagca tcggcatcaa gtgcgcccca ggcgtggtgg     2640

gccctgcaga ggctgacatt gacttcgaca tcatcaagaa tgacaacgac accttcaccg     2700

tcaagtacac gccaccaggg gcgggccgct acaccatcat ggtgctgttt gccaaccagg     2760

agatccccgc cagccccttc cacatcaagg tggacccatc ccacgatgcc agcaaagtca     2820

aggccgaggg ccctgggctg aatcgcacag gtgtggaagt cgggaagccc acccacttca     2880

cggtgctgac caagggagcc ggcaaggcca agctggatgt gcagtttgca gggacagcca     2940

agggcgaggt tgtgcgggac tttgagatca tagacaacca tgactactcc tacactgtca     3000

agtacaccgc tgtccagcag ggcaacatgg cagtgacagt gacttatggc ggggaccctg     3060

tccccaagag cccctttgtg gtgaatgtgg cacccccgct ggacctcagc aaaatcaaag     3120

ttcagggcct taatagcaag gtggctgtgg gacaggaaca agcattctct gtgaacacac     3180

gaggggctgg cggtcagggc caactggatg tgcggatgac ttcgccctct cgccggccca     3240

tcccctgcaa gctggagcca ggcggtggag cggaagccca ggctgtgcgc tacatgcccc     3300

cggaggaggg gccctacaag gtggatatca cctacgatgg tcacccggtg cctggcagcc     3360

cgtttgctgt ggagggtgtc ctgccccctg atccctccaa ggtctgtgct tatggcccgg     3420

gtctcaaggg tggactggta ggcacccccg cgccattctc catcgacacc aagggggctg     3480

gcacaggtgg cctggggctg accgtagagg gcccctgcga ggccaagatc gagtgccagg     3540

acaatggtga tggctcatgt gctgtcagct acctgcccac ggagcctggc gagtacacca     3600

tcaacatcct gtttgctgag gcccacatcc ctggctcgcc cttcaaagcc accattcggc     3660

ctgtgtttga cccgagcaag gtgcgggcca gtggaccggg cctggagcgc ggcaaggtcg     3720

gtgaggcagc caccttcact gtggactgct cagaggcagg cgaggcggag ctgaccattg     3780

agatcctgtc ggatgccggg gtcaaggccg aggtgctgat ccacaacaac gcggatggca     3840

cctaccacat cacctacagc cctgccttcc ctggcaccta caccattacc atcaagtatg     3900

gcgggcatcc cgtgcccaaa ttccccaccc gtgtccatgt gcagcctgcg gtcgatacca     3960

gtggcgtcaa ggtctcaggg cctggtgttg agccacacgg tgtcctgcgg gaggtgacca     4020

ctgagttcac tgtggatgca agatccctaa cagccacagg cggcaaccac gtgacggctc     4080

gtgtgctcaa cccctcgggg gccaagacag acacctatgt gacagacaat ggggacggca     4140

cctaccgagt gcagtacacc gcctacgagg agggcgtgca tctggtggag gtcctgtatg     4200

atgaggtcgc tgtgcccaag agccccttcc gagtgggcgt gaccgagggc tgtgatccca     4260

cccgcgtccg agccttcggg ccaggcctgg agggtggctt ggtcaacaag gccaaccgat     4320

tcactgtgga gaccagggga gcgggcaccg ggggccttgg cctagccatc gagggtccct     4380

cggaagccaa gatgtcctgc aaggacaaca aggatggtag ctgcaccgtg gagtacatcc     4440

ccttcactcc tggagactat gacgtcaaca tcaccttcgg ggggcggccc atcccaggga     4500

gcccgttccg cgtgccagtg aaggatgtgg tggaccctgg gaaggtgaag tgctcagggc     4560

cagggctggg ggctggtgtc agggcccggg ttcctcagac cttcacagtg gactgcagtc     4620

aagctggccg ggcgcccctg caggtggctg tgctgggccc cacaggtgtg gccgagcctg     4680

tggaggtgcg ggacaatgga gatggcaccc acactgtcca ctacacccca gccactgacg     4740

ggccctacac ggtagccgtc aagtatgctg accaggaggt gccacgcagc cccttcaaga     4800

tcaaggtcct cccagctcat gatgccagca aggtgcgggc cagcggccca ggcctcaacg     4860

cctctggcat ccctgccagc ctgcctgtgg agttcaccat cgacgcacgg gacgcgggcg     4920

aggggttgct cactgtccag atcttggacc ccgagggtaa gcccaagaag gccaacatcc     4980

gggacaatgg ggatggcacg tacactgtgt cctacctgcc ggacatgagt ggccggtaca     5040

ccatcaccat caagtatggc ggtgatgaga tcccctactc gcccttccgc atccatgctc     5100

tgcccactgg ggatgccagc aagtgcctcg tcacagtgtc cattggaggc catggcctgg     5160

gtgcctgcct gggccctcga atccagattg ggcaggagac ggtgatcacg gtggatgcca     5220

aggcagccgg tgaggggaag gtgacatgca cggtgtccac gccggatggg gcagagctcg     5280

atgtggatgt ggttgagaac catgacggta cctttgacat ctactacaca gcgcccgagc     5340

cgggcaagta cgtcatcacc atccgcttcg ggggtgagca catccccaac agccccttcc     5400

acgtgctggc gtgtgacccc ctgccgcacg aggaggagcc ctctgaagtg ccacagctgc     5460

gccagcccta cgctcctccc cggcccggcg cccgccccac acactgggcc acagaggagc     5520

cagtggtgcc tgtggagcca atggagtcca tgctgaggcc cttcaacctg gtcatcccct     5580

tcgcggtgca gaaaggggag ctcacaggag aggtgcggat gccctcgggg aagacggcac     5640

ggcccaacat caccgacaac aaggacggca ccatcacggt gaggtatgca cccactgaga     5700

aaggcctgca ccagatgggg atcaagtatg acggcaacca catccctggg agccccttac     5760

agttctatgt ggatgccatc aacagccgcc atgtcagtgc ctatgggcca ggcctgagcc     5820

atggcatggt caacaagcca gccaccttca ctattgtcac caaagatgct ggagaagggg     5880

gtctgtcact ggccgtggag ggcccatcca aggcagagat cacctgtaag gacaacaagg     5940

atggcacctg caccgtgtcc tatctgccga ctgcgcctgg agactacagc atcatcgtgc     6000

gcttcgatga caagcacatc ccggggagcc ccttcacagc caagatcaca ggtgatgact     6060

ccatgaggac ctcacagctg aatgtgggca cctccacgga cgtgtcactg aagatcaccg     6120

agagtgatct gagccagctg accgccagca tccgtgcccc ctcgggcaac gaggagccct     6180

gcctgctgaa gcgcctgccc aaccggcaca ttgggatctc cttcaccccc aaggaggtcg     6240

gggagcacgt ggtgagcgtg cgcaagagtg gcaagcatgt caccaacagc cccttcaaga     6300

tcctggtggg gccatctgag atcggggacg ccagcaaggt gcgggtctgg ggcaaggggc     6360

tttccgaggg acacacattc caggtggcag agttcatcgt ggacactcgc aatgcaggtt     6420

atgggggctt ggggctgagt attgaaggcc caagcaaggt ggacatcaac tgtgaggaca     6480

tggaggacgg gacatgcaaa gtcacctact gccccaccga gcccggcacc tacatcatca     6540

acatcaagtt tgctgacaag cacgtgcctg gaagcccctt cactgtgaag gtgaccggcg     6600

agggccgcat gaaggagagc atcacccggc ggagacaggc accttccatc gccaccatcg     6660

gcagcacctg tgacctcaac ctcaagatcc caggaaactg gttccagatg gtgtctgccc     6720

aggagcgcct gacacgcacc ttcacacgca gcagccacac ctacacccgc acggagcgca     6780

cggagatcag caagacgcgg ggcggggaga caaagcgcga ggtgcgggtg gaggagtcca     6840

cccaggtcgg cggggacccc ttccctgctg tgtttgggga cttcctgggc cgggagcgcc     6900

tgggatcctt cggcagcatc acccggcagc aggagggtga ggccagctct caggacatga     6960

ctgcacaggt gaccagccca tcgggcaagg tggaagccgc agagatcgtc gagggcgagg     7020

acagcgccta cagcgtgcgc tttgtgcccc aggaaatggg gccccatacg gtcgctgtca     7080

agtaccgtgg ccagcacgtg cccggcagcc cctttcagtt cactgtgggg ccgctgggtg     7140

aaggtggtgc ccacaaggtg cgggccggag gcacagggct ggagcgaggt gtggccggcg     7200

tgccagccga gttcagcatc tggacccggg aggctggcgc tgggggcctg tccattgctg     7260

tggagggtcc tagcaaagcg gagattgcat ttgaggatcg caaagatggc tcctgcggcg     7320

tctcctatgt cgtccaggaa ccaggtgact atgaggtctc catcaagttc aatgatgagc     7380

acatcccaga cagccccttt gtggtgcctg tggcctccct ctcggatgac gctcgccgtc     7440

tcactgtcac cagcctccag gagacggggc tcaaggtgaa ccagccagcg tcctttgccg     7500

tgcagctgaa cggtgcccgg ggcgtgattg atgcccgggt gcacacaccc tcgggggctg     7560

tggaggagtg ctacgtctct gagctggaca gtgacaagca caccatccgc ttcatccccc     7620

acgagaatgg cgtccactcc atcgatgtca agttcaacgg tgcccacatc cctggaagtc     7680

ccttcaagat ccgcgttggg gagcagagcc aggctgggga cccaggcttg gtgtcagcct     7740

acggtcctgg gctcgaggga ggcactaccg gtgtgtcatc agagttcatc gtgaacaccc     7800

tgaatgccgg ctcgggggcc ttgtctgtca ccattgatgg cccctccaag gtgcagctgg     7860

actgtcggga gtgtcctgag ggccatgtgg tcacttatac tcccatggcc cctggcaact     7920

acctcattgc catcaagtac ggtggccccc agcacatcgt gggcagcccc ttcaaggcca     7980

aggtcactgg tccgaggctg tccggaggcc acagccttca cgaaacatcc acggttctgg     8040

tggagactgt gaccaagtcc tcctcaagcc ggggctccag ctacagctcc atccccaagt     8100

tctcctcaga tgccagcaag gtggtgactc ggggccctgg gctgtcccag gccttcgtgg     8160

gccagaagaa ctccttcacc gtggactgca gcaaagcagg caccaacatg atgatggtgg     8220

gcgtgcacgg ccccaagacc ccctgtgagg aggtgtacgt gaagcacatg gggaaccggg     8280

tgtacaatgt cacctacact gtcaaggaga aaggggacta catcctcatt gtcaagtggg     8340

gtgacgaaag tgtccctgga agccccttca aagtcaaggt cccttgaatc ccaaaagtgc     8400

ctccccagcc tcagccccca cctccagcca cacacacatt acacacacac acacacacac     8460

acaaatgtgc cacacccaga cacgcacaga atcagacact acaaacacct gccttggggg     8520

tgaagtgaag gcccagcctc cccaccccac cgcgccccag gggttggagg accttgtctg     8580

tgtcaggaca gtgtccctcc ctgggaatgt gacatgaggg ccgactgggg ccaggctcag     8640

gggcagaggc tgggacacaa ggggctggcg agggctgcga ggccagggaa gccctgagtt     8700

tctggcgggg ctgagcagtg ggggagcatt gtgttgtggg tgtctgtgtg tgaggtcacc     8760

ctcaaactgc accgccggcc agataccctc ctgaccccga ggacttggtc tggtctctct     8820

ggtggctaca accccagagt tttaaggact tggaaaggaa agcacaatca gagaagaaaa     8880

cagcccccga accagcagga gtggcctggc acatggaccg gcctgagcga tgtgcactcc     8940

acccaagcca ggctcccagg gggcctgatt tctctctcac tgtctctttt tttaaaatgg     9000

ttgcacggct ctgccccatg gggggccttt tttacacact gcgaggccca gctttctagg     9060

ggacttttgc acatgtcatg cagctcagct gggagctgct taggtggaaa actccaaata     9120

aagtgcggct gtcgcagaaa aaaaaaaaa                                       9149


<210> 400
<211> 2725
<212> PRT
<213> Homo sapiens

<400> 400
Met Met Asn Asn Ser Gly Tyr Ser Asp Ala Gly Leu Gly Leu Gly Asp 
1               5                   10                  15      


Glu Thr Asp Glu Met Pro Ser Thr Glu Lys Asp Leu Ala Glu Asp Ala 
            20                  25                  30          


Pro Trp Lys Lys Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu 
        35                  40                  45              


His Leu Lys Cys Val Gly Lys Arg Leu Thr Asp Leu Gln Arg Asp Leu 
    50                  55                  60                  


Ser Asp Gly Leu Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys 
65                  70                  75                  80  


Arg Met Tyr Arg Lys Phe His Pro Arg Pro Asn Phe Arg Gln Met Lys 
                85                  90                  95      


Leu Glu Asn Val Ser Val Ala Leu Glu Phe Leu Glu Arg Glu His Ile 
            100                 105                 110         


Lys Leu Val Ser Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys 
        115                 120                 125             


Leu Ile Leu Gly Leu Ile Trp Thr Leu Ile Leu His Tyr Ser Ile Ser 
    130                 135                 140                 


Met Pro Met Trp Glu Asp Glu Asp Asp Glu Asp Ala Arg Lys Gln Thr 
145                 150                 155                 160 


Pro Lys Gln Arg Leu Leu Gly Trp Ile Gln Asn Lys Val Pro Gln Leu 
                165                 170                 175     


Pro Ile Thr Asn Phe Asn Arg Asp Trp Gln Asp Gly Lys Ala Leu Gly 
            180                 185                 190         


Ala Leu Val Asp Asn Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ala 
        195                 200                 205             


Trp Asp Pro Asn Gln Pro Val Glu Asn Ala Arg Glu Ala Met Gln Gln 
    210                 215                 220                 


Ala Asp Asp Trp Leu Gly Val Pro Gln Val Ile Ala Pro Glu Glu Ile 
225                 230                 235                 240 


Val Asp Pro Asn Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln 
                245                 250                 255     


Phe Pro Lys Ala Lys Leu Lys Pro Gly Ala Pro Val Arg Ser Lys Gln 
            260                 265                 270         


Leu Asn Pro Lys Lys Ala Ile Ala Tyr Gly Pro Gly Ile Glu Pro Gln 
        275                 280                 285             


Gly Asn Thr Val Leu Gln Pro Ala His Phe Thr Val Gln Thr Val Asp 
    290                 295                 300                 


Ala Gly Val Gly Glu Val Leu Val Tyr Ile Glu Asp Pro Glu Gly His 
305                 310                 315                 320 


Thr Glu Glu Ala Lys Val Val Pro Asn Asn Asp Lys Asp Arg Thr Tyr 
                325                 330                 335     


Ala Val Ser Tyr Val Pro Lys Val Ala Gly Leu His Lys Val Thr Val 
            340                 345                 350         


Leu Phe Ala Gly Gln Asn Ile Glu Arg Ser Pro Phe Glu Val Asn Val 
        355                 360                 365             


Gly Met Ala Leu Gly Asp Ala Asn Lys Val Ser Ala Arg Gly Pro Gly 
    370                 375                 380                 


Leu Glu Pro Val Gly Asn Val Ala Asn Lys Pro Thr Tyr Phe Asp Ile 
385                 390                 395                 400 


Tyr Thr Ala Gly Ala Gly Thr Gly Asp Val Ala Val Val Ile Val Asp 
                405                 410                 415     


Pro Gln Gly Arg Arg Asp Thr Val Glu Val Ala Leu Glu Asp Lys Gly 
            420                 425                 430         


Asp Ser Thr Phe Arg Cys Thr Tyr Arg Pro Ala Met Glu Gly Pro His 
        435                 440                 445             


Thr Val His Val Ala Phe Ala Gly Ala Pro Ile Thr Arg Ser Pro Phe 
    450                 455                 460                 


Pro Val His Val Ser Glu Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser 
465                 470                 475                 480 


Gly Arg Gly Leu Gln Pro Lys Gly Val Arg Val Lys Glu Val Ala Asp 
                485                 490                 495     


Phe Lys Val Phe Thr Lys Gly Ala Gly Ser Gly Glu Leu Lys Val Thr 
            500                 505                 510         


Val Lys Gly Pro Lys Gly Thr Glu Glu Pro Val Lys Val Arg Glu Ala 
        515                 520                 525             


Gly Asp Gly Val Phe Glu Cys Glu Tyr Tyr Pro Val Val Pro Gly Lys 
    530                 535                 540                 


Tyr Val Val Thr Ile Thr Trp Gly Gly Tyr Ala Ile Pro Arg Ser Pro 
545                 550                 555                 560 


Phe Glu Val Gln Val Ser Pro Glu Ala Gly Val Gln Lys Val Arg Ala 
                565                 570                 575     


Trp Gly Pro Gly Leu Glu Thr Gly Gln Val Gly Lys Ser Ala Asp Phe 
            580                 585                 590         


Val Val Glu Ala Ile Gly Thr Glu Val Gly Thr Leu Gly Phe Ser Ile 
        595                 600                 605             


Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp Asp Lys Gly Asp Gly 
    610                 615                 620                 


Ser Cys Asp Val Arg Tyr Trp Pro Thr Glu Pro Gly Glu Tyr Ala Val 
625                 630                 635                 640 


His Val Ile Cys Asp Asp Glu Asp Ile Arg Asp Ser Pro Phe Ile Ala 
                645                 650                 655     


His Ile Leu Pro Ala Pro Pro Asp Cys Phe Pro Asp Lys Val Lys Ala 
            660                 665                 670         


Phe Gly Pro Gly Leu Glu Pro Thr Gly Cys Ile Val Asp Lys Pro Ala 
        675                 680                 685             


Glu Phe Thr Ile Asp Ala Arg Ala Ala Gly Lys Gly Asp Leu Lys Leu 
    690                 695                 700                 


Tyr Ala Gln Asp Ala Asp Gly Cys Pro Ile Asp Ile Lys Val Ile Pro 
705                 710                 715                 720 


Asn Gly Asp Gly Thr Phe Arg Cys Ser Tyr Val Pro Thr Lys Pro Ile 
                725                 730                 735     


Lys His Thr Ile Ile Ile Ser Trp Gly Gly Val Asn Val Pro Lys Ser 
            740                 745                 750         


Pro Phe Arg Val Asn Val Gly Glu Gly Ser His Pro Glu Arg Val Lys 
        755                 760                 765             


Val Tyr Gly Pro Gly Val Glu Lys Thr Gly Leu Lys Ala Asn Glu Pro 
    770                 775                 780                 


Thr Tyr Phe Thr Val Asp Cys Ser Glu Ala Gly Gln Gly Asp Val Ser 
785                 790                 795                 800 


Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly Pro Ala Glu Ala Asp 
                805                 810                 815     


Ile Asp Phe Asp Ile Ile Lys Asn Asp Asn Asp Thr Phe Thr Val Lys 
            820                 825                 830         


Tyr Thr Pro Pro Gly Ala Gly Arg Tyr Thr Ile Met Val Leu Phe Ala 
        835                 840                 845             


Asn Gln Glu Ile Pro Ala Ser Pro Phe His Ile Lys Val Asp Pro Ser 
    850                 855                 860                 


His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro Gly Leu Asn Arg Thr 
865                 870                 875                 880 


Gly Val Glu Val Gly Lys Pro Thr His Phe Thr Val Leu Thr Lys Gly 
                885                 890                 895     


Ala Gly Lys Ala Lys Leu Asp Val Gln Phe Ala Gly Thr Ala Lys Gly 
            900                 905                 910         


Glu Val Val Arg Asp Phe Glu Ile Ile Asp Asn His Asp Tyr Ser Tyr 
        915                 920                 925             


Thr Val Lys Tyr Thr Ala Val Gln Gln Gly Asn Met Ala Val Thr Val 
    930                 935                 940                 


Thr Tyr Gly Gly Asp Pro Val Pro Lys Ser Pro Phe Val Val Asn Val 
945                 950                 955                 960 


Ala Pro Pro Leu Asp Leu Ser Lys Ile Lys Val Gln Gly Leu Asn Ser 
                965                 970                 975     


Lys Val Ala Val Gly Gln Glu Gln Ala Phe Ser Val Asn Thr Arg Gly 
            980                 985                 990         


Ala Gly Gly Gln Gly Gln Leu Asp  Val Arg Met Thr Ser  Pro Ser Arg 
        995                 1000                 1005             


Arg Pro  Ile Pro Cys Lys Leu  Glu Pro Gly Gly Gly  Ala Glu Ala 
    1010                 1015                 1020             


Gln Ala  Val Arg Tyr Met Pro  Pro Glu Glu Gly Pro  Tyr Lys Val 
    1025                 1030                 1035             


Asp Ile  Thr Tyr Asp Gly His  Pro Val Pro Gly Ser  Pro Phe Ala 
    1040                 1045                 1050             


Val Glu  Gly Val Leu Pro Pro  Asp Pro Ser Lys Val  Cys Ala Tyr 
    1055                 1060                 1065             


Gly Pro  Gly Leu Lys Gly Gly  Leu Val Gly Thr Pro  Ala Pro Phe 
    1070                 1075                 1080             


Ser Ile  Asp Thr Lys Gly Ala  Gly Thr Gly Gly Leu  Gly Leu Thr 
    1085                 1090                 1095             


Val Glu  Gly Pro Cys Glu Ala  Lys Ile Glu Cys Gln  Asp Asn Gly 
    1100                 1105                 1110             


Asp Gly  Ser Cys Ala Val Ser  Tyr Leu Pro Thr Glu  Pro Gly Glu 
    1115                 1120                 1125             


Tyr Thr  Ile Asn Ile Leu Phe  Ala Glu Ala His Ile  Pro Gly Ser 
    1130                 1135                 1140             


Pro Phe  Lys Ala Thr Ile Arg  Pro Val Phe Asp Pro  Ser Lys Val 
    1145                 1150                 1155             


Arg Ala  Ser Gly Pro Gly Leu  Glu Arg Gly Lys Val  Gly Glu Ala 
    1160                 1165                 1170             


Ala Thr  Phe Thr Val Asp Cys  Ser Glu Ala Gly Glu  Ala Glu Leu 
    1175                 1180                 1185             


Thr Ile  Glu Ile Leu Ser Asp  Ala Gly Val Lys Ala  Glu Val Leu 
    1190                 1195                 1200             


Ile His  Asn Asn Ala Asp Gly  Thr Tyr His Ile Thr  Tyr Ser Pro 
    1205                 1210                 1215             


Ala Phe  Pro Gly Thr Tyr Thr  Ile Thr Ile Lys Tyr  Gly Gly His 
    1220                 1225                 1230             


Pro Val  Pro Lys Phe Pro Thr  Arg Val His Val Gln  Pro Ala Val 
    1235                 1240                 1245             


Asp Thr  Ser Gly Val Lys Val  Ser Gly Pro Gly Val  Glu Pro His 
    1250                 1255                 1260             


Gly Val  Leu Arg Glu Val Thr  Thr Glu Phe Thr Val  Asp Ala Arg 
    1265                 1270                 1275             


Ser Leu  Thr Ala Thr Gly Gly  Asn His Val Thr Ala  Arg Val Leu 
    1280                 1285                 1290             


Asn Pro  Ser Gly Ala Lys Thr  Asp Thr Tyr Val Thr  Asp Asn Gly 
    1295                 1300                 1305             


Asp Gly  Thr Tyr Arg Val Gln  Tyr Thr Ala Tyr Glu  Glu Gly Val 
    1310                 1315                 1320             


His Leu  Val Glu Val Leu Tyr  Asp Glu Val Ala Val  Pro Lys Ser 
    1325                 1330                 1335             


Pro Phe  Arg Val Gly Val Thr  Glu Gly Cys Asp Pro  Thr Arg Val 
    1340                 1345                 1350             


Arg Ala  Phe Gly Pro Gly Leu  Glu Gly Gly Leu Val  Asn Lys Ala 
    1355                 1360                 1365             


Asn Arg  Phe Thr Val Glu Thr  Arg Gly Ala Gly Thr  Gly Gly Leu 
    1370                 1375                 1380             


Gly Leu  Ala Ile Glu Gly Pro  Ser Glu Ala Lys Met  Ser Cys Lys 
    1385                 1390                 1395             


Asp Asn  Lys Asp Gly Ser Cys  Thr Val Glu Tyr Ile  Pro Phe Thr 
    1400                 1405                 1410             


Pro Gly  Asp Tyr Asp Val Asn  Ile Thr Phe Gly Gly  Arg Pro Ile 
    1415                 1420                 1425             


Pro Gly  Ser Pro Phe Arg Val  Pro Val Lys Asp Val  Val Asp Pro 
    1430                 1435                 1440             


Gly Lys  Val Lys Cys Ser Gly  Pro Gly Leu Gly Ala  Gly Val Arg 
    1445                 1450                 1455             


Ala Arg  Val Pro Gln Thr Phe  Thr Val Asp Cys Ser  Gln Ala Gly 
    1460                 1465                 1470             


Arg Ala  Pro Leu Gln Val Ala  Val Leu Gly Pro Thr  Gly Val Ala 
    1475                 1480                 1485             


Glu Pro  Val Glu Val Arg Asp  Asn Gly Asp Gly Thr  His Thr Val 
    1490                 1495                 1500             


His Tyr  Thr Pro Ala Thr Asp  Gly Pro Tyr Thr Val  Ala Val Lys 
    1505                 1510                 1515             


Tyr Ala  Asp Gln Glu Val Pro  Arg Ser Pro Phe Lys  Ile Lys Val 
    1520                 1525                 1530             


Leu Pro  Ala His Asp Ala Ser  Lys Val Arg Ala Ser  Gly Pro Gly 
    1535                 1540                 1545             


Leu Asn  Ala Ser Gly Ile Pro  Ala Ser Leu Pro Val  Glu Phe Thr 
    1550                 1555                 1560             


Ile Asp  Ala Arg Asp Ala Gly  Glu Gly Leu Leu Thr  Val Gln Ile 
    1565                 1570                 1575             


Leu Asp  Pro Glu Gly Lys Pro  Lys Lys Ala Asn Ile  Arg Asp Asn 
    1580                 1585                 1590             


Gly Asp  Gly Thr Tyr Thr Val  Ser Tyr Leu Pro Asp  Met Ser Gly 
    1595                 1600                 1605             


Arg Tyr  Thr Ile Thr Ile Lys  Tyr Gly Gly Asp Glu  Ile Pro Tyr 
    1610                 1615                 1620             


Ser Pro  Phe Arg Ile His Ala  Leu Pro Thr Gly Asp  Ala Ser Lys 
    1625                 1630                 1635             


Cys Leu  Val Thr Val Ser Ile  Gly Gly His Gly Leu  Gly Ala Cys 
    1640                 1645                 1650             


Leu Gly  Pro Arg Ile Gln Ile  Gly Gln Glu Thr Val  Ile Thr Val 
    1655                 1660                 1665             


Asp Ala  Lys Ala Ala Gly Glu  Gly Lys Val Thr Cys  Thr Val Ser 
    1670                 1675                 1680             


Thr Pro  Asp Gly Ala Glu Leu  Asp Val Asp Val Val  Glu Asn His 
    1685                 1690                 1695             


Asp Gly  Thr Phe Asp Ile Tyr  Tyr Thr Ala Pro Glu  Pro Gly Lys 
    1700                 1705                 1710             


Tyr Val  Ile Thr Ile Arg Phe  Gly Gly Glu His Ile  Pro Asn Ser 
    1715                 1720                 1725             


Pro Phe  His Val Leu Ala Cys  Asp Pro Leu Pro His  Glu Glu Glu 
    1730                 1735                 1740             


Pro Ser  Glu Val Pro Gln Leu  Arg Gln Pro Tyr Ala  Pro Pro Arg 
    1745                 1750                 1755             


Pro Gly  Ala Arg Pro Thr His  Trp Ala Thr Glu Glu  Pro Val Val 
    1760                 1765                 1770             


Pro Val  Glu Pro Met Glu Ser  Met Leu Arg Pro Phe  Asn Leu Val 
    1775                 1780                 1785             


Ile Pro  Phe Ala Val Gln Lys  Gly Glu Leu Thr Gly  Glu Val Arg 
    1790                 1795                 1800             


Met Pro  Ser Gly Lys Thr Ala  Arg Pro Asn Ile Thr  Asp Asn Lys 
    1805                 1810                 1815             


Asp Gly  Thr Ile Thr Val Arg  Tyr Ala Pro Thr Glu  Lys Gly Leu 
    1820                 1825                 1830             


His Gln  Met Gly Ile Lys Tyr  Asp Gly Asn His Ile  Pro Gly Ser 
    1835                 1840                 1845             


Pro Leu  Gln Phe Tyr Val Asp  Ala Ile Asn Ser Arg  His Val Ser 
    1850                 1855                 1860             


Ala Tyr  Gly Pro Gly Leu Ser  His Gly Met Val Asn  Lys Pro Ala 
    1865                 1870                 1875             


Thr Phe  Thr Ile Val Thr Lys  Asp Ala Gly Glu Gly  Gly Leu Ser 
    1880                 1885                 1890             


Leu Ala  Val Glu Gly Pro Ser  Lys Ala Glu Ile Thr  Cys Lys Asp 
    1895                 1900                 1905             


Asn Lys  Asp Gly Thr Cys Thr  Val Ser Tyr Leu Pro  Thr Ala Pro 
    1910                 1915                 1920             


Gly Asp  Tyr Ser Ile Ile Val  Arg Phe Asp Asp Lys  His Ile Pro 
    1925                 1930                 1935             


Gly Ser  Pro Phe Thr Ala Lys  Ile Thr Gly Asp Asp  Ser Met Arg 
    1940                 1945                 1950             


Thr Ser  Gln Leu Asn Val Gly  Thr Ser Thr Asp Val  Ser Leu Lys 
    1955                 1960                 1965             


Ile Thr  Glu Ser Asp Leu Ser  Gln Leu Thr Ala Ser  Ile Arg Ala 
    1970                 1975                 1980             


Pro Ser  Gly Asn Glu Glu Pro  Cys Leu Leu Lys Arg  Leu Pro Asn 
    1985                 1990                 1995             


Arg His  Ile Gly Ile Ser Phe  Thr Pro Lys Glu Val  Gly Glu His 
    2000                 2005                 2010             


Val Val  Ser Val Arg Lys Ser  Gly Lys His Val Thr  Asn Ser Pro 
    2015                 2020                 2025             


Phe Lys  Ile Leu Val Gly Pro  Ser Glu Ile Gly Asp  Ala Ser Lys 
    2030                 2035                 2040             


Val Arg  Val Trp Gly Lys Gly  Leu Ser Glu Gly His  Thr Phe Gln 
    2045                 2050                 2055             


Val Ala  Glu Phe Ile Val Asp  Thr Arg Asn Ala Gly  Tyr Gly Gly 
    2060                 2065                 2070             


Leu Gly  Leu Ser Ile Glu Gly  Pro Ser Lys Val Asp  Ile Asn Cys 
    2075                 2080                 2085             


Glu Asp  Met Glu Asp Gly Thr  Cys Lys Val Thr Tyr  Cys Pro Thr 
    2090                 2095                 2100             


Glu Pro  Gly Thr Tyr Ile Ile  Asn Ile Lys Phe Ala  Asp Lys His 
    2105                 2110                 2115             


Val Pro  Gly Ser Pro Phe Thr  Val Lys Val Thr Gly  Glu Gly Arg 
    2120                 2125                 2130             


Met Lys  Glu Ser Ile Thr Arg  Arg Arg Gln Ala Pro  Ser Ile Ala 
    2135                 2140                 2145             


Thr Ile  Gly Ser Thr Cys Asp  Leu Asn Leu Lys Ile  Pro Gly Asn 
    2150                 2155                 2160             


Trp Phe  Gln Met Val Ser Ala  Gln Glu Arg Leu Thr  Arg Thr Phe 
    2165                 2170                 2175             


Thr Arg  Ser Ser His Thr Tyr  Thr Arg Thr Glu Arg  Thr Glu Ile 
    2180                 2185                 2190             


Ser Lys  Thr Arg Gly Gly Glu  Thr Lys Arg Glu Val  Arg Val Glu 
    2195                 2200                 2205             


Glu Ser  Thr Gln Val Gly Gly  Asp Pro Phe Pro Ala  Val Phe Gly 
    2210                 2215                 2220             


Asp Phe  Leu Gly Arg Glu Arg  Leu Gly Ser Phe Gly  Ser Ile Thr 
    2225                 2230                 2235             


Arg Gln  Gln Glu Gly Glu Ala  Ser Ser Gln Asp Met  Thr Ala Gln 
    2240                 2245                 2250             


Val Thr  Ser Pro Ser Gly Lys  Val Glu Ala Ala Glu  Ile Val Glu 
    2255                 2260                 2265             


Gly Glu  Asp Ser Ala Tyr Ser  Val Arg Phe Val Pro  Gln Glu Met 
    2270                 2275                 2280             


Gly Pro  His Thr Val Ala Val  Lys Tyr Arg Gly Gln  His Val Pro 
    2285                 2290                 2295             


Gly Ser  Pro Phe Gln Phe Thr  Val Gly Pro Leu Gly  Glu Gly Gly 
    2300                 2305                 2310             


Ala His  Lys Val Arg Ala Gly  Gly Thr Gly Leu Glu  Arg Gly Val 
    2315                 2320                 2325             


Ala Gly  Val Pro Ala Glu Phe  Ser Ile Trp Thr Arg  Glu Ala Gly 
    2330                 2335                 2340             


Ala Gly  Gly Leu Ser Ile Ala  Val Glu Gly Pro Ser  Lys Ala Glu 
    2345                 2350                 2355             


Ile Ala  Phe Glu Asp Arg Lys  Asp Gly Ser Cys Gly  Val Ser Tyr 
    2360                 2365                 2370             


Val Val  Gln Glu Pro Gly Asp  Tyr Glu Val Ser Ile  Lys Phe Asn 
    2375                 2380                 2385             


Asp Glu  His Ile Pro Asp Ser  Pro Phe Val Val Pro  Val Ala Ser 
    2390                 2395                 2400             


Leu Ser  Asp Asp Ala Arg Arg  Leu Thr Val Thr Ser  Leu Gln Glu 
    2405                 2410                 2415             


Thr Gly  Leu Lys Val Asn Gln  Pro Ala Ser Phe Ala  Val Gln Leu 
    2420                 2425                 2430             


Asn Gly  Ala Arg Gly Val Ile  Asp Ala Arg Val His  Thr Pro Ser 
    2435                 2440                 2445             


Gly Ala  Val Glu Glu Cys Tyr  Val Ser Glu Leu Asp  Ser Asp Lys 
    2450                 2455                 2460             


His Thr  Ile Arg Phe Ile Pro  His Glu Asn Gly Val  His Ser Ile 
    2465                 2470                 2475             


Asp Val  Lys Phe Asn Gly Ala  His Ile Pro Gly Ser  Pro Phe Lys 
    2480                 2485                 2490             


Ile Arg  Val Gly Glu Gln Ser  Gln Ala Gly Asp Pro  Gly Leu Val 
    2495                 2500                 2505             


Ser Ala  Tyr Gly Pro Gly Leu  Glu Gly Gly Thr Thr  Gly Val Ser 
    2510                 2515                 2520             


Ser Glu  Phe Ile Val Asn Thr  Leu Asn Ala Gly Ser  Gly Ala Leu 
    2525                 2530                 2535             


Ser Val  Thr Ile Asp Gly Pro  Ser Lys Val Gln Leu  Asp Cys Arg 
    2540                 2545                 2550             


Glu Cys  Pro Glu Gly His Val  Val Thr Tyr Thr Pro  Met Ala Pro 
    2555                 2560                 2565             


Gly Asn  Tyr Leu Ile Ala Ile  Lys Tyr Gly Gly Pro  Gln His Ile 
    2570                 2575                 2580             


Val Gly  Ser Pro Phe Lys Ala  Lys Val Thr Gly Pro  Arg Leu Ser 
    2585                 2590                 2595             


Gly Gly  His Ser Leu His Glu  Thr Ser Thr Val Leu  Val Glu Thr 
    2600                 2605                 2610             


Val Thr  Lys Ser Ser Ser Ser  Arg Gly Ser Ser Tyr  Ser Ser Ile 
    2615                 2620                 2625             


Pro Lys  Phe Ser Ser Asp Ala  Ser Lys Val Val Thr  Arg Gly Pro 
    2630                 2635                 2640             


Gly Leu  Ser Gln Ala Phe Val  Gly Gln Lys Asn Ser  Phe Thr Val 
    2645                 2650                 2655             


Asp Cys  Ser Lys Ala Gly Thr  Asn Met Met Met Val  Gly Val His 
    2660                 2665                 2670             


Gly Pro  Lys Thr Pro Cys Glu  Glu Val Tyr Val Lys  His Met Gly 
    2675                 2680                 2685             


Asn Arg  Val Tyr Asn Val Thr  Tyr Thr Val Lys Glu  Lys Gly Asp 
    2690                 2695                 2700             


Tyr Ile  Leu Ile Val Lys Trp  Gly Asp Glu Ser Val  Pro Gly Ser 
    2705                 2710                 2715             


Pro Phe  Lys Val Lys Val Pro  
    2720                 2725 


<210> 401
<211> 1635
<212> DNA
<213> Homo sapiens

<400> 401
aactctatat agggagttca actggtcacc cagagctgtc ctgtggcctc tgcagctcag       60

catggctagg gtactgggag cacccgttgc actggggttg tggagcctat gctggtctct      120

ggccattgcc acccctcttc ctccgactag tgcccatggg aatgttgctg aaggcgagac      180

caagccagac ccagacgtga ctgaacgctg ctcagatggc tggagctttg atgctaccac      240

cctggatgac aatggaacca tgctgttttt taaaggggag tttgtgtgga agagtcacaa      300

atgggaccgg gagttaatct cagagagatg gaagaatttc cccagccctg tggatgctgc      360

attccgtcaa ggtcacaaca gtgtctttct gatcaagggg gacaaagtct gggtataccc      420

tcctgaaaag aaggagaaag gatacccaaa gttgctccaa gatgaatttc ctggaatccc      480

atccccactg gatgcagctg tggaatgtca ccgtggagaa tgtcaagctg aaggcgtcct      540

cttcttccaa ggtgaccgcg agtggttctg ggacttggct acgggaacca tgaaggagcg      600

ttcctggcca gctgttggga actgctcctc tgccctgaga tggctgggcc gctactactg      660

cttccagggt aaccaattcc tgcgcttcga ccctgtcagg ggagaggtgc ctcccaggta      720

cccgcgggat gtccgagact acttcatgcc ctgccctggc agaggccatg gacacaggaa      780

tgggactggc catgggaaca gtacccacca tggccctgag tatatgcgct gtagcccaca      840

tctagtcttg tctgcactga cgtctgacaa ccatggtgcc acctatgcct tcagtgggac      900

ccactactgg cgtctggaca ccagccggga tggctggcat agctggccca ttgctcatca      960

gtggccccag ggtccttcag cagtggatgc tgccttttcc tgggaagaaa aactctatct     1020

ggtccagggc acccaggtat atgtcttcct gacaaaggga ggctataccc tagtaagcgg     1080

ttatccgaag cggctggaga aggaagtcgg gacccctcat gggattatcc tggactctgt     1140

ggatgcggcc tttatctgcc ctgggtcttc tcggctccat atcatggcag gacggcggct     1200

gtggtggctg gacctgaagt caggagccca agccacgtgg acagagcttc cttggcccca     1260

tgagaaggta gacggagcct tgtgtatgga aaagtccctt ggccctaact catgttccgc     1320

caatggtccc ggcttgtacc tcatccatgg tcccaatttg tactgctaca gtgatgtgga     1380

gaaactgaat gcagccaagg cccttccgca accccagaat gtgaccagtc tcctgggctg     1440

cactcactga ggggccttct gacatgagtc tggcctggcc ccacctccta gttcctcata     1500

ataaagacag attgcttctt cgcttctcac tgaggggcct tctgacatga gtctggcctg     1560

gccccacctc cccagtttct cataataaag acagattgct tcttcacttg aatcaaggga     1620

cctaaaaaaa aaaaa                                                      1635


<210> 402
<211> 462
<212> PRT
<213> Homo sapiens

<400> 402
Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                245                 250                 255     


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            260                 265                 270         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        275                 280                 285             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    290                 295                 300                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
305                 310                 315                 320 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                325                 330                 335     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            340                 345                 350         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        355                 360                 365             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    370                 375                 380                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
385                 390                 395                 400 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                405                 410                 415     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            420                 425                 430         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        435                 440                 445             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    450                 455                 460         


<210> 403
<211> 8434
<212> DNA
<213> Homo sapiens

<400> 403
ggaagagttc tagcctgaaa gggaactcgg gcgtcgtcct ggcgtcctct ccggattgcg       60

ccgcaccctc gcttcctgcc agggaggggc tgccgggctt tggcggctcc cgagcatcga      120

gaacggggcc agagcagctt cctgcctgcc ccccgcgacc atagagcgcg ggcccagggc      180

gccgcccgcg ggtgggggac gttcccagga cggaagtggc cgagagagtg tcgaagggag      240

ggcgaggccg gagcccgagg gcgacccgag aagcggcggg gcggcgggcc ggcgggcggg      300

gcgcagagcc aggcagcgca ggtatagcca ggctggagaa aagaagctgc caccatggtt      360

gcactttcac tgaagatcag cattgggaat gtggtgaaga cgatgcagtt tgagccgtct      420

accatggtgt acgacgcctg ccgcatcatt cgtgagcgga tcccagaggc cccagctggt      480

cctcccagcg actttgggct ctttctgtca gatgatgacc ccaaaaaggg tatatggctg      540

gaggctggga aagctttgga ctactacatg ctccgaaatg gggacactat ggagtacagg      600

aagaaacaga gacccctgaa gatccgtatg ctggatggaa ctgtgaagac gatcatggtg      660

gatgactcta agactgtcac tgacatgctc atgaccatct gtgcccgcat tggcatcacc      720

aatcatgatg aatattcatt ggttcgagag ctgatggaag agaaaaagga ggaaataaca      780

gggaccttaa gaaaggacaa gacattgctg cgagatgaaa agaagatgga gaaactaaag      840

cagaaattgc acacagatga tgagttgaac tggctggacc atggtcggac actgagggag      900

cagggtgtag aggagcacga gacgctgctg ctgcggagga agttctttta ctcagaccag      960

aatgtggatt cccgggaccc tgtacagctg aacctcctgt atgtgcaggc acgagatgac     1020

atcctgaatg gctcccaccc tgtctccttt gacaaggcct gtgagtttgc tggcttccaa     1080

tgccagatcc agtttgggcc ccacaatgag cagaagcaca aggctggctt ccttgacctg     1140

aaggacttcc tgcccaagga gtatgtgaag cagaagggag agcgtaagat cttccaggca     1200

cacaagaatt gtgggcagat gagtgagatt gaggccaagg tccgctacgt gaagctagcc     1260

cgttctctca agacttacgg tgtctccttc ttcctggtga aggaaaaaat gaaagggaag     1320

aacaagctag tgcccaggct tctgggcatc accaaggagt gtgtgatgcg agtggatgag     1380

aagaccaagg aagtgatcca ggagtggaac ctcaccaaca tcaaacgctg ggctgcgtct     1440

cccaaaagct tcaccctgga ttttggagat taccaagatg gctattactc agtacagaca     1500

actgaagggg agcagattgc acagctcatt gccggctaca tcgatatcat cctgaagaag     1560

aaaaaaagca aggatcactt tgggctggaa ggagatgagg agtctactat gctggaggac     1620

tcagtgtccc ccaaaaagtc aacagtcctg cagcagcaat acaaccgggt ggggaaagtg     1680

gagcatggct ctgtggccct gcctgccatc atgcgctctg gagcctctgg tcctgagaat     1740

ttccaggtgg gcagcatgcc ccctgcccag cagcagatta ccagcggcca gatgcaccga     1800

ggacacatgc ctcctctgac ttcagcccag caggcactca ctggaaccat taactccagc     1860

atgcaggccg tgcaggctgc ccaggccacc ctggatgact ttgacactct gccgcctctt     1920

ggccaggatg ctgcctctaa ggcctggcgt aaaaacaaga tggatgaatc aaagcatgag     1980

atccactctc aggtagatgc catcacagct ggtactgcgt ctgtggtgaa cctgacagca     2040

ggggaccctg ctgagacaga ctataccgca gtgggctgtg cagtcaccac aatctcctcc     2100

aacctgacgg agatgtcccg tggggtgaag ctgctggctg ccttgctgga ggacgaaggc     2160

ggcagtggtc ggcccctgtt gcaggcagca aagggccttg cgggagcagt gtcagaactg     2220

ctgcgcagtg cccaaccagc cagtgctgag ccccgtcaga acctgctgca agcagctggg     2280

aacgtgggcc aggccagtgg ggagctgttg caacaaattg gggaaagtga tactgacccc     2340

cacttccagg atgcgctaat gcagctcgcc aaagctgtgg caagtgctgc agctgccctg     2400

gtcctcaagg ccaagagtgt ggcccagcgg acagaggact cgggacttca gacccaagtt     2460

attgctgcag caacacagtg tgccctatcc acttcccaac tagtggcctg tactaaggtg     2520

gtggcaccta caatcagctc acctgtctgc caagagcaac tggtggaggc tggacgactg     2580

gtagccaaag ccgtggaggg ctgtgtgtct gcctcccagg cagctacaga ggatgggcaa     2640

ctgttgcgag gggtaggagc agcagccaca gctgtcaccc aggccctaaa tgagctgctg     2700

cagcatgtga aagcccatgc cacaggggct gggcctgctg gccgttatga ccaggctact     2760

gacaccatcc taaccgtcac tgagaacatc tttagctcca tgggtgatgc tggggagatg     2820

gtgcgacagg cccgcatcct ggcccaagcc acatctgacc tggtcaatgc catcaaggct     2880

gatgctgagg gggaaagtga tctggagaac tcccgcaagc tcttaagtgc tgccaagatc     2940

ctagctgatg ccacagccaa gatggtagag gctgccaagg gagcagctgc ccaccctgac     3000

agtgaggagc agcagcagcg gctgcgggag gcagctgagg ggctgcgcat ggccaccaat     3060

gcagctgcgc agaatgccat caagaaaaag ctggtgcagc gcctggagca tgcagccaag     3120

caggctgcag cctcagccac acagaccatc gctgcagctc agcacgcagc ctctaccccc     3180

aaggcctctg ccggccccca gcccctgctg gtgcagagct gcaaggcagt ggcagagcag     3240

attccactgc tggtgcaggg cgtccgagga agccaagccc agcctgacag ccccagcgct     3300

cagcttgccc tcattgctgc cagccagagc ttcctgcagc caggtgggaa gatggtggca     3360

gctgcaaagg cctcagtgcc aacgattcag gaccaggctt cagccatgca gctgagtcag     3420

tgtgccaaga acctgggcac cgcgctggct gaactccgga cggctgccca gaaggctcag     3480

gaagcatgtg gacctttgga gatggattct gcactgagtg tggtacagaa tctagagaaa     3540

gatctacagg aagtgaaggc agcagctcga gatggcaagc ttaaaccctt acctggggag     3600

acaatggaga agtgtaccca ggacctgggc aacagcacca aagccgtgag ctcagccatc     3660

gcccagctac tgggagaggt tgcccagggc aatgagaatt atgcaggtat tgcagctcgg     3720

gatgtggcag gtgggctgcg gtcactggcc caggccgcta ggggagtcgc tgcactgacg     3780

tcagatcctg cagtgcaggc cattgtactt gatacggcca gtgatgtgct ggacaaggcc     3840

agcagcctca ttgaggaggc gaaaaaggca gctggccatc caggggaccc tgagagccag     3900

cagcggcttg cccaggtggc taaagcagtg acccaggctc tgaaccgctg tgtcagctgc     3960

ctacctggcc agcgcgatgt ggataatgcc ctgagggcag ttggagatgc cagcaagcga     4020

ctcctgagtg actcgcttcc tcctagcact gggacatttc aagaagctca gagccggttg     4080

aatgaagctg ctgctgggct gaatcaggca gccacagaac tggtgcaggc ctctcgggga     4140

acccctcagg acctggctcg agcctcaggc cgatttggac aggacttcag caccttcctg     4200

gaagctggtg tggagatggc aggccaggct ccgagccagg aggaccgagc ccaagttgtg     4260

tccaacttga agggcatctc catgtcttca agcaaacttc ttctggctgc caaggccctg     4320

tccacggacc ctgctgcccc taacctcaag agtcagctgg ctgcagctgc cagggcagta     4380

actgacagca tcaatcagct catcactatg tgcacccagc aggcacccgg ccagaaggag     4440

tgtgataacg ccctgcggga attggagacg gtccgggaac tcctggagaa cccagtccag     4500

cccatcaatg acatgtccta ctttggttgc ctggacagtg taatggagaa ctcaaaggtg     4560

ctgggcgagg ccatgactgg catctcccaa aatgccaaga acggaaacct gccagagttt     4620

ggagatgcca tttccacagc ctcaaaggca ctttgtggct tcaccgaggc agctgcacag     4680

gctgcatatc tggttggtgt ctctgacccc aatagccaag ctggacagca agggctagtg     4740

gagcccacac agtttgcccg tgcaaaccag gcaattcaga tggcctgcca gagtttggga     4800

gagcctggct gtacccaggc ccaggtgctc tctgcagcca ccattgtggc taaacacacc     4860

tctgcactgt gtaacagctg tcgcctggct tctgcccgta ccaccaatcc tactgccaag     4920

cgccagtttg tacagtcagc caaggaggtg gccaacagca cagctaatct tgtcaagacc     4980

atcaaggcgc tagatggggc cttcacagag gagaaccgtg cccagtgccg agcagcaaca     5040

gcccctctgc tggaggctgt ggacaatctg agtgcctttg cgtccaaccc tgagttctcc     5100

agcattcctg cccagatcag ccctgagggt cgggctgcca tggagcccat tgtgatctct     5160

gccaagacaa tgttagagag tgccggggga ctcatccaga cagcccgggc cctcgcagtc     5220

aatccccggg accccccgag ctggtcggtg ctggccggcc actcccgtac tgtctcagac     5280

tccatcaaga agctaattac aagcatgagg gacaaggctc cagggcagct ggagtgtgaa     5340

acggccattg cagctctgaa cagttgtcta cgggacctag accaggcttc cctcgctgca     5400

gtcagccagc agcttgctcc ccgtgaggga atctctcaag aggccttgca cactcagatg     5460

ctcactgcag tccaagagat ctcccatctc attgagccgc tggccaatgc tgcccgggct     5520

gaagcctccc agctgggaca caaggtgtcc cagatggcgc agtactttga gccgctcacc     5580

ctggctgcag tgggtgctgc ctccaagacc ctgagccacc cgcagcagat ggcactcctg     5640

gaccagacta aaacattggc agagtctgcc ctgcagttgc tatacactgc caaggaggct     5700

ggtggtaacc caaagcaagc agctcacacc caggaagccc tggaggaggc tgtgcagatg     5760

atgaccgagg ccgtagagga cctgacaaca accctcaacg aggcagccag tgctgctggg     5820

gtcgtgggtg gcatggtgga ctccatcacc caggccatca accagctaga tgaaggacca     5880

atgggtgaac cagaaggttc cttcgtggat taccaaacaa ctatggtgcg gacagccaag     5940

gccattgcag tgaccgttca ggagatggtt accaagtcaa acaccagccc agaggagctg     6000

ggccctcttg ctaaccagct gaccagtgac tatggccgtc tggcctcgga ggccaagcct     6060

gcagcggtgg ctgctgaaaa tgaagagata ggttcccata tcaaacaccg ggtacaggag     6120

ctgggccatg gctgtgccgc tctggtcacc aaggcaggcg ccctgcagtg cagccccagt     6180

gatgcctaca ccaagaagga gctcatagag tgtgcccgga gagtctctga gaaggtctcc     6240

cacgtcctgg ctgcgctcca ggctgggaat cgtggcaccc aggcctgcat cacagcagcc     6300

agcgctgtgt ctggtatcat tgctgacctc gacaccacca tcatgttcgc cactgctggc     6360

acgctcaatc gtgagggtac tgaaactttc gctgaccacc gggagggcat cctgaagact     6420

gcgaaggtgc tggtggagga caccaaggtc ctggtgcaaa acgcagctgg gagccaggag     6480

aagttggcgc aggctgccca gtcctccgtg gcgaccatca cccgcctcgc tgatgtggtc     6540

aagctgggtg cagccagcct gggagctgag gaccctgaga cccaggtggt actaatcaac     6600

gcagtgaaag atgtagccaa agccctggga gacctcatca gtgcaacgaa ggctgcagct     6660

ggcaaagttg gagatgaccc tgctgtgtgg cagctaaaga actctgccaa ggtgatggtg     6720

accaatgtga catcattgct taagacagta aaagccgtgg aagatgaggc caccaaaggc     6780

actcgggccc tggaggcaac cacagaacac atacggcagg agctggcggt tttctgttcc     6840

ccagagccac ctgccaagac ctctacccca gaagacttca tccgaatgac caagggtatc     6900

accatggcaa ccgccaaggc cgttgctgct ggcaattcct gtcgccagga agatgtcatt     6960

gccacagcca atctgagccg ccgtgctatt gcagatatgc ttcgggcttg caaggaagca     7020

gcttaccacc cagaagtggc ccctgatgtg cggcttcgag ccctgcacta tggccgggag     7080

tgtgccaatg gctacctgga actgctggac catgtactgc tgaccctgca gaagccaagc     7140

ccagaactga agcagcagtt gacaggacat tcaaagcgtg tggctggttc cgtcactgag     7200

ctcatccagg ctgctgaagc catgaaggga acagaatggg tagacccaga ggaccccaca     7260

gtcattgctg agaatgagct cctgggagct gcagccgcca ttgaggctgc agccaaaaag     7320

ctagagcagc tgaagccccg ggccaaaccc aaggaggcag atgagtcctt gaactttgag     7380

gagcagatac tagaagctgc caagtccatt gcagcagcca ccagtgcact ggtaaaggct     7440

gcgtcggctg cccagagaga actagtggcc caagggaagg tgggtgccat tccagccaat     7500

gcactggacg atgggcagtg gtcccagggc ctcatttctg ctgcccggat ggtggctgcg     7560

gccaccaaca atctgtgtga ggcagccaat gcagctgtac aaggccatgc cagccaggag     7620

aagctcatct catcagccaa gcaggtagct gcctccacag cccagctcct tgtggcctgc     7680

aaggtcaagg ctgaccagga ctcggaggca atgaaacgac ttcaggctgc tggcaacgca     7740

gtgaagcgag cctcagataa tctggtgaaa gcagcacaga aggctgcagc ctttgaagag     7800

caggagaatg agacagtggt ggtgaaagag aagatggttg gcggcattgc ccagatcatc     7860

gcagcacagg aagaaatgct tcggaaggaa cgagagctgg aagaggcgcg gaagaaactg     7920

gcccagatcc ggcagcagca gtacaagttt ctgccttcag agcttcgaga tgagcactaa     7980

agaagcctct tctatttaat gcagacccgg cccagagact gtgcgtgcca ctaccaaagc     8040

cttctgggct gtcggggccc aacctgccca accccagcac tccccaaagt gcctgccaaa     8100

ccccagggcc tggccccgcc cagtcccgca gtacatcccc tgtcccctcc ccaaccccaa     8160

gtgccttcat gccctagggc cccccaagtg cctgcccctc cccagagtat taacgctcca     8220

agagtattat taacgctgct gtacctcgat ctgaatctgc cggggcccca gcccactcca     8280

ccctgccagc agcttccggc cagtccccac agcctcatca gctctcttca ccgttttttg     8340

atactatctt cccccacccc cagctaccca taggggctgc agagttataa gccccaaaca     8400

ggtcatgctc caataaaaat gattctacct acaa                                 8434


<210> 404
<211> 2541
<212> PRT
<213> Homo sapiens

<400> 404
Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr 
1               5                   10                  15      


Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile 
            20                  25                  30          


Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly 
        35                  40                  45              


Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 
    50                  55                  60                  


Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 
65                  70                  75                  80  


Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr 
                85                  90                  95      


Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu 
            100                 105                 110         


Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser 
        115                 120                 125             


Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr 
    130                 135                 140                 


Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 
145                 150                 155                 160 


Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 
                165                 170                 175     


Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 
            180                 185                 190         


Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 
        195                 200                 205             


Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu 
    210                 215                 220                 


Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 
225                 230                 235                 240 


Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys 
                245                 250                 255     


Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys 
            260                 265                 270         


Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln 
        275                 280                 285             


Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 
    290                 295                 300                 


Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 
305                 310                 315                 320 


Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys 
                325                 330                 335     


Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn 
            340                 345                 350         


Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu 
        355                 360                 365             


Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu 
    370                 375                 380                 


Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu 
385                 390                 395                 400 


Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 
                405                 410                 415     


Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 
            420                 425                 430         


Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 
        435                 440                 445             


Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln 
    450                 455                 460                 


Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met 
465                 470                 475                 480 


His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr 
                485                 490                 495     


Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr 
            500                 505                 510         


Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser 
        515                 520                 525             


Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His 
    530                 535                 540                 


Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 
545                 550                 555                 560 


Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 
                565                 570                 575     


Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys 
            580                 585                 590         


Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu 
        595                 600                 605             


Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
    610                 615                 620                 


Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala 
625                 630                 635                 640 


Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 
                645                 650                 655     


Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala 
            660                 665                 670         


Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 
        675                 680                 685             


Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 
    690                 695                 700                 


Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr 
705                 710                 715                 720 


Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu 
                725                 730                 735     


Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser 
            740                 745                 750         


Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly 
        755                 760                 765             


Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His 
    770                 775                 780                 


Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 
785                 790                 795                 800 


Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 
                805                 810                 815     


Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala 
            820                 825                 830         


Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser 
        835                 840                 845             


Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala 
    850                 855                 860                 


Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 
865                 870                 875                 880 


Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly 
                885                 890                 895     


Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 
            900                 905                 910         


Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 
        915                 920                 925             


Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala 
    930                 935                 940                 


Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala 
945                 950                 955                 960 


Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln 
                965                 970                 975     


Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 
            980                 985                 990         


Phe Leu Gln Pro Gly Gly Lys Met  Val Ala Ala Ala Lys  Ala Ser Val 
        995                 1000                 1005             


Pro Thr  Ile Gln Asp Gln Ala  Ser Ala Met Gln Leu  Ser Gln Cys 
    1010                 1015                 1020             


Ala Lys  Asn Leu Gly Thr Ala  Leu Ala Glu Leu Arg  Thr Ala Ala 
    1025                 1030                 1035             


Gln Lys  Ala Gln Glu Ala Cys  Gly Pro Leu Glu Met  Asp Ser Ala 
    1040                 1045                 1050             


Leu Ser  Val Val Gln Asn Leu  Glu Lys Asp Leu Gln  Glu Val Lys 
    1055                 1060                 1065             


Ala Ala  Ala Arg Asp Gly Lys  Leu Lys Pro Leu Pro  Gly Glu Thr 
    1070                 1075                 1080             


Met Glu  Lys Cys Thr Gln Asp  Leu Gly Asn Ser Thr  Lys Ala Val 
    1085                 1090                 1095             


Ser Ser  Ala Ile Ala Gln Leu  Leu Gly Glu Val Ala  Gln Gly Asn 
    1100                 1105                 1110             


Glu Asn  Tyr Ala Gly Ile Ala  Ala Arg Asp Val Ala  Gly Gly Leu 
    1115                 1120                 1125             


Arg Ser  Leu Ala Gln Ala Ala  Arg Gly Val Ala Ala  Leu Thr Ser 
    1130                 1135                 1140             


Asp Pro  Ala Val Gln Ala Ile  Val Leu Asp Thr Ala  Ser Asp Val 
    1145                 1150                 1155             


Leu Asp  Lys Ala Ser Ser Leu  Ile Glu Glu Ala Lys  Lys Ala Ala 
    1160                 1165                 1170             


Gly His  Pro Gly Asp Pro Glu  Ser Gln Gln Arg Leu  Ala Gln Val 
    1175                 1180                 1185             


Ala Lys  Ala Val Thr Gln Ala  Leu Asn Arg Cys Val  Ser Cys Leu 
    1190                 1195                 1200             


Pro Gly  Gln Arg Asp Val Asp  Asn Ala Leu Arg Ala  Val Gly Asp 
    1205                 1210                 1215             


Ala Ser  Lys Arg Leu Leu Ser  Asp Ser Leu Pro Pro  Ser Thr Gly 
    1220                 1225                 1230             


Thr Phe  Gln Glu Ala Gln Ser  Arg Leu Asn Glu Ala  Ala Ala Gly 
    1235                 1240                 1245             


Leu Asn  Gln Ala Ala Thr Glu  Leu Val Gln Ala Ser  Arg Gly Thr 
    1250                 1255                 1260             


Pro Gln  Asp Leu Ala Arg Ala  Ser Gly Arg Phe Gly  Gln Asp Phe 
    1265                 1270                 1275             


Ser Thr  Phe Leu Glu Ala Gly  Val Glu Met Ala Gly  Gln Ala Pro 
    1280                 1285                 1290             


Ser Gln  Glu Asp Arg Ala Gln  Val Val Ser Asn Leu  Lys Gly Ile 
    1295                 1300                 1305             


Ser Met  Ser Ser Ser Lys Leu  Leu Leu Ala Ala Lys  Ala Leu Ser 
    1310                 1315                 1320             


Thr Asp  Pro Ala Ala Pro Asn  Leu Lys Ser Gln Leu  Ala Ala Ala 
    1325                 1330                 1335             


Ala Arg  Ala Val Thr Asp Ser  Ile Asn Gln Leu Ile  Thr Met Cys 
    1340                 1345                 1350             


Thr Gln  Gln Ala Pro Gly Gln  Lys Glu Cys Asp Asn  Ala Leu Arg 
    1355                 1360                 1365             


Glu Leu  Glu Thr Val Arg Glu  Leu Leu Glu Asn Pro  Val Gln Pro 
    1370                 1375                 1380             


Ile Asn  Asp Met Ser Tyr Phe  Gly Cys Leu Asp Ser  Val Met Glu 
    1385                 1390                 1395             


Asn Ser  Lys Val Leu Gly Glu  Ala Met Thr Gly Ile  Ser Gln Asn 
    1400                 1405                 1410             


Ala Lys  Asn Gly Asn Leu Pro  Glu Phe Gly Asp Ala  Ile Ser Thr 
    1415                 1420                 1425             


Ala Ser  Lys Ala Leu Cys Gly  Phe Thr Glu Ala Ala  Ala Gln Ala 
    1430                 1435                 1440             


Ala Tyr  Leu Val Gly Val Ser  Asp Pro Asn Ser Gln  Ala Gly Gln 
    1445                 1450                 1455             


Gln Gly  Leu Val Glu Pro Thr  Gln Phe Ala Arg Ala  Asn Gln Ala 
    1460                 1465                 1470             


Ile Gln  Met Ala Cys Gln Ser  Leu Gly Glu Pro Gly  Cys Thr Gln 
    1475                 1480                 1485             


Ala Gln  Val Leu Ser Ala Ala  Thr Ile Val Ala Lys  His Thr Ser 
    1490                 1495                 1500             


Ala Leu  Cys Asn Ser Cys Arg  Leu Ala Ser Ala Arg  Thr Thr Asn 
    1505                 1510                 1515             


Pro Thr  Ala Lys Arg Gln Phe  Val Gln Ser Ala Lys  Glu Val Ala 
    1520                 1525                 1530             


Asn Ser  Thr Ala Asn Leu Val  Lys Thr Ile Lys Ala  Leu Asp Gly 
    1535                 1540                 1545             


Ala Phe  Thr Glu Glu Asn Arg  Ala Gln Cys Arg Ala  Ala Thr Ala 
    1550                 1555                 1560             


Pro Leu  Leu Glu Ala Val Asp  Asn Leu Ser Ala Phe  Ala Ser Asn 
    1565                 1570                 1575             


Pro Glu  Phe Ser Ser Ile Pro  Ala Gln Ile Ser Pro  Glu Gly Arg 
    1580                 1585                 1590             


Ala Ala  Met Glu Pro Ile Val  Ile Ser Ala Lys Thr  Met Leu Glu 
    1595                 1600                 1605             


Ser Ala  Gly Gly Leu Ile Gln  Thr Ala Arg Ala Leu  Ala Val Asn 
    1610                 1615                 1620             


Pro Arg  Asp Pro Pro Ser Trp  Ser Val Leu Ala Gly  His Ser Arg 
    1625                 1630                 1635             


Thr Val  Ser Asp Ser Ile Lys  Lys Leu Ile Thr Ser  Met Arg Asp 
    1640                 1645                 1650             


Lys Ala  Pro Gly Gln Leu Glu  Cys Glu Thr Ala Ile  Ala Ala Leu 
    1655                 1660                 1665             


Asn Ser  Cys Leu Arg Asp Leu  Asp Gln Ala Ser Leu  Ala Ala Val 
    1670                 1675                 1680             


Ser Gln  Gln Leu Ala Pro Arg  Glu Gly Ile Ser Gln  Glu Ala Leu 
    1685                 1690                 1695             


His Thr  Gln Met Leu Thr Ala  Val Gln Glu Ile Ser  His Leu Ile 
    1700                 1705                 1710             


Glu Pro  Leu Ala Asn Ala Ala  Arg Ala Glu Ala Ser  Gln Leu Gly 
    1715                 1720                 1725             


His Lys  Val Ser Gln Met Ala  Gln Tyr Phe Glu Pro  Leu Thr Leu 
    1730                 1735                 1740             


Ala Ala  Val Gly Ala Ala Ser  Lys Thr Leu Ser His  Pro Gln Gln 
    1745                 1750                 1755             


Met Ala  Leu Leu Asp Gln Thr  Lys Thr Leu Ala Glu  Ser Ala Leu 
    1760                 1765                 1770             


Gln Leu  Leu Tyr Thr Ala Lys  Glu Ala Gly Gly Asn  Pro Lys Gln 
    1775                 1780                 1785             


Ala Ala  His Thr Gln Glu Ala  Leu Glu Glu Ala Val  Gln Met Met 
    1790                 1795                 1800             


Thr Glu  Ala Val Glu Asp Leu  Thr Thr Thr Leu Asn  Glu Ala Ala 
    1805                 1810                 1815             


Ser Ala  Ala Gly Val Val Gly  Gly Met Val Asp Ser  Ile Thr Gln 
    1820                 1825                 1830             


Ala Ile  Asn Gln Leu Asp Glu  Gly Pro Met Gly Glu  Pro Glu Gly 
    1835                 1840                 1845             


Ser Phe  Val Asp Tyr Gln Thr  Thr Met Val Arg Thr  Ala Lys Ala 
    1850                 1855                 1860             


Ile Ala  Val Thr Val Gln Glu  Met Val Thr Lys Ser  Asn Thr Ser 
    1865                 1870                 1875             


Pro Glu  Glu Leu Gly Pro Leu  Ala Asn Gln Leu Thr  Ser Asp Tyr 
    1880                 1885                 1890             


Gly Arg  Leu Ala Ser Glu Ala  Lys Pro Ala Ala Val  Ala Ala Glu 
    1895                 1900                 1905             


Asn Glu  Glu Ile Gly Ser His  Ile Lys His Arg Val  Gln Glu Leu 
    1910                 1915                 1920             


Gly His  Gly Cys Ala Ala Leu  Val Thr Lys Ala Gly  Ala Leu Gln 
    1925                 1930                 1935             


Cys Ser  Pro Ser Asp Ala Tyr  Thr Lys Lys Glu Leu  Ile Glu Cys 
    1940                 1945                 1950             


Ala Arg  Arg Val Ser Glu Lys  Val Ser His Val Leu  Ala Ala Leu 
    1955                 1960                 1965             


Gln Ala  Gly Asn Arg Gly Thr  Gln Ala Cys Ile Thr  Ala Ala Ser 
    1970                 1975                 1980             


Ala Val  Ser Gly Ile Ile Ala  Asp Leu Asp Thr Thr  Ile Met Phe 
    1985                 1990                 1995             


Ala Thr  Ala Gly Thr Leu Asn  Arg Glu Gly Thr Glu  Thr Phe Ala 
    2000                 2005                 2010             


Asp His  Arg Glu Gly Ile Leu  Lys Thr Ala Lys Val  Leu Val Glu 
    2015                 2020                 2025             


Asp Thr  Lys Val Leu Val Gln  Asn Ala Ala Gly Ser  Gln Glu Lys 
    2030                 2035                 2040             


Leu Ala  Gln Ala Ala Gln Ser  Ser Val Ala Thr Ile  Thr Arg Leu 
    2045                 2050                 2055             


Ala Asp  Val Val Lys Leu Gly  Ala Ala Ser Leu Gly  Ala Glu Asp 
    2060                 2065                 2070             


Pro Glu  Thr Gln Val Val Leu  Ile Asn Ala Val Lys  Asp Val Ala 
    2075                 2080                 2085             


Lys Ala  Leu Gly Asp Leu Ile  Ser Ala Thr Lys Ala  Ala Ala Gly 
    2090                 2095                 2100             


Lys Val  Gly Asp Asp Pro Ala  Val Trp Gln Leu Lys  Asn Ser Ala 
    2105                 2110                 2115             


Lys Val  Met Val Thr Asn Val  Thr Ser Leu Leu Lys  Thr Val Lys 
    2120                 2125                 2130             


Ala Val  Glu Asp Glu Ala Thr  Lys Gly Thr Arg Ala  Leu Glu Ala 
    2135                 2140                 2145             


Thr Thr  Glu His Ile Arg Gln  Glu Leu Ala Val Phe  Cys Ser Pro 
    2150                 2155                 2160             


Glu Pro  Pro Ala Lys Thr Ser  Thr Pro Glu Asp Phe  Ile Arg Met 
    2165                 2170                 2175             


Thr Lys  Gly Ile Thr Met Ala  Thr Ala Lys Ala Val  Ala Ala Gly 
    2180                 2185                 2190             


Asn Ser  Cys Arg Gln Glu Asp  Val Ile Ala Thr Ala  Asn Leu Ser 
    2195                 2200                 2205             


Arg Arg  Ala Ile Ala Asp Met  Leu Arg Ala Cys Lys  Glu Ala Ala 
    2210                 2215                 2220             


Tyr His  Pro Glu Val Ala Pro  Asp Val Arg Leu Arg  Ala Leu His 
    2225                 2230                 2235             


Tyr Gly  Arg Glu Cys Ala Asn  Gly Tyr Leu Glu Leu  Leu Asp His 
    2240                 2245                 2250             


Val Leu  Leu Thr Leu Gln Lys  Pro Ser Pro Glu Leu  Lys Gln Gln 
    2255                 2260                 2265             


Leu Thr  Gly His Ser Lys Arg  Val Ala Gly Ser Val  Thr Glu Leu 
    2270                 2275                 2280             


Ile Gln  Ala Ala Glu Ala Met  Lys Gly Thr Glu Trp  Val Asp Pro 
    2285                 2290                 2295             


Glu Asp  Pro Thr Val Ile Ala  Glu Asn Glu Leu Leu  Gly Ala Ala 
    2300                 2305                 2310             


Ala Ala  Ile Glu Ala Ala Ala  Lys Lys Leu Glu Gln  Leu Lys Pro 
    2315                 2320                 2325             


Arg Ala  Lys Pro Lys Glu Ala  Asp Glu Ser Leu Asn  Phe Glu Glu 
    2330                 2335                 2340             


Gln Ile  Leu Glu Ala Ala Lys  Ser Ile Ala Ala Ala  Thr Ser Ala 
    2345                 2350                 2355             


Leu Val  Lys Ala Ala Ser Ala  Ala Gln Arg Glu Leu  Val Ala Gln 
    2360                 2365                 2370             


Gly Lys  Val Gly Ala Ile Pro  Ala Asn Ala Leu Asp  Asp Gly Gln 
    2375                 2380                 2385             


Trp Ser  Gln Gly Leu Ile Ser  Ala Ala Arg Met Val  Ala Ala Ala 
    2390                 2395                 2400             


Thr Asn  Asn Leu Cys Glu Ala  Ala Asn Ala Ala Val  Gln Gly His 
    2405                 2410                 2415             


Ala Ser  Gln Glu Lys Leu Ile  Ser Ser Ala Lys Gln  Val Ala Ala 
    2420                 2425                 2430             


Ser Thr  Ala Gln Leu Leu Val  Ala Cys Lys Val Lys  Ala Asp Gln 
    2435                 2440                 2445             


Asp Ser  Glu Ala Met Lys Arg  Leu Gln Ala Ala Gly  Asn Ala Val 
    2450                 2455                 2460             


Lys Arg  Ala Ser Asp Asn Leu  Val Lys Ala Ala Gln  Lys Ala Ala 
    2465                 2470                 2475             


Ala Phe  Glu Glu Gln Glu Asn  Glu Thr Val Val Val  Lys Glu Lys 
    2480                 2485                 2490             


Met Val  Gly Gly Ile Ala Gln  Ile Ile Ala Ala Gln  Glu Glu Met 
    2495                 2500                 2505             


Leu Arg  Lys Glu Arg Glu Leu  Glu Glu Ala Arg Lys  Lys Leu Ala 
    2510                 2515                 2520             


Gln Ile  Arg Gln Gln Gln Tyr  Lys Phe Leu Pro Ser  Glu Leu Arg 
    2525                 2530                 2535             


Asp Glu  His 
    2540     


<210> 405
<211> 829
<212> DNA
<213> Homo sapiens

<400> 405
tggggagtga aagcgaaagc ccgggcgact agccgggaga ccagagatct agcgactgaa       60

gcagcatggc caagccgtgt ggggtgcgcc tgagcgggga agcccgcaaa caggtggagg      120

tcttcagaca gaatcttttc caggaggctg aggaattcct ctacagattc ttgccacaga      180

aaatcatata cctgaatcag ctcttgcaag aggactccct caatgtggct gacttgactt      240

ccctccgggc cccactggac atccccatcc cagaccctcc acccaaggat gatgagatgg      300

aaacagataa gcaggagaag aaagaagtcc ataagtgtgg atttctccct gggaatgaga      360

aagtcctgtc cctgcttgcc ctggttaagc cagaagtctg gactctcaaa gagaaatgca      420

ttctggtgat tacatggatc caacacctga tccccaagat tgaagatgga aatgattttg      480

gggtagcaat ccaggagaag gtgctggaga gggtgaatgc cgtcaagacc aaagtggaag      540

ctttccagac aaccatttcc aagtacttct cagaacgtgg ggatgctgtg gccaaggcct      600

ccaaggagac tcatgtaatg gattaccggg ccttggtgca tgagcgagat gaggcagcct      660

atggggagct cagggccatg gtgctggacc tgagggcctt ctatgctgag ctttatcata      720

tcatcagcag caacctggag aaaattgtca acccaaaggg tgaagaaaag ccatctatgt      780

actgaacccg ggactagaag gaaaataaat gatctatatg ttgtgtgga                  829


<210> 406
<211> 239
<212> PRT
<213> Homo sapiens

<400> 406
Met Ala Lys Pro Cys Gly Val Arg Leu Ser Gly Glu Ala Arg Lys Gln 
1               5                   10                  15      


Val Glu Val Phe Arg Gln Asn Leu Phe Gln Glu Ala Glu Glu Phe Leu 
            20                  25                  30          


Tyr Arg Phe Leu Pro Gln Lys Ile Ile Tyr Leu Asn Gln Leu Leu Gln 
        35                  40                  45              


Glu Asp Ser Leu Asn Val Ala Asp Leu Thr Ser Leu Arg Ala Pro Leu 
    50                  55                  60                  


Asp Ile Pro Ile Pro Asp Pro Pro Pro Lys Asp Asp Glu Met Glu Thr 
65                  70                  75                  80  


Asp Lys Gln Glu Lys Lys Glu Val His Lys Cys Gly Phe Leu Pro Gly 
                85                  90                  95      


Asn Glu Lys Val Leu Ser Leu Leu Ala Leu Val Lys Pro Glu Val Trp 
            100                 105                 110         


Thr Leu Lys Glu Lys Cys Ile Leu Val Ile Thr Trp Ile Gln His Leu 
        115                 120                 125             


Ile Pro Lys Ile Glu Asp Gly Asn Asp Phe Gly Val Ala Ile Gln Glu 
    130                 135                 140                 


Lys Val Leu Glu Arg Val Asn Ala Val Lys Thr Lys Val Glu Ala Phe 
145                 150                 155                 160 


Gln Thr Thr Ile Ser Lys Tyr Phe Ser Glu Arg Gly Asp Ala Val Ala 
                165                 170                 175     


Lys Ala Ser Lys Glu Thr His Val Met Asp Tyr Arg Ala Leu Val His 
            180                 185                 190         


Glu Arg Asp Glu Ala Ala Tyr Gly Glu Leu Arg Ala Met Val Leu Asp 
        195                 200                 205             


Leu Arg Ala Phe Tyr Ala Glu Leu Tyr His Ile Ile Ser Ser Asn Leu 
    210                 215                 220                 


Glu Lys Ile Val Asn Pro Lys Gly Glu Glu Lys Pro Ser Met Tyr 
225                 230                 235                 


<210> 407
<211> 2545
<212> DNA
<213> Homo sapiens

<400> 407
gtgctgggga gcagcgtgtt tactgtgctt ggtcatgagc tgctgggaag ttgtgacttt       60

cactttccct ttcgaattcc agggtatatc tgggaggccg gaggacgtgt ctggttatta      120

cacagatgca cagctggacg tgggatccac acagctcaga acagttggat cttgctcagt      180

ctctgtcaga ggaagatccc ttggacaaga ggaccctgcc ttggtgtgag agtgagggaa      240

gaggaagctg gaacgagggt taaggaaaac cttccagtct ggacagtgac tggagagctc      300

caaggaaagc ccctcggtaa cccagccgct ggcaccatga acccagagag cagtatcttt      360

attgaggatt accttaagta tttccaggac caagtgagca gagagaatct gctacaactg      420

ctgactgatg atgaagcctg gaatggattc gtggctgctg ctgaactgcc cagggatgag      480

gcagatgagc tccgtaaagc tctgaacaag cttgcaagtc acatggtcat gaaggacaaa      540

aaccgccacg ataaagacca gcagcacagg cagtggtttt tgaaagagtt tcctcggttg      600

aaaagggagc ttgaggatca cataaggaag ctccgtgccc ttgcagagga ggttgagcag      660

gtccacagag gcaccaccat tgccaatgtg gtgtccaact ctgttggcac tacctctggc      720

atcctgaccc tcctcggcct gggtctggca cccttcacag aaggaatcag ttttgtgctc      780

ttggacactg gcatgggtct gggagcagca gctgctgtgg ctgggattac ctgcagtgtg      840

gtagaactag taaacaaatt gcgggcacga gcccaagccc gcaacttgga ccaaagcggc      900

accaatgtag caaaggtgat gaaggagttt gtgggtggga acacacccaa tgttcttacc      960

ttagttgaca attggtacca agtcacacaa gggattggga ggaacatccg tgccatcaga     1020

cgagccagag ccaaccctca gttaggagcg tatgccccac ccccgcatat cattgggcga     1080

atctcagctg aaggcggtga acaggttgag agggttgttg aaggccccgc ccaggcaatg     1140

agcagaggaa ccatgatcgt gggtgcagcc actggaggca tcttgcttct gctggatgtg     1200

gtcagccttg catatgagtc aaagcacttg cttgaggggg caaagtcaga gtcagctgag     1260

gagctgaaga agcgggctca ggagctggag gggaagctca actttctcac caagatccat     1320

gagatgctgc agccaggcca agaccaatga ccccagagca gtgcagccac cagggcagaa     1380

atgccgggca caggccagga caaaatgcag actttttttt tttttttttt ttttttttga     1440

gatggagtct cgctctatcg cccaggatgg agtgcagtgg ctcaatctcg gctcactgca     1500

aactccgcct cccgggttca caccattctc cggcctcagt ctcccgagta gctgggacta     1560

caggcacctg ccaccacgcc cggctaattt ttttgtattt tcactggaga cggggtttca     1620

ctgtgttagc cacgatggtc tccatctcct gacctcgtga tctgcccacc tcggcctccc     1680

aaagtgctgg gattacaggc gtgagccacc gcgcctggcc aaaatgcaga cattttatta     1740

gggggataag gagggcaagg taaagcttat ggaactgagt gttagtgact ttggcatttg     1800

tgtagctgag cacagcaagg gaggggttaa tgcagatggc aagtgcacca aggagaaggc     1860

aggaacactg gagcctgcaa taagggagga gagaggactg gagagtgtgg ggaatgggaa     1920

gaagtagttt actttggact aaagaatata ttgggcgaag aatagagggg gagcttgcag     1980

gaaccagcaa tgagaaggcc aggaaaagaa agagctgaaa atggagaaaa ccagagttag     2040

aactgttgga tacaggagaa gaaacagcag ctccactacc gacccccccc caggtttgat     2100

gtccttccaa gaataaagtc tttccctggt gatggtctct cgctctgtct ttccagcatc     2160

cactctccct tgtccttctg ggggtgtatc acagtcagcc agtggcttct tcatgatggt     2220

ggttggggtg gttgtcatgt gacgggtccc ctccaggtta ctaaagggtg catgtcccct     2280

gcttgaaccc tgagaggcag gtggtaggcc atggccacaa tccccagctg aggagcaggt     2340

gtccctgaga acccaaactt cccagagagt atctgagaac caaccaatga aaacagtccc     2400

atcgctctta gccggtaagt aaacagtcag aagattagca tgaaagcagt ttagcattgg     2460

gaggaagcac agatctctag agctgtcctg tcgctgccca ggattgacct gtgtgtaagt     2520

cccaataaac tcacctactc accaa                                           2545


<210> 408
<211> 337
<212> PRT
<213> Homo sapiens

<400> 408
Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe 
1               5                   10                  15      


Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Thr Asp Asp 
            20                  25                  30          


Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val 
    50                  55                  60                  


Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His Arg Gln Trp 
65                  70                  75                  80  


Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu Asp His Ile 
                85                  90                  95      


Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val His Arg Gly 
            100                 105                 110         


Thr Thr Ile Ala Asn Val Val Ser Asn Ser Val Gly Thr Thr Ser Gly 
        115                 120                 125             


Ile Leu Thr Leu Leu Gly Leu Gly Leu Ala Pro Phe Thr Glu Gly Ile 
    130                 135                 140                 


Ser Phe Val Leu Leu Asp Thr Gly Met Gly Leu Gly Ala Ala Ala Ala 
145                 150                 155                 160 


Val Ala Gly Ile Thr Cys Ser Val Val Glu Leu Val Asn Lys Leu Arg 
                165                 170                 175     


Ala Arg Ala Gln Ala Arg Asn Leu Asp Gln Ser Gly Thr Asn Val Ala 
            180                 185                 190         


Lys Val Met Lys Glu Phe Val Gly Gly Asn Thr Pro Asn Val Leu Thr 
        195                 200                 205             


Leu Val Asp Asn Trp Tyr Gln Val Thr Gln Gly Ile Gly Arg Asn Ile 
    210                 215                 220                 


Arg Ala Ile Arg Arg Ala Arg Ala Asn Pro Gln Leu Gly Ala Tyr Ala 
225                 230                 235                 240 


Pro Pro Pro His Ile Ile Gly Arg Ile Ser Ala Glu Gly Gly Glu Gln 
                245                 250                 255     


Val Glu Arg Val Val Glu Gly Pro Ala Gln Ala Met Ser Arg Gly Thr 
            260                 265                 270         


Met Ile Val Gly Ala Ala Thr Gly Gly Ile Leu Leu Leu Leu Asp Val 
        275                 280                 285             


Val Ser Leu Ala Tyr Glu Ser Lys His Leu Leu Glu Gly Ala Lys Ser 
    290                 295                 300                 


Glu Ser Ala Glu Glu Leu Lys Lys Arg Ala Gln Glu Leu Glu Gly Lys 
305                 310                 315                 320 


Leu Asn Phe Leu Thr Lys Ile His Glu Met Leu Gln Pro Gly Gln Asp 
                325                 330                 335     


Gln 
    


<210> 409
<211> 1947
<212> DNA
<213> Homo sapiens

<400> 409
gctgaacttc cggcctcagg acgcaggcgc gggccgctca tttcgctctt tccggcggtg       60

ctcgcaagcg aggcagccat gtcttatccc gctgatgatt atgagtctga ggcggcttat      120

gacccctacg cttatcccag cgactatgat atgcacacag gagatccaaa gcaggacctt      180

gcttatgaac gtcagtatga acagcaaacc tatcaggtga tccctgaggt gatcaaaaac      240

ttcatccagt atttccacaa aactgtctca gatttgattg accagaaagt gtatgagcta      300

caggccagtc gtgtctccag tgatgtcatt gaccagaagg tgtatgagat ccaggacatc      360

tatgagaaca gctggaccaa gctgactgaa agattcttca agaatacacc ttggcccgag      420

gctgaagcca ttgctccaca ggttggcaat gatgctgtct tcctgatttt atacaaagaa      480

ttatactaca ggcacatata tgccaaagtc agttttcagt cattcagtca gtaccgctgt      540

aagactgcca agaagtcaga ggaggagatt gactttcttc gttccaatcc caaaatctgg      600

aatgttcata gtgtcctcaa tgtccttcat tccctggtag acaaatccaa catcaaccga      660

cagttggagg tatacacaag cggaggtgac cctgagagtg tggctgggga gtatgggcgg      720

cactccctct acaaaatgct tggttacttc agcctggtcg ggcttctccg cctgcactcc      780

ctgttaggag attactacca ggccatcaag gtgctggaga acatcgaact gaacaagaag      840

agtatgtatt cccgtgtgcc agagtgccag gtcaccacat actattatgt tgggtttgca      900

tatttgatga tgcgtcgtta ccaggatgcc atccgggtct tcgccaacat cctcctctac      960

atccagagga ccaagagcat gttccagagg accacgtaca agtatgagat gattaacaag     1020

cagaatgagc agatgcatgc gctgctggcc attgccctca cgatgtaccc catgcgtatt     1080

gatgagagca ttcacctcca gctgcgggag aaatatgggg acaagatgtt gcgcatgcag     1140

aaaggtgacc cacaagtcta tgaagaactt ttcagttact cctgccccaa gttcctgtcg     1200

cctgtagtgc ccaactatga taatgtgcac cccaactacc acaaagagcc cttcctgcag     1260

cagctgaagg tgttttctga tgaagtacag cagcaggccc agctttcaac catccgcagc     1320

ttcctgaagc tctacaccac catgcctgtg gccaagctgg ctggcttcct ggacctcaca     1380

gagcaggagt tccggatcca gcttcttgtc ttcaaacaca agatgaagaa cctcgtgtgg     1440

accagcggta tctcagccct ggatggtgaa tttcagtcag cctcagaggt tgacttctac     1500

attgataagg acatgatcca catcgcggac accaaggtcg ccaggcgtta tggggatttc     1560

ttcatccgtc agatccacaa atttgaggag cttaatcgaa ccctgaagaa gatgggacag     1620

agaccttgat gatattcaca cacattcagg aacctgtttt gatgtattat aggcaggaag     1680

tgtttttgct accgtgaaac ctttacctag atcagccatc agcctgtcaa ctcagttaac     1740

aagttaagga ccgaagtgtt tcaagtggat ctcagtaaag gatctttgga gccagatttg     1800

tcgtctcatt attgtaggag agaatttgtg ggttgtggca gtaatacatt tcccatgtgt     1860

cctgatgctt tcaggataca tcagttgtta gtgtttaaat tgagttattt ttattttgtg     1920

cttttgagat ggagtctcac tctgtct                                         1947


<210> 410
<211> 516
<212> PRT
<213> Homo sapiens

<400> 410
Met Ser Tyr Pro Ala Asp Asp Tyr Glu Ser Glu Ala Ala Tyr Asp Pro 
1               5                   10                  15      


Tyr Ala Tyr Pro Ser Asp Tyr Asp Met His Thr Gly Asp Pro Lys Gln 
            20                  25                  30          


Asp Leu Ala Tyr Glu Arg Gln Tyr Glu Gln Gln Thr Tyr Gln Val Ile 
        35                  40                  45              


Pro Glu Val Ile Lys Asn Phe Ile Gln Tyr Phe His Lys Thr Val Ser 
    50                  55                  60                  


Asp Leu Ile Asp Gln Lys Val Tyr Glu Leu Gln Ala Ser Arg Val Ser 
65                  70                  75                  80  


Ser Asp Val Ile Asp Gln Lys Val Tyr Glu Ile Gln Asp Ile Tyr Glu 
                85                  90                  95      


Asn Ser Trp Thr Lys Leu Thr Glu Arg Phe Phe Lys Asn Thr Pro Trp 
            100                 105                 110         


Pro Glu Ala Glu Ala Ile Ala Pro Gln Val Gly Asn Asp Ala Val Phe 
        115                 120                 125             


Leu Ile Leu Tyr Lys Glu Leu Tyr Tyr Arg His Ile Tyr Ala Lys Val 
    130                 135                 140                 


Ser Phe Gln Ser Phe Ser Gln Tyr Arg Cys Lys Thr Ala Lys Lys Ser 
145                 150                 155                 160 


Glu Glu Glu Ile Asp Phe Leu Arg Ser Asn Pro Lys Ile Trp Asn Val 
                165                 170                 175     


His Ser Val Leu Asn Val Leu His Ser Leu Val Asp Lys Ser Asn Ile 
            180                 185                 190         


Asn Arg Gln Leu Glu Val Tyr Thr Ser Gly Gly Asp Pro Glu Ser Val 
        195                 200                 205             


Ala Gly Glu Tyr Gly Arg His Ser Leu Tyr Lys Met Leu Gly Tyr Phe 
    210                 215                 220                 


Ser Leu Val Gly Leu Leu Arg Leu His Ser Leu Leu Gly Asp Tyr Tyr 
225                 230                 235                 240 


Gln Ala Ile Lys Val Leu Glu Asn Ile Glu Leu Asn Lys Lys Ser Met 
                245                 250                 255     


Tyr Ser Arg Val Pro Glu Cys Gln Val Thr Thr Tyr Tyr Tyr Val Gly 
            260                 265                 270         


Phe Ala Tyr Leu Met Met Arg Arg Tyr Gln Asp Ala Ile Arg Val Phe 
        275                 280                 285             


Ala Asn Ile Leu Leu Tyr Ile Gln Arg Thr Lys Ser Met Phe Gln Arg 
    290                 295                 300                 


Thr Thr Tyr Lys Tyr Glu Met Ile Asn Lys Gln Asn Glu Gln Met His 
305                 310                 315                 320 


Ala Leu Leu Ala Ile Ala Leu Thr Met Tyr Pro Met Arg Ile Asp Glu 
                325                 330                 335     


Ser Ile His Leu Gln Leu Arg Glu Lys Tyr Gly Asp Lys Met Leu Arg 
            340                 345                 350         


Met Gln Lys Gly Asp Pro Gln Val Tyr Glu Glu Leu Phe Ser Tyr Ser 
        355                 360                 365             


Cys Pro Lys Phe Leu Ser Pro Val Val Pro Asn Tyr Asp Asn Val His 
    370                 375                 380                 


Pro Asn Tyr His Lys Glu Pro Phe Leu Gln Gln Leu Lys Val Phe Ser 
385                 390                 395                 400 


Asp Glu Val Gln Gln Gln Ala Gln Leu Ser Thr Ile Arg Ser Phe Leu 
                405                 410                 415     


Lys Leu Tyr Thr Thr Met Pro Val Ala Lys Leu Ala Gly Phe Leu Asp 
            420                 425                 430         


Leu Thr Glu Gln Glu Phe Arg Ile Gln Leu Leu Val Phe Lys His Lys 
        435                 440                 445             


Met Lys Asn Leu Val Trp Thr Ser Gly Ile Ser Ala Leu Asp Gly Glu 
    450                 455                 460                 


Phe Gln Ser Ala Ser Glu Val Asp Phe Tyr Ile Asp Lys Asp Met Ile 
465                 470                 475                 480 


His Ile Ala Asp Thr Lys Val Ala Arg Arg Tyr Gly Asp Phe Phe Ile 
                485                 490                 495     


Arg Gln Ile His Lys Phe Glu Glu Leu Asn Arg Thr Leu Lys Lys Met 
            500                 505                 510         


Gly Gln Arg Pro 
        515     


<210> 411
<211> 1955
<212> DNA
<213> Homo sapiens

<400> 411
gcgggcgggg cctctggggc ggagcggcca ccatcttgga acgggaggcg gagcagagtc       60

gactgggagc gaccgagcgg gccgccgccg ccgccatgaa ccccgaatat gactacctgt      120

ttaagctgct tttgattggc gactcaggcg tgggcaagtc atgcctgctc ctgcggtttg      180

ctgatgacac gtacacagag agctacatca gcaccatcgg ggtggacttc aagatccgaa      240

ccatcgagct ggatggcaaa actatcaaac ttcagatctg ggacacagcg ggccaggaac      300

ggttccggac catcacttcc agctactacc ggggggctca tggcatcatc gtggtgtatg      360

acgtcactga ccaggaatcc tacgccaacg tgaagcagtg gctgcaggag attgaccgct      420

atgccagcga gaacgtcaat aagctcctgg tgggcaacaa gagcgacctc accaccaaga      480

aggtggtgga caacaccaca gccaaggagt ttgcagactc tctgggcatc cccttcttgg      540

agacgagcgc caagaatgcc accaatgtcg agcaggcgtt catgaccatg gctgctgaaa      600

tcaaaaagcg gatggggcct ggagcagcct ctgggggcga gcggcccaat ctcaagatcg      660

acagcacccc tgtaaagccg gctggcggtg gctgttgcta ggaggggcac atggagtggg      720

acaggagggg gcaccttctc cagatgatgt ccctggaggg ggcaggaggt acctccctct      780

ccctctcctg gggcatttga gtctgtggct ttggggtgtc ctgggctccc catctccttc      840

tggcccatct gcctgctgcc ctgagccccg gttctgtcag ggtccctaag ggaggacact      900

cagggcctgt ggccaggcag ggcggaggcc tgctgtgctg ttgcctctag gtgactttcc      960

aagatgcccc cctacacacc tttctttgga acgagggctc ttctgtcggt gtccctccca     1020

cccccatgta tgctgcactg ggttctctcc ttcttcttcc tgctgtcctg cccaagaact     1080

gagggtctcc ccggcctcta ctgccctggc tgcagtcagt gcccagggcg aggaatgtgg     1140

ccaggggatc caggacctgg gatccagggc cctgggctgg acctcaggac aggcatggag     1200

gccacagggg cccagcagcc caccctttcc tctccccact gcctcctctc ccttcctaca     1260

ctcccagctc gagccgtcca gctgcggtgg gatctgagta tatctagggc gggtgggcgg     1320

gtagcagtgc tgggcctgtg tcttgagcct ggagggagtc tgctcctgcc gccctctgcc     1380

ctgccagaga cagacccatg cgctgcctgc ccaccgtgcc cctttgtccc catgtcaggc     1440

ggaggcggaa ggcccaccgt gccagaggct gggcaccagc cttaaccctc actctgctag     1500

cacctcctcc ctttccccaa ggtagcacat ctggctcact ccccactccg tctctggagc     1560

ccaccaggga aggccctcat cccctgccgc tacttctctg gggaatgtgg gttccatcca     1620

ggattggggg cctctctgct cacccactct gcacccagga tcctagtccc ctgccctctg     1680

gcacagctgc ttcctgcaag aaagcaagtc tttggtctcc ctgagaagcc atgtccctcg     1740

tgctgtctct tgcctgtccc acctgtgccc tgccctccag cttgtattta agtccctggg     1800

ctgccccctt ggggtgcccc ccgctcccag gttcccctct ggtgtcatgt caggcatttt     1860

gcaaggaaaa gccacttggg gaaagatgga aaaggacaaa aaaaattaat aaatttccat     1920

tggccctcgg gtgagctgag ggtttttgca aggaa                                1955


<210> 412
<211> 201
<212> PRT
<213> Homo sapiens

<400> 412
Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr 
            20                  25                  30          


Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr 
                85                  90                  95      


Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu 
            100                 105                 110         


Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys 
        115                 120                 125             


Lys Val Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly 
    130                 135                 140                 


Ile Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln 
145                 150                 155                 160 


Ala Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met Gly Pro Gly 
                165                 170                 175     


Ala Ala Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro 
            180                 185                 190         


Val Lys Pro Ala Gly Gly Gly Cys Cys 
        195                 200     


<210> 413
<211> 829
<212> DNA
<213> Homo sapiens

<400> 413
cctcttttcc gtggcgcctc ggaggcgttc agctgcttca agatgaagct gaacatctcc       60

ttcccagcca ctggctgcca gaaactcatt gaagtggacg atgaacgcaa acttcgtact      120

ttctatgaga agcgtatggc cacagaagtt gctgctgacg ctctgggtga agaatggaag      180

ggttatgtgg tccgaatcag tggtgggaac gacaaacaag gtttccccat gaagcagggt      240

gtcttgaccc atggccgtgt ccgcctgcta ctgagtaagg ggcattcctg ttacagacca      300

aggagaactg gagaaagaaa gagaaaatca gttcgtggtt gcattgtgga tgcaaatctg      360

agcgttctca acttggttat tgtaaaaaaa ggagagaagg atattcctgg actgactgat      420

actacagtgc ctcgccgcct gggccccaaa agagctagca gaatccgcaa acttttcaat      480

ctctctaaag aagatgatgt ccgccagtat gttgtaagaa agcccttaaa taaagaaggt      540

aagaaaccta ggaccaaagc acccaagatt cagcgtcttg ttactccacg tgtcctgcag      600

cacaaacggc ggcgtattgc tctgaagaag cagcgtacca agaaaaataa agaagaggct      660

gcagaatatg ctaaactttt ggccaagaga atgaaggagg ctaaggagaa gcgccaggaa      720

caaattgcga agagacgcag actttcctct ctgcgagctt ctacttctaa gtctgaatcc      780

agtcagaaat aagatttttt gagtaacaaa taaataagat cagactctg                  829


<210> 414
<211> 249
<212> PRT
<213> Homo sapiens

<400> 414
Met Lys Leu Asn Ile Ser Phe Pro Ala Thr Gly Cys Gln Lys Leu Ile 
1               5                   10                  15      


Glu Val Asp Asp Glu Arg Lys Leu Arg Thr Phe Tyr Glu Lys Arg Met 
            20                  25                  30          


Ala Thr Glu Val Ala Ala Asp Ala Leu Gly Glu Glu Trp Lys Gly Tyr 
        35                  40                  45              


Val Val Arg Ile Ser Gly Gly Asn Asp Lys Gln Gly Phe Pro Met Lys 
    50                  55                  60                  


Gln Gly Val Leu Thr His Gly Arg Val Arg Leu Leu Leu Ser Lys Gly 
65                  70                  75                  80  


His Ser Cys Tyr Arg Pro Arg Arg Thr Gly Glu Arg Lys Arg Lys Ser 
                85                  90                  95      


Val Arg Gly Cys Ile Val Asp Ala Asn Leu Ser Val Leu Asn Leu Val 
            100                 105                 110         


Ile Val Lys Lys Gly Glu Lys Asp Ile Pro Gly Leu Thr Asp Thr Thr 
        115                 120                 125             


Val Pro Arg Arg Leu Gly Pro Lys Arg Ala Ser Arg Ile Arg Lys Leu 
    130                 135                 140                 


Phe Asn Leu Ser Lys Glu Asp Asp Val Arg Gln Tyr Val Val Arg Lys 
145                 150                 155                 160 


Pro Leu Asn Lys Glu Gly Lys Lys Pro Arg Thr Lys Ala Pro Lys Ile 
                165                 170                 175     


Gln Arg Leu Val Thr Pro Arg Val Leu Gln His Lys Arg Arg Arg Ile 
            180                 185                 190         


Ala Leu Lys Lys Gln Arg Thr Lys Lys Asn Lys Glu Glu Ala Ala Glu 
        195                 200                 205             


Tyr Ala Lys Leu Leu Ala Lys Arg Met Lys Glu Ala Lys Glu Lys Arg 
    210                 215                 220                 


Gln Glu Gln Ile Ala Lys Arg Arg Arg Leu Ser Ser Leu Arg Ala Ser 
225                 230                 235                 240 


Thr Ser Lys Ser Glu Ser Ser Gln Lys 
                245                 


<210> 415
<211> 1820
<212> DNA
<213> Homo sapiens

<400> 415
gccggggcca ggaggaggcg ggcgcaggag gcgcgtgctc agtgtgctgg gtaccaggcg       60

actccgggac agggggtctc ggccgtcggc gtcatggttt cgcgcgtgca gctcccgcct      120

gagatccagc tggctcagcg cctggcgggg aatgagcagg tgacccggga ccgggcggtg      180

aggaagctcc ggaaatacat cgtcgccagg actcagcggg ccgcaggtgg ttttacgcac      240

gacgagctgc tgaaggtgtg gaaaggactg ttttattgca tgtggatgca ggacaagcca      300

ctcctccagg aagaattagg aaggactatt tcccagctcg ttcatgcttt tcagaccacg      360

gaggcgcagc acctgttcct tcaggccttc tggcagacca tgaatcgcga gtggacgggc      420

attgacaggc tgcgcctgga taaattctac atgctcatgc ggatggtcct gaacgagtcc      480

ttgaaggttc tgaagatgca aggctgggaa gaaagacaga tcgaggagct gctagagctg      540

ctgatgactg agatcctgca ccccagcagc caggccccca acggtgtgaa gagccacttc      600

atcgagatct tcctggagga gctgaccaaa gtgggcgccg aggagcttac ggcagaccag      660

aacctgaagt tcatcgaccc cttctgcaga attgctgccc ggaccaagga ttccttggtt      720

ttgaacaaca tcactcgagg catctttgag acgattgtgg agcaggcccc gcttgccatt      780

gaagacctcc tgaatgaact ggacacacag gatgaggagg tggcgtcgga cagtgatgag      840

tcctctgagg gtggtgagcg tggagacgcg ctgtcccaga agaggtctga gaagccgccc      900

gcaggctcca tctgcagggc tgaacctgag gctggtgagg agcaggcagg tgacgacagg      960

gacagtggcg gccccgttct ccagtttgac tacgaggcag ttgctaacag actgtttgaa     1020

atggccagcc gccagagcac cccttctcag aacagaaagc gtctctacaa agtgatccgg     1080

aagctgcagg acctggcagg aggcattttc cctgaagatg agatcccaga gaaggcctgc     1140

aggcgcctgc ttgaagggag gcggcagaag aagacgaaga agcagaagcg tctgctcagg     1200

ttgcagcagg agagagggaa aggtgagaag gagcccccga gcccgggcat ggagaggaag     1260

aggagcagga ggaggggtgt aggggccgac cccgaggcgc gggcagaggc tggtgagcag     1320

ccaggcacag ctgagcgggc cctgctccga gatcagccca ggggccgtgg ccagagaggg     1380

gctcgccaga gaaggaggac acctcggccc ctgaccagtg cccgagcaaa ggcggccaat     1440

gtccaggagc cggagaagaa gaagaaacgc agggagtgat gtggccgggc caaggacagg     1500

cagggaggga ggccaggcct cgcttgcacc gcgggacgag gctgaccggg ctgttctgta     1560

gactcaggac cgtggctcca gaactcctgt gccaggcggg agggaagggc ggcactggag     1620

agatgggccc atcattaggg gccagcatcc caggaactgg acctttcccc agagcctccg     1680

cctgtggctg tgatgacctt gggccagaag gtcaaactcc gaagactgaa actctgcctg     1740

cagcaggact ggccgcccct gctgtggggg gttcagaaaa taaaatgccg cgcagccctt     1800

gccagggaaa aaaaaaaaaa                                                 1820


<210> 416
<211> 461
<212> PRT
<213> Homo sapiens

<400> 416
Met Val Ser Arg Val Gln Leu Pro Pro Glu Ile Gln Leu Ala Gln Arg 
1               5                   10                  15      


Leu Ala Gly Asn Glu Gln Val Thr Arg Asp Arg Ala Val Arg Lys Leu 
            20                  25                  30          


Arg Lys Tyr Ile Val Ala Arg Thr Gln Arg Ala Ala Gly Gly Phe Thr 
        35                  40                  45              


His Asp Glu Leu Leu Lys Val Trp Lys Gly Leu Phe Tyr Cys Met Trp 
    50                  55                  60                  


Met Gln Asp Lys Pro Leu Leu Gln Glu Glu Leu Gly Arg Thr Ile Ser 
65                  70                  75                  80  


Gln Leu Val His Ala Phe Gln Thr Thr Glu Ala Gln His Leu Phe Leu 
                85                  90                  95      


Gln Ala Phe Trp Gln Thr Met Asn Arg Glu Trp Thr Gly Ile Asp Arg 
            100                 105                 110         


Leu Arg Leu Asp Lys Phe Tyr Met Leu Met Arg Met Val Leu Asn Glu 
        115                 120                 125             


Ser Leu Lys Val Leu Lys Met Gln Gly Trp Glu Glu Arg Gln Ile Glu 
    130                 135                 140                 


Glu Leu Leu Glu Leu Leu Met Thr Glu Ile Leu His Pro Ser Ser Gln 
145                 150                 155                 160 


Ala Pro Asn Gly Val Lys Ser His Phe Ile Glu Ile Phe Leu Glu Glu 
                165                 170                 175     


Leu Thr Lys Val Gly Ala Glu Glu Leu Thr Ala Asp Gln Asn Leu Lys 
            180                 185                 190         


Phe Ile Asp Pro Phe Cys Arg Ile Ala Ala Arg Thr Lys Asp Ser Leu 
        195                 200                 205             


Val Leu Asn Asn Ile Thr Arg Gly Ile Phe Glu Thr Ile Val Glu Gln 
    210                 215                 220                 


Ala Pro Leu Ala Ile Glu Asp Leu Leu Asn Glu Leu Asp Thr Gln Asp 
225                 230                 235                 240 


Glu Glu Val Ala Ser Asp Ser Asp Glu Ser Ser Glu Gly Gly Glu Arg 
                245                 250                 255     


Gly Asp Ala Leu Ser Gln Lys Arg Ser Glu Lys Pro Pro Ala Gly Ser 
            260                 265                 270         


Ile Cys Arg Ala Glu Pro Glu Ala Gly Glu Glu Gln Ala Gly Asp Asp 
        275                 280                 285             


Arg Asp Ser Gly Gly Pro Val Leu Gln Phe Asp Tyr Glu Ala Val Ala 
    290                 295                 300                 


Asn Arg Leu Phe Glu Met Ala Ser Arg Gln Ser Thr Pro Ser Gln Asn 
305                 310                 315                 320 


Arg Lys Arg Leu Tyr Lys Val Ile Arg Lys Leu Gln Asp Leu Ala Gly 
                325                 330                 335     


Gly Ile Phe Pro Glu Asp Glu Ile Pro Glu Lys Ala Cys Arg Arg Leu 
            340                 345                 350         


Leu Glu Gly Arg Arg Gln Lys Lys Thr Lys Lys Gln Lys Arg Leu Leu 
        355                 360                 365             


Arg Leu Gln Gln Glu Arg Gly Lys Gly Glu Lys Glu Pro Pro Ser Pro 
    370                 375                 380                 


Gly Met Glu Arg Lys Arg Ser Arg Arg Arg Gly Val Gly Ala Asp Pro 
385                 390                 395                 400 


Glu Ala Arg Ala Glu Ala Gly Glu Gln Pro Gly Thr Ala Glu Arg Ala 
                405                 410                 415     


Leu Leu Arg Asp Gln Pro Arg Gly Arg Gly Gln Arg Gly Ala Arg Gln 
            420                 425                 430         


Arg Arg Arg Thr Pro Arg Pro Leu Thr Ser Ala Arg Ala Lys Ala Ala 
        435                 440                 445             


Asn Val Gln Glu Pro Glu Lys Lys Lys Lys Arg Arg Glu 
    450                 455                 460     


<210> 417
<211> 5582
<212> DNA
<213> Homo sapiens

<400> 417
ggcgtggggg gagcagatgc cgctggctgc cagcgggacg ccggcgagca gagcgcagcc       60

gcgagggagg cgcgagggag gcgagccgga gcccgagcac tagcagcagc cggagtcggc      120

gtaaagcacc cgggcgcagc cggagccggt gccgcagctg cgatggccgt ggccgtgggg      180

agaccgtcta atgaagagct tcgaaacttg tctttgtctg gccatgtggg atttgacagc      240

ctccctgacc agctggtcaa caagtctact tctcaaggat tctgtttcaa catcctttgt      300

gttggtgaga caggcattgg caaatccacg ttaatggaca ctttgttcaa caccaaattt      360

gaaagtgacc cagctactca caatgaacca ggtgttcggt taaaagccag aagttatgag      420

cttcaggaaa gcaatgtacg gctgaagtta accattgttg acaccgtggg atttggagac      480

cagataaata aagatgacag ctataagccg atagtagaat atattgatgc ccagttcgag      540

gcctacctgc aagaggaatt gaagattaaa cgttctctct tcaactacca tgacacgagg      600

atccatgcct gcctctactt tattgcccct actggacatt cactaaagtc cctggatctg      660

gtcaccatga aaaagctgga cagtaaggtg aacatcattc caataattgc aaaagctgac      720

accattgcca agaatgaact gcacaaattc aagagtaaga tcatgagtga actggtcagc      780

aatggggtcc agatatatca gtttcccact gatgaagaaa cggtggcaga gattaacgca      840

acaatgagtg tccatctccc atttgcagtg gttggcagca ccgaagaggt gaagattggc      900

aacaagatgg caaaggccag gcagtacccc tggggtgtgg tgcaggttga gaatgaaaat      960

cattgcgatt ttgtgaaact tcgagagatg ctgatccgcg tgaacatgga ggacttgcga     1020

gagcagactc acacccgcca ctatgaattg taccgacgct gtaagcttga agagatgggg     1080

ttcaaggaca ctgaccctga cagcaaaccc ttcagtcttc aggagacata tgaagcaaaa     1140

aggaatgaat tcctgggaga actgcagaag aaagaagaag aaatgagaca aatgtttgtt     1200

atgagagtga aggagaaaga agctgaactt aaggaggcag agaaagagct tcacgagaag     1260

tttgaccttc taaagcggac acaccaagaa gaaaagaaga aagtggaaga caagaagaag     1320

gagcttgagg aggaggtgaa caacttccag aagaagaaag cagcggctca gttactacag     1380

tcccaggccc agcaatctgg ggcccagcaa accaagaaag acaaggataa gaaaaatgca     1440

agcttcacat aaagcctggc aagccaagga tgttcccgca ttcacctgct tttgcagtaa     1500

tatcgtatct ctgccatgtg tgttctttag ttttatttta ttttatttta tttttttacc     1560

cttcctcaaa caccagtaac tattattaac tcgttttgct gaatgttgtt gggtggtaga     1620

aaatgataga acaagggaat aaccgcgaat gctctgtgca gctggactct gtttccggaa     1680

agtaaatgat ttgcttttta tgcctgttct gaatggcagc acgaagcagg cctgttactt     1740

gtatgtcgct ttggacagag gaaagtgggg taaaatgcta cctgtacgtc tgacatgaaa     1800

acttctcacc gcctcagcag ctgaactaaa aacctgaata gccatgacaa gagtttgcat     1860

tttcttgatg attcatctcc atgagtgcac aatccctgaa ctcactgtct tttctccaca     1920

cttgtcctaa gccaaggtag atttgtacgt agacagactg gtgagcaagc attatatttt     1980

atttttaccc ttgcatgaca ttttcatttt aatcaataac attatttggc ctgagcttgt     2040

gggtctgttc agactgtctc ctctcatggt ttgaaactgc atctgaatgc ctgccttcaa     2100

tcctggccaa gttggagtag actggtatga gaaaactatg attagttcac atttactggt     2160

gcatccttga tcctctcaca gatagaggtc ttaaaggttg gatcatgtaa cattgcttag     2220

tagaagaatc ttcttctaag gatgatgggc tttctacagc ctgcttacca ctaacagtaa     2280

ggaatctttc ataaacacac ctcagtttgt tcccagtggg cttagaggga ggacctgatg     2340

actgattcca ggatacttgt acttctaata acatttttca tgaatcatga gaaaatttcc     2400

acagatactt cccttagaaa atttgctata aactctgtat cattggtagc acaaatttga     2460

gcgaggcctt gtcaatttta aggtggaaat aggaaggacc acaacatgac ccgtaagtca     2520

agaaggtaga catttcatat ccagcttcct tgcttagtct cctttcagta tttggcaata     2580

aaagaaagaa gaaatagaac agctgaagtc tcaaatcatt gtctggaatt ttcctcacct     2640

tggctagctc cacctgctct ttgtctaagg cccttgcctc atcagggatt agaactggcc     2700

catatgccag aacctgtact aaatgcctaa tttgtatgga agagtgcata tttaatctct     2760

tttctatact gctcctttct gatgcttatc ctttcatctg tgtgattgtt ttttcccctc     2820

tactaacaag atcctcccag ctttctctct acatgtagaa aggataacat ttctcatgaa     2880

cccactgccc ctctgcattt tcctcactgg ttagagatta agtaaatagg atagaatatg     2940

ctgcgtctcc cctgacacac actttctttt ttgaatgagc aagtctccat tttgatttca     3000

gcaaagattt tttctccttt tctttgtcct caaccatact tagaggaaag aaggaatggt     3060

cttccatgaa ctgattatgc ttaattaagc aaagtaagga aattagtttc atggaagcct     3120

aaacaaagct ggaatagaaa ctacacacta gacacagcag tagtcatagt cttcacaggt     3180

ttaggagcta ctggaccaac attcttgttt ttgcttttgt ttttttaaat aattctagtc     3240

tggagctaac tgtggagcag ccaaatagta gctggcatgt tgattcaaac catgggctga     3300

atttgctcat aggctgtgca tcagacaaaa gcttgaatat ttgtgttgta tgcttgttcc     3360

aaccaccgct tgtgtgagca tttttgtggc ttgtacagaa agtacacttt taaattgtct     3420

cttgcatcac taaaattttt ttaaaatgag cataacaacg aaaggcatcc agctgacttt     3480

ttgattccaa gattattgat tggattgact tttttgcatt aaatttttcc cagcaaaata     3540

aatcatatgg cgagtcaggg aataaaaagt caaaagaaac aaatagaagc tttttttttt     3600

aaaaaatgta ttgcttctga acttttttct gccactgctc cctagccctg tttagtttgt     3660

tattgctgct tttctttttt ctttctgtat ctatgccttt ttttcacagt agtccttggc     3720

tctgcacgga ataaatgata ccctcaaatc taattggatg tgctttcgcc tttgcatgta     3780

agtacggtag taagaaacct ttgagatctt tctgactttt caaaattaga gaaagcaaat     3840

gggatggata gatttttttt ttcttttcaa ggggggcagg aaggtaatgg tttgagtagc     3900

ctttgtttaa aaaaaagact aaatatattt aaaaggccac atttatattt ttttcacaag     3960

aaccacataa taaattccac ttcttgacct gaatttggaa atccgaaatt actaatccag     4020

gccaggtgtg gtggctcatg cctgtaatcc cagcactttg agaggccgag gtgggcagat     4080

cacttgaggc ctggagttca agaccacctt ggcgaacacg gtgaaacccc gtctctacaa     4140

aaaatacaaa aattagccag gcgtggtggc acgtgcctgt agtcccagct acttgggagg     4200

ctaagtcagg agaattgctt gaacttggga gatggaggtt gcagtgagcc aagattgcac     4260

cactgcattc caacctgggt gatgaagtga gactctccaa aaaaaaaaaa gaaattatta     4320

atccctgcct gtgctctaca tagcctcatg ggcatcattg gatagctcag agggcccttg     4380

attctggcaa ggcaaataaa gccagaatga gaaattacca tcttctacta gagaaaacca     4440

agagaaaaat ttttatgcta ggatgccttt atgaccactt aattttttaa tcttagttta     4500

atggtctctc cctggtgcta actgctgaca gtggccacct cttttttggg gattgagggg     4560

cctacataac tagctggcct taccccatat cttttgttca aacataatac catctttttg     4620

cttcttctga actttagatc tccataacac atgtactgta gaatgtgatg gaaaagcatt     4680

gatgagaatt tattggcagt tcagattgtg ttttcccaac ttaggctctt tattaattgg     4740

ttaaggtttt ctccaaaaag ggcatttcaa caatgggaat tatttaatgt aacagtgggc     4800

acagattact tatcttcctt ctctgctttg tgactcacca gcagtaacac acacaatcca     4860

catcttgtgc acctcaaatg aacagacttg gtttccttgc tttcttgaca tttccatgac     4920

tgtttcacat acaaactatt gggtgaggtt tttcagctgt taccgaccca cgtcctgctg     4980

tctctgtgtg gtcctacaaa aactgtccat tcccacccct ttgctttgcc atttgcaaga     5040

gtctggaatt gtcaggtctc agcttcgaaa agtcctggtt ccactgacag gacacattct     5100

ttagtgggaa ttaagaccta caaagtctag tttgtatgta ggtatgaagg gaatttttta     5160

aataaattga aaagctgtga acagcattag aactttgtct atttcttaat tttaaaatat     5220

gctgatatgc cttaaactgt agttgtagat ccttgtcatt ttgctgtttg aaaataacca     5280

atgtgttttc taaaactgtc gtgtaatcta ctttcattgt taatgcagaa ttgtcatata     5340

tgtaagctgc atgttagaca tttgtctttt ttaaactaaa gtaattgtat tgatgtgaag     5400

catatcattt tttcaaatat gaaagtgatc acttagcaac atgcttggta atttggcatc     5460

tgttaaggta ggagagtggt gaacagataa tctatgcata tatcactagt gccaagacat     5520

aaagcggggg aaaatatatt tttacccaaa cattaaaaaa aaaaaaaaaa aaaaaaaaaa     5580

aa                                                                    5582


<210> 418
<211> 429
<212> PRT
<213> Homo sapiens

<400> 418
Met Ala Val Ala Val Gly Arg Pro Ser Asn Glu Glu Leu Arg Asn Leu 
1               5                   10                  15      


Ser Leu Ser Gly His Val Gly Phe Asp Ser Leu Pro Asp Gln Leu Val 
            20                  25                  30          


Asn Lys Ser Thr Ser Gln Gly Phe Cys Phe Asn Ile Leu Cys Val Gly 
        35                  40                  45              


Glu Thr Gly Ile Gly Lys Ser Thr Leu Met Asp Thr Leu Phe Asn Thr 
    50                  55                  60                  


Lys Phe Glu Ser Asp Pro Ala Thr His Asn Glu Pro Gly Val Arg Leu 
65                  70                  75                  80  


Lys Ala Arg Ser Tyr Glu Leu Gln Glu Ser Asn Val Arg Leu Lys Leu 
                85                  90                  95      


Thr Ile Val Asp Thr Val Gly Phe Gly Asp Gln Ile Asn Lys Asp Asp 
            100                 105                 110         


Ser Tyr Lys Pro Ile Val Glu Tyr Ile Asp Ala Gln Phe Glu Ala Tyr 
        115                 120                 125             


Leu Gln Glu Glu Leu Lys Ile Lys Arg Ser Leu Phe Asn Tyr His Asp 
    130                 135                 140                 


Thr Arg Ile His Ala Cys Leu Tyr Phe Ile Ala Pro Thr Gly His Ser 
145                 150                 155                 160 


Leu Lys Ser Leu Asp Leu Val Thr Met Lys Lys Leu Asp Ser Lys Val 
                165                 170                 175     


Asn Ile Ile Pro Ile Ile Ala Lys Ala Asp Thr Ile Ala Lys Asn Glu 
            180                 185                 190         


Leu His Lys Phe Lys Ser Lys Ile Met Ser Glu Leu Val Ser Asn Gly 
        195                 200                 205             


Val Gln Ile Tyr Gln Phe Pro Thr Asp Glu Glu Thr Val Ala Glu Ile 
    210                 215                 220                 


Asn Ala Thr Met Ser Val His Leu Pro Phe Ala Val Val Gly Ser Thr 
225                 230                 235                 240 


Glu Glu Val Lys Ile Gly Asn Lys Met Ala Lys Ala Arg Gln Tyr Pro 
                245                 250                 255     


Trp Gly Val Val Gln Val Glu Asn Glu Asn His Cys Asp Phe Val Lys 
            260                 265                 270         


Leu Arg Glu Met Leu Ile Arg Val Asn Met Glu Asp Leu Arg Glu Gln 
        275                 280                 285             


Thr His Thr Arg His Tyr Glu Leu Tyr Arg Arg Cys Lys Leu Glu Glu 
    290                 295                 300                 


Met Gly Phe Lys Asp Thr Asp Pro Asp Ser Lys Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Glu Thr Tyr Glu Ala Lys Arg Asn Glu Phe Leu Gly Glu Leu Gln Lys 
                325                 330                 335     


Lys Glu Glu Glu Met Arg Gln Met Phe Val Met Arg Val Lys Glu Lys 
            340                 345                 350         


Glu Ala Glu Leu Lys Glu Ala Glu Lys Glu Leu His Glu Lys Phe Asp 
        355                 360                 365             


Leu Leu Lys Arg Thr His Gln Glu Glu Lys Lys Lys Val Glu Asp Lys 
    370                 375                 380                 


Lys Lys Glu Leu Glu Glu Glu Val Asn Asn Phe Gln Lys Lys Lys Ala 
385                 390                 395                 400 


Ala Ala Gln Leu Leu Gln Ser Gln Ala Gln Gln Ser Gly Ala Gln Gln 
                405                 410                 415     


Thr Lys Lys Asp Lys Asp Lys Lys Asn Ala Ser Phe Thr 
            420                 425                 


<210> 419
<211> 4377
<212> DNA
<213> Homo sapiens

<400> 419
gagatggaag ccagcctccg ctaggcccgg aagcctcgtc tgagggggcg ggggacggag       60

gagggagcgg gagtcgagcg agagcctgtg gaggagtccg cctgctgtag cgtgcgtaag      120

caaggcagct acgccgggcg gctacgctgc ggaatcggcg taggcgcctt tggagaatcg      180

gcgggctgcg ctccgctggg gctggtcgcg gaggggggga ggggatgtcg gtcagtgcga      240

gatccgctgc tgctgaggag aggagcgtca acagcagcac catggctcaa cagaagaacc      300

ttgaaggcta tgtgggattt gccaatctcc caaatcaagt atacagaaaa tcggtgaaga      360

gaggttttga attcacgctt atggtagtgg gtgaatctgg attgggaaag tcgacattaa      420

tcaactcatt attcctcaca gatttgtatt ctccagagta tccaggtcct tctcatagaa      480

ttaaaaagac tgtacaggtg gaacaatcca aagttttaat caaagaaggt ggtgttcagt      540

tgctgctcac aatagttgat accccaggat ttggagatgc agtggataat agtaattgct      600

ggcagcctgt tatcgactac attgatagta aatttgagga ctacctaaat gcagaatcac      660

gagtgaacag acgtcagatg cctgataaca gggtgcagtg ttgtttatac ttcattgctc      720

cttcaggaca tggacttaaa ccattggata ttgagtttat gaagcgtttg catgaaaaag      780

tgaatatcat cccacttatt gccaaagcag acacactcac accagaggaa tgccaacagt      840

ttaaaaaaca gataatgaaa gaaatccaag aacataaaat taaaatatac gaatttccag      900

aaacagatga tgaagaagaa aataaacttg ttaaaaagat aaaggaccgt ttacctcttg      960

ctgtggtagg tagtaatact atcattgaag ttaatggcaa aagggtcaga ggaaggcagt     1020

atccttgggg tgttgctgaa gttgaaaatg gtgaacattg tgattttaca atcctaagaa     1080

atatgttgat aagaacacac atgcaggact tgaaagatgt tactaataat gtccactatg     1140

agaactacag aagcagaaaa cttgcagctg tgacttataa tggagttgat aacaacaaga     1200

ataaagggca gctgactaag agccctctgg cacaaatgga agaagaaaga agggagcatg     1260

tagctaaaat gaagaagatg gagatggaga tggagcaggt gtttgagatg aaggtcaaag     1320

aaaaagttca aaaactgaag gactctgaag ctgagctcca gcggcgccat gagcaaatga     1380

aaaagaattt ggaagcacag cacaaagaat tggaggaaaa acgtcgtcag ttcgaggatg     1440

agaaagcaaa ctgggaagct caacaacgta ttttagaaca acagaactct tcaagaacct     1500

tggaaaagaa caagaagaaa gggaagatct tttaaactct ctattgacca ccagttaacg     1560

tattagttgc caatatgcca gcttggacat cagtgtttgt tggatccgtt tgaccaattt     1620

gcaccagttt tatccataat gatggattta acagcatgac aaaaattatt tttttttttg     1680

ttcttgatgg agattaagat gccttgaatt gtctagggtg ttctgtactt agaaagtaag     1740

agctctaagt acctttccta cattttcttt ttttattaaa cagatatctt cagtttaatg     1800

caagagaaca ttttactgtt gtacaatcat gttctggtgg tttgattgtt tacaggatat     1860

tccaaaataa aaggactctg gaagattttc attgaggata aattgccata atatgatgca     1920

aactgtgctt ctctatgata attacaatac aaaggttcca ttcagtgcag catatacaat     1980

aatgtaattt agtctaacac agttgaccct attttttgac acttccattg tttaaaaata     2040

cacatggaaa aaaaaaaaac cctatatgct tactgtgcac ctagagcttt tttataacaa     2100

cgtctttttg tttgtttgtt ttggattctt taaatatata ttattctcat ttagtgccct     2160

ctttagccag aatctcatta ctgcttcatt tttgtaataa catttaattt agatattttc     2220

catatattgg cactgctaaa atagaatata gcatctttca tatggtagga accaacaagg     2280

aaactttcct ttaactccct ttttacactt tatggtaagt agcagggggg gaaatgcatt     2340

tatagatcat ttctaggcaa aattgtgaag ctaatgacca acctgtttct acctatatgc     2400

agtctcttta ttttactaga aatgggaatc atggcctctt gaagagaaaa aagtcaccat     2460

tctgcattta gctgtattca tatattgcat ttctgtattt tttgtttgta ttgtaaaaaa     2520

ttcacataat aaacgatgtt gtgatgtaat attgtgtgag gtcttaaata tcctacagtc     2580

gatgtacaag agtagagtat gtttgggaag aaacttttca gcttaagttt gcctcctcta     2640

caatgacatc ttttatatgc ttgtctcatt tagaatgcat atgtgctgat tttctaattt     2700

aagagatacc atatctctct attcatttct atctctcatt tgtatgctta tttttctgag     2760

aacatttttt ttttccccca gacagggtct tgcttcattg cccaggctgg agtgcggtgg     2820

cacaaacacg acttgactgc agcctcaacc ctctgggctc aagcagtcct cctgcctcag     2880

ccccctgagt atctgggatt gcaggcgtgc accaccacgc ctggctaatt tttgtatttt     2940

ttgcagcctc ccaaagttct gggattacag gcatgagccg tcatgcctgg cctctgagaa     3000

cagtttctga ctcattcaga ttaggtatac tctcaagtcc ctggaaactg aaattttttt     3060

taactgtaaa gagggtagtg tcatttcttt tcttaaggtc aagtgacata gattttaatg     3120

taatgcataa tttaggtaag aaattaatta atgtagccta gtttattatc ttgaaatgtt     3180

ttaccctatt tactttttaa aattaatgac ctaagcggag ggaataatta taagtcaata     3240

gcagagagat tgttgtttgg gtgtttattt ttttcagttt ttgttttgag agattgggtt     3300

aacacctcta gccaaaattg tttggtttta gggaggctaa caataaccta ctgaatttgg     3360

aaaatgcaaa ggtaaaaaat gtatatagac tgcctgctga actggttaag tactactgct     3420

tctgggaaat actatttcaa aattctatgt attataataa taaatttgta agacattcat     3480

tattctacca tcctaatgaa aactttcaga agtctttctt tatccatggc atgcccaggg     3540

ttttacctga atctgataca ggatctatat aactttacta ggacttttga ttgttgactc     3600

caggcttagg tatatcagaa ggttcttttt gccatttggc ctgtggatgt ctgagaagat     3660

cattcacaat acatgtaaaa ttcaggtagg cctaaggaaa ggccagcctg tagaaagcaa     3720

aatggcagtg tctgttctcc actgttggag gcattatgta atttaagtat cctgttagcc     3780

actgtctttc tgctaattaa gtggggctga acaagtaagc actaataata ccagtgaacc     3840

acttgggcac cttgtgggta gagttttgct gccacctagt ggaatgggat atcattgctt     3900

ccatatcagg ttcacaagca agttaagtgg gcacagttta tttctgtgta gctcaggctg     3960

taatcttgaa agctgaggag atacccatgc ctctcagact cattagctgg gtgtcacatt     4020

accacctgca cattctgacc caccgcatct taatatgttt tgtcctcttg gagaaactag     4080

gagtagaagt caggatatgg taggtaaggg ggaaaaagga aagacggctt gatagctatg     4140

aatgcatgag gagcgaaatg ttgactcagt tatctagatc atggtctcca aacctgatgc     4200

tatttcctta caaaaatatt tgttgagcat gtgtccataa ttatatgtat tgaacaatga     4260

aaatatgtgt caacaaatgt actgctacac taatgtgaac attatggaac aaaatttgaa     4320

agagtgaaat aaaaggttta cactttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa        4377


<210> 420
<211> 436
<212> PRT
<213> Homo sapiens

<400> 420
Met Ser Val Ser Ala Arg Ser Ala Ala Ala Glu Glu Arg Ser Val Asn 
1               5                   10                  15      


Ser Ser Thr Met Ala Gln Gln Lys Asn Leu Glu Gly Tyr Val Gly Phe 
            20                  25                  30          


Ala Asn Leu Pro Asn Gln Val Tyr Arg Lys Ser Val Lys Arg Gly Phe 
        35                  40                  45              


Glu Phe Thr Leu Met Val Val Gly Glu Ser Gly Leu Gly Lys Ser Thr 
    50                  55                  60                  


Leu Ile Asn Ser Leu Phe Leu Thr Asp Leu Tyr Ser Pro Glu Tyr Pro 
65                  70                  75                  80  


Gly Pro Ser His Arg Ile Lys Lys Thr Val Gln Val Glu Gln Ser Lys 
                85                  90                  95      


Val Leu Ile Lys Glu Gly Gly Val Gln Leu Leu Leu Thr Ile Val Asp 
            100                 105                 110         


Thr Pro Gly Phe Gly Asp Ala Val Asp Asn Ser Asn Cys Trp Gln Pro 
        115                 120                 125             


Val Ile Asp Tyr Ile Asp Ser Lys Phe Glu Asp Tyr Leu Asn Ala Glu 
    130                 135                 140                 


Ser Arg Val Asn Arg Arg Gln Met Pro Asp Asn Arg Val Gln Cys Cys 
145                 150                 155                 160 


Leu Tyr Phe Ile Ala Pro Ser Gly His Gly Leu Lys Pro Leu Asp Ile 
                165                 170                 175     


Glu Phe Met Lys Arg Leu His Glu Lys Val Asn Ile Ile Pro Leu Ile 
            180                 185                 190         


Ala Lys Ala Asp Thr Leu Thr Pro Glu Glu Cys Gln Gln Phe Lys Lys 
        195                 200                 205             


Gln Ile Met Lys Glu Ile Gln Glu His Lys Ile Lys Ile Tyr Glu Phe 
    210                 215                 220                 


Pro Glu Thr Asp Asp Glu Glu Glu Asn Lys Leu Val Lys Lys Ile Lys 
225                 230                 235                 240 


Asp Arg Leu Pro Leu Ala Val Val Gly Ser Asn Thr Ile Ile Glu Val 
                245                 250                 255     


Asn Gly Lys Arg Val Arg Gly Arg Gln Tyr Pro Trp Gly Val Ala Glu 
            260                 265                 270         


Val Glu Asn Gly Glu His Cys Asp Phe Thr Ile Leu Arg Asn Met Leu 
        275                 280                 285             


Ile Arg Thr His Met Gln Asp Leu Lys Asp Val Thr Asn Asn Val His 
    290                 295                 300                 


Tyr Glu Asn Tyr Arg Ser Arg Lys Leu Ala Ala Val Thr Tyr Asn Gly 
305                 310                 315                 320 


Val Asp Asn Asn Lys Asn Lys Gly Gln Leu Thr Lys Ser Pro Leu Ala 
                325                 330                 335     


Gln Met Glu Glu Glu Arg Arg Glu His Val Ala Lys Met Lys Lys Met 
            340                 345                 350         


Glu Met Glu Met Glu Gln Val Phe Glu Met Lys Val Lys Glu Lys Val 
        355                 360                 365             


Gln Lys Leu Lys Asp Ser Glu Ala Glu Leu Gln Arg Arg His Glu Gln 
    370                 375                 380                 


Met Lys Lys Asn Leu Glu Ala Gln His Lys Glu Leu Glu Glu Lys Arg 
385                 390                 395                 400 


Arg Gln Phe Glu Asp Glu Lys Ala Asn Trp Glu Ala Gln Gln Arg Ile 
                405                 410                 415     


Leu Glu Gln Gln Asn Ser Ser Arg Thr Leu Glu Lys Asn Lys Lys Lys 
            420                 425                 430         


Gly Lys Ile Phe 
        435     


<210> 421
<211> 2090
<212> DNA
<213> Homo sapiens

<400> 421
ttttagtctc cgcgtgaaaa ggtccttcat gctaatctaa ttcaattcag ttctcctttt       60

tctttcttct tctcctcgcc ctcttctcag ggaaggaatc gtcaaaaatc aatgtttcaa      120

cagatctcgc ggtgctattc gagattccct attaaaaaaa aatagaattg atgcaaacag      180

cctgttcctt ccggggtttt gggctggaac tgcagcgctt agagagctcg gtggaagctg      240

ctaaaggcgg aggcggggct ctggcgagtt ctccttccac cttcccccac ccttctctgc      300

caaccgctgt ttcagcccct agctggattc cagccattgc tgcagctgct ccacagccct      360

tttcaggacc caaacaaccg cagccgctgt tcccaggatg gtgatccgtg tatatattgc      420

atcttcctct ggctctacag cgattaagaa gaaacaacaa gatgtgcttg gtttcctaga      480

agccaacaaa ataggatttg aagaaaaaga tattgcagcc aatgaagaga atcggaagtg      540

gatgagagaa aatgtacctg aaaatagtcg accagccaca ggttaccccc tgccacctca      600

gattttcaat gaaagccagt atcgcgggga ctatgatgcc ttctttgaag ccagagaaaa      660

taatgcagtg tatgccttct taggcttgac agccccacct ggttcaaagg aagcagaagt      720

gcaagcaaag cagcaagcat gaaccttaag cactgtgctt taagcatcct gaaaaatgag      780

tctccattgc ttttataaaa tagcagaatt agctttgctt caaaagaaat aggcttaatg      840

ttgaaataat agattagttg ggttttcaca tgcaaacatt caaaatgaat acaaaattaa      900

aatttgaaca ttatggtgat tatggtgagg agaatgggat attaacataa aattatatta      960

ataagtagat atcgtagaaa tagtgttgtt acctgccaag ccatcctgta tacaccaatg     1020

attttacaaa gaaaacaccc ttccctcctt ctgccattac tatggcaact taagtgtatc     1080

tgcagctcta cattaaaaag gagaaagaga aataacctgt ctctcattcc taagttgcct     1140

cattaatttt catgaacaag aatatgtacc tttttgatgc tatattactg cgattaaaaa     1200

gttcttgcag gtaatgttta tgatatgtta aacgttgtaa tttcctatcg taattataac     1260

attcccattc ttttgtagat gaaacttcta catattgaac cacagatttt ctgagcttct     1320

aaatgtagcc tttcattgca catttcagtg atcagaatag atatcctttt acacgcacaa     1380

aagcaataga ttcattcagt ggacaagttc cttgtttaac tacacagcta tgatggaatg     1440

atatatccaa gttccttgcc tcagtgaaat atgcatatgt atatcatgaa agtgggatgc     1500

caagtaagct taaaatggca ttctctagca aagagattag acttttaaat aactcttata     1560

aaacaggttg gcgatcattt cccaagattg gtttcccttg agtttttgct aaaacaaatc     1620

ttagtagttt tgcccgttta aaacaactca caatcgtaaa tgctactatt cctaagatat     1680

cttacctttt tatttcagtt tagccatgta ttgtatgagt gtattagtct aagcagtgag     1740

aatcttttct atgcctctat tccagcaaaa agtagaagta tcaaataaaa agggcaactt     1800

ttaaaatatt aagcctgaag acttctaaaa agacaagaaa catggcctaa ataaccaaca     1860

tagatttaca tagtaagttt cacactacct tattaccaaa agcaaacacc tcttacttta     1920

aactacatta tcatgtatat ctattgtatg ctggtcttta ctttttgcca aaatcaacat     1980

ataatgaaga gatgcctttg tttcatgaga ttcaaacttg atgctatgct ttaaaataaa     2040

ctcagtactt ttagaaacat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                2090


<210> 422
<211> 114
<212> PRT
<213> Homo sapiens

<400> 422
Met Val Ile Arg Val Tyr Ile Ala Ser Ser Ser Gly Ser Thr Ala Ile 
1               5                   10                  15      


Lys Lys Lys Gln Gln Asp Val Leu Gly Phe Leu Glu Ala Asn Lys Ile 
            20                  25                  30          


Gly Phe Glu Glu Lys Asp Ile Ala Ala Asn Glu Glu Asn Arg Lys Trp 
        35                  40                  45              


Met Arg Glu Asn Val Pro Glu Asn Ser Arg Pro Ala Thr Gly Tyr Pro 
    50                  55                  60                  


Leu Pro Pro Gln Ile Phe Asn Glu Ser Gln Tyr Arg Gly Asp Tyr Asp 
65                  70                  75                  80  


Ala Phe Phe Glu Ala Arg Glu Asn Asn Ala Val Tyr Ala Phe Leu Gly 
                85                  90                  95      


Leu Thr Ala Pro Pro Gly Ser Lys Glu Ala Glu Val Gln Ala Lys Gln 
            100                 105                 110         


Gln Ala 
        


<210> 423
<211> 1153
<212> DNA
<213> Homo sapiens

<400> 423
aactccaggg ctagtgagct ggaccggaag taggtttcta cccgaccgca ttttacgtgg       60

tgctgcattt ccggtagcgg cggcgggaaa tcggctgtgg gagagaggct aggcctctga      120

ggaggcgaat ccggcgggta tcagagccat cagaaccgcc accatgacgg tgggcaagag      180

cagcaagatg ctgcagcata ttgattacag gatgaggtgc atcctgcagg acggccggat      240

cttcattggc accttcaagg cttttgacaa gcacatgaat ttgatcctct gtgactgtga      300

tgagttcaga aagatcaagc caaagaactc caaacaagca gaaagggaag agaagcgagt      360

cctcggtctg gtgctgctgc gaggggagaa tctggtctca atgacagtag agggacctcc      420

tcccaaagat actggtattg ctcgagttcc acttgctgga gctgccgggg gcccagggat      480

cggcagggct gctggcagag gaatcccagc tggggttccc atgccccagg ctcctgcagg      540

acttgctggg ccagtccgtg gggttggcgg gccatcccaa caggtgatga ccccacaagg      600

aagaggtact gttgcagccg ctgcagctgc tgccacagcc agtattgccg gggctccaac      660

ccagtaccca cctggccgtg ggggtcctcc cccacctatg ggccgaggag caccccctcc      720

aggcatgatg ggcccacctc ctggtatgag acctcctatg ggtcccccaa tggggatccc      780

ccctggaaga gggactccaa tgggcatgcc ccctccggga atgcggcctc ctccccctgg      840

gatgcgaggc cttctttgac ccttggccac agagtatgga agtagctccg cagaggcgtg      900

ggctcgattc ctcagggcca cgttaccaca gacctgtttg tttcttatgc tgttgttcgt      960

ggagtctcat gggattgtct ggtttccctt acagggcccc ctcccccggg aatgcgccca     1020

ccaaggccct agactcatct tggccctcct cagctccctg cctgtttccc gtaaggctgt     1080

acatagtcct tttatctcct tgtggcctat gaaactggtt tataataaac tcttaagaga     1140

acattataat tgc                                                        1153


<210> 424
<211> 231
<212> PRT
<213> Homo sapiens

<400> 424
Met Thr Val Gly Lys Ser Ser Lys Met Leu Gln His Ile Asp Tyr Arg 
1               5                   10                  15      


Met Arg Cys Ile Leu Gln Asp Gly Arg Ile Phe Ile Gly Thr Phe Lys 
            20                  25                  30          


Ala Phe Asp Lys His Met Asn Leu Ile Leu Cys Asp Cys Asp Glu Phe 
        35                  40                  45              


Arg Lys Ile Lys Pro Lys Asn Ser Lys Gln Ala Glu Arg Glu Glu Lys 
    50                  55                  60                  


Arg Val Leu Gly Leu Val Leu Leu Arg Gly Glu Asn Leu Val Ser Met 
65                  70                  75                  80  


Thr Val Glu Gly Pro Pro Pro Lys Asp Thr Gly Ile Ala Arg Val Pro 
                85                  90                  95      


Leu Ala Gly Ala Ala Gly Gly Pro Gly Ile Gly Arg Ala Ala Gly Arg 
            100                 105                 110         


Gly Ile Pro Ala Gly Val Pro Met Pro Gln Ala Pro Ala Gly Leu Ala 
        115                 120                 125             


Gly Pro Val Arg Gly Val Gly Gly Pro Ser Gln Gln Val Met Thr Pro 
    130                 135                 140                 


Gln Gly Arg Gly Thr Val Ala Ala Ala Ala Ala Ala Ala Thr Ala Ser 
145                 150                 155                 160 


Ile Ala Gly Ala Pro Thr Gln Tyr Pro Pro Gly Arg Gly Gly Pro Pro 
                165                 170                 175     


Pro Pro Met Gly Arg Gly Ala Pro Pro Pro Gly Met Met Gly Pro Pro 
            180                 185                 190         


Pro Gly Met Arg Pro Pro Met Gly Pro Pro Met Gly Ile Pro Pro Gly 
        195                 200                 205             


Arg Gly Thr Pro Met Gly Met Pro Pro Pro Gly Met Arg Pro Pro Pro 
    210                 215                 220                 


Pro Gly Met Arg Gly Leu Leu 
225                 230     


<210> 425
<211> 981
<212> DNA
<213> Homo sapiens

<400> 425
gtttggggcc agagtgggcg aggcgcggag gtctggccta taaagtagtc gcggagacgg       60

ggtgctggtt tgcgtcgtag tctcctgcag cgtctggggt ttccgttgca gtcctcggaa      120

ccaggacctc ggcgtggcct agcgagttat ggcgacgaag gccgtgtgcg tgctgaaggg      180

cgacggccca gtgcagggca tcatcaattt cgagcagaag gaaagtaatg gaccagtgaa      240

ggtgtgggga agcattaaag gactgactga aggcctgcat ggattccatg ttcatgagtt      300

tggagataat acagcaggct gtaccagtgc aggtcctcac tttaatcctc tatccagaaa      360

acacggtggg ccaaaggatg aagagaggca tgttggagac ttgggcaatg tgactgctga      420

caaagatggt gtggccgatg tgtctattga agattctgtg atctcactct caggagacca      480

ttgcatcatt ggccgcacac tggtggtcca tgaaaaagca gatgacttgg gcaaaggtgg      540

aaatgaagaa agtacaaaga caggaaacgc tggaagtcgt ttggcttgtg gtgtaattgg      600

gatcgcccaa taaacattcc cttggatgta gtctgaggcc ccttaactca tctgttatcc      660

tgctagctgt agaaatgtat cctgataaac attaaacact gtaatcttaa aagtgtaatt      720

gtgtgacttt ttcagagttg ctttaaagta cctgtagtga gaaactgatt tatgatcact      780

tggaagattt gtatagtttt ataaaactca gttaaaatgt ctgtttcaat gacctgtatt      840

ttgccagact taaatcacag atgggtatta aacttgtcag aatttctttg tcattcaagc      900

ctgtgaataa aaaccctgta tggcacttat tatgaggcta ttaaaagaat ccaaattcaa      960

actaaaaaaa aaaaaaaaaa a                                                981


<210> 426
<211> 154
<212> PRT
<213> Homo sapiens

<400> 426
Met Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln 
1               5                   10                  15      


Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val 
            20                  25                  30          


Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val 
        35                  40                  45              


His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His 
    50                  55                  60                  


Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg 
65                  70                  75                  80  


His Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala 
                85                  90                  95      


Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys 
            100                 105                 110         


Ile Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly 
        115                 120                 125             


Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg 
    130                 135                 140                 


Leu Ala Cys Gly Val Ile Gly Ile Ala Gln 
145                 150                 


<210> 427
<211> 2197
<212> DNA
<213> Homo sapiens

<400> 427
aaattaacgt actatcctcc ttacttttgg gtcgggccct ccgggaagat ggcggccgtg       60

caggcggccg aggtgaaagt ggatggcagc gagccgaaac tgagcaagaa gtggtggtaa      120

tcattagttc cagggtgctc tgccatgttg acgcaagctg ctgtaaggct tgttaggggg      180

tccctgcgca aaacctcctg ggcagagtgg ggtcacaggg aactgcgact gggtcaactt      240

gctcctttca cagcgcctca caaggacaag tcattttctg atcaaagaag tgagctgaag      300

agacgcctga aagctgagaa gaaagtagca gagaaggagg ccaaacagaa agagctcagt      360

gagaaacagc taagccaagc cactgctgct gccaccaacc acaccactga taatggtgtg      420

ggtcctgagg aagagagcgt ggacccaaat caatactaca aaatccgcag tcaagcaatt      480

catcagctga aggtcaatgg ggaagaccca tacccacaca agttccatgt agacatctca      540

ctcactgact tcatccaaaa atatagtcac ctgcagcctg gggatcacct gactgacatc      600

accttaaagg tggcaggtag gatccatgcc aaaagagctt ctgggggaaa gctcatcttc      660

tatgatcttc gaggagaggg ggtgaagttg caagtcatgg ccaattccag aaattataaa      720

tcagaagaag aatttattca tattaataac aaactgcgtc ggggagacat aattggagtt      780

caggggaatc ctggtaaaac caagaagggt gagctgagca tcattccgta tgagatcaca      840

ctgctgtctc cctgtttgca tatgttacct catcttcact ttggcctcaa agacaaggaa      900

acaaggtatc gccagagata cttggacttg atcctgaatg actttgtgag gcagaaattt      960

atcatccgct ctaagatcat cacatatata agaagtttct tagatgagct gggattccta     1020

gagattgaaa ctcccatgat gaacatcatc ccagggggag ccgtggccaa gcctttcatc     1080

acttatcaca acgagctgga catgaactta tatatgagaa ttgctccaga actctatcat     1140

aagatgcttg tggttggtgg catcgaccgg gtttatgaaa ttggacgcca gttccggaat     1200

gaggggattg atttgacgca caatcctgag ttcaccacct gtgagttcta catggcctat     1260

gcagactatc acgatctcat ggaaatcacg gagaagatgg tttcagggat ggtgaagcat     1320

attacaggca gttacaaggt cacctaccac ccagatggcc cagagggcca agcctacgat     1380

gttgacttca ccccaccctt ccggcgaatc aacatggtag aagagcttga gaaagccctg     1440

gggatgaagc tgccagaaac gaacctcttt gaaactgaag aaactcgcaa aattcttgat     1500

gatatctgtg tggcaaaagc tgttgaatgc cctccacctc ggaccacagc caggctcctt     1560

gacaagcttg ttggggagtt cctggaagtg acttgcatca atcctacatt catctgtgat     1620

cacccacaga taatgagccc tttggctaaa tggcaccgct ctaaagaggg tctgactgag     1680

cgctttgagc tgtttgtcat gaagaaagag atatgcaatg cgtatactga gctgaatgat     1740

cccatgcggc agcggcagct ttttgaagaa caggccaagg ccaaggctgc aggtgatgat     1800

gaggccatgt tcatagatga aaacttctgt actgccctgg aatatgggct gccccccaca     1860

gctggctggg gcatgggcat tgatcgagtc gccatgtttc tcacggactc caacaacatc     1920

aaggaagtac ttctgtttcc tgccatgaaa cccgaagaca agaaggagaa tgtagcaacc     1980

actgatacac tggaaagcac aacagttggc acttctgtct agaaaataat aattgcaagt     2040

tgtataactc aggcgtcttt gcatttctgc gaaagatcaa ggtctgcaag ggaattcttg     2100

tgtgctgctt tccatttgac accgcagttc tgttcagcca tcagaagaga gacaaggaat     2160

taaaaatttc tttttaatcc tgttaccaaa taaaaaa                              2197


<210> 428
<211> 625
<212> PRT
<213> Homo sapiens

<400> 428
Met Leu Thr Gln Ala Ala Val Arg Leu Val Arg Gly Ser Leu Arg Lys 
1               5                   10                  15      


Thr Ser Trp Ala Glu Trp Gly His Arg Glu Leu Arg Leu Gly Gln Leu 
            20                  25                  30          


Ala Pro Phe Thr Ala Pro His Lys Asp Lys Ser Phe Ser Asp Gln Arg 
        35                  40                  45              


Ser Glu Leu Lys Arg Arg Leu Lys Ala Glu Lys Lys Val Ala Glu Lys 
    50                  55                  60                  


Glu Ala Lys Gln Lys Glu Leu Ser Glu Lys Gln Leu Ser Gln Ala Thr 
65                  70                  75                  80  


Ala Ala Ala Thr Asn His Thr Thr Asp Asn Gly Val Gly Pro Glu Glu 
                85                  90                  95      


Glu Ser Val Asp Pro Asn Gln Tyr Tyr Lys Ile Arg Ser Gln Ala Ile 
            100                 105                 110         


His Gln Leu Lys Val Asn Gly Glu Asp Pro Tyr Pro His Lys Phe His 
        115                 120                 125             


Val Asp Ile Ser Leu Thr Asp Phe Ile Gln Lys Tyr Ser His Leu Gln 
    130                 135                 140                 


Pro Gly Asp His Leu Thr Asp Ile Thr Leu Lys Val Ala Gly Arg Ile 
145                 150                 155                 160 


His Ala Lys Arg Ala Ser Gly Gly Lys Leu Ile Phe Tyr Asp Leu Arg 
                165                 170                 175     


Gly Glu Gly Val Lys Leu Gln Val Met Ala Asn Ser Arg Asn Tyr Lys 
            180                 185                 190         


Ser Glu Glu Glu Phe Ile His Ile Asn Asn Lys Leu Arg Arg Gly Asp 
        195                 200                 205             


Ile Ile Gly Val Gln Gly Asn Pro Gly Lys Thr Lys Lys Gly Glu Leu 
    210                 215                 220                 


Ser Ile Ile Pro Tyr Glu Ile Thr Leu Leu Ser Pro Cys Leu His Met 
225                 230                 235                 240 


Leu Pro His Leu His Phe Gly Leu Lys Asp Lys Glu Thr Arg Tyr Arg 
                245                 250                 255     


Gln Arg Tyr Leu Asp Leu Ile Leu Asn Asp Phe Val Arg Gln Lys Phe 
            260                 265                 270         


Ile Ile Arg Ser Lys Ile Ile Thr Tyr Ile Arg Ser Phe Leu Asp Glu 
        275                 280                 285             


Leu Gly Phe Leu Glu Ile Glu Thr Pro Met Met Asn Ile Ile Pro Gly 
    290                 295                 300                 


Gly Ala Val Ala Lys Pro Phe Ile Thr Tyr His Asn Glu Leu Asp Met 
305                 310                 315                 320 


Asn Leu Tyr Met Arg Ile Ala Pro Glu Leu Tyr His Lys Met Leu Val 
                325                 330                 335     


Val Gly Gly Ile Asp Arg Val Tyr Glu Ile Gly Arg Gln Phe Arg Asn 
            340                 345                 350         


Glu Gly Ile Asp Leu Thr His Asn Pro Glu Phe Thr Thr Cys Glu Phe 
        355                 360                 365             


Tyr Met Ala Tyr Ala Asp Tyr His Asp Leu Met Glu Ile Thr Glu Lys 
    370                 375                 380                 


Met Val Ser Gly Met Val Lys His Ile Thr Gly Ser Tyr Lys Val Thr 
385                 390                 395                 400 


Tyr His Pro Asp Gly Pro Glu Gly Gln Ala Tyr Asp Val Asp Phe Thr 
                405                 410                 415     


Pro Pro Phe Arg Arg Ile Asn Met Val Glu Glu Leu Glu Lys Ala Leu 
            420                 425                 430         


Gly Met Lys Leu Pro Glu Thr Asn Leu Phe Glu Thr Glu Glu Thr Arg 
        435                 440                 445             


Lys Ile Leu Asp Asp Ile Cys Val Ala Lys Ala Val Glu Cys Pro Pro 
    450                 455                 460                 


Pro Arg Thr Thr Ala Arg Leu Leu Asp Lys Leu Val Gly Glu Phe Leu 
465                 470                 475                 480 


Glu Val Thr Cys Ile Asn Pro Thr Phe Ile Cys Asp His Pro Gln Ile 
                485                 490                 495     


Met Ser Pro Leu Ala Lys Trp His Arg Ser Lys Glu Gly Leu Thr Glu 
            500                 505                 510         


Arg Phe Glu Leu Phe Val Met Lys Lys Glu Ile Cys Asn Ala Tyr Thr 
        515                 520                 525             


Glu Leu Asn Asp Pro Met Arg Gln Arg Gln Leu Phe Glu Glu Gln Ala 
    530                 535                 540                 


Lys Ala Lys Ala Ala Gly Asp Asp Glu Ala Met Phe Ile Asp Glu Asn 
545                 550                 555                 560 


Phe Cys Thr Ala Leu Glu Tyr Gly Leu Pro Pro Thr Ala Gly Trp Gly 
                565                 570                 575     


Met Gly Ile Asp Arg Val Ala Met Phe Leu Thr Asp Ser Asn Asn Ile 
            580                 585                 590         


Lys Glu Val Leu Leu Phe Pro Ala Met Lys Pro Glu Asp Lys Lys Glu 
        595                 600                 605             


Asn Val Ala Thr Thr Asp Thr Leu Glu Ser Thr Thr Val Gly Thr Ser 
    610                 615                 620                 


Val 
625 


<210> 429
<211> 5905
<212> DNA
<213> Homo sapiens

<400> 429
ctcctcccgc accgccctgt cgcccaacgg cggcctcagg agtgatcggg cagcagtcgg       60

ccggccagcg gacggcagag cgggcggacg ggtaggcccg gcctgctctt cgcgaggagg      120

aagaaggtgg ccactctccc ggtccccaga acctccccag cccccgcagt ccgcccagac      180

cgtaaagggg gacgctgagg agccgcggac gctctccccg gtgccgccgc cgctgccgcc      240

gccatggctg ccatgatgga tcggaagtga gcattagggt taacggctgc cggcgccggc      300

tcttcaagtc ccggctcccc ggccgcctcc acccggggaa gcgcagcgcg gcgcagctga      360

ctgctgcctc tcacggccct cgcgaccaca agccctcagg tccggcgcgt tccctgcaag      420

actgagcggc ggggagtggc tcccggccgc cggccccggc tgcgagaaag atggcggacc      480

tggccgagtg caacatcaaa gtgatgtgtc gcttcagacc tctcaacgag tctgaagtga      540

accgcggcga caagtacatc gccaagtttc agggagaaga cacggtcgtg atcgcgtcca      600

agccttatgc atttgatcgg gtgttccagt caagcacatc tcaagagcaa gtgtataatg      660

actgtgcaaa gaagattgtt aaagatgtac ttgaaggata taatggaaca atatttgcat      720

atggacaaac atcctctggg aagacacaca caatggaggg taaacttcat gatccagaag      780

gcatgggaat tattccaaga atagtgcaag atatttttaa ttatatttac tccatggatg      840

aaaatttgga atttcatatt aaggtttcat attttgaaat atatttggat aagataaggg      900

acctgttaga tgtttcaaag accaaccttt cagttcatga agacaaaaac cgagttccct      960

atgtaaaggg gtgcacagag cgttttgtat gtagtccaga tgaagttatg gataccatag     1020

atgaaggaaa atccaacaga catgtagcag ttacaaatat gaatgaacat agctctagga     1080

gtcacagtat atttcttatt aatgtcaaac aagagaacac acaaacggaa caaaagctga     1140

gtggaaaact ttatctggtt gatttagctg gtagtgaaaa ggttagtaaa actggagctg     1200

aaggtgctgt gctggatgaa gctaaaaaca tcaacaagtc actttctgct cttggaaatg     1260

ttatttctgc tttggctgag ggtagtacat atgttccata tcgagatagt aaaatgacaa     1320

gaatccttca agattcatta ggtggcaact gtagaaccac tattgtaatt tgctgctctc     1380

catcatcata caatgagtct gaaacaaaat ctacactctt atttggccaa agggccaaaa     1440

caattaagaa cacagtttgt gtcaatgtgg agttaactgc agaacagtgg aaaaagaagt     1500

atgaaaaaga aaaagaaaaa aataagatcc tgcggaacac tattcagtgg cttgaaaatg     1560

agctcaacag atggcgtaat ggggagacgg tgcctattga tgaacagttt gacaaagaga     1620

aagccaactt ggaagctttc acagtggata aagatattac tcttaccaat gataaaccag     1680

caaccgcaat tggagttata ggaaatttta ctgatgctga aagaagaaag tgtgaagaag     1740

aaattgctaa attatacaaa cagcttgatg acaaggatga agaaattaac cagcaaagtc     1800

aactggtaga gaaactgaag acgcaaatgt tggatcagga ggagcttttg gcatctacca     1860

gaagggatca agacaatatg caagctgagc tgaatcgcct tcaagcagaa aatgatgcct     1920

ctaaagaaga agtgaaagaa gttttacagg ccctagaaga acttgctgtc aattatgatc     1980

agaagtctca ggaagttgaa gacaaaacta aggaatatga attgcttagt gatgaattga     2040

atcagaaatc ggcaacttta gcgagtatag atgctgagct tcagaaactt aaggaaatga     2100

ccaaccacca gaaaaaacga gcagctgaga tgatggcatc tttactaaaa gaccttgcag     2160

aaataggaat tgctgtggga aataatgatg taaagcagcc tgagggaact ggcatgatag     2220

atgaagagtt cactgttgca agactctaca ttagcaaaat gaagtcagaa gtaaaaacca     2280

tggtgaaacg ttgcaagcag ttagaaagca cacaaactga gagcaacaaa aaaatggaag     2340

aaaatgaaaa ggagttagca gcatgtcagc ttcgtatctc tcaacatgaa gccaaaatca     2400

agtcattgac tgaatacctt caaaatgtgg aacaaaagaa aagacagttg gaggaatctg     2460

tcgatgccct cagtgaagaa ctagtccagc ttcgagcaca agagaaagtc catgaaatgg     2520

aaaaggagca cttaaataag gttcagactg caaatgaagt taagcaagct gttgaacagc     2580

agatccagag ccatagagaa actcatcaaa aacagatcag tagtttgaga gatgaagtag     2640

aagcaaaagc aaaacttatt actgatcttc aagaccaaaa ccagaaaatg atgttagagc     2700

aggaacgtct aagagtagaa catgagaagt tgaaagccac agatcaggaa aagagcagaa     2760

aactacatga acttacggtt atgcaagata gacgagaaca agcaagacaa gacttgaagg     2820

gtttggaaga gacagtggca aaagaacttc agactttaca caacctgcgc aaactctttg     2880

ttcaggacct ggctacaaga gttaaaaaga gtgctgagat tgattctgat gacaccggag     2940

gcagcgctgc tcagaagcaa aaaatctcct ttcttgaaaa taatcttgaa cagctcacta     3000

aagtgcacaa acagttggta cgtgataatg cagatctccg ctgtgaactt cctaagttgg     3060

aaaagcgact tcgagctaca gctgagagag tgaaagcttt ggaatcagca ctgaaagaag     3120

ctaaagaaaa tgcatctcgt gatcgcaaac gctatcagca agaagtagat cgcataaagg     3180

aagcagtcag gtcaaagaat atggccagaa gagggcattc tgcacagatt gctaaaccta     3240

ttcgtcccgg gcaacatcca gcagcttctc caactcaccc aagtgcaatt cgtggaggag     3300

gtgcatttgt tcagaacagc cagccagtgg cagtgcgagg tggaggaggc aaacaagtgt     3360

aatcgtttat acatacccac aggtgttaaa aagtaatcga agtacgaaga ggacatggta     3420

tcaagcagtc attcaatgac tataacctct actcccttgg gattgtagaa ttataacttt     3480

taaaaaaaat gtataaatta tacctggcct gtacagctgt ttcctaccta ctcttcttgt     3540

aaactctgct gcttcccaac acaactagag tgcaattttg gcatcttagg agggaaaaag     3600

gacagtttac aactgtggcc ctatttatta cacagtttgt ctatcgtgtc ttaaatttag     3660

tctttactgt gccaagctaa ctgtacctta taggactgta ctttttgtat tttttgtgta     3720

tgtttatttt ttaatctcag tttaaattac ctagctgcta ctgcttcttg tttttctttt     3780

cctattaaaa cgtcttcctt tttttttctt aagagaaaat ggaacattta ggttaaatgt     3840

ctttaaattt taccacttaa caacactaca tgcccataaa atatatccag tcagtactgt     3900

attttaaaat cccttgaaat gatgatatca gggttaaaat tacttgtatt gtttctgaag     3960

tttgctcctg aaaactactg tttgagcact gaaacgttac aaatgcctaa taggcatttg     4020

agactgagca aggctacttg ttatctcatg aaatgcctgt tgccgagtta ttttgaatag     4080

aaatatttta aagtatcaaa agcagatctt agtttaaggg agtttggaaa aggaattata     4140

tttctctttt tcctgattct gtactcaaca agtcttgatg gaattaaaat actctgcttt     4200

attctggtga gcctgctagc taatataagt attggacagg taataatttg tcatctttaa     4260

tattagtaaa atgaattaag atattatagg attaaacata attttatacg gttagtactt     4320

tattggccga cctaaattta tagcgtgtgg aaattgagaa aaatgaagaa acaggacaga     4380

tatatgatga attaaaaata tatataggtc aattttggtc tgaaatccct gaggtgtttt     4440

taacctgcta cactaatttg tacactaatt tatttcttta gtctagaaat agtaaattgt     4500

ttgcaagtca ctaataatca ttagataaat tattttcttg gccatagccg ataattttgt     4560

aatcagtact aagtgtatac gtatttttgc cactttttcc tcagatgatt aaagtaagtc     4620

aacagcttat tttaggaaac tgtaaaagta atagggaaag agatttcact atttgcttca     4680

tcagtggtag gggggcggtg actgcaactg tgttagcaga aattcacaga gaatggggat     4740

ttaaggttag cagagaaact tggaaagttc tgtgttagga tcttgctggc agaattaact     4800

ttttgcaaaa gttttataca cagatatttg tattaaattt ggagccatag tcagaagact     4860

cagatcataa ttggcttatt tttctatttc cgtaactatt gtaatttcca cttttgtaat     4920

aattttgatt taaaatataa atttatttat ttattttttt aatagtcaaa aatctttgct     4980

gttgtagtct gcaacctcta aaatgattgt gttgctttta ggattgatca gaagaaacac     5040

tccaaaaatt gagatgaaat gttggtgcag ccagttataa gtaatatagt taacaagcaa     5100

aaaaagtgct gccacctttt atgatgattt tctaaatgga gaaacatttg gctgcatcca     5160

catagacctt tatgttttgt tttcagttga aaacttgcct cctttggcaa cattcgtaaa     5220

tgaagcagaa tttttttttc tcttttttcc aaatatgtta gttttgttct tgtaagatgt     5280

atcatgggta ttggtgctgt gtaatgaaca acgaatttta attagcatgt ggttcagaat     5340

atacaatgtt aggtttttaa aaagtatctt gatggttctt ttctatttat aatttcagac     5400

tttcataaag tgtaccaaga atttcataaa tttgttttca gtgaactgct ttttgctatg     5460

gtaggtcatt aaacacagca cttactctta aaaatgaaaa tttctgatca tctaggatat     5520

tgacacattt caatttgcag tgtctttttg actggatata ttaacgttcc tctgaatggc     5580

attgatagat ggttcagaag agaaactcaa tgaaataaag agaatattta ttcatggcga     5640

ttaattaaat tatttgccta acttaagaaa actactgtgc gtaactctca gtttgtgctt     5700

aactccattt gacatgaggt gacagaagag agtctgagtc tacctgtgga atatgttggt     5760

ttattttcag tgcttgaaga tacattcaca aatacttggt ttgggaagac accgtttaat     5820

tttaagttaa cttgcatgtt gtaaatgcgt tttatgttta aataaagagg aaaatttttt     5880

gaaatgtaaa aaaaaaaaaa aaaaa                                           5905


<210> 430
<211> 963
<212> PRT
<213> Homo sapiens

<400> 430
Met Ala Asp Leu Ala Glu Cys Asn Ile Lys Val Met Cys Arg Phe Arg 
1               5                   10                  15      


Pro Leu Asn Glu Ser Glu Val Asn Arg Gly Asp Lys Tyr Ile Ala Lys 
            20                  25                  30          


Phe Gln Gly Glu Asp Thr Val Val Ile Ala Ser Lys Pro Tyr Ala Phe 
        35                  40                  45              


Asp Arg Val Phe Gln Ser Ser Thr Ser Gln Glu Gln Val Tyr Asn Asp 
    50                  55                  60                  


Cys Ala Lys Lys Ile Val Lys Asp Val Leu Glu Gly Tyr Asn Gly Thr 
65                  70                  75                  80  


Ile Phe Ala Tyr Gly Gln Thr Ser Ser Gly Lys Thr His Thr Met Glu 
                85                  90                  95      


Gly Lys Leu His Asp Pro Glu Gly Met Gly Ile Ile Pro Arg Ile Val 
            100                 105                 110         


Gln Asp Ile Phe Asn Tyr Ile Tyr Ser Met Asp Glu Asn Leu Glu Phe 
        115                 120                 125             


His Ile Lys Val Ser Tyr Phe Glu Ile Tyr Leu Asp Lys Ile Arg Asp 
    130                 135                 140                 


Leu Leu Asp Val Ser Lys Thr Asn Leu Ser Val His Glu Asp Lys Asn 
145                 150                 155                 160 


Arg Val Pro Tyr Val Lys Gly Cys Thr Glu Arg Phe Val Cys Ser Pro 
                165                 170                 175     


Asp Glu Val Met Asp Thr Ile Asp Glu Gly Lys Ser Asn Arg His Val 
            180                 185                 190         


Ala Val Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ser Ile Phe 
        195                 200                 205             


Leu Ile Asn Val Lys Gln Glu Asn Thr Gln Thr Glu Gln Lys Leu Ser 
    210                 215                 220                 


Gly Lys Leu Tyr Leu Val Asp Leu Ala Gly Ser Glu Lys Val Ser Lys 
225                 230                 235                 240 


Thr Gly Ala Glu Gly Ala Val Leu Asp Glu Ala Lys Asn Ile Asn Lys 
                245                 250                 255     


Ser Leu Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Ala Glu Gly Ser 
            260                 265                 270         


Thr Tyr Val Pro Tyr Arg Asp Ser Lys Met Thr Arg Ile Leu Gln Asp 
        275                 280                 285             


Ser Leu Gly Gly Asn Cys Arg Thr Thr Ile Val Ile Cys Cys Ser Pro 
    290                 295                 300                 


Ser Ser Tyr Asn Glu Ser Glu Thr Lys Ser Thr Leu Leu Phe Gly Gln 
305                 310                 315                 320 


Arg Ala Lys Thr Ile Lys Asn Thr Val Cys Val Asn Val Glu Leu Thr 
                325                 330                 335     


Ala Glu Gln Trp Lys Lys Lys Tyr Glu Lys Glu Lys Glu Lys Asn Lys 
            340                 345                 350         


Ile Leu Arg Asn Thr Ile Gln Trp Leu Glu Asn Glu Leu Asn Arg Trp 
        355                 360                 365             


Arg Asn Gly Glu Thr Val Pro Ile Asp Glu Gln Phe Asp Lys Glu Lys 
    370                 375                 380                 


Ala Asn Leu Glu Ala Phe Thr Val Asp Lys Asp Ile Thr Leu Thr Asn 
385                 390                 395                 400 


Asp Lys Pro Ala Thr Ala Ile Gly Val Ile Gly Asn Phe Thr Asp Ala 
                405                 410                 415     


Glu Arg Arg Lys Cys Glu Glu Glu Ile Ala Lys Leu Tyr Lys Gln Leu 
            420                 425                 430         


Asp Asp Lys Asp Glu Glu Ile Asn Gln Gln Ser Gln Leu Val Glu Lys 
        435                 440                 445             


Leu Lys Thr Gln Met Leu Asp Gln Glu Glu Leu Leu Ala Ser Thr Arg 
    450                 455                 460                 


Arg Asp Gln Asp Asn Met Gln Ala Glu Leu Asn Arg Leu Gln Ala Glu 
465                 470                 475                 480 


Asn Asp Ala Ser Lys Glu Glu Val Lys Glu Val Leu Gln Ala Leu Glu 
                485                 490                 495     


Glu Leu Ala Val Asn Tyr Asp Gln Lys Ser Gln Glu Val Glu Asp Lys 
            500                 505                 510         


Thr Lys Glu Tyr Glu Leu Leu Ser Asp Glu Leu Asn Gln Lys Ser Ala 
        515                 520                 525             


Thr Leu Ala Ser Ile Asp Ala Glu Leu Gln Lys Leu Lys Glu Met Thr 
    530                 535                 540                 


Asn His Gln Lys Lys Arg Ala Ala Glu Met Met Ala Ser Leu Leu Lys 
545                 550                 555                 560 


Asp Leu Ala Glu Ile Gly Ile Ala Val Gly Asn Asn Asp Val Lys Gln 
                565                 570                 575     


Pro Glu Gly Thr Gly Met Ile Asp Glu Glu Phe Thr Val Ala Arg Leu 
            580                 585                 590         


Tyr Ile Ser Lys Met Lys Ser Glu Val Lys Thr Met Val Lys Arg Cys 
        595                 600                 605             


Lys Gln Leu Glu Ser Thr Gln Thr Glu Ser Asn Lys Lys Met Glu Glu 
    610                 615                 620                 


Asn Glu Lys Glu Leu Ala Ala Cys Gln Leu Arg Ile Ser Gln His Glu 
625                 630                 635                 640 


Ala Lys Ile Lys Ser Leu Thr Glu Tyr Leu Gln Asn Val Glu Gln Lys 
                645                 650                 655     


Lys Arg Gln Leu Glu Glu Ser Val Asp Ala Leu Ser Glu Glu Leu Val 
            660                 665                 670         


Gln Leu Arg Ala Gln Glu Lys Val His Glu Met Glu Lys Glu His Leu 
        675                 680                 685             


Asn Lys Val Gln Thr Ala Asn Glu Val Lys Gln Ala Val Glu Gln Gln 
    690                 695                 700                 


Ile Gln Ser His Arg Glu Thr His Gln Lys Gln Ile Ser Ser Leu Arg 
705                 710                 715                 720 


Asp Glu Val Glu Ala Lys Ala Lys Leu Ile Thr Asp Leu Gln Asp Gln 
                725                 730                 735     


Asn Gln Lys Met Met Leu Glu Gln Glu Arg Leu Arg Val Glu His Glu 
            740                 745                 750         


Lys Leu Lys Ala Thr Asp Gln Glu Lys Ser Arg Lys Leu His Glu Leu 
        755                 760                 765             


Thr Val Met Gln Asp Arg Arg Glu Gln Ala Arg Gln Asp Leu Lys Gly 
    770                 775                 780                 


Leu Glu Glu Thr Val Ala Lys Glu Leu Gln Thr Leu His Asn Leu Arg 
785                 790                 795                 800 


Lys Leu Phe Val Gln Asp Leu Ala Thr Arg Val Lys Lys Ser Ala Glu 
                805                 810                 815     


Ile Asp Ser Asp Asp Thr Gly Gly Ser Ala Ala Gln Lys Gln Lys Ile 
            820                 825                 830         


Ser Phe Leu Glu Asn Asn Leu Glu Gln Leu Thr Lys Val His Lys Gln 
        835                 840                 845             


Leu Val Arg Asp Asn Ala Asp Leu Arg Cys Glu Leu Pro Lys Leu Glu 
    850                 855                 860                 


Lys Arg Leu Arg Ala Thr Ala Glu Arg Val Lys Ala Leu Glu Ser Ala 
865                 870                 875                 880 


Leu Lys Glu Ala Lys Glu Asn Ala Ser Arg Asp Arg Lys Arg Tyr Gln 
                885                 890                 895     


Gln Glu Val Asp Arg Ile Lys Glu Ala Val Arg Ser Lys Asn Met Ala 
            900                 905                 910         


Arg Arg Gly His Ser Ala Gln Ile Ala Lys Pro Ile Arg Pro Gly Gln 
        915                 920                 925             


His Pro Ala Ala Ser Pro Thr His Pro Ser Ala Ile Arg Gly Gly Gly 
    930                 935                 940                 


Ala Phe Val Gln Asn Ser Gln Pro Val Ala Val Arg Gly Gly Gly Gly 
945                 950                 955                 960 


Lys Gln Val 
            


<210> 431
<211> 4478
<212> DNA
<213> Homo sapiens

<400> 431
gccccgcgcc tgaggggcag taaaagtcgc caggtccggc tccatttctg gcacaaaact       60

tgcagcaccg aggggttgtg gagagccctt gcaggggaag agggcagggt catcccgaga      120

accaacgggc acgtatagcc cggcgaacgc ccaagccggt caccgccccc ggtcacgtgt      180

cgccagcctc cgcggccgcg cgccgctctc agcaccgttc ccgccccacc cggcccggca      240

gtcggcccgc gcctcccccg gcgctactgc cacctcgcgc tcggaggcgt cacagaacgt      300

gctcttctct cccctccccc ctcccgctct ccccctcctc cccctcccgc tccaagattc      360

gccgccgccg ccgccgcagc cgcaggagta gccgccgccg gagccgcgcg cagccatggc      420

cgagaacccc agcttggaga accaccgcat caagagcttc aagaacaagg gccgcgatgt      480

ggaaacaatg cgaagacata gaaatgaagt gacagtggaa ctgcggaaga acaaaagaga      540

tgaacactta ttgaaaaaga gaaatgttcc ccaagaagaa agtctagaag attcagatgt      600

tgatgctgat tttaaagcac aaaatgtaac cctagaagct atattgcaga atgccacaag      660

tgataaccca gtggtccaat tgagtgctgt ccaggcagca agaaaactgt tatccagtga      720

cagaaatcca ccgattgatg acttaataaa atctgggatt ttaccaattc tagtcaaatg      780

tctagaaagg gatgataatc cttcattaca gtttgaagct gcttgggcat taactaacat      840

agcatcagga acttctgcac agactcaagc tgttgtgcag tctaatgcag tacctctttt      900

tctgagactt cttcgttcac cacatcagaa tgtttgtgaa caagcagtat gggctttggg      960

aaacattata ggtgatggtc ctcaatgtag agattatgtc atatcactgg gagttgtcaa     1020

acctcttctg tccttcatca gtccctccat ccccatcacc ttccttcgga acgtcacatg     1080

ggtcattgtc aatctctgca ggaataagga tcccccgccg cctatggaga cagttcagga     1140

gattttgcca gctttatgtg tcctcatata ccatacagat ataaacattc ttgtagacac     1200

tgtttgggct ctgtcatact tgacagatgg aggtaatgaa cagatacaga tggttattga     1260

ttcaggagtt gtgccctttc ttgtgcccct tctgagccat caggaagtca aagttcaaac     1320

agcagccctc agagcagttg gcaacatagt gactggcacc gacgagcaga cccaggttgt     1380

tctcaattgt gatgtcctgt cacacttccc aaatctctta tcacacccaa aagagaagat     1440

aaataaggaa gcagtgtggt tcctttccaa cataacagca ggcaaccagc aacaagttca     1500

agctgtaata gatgctggat taattcctat gataattcat cagcttgcta agggggactt     1560

tggaacacaa aaagaagctg cttgggcaat cagcaactta acaataagtg gcagaaaaga     1620

tcaggttgag taccttgtac agcagaatgt aataccaccg ttctgtaatt tactgtcagt     1680

gaaagattct caagtggttc aggtggttct agatggtcta aaaaacattc tgataatggc     1740

cggtgatgaa gcaagcacaa tagctgaaat aatagaggaa tgtggaggtt tggagaaaat     1800

tgaagtttta cagcaacatg aaaatgaaga catatataaa ttagcatttg aaatcataga     1860

tcagtatttc tctggtgatg atattgatga agatccctgc ctcattcctg aagcaacaca     1920

aggaggtacc tacaattttg atccaacagc caaccttcaa acaaaagaat ttaattttta     1980

aattcagttg agtgcagcat ctttcccaca ttcaatatga agcaccacca gatggctacc     2040

aaatgataag aacaacagca acaaaaggct ccaaaacaca catgcctctt tgttttgatg     2100

cttctaaagc aagccatgtc tcagtcactt tgcagttgcc aaaagtcact atcacatgga     2160

ctgtaaatgc atatgcatga tttcctaaac tgttttagaa ctctccttaa caatctcaac     2220

taccctattt ttccctgttc cctggtgcca caggctgaca actgcagtct ccagtttaga     2280

ataaatattc catagtggtg acatgtcagc tgcccactga tactcctttg gaaaatggtg     2340

cgctgtggat caagacactt tggtatgatg catatacaag ttggaagact aaagaggtgc     2400

agtgtgatct gagcctccat cattgtcctc cacaaacata ttttcatatt ctttatgtgg     2460

aagaatagat tttaaagtac aagccaaatg attttcattg gtggaactga cacaaaaaaa     2520

gtaacttaaa aacaagaaac ttggttattg aataaacaga taagtttaaa aaaaaaaaaa     2580

aactacttca tctaccagta attgatgtgt ttattatctg cctcagaagc cagggttgga     2640

ggaagaactt tagatatgga tattaatgct tttgccatta tacctaattt ttgagaacag     2700

caagccctat ttgaccactc tcttcagcct gtgtgttcct gctgttttga agtaatcaaa     2760

tgctgtgcat ggtattttac ctgagctgca acctgttatg gacttgaact tctgtttaag     2820

ttgaaagcaa gagtccctga gtataaagga aaaacagcaa aacaaaaagc aaacaaaaaa     2880

aaactgcaaa agtctaaaat acccattggt gatgtttttt aaaaaaatct tgctttcagc     2940

tttcaggagt taatattctt tgttttaatt tgataattgg atatggttga tttatattgg     3000

gtttaaactg tggagctttc atgtttactg taatttagtc ttaaaatatt ttttacttag     3060

taaccagtgc ttttgataat gtggttggca acaaaccagc aactatttag aagtgtcata     3120

agagttcatt ctttgagtat tgggaaagtt aattcagatc ctactcaaaa agcatcttca     3180

catattaaaa gattcagaca gggatctgtg tagaggagta atttgcagtt atttaacata     3240

aacctgattt gcagtgatct ctaagtaatt ctgcaaaatc cggtattact atgtcaagtt     3300

attgcttttg gtaaattgtc tgacccagtt attaatgaaa gaatatggat ttaaaaattt     3360

ttaaactaaa taatttgtgc tgtcacagaa atggtattgt tgctcttgtt tactgggtat     3420

aatttcccaa tgcattgatg tgaagggata gaaaatctaa actaatttag ttatccattg     3480

gggggtgtat ttactgtgat gaagatgaga cagatgccat cagagctttg tgaatcagct     3540

ggggtgtttt cactgataaa caacacatag caggtgtgca ttcattacaa atatatgtat     3600

ctgccaaggt ggagccactt taaagagtga gttttgtctt gtatctaaag tggatacaag     3660

cgtatgttta aactgcaaga tttttacttg ctagagaatc tgttttaata tagtggtttg     3720

gcctctgatt atttataggt tttataaatt ttagaatcaa tttctcttta aggtggctca     3780

gatttttcaa ctcttgtgca cataaaattg agttgaagtt cattgtgcct ttttttcttt     3840

atccaaattt tgagttaaag cttcatatgg taactgcatc ctgttcggac actatagtct     3900

aaatttttga aactgtgtgg tgttcgctaa aagtaggaat aacaacgtaa aagctaatta     3960

aggtcacaaa cttcggtgaa acccttaaaa gtccaaatct tcttgatatt gtgaaccgta     4020

ccccttccag tttagtttct tctggacttt ccttacttaa ctgacagtta ccttttaaaa     4080

tttgcacaca ttatgattaa aattgggcct ctactgtgat gattcctatt tcctctcatg     4140

ttttaaagtg caaactaaca tttaagtgaa cattagcatc aagtagtgca gacacttgta     4200

tgcatttcct tgattcaatt tgtgacctta ccagttttga attggaattg caccatttcg     4260

tagataaagg aaactaagta tattgctgca cttttaagtt ttcaaaacag tgtttaaaaa     4320

ttgcattgtt attttttttt aaactcagtt taaaaagact aaaacgttct ttcaaaagag     4380

gcatctaaat gtgttcctaa ttttgtatat gggcttaggt tttgtaacca ataaaaaaag     4440

ctgctatcaa atatgataaa acattgaaaa cttaaaaa                             4478


<210> 432
<211> 521
<212> PRT
<213> Homo sapiens

<400> 432
Met Ala Glu Asn Pro Ser Leu Glu Asn His Arg Ile Lys Ser Phe Lys 
1               5                   10                  15      


Asn Lys Gly Arg Asp Val Glu Thr Met Arg Arg His Arg Asn Glu Val 
            20                  25                  30          


Thr Val Glu Leu Arg Lys Asn Lys Arg Asp Glu His Leu Leu Lys Lys 
        35                  40                  45              


Arg Asn Val Pro Gln Glu Glu Ser Leu Glu Asp Ser Asp Val Asp Ala 
    50                  55                  60                  


Asp Phe Lys Ala Gln Asn Val Thr Leu Glu Ala Ile Leu Gln Asn Ala 
65                  70                  75                  80  


Thr Ser Asp Asn Pro Val Val Gln Leu Ser Ala Val Gln Ala Ala Arg 
                85                  90                  95      


Lys Leu Leu Ser Ser Asp Arg Asn Pro Pro Ile Asp Asp Leu Ile Lys 
            100                 105                 110         


Ser Gly Ile Leu Pro Ile Leu Val Lys Cys Leu Glu Arg Asp Asp Asn 
        115                 120                 125             


Pro Ser Leu Gln Phe Glu Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser 
    130                 135                 140                 


Gly Thr Ser Ala Gln Thr Gln Ala Val Val Gln Ser Asn Ala Val Pro 
145                 150                 155                 160 


Leu Phe Leu Arg Leu Leu Arg Ser Pro His Gln Asn Val Cys Glu Gln 
                165                 170                 175     


Ala Val Trp Ala Leu Gly Asn Ile Ile Gly Asp Gly Pro Gln Cys Arg 
            180                 185                 190         


Asp Tyr Val Ile Ser Leu Gly Val Val Lys Pro Leu Leu Ser Phe Ile 
        195                 200                 205             


Ser Pro Ser Ile Pro Ile Thr Phe Leu Arg Asn Val Thr Trp Val Ile 
    210                 215                 220                 


Val Asn Leu Cys Arg Asn Lys Asp Pro Pro Pro Pro Met Glu Thr Val 
225                 230                 235                 240 


Gln Glu Ile Leu Pro Ala Leu Cys Val Leu Ile Tyr His Thr Asp Ile 
                245                 250                 255     


Asn Ile Leu Val Asp Thr Val Trp Ala Leu Ser Tyr Leu Thr Asp Gly 
            260                 265                 270         


Gly Asn Glu Gln Ile Gln Met Val Ile Asp Ser Gly Val Val Pro Phe 
        275                 280                 285             


Leu Val Pro Leu Leu Ser His Gln Glu Val Lys Val Gln Thr Ala Ala 
    290                 295                 300                 


Leu Arg Ala Val Gly Asn Ile Val Thr Gly Thr Asp Glu Gln Thr Gln 
305                 310                 315                 320 


Val Val Leu Asn Cys Asp Val Leu Ser His Phe Pro Asn Leu Leu Ser 
                325                 330                 335     


His Pro Lys Glu Lys Ile Asn Lys Glu Ala Val Trp Phe Leu Ser Asn 
            340                 345                 350         


Ile Thr Ala Gly Asn Gln Gln Gln Val Gln Ala Val Ile Asp Ala Gly 
        355                 360                 365             


Leu Ile Pro Met Ile Ile His Gln Leu Ala Lys Gly Asp Phe Gly Thr 
    370                 375                 380                 


Gln Lys Glu Ala Ala Trp Ala Ile Ser Asn Leu Thr Ile Ser Gly Arg 
385                 390                 395                 400 


Lys Asp Gln Val Glu Tyr Leu Val Gln Gln Asn Val Ile Pro Pro Phe 
                405                 410                 415     


Cys Asn Leu Leu Ser Val Lys Asp Ser Gln Val Val Gln Val Val Leu 
            420                 425                 430         


Asp Gly Leu Lys Asn Ile Leu Ile Met Ala Gly Asp Glu Ala Ser Thr 
        435                 440                 445             


Ile Ala Glu Ile Ile Glu Glu Cys Gly Gly Leu Glu Lys Ile Glu Val 
    450                 455                 460                 


Leu Gln Gln His Glu Asn Glu Asp Ile Tyr Lys Leu Ala Phe Glu Ile 
465                 470                 475                 480 


Ile Asp Gln Tyr Phe Ser Gly Asp Asp Ile Asp Glu Asp Pro Cys Leu 
                485                 490                 495     


Ile Pro Glu Ala Thr Gln Gly Gly Thr Tyr Asn Phe Asp Pro Thr Ala 
            500                 505                 510         


Asn Leu Gln Thr Lys Glu Phe Asn Phe 
        515                 520     


<210> 433
<211> 586
<212> DNA
<213> Homo sapiens

<400> 433
agttaaaagg gtgggagcgt ccgggggccc atctctctcg ggtggagtct tctgacagct       60

ggtgcgcctg cccgggaaca tcctcctgga ctcaatcatg gcttgtggtc tggtcgccag      120

caacctgaat ctcaaacctg gagagtgcct tcgagtgcga ggcgaggtgg ctcctgacgc      180

taagagcttc gtgctgaacc tgggcaaaga cagcaacaac ctgtgcctgc acttcaaccc      240

tcgcttcaac gcccacggcg acgccaacac catcgtgtgc aacagcaagg acggcggggc      300

ctgggggacc gagcagcggg aggctgtctt tcccttccag cctggaagtg ttgcagaggt      360

gtgcatcacc ttcgaccagg ccaacctgac cgtcaagctg ccagatggat acgaattcaa      420

gttccccaac cgcctcaacc tggaggccat caactacatg gcagctgacg gtgacttcaa      480

gatcaaatgt gtggcctttg actgaaatca gccagcccat ggcccccaat aaaggcagct      540

gcctctgctc cctctgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                     586


<210> 434
<211> 135
<212> PRT
<213> Homo sapiens

<400> 434
Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210> 435
<211> 17928
<212> DNA
<213> Homo sapiens

<400> 435
attgtgggag ccgctcccct cggctccgcc acgctcccct cgactgcgct ccagcctggg       60

gcgcgcccgg ccgccgccgc cttcgctgcc gccacgggcc cgtcttcttc ctccttcggc      120

tcccaggatg aagaaactga gtctcagaga ggtgaagtga cttgcccaag atcacagcaa      180

ttatcacttc tccctgggct cccaggccct cctgcagcag cccccgcctg ggccatgtct      240

tcctcagatg aagagacgct cagtgagcgg tcatgtcgga gtgagcggtc ttgtcggagt      300

gagcgatctt acaggagcga gcggtcgggg agcctgtctc cctgtccccc aggggacacc      360

ttgccctgga acctgccact gcatgagcag aaaaagcgga aaagccagga ttcggtgctg      420

gaccctgcag agcgtgctgt ggtcagagtc gctgatgaac gggaccgggt tcagaagaaa      480

acgttcacca agtgggtcaa caagcactta atgaaggtcc gcaagcacat caatgatctt      540

tatgaagatc tgcgggatgg ccataacctg atctctctgt tggaggtcct ctcaggcatc      600

aaactgcccc gggagaaggg caggatgcgt tttcataggc tgcagaatgt gcagattgcc      660

ctggacttcc taaagcagcg acaggtgaaa ctagtgaata ttcgcaatga tgacatcaca      720

gatggcaacc ccaagttgac cctgggtctg atctggacca ttattttgca tttccagatc      780

tctgacatct acattagtgg agaatcaggg gatatgtcag ccaaggagaa actactcctg      840

tggacccaga aggtgacagc tggttacaca ggaatcaaat gcaccaactt ttcctcctgc      900

tggagtgatg ggaagatgtt caatgcactc attcaccgat accgacccga tctagtagac      960

atggagaggg tgcaaatcca aagtaaccga gagaatctgg aacaggcttt tgaagtggca     1020

gaaagactgg gggtcactcg cctgctggat gcagaagatg tggatgtgcc atctccagat     1080

gaaaagtctg taatcactta tgtgtcttcg atttatgatg ccttccctaa agttcctgag     1140

ggtggagaag ggatcagtgc tacggaagtg gactccaggt ggcaagaata ccaaagccga     1200

gtggactccc tcattccctg gatcaaacag catacaatac tgatgtcaga taaaactttt     1260

ccccaaaacc ctgttgaact aaaggcactt tataaccaat atatacactt caaagaaaca     1320

gaaattctgg ccaaggagag agaaaaagga agaattgagg aattatataa attactagag     1380

gtgtggattg aatttggccg aattaaactg cctcaaggtt atcaccctaa tgatgtggaa     1440

gaagagtggg gaaagctcat catagagatg ctggaacgag agaaatcact tcggccggct     1500

gtggagaggc tggaattgct gctacagatt gcaaacaaaa tccagaatgg tgctttgaac     1560

tgtgaagaaa aactgacact agctaagaat acactgcagg ctgatgctgc tcacctggaa     1620

tcaggacaac cggtacaatg tgagtcagat gtcattatgt acattcagga gtgtgaaggt     1680

ctcatcaggc agctgcaggt ggatctccag atcctgcggg atgagaatta ctaccagcta     1740

gaagagctgg cttttagggt catgcgtctt caggatgagc tggtcacctt gcgtctagag     1800

tgtacaaacc tgtaccggaa gggtcatttc acttcacttg aattggttcc accctctact     1860

ttaaccacca ctcatctgaa agcagaaccc ttaaccaagg caacccattc ttcttctacc     1920

tcctggttcc gaaagcctat gactcgggct gaacttgtgg ccatcagctc ctctgaagat     1980

gaaggcaatc tccgatttgt gtatgaacta ctgtcttggg tagaagagat gcagatgaaa     2040

ctggagcgag cagagtgggg caatgacctg cctagtgtgg agttgcagct agaaacacag     2100

cagcacatcc atacgagtgt agaagagctg ggctcaagtg tcaaggaggc caggttgtat     2160

gagggaaaga tgtcccagaa tttccatacc agctatgctg aaactcttgg aaagctggag     2220

acacagtatt gtaaattgaa ggaaacttct agcttccgga tgaggcacct tcagagcctg     2280

cataaatttg tttccagagc tacagctgag ttgatctggt tgaatgagaa ggaggaggag     2340

gaactagcat atgactggag tgacaacaat tccaatatct cagccaagag aaattacttc     2400

tctgagttga caatggaact ggaggagaaa caggatgtgt ttcgttctct acaagataca     2460

gcagaactac tttcacttga gaaccaccca gccaagcaga cagtggaggc ttacagtgct     2520

gctgtccagt cccagttgca gtggatgaag cagctgtgcc tgtgtgttga gcagcatgtg     2580

aaagagaata ctgcttattt tcagttcttc agtgatgcac gagagctgga gtcattcttg     2640

aggaacctcc aagattccat taaacgaaaa tattcctgtg accacaacac cagcttatcc     2700

cgccttgaag acctgctcca ggactccatg gatgaaaagg agcagcttat acagtccaag     2760

agttccgttg ccagtctcgt tgggagatca aaaaccatcg ttcagctaaa accacgcagt     2820

ccagaccatg tgttaaagaa caccatttct gtcaaggctg tctgtgacta caggcagatc     2880

gagattacta tttgcaaaaa tgatgaatgt gtgctagaag ataattctca gcggaccaaa     2940

tggaaagtga tcagccccac agggaacgag gcaatggtgc cgtcagtctg cttcctcatc     3000

cccccaccca ataaggatgc cattgagatg gccagcaggg tcgaacaatc ttatcagaag     3060

gttatggccc tttggcatca gctgcatgtt aacaccaaaa gccttatctc ttggaactat     3120

ctgcgtaaag accttgacct tgtacagacc tggaacctag aaaagcttcg atcctcagca     3180

ccaggggagt gccatcagat tatgaagaac cttcaggccc actatgaaga ctttctgcag     3240

gatagtcgtg actctgtgct gttctcagtg gctgatcgct tgcgcttgga agaggaggtg     3300

gaagcttgta aagcccgctt ccagcacctg atgaagtcca tggagaatga ggacaaagag     3360

gagactgtgg ccaagatgta catttcagag ttgaagaaca tccggctacg cctggaggag     3420

tatgaacaga gggtggtcaa acgaattcag tctctagcca gctctaggac tgacagagat     3480

gcctggcagg acaatgcatt aaggattgca gagcaagagc acacccagga ggatttacag     3540

caattgaggt cagacttgga tgcagtttct atgaaatgtg acagctttct ccatcagtct     3600

ccatctagtt caagtgtccc aactctgcgc tcagaactga atctgctggt ggagaagatg     3660

gaccatgtct atggtctctc tactgtatat ctgaataagt taaagacagt tgatgttata     3720

gtacgtagca tacaggatgc tgaactcttg gtcaaaggtt atgagattaa gctgagtcaa     3780

gaagaagtag tactggcaga tctctcagct ctggaggccc attggtcgac attacggcac     3840

tggcttagtg atgtgaagga caagaattca gtgttttcag tcctggatga ggaaattgcc     3900

aaggccaagg tagtggcaga gcagatgagt cgtctgacac cagagcgaaa tctggatttg     3960

gagcgctatc aggaaaaagg ctcccagctg caggagcgtt ggcaccgagt cattgcccag     4020

ctcgagattc gccaatctga gctagaaagt atccaggaag ttctgggaga ttaccgagcc     4080

tgccatggaa ctctcatcaa gtggattgag gaaaccactg cccagcagga aatgatgaag     4140

ccaggccagg cagaggatag cagagtgctt tcggagcagc tcagccagca gacggcccta     4200

tttgcagaaa ttgagagaaa tcagacaaaa ctggatcaat gtcaaaaatt ttcccagcag     4260

tactctacta ttgtaaagga ctatgaattg caactgatga catacaaggc ctttgtggaa     4320

tcgcagcaga aatcccctgg caagcgccgt cgcatgcttt cctcttcaga tgccatcact     4380

caagagttca tggacttaag gactcgctac acggcattgg tgactttaac aactcagcac     4440

gtgaaataca tcagtgatgc actccggcgt ctggaggagg aggagaaagt ggtagaagag     4500

gagaaacaag aacatgtgga gaaggttaaa gaacttttgg gctgggtgtc taccctagcg     4560

aggaatacac aaggaaaagc tacctcatcc gagaccaaag aatcaacaga cattgaaaaa     4620

gctattttgg aacagcaggt tctgtcagaa gagctgacaa caaagaaaga acaagtctct     4680

gaagctatta aaacatcaca gatcttcttg gccaagcatg gtcataagct ctcagaaaaa     4740

gagaagaaac aaatatctga gcaattgaat gccctaaaca aggcttacca tgacctttgt     4800

gatggttctg caaatcagct tcagcagctt cagagccagt tggctcacca gacagaacaa     4860

aagaccctgc agaaacaaca aaatacctgt caccagcaac tggaggatct ttgcagttgg     4920

gtaggacagg cagaaagagc actggcaggc caccaaggca gaaccaccca gcaggatctc     4980

tctgctttgc agaagaacca aagtgacttg aaggatttac aggatgacat tcagaatcgt     5040

gccacctcat ttgccactgt tgtcaaggac attgaggggt tcatggaaga gaatcagacc     5100

aagctgagcc cacgtgagtt gacagctctt cgggaaaagc ttcatcaggc taaggagcaa     5160

tatgaggcgc tccaggaaga gacacgtgtg gcccagaagg aactggagga agcagtgacc     5220

tccgccttac agcaggagac tgaaaagagt aaagcagcaa aggaactggc agagaacaag     5280

aagaagatcg atgctctcct ggattgggta acttcagtag gatcatctgg tggacagctg     5340

ctgaccaacc ttccaggaat ggagcagctc tcgggagcta gcttggagaa aggagccttg     5400

gacaccactg atggttacat gggggtgaat caagccccag agaaactgga caagcaatgt     5460

gagatgatga aggcccgtca ccaagaattg ctgtcccagc agcaaaattt cattctggcc     5520

acccagtcag ctcaggcctt cttggatcag catggccaca atctcacacc tgaggagcaa     5580

cagatgctgc aacagaagct gggagagcta aaggaacaat actctacttc cctggcccaa     5640

tcagaggcag aactgaagca ggtgcagaca cttcaggatg agttgcagaa atttctgcag     5700

gatcataaag agtttgaaag ctggttggaa cgatccgaga aagagctgga gaacatgcat     5760

aagggaggca gcagccccga gacccttccc tccctgctaa agcggcaagg aagcttctca     5820

gaggatgtca tttcccacaa aggagacttg agatttgtga ctatctcagg acagaaagtc     5880

ttggacatgg aaaacagttt taaggaaggc aaagaaccat cagaaattgg aaacttagta     5940

aaggacaagt tgaaggatgc aacagaaaga tacactgctc tccactcaaa gtgtacacga     6000

ttaggatctc acctgaatat gctgttaggc cagtatcatc aattccaaaa cagtgctgac     6060

agcctgcagg cctggatgca ggcttgtgag gccaacgtgg agaagctcct ctcagatact     6120

gttgcctctg accctggagt tctccaggag cagcttgcaa caacaaagca gttgcaggag     6180

gaattggctg agcaccaagt acctgtggaa aaactccaaa aagtagctcg tgacataatg     6240

gaaattgaag gggagccagc cccagaccac aggcatgttc aagaaactac agattccata     6300

ctcagccact tccaaagcct ctcctatagc ctggctgagc gatcttctct gctgcagaaa     6360

gcaattgccc aatctcagag tgtccaggaa agcctggaga gcctgttgca gtctattggg     6420

gaagttgaac aaaacctgga agggaagcag gtgtcatcac tctcatcagg agtcatccag     6480

gaagccttag ccacaaatat gaaattgaag caggacattg ctcggcaaaa gagcagcttg     6540

gaggccaccc gtgagatggt gacccgattc atggagacag cagacagtac tacagcagca     6600

gtgctgcagg gcaaactggc agaggtgagc cagcggttcg aacagctctg tctacagcag     6660

caagaaaagg agagctccct aaagaagctt ctaccccagg cagagatgtt tgaacacctc     6720

tctggtaagc tgcagcagtt catggaaaac aaaagtcgga tgctggcctc tggaaatcag     6780

ccagatcaag atattacaca tttcttccaa cagatccagg agctcaattt ggaaatggaa     6840

gaccaacagg agaacctaga tactcttgag cacctggtca ctgaactgag ctcttgtggc     6900

tttgcgctgg acttgtgcca gcatcaggac agggtacaga atctaagaaa agacttcaca     6960

gagctacaga agacagttaa agagagagag aaagatgcat catcttgcca ggaacagttg     7020

gatgaattcc ggaagctggt caggaccttc cagaaatggt tgaaagaaac tgaagggagt     7080

attccaccta cggaaacttc tatgagtgct aaagagttag aaaagcagat tgaacacctg     7140

aagagtctac tagatgactg ggcaagtaag ggaactctgg tggaagaaat caattgcaaa     7200

ggtacttctt tagaaaatct catcatggaa atcacagcac ctgattccca aggcaagaca     7260

ggttccatac tgccctctgt aggaagctct gtaggcagtg taaacggata ccacacctgc     7320

aaagatctga cggagatcca gtgtgacatg tcagatgtaa acttgaagta tgagaaacta     7380

gggggagtac ttcatgaacg ccaggaaagc cttcaggcta tcctcaacag aatggaggag     7440

gttcacaagg aggcaaactc tgtgctgcag tggctggaat caaaagagga agtcctgaaa     7500

tccatggatg ccatgtcatc tccaaccaag acagaaacag tgaaagccca agctgaatct     7560

aacaaggcct tcctggctga gttggaacag aattctccaa aaattcaaaa agtaaaggaa     7620

gccctggctg gattactggt gacatatccc aactcacagg aagcagaaaa ttggaagaaa     7680

attcaggaag aactcaattc ccgatgggaa agggccactg aggttactgt ggctcggcaa     7740

aggcagctag aggaatctgc aagtcatctg gcctgcttcc aggctgcaga atcccagctc     7800

cggccgtggc tgatggagaa agaactgatg atgggagtgc tggggcccct gtctattgac     7860

cccaacatgt tgaatgcaca aaagcaacag gtccagttta tgctaaagga atttgaagca     7920

cgcaggcaac agcatgagca actgaatgag gcagctcagg gcatcctaac aggccctgga     7980

gatgtctctc tgtccaccag ccaagtacag aaagaactcc agagcatcaa tcagaaatgg     8040

gttgagctga ctgacaaact caactcccgt tccagccaaa ttgaccaagc tattgttaag     8100

agcacccagt accaggaact gctccaggac ttatcagaga aggtgagggc agttggacaa     8160

cggctgagtg tccagtcagc tatcagcacc caaccagagg ctgtaaagca gcaattggaa     8220

gagaccagtg aaattcgatc tgacttggag cagttagacc acgaggttaa ggaggctcag     8280

acactgtgcg atgaactctc agtgctcatt ggtgagcagt acctcaagga tgaactgaag     8340

aagcgtttgg agacagttgc cctgcctctc caaggtttag aagaccttgc agccgatcgc     8400

attaacagac tccaggcagc tcttgccagc acccagcagt tccagcaaat gtttgatgag     8460

ttgaggacct ggttggatga taaacaaagc cagcaagcaa aaaactgccc aatttctgca     8520

aaattggagc ggctacagtc tcagctacag gagaatgaag agtttcagaa aagtcttaat     8580

caacacagtg gctcctatga ggtgattgtg gctgaagggg aatctctact tctttctgta     8640

cctcctggag aagagaaaag gactctacaa aaccagttgg ttgagctcaa aaaccattgg     8700

gaagagctta gtaaaaaaac tgcagacaga caatccaggc tcaaggattg tatgcagaaa     8760

gctcagaaat atcagtggca tgtggaagac cttgtgccat ggatagaaga ttgtaaagct     8820

aagatgtctg agttgcgagt cactctggat ccagtgcagc tagagtccag tctcctaaga     8880

tcaaaggcta tgctgaatga ggtggagaag cgccgctccc tgctggaaat attgaatagt     8940

gctgctgaca ttctgatcaa ttcttcagaa gcagatgagg atggaatccg ggatgagaag     9000

gctgggatca accagaacat ggatgctgtt acagaagagc tgcaggccaa aacagggtca     9060

ctcgaagaaa tgactcagag gctcagggag ttccaggaaa gctttaagaa tattgaaaag     9120

aaggttgaag gagccaaaca ccaacttgag atctttgatg ctctgggttc tcaagcctgt     9180

agcaacaaga acctggagaa gctaagagct caacaggaag tgctgcaggc cctagagcct     9240

caggtagact atctgaggaa ctttactcag ggtctggtag aagatgcccc agatggatct     9300

gatgcttctc aacttctcca ccaagctgag gtcgcccagc aagagttcct cgaagttaag     9360

caaagagtga acagtggttg tgtgatgatg gaaaacaagc tggaggggat tggccagttt     9420

cactgccggg tccgagagat gttctctcaa ttggcagacc tggatgatga gctagatggc     9480

atgggtgcta ttggcagaga cactgatagc ctccagtccc aaatcgagga tgtccggcta     9540

ttccttaaca aaattcacgt cctcaaatta gacatagagg cctctgaagc agagtgtcga     9600

catatgctag aagaagaggg gactctggat ttgttaggtc tcaaaaggga gctagaagcc     9660

ctgaacaaac agtgtggcaa actgacagag agggggaaag ctcgtcagga acagctggaa     9720

ctgacactag gccgtgtaga ggacttctac aggaaattga aaggactcaa tgacgcgacc     9780

acagcagcag aggaggcaga ggccctccag tgggtagtgg ggaccgaagt ggaaatcatc     9840

aaccaacaat tagcagattt taaaatgttt cagaaagaac aagtggatcc tcttcagatg     9900

aaattgcagc aggtgaatgg acttggccag ggattaattc agagtgcagg aaaagactgt     9960

gatgtacagg gtttagaaca tgacatggaa gagatcaatg ctcgatggaa tacattgaat    10020

aaaaaggtcg cacaaagaat tgcacagcta caggaagctt tgttgcattg tgggaagttt    10080

caagatgcct tggagccatt gctcagctgg ttggcagata ccgaggagct catagccaat    10140

cagaaacctc catctgctga gtataaagtg gtgaaagcac agatccaaga acagaagttg    10200

ctccagcggc tcctagatga tcgaaaggcc acagtagaca tgcttcaagc agaaggaggc    10260

agaatagccc agtcagcaga gctggctgat agagagaaaa tcactggaca gctggagagt    10320

cttgaaagta gatggactga actactcagt aaggcagcag ccaggcaaaa acagctggaa    10380

gacatcctgg ttctggccaa acagttccat gagacagctg agcctatttc tgacttctta    10440

tctgtcacag agaaaaagct tgctaactca gaacctgttg gcactcagac tgccaaaata    10500

cagcagcaga tcattcggca caaggctctg gaagaagaca tagaaaacca tgcaacagat    10560

gtgcaccagg cagtcaaaat tgggcagtcc ctctcctccc tgacatctcc tgcagaacag    10620

ggtgtgctgt cagaaaagat agactcattg caggcccgat acagtgaaat tcaagaccgc    10680

tgttgtcgga aggcagccct acttgaccaa gctctgtcta atgctaggct gtttggggag    10740

gatgaggtgg aggtgctcaa ctggctggct gaggttgagg acaagctcag ttcagtgttc    10800

gtaaaggatt tcaaacagga tgtcctgcac aggcagcatg ctgaccacct ggctttaaat    10860

gaagaaattg ttaatagaaa gaagaatgta gatcaagcta ttaaaaatgg tcaggctctt    10920

ctaaaacaaa ccacaggtga ggaggtgtta cttatccagg aaaaactaga tggtataaag    10980

actcgttacg cagacatcac agttactagc tccaaggccc tcagaacttt agagcaagcc    11040

cggcagctgg ccaccaagtt ccagtctact tatgaggaac tgaccgggtg gctgagggag    11100

gtggaggagg agctggcaac cagtggagga cagtctccca caggggaaca gataccccag    11160

tttcagcaga gacagaagga attaaagaag gaggtcatgg agcacaggct ggtgttggac    11220

acagtgaatg aggtgagccg tgctctctta gagctggtgc cctggagagc cagagaaggg    11280

ctggataaac ttgtgtccga tgctaacgag cagtacaaac tagtcagtga cactattgga    11340

caaagggtgg atgaaattga tgctgctatt cagagatcac aacagtatga gcaagctgcc    11400

gatgcagaac tagcttgggt tgctgaaaca aaacggaaac tgatggctct gggtccaatt    11460

cgcctggaac aggaccagac cacagctcag cttcaggtac agaaggcttt ctccattgac    11520

attattcgac acaaagattc aatggatgaa ctcttcagtc accgtagtga aatctttggc    11580

acatgtgggg aggagcaaaa aactgtatta caggaaaaga cagagtctct aatacagcaa    11640

tatgaagcca ttagcctact caattcagag cgttatgccc gcctagagcg ggcccaggtc    11700

ttagtaaacc agttttggga aacttatgaa gagctcagcc cctggattga ggaaactcgg    11760

gcactaatag cacagttacc ctctccagcc attgatcatg agcagctcag gcagcaacaa    11820

gaggaaatga ggcaattaag ggaatctatt gctgaacaca aacctcatat tgacaaacta    11880

ctaaagatag gcccacaact aaaggaatta aaccctgagg aaggggaaat ggtggaagaa    11940

aaataccaga aagcagaaaa catgtatgcc caaataaagg aggaggtgcg ccagcgagcc    12000

ctggctctgg atgaagccgt gtcccagtcc acacagatta cagagtttca tgataaaatt    12060

gagcctatgt tggagacact ggagaatctt tcctctcgcc tgcgtatgcc accactgatc    12120

cctgctgaag tagacaagat cagagagtgc atcagtgaca ataagagtgc caccgtggag    12180

ctagaaaaac tgcagccatc ctttgaggcc ttgaagcgcc gtggagagga gcttattgga    12240

cgatctcagg gagcagacaa ggatctggct gcaaaagaaa tccaggataa attggatcaa    12300

atggtattct tctgggagga catcaaagct cgggctgaag aacgagaaat caaatttctt    12360

gatgtccttg aattagcaga gaagttctgg tatgacatgg cagctctcct gaccaccatc    12420

aaagacaccc aggatattgt ccatgacttg gaaagcccag gcattgatcc ttccatcatc    12480

aaacaacagg ttgaagctgc tgagactatt aaggaagaga cagatggtct gcatgaagag    12540

ctggagttta ttcggatcct tggagcagat ttgatttttg cctgtggaga aactgagaag    12600

cctgaagtga ggaagagcat tgatgagatg aataatgctt gggagaactt aaacaaaaca    12660

tggaaagaga ggctagaaaa acttgaggat gctatgcaag ctgctgtgca gtatcaggac    12720

actcttcagg ctatgtttga ctggctagat aacactgtga ttaaactctg caccatgccc    12780

cctgttggca ctgacctcaa tactgttaaa gatcagttaa atgaaatgaa ggagttcaaa    12840

gtagaagttt accaacagca aattgagatg gagaagctta atcaccaggg tgaactgatg    12900

ttaaagaaag ctactgatga gacggacaga gacattatac gagaaccact gacagaactc    12960

aaacacctct gggagaacct gggtgagaaa attgcccacc gacagcacaa actagaaggg    13020

gctctgttgg cccttggtca gttccagcat gccttagagg aactaatgag ttggctgact    13080

cataccgaag agttgttaga tgctcagaga ccaataagtg gagacccaaa agtcattgaa    13140

gttgagctcg caaagcacca tgtcctaaaa aatgatgttt tggctcatca agccacagtg    13200

gaaacagtca acaaagctgg caatgagctt cttgaatcca gtgctggaga tgatgccagc    13260

agcttaagga gccgtttgga agccatgaac caatgctggg agtcagtgtt acagaaaaca    13320

gaggagaggg agcagcagct tcagtcaact ctgcagcagg cccagggctt ccacagtgaa    13380

attgaagatt tcctcttgga acttactaga atggagagcc agctttctgc atctaagccc    13440

acaggaggac ttcctgaaac tgctagggaa cagcttgata cacatatgga actctattcc    13500

cagctgaaag ccaaggaaga gacttataat caactacttg acaagggcag actcatgctt    13560

ctaagccgtg acgactctgg gtctggctcc aagacagaac agagtgtagc acttttggag    13620

cagaagtggc atgtggtcag cagtaagatg gaagaaagaa agtcaaagct ggaagaggcc    13680

ctcaacttgg caacagaatt ccagaattcc ctacaagaat ttatcaactg gctcactcta    13740

gcagagcaga gtttaaacat cgcttctcca ccaagcctga ttctaaatac tgtcctttcc    13800

cagatagaag agcacaaggt ttttgctaat gaagtaaatg ctcatcgaga ccagatcatt    13860

gagctggatc aaactgggaa tcaattaaag ttccttagcc aaaagcagga tgttgttctg    13920

atcaagaatt tgttggtgag cgtgcagtct cgatgggaga aggttgtcca gcgatctatt    13980

gaaagagggc gatcactaga tgatgccagg aagcgggcaa aacaattcca tgaagcttgg    14040

aaaaaactga ttgactggct agaagatgca gagagtcacc tggactcaga actagagata    14100

tccaatgacc cagacaaaat taaacttcag ctttctaagc ataaggagtt tcagaagact    14160

cttggtggca agcagcctgt gtatgatacc acaattagaa ctggcagagc actgaaagaa    14220

aagactttgc ttcccgaaga tagtcagaaa cttgacaatt tcctaggaga agtcagagac    14280

aaatgggata ctgtttgtgg caagtctgtg gagcggcagc acaagttgga ggaagccctg    14340

ctcttttcgg gtcagttcat ggatgctttg caggcattgg ttgactggtt atacaaggtg    14400

gagccacagc tggctgagga ccagcccgtg cacggggacc ttgacctcgt catgaacctc    14460

atggatgcac acaaggtttt ccagaaggaa ctgggaaagc gaacaggaac cgttcaggtc    14520

ctgaagcggt caggccgaga gctgattgag aatagtcgag atgacaccac ttgggtaaaa    14580

ggacagctcc aggaactgag cactcgctgg gacactgtct gtaaactctc tgtttccaaa    14640

caaagccggc ttgagcaggc cttaaaacaa gcggaagtgt ttcgagacac agtccacatg    14700

ctgttggagt ggctttctga agcagagcaa acgcttcgct ttcggggagc acttcctgat    14760

gacacagagg ccctgcagtc tctcattgac acccataagg aattcatgaa gaaagtagaa    14820

gaaaagcgag tggacgttaa ctcagcagta gccatgggag aagtcatcct ggctgtctgc    14880

caccccgatt gcatcacaac catcaaacac tggatcacca tcatccgagc tcgcttcgag    14940

gaggtcctga catgggctaa gcagcaccag cagcgtcttg aaacggcctt gtcagaactg    15000

gtggctaatg ctgagctcct ggaagaactt ctggcatgga tccagtgggc tgagaccacc    15060

ctcattcagc gggatcagga gccaatcccg cagaacattg accgagttaa agcccttatc    15120

gctgagcatc agacatttat ggaggagatg actcgcaaac agcctgacgt ggaccgggtc    15180

accaagacat acaaaaggaa aaacatagag cctactcacg cgcctttcat agagaaatcc    15240

cgcagcggag gcaggaaatc cctaagtcag ccaacccctc ctcccatgcc aatcctttca    15300

cagtctgaag caaaaaaccc acggatcaac cagctttctg cccgctggca gcaggtgtgg    15360

ctgttagcac tggagcggca aaggaaactg aatgatgcct tggatcggct ggaggagttg    15420

aaagaatttg ccaactttga ctttgatgtc tggaggaaaa agtatatgcg ttggatgaat    15480

cacaaaaagt ctcgagtgat ggatttcttc cggcgcattg ataaggacca ggatgggaag    15540

ataacacgtc aggagtttat cgatggcatt ttagcatcca agttccccac caccaagtta    15600

gagatgactg ctgtggctga cattttcgac cgagatgggg atggttacat tgattattat    15660

gaatttgtgg ctgctcttca tcccaacaag gatgcgtatc gaccaacaac cgatgcagat    15720

aaaatcgaag atgaggttac aagacaagtg gctcagtgca aatgtgcaaa aaggtttcag    15780

gtggagcaga tcggagagaa taaataccgg tttggggatt ctcagcagtt gcggctggtc    15840

cgtattctgc gcagcaccgt gatggttcgc gttggtggag gatggatggc cttggatgaa    15900

tttttagtga aaaatgatcc ctgccgagca cgaggtagaa ctaacattga acttagagag    15960

aaattcatcc taccagaggg agcatcccag ggaatgaccc ccttccgctc acggggtcga    16020

aggtccaaac catcttcccg ggcagcttcc cctactcgtt ccagctccag tgctagtcag    16080

agtaaccaca gctgtacatc catgccatct tctccagcca ccccagccag tggaaccaag    16140

gttatcccat catcaggtag caagttgaaa cgaccaacac caacttttca ttctagtcgg    16200

acatcccttg ctggtgatac cagcaatagt tcttccccgg cctccacagg tgccaaaact    16260

aatcgggcag accctaaaaa gtctgccagt cgccctggga gtcgggctgg gagtcgagcc    16320

gggagtcgag ccagcagccg gcgaggaagt gacgcttctg actttgacct cttagagacg    16380

cagtctgctt gttccgacac ttcagaaagc agcgctgcag ggggccaagg caactccagg    16440

agagggctaa acaaaccttc caaaatccca accatgtcta agaagaccac cactgcctcc    16500

cccaggactc caggtcccaa gcgataacac tgtctaagca cccccaagcc actatccact    16560

ttgaatcctg ctccatacat tgggtgtata tttattctga acgggagaag ttatattgtt    16620

aaaagtgtaa aagaataatt gtgttatgaa gctgccttat tttttttctt tttgtaagtt    16680

actattttca tgtgaatatt tatgtagata aaatttgcct cctggtaacc ctgtaatgga    16740

tggggcccag aaatgaaata tttgagaaaa acaagtgaaa aggtcaagat acaaatgtgt    16800

attaaaaaaa aaaaagccta ttaatagggt ttctgcgcgg tgcagggttg taaacctgct    16860

ttatctttta ggattattcc taaatgcatc ttctttataa acttgacttg ctatctcagc    16920

aagataaatt atattaaaaa aataagaatc ctgcagtgtt taaggaactc tttttttgta    16980

aatcacggac acctcaatta gcaagaactg aggggagggc tttttccatt gtttaatgtt    17040

ttgtgatttt tagctaaaga gagggaacct catctaagta acatttgcac atgatacagc    17100

aaaaggagtt cattgcaata ctgtctttgg atattgtttc agtactgggt gtttaaagga    17160

caaatagctg ctagaattca ggggtaaatg taagtgttca gaaaacgtca gaacatttgg    17220

ggttttaaac tgatttgttg ctccctatcc agcctagaca ccagtaactc ttgtgttcac    17280

caggacccag acccttggca agggataggc tcgttggtga cattgtgaat ttcagatttg    17340

ttttatccac tttttttgct atttatttaa atggtcgatc aacttcccac aaactgagga    17400

atgaattcca cgagcctgtt ctgaaaatgt ggacgtaaga caaacacgtg ctcgtccttt    17460

aatggagttc accagcacac ttgttaacca gtcctgtttg ctttcgtctt tttttgtgcg    17520

taataaagtc aactgaccaa gtgaccatga aaaggggctg tctggggctc ctgtttttta    17580

gctgctgttc ttcagctccg accatgttgc tgtgtgatta tctcaattgg ttttaattga    17640

ggcagaaact gaagctctac caatgaactg tttagaaaca agacacactt ttgtattaaa    17700

attgcttgca gtaacaaata ttttgtattt cctgattttc ttttcaacta ttaccttatc    17760

tataaatgtt accctggggt ataatcatgt tgtaggtact taaatgcatt ccgcaaatca    17820

aaatatcttg atggataaat tatagagctt aatagatctt gttttatttc aaaaaaaaaa    17880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                 17928


<210> 436
<211> 5430
<212> PRT
<213> Homo sapiens

<400> 436
Met Ser Ser Ser Asp Glu Glu Thr Leu Ser Glu Arg Ser Cys Arg Ser 
1               5                   10                  15      


Glu Arg Ser Cys Arg Ser Glu Arg Ser Tyr Arg Ser Glu Arg Ser Gly 
            20                  25                  30          


Ser Leu Ser Pro Cys Pro Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro 
        35                  40                  45              


Leu His Glu Gln Lys Lys Arg Lys Ser Gln Asp Ser Val Leu Asp Pro 
    50                  55                  60                  


Ala Glu Arg Ala Val Val Arg Val Ala Asp Glu Arg Asp Arg Val Gln 
65                  70                  75                  80  


Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His Leu Met Lys Val Arg 
                85                  90                  95      


Lys His Ile Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu 
            100                 105                 110         


Ile Ser Leu Leu Glu Val Leu Ser Gly Ile Lys Leu Pro Arg Glu Lys 
        115                 120                 125             


Gly Arg Met Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp 
    130                 135                 140                 


Phe Leu Lys Gln Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp 
145                 150                 155                 160 


Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile 
                165                 170                 175     


Ile Leu His Phe Gln Ile Ser Asp Ile Tyr Ile Ser Gly Glu Ser Gly 
            180                 185                 190         


Asp Met Ser Ala Lys Glu Lys Leu Leu Leu Trp Thr Gln Lys Val Thr 
        195                 200                 205             


Ala Gly Tyr Thr Gly Ile Lys Cys Thr Asn Phe Ser Ser Cys Trp Ser 
    210                 215                 220                 


Asp Gly Lys Met Phe Asn Ala Leu Ile His Arg Tyr Arg Pro Asp Leu 
225                 230                 235                 240 


Val Asp Met Glu Arg Val Gln Ile Gln Ser Asn Arg Glu Asn Leu Glu 
                245                 250                 255     


Gln Ala Phe Glu Val Ala Glu Arg Leu Gly Val Thr Arg Leu Leu Asp 
            260                 265                 270         


Ala Glu Asp Val Asp Val Pro Ser Pro Asp Glu Lys Ser Val Ile Thr 
        275                 280                 285             


Tyr Val Ser Ser Ile Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly 
    290                 295                 300                 


Glu Gly Ile Ser Ala Thr Glu Val Asp Ser Arg Trp Gln Glu Tyr Gln 
305                 310                 315                 320 


Ser Arg Val Asp Ser Leu Ile Pro Trp Ile Lys Gln His Thr Ile Leu 
                325                 330                 335     


Met Ser Asp Lys Thr Phe Pro Gln Asn Pro Val Glu Leu Lys Ala Leu 
            340                 345                 350         


Tyr Asn Gln Tyr Ile His Phe Lys Glu Thr Glu Ile Leu Ala Lys Glu 
        355                 360                 365             


Arg Glu Lys Gly Arg Ile Glu Glu Leu Tyr Lys Leu Leu Glu Val Trp 
    370                 375                 380                 


Ile Glu Phe Gly Arg Ile Lys Leu Pro Gln Gly Tyr His Pro Asn Asp 
385                 390                 395                 400 


Val Glu Glu Glu Trp Gly Lys Leu Ile Ile Glu Met Leu Glu Arg Glu 
                405                 410                 415     


Lys Ser Leu Arg Pro Ala Val Glu Arg Leu Glu Leu Leu Leu Gln Ile 
            420                 425                 430         


Ala Asn Lys Ile Gln Asn Gly Ala Leu Asn Cys Glu Glu Lys Leu Thr 
        435                 440                 445             


Leu Ala Lys Asn Thr Leu Gln Ala Asp Ala Ala His Leu Glu Ser Gly 
    450                 455                 460                 


Gln Pro Val Gln Cys Glu Ser Asp Val Ile Met Tyr Ile Gln Glu Cys 
465                 470                 475                 480 


Glu Gly Leu Ile Arg Gln Leu Gln Val Asp Leu Gln Ile Leu Arg Asp 
                485                 490                 495     


Glu Asn Tyr Tyr Gln Leu Glu Glu Leu Ala Phe Arg Val Met Arg Leu 
            500                 505                 510         


Gln Asp Glu Leu Val Thr Leu Arg Leu Glu Cys Thr Asn Leu Tyr Arg 
        515                 520                 525             


Lys Gly His Phe Thr Ser Leu Glu Leu Val Pro Pro Ser Thr Leu Thr 
    530                 535                 540                 


Thr Thr His Leu Lys Ala Glu Pro Leu Thr Lys Ala Thr His Ser Ser 
545                 550                 555                 560 


Ser Thr Ser Trp Phe Arg Lys Pro Met Thr Arg Ala Glu Leu Val Ala 
                565                 570                 575     


Ile Ser Ser Ser Glu Asp Glu Gly Asn Leu Arg Phe Val Tyr Glu Leu 
            580                 585                 590         


Leu Ser Trp Val Glu Glu Met Gln Met Lys Leu Glu Arg Ala Glu Trp 
        595                 600                 605             


Gly Asn Asp Leu Pro Ser Val Glu Leu Gln Leu Glu Thr Gln Gln His 
    610                 615                 620                 


Ile His Thr Ser Val Glu Glu Leu Gly Ser Ser Val Lys Glu Ala Arg 
625                 630                 635                 640 


Leu Tyr Glu Gly Lys Met Ser Gln Asn Phe His Thr Ser Tyr Ala Glu 
                645                 650                 655     


Thr Leu Gly Lys Leu Glu Thr Gln Tyr Cys Lys Leu Lys Glu Thr Ser 
            660                 665                 670         


Ser Phe Arg Met Arg His Leu Gln Ser Leu His Lys Phe Val Ser Arg 
        675                 680                 685             


Ala Thr Ala Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Leu 
    690                 695                 700                 


Ala Tyr Asp Trp Ser Asp Asn Asn Ser Asn Ile Ser Ala Lys Arg Asn 
705                 710                 715                 720 


Tyr Phe Ser Glu Leu Thr Met Glu Leu Glu Glu Lys Gln Asp Val Phe 
                725                 730                 735     


Arg Ser Leu Gln Asp Thr Ala Glu Leu Leu Ser Leu Glu Asn His Pro 
            740                 745                 750         


Ala Lys Gln Thr Val Glu Ala Tyr Ser Ala Ala Val Gln Ser Gln Leu 
        755                 760                 765             


Gln Trp Met Lys Gln Leu Cys Leu Cys Val Glu Gln His Val Lys Glu 
    770                 775                 780                 


Asn Thr Ala Tyr Phe Gln Phe Phe Ser Asp Ala Arg Glu Leu Glu Ser 
785                 790                 795                 800 


Phe Leu Arg Asn Leu Gln Asp Ser Ile Lys Arg Lys Tyr Ser Cys Asp 
                805                 810                 815     


His Asn Thr Ser Leu Ser Arg Leu Glu Asp Leu Leu Gln Asp Ser Met 
            820                 825                 830         


Asp Glu Lys Glu Gln Leu Ile Gln Ser Lys Ser Ser Val Ala Ser Leu 
        835                 840                 845             


Val Gly Arg Ser Lys Thr Ile Val Gln Leu Lys Pro Arg Ser Pro Asp 
    850                 855                 860                 


His Val Leu Lys Asn Thr Ile Ser Val Lys Ala Val Cys Asp Tyr Arg 
865                 870                 875                 880 


Gln Ile Glu Ile Thr Ile Cys Lys Asn Asp Glu Cys Val Leu Glu Asp 
                885                 890                 895     


Asn Ser Gln Arg Thr Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu 
            900                 905                 910         


Ala Met Val Pro Ser Val Cys Phe Leu Ile Pro Pro Pro Asn Lys Asp 
        915                 920                 925             


Ala Ile Glu Met Ala Ser Arg Val Glu Gln Ser Tyr Gln Lys Val Met 
    930                 935                 940                 


Ala Leu Trp His Gln Leu His Val Asn Thr Lys Ser Leu Ile Ser Trp 
945                 950                 955                 960 


Asn Tyr Leu Arg Lys Asp Leu Asp Leu Val Gln Thr Trp Asn Leu Glu 
                965                 970                 975     


Lys Leu Arg Ser Ser Ala Pro Gly Glu Cys His Gln Ile Met Lys Asn 
            980                 985                 990         


Leu Gln Ala His Tyr Glu Asp Phe  Leu Gln Asp Ser Arg  Asp Ser Val 
        995                 1000                 1005             


Leu Phe  Ser Val Ala Asp Arg  Leu Arg Leu Glu Glu  Glu Val Glu 
    1010                 1015                 1020             


Ala Cys  Lys Ala Arg Phe Gln  His Leu Met Lys Ser  Met Glu Asn 
    1025                 1030                 1035             


Glu Asp  Lys Glu Glu Thr Val  Ala Lys Met Tyr Ile  Ser Glu Leu 
    1040                 1045                 1050             


Lys Asn  Ile Arg Leu Arg Leu  Glu Glu Tyr Glu Gln  Arg Val Val 
    1055                 1060                 1065             


Lys Arg  Ile Gln Ser Leu Ala  Ser Ser Arg Thr Asp  Arg Asp Ala 
    1070                 1075                 1080             


Trp Gln  Asp Asn Ala Leu Arg  Ile Ala Glu Gln Glu  His Thr Gln 
    1085                 1090                 1095             


Glu Asp  Leu Gln Gln Leu Arg  Ser Asp Leu Asp Ala  Val Ser Met 
    1100                 1105                 1110             


Lys Cys  Asp Ser Phe Leu His  Gln Ser Pro Ser Ser  Ser Ser Val 
    1115                 1120                 1125             


Pro Thr  Leu Arg Ser Glu Leu  Asn Leu Leu Val Glu  Lys Met Asp 
    1130                 1135                 1140             


His Val  Tyr Gly Leu Ser Thr  Val Tyr Leu Asn Lys  Leu Lys Thr 
    1145                 1150                 1155             


Val Asp  Val Ile Val Arg Ser  Ile Gln Asp Ala Glu  Leu Leu Val 
    1160                 1165                 1170             


Lys Gly  Tyr Glu Ile Lys Leu  Ser Gln Glu Glu Val  Val Leu Ala 
    1175                 1180                 1185             


Asp Leu  Ser Ala Leu Glu Ala  His Trp Ser Thr Leu  Arg His Trp 
    1190                 1195                 1200             


Leu Ser  Asp Val Lys Asp Lys  Asn Ser Val Phe Ser  Val Leu Asp 
    1205                 1210                 1215             


Glu Glu  Ile Ala Lys Ala Lys  Val Val Ala Glu Gln  Met Ser Arg 
    1220                 1225                 1230             


Leu Thr  Pro Glu Arg Asn Leu  Asp Leu Glu Arg Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Gly Ser  Gln Leu Gln Glu Arg  Trp His Arg Val Ile  Ala Gln Leu 
    1250                 1255                 1260             


Glu Ile  Arg Gln Ser Glu Leu  Glu Ser Ile Gln Glu  Val Leu Gly 
    1265                 1270                 1275             


Asp Tyr  Arg Ala Cys His Gly  Thr Leu Ile Lys Trp  Ile Glu Glu 
    1280                 1285                 1290             


Thr Thr  Ala Gln Gln Glu Met  Met Lys Pro Gly Gln  Ala Glu Asp 
    1295                 1300                 1305             


Ser Arg  Val Leu Ser Glu Gln  Leu Ser Gln Gln Thr  Ala Leu Phe 
    1310                 1315                 1320             


Ala Glu  Ile Glu Arg Asn Gln  Thr Lys Leu Asp Gln  Cys Gln Lys 
    1325                 1330                 1335             


Phe Ser  Gln Gln Tyr Ser Thr  Ile Val Lys Asp Tyr  Glu Leu Gln 
    1340                 1345                 1350             


Leu Met  Thr Tyr Lys Ala Phe  Val Glu Ser Gln Gln  Lys Ser Pro 
    1355                 1360                 1365             


Gly Lys  Arg Arg Arg Met Leu  Ser Ser Ser Asp Ala  Ile Thr Gln 
    1370                 1375                 1380             


Glu Phe  Met Asp Leu Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu 
    1385                 1390                 1395             


Thr Thr  Gln His Val Lys Tyr  Ile Ser Asp Ala Leu  Arg Arg Leu 
    1400                 1405                 1410             


Glu Glu  Glu Glu Lys Val Val  Glu Glu Glu Lys Gln  Glu His Val 
    1415                 1420                 1425             


Glu Lys  Val Lys Glu Leu Leu  Gly Trp Val Ser Thr  Leu Ala Arg 
    1430                 1435                 1440             


Asn Thr  Gln Gly Lys Ala Thr  Ser Ser Glu Thr Lys  Glu Ser Thr 
    1445                 1450                 1455             


Asp Ile  Glu Lys Ala Ile Leu  Glu Gln Gln Val Leu  Ser Glu Glu 
    1460                 1465                 1470             


Leu Thr  Thr Lys Lys Glu Gln  Val Ser Glu Ala Ile  Lys Thr Ser 
    1475                 1480                 1485             


Gln Ile  Phe Leu Ala Lys His  Gly His Lys Leu Ser  Glu Lys Glu 
    1490                 1495                 1500             


Lys Lys  Gln Ile Ser Glu Gln  Leu Asn Ala Leu Asn  Lys Ala Tyr 
    1505                 1510                 1515             


His Asp  Leu Cys Asp Gly Ser  Ala Asn Gln Leu Gln  Gln Leu Gln 
    1520                 1525                 1530             


Ser Gln  Leu Ala His Gln Thr  Glu Gln Lys Thr Leu  Gln Lys Gln 
    1535                 1540                 1545             


Gln Asn  Thr Cys His Gln Gln  Leu Glu Asp Leu Cys  Ser Trp Val 
    1550                 1555                 1560             


Gly Gln  Ala Glu Arg Ala Leu  Ala Gly His Gln Gly  Arg Thr Thr 
    1565                 1570                 1575             


Gln Gln  Asp Leu Ser Ala Leu  Gln Lys Asn Gln Ser  Asp Leu Lys 
    1580                 1585                 1590             


Asp Leu  Gln Asp Asp Ile Gln  Asn Arg Ala Thr Ser  Phe Ala Thr 
    1595                 1600                 1605             


Val Val  Lys Asp Ile Glu Gly  Phe Met Glu Glu Asn  Gln Thr Lys 
    1610                 1615                 1620             


Leu Ser  Pro Arg Glu Leu Thr  Ala Leu Arg Glu Lys  Leu His Gln 
    1625                 1630                 1635             


Ala Lys  Glu Gln Tyr Glu Ala  Leu Gln Glu Glu Thr  Arg Val Ala 
    1640                 1645                 1650             


Gln Lys  Glu Leu Glu Glu Ala  Val Thr Ser Ala Leu  Gln Gln Glu 
    1655                 1660                 1665             


Thr Glu  Lys Ser Lys Ala Ala  Lys Glu Leu Ala Glu  Asn Lys Lys 
    1670                 1675                 1680             


Lys Ile  Asp Ala Leu Leu Asp  Trp Val Thr Ser Val  Gly Ser Ser 
    1685                 1690                 1695             


Gly Gly  Gln Leu Leu Thr Asn  Leu Pro Gly Met Glu  Gln Leu Ser 
    1700                 1705                 1710             


Gly Ala  Ser Leu Glu Lys Gly  Ala Leu Asp Thr Thr  Asp Gly Tyr 
    1715                 1720                 1725             


Met Gly  Val Asn Gln Ala Pro  Glu Lys Leu Asp Lys  Gln Cys Glu 
    1730                 1735                 1740             


Met Met  Lys Ala Arg His Gln  Glu Leu Leu Ser Gln  Gln Gln Asn 
    1745                 1750                 1755             


Phe Ile  Leu Ala Thr Gln Ser  Ala Gln Ala Phe Leu  Asp Gln His 
    1760                 1765                 1770             


Gly His  Asn Leu Thr Pro Glu  Glu Gln Gln Met Leu  Gln Gln Lys 
    1775                 1780                 1785             


Leu Gly  Glu Leu Lys Glu Gln  Tyr Ser Thr Ser Leu  Ala Gln Ser 
    1790                 1795                 1800             


Glu Ala  Glu Leu Lys Gln Val  Gln Thr Leu Gln Asp  Glu Leu Gln 
    1805                 1810                 1815             


Lys Phe  Leu Gln Asp His Lys  Glu Phe Glu Ser Trp  Leu Glu Arg 
    1820                 1825                 1830             


Ser Glu  Lys Glu Leu Glu Asn  Met His Lys Gly Gly  Ser Ser Pro 
    1835                 1840                 1845             


Glu Thr  Leu Pro Ser Leu Leu  Lys Arg Gln Gly Ser  Phe Ser Glu 
    1850                 1855                 1860             


Asp Val  Ile Ser His Lys Gly  Asp Leu Arg Phe Val  Thr Ile Ser 
    1865                 1870                 1875             


Gly Gln  Lys Val Leu Asp Met  Glu Asn Ser Phe Lys  Glu Gly Lys 
    1880                 1885                 1890             


Glu Pro  Ser Glu Ile Gly Asn  Leu Val Lys Asp Lys  Leu Lys Asp 
    1895                 1900                 1905             


Ala Thr  Glu Arg Tyr Thr Ala  Leu His Ser Lys Cys  Thr Arg Leu 
    1910                 1915                 1920             


Gly Ser  His Leu Asn Met Leu  Leu Gly Gln Tyr His  Gln Phe Gln 
    1925                 1930                 1935             


Asn Ser  Ala Asp Ser Leu Gln  Ala Trp Met Gln Ala  Cys Glu Ala 
    1940                 1945                 1950             


Asn Val  Glu Lys Leu Leu Ser  Asp Thr Val Ala Ser  Asp Pro Gly 
    1955                 1960                 1965             


Val Leu  Gln Glu Gln Leu Ala  Thr Thr Lys Gln Leu  Gln Glu Glu 
    1970                 1975                 1980             


Leu Ala  Glu His Gln Val Pro  Val Glu Lys Leu Gln  Lys Val Ala 
    1985                 1990                 1995             


Arg Asp  Ile Met Glu Ile Glu  Gly Glu Pro Ala Pro  Asp His Arg 
    2000                 2005                 2010             


His Val  Gln Glu Thr Thr Asp  Ser Ile Leu Ser His  Phe Gln Ser 
    2015                 2020                 2025             


Leu Ser  Tyr Ser Leu Ala Glu  Arg Ser Ser Leu Leu  Gln Lys Ala 
    2030                 2035                 2040             


Ile Ala  Gln Ser Gln Ser Val  Gln Glu Ser Leu Glu  Ser Leu Leu 
    2045                 2050                 2055             


Gln Ser  Ile Gly Glu Val Glu  Gln Asn Leu Glu Gly  Lys Gln Val 
    2060                 2065                 2070             


Ser Ser  Leu Ser Ser Gly Val  Ile Gln Glu Ala Leu  Ala Thr Asn 
    2075                 2080                 2085             


Met Lys  Leu Lys Gln Asp Ile  Ala Arg Gln Lys Ser  Ser Leu Glu 
    2090                 2095                 2100             


Ala Thr  Arg Glu Met Val Thr  Arg Phe Met Glu Thr  Ala Asp Ser 
    2105                 2110                 2115             


Thr Thr  Ala Ala Val Leu Gln  Gly Lys Leu Ala Glu  Val Ser Gln 
    2120                 2125                 2130             


Arg Phe  Glu Gln Leu Cys Leu  Gln Gln Gln Glu Lys  Glu Ser Ser 
    2135                 2140                 2145             


Leu Lys  Lys Leu Leu Pro Gln  Ala Glu Met Phe Glu  His Leu Ser 
    2150                 2155                 2160             


Gly Lys  Leu Gln Gln Phe Met  Glu Asn Lys Ser Arg  Met Leu Ala 
    2165                 2170                 2175             


Ser Gly  Asn Gln Pro Asp Gln  Asp Ile Thr His Phe  Phe Gln Gln 
    2180                 2185                 2190             


Ile Gln  Glu Leu Asn Leu Glu  Met Glu Asp Gln Gln  Glu Asn Leu 
    2195                 2200                 2205             


Asp Thr  Leu Glu His Leu Val  Thr Glu Leu Ser Ser  Cys Gly Phe 
    2210                 2215                 2220             


Ala Leu  Asp Leu Cys Gln His  Gln Asp Arg Val Gln  Asn Leu Arg 
    2225                 2230                 2235             


Lys Asp  Phe Thr Glu Leu Gln  Lys Thr Val Lys Glu  Arg Glu Lys 
    2240                 2245                 2250             


Asp Ala  Ser Ser Cys Gln Glu  Gln Leu Asp Glu Phe  Arg Lys Leu 
    2255                 2260                 2265             


Val Arg  Thr Phe Gln Lys Trp  Leu Lys Glu Thr Glu  Gly Ser Ile 
    2270                 2275                 2280             


Pro Pro  Thr Glu Thr Ser Met  Ser Ala Lys Glu Leu  Glu Lys Gln 
    2285                 2290                 2295             


Ile Glu  His Leu Lys Ser Leu  Leu Asp Asp Trp Ala  Ser Lys Gly 
    2300                 2305                 2310             


Thr Leu  Val Glu Glu Ile Asn  Cys Lys Gly Thr Ser  Leu Glu Asn 
    2315                 2320                 2325             


Leu Ile  Met Glu Ile Thr Ala  Pro Asp Ser Gln Gly  Lys Thr Gly 
    2330                 2335                 2340             


Ser Ile  Leu Pro Ser Val Gly  Ser Ser Val Gly Ser  Val Asn Gly 
    2345                 2350                 2355             


Tyr His  Thr Cys Lys Asp Leu  Thr Glu Ile Gln Cys  Asp Met Ser 
    2360                 2365                 2370             


Asp Val  Asn Leu Lys Tyr Glu  Lys Leu Gly Gly Val  Leu His Glu 
    2375                 2380                 2385             


Arg Gln  Glu Ser Leu Gln Ala  Ile Leu Asn Arg Met  Glu Glu Val 
    2390                 2395                 2400             


His Lys  Glu Ala Asn Ser Val  Leu Gln Trp Leu Glu  Ser Lys Glu 
    2405                 2410                 2415             


Glu Val  Leu Lys Ser Met Asp  Ala Met Ser Ser Pro  Thr Lys Thr 
    2420                 2425                 2430             


Glu Thr  Val Lys Ala Gln Ala  Glu Ser Asn Lys Ala  Phe Leu Ala 
    2435                 2440                 2445             


Glu Leu  Glu Gln Asn Ser Pro  Lys Ile Gln Lys Val  Lys Glu Ala 
    2450                 2455                 2460             


Leu Ala  Gly Leu Leu Val Thr  Tyr Pro Asn Ser Gln  Glu Ala Glu 
    2465                 2470                 2475             


Asn Trp  Lys Lys Ile Gln Glu  Glu Leu Asn Ser Arg  Trp Glu Arg 
    2480                 2485                 2490             


Ala Thr  Glu Val Thr Val Ala  Arg Gln Arg Gln Leu  Glu Glu Ser 
    2495                 2500                 2505             


Ala Ser  His Leu Ala Cys Phe  Gln Ala Ala Glu Ser  Gln Leu Arg 
    2510                 2515                 2520             


Pro Trp  Leu Met Glu Lys Glu  Leu Met Met Gly Val  Leu Gly Pro 
    2525                 2530                 2535             


Leu Ser  Ile Asp Pro Asn Met  Leu Asn Ala Gln Lys  Gln Gln Val 
    2540                 2545                 2550             


Gln Phe  Met Leu Lys Glu Phe  Glu Ala Arg Arg Gln  Gln His Glu 
    2555                 2560                 2565             


Gln Leu  Asn Glu Ala Ala Gln  Gly Ile Leu Thr Gly  Pro Gly Asp 
    2570                 2575                 2580             


Val Ser  Leu Ser Thr Ser Gln  Val Gln Lys Glu Leu  Gln Ser Ile 
    2585                 2590                 2595             


Asn Gln  Lys Trp Val Glu Leu  Thr Asp Lys Leu Asn  Ser Arg Ser 
    2600                 2605                 2610             


Ser Gln  Ile Asp Gln Ala Ile  Val Lys Ser Thr Gln  Tyr Gln Glu 
    2615                 2620                 2625             


Leu Leu  Gln Asp Leu Ser Glu  Lys Val Arg Ala Val  Gly Gln Arg 
    2630                 2635                 2640             


Leu Ser  Val Gln Ser Ala Ile  Ser Thr Gln Pro Glu  Ala Val Lys 
    2645                 2650                 2655             


Gln Gln  Leu Glu Glu Thr Ser  Glu Ile Arg Ser Asp  Leu Glu Gln 
    2660                 2665                 2670             


Leu Asp  His Glu Val Lys Glu  Ala Gln Thr Leu Cys  Asp Glu Leu 
    2675                 2680                 2685             


Ser Val  Leu Ile Gly Glu Gln  Tyr Leu Lys Asp Glu  Leu Lys Lys 
    2690                 2695                 2700             


Arg Leu  Glu Thr Val Ala Leu  Pro Leu Gln Gly Leu  Glu Asp Leu 
    2705                 2710                 2715             


Ala Ala  Asp Arg Ile Asn Arg  Leu Gln Ala Ala Leu  Ala Ser Thr 
    2720                 2725                 2730             


Gln Gln  Phe Gln Gln Met Phe  Asp Glu Leu Arg Thr  Trp Leu Asp 
    2735                 2740                 2745             


Asp Lys  Gln Ser Gln Gln Ala  Lys Asn Cys Pro Ile  Ser Ala Lys 
    2750                 2755                 2760             


Leu Glu  Arg Leu Gln Ser Gln  Leu Gln Glu Asn Glu  Glu Phe Gln 
    2765                 2770                 2775             


Lys Ser  Leu Asn Gln His Ser  Gly Ser Tyr Glu Val  Ile Val Ala 
    2780                 2785                 2790             


Glu Gly  Glu Ser Leu Leu Leu  Ser Val Pro Pro Gly  Glu Glu Lys 
    2795                 2800                 2805             


Arg Thr  Leu Gln Asn Gln Leu  Val Glu Leu Lys Asn  His Trp Glu 
    2810                 2815                 2820             


Glu Leu  Ser Lys Lys Thr Ala  Asp Arg Gln Ser Arg  Leu Lys Asp 
    2825                 2830                 2835             


Cys Met  Gln Lys Ala Gln Lys  Tyr Gln Trp His Val  Glu Asp Leu 
    2840                 2845                 2850             


Val Pro  Trp Ile Glu Asp Cys  Lys Ala Lys Met Ser  Glu Leu Arg 
    2855                 2860                 2865             


Val Thr  Leu Asp Pro Val Gln  Leu Glu Ser Ser Leu  Leu Arg Ser 
    2870                 2875                 2880             


Lys Ala  Met Leu Asn Glu Val  Glu Lys Arg Arg Ser  Leu Leu Glu 
    2885                 2890                 2895             


Ile Leu  Asn Ser Ala Ala Asp  Ile Leu Ile Asn Ser  Ser Glu Ala 
    2900                 2905                 2910             


Asp Glu  Asp Gly Ile Arg Asp  Glu Lys Ala Gly Ile  Asn Gln Asn 
    2915                 2920                 2925             


Met Asp  Ala Val Thr Glu Glu  Leu Gln Ala Lys Thr  Gly Ser Leu 
    2930                 2935                 2940             


Glu Glu  Met Thr Gln Arg Leu  Arg Glu Phe Gln Glu  Ser Phe Lys 
    2945                 2950                 2955             


Asn Ile  Glu Lys Lys Val Glu  Gly Ala Lys His Gln  Leu Glu Ile 
    2960                 2965                 2970             


Phe Asp  Ala Leu Gly Ser Gln  Ala Cys Ser Asn Lys  Asn Leu Glu 
    2975                 2980                 2985             


Lys Leu  Arg Ala Gln Gln Glu  Val Leu Gln Ala Leu  Glu Pro Gln 
    2990                 2995                 3000             


Val Asp  Tyr Leu Arg Asn Phe  Thr Gln Gly Leu Val  Glu Asp Ala 
    3005                 3010                 3015             


Pro Asp  Gly Ser Asp Ala Ser  Gln Leu Leu His Gln  Ala Glu Val 
    3020                 3025                 3030             


Ala Gln  Gln Glu Phe Leu Glu  Val Lys Gln Arg Val  Asn Ser Gly 
    3035                 3040                 3045             


Cys Val  Met Met Glu Asn Lys  Leu Glu Gly Ile Gly  Gln Phe His 
    3050                 3055                 3060             


Cys Arg  Val Arg Glu Met Phe  Ser Gln Leu Ala Asp  Leu Asp Asp 
    3065                 3070                 3075             


Glu Leu  Asp Gly Met Gly Ala  Ile Gly Arg Asp Thr  Asp Ser Leu 
    3080                 3085                 3090             


Gln Ser  Gln Ile Glu Asp Val  Arg Leu Phe Leu Asn  Lys Ile His 
    3095                 3100                 3105             


Val Leu  Lys Leu Asp Ile Glu  Ala Ser Glu Ala Glu  Cys Arg His 
    3110                 3115                 3120             


Met Leu  Glu Glu Glu Gly Thr  Leu Asp Leu Leu Gly  Leu Lys Arg 
    3125                 3130                 3135             


Glu Leu  Glu Ala Leu Asn Lys  Gln Cys Gly Lys Leu  Thr Glu Arg 
    3140                 3145                 3150             


Gly Lys  Ala Arg Gln Glu Gln  Leu Glu Leu Thr Leu  Gly Arg Val 
    3155                 3160                 3165             


Glu Asp  Phe Tyr Arg Lys Leu  Lys Gly Leu Asn Asp  Ala Thr Thr 
    3170                 3175                 3180             


Ala Ala  Glu Glu Ala Glu Ala  Leu Gln Trp Val Val  Gly Thr Glu 
    3185                 3190                 3195             


Val Glu  Ile Ile Asn Gln Gln  Leu Ala Asp Phe Lys  Met Phe Gln 
    3200                 3205                 3210             


Lys Glu  Gln Val Asp Pro Leu  Gln Met Lys Leu Gln  Gln Val Asn 
    3215                 3220                 3225             


Gly Leu  Gly Gln Gly Leu Ile  Gln Ser Ala Gly Lys  Asp Cys Asp 
    3230                 3235                 3240             


Val Gln  Gly Leu Glu His Asp  Met Glu Glu Ile Asn  Ala Arg Trp 
    3245                 3250                 3255             


Asn Thr  Leu Asn Lys Lys Val  Ala Gln Arg Ile Ala  Gln Leu Gln 
    3260                 3265                 3270             


Glu Ala  Leu Leu His Cys Gly  Lys Phe Gln Asp Ala  Leu Glu Pro 
    3275                 3280                 3285             


Leu Leu  Ser Trp Leu Ala Asp  Thr Glu Glu Leu Ile  Ala Asn Gln 
    3290                 3295                 3300             


Lys Pro  Pro Ser Ala Glu Tyr  Lys Val Val Lys Ala  Gln Ile Gln 
    3305                 3310                 3315             


Glu Gln  Lys Leu Leu Gln Arg  Leu Leu Asp Asp Arg  Lys Ala Thr 
    3320                 3325                 3330             


Val Asp  Met Leu Gln Ala Glu  Gly Gly Arg Ile Ala  Gln Ser Ala 
    3335                 3340                 3345             


Glu Leu  Ala Asp Arg Glu Lys  Ile Thr Gly Gln Leu  Glu Ser Leu 
    3350                 3355                 3360             


Glu Ser  Arg Trp Thr Glu Leu  Leu Ser Lys Ala Ala  Ala Arg Gln 
    3365                 3370                 3375             


Lys Gln  Leu Glu Asp Ile Leu  Val Leu Ala Lys Gln  Phe His Glu 
    3380                 3385                 3390             


Thr Ala  Glu Pro Ile Ser Asp  Phe Leu Ser Val Thr  Glu Lys Lys 
    3395                 3400                 3405             


Leu Ala  Asn Ser Glu Pro Val  Gly Thr Gln Thr Ala  Lys Ile Gln 
    3410                 3415                 3420             


Gln Gln  Ile Ile Arg His Lys  Ala Leu Glu Glu Asp  Ile Glu Asn 
    3425                 3430                 3435             


His Ala  Thr Asp Val His Gln  Ala Val Lys Ile Gly  Gln Ser Leu 
    3440                 3445                 3450             


Ser Ser  Leu Thr Ser Pro Ala  Glu Gln Gly Val Leu  Ser Glu Lys 
    3455                 3460                 3465             


Ile Asp  Ser Leu Gln Ala Arg  Tyr Ser Glu Ile Gln  Asp Arg Cys 
    3470                 3475                 3480             


Cys Arg  Lys Ala Ala Leu Leu  Asp Gln Ala Leu Ser  Asn Ala Arg 
    3485                 3490                 3495             


Leu Phe  Gly Glu Asp Glu Val  Glu Val Leu Asn Trp  Leu Ala Glu 
    3500                 3505                 3510             


Val Glu  Asp Lys Leu Ser Ser  Val Phe Val Lys Asp  Phe Lys Gln 
    3515                 3520                 3525             


Asp Val  Leu His Arg Gln His  Ala Asp His Leu Ala  Leu Asn Glu 
    3530                 3535                 3540             


Glu Ile  Val Asn Arg Lys Lys  Asn Val Asp Gln Ala  Ile Lys Asn 
    3545                 3550                 3555             


Gly Gln  Ala Leu Leu Lys Gln  Thr Thr Gly Glu Glu  Val Leu Leu 
    3560                 3565                 3570             


Ile Gln  Glu Lys Leu Asp Gly  Ile Lys Thr Arg Tyr  Ala Asp Ile 
    3575                 3580                 3585             


Thr Val  Thr Ser Ser Lys Ala  Leu Arg Thr Leu Glu  Gln Ala Arg 
    3590                 3595                 3600             


Gln Leu  Ala Thr Lys Phe Gln  Ser Thr Tyr Glu Glu  Leu Thr Gly 
    3605                 3610                 3615             


Trp Leu  Arg Glu Val Glu Glu  Glu Leu Ala Thr Ser  Gly Gly Gln 
    3620                 3625                 3630             


Ser Pro  Thr Gly Glu Gln Ile  Pro Gln Phe Gln Gln  Arg Gln Lys 
    3635                 3640                 3645             


Glu Leu  Lys Lys Glu Val Met  Glu His Arg Leu Val  Leu Asp Thr 
    3650                 3655                 3660             


Val Asn  Glu Val Ser Arg Ala  Leu Leu Glu Leu Val  Pro Trp Arg 
    3665                 3670                 3675             


Ala Arg  Glu Gly Leu Asp Lys  Leu Val Ser Asp Ala  Asn Glu Gln 
    3680                 3685                 3690             


Tyr Lys  Leu Val Ser Asp Thr  Ile Gly Gln Arg Val  Asp Glu Ile 
    3695                 3700                 3705             


Asp Ala  Ala Ile Gln Arg Ser  Gln Gln Tyr Glu Gln  Ala Ala Asp 
    3710                 3715                 3720             


Ala Glu  Leu Ala Trp Val Ala  Glu Thr Lys Arg Lys  Leu Met Ala 
    3725                 3730                 3735             


Leu Gly  Pro Ile Arg Leu Glu  Gln Asp Gln Thr Thr  Ala Gln Leu 
    3740                 3745                 3750             


Gln Val  Gln Lys Ala Phe Ser  Ile Asp Ile Ile Arg  His Lys Asp 
    3755                 3760                 3765             


Ser Met  Asp Glu Leu Phe Ser  His Arg Ser Glu Ile  Phe Gly Thr 
    3770                 3775                 3780             


Cys Gly  Glu Glu Gln Lys Thr  Val Leu Gln Glu Lys  Thr Glu Ser 
    3785                 3790                 3795             


Leu Ile  Gln Gln Tyr Glu Ala  Ile Ser Leu Leu Asn  Ser Glu Arg 
    3800                 3805                 3810             


Tyr Ala  Arg Leu Glu Arg Ala  Gln Val Leu Val Asn  Gln Phe Trp 
    3815                 3820                 3825             


Glu Thr  Tyr Glu Glu Leu Ser  Pro Trp Ile Glu Glu  Thr Arg Ala 
    3830                 3835                 3840             


Leu Ile  Ala Gln Leu Pro Ser  Pro Ala Ile Asp His  Glu Gln Leu 
    3845                 3850                 3855             


Arg Gln  Gln Gln Glu Glu Met  Arg Gln Leu Arg Glu  Ser Ile Ala 
    3860                 3865                 3870             


Glu His  Lys Pro His Ile Asp  Lys Leu Leu Lys Ile  Gly Pro Gln 
    3875                 3880                 3885             


Leu Lys  Glu Leu Asn Pro Glu  Glu Gly Glu Met Val  Glu Glu Lys 
    3890                 3895                 3900             


Tyr Gln  Lys Ala Glu Asn Met  Tyr Ala Gln Ile Lys  Glu Glu Val 
    3905                 3910                 3915             


Arg Gln  Arg Ala Leu Ala Leu  Asp Glu Ala Val Ser  Gln Ser Thr 
    3920                 3925                 3930             


Gln Ile  Thr Glu Phe His Asp  Lys Ile Glu Pro Met  Leu Glu Thr 
    3935                 3940                 3945             


Leu Glu  Asn Leu Ser Ser Arg  Leu Arg Met Pro Pro  Leu Ile Pro 
    3950                 3955                 3960             


Ala Glu  Val Asp Lys Ile Arg  Glu Cys Ile Ser Asp  Asn Lys Ser 
    3965                 3970                 3975             


Ala Thr  Val Glu Leu Glu Lys  Leu Gln Pro Ser Phe  Glu Ala Leu 
    3980                 3985                 3990             


Lys Arg  Arg Gly Glu Glu Leu  Ile Gly Arg Ser Gln  Gly Ala Asp 
    3995                 4000                 4005             


Lys Asp  Leu Ala Ala Lys Glu  Ile Gln Asp Lys Leu  Asp Gln Met 
    4010                 4015                 4020             


Val Phe  Phe Trp Glu Asp Ile  Lys Ala Arg Ala Glu  Glu Arg Glu 
    4025                 4030                 4035             


Ile Lys  Phe Leu Asp Val Leu  Glu Leu Ala Glu Lys  Phe Trp Tyr 
    4040                 4045                 4050             


Asp Met  Ala Ala Leu Leu Thr  Thr Ile Lys Asp Thr  Gln Asp Ile 
    4055                 4060                 4065             


Val His  Asp Leu Glu Ser Pro  Gly Ile Asp Pro Ser  Ile Ile Lys 
    4070                 4075                 4080             


Gln Gln  Val Glu Ala Ala Glu  Thr Ile Lys Glu Glu  Thr Asp Gly 
    4085                 4090                 4095             


Leu His  Glu Glu Leu Glu Phe  Ile Arg Ile Leu Gly  Ala Asp Leu 
    4100                 4105                 4110             


Ile Phe  Ala Cys Gly Glu Thr  Glu Lys Pro Glu Val  Arg Lys Ser 
    4115                 4120                 4125             


Ile Asp  Glu Met Asn Asn Ala  Trp Glu Asn Leu Asn  Lys Thr Trp 
    4130                 4135                 4140             


Lys Glu  Arg Leu Glu Lys Leu  Glu Asp Ala Met Gln  Ala Ala Val 
    4145                 4150                 4155             


Gln Tyr  Gln Asp Thr Leu Gln  Ala Met Phe Asp Trp  Leu Asp Asn 
    4160                 4165                 4170             


Thr Val  Ile Lys Leu Cys Thr  Met Pro Pro Val Gly  Thr Asp Leu 
    4175                 4180                 4185             


Asn Thr  Val Lys Asp Gln Leu  Asn Glu Met Lys Glu  Phe Lys Val 
    4190                 4195                 4200             


Glu Val  Tyr Gln Gln Gln Ile  Glu Met Glu Lys Leu  Asn His Gln 
    4205                 4210                 4215             


Gly Glu  Leu Met Leu Lys Lys  Ala Thr Asp Glu Thr  Asp Arg Asp 
    4220                 4225                 4230             


Ile Ile  Arg Glu Pro Leu Thr  Glu Leu Lys His Leu  Trp Glu Asn 
    4235                 4240                 4245             


Leu Gly  Glu Lys Ile Ala His  Arg Gln His Lys Leu  Glu Gly Ala 
    4250                 4255                 4260             


Leu Leu  Ala Leu Gly Gln Phe  Gln His Ala Leu Glu  Glu Leu Met 
    4265                 4270                 4275             


Ser Trp  Leu Thr His Thr Glu  Glu Leu Leu Asp Ala  Gln Arg Pro 
    4280                 4285                 4290             


Ile Ser  Gly Asp Pro Lys Val  Ile Glu Val Glu Leu  Ala Lys His 
    4295                 4300                 4305             


His Val  Leu Lys Asn Asp Val  Leu Ala His Gln Ala  Thr Val Glu 
    4310                 4315                 4320             


Thr Val  Asn Lys Ala Gly Asn  Glu Leu Leu Glu Ser  Ser Ala Gly 
    4325                 4330                 4335             


Asp Asp  Ala Ser Ser Leu Arg  Ser Arg Leu Glu Ala  Met Asn Gln 
    4340                 4345                 4350             


Cys Trp  Glu Ser Val Leu Gln  Lys Thr Glu Glu Arg  Glu Gln Gln 
    4355                 4360                 4365             


Leu Gln  Ser Thr Leu Gln Gln  Ala Gln Gly Phe His  Ser Glu Ile 
    4370                 4375                 4380             


Glu Asp  Phe Leu Leu Glu Leu  Thr Arg Met Glu Ser  Gln Leu Ser 
    4385                 4390                 4395             


Ala Ser  Lys Pro Thr Gly Gly  Leu Pro Glu Thr Ala  Arg Glu Gln 
    4400                 4405                 4410             


Leu Asp  Thr His Met Glu Leu  Tyr Ser Gln Leu Lys  Ala Lys Glu 
    4415                 4420                 4425             


Glu Thr  Tyr Asn Gln Leu Leu  Asp Lys Gly Arg Leu  Met Leu Leu 
    4430                 4435                 4440             


Ser Arg  Asp Asp Ser Gly Ser  Gly Ser Lys Thr Glu  Gln Ser Val 
    4445                 4450                 4455             


Ala Leu  Leu Glu Gln Lys Trp  His Val Val Ser Ser  Lys Met Glu 
    4460                 4465                 4470             


Glu Arg  Lys Ser Lys Leu Glu  Glu Ala Leu Asn Leu  Ala Thr Glu 
    4475                 4480                 4485             


Phe Gln  Asn Ser Leu Gln Glu  Phe Ile Asn Trp Leu  Thr Leu Ala 
    4490                 4495                 4500             


Glu Gln  Ser Leu Asn Ile Ala  Ser Pro Pro Ser Leu  Ile Leu Asn 
    4505                 4510                 4515             


Thr Val  Leu Ser Gln Ile Glu  Glu His Lys Val Phe  Ala Asn Glu 
    4520                 4525                 4530             


Val Asn  Ala His Arg Asp Gln  Ile Ile Glu Leu Asp  Gln Thr Gly 
    4535                 4540                 4545             


Asn Gln  Leu Lys Phe Leu Ser  Gln Lys Gln Asp Val  Val Leu Ile 
    4550                 4555                 4560             


Lys Asn  Leu Leu Val Ser Val  Gln Ser Arg Trp Glu  Lys Val Val 
    4565                 4570                 4575             


Gln Arg  Ser Ile Glu Arg Gly  Arg Ser Leu Asp Asp  Ala Arg Lys 
    4580                 4585                 4590             


Arg Ala  Lys Gln Phe His Glu  Ala Trp Lys Lys Leu  Ile Asp Trp 
    4595                 4600                 4605             


Leu Glu  Asp Ala Glu Ser His  Leu Asp Ser Glu Leu  Glu Ile Ser 
    4610                 4615                 4620             


Asn Asp  Pro Asp Lys Ile Lys  Leu Gln Leu Ser Lys  His Lys Glu 
    4625                 4630                 4635             


Phe Gln  Lys Thr Leu Gly Gly  Lys Gln Pro Val Tyr  Asp Thr Thr 
    4640                 4645                 4650             


Ile Arg  Thr Gly Arg Ala Leu  Lys Glu Lys Thr Leu  Leu Pro Glu 
    4655                 4660                 4665             


Asp Ser  Gln Lys Leu Asp Asn  Phe Leu Gly Glu Val  Arg Asp Lys 
    4670                 4675                 4680             


Trp Asp  Thr Val Cys Gly Lys  Ser Val Glu Arg Gln  His Lys Leu 
    4685                 4690                 4695             


Glu Glu  Ala Leu Leu Phe Ser  Gly Gln Phe Met Asp  Ala Leu Gln 
    4700                 4705                 4710             


Ala Leu  Val Asp Trp Leu Tyr  Lys Val Glu Pro Gln  Leu Ala Glu 
    4715                 4720                 4725             


Asp Gln  Pro Val His Gly Asp  Leu Asp Leu Val Met  Asn Leu Met 
    4730                 4735                 4740             


Asp Ala  His Lys Val Phe Gln  Lys Glu Leu Gly Lys  Arg Thr Gly 
    4745                 4750                 4755             


Thr Val  Gln Val Leu Lys Arg  Ser Gly Arg Glu Leu  Ile Glu Asn 
    4760                 4765                 4770             


Ser Arg  Asp Asp Thr Thr Trp  Val Lys Gly Gln Leu  Gln Glu Leu 
    4775                 4780                 4785             


Ser Thr  Arg Trp Asp Thr Val  Cys Lys Leu Ser Val  Ser Lys Gln 
    4790                 4795                 4800             


Ser Arg  Leu Glu Gln Ala Leu  Lys Gln Ala Glu Val  Phe Arg Asp 
    4805                 4810                 4815             


Thr Val  His Met Leu Leu Glu  Trp Leu Ser Glu Ala  Glu Gln Thr 
    4820                 4825                 4830             


Leu Arg  Phe Arg Gly Ala Leu  Pro Asp Asp Thr Glu  Ala Leu Gln 
    4835                 4840                 4845             


Ser Leu  Ile Asp Thr His Lys  Glu Phe Met Lys Lys  Val Glu Glu 
    4850                 4855                 4860             


Lys Arg  Val Asp Val Asn Ser  Ala Val Ala Met Gly  Glu Val Ile 
    4865                 4870                 4875             


Leu Ala  Val Cys His Pro Asp  Cys Ile Thr Thr Ile  Lys His Trp 
    4880                 4885                 4890             


Ile Thr  Ile Ile Arg Ala Arg  Phe Glu Glu Val Leu  Thr Trp Ala 
    4895                 4900                 4905             


Lys Gln  His Gln Gln Arg Leu  Glu Thr Ala Leu Ser  Glu Leu Val 
    4910                 4915                 4920             


Ala Asn  Ala Glu Leu Leu Glu  Glu Leu Leu Ala Trp  Ile Gln Trp 
    4925                 4930                 4935             


Ala Glu  Thr Thr Leu Ile Gln  Arg Asp Gln Glu Pro  Ile Pro Gln 
    4940                 4945                 4950             


Asn Ile  Asp Arg Val Lys Ala  Leu Ile Ala Glu His  Gln Thr Phe 
    4955                 4960                 4965             


Met Glu  Glu Met Thr Arg Lys  Gln Pro Asp Val Asp  Arg Val Thr 
    4970                 4975                 4980             


Lys Thr  Tyr Lys Arg Lys Asn  Ile Glu Pro Thr His  Ala Pro Phe 
    4985                 4990                 4995             


Ile Glu  Lys Ser Arg Ser Gly  Gly Arg Lys Ser Leu  Ser Gln Pro 
    5000                 5005                 5010             


Thr Pro  Pro Pro Met Pro Ile  Leu Ser Gln Ser Glu  Ala Lys Asn 
    5015                 5020                 5025             


Pro Arg  Ile Asn Gln Leu Ser  Ala Arg Trp Gln Gln  Val Trp Leu 
    5030                 5035                 5040             


Leu Ala  Leu Glu Arg Gln Arg  Lys Leu Asn Asp Ala  Leu Asp Arg 
    5045                 5050                 5055             


Leu Glu  Glu Leu Lys Glu Phe  Ala Asn Phe Asp Phe  Asp Val Trp 
    5060                 5065                 5070             


Arg Lys  Lys Tyr Met Arg Trp  Met Asn His Lys Lys  Ser Arg Val 
    5075                 5080                 5085             


Met Asp  Phe Phe Arg Arg Ile  Asp Lys Asp Gln Asp  Gly Lys Ile 
    5090                 5095                 5100             


Thr Arg  Gln Glu Phe Ile Asp  Gly Ile Leu Ala Ser  Lys Phe Pro 
    5105                 5110                 5115             


Thr Thr  Lys Leu Glu Met Thr  Ala Val Ala Asp Ile  Phe Asp Arg 
    5120                 5125                 5130             


Asp Gly  Asp Gly Tyr Ile Asp  Tyr Tyr Glu Phe Val  Ala Ala Leu 
    5135                 5140                 5145             


His Pro  Asn Lys Asp Ala Tyr  Arg Pro Thr Thr Asp  Ala Asp Lys 
    5150                 5155                 5160             


Ile Glu  Asp Glu Val Thr Arg  Gln Val Ala Gln Cys  Lys Cys Ala 
    5165                 5170                 5175             


Lys Arg  Phe Gln Val Glu Gln  Ile Gly Glu Asn Lys  Tyr Arg Phe 
    5180                 5185                 5190             


Gly Asp  Ser Gln Gln Leu Arg  Leu Val Arg Ile Leu  Arg Ser Thr 
    5195                 5200                 5205             


Val Met  Val Arg Val Gly Gly  Gly Trp Met Ala Leu  Asp Glu Phe 
    5210                 5215                 5220             


Leu Val  Lys Asn Asp Pro Cys  Arg Ala Arg Gly Arg  Thr Asn Ile 
    5225                 5230                 5235             


Glu Leu  Arg Glu Lys Phe Ile  Leu Pro Glu Gly Ala  Ser Gln Gly 
    5240                 5245                 5250             


Met Thr  Pro Phe Arg Ser Arg  Gly Arg Arg Ser Lys  Pro Ser Ser 
    5255                 5260                 5265             


Arg Ala  Ala Ser Pro Thr Arg  Ser Ser Ser Ser Ala  Ser Gln Ser 
    5270                 5275                 5280             


Asn His  Ser Cys Thr Ser Met  Pro Ser Ser Pro Ala  Thr Pro Ala 
    5285                 5290                 5295             


Ser Gly  Thr Lys Val Ile Pro  Ser Ser Gly Ser Lys  Leu Lys Arg 
    5300                 5305                 5310             


Pro Thr  Pro Thr Phe His Ser  Ser Arg Thr Ser Leu  Ala Gly Asp 
    5315                 5320                 5325             


Thr Ser  Asn Ser Ser Ser Pro  Ala Ser Thr Gly Ala  Lys Thr Asn 
    5330                 5335                 5340             


Arg Ala  Asp Pro Lys Lys Ser  Ala Ser Arg Pro Gly  Ser Arg Ala 
    5345                 5350                 5355             


Gly Ser  Arg Ala Gly Ser Arg  Ala Ser Ser Arg Arg  Gly Ser Asp 
    5360                 5365                 5370             


Ala Ser  Asp Phe Asp Leu Leu  Glu Thr Gln Ser Ala  Cys Ser Asp 
    5375                 5380                 5385             


Thr Ser  Glu Ser Ser Ala Ala  Gly Gly Gln Gly Asn  Ser Arg Arg 
    5390                 5395                 5400             


Gly Leu  Asn Lys Pro Ser Lys  Ile Pro Thr Met Ser  Lys Lys Thr 
    5405                 5410                 5415             


Thr Thr  Ala Ser Pro Arg Thr  Pro Gly Pro Lys Arg  
    5420                 5425                 5430 


<210> 437
<211> 11884
<212> DNA
<213> Homo sapiens

<400> 437
cgcgcaggga gagagcggag ggggaggcga cgcgcgccgg gaggaggggg gacgcagtgg       60

gcggagcgga gacagcacct tcggagataa tcctttctcc tgccgcagag cagaggagcg      120

gcgggagagg aacacttctc ccaggcttta gcagagccgg caggatggcg accgtggtgg      180

tggaagccac cgagccggag ccatcgggca gcatcggcaa cccggcggcg accacctcgc      240

ccagcctgtc gcaccgcttc ctagacagca agttctactt gctggtggtg gtcggcgaga      300

cggtgaccga agagcacctg aggcgtgcca tcggcaacat cgagctgggg atccgatcgt      360

gggacacaaa cctgatcgag tgcaacttgg accaagagct caaacttttc gtgtctcgac      420

actccgcgag attctctcct gaagttccag gacaaaagat cctccatcac cgaagtgacg      480

tcttagaaac tgtagttctg atcaaccctt cggatgaagc agtcagcacc gaggtgcgtt      540

tgatgatcac tgacgccgcc cgccataaac tgctggtgct caccggacag tgctttgaga      600

acactggaga gctcatcctc cagtcaggct ctttctcctt ccagaacttc atagagattt      660

tcaccgacca agagattggg gagctcctaa gcaccaccca tcctgccaac aaagccagcc      720

tcaccctctt ctgccctgag gaaggagact ggaagaactc caaccttgac agacacaatc      780

tccaagactt catcaacatc aagctcaact cagcttctat cttgccagaa atggagggac      840

tttctgagtt caccgagtac ctctcggagt ctgtcgaagt cccctccccc tttgacatcc      900

tggagccccc gacctcgggc ggatttctga agctctccaa gccttgttgt tacatttttc      960

cggggggccg cggggactct gccctgttcg cagtgaacgg attcaacatg ctcattaacg     1020

gaggatcaga aagaaagtcc tgcttctgga agctcattcg gcacttggac cgggtggact     1080

ccatcctgct cacccacatt ggggatgaca acttgcccgg gatcaacagc atgttgcaac     1140

gcaagattgc agagctggaa gaggagcggt cccagggctc caccagcaac agtgactgga     1200

tgaaaaacct catctcccct gacttggggg ttgtgtttct caatgtacct gaaaatctga     1260

aaaacccaga acccaacatc aagatgaaga gaagtacaga agaagcatgc ttcaccctcc     1320

agtacctaaa caaactgtcc atgaaaccag agcctttatt tagaagtgta ggcaatgcca     1380

ttgagcctgt catcctgttc caaaaaatgg gagtgggtaa actggagatg tacgtgctta     1440

acccagtcaa aagcagcaag gaaatgcagt atttcatgca gcagtggact ggaaccaaca     1500

aagacaaggc tgaacttatc ctgcccaatg gtcaagaagt agacatcccg atttcctacc     1560

tgacttccgt ctcgtctttg attgtgtggc acccagccaa ccctgctgag aaaatcatcc     1620

gggttctgtt tcctggaaac agcacccagt acaacatcct agaagggctg gaaaaactca     1680

aacatctaga cttcctaaag cagccactgg ccacccaaaa agatctcact ggccaggtgt     1740

ccaccccccc agtgaaacag gtcaagttga aacagcgggc tgacagccga gagagtctga     1800

agccagccac aaaaccactt tccagtaaat cagtgaggaa ggagtccaaa gaggaggccc     1860

ctgaagccac aaaagccagc caagtggaaa aaacacccaa agttgaaagc aaagagaaag     1920

tgatagtgaa aaaagacaag ccaggaaagg tagaaagtaa gccatcggtg acggaaaagg     1980

aggtgcccag caaagaggag cagtcgcccg tcaaagctga ggtggctgag aaggcggcca     2040

cggagagcaa acccaaagtc accaaagaca aagtggtaaa aaaggaaata aagacaaaac     2100

ccgaagaaaa gaaagaggag aagcccaaga aggaagtggc taaaaaggaa gacaaaactc     2160

ccctcaagaa agacgagaag cccaaaaagg aagaggcgaa gaaggagatc aagaaagaaa     2220

tcaaaaagga agagaaaaag gagctgaaga aagaggtgaa gaaggaaacg cccctgaagg     2280

acgccaagaa ggaggtgaag aaagacgaga agaaagaagt taaaaaggaa gagaaggaac     2340

ccaaaaagga gattaagaag atctccaagg acataaagaa atccactcct ctgtcagaca     2400

caaagaaacc ggctgcattg aaaccaaaag tagcaaagaa agaagagccc accaagaagg     2460

agcctattgc tgctgggaaa ctcaaggaca aggggaaggt caaagtcatt aaaaaggaag     2520

gcaagaccac agaggccgct gccacagctg ttggcactgc tgccgtggct gcagcagccg     2580

gagtagcggc cagcggtcct gccaaagaac ttgaagctga gcggtccctc atgtcgtccc     2640

ctgaggatct aaccaaggac tttgaggagc taaaggctga ggagatcgat gtagcgaagg     2700

acatcaagcc tcagctggag ctcattgaag atgaagagaa actgaaggaa accgagccgg     2760

gagaagccta cgtcattcag aaagagacgg aagtcagcaa aggttctgct gagtcacctg     2820

atgaagggat caccaccact gagggggaag gggagtgcga gcaaaccccc gaggagctgg     2880

agccagttga gaagcagggc gtggatgaca tcgagaagtt cgaggatgaa ggcgctggtt     2940

ttgaagaatc ctcagaggcc ggagactacg aagagaaggc agaaactgag gaggccgagg     3000

agccggaaga agacggggaa gacaatgtga gcgggagcgc ctcgaagcac agccccacag     3060

aagacgaaga aatcgctaag gctgaggcgg acgtacacat caaggagaag agggagtctg     3120

tggccagcgg cgatgaccgg gccgaagaag acatggatga agcgcttgag aaaggagaag     3180

ctgaacagtc tgaggaggag ggtgaggagg aggaggacaa agcagaggac gccagagagg     3240

aagaccatga gcccgacaaa actgaggctg aagattatgt gatggctgtg gttgacaagg     3300

ccgcggaggc cggagtcacc gaggatcagt atgatttcct ggggacaccg gccaagcaac     3360

ctggagtcca gtctcctagc cgagaacccg cgtcttcaat tcatgatgag accctacccg     3420

gaggctccga gagcgaggcc actgcttcag atgaggagaa tcgagaagac cagcctgagg     3480

aattcactgc tacctccgga tatactcagt ccaccatcga gatatctagt gagccgactc     3540

caatggatga gatgtccact cctcgagatg tgatgaccga cgagaccaac aatgaggaga     3600

cagagtcccc gtctcaggag ttcgtgaaca ttaccaaata cgagtcttcg ctgtactctc     3660

aggagtactc caaacctgtg gttgcatcat tcaatggatt gtcagacggg tcaaagacag     3720

acgccactga cggtagggat tacaacgctt ccgcctccac catatcacca ccttcgtcca     3780

tggaagaaga caaattcagc aagtctgctc ttcgtgacgc ttaccgccca gaagagacgg     3840

acgtgaaaac cggtgccgag ttggacatca aagatgtttc ggatgagaga cttagcccag     3900

ccaagagtcc atccctgagt ccttctccac catcacccat agagaagact cccctgggtg     3960

aacgtagcgt gaatttctct ctgacaccca acgagatcaa agcctctgca gagggagagg     4020

caacagcagt agtgtccccc ggagtgaccc aagcagtagt tgaagaacac tgtgccagtc     4080

ctgaggagaa gaccttggag gtagtgtcac cgtctcagtc tgtgacaggc agtgcgggcc     4140

acacacctta ctaccaatct cccaccgacg aaaagtccag tcacctacct acagaagtca     4200

ctgagaacgc gcaggcagtc ccggtgagct ttgaattcac tgaggccaaa gatgagaacg     4260

agaggtcgtc catcagcccc atggatgaac ctgtgcctga ctcagagtct cctatcgaga     4320

aagttctgtc tccgttacgc agccctcccc ttattggatc cgagtccgca tatgaagact     4380

tcctgagtgc ggatgacaag gctcttggca gacgttcaga aagccccttt gaagggaaga     4440

atggaaagca aggcttctca gacaaagaaa gcccagtttc tgacctgact tccgatcttt     4500

accaagacaa gcaggaagag aaaagcgcgg gcttcatacc gataaaggaa gactttagtc     4560

cagaaaagaa agccagcgat gctgaaatca tgagttctca atcagctctg gctttggatg     4620

aaaggaaact gggaggagat ggatctccaa cgcaagtaga tgtcagtcag tttggctctt     4680

tcaaagaaga caccaagatg tccatttcgg aaggcaccgt ttcagacaag tccgccacgc     4740

ctgtggatga gggcgtggcc gaagacacct attcacacat ggaaggtgtg gcctcagtgt     4800

caaccgcctc tgtggctacc agctcgtttc cagagccaac cacagatgac gtgtctcctt     4860

ctctccacgc tgaagtgggc tctccacatt ccacagaggt ggatgactcc ctgtcggtgt     4920

cggtggtgca aacaccaact actttccagg aaacagaaat gtctccgtct aaagaagagt     4980

gcccaagacc aatgtcgatt tctcctcctg acttctcccc taagacagcc aaatccagga     5040

caccagttca agatcaccga tccgaacagt cttcaatgtc tattgaattc ggtcaggaat     5100

cccccgagca ttctcttgct atggacttta gtcggcagtc tccagaccac cctactgtgg     5160

gtgctggtat gcttcacatc accgaaaatg ggccaactga ggtggactac agtccctccg     5220

atatccagga ctctagtttg tcacataaga ttccgccgac agaagagcca tcctacaccc     5280

aggataatga tctgtccgag ctcatctctg tgtctcaggt ggaggcttcc ccatccacct     5340

cttctgctca cactccttct cagatagcct ctcctcttca ggaagacact ctctctgatg     5400

tcgttcctcc cagagatatg tccttatatg cctcgcttgc gtctgagaaa gtgcagagcc     5460

tggaaggaga gaaactctct ccaaaatccg atatttctcc gctcacccct cgagagtcct     5520

cacctacata ttcacctggc ttttcagatt ctacctctgg agctaaagag agtacagcgg     5580

cttaccaaac ctcctcttcc ccaccaatag atgcagcagc cgcagagccc tacggcttcc     5640

gctcctcaat gttatttgat acaatgcagc atcacctggc cttgagtaga gatttgacca     5700

catctagtgt ggagaaggac aatggaggga agacacccgg tgactttaac tatgcctatc     5760

aaaagcccga gagcaccacc gaatccccag atgaagaaga ttatgactat gaatctcacg     5820

agaaaaccat ccaggcccac gatgtgggtg gttactacta tgagaagaca gagagaacca     5880

taaaatcccc atgtgacagt ggatactcct atgagaccat tgagaagacc accaagaccc     5940

cagaagatgg tggctactcc tgtgaaatta ccgagaaaac cactcggacc cctgaagagg     6000

gcgggtactc gtatgagatc agcgagaaga caacacgaac ccctgaagta agtggctaca     6060

cctatgagaa gaccgagagg tccagaaggc tcctcgatga cattagcaat ggctacgatg     6120

acactgagga tggtggccac acacttggcg actgtagcta ttcctacgaa accactgaga     6180

aaattaccag ctttcctgaa tctgaaagct attcctatga gacaactaca aaaacaacac     6240

ggagtccaga cacctctgca tactgttacg agaccatgga gaagatcacc aagaccccac     6300

aggcatccac atactcctat gagacctcag accgatgcta cactccagaa aggaagtccc     6360

cctcggaggc acgccaggat gttgacttgt gtctggtgtc ctcctgtgaa ttcaagcatc     6420

ccaagaccga gctctcacct tccttcatta atccaaaccc tctcgagtgg tttgctgggg     6480

aagagcccac tgaagaatct gagaagcctc tcactcagtc tggaggagcc cccccacctt     6540

caggaggaaa acaacagggc agacaatgcg atgaaactcc acccacctca gtcagtgagt     6600

cagctccatc ccagacggac tctgatgttc ccccagagac agaagagtgc ccctccatca     6660

cagctgatgc caacattgac tctgaagatg agtcagaaac catccccaca gacaaaacgg     6720

ttacgtacaa acacatggac ccgcctccag cccccatgca agaccgaagc ccttctcctc     6780

gccaccctga tgtgtccatg gtggatccag aggccttggc tattgagcag aacctaggca     6840

aggctctgaa aaaggatctg aaggagaagg ccaagaccaa gaaaccaggc acaaagacca     6900

agtcctcttc acctgtcaaa aagggtgatg ggaagtccaa gccttcagca gcttccccca     6960

aaccaggagc cttgaaggaa tcctctgaca aggtgtccag agtggcttct cccaagaaga     7020

aagagtctgt ggagaaagct atgaagacca ccaccactcc tgaggtcaaa gccacacgag     7080

gggaagagaa ggacaaggaa actaagaatg cagccaatgc ttctgcatcc aagtcagtga     7140

agactgcaac agcaggacca ggaaccacta agacggccaa gtcgtccacc gtgcctcccg     7200

gcctccctgt gtatttggac ctctgctata ttcccaacca cagcaacagt aagaatgtcg     7260

atgttgagtt tttcaagaga gtgaggtcat cttactacgt ggtgagtggg aacgaccctg     7320

ccgcggagga gcccagccgg gctgtcctgg atgccttgtt ggaagggaag gctcagtggg     7380

gaagcaacat gcaggtgact ctgatcccaa cacatgactc tgaggtgatg agggagtggt     7440

accaggagac ccacgagaag cagcaagacc tcaacatcat ggtcctagca agcagtagta     7500

cagtggtcat gcaagacgag tccttccctg catgcaagat agaactgtag aaaccgcagc     7560

cgaccacacc acaggatttg aactgtgttt ccagaaattc ctgaatttga aactaccttt     7620

tcttaaacgt ccattcatct aattacgtca ctgaacaagg acctgccaga tgctatacag     7680

tgtcatggtg atgcaaatca ctgatatttc tcaatttttg ccgaccgcta aggaaagtaa     7740

ccatattccc acaatagatt tcaagttact gcaaaattac ctacccccgt tcatctctgc     7800

tgaaatacgt ggaagccagg cactcgcaca cccaactgac ttctgctagg tattggcatt     7860

tatcttagag agagaaagag agagggaaag agagtcagcg ggaggggagg gagagcggcg     7920

ggagagaggg acaaagagac tgccggagag agagagagtg agagtgagag aggaagaatc     7980

agaaagaaaa agaatgcaag acaaaaaagg tagagagttc tgatgagatg cccagggaga     8040

aagagtgggc aggatggggt atagagaaga caccagcaac tgggtctgcg ttttcccaga     8100

ccacagcgat tcattctgtg gtctacacag gtggagtttt ccattttcac cagagtcatc     8160

agaaagagtc gatctcctaa agcttgtttc taaagaacag gaaggacgaa gcctgtcacg     8220

agggcatgag atttttcacg ccttaattaa atgcctttgc tataaaggct gcccacgcat     8280

aatgtagcaa gtgtaggctg gagaagcgag tggttggagc cccgttcaga actctcagac     8340

ttttcaaaca cgtgagtagg ttgatctaag gcatgctccc agcatttgtc tacccaagtc     8400

cacatcgagt caacccgcat gcagcaacac ccaaggccac cccagttaac tgaagcaaat     8460

accaaagcag ttgggagaac atatgggaga cattttgcct taggaagtga cttgaatgta     8520

caaagttacc cgatgcactt attttttaac gtgagacggc aagtttttaa aacatccgtg     8580

taggattgta gatactccag gcgaaggagc atgcggggag ggaaggtact agaaactcgt     8640

ctgactggcc caacagttta gtgcagagtc atgcttggtg aacgtcacca cttctgatgt     8700

acccgtggcc tctcagccag ataagttgca ccctaagtag cttctttaac gcttcaagtt     8760

taagactgaa atggcttctc taatcagaac cagggaaaca atgaatctca cggtggaagg     8820

ggttctcggc aagtgtacag tgtctgcctt cctttgtctt gcattgacta ttttaatttt     8880

tccattaatt ccaacacgtg ggaacacatg tacagaagat tttttttttt agatacatga     8940

gaacttttca tagatgaact ttctaacgaa tgttttcatt tacagaaaaa tgcaaagaaa     9000

aatttgaagc gatggtcttt ttttttaatt attattttaa gtgttttgta agacaaaaaa     9060

attgaagttt tttgaggttc tggaaagatt tgaagcctga tattgaagtc gtgatgatat     9120

ttatttaaaa acccgtcact actggaaacg gtggtacctc ccaccctttg actctcatat     9180

tatgaaagtg tgagtccgtg ctgtttgaga gtgggtaggt ggcagggtag gctactgttc     9240

agggtttcac agtgctattc cctcctcctt tcaagatttt ttcaccgtga ggtggaagag     9300

ccaagttcag aagcacccta gcgccagctt gcttgggcct tttctggaaa acattcattg     9360

aaagaaataa cagattgaaa acaaatgaat tctcagctcc tacgttcacc atgtagagag     9420

ttcagacaca atgtccgtca ctgtcatcac tgaaccacaa actcgtaacg ccagatcatg     9480

aggaaatctt tcgccaagtt tcaaacggca gatccatgta ccaggggttc agagttggca     9540

atcttctcag tgacagccat gacagctcgt tcacgctgag tttcctgcag actcttaaga     9600

tctccggagt agtgaacaat gacctcattt tattttctat gttagttatt tatttcaaaa     9660

gttacatttt agtttacttt tcgtctgtga agtctatgtt tcgcactgct gtttactctg     9720

agggtttaac aatatttctc cagggtcccc tcaccgagga cccatgcagt ctacttaatg     9780

ctgtgaatca cattttccaa atgtttaatt ttttaaagaa aattaatatt ctatttttgt     9840

taggcgtctc taggaatgca gcttttattt attttcctat ttctttccaa ctcgtaaaag     9900

ccacacatta aaggtacaga aatgtcctat atggtggaag agacattgag aacggagttc     9960

attgagtgtc agctcacttg tttctcactt caggcaagct gaacacacac aagatggcaa    10020

tctcatggta gctgttgggt tggtccacac aatacactca aagagaaaca gtttctagcc    10080

ttcttgccaa atccagacct ctggttgact tttctttcct aaaagatgga gttactgccc    10140

agttctacag cttaaattta tttagccttt tatattattt tgttttaaag atgcaaagac    10200

cttagaagaa ccatagccag ccttcagtta taaccactcg accccatacg tcttattgtt    10260

tatacagaat ccgatgggga aaacactttt ttttttcaaa actgtcactg atccactggc    10320

tgtgattcct acacaatctg gcagcaccat cctgacccct gtcctcagtg atggccatgt    10380

agccgaggac accagggtga agtacattgg ctttgcaggt agctcctgat ctcccaggca    10440

cccctcctac ctgtgtggct gatctgatct tgcttgttcc atacatacac aattagttta    10500

gaggtagcca ccacgatgga ctatgtacat ttgtggtgag agctcaaaac cgacacagac    10560

ttctagaaga tttgtgcata caatccttga tccaattgta tagattgact atttgagtgg    10620

aaggcgtttc caccctgttt aaatgatgga attctattgt gctagcactc ccgatcatga    10680

cccttttggt agtatttgta aacaaaattc tacagagact aaatcttaga gataatcctc    10740

catttcaatt ttaatcaatt ctgtcctcct tttttccaaa ccccgaaccc catgcatgct    10800

ttcccagtct tgtgatggga ctggacacag tgaccgaccc cctcgcctca aacaccattt    10860

tccatggaat tcaaaagaaa aaaatttttt ttcttaacct tacatatcat agtgaatggt    10920

ttccccggtg tatatgaatg ttttaagtgt ttccaatagc ttatgaaatt taggagcttt    10980

ctaatactcg ttttataaat ttaatcattt gctaatggaa attttaccac ctcccatttg    11040

tgttacaaat cttagctcct ggagcggcac tacaattcag gagttgtttt ttctcacctc    11100

ctctgtcatt tgtcacagga ggtccctgct tggcaatgac atttgtgagt taggataatg    11160

acgttccttc tctccttttt ttttcctttc atacttcaga tttaggagaa aaagattctg    11220

tttccacgtg agaggaactg taagctttta tcacgtaacc agctgaacaa cacaccaaaa    11280

gcagcctagg gatgagcacc gcgctttggt agcgattagg ttttattcac ctggtattaa    11340

aactattcac tatttcaaaa atccggaact tttaagaatt catttcaaag gcagcatcaa    11400

aaactgaaaa ggaagggaaa aaaaaacaac agctaataat cggcttctcc gcacgcgtgg    11460

agctcgcgaa actggagccc cggagaagtg gctctgctca gccgcccgcc cacgccgcgg    11520

cggtccttgc tttccccgca tgcgcccgca ggcagcgtgc agtcctaagc ccggctgtgg    11580

agaagctcac tctctctctt gttctgaatg gtgtttgtgt cggtctgcct ctgtgtatgg    11640

tattatgtct tataatcctg catcacttcc atcctatcca gtcatatcta atgtagaaaa    11700

attagtttcc agtgaaagta atatgtagtg cttttatggt atttgtgtgc aatatcccct    11760

cttctattga ggatatttga tgtaaaggaa aaaaaaaaag aaaaaagaaa ctgagttcca    11820

caataaaata caaagtggca aaagttcact tgtgtgttga gacatcaaaa aaaaaaaaaa    11880

aaaa                                                                 11884


<210> 438
<211> 2461
<212> PRT
<213> Homo sapiens

<400> 438
Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 
1               5                   10                  15      


Ile Gly Asn Pro Ala Ala Thr Thr Ser Pro Ser Leu Ser His Arg Phe 
            20                  25                  30          


Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Thr Val Thr 
        35                  40                  45              


Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 
    50                  55                  60                  


Ser Trp Asp Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 
65                  70                  75                  80  


Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 
                85                  90                  95      


Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 
            100                 105                 110         


Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 
        115                 120                 125             


Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 
    130                 135                 140                 


Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 
145                 150                 155                 160 


Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 
                165                 170                 175     


Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 
            180                 185                 190         


Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 
        195                 200                 205             


Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 
    210                 215                 220                 


Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 
225                 230                 235                 240 


Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 
                245                 250                 255     


Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 
            260                 265                 270         


Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 
        275                 280                 285             


Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 
    290                 295                 300                 


Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 
305                 310                 315                 320 


Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Arg Ser 
                325                 330                 335     


Gln Gly Ser Thr Ser Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro 
            340                 345                 350         


Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro 
        355                 360                 365             


Glu Pro Asn Ile Lys Met Lys Arg Ser Thr Glu Glu Ala Cys Phe Thr 
    370                 375                 380                 


Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg 
385                 390                 395                 400 


Ser Val Gly Asn Ala Ile Glu Pro Val Ile Leu Phe Gln Lys Met Gly 
                405                 410                 415     


Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys 
            420                 425                 430         


Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys 
        435                 440                 445             


Ala Glu Leu Ile Leu Pro Asn Gly Gln Glu Val Asp Ile Pro Ile Ser 
    450                 455                 460                 


Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro 
465                 470                 475                 480 


Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr 
                485                 490                 495     


Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys 
            500                 505                 510         


Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Ser Thr Pro 
        515                 520                 525             


Pro Val Lys Gln Val Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser 
    530                 535                 540                 


Leu Lys Pro Ala Thr Lys Pro Leu Ser Ser Lys Ser Val Arg Lys Glu 
545                 550                 555                 560 


Ser Lys Glu Glu Ala Pro Glu Ala Thr Lys Ala Ser Gln Val Glu Lys 
                565                 570                 575     


Thr Pro Lys Val Glu Ser Lys Glu Lys Val Ile Val Lys Lys Asp Lys 
            580                 585                 590         


Pro Gly Lys Val Glu Ser Lys Pro Ser Val Thr Glu Lys Glu Val Pro 
        595                 600                 605             


Ser Lys Glu Glu Gln Ser Pro Val Lys Ala Glu Val Ala Glu Lys Ala 
    610                 615                 620                 


Ala Thr Glu Ser Lys Pro Lys Val Thr Lys Asp Lys Val Val Lys Lys 
625                 630                 635                 640 


Glu Ile Lys Thr Lys Pro Glu Glu Lys Lys Glu Glu Lys Pro Lys Lys 
                645                 650                 655     


Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Leu Lys Lys Asp Glu Lys 
            660                 665                 670         


Pro Lys Lys Glu Glu Ala Lys Lys Glu Ile Lys Lys Glu Ile Lys Lys 
        675                 680                 685             


Glu Glu Lys Lys Glu Leu Lys Lys Glu Val Lys Lys Glu Thr Pro Leu 
    690                 695                 700                 


Lys Asp Ala Lys Lys Glu Val Lys Lys Asp Glu Lys Lys Glu Val Lys 
705                 710                 715                 720 


Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Ile Ser Lys Asp 
                725                 730                 735     


Ile Lys Lys Ser Thr Pro Leu Ser Asp Thr Lys Lys Pro Ala Ala Leu 
            740                 745                 750         


Lys Pro Lys Val Ala Lys Lys Glu Glu Pro Thr Lys Lys Glu Pro Ile 
        755                 760                 765             


Ala Ala Gly Lys Leu Lys Asp Lys Gly Lys Val Lys Val Ile Lys Lys 
    770                 775                 780                 


Glu Gly Lys Thr Thr Glu Ala Ala Ala Thr Ala Val Gly Thr Ala Ala 
785                 790                 795                 800 


Val Ala Ala Ala Ala Gly Val Ala Ala Ser Gly Pro Ala Lys Glu Leu 
                805                 810                 815     


Glu Ala Glu Arg Ser Leu Met Ser Ser Pro Glu Asp Leu Thr Lys Asp 
            820                 825                 830         


Phe Glu Glu Leu Lys Ala Glu Glu Ile Asp Val Ala Lys Asp Ile Lys 
        835                 840                 845             


Pro Gln Leu Glu Leu Ile Glu Asp Glu Glu Lys Leu Lys Glu Thr Glu 
    850                 855                 860                 


Pro Gly Glu Ala Tyr Val Ile Gln Lys Glu Thr Glu Val Ser Lys Gly 
865                 870                 875                 880 


Ser Ala Glu Ser Pro Asp Glu Gly Ile Thr Thr Thr Glu Gly Glu Gly 
                885                 890                 895     


Glu Cys Glu Gln Thr Pro Glu Glu Leu Glu Pro Val Glu Lys Gln Gly 
            900                 905                 910         


Val Asp Asp Ile Glu Lys Phe Glu Asp Glu Gly Ala Gly Phe Glu Glu 
        915                 920                 925             


Ser Ser Glu Ala Gly Asp Tyr Glu Glu Lys Ala Glu Thr Glu Glu Ala 
    930                 935                 940                 


Glu Glu Pro Glu Glu Asp Gly Glu Asp Asn Val Ser Gly Ser Ala Ser 
945                 950                 955                 960 


Lys His Ser Pro Thr Glu Asp Glu Glu Ile Ala Lys Ala Glu Ala Asp 
                965                 970                 975     


Val His Ile Lys Glu Lys Arg Glu Ser Val Ala Ser Gly Asp Asp Arg 
            980                 985                 990         


Ala Glu Glu Asp Met Asp Glu Ala  Leu Glu Lys Gly Glu  Ala Glu Gln 
        995                 1000                 1005             


Ser Glu  Glu Glu Gly Glu Glu  Glu Glu Asp Lys Ala  Glu Asp Ala 
    1010                 1015                 1020             


Arg Glu  Glu Asp His Glu Pro  Asp Lys Thr Glu Ala  Glu Asp Tyr 
    1025                 1030                 1035             


Val Met  Ala Val Val Asp Lys  Ala Ala Glu Ala Gly  Val Thr Glu 
    1040                 1045                 1050             


Asp Gln  Tyr Asp Phe Leu Gly  Thr Pro Ala Lys Gln  Pro Gly Val 
    1055                 1060                 1065             


Gln Ser  Pro Ser Arg Glu Pro  Ala Ser Ser Ile His  Asp Glu Thr 
    1070                 1075                 1080             


Leu Pro  Gly Gly Ser Glu Ser  Glu Ala Thr Ala Ser  Asp Glu Glu 
    1085                 1090                 1095             


Asn Arg  Glu Asp Gln Pro Glu  Glu Phe Thr Ala Thr  Ser Gly Tyr 
    1100                 1105                 1110             


Thr Gln  Ser Thr Ile Glu Ile  Ser Ser Glu Pro Thr  Pro Met Asp 
    1115                 1120                 1125             


Glu Met  Ser Thr Pro Arg Asp  Val Met Thr Asp Glu  Thr Asn Asn 
    1130                 1135                 1140             


Glu Glu  Thr Glu Ser Pro Ser  Gln Glu Phe Val Asn  Ile Thr Lys 
    1145                 1150                 1155             


Tyr Glu  Ser Ser Leu Tyr Ser  Gln Glu Tyr Ser Lys  Pro Val Val 
    1160                 1165                 1170             


Ala Ser  Phe Asn Gly Leu Ser  Asp Gly Ser Lys Thr  Asp Ala Thr 
    1175                 1180                 1185             


Asp Gly  Arg Asp Tyr Asn Ala  Ser Ala Ser Thr Ile  Ser Pro Pro 
    1190                 1195                 1200             


Ser Ser  Met Glu Glu Asp Lys  Phe Ser Lys Ser Ala  Leu Arg Asp 
    1205                 1210                 1215             


Ala Tyr  Arg Pro Glu Glu Thr  Asp Val Lys Thr Gly  Ala Glu Leu 
    1220                 1225                 1230             


Asp Ile  Lys Asp Val Ser Asp  Glu Arg Leu Ser Pro  Ala Lys Ser 
    1235                 1240                 1245             


Pro Ser  Leu Ser Pro Ser Pro  Pro Ser Pro Ile Glu  Lys Thr Pro 
    1250                 1255                 1260             


Leu Gly  Glu Arg Ser Val Asn  Phe Ser Leu Thr Pro  Asn Glu Ile 
    1265                 1270                 1275             


Lys Ala  Ser Ala Glu Gly Glu  Ala Thr Ala Val Val  Ser Pro Gly 
    1280                 1285                 1290             


Val Thr  Gln Ala Val Val Glu  Glu His Cys Ala Ser  Pro Glu Glu 
    1295                 1300                 1305             


Lys Thr  Leu Glu Val Val Ser  Pro Ser Gln Ser Val  Thr Gly Ser 
    1310                 1315                 1320             


Ala Gly  His Thr Pro Tyr Tyr  Gln Ser Pro Thr Asp  Glu Lys Ser 
    1325                 1330                 1335             


Ser His  Leu Pro Thr Glu Val  Thr Glu Asn Ala Gln  Ala Val Pro 
    1340                 1345                 1350             


Val Ser  Phe Glu Phe Thr Glu  Ala Lys Asp Glu Asn  Glu Arg Ser 
    1355                 1360                 1365             


Ser Ile  Ser Pro Met Asp Glu  Pro Val Pro Asp Ser  Glu Ser Pro 
    1370                 1375                 1380             


Ile Glu  Lys Val Leu Ser Pro  Leu Arg Ser Pro Pro  Leu Ile Gly 
    1385                 1390                 1395             


Ser Glu  Ser Ala Tyr Glu Asp  Phe Leu Ser Ala Asp  Asp Lys Ala 
    1400                 1405                 1410             


Leu Gly  Arg Arg Ser Glu Ser  Pro Phe Glu Gly Lys  Asn Gly Lys 
    1415                 1420                 1425             


Gln Gly  Phe Ser Asp Lys Glu  Ser Pro Val Ser Asp  Leu Thr Ser 
    1430                 1435                 1440             


Asp Leu  Tyr Gln Asp Lys Gln  Glu Glu Lys Ser Ala  Gly Phe Ile 
    1445                 1450                 1455             


Pro Ile  Lys Glu Asp Phe Ser  Pro Glu Lys Lys Ala  Ser Asp Ala 
    1460                 1465                 1470             


Glu Ile  Met Ser Ser Gln Ser  Ala Leu Ala Leu Asp  Glu Arg Lys 
    1475                 1480                 1485             


Leu Gly  Gly Asp Gly Ser Pro  Thr Gln Val Asp Val  Ser Gln Phe 
    1490                 1495                 1500             


Gly Ser  Phe Lys Glu Asp Thr  Lys Met Ser Ile Ser  Glu Gly Thr 
    1505                 1510                 1515             


Val Ser  Asp Lys Ser Ala Thr  Pro Val Asp Glu Gly  Val Ala Glu 
    1520                 1525                 1530             


Asp Thr  Tyr Ser His Met Glu  Gly Val Ala Ser Val  Ser Thr Ala 
    1535                 1540                 1545             


Ser Val  Ala Thr Ser Ser Phe  Pro Glu Pro Thr Thr  Asp Asp Val 
    1550                 1555                 1560             


Ser Pro  Ser Leu His Ala Glu  Val Gly Ser Pro His  Ser Thr Glu 
    1565                 1570                 1575             


Val Asp  Asp Ser Leu Ser Val  Ser Val Val Gln Thr  Pro Thr Thr 
    1580                 1585                 1590             


Phe Gln  Glu Thr Glu Met Ser  Pro Ser Lys Glu Glu  Cys Pro Arg 
    1595                 1600                 1605             


Pro Met  Ser Ile Ser Pro Pro  Asp Phe Ser Pro Lys  Thr Ala Lys 
    1610                 1615                 1620             


Ser Arg  Thr Pro Val Gln Asp  His Arg Ser Glu Gln  Ser Ser Met 
    1625                 1630                 1635             


Ser Ile  Glu Phe Gly Gln Glu  Ser Pro Glu His Ser  Leu Ala Met 
    1640                 1645                 1650             


Asp Phe  Ser Arg Gln Ser Pro  Asp His Pro Thr Val  Gly Ala Gly 
    1655                 1660                 1665             


Met Leu  His Ile Thr Glu Asn  Gly Pro Thr Glu Val  Asp Tyr Ser 
    1670                 1675                 1680             


Pro Ser  Asp Ile Gln Asp Ser  Ser Leu Ser His Lys  Ile Pro Pro 
    1685                 1690                 1695             


Thr Glu  Glu Pro Ser Tyr Thr  Gln Asp Asn Asp Leu  Ser Glu Leu 
    1700                 1705                 1710             


Ile Ser  Val Ser Gln Val Glu  Ala Ser Pro Ser Thr  Ser Ser Ala 
    1715                 1720                 1725             


His Thr  Pro Ser Gln Ile Ala  Ser Pro Leu Gln Glu  Asp Thr Leu 
    1730                 1735                 1740             


Ser Asp  Val Val Pro Pro Arg  Asp Met Ser Leu Tyr  Ala Ser Leu 
    1745                 1750                 1755             


Ala Ser  Glu Lys Val Gln Ser  Leu Glu Gly Glu Lys  Leu Ser Pro 
    1760                 1765                 1770             


Lys Ser  Asp Ile Ser Pro Leu  Thr Pro Arg Glu Ser  Ser Pro Thr 
    1775                 1780                 1785             


Tyr Ser  Pro Gly Phe Ser Asp  Ser Thr Ser Gly Ala  Lys Glu Ser 
    1790                 1795                 1800             


Thr Ala  Ala Tyr Gln Thr Ser  Ser Ser Pro Pro Ile  Asp Ala Ala 
    1805                 1810                 1815             


Ala Ala  Glu Pro Tyr Gly Phe  Arg Ser Ser Met Leu  Phe Asp Thr 
    1820                 1825                 1830             


Met Gln  His His Leu Ala Leu  Ser Arg Asp Leu Thr  Thr Ser Ser 
    1835                 1840                 1845             


Val Glu  Lys Asp Asn Gly Gly  Lys Thr Pro Gly Asp  Phe Asn Tyr 
    1850                 1855                 1860             


Ala Tyr  Gln Lys Pro Glu Ser  Thr Thr Glu Ser Pro  Asp Glu Glu 
    1865                 1870                 1875             


Asp Tyr  Asp Tyr Glu Ser His  Glu Lys Thr Ile Gln  Ala His Asp 
    1880                 1885                 1890             


Val Gly  Gly Tyr Tyr Tyr Glu  Lys Thr Glu Arg Thr  Ile Lys Ser 
    1895                 1900                 1905             


Pro Cys  Asp Ser Gly Tyr Ser  Tyr Glu Thr Ile Glu  Lys Thr Thr 
    1910                 1915                 1920             


Lys Thr  Pro Glu Asp Gly Gly  Tyr Ser Cys Glu Ile  Thr Glu Lys 
    1925                 1930                 1935             


Thr Thr  Arg Thr Pro Glu Glu  Gly Gly Tyr Ser Tyr  Glu Ile Ser 
    1940                 1945                 1950             


Glu Lys  Thr Thr Arg Thr Pro  Glu Val Ser Gly Tyr  Thr Tyr Glu 
    1955                 1960                 1965             


Lys Thr  Glu Arg Ser Arg Arg  Leu Leu Asp Asp Ile  Ser Asn Gly 
    1970                 1975                 1980             


Tyr Asp  Asp Thr Glu Asp Gly  Gly His Thr Leu Gly  Asp Cys Ser 
    1985                 1990                 1995             


Tyr Ser  Tyr Glu Thr Thr Glu  Lys Ile Thr Ser Phe  Pro Glu Ser 
    2000                 2005                 2010             


Glu Ser  Tyr Ser Tyr Glu Thr  Thr Thr Lys Thr Thr  Arg Ser Pro 
    2015                 2020                 2025             


Asp Thr  Ser Ala Tyr Cys Tyr  Glu Thr Met Glu Lys  Ile Thr Lys 
    2030                 2035                 2040             


Thr Pro  Gln Ala Ser Thr Tyr  Ser Tyr Glu Thr Ser  Asp Arg Cys 
    2045                 2050                 2055             


Tyr Thr  Pro Glu Arg Lys Ser  Pro Ser Glu Ala Arg  Gln Asp Val 
    2060                 2065                 2070             


Asp Leu  Cys Leu Val Ser Ser  Cys Glu Phe Lys His  Pro Lys Thr 
    2075                 2080                 2085             


Glu Leu  Ser Pro Ser Phe Ile  Asn Pro Asn Pro Leu  Glu Trp Phe 
    2090                 2095                 2100             


Ala Gly  Glu Glu Pro Thr Glu  Glu Ser Glu Lys Pro  Leu Thr Gln 
    2105                 2110                 2115             


Ser Gly  Gly Ala Pro Pro Pro  Ser Gly Gly Lys Gln  Gln Gly Arg 
    2120                 2125                 2130             


Gln Cys  Asp Glu Thr Pro Pro  Thr Ser Val Ser Glu  Ser Ala Pro 
    2135                 2140                 2145             


Ser Gln  Thr Asp Ser Asp Val  Pro Pro Glu Thr Glu  Glu Cys Pro 
    2150                 2155                 2160             


Ser Ile  Thr Ala Asp Ala Asn  Ile Asp Ser Glu Asp  Glu Ser Glu 
    2165                 2170                 2175             


Thr Ile  Pro Thr Asp Lys Thr  Val Thr Tyr Lys His  Met Asp Pro 
    2180                 2185                 2190             


Pro Pro  Ala Pro Met Gln Asp  Arg Ser Pro Ser Pro  Arg His Pro 
    2195                 2200                 2205             


Asp Val  Ser Met Val Asp Pro  Glu Ala Leu Ala Ile  Glu Gln Asn 
    2210                 2215                 2220             


Leu Gly  Lys Ala Leu Lys Lys  Asp Leu Lys Glu Lys  Ala Lys Thr 
    2225                 2230                 2235             


Lys Lys  Pro Gly Thr Lys Thr  Lys Ser Ser Ser Pro  Val Lys Lys 
    2240                 2245                 2250             


Gly Asp  Gly Lys Ser Lys Pro  Ser Ala Ala Ser Pro  Lys Pro Gly 
    2255                 2260                 2265             


Ala Leu  Lys Glu Ser Ser Asp  Lys Val Ser Arg Val  Ala Ser Pro 
    2270                 2275                 2280             


Lys Lys  Lys Glu Ser Val Glu  Lys Ala Met Lys Thr  Thr Thr Thr 
    2285                 2290                 2295             


Pro Glu  Val Lys Ala Thr Arg  Gly Glu Glu Lys Asp  Lys Glu Thr 
    2300                 2305                 2310             


Lys Asn  Ala Ala Asn Ala Ser  Ala Ser Lys Ser Val  Lys Thr Ala 
    2315                 2320                 2325             


Thr Ala  Gly Pro Gly Thr Thr  Lys Thr Ala Lys Ser  Ser Thr Val 
    2330                 2335                 2340             


Pro Pro  Gly Leu Pro Val Tyr  Leu Asp Leu Cys Tyr  Ile Pro Asn 
    2345                 2350                 2355             


His Ser  Asn Ser Lys Asn Val  Asp Val Glu Phe Phe  Lys Arg Val 
    2360                 2365                 2370             


Arg Ser  Ser Tyr Tyr Val Val  Ser Gly Asn Asp Pro  Ala Ala Glu 
    2375                 2380                 2385             


Glu Pro  Ser Arg Ala Val Leu  Asp Ala Leu Leu Glu  Gly Lys Ala 
    2390                 2395                 2400             


Gln Trp  Gly Ser Asn Met Gln  Val Thr Leu Ile Pro  Thr His Asp 
    2405                 2410                 2415             


Ser Glu  Val Met Arg Glu Trp  Tyr Gln Glu Thr His  Glu Lys Gln 
    2420                 2425                 2430             


Gln Asp  Leu Asn Ile Met Val  Leu Ala Ser Ser Ser  Thr Val Val 
    2435                 2440                 2445             


Met Gln  Asp Glu Ser Phe Pro  Ala Cys Lys Ile Glu  Leu 
    2450                 2455                 2460     


<210> 439
<211> 1461
<212> DNA
<213> Homo sapiens

<400> 439
ccttcgcgcc ctttggcaag ctcggactca tcttctgggg attgccgcag tgacccagta       60

atgggaaggg attgatttcc accttgcggg gtatggggcg ctcttaggag gactctggag      120

aagtagttgt cctgggagag gagcgatctt aatcctgctg catgacggga ggacaaaatg      180

cgacgctgca gctattttcc aaaggacgtt acggtgtttg ataaggacga taagtctgaa      240

ccaatcagag tccttgtgac tggagcagct ggtcaaattg catattcact gctgtacagt      300

attggaaatg gatctgtctt tggtaaagat cagcctataa ttcttgtgct gttggatatc      360

acccccatga tgggtgtcct ggacggtgtc ctaatggaac tgcaagactg tgcccttccc      420

ctcctgaaag atgtcatcgc aacagataaa gaagacgttg ccttcaaaga cctggatgtg      480

gccattcttg tgggctccat gccaagaagg gaaggcatgg agagaaaaga tttactgaaa      540

gcaaatgtga aaatcttcaa atcccagggt gcagccttag ataaatacgc caagaagtca      600

gttaaggtta ttgttgtggg taatccagcc aataccaact gcctgactgc ttccaagtca      660

gctccatcca tccccaagga gaacttcagt tgcttgactc gtttggatca caaccgagct      720

aaagctcaaa ttgctcttaa acttggtgtg actgctaatg atgtaaagaa tgtcattatc      780

tggggaaacc attcctcgac tcagtatcca gatgtcaacc atgccaaggt gaaattgcaa      840

ggaaaggaag ttggtgttta tgaagctctg aaagatgaca gctggctcaa gggagaattt      900

gtcacgactg tgcagcagcg tggcgctgct gtcatcaagg ctcgaaaact atccagtgcc      960

atgtctgctg caaaagccat ctgtgaccac gtcagggaca tctggtttgg aaccccagag     1020

ggagagtttg tgtccatggg tgttatctct gatggcaact cctatggtgt tcctgatgat     1080

ctgctctact cattccctgt tgtaatcaag aataagacct ggaagtttgt tgaaggtctc     1140

cctattaatg atttctcacg tgagaagatg gatcttactg caaaggaact gacagaagaa     1200

aaagaaagtg cttttgaatt tctttcctct gcctgactag acaatgatgt tactaaatgc     1260

ttcaaagctg aagaatctaa atgtcgtctt tgactcaagt accaaataat aataatgcta     1320

tacttaaatt acttgtgaaa aacaacacat tttaaagatt acgtgcttct tggtacaggt     1380

ttgtgaatga cagtttatcg tcatgctgtt agtgtgcatt ctaaataaat atatattcaa     1440

atgaaaaaaa aaaaaaaaaa a                                               1461


<210> 440
<211> 352
<212> PRT
<213> Homo sapiens

<400> 440
Met Arg Arg Cys Ser Tyr Phe Pro Lys Asp Val Thr Val Phe Asp Lys 
1               5                   10                  15      


Asp Asp Lys Ser Glu Pro Ile Arg Val Leu Val Thr Gly Ala Ala Gly 
            20                  25                  30          


Gln Ile Ala Tyr Ser Leu Leu Tyr Ser Ile Gly Asn Gly Ser Val Phe 
        35                  40                  45              


Gly Lys Asp Gln Pro Ile Ile Leu Val Leu Leu Asp Ile Thr Pro Met 
    50                  55                  60                  


Met Gly Val Leu Asp Gly Val Leu Met Glu Leu Gln Asp Cys Ala Leu 
65                  70                  75                  80  


Pro Leu Leu Lys Asp Val Ile Ala Thr Asp Lys Glu Asp Val Ala Phe 
                85                  90                  95      


Lys Asp Leu Asp Val Ala Ile Leu Val Gly Ser Met Pro Arg Arg Glu 
            100                 105                 110         


Gly Met Glu Arg Lys Asp Leu Leu Lys Ala Asn Val Lys Ile Phe Lys 
        115                 120                 125             


Ser Gln Gly Ala Ala Leu Asp Lys Tyr Ala Lys Lys Ser Val Lys Val 
    130                 135                 140                 


Ile Val Val Gly Asn Pro Ala Asn Thr Asn Cys Leu Thr Ala Ser Lys 
145                 150                 155                 160 


Ser Ala Pro Ser Ile Pro Lys Glu Asn Phe Ser Cys Leu Thr Arg Leu 
                165                 170                 175     


Asp His Asn Arg Ala Lys Ala Gln Ile Ala Leu Lys Leu Gly Val Thr 
            180                 185                 190         


Ala Asn Asp Val Lys Asn Val Ile Ile Trp Gly Asn His Ser Ser Thr 
        195                 200                 205             


Gln Tyr Pro Asp Val Asn His Ala Lys Val Lys Leu Gln Gly Lys Glu 
    210                 215                 220                 


Val Gly Val Tyr Glu Ala Leu Lys Asp Asp Ser Trp Leu Lys Gly Glu 
225                 230                 235                 240 


Phe Val Thr Thr Val Gln Gln Arg Gly Ala Ala Val Ile Lys Ala Arg 
                245                 250                 255     


Lys Leu Ser Ser Ala Met Ser Ala Ala Lys Ala Ile Cys Asp His Val 
            260                 265                 270         


Arg Asp Ile Trp Phe Gly Thr Pro Glu Gly Glu Phe Val Ser Met Gly 
        275                 280                 285             


Val Ile Ser Asp Gly Asn Ser Tyr Gly Val Pro Asp Asp Leu Leu Tyr 
    290                 295                 300                 


Ser Phe Pro Val Val Ile Lys Asn Lys Thr Trp Lys Phe Val Glu Gly 
305                 310                 315                 320 


Leu Pro Ile Asn Asp Phe Ser Arg Glu Lys Met Asp Leu Thr Ala Lys 
                325                 330                 335     


Glu Leu Thr Glu Glu Lys Glu Ser Ala Phe Glu Phe Leu Ser Ser Ala 
            340                 345                 350         


<210> 441
<211> 1520
<212> DNA
<213> Homo sapiens

<400> 441
gccgcgcggg gccatttccg ctgctgcttc tgtgagtttt tccggtgcac gcgagtgctt       60

ctgaaacgtc agctgcgctc ccctaggagt gctgagcccg cggaaccgca gccatgactg      120

aggctgatgt gaatccaaag gcctatcccc ttgccgatgc ccacctcacc aagaagctac      180

tggacctcgt tcagcagtca tgtaactata agcagcttcg gaaaggagcc aatgaggcca      240

ccaaaaccct caacaggggc atctctgagt tcatcgtgat ggctgcagac gccgagccac      300

tggagatcat tctgcacctg ccgctgctgt gtgaagacaa gaatgtgccc tacgtgtttg      360

tgcgctccaa gcaggccctg gggagagcct gtggggtctc caggcctgtc atcgcctgtt      420

ctgtcaccat caaagaaggc tcgcagctga aacagcagat ccaatccatt cagcagtcca      480

ttgaaaggct cttagtctaa acctgtggcc tctgccacgt gctccctgcc agcttccccc      540

ctgaggttgt gtatcatatt atctgtgtta gcatgtagta ttttcagcta ctctctattg      600

ttataaaatg tagtactaaa tctggtttct ggatttttgt gttgtttttg ttctgtttta      660

cagggttgct atcccccttc ctttcctccc tccctctgcc atccttcatc cttttatcct      720

ccctttttgg aacaagtgtt cagagcagac agaagcaggg tggtggcacc gttgaaaggc      780

agaaagagcc aggagaaagc tgatggagcc aggacagaga tctggttcca gctttcagcc      840

actagcttcc tgttgtgtgc ggggtgtggt ggaattaaac agcattcatt gtgtgtccct      900

gtgcctggca cacagaatca ttcatacgtg ttcaagtgat caaggggttt catttgctct      960

tgggggatta ggtatcattt ggggaggaag catgtgttct gtgaggttgt tcggctatgt     1020

ccaagtgtcg tttactaatg tacccctgct gtttgctttt ggtaatgtga tgttgatgtt     1080

ctccccctac ccacaaccat gcccttgagg gtagcagggc agcagcatac caaagagatg     1140

tgctgcagga ctccggaggc agcctgggtg ggtgagccat ggggcagttg acctgggtct     1200

tgaaagagtc gggagtgaca agctcagaga gcatgaactg atgctggcat gaaggattcc     1260

aggaagatca tggagacctg gctggtagct gtaacagaga tggtggagtc caaggaaaca     1320

gcctgtctct ggtgaatggg actttctttg gtggacactt ggcaccagct ctgagagccc     1380

ttcccctgtg tcctgccacc atgtgggtca gatgtactct ctgtcacatg aggagagtgc     1440

tagttcatgt gttctccatt cttgtgagca tcctaataaa tctgttccat tttgatgaca     1500

aaaaaaaaaa aaaaaaaaaa                                                 1520


<210> 442
<211> 128
<212> PRT
<213> Homo sapiens

<400> 442
Met Thr Glu Ala Asp Val Asn Pro Lys Ala Tyr Pro Leu Ala Asp Ala 
1               5                   10                  15      


His Leu Thr Lys Lys Leu Leu Asp Leu Val Gln Gln Ser Cys Asn Tyr 
            20                  25                  30          


Lys Gln Leu Arg Lys Gly Ala Asn Glu Ala Thr Lys Thr Leu Asn Arg 
        35                  40                  45              


Gly Ile Ser Glu Phe Ile Val Met Ala Ala Asp Ala Glu Pro Leu Glu 
    50                  55                  60                  


Ile Ile Leu His Leu Pro Leu Leu Cys Glu Asp Lys Asn Val Pro Tyr 
65                  70                  75                  80  


Val Phe Val Arg Ser Lys Gln Ala Leu Gly Arg Ala Cys Gly Val Ser 
                85                  90                  95      


Arg Pro Val Ile Ala Cys Ser Val Thr Ile Lys Glu Gly Ser Gln Leu 
            100                 105                 110         


Lys Gln Gln Ile Gln Ser Ile Gln Gln Ser Ile Glu Arg Leu Leu Val 
        115                 120                 125             


<210> 443
<211> 4255
<212> DNA
<213> Homo sapiens

<400> 443
ggtctgcgcg caggtgccgc tcggcgcccg gcccgcccgt tccgccgctg tcgccgccgt       60

cgtgcgtgcc gctcggcgga ggggacgggc ctgcgttctc tcctccttcc tccccgcctc      120

cagctgccgg caggaccttt ctctcgctgc cgctgggacc ccgtgtcatc gcccaggccg      180

agcacggaaa tctactttct tcaatgtgtt aaccaatagt caggcttcag cagaaaactt      240

cccgttctgc actattgatc ctaatgagag cagagtacct gtgccagatg aaaggtttga      300

ctttctttgt caataccaca aaccagcaag caaaattcct gcctttctaa atgtggtgga      360

tattgctggc cttgtgaaag gagctcacaa tgggcagggc ctggggaatg cttttttatc      420

tcatattagt gcctgtgatg gcatctttca tctaacacgt gcttttgaag atgatgatat      480

cacgcacgtt gaaggaagtg tagatcctat tcgagatata gaaataatac atgaagagct      540

tcagcttaaa gatgaggaaa tgattgggcc cattatagat aaactagaaa aggtggctgt      600

gagaggagga gataaaaaac taaaacctga atatgatata atgtgcaaag taaaatcctg      660

ggttatagat caaaagaaac ctgttcgctt ctatcatgat tggaatgaca aagagattga      720

agtgttgaat aaacacttat ttttgacttc aaaaccaatg gtctacttgg ttaatctttc      780

tgaaaaagac tacattagaa agaaaaacaa atggttgata aaaattaaag agtgggtgga      840

caagtatgac ccaggtgctt tggtcattcc ttttagtggg gccttggaac tcaagttgca      900

agaattgagt gctgaggaga gacagaagta tctggaagcg aacatgacac aaagtgcttt      960

gccaaagatc attaaggctg ggtttgcagc actccaacta gaatactttt tcactgcagg     1020

cccagatgaa gtgcgtgcat ggaccatcag gaaagggact aaggctcctc aggctgcagg     1080

aaagattcac acagattttg aaaagggatt cattatggct gaagtaatga aatacgaaga     1140

ttttaaagag gaaggttctg aaaatgcagt caaggctgct ggaaagtaca gacaacaagg     1200

cagaaattat attgttgaag atggagatat tatcttcttc aaatttaaca cacctcaaca     1260

accgaagaag aaataaaatt tagttattgc tcagataaac atacaacttc caaaaggcat     1320

ctgattttta aaaaattaaa atttctgaaa accaatgcga caaataaagt tggggagatg     1380

ggaatctttg acaaacaaat tatttttatt tgttttaaaa ttaaaatact gtgtaccccc     1440

ccccccccat gaaatgcagg ttcactaaat gtgaacagct ttgcttttca cgtgattaag     1500

accctactcc aaattgtaga agcttttcag gaaccatatt actctcatga tacttcatta     1560

atctccatca tgtatgccaa gcctgacaca tttgacagtg aggacaatgt ggcttgctcc     1620

tttttgaatc tacagataat gcatgtttta cagtactcca gatgtctaca ctcaataaaa     1680

catttgacaa aaccagcctt ggtgtgtttg gggatgtctg tattgactga ctgtggtgtg     1740

ctgaatgcga tacggcacct ggtggttgct gattacagaa ttttaaggcg tgtgtatgac     1800

acagtaactg gcagtgtggg gcagctgcaa ttgtatctta aaagtgagtc tttcatggga     1860

atcagaagaa tagtatacca gggatttgtc tcaaaaaagt taattaattt atagatcaac     1920

atttattgaa agatgatagc aatgatatta tgagggatat gagataggtg actgaccaca     1980

aagaagaaaa ttctgtctca aaaattaaag aattttgttt gttattgttg ttctgaccat     2040

attgaaaaga ggttcacttt taatctttcc tttgaaatta ttaaattgta aaaactgacc     2100

cattgatgtc tggtgggtta tgttttgctt caattcagca atgtgtataa aagttcctac     2160

actgattttg aaatactaag atcagacttt gaaaatttta aaaattcttt cattcttact     2220

tttcagatat ttgagagcag tcgaagtggt agtatgggta agttaagcac ttcttaacat     2280

tgtagcagaa aattccaaaa gaaagactag aacaaattgg taatttggag accctttgcc     2340

acttagcctt ctcttgtgat gatggcctga aagctctctc ggccctgagc ctccctttct     2400

ctcccatgtt tccattcctg tgagacctcc cttccttgtc cttgtcctct gcccttttgt     2460

gctcttctgt gatcacagga ccatttccat ggaatgcaga ttcataccca gccagccttt     2520

gcctctactg tatcgctttg ggactttaaa gatgcagaag tattagaaca cacacaaact     2580

taaaatggaa agttaccaaa tgtagcacta gaggcaagaa aaggggtgat tttttaaaga     2640

tttggctata cttaagatat ttaaagagga tgaggttgag tcgtgagtat aatttagaag     2700

ctctccagtg agtatttttt tagtatcaaa tagtgatctt cttttgctaa cataaaaatg     2760

agtaaactac agcagagaaa taagaataaa actaatgaag ggttttttaa aagaactaaa     2820

taaaacaaat aaaactaggc tacaggtata gctgaccaag tttgctgtga aaaatccttg     2880

ttatatctat ttctgtattg gagtaatgtg tagattagtg gattgttagg gatttcagca     2940

gtataagaaa gaatcaaata tcttgctttt gggtcttctc caaagtaaat tgcatggact     3000

tcttaaagaa gtttgaaatc agtaaaaaga cattaggatc atgcaatttt actttgtcta     3060

gcttctaatg tggtaaattg cacattgtgc aacagaacca ttaataaaag aaaggagtta     3120

gttttgaggt aactgcattc attaggggct gaaaataaat gttaaaaatg tttaatttgg     3180

ttagaagttc tacaacattg tatgtacata tacaaaattt cattttctct gaaagtcgag     3240

aattccaaga actgttacat ataatcatat atatgcctat atctaaacgt tttccctcct     3300

ttaatattga taaagttaat atattttagg atgttatgta aatatttttg catgtatctg     3360

tagctccatc ttaatcaaat ttatggttaa aagagatttg aggccaggcg tggaggctca     3420

cacctataat cccaacactt tgggaggccg aggtgggagg atcacttgag cacaggagtt     3480

tgagaccagc ctgtgcaaca tcatgaaaca tcatctctac ataaaaaaat acatatatac     3540

aaaaattagc tgggcatcat ggcacacacc tgtagtccca gctacttagg aggctgagat     3600

gggaggattg atcgatcgct tgagcctggg aggtggaggc tactgtgagc catgatcatg     3660

ccactgcact ccagcctggg caacagagtg agaccctgtc tccaaagaga aagagaaact     3720

tgagaaggct tgtgcccaaa gcttgaagaa agattgtaat agcatttagt tgtgttttat     3780

catgttatct tcataacatg cattttgcat atggctcaga gcagagccgg atctcccaag     3840

gaagcacaaa tagtttttgt cgctaactta gttatgagtg aagcctctgt tcacttataa     3900

cttgccagtt tcattggtgg aataagtccc cttactcatg attcatcaat attcctatat     3960

taaaattcca gtttgatgtt tgtctctagt tgtctgtgta taatatttcc aaagctcctt     4020

tgtaaacccc gtctcctttc attcagagag tcagagacgg tatctcctcc tcctgcctct     4080

tctattgttc tgattagtct acttaaattc acttgatgct ctttttattt tacaagagac     4140

ttgagaaatg tcggttgttc ctaatggcaa actactttag ctgggaaaat tcatttcaac     4200

ttattttaag cttgtaaaat acactgtggt gataaaataa aagagctggg tttga          4255


<210> 444
<211> 238
<212> PRT
<213> Homo sapiens

<400> 444
Met Ile Gly Pro Ile Ile Asp Lys Leu Glu Lys Val Ala Val Arg Gly 
1               5                   10                  15      


Gly Asp Lys Lys Leu Lys Pro Glu Tyr Asp Ile Met Cys Lys Val Lys 
            20                  25                  30          


Ser Trp Val Ile Asp Gln Lys Lys Pro Val Arg Phe Tyr His Asp Trp 
        35                  40                  45              


Asn Asp Lys Glu Ile Glu Val Leu Asn Lys His Leu Phe Leu Thr Ser 
    50                  55                  60                  


Lys Pro Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg 
65                  70                  75                  80  


Lys Lys Asn Lys Trp Leu Ile Lys Ile Lys Glu Trp Val Asp Lys Tyr 
                85                  90                  95      


Asp Pro Gly Ala Leu Val Ile Pro Phe Ser Gly Ala Leu Glu Leu Lys 
            100                 105                 110         


Leu Gln Glu Leu Ser Ala Glu Glu Arg Gln Lys Tyr Leu Glu Ala Asn 
        115                 120                 125             


Met Thr Gln Ser Ala Leu Pro Lys Ile Ile Lys Ala Gly Phe Ala Ala 
    130                 135                 140                 


Leu Gln Leu Glu Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Arg Ala 
145                 150                 155                 160 


Trp Thr Ile Arg Lys Gly Thr Lys Ala Pro Gln Ala Ala Gly Lys Ile 
                165                 170                 175     


His Thr Asp Phe Glu Lys Gly Phe Ile Met Ala Glu Val Met Lys Tyr 
            180                 185                 190         


Glu Asp Phe Lys Glu Glu Gly Ser Glu Asn Ala Val Lys Ala Ala Gly 
        195                 200                 205             


Lys Tyr Arg Gln Gln Gly Arg Asn Tyr Ile Val Glu Asp Gly Asp Ile 
    210                 215                 220                 


Ile Phe Phe Lys Phe Asn Thr Pro Gln Gln Pro Lys Lys Lys 
225                 230                 235             


<210> 445
<211> 5249
<212> DNA
<213> Homo sapiens

<400> 445
cttccctccc cgactgtgcg ccgcggctgg ctcgggttcc cgggccgaca tgggcgccgc       60

cgcgtgggca cggccgctga gcgtgtcttt cctgctgctg cttctgccgc tcccggggat      120

gcctgcgggc tcctgggacc cggccggtta cctgctctac tgcccctgca tggggcgctt      180

tgggaaccag gccgatcact tcttgggctc tctggcattt gcaaagctgc taaaccgtac      240

cttggctgtc cctccttgga ttgagtacca gcatcacaag cctcctttca ccaacctcca      300

tgtgtcctac cagaagtact tcaagctgga gcccctccag gcttaccatc gggtcatcag      360

cttggaggat ttcatggaga agctggcacc cacccactgg ccccctgaga agcgggtggc      420

atactgcttt gaggtggcag cccagcgaag cccagataag aagacgtgcc ccatgaagga      480

aggaaacccc tttggcccat tctgggatca gtttcatgtg agtttcaaca agtcggagct      540

ttttacaggc atttccttca gtgcttccta cagagaacaa tggagccaga gattttctcc      600

aaaggaacat ccggtgcttg ccctgccagg agccccagcc cagttccccg tcctagagga      660

acacaggcca ctacagaagt acatggtatg gtcagacgaa atggtgaaga cgggagaggc      720

ccagattcat gcccaccttg tccggcccta tgtgggcatt catctgcgca ttggctctga      780

ctggaagaac gcctgtgcca tgctgaagga cgggactgca ggctcgcact tcatggcctc      840

tccgcagtgt gtgggctaca gccgcagcac agcggccccc ctcacgatga ctatgtgcct      900

gcctgacctg aaggagatcc agagggctgt gaagctctgg gtgaggtcgc tggatgccca      960

gtcggtctac gttgctactg attccgagag ttatgtgcct gagctccaac agctcttcaa     1020

agggaaggtg aaggtggtga gcctgaagcc tgaggtggcc caggtcgacc tgtacatcct     1080

cggccaagcc gaccacttta ttggcaactg tgtctcctcc ttcactgcct ttgtgaagcg     1140

ggagcgggac ctccagggga ggccgtcttc tttcttcggc atggacaggc cccctaagct     1200

gcgggacgag ttctgattct ggccggagca ccagaccctc tgatcctgga gggaccagag     1260

tctgagctgg tccttccagc caggcctggc agccagaggt gctccgggat tgcaaactcc     1320

tcttctcacc tgccaaagat ggagaagagt gccagggacc cctcaaggag ggagacgctc     1380

catatcccag ggcataggac ttgcaggttc ctaggagcag gagcatctcc catcgcacgt     1440

gctttctgct cttctgggaa tttctcacac tggcaaagca gtccagcctc cgtcttctgg     1500

tccactctgc tctgagcagc ctgggatgct gaactcttca gagagatttt tttatagaga     1560

gatttctata attttgatac aaggtcatga ctatcctaga actctctgtg gtttttgaaa     1620

atcattgaat tctattaatg taggtaccta aagtgacctt aactgaatgt ggatgaggct     1680

ggggctggtg tgggtctttt ggctgctttt caaggtgtcc cccaatgtgg ccctcaagag     1740

ccatccccac tgcctggcca gagccattgt tgtcccctac ttcctaggcc atttctgggg     1800

cttgggggat gaatgctgtc ctgtgctgta aacactatgc aaatggaagt tatcggttgt     1860

ggtgctgtgc agcgctctgt gggcgactaa gtgccactca cgcagcatgt tcctggcaag     1920

gagcacatac catcaagcca cactatcatg gtattgttct cacagtcttt tggtggttga     1980

tggccactgc aaacctggca ccatcagatc tcttctgatc tcttgcccca gtggggcctg     2040

gttggtagaa tgttggcatt cggttgatat ccaaagcctg ttctcccagc cgtcctcctg     2100

cagctggagc cttcaggccg tattctcacg agggaacgtt tgccaaggct ctgacctcac     2160

agaagatgcc cagggcccag aagccatcag aattatcagt ggagaagcac cttttgactc     2220

ttcccttcca atgtaatctc tgccaacacc atgaggctta aggtgctcta agtcatgagt     2280

gttttggtct caaatgctgc agttttaata atctgtgact cctgagagcc catggttttt     2340

tgaccttgtg gttctaaaat tccttgtctg acccctgtag atcttttcct tgccatgtca     2400

cctcccttgg cctttgatcc tggaaaggtg gcagagcctc cactgagcca ggcccagagc     2460

tccttgcagt gccttcttcc ttgtttacct gtgggaggaa acactttttt tgtcaggggc     2520

agcctggttc agagctcaga ggtcacactg tatcaaagat ctcaaacagc aaagtcagca     2580

tttgctgtat agagctgcca cccaactcta agcaggagaa actgtacaga aagggctttg     2640

ctatttttcc cttttgggaa aacaatgaag tgttttaagt cctgggtgga ctgagagatg     2700

gtttgcctgt ccagacttgc tctcaagcct catccagaga aggagctgca gatgagggag     2760

cccgtacact ccctgccacc actaggttgt aagcctgtag ctggctggct gatttcattt     2820

tggaattcat ttgccatcca cagccttaca ctaggcacac actttagagt ctggggctcc     2880

agtggggccc gcctaatttt ttttcccccc aagacagggc cttgctctgt ctcccaggct     2940

ggagtgcagt ggcatgatca tggcttactg cagccttgat ctcccaggct caagcgatcc     3000

ttctgcctca gcctctctgg tagctgagac tgcatgccca gctccaaatc accttgattc     3060

atatcagcag taataatcac ttgtgttctg aaagaaaggg caccagaagt tctagcaaaa     3120

ttcagttgtg ttctgtgagc tagcactttt tcctctgacc caattttctt acctataaaa     3180

tggtgataaa aaccgacagg ttgttcaaag gcccagatca gctaaagcat gtatataaga     3240

gcacgttgta aacttgaaag agacaaaggc acaaatgtgg ctgttgatta atttgactgc     3300

ttctcgttgc tcgtcacctc catgccaggc actgtgcttg ctaattgctt tatgggggca     3360

ttctcttatt tattccccag ccctgggaaa taggagctgt cattatcctt ctctttctgc     3420

acaaggaaaa attaatgccc tgagaattgt cataattttc ccaaggctgc ccagctggtg     3480

gtgttaagcc agaatttgac ctcccagagc cagtttccat tagctgccat gctctgctgc     3540

ctctaattca cagaatgcac tttctaccct gtgtgccatg gagacctcct atggaaaaat     3600

gatcagccac cttaccttct actgggtacc tgctgtgagt ctgcctatgc cagaaggatt     3660

aaggagggga ggttacccaa gaaacaaagc ctacatgccg cttacagccc ccgttggatg     3720

gttgctcagt acaacagtct tgcattcagc aggtgtttgt tcatcaccta ctatgtgtca     3780

ggctctatgc taggtactgg ggatacagga gagaatcaag cgtaaagtct ttgttctcaa     3840

ggaatttgca ttctagaaag tagaagatgt aataaatgta ctgtgggaca tgttaataag     3900

tgctataaag aaatataaag ggtttgggag caaaaagagg gagtggatct attttagatg     3960

agcccaggta agacctctct gaagagctgt catgaaggag ggagggagca cattcctggc     4020

agagaaaaca gcacgtgcaa aggccccgag actggagtgt gttcctgaag agcagccagg     4080

aggccagcat ggctggagag gcaggcatag gcagggaacc gagcagcagg tcagagcagg     4140

cgagctgaca ttctgcagcc tggacggcca tggcaggaag cttttagttg gagagataca     4200

ggaagcctcc tagggttctg agcagaagag gggcatgagc tgattcacat tctgaaggac     4260

ctctctagct ggccagtgct gaggaggttg gagagagaaa gggtgaaagc agagagacca     4320

gtgcagggct gttaacaggg ttgcaggcga gagactgggg tgctgggctc ccctagacta     4380

ggactccagt gccctcctct cccaagagac aaaggccatt gcattgaagg aggtgggaaa     4440

tgattagatt ctgaacatat gtaattattt ttcagtcttt ttcaaagata caaatattta     4500

catagtttta atcatgtaat atatacaatt taatgtccta gtgttttact taatagtgta     4560

tcatgttttc cctgttggta tgtagcctgg ataaatgctc ttaattataa aaaattctgt     4620

cgaggagtgt tccatagttt attgttttcc tattatgaga atttaggcca agtgtggtgg     4680

ctcatgcctg taatcccagc actttgcgag gccgaggtgg gcagatcact tgaggtgagg     4740

agttcaagac cagcctggcc aacatggtga attatctcta ctaaaaatac aaaaaaataa     4800

taataatagc caggcgtggt ggcacatgcc tgtattccca gctgcttggg aggctgaggc     4860

aggagaatgg cttgaacctg ggaggtggag gttgcagtga gccgagatgg tgccactgca     4920

ttccagcctg ggcaacagag cgagactcca tctcaaaaaa aaggagactt catgtgcccc     4980

caatttttca ctattgttat ttgaaaaaat atttttattt gtaagagttt ttctttattt     5040

aaaatgttca ttaataaagt tgttggacgg gaagcaaaaa aaaaaagttg tttaagataa     5100

attcccagaa gtgaatttgt tagatcaaac acttaaaact ttttgttatg gaagaattca     5160

aatataaata aaaaattgtg agtaataaaa tgaactcaca gtttcaacaa tgacccacaa     5220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                       5249


<210> 446
<211> 388
<212> PRT
<213> Homo sapiens

<400> 446
Met Gly Ala Ala Ala Trp Ala Arg Pro Leu Ser Val Ser Phe Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Pro Gly Met Pro Ala Gly Ser Trp Asp Pro Ala 
            20                  25                  30          


Gly Tyr Leu Leu Tyr Cys Pro Cys Met Gly Arg Phe Gly Asn Gln Ala 
        35                  40                  45              


Asp His Phe Leu Gly Ser Leu Ala Phe Ala Lys Leu Leu Asn Arg Thr 
    50                  55                  60                  


Leu Ala Val Pro Pro Trp Ile Glu Tyr Gln His His Lys Pro Pro Phe 
65                  70                  75                  80  


Thr Asn Leu His Val Ser Tyr Gln Lys Tyr Phe Lys Leu Glu Pro Leu 
                85                  90                  95      


Gln Ala Tyr His Arg Val Ile Ser Leu Glu Asp Phe Met Glu Lys Leu 
            100                 105                 110         


Ala Pro Thr His Trp Pro Pro Glu Lys Arg Val Ala Tyr Cys Phe Glu 
        115                 120                 125             


Val Ala Ala Gln Arg Ser Pro Asp Lys Lys Thr Cys Pro Met Lys Glu 
    130                 135                 140                 


Gly Asn Pro Phe Gly Pro Phe Trp Asp Gln Phe His Val Ser Phe Asn 
145                 150                 155                 160 


Lys Ser Glu Leu Phe Thr Gly Ile Ser Phe Ser Ala Ser Tyr Arg Glu 
                165                 170                 175     


Gln Trp Ser Gln Arg Phe Ser Pro Lys Glu His Pro Val Leu Ala Leu 
            180                 185                 190         


Pro Gly Ala Pro Ala Gln Phe Pro Val Leu Glu Glu His Arg Pro Leu 
        195                 200                 205             


Gln Lys Tyr Met Val Trp Ser Asp Glu Met Val Lys Thr Gly Glu Ala 
    210                 215                 220                 


Gln Ile His Ala His Leu Val Arg Pro Tyr Val Gly Ile His Leu Arg 
225                 230                 235                 240 


Ile Gly Ser Asp Trp Lys Asn Ala Cys Ala Met Leu Lys Asp Gly Thr 
                245                 250                 255     


Ala Gly Ser His Phe Met Ala Ser Pro Gln Cys Val Gly Tyr Ser Arg 
            260                 265                 270         


Ser Thr Ala Ala Pro Leu Thr Met Thr Met Cys Leu Pro Asp Leu Lys 
        275                 280                 285             


Glu Ile Gln Arg Ala Val Lys Leu Trp Val Arg Ser Leu Asp Ala Gln 
    290                 295                 300                 


Ser Val Tyr Val Ala Thr Asp Ser Glu Ser Tyr Val Pro Glu Leu Gln 
305                 310                 315                 320 


Gln Leu Phe Lys Gly Lys Val Lys Val Val Ser Leu Lys Pro Glu Val 
                325                 330                 335     


Ala Gln Val Asp Leu Tyr Ile Leu Gly Gln Ala Asp His Phe Ile Gly 
            340                 345                 350         


Asn Cys Val Ser Ser Phe Thr Ala Phe Val Lys Arg Glu Arg Asp Leu 
        355                 360                 365             


Gln Gly Arg Pro Ser Ser Phe Phe Gly Met Asp Arg Pro Pro Lys Leu 
    370                 375                 380                 


Arg Asp Glu Phe 
385             


<210> 447
<211> 13416
<212> DNA
<213> Homo sapiens

<400> 447
ggggcatttc cgggtccggg ccgagcgggc gcacgcgcgg gagcgggact cggcggcatg       60

gcgggctccg gagccggtgt gcgttgctcc ctgctgcggc tgcaggagac cttgtccgct      120

gcggaccgct gcggtgctgc cctggccggt catcaactga tccgcggcct ggggcaggaa      180

tgcgtcctga gcagcagccc cgcggtgctg gcattacaga catctttagt tttttccaga      240

gatttcggtt tgcttgtatt tgtccggaag tcactcaaca gtattgaatt tcgtgaatgt      300

agagaagaaa tcctaaagtt tttatgtatt ttcttagaaa aaatgggcca gaagatcgca      360

ccttactctg ttgaaattaa gaacacttgt accagtgttt atacaaaaga tagagctgct      420

aaatgtaaaa ttccagccct ggaccttctt attaagttac ttcagacttt tagaagttct      480

agactcatgg atgaatttaa aattggagaa ttatttagta aattctatgg agaacttgca      540

ttgaaaaaaa aaataccaga tacagtttta gaaaaagtat atgagctcct aggattattg      600

ggtgaagttc atcctagtga gatgataaat aatgcagaaa acctgttccg cgcttttctg      660

ggtgaactta agacccagat gacatcagca gtaagagagc ccaaactacc tgttctggca      720

ggatgtctga aggggttgtc ctcacttctg tgcaacttca ctaagtccat ggaagaagat      780

ccccagactt caagggagat ttttaatttt gtactaaagg caattcgtcc tcagattgat      840

ctgaagagat atgctgtgcc ctcagctggc ttgcgcctat ttgccctgca tgcatctcag      900

tttagcacct gccttctgga caactacgtg tctctatttg aagtcttgtt aaagtggtgt      960

gcccacacaa atgtagaatt gaaaaaagct gcactttcag ccctggaatc ctttctgaaa     1020

caggtttcta atatggtggc gaaaaatgca gaaatgcata aaaataaact gcagtacttt     1080

atggagcagt tttatggaat catcagaaat gtggattcga acaacaagga gttatctatt     1140

gctatccgtg gatatggact ttttgcagga ccgtgcaagg ttataaacgc aaaagatgtt     1200

gacttcatgt acgttgagct cattcagcgc tgcaagcaga tgttcctcac ccagacagac     1260

actggtgacg accgtgttta tcagatgcca agcttcctcc agtctgttgc aagcgtcttg     1320

ctgtaccttg acacagttcc tgaggtgtat actccagttc tggagcacct cgtggtgatg     1380

cagatagaca gtttcccaca gtacagtcca aaaatgcagc tggtgtgttg cagagccata     1440

gtgaaggtgt tcctagcttt ggcagcaaaa gggccagttc tcaggaattg cattagtact     1500

gtggtgcatc agggtttaat cagaatatgt tctaaaccag tggtccttcc aaagggccct     1560

gagtctgaat ctgaagacca ccgtgcttca ggggaagtca gaactggcaa atggaaggtg     1620

cccacataca aagactacgt ggatctcttc agacatctcc tgagctctga ccagatgatg     1680

gattctattt tagcagatga agcatttttc tctgtgaatt cctccagtga aagtctgaat     1740

catttacttt atgatgaatt tgtaaaatcc gttttgaaga ttgttgagaa attggatctt     1800

acacttgaaa tacagactgt tggggaacaa gagaatggag atgaggcgcc tggtgtttgg     1860

atgatcccaa cttcagatcc agcggctaac ttgcatccag ctaaacctaa agatttttcg     1920

gctttcatta acctggtgga attttgcaga gagattctcc ctgagaaaca agcagaattt     1980

tttgaaccat gggtgtactc attttcatat gaattaattt tgcaatctac aaggttgccc     2040

ctcatcagtg gtttctacaa attgctttct attacagtaa gaaatgccaa gaaaataaaa     2100

tatttcgagg gagttagtcc aaagagtctg aaacactctc ctgaagaccc agaaaagtat     2160

tcttgctttg ctttatttgt gaaatttggc aaagaggtgg cagttaaaat gaagcagtac     2220

aaagatgaac ttttggcctc ttgtttgacc tttcttctgt ccttgccaca caacatcatt     2280

gaactcgatg ttagagccta cgttcctgca ctgcagatgg ctttcaaact gggcctgagc     2340

tataccccct tggcagaagt aggcctgaat gctctagaag aatggtcaat ttatattgac     2400

agacatgtaa tgcagcctta ttacaaagac attctcccct gcctggatgg atacctgaag     2460

acttcagcct tgtcagatga gaccaagaat aactgggaag tgtcagctct ttctcgggct     2520

gcccagaaag gatttaataa agtggtgtta aagcatctga agaagacaaa gaacctttca     2580

tcaaacgaag caatatcctt agaagaaata agaattagag tagtacaaat gcttggatct     2640

ctaggaggac aaataaacaa aaatcttctg acagtcacgt cctcagatga gatgatgaag     2700

agctatgtgg cctgggacag agagaagcgg ctgagctttg cagtgccctt tagagagatg     2760

aaacctgtca ttttcctgga tgtgttcctg cctcgagtca cagaattagc gctcacagcc     2820

agtgacagac aaactaaagt tgcagcctgt gaacttttac atagcatggt tatgtttatg     2880

ttgggcaaag ccacgcagat gccagaaggg ggacagggag ccccacccat gtaccagctc     2940

tataagcgga cgtttcctgt gctgcttcga cttgcgtgtg atgttgatca ggtgacaagg     3000

caactgtatg agccactagt tatgcagctg attcactggt tcactaacaa caagaaattt     3060

gaaagtcagg atactgttgc cttactagaa gctatattgg atggaattgt ggaccctgtt     3120

gacagtactt taagagattt ttgtggtcgg tgtattcgag aattccttaa atggtccatt     3180

aagcaaataa caccacagca gcaggagaag agtccagtaa acaccaaatc gcttttcaag     3240

cgactttata gccttgcgct tcaccccaat gctttcaaga ggctgggagc atcacttgcc     3300

tttaataata tctacaggga attcagggaa gaagagtctc tggtggaaca gtttgtgttt     3360

gaagccttgg tgatatacat ggagagtctg gccttagcac atgcagatga gaagtcctta     3420

ggtacaattc aacagtgttg tgatgccatt gatcacctat gccgcatcat tgaaaagaag     3480

catgtttctt taaataaagc aaagaaacga cgtttgccgc gaggatttcc accttccgca     3540

tcattgtgtt tattggatct ggtcaagtgg cttttagctc attgtgggag gccccagaca     3600

gaatgtcgac acaaatccat tgaactcttt tataaattcg ttcctttatt gccaggcaac     3660

agatccccta atttgtggct gaaagatgtt ctcaaggaag aaggtgtctc ttttctcatc     3720

aacacctttg aggggggtgg ctgtggccag ccctcgggca tcctggccca gcccaccctc     3780

ttgtaccttc gggggccatt cagcctgcag gccacgctat gctggctgga cctgctcctg     3840

gccgcgttgg agtgctacaa cacgttcatt ggcgagagaa ctgtaggagc gctccaggtc     3900

ctaggtactg aagcccagtc ttcacttttg aaagcagtgg ctttcttctt agaaagcatt     3960

gccatgcatg acattatagc agcagaaaag tgctttggca ctggggcagc aggtaacaga     4020

acaagcccac aagagggaga aaggtacaac tacagcaaat gcaccgttgt ggtccggatt     4080

atggagttta ccacgactct gctaaacacc tccccggaag gatggaagct cctgaagaag     4140

gacttgtgta atacacacct gatgagagtc ctggtgcaga cgctgtgtga gcccgcaagc     4200

ataggtttca acatcggaga cgtccaggtt atggctcatc ttcctgatgt ttgtgtgaat     4260

ctgatgaaag ctctaaagat gtccccatac aaagatatcc tagagaccca tctgagagag     4320

aaaataacag cacagagcat tgaggagctt tgtgccgtca acttgtatgg ccctgacgcg     4380

caagtggaca ggagcaggct ggctgctgtt gtgtctgcct gtaaacagct tcacagagct     4440

gggcttctgc ataatatatt accgtctcag tccacagatt tgcatcattc tgttggcaca     4500

gaacttcttt ccctggttta taaaggcatt gcccctggag atgagagaca gtgtctgcct     4560

tctctagacc tcagttgtaa gcagctggcc agcggacttc tggagttagc ctttgctttt     4620

ggaggactgt gtgagcgcct tgtgagtctt ctcctgaacc cagcggtgct gtccacggcg     4680

tccttgggca gctcacaggg cagcgtcatc cacttctccc atggggagta tttctatagc     4740

ttgttctcag aaacgatcaa cacggaatta ttgaaaaatc tggatcttgc tgtattggag     4800

ctcatgcagt cttcagtgga taataccaaa atggtgagtg ccgttttgaa cggcatgtta     4860

gaccagagct tcagggagcg agcaaaccag aaacaccaag gactgaaact tgcgactaca     4920

attctgcaac actggaagaa gtgtgattca tggtgggcca aagattcccc tctcgaaact     4980

aaaatggcag tgctggcctt actggcaaaa attttacaga ttgattcatc tgtatctttt     5040

aatacaagtc atggttcatt ccctgaagtc tttacaacat atattagtct acttgctgac     5100

acaaagctgg atctacattt aaagggccaa gctgtcactc ttcttccatt cttcaccagc     5160

ctcactggag gcagtctgga ggaacttaga cgtgttctgg agcagctcat cgttgctcac     5220

ttccccatgc agtccaggga atttcctcca ggaactccgc ggttcaataa ttatgtggac     5280

tgcatgaaaa agtttctaga tgcattggaa ttatctcaaa gccctatgtt gttggaattg     5340

atgacagaag ttctttgtcg ggaacagcag catgtcatgg aagaattatt tcaatccagt     5400

ttcaggagga ttgccagaag gggttcatgt gtcacacaag taggccttct ggaaagcgtg     5460

tatgaaatgt tcaggaagga tgacccccgc ctaagtttca cacgccagtc ctttgtggac     5520

cgctccctcc tcactctgct gtggcactgt agcctggatg ctttgagaga attcttcagc     5580

acaattgtgg tggatgccat tgatgtgttg aagtccaggt ttacaaagct aaatgaatct     5640

acctttgata ctcaaatcac caagaagatg ggctactata agattctaga cgtgatgtat     5700

tctcgccttc ccaaagatga tgttcatgct aaggaatcaa aaattaatca agttttccat     5760

ggctcgtgta ttacagaagg aaatgaactt acaaagacat tgattaaatt gtgctacgat     5820

gcatttacag agaacatggc aggagagaat cagctgctgg agaggagaag actttaccat     5880

tgtgcagcat acaactgcgc catatctgtc atctgctgtg tcttcaatga gttaaaattt     5940

taccaaggtt ttctgtttag tgaaaaacca gaaaagaact tgcttatttt tgaaaatctg     6000

atcgacctga agcgccgcta taattttcct gtagaagttg aggttcctat ggaaagaaag     6060

aaaaagtaca ttgaaattag gaaagaagcc agagaagcag caaatgggga ttcagatggt     6120

ccttcctata tgtcttccct gtcatatttg gcagacagta ccctgagtga ggaaatgagt     6180

caatttgatt tctcaaccgg agttcagagc tattcataca gctcccaaga ccctagacct     6240

gccactggtc gttttcggag acgggagcag cgggacccca cggtgcatga tgatgtgctg     6300

gagctggaga tggacgagct caatcggcat gagtgcatgg cgcccctgac ggccctggtc     6360

aagcacatgc acagaagcct gggcccgcct caaggagaag aggattcagt gccaagagat     6420

cttccttctt ggatgaaatt cctccatggc aaactgggaa atccaatagt accattaaat     6480

atccgtctct tcttagccaa gcttgttatt aatacagaag aggtctttcg cccttacgcg     6540

aagcactggc ttagcccctt gctgcagctg gctgcttctg aaaacaatgg aggagaagga     6600

attcactaca tggtggttga gatagtggcc actattcttt catggacagg cttggccact     6660

ccaacagggg tccctaaaga tgaagtgtta gcaaatcgat tgcttaattt cctaatgaaa     6720

catgtctttc atccaaaaag agctgtgttt agacacaacc ttgaaattat aaagaccctt     6780

gtcgagtgct ggaaggattg tttatccatc ccttataggt taatatttga aaagttttcc     6840

ggtaaagatc ctaattctaa agacaactca gtagggattc aattgctagg catcgtgatg     6900

gccaatgacc tgcctcccta tgacccacag tgtggcatcc agagtagcga atacttccag     6960

gctttggtga ataatatgtc ctttgtaaga tataaagaag tgtatgccgc tgcagcagaa     7020

gttctaggac ttatacttcg atatgttatg gagagaaaaa acatactgga ggagtctctg     7080

tgtgaactgg ttgcgaaaca attgaagcaa catcagaata ctatggagga caagtttatt     7140

gtgtgcttga acaaagtgac caagagcttc cctcctcttg cagacaggtt catgaatgct     7200

gtgttctttc tgctgccaaa atttcatgga gtgttgaaaa cactctgtct ggaggtggta     7260

ctttgtcgtg tggagggaat gacagagctg tacttccagt taaagagcaa ggacttcgtt     7320

caagtcatga gacatagaga tgatgaaaga caaaaagtat gtttggacat aatttataag     7380

atgatgccaa agttaaaacc agtagaactc cgagaacttc tgaaccccgt tgtggaattc     7440

gtttcccatc cttctacaac atgtagggaa caaatgtata atattctcat gtggattcat     7500

gataattaca gagatccaga aagtgagaca gataatgact cccaggaaat atttaagttg     7560

gcaaaagatg tgctgattca aggattgatc gatgagaacc ctggacttca attaattatt     7620

cgaaatttct ggagccatga aactaggtta ccttcaaata ccttggaccg gttgctggca     7680

ctaaattcct tatattctcc taagatagaa gtgcactttt taagtttagc aacaaatttt     7740

ctgctcgaaa tgaccagcat gagcccagat tatccaaacc ccatgttcga gcatcctctg     7800

tcagaatgcg aatttcagga atataccatt gattctgatt ggcgtttccg aagtactgtt     7860

ctcactccga tgtttgtgga gacccaggcc tcccagggca ctctccagac ccgtacccag     7920

gaagggtccc tctcagctcg ctggccagtg gcagggcaga taagggccac ccagcagcag     7980

catgacttca cactgacaca gactgcagat ggaagaagct catttgattg gctgaccggg     8040

agcagcactg acccgctggt cgaccacacc agtccctcat ctgactcctt gctgtttgcc     8100

cacaagagga gtgaaaggtt acagagagca cccttgaagt cagtggggcc tgattttggg     8160

aaaaaaaggc tgggccttcc aggggacgag gtggataaca aagtgaaagg tgcggccggc     8220

cggacggacc tactacgact gcgcagacgg tttatgaggg accaggagaa gctcagtttg     8280

atgtatgcca gaaaaggcgt tgctgagcaa aaacgagaga aggaaatcaa gagtgagtta     8340

aaaatgaagc aggatgccca ggtcgttctg tacagaagct accggcacgg agaccttcct     8400

gacattcaga tcaagcacag cagcctcatc accccgttac aggccgtggc ccagagggac     8460

ccaataattg caaaacagct ctttagcagc ttgttttctg gaattttgaa agagatggat     8520

aaatttaaga cactgtctga aaaaaacaac atcactcaaa agttgcttca agacttcaat     8580

cgttttctta ataccacctt ctctttcttt ccaccctttg tctcttgtat tcaggacatt     8640

agctgtcagc acgcagccct gctgagcctc gacccagcgg ctgttagcgc tggttgcctg     8700

gccagcctac agcagcccgt gggcatccgc ctgctagagg aggctctgct ccgcctgctg     8760

cctgctgagc tgcctgccaa gcgagtccgt gggaaggccc gcctccctcc tgatgtcctc     8820

agatgggtgg agcttgctaa gctgtataga tcaattggag aatacgacgt cctccgtggg     8880

atttttacca gtgagatagg aacaaagcaa atcactcaga gtgcattatt agcagaagcc     8940

agaagtgatt attctgaagc tgctaagcag tatgatgagg ctctcaataa acaagactgg     9000

gtagatggtg agcccacaga agccgagaag gatttttggg aacttgcatc ccttgactgt     9060

tacaaccacc ttgctgagtg gaaatcactt gaatactgtt ctacagccag tatagacagt     9120

gagaaccccc cagacctaaa taaaatctgg agtgaaccat tttatcagga aacatatcta     9180

ccttacatga tccgcagcaa gctgaagctg ctgctccagg gagaggctga ccagtccctg     9240

ctgacattta ttgacaaagc tatgcacggg gagctccaga aggcgattct agagcttcat     9300

tacagtcaag agctgagtct gctttacctc ctgcaagatg atgttgacag agccaaatat     9360

tacattcaaa atggcattca gagttttatg cagaattatt ctagtattga tgtcctctta     9420

caccaaagta gactcaccaa attgcagtct gtacaggctt taacagaaat tcaggagttc     9480

atcagcttta taagcaaaca aggcaattta tcatctcaag ttccccttaa gagacttctg     9540

aacacctgga caaacagata tccagatgct aaaatggacc caatgaacat ctgggatgac     9600

atcatcacaa atcgatgttt ctttctcagc aaaatagagg agaagcttac ccctcttcca     9660

gaagataata gtatgaatgt ggatcaagat ggagacccca gtgacaggat ggaagtgcaa     9720

gagcaggaag aagatatcag ctccctgatc aggagttgca agttttccat gaaaatgaag     9780

atgatagaca gtgcccggaa gcagaacaat ttctcacttg ctatgaaact actgaaggag     9840

ctgcataaag agtcaaaaac cagagacgat tggctggtga gctgggtgca gagctactgc     9900

cgcctgagcc actgccggag ccggtcccag ggctgctctg agcaggtgct cactgtgctg     9960

aaaacagtct ctttgttgga tgagaacaac gtgtcaagct acttaagcaa aaatattctg    10020

gctttccgtg accagaacat tctcttgggt acaacttaca ggatcatagc gaatgctctc    10080

agcagtgagc cagcctgcct tgctgaaatc gaggaggaca aggctagaag aatcttagag    10140

ctttctggat ccagttcaga ggattcagag aaggtgatcg cgggtctgta ccagagagca    10200

ttccagcacc tctctgaggc tgtgcaggcg gctgaggagg aggcccagcc tccctcctgg    10260

agctgtgggc ctgcagctgg ggtgattgat gcttacatga cgctggcaga tttctgtgac    10320

caacagctgc gcaaggagga agagaatgca tcagttattg attctgcaga actgcaggcg    10380

tatccagcac ttgtggtgga gaaaatgttg aaagctttaa aattaaattc caatgaagcc    10440

agattgaagt ttcctagatt acttcagatt atagaacggt atccagagga gactttgagc    10500

ctcatgacaa aagagatctc ttccgttccc tgctggcagt tcatcagctg gatcagccac    10560

atggtggcct tactggacaa agaccaagcc gttgctgttc agcactctgt ggaagaaatc    10620

actgataact acccgcaggc tattgtttat cccttcatca taagcagcga aagctattcc    10680

ttcaaggata cttctactgg tcataagaat aaggagtttg tggcaaggat taaaagtaag    10740

ttggatcaag gaggagtgat tcaagatttt attaatgcct tagatcagct ctctaatcct    10800

gaactgctct ttaaggattg gagcaatgat gtaagagctg aactagcaaa aacccctgta    10860

aataaaaaaa acattgaaaa aatgtatgaa agaatgtatg cagccttggg tgacccaaag    10920

gctccaggcc tgggggcctt tagaaggaag tttattcaga cttttggaaa agaatttgat    10980

aaacattttg ggaaaggagg ttctaaacta ctgagaatga agctcagtga cttcaacgac    11040

attaccaaca tgctactttt aaaaatgaac aaagactcaa agccccctgg gaatctgaaa    11100

gaatgttcac cctggatgag cgacttcaaa gtggagttcc tgagaaatga gctggagatt    11160

cccggtcagt atgacggtag gggaaagcca ttgccagagt accacgtgcg aatcgccggg    11220

tttgatgagc gggtgacagt catggcgtct ctgcgaaggc ccaagcgcat catcatccgt    11280

ggccatgacg agagggaaca ccctttcctg gtgaagggtg gcgaggacct gcggcaggac    11340

cagcgcgtgg agcagctctt ccaggtcatg aatgggatcc tggcccaaga ctccgcctgc    11400

agccagaggg ccctgcagct gaggacctat agcgttgtgc ccatgacctc cagtgatccc    11460

agggcaccgc cgtgtgaata taaagattgg ctgacaaaaa tgtcaggaaa acatgatgtt    11520

ggagcttaca tgctaatgta taagggcgct aatcgtactg aaacagtcac gtcttttaga    11580

aaacgagaaa gtaaagtgcc tgctgatctc ttaaagcggg ccttcgtgag gatgagtaca    11640

agccctgagg ctttcctggc gctccgctcc cacttcgcca gctctcacgc tctgatatgc    11700

atcagccact ggatcctcgg gattggagac agacatctga acaactttat ggtggccatg    11760

gagactggcg gcgtgatcgg gatcgacttt gggcatgcgt ttggatccgc tacacagttt    11820

ctgccagtcc ctgagttgat gccttttcgg ctaactcgcc agtttatcaa tctgatgtta    11880

ccaatgaaag aaacgggcct tatgtacagc atcatggtac acgcactccg ggccttccgc    11940

tcagaccctg gcctgctcac caacaccatg gatgtgtttg tcaaggagcc ctcctttgat    12000

tggaaaaatt ttgaacagaa aatgctgaaa aaaggagggt catggattca agaaataaat    12060

gttgctgaaa aaaattggta cccccgacag aaaatatgtt acgctaagag aaagttagca    12120

ggtgccaatc cagcagtcat tacttgtgat gagctactcc tgggtcatga gaaggcccct    12180

gccttcagag actatgtggc tgtggcacga ggaagcaaag atcacaacat tcgtgcccaa    12240

gaaccagaga gtgggctttc agaagagact caagtgaagt gcctgatgga ccaggcaaca    12300

gaccccaaca tccttggcag aacctgggaa ggatgggagc cctggatgtg aggtctgtgg    12360

gagtctgcag atagaaagca ttacattgtt taaagaatct actatacttt ggttggcagc    12420

attccatgag ctgattttcc tgaaacacta aagagaaatg tcttttgtgc tacagtttcg    12480

tagcatgagt ttaaatcaag attatgatga gtaaatgtgt atgggttaaa tcaaagataa    12540

ggttatagta acatcaaaga ttaggtgagg tttatagaaa gatagatatc caggcttacc    12600

aaagtattaa gtcaagaata taatatgtga tcagctttca aagcatttac aagtgctgca    12660

agttagtgaa acagctgtct ccgtaaatgg aggaaatgtg gggaagcctt ggaatgccct    12720

tctggttctg gcacattgga aagcacactc agaaggcttc atcaccaaga ttttgggaga    12780

gtaaagctaa gtatagttga tgtaacattg tagaagcagc ataggaacaa taagaacaat    12840

aggtaaagct ataattatgg cttatattta gaaatgactg catttgatat tttaggatat    12900

ttttctaggt tttttccttt cattttattc tcttctagtt ttgacatttt atgatagatt    12960

tgctctctag aaggaaacgt ctttatttag gagggcaaaa attttggtca tagcattcac    13020

ttttgctatt ccaatctaca actggaagat acataaaagt gctttgcatt gaatttggga    13080

taacttcaaa aatcccatgg ttgttgttag ggatagtact aagcatttca gttccaggag    13140

aataaaagaa attcctattt gaaatgaatt cctcatttgg aggaaaaaaa gcatgcattc    13200

tagcacaaca agatgaaatt atggaataca aaagtggctc cttcccatgt gcagtccctg    13260

tccccccccg ccagtcctcc acacccaaac tgtttctgat tggcttttag ctttttgttg    13320

tttttttttt tccttctaac acttgtattt ggaggctctt ctgtgatttt gagaagtata    13380

ctcttgagtg tttaataaag tttttttcca aaagta                              13416


<210> 448
<211> 4097
<212> PRT
<213> Homo sapiens

<400> 448
Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln 
1               5                   10                  15      


Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His 
            20                  25                  30          


Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro 
        35                  40                  45              


Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly 
    50                  55                  60                  


Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu 
65                  70                  75                  80  


Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met 
                85                  90                  95      


Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr 
            100                 105                 110         


Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu 
        115                 120                 125             


Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met 
    130                 135                 140                 


Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu 
145                 150                 155                 160 


Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu 
                165                 170                 175     


Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn 
            180                 185                 190         


Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met 
        195                 200                 205             


Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu 
    210                 215                 220                 


Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu 
225                 230                 235                 240 


Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile 
                245                 250                 255     


Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu 
            260                 265                 270         


Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp 
        275                 280                 285             


Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr 
    290                 295                 300                 


Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu 
305                 310                 315                 320 


Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn 
                325                 330                 335     


Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val 
            340                 345                 350         


Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu 
        355                 360                 365             


Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met 
    370                 375                 380                 


Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr 
385                 390                 395                 400 


Asp Thr Gly Asp Asp Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser 
                405                 410                 415     


Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr 
            420                 425                 430         


Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln 
        435                 440                 445             


Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val 
    450                 455                 460                 


Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser 
465                 470                 475                 480 


Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val 
                485                 490                 495     


Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly 
            500                 505                 510         


Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val 
        515                 520                 525             


Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile 
    530                 535                 540                 


Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu 
545                 550                 555                 560 


Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val 
                565                 570                 575     


Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu 
            580                 585                 590         


Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro 
        595                 600                 605             


Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile 
    610                 615                 620                 


Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu 
625                 630                 635                 640 


Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln 
                645                 650                 655     


Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile 
            660                 665                 670         


Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro 
        675                 680                 685             


Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe 
    690                 695                 700                 


Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln 
705                 710                 715                 720 


Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu 
                725                 730                 735     


Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu 
            740                 745                 750         


Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val 
        755                 760                 765             


Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val 
    770                 775                 780                 


Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu 
785                 790                 795                 800 


Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser 
                805                 810                 815     


Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys 
            820                 825                 830         


His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu 
        835                 840                 845             


Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly 
    850                 855                 860                 


Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met 
865                 870                 875                 880 


Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val 
                885                 890                 895     


Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro 
            900                 905                 910         


Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val 
        915                 920                 925             


Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys 
    930                 935                 940                 


Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln 
945                 950                 955                 960 


Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val 
                965                 970                 975     


Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile 
            980                 985                 990         


His Trp Phe Thr Asn Asn Lys Lys  Phe Glu Ser Gln Asp  Thr Val Ala 
        995                 1000                 1005             


Leu Leu  Glu Ala Ile Leu Asp  Gly Ile Val Asp Pro  Val Asp Ser 
    1010                 1015                 1020             


Thr Leu  Arg Asp Phe Cys Gly  Arg Cys Ile Arg Glu  Phe Leu Lys 
    1025                 1030                 1035             


Trp Ser  Ile Lys Gln Ile Thr  Pro Gln Gln Gln Glu  Lys Ser Pro 
    1040                 1045                 1050             


Val Asn  Thr Lys Ser Leu Phe  Lys Arg Leu Tyr Ser  Leu Ala Leu 
    1055                 1060                 1065             


His Pro  Asn Ala Phe Lys Arg  Leu Gly Ala Ser Leu  Ala Phe Asn 
    1070                 1075                 1080             


Asn Ile  Tyr Arg Glu Phe Arg  Glu Glu Glu Ser Leu  Val Glu Gln 
    1085                 1090                 1095             


Phe Val  Phe Glu Ala Leu Val  Ile Tyr Met Glu Ser  Leu Ala Leu 
    1100                 1105                 1110             


Ala His  Ala Asp Glu Lys Ser  Leu Gly Thr Ile Gln  Gln Cys Cys 
    1115                 1120                 1125             


Asp Ala  Ile Asp His Leu Cys  Arg Ile Ile Glu Lys  Lys His Val 
    1130                 1135                 1140             


Ser Leu  Asn Lys Ala Lys Lys  Arg Arg Leu Pro Arg  Gly Phe Pro 
    1145                 1150                 1155             


Pro Ser  Ala Ser Leu Cys Leu  Leu Asp Leu Val Lys  Trp Leu Leu 
    1160                 1165                 1170             


Ala His  Cys Gly Arg Pro Gln  Thr Glu Cys Arg His  Lys Ser Ile 
    1175                 1180                 1185             


Glu Leu  Phe Tyr Lys Phe Val  Pro Leu Leu Pro Gly  Asn Arg Ser 
    1190                 1195                 1200             


Pro Asn  Leu Trp Leu Lys Asp  Val Leu Lys Glu Glu  Gly Val Ser 
    1205                 1210                 1215             


Phe Leu  Ile Asn Thr Phe Glu  Gly Gly Gly Cys Gly  Gln Pro Ser 
    1220                 1225                 1230             


Gly Ile  Leu Ala Gln Pro Thr  Leu Leu Tyr Leu Arg  Gly Pro Phe 
    1235                 1240                 1245             


Ser Leu  Gln Ala Thr Leu Cys  Trp Leu Asp Leu Leu  Leu Ala Ala 
    1250                 1255                 1260             


Leu Glu  Cys Tyr Asn Thr Phe  Ile Gly Glu Arg Thr  Val Gly Ala 
    1265                 1270                 1275             


Leu Gln  Val Leu Gly Thr Glu  Ala Gln Ser Ser Leu  Leu Lys Ala 
    1280                 1285                 1290             


Val Ala  Phe Phe Leu Glu Ser  Ile Ala Met His Asp  Ile Ile Ala 
    1295                 1300                 1305             


Ala Glu  Lys Cys Phe Gly Thr  Gly Ala Ala Gly Asn  Arg Thr Ser 
    1310                 1315                 1320             


Pro Gln  Glu Gly Glu Arg Tyr  Asn Tyr Ser Lys Cys  Thr Val Val 
    1325                 1330                 1335             


Val Arg  Ile Met Glu Phe Thr  Thr Thr Leu Leu Asn  Thr Ser Pro 
    1340                 1345                 1350             


Glu Gly  Trp Lys Leu Leu Lys  Lys Asp Leu Cys Asn  Thr His Leu 
    1355                 1360                 1365             


Met Arg  Val Leu Val Gln Thr  Leu Cys Glu Pro Ala  Ser Ile Gly 
    1370                 1375                 1380             


Phe Asn  Ile Gly Asp Val Gln  Val Met Ala His Leu  Pro Asp Val 
    1385                 1390                 1395             


Cys Val  Asn Leu Met Lys Ala  Leu Lys Met Ser Pro  Tyr Lys Asp 
    1400                 1405                 1410             


Ile Leu  Glu Thr His Leu Arg  Glu Lys Ile Thr Ala  Gln Ser Ile 
    1415                 1420                 1425             


Glu Glu  Leu Cys Ala Val Asn  Leu Tyr Gly Pro Asp  Ala Gln Val 
    1430                 1435                 1440             


Asp Arg  Ser Arg Leu Ala Ala  Val Val Ser Ala Cys  Lys Gln Leu 
    1445                 1450                 1455             


His Arg  Ala Gly Leu Leu His  Asn Ile Leu Pro Ser  Gln Ser Thr 
    1460                 1465                 1470             


Asp Leu  His His Ser Val Gly  Thr Glu Leu Leu Ser  Leu Val Tyr 
    1475                 1480                 1485             


Lys Gly  Ile Ala Pro Gly Asp  Glu Arg Gln Cys Leu  Pro Ser Leu 
    1490                 1495                 1500             


Asp Leu  Ser Cys Lys Gln Leu  Ala Ser Gly Leu Leu  Glu Leu Ala 
    1505                 1510                 1515             


Phe Ala  Phe Gly Gly Leu Cys  Glu Arg Leu Val Ser  Leu Leu Leu 
    1520                 1525                 1530             


Asn Pro  Ala Val Leu Ser Thr  Ala Ser Leu Gly Ser  Ser Gln Gly 
    1535                 1540                 1545             


Ser Val  Ile His Phe Ser His  Gly Glu Tyr Phe Tyr  Ser Leu Phe 
    1550                 1555                 1560             


Ser Glu  Thr Ile Asn Thr Glu  Leu Leu Lys Asn Leu  Asp Leu Ala 
    1565                 1570                 1575             


Val Leu  Glu Leu Met Gln Ser  Ser Val Asp Asn Thr  Lys Met Val 
    1580                 1585                 1590             


Ser Ala  Val Leu Asn Gly Met  Leu Asp Gln Ser Phe  Arg Glu Arg 
    1595                 1600                 1605             


Ala Asn  Gln Lys His Gln Gly  Leu Lys Leu Ala Thr  Thr Ile Leu 
    1610                 1615                 1620             


Gln His  Trp Lys Lys Cys Asp  Ser Trp Trp Ala Lys  Asp Ser Pro 
    1625                 1630                 1635             


Leu Glu  Thr Lys Met Ala Val  Leu Ala Leu Leu Ala  Lys Ile Leu 
    1640                 1645                 1650             


Gln Ile  Asp Ser Ser Val Ser  Phe Asn Thr Ser His  Gly Ser Phe 
    1655                 1660                 1665             


Pro Glu  Val Phe Thr Thr Tyr  Ile Ser Leu Leu Ala  Asp Thr Lys 
    1670                 1675                 1680             


Leu Asp  Leu His Leu Lys Gly  Gln Ala Val Thr Leu  Leu Pro Phe 
    1685                 1690                 1695             


Phe Thr  Ser Leu Thr Gly Gly  Ser Leu Glu Glu Leu  Arg Arg Val 
    1700                 1705                 1710             


Leu Glu  Gln Leu Ile Val Ala  His Phe Pro Met Gln  Ser Arg Glu 
    1715                 1720                 1725             


Phe Pro  Pro Gly Thr Pro Arg  Phe Asn Asn Tyr Val  Asp Cys Met 
    1730                 1735                 1740             


Lys Lys  Phe Leu Asp Ala Leu  Glu Leu Ser Gln Ser  Pro Met Leu 
    1745                 1750                 1755             


Leu Glu  Leu Met Thr Glu Val  Leu Cys Arg Glu Gln  Gln His Val 
    1760                 1765                 1770             


Met Glu  Glu Leu Phe Gln Ser  Ser Phe Arg Arg Ile  Ala Arg Arg 
    1775                 1780                 1785             


Gly Ser  Cys Val Thr Gln Val  Gly Leu Leu Glu Ser  Val Tyr Glu 
    1790                 1795                 1800             


Met Phe  Arg Lys Asp Asp Pro  Arg Leu Ser Phe Thr  Arg Gln Ser 
    1805                 1810                 1815             


Phe Val  Asp Arg Ser Leu Leu  Thr Leu Leu Trp His  Cys Ser Leu 
    1820                 1825                 1830             


Asp Ala  Leu Arg Glu Phe Phe  Ser Thr Ile Val Val  Asp Ala Ile 
    1835                 1840                 1845             


Asp Val  Leu Lys Ser Arg Phe  Thr Lys Leu Asn Glu  Ser Thr Phe 
    1850                 1855                 1860             


Asp Thr  Gln Ile Thr Lys Lys  Met Gly Tyr Tyr Lys  Ile Leu Asp 
    1865                 1870                 1875             


Val Met  Tyr Ser Arg Leu Pro  Lys Asp Asp Val His  Ala Lys Glu 
    1880                 1885                 1890             


Ser Lys  Ile Asn Gln Val Phe  His Gly Ser Cys Ile  Thr Glu Gly 
    1895                 1900                 1905             


Asn Glu  Leu Thr Lys Thr Leu  Ile Lys Leu Cys Tyr  Asp Ala Phe 
    1910                 1915                 1920             


Thr Glu  Asn Met Ala Gly Glu  Asn Gln Leu Leu Glu  Arg Arg Arg 
    1925                 1930                 1935             


Leu Tyr  His Cys Ala Ala Tyr  Asn Cys Ala Ile Ser  Val Ile Cys 
    1940                 1945                 1950             


Cys Val  Phe Asn Glu Leu Lys  Phe Tyr Gln Gly Phe  Leu Phe Ser 
    1955                 1960                 1965             


Glu Lys  Pro Glu Lys Asn Leu  Leu Ile Phe Glu Asn  Leu Ile Asp 
    1970                 1975                 1980             


Leu Lys  Arg Arg Tyr Asn Phe  Pro Val Glu Val Glu  Val Pro Met 
    1985                 1990                 1995             


Glu Arg  Lys Lys Lys Tyr Ile  Glu Ile Arg Lys Glu  Ala Arg Glu 
    2000                 2005                 2010             


Ala Ala  Asn Gly Asp Ser Asp  Gly Pro Ser Tyr Met  Ser Ser Leu 
    2015                 2020                 2025             


Ser Tyr  Leu Ala Asp Ser Thr  Leu Ser Glu Glu Met  Ser Gln Phe 
    2030                 2035                 2040             


Asp Phe  Ser Thr Gly Val Gln  Ser Tyr Ser Tyr Ser  Ser Gln Asp 
    2045                 2050                 2055             


Pro Arg  Pro Ala Thr Gly Arg  Phe Arg Arg Arg Glu  Gln Arg Asp 
    2060                 2065                 2070             


Pro Thr  Val His Asp Asp Val  Leu Glu Leu Glu Met  Asp Glu Leu 
    2075                 2080                 2085             


Asn Arg  His Glu Cys Met Ala  Pro Leu Thr Ala Leu  Val Lys His 
    2090                 2095                 2100             


Met His  Arg Ser Leu Gly Pro  Pro Gln Gly Glu Glu  Asp Ser Val 
    2105                 2110                 2115             


Pro Arg  Asp Leu Pro Ser Trp  Met Lys Phe Leu His  Gly Lys Leu 
    2120                 2125                 2130             


Gly Asn  Pro Ile Val Pro Leu  Asn Ile Arg Leu Phe  Leu Ala Lys 
    2135                 2140                 2145             


Leu Val  Ile Asn Thr Glu Glu  Val Phe Arg Pro Tyr  Ala Lys His 
    2150                 2155                 2160             


Trp Leu  Ser Pro Leu Leu Gln  Leu Ala Ala Ser Glu  Asn Asn Gly 
    2165                 2170                 2175             


Gly Glu  Gly Ile His Tyr Met  Val Val Glu Ile Val  Ala Thr Ile 
    2180                 2185                 2190             


Leu Ser  Trp Thr Gly Leu Ala  Thr Pro Thr Gly Val  Pro Lys Asp 
    2195                 2200                 2205             


Glu Val  Leu Ala Asn Arg Leu  Leu Asn Phe Leu Met  Lys His Val 
    2210                 2215                 2220             


Phe His  Pro Lys Arg Ala Val  Phe Arg His Asn Leu  Glu Ile Ile 
    2225                 2230                 2235             


Lys Thr  Leu Val Glu Cys Trp  Lys Asp Cys Leu Ser  Ile Pro Tyr 
    2240                 2245                 2250             


Arg Leu  Ile Phe Glu Lys Phe  Ser Gly Lys Asp Pro  Asn Ser Lys 
    2255                 2260                 2265             


Asp Asn  Ser Val Gly Ile Gln  Leu Leu Gly Ile Val  Met Ala Asn 
    2270                 2275                 2280             


Asp Leu  Pro Pro Tyr Asp Pro  Gln Cys Gly Ile Gln  Ser Ser Glu 
    2285                 2290                 2295             


Tyr Phe  Gln Ala Leu Val Asn  Asn Met Ser Phe Val  Arg Tyr Lys 
    2300                 2305                 2310             


Glu Val  Tyr Ala Ala Ala Ala  Glu Val Leu Gly Leu  Ile Leu Arg 
    2315                 2320                 2325             


Tyr Val  Met Glu Arg Lys Asn  Ile Leu Glu Glu Ser  Leu Cys Glu 
    2330                 2335                 2340             


Leu Val  Ala Lys Gln Leu Lys  Gln His Gln Asn Thr  Met Glu Asp 
    2345                 2350                 2355             


Lys Phe  Ile Val Cys Leu Asn  Lys Val Thr Lys Ser  Phe Pro Pro 
    2360                 2365                 2370             


Leu Ala  Asp Arg Phe Met Asn  Ala Val Phe Phe Leu  Leu Pro Lys 
    2375                 2380                 2385             


Phe His  Gly Val Leu Lys Thr  Leu Cys Leu Glu Val  Val Leu Cys 
    2390                 2395                 2400             


Arg Val  Glu Gly Met Thr Glu  Leu Tyr Phe Gln Leu  Lys Ser Lys 
    2405                 2410                 2415             


Asp Phe  Val Gln Val Met Arg  His Arg Asp Asp Glu  Arg Gln Lys 
    2420                 2425                 2430             


Val Cys  Leu Asp Ile Ile Tyr  Lys Met Met Pro Lys  Leu Lys Pro 
    2435                 2440                 2445             


Val Glu  Leu Arg Glu Leu Leu  Asn Pro Val Val Glu  Phe Val Ser 
    2450                 2455                 2460             


His Pro  Ser Thr Thr Cys Arg  Glu Gln Met Tyr Asn  Ile Leu Met 
    2465                 2470                 2475             


Trp Ile  His Asp Asn Tyr Arg  Asp Pro Glu Ser Glu  Thr Asp Asn 
    2480                 2485                 2490             


Asp Ser  Gln Glu Ile Phe Lys  Leu Ala Lys Asp Val  Leu Ile Gln 
    2495                 2500                 2505             


Gly Leu  Ile Asp Glu Asn Pro  Gly Leu Gln Leu Ile  Ile Arg Asn 
    2510                 2515                 2520             


Phe Trp  Ser His Glu Thr Arg  Leu Pro Ser Asn Thr  Leu Asp Arg 
    2525                 2530                 2535             


Leu Leu  Ala Leu Asn Ser Leu  Tyr Ser Pro Lys Ile  Glu Val His 
    2540                 2545                 2550             


Phe Leu  Ser Leu Ala Thr Asn  Phe Leu Leu Glu Met  Thr Ser Met 
    2555                 2560                 2565             


Ser Pro  Asp Tyr Pro Asn Pro  Met Phe Glu His Pro  Leu Ser Glu 
    2570                 2575                 2580             


Cys Glu  Phe Gln Glu Tyr Thr  Ile Asp Ser Asp Trp  Arg Phe Arg 
    2585                 2590                 2595             


Ser Thr  Val Leu Thr Pro Met  Phe Val Glu Thr Gln  Ala Ser Gln 
    2600                 2605                 2610             


Gly Thr  Leu Gln Thr Arg Thr  Gln Glu Gly Ser Leu  Ser Ala Arg 
    2615                 2620                 2625             


Trp Pro  Val Ala Gly Gln Ile  Arg Ala Thr Gln Gln  Gln His Asp 
    2630                 2635                 2640             


Phe Thr  Leu Thr Gln Thr Ala  Asp Gly Arg Ser Ser  Phe Asp Trp 
    2645                 2650                 2655             


Leu Thr  Gly Ser Ser Thr Asp  Pro Leu Val Asp His  Thr Ser Pro 
    2660                 2665                 2670             


Ser Ser  Asp Ser Leu Leu Phe  Ala His Lys Arg Ser  Glu Arg Leu 
    2675                 2680                 2685             


Gln Arg  Ala Pro Leu Lys Ser  Val Gly Pro Asp Phe  Gly Lys Lys 
    2690                 2695                 2700             


Arg Leu  Gly Leu Pro Gly Asp  Glu Val Asp Asn Lys  Val Lys Gly 
    2705                 2710                 2715             


Ala Ala  Gly Arg Thr Asp Leu  Leu Arg Leu Arg Arg  Arg Phe Met 
    2720                 2725                 2730             


Arg Asp  Gln Glu Lys Leu Ser  Leu Met Tyr Ala Arg  Lys Gly Val 
    2735                 2740                 2745             


Ala Glu  Gln Lys Arg Glu Lys  Glu Ile Lys Ser Glu  Leu Lys Met 
    2750                 2755                 2760             


Lys Gln  Asp Ala Gln Val Val  Leu Tyr Arg Ser Tyr  Arg His Gly 
    2765                 2770                 2775             


Asp Leu  Pro Asp Ile Gln Ile  Lys His Ser Ser Leu  Ile Thr Pro 
    2780                 2785                 2790             


Leu Gln  Ala Val Ala Gln Arg  Asp Pro Ile Ile Ala  Lys Gln Leu 
    2795                 2800                 2805             


Phe Ser  Ser Leu Phe Ser Gly  Ile Leu Lys Glu Met  Asp Lys Phe 
    2810                 2815                 2820             


Lys Thr  Leu Ser Glu Lys Asn  Asn Ile Thr Gln Lys  Leu Leu Gln 
    2825                 2830                 2835             


Asp Phe  Asn Arg Phe Leu Asn  Thr Thr Phe Ser Phe  Phe Pro Pro 
    2840                 2845                 2850             


Phe Val  Ser Cys Ile Gln Asp  Ile Ser Cys Gln His  Ala Ala Leu 
    2855                 2860                 2865             


Leu Ser  Leu Asp Pro Ala Ala  Val Ser Ala Gly Cys  Leu Ala Ser 
    2870                 2875                 2880             


Leu Gln  Gln Pro Val Gly Ile  Arg Leu Leu Glu Glu  Ala Leu Leu 
    2885                 2890                 2895             


Arg Leu  Leu Pro Ala Glu Leu  Pro Ala Lys Arg Val  Arg Gly Lys 
    2900                 2905                 2910             


Ala Arg  Leu Pro Pro Asp Val  Leu Arg Trp Val Glu  Leu Ala Lys 
    2915                 2920                 2925             


Leu Tyr  Arg Ser Ile Gly Glu  Tyr Asp Val Leu Arg  Gly Ile Phe 
    2930                 2935                 2940             


Thr Ser  Glu Ile Gly Thr Lys  Gln Ile Thr Gln Ser  Ala Leu Leu 
    2945                 2950                 2955             


Ala Glu  Ala Arg Ser Asp Tyr  Ser Glu Ala Ala Lys  Gln Tyr Asp 
    2960                 2965                 2970             


Glu Ala  Leu Asn Lys Gln Asp  Trp Val Asp Gly Glu  Pro Thr Glu 
    2975                 2980                 2985             


Ala Glu  Lys Asp Phe Trp Glu  Leu Ala Ser Leu Asp  Cys Tyr Asn 
    2990                 2995                 3000             


His Leu  Ala Glu Trp Lys Ser  Leu Glu Tyr Cys Ser  Thr Ala Ser 
    3005                 3010                 3015             


Ile Asp  Ser Glu Asn Pro Pro  Asp Leu Asn Lys Ile  Trp Ser Glu 
    3020                 3025                 3030             


Pro Phe  Tyr Gln Glu Thr Tyr  Leu Pro Tyr Met Ile  Arg Ser Lys 
    3035                 3040                 3045             


Leu Lys  Leu Leu Leu Gln Gly  Glu Ala Asp Gln Ser  Leu Leu Thr 
    3050                 3055                 3060             


Phe Ile  Asp Lys Ala Met His  Gly Glu Leu Gln Lys  Ala Ile Leu 
    3065                 3070                 3075             


Glu Leu  His Tyr Ser Gln Glu  Leu Ser Leu Leu Tyr  Leu Leu Gln 
    3080                 3085                 3090             


Asp Asp  Val Asp Arg Ala Lys  Tyr Tyr Ile Gln Asn  Gly Ile Gln 
    3095                 3100                 3105             


Ser Phe  Met Gln Asn Tyr Ser  Ser Ile Asp Val Leu  Leu His Gln 
    3110                 3115                 3120             


Ser Arg  Leu Thr Lys Leu Gln  Ser Val Gln Ala Leu  Thr Glu Ile 
    3125                 3130                 3135             


Gln Glu  Phe Ile Ser Phe Ile  Ser Lys Gln Gly Asn  Leu Ser Ser 
    3140                 3145                 3150             


Gln Val  Pro Leu Lys Arg Leu  Leu Asn Thr Trp Thr  Asn Arg Tyr 
    3155                 3160                 3165             


Pro Asp  Ala Lys Met Asp Pro  Met Asn Ile Trp Asp  Asp Ile Ile 
    3170                 3175                 3180             


Thr Asn  Arg Cys Phe Phe Leu  Ser Lys Ile Glu Glu  Lys Leu Thr 
    3185                 3190                 3195             


Pro Leu  Pro Glu Asp Asn Ser  Met Asn Val Asp Gln  Asp Gly Asp 
    3200                 3205                 3210             


Pro Ser  Asp Arg Met Glu Val  Gln Glu Gln Glu Glu  Asp Ile Ser 
    3215                 3220                 3225             


Ser Leu  Ile Arg Ser Cys Lys  Phe Ser Met Lys Met  Lys Met Ile 
    3230                 3235                 3240             


Asp Ser  Ala Arg Lys Gln Asn  Asn Phe Ser Leu Ala  Met Lys Leu 
    3245                 3250                 3255             


Leu Lys  Glu Leu His Lys Glu  Ser Lys Thr Arg Asp  Asp Trp Leu 
    3260                 3265                 3270             


Val Ser  Trp Val Gln Ser Tyr  Cys Arg Leu Ser His  Cys Arg Ser 
    3275                 3280                 3285             


Arg Ser  Gln Gly Cys Ser Glu  Gln Val Leu Thr Val  Leu Lys Thr 
    3290                 3295                 3300             


Val Ser  Leu Leu Asp Glu Asn  Asn Val Ser Ser Tyr  Leu Ser Lys 
    3305                 3310                 3315             


Asn Ile  Leu Ala Phe Arg Asp  Gln Asn Ile Leu Leu  Gly Thr Thr 
    3320                 3325                 3330             


Tyr Arg  Ile Ile Ala Asn Ala  Leu Ser Ser Glu Pro  Ala Cys Leu 
    3335                 3340                 3345             


Ala Glu  Ile Glu Glu Asp Lys  Ala Arg Arg Ile Leu  Glu Leu Ser 
    3350                 3355                 3360             


Gly Ser  Ser Ser Glu Asp Ser  Glu Lys Val Ile Ala  Gly Leu Tyr 
    3365                 3370                 3375             


Gln Arg  Ala Phe Gln His Leu  Ser Glu Ala Val Gln  Ala Ala Glu 
    3380                 3385                 3390             


Glu Glu  Ala Gln Pro Pro Ser  Trp Ser Cys Gly Pro  Ala Ala Gly 
    3395                 3400                 3405             


Val Ile  Asp Ala Tyr Met Thr  Leu Ala Asp Phe Cys  Asp Gln Gln 
    3410                 3415                 3420             


Leu Arg  Lys Glu Glu Glu Asn  Ala Ser Val Ile Asp  Ser Ala Glu 
    3425                 3430                 3435             


Leu Gln  Ala Tyr Pro Ala Leu  Val Val Glu Lys Met  Leu Lys Ala 
    3440                 3445                 3450             


Leu Lys  Leu Asn Ser Asn Glu  Ala Arg Leu Lys Phe  Pro Arg Leu 
    3455                 3460                 3465             


Leu Gln  Ile Ile Glu Arg Tyr  Pro Glu Glu Thr Leu  Ser Leu Met 
    3470                 3475                 3480             


Thr Lys  Glu Ile Ser Ser Val  Pro Cys Trp Gln Phe  Ile Ser Trp 
    3485                 3490                 3495             


Ile Ser  His Met Val Ala Leu  Leu Asp Lys Asp Gln  Ala Val Ala 
    3500                 3505                 3510             


Val Gln  His Ser Val Glu Glu  Ile Thr Asp Asn Tyr  Pro Gln Ala 
    3515                 3520                 3525             


Ile Val  Tyr Pro Phe Ile Ile  Ser Ser Glu Ser Tyr  Ser Phe Lys 
    3530                 3535                 3540             


Asp Thr  Ser Thr Gly His Lys  Asn Lys Glu Phe Val  Ala Arg Ile 
    3545                 3550                 3555             


Lys Ser  Lys Leu Asp Gln Gly  Gly Val Ile Gln Asp  Phe Ile Asn 
    3560                 3565                 3570             


Ala Leu  Asp Gln Leu Ser Asn  Pro Glu Leu Leu Phe  Lys Asp Trp 
    3575                 3580                 3585             


Ser Asn  Asp Val Arg Ala Glu  Leu Ala Lys Thr Pro  Val Asn Lys 
    3590                 3595                 3600             


Lys Asn  Ile Glu Lys Met Tyr  Glu Arg Met Tyr Ala  Ala Leu Gly 
    3605                 3610                 3615             


Asp Pro  Lys Ala Pro Gly Leu  Gly Ala Phe Arg Arg  Lys Phe Ile 
    3620                 3625                 3630             


Gln Thr  Phe Gly Lys Glu Phe  Asp Lys His Phe Gly  Lys Gly Gly 
    3635                 3640                 3645             


Ser Lys  Leu Leu Arg Met Lys  Leu Ser Asp Phe Asn  Asp Ile Thr 
    3650                 3655                 3660             


Asn Met  Leu Leu Leu Lys Met  Asn Lys Asp Ser Lys  Pro Pro Gly 
    3665                 3670                 3675             


Asn Leu  Lys Glu Cys Ser Pro  Trp Met Ser Asp Phe  Lys Val Glu 
    3680                 3685                 3690             


Phe Leu  Arg Asn Glu Leu Glu  Ile Pro Gly Gln Tyr  Asp Gly Arg 
    3695                 3700                 3705             


Gly Lys  Pro Leu Pro Glu Tyr  His Val Arg Ile Ala  Gly Phe Asp 
    3710                 3715                 3720             


Glu Arg  Val Thr Val Met Ala  Ser Leu Arg Arg Pro  Lys Arg Ile 
    3725                 3730                 3735             


Ile Ile  Arg Gly His Asp Glu  Arg Glu His Pro Phe  Leu Val Lys 
    3740                 3745                 3750             


Gly Gly  Glu Asp Leu Arg Gln  Asp Gln Arg Val Glu  Gln Leu Phe 
    3755                 3760                 3765             


Gln Val  Met Asn Gly Ile Leu  Ala Gln Asp Ser Ala  Cys Ser Gln 
    3770                 3775                 3780             


Arg Ala  Leu Gln Leu Arg Thr  Tyr Ser Val Val Pro  Met Thr Ser 
    3785                 3790                 3795             


Ser Asp  Pro Arg Ala Pro Pro  Cys Glu Tyr Lys Asp  Trp Leu Thr 
    3800                 3805                 3810             


Lys Met  Ser Gly Lys His Asp  Val Gly Ala Tyr Met  Leu Met Tyr 
    3815                 3820                 3825             


Lys Gly  Ala Asn Arg Thr Glu  Thr Val Thr Ser Phe  Arg Lys Arg 
    3830                 3835                 3840             


Glu Ser  Lys Val Pro Ala Asp  Leu Leu Lys Arg Ala  Phe Val Arg 
    3845                 3850                 3855             


Met Ser  Thr Ser Pro Glu Ala  Phe Leu Ala Leu Arg  Ser His Phe 
    3860                 3865                 3870             


Ala Ser  Ser His Ala Leu Ile  Cys Ile Ser His Trp  Ile Leu Gly 
    3875                 3880                 3885             


Ile Gly  Asp Arg His Leu Asn  Asn Phe Met Val Ala  Met Glu Thr 
    3890                 3895                 3900             


Gly Gly  Val Ile Gly Ile Asp  Phe Gly His Ala Phe  Gly Ser Ala 
    3905                 3910                 3915             


Thr Gln  Phe Leu Pro Val Pro  Glu Leu Met Pro Phe  Arg Leu Thr 
    3920                 3925                 3930             


Arg Gln  Phe Ile Asn Leu Met  Leu Pro Met Lys Glu  Thr Gly Leu 
    3935                 3940                 3945             


Met Tyr  Ser Ile Met Val His  Ala Leu Arg Ala Phe  Arg Ser Asp 
    3950                 3955                 3960             


Pro Gly  Leu Leu Thr Asn Thr  Met Asp Val Phe Val  Lys Glu Pro 
    3965                 3970                 3975             


Ser Phe  Asp Trp Lys Asn Phe  Glu Gln Lys Met Leu  Lys Lys Gly 
    3980                 3985                 3990             


Gly Ser  Trp Ile Gln Glu Ile  Asn Val Ala Glu Lys  Asn Trp Tyr 
    3995                 4000                 4005             


Pro Arg  Gln Lys Ile Cys Tyr  Ala Lys Arg Lys Leu  Ala Gly Ala 
    4010                 4015                 4020             


Asn Pro  Ala Val Ile Thr Cys  Asp Glu Leu Leu Leu  Gly His Glu 
    4025                 4030                 4035             


Lys Ala  Pro Ala Phe Arg Asp  Tyr Val Ala Val Ala  Arg Gly Ser 
    4040                 4045                 4050             


Lys Asp  His Asn Ile Arg Ala  Gln Glu Pro Glu Ser  Gly Leu Ser 
    4055                 4060                 4065             


Glu Glu  Thr Gln Val Lys Cys  Leu Met Asp Gln Ala  Thr Asp Pro 
    4070                 4075                 4080             


Asn Ile  Leu Gly Arg Thr Trp  Glu Gly Trp Glu Pro  Trp Met 
    4085                 4090                 4095         


<210> 449
<211> 1308
<212> DNA
<213> Homo sapiens

<400> 449
gtcagccgct gtccccttag ccgcgatgcc gctggagaac ctggaggagg agggtctgcc       60

caagaacccc gacttgcgta tcgcgcagct gcgcttcctg ctcagcctgc ccgagcaccg      120

cggagacgct gccgtgcgcg acgagctgat ggcggccgtc cgcgataaca acatggctcc      180

ttactatgaa gccttgtgca aatccctcga ctggcagata gacgtggacc tactcaataa      240

aatgaagaag gcaaatgaag atgagttgaa gcgtttggat gaggagctgg aagatgcaga      300

gaagaatcta ggagagagcg aaattcgcga tgcaatgatg gcaaaggccg agtacctctg      360

ccggataggt gacaaagagg gagctctgac agcctttcgc aagacatatg acaaaactgt      420

ggccctgggt caccgattgg atattgtatt ctatctcctt aggattggct tattttatat      480

ggataatgat ctcatcacac gaaacacaga aaaggccaaa agcttaatag aagaaggagg      540

agactgggac aggagaaacc gcctaaaagt gtatcagggt ctttattgtg tggctattcg      600

tgatttcaaa caggcagctg aactcttcct tgacactgtt tcaacattta catcctatga      660

actcatggat tataaaacat ttgtgactta tactgtctat gtcagtatga ttgccttaga      720

aagaccagat ctcagggaaa aggtcattaa aggagcagag attcttgaag tgttgcacag      780

tcttccagca gttcggcagt atctgttttc actctatgaa tgccgttact ctgttttctt      840

ccaatcatta gcggttgtgg aacaggaaat gaaaaaggac tggctttttg cccctcatta      900

tcgatactat gtaagagaaa tgagaattca tgcatacagt cagctgctgg aatcatatag      960

gtcattaacc cttggctata tggcagaagc gtttggtgtt ggtgtggaat tcattgatca     1020

ggaactgtcc aggtttattg ctgccgggag actacactgc aaaatagata aagtgaatga     1080

aatagtagaa accaacagac ctgatagcaa gaactggcag taccaagaaa ctatcaagaa     1140

aggagatctg ctactaaaca gagttcaaaa actttccaga gtaattaata tgtaaagcca     1200

tgtaactaac aaaggatttg ctttagagat aattatttgg aatttttata gcttacttca     1260

caatgtgccc aggtcagctg tataaaataa atactgcatt gttgtttc                  1308


<210> 450
<211> 389
<212> PRT
<213> Homo sapiens

<400> 450
Met Pro Leu Glu Asn Leu Glu Glu Glu Gly Leu Pro Lys Asn Pro Asp 
1               5                   10                  15      


Leu Arg Ile Ala Gln Leu Arg Phe Leu Leu Ser Leu Pro Glu His Arg 
            20                  25                  30          


Gly Asp Ala Ala Val Arg Asp Glu Leu Met Ala Ala Val Arg Asp Asn 
        35                  40                  45              


Asn Met Ala Pro Tyr Tyr Glu Ala Leu Cys Lys Ser Leu Asp Trp Gln 
    50                  55                  60                  


Ile Asp Val Asp Leu Leu Asn Lys Met Lys Lys Ala Asn Glu Asp Glu 
65                  70                  75                  80  


Leu Lys Arg Leu Asp Glu Glu Leu Glu Asp Ala Glu Lys Asn Leu Gly 
                85                  90                  95      


Glu Ser Glu Ile Arg Asp Ala Met Met Ala Lys Ala Glu Tyr Leu Cys 
            100                 105                 110         


Arg Ile Gly Asp Lys Glu Gly Ala Leu Thr Ala Phe Arg Lys Thr Tyr 
        115                 120                 125             


Asp Lys Thr Val Ala Leu Gly His Arg Leu Asp Ile Val Phe Tyr Leu 
    130                 135                 140                 


Leu Arg Ile Gly Leu Phe Tyr Met Asp Asn Asp Leu Ile Thr Arg Asn 
145                 150                 155                 160 


Thr Glu Lys Ala Lys Ser Leu Ile Glu Glu Gly Gly Asp Trp Asp Arg 
                165                 170                 175     


Arg Asn Arg Leu Lys Val Tyr Gln Gly Leu Tyr Cys Val Ala Ile Arg 
            180                 185                 190         


Asp Phe Lys Gln Ala Ala Glu Leu Phe Leu Asp Thr Val Ser Thr Phe 
        195                 200                 205             


Thr Ser Tyr Glu Leu Met Asp Tyr Lys Thr Phe Val Thr Tyr Thr Val 
    210                 215                 220                 


Tyr Val Ser Met Ile Ala Leu Glu Arg Pro Asp Leu Arg Glu Lys Val 
225                 230                 235                 240 


Ile Lys Gly Ala Glu Ile Leu Glu Val Leu His Ser Leu Pro Ala Val 
                245                 250                 255     


Arg Gln Tyr Leu Phe Ser Leu Tyr Glu Cys Arg Tyr Ser Val Phe Phe 
            260                 265                 270         


Gln Ser Leu Ala Val Val Glu Gln Glu Met Lys Lys Asp Trp Leu Phe 
        275                 280                 285             


Ala Pro His Tyr Arg Tyr Tyr Val Arg Glu Met Arg Ile His Ala Tyr 
    290                 295                 300                 


Ser Gln Leu Leu Glu Ser Tyr Arg Ser Leu Thr Leu Gly Tyr Met Ala 
305                 310                 315                 320 


Glu Ala Phe Gly Val Gly Val Glu Phe Ile Asp Gln Glu Leu Ser Arg 
                325                 330                 335     


Phe Ile Ala Ala Gly Arg Leu His Cys Lys Ile Asp Lys Val Asn Glu 
            340                 345                 350         


Ile Val Glu Thr Asn Arg Pro Asp Ser Lys Asn Trp Gln Tyr Gln Glu 
        355                 360                 365             


Thr Ile Lys Lys Gly Asp Leu Leu Leu Asn Arg Val Gln Lys Leu Ser 
    370                 375                 380                 


Arg Val Ile Asn Met 
385                 


<210> 451
<211> 3879
<212> DNA
<213> Homo sapiens

<400> 451
atcagacgcg cagaggaggc ggggccgcgg ctggtttcct gccggggggc ggctctgggc       60

cgccgagtcc cctcctcccg cccctgagga ggaggagccg ccgccacccg ccgcgcccga      120

cacccgggag gccccgccag cccgcgggag aggcccagcg ggagtcgcgg aacagcaggc      180

ccgagcccac cgcgccgggc cccggacgcc gcgcggaaaa gatgaattta caaccaattt      240

tctggattgg actgatcagt tcagtttgct gtgtgtttgc tcaaacagat gaaaatagat      300

gtttaaaagc aaatgccaaa tcatgtggag aatgtataca agcagggcca aattgtgggt      360

ggtgcacaaa ttcaacattt ttacaggaag gaatgcctac ttctgcacga tgtgatgatt      420

tagaagcctt aaaaaagaag ggttgccctc cagatgacat agaaaatccc agaggctcca      480

aagatataaa gaaaaataaa aatgtaacca accgtagcaa aggaacagca gagaagctca      540

agccagagga tattactcag atccaaccac agcagttggt tttgcgatta agatcagggg      600

agccacagac atttacatta aaattcaaga gagctgaaga ctatcccatt gacctctact      660

accttatgga cctgtcttac tcaatgaaag acgatttgga gaatgtaaaa agtcttggaa      720

cagatctgat gaatgaaatg aggaggatta cttcggactt cagaattgga tttggctcat      780

ttgtggaaaa gactgtgatg ccttacatta gcacaacacc agctaagctc aggaaccctt      840

gcacaagtga acagaactgc accagcccat ttagctacaa aaatgtgctc agtcttacta      900

ataaaggaga agtatttaat gaacttgttg gaaaacagcg catatctgga aatttggatt      960

ctccagaagg tggtttcgat gccatcatgc aagttgcagt ttgtggatca ctgattggct     1020

ggaggaatgt tacacggctg ctggtgtttt ccacagatgc cgggtttcac tttgctggag     1080

atgggaaact tggtggcatt gttttaccaa atgatggaca atgtcacctg gaaaataata     1140

tgtacacaat gagccattat tatgattatc cttctattgc tcaccttgtc cagaaactga     1200

gtgaaaataa tattcagaca atttttgcag ttactgaaga atttcagcct gtttacaagg     1260

agctgaaaaa cttgatccct aagtcagcag taggaacatt atctgcaaat tctagcaatg     1320

taattcagtt gatcattgat gcatacaatt ccctttcctc agaagtcatt ttggaaaacg     1380

gcaaattgtc agaaggcgta acaataagtt acaaatctta ctgcaagaac ggggtgaatg     1440

gaacagggga aaatggaaga aaatgttcca atatttccat tggagatgag gttcaatttg     1500

aaattagcat aacttcaaat aagtgtccaa aaaaggattc tgacagcttt aaaattaggc     1560

ctctgggctt tacggaggaa gtagaggtta ttcttcagta catctgtgaa tgtgaatgcc     1620

aaagcgaagg catccctgaa agtcccaagt gtcatgaagg aaatgggaca tttgagtgtg     1680

gcgcgtgcag gtgcaatgaa gggcgtgttg gtagacattg tgaatgcagc acagatgaag     1740

ttaacagtga agacatggat gcttactgca ggaaagaaaa cagttcagaa atctgcagta     1800

acaatggaga gtgcgtctgc ggacagtgtg tttgtaggaa gagggataat acaaatgaaa     1860

tttattctgg caaattctgc gagtgtgata atttcaactg tgatagatcc aatggcttaa     1920

tttgtggagg aaatggtgtt tgcaagtgtc gtgtgtgtga gtgcaacccc aactacactg     1980

gcagtgcatg tgactgttct ttggatacta gtacttgtga agccagcaac ggacagatct     2040

gcaatggccg gggcatctgc gagtgtggtg tctgtaagtg tacagatccg aagtttcaag     2100

ggcaaacgtg tgagatgtgt cagacctgcc ttggtgtctg tgctgagcat aaagaatgtg     2160

ttcagtgcag agccttcaat aaaggagaaa agaaagacac atgcacacag gaatgttcct     2220

attttaacat taccaaggta gaaagtcggg acaaattacc ccagccggtc caacctgatc     2280

ctgtgtccca ttgtaaggag aaggatgttg acgactgttg gttctatttt acgtattcag     2340

tgaatgggaa caacgaggtc atggttcatg ttgtggagaa tccagagtgt cccactggtc     2400

cagacatcat tccaattgta gctggtgtgg ttgctggaat tgttcttatt ggccttgcat     2460

tactgctgat atggaagctt ttaatgataa ttcatgacag aagggagttt gctaaatttg     2520

aaaaggagaa aatgaatgcc aaatgggaca cgggtgaaaa tcctatttat aagagtgccg     2580

taacaactgt ggtcaatccg aagtatgagg gaaaatgagt actgcccgtg caaatcccac     2640

aacactgaat gcaaagtagc aatttccata gtcacagtta ggtagcttta gggcaatatt     2700

gccatggttt tactcatgtg caggttttga aaatgtacaa tatgtataat ttttaaaatg     2760

ttttattatt ttgaaaataa tgttgtaatt catgccaggg actgacaaaa gacttgagac     2820

aggatggtta ctcttgtcag ctaaggtcac attgtgcctt tttgaccttt tcttcctgga     2880

ctattgaaat caagcttatt ggattaagtg atatttctat agcgattgaa agggcaatag     2940

ttaaagtaat gagcatgatg agagtttctg ttaatcatgt attaaaactg atttttagct     3000

ttacaaatat gtcagtttgc agttatgcag aatccaaagt aaatgtcctg ctagctagtt     3060

aaggattgtt ttaaatctgt tattttgcta tttgcctgtt agacatgact gatgacatat     3120

ctgaaagaca agtatgttga gagttgctgg tgtaaaatac gtttgaaata gttgatctac     3180

aaaggccatg ggaaaaattc agagagttag gaaggaaaaa ccaatagctt taaaacctgt     3240

gtgccatttt aagagttact taatgtttgg taacttttat gccttcactt tacaaattca     3300

agccttagat aaaagaaccg agcaattttc tgctaaaaag tccttgattt agcactattt     3360

acatacaggc catactttac aaagtatttg ctgaatgggg accttttgag ttgaatttat     3420

tttattattt ttattttgtt taatgtctgg tgctttctgt cacctcttct aatcttttaa     3480

tgtatttgtt tgcaattttg gggtaagact ttttttatga gtactttttc tttgaagttt     3540

tagcggtcaa tttgcctttt taatgaacat gtgaagttat actgtggcta tgcaacagct     3600

ctcacctacg cgagtcttac tttgagttag tgccataaca gaccactgta tgtttacttc     3660

tcaccatttg agttgcccat cttgtttcac actagtcaca ttcttgtttt aagtgccttt     3720

agttttaaca gttcactttt tacagtgcta tttactgaag ttatttatta aatatgccta     3780

aaatacttaa atcggatgtc ttgactctga tgtattttat caggttgtgt gcatgaaatt     3840

tttatagatt aaagaagttg aggaaaagca aaaaaaaaa                            3879


<210> 452
<211> 798
<212> PRT
<213> Homo sapiens

<400> 452
Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210> 453
<211> 7778
<212> DNA
<213> Homo sapiens

<400> 453
agcagtgcta aaggagcccg gcggaggcag cggtgggttt gggactgagg cgctggatct       60

gtggtcgcgg ctggggacgt gcgcccgcgc caccatcttc ggctgaagag gcaattgctt      120

ttggatcgtt ccatttacaa tggcgcagag aactggactc gaggatccag agaggtatct      180

ctttgtggac agggctgtca tctacaaccc tgccactcaa gctgattgga cagctaaaaa      240

gctagtgtgg attccatcag aacgccatgg ttttgaggca gctagtatca aagaagaacg      300

gggagatgaa gttatggtgg agttggcaga gaatggaaag aaagcaatgg tcaacaaaga      360

tgatattcag aagatgaacc cacctaagtt ttccaaggtg gaggatatgg cagaattgac      420

atgcttgaat gaagcttccg ttttacataa tctgaaggat cgctactatt caggactaat      480

ctatacttat tctggactct tctgtgtagt tataaaccct tacaagaatc ttccaattta      540

ctctgagaat attattgaaa tgtacagagg gaagaagcgt catgagatgc ctccacacat      600

ctatgctata tctgaatctg cttacagatg catgcttcaa gatcgtgagg accagtcaat      660

tctttgcacg ggtgagtcag gtgctgggaa gacagaaaat acaaagaaag ttattcagta      720

ccttgcccat gttgcttctt cacataaagg aagaaaggac cataatattc ctcaggaatc      780

gcctaaacca gtgaaacacc agggggaact tgaacggcag cttttgcaag caaatccaat      840

tctggaatca tttggaaatg cgaagactgt gaaaaatgat aactcatctc gttttggcaa      900

atttattcgg atcaactttg atgtaactgg ctatatcgtt ggggccaaca ttgaaacata      960

ccttctggaa aagtctcgtg ctgttcgtca agcaaaagat gaacgtactt ttcatatctt     1020

ttaccagttg ttatctggag caggagaaca cctaaagtct gatttgcttc ttgaaggatt     1080

taataactac aggtttctct ccaatggcta tattcctatt ccgggacagc aagacaaaga     1140

taatttccag gagaccatgg aagcaatgca cataatgggc ttctcccatg aagagattct     1200

gtcaatgctt aaagtagtat cttcagtgct acagtttgga aatatttctt tcaaaaagga     1260

gagaaatact gatcaagctt ccatgccaga aaatacagtt gcgcagaagc tctgccatct     1320

tcttgggatg aatgtgatgg agtttactcg ggccatcctg actccccgga tcaaggtcgg     1380

ccgagactat gtgcaaaaag cccagaccaa agaacaggca gattttgcag tagaagcatt     1440

ggcaaaagct acctatgagc ggctctttcg ctggctcgtt catcgcatca ataaagctct     1500

ggataggacc aaacgtcagg gagcatcttt cattggaatc ctggatattg ctggatttga     1560

aatttttgag ctgaactcct ttgaacaact ttgcatcaac tacaccaatg agaagctgca     1620

gcagctgttc aaccacacca tgtttatcct agaacaagag gaataccagc gcgaaggcat     1680

cgagtggaac ttcatcgatt tcgggctgga tctgcagcca tgcatcgacc taatagagag     1740

acctgcgaac cctcctggtg tactggccct tttggatgaa gaatgctggt tccctaaagc     1800

cacagataaa acctttgttg aaaaactggt tcaagagcaa ggttcccact ccaagtttca     1860

gaaacctcga caattaaaag acaaagctga tttttgcatt atacattatg cagggaaggt     1920

ggactataag gcagatgagt ggctgatgaa gaatatggac cccctgaatg acaacgtggc     1980

cacccttttg caccagtcat cagacagatt tgtggcagag ctttggaaag atgagattca     2040

gaatattcag agagcttctt tctatgacag tgtttctggt cttcatgagc caccagtgga     2100

ccgtatcgtg ggtctggatc aagtcactgg tatgactgag acagcttttg gctccgcata     2160

taaaaccaag aagggcatgt ttcgtaccgt tgggcaactc tacaaagaat ctctcaccaa     2220

gctgatggca actctccgaa acaccaaccc taactttgtt cgttgtatca ttccaaatca     2280

cgagaagagg gctggaaaat tggatccaca cctagtccta gatcagcttc gctgtaatgg     2340

tgtcctggaa gggatccgaa tctgtcgcca gggcttccct aaccgaatag ttttccagga     2400

attcagacag agatatgaga tcctaactcc aaatgctatt cctaaaggtt ttatggatgg     2460

taaacaggcc tgtgaacgaa tgatccgggc tttagaattg gacccaaact tgtacagaat     2520

tggacagagc aagatatttt tcagagctgg agttctggca cacttagagg aagaaagaga     2580

tttaaaaatc accgatatca ttatcttctt ccaggccgtt tgcagaggtt acctggccag     2640

aaaggccttt gccaagaagc agcagcaact aagtgcctta aaggtcttgc agcggaactg     2700

tgccgcgtac ctgaaattac ggcactggca gtggtggcga gtcttcacaa aggtgaagcc     2760

gcttctacaa gtgactcgcc aggaggaaga acttcaggcc aaagatgaag agctgttgaa     2820

ggtgaaggag aagcagacga aggtggaagg agagctggag gagatggagc ggaagcacca     2880

gcagctttta gaagagaaga atatccttgc agaacaacta caagcagaga ctgagctctt     2940

tgctgaagca gaagagatga gggcaagact tgctgctaaa aagcaggaat tagaagagat     3000

tctacatgac ttggagtcta gggttgaaga agaagaagaa agaaaccaaa tcctccaaaa     3060

tgaaaagaaa aaaatgcaag cacatattca ggacctggaa gaacagctag acgaggagga     3120

aggggctcgg caaaagctgc agctggaaaa ggtgacagca gaggccaaga tcaagaagat     3180

ggaagaggag attctgcttc tcgaggacca aaattccaag ttcatcaaag aaaagaaact     3240

catggaagat cgcattgctg agtgttcctc tcagctggct gaagaggaag aaaaggcgaa     3300

aaacttggcc aaaatcagga ataagcaaga agtgatgatc tcagatttag aagaacgctt     3360

aaagaaggaa gaaaagactc gtcaggaact ggaaaaggcc aaaagaaaac tcgacgggga     3420

gacgaccgac ctgcaggacc agatcgcaga gctgcaggcg cagattgatg agctcaagct     3480

gcagctggcc aagaaggagg aggagctgca gggcgcactg gccagaggtg atgatgaaac     3540

actccataag aacaatgccc ttaaagttgt gcgagagcta caagcccaaa ttgctgaact     3600

tcaggaagac tttgaatccg agaaggcttc acggaacaag gccgaaaagc agaaaaggga     3660

cttgagtgag gaactggaag ctctgaaaac agagctggag gacacgctgg acaccacggc     3720

agcccagcag gaactacgta caaaacgtga acaagaagtg gcagagctga agaaagctct     3780

tgaggaggaa actaagaacc atgaagctca aatccaggac atgagacaaa gacacgcaac     3840

agccctggag gagctctcag agcagctgga acaggccaag cggttcaaag caaatctaga     3900

gaagaacaag cagggcctgg agacagataa caaggagctg gcgtgtgagg tgaaggtcct     3960

gcagcaggtc aaggctgagt ctgagcacaa gaggaagaag ctcgacgcgc aggtccagga     4020

gctccatgcc aaggtctctg aaggcgacag gctcagggtg gagctggcgg agaaagcaag     4080

taagctgcag aatgagctag ataatgtctc cacccttctg gaagaagcag agaagaaggg     4140

tattaaattt gctaaggatg cagctagtct tgagtctcaa ctacaggata cacaggagct     4200

tcttcaggag gagacacgcc agaaactaaa cctgagcagt cggatccggc agctggaaga     4260

ggagaagaac agtcttcagg agcagcagga ggaggaggag gaggccagga agaacctgga     4320

gaagcaagtg ctggccctgc agtcccagtt ggctgatacc aagaagaaag tagatgacga     4380

cctgggaaca attgaaagtc tggaagaagc caagaagaag cttctgaagg acgcggaggc     4440

cctgagccag cgcctggagg agaaggcact ggcgtatgac aaactggaga agaccaagaa     4500

ccgcctgcag caggagctgg acgacctcac ggtggacctg gaccaccagc gccaggtcgc     4560

ctccaacttg gagaagaagc agaagaagtt tgaccagctg ttagcagaag agaagagcat     4620

ctctgctcgc tatgccgaag agcgggaccg ggccgaagcc gaggccagag agaaagaaac     4680

caaagccctg tcactggccc gggccctcga ggaagccctg gaggccaagg aggagtttga     4740

gaggcagaac aagcagctcc gagcagacat ggaagacctc atgagctcca aagatgatgt     4800

gggaaaaaac gttcacgaac ttgaaaaatc caaacgggcc ctagagcagc aggtggagga     4860

aatgaggacc cagctggagg agctggaaga cgaactccag gccacggaag atgccaagct     4920

tcgtctggag gtcaacatgc aggccatgaa ggcgcagttc gagagagacc tgcaaaccag     4980

ggatgagcag aatgaagaga agaagcggct gctgatcaaa caggtgcggg agctcgaggc     5040

ggagctggag gatgagagga aacagcgggc gcttgctgta gcttcaaaga aaaagatgga     5100

gatagacctg aaggacctcg aagcccaaat cgaggctgcg aacaaagctc gggatgaggt     5160

gattaagcag ctccgcaagc tccaggctca gatgaaggat taccaacgtg aattagaaga     5220

agctcgtgca tccagagatg agatttttgc tcaatccaaa gagagtgaaa agaaattgaa     5280

gagtctggaa gcagaaatcc ttcaattgca ggaggaactt gcctcatctg agcgagcccg     5340

ccgacacgcc gagcaggaga gagatgagct ggcggacgag atcaccaaca gcgcctctgg     5400

caagtccgcg ctgctggatg agaagcggcg tctggaagct cggatcgcac agctggagga     5460

ggagctggaa gaggagcaga gcaacatgga gctgctcaac gaccgcttcc gcaagaccac     5520

tctacaggtg gacacactga acgccgagct agcagccgag cgcagcgccg cccagaagag     5580

tgacaatgca cgccagcaac tggagcggca gaacaaggag ctgaaggcca agctgcagga     5640

actcgagggt gctgtcaagt ctaagttcaa ggccaccatc tcagccctgg aggccaagat     5700

tgggcagctg gaggagcagc ttgagcagga agccaaggaa cgagcagccg ccaacaaatt     5760

agtccgtcgc actgagaaga agctgaaaga aatcttcatg caggttgagg atgagcgtcg     5820

acacgcggac cagtataaag agcagatgga gaaggccaac gctcggatga agcagcttaa     5880

acgccagctg gaggaagcag aagaagaagc gacgcgtgcc aacgcatctc ggcgtaaact     5940

ccagcgggaa ctggatgatg ccaccgaggc caacgagggc ctgagccgcg aggtcagcac     6000

cctgaagaac cggctgaggc ggggtggccc catcagcttc tcttccagcc gatctggccg     6060

gcgccagctg caccttgaag gagcttccct ggagctctcc gacgatgaca cagaaagtaa     6120

gaccagtgat gtcaacgaga cgcagccacc ccagtcagag taaagttgca ggaagccaga     6180

ggaggcaata cagtgggaca gttaggaatg cacccggggc ctcctgcaga tttcggaaat     6240

tggcaagcta cgggattcct tcctgaaaga tcaactgtgt cttaaggctc tccagcctat     6300

gcatactgta tcctgcttca gacttaggta caattgctcc cctttttata tatagacaca     6360

cacaggacac atatattaaa cagattgttt catcattgca tctattttcc atatagtcat     6420

caagagacca ttttataaaa catggtaaga ccctttttaa aacaaactcc aggcccttgg     6480

ttgcgggtcg ctgggttatt ggggcagcgc cgtggtcgtc actcagtcgc tctgcatgct     6540

ctctgtcata cagacaggta acctagttct gtgttcacgt ggcccccgac tcctcagcca     6600

catcaagtct cctagaccac tgtggactct aaactgcact tgtctctctc atttccttca     6660

aataatgatc aatgctattt cagtgagcaa actgtgaaag gggctttgga aagagtagga     6720

ggggtgggct ggatcggaag caacacccat ttggggttac catgtccatc ccccaagggg     6780

ggccctgccc ctcgagtcga tggtgtcccg catctactca tgtgaactgg ccttggcgag     6840

ggctggtctg tgcatagaag ggatagtggc cacactgcag ctgaggcccc aggtggcagc     6900

catggatcat gtagacttcc agatggtctc ccgaaccgcc tggctctgcc ggcgccctcc     6960

tcacgtcagg agcaagcagc cgtggacccc taagccgagc tggtggaagg cccctccccg     7020

tcgccagccg ggccctcatg ctgaccttgc aaattcagcc gctgctttga gcccaaaatg     7080

ggaatattgg ttttgtgtcc gaggcttgtt ccaagtttgt caatgaggtt tatggagcct     7140

ccagaacaga tgccatcttc ctgaatgttg acatgccagt gggtgtgact ccttcatttt     7200

tccttctccc ttccctttgg acagtgttac agtgaacact tagcatcctg tttttggttg     7260

gtagttaagc aaactgacat tacggaaagt gccttagaca ctacagtact aagacaatgt     7320

tgaatatatc attcgcctct ataacaattt aatgtattca gttttgactg tgcttcatat     7380

catgtacctc tctagtcaaa gtggtattac agacattcag tgacaatgaa tcagtgttaa     7440

ttctaaatcc ttgatcctct gcaatgtgct tgaaaacaca aaccttttgg gttaaaagct     7500

ttaacatcta ttaggaagaa tttgtcctgt gggtttggaa tcttggattt tcccccttta     7560

tgaactgtac tggctgttga ccaccagaca cctgaccgca aatatctttt cttgtattcc     7620

catatttcta gacaatgatt tttgtaagac aataaattta ttcattatag atatttgcgc     7680

ctgctctgtt tacttgaaga aaaaagcacc cgtggagaat aaagagacct caataaacaa     7740

gaataatcat gtgaacgtgg aaaaaaaaaa aaaaaaaa                             7778


<210> 454
<211> 2007
<212> PRT
<213> Homo sapiens

<400> 454
Met Ala Gln Arg Thr Gly Leu Glu Asp Pro Glu Arg Tyr Leu Phe Val 
1               5                   10                  15      


Asp Arg Ala Val Ile Tyr Asn Pro Ala Thr Gln Ala Asp Trp Thr Ala 
            20                  25                  30          


Lys Lys Leu Val Trp Ile Pro Ser Glu Arg His Gly Phe Glu Ala Ala 
        35                  40                  45              


Ser Ile Lys Glu Glu Arg Gly Asp Glu Val Met Val Glu Leu Ala Glu 
    50                  55                  60                  


Asn Gly Lys Lys Ala Met Val Asn Lys Asp Asp Ile Gln Lys Met Asn 
65                  70                  75                  80  


Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                85                  90                  95      


Asn Glu Ala Ser Val Leu His Asn Leu Lys Asp Arg Tyr Tyr Ser Gly 
            100                 105                 110         


Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Ile Asn Pro Tyr 
        115                 120                 125             


Lys Asn Leu Pro Ile Tyr Ser Glu Asn Ile Ile Glu Met Tyr Arg Gly 
    130                 135                 140                 


Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ser Glu Ser 
145                 150                 155                 160 


Ala Tyr Arg Cys Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys 
                165                 170                 175     


Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
            180                 185                 190         


Gln Tyr Leu Ala His Val Ala Ser Ser His Lys Gly Arg Lys Asp His 
        195                 200                 205             


Asn Ile Pro Gln Glu Ser Pro Lys Pro Val Lys His Gln Gly Glu Leu 
    210                 215                 220                 


Glu Arg Gln Leu Leu Gln Ala Asn Pro Ile Leu Glu Ser Phe Gly Asn 
225                 230                 235                 240 


Ala Lys Thr Val Lys Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile 
                245                 250                 255     


Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile Val Gly Ala Asn Ile Glu 
            260                 265                 270         


Thr Tyr Leu Leu Glu Lys Ser Arg Ala Val Arg Gln Ala Lys Asp Glu 
        275                 280                 285             


Arg Thr Phe His Ile Phe Tyr Gln Leu Leu Ser Gly Ala Gly Glu His 
    290                 295                 300                 


Leu Lys Ser Asp Leu Leu Leu Glu Gly Phe Asn Asn Tyr Arg Phe Leu 
305                 310                 315                 320 


Ser Asn Gly Tyr Ile Pro Ile Pro Gly Gln Gln Asp Lys Asp Asn Phe 
                325                 330                 335     


Gln Glu Thr Met Glu Ala Met His Ile Met Gly Phe Ser His Glu Glu 
            340                 345                 350         


Ile Leu Ser Met Leu Lys Val Val Ser Ser Val Leu Gln Phe Gly Asn 
        355                 360                 365             


Ile Ser Phe Lys Lys Glu Arg Asn Thr Asp Gln Ala Ser Met Pro Glu 
    370                 375                 380                 


Asn Thr Val Ala Gln Lys Leu Cys His Leu Leu Gly Met Asn Val Met 
385                 390                 395                 400 


Glu Phe Thr Arg Ala Ile Leu Thr Pro Arg Ile Lys Val Gly Arg Asp 
                405                 410                 415     


Tyr Val Gln Lys Ala Gln Thr Lys Glu Gln Ala Asp Phe Ala Val Glu 
            420                 425                 430         


Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu Phe Arg Trp Leu Val His 
        435                 440                 445             


Arg Ile Asn Lys Ala Leu Asp Arg Thr Lys Arg Gln Gly Ala Ser Phe 
    450                 455                 460                 


Ile Gly Ile Leu Asp Ile Ala Gly Phe Glu Ile Phe Glu Leu Asn Ser 
465                 470                 475                 480 


Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn Glu Lys Leu Gln Gln Leu 
                485                 490                 495     


Phe Asn His Thr Met Phe Ile Leu Glu Gln Glu Glu Tyr Gln Arg Glu 
            500                 505                 510         


Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly Leu Asp Leu Gln Pro Cys 
        515                 520                 525             


Ile Asp Leu Ile Glu Arg Pro Ala Asn Pro Pro Gly Val Leu Ala Leu 
    530                 535                 540                 


Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala Thr Asp Lys Thr Phe Val 
545                 550                 555                 560 


Glu Lys Leu Val Gln Glu Gln Gly Ser His Ser Lys Phe Gln Lys Pro 
                565                 570                 575     


Arg Gln Leu Lys Asp Lys Ala Asp Phe Cys Ile Ile His Tyr Ala Gly 
            580                 585                 590         


Lys Val Asp Tyr Lys Ala Asp Glu Trp Leu Met Lys Asn Met Asp Pro 
        595                 600                 605             


Leu Asn Asp Asn Val Ala Thr Leu Leu His Gln Ser Ser Asp Arg Phe 
    610                 615                 620                 


Val Ala Glu Leu Trp Lys Asp Glu Ile Gln Asn Ile Gln Arg Ala Ser 
625                 630                 635                 640 


Phe Tyr Asp Ser Val Ser Gly Leu His Glu Pro Pro Val Asp Arg Ile 
                645                 650                 655     


Val Gly Leu Asp Gln Val Thr Gly Met Thr Glu Thr Ala Phe Gly Ser 
            660                 665                 670         


Ala Tyr Lys Thr Lys Lys Gly Met Phe Arg Thr Val Gly Gln Leu Tyr 
        675                 680                 685             


Lys Glu Ser Leu Thr Lys Leu Met Ala Thr Leu Arg Asn Thr Asn Pro 
    690                 695                 700                 


Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ala Gly Lys 
705                 710                 715                 720 


Leu Asp Pro His Leu Val Leu Asp Gln Leu Arg Cys Asn Gly Val Leu 
                725                 730                 735     


Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val Phe 
            740                 745                 750         


Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Thr Pro Asn Ala Ile Pro 
        755                 760                 765             


Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Glu Arg Met Ile Arg Ala 
    770                 775                 780                 


Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile Phe 
785                 790                 795                 800 


Phe Arg Ala Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu Lys 
                805                 810                 815     


Ile Thr Asp Ile Ile Ile Phe Phe Gln Ala Val Cys Arg Gly Tyr Leu 
            820                 825                 830         


Ala Arg Lys Ala Phe Ala Lys Lys Gln Gln Gln Leu Ser Ala Leu Lys 
        835                 840                 845             


Val Leu Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg His Trp Gln 
    850                 855                 860                 


Trp Trp Arg Val Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr Arg 
865                 870                 875                 880 


Gln Glu Glu Glu Leu Gln Ala Lys Asp Glu Glu Leu Leu Lys Val Lys 
                885                 890                 895     


Glu Lys Gln Thr Lys Val Glu Gly Glu Leu Glu Glu Met Glu Arg Lys 
            900                 905                 910         


His Gln Gln Leu Leu Glu Glu Lys Asn Ile Leu Ala Glu Gln Leu Gln 
        915                 920                 925             


Ala Glu Thr Glu Leu Phe Ala Glu Ala Glu Glu Met Arg Ala Arg Leu 
    930                 935                 940                 


Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Asp Leu Glu Ser 
945                 950                 955                 960 


Arg Val Glu Glu Glu Glu Glu Arg Asn Gln Ile Leu Gln Asn Glu Lys 
                965                 970                 975     


Lys Lys Met Gln Ala His Ile Gln Asp Leu Glu Glu Gln Leu Asp Glu 
            980                 985                 990         


Glu Glu Gly Ala Arg Gln Lys Leu  Gln Leu Glu Lys Val  Thr Ala Glu 
        995                 1000                 1005             


Ala Lys  Ile Lys Lys Met Glu  Glu Glu Ile Leu Leu  Leu Glu Asp 
    1010                 1015                 1020             


Gln Asn  Ser Lys Phe Ile Lys  Glu Lys Lys Leu Met  Glu Asp Arg 
    1025                 1030                 1035             


Ile Ala  Glu Cys Ser Ser Gln  Leu Ala Glu Glu Glu  Glu Lys Ala 
    1040                 1045                 1050             


Lys Asn  Leu Ala Lys Ile Arg  Asn Lys Gln Glu Val  Met Ile Ser 
    1055                 1060                 1065             


Asp Leu  Glu Glu Arg Leu Lys  Lys Glu Glu Lys Thr  Arg Gln Glu 
    1070                 1075                 1080             


Leu Glu  Lys Ala Lys Arg Lys  Leu Asp Gly Glu Thr  Thr Asp Leu 
    1085                 1090                 1095             


Gln Asp  Gln Ile Ala Glu Leu  Gln Ala Gln Ile Asp  Glu Leu Lys 
    1100                 1105                 1110             


Leu Gln  Leu Ala Lys Lys Glu  Glu Glu Leu Gln Gly  Ala Leu Ala 
    1115                 1120                 1125             


Arg Gly  Asp Asp Glu Thr Leu  His Lys Asn Asn Ala  Leu Lys Val 
    1130                 1135                 1140             


Val Arg  Glu Leu Gln Ala Gln  Ile Ala Glu Leu Gln  Glu Asp Phe 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ala Ser Arg  Asn Lys Ala Glu Lys  Gln Lys Arg 
    1160                 1165                 1170             


Asp Leu  Ser Glu Glu Leu Glu  Ala Leu Lys Thr Glu  Leu Glu Asp 
    1175                 1180                 1185             


Thr Leu  Asp Thr Thr Ala Ala  Gln Gln Glu Leu Arg  Thr Lys Arg 
    1190                 1195                 1200             


Glu Gln  Glu Val Ala Glu Leu  Lys Lys Ala Leu Glu  Glu Glu Thr 
    1205                 1210                 1215             


Lys Asn  His Glu Ala Gln Ile  Gln Asp Met Arg Gln  Arg His Ala 
    1220                 1225                 1230             


Thr Ala  Leu Glu Glu Leu Ser  Glu Gln Leu Glu Gln  Ala Lys Arg 
    1235                 1240                 1245             


Phe Lys  Ala Asn Leu Glu Lys  Asn Lys Gln Gly Leu  Glu Thr Asp 
    1250                 1255                 1260             


Asn Lys  Glu Leu Ala Cys Glu  Val Lys Val Leu Gln  Gln Val Lys 
    1265                 1270                 1275             


Ala Glu  Ser Glu His Lys Arg  Lys Lys Leu Asp Ala  Gln Val Gln 
    1280                 1285                 1290             


Glu Leu  His Ala Lys Val Ser  Glu Gly Asp Arg Leu  Arg Val Glu 
    1295                 1300                 1305             


Leu Ala  Glu Lys Ala Ser Lys  Leu Gln Asn Glu Leu  Asp Asn Val 
    1310                 1315                 1320             


Ser Thr  Leu Leu Glu Glu Ala  Glu Lys Lys Gly Ile  Lys Phe Ala 
    1325                 1330                 1335             


Lys Asp  Ala Ala Ser Leu Glu  Ser Gln Leu Gln Asp  Thr Gln Glu 
    1340                 1345                 1350             


Leu Leu  Gln Glu Glu Thr Arg  Gln Lys Leu Asn Leu  Ser Ser Arg 
    1355                 1360                 1365             


Ile Arg  Gln Leu Glu Glu Glu  Lys Asn Ser Leu Gln  Glu Gln Gln 
    1370                 1375                 1380             


Glu Glu  Glu Glu Glu Ala Arg  Lys Asn Leu Glu Lys  Gln Val Leu 
    1385                 1390                 1395             


Ala Leu  Gln Ser Gln Leu Ala  Asp Thr Lys Lys Lys  Val Asp Asp 
    1400                 1405                 1410             


Asp Leu  Gly Thr Ile Glu Ser  Leu Glu Glu Ala Lys  Lys Lys Leu 
    1415                 1420                 1425             


Leu Lys  Asp Ala Glu Ala Leu  Ser Gln Arg Leu Glu  Glu Lys Ala 
    1430                 1435                 1440             


Leu Ala  Tyr Asp Lys Leu Glu  Lys Thr Lys Asn Arg  Leu Gln Gln 
    1445                 1450                 1455             


Glu Leu  Asp Asp Leu Thr Val  Asp Leu Asp His Gln  Arg Gln Val 
    1460                 1465                 1470             


Ala Ser  Asn Leu Glu Lys Lys  Gln Lys Lys Phe Asp  Gln Leu Leu 
    1475                 1480                 1485             


Ala Glu  Glu Lys Ser Ile Ser  Ala Arg Tyr Ala Glu  Glu Arg Asp 
    1490                 1495                 1500             


Arg Ala  Glu Ala Glu Ala Arg  Glu Lys Glu Thr Lys  Ala Leu Ser 
    1505                 1510                 1515             


Leu Ala  Arg Ala Leu Glu Glu  Ala Leu Glu Ala Lys  Glu Glu Phe 
    1520                 1525                 1530             


Glu Arg  Gln Asn Lys Gln Leu  Arg Ala Asp Met Glu  Asp Leu Met 
    1535                 1540                 1545             


Ser Ser  Lys Asp Asp Val Gly  Lys Asn Val His Glu  Leu Glu Lys 
    1550                 1555                 1560             


Ser Lys  Arg Ala Leu Glu Gln  Gln Val Glu Glu Met  Arg Thr Gln 
    1565                 1570                 1575             


Leu Glu  Glu Leu Glu Asp Glu  Leu Gln Ala Thr Glu  Asp Ala Lys 
    1580                 1585                 1590             


Leu Arg  Leu Glu Val Asn Met  Gln Ala Met Lys Ala  Gln Phe Glu 
    1595                 1600                 1605             


Arg Asp  Leu Gln Thr Arg Asp  Glu Gln Asn Glu Glu  Lys Lys Arg 
    1610                 1615                 1620             


Leu Leu  Ile Lys Gln Val Arg  Glu Leu Glu Ala Glu  Leu Glu Asp 
    1625                 1630                 1635             


Glu Arg  Lys Gln Arg Ala Leu  Ala Val Ala Ser Lys  Lys Lys Met 
    1640                 1645                 1650             


Glu Ile  Asp Leu Lys Asp Leu  Glu Ala Gln Ile Glu  Ala Ala Asn 
    1655                 1660                 1665             


Lys Ala  Arg Asp Glu Val Ile  Lys Gln Leu Arg Lys  Leu Gln Ala 
    1670                 1675                 1680             


Gln Met  Lys Asp Tyr Gln Arg  Glu Leu Glu Glu Ala  Arg Ala Ser 
    1685                 1690                 1695             


Arg Asp  Glu Ile Phe Ala Gln  Ser Lys Glu Ser Glu  Lys Lys Leu 
    1700                 1705                 1710             


Lys Ser  Leu Glu Ala Glu Ile  Leu Gln Leu Gln Glu  Glu Leu Ala 
    1715                 1720                 1725             


Ser Ser  Glu Arg Ala Arg Arg  His Ala Glu Gln Glu  Arg Asp Glu 
    1730                 1735                 1740             


Leu Ala  Asp Glu Ile Thr Asn  Ser Ala Ser Gly Lys  Ser Ala Leu 
    1745                 1750                 1755             


Leu Asp  Glu Lys Arg Arg Leu  Glu Ala Arg Ile Ala  Gln Leu Glu 
    1760                 1765                 1770             


Glu Glu  Leu Glu Glu Glu Gln  Ser Asn Met Glu Leu  Leu Asn Asp 
    1775                 1780                 1785             


Arg Phe  Arg Lys Thr Thr Leu  Gln Val Asp Thr Leu  Asn Ala Glu 
    1790                 1795                 1800             


Leu Ala  Ala Glu Arg Ser Ala  Ala Gln Lys Ser Asp  Asn Ala Arg 
    1805                 1810                 1815             


Gln Gln  Leu Glu Arg Gln Asn  Lys Glu Leu Lys Ala  Lys Leu Gln 
    1820                 1825                 1830             


Glu Leu  Glu Gly Ala Val Lys  Ser Lys Phe Lys Ala  Thr Ile Ser 
    1835                 1840                 1845             


Ala Leu  Glu Ala Lys Ile Gly  Gln Leu Glu Glu Gln  Leu Glu Gln 
    1850                 1855                 1860             


Glu Ala  Lys Glu Arg Ala Ala  Ala Asn Lys Leu Val  Arg Arg Thr 
    1865                 1870                 1875             


Glu Lys  Lys Leu Lys Glu Ile  Phe Met Gln Val Glu  Asp Glu Arg 
    1880                 1885                 1890             


Arg His  Ala Asp Gln Tyr Lys  Glu Gln Met Glu Lys  Ala Asn Ala 
    1895                 1900                 1905             


Arg Met  Lys Gln Leu Lys Arg  Gln Leu Glu Glu Ala  Glu Glu Glu 
    1910                 1915                 1920             


Ala Thr  Arg Ala Asn Ala Ser  Arg Arg Lys Leu Gln  Arg Glu Leu 
    1925                 1930                 1935             


Asp Asp  Ala Thr Glu Ala Asn  Glu Gly Leu Ser Arg  Glu Val Ser 
    1940                 1945                 1950             


Thr Leu  Lys Asn Arg Leu Arg  Arg Gly Gly Pro Ile  Ser Phe Ser 
    1955                 1960                 1965             


Ser Ser  Arg Ser Gly Arg Arg  Gln Leu His Leu Glu  Gly Ala Ser 
    1970                 1975                 1980             


Leu Glu  Leu Ser Asp Asp Asp  Thr Glu Ser Lys Thr  Ser Asp Val 
    1985                 1990                 1995             


Asn Glu  Thr Gln Pro Pro Gln  Ser Glu 
    2000                 2005         


<210> 455
<211> 2732
<212> DNA
<213> Homo sapiens

<400> 455
ctttcgcctc agtctcgagc tctcgctggc cttcgggtgt acgtgctccg ggatcttcag       60

cacccgcggc cgccatcgcc gtcgcttggc ttcttctgga ctcatctgcg ccacttgtcc      120

gcttcacact ccgccgccat catggtgaag ctcgcgaagg caggtaaaaa tcaaggtgac      180

cccaagaaaa tggctcctcc tccaaaggag gtagaagaag atagtgaaga tgaggaaatg      240

tcagaagatg aagaagatga tagcagtgga gaagaggtcg tcatacctca gaagaaaggc      300

aagaaggctg ctgcaacctc agcaaagaag gtggtcgttt ccccaacaaa aaaggttgca      360

gttgccacac cagccaagaa agcagctgtc actccaggca aaaaggcagc agcaacacct      420

gccaagaaga cagttacacc agccaaagca gttaccacac ctggcaagaa gggagccaca      480

ccaggcaaag cattggtagc aactcctggt aagaagggtg ctgccatccc agccaagggg      540

gcaaagaatg gcaagaatgc caagaaggaa gacagtgatg aagaggagga tgatgacagt      600

gaggaggatg aggaggatga cgaggacgag gatgaggatg aagatgaaat tgaaccagca      660

gcgatgaaag cagcagctgc tgcccctgcc tcagaggatg aggacgatga ggatgacgaa      720

gatgatgagg atgacgatga cgatgaggaa gatgactctg aagaagaagc tatggagact      780

acaccagcca aaggaaagaa agctgcaaaa gttgttcctg tgaaagccaa gaacgtggct      840

gaggatgaag atgaagaaga ggatgatgag gacgaggatg acgacgacga cgaagatgat      900

gaagatgatg atgatgaaga tgatgaggag gaggaagaag aggaggagga agagcctgtc      960

aaagaagcac ctggaaaacg aaagaaggaa atggccaaac agaaagcagc tcctgaagcc     1020

aagaaacaga aagtggaagg cacagaaccg actacggctt tcaatctctt tgttggaaac     1080

ctaaacttta acaaatctgc tcctgaatta aaaactggta tcagcgatgt ttttgctaaa     1140

aatgatcttg ctgttgtgga tgtcagaatt ggtatgacta ggaaatttgg ttatgtggat     1200

tttgaatctg ctgaagacct ggagaaagcg ttggaactca ctggtttgaa agtctttggc     1260

aatgaaatta aactagagaa accaaaagga aaagacagta agaaagagcg agatgcgaga     1320

acacttttgg ctaaaaatct cccttacaaa gtcactcagg atgaattgaa agaagtgttt     1380

gaagatgctg cggagatcag attagtcagc aaggatggga aaagtaaagg gattgcttat     1440

attgaattta agacagaagc tgatgcagag aaaacctttg aagaaaagca gggaacagag     1500

atcgatgggc gatctatttc cctgtactat actggagaga aaggtcaaaa tcaagactat     1560

agaggtggaa agaatagcac ttggagtggt gaatcaaaaa ctctggtttt aagcaacctc     1620

tcctacagtg caacagaaga aactcttcag gaagtatttg agaaagcaac ttttatcaaa     1680

gtaccccaga accaaaatgg caaatctaaa gggtatgcat ttatagagtt tgcttcattc     1740

gaagacgcta aagaagcttt aaattcctgt aataaaaggg aaattgaggg cagagcaatc     1800

aggctggagt tgcaaggacc caggggatca cctaatgcca gaagccagcc atccaaaact     1860

ctgtttgtca aaggcctgtc tgaggatacc actgaagaga cattaaagga gtcatttgac     1920

ggctccgttc gggcaaggat agttactgac cgggaaactg ggtcctccaa agggtttggt     1980

tttgtagact tcaacagtga ggaggatgcc aaagctgcca aggaggccat ggaagacggt     2040

gaaattgatg gaaataaagt taccttggac tgggccaaac ctaagggtga aggtggcttc     2100

gggggtcgtg gtggaggcag aggcggcttt ggaggacgag gtggtggtag aggaggccga     2160

ggaggatttg gtggcagagg ccggggaggc tttggagggc gaggaggctt ccgaggaggc     2220

agaggaggag gaggtgacca caagccacaa ggaaagaaga cgaagtttga atagcttctg     2280

tccctctgct ttcccttttc catttgaaag aaaggactct ggggttttta ctgttacctg     2340

atcaatgaca gagccttctg aggacattcc aagacagtat acagtcctgt ggtctccttg     2400

gaaatccgtc tagttaacat ttcaagggca ataccgtgtt ggttttgact ggatattcat     2460

ataaactttt taaagagttg agtgatagag ctaaccctta tctgtaagtt ttgaatttat     2520

attgtttcat cccatgtaca aaaccatttt ttcctacaaa tagtttgggt tttgttgttg     2580

tttctttttt ttgttttgtt tttgtttttt ttttttttgc gttcgtgggg ttgtaaaaga     2640

aaagaaagca gaatgtttta tcatggtttt tgcttcagcg gctttaggac aaattaaaag     2700

tcaactctgg tgccagaaaa aaaaaaaaaa aa                                   2732


<210> 456
<211> 710
<212> PRT
<213> Homo sapiens

<400> 456
Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys 
1               5                   10                  15      


Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu 
            20                  25                  30          


Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile 
        35                  40                  45              


Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val 
    50                  55                  60                  


Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys 
65                  70                  75                  80  


Ala Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys 
                85                  90                  95      


Thr Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala 
            100                 105                 110         


Thr Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala 
        115                 120                 125             


Ile Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp 
    130                 135                 140                 


Ser Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys 
                165                 170                 175     


Ala Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu 
        195                 200                 205             


Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val 
    210                 215                 220                 


Val Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu 
225                 230                 235                 240 


Asp Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp 
                245                 250                 255     


Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro 
            260                 265                 270         


Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys 
        275                 280                 285             


Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr 
    290                 295                 300                 


Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala 
305                 310                 315                 320 


Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu 
                325                 330                 335     


Ala Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val 
            340                 345                 350         


Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly 
        355                 360                 365             


Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys 
    370                 375                 380                 


Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu 
385                 390                 395                 400 


Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala 
                405                 410                 415     


Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala 
            420                 425                 430         


Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu 
        435                 440                 445             


Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr 
    450                 455                 460                 


Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr 
465                 470                 475                 480 


Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser 
                485                 490                 495     


Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile 
            500                 505                 510         


Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile 
        515                 520                 525             


Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn 
    530                 535                 540                 


Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro 
545                 550                 555                 560 


Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val 
                565                 570                 575     


Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe 
            580                 585                 590         


Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser 
        595                 600                 605             


Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys 
    610                 615                 620                 


Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val 
625                 630                 635                 640 


Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg 
                645                 650                 655     


Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly 
            660                 665                 670         


Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly 
        675                 680                 685             


Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly 
    690                 695                 700                 


Lys Lys Thr Lys Phe Glu 
705                 710 


<210> 457
<211> 3656
<212> DNA
<213> Homo sapiens

<400> 457
agcgatccga ggcccggccc cggccccgcc ccgcgccgcg ccgcgccgct tgccgccggg       60

ctagcactga cgtgtctctc ggcggagctg ctgtgcagtg gaacgcgctg ggccgcgggc      120

agcgtcgcct cacgcggagc agagctgagc tgaagcggga cccggagccc gagcagccgc      180

cgccatggca atcaaatttc tggaagtcat caagcccttc tgtgtcatcc tgccggaaat      240

tcagaagcca gagaggaaga ttcagtttaa ggagaaagtg ctgtggaccg ctatcaccct      300

ctttatcttc ttagtgtgct gccagattcc cctgtttggg atcatgtctt cagattcagc      360

tgaccctttc tattggatga gagtgattct agcctctaac agaggcacat tgatggagct      420

agggatctct cctattgtca cgtctggcct tataatgcaa ctcttggctg gcgccaagat      480

aattgaagtt ggtgacaccc caaaagaccg agctctcttc aacggagccc aaaagttatt      540

tggcatgatc attactatcg gccagtctat cgtgtatgtg atgaccggga tgtatgggga      600

cccttctgaa atgggtgctg gaatttgcct gctaatcacc attcagctct ttgttgctgg      660

cttaattgtc ctacttttgg atgaactcct gcaaaaagga tatggccttg gctctggtat      720

ttctctcttc attgcaacta acatctgtga aaccatcgta tggaaggcat tcagccccac      780

tactgtcaac actggccgag gaatggaatt tgaaggtgct atcatcgcac ttttccatct      840

gctggccaca cgcacagaca aggtccgagc ccttcgggag gcgttctacc gccagaatct      900

tcccaacctc atgaatctca tcgccaccat ctttgtcttt gcagtggtca tctatttcca      960

gggcttccga gtggacctgc caatcaagtc ggcccgctac cgtggccagt acaacaccta     1020

tcccatcaag ctcttctata cgtccaacat ccccatcatc ctgcagtctg ccctggtgtc     1080

caacctttat gtcatctccc aaatgctctc agctcgcttc agtggcaact tgctggtcag     1140

cctgctgggc acctggtcgg acacgtcttc tgggggccca gcacgtgctt atccagttgg     1200

tggcctttgc tattacctgt cccctccaga atcttttggc tccgtgttag aagacccggt     1260

ccatgcagtt gtatacatag tgttcatgct gggctcctgt gcattcttct ccaaaacgtg     1320

gattgaggtc tcaggttcct ctgccaaaga tgttgcaaag cagctgaagg agcagcagat     1380

ggtgatgaga ggccaccgag agacctccat ggtccatgaa ctcaaccggt acatccccac     1440

agccgcggcc tttggtgggc tgtgcatcgg ggccctctcg gtcctggctg acttcctagg     1500

cgccattggg tctggaaccg ggatcctgct cgcagtcaca atcatctacc agtactttga     1560

gatcttcgtt aaggagcaaa gcgaggttgg cagcatgggg gccctgctct tctgagcccg     1620

tctcccggac aggttgagga agctgctcca gaagcgcctc ggaaggggag ctctcatcat     1680

ggcgcgtgct gctgcggcat atggactttt aataatgttt ttgaatttcg tattctttca     1740

ttccactgtg taaagtgcta gacattttcc aatttaaaat tttgcttttt atcctggcac     1800

tggcaaaaag aactgtgaaa gtgaaatttt attcagccga ctgccagaga agtgggaatg     1860

gtataggatt gtccccaagt gtccatgtaa cttttgtttt aacctttgca ccttctcagt     1920

gctgtatgcg gctgcagccg tctcacctgt ttccccacaa agggaatttc tcactctggt     1980

tggaagcaca aacactgaaa tgtctacgtt tcattttggc agtagggtgt gaagctggga     2040

gcagatcatg tatttcccgg agacgtggga ccttgctggc atgtctcctt cacaatcagg     2100

cgtgggaata tctggcttag gactgtttct ctctaagaca ccattgtttt cccttatttt     2160

aaaagtgatt tttttaagga cagaacttct tccaaaagag agggatggct ttcccagaag     2220

acactcctgg ccatctgtgg atttgtctgt gcacctattg gctcttctag ctgactcttc     2280

tggttgggct tagagtctgc ctgtttctgc tagctccgtg tttagtccac ttgggtcatc     2340

agctctgcca agctgagcct ggccaagcta ggtggacaga cccttgcagt gatgtccgtt     2400

tgtccagatt ctgccagtca tcactggaca cgtctcctcg cagctgccct agcaagggga     2460

gacattgtgg tagctatcag acatggacag aaactgactt agtgctcaca agcccctaca     2520

ccttctgggc tgaagatcac ccagctgtgt tcagaatttt cttactgtgc ttaggactgc     2580

acgcaagtga gcagacacca ccgacttcct ttctgcgtca ccagtgtcgt cagcagagag     2640

aggacagcac aggctcaagg ttggtagtga agtcaggttc ggggtgcatg ggctgtggtg     2700

gtgttgatca gttgctccag tgtttgaaat aagaagactc atgtttatgt ctggaataag     2760

ttctgtttgt gctgacaggt ggcctaggtc ctggagatga gcaccctctc tctggccttt     2820

agggagtccc ctcttaggac aggcactgcc cagcagcaag ggcagcagag ttgggtgcta     2880

agatcctgag gagctcgagg tttcgagctg gctttagaca ttggtgggac caaggatgtt     2940

ttgcaggatg ccctgatcct aagaaggggg cctgggggtg cgtgcagcct gtcggggaga     3000

ccccactctg acagtgggca cacggcagcc tgcaaagcac agggccaccg ccacagcccg     3060

gcagaggggc acactctgga gaccttgctg gcagtgctag ccaggaaaca gagtgaccaa     3120

gggacaagaa gggacttgcc taaagccacc cagcaactca gcagcagaac caagatgggc     3180

cccaggctcc tccatatggc ccagggctta ccaccctatc acacgtggcc ttgtctagac     3240

ccagtcctga gcaggggaga ggctcttgag acctgatgcc ctcctaccca catggttctc     3300

ccactgccct gtctgctctg ctgctacaga ggggcagggc ctcccccagc ccacgcttag     3360

gaatgcttgg cctctggcag gcaggcagct gtacccaagc tggtgggcag ggggctggaa     3420

ggcaccaggc ctcaggagga gccccatagt cccgcctgca gcctgtaacc atcggctggg     3480

ccctgcaagg cccacactca cgccctgtgg gtgatggtca cggtgggtgg gtgggggctg     3540

accccagctt ccaggggact gtcactgtgg acgccaaaat ggcataactg agataaggtg     3600

aataagtgac aaataaagcc agttttttac aaggtaaaaa aaaaaaaaaa aaaaaa         3656


<210> 458
<211> 476
<212> PRT
<213> Homo sapiens

<400> 458
Met Ala Ile Lys Phe Leu Glu Val Ile Lys Pro Phe Cys Val Ile Leu 
1               5                   10                  15      


Pro Glu Ile Gln Lys Pro Glu Arg Lys Ile Gln Phe Lys Glu Lys Val 
            20                  25                  30          


Leu Trp Thr Ala Ile Thr Leu Phe Ile Phe Leu Val Cys Cys Gln Ile 
        35                  40                  45              


Pro Leu Phe Gly Ile Met Ser Ser Asp Ser Ala Asp Pro Phe Tyr Trp 
    50                  55                  60                  


Met Arg Val Ile Leu Ala Ser Asn Arg Gly Thr Leu Met Glu Leu Gly 
65                  70                  75                  80  


Ile Ser Pro Ile Val Thr Ser Gly Leu Ile Met Gln Leu Leu Ala Gly 
                85                  90                  95      


Ala Lys Ile Ile Glu Val Gly Asp Thr Pro Lys Asp Arg Ala Leu Phe 
            100                 105                 110         


Asn Gly Ala Gln Lys Leu Phe Gly Met Ile Ile Thr Ile Gly Gln Ser 
        115                 120                 125             


Ile Val Tyr Val Met Thr Gly Met Tyr Gly Asp Pro Ser Glu Met Gly 
    130                 135                 140                 


Ala Gly Ile Cys Leu Leu Ile Thr Ile Gln Leu Phe Val Ala Gly Leu 
145                 150                 155                 160 


Ile Val Leu Leu Leu Asp Glu Leu Leu Gln Lys Gly Tyr Gly Leu Gly 
                165                 170                 175     


Ser Gly Ile Ser Leu Phe Ile Ala Thr Asn Ile Cys Glu Thr Ile Val 
            180                 185                 190         


Trp Lys Ala Phe Ser Pro Thr Thr Val Asn Thr Gly Arg Gly Met Glu 
        195                 200                 205             


Phe Glu Gly Ala Ile Ile Ala Leu Phe His Leu Leu Ala Thr Arg Thr 
    210                 215                 220                 


Asp Lys Val Arg Ala Leu Arg Glu Ala Phe Tyr Arg Gln Asn Leu Pro 
225                 230                 235                 240 


Asn Leu Met Asn Leu Ile Ala Thr Ile Phe Val Phe Ala Val Val Ile 
                245                 250                 255     


Tyr Phe Gln Gly Phe Arg Val Asp Leu Pro Ile Lys Ser Ala Arg Tyr 
            260                 265                 270         


Arg Gly Gln Tyr Asn Thr Tyr Pro Ile Lys Leu Phe Tyr Thr Ser Asn 
        275                 280                 285             


Ile Pro Ile Ile Leu Gln Ser Ala Leu Val Ser Asn Leu Tyr Val Ile 
    290                 295                 300                 


Ser Gln Met Leu Ser Ala Arg Phe Ser Gly Asn Leu Leu Val Ser Leu 
305                 310                 315                 320 


Leu Gly Thr Trp Ser Asp Thr Ser Ser Gly Gly Pro Ala Arg Ala Tyr 
                325                 330                 335     


Pro Val Gly Gly Leu Cys Tyr Tyr Leu Ser Pro Pro Glu Ser Phe Gly 
            340                 345                 350         


Ser Val Leu Glu Asp Pro Val His Ala Val Val Tyr Ile Val Phe Met 
        355                 360                 365             


Leu Gly Ser Cys Ala Phe Phe Ser Lys Thr Trp Ile Glu Val Ser Gly 
    370                 375                 380                 


Ser Ser Ala Lys Asp Val Ala Lys Gln Leu Lys Glu Gln Gln Met Val 
385                 390                 395                 400 


Met Arg Gly His Arg Glu Thr Ser Met Val His Glu Leu Asn Arg Tyr 
                405                 410                 415     


Ile Pro Thr Ala Ala Ala Phe Gly Gly Leu Cys Ile Gly Ala Leu Ser 
            420                 425                 430         


Val Leu Ala Asp Phe Leu Gly Ala Ile Gly Ser Gly Thr Gly Ile Leu 
        435                 440                 445             


Leu Ala Val Thr Ile Ile Tyr Gln Tyr Phe Glu Ile Phe Val Lys Glu 
    450                 455                 460                 


Gln Ser Glu Val Gly Ser Met Gly Ala Leu Leu Phe 
465                 470                 475     


<210> 459
<211> 3874
<212> DNA
<213> Homo sapiens

<400> 459
ctaggcggcg gcggccgggt ccccaaggct gggcgctgct tgcggaaccg acggggcgga       60

gaggagcgtg gcgggaggag gagtaggaga agggggctgg tcaagggaag tgcgacgtgt      120

ctgcggagcc tttttatacc tccttcccgg gagtccggca gccgctgctg ctgctgctgc      180

tgctgctgcc gccgccgccg ccgccgtccc tgcgtccttc ggtctctgct cccgggaccc      240

gggctccgcc gcagccagcc agcatgtcgg ggatcaagaa gcaaaagacg gagaaccagc      300

agaaatccac caatgtagtc tatcaggccc accatgtgag caggaataag agagggcaag      360

tggttggaac aaggggtggg ttccgaggat gtaccgtgtg gctaacaggt ctctctggtg      420

ctggaaaaac aacgataagt tttgccctgg aggagtacct tgtctcccat gccatccctt      480

gttactccct ggatggggac aatgtccgtc atggccttaa cagaaatctc ggattctctc      540

ctggggacag agaggaaaat atccgccgga ttgctgaggt ggctaagctg tttgctgatg      600

ctggtctggt ctgcattacc agctttattt ctccattcgc aaaggatcgt gagaatgccc      660

gcaaaataca tgaatcagca gggctgccat tctttgaaat atttgtagat gcacctctaa      720

atatttgtga aagcagagac gtaaaaggcc tctataaaag ggccagagct ggggagatta      780

aaggatttac aggtattgat tctgattatg agaaacctga aactcctgag cgtgtgctta      840

aaaccaattt gtccacagtg agtgactgtg tccaccaggt agtggaactt ctgcaagagc      900

agaacattgt accctatact ataatcaaag atatccacga actctttgtg ccggaaaaca      960

aacttgacca cgtccgagct gaggctgaaa ctctcccttc attatcaatt actaagctgg     1020

atctccagtg ggtccaggtt ttgagcgaag gctgggccac tcccctcaaa ggtttcatgc     1080

gggagaagga gtacttacag gttatgcact ttgacaccct gctagatggc atggcccttc     1140

ctgatggcgt gatcaacatg agcatcccca ttgtactgcc cgtctctgca gaggataaga     1200

cacggctgga agggtgcagc aagtttgtcc tggcacatgg tggacggagg gtagctatct     1260

tacgagacgc tgaattctat gaacacagaa aagaggaacg ctgttcccgt gtttggggga     1320

caacatgtac aaaacacccc catatcaaaa tggtgatgga aagtggggac tggctggttg     1380

gtggagacct tcaggtgctg gagaaaataa gatggaatga tgggctggac caataccgtc     1440

tgacacctct ggagctcaaa cagaaatgta aagaaatgaa tgctgatgcg gtgtttgcat     1500

tccagttgcg caatcctgtc cacaatggcc atgccctgtt gatgcaggac actcgccgca     1560

ggctcctaga gaggggctac aagcacccgg tcctcctact acaccctctg ggcggctgga     1620

ccaaggatga cgatgtgcct ctagactggc ggatgaagca gcacgcggct gtgctcgagg     1680

aaggggtcct ggatcccaag tcaaccattg ttgccatctt tccgtctccc atgttatatg     1740

ctggccccac agaggtccag tggcactgca ggtcccggat gattgcgggt gccaatttct     1800

acattgtggg gagggaccct gcaggaatgc cccatcctga aaccaagaag gatctgtatg     1860

aacccactca tgggggcaag gtcttgagca tggcccctgg cctcacctct gtggaaatca     1920

ttccattccg agtggctgcc tacaacaaag ccaaaaaagc catggacttc tatgatccag     1980

caaggcacaa tgagtttgac ttcatctcag gaactcgaat gaggaagctc gcccgggaag     2040

gagagaatcc cccagatggc ttcatggccc ccaaagcatg gaaggtcctg acagattatt     2100

acaggtccct ggagaagaac taagcctttg gctccagagt ttctttctga agtgctcttt     2160

gattaccttt tctattttta tgattagatg ctttgtatta aattgcttct caatgatgca     2220

ttttaatctt ttataatgaa gtaaaagttg tgtctataat taaaaaaaaa tatatatata     2280

tacacacaca catatacata caaagtcaaa ctgaagacca aatcttagca ggtaaaagca     2340

atattcttat acatttcata ataaaattag ctctatgtat tttctactgc acctgagcag     2400

gcaggtccca gatttcttaa ggctttgttt gaccatgtgt ctagttactt gctgaaaagt     2460

gaatatattt tccagcatgt cttgacaacc tgtactcttc caatgtcatt tatcagttgt     2520

aaaatatatc agattgtgtc ctcttctgta caattgacaa aaaaaaaaat ttttttttct     2580

cactctaaaa gaggtgtggc tcacatcaag attcttcctg atattttacc tcatgctgta     2640

caaagcctta atgttgtaat catatcttac gtgttgaaga cctgactgga gaaacaaaat     2700

gtgcaataac gtgaatttta tcttagagat ctgtgcagcc tatttctgtc acaaaagtta     2760

tattgtctaa taagagaagt cttaatggcc tctgtgaata atgtaactcc agttacacgg     2820

tgacttttaa tagcatacag tgatttgatg aaaggacgtc aaacaatgtg gcgatgtcgt     2880

ggaaagttat ctttcccgct ctttgctgtg gtcattgtgt cttgcagaaa ggatggccct     2940

gatgcagcag cagcgccagc tgtaataaaa aataattcac actatcagac tagcaaggca     3000

ctagaactgg aaaagaccac agaaaacaaa gaatccaacc ctttcatctt acaggtgaac     3060

aaactgtgat gatgcacatg tatgtgtttt gtaagctgtg agcaccgtaa caaaatgtaa     3120

atttgccatt attaggaagt gctggtggca gtgaagaagc acccaggcca cttgactccc     3180

agtctggtgc cctgtctaca ccagacaaca caggagctgg gtcagattcc cctcagctgc     3240

ttaacaaagt tcctcgaaca gaaagtgctt acaaagctgc cttctcggat actgaaaggt     3300

cgagttttct gaactgcact gattttattg cagttgaaaa aaaaaaaaag ctattccaaa     3360

gatttcaagc tgttctgaga catcttctga tggctttact tcctgagagg caatgttttt     3420

actttatgca taattcattg ttgccaagga ataaagtgaa gaaacagcac cttttaatat     3480

ataggtctct ctggaagaga cctaaattag aaagagaaaa ctgtgacaat tttcatattc     3540

tcattcttaa aaaacactaa tcttaactaa caaaagttct tttgagaata agttacacac     3600

aatggccaca gcagtttgtc tttaatagta tagtgcctat actcatgtaa tcggttactc     3660

actactgcct ttaaaaaaaa aaaccagcat atttattgaa aacatgagac aggattatag     3720

tgccttaacc gatatatttt gtgacttaaa aaatacattt aaaactgctc ttctgctcta     3780

gtaccatgct tagtgcaaat gattatttct atgtacaact gatgcttgtt cttattttaa     3840

taaatttatc agagtgaaaa aaaaaaaaaa aaaa                                 3874


<210> 460
<211> 619
<212> PRT
<213> Homo sapiens

<400> 460
Met Ser Gly Ile Lys Lys Gln Lys Thr Glu Asn Gln Gln Lys Ser Thr 
1               5                   10                  15      


Asn Val Val Tyr Gln Ala His His Val Ser Arg Asn Lys Arg Gly Gln 
            20                  25                  30          


Val Val Gly Thr Arg Gly Gly Phe Arg Gly Cys Thr Val Trp Leu Thr 
        35                  40                  45              


Gly Leu Ser Gly Ala Gly Lys Thr Thr Ile Ser Phe Ala Leu Glu Glu 
    50                  55                  60                  


Tyr Leu Val Ser His Ala Ile Pro Cys Tyr Ser Leu Asp Gly Asp Asn 
65                  70                  75                  80  


Val Arg His Gly Leu Asn Arg Asn Leu Gly Phe Ser Pro Gly Asp Arg 
                85                  90                  95      


Glu Glu Asn Ile Arg Arg Ile Ala Glu Val Ala Lys Leu Phe Ala Asp 
            100                 105                 110         


Ala Gly Leu Val Cys Ile Thr Ser Phe Ile Ser Pro Phe Ala Lys Asp 
        115                 120                 125             


Arg Glu Asn Ala Arg Lys Ile His Glu Ser Ala Gly Leu Pro Phe Phe 
    130                 135                 140                 


Glu Ile Phe Val Asp Ala Pro Leu Asn Ile Cys Glu Ser Arg Asp Val 
145                 150                 155                 160 


Lys Gly Leu Tyr Lys Arg Ala Arg Ala Gly Glu Ile Lys Gly Phe Thr 
                165                 170                 175     


Gly Ile Asp Ser Asp Tyr Glu Lys Pro Glu Thr Pro Glu Arg Val Leu 
            180                 185                 190         


Lys Thr Asn Leu Ser Thr Val Ser Asp Cys Val His Gln Val Val Glu 
        195                 200                 205             


Leu Leu Gln Glu Gln Asn Ile Val Pro Tyr Thr Ile Ile Lys Asp Ile 
    210                 215                 220                 


His Glu Leu Phe Val Pro Glu Asn Lys Leu Asp His Val Arg Ala Glu 
225                 230                 235                 240 


Ala Glu Thr Leu Pro Ser Leu Ser Ile Thr Lys Leu Asp Leu Gln Trp 
                245                 250                 255     


Val Gln Val Leu Ser Glu Gly Trp Ala Thr Pro Leu Lys Gly Phe Met 
            260                 265                 270         


Arg Glu Lys Glu Tyr Leu Gln Val Met His Phe Asp Thr Leu Leu Asp 
        275                 280                 285             


Gly Met Ala Leu Pro Asp Gly Val Ile Asn Met Ser Ile Pro Ile Val 
    290                 295                 300                 


Leu Pro Val Ser Ala Glu Asp Lys Thr Arg Leu Glu Gly Cys Ser Lys 
305                 310                 315                 320 


Phe Val Leu Ala His Gly Gly Arg Arg Val Ala Ile Leu Arg Asp Ala 
                325                 330                 335     


Glu Phe Tyr Glu His Arg Lys Glu Glu Arg Cys Ser Arg Val Trp Gly 
            340                 345                 350         


Thr Thr Cys Thr Lys His Pro His Ile Lys Met Val Met Glu Ser Gly 
        355                 360                 365             


Asp Trp Leu Val Gly Gly Asp Leu Gln Val Leu Glu Lys Ile Arg Trp 
    370                 375                 380                 


Asn Asp Gly Leu Asp Gln Tyr Arg Leu Thr Pro Leu Glu Leu Lys Gln 
385                 390                 395                 400 


Lys Cys Lys Glu Met Asn Ala Asp Ala Val Phe Ala Phe Gln Leu Arg 
                405                 410                 415     


Asn Pro Val His Asn Gly His Ala Leu Leu Met Gln Asp Thr Arg Arg 
            420                 425                 430         


Arg Leu Leu Glu Arg Gly Tyr Lys His Pro Val Leu Leu Leu His Pro 
        435                 440                 445             


Leu Gly Gly Trp Thr Lys Asp Asp Asp Val Pro Leu Asp Trp Arg Met 
    450                 455                 460                 


Lys Gln His Ala Ala Val Leu Glu Glu Gly Val Leu Asp Pro Lys Ser 
465                 470                 475                 480 


Thr Ile Val Ala Ile Phe Pro Ser Pro Met Leu Tyr Ala Gly Pro Thr 
                485                 490                 495     


Glu Val Gln Trp His Cys Arg Ser Arg Met Ile Ala Gly Ala Asn Phe 
            500                 505                 510         


Tyr Ile Val Gly Arg Asp Pro Ala Gly Met Pro His Pro Glu Thr Lys 
        515                 520                 525             


Lys Asp Leu Tyr Glu Pro Thr His Gly Gly Lys Val Leu Ser Met Ala 
    530                 535                 540                 


Pro Gly Leu Thr Ser Val Glu Ile Ile Pro Phe Arg Val Ala Ala Tyr 
545                 550                 555                 560 


Asn Lys Ala Lys Lys Ala Met Asp Phe Tyr Asp Pro Ala Arg His Asn 
                565                 570                 575     


Glu Phe Asp Phe Ile Ser Gly Thr Arg Met Arg Lys Leu Ala Arg Glu 
            580                 585                 590         


Gly Glu Asn Pro Pro Asp Gly Phe Met Ala Pro Lys Ala Trp Lys Val 
        595                 600                 605             


Leu Thr Asp Tyr Tyr Arg Ser Leu Glu Lys Asn 
    610                 615                 


<210> 461
<211> 4
<212> PRT
<213> Homo sapiens

<400> 461
Asp Glu Ala Asp
1          



