                         SEQUENCE LISTING

<110>  Quark Pharmaceuticals, Inc.
            FEINSTEIN, Elena
            AVKIN-NACHUM, Sharon
            KALINSKI, Hagar
            METT, Igor
 
<120>  DOUBLE-STRANDED OLIGONUCLEOTIDE MOLECULES TO DDIT4 AND METHODS OF
        USE THEREOF

<130>  232/PCT1

<150>  61/699,884
<151>  2012-09-12

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  1752
<212>  RNA
<213>  HomoSapiens

<400>  1
agggcgcagc aggccaaggg ggaggugcga gcguggaccu gggacggguc ugggcggcuc       60

ucggugguug gcacggguuc gcacacccau ucaagcggca ggacgcacuu gucuuagcag      120

uucucgcuga ccgcgcuagc ugcggcuucu acgcuccggc acucugaguu caucagcaaa      180

cgcccuggcg ucuguccuca ccaugccuag ccuuugggac cgcuucucgu cgucguccac      240

cuccucuucg cccucguccu ugccccgaac ucccacccca gaucggccgc cgcgcucagc      300

cugggggucg gcgacccggg aggagggguu ugaccgcucc acgagccugg agagcucgga      360

cugcgagucc cuggacagca gcaacagugg cuucgggccg gaggaagaca cggcuuaccu      420

ggauggggug ucguugcccg acuucgagcu gcucagugac ccugaggaug aacacuugug      480

ugccaaccug augcagcugc ugcaggagag ccuggcccag gcgcggcugg gcucucgacg      540

cccugcgcgc cugcugaugc cuagccaguu gguaagccag gugggcaaag aacuacugcg      600

ccuggccuac agcgagccgu gcggccugcg gggggcgcug cuggacgucu gcguggagca      660

gggcaagagc ugccacagcg ugggccagcu ggcacucgac cccagccugg ugcccaccuu      720

ccagcugacc cucgugcugc gccuggacuc acgacucugg cccaagaucc aggggcuguu      780

uagcuccgcc aacucucccu uccucccugg cuucagccag ucccugacgc ugagcacugg      840

cuuccgaguc aucaagaaga agcuguacag cucggaacag cugcucauug aggaguguug      900

aacuucaacc ugagggggcc gacagugccc uccaagacag agacgacuga acuuuugggg      960

uggagacuag aggcaggagc ugagggacug auuccugugg uuggaaaacu gaggcagcca     1020

ccuaaggugg agguggggga auaguguuuc ccaggaagcu cauugaguug ugugcgggug     1080

gcugugcauu ggggacacau accccucagu acuguagcau gaaacaaagg cuuaggggcc     1140

aacaaggcuu ccagcuggau guguguguag cauguaccuu auuauuuuug uuacugacag     1200

uuaacagugg ugugacaucc agagagcagc ugggcugcuc ccgccccagc ccggcccagg     1260

gugaaggaag aggcacgugc uccucagagc agccggaggg aggggggagg ucggaggucg     1320

uggagguggu uuguguaucu uacuggucug aagggaccaa guguguuugu uguuuguuuu     1380

guaucuuguu uuucugaucg gagcaucacu acugaccugu uguaggcagc uaucuuacag     1440

acgcaugaau guaagaguag gaaggggugg gugucaggga ucacuuggga ucuuugacac     1500

uugaaaaauu acaccuggca gcugcguuua agccuucccc caucguguac ugcagaguug     1560

agcuggcagg ggaggggcug agaggguggg ggcuggaacc ccuccccggg aggagugcca     1620

ucugggucuu ccaucuagaa cuguuuacau gaagauaaga uacucacugu ucaugaauac     1680

acuugauguu caaguauuaa gaccuaugca auauuuuuua cuuuucuaau aaacauguuu     1740

guuaaaacag uu                                                         1752


<210>  2
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser Ser 
1               5                   10                  15      


Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg Ser 
            20                  25                  30          


Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr Ser 
        35                  40                  45              


Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly Phe 
    50                  55                  60                  


Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro Asp 
65                  70                  75                  80  


Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn Leu 
                85                  90                  95      


Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser Arg 
            100                 105                 110         


Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val Gly 
        115                 120                 125             


Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg Gly 
    130                 135                 140                 


Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser Val 
145                 150                 155                 160 


Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu Thr 
                165                 170                 175     


Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly Leu 
            180                 185                 190         


Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser Leu 
        195                 200                 205             


Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser Ser 
    210                 215                 220                 


Glu Gln Leu Leu Ile Glu Glu Cys 
225                 230         


<210>  3
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  3
cccucaguac uguagcau                                                     18


<210>  4
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  4
ggcagcuauc uuacagac                                                     18


<210>  5
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  5
agagcucgga cugcgagu                                                     18


<210>  6
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  6
gggucuucca ucuagaac                                                     18


<210>  7
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  7
gguggagacu agaggcag                                                     18


<210>  8
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  8
ccuccaagac agagacga                                                     18


<210>  9
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  9
ggaagcucau ugaguugu                                                     18


<210>  10
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  10
gcagcugcgu uuaagccu                                                     18


<210>  11
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  11
caguacugua gcaugaaa                                                     18


<210>  12
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  12
augcuacagu acugaggg                                                     18


<210>  13
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  13
gucuguaaga uagcugcc                                                     18


<210>  14
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  14
acucgcaguc cgagcucu                                                     18


<210>  15
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  15
guucuagaug gaagaccc                                                     18


<210>  16
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  16
cugccucuag ucuccacc                                                     18


<210>  17
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  17
ucgucucugu cuuggagg                                                     18


<210>  18
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  18
acaacucaau gagcuucc                                                     18


<210>  19
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  19
aggcuuaaac gcagcugc                                                     18


<210>  20
<211>  18
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  20
uuucaugcua caguacug                                                     18


<210>  21
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  21
cccucaguac uguagcaua                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  22
ggcagcuauc uuacagaca                                                    19


<210>  23
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  23
agagcucgga cugcgagua                                                    19


<210>  24
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  24
gggucuucca ucuagaaca                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  25
gguggagacu agaggcaga                                                    19


<210>  26
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  26
ccuccaagac agagacgaa                                                    19


<210>  27
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  27
ggaagcucau ugaguugua                                                    19


<210>  28
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  28
gcagcugcgu uuaagccua                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  29
caguacugua gcaugaaau                                                    19


<210>  30
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  30
uaugcuacag uacugaggg                                                    19


<210>  31
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  31
ugucuguaag auagcugcc                                                    19


<210>  32
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  32
uacucgcagu ccgagcucu                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  33
uguucuagau ggaagaccc                                                    19


<210>  34
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  34
ucugccucua gucuccacc                                                    19


<210>  35
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  35
uucgucucug ucuuggagg                                                    19


<210>  36
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  36
uacaacucaa ugagcuucc                                                    19


<210>  37
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  37
uaggcuuaaa cgcagcugc                                                    19


<210>  38
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  38
auuucaugcu acaguacug                                                    19


<210>  39
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  39
ccucaguacu guagcauga                                                    19


<210>  40
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  40
cucaguacug uagcaugaa                                                    19


<210>  41
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  41
uacuguagca ugaaacaaa                                                    19


<210>  42
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  42
ucaugcuaca guacugagg                                                    19


<210>  43
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Chemically synthesized

<400>  43
uucaugcuac aguacugag                                                    19


<210>  44
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  44
uuuguuucau gcuacagua                                                    19


