                         SEQUENCE LISTING

<110>  Zealand Pharma A/S
       Boehringer Ingelheim International GmbH
 
<120>  Glucagon analogues

<130>  GRF/FP6921837

<150>  EP 12184744.6
<151>  2012-09-17

<150>  US 61/701,952
<151>  2012-09-17

<150>  US 61/784,294
<151>  2013-03-14

<160>  46    

<170>  PatentIn version 3.3

<210>  1
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  1

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Ser 
            20                  25              


<210>  2
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  2

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Ser Ala 
            20                  25                  


<210>  3
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 2

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Arg Ala 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  4

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Asp Phe Ile Glu Trp Leu Leu Ser Ala 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  5

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  6

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala Glu Asp Phe Val Glu Trp Leu Leu Arg Ala 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  7

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala Glu Asp Phe Val Glu Trp Leu Leu Arg Ala 
            20                  25                  


<210>  8
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  8

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Ser 
            20                  25              


<210>  9
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  9

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Arg 
            20                  25              


<210>  10
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  10

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala His Glu Phe Val Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  11
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  11

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Asp Phe Ile Glu Trp Leu Leu Ser 
            20                  25              


<210>  12
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  12

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Ser Ala 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 2

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  13

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Ser Ala 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 2

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  14

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Asp Phe Ile Glu Trp Leu Leu Ser Ala 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 3

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  15

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Asp Phe Ile Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 6

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  16

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala Glu Asp Phe Val Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  17

His Ala His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Lys Ala Ala Glu Glu Phe Ile Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  18

His Ser His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala His Glu Phe Ile Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  19

His Ala His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala His Glu Phe Val Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 8

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  20

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Lys Asp Phe Ile Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 8

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  21

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Lys Ala Ala Glu Asp Phe Ile Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 8

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  22

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala Lys Asp Phe Ile Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 8

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  23

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 8

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  24

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Lys Ala Ala Glu Asp Phe Val Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X of Claim 8

<220>
<221>  SITE
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Position of a lipophilic or polymeric substituent (Claim 12)

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Lys(Hexadecanoyl-isoGlu) in Claim 14

<400>  25

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Asp Phe Ile Glu Trp Leu Glu Ser Ala 
            20                  25                  


<210>  26
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  26

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  27
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  27

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  28
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  28

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  29
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  VARIANT
<222>  (29)..(48)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  29

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Ser Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


<210>  30
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  30

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Ser Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  31
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  31

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Asp Phe Ile Glu Trp Leu Leu Ser Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  32
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  32

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Glu Ser Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  33
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  33

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala Glu Asp Phe Val Glu Trp Leu Leu Arg Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  34
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  34

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala Glu Asp Phe Val Glu Trp Leu Leu Arg Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  35
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  VARIANT
<222>  (29)..(48)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  35

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Ser Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


<210>  36
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  VARIANT
<222>  (29)..(48)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  36

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Arg Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


<210>  37
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  37

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala His Glu Phe Val Glu Trp Leu Glu Ser Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  38
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  VARIANT
<222>  (29)..(48)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  38

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Asp Phe Ile Glu Trp Leu Leu Ser Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


<210>  39
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  39

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Ser Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  40
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 3

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  40

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Asp Phe Ile Glu Trp Leu Glu Ser Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  41
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 6

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  41

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala Glu Asp Phe Val Glu Trp Leu Glu Ser Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  42
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  42

His Ala His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Lys Ala Ala Glu Glu Phe Ile Glu Trp Leu Glu Ser Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  43
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  43

His Ser His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala His Glu Phe Ile Glu Trp Leu Glu Ser Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  44
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct: Peptide X-Z of Claim 1

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  VARIANT
<222>  (30)..(49)
<223>  May be present or absent. If present, represents  a sequence of 
       1-20 amino acid units independently selected from the group 
       consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, 
       Dpr and Orn

<400>  44

His Ala His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Ala His Glu Phe Val Glu Trp Leu Glu Ser Ala Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa 
    


<210>  45
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Pro Pro Cys Gln Pro Gln Arg Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Cys Gln Pro Gln Val Pro Ser Ala Gln Val Met Asp Phe Leu 
            20                  25                  30          


Phe Glu Lys Trp Lys Leu Tyr Gly Asp Gln Cys His His Asn Leu Ser 
        35                  40                  45              


Leu Leu Pro Pro Pro Thr Glu Leu Val Cys Asn Arg Thr Phe Asp Lys 
    50                  55                  60                  


Tyr Ser Cys Trp Pro Asp Thr Pro Ala Asn Thr Thr Ala Asn Ile Ser 
65                  70                  75                  80  


Cys Pro Trp Tyr Leu Pro Trp His His Lys Val Gln His Arg Phe Val 
                85                  90                  95      


Phe Lys Arg Cys Gly Pro Asp Gly Gln Trp Val Arg Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Trp Arg Asp Ala Ser Gln Cys Gln Met Asp Gly Glu Glu Ile 
        115                 120                 125             


Glu Val Gln Lys Glu Val Ala Lys Met Tyr Ser Ser Phe Gln Val Met 
    130                 135                 140                 


Tyr Thr Val Gly Tyr Ser Leu Ser Leu Gly Ala Leu Leu Leu Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Gly Gly Leu Ser Lys Leu His Cys Thr Arg Asn Ala Ile 
                165                 170                 175     


His Ala Asn Leu Phe Ala Ser Phe Val Leu Lys Ala Ser Ser Val Leu 
            180                 185                 190         


Val Ile Asp Gly Leu Leu Arg Thr Arg Tyr Ser Gln Lys Ile Gly Asp 
        195                 200                 205             


Asp Leu Ser Val Ser Thr Trp Leu Ser Asp Gly Ala Val Ala Gly Cys 
    210                 215                 220                 


Arg Val Ala Ala Val Phe Met Gln Tyr Gly Ile Val Ala Asn Tyr Cys 
225                 230                 235                 240 


Trp Leu Leu Val Glu Gly Leu Tyr Leu His Asn Leu Leu Gly Leu Ala 
                245                 250                 255     


Thr Leu Pro Glu Arg Ser Phe Phe Ser Leu Tyr Leu Gly Ile Gly Trp 
            260                 265                 270         


Gly Ala Pro Met Leu Phe Val Val Pro Trp Ala Val Val Lys Cys Leu 
        275                 280                 285             


Phe Glu Asn Val Gln Cys Trp Thr Ser Asn Asp Asn Met Gly Phe Trp 
    290                 295                 300                 


Trp Ile Leu Arg Phe Pro Val Phe Leu Ala Ile Leu Ile Asn Phe Phe 
305                 310                 315                 320 


Ile Phe Val Arg Ile Val Gln Leu Leu Val Ala Lys Leu Arg Ala Arg 
                325                 330                 335     


Gln Met His His Thr Asp Tyr Lys Phe Arg Leu Ala Lys Ser Thr Leu 
            340                 345                 350         


Thr Leu Ile Pro Leu Leu Gly Val His Glu Val Val Phe Ala Phe Val 
        355                 360                 365             


Thr Asp Glu His Ala Gln Gly Thr Leu Arg Ser Ala Lys Leu Phe Phe 
    370                 375                 380                 


Asp Leu Phe Leu Ser Ser Phe Gln Gly Leu Leu Val Ala Val Leu Tyr 
385                 390                 395                 400 


Cys Phe Leu Asn Lys Glu Val Gln Ser Glu Leu Arg Arg Arg Trp His 
                405                 410                 415     


Arg Trp Arg Leu Gly Lys Val Leu Trp Glu Glu Arg Asn Thr Ser Asn 
            420                 425                 430         


His Arg Ala Ser Ser Ser Pro Gly His Gly Pro Pro Ser Lys Glu Leu 
        435                 440                 445             


Gln Phe Gly Arg Gly Gly Gly Ser Gln Asp Ser Ser Ala Glu Thr Pro 
    450                 455                 460                 


Leu Ala Gly Gly Leu Pro Arg Leu Ala Glu Ser Pro Phe 
465                 470                 475         


<210>  46
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Gly Ala Pro Gly Pro Leu Arg Leu Ala Leu Leu Leu Leu Gly 
1               5                   10                  15      


Met Val Gly Arg Ala Gly Pro Arg Pro Gln Gly Ala Thr Val Ser Leu 
            20                  25                  30          


Trp Glu Thr Val Gln Lys Trp Arg Glu Tyr Arg Arg Gln Cys Gln Arg 
        35                  40                  45              


Ser Leu Thr Glu Asp Pro Pro Pro Ala Thr Asp Leu Phe Cys Asn Arg 
    50                  55                  60                  


Thr Phe Asp Glu Tyr Ala Cys Trp Pro Asp Gly Glu Pro Gly Ser Phe 
65                  70                  75                  80  


Val Asn Val Ser Cys Pro Trp Tyr Leu Pro Trp Ala Ser Ser Val Pro 
                85                  90                  95      


Gln Gly His Val Tyr Arg Phe Cys Thr Ala Glu Gly Leu Trp Leu Gln 
            100                 105                 110         


Lys Asp Asn Ser Ser Leu Pro Trp Arg Asp Leu Ser Glu Cys Glu Glu 
        115                 120                 125             


Ser Lys Arg Gly Glu Arg Ser Ser Pro Glu Glu Gln Leu Leu Phe Leu 
    130                 135                 140                 


Tyr Ile Ile Tyr Thr Val Gly Tyr Ala Leu Ser Phe Ser Ala Leu Val 
145                 150                 155                 160 


Ile Ala Ser Ala Ile Leu Leu Gly Phe Arg His Leu His Cys Thr Arg 
                165                 170                 175     


Asn Tyr Ile His Leu Asn Leu Phe Ala Ser Phe Ile Leu Arg Ala Leu 
            180                 185                 190         


Ser Val Phe Ile Lys Asp Ala Ala Leu Lys Trp Met Tyr Ser Thr Ala 
        195                 200                 205             


Ala Gln Gln His Gln Trp Asp Gly Leu Leu Ser Tyr Gln Asp Ser Leu 
    210                 215                 220                 


Ser Cys Arg Leu Val Phe Leu Leu Met Gln Tyr Cys Val Ala Ala Asn 
225                 230                 235                 240 


Tyr Tyr Trp Leu Leu Val Glu Gly Val Tyr Leu Tyr Thr Leu Leu Ala 
                245                 250                 255     


Phe Ser Val Leu Ser Glu Gln Trp Ile Phe Arg Leu Tyr Val Ser Ile 
            260                 265                 270         


Gly Trp Gly Val Pro Leu Leu Phe Val Val Pro Trp Gly Ile Val Lys 
        275                 280                 285             


Tyr Leu Tyr Glu Asp Glu Gly Cys Trp Thr Arg Asn Ser Asn Met Asn 
    290                 295                 300                 


Tyr Trp Leu Ile Ile Arg Leu Pro Ile Leu Phe Ala Ile Gly Val Asn 
305                 310                 315                 320 


Phe Leu Ile Phe Val Arg Val Ile Cys Ile Val Val Ser Lys Leu Lys 
                325                 330                 335     


Ala Asn Leu Met Cys Lys Thr Asp Ile Lys Cys Arg Leu Ala Lys Ser 
            340                 345                 350         


Thr Leu Thr Leu Ile Pro Leu Leu Gly Thr His Glu Val Ile Phe Ala 
        355                 360                 365             


Phe Val Met Asp Glu His Ala Arg Gly Thr Leu Arg Phe Ile Lys Leu 
    370                 375                 380                 


Phe Thr Glu Leu Ser Phe Thr Ser Phe Gln Gly Leu Met Val Ala Ile 
385                 390                 395                 400 


Leu Tyr Cys Phe Val Asn Asn Glu Val Gln Leu Glu Phe Arg Lys Ser 
                405                 410                 415     


Trp Glu Arg Trp Arg Leu Glu His Leu His Ile Gln Arg Asp Ser Ser 
            420                 425                 430         


Met Lys Pro Leu Lys Cys Pro Thr Ser Ser Leu Ser Ser Gly Ala Thr 
        435                 440                 445             


Ala Gly Ser Ser Met Tyr Thr Ala Thr Cys Gln Ala Ser Cys Ser 
    450                 455                 460             

