﻿               SEQUENCE LISTING

<110> INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA) 
      INSTITUT D’INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (ID
      IBAPS) 

<120> Diagnostic Method for Detecting an Autoimmune Disease and Related Subject-Matter

<130> 103083PC

<160> 4

<170> BiSSAP 1.0

<210> 1
<211> 801
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..801
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 1
Met Lys Glu Lys Ala Met Ile Lys Thr Ala Lys Met Gln Gly Asn Val 
1               5                   10                   15    
Met Glu Leu Val Gly Ser Asn Pro Pro Gln Arg Asn Trp Lys Gly Ile 
            20                   25                  30        
Ala Ile Ala Leu Leu Val Ile Leu Val Ile Cys Ser Leu Ile Val Thr 
        35                   40                  45            
Ser Val Ile Leu Leu Thr Pro Ala Glu Asp Asn Ser Leu Ser Gln Lys 
    50                   55                  60                
Lys Lys Val Thr Val Glu Asp Leu Phe Ser Glu Asp Phe Lys Ile His 
65                   70                  75                  80
Asp Pro Glu Ala Lys Trp Ile Ser Asp Thr Glu Phe Ile Tyr Arg Glu 
                85                   90                  95    
Gln Lys Gly Thr Val Arg Leu Trp Asn Val Glu Thr Asn Thr Ser Thr 
            100                  105                110        
Val Leu Ile Glu Gly Lys Lys Ile Glu Ser Leu Arg Ala Ile Arg Tyr 
        115                  120                125            
Glu Ile Ser Pro Asp Arg Glu Tyr Ala Leu Phe Ser Tyr Asn Val Glu 
    130                  135                140                
Pro Ile Tyr Gln His Ser Tyr Thr Gly Tyr Tyr Val Leu Ser Lys Ile 
145                  150                155                  160
Pro His Gly Asp Pro Gln Ser Leu Asp Pro Pro Glu Val Ser Asn Ala 
                165                  170                175    
Lys Leu Gln Tyr Ala Gly Trp Gly Pro Lys Gly Gln Gln Leu Ile Phe 
            180                  185                190        
Ile Phe Glu Asn Asn Ile Tyr Tyr Cys Ala His Val Gly Lys Gln Ala 
        195                  200                205            
Ile Arg Val Val Ser Thr Gly Lys Glu Gly Val Ile Tyr Asn Gly Leu 
    210                  215                220                
Ser Asp Trp Leu Tyr Glu Glu Glu Ile Leu Lys Thr His Ile Ala His 
225                  230                235                  240
Trp Trp Ser Pro Asp Gly Thr Arg Leu Ala Tyr Ala Ala Ile Asn Asp 
                245                  250                255    
Ser Arg Val Pro Ile Met Glu Leu Pro Thr Tyr Thr Gly Ser Ile Tyr 
            260                  265                270        
Pro Thr Val Lys Pro Tyr His Tyr Pro Lys Ala Gly Ser Glu Asn Pro 
        275                  280                285            
Ser Ile Ser Leu His Val Ile Gly Leu Asn Gly Pro Thr His Asp Leu 
    290                  295                300                
Glu Met Met Pro Pro Asp Asp Pro Arg Met Arg Glu Tyr Tyr Ile Thr 
305                  310                315                  320
Met Val Lys Trp Ala Thr Ser Thr Lys Val Ala Val Thr Trp Leu Asn 
                325                  330                335    
Arg Ala Gln Asn Val Ser Ile Leu Thr Leu Cys Asp Ala Thr Thr Gly 
            340                  345                350        
Val Cys Thr Lys Lys His Glu Asp Glu Ser Glu Ala Trp Leu His Arg 
        355                  360                365            
Gln Asn Glu Glu Pro Val Phe Ser Lys Asp Gly Arg Lys Phe Phe Phe 
    370                  375                380                
Ile Arg Ala Ile Pro Gln Gly Gly Arg Gly Lys Phe Tyr His Ile Thr 
385                  390                395                  400
Val Ser Ser Ser Gln Pro Asn Ser Ser Asn Asp Asn Ile Gln Ser Ile 
                405                  410                415    
Thr Ser Gly Asp Trp Asp Val Thr Lys Ile Leu Ala Tyr Asp Glu Lys 
            420                  425                430        
Gly Asn Lys Ile Tyr Phe Leu Ser Thr Glu Asp Leu Pro Arg Arg Arg 
        435                  440                445            
Gln Leu Tyr Ser Ala Asn Thr Val Gly Asn Phe Asn Arg Gln Cys Leu 
    450                  455                460                
Ser Cys Asp Leu Val Glu Asn Cys Thr Tyr Phe Ser Ala Ser Phe Ser 
465                  470                475                  480
His Ser Met Asp Phe Phe Leu Leu Lys Cys Glu Gly Pro Gly Val Pro 
                485                  490                495    
Met Val Thr Val His Asn Thr Thr Asp Lys Lys Lys Met Phe Asp Leu 
            500                  505                510        
Glu Thr Asn Glu His Val Lys Lys Ala Ile Asn Asp Arg Gln Met Pro 
        515                  520                525            
Lys Val Glu Tyr Arg Asp Ile Glu Ile Asp Asp Tyr Asn Leu Pro Met 
    530                  535                540                
Gln Ile Leu Lys Pro Ala Thr Phe Thr Asp Thr Thr His Tyr Pro Leu 
545                  550                555                  560
Leu Leu Val Val Asp Gly Thr Pro Gly Ser Gln Ser Val Ala Glu Lys 
                565                  570                575    
Phe Glu Val Ser Trp Glu Thr Val Met Val Ser Ser His Gly Ala Val 
            580                  585                590        
Val Val Lys Cys Asp Gly Arg Gly Ser Gly Phe Gln Gly Thr Lys Leu 
        595                  600                605            
Leu His Glu Val Arg Arg Arg Leu Gly Leu Leu Glu Glu Lys Asp Gln 
    610                  615                620                
Met Glu Ala Val Arg Thr Met Leu Lys Glu Gln Tyr Ile Asp Arg Thr 
625                  630                635                  640
Arg Val Ala Val Phe Gly Lys Asp Tyr Gly Gly Tyr Leu Ser Thr Tyr 
                645                  650                655    
Ile Leu Pro Ala Lys Gly Glu Asn Gln Gly Gln Thr Phe Thr Cys Gly 
            660                  665                670        
Ser Ala Leu Ser Pro Ile Thr Asp Phe Lys Leu Tyr Ala Ser Ala Phe 
        675                  680                685            
Ser Glu Arg Tyr Leu Gly Leu His Gly Leu Asp Asn Arg Ala Tyr Glu 
    690                  695                700                
Met Thr Lys Val Ala His Arg Val Ser Ala Leu Glu Glu Gln Gln Phe 
705                  710                715                  720
Leu Ile Ile His Pro Thr Ala Asp Glu Lys Ile His Phe Gln His Thr 
                725                  730                735    
Ala Glu Leu Ile Thr Gln Leu Ile Arg Gly Lys Ala Asn Tyr Ser Leu 
            740                  745                750        
Gln Ile Tyr Pro Asp Glu Ser His Tyr Phe Thr Ser Ser Ser Leu Lys 
        755                  760                765            
Gln His Leu Tyr Arg Ser Ile Ile Asn Phe Phe Val Glu Cys Phe Arg 
    770                  775                780                
Ile Gln Asp Lys Leu Leu Thr Val Thr Ala Lys Glu Asp Glu Glu Glu 
785                  790                795                  800
Asp 
    

<210> 2
<211> 748
<212> PRT
<213> Rattus norvegicus

<220> 
<221> SOURCE
<222> 1..748
<223> /mol_type="protein"
      /organism="Rattus norvegicus"

<400> 2
Thr Pro Ala Glu Asp Thr Ser Leu Ser Gln Lys Lys Lys Val Thr Val 
1               5                   10                   15    
Glu Asp Leu Phe Ser Glu Asp Phe Lys Ile His Asp Pro Glu Ala Lys 
            20                   25                  30        
Trp Ile Ser Asp Lys Glu Phe Ile Tyr Arg Glu Arg Lys Gly Ser Val 
        35                   40                  45            
Ile Leu Arg Asn Val Glu Thr Asn Asn Ser Thr Val Leu Ile Glu Gly 
    50                   55                  60                
Lys Lys Ile Glu Ser Leu Arg Ala Ile Arg Tyr Glu Ile Ser Pro Asp 
65                   70                  75                  80
Lys Glu Tyr Ala Leu Phe Ser Tyr Asn Val Glu Pro Val Tyr Gln His 
                85                   90                  95    
Ser His Thr Gly Tyr Tyr Val Leu Ser Lys Ile Pro His Gly Asp Pro 
            100                  105                110        
Gln Ser Leu Asp Pro Pro Glu Val Ser Asn Ala Lys Leu Gln Tyr Ala 
        115                  120                125            
Gly Trp Gly Pro Lys Gly Gln Gln Leu Ile Phe Ile Phe Glu Asn Asn 
    130                  135                140                
Ile Tyr Tyr Cys Ala His Val Gly Lys Gln Ala Ile Arg Val Val Ser 
145                  150                155                  160
Thr Gly Lys Glu Gly Val Ile Tyr Asn Gly Leu Ser Asp Trp Leu Tyr 
                165                  170                175    
Glu Glu Glu Ile Leu Lys Ser His Ile Ala His Trp Trp Ser Pro Asp 
            180                  185                190        
Gly Thr Arg Leu Ala Tyr Ala Thr Ile Asn Asp Ser Arg Val Pro Leu 
        195                  200                205            
Met Glu Leu Pro Thr Tyr Thr Gly Ser Val Tyr Pro Thr Val Lys Pro 
    210                  215                220                
Tyr His Tyr Pro Lys Ala Gly Ser Glu Asn Pro Ser Ile Ser Leu His 
225                  230                235                  240
Val Ile Gly Leu Asn Gly Pro Thr His Asp Leu Glu Met Met Pro Pro 
                245                  250                255    
Asp Asp Pro Arg Met Arg Glu Tyr Tyr Ile Thr Met Val Lys Trp Ala 
            260                  265                270        
Thr Ser Thr Lys Val Ala Val Thr Trp Leu Asn Arg Ala Gln Asn Val 
        275                  280                285            
Ser Ile Leu Thr Leu Cys Asp Ala Thr Thr Gly Val Cys Thr Lys Lys 
    290                  295                300                
His Glu Asp Glu Ser Glu Ala Trp Leu His Arg Gln Asn Glu Glu Pro 
305                  310                315                  320
Val Phe Ser Lys Asp Gly Arg Lys Phe Phe Phe Val Arg Ala Ile Pro 
                325                  330                335    
Gln Gly Gly Arg Gly Lys Phe Tyr His Ile Thr Val Ser Ser Ser Gln 
            340                  345                350        
Pro Asn Ser Ser Asn Asp Asn Ile Gln Ser Ile Thr Ser Gly Asp Trp 
        355                  360                365            
Asp Val Thr Glu Ile Leu Thr Tyr Asp Glu Lys Arg Asn Lys Leu Tyr 
    370                  375                380                
Phe Leu Ser Thr Glu Asp Leu Pro Arg Arg Arg His Leu Tyr Ser Ala 
385                  390                395                  400
Asn Thr Val Asp Asp Phe Asn Arg Gln Cys Leu Ser Cys Asp Leu Val 
                405                  410                415    
Glu Asn Cys Thr Tyr Val Ser Ala Ser Phe Ser His Asn Met Asp Phe 
            420                  425                430        
Phe Leu Leu Lys Cys Glu Gly Pro Gly Val Pro Thr Val Thr Val His 
        435                  440                445            
Asn Thr Thr Asp Lys Arg Arg Met Phe Asp Leu Glu Ala Asn Glu Gln 
    450                  455                460                
Val Gln Lys Ala Ile Tyr Asp Arg Gln Met Pro Lys Ile Glu Tyr Arg 
465                  470                475                  480
Lys Ile Glu Val Glu Asp Tyr Ser Leu Pro Met Gln Ile Leu Lys Pro 
                485                  490                495    
Ala Thr Phe Thr Asp Thr Ala His Tyr Pro Leu Leu Leu Val Val Asp 
            500                  505                510        
Gly Thr Pro Gly Ser Gln Ser Val Ser Glu Arg Phe Glu Val Thr Trp 
        515                  520                525            
Glu Thr Val Leu Val Ser Ser His Gly Ala Val Val Val Lys Cys Asp 
    530                  535                540                
Gly Arg Gly Ser Gly Phe Gln Gly Thr Lys Leu Leu His Glu Val Arg 
545                  550                555                  560
Arg Arg Leu Gly Phe Leu Glu Glu Lys Asp Gln Met Glu Ala Val Arg 
                565                  570                575    
Thr Met Leu Lys Glu Gln Tyr Ile Asp Lys Thr Arg Val Ala Val Phe 
            580                  585                590        
Gly Lys Asp Tyr Gly Gly Tyr Leu Ser Thr Tyr Ile Leu Pro Ala Lys 
        595                  600                605            
Gly Glu Asn Gln Gly Gln Thr Phe Thr Cys Gly Ser Ala Leu Ser Pro 
    610                  615                620                
Ile Thr Asp Phe Lys Leu Tyr Ala Ser Ala Phe Ser Glu Arg Tyr Leu 
625                  630                635                  640
Gly Leu His Gly Leu Asp Asn Arg Ala Tyr Glu Met Thr Lys Leu Ala 
                645                  650                655    
His Arg Val Ser Ala Leu Glu Asp Gln Gln Phe Leu Ile Ile His Ala 
            660                  665                670        
Thr Ala Asp Glu Lys Ile His Phe Gln His Thr Ala Glu Leu Ile Thr 
        675                  680                685            
Gln Leu Ile Lys Gly Lys Ala Asn Tyr Ser Leu Gln Ile Tyr Pro Asp 
    690                  695                700                
Glu Ser His Tyr Phe His Ser Val Ala Leu Lys Gln His Leu Tyr Arg 
705                  710                715                  720
Ser Ile Ile Gly Phe Phe Val Glu Cys Phe Arg Ile Gln Asp Lys Leu 
                725                  730                735    
Pro Thr Ala Thr Ala Lys Glu Asp Glu Glu Glu Asp 
            740                  745            

<210> 3
<211> 111
<212> PRT
<213> Rattus norvegicus

<220> 
<221> SOURCE
<222> 1..111
<223> /mol_type="protein"
      /organism="Rattus norvegicus"

<400> 3
Met Ala Ser Leu Tyr Gln Arg Phe Thr Gly Lys Ile Asn Thr Ser Arg 
1               5                   10                   15    
Ser Phe Pro Ala Pro Pro Glu Ala Ser His Leu Leu Gly Gly Gln Gly 
            20                   25                  30        
Pro Glu Glu Asp Ala Gly Ser Lys Pro Leu Gly Pro Gln Ala Gln Ala 
        35                   40                  45            
Val Ala Pro Arg Glu Arg Gly Gly Ala Gly Gly Arg Pro Arg Phe Gln 
    50                   55                  60                
Tyr Gln Ala Arg Ser Asp Cys Asp Glu Glu Asp Glu Leu Val Gly Ser 
65                   70                  75                  80
Asn Pro Pro Gln Arg Asn Trp Lys Gly Ile Ala Ile Ala Leu Leu Val 
                85                   90                  95    
Ile Leu Val Ile Cys Ser Leu Ile Val Thr Ser Val Ile Leu Leu 
            100                  105                110    

<210> 4
<211> 55
<212> PRT
<213> Rattus norvegicus

<220> 
<221> SOURCE
<222> 1..55
<223> /mol_type="protein"
      /organism="Rattus norvegicus"

<400> 4
Met Thr Thr Ala Lys Glu Pro Ser Ala Ser Gly Lys Ser Val Gln Gln 
1               5                   10                   15    
Gln Asp Gln Glu Leu Val Gly Ser Asn Pro Pro Gln Arg Asn Trp Lys 
            20                   25                  30        
Gly Ile Ala Ile Ala Leu Leu Val Ile Leu Val Ile Cys Ser Leu Ile 
        35                   40                  45            
Val Thr Ser Val Ile Leu Leu 
    50                   55

