                         SEQUENCE LISTING

<110>  VIB VZW
       VRIJE UNIVERSITEIT BRUSSEL
 
<120>  Immunoglobulin single variable domains directed against CD74 and 
       uses derived thereof

<130>  PaDB/MIF/430

<150>  US 61/696,644
<151>  2012-09-04

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
    210                 215                 220                 


Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
225                 230                 235                 240 


Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                245                 250                 255     


Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
            260                 265                 270         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        275                 280                 285             


Gln Asp Leu Gly Pro Val Pro Met 
    290                 295     


<210>  2
<211>  169
<212>  PRT
<213>  artificial

<220>
<223>  Recombinant human CD74 including N-terminal hemagglutinin tag

<400>  2

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gln Gln Gln Gly Arg Leu Asp 
1               5                   10                  15      


Lys Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met 
            20                  25                  30          


Lys Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr 
        35                  40                  45              


Pro Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro 
    50                  55                  60                  


Met Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met 
65                  70                  75                  80  


His Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys 
                85                  90                  95      


Gly Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr 
            100                 105                 110         


Ile Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe 
        115                 120                 125             


Glu Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro 
    130                 135                 140                 


Lys Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr 
145                 150                 155                 160 


Lys Gln Asp Leu Gly Pro Val Pro Met 
                165                 


<210>  3
<211>  166
<212>  PRT
<213>  artificial

<220>
<223>  Recombinant human CD74 fused with a polyhistidine tag at the N 
       -terminus

<400>  3

His His His His His His Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr 
1               5                   10                  15      


Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys Leu Pro 
            20                  25                  30          


Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro Leu Leu 
        35                  40                  45              


Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met Gln Asn 
    50                  55                  60                  


Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His Leu Leu 
65                  70                  75                  80  


Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe 
                85                  90                  95      


Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile Asp Trp 
            100                 105                 110         


Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu Met Ser 
        115                 120                 125             


Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys Glu Ser 
    130                 135                 140                 


Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys Gln Asp 
145                 150                 155                 160 


Leu Gly Pro Val Pro Met 
                165     


<210>  4
<211>  279
<212>  PRT
<213>  Mus musculus

<400>  4

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                  15      


Leu Gly Asn Arg Pro Arg Glu Pro Glu Arg Cys Ser Arg Gly Ala Leu 
            20                  25                  30          


Tyr Thr Gly Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala 
        35                  40                  45              


Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu 
    50                  55                  60                  


Thr Ile Thr Ser Gln Asn Leu Gln Leu Glu Ser Leu Arg Met Lys Leu 
65                  70                  75                  80  


Pro Lys Ser Ala Lys Pro Val Ser Gln Met Arg Met Ala Thr Pro Leu 
                85                  90                  95      


Leu Met Arg Pro Met Ser Met Asp Asn Met Leu Leu Gly Pro Val Lys 
            100                 105                 110         


Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His Leu 
        115                 120                 125             


Leu Thr Arg Ser Gly Pro Leu Glu Tyr Pro Gln Leu Lys Gly Thr Phe 
    130                 135                 140                 


Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asp Gly Val Asn Trp 
145                 150                 155                 160 


Lys Ile Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met Ser 
                165                 170                 175     


Lys Asn Ser Leu Glu Glu Lys Lys Pro Thr Glu Ala Pro Pro Lys Val 
            180                 185                 190         


Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val Tyr Pro 
        195                 200                 205             


Gly Ala Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro Leu 
    210                 215                 220                 


Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Phe Pro Asn Gly 
225                 230                 235                 240 


Thr Glu Val Pro His Thr Lys Ser Arg Gly Arg His Asn Cys Ser Glu 
                245                 250                 255     


Pro Leu Asp Met Glu Asp Leu Ser Ser Gly Leu Gly Val Thr Arg Gln 
            260                 265                 270         


Glu Leu Gly Gln Val Thr Leu 
        275                 


<210>  5
<211>  169
<212>  PRT
<213>  artificial

<220>
<223>  Recombinant mouse CD74 with an N-terminal HA-tag

<400>  5

Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Ile Thr Ser Gln Asn Leu 
1               5                   10                  15      


Gln Leu Glu Ser Leu Arg Met Lys Leu Pro Lys Ser Ala Lys Pro Val 
            20                  25                  30          


Ser Gln Met Arg Met Ala Thr Pro Leu Leu Met Arg Pro Met Ser Met 
        35                  40                  45              


Asp Asn Met Leu Leu Gly Pro Val Lys Asn Val Thr Lys Tyr Gly Asn 
    50                  55                  60                  


Met Thr Gln Asp His Val Met His Leu Leu Thr Arg Ser Gly Pro Leu 
65                  70                  75                  80  


Glu Tyr Pro Gln Leu Lys Gly Thr Phe Pro Glu Asn Leu Lys His Leu 
                85                  90                  95      


Lys Asn Ser Met Asp Gly Val Asn Trp Lys Ile Phe Glu Ser Trp Met 
            100                 105                 110         


Lys Gln Trp Leu Leu Phe Glu Met Ser Lys Asn Ser Leu Glu Glu Lys 
        115                 120                 125             


Lys Pro Thr Glu Ala Pro Pro Lys Glu Pro Leu Asp Met Glu Asp Leu 
    130                 135                 140                 


Ser Ser Gly Leu Gly Val Thr Arg Gln Glu Leu Gly Gln Val Thr Leu 
145                 150                 155                 160 


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                165                 


<210>  6
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Val Thr Ser Gln Asn Leu 
1               5                   10                  15      


Gln Leu Glu Asn Leu Arg Met Lys Leu Pro Lys Pro Pro Lys Pro Val 
            20                  25                  30          


Ser Lys Met Arg Met Ala Thr Pro Leu Leu Met Gln Ala Leu Pro Met 
        35                  40                  45              


Gly Ala Leu Pro Gln Gly Pro Met Gln Asn Ala Thr Lys Tyr Gly Asn 
    50                  55                  60                  


Met Thr Glu Asp His Val Met His Leu Leu Gln Asn Ala Asp Pro Leu 
65                  70                  75                  80  


Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe Pro Glu Asn Leu Arg His 
                85                  90                  95      


Leu Lys Asn Thr Met Glu Thr Ile Asp Trp Lys Val Phe Glu Ser Trp 
            100                 105                 110         


Met His His Trp Leu Leu Phe Glu Met Ser Arg His Ser Leu Glu Gln 
        115                 120                 125             


Lys Pro Thr Asp Ala Pro Pro Lys Val Leu Thr Lys Cys Gln Glu Glu 
    130                 135                 140                 


Val Ser His Ile Pro Ala Val His Pro Gly Ser Phe Arg Pro Lys Cys 
145                 150                 155                 160 


Asp Glu Asn Gly Asn Tyr Leu Pro Leu Gln Cys Tyr Gly Ser Ile Gly 
                165                 170                 175     


Tyr Cys Trp Cys Val Phe Pro Asn Gly Thr Glu Val Pro Asn Thr Arg 
            180                 185                 190         


Ser Arg Gly His His Asn Cys Ser Glu Ser Leu Glu Leu Glu Asp Pro 
        195                 200                 205             


Ser Ser Gly Leu Gly Val Thr Lys Gln Asp Leu Gly Pro Val Pro Met 
    210                 215                 220                 


<210>  7
<211>  224
<212>  PRT
<213>  Mus musculus

<400>  7

Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Ile Thr Ser Gln Asn Leu 
1               5                   10                  15      


Gln Leu Glu Ser Leu Arg Met Lys Leu Pro Lys Ser Ala Lys Pro Val 
            20                  25                  30          


Ser Gln Met Arg Met Ala Thr Pro Leu Leu Met Arg Pro Met Ser Met 
        35                  40                  45              


Asp Asn Met Leu Leu Gly Pro Val Lys Asn Val Thr Lys Tyr Gly Asn 
    50                  55                  60                  


Met Thr Gln Asp His Val Met His Leu Leu Thr Arg Ser Gly Pro Leu 
65                  70                  75                  80  


Glu Tyr Pro Gln Leu Lys Gly Thr Phe Pro Glu Asn Leu Lys His Leu 
                85                  90                  95      


Lys Asn Ser Met Asp Gly Val Asn Trp Lys Ile Phe Glu Ser Trp Met 
            100                 105                 110         


Lys Gln Trp Leu Leu Phe Glu Met Ser Lys Asn Ser Leu Glu Glu Lys 
        115                 120                 125             


Lys Pro Thr Glu Ala Pro Pro Lys Val Leu Thr Lys Cys Gln Glu Glu 
    130                 135                 140                 


Val Ser His Ile Pro Ala Val Tyr Pro Gly Ala Phe Arg Pro Lys Cys 
145                 150                 155                 160 


Asp Glu Asn Gly Asn Tyr Leu Pro Leu Gln Cys His Gly Ser Thr Gly 
                165                 170                 175     


Tyr Cys Trp Cys Val Phe Pro Asn Gly Thr Glu Val Pro His Thr Lys 
            180                 185                 190         


Ser Arg Gly Arg His Asn Cys Ser Glu Pro Leu Asp Met Glu Asp Leu 
        195                 200                 205             


Ser Ser Gly Leu Gly Val Thr Arg Gln Glu Leu Gly Gln Val Thr Leu 
    210                 215                 220                 


<210>  8
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro 
1               5                   10                  15      


Asp Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly 
            20                  25                  30          


Lys Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met 
        35                  40                  45              


Ala Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser 
    50                  55                  60                  


Ile Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu 
65                  70                  75                  80  


Cys Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr 
                85                  90                  95      


Ile Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser 
            100                 105                 110         


Thr Phe Ala 
        115 


<210>  9
<211>  114
<212>  PRT
<213>  artificial

<220>
<223>  Recombinant human MIF

<400>  9

Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Asp 
1               5                   10                  15      


Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly Lys 
            20                  25                  30          


Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met Ala 
        35                  40                  45              


Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser Ile 
    50                  55                  60                  


Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu Cys 
65                  70                  75                  80  


Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr Ile 
                85                  90                  95      


Asn Tyr Tyr Asp Met Asn Ala Ala Ser Val Gly Trp Asn Asn Ser Thr 
            100                 105                 110         


Phe Ala 
        


<210>  10
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Phe Leu Glu Leu Asp Thr Asn Leu Pro Ala Asn Arg Val Pro 
1               5                   10                  15      


Ala Gly Leu Glu Lys Arg Leu Cys Ala Ala Ala Ala Ser Ile Leu Gly 
            20                  25                  30          


Lys Pro Ala Asp Arg Val Asn Val Thr Val Arg Pro Gly Leu Ala Met 
        35                  40                  45              


Ala Leu Ser Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser 
    50                  55                  60                  


Ile Gly Val Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His 
65                  70                  75                  80  


Phe Phe Glu Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Ile 
                85                  90                  95      


Leu Ile Arg Phe Phe Pro Leu Glu Ser Trp Gln Ile Gly Lys Ile Gly 
            100                 105                 110         


Thr Val Met Thr Phe Leu 
        115             


<210>  11
<211>  138
<212>  PRT
<213>  artificial

<220>
<223>  Human MIF2 D-Dopachrome Tautomerase (D-DT) including a 20 aa 
       N-terminal Histidine Tag

<400>  11

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Pro Phe Leu Glu Leu Asp Thr Asn Leu Pro Ala 
            20                  25                  30          


Asn Arg Val Pro Ala Gly Leu Glu Lys Arg Leu Cys Ala Ala Ala Ala 
        35                  40                  45              


Ser Ile Leu Gly Lys Pro Ala Asp Arg Val Asn Val Thr Val Arg Pro 
    50                  55                  60                  


Gly Leu Ala Met Ala Leu Ser Gly Ser Thr Glu Pro Cys Ala Gln Leu 
65                  70                  75                  80  


Ser Ile Ser Ser Ile Gly Val Val Gly Thr Ala Glu Asp Asn Arg Ser 
                85                  90                  95      


His Ser Ala His Phe Phe Glu Phe Leu Thr Lys Glu Leu Ala Leu Gly 
            100                 105                 110         


Gln Asp Arg Ile Leu Ile Arg Phe Phe Pro Leu Glu Ser Trp Gln Ile 
        115                 120                 125             


Gly Lys Ile Gly Thr Val Met Thr Phe Leu 
    130                 135             


<210>  12
<211>  119
<212>  PRT
<213>  Vicugna pacos

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Val Tyr Ser Leu Lys 
            20                  25                  30          


Ala Tyr Asp Trp Gly Trp Ala Arg Gln Ala Pro Gly Lys Glu Cys Glu 
        35                  40                  45              


Leu Val Gly Arg Ile Met Pro Asn Gly Ala Thr Val Tyr Ile Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Ile Ile Ser Arg Glu Asn Ser Asn Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Gly Asp Pro Ser Gly Gly Trp Cys Lys Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  13
<211>  119
<212>  PRT
<213>  Vicugna pacos

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Val Tyr Ser Leu Lys 
            20                  25                  30          


Ala Tyr Asp Trp Gly Trp Ala Arg Gln Ala Pro Gly Lys Glu Cys Glu 
        35                  40                  45              


Leu Val Gly Arg Ile Met Pro Asn Gly Ala Thr Val Tyr Ile Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Ile Ile Ser Arg Glu Asn Ser Asn Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Gly Asp Pro Ser Gly Gly Trp Cys Lys Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  120
<212>  PRT
<213>  Vicugna pacos

<400>  14

Gln Val Gln Leu Gln Glu Leu Gly Glu Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ser Ile Asn 
            20                  25                  30          


Ser Met Ala Trp Tyr Arg Gln Pro Ser Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Phe Thr Arg Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Glu Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Phe 
                85                  90                  95      


Val Asp Trp Ser Asp Ser Asp Asp Ser Glu Tyr Glu Asp Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  121
<212>  PRT
<213>  Vicugna pacos

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Ala Tyr Ser Asp Tyr Asp Pro Gln Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  113
<212>  PRT
<213>  Vicugna pacos

<400>  16

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Gly Gly Gly Gly Ser Ala Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Phe Ala Trp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  17
<211>  114
<212>  PRT
<213>  Vicugna pacos

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Ala Thr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Gln Asp Trp His Tyr Trp Gly Lys Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  18
<211>  131
<212>  PRT
<213>  Vicugna pacos

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Asp Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Leu Glu Leu Pro Gly Ile Lys Trp Gly Ala Glu Thr Arg Trp 
            100                 105                 110         


Asp Arg Trp Ala Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  19
<211>  115
<212>  PRT
<213>  Vicugna pacos

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Ser Tyr Thr Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Gly Glu Asp Phe Ser Ser Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  20
<211>  112
<212>  PRT
<213>  Vicugna pacos

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Val Asn Gly Gly Gly Ser Ala Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Val Ala Trp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  21
<211>  115
<212>  PRT
<213>  Vicugna pacos

<400>  21

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Ser Tyr Ser Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Gly Glu Asp Phe Ser Ser Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  22
<211>  253
<212>  PRT
<213>  Vicugna pacos

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Val Tyr Ser Leu Lys 
            20                  25                  30          


Ala Tyr Asp Trp Gly Trp Ala Arg Gln Ala Pro Gly Lys Glu Cys Glu 
        35                  40                  45              


Leu Val Gly Arg Ile Met Pro Asn Gly Ala Thr Val Tyr Ile Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Ile Ile Ser Arg Glu Asn Ser Asn Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Gly Asp Pro Ser Gly Gly Trp Cys Lys Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
    130                 135                 140                 


Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly 
145                 150                 155                 160 


Leu Val Tyr Ser Leu Lys Ala Tyr Asp Trp Gly Trp Ala Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Glu Cys Glu Leu Val Gly Arg Ile Met Pro Asn Gly Ala 
            180                 185                 190         


Thr Val Tyr Ile Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Glu 
        195                 200                 205             


Asn Ser Asn Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Phe Glu 
    210                 215                 220                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Gly Asp Pro Ser Gly Gly 
225                 230                 235                 240 


Trp Cys Lys Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250             


<210>  23
<211>  258
<212>  PRT
<213>  Vicugna pacos

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Val Tyr Ser Leu Lys 
            20                  25                  30          


Ala Tyr Asp Trp Gly Trp Ala Arg Gln Ala Pro Gly Lys Glu Cys Glu 
        35                  40                  45              


Leu Val Gly Arg Ile Met Pro Asn Gly Ala Thr Val Tyr Ile Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Ile Ile Ser Arg Glu Asn Ser Asn Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Gly Asp Pro Ser Gly Gly Trp Cys Lys Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Arg Asn Ile Ser Glu Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Ala Gly Asn Ile 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Asn Thr Val His Leu Gln Met Asn Thr Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala Gly Arg Tyr Ser Ala Trp Tyr Val 
225                 230                 235                 240 


Ala Ala Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  24
<211>  258
<212>  PRT
<213>  Vicugna pacos

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Val Tyr Ser Leu Lys 
            20                  25                  30          


Ala Tyr Asp Trp Gly Trp Ala Arg Gln Ala Pro Gly Lys Glu Cys Glu 
        35                  40                  45              


Leu Val Gly Arg Ile Met Pro Asn Gly Ala Thr Val Tyr Ile Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Ile Ile Ser Arg Glu Asn Ser Asn Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Gly Asp Pro Ser Gly Gly Trp Cys Lys Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Arg Asn Ile Ser Glu Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Ser His Asn Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Asn Thr Val His Leu Gln Met Asn Thr Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala Gly Arg Tyr Ser Ala Trp Tyr Val 
225                 230                 235                 240 


Ala Ala Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  25
<211>  357
<212>  DNA
<213>  Vicugna pacos

<400>  25
caggtgcagc tgcaggagtc tgggggaggc tcggtacagg ctggagggtc tctgagactc       60

tcctgtgtcg cctctggatt agtctacagc ctcaaagcct atgactgggg ctgggcccgt      120

caggctccgg ggaaggagtg cgaattggtc ggcagaatta tgcctaatgg tgcgacagtc      180

tatatcgact ccgtaaaggg ccgattcatt atctcccggg agaattccaa caacacggtg      240

tatctacaaa tgaatagcct gaaatttgag gacacggccg tgtattactg tgcgcgcgta      300

ggtgacccca gtggtggctg gtgcaagggc caggggaccc aggtcaccgt ctcctca         357


<210>  26
<211>  357
<212>  DNA
<213>  Vicugna pacos

<400>  26
caggtgcagc tgcaggagtc tgggggaggc tcggtacagg ctggagggtc tctgagactc       60

tcctgtgtcg cctctggatt agtctacagc ctcaaagcct atgactgggg ctgggcccgt      120

caggctccgg ggaaggagtg cgaattggtc ggcagaatta tgcctaatgg tgcgacagtc      180

tatatcgact ccgtaaaggg ccgattcatt atctcccggg agaactccaa caacacggtg      240

tatctacaaa tgaatagcct gaaatttgag gacacggccg tgtattactg tgcgcgcgta      300

ggcgacccca gtggtggctg gtgcaagggc caggggaccc aggtcaccgt ctcctca         357


<210>  27
<211>  360
<212>  DNA
<213>  Vicugna pacos

<400>  27
caggtgcagc tgcaggagtt gggggaggct ctggtgcagc ctggggggtc catgagactc       60

tcctgtgcag cctctggaaa tatcttcagt atcaattcca tggcctggta ccgccagcct      120

tcagggaagc ggcgcgagtt ggtcgcagca tttactcgcg gtggtaatat aaactatgca      180

gactccgtga aggagcgatt caccatctcc agagacaacg ccaagaacac gatgtatctg      240

caaatgaaca acctgaaacc cgaggatacg gccgtctatt attgttttgt agattggagt      300

gactccgacg attctgagta tgaggactgg ggccagggga cccaggtcac cgtctcctca      360


<210>  28
<211>  25
<212>  PRT
<213>  Vicugna pacos

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  29
<211>  25
<212>  PRT
<213>  Vicugna pacos

<400>  29

Gln Val Gln Leu Gln Glu Leu Gly Glu Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  30
<211>  25
<212>  PRT
<213>  Vicugna pacos

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  31
<211>  25
<212>  PRT
<213>  Vicugna pacos

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  32
<211>  25
<212>  PRT
<213>  Vicugna pacos

<400>  32

Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  33
<211>  25
<212>  PRT
<213>  Vicugna pacos

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Asp Ser 
            20                  25  


<210>  34
<211>  25
<212>  PRT
<213>  Vicugna pacos

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  35
<211>  25
<212>  PRT
<213>  Vicugna pacos

<400>  35

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  36
<211>  25
<212>  PRT
<213>  Vicugna pacos

<400>  36

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  37
<211>  10
<212>  PRT
<213>  Vicugna pacos

<400>  37

Gly Leu Val Tyr Ser Leu Lys Ala Tyr Asp 
1               5                   10  


<210>  38
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  38

Gly Asn Ile Phe Ser Ile Asn Ser 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  39

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  40

Gly Phe Thr Phe Ser Ser Tyr Arg 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  41

Gly Phe Ser Phe Ser Ser Tyr Phe 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  42

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  43

Gly Phe Thr Phe Ser Ser Ser Ala 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  44

Gly Phe Thr Phe Ser Ser Tyr Val 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  45

Gly Phe Thr Phe Ser Ser Ser Val 
1               5               


<210>  46
<211>  17
<212>  PRT
<213>  Vicugna pacos

<400>  46

Trp Gly Trp Ala Arg Gln Ala Pro Gly Lys Glu Cys Glu Leu Val Gly 
1               5                   10                  15      


Arg 
    


<210>  47
<211>  17
<212>  PRT
<213>  Vicugna pacos

<400>  47

Met Ala Trp Tyr Arg Gln Pro Ser Gly Lys Arg Arg Glu Leu Val Ala 
1               5                   10                  15      


Ala 
    


<210>  48
<211>  17
<212>  PRT
<213>  Vicugna pacos

<400>  48

Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  17
<212>  PRT
<213>  Vicugna pacos

<400>  49

Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser 
1               5                   10                  15      


Ala 
    


<210>  50
<211>  17
<212>  PRT
<213>  Vicugna pacos

<400>  50

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Ser 
    


<210>  51
<211>  17
<212>  PRT
<213>  Vicugna pacos

<400>  51

Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  15      


Cys 
    


<210>  52
<211>  17
<212>  PRT
<213>  Vicugna pacos

<400>  52

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Ser 
    


<210>  53
<211>  17
<212>  PRT
<213>  Vicugna pacos

<400>  53

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser 
1               5                   10                  15      


Ala 
    


<210>  54
<211>  18
<212>  PRT
<213>  Vicugna pacos

<400>  54

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Ser Ile 
        


<210>  55
<211>  7
<212>  PRT
<213>  Vicugna pacos

<400>  55

Ile Met Pro Asn Gly Ala Thr 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Vicugna pacos

<400>  56

Phe Thr Arg Gly Gly Asn Ile 
1               5           


<210>  57
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  57

Ile Asn Thr Gly Gly Gly Ser Thr 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  58

Ile Asn Gly Gly Gly Gly Ser Ala 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  59

Ile Asn Ser Gly Gly Gly Ser Thr 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  60

Ile Ser Ser Ser Asp Gly Ser Thr 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  61

Ile Tyr Ser Tyr Thr Ser Asn Thr 
1               5               


<210>  62
<211>  7
<212>  PRT
<213>  Vicugna pacos

<400>  62

Val Asn Gly Gly Gly Ser Ala 
1               5           


<210>  63
<211>  7
<212>  PRT
<213>  Vicugna pacos

<400>  63

Tyr Ser Tyr Ser Tyr Asn Thr 
1               5           


<210>  64
<211>  38
<212>  PRT
<213>  Vicugna pacos

<400>  64

Val Tyr Ile Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Glu Asn 
1               5                   10                  15      


Ser Asn Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Phe Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  65
<211>  38
<212>  PRT
<213>  Vicugna pacos

<400>  65

Asn Tyr Ala Asp Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Met Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  66
<211>  38
<212>  PRT
<213>  Vicugna pacos

<400>  66

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  67
<211>  38
<212>  PRT
<213>  Vicugna pacos

<400>  67

Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Val Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  68
<211>  38
<212>  PRT
<213>  Vicugna pacos

<400>  68

Tyr Tyr Ala Thr Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  69
<211>  38
<212>  PRT
<213>  Vicugna pacos

<400>  69

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  70
<211>  38
<212>  PRT
<213>  Vicugna pacos

<400>  70

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  71
<211>  38
<212>  PRT
<213>  Vicugna pacos

<400>  71

Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Val Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  72
<211>  38
<212>  PRT
<213>  Vicugna pacos

<400>  72

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  73
<211>  11
<212>  PRT
<213>  Vicugna pacos

<400>  73

Ala Arg Val Gly Asp Pro Ser Gly Gly Trp Cys 
1               5                   10      


<210>  74
<211>  14
<212>  PRT
<213>  Vicugna pacos

<400>  74

Phe Val Asp Trp Ser Asp Ser Asp Asp Ser Glu Tyr Glu Asp 
1               5                   10                  


<210>  75
<211>  14
<212>  PRT
<213>  Vicugna pacos

<400>  75

Ala Thr Trp Ala Tyr Ser Asp Tyr Asp Pro Gln Tyr Asp Tyr 
1               5                   10                  


<210>  76
<211>  6
<212>  PRT
<213>  Vicugna pacos

<400>  76

Ala Thr Phe Ala Trp Asn 
1               5       


<210>  77
<211>  7
<212>  PRT
<213>  Vicugna pacos

<400>  77

Thr Ser Gln Asp Trp His Tyr 
1               5           


<210>  78
<211>  24
<212>  PRT
<213>  Vicugna pacos

<400>  78

Ala Ala Leu Glu Leu Pro Gly Ile Lys Trp Gly Ala Glu Thr Arg Trp 
1               5                   10                  15      


Asp Arg Trp Ala Glu Tyr Asp Tyr 
            20                  


<210>  79
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  79

Ala Tyr Gly Glu Asp Phe Ser Ser 
1               5               


<210>  80
<211>  6
<212>  PRT
<213>  Vicugna pacos

<400>  80

Ala Thr Val Ala Trp Asn 
1               5       


<210>  81
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  81

Ala Tyr Gly Glu Asp Phe Ser Ser 
1               5               


<210>  82
<211>  24
<212>  PRT
<213>  Vicugna pacos

<400>  82

Lys Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr Pro 
1               5                   10                  15      


Tyr Asp Val Pro Asp Tyr Gly Ser 
            20                  


<210>  83
<211>  11
<212>  PRT
<213>  Vicugna pacos

<400>  83

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  84
<211>  11
<212>  PRT
<213>  Vicugna pacos

<400>  84

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  85
<211>  11
<212>  PRT
<213>  Vicugna pacos

<400>  85

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  86
<211>  11
<212>  PRT
<213>  Vicugna pacos

<400>  86

Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  87
<211>  11
<212>  PRT
<213>  Vicugna pacos

<400>  87

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  88
<211>  11
<212>  PRT
<213>  Vicugna pacos

<400>  88

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  89
<211>  11
<212>  PRT
<213>  Vicugna pacos

<400>  89

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  90
<211>  11
<212>  PRT
<213>  Vicugna pacos

<400>  90

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  91

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  92
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  92

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  93

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  94

Ala His His Ser Glu Asp Pro Ser Ser Lys Ala Pro Lys Ala Pro Met 
1               5                   10                  15      


Ala 
    


<210>  95
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  95

Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser 
1               5                   10                  15      


<210>  96
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Factor Xa cleavage site

<400>  96

Ile Glu Gly Arg 
1               


<210>  97
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thrombin cleavage site

<400>  97

Leu Val Pro Arg 
1               


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enterokinase cleaving site

<400>  98

Asp Asp Asp Asp Lys 
1               5   


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PreScission cleavage site

<400>  99

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  100
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  100
cagctgcagg agttggggga ggctctggtg cagcctgggg                             40


<210>  101
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  101
ttcccagtca cgac                                                         14


<210>  102
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  102
ctgtgcgcgc gtaggcgacc ccagtggtgg c                                      31


<210>  103
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  103
gccaccactg gggtcgccta cgcgcgcaca g                                      31


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  104
cacacaggaa acagctatga c                                                 21


<210>  105
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  105
tatctcccgg gagaactcca acaacacggt g                                      31


<210>  106
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  106
caccgtgttg ttggagttct cccgggagat a                                      31


<210>  107
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  107
taccatggcc caggtgcagc ttcaggagtc yggrggagg                              39


<210>  108
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  108
attcctgcag ctgcacctga ctaccgccgc ctccggaacc tccaccgccg gatccgcctc       60

cgcctgagga gaccgtgacc tgggtbcc                                          88


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  109

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


