                         SEQUENCE LISTING

<110>  Merial Limited
       Fischer, Laurent
       Carboulec, Nicolas
       Lux, Fabien

<120>  CHIMERIC KSAC PROTEIN AND USES THEREOF

<130>  MER 12-196

<150>  61/694,968
<151>  2012-08-30

<150>  61/830,425 
<151>  2013-06-03

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  3012
<212>  DNA
<213>  artificial sequence

<220>
<223>  KSAC DNA

<400>  1
atggccacca cgtacgagga gttttcggcg aagctggacc gcctggatga ggagttcaac       60

aggaagatgc aggagcagaa cgccaagttc tttgcggaca agccggatga gtcgacgctg      120

tcgcccgaga tgaaggagca ctacgagaag ttcgagcgca tgatcaagga acacacagag      180

aagttcaaca agaagatgca cgagcactcg gagcacttca agcagaagtt cgccgagctg      240

ctcgagcagc agaaggctgc gcagtacccg tccaagacta gttccgccgg tggccgtgag      300

accgcgccga cgaacctgat tcgtcgccgc aacaaggacg agacaaacgg ggatgtcagc      360

gccgccgccg accgcttccg cgaccgcttc gagaaggcaa ccctcgagga gcgcaaggcc      420

gccaccacga cgatggtcaa cgagtactac gacctggtga cggacttcta cgagtacggc      480

tggggccaga acttccattt cgcgccgcgc tacgccggcg agaccttctt cgagtccctc      540

gcgcgccacg agtacttcct ggccgctcgc ggcggcttca tggagggcga ccacatcgtc      600

gacgtgggct gcggcgtcgg cggtccggcg cgcaacatgg ttcgcctcac gcgctgcaac      660

gtcatcggcg tcaacaacaa cgattaccag atcagccgcg ctcgccgtca tgacgcgctc      720

gccggtatga gctccaagat cgactacgtc aagaccgact tctgcaacat gagcttagcc      780

gacaacacct tcgacggcgc ctacgccatc gaggccacct gccacgcaaa ggacaaggtc      840

aagtgctata gcgaggtctt ccgtgtcatc aagcccggca cctgctttgt cctgtacgag      900

tggtgcatga ccgacaagta caaccccaat gacgagtacc accgcacaat caagcaccgc      960

atcgagctgg gcgacggcct gccggagatg gagacgtgca aacaggtgat cgagtacatg     1020

aagcaggccg gcttcgtggt ggaggaggcc atagacgtca tcagtcagtt cgagtccagc     1080

cccatcaaga gtatcccgtg gtaccagccg ctggtcggcg actattcgtc cctgcagggc     1140

ctgcgctcta ccccgattgg ccgcatcctc acgaacgtca tgtgtcgcgt gctggagttc     1200

gtgcgcctag ctccgaaggg cacgtacaag gcgacggaga ttttggagga ggctgcggaa     1260

agcctggtgg tgggcggtca gctcggcatc ttcacgccgt ccttctacat ccgcgctcgc     1320

aagccgtcca agcaggctgg atccaagatc cgcagcgtgc gtccgcttgt ggtgttgctg     1380

gtgtgcgtcg cggcggtgct cgcactcagc gcctccgctg agccgcacaa ggcggccgtt     1440

gacgtcggcc cgctgagcgt tggcccgcag agcgtcggcc cgctgagcgt tggcccgcag     1500

gcggttggcc cgctgagcgt tggcccgcag agcgtcggcc cgctgagcgt tggcccgcag     1560

gcggttggcc cgctgagcgt tggcccgcag agcgttggcc cgctgagcgt tggcccgctg     1620

agcgttggcc cgcagagcgt tggcccgctg agcgttggca gccagagcgt cggcccgctg     1680

agcgttggtc cgcagagcgt cggcccgctg agcgttggcc cgcaggcggt tggcccgctg     1740

agcgttggcc cgcagagcgt cggcccgctg agcgttggcc cgcaggcggt tggcccgctg     1800

agcgttggcc cgcagagcgt tggcccgctg agcgttggcc cgcagagcgt tggcccgctg     1860

agcgttggca gccagagcgt cggcccgctg agcgttggtc cgcagagcgt cggcccgctg     1920

agcgttggcc cgcagagcgt cggcccgctg agcgttggcc cgcagagcgt cggcccgctg     1980

agcgttggtc cgcagagcgt tggcccgctg agcgttggcc cgcagagcgt tgacgttagc     2040

ccggtgagcg gatccgaatt cgatgcggtg gactggcgcg agaagggcgc cgtgacgccg     2100

gtgaagaatc aaggcgcgtg cgggtcgtgc tgggcgttct cggcggtcgg caacatcgag     2160

tcgcagtggg cccgtgccgg ccacggcttg gtgagcctgt cggagcagca gctggtgagc     2220

tgcgatgaca aagacaatgg ctgcaacggc gggctgatgc tgcaggcgtt cgagtggctg     2280

ctgcgacaca tgtacgggat cgtgttcacg gagaagagct acccctacac gtccggcaac     2340

ggtgatgtgg ccgagtgctt gaacagcagt aaactcgttc ccggcgcgca aatcgacggc     2400

tacgtgatga tcccgagcaa cgaaacggtt atggctgcgt ggcttgcgga gaatggcccc     2460

atcgcgattg cggtcgacgc cagctccttc atgtcttacc agagcggcgt gctgaccagc     2520

tgcgctggcg atgcactgaa ccacggcgtg ctgctcgtcg ggtacaacaa gaccggtggg     2580

gttccgtact gggtgatcaa gaactcgtgg ggtgaggact ggggcgagaa gggctacgtg     2640

cgcgtggtca tggggctgaa cgcgtgcctg ctcagtgaat accccgtgtc cgcgcatgtg     2700

ccgcggagtc tcacccctgg cccgggcacg gagagcgagg agcgcgcccc taaacgggtg     2760

acggtggagc agatgatgtg caccgatatg tactgcaggg aggggtgcaa gaagagtctt     2820

ctcaccgcga acgtgtgcta caagaacggg ggaggcggct cctctatgac gaagtgcggt     2880

ccgcagaagg tgctgatgtg ctcgtactcg aaccctcatt gctttggtcc tgggctgtgc     2940

ctcgagactc ctgatggcaa gtgcgcgccg tacttcttgg gctcgatcat gaacacctgc     3000

cagtacacgt aa                                                         3012


<210>  2
<211>  1003
<212>  PRT
<213>  artificial sequence

<220>
<223>  KSAC protein

<400>  2

Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp 
1               5                   10                  15      


Glu Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala 
            20                  25                  30          


Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr 
        35                  40                  45              


Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys 
    50                  55                  60                  


Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu 
65                  70                  75                  80  


Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys Thr Ser Ser Ala 
                85                  90                  95      


Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys 
            100                 105                 110         


Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp 
        115                 120                 125             


Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr 
    130                 135                 140                 


Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly 
145                 150                 155                 160 


Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe 
                165                 170                 175     


Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly 
            180                 185                 190         


Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly Val Gly Gly 
        195                 200                 205             


Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val 
    210                 215                 220                 


Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu 
225                 230                 235                 240 


Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn 
                245                 250                 255     


Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala 
            260                 265                 270         


Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg 
        275                 280                 285             


Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr 
    290                 295                 300                 


Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg 
305                 310                 315                 320 


Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val 
                325                 330                 335     


Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp 
            340                 345                 350         


Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr 
        355                 360                 365             


Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr 
    370                 375                 380                 


Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe 
385                 390                 395                 400 


Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu 
                405                 410                 415     


Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr 
            420                 425                 430         


Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Gly Ser 
        435                 440                 445             


Lys Ile Arg Ser Val Arg Pro Leu Val Val Leu Leu Val Cys Val Ala 
    450                 455                 460                 


Ala Val Leu Ala Leu Ser Ala Ser Ala Glu Pro His Lys Ala Ala Val 
465                 470                 475                 480 


Asp Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser 
                485                 490                 495     


Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val 
            500                 505                 510         


Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly 
        515                 520                 525             


Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Leu Ser Val Gly Pro 
    530                 535                 540                 


Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu 
545                 550                 555                 560 


Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala 
                565                 570                 575     


Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val 
            580                 585                 590         


Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly 
        595                 600                 605             


Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser 
    610                 615                 620                 


Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu 
625                 630                 635                 640 


Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser 
                645                 650                 655     


Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val 
            660                 665                 670         


Gly Pro Gln Ser Val Asp Val Ser Pro Val Ser Gly Ser Glu Phe Asp 
        675                 680                 685             


Ala Val Asp Trp Arg Glu Lys Gly Ala Val Thr Pro Val Lys Asn Gln 
    690                 695                 700                 


Gly Ala Cys Gly Ser Cys Trp Ala Phe Ser Ala Val Gly Asn Ile Glu 
705                 710                 715                 720 


Ser Gln Trp Ala Arg Ala Gly His Gly Leu Val Ser Leu Ser Glu Gln 
                725                 730                 735     


Gln Leu Val Ser Cys Asp Asp Lys Asp Asn Gly Cys Asn Gly Gly Leu 
            740                 745                 750         


Met Leu Gln Ala Phe Glu Trp Leu Leu Arg His Met Tyr Gly Ile Val 
        755                 760                 765             


Phe Thr Glu Lys Ser Tyr Pro Tyr Thr Ser Gly Asn Gly Asp Val Ala 
    770                 775                 780                 


Glu Cys Leu Asn Ser Ser Lys Leu Val Pro Gly Ala Gln Ile Asp Gly 
785                 790                 795                 800 


Tyr Val Met Ile Pro Ser Asn Glu Thr Val Met Ala Ala Trp Leu Ala 
                805                 810                 815     


Glu Asn Gly Pro Ile Ala Ile Ala Val Asp Ala Ser Ser Phe Met Ser 
            820                 825                 830         


Tyr Gln Ser Gly Val Leu Thr Ser Cys Ala Gly Asp Ala Leu Asn His 
        835                 840                 845             


Gly Val Leu Leu Val Gly Tyr Asn Lys Thr Gly Gly Val Pro Tyr Trp 
    850                 855                 860                 


Val Ile Lys Asn Ser Trp Gly Glu Asp Trp Gly Glu Lys Gly Tyr Val 
865                 870                 875                 880 


Arg Val Val Met Gly Leu Asn Ala Cys Leu Leu Ser Glu Tyr Pro Val 
                885                 890                 895     


Ser Ala His Val Pro Arg Ser Leu Thr Pro Gly Pro Gly Thr Glu Ser 
            900                 905                 910         


Glu Glu Arg Ala Pro Lys Arg Val Thr Val Glu Gln Met Met Cys Thr 
        915                 920                 925             


Asp Met Tyr Cys Arg Glu Gly Cys Lys Lys Ser Leu Leu Thr Ala Asn 
    930                 935                 940                 


Val Cys Tyr Lys Asn Gly Gly Gly Gly Ser Ser Met Thr Lys Cys Gly 
945                 950                 955                 960 


Pro Gln Lys Val Leu Met Cys Ser Tyr Ser Asn Pro His Cys Phe Gly 
                965                 970                 975     


Pro Gly Leu Cys Leu Glu Thr Pro Asp Gly Lys Cys Ala Pro Tyr Phe 
            980                 985                 990         


Leu Gly Ser Ile Met Asn Thr Cys  Gln Tyr Thr 
        995                 1000             


<210>  3
<211>  92
<212>  PRT
<213>  artificial sequence

<220>
<223>  KMP11 protein

<400>  3

Met Ala Thr Thr Tyr Glu Glu Phe Ser Ala Lys Leu Asp Arg Leu Asp 
1               5                   10                  15      


Glu Glu Phe Asn Arg Lys Met Gln Glu Gln Asn Ala Lys Phe Phe Ala 
            20                  25                  30          


Asp Lys Pro Asp Glu Ser Thr Leu Ser Pro Glu Met Lys Glu His Tyr 
        35                  40                  45              


Glu Lys Phe Glu Arg Met Ile Lys Glu His Thr Glu Lys Phe Asn Lys 
    50                  55                  60                  


Lys Met His Glu His Ser Glu His Phe Lys Gln Lys Phe Ala Glu Leu 
65                  70                  75                  80  


Leu Glu Gln Gln Lys Ala Ala Gln Tyr Pro Ser Lys 
                85                  90          


<210>  4
<211>  352
<212>  PRT
<213>  artificial sequence

<220>
<223>  SMT protein

<400>  4

Ser Ala Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg 
1               5                   10                  15      


Asn Lys Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe 
            20                  25                  30          


Arg Asp Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr 
        35                  40                  45              


Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu 
    50                  55                  60                  


Tyr Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu 
65                  70                  75                  80  


Thr Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg 
                85                  90                  95      


Gly Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly Val 
            100                 105                 110         


Gly Gly Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val Ile 
        115                 120                 125             


Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp 
    130                 135                 140                 


Ala Leu Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe 
145                 150                 155                 160 


Cys Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile 
                165                 170                 175     


Glu Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu Val 
            180                 185                 190         


Phe Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys 
        195                 200                 205             


Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys 
    210                 215                 220                 


His Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys Lys 
225                 230                 235                 240 


Gln Val Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu Ala 
                245                 250                 255     


Ile Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro 
            260                 265                 270         


Trp Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg 
        275                 280                 285             


Ser Thr Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val Leu 
    290                 295                 300                 


Glu Phe Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile 
305                 310                 315                 320 


Leu Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile 
                325                 330                 335     


Phe Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala 
            340                 345                 350         


<210>  5
<211>  235
<212>  PRT
<213>  artificial sequence

<220>
<223>  A2 protein

<400>  5

Lys Ile Arg Ser Val Arg Pro Leu Val Val Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Ala Val Leu Ala Leu Ser Ala Ser Ala Glu Pro His Lys Ala Ala Val 
            20                  25                  30          


Asp Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser 
        35                  40                  45              


Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val 
    50                  55                  60                  


Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly 
65                  70                  75                  80  


Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Leu Ser Val Gly Pro 
                85                  90                  95      


Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu 
            100                 105                 110         


Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala 
        115                 120                 125             


Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val 
    130                 135                 140                 


Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly 
145                 150                 155                 160 


Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser 
                165                 170                 175     


Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu 
            180                 185                 190         


Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser 
        195                 200                 205             


Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val 
    210                 215                 220                 


Gly Pro Gln Ser Val Asp Val Ser Pro Val Ser 
225                 230                 235 


<210>  6
<211>  316
<212>  PRT
<213>  artificial sequence

<220>
<223>  CBP protein

<400>  6

Asp Ala Val Asp Trp Arg Glu Lys Gly Ala Val Thr Pro Val Lys Asn 
1               5                   10                  15      


Gln Gly Ala Cys Gly Ser Cys Trp Ala Phe Ser Ala Val Gly Asn Ile 
            20                  25                  30          


Glu Ser Gln Trp Ala Arg Ala Gly His Gly Leu Val Ser Leu Ser Glu 
        35                  40                  45              


Gln Gln Leu Val Ser Cys Asp Asp Lys Asp Asn Gly Cys Asn Gly Gly 
    50                  55                  60                  


Leu Met Leu Gln Ala Phe Glu Trp Leu Leu Arg His Met Tyr Gly Ile 
65                  70                  75                  80  


Val Phe Thr Glu Lys Ser Tyr Pro Tyr Thr Ser Gly Asn Gly Asp Val 
                85                  90                  95      


Ala Glu Cys Leu Asn Ser Ser Lys Leu Val Pro Gly Ala Gln Ile Asp 
            100                 105                 110         


Gly Tyr Val Met Ile Pro Ser Asn Glu Thr Val Met Ala Ala Trp Leu 
        115                 120                 125             


Ala Glu Asn Gly Pro Ile Ala Ile Ala Val Asp Ala Ser Ser Phe Met 
    130                 135                 140                 


Ser Tyr Gln Ser Gly Val Leu Thr Ser Cys Ala Gly Asp Ala Leu Asn 
145                 150                 155                 160 


His Gly Val Leu Leu Val Gly Tyr Asn Lys Thr Gly Gly Val Pro Tyr 
                165                 170                 175     


Trp Val Ile Lys Asn Ser Trp Gly Glu Asp Trp Gly Glu Lys Gly Tyr 
            180                 185                 190         


Val Arg Val Val Met Gly Leu Asn Ala Cys Leu Leu Ser Glu Tyr Pro 
        195                 200                 205             


Val Ser Ala His Val Pro Arg Ser Leu Thr Pro Gly Pro Gly Thr Glu 
    210                 215                 220                 


Ser Glu Glu Arg Ala Pro Lys Arg Val Thr Val Glu Gln Met Met Cys 
225                 230                 235                 240 


Thr Asp Met Tyr Cys Arg Glu Gly Cys Lys Lys Ser Leu Leu Thr Ala 
                245                 250                 255     


Asn Val Cys Tyr Lys Asn Gly Gly Gly Gly Ser Ser Met Thr Lys Cys 
            260                 265                 270         


Gly Pro Gln Lys Val Leu Met Cys Ser Tyr Ser Asn Pro His Cys Phe 
        275                 280                 285             


Gly Pro Gly Leu Cys Leu Glu Thr Pro Asp Gly Lys Cys Ala Pro Tyr 
    290                 295                 300                 


Phe Leu Gly Ser Ile Met Asn Thr Cys Gln Tyr Thr 
305                 310                 315     


