                         SEQUENCE LISTING

<110>  Qvit, Nir
       Mochly-Rosen, Daria
       Schechtman , Deborah
       Churchill, Eric
 
<120>  COMPOSITIONS AND METHODS FOR SPECIFIC INHIBITION OF LEISHMANIA 
       RECEPTOR FOR ACTIVATED C-KINASE (LACK)

<130>  091511-0563

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  1

Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly Tyr 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  2

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  3

Cys Val Ser Leu Ala His Ala Thr Asp 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  4

Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly Tyr 
1               5                   10      


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  5

Arg Asn Gly Gln Cys Gln Arg Lys 
1               5               


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  6

Met His Glu Phe Leu Arg Asp 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  7

Asn Val Ile Arg Val Trp Asn 
1               5           


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  8

Val Asn Gly Gly Lys Cys Glu Arg Thr Leu Lys 
1               5                   10      


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  9

Ser Thr Gly Glu Gln Leu Phe Lys Ile Asn Val Glu Ser Pro 
1               5                   10                  


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  10

Thr Pro Asp Gly Ala Lys Pro Ser Glu 
1               5                   


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  11

Arg Ser Leu Ser Val Tyr Asp 
1               5           


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  12

Gln Lys Lys Gly Asp Ile Thr Asp Pro Tyr Val Lys Leu 
1               5                   10              


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  13

Lys Thr Ser Val Val Arg Asn Asn 
1               5               


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  14

Gly Leu Asn Pro Tyr Trp Met Glu Thr 
1               5                   


<210>  15
<211>  149
<212>  PRT
<213>  Trypanosoma brucei

<400>  15

Met Ala Asp Gln Leu Ser Asn Glu Gln Ile Ser Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Gln Asp Gly Ser Gly Thr Ile 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Thr Leu Met Ala Arg Lys Met Gln Asp Ser 
65                  70                  75                  80  


Asp Ser Glu Glu Glu Ile Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Phe Asn Ser Ala Ala Glu Leu Arg His Ile Met Thr Asn 
            100                 105                 110         


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             


Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 
    130                 135                 140                 


Met Met Met Ser Lys 
145                 


<210>  16
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe 
1               5                   10                  15      


Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu 
            20                  25                  30          


Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu 
        35                  40                  45              


Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr Ile Asp 
    50                  55                  60                  


Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp 
65                  70                  75                  80  


Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly 
                85                  90                  95      


Asp Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu 
            100                 105                 110         


Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala 
        115                 120                 125             


Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Thr Met 
    130                 135                 140                 


Met Thr Ser Lys 
145             


<210>  17
<211>  652
<212>  PRT
<213>  Trypanosoma cruzi

<400>  17

Met Leu Leu Gln Ala Leu Leu Val Leu Ser Ala Val Val Val Ala Val 
1               5                   10                  15      


Ala Ala Pro Asp Gly Thr Gly Lys Val Glu Ala Pro Cys Val Gly Ile 
            20                  25                  30          


Asp Leu Gly Thr Thr Tyr Ser Val Val Gly Val Trp Gln Lys Gly Asp 
        35                  40                  45              


Val His Ile Ile Pro Asn Asp Met Gly Asn Arg Ile Thr Pro Ser Val 
    50                  55                  60                  


Val Ala Phe Thr Glu Thr Glu Arg Leu Ile Gly Asp Gly Ala Lys Asn 
65                  70                  75                  80  


Gln Leu Pro Gln Asn Pro His Asn Thr Ile Tyr Ala Ile Lys Arg Leu 
                85                  90                  95      


Ile Gly Arg Lys Tyr Ser Asp Thr Thr Val Gln Thr Asp Lys Lys Leu 
            100                 105                 110         


Leu Ser Tyr Glu Val Val Ala Asp Lys Asp Gly Lys Pro Lys Val Glu 
        115                 120                 125             


Val Glu Val Gly Gly Lys Lys Lys Gln Phe Thr Pro Glu Glu Val Ser 
    130                 135                 140                 


Ala Met Val Leu Gln Lys Met Lys Glu Ile Ala Glu Thr Tyr Leu Gly 
145                 150                 155                 160 


Glu Lys Val Lys Asn Ala Val Val Thr Val Pro Ala Tyr Phe Asn Glu 
                165                 170                 175     


Pro Gln Arg Gln Ser Thr Lys Asp Ala Gly Thr Ile Ala Gly Leu Asn 
            180                 185                 190         


Val Val Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly 
        195                 200                 205             


Leu Asn Lys Ala Gly Glu Lys Asn Ile Leu Val Phe Asp Leu Gly Gly 
    210                 215                 220                 


Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Glu Gly Phe Phe Glu 
225                 230                 235                 240 


Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp 
                245                 250                 255     


Asn Asn Met Met Arg Tyr Phe Val Asp Met Leu Lys Lys Lys Lys Asn 
            260                 265                 270         


Val Asp Val Ser Lys Asp Gln Lys Ala Leu Ala Arg Leu Arg Cys Glu 
        275                 280                 285             


Ala Cys Glu Ala Ala Lys Arg Gln Leu Ser Ser His Pro Glu Ala Arg 
    290                 295                 300                 


Val Glu Val Asp Ser Leu Thr Glu Gly Phe Asp Phe Ser Glu Lys Ile 
305                 310                 315                 320 


Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Glu Leu Phe Lys Gly Thr 
                325                 330                 335     


Leu Val Pro Val Gln Arg Val Leu Glu Asp Ala Lys Leu Lys Lys Ser 
            340                 345                 350         


Asp Ile His Glu Ile Val Leu Val Gly Gly Ser Thr Arg Val Pro Lys 
        355                 360                 365             


Val Gln Gln Leu Ile Arg Asp Phe Phe Gly Gly Lys Glu Pro Asn Arg 
    370                 375                 380                 


Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala 
385                 390                 395                 400 


Ala Val Leu Thr Gly Glu Ser Glu Val Gly Gly Arg Val Val Leu Val 
                405                 410                 415     


Asp Val Ile Pro Leu Ser Leu Gly Ile Glu Thr Val Gly Gly Val Met 
            420                 425                 430         


Thr Lys Leu Ile Glu Arg Asn Thr Gln Ile Pro Thr Lys Lys Ser Gln 
        435                 440                 445             


Val Phe Ser Thr Tyr Gln Asp Asn Gln Pro Gly Val Leu Ile Gln Val 
    450                 455                 460                 


Tyr Glu Gly Glu Arg Gln Met Thr Lys Asp Asn Arg Leu Leu Gly Lys 
465                 470                 475                 480 


Phe Glu Leu Ser Gly Ile Pro Pro Arg Pro Arg Ala Val Pro Gln Ile 
                485                 490                 495     


Glu Val Thr Phe Asp Val Asp Glu Asn Ser Ile Leu Gln Val Ser Ala 
            500                 505                 510         


Val Asp Lys Ser Ser Gly Lys Lys Glu Glu Ile Thr Ile Thr Asn Asp 
        515                 520                 525             


Lys Gly Arg Leu Ser Glu Glu Glu Ile Glu Arg Met Val Arg Glu Ala 
    530                 535                 540                 


Ala Glu Phe Glu Gly Glu Asp Arg Lys Val Arg Glu Arg Val Asp Ala 
545                 550                 555                 560 


Arg Asn Ser Leu Glu Ser Val Ala Tyr Ser Leu Arg Asn Gln Val Asn 
                565                 570                 575     


Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ala Asp Asp Lys Ser Ala 
            580                 585                 590         


Val Glu Ala Ala Val Lys Glu Ala Met Gln Phe Leu Asp Asp Asn Pro 
        595                 600                 605             


Asn Ala Asp Lys Glu Glu Tyr Asp Glu Ala Arg Asp Lys Leu Gln Ser 
    610                 615                 620                 


Val Thr Asn Pro Ile Ile Gln Lys Val Tyr Gln Ser Gly Gly Gly Ala 
625                 630                 635                 640 


Asp Gly Asp Glu Arg Pro Glu Pro Met Asp Asp Leu 
                645                 650         


<210>  18
<211>  395
<212>  PRT
<213>  Trypanosoma cruzi

<400>  18

Ser Thr Ala Thr Gly His Leu Ile Tyr Lys Cys Gly Gly Ile Asp Lys 
1               5                   10                  15      


Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu Ile Gly Lys Ser 
            20                  25                  30          


Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys Ala Glu Arg Glu 
        35                  40                  45              


Arg Gly Ile Thr Ile Asp Ile Ala Leu Trp Lys Phe Glu Ser Pro Lys 
    50                  55                  60                  


Ser Val Phe Thr Ile Ile Asp Ala Pro Gly His Arg Asp Phe Ile Lys 
65                  70                  75                  80  


Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Ala Ala Val Leu Val Ile 
                85                  90                  95      


Ala Ser Ser Gln Gly Glu Phe Glu Ala Gly Ile Ser Lys Asp Gly Gln 
            100                 105                 110         


Thr Arg Glu His Ala Leu Leu Ala Phe Thr Leu Gly Val Lys Gln Met 
        115                 120                 125             


Val Val Cys Cys Asn Lys Met Asp Asp Lys Ser Val Asn Phe Ala Gln 
    130                 135                 140                 


Glu Arg Tyr Asp Glu Ile Val Lys Glu Val Ser Ala Tyr Leu Lys Lys 
145                 150                 155                 160 


Val Gly Tyr Asn Val Glu Lys Val Arg Phe Ile Pro Ile Ser Gly Trp 
                165                 170                 175     


Gln Gly Asp Asn Met Ile Asp Lys Ser Glu Asn Met Pro Trp Tyr Lys 
            180                 185                 190         


Gly Pro Thr Leu Leu Glu Ala Leu Asp Met Leu Glu Pro Pro Val Arg 
        195                 200                 205             


Pro Ser Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
    210                 215                 220                 


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Thr Met 
225                 230                 235                 240 


Lys Pro Gly Asp Val Val Thr Phe Ala Pro Ala Asn Val Thr Thr Glu 
                245                 250                 255     


Val Lys Ser Ile Glu Met His His Glu Gln Leu Ala Glu Ala Thr Pro 
            260                 265                 270         


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Ile 
        275                 280                 285             


Arg Arg Gly Asn Val Cys Gly Asn Ser Lys Asn Asp Pro Pro Lys Glu 
    290                 295                 300                 


Ala Ala Asp Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
305                 310                 315                 320 


Ile Gly Asn Gly Tyr Ala Pro Val Leu Asp Cys His Thr Cys His Ile 
                325                 330                 335     


Ala Cys Lys Phe Ala Glu Ile Glu Ser Lys Ile Asp Arg Arg Ser Gly 
            340                 345                 350         


Lys Glu Leu Glu Lys Asn Pro Lys Ser Ile Lys Ser Gly Asp Ala Ala 
        355                 360                 365             


Met Val Arg Met Val Pro Gln Lys Pro Met Cys Val Glu Val Phe Asn 
    370                 375                 380                 


Asp Tyr Ala Pro Leu Gly Arg Phe Ala Val Arg 
385                 390                 395 


<210>  19
<211>  678
<212>  PRT
<213>  Trypanosoma cruzi

<400>  19

Met Thr Tyr Glu Gly Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Trp Gln Asn Glu Arg Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Ser Pro Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Ser Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Lys Val Ile Thr 
                85                  90                  95      


Lys Gly Asp Asp Lys Pro Val Ile Gln Val Gln Phe Arg Gly Glu Thr 
            100                 105                 110         


Lys Thr Phe Asn Pro Glu Glu Val Ser Ser Met Val Leu Ser Lys Met 
        115                 120                 125             


Lys Glu Ile Ala Glu Ser Tyr Leu Gly Lys Gln Val Lys Lys Ala Val 
    130                 135                 140                 


Val Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys 
145                 150                 155                 160 


Asp Ala Gly Thr Ile Ala Gly Met Glu Val Leu Arg Ile Ile Asn Glu 
                165                 170                 175     


Pro Thr Arg Ala Ala Ile Ala Tyr Gly Leu Asp Lys Val Glu Asp Gly 
            180                 185                 190         


Lys Glu Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp 
        195                 200                 205             


Val Thr Leu Leu Thr Ile Asp Gly Gly Ile Phe Glu Val Lys Ala Thr 
    210                 215                 220                 


Asn Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val 
225                 230                 235                 240 


Ser His Phe Thr Asp Glu Phe Lys Arg Lys Asn Lys Gly Lys Asp Leu 
                245                 250                 255     


Thr Thr Ser Gln Arg Ala Leu Arg Arg Leu Arg Thr Ala Cys Glu Arg 
            260                 265                 270         


Ala Lys Arg Thr Leu Ser Ser Ala Ala Gln Ala Thr Ile Glu Ile Asp 
        275                 280                 285             


Ala Leu Phe Asp Asn Val Asp Phe Gln Ala Thr Ile Thr Arg Ala Arg 
    290                 295                 300                 


Phe Glu Glu Leu Cys Gly Asp Leu Phe Arg Gly Thr Leu Gln Pro Val 
305                 310                 315                 320 


Glu Arg Val Leu Gln Asp Ala Lys Met Asp Lys Arg Ala Val His Asp 
                325                 330                 335     


Val Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Val Met Gln Leu 
            340                 345                 350         


Val Ser Asp Phe Phe Gly Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro 
        355                 360                 365             


Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Phe Ile Leu Thr 
    370                 375                 380                 


Gly Gly Lys Ser Lys Gln Thr Glu Gly Leu Leu Leu Leu Asp Val Thr 
385                 390                 395                 400 


Pro Leu Thr Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Ser Leu 
                405                 410                 415     


Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Lys Ser Gln Ile Phe Ser 
            420                 425                 430         


Thr Tyr Ala Asp Asn Gln Pro Gly Val His Ile Gln Val Phe Glu Gly 
        435                 440                 445             


Glu Arg Ala Met Thr Lys Asp Cys His Leu Leu Gly Thr Phe Asp Leu 
    450                 455                 460                 


Ser Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr 
465                 470                 475                 480 


Phe Asp Leu Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Glu Glu Lys 
                485                 490                 495     


Gly Thr Gly Lys Arg Asn Gln Ile Val Ile Thr Asn Asp Lys Gly Arg 
            500                 505                 510         


Leu Ser Lys Ala Asp Ile Glu Arg Met Val Ser Glu Ala Ala Lys Tyr 
        515                 520                 525             


Glu Ser Gln Asp Lys Glu Gln Arg Glu Arg Ile Asp Ala Lys Asn Gly 
    530                 535                 540                 


Leu Glu Asn Tyr Ala Phe Ser Met Lys Asn Thr Val Asn Glu Pro Asn 
545                 550                 555                 560 


Val Ala Gly Lys Ile Glu Glu Ala Asp Lys Asn Thr Ile Thr Ser Ala 
                565                 570                 575     


Val Glu Glu Ala Leu Gln Trp Leu Asn Asn Asn Gln Glu Ala Ser Lys 
            580                 585                 590         


Glu Glu Tyr Glu His Arg Gln Lys Glu Leu Glu Asn Leu Cys Thr Pro 
        595                 600                 605             


Ile Met Thr Lys Met Tyr Gln Gly Met Gly Ala Gly Gly Gly Met Pro 
    610                 615                 620                 


Gly Gly Met Pro Gly Gly Met Pro Gly Gly Met Pro Gly Gly Ala Asn 
625                 630                 635                 640 


Pro Ser Ser Ser Ser Gly Pro Lys Val Glu Glu Val Glu Arg Gly Arg 
                645                 650                 655     


Ile Pro Glu Asp Val Leu Met Ala Ala Ser Ala Arg Glu Arg Ile Thr 
            660                 665                 670         


Arg Trp Phe Ser Pro Leu 
        675             


<210>  20
<211>  651
<212>  PRT
<213>  Trypanosoma cruzi

<400>  20

Met Leu Leu Gln Ala Leu Leu Val Leu Ser Ala Val Val Val Ala Val 
1               5                   10                  15      


Ala Ala Pro Asp Gly Thr Gly Lys Val Glu Ala Pro Cys Val Gly Ile 
            20                  25                  30          


Asp Leu Gly Thr Thr Tyr Ser Val Val Gly Val Trp Gln Lys Gly Asp 
        35                  40                  45              


Val His Ile Ile Pro Asn Asp Met Gly Asn Arg Ile Thr Pro Ser Val 
    50                  55                  60                  


Val Ala Phe Thr Glu Thr Glu Arg Leu Ile Gly Asp Gly Ala Lys Asn 
65                  70                  75                  80  


Gln Leu Pro Gln Asn Pro His Asn Thr Ile Tyr Ala Ile Lys Arg Leu 
                85                  90                  95      


Ile Gly Arg Lys Tyr Ser Asp Ala Thr Val Gln Thr Asp Lys Lys Leu 
            100                 105                 110         


Leu Ser Tyr Glu Val Val Ala Asp Lys Asp Gly Lys Pro Lys Val Gln 
        115                 120                 125             


Val Glu Val Gly Gly Lys Lys Lys Gln Phe Thr Pro Glu Glu Val Ser 
    130                 135                 140                 


Ala Met Val Leu Gln Lys Met Lys Glu Ile Ala Glu Thr Tyr Leu Gly 
145                 150                 155                 160 


Glu Lys Val Lys Asn Ala Val Val Thr Val Pro Ala Tyr Phe Asn Asp 
                165                 170                 175     


Ala Gln Arg Gln Ser Thr Lys Asp Ala Gly Thr Ile Ala Gly Leu Asn 
            180                 185                 190         


Val Val Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly 
        195                 200                 205             


Leu Asn Lys Ala Gly Glu Lys Asn Ile Leu Val Phe Asp Leu Gly Gly 
    210                 215                 220                 


Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Glu Gly Phe Phe Glu 
225                 230                 235                 240 


Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp 
                245                 250                 255     


Asn Asn Met Met Arg Tyr Phe Val Asp Met Leu Lys Lys Lys Lys Asn 
            260                 265                 270         


Val Asp Val Ser Lys Asp Gln Lys Ala Leu Ala Arg Leu Arg Lys Ala 
        275                 280                 285             


Cys Glu Ala Ala Lys Arg Gln Leu Ser Ser His Pro Glu Ala Arg Val 
    290                 295                 300                 


Glu Val Asp Ser Leu Thr Glu Gly Phe Asp Phe Ser Glu Lys Ile Thr 
305                 310                 315                 320 


Arg Ala Lys Phe Glu Glu Leu Asn Met Glu Leu Phe Lys Gly Thr Leu 
                325                 330                 335     


Val Pro Val Gln Arg Val Leu Glu Asp Ala Lys Leu Lys Lys Ser Asp 
            340                 345                 350         


Ile His Glu Ile Val Leu Val Gly Gly Ser Thr Arg Val Pro Lys Val 
        355                 360                 365             


Gln Gln Leu Ile Arg Asp Phe Phe Gly Gly Lys Glu Pro Asn Arg Gly 
    370                 375                 380                 


Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala 
385                 390                 395                 400 


Val Leu Thr Gly Glu Ser Glu Val Gly Gly Arg Val Val Leu Val Asp 
                405                 410                 415     


Val Ile Pro Leu Ser Leu Gly Ile Glu Thr Val Gly Gly Val Met Thr 
            420                 425                 430         


Lys Leu Ile Glu Arg Asn Thr Gln Ile Pro Thr Lys Lys Ser Gln Val 
        435                 440                 445             


Phe Ser Thr Tyr Gln Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr 
    450                 455                 460                 


Glu Gly Glu Arg Gln Met Thr Lys Asp Asn Arg Leu Leu Gly Lys Phe 
465                 470                 475                 480 


Glu Leu Ser Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu 
                485                 490                 495     


Val Thr Phe Asp Val Asp Glu Asn Ser Ile Leu Gln Val Ser Ala Val 
            500                 505                 510         


Asp Lys Ser Ser Gly Lys Lys Glu Glu Ile Thr Ile Thr Asn Asp Lys 
        515                 520                 525             


Gly Arg Leu Ser Glu Glu Glu Ile Glu Arg Met Val Arg Glu Ala Ala 
    530                 535                 540                 


Glu Phe Glu Asp Glu Asp Arg Lys Val Arg Glu Arg Val Asp Ala Arg 
545                 550                 555                 560 


Asn Ser Leu Glu Ser Val Ala Tyr Ser Leu Arg Asn Gln Val Asn Asp 
                565                 570                 575     


Lys Glu Lys Leu Gly Gly Lys Leu Ser Ala Asp Asp Lys Ser Ala Val 
            580                 585                 590         


Glu Ala Ala Val Lys Glu Ala Met Gln Phe Leu Asp Asp Asn Pro Asn 
        595                 600                 605             


Ala Asp Lys Glu Glu Tyr Asp Glu Ala Arg Asp Lys Leu Gln Ser Val 
    610                 615                 620                 


Thr Asn Pro Ile Ile Gln Lys Val Tyr Gln Ser Gly Gly Gly Ala Asp 
625                 630                 635                 640 


Gly Asp Glu Arg Pro Glu Pro Met Asp Asp Leu 
                645                 650     


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  21

Gln Gln Ala Gly Ser Tyr Ile Lys Val Val 
1               5                   10  


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  22

Arg His Ser Val Asp Ser Asp Tyr Gly Leu Pro Ser His 
1               5                   10              


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  23

Glu Gly His Leu Lys Gly His Arg Gly Trp 
1               5                   10  


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  24

Asp Gly Thr Ala Ile Ser 
1               5       


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  25

Ala Asn Pro Asp Arg His Ser Val Ser 
1               5                   


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  26

Gly Leu Pro Ser His Arg Leu Glu 
1               5               


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  27

Thr Gly Phe Val Ser Cys 
1               5       


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  28

Arg Ser Ile Arg Met Trp Asp 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  29

Cys Gln Arg Lys Phe Leu Lys 
1               5           


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  30

Trp Val Ser Ser Ile Cys Phe Ser Pro Ser Leu Glu His 
1               5                   10              


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  31

Asn Val Glu Ser Pro Ile Asn Gln Ile Ala 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  32

Lys Pro Ser Glu Cys Ile Ser Ile Ala Trp 
1               5                   10  


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  33

Gly His Lys Asp Asn Leu 
1               5       


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  34

Asp Val Val Ile Asn Ser Asp Gly Gln 
1               5                   


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  35

Asn Ala Gly Val Thr Val Arg Ser 
1               5               


